bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTS OF EXERCISE, CREATINE & COQ10 ON MUSCLE FUNCTION IN CHILDREN WITH MYOSITIS
Authors: Lee Yvonne K. , Clairman Hayyah , Baker Kayla M. , Whitney Kristi , Marcuz Jo-Anne , Bell-Peter Audrey , Dover Saunya , Gsell Kelsey , Pullenayegum Eleanor , Schneiderman Jane E , Schulze Andreas , Stephens Samantha , Tein Ingrid , Wells Greg D. , Feldman Brian M. 
Published: February 2025

https://youtu.be/G0PzOreB-PI

BACKGROUND
Juvenile idiopathic inflammatory myopathies (JIIM) are characterized by chronic inflammation of skeletal muscles, muscle weakness and skin rashes. Patients with JIIM have impaired energy metabolism which contributes to the pathophysiology of debilitating muscular symptoms. Creatine (Cr) and Coenzyme Q10 (CoQ10) supplementation, compounds involved in cellular metabolism, has been shown to improve outcomes in musculoskeletal diseases similar to JIIM. Although exercising with Cr supplementation has demonstrated improved muscle function in adults with myositis, its efficacy in children is uncertain. CoQ10 has not yet been used as a therapeutic supplement for myositis. The primary aim of this study was to evaluate whether supplementation with Cr+CoQ10, combined with an exercise program, enhances muscle function in children with juvenile idiopathic inflammatory myopathy (JIIM), as measured by the Wingate Test. Secondary objectives included assessing improvements in vertical jump height, disease activity, and quality of life (QoL), as reported by clinicians, patients, and parents through questionnaires.

METHODS
We recruited 15 patients aged 8-18 from the JIIM specialty clinic at SickKids to participate in a 6-month randomized, double-blind, placebo-controlled, multiple baseline trial. Data were analyzed using a randomization test.

RESULTS
The intervention group demonstrated significant mean differences in peak power (mean difference (MD) = 93.99 Watts; p = 0.0268), mean power (MD = 72.68 Watts; p = 0.0265), and minimum power (MD = 47.29 Watts; p = 0.0119) on the Wingate Test, compared to the placebo group. Additionally, a significant mean difference in vertical jump peak power (MD = 642.91 Watts; p = 0.0145) was observed favoring the intervention. However, these results were not replicated when analyzed using linear mixed models, which account for trends in data before and after the intervention.

CONCLUSION
These results suggest that while the initial findings are promising, even with these significant p-values, they may be due to chance rather than a true effect of the intervention. Further research is needed to explore the impact of creatine and CoQ10 supplementation in children with JIIM.
Tanggung Jawab Pejabat Pembuat Akta Tanah (PPAT) Dalam Pembayaran Pajak Bea Perolehan Hak Atas Tanah dan Bangunan (BPHTB) Atas Transaksi Jual Beli Tanah dan/atau Bangunan di Kota Padang
Authors: Permata Kasman Reta , Khairani  , Syofiarti  
Published: February 2025

PPAT dalam membuat akta terlebih dahulu wajib memastikan Bea Perolehan Hak Aatas Tanah dan Bangunan (BPHTB) tersebut telah dibayar dengan memperlihatkan bukti setoran BPHTB. Ini bertujuan untuk menganalisis Tanggung jawab dan akibat hukum PPAT dalam pembayaran Pajak BPHTB dengan tujuan memberikan efektivitas hukum suatu norma peraturan hukum dapat dilaksanakan mencapai tujuan yang diinginkan dalam masyarakat, termasuk memberikan jasa Pelayanan yang sehubungan pelaksana jabatan seperti mengurus Roya Sertipikat, peningkatan Hak Atas Tanah dari Hak Guna Bangunan Ke Hak Milik. Masyarakat membutuhkan jasa PPAT dalam Perbuatan Peralihan hak atas tanah disamping untuk membuat akta peralihan, juga sekaligus meminta untuk melakukan pengurusan pembayaran pajak baik PPh maupun BPHTB dimana kenyataannya PPAT membantu menyetorkan pajak BPHTB dan PPh yang merupakan kewajiban para pihak, hal tersebut dilakukan dengan menerima surat kuasa bermaterai cukup, dimana hal tersebut melahirkan tangung jawab hukum secara personal kepada PPAT. Metode penelitian ini bersifat deskriptif analisis, dengan menggunakan pendekatan yuridis empiris,menggunakan data primer sebagai bahan utama dengan pengkajian terhadap bahan hukum sekunder. Hasil penelitian ini adalah 1).Tanggungjawab Pejabat Pembuat Akta Tanah (PPAT) dalam pembayaran Pajak BPHTB atas transaksi jual beli tanah, PPAT menyampaikan informasi dan dalam proses pengenaan BPHTB dapat membantu masyarakat dalam menyelesaikan kewajibannya membayar pajak BPHTB sebagai penunjang meningkatkan pendapatan daerah. 2).Sanksi hukum yang diberikan kepada Notaris/PPAT yang melakukan pelanggaran dijelaskan dalam ayat (1) dan ayat (2) Perwako. PPAT yang telah melanggar ketentuan sebagaimana disebutkan dalam Pasal 40 ayat (1) diberikan sanksi administrative berupa denda sebesar Rp.10.000.000,00 untuk setiap pelanggaran. Notaris/PPAT yang melanggar ketentuan sebagaimana disebutkan dalam Pasal 40 ayat (1) dikenakan sanksi administratif berupa denda sebesar Rp. 1.000.000,00 untuk setiap laporan.
Horse Bots
Authors: Kaufman P.E. , Koehler P.G. , Butler J.F. 
Published: February 2025

This document provides an overview of horse bots, Gasterophilus spp., which are internal parasites of horses. It details their biology, life cycle, and seasonal abundance, highlighting the symptoms and damage they cause, such as stomach ulcers and esophageal paralysis. The article also discusses control measures, including grooming, insecticides, and veterinary treatments, to effectively manage horse bot infestations. Originally published as Livestock Protection Pointer Number 8, 1976.
European Honey Bee Apis mellifera Linnaeus and subspecies (Insecta: Hymenoptera: Apidae)
Authors: Mortensen Ashley N. , Schmehl Daniel , Ellis Jamie 
Published: February 2025

This document provides an overview of the European honey bee, Apis mellifera, detailing its natural distribution, subspecies, and introduction to the Americas. It covers the biology, life cycle, and social structure of honey bee colonies, emphasizing the roles of workers, drones, and queens. The article also discusses the economic importance of honey bees in pollination and honey production, as well as management practices and challenges, including pests and diseases. The information is intended for both laypersons with some biological knowledge and academic audiences.
A Mosquito Psorophora ferox (Humboldt 1819) (Insecta: Diptera: Culicidae)
Authors: Holderman Christopher J. , Connelly C. Roxanne 
Published: February 2025

This document provides an in-depth profile of the mosquito species Psorophora ferox, commonly known as the white-footed woods mosquito. Native to North and South America, this mosquito is prevalent in woodland environments with intermittent pools. While it is not a major vector for human pathogens, it is known for its persistent and painful bites. The article details the mosquito’s life cycle, distribution, and medical significance, highlighting its role in transmitting certain viruses in laboratory settings. Management recommendations include avoiding outdoor activities during peak mosquito activity and using EPA-registered repellents.
Detailed genetic analyses highlight genetic variation and genomic regions for lead tolerance in spring wheat
Authors: Mourad Amira M. I. , Sallam Ahmed , Farghaly Khaled A. , Börner Andreas 
Published: February 2025

IntroductionUnderstanding the dynamics of Pb tolerance across different growth stages is essential for breeding wheat varieties with comprehensive tolerance to Pb contamination throughout their life cycle. Lead (Pb) in soil affects wheat plants at all growth stages. However, the seedling stage is considered a sensitive growth stage for the tolerance of most abiotic stresses. Genetic variation in lead tolerance is poorly understood, and genetic control has still not been investigated.MaterialsIn this study, 103 highly diverse wheat genotypes were investigated under normal and lead stress conditions at the seedling stage. Different seedling growth traits were scored under each treatment. GWAS was performed via two different sets of markers: 21,750 (25K Infinium iSelect array) and 37,790 SNPs (genotyping-by-sequencing) to identify SNP markers associated with the studied seedling traits.ResultsHigh genetic variation was found among all the genotypes for all the traits. High broad-sense heritability estimates ranging from 0.25-0.93 were observed. A highly significant correlation was found among all the traits scored under normal and lead stress conditions. Low or no significant phenotypic correlations were found for lead tolerance between the seedling and adult growth stages. A set of eight genotypes were classified as lead-tolerant genotypes. The GWAS revealed a set of 222 significant markers associated with lead tolerance. Markers with pleiotropic effects were detected under Pb stress and between lead and normal conditions. Interestingly, five significant markers were found to be associated with lead tolerance at the seedling and adult growth stages.DiscussionThe results of this study provide new and novel insights into genetic control and genetic variation in lead tolerance at the early growth stage. All the genes and genotypes reported in this study will be very useful for further investigations of lead tolerance in wheat at different growth stages.
Stiffness characteristics of the lower extremities in Women’s Chinese Basketball Association competition athletes: normative values and position differences
Authors: Wang Dan , Wang Zhihai , Yang Mingming , Qu Kaiyuan , Mao Xinyu , Yang Xin , Zhang Zhiye , Shao Che , Delahunt Eamonn , Fang Wenxuan 
Published: February 2025

PurposeHigher stiffenss is expected to augment performance by increasing the utilisation of elastic energy. However, excessive lower extremity stiffness increases the risk of bony injuries; while insufficient stiffness is associated with a higher likelihood of soft tissue injuries. Thus, there might be an ‘optimal’ stiffness value or range that allows for maximising athletic performance while simultaneously minimising risk of sports injury. Basketball players can be classified by position as centres, guards and forwards, with each position characterised by specific injury risks and exercise patterns. Therefore, this study aims to establish normative data for lower extremity stiffness characteristics of players in the Women’s Chinese Basketball Association (WCBA) and compare the characteristics based on position.MethodsA total of 124 WCBA athletes (over 70% of the WCBA teams) were recruited for this study, including 63 forwards, 22 centres and 39 guards. Stiffness was evaluated before and during the 2020–2021 WCBA season, which was averaged for data analysis. Quasi-static stiffness measurements of muscles and tendons were collected via a handheld myometer on seven sites of each leg. Vertical stiffness was also evaluated by OptoGait system.ResultsDescriptive statistics were used to establish the normative values of stiffness for forwards, centres and guards. The Kruskal Wallis test and post hoc Bonferroni pairwise comparisons found significant higher stiffness of the left patellar tendon (PT) in guards than centres (p = 0.004) and in guards than forwards (p = 0.012), right PT stiffness in guards than centres (p = 0.016) and in guards than forwards (p = 0.017), mean PT stiffness in guards than centres (p = 0.003) and in guards than forwards (p = 0.008); stiffness of the right soleus (SOL) in guards than forwards (p = 0.033), stiffness of the left biceps femoris (BF) in forwards than centres (p = 0.049) and in guards than centres (p = 0.038); and stiffness of the left vertical stiffness (hopping) in forwards than centres (p = 0.041).ConclusionForwards, centres and guards were characterised by significantly different stiffness values, which could be utilised for improvement of athletic performance and injury prevention.
Affective-sexual and gender diversity in Spanish education: a systematic literature review
Authors: Ortega-Sánchez Delfín , Sanz de la Cal Esther , Ibáñez Quintana Jaime , Encabo-Fernández Eduardo 
Published: February 2025

IntroductionThe aim of this present work is to systematically compile, map, and review the scientific literature concerning education on affective-sexual and gender diversity, produced within the Spanish geographical context over the past decade (2013–2023). To this end, this systematic review offers an unprecedented and updated synthesis of the most prominent challenges and areas for improvement in Spain, for the purpose of identifying existing research gaps, as well as curricular and training needs in this transdisciplinary field.MethodsTo achieve this objective, the PRISMA guidelines are applied in the extraction and selection of indexed materials from two of the principal internationally renowned databases, namely the Web of Science Core Collection and Scopus. The analysis was facilitated through the use of bibliographic management software, as well as quantitative and qualitative data analysis tools.ResultsThe findings obtained address the research question pertaining to the factors influencing the construction of attitudes and representations concerning this type of diversity within formal educational settings. Furthermore, the benefits, limitations, and obstacles surrounding its curricular integration are examined. Various socio-demographic variables of both students and educators, such as age, gender, religious beliefs, teaching experience, personal and social experiences, school-driven initiatives, and the persistence of hegemonic gender representations emerge as explanatory factors linked to these attitudes and representations. Similarly, the visibility of diverse identities, social inclusion, and plurality are associated with the necessity for education geared toward democratic citizenship. The sensitivity of the content and its curricular invisibility, along with training deficiencies, lack of academic recognition, and the absence of specific protocols for preventing LGBTIQphobia are identified as the most prominent limitations or hurdles for the comprehensive promotion of education pertaining to affective-sexual and gender diversity across distinct educational stages.DiscussionInstances of discrimination, harassment, and both physical and symbolic violence against non-heteronormative groups, grounded in the sex-gender system and cis-heteronormativity, continue to be recognized by educators. In this vein, scientific literature underscores the significance of education concerning affective-sexual and gender diversity as a means to eradicate stereotypes and negative attitudes toward LGBTIQ+ individuals, thereby striving toward genuine equity.
Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers
Authors: Zhang Yongjiao , Chen Ao , Lu Sumei , Liu Dong , Xuan Xiaolei , Lei Xiaofei , Zhong Mingwei , Gao Fei 
Published: February 2025

BackgroundObesity, a prevalent metabolic disorder, is linked to perturbations in the balance of gene expression regulation. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), play pivotal roles in regulating gene expression. The aim of this study was to identify additional ncRNA candidates that are implicated in obesity, elucidating their potential as key regulators of the pathogenesis of obesity.MethodsWe identified distinct ncRNA expression profiles in omental adipose tissue in obese and healthy subjects through comprehensive whole-transcriptome sequencing. Subsequent analyses included functional annotation with GO and KEGG pathway mapping, validation via real-time quantitative polymerase chain reaction (qRT‒PCR), the exploration of protein‒protein interactions (PPIs), and the identification of key regulatory genes through network analysis.ResultsThe results indicated that, compared with those in healthy individuals, various lncRNAs, circRNAs, and miRNAs were significantly differentially expressed in obese subjects. Further verifications of top changed gene expressions proved the most genes’ consistence with RNA-sequencing including 11 lncRNAs and 4 circRNAs. Gene network analysis highlighted the most significant features associated with metabolic pathways, specifically ENST00000605862, ENST00000558885, and ENST00000686149. Collectively, our findings suggest potential ncRNA therapeutic targets for obesity, including ENST00000605862, ENST00000558885, and ENST00000686149.
Residents as learning facilitators inside and outside of interprofessional education: a faculty development program in postgraduate pediatric training
Authors: Müller Philipp A. , Straub Christine , Heinzmann Andrea , Langer Thorsten , Bode Sebastian F. N. , Griewatz Jan , Kimmig Christian , Friedrich Sebastian 
Published: February 2025

IntroductionChanging learning environments in health professions are an important challenge of interprofessional education (IPE). When students experience IPE activities during their undergraduate training, they are often guided by trained learning facilitators. Students still spend more time in non-IPE settings, often guided by residents. Residents rarely undergo specific training for core teaching competencies that are crucial in both IPE and non-IPE contexts. At our pediatric hospital, some residents were trained as learning facilitators on an interprofessional training ward. To bridge the gap between IPE and non-IPE learning facilitation for the other residents, we developed the resident-as-teachers course “How to teach pediatrics.”Methods“How to teach pediatrics” was implemented as a 4-week blended learning program based on the framework of Core Competencies for Medical Teachers (KLM). The intended learning outcomes were to reflect on residents’ role modelling and professionalism as well as personal teaching practice, emphasize learner centeredness and foster social and communicative competencies. Participants self-assessed their teaching competencies pre/post-course using a validated questionnaire (FKM_L). Oral feedback was gathered by group reflection and qualitative feedback by open-ended survey questions.Results26 residents participated in the course, of which N = 22 qualified for the pre/post-course self-assessment via the FKM_L (return rate: n = 9; 40.9%). Participants reported an increase in the competency fields of “didactical activities in medicine,” “social and communicative competence,” “role model and professional behavior” as well as “reflection and further development of own teaching practice.” Participants evaluated the course overall as “very good,” stated a high learning gain and estimated the course to be a good preparation for teaching students.Discussion“How to teach pediatrics” shows the feasibility of integrating faculty development as part of resident training. We observed a self-assessed increase in core competencies for medical teachers after participating in the course. Although more participants need to be included and long-lasting effects still need to be proven, such faculty development programs for learning facilitators might be an opportunity to ensure a more consistent and high-quality learning experience for students in both IPE and non-IPE teaching and learning activities.
Food-related behaviors of rural (Asaase Kooko) and peri-urban (Kaadjanor) households in Ghana
Authors: Osei Prince Kwabena , McCrory Megan A. , Steiner-Asiedu Matilda , Sazonov Edward , Sun Mingui , Jia Wenyan , Baranowski Tom , Frost Gary , Lo Benny , Anderson Alex Kojo 
Published: February 2025

Background“Food-related behaviors” range widely and include food acquisition, storage, cooking, meal sharing, eating practices, among others. Food-related behaviors can influence nutritional status and health outcomes, and likely vary between rural and peri-urban households; however, there is limited documentation on such differences.ObjectiveTo assess food-related behaviors of rural and peri-urban households in Ghana to inform the design and implementation of a field study to validate passive wearable camera technologies for dietary assessment.MethodsThis was a cross-sectional qualitative study in rural (Asaase Kokoo) and peri-urban (Kaadjanor) communities, Ghana. Forty key informants (20 rural and 20 peri-urban) were interviewed about their household food-related behaviors. All interviews were audio-recorded and transcribed verbatim by professional transcribers, and manually coded using the directed content analysis approach.ResultsAll but three key informants were mothers, who were also the main food preparers for their households. The mean (SD) ages of female key informants were 35.5 (19.8) years in rural households and 38.9 (19.2) years in peri-urban households. The ages of two male key informants in rural households were 45 and 60 years, and the age of the only male key informant in a peri-urban household was 53 years. The most prevalent occupation in rural households was farming, while in per-urban households, blue-collar jobs (e.g., beauticians, sales personnel, and commercial drivers) were the main occupations. Farming was the main source of food in rural households, whereas buying food from local markets and grocery stores was the main source of food in peri-urban households. Some in rural and peri-urban households reported that husbands received preferential treatment by being served first with larger meal portions after food preparation in the home. Few key informants in rural households reported that meal-sharing patterns were based on ages of household members, with adults usually served more food than children.ConclusionThe meal-sharing patterns and eating practices reported in some rural and peri-urban households could potentially impact the nutrition and health of children. Our findings suggest the need for nutrition education for mothers to provide adequate and nutrient-rich foods to support optimal child growth and development.
High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT)
Authors: Ding Yuxuan , Feng Yong , Ye Yangfan , Shen Jiayi , Guo Chang , He Xia , Zhu Liangjun , Wang Lijun 
Published: February 2025

IntroductionMicrosatellite stable (MSS) colorectal cancer with liver metastases (CLRM) responds poorly to immunotherapy, and various approaches to break immune tolerance have been tried. Radiotherapy in combination with immune checkpoint inhibitors is one of promising therapies, and the choice of radiotherapy and immunotherapy modalities is also a hot issue.MethodsHere, we report on a Phase I trial treating nine patients with MSS CLRM using a combination of high and low dose radiotherapy and immune checkpoint inhibitors (ICIs).ResultsThe primary endpoint of the trial was the safety and tolerability of this combination treatment modality. Secondary endpoints included the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). The study results showed that at three dose levels—single doses of 6Gy (n=3), 8Gy (n=3), and 10Gy (n=3)—the most common treatment-related adverse events (TRAEs) were nausea, vomiting, fatigue, and abnormal liver function. At the first condition assessment, four patients were observed to have stable disease (SD) and one patient achieved partial response (PR). In exploratory endpoint analyses, tissue biopsies and paired hematologic samples from patients showed M2 macrophage reduction. Plasma cytokines IL-10, IL-17, and INF-α increased after treatment with both drugs.DiscussionIn summary, this is the first clinical trial demonstrating the safety and immunogenic activity of combined high and low dose radiotherapy with ICIs in MSS colorectal cancer liver metastases (CRLMs). The combination therapy stimulated the immune response and altered the tumour microenvironment, warranting further exploration in the future.