bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of earthquake sequences on risk‐based catastrophe bond pricing
Authors: Mistry Harsh K. , Hernandez Andres , Guéguen Philippe , Lombardi Domenico 
Published: March 2024

AbstractCatastrophe bonds (cat bond in short) are an alternative risk‐transfer instrument used to transfer peril‐specific financial risk from governments, financial institutions, or (re)insurers, to the capital market. Current approaches for cat bond pricing are calibrated on seismic mainshocks, and thus do not account for potential effects induced by earthquake sequences. This simplifying assumption implies that damage arises from mainshocks only, while aftershocks yield no damage. Postearthquake field surveys reveal that this assumption is inaccurate. For example, in the 2011 Christchurch Earthquake sequence and 2016–2017 Central Italy Earthquake sequence, aftershocks were responsible for higher economic losses when compared to those caused by mainshocks. This article proposes a time‐dependent aggregate loss model that takes into account seismicity clustering and damage accumulation effects in the computation of damage. The model is calibrated on the seismic events recorded during the recent 2016–2017 Central Italy Earthquake sequence. Furthermore, the effects of earthquake sequence on cat bond pricing is explored by implementing the proposed model on five Italian municipalities. The investigation showed that neglecting time‐dependency may lead to higher difference (up to 45%) in the cat bond price when compared to standard approaches.
Kirillov structures and reduction of Hamiltonian systems by scaling and standard symmetries
Authors: Bravetti A. , Grillo S. , Marrero J. C. , Padrón E. 
Published: March 2024

AbstractIn this paper, we discuss the reduction of symplectic Hamiltonian systems by scaling and standard symmetries which commute. We prove that such a reduction process produces a so‐called Kirillov Hamiltonian system. Moreover, we show that if we reduce first by the scaling symmetries and then by the standard ones or in the opposite order, we obtain equivalent Kirillov Hamiltonian systems. In the particular case when the configuration space of the symplectic Hamiltonian system is a Lie group , which coincides with the symmetry group, the reduced structure is an interesting Kirillov version of the Lie–Poisson structure on the dual space of the Lie algebra of . We also discuss a reconstruction process for symplectic Hamiltonian systems which admit a scaling symmetry. All the previous results are illustrated in detail with some interesting examples.
Barriers and mediators for routine dental care visits from the experiences of immigrant parents of autistic children living in the United States
Authors: Imanpour Sara , Ullah Rukhsar 
Published: March 2024

AbstractIntroductionImmigrants are reluctant to attend routine dental care visits. Moreover, children with autism have a higher chance of developing periodontal disease. In this study, we describe the experiences of immigrant parents with autistic children and the barriers and mediators to routine dental care visits for their children in the United States.MethodWe conducted semistructured interviews with 19 immigrants who have children with autism.ResultsWe found that lack of transportation, support system, and insurance; prioritization of basic needs; and a mistrust of healthcare providers are the main barriers to attending routine dental care visits for autistic children of immigrant parents. Moreover, staff who consider the needs of children with autism, spend ample time with children with autism, and help with navigating the health system can improve access to routine dental care visits for autistic children with immigrant parents. This study found that despite their immigration status, all parents want to see improvements in the oral health of their children with special needs.ConclusionThis study aimed to unpack the structural barriers and mediators to routine dental care visits for autistic children of immigrant parents. We found that removing structural barriers to care and utilizing mediators will enhance the outcome of routine dental care, resulting in healthier oral hygiene.
From isotopically labeled DNA to fluorescently labeled dynamic pili: building a mechanistic model of DNA transport to the cytoplasmic membrane
Authors: Zuke Jason D. , Burton Briana M. 
Published: March 2024

SUMMARY
Natural competence, the physiological state wherein bacteria produce proteins that mediate extracellular DNA transport into the cytosol and the subsequent recombination of DNA into the genome, is conserved across the bacterial domain. DNA must successfully translocate across formidable permeability barriers during import, including the cell membrane(s) and the cell wall, that are normally impermeable to large DNA polymers. This review will examine the mechanisms underlying DNA transport from the extracellular space to the cytoplasmic membrane. First, the challenges inherent to DNA movement through the cell periphery will be discussed to provide context for DNA transport during natural competence. The following sections will trace the development of a comprehensive model for DNA translocation to the cytoplasmic membrane, highlighting the crucial studies performed over the last century that have contributed to building contemporary DNA import models. Finally, this review will conclude by reflecting on what is still unknown about the process and the possible solutions to overcome these limitations.
Whole-genome sequencing of
Aminobacterium
sp. strain MB27-C1, isolated from the wastewater treatment plant of a steel mill
Authors: Huang Junlin , Wu Chih-Hung , Shih Chao-Jen , Wu Yen-Chi , Lai Shu-Jung , You Yi-Ting , Chen Sheng-Chung 
Published: March 2024

ABSTRACT

Here, we report the complete genome sequence of
Aminobacterium
sp. strain MB27-C1, which was isolated from sewage sludge collected at the wastewater treatment plant of Sanming Steel Co. Ltd. in Fujian, China. The resulting genome of strain MB27-C1 is a single contig of 2,427,830 bp with 41.58% GC content.
Metagenomic sequencing reveals viral diversity of mosquitoes from Shandong Province, China
Authors: Wang Yuhao , Lin Xiaojuan , Li Chao , Liu Guifang , Wang Suting , Chen Meng , Wei Xuemin , Wen Hongling , Tao Zexin , Xu Yifei 
Published: March 2024

ABSTRACT

Mosquitoes carry a large number of known and unknown viruses, some of which could cause serious diseases in humans or animals. Metagenomic sequencing for mosquito viromes is crucial for understanding the evolutionary history of viruses and preventing emerging mosquito-borne diseases. We collected 1,598 mosquitoes belonging to four species from five counties in Shandong Province, China in 2021. They were grouped by species and sampling locations and subjected to metagenomic next-generation sequencing for the analysis of the viromes. A total of 233,317,352 sequencing reads were classified into 30 viral families and an unclassified group. Comparative analysis showed that mosquitoes in Shandong Province generally possessed host-specific virome. We detected mosquito-borne viruses including Japanese encephalitis virus, Getah virus, and Kadipiro virus in
Culex tritaeniorhynchus
and
Anopheles sinensis
samples. Phylogenetic analysis showed that these pathogenic viruses may have existed in mosquitoes in Shandong Province for a long time. Meanwhile, we identified 22 novel viruses belonging to seven families and the genus
Negevirus
. Our study comprehensively described the viromes of several common mosquito species in Shandong Province, China, and demonstrated the major role of host species in shaping mosquito viromes. Furthermore, the metagenomic data provided valuable epidemiological information on multiple mosquito-borne viruses, highlighting the potential risk of infection transmission.

IMPORTANCE

Mosquitoes are known as the source of various pathogens for humans and animals.
Culex tritaeniorhynchus
,
Armigeres subalbatus
, and
Anopheles sinensis
have been found to transmit the Getah virus, which has recently caused increasing infections in China.
Cx. tritaeniorhynchus
and
Culex pipiens
are the main vectors of Japanese encephalitis virus and have caused epidemics of Japanese encephalitis in China in past decades. These mosquitoes are widely present in Shandong Province, China, leading to a great threat to public health and the breeding industry. This study provided a comprehensive insight into the viromes of several common mosquito species in Shandong Province, China. The metagenomic sequencing data revealed the risks of multiple pathogenic mosquito-borne viruses, including Japanese encephalitis virus, Getah virus, and Kadipiro virus, which are of great importance for preventing emerging viral epidemics.
Probing atmospheric effects using GRAPES-3 plastic scintillator detectors
Authors:   GRAPES-3 Collaboration, Zuberi M. , Ahmad S. , Chakraborty M. , Chandra A. , Dugad S. R. , Goswami U. D. , Gupta S. K. , Hariharan B. , Hayashi Y. , Jagadeesan P. , Jain A. , Jain P. , Jhansi V. B. , Kawakami S. , Kojima H. , Mahapatra S. , Mohanty P. K. , Muraki Y. , Nayak P. K. , Nonaka T. , Oshima A. , Pattanaik D. , Rameez M. , Ramesh K. , Reddy L. V. , Shibata S. , Varsi F. 
Published: March 2024

AbstractThe GRAPES-3 extensive air shower (EAS) array has been designed to study cosmic rays from 10$$^{13}$$

13

–10$$^{16}$$

16

eV. It employs 400 scintillator detectors spread across 25,000 m$$^{2}$$

2

, mainly of cone-type and fiber-type, each covering a 1 m$$^{2}$$

2

area. These detectors record EAS particle densities and arrival times, which are crucial for determining primary particle energy and direction. A decade (2013–2022) of EAS data is analyzed to investigate the dependence of particle densities on ambient temperature and atmospheric pressure. Notably, ambient temperature exhibits a delayed response, with a more pronounced delay in fiber-type detectors, while cone-type detectors exhibit a higher observed temperature coefficient. In contrast, atmospheric pressure instantly and uniformly affects both detector types, with Monte Carlo simulations backing the observed pressure coefficient. These findings established a reliable pressure coefficient for EAS within this distinctive energy range and contributed to the refinement of correction algorithms, ultimately improving particle density precision for more accurate shower parameter estimates.
Quark stars in $$D_3$$–$$D_7$$ holographic model
Authors: Aleixo M. , Lenzi C. H. , de Paula W. , Rocha R. da 
Published: March 2024

AbstractThis work investigates static and dynamical quark star properties within a $$D_3{-}D_7$$

D
3

-

D
7

holographic model. We solve the Tolman–Oppenheimer–Volkoff equations for the quark matter equation of state obtained from the brane configuration. We determine the mass-radius diagram for a range of model parameters and compare with recent NICER observational data for the pulsars PSR J$$0030+0451$$

0030
+
0451

and PSR J$$0740+6620.$$

0740
+
6620
.

Motivated by the GW170817 event detected by the LIGO-Virgo collaboration, we also calculate the tidal deformability parameter obtained for each component of the binary star system. We show that quark stars composed of flavor-independent quark matter derived from the $$D_3{-}D_7$$

D
3

-

D
7

holographic model are not able to satisfy simultaneously the LIGO-Virgo and NICER astrophysical bounds.
Gravity-induced entanglement between two massive microscopic particles in curved spacetime: I. The Schwarzschild background
Authors: Zhang Chi , Shu Fu-Wen 
Published: March 2024

AbstractThe experiment involving the entanglement of two massive particles through gravitational fields has been devised to discern the quantum attributes of gravity. In this paper, we present a scheme to extend this experiment’s applicability to more generalized curved spacetimes, with the objective of validating universal quantum gravity within broader contexts. Specifically, we direct our attention towards the quantum gravity induced entanglement of masses (QGEM) in astrophysical phenomena, such as particles traversing the interstellar medium. Notably, we ascertain that the gravitational field within curved spacetime can induce observable entanglement between particle pairs in both scenarios, even when dealing with particles significantly smaller than mesoscopic masses. Furthermore, we obtain the characteristic spectra of QGEM across diverse scenarios, shedding light on potential future experimental examinations. This approach not only establishes a more pronounced and extensive manifestation of the quantum influences of gravity compared to the original scheme but also opens avenues for prospective astronomical experiments. These experiments, aligned with our postulates, hold immense advantages and implications for the detection of quantum gravity and can be envisioned for future design.
Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma
Authors: Oliver-Caldes Aina , Español-Rego Marta , Zabaleta Aintzane , González-Calle Verónica , Navarro-Velázquez Sergio , Inogés Susana , de Cerio Ascensión López-Díaz , Cabañas Valentín , López-Muñoz Nieves , Rodríguez-Otero Paula , Reguera Juan Luis , Moreno David F. , Martínez-Cibrian Nuria , López-Corral Lucía , Pérez-Amill Lorena , Martin-Antonio Beatriz , Rosiñol Laura , Cid Joan , Tovar Natalia , Sáez-Peñataro Joaquín , López-Parra Miriam , Olesti Eulalia , Guillén Elena , Varea Sara , Rodríguez-Lobato Luis Gerardo , Battram Anthony M. , González Marta Sonia , Sánchez-Salinas Andrés , González-Navarro Azucena , Ortiz-Maldonado Valentín , Delgado Julio , Prósper Felipe , Juan Manel , Martínez-López Joaquín , Moraleda José M. , Mateos Maria Victoria , Urbano-Ispizua Álvaro , Paiva Bruno , Pascal Mariona , Fernández de Larrea Carlos 
Published: March 2024

Abstract

Purpose:
B-cell maturation antigen (BCMA)-chimeric antigen receptor T-cells (CART) improve results obtained with conventional therapy in the treatment of relapsed/refractory multiple myeloma. However, the high demand and expensive costs associated with CART therapy might prove unsustainable for health systems. Academic CARTs could potentially overcome these issues. Moreover, response biomarkers and resistance mechanisms need to be identified and addressed to improve efficacy and patient selection. Here, we present clinical and ancillary results of the 60 patients treated with the academic BCMA-CART, ARI0002h, in the CARTBCMA-HCB-01 trial.

Patients and Methods:
We collected apheresis, final product, peripheral blood and bone marrow samples before and after infusion. We assessed BCMA, T-cell subsets, CART kinetics and antibodies, B-cell aplasia, cytokines, and measurable residual disease by next-generation flow cytometry, and correlated these to clinical outcomes.

Results:
At cut-off date March 17, 2023, with a median follow-up of 23.1 months (95% CI, 9.2–37.1), overall response rate in the first 3 months was 95% [95% confidence interval (CI), 89.5–100]; cytokine release syndrome (CRS) was observed in 90% of patients (5% grades ≥3) and grade 1 immune effector cell-associated neurotoxicity syndrome was reported in 2 patients (3%). Median progression-free survival was 15.8 months (95% CI, 11.5–22.4). Surface BCMA was not predictive of response or survival, but soluble BCMA correlated with worse clinical outcomes and CRS severity. Activation marker HLA-DR in the apheresis was associated with longer progression-free survival and increased exhaustion markers correlated with poorer outcomes. ARI0002h kinetics and loss of B-cell aplasia were not predictive of relapse.

Conclusions:
Despite deep and sustained responses achieved with ARI0002h, we identified several biomarkers that correlate with poor outcomes.
Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells
Authors: Baba Tomohisa , Tomaru Utano , Hirao Atsushi , Mukaida Naofumi , Johmura Yoshikazu 
Published: March 2024

Abstract

Accumulating evidence indicates that various oncogenic mutations interfere with normal myeloid differentiation of leukemogenic cells during the early process of acute myeloid leukemia (AML) development. Differentiation therapy is a therapeutic strategy capable of terminating leukemic expansion by reactivating the differentiation potential; however, the plasticity and instability of leukemia cells counteract the establishment of treatments aimed at irreversibly inducing and maintaining their differentiation states. On the basis of our previous observation that autophagy inhibitor treatment induces the accumulation of cytosolic DNA and activation of cytosolic DNA-sensor signaling selectively in leukemia cells, we herein examined the synergistic effect of cytosolic DNA-sensor signaling activation with conventional differentiation therapy on AML. The combined treatment succeeded in inducing irreversible differentiation in AML cell lines. Mechanistically, cytosolic DNA was sensed by absent in melanoma 2 (AIM2), a cytosolic DNA sensor. Activation of the AIM2 inflammasome resulted in the accumulation of p21 through the inhibition of its proteasomal degradation, thereby facilitating the myeloid differentiation. Importantly, the combined therapy dramatically reduced the total leukemia cell counts and proportion of blast cells in the spleens of AML mice. Collectively, these findings indicate that the autophagy inhibition-cytosolic DNA-sensor signaling axis can potentiate AML differentiation therapy.

Significance:
Clinical effects on AML therapy are closely associated with reactivating the normal myeloid differentiation potential in leukemia cells. This study shows that autophagosome formation inhibitors activate the cytosolic DNA-sensor signaling, thereby augmenting conventional differentiation therapy to induce irreversible differentiation and cell growth arrest in several types of AML cell lines.
Association of Blood Pressure With Brain Ages: A Cohort Study of Gray and White Matter Aging Discrepancy in Mid-to-Older Adults From UK Biobank
Authors: Du Jing , Pan Yuangang , Jiang Jiyang , Liu Yue , Lam Ben C.P. , Schutte Aletta E. , Tsang Ivor W. , Sachdev Perminder S. , Wen Wei 
Published: March 2024

BACKGROUND:
Gray matter (GM) and white matter (WM) impairments are both associated with raised blood pressure (BP), although whether elevated BP is differentially associated with the GM and WM aging process remains inadequately examined.

METHODS:

We included 37 327 participants with diffusion-weighted imaging (DWI) and 39 630 participants with T1-weighted scans from UK Biobank. BP was classified into 4 categories: normal BP, high-normal BP, grade 1, and grade 2 hypertension. Brain age gaps (BAGs) for GM (BAG
GM
) and WM (BAG
WM
) were derived from diffusion-weighted imaging and T1 scans separately using 3-dimensional-convolutional neural network deep learning techniques.

RESULTS:

There was an increase in both BAG
GM
and BAG
WM
with raised BP (
P
<0.05). BAG
WM
was significantly larger than BAG
GM
at high-normal BP (0.195 years older;
P
=0.006), grade 1 hypertension (0.174 years older;
P
=0.004), and grade 2 hypertension (0.510 years older;
P
<0.001), but not for normal BP. Mediation analysis revealed that the association between hypertension and cognitive decline was primarily mediated by WM impairment. Mendelian randomization analysis suggested a causal relationship between hypertension and WM aging acceleration (unstandardized B, 1.780;
P
=0.016) but not for GM (
P
>0.05). Sliding-window analysis indicated the association between hypertension and brain aging acceleration was moderated by chronological age, showing stronger correlations in midlife but weaker associations in the older age.

CONCLUSIONS:
Compared with GM, WM was more vulnerable to raised BP. Our study provided compelling evidence that concerted efforts should be directed towards WM damage in individuals with hypertension in clinical practice.
Disenchantment, Re-enchantment, Magic, and Vestigial Mythologies
Authors: van den Heever Gerhard 
Published: March 2024

Abstract
This essay interacts with the call for papers for the “Magic and Mischief: Text and Practices in Philosophy, Theology, and the Sciences” conference. It is a self-reflection on the theoretical frameworks and definitions guiding projects of reflection and theorising. Breaking the discourse of religion, theology, and science, as well as that of science and magic, down into its discourse-components to get at the speech acts performed, it shows the mythmaking inherent in particular historical understandings of religion and magic, and religion, magic, and science. By performing a kind of archaeology of discourse one gets to see the social, cultural, and political character of the discourse work. And thus, a study of discourse being a site for analysing social formations, the myths of Enlightenment, secularisation, and disenchantment become avenues for understanding the political and socially formative, and the culturally definitive, character of those acts we prefer to call thinking about religion.
The Demise of Science and Religion, and the Return of Theology and Magic
Authors: Tyson Paul 
Published: March 2024

Abstract
Secular modernity is characterised by a knowledge culture that de-magics nature, and separates science from religion. Magic disrupts the nature/supernature dualism of the modern life-world. This article argues that the modern territorialisation of science from religion can no longer be believed, nor is nature/supernature dualism credible. Hence, the recovery of theology as a public domain activity can also bring natural magic back into our knowledge and power culture. Such a re-introduction, the article argues, is essential if we are to try and deliver ourselves from the crassly materialistic instrumentalism that is de-humanising our political landscapes and destroying the natural world.
The Silicon Bough
Authors: Haecker Ryan 
Published: March 2024

Abstract
Like magic wands, words can be spoken through computers to cause effects at a distance. Magic has been suppressed by the rational progress of science to explain the world. Yet in calling upon spiritual intelligences, and in commanding effects to be caused from a distance, computers calculate the programme of mechanical operations that can be relayed at light-speed across the globe. Beyond the ‘digital’ and the ‘postdigital’, the way of writing that has been named the ‘hyperdigital’ is a hyperbolic cybernetic grammar, which, in the sense of a ‘hyperbole’ (ὑπερβολή) or excess of signification, exceeds so as more radically to enter and accelerate through the free use of digital computation and communication. Hyperdigital magic is the art of calling upon the divine and heavenly powers that animate the higher or hyperbolic cybernetic grammar of computers to calculate in writing to cause effects at a distance through no known medium of cumulative action. This chapter will, in Section Two, critique James George Frazer’s narrative supersession of magic into science that has previously withheld magic from computers; in Section Three, recall the computational imaginary of Raymond Llull to recommend a post-Leibnizian Trinitarian Ontology of computers; in Section Four, assimilate the Principle of Sufficient Reason to the higher ground of divine and spiritual freedom; and, in Section Five, present a report on the condition of hyperdigital magic, in which the use of computers appears indistinguishable from magic.