bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of chemical markers affecting the occurrence of Panolis flammea Den. & Shiff.
Authors: Rzyska Katarzyna , Szwajkowska‐Michałek Lidia , Przybylska‐Balcerek Anna , Kuźmiński Robert , Świerk Dariusz , Krzyżaniak Michał , Szablewski Tomasz , Cegielska‐Radziejewska Renata , Stuper‐Szablewska Kinga 
Published: March 2024

AbstractThe research conducted so far on the chemical mechanisms of trees' defence against foliophages has not uncovered the chemical compounds biosynthesized by plants that are essential for these mechanisms. The objective of this study was to identify a chemical indicator for the presence of the pine beauty moth in Pinus sylvestris stands. Fresh needled shoots were collected from the crowns of pine trees in stands where the pine beauty moth tends to occur in large numbers, as well as from control stands. Total phenolic contents, total flavonoids contents, total chlorophyll content, terpene compounds, phenolic compound concentration, LMWOAs, sugar content, and colour analysis were conducted. Chlorophyll content, the presence of Panolis flammea in forest stands, and the colour of pine needles were discovered to be related. Variable L* correlated positively with the concentrations of chlorophyll a and b. In pine needles that were not attacked by the pine beauty moth, significantly higher concentrations of 4‐hydroxybenzoic acid, salicylic acid, chlorogenic acid, syringic acid, quercitin, and rutin were found, with the first compound having the most significant effect (4‐hydroxybenzoic acid). Based on the study results, the connected compounds in pine needles make them susceptible to insect attack. In addition, insect repellent programmes were mentioned.
Mortality in patients with chronic hepatitis B treated with tenofovir or entecavir: A multinational study
Authors: Jang Tyng‐Yuan , Liang Po‐Cheng , Jun Dae Won , Jung Jang Han , Toyoda Hidenori , Wang Chih‐Wen , Yuen Man‐Fung , Cheung Ka Shing , Yasuda Satoshi , Kim Sung Eun , Yoon Eileen L , An Jihyun , Enomoto Masaru , Kozuka Ritsuzo , Chuma Makoto , Nozaki Akito , Ishikawa Toru , Watanabe Tsunamasa , Atsukawa Masanori , Arai Taeang , Hayama Korenobu , Ishigami Masatoshi , Cho Yong Kyun , Ogawa Eiichi , Kim Hyoung Su , Shim Jae‐Jun , Uojima Haruki , Jeong Soung Won , Ahn Sang Bong , Takaguchi Koichi , Senoh Tomonori , Buti Maria , Vargas‐Accarino i Elena , Abe Hiroshi , Takahashi Hirokazu , Inoue Kaori , Yeh Ming‐Lun , Dai Chia‐Yen , Huang Jee‐Fu , Huang Chung‐Feng , Chuang Wan‐Long , Nguyen Mindie H , Yu Ming‐Lung 
Published: March 2024

AbstractBackground and AimThe benefits of entecavir (ETV) versus tenofovir disoproxil fumarate (TDF) in reducing the development of chronic hepatitis B (CHB)‐related hepatocellular carcinoma remain controversial. Whether mortality rates differ between patients with CHB treated with ETV and those treated with TDF is unclear.MethodsA total of 2542 patients with CHB treated with either ETV or TDF were recruited from a multinational cohort. A 1:1 propensity score matching was performed to balance the differences in baseline characteristics between the two patient groups. We aimed to compare the all‐cause, liver‐related, and non‐liver‐related mortality between patients receiving ETV and those receiving TDF.ResultsThe annual incidence of all‐cause mortality in the entire cohort was 1.0/100 person‐years (follow‐up, 15 757.5 person‐years). Patients who received TDF were younger and had a higher body mass index, platelet count, hepatitis B virus deoxyribonucleic acid levels, and proportion of hepatitis B e‐antigen seropositivity than those who received ETV. The factors associated with all‐cause mortality were fibrosis‐4 index > 6.5 (hazard ratio [HR]/confidence interval [CI]: 3.13/2.15–4.54, P < 0.001), age per year increase (HR/CI: 1.05/1.04–1.07, P < 0.001), alanine aminotransferase level per U/L increase (HR/CI: 0.997/0.996–0.999, P = 0.003), and γ‐glutamyl transferase level per U/L increase (HR/CI: 1.002/1.001–1.003, P < 0.001). No significant difference in all‐cause mortality was observed between the ETV and TDF groups (log–rank test, P = 0.69). After propensity score matching, no significant differences in all‐cause, liver‐related, or non‐liver‐related mortality were observed between the two groups.ConclusionsLong‐term outcomes of all‐cause mortality and liver‐related and non‐liver‐related mortality did not differ between patients treated with ETV and those receiving TDF.
Retentiveness of rare earth elements in garnet with implications for garnet Lu‐Hf chronology
Authors: Smit Matthijs A. , Vrijmoed Johannes C. , Scherer Erik E. , Mezger Klaus , Kooijman Ellen , Schmitt‐Kielman Melanie , Tual Lorraine , Guilmette Carl , Ratschbacher Lothar 
Published: March 2024

AbstractIncorporation of rare earth elements (REE) in garnet enables garnet chronology (Sm‐Nd, Lu‐Hf), and imparts a garnet‐stable signature on cogenetic phases, which allows petrochronology and general petrogenetic tracing of garnet stability in minerals and melts. Constraints on the uptake and redistribution mechanisms, as well as on the diffusive behaviour of REE in garnet are required for allowing accurate interpretation of REE signatures and ages. Garnet REE profiles are often measured to gain insight into the nature and cause of REE zoning. Interpretation of such profiles is nevertheless complicated by poor constraints on the extent of diffusive relaxation. This is especially relevant for Lu, which, according to experiments, has a relatively high diffusivity and thus may re‐equilibrate with possible consequences for Lu‐Hf chronology. To provide new insight into the REE systematics of garnet, we applied quantitative trace‐element mapping of garnet grains from metamorphic rocks that record peak temperatures above 750°C and cooling rates as low as 1.5°C Ma−1. Garnet in all samples preserves Rayleigh‐type or oscillatory growth zoning with sharply defined interfacial angles that match the garnet habit. Re‐equilibration of REE compositions appears restricted to domains with nebulous and patchy zoning, which likely form by interface‐coupled dissolution and re‐precipitation reactions mediated by fluids or melts, rather than REE volume diffusion. The possible effect of Lu diffusion in the analysed grains was investigated by comparing the observations to the results from 2D numerical modelling using Lu diffusivities from recent diffusion experiments. This test indicates that Lu diffuses significantly slower in natural garnet than experiments predict. The retentiveness of REE in garnet demonstrates the reliability of REE signatures in magmatic tracing and petrochronology and establishes Lu‐Hf chronology as a robust means of dating garnet growth and recrystallization in metamorphic rocks, including those that underwent high‐ or ultrahigh‐temperature conditions.
The role of the beautician in reducing striae
Authors: Rusztowicz Monika , Chilicka Karolina , Gold Michael H. , Szyguła Renata , Wilczyński Sławomir , Błońska‐Fajfrowska Barbara 
Published: March 2024

AbstractIntroductionStriae distensae are a permanent skin defect that can affect 50%–90% of the population. The appearance of the changes resembles spindle‐shaped skin bands. The skin in this area is wrinkled, thin and looks like a scar. Most often, the changes are found on the skin of the abdomen, buttocks, breasts, thighs, and back. The appearance of striae means that the skin in this area has no hair follicles, sebaceous, and sweat glands. This skin is flabby, not very elastic and, what is very characteristic, the pigmentation of the skin affected by striae is much lower than in healthy skin. Cosmetology in the 21st century is developing very dynamically, new technologies are being developed, new cosmetological devices are being created and combined with treatments that have been known for a long time. Today's science offers hope for people who have struggled with reducing striae for many years and nowadays, nothing is impossible.AimsThe objective of this article is to provide information about cosmetological treatment used to reduce striae.MethodsIn this article, we reviewed the published literature, article published in peer‐reviewed journals.ResultsToday's cosmetology offers a wide range of numerous treatments, but the best results are achieved through a synergy of two or more treatments. But we should not forget that we should respond to each customer individually.ConclusionThe striae are not a problem that should be ignored. The beauty therapist is able to reduce them and help the client to improve the appearance of their skin.
The impact of electronic and self‐rostering systems on healthcare organisations and healthcare workers: A mixed‐method systematic review
Authors: O'Connell Martina , Barry Jane , Hartigan Irene , Cornally Nicola , Saab Mohamad M. 
Published: March 2024

AbstractAimTo synthesise evidence from studies that explored the impact of electronic and self‐rostering systems to schedule staff on healthcare organisations and healthcare workers.DesignMixed‐method systematic review.MethodsStudies were screened by two independent reviewers and data were extracted using standardised data extraction tables. The quality of studies was assessed, and parallel‐results convergent synthesis was conducted.Data SourcesAcademic Search Complete, CINAHL, ERIC, MEDLINE, PsycINFO and PsycARTICLES were searched on January 3, 2023.ResultsEighteen studies were included (10 quantitative descriptive studies, seven non‐randomised studies and one qualitative study). Studies examined two rostering interventions including self‐rostering (n = 12) and electronic rostering (n = 6). It was found that the implementation of electronic and self‐rostering systems for staff scheduling impacted positively on both, healthcare workers and healthcare organisations. Benefits included enhanced roster efficiency, staff satisfaction, greater control and empowerment, improved work‐life balance, higher staff retention and reduced turnover, decreased absence rates and enhanced healthcare efficiency. However, self‐rostering was found to be less equitable than fixed rostering, was associated with increased overtime, and correlated with a higher frequency of staff requests for shift changes.ConclusionThe impact of electronic and self‐rostering systems to schedule staff on healthcare organisations and healthcare workers’ outcomes was predominantly positive. Further randomised controlled trials and longitudinal studies are warranted to evaluate the long‐term impact of various rostering systems, including electronic and self‐rostering systems.Implications for HealthcareRostering is a multifaceted responsibility for healthcare administrators, impacting patient care quality, workforce planning and healthcare expenditure.ImpactGiven that healthcare staffing costs constitute a substantial portion of global healthcare expenditure, efficient and strategic resource management, inclusive of healthcare staff rostering, is imperative.Reporting MethodThe 27‐item Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) checklist.Patient or Public ContributionNo Patient or Public Contribution.
Lenvatinib plus pembrolizumab in the patients with advanced previously treated endometrial cancer: A cost‐effectiveness analysis in the United States and in China
Authors: Liao Xiaodong , Wu Yajing , Lin Dong , Gu Dian , Luo Shaohong , Huang Xiaoting , Xu Xiongwei , Weng Xiuhua , Lin Shen 
Published: March 2024

AbstractPurposeTo investigate the cost‐effectiveness of lenvatinib plus pembrolizumab (LP) compared to chemotherapy as a second‐line treatment for advanced endometrial cancer (EC) from the United States and Chinese payers' perspective.MethodsIn this economic evaluation, a partitioned survival model was constructed from the perspective of the United States and Chinese payers. The survival data were derived from the clinical trial (309‐KEYNOTE‐775), while costs and utility values were sourced from databases and published literature. Total costs, quality‐adjusted life years (QALYs) and incremental cost‐effectiveness ratio (ICER) were estimated. The robustness of the model was evaluated through sensitivity analyses, and price adjustment scenario analyses was also performed.ResultsBase‐case analysis indicated that LP wouldn't be cost‐effective in the United States at the WTP threshold of $200 000, with improved effectiveness of 0.75 QALYs and an additional cost of $398596.81 (ICER $531392.20). While LP was cost‐effective in China, with improved effectiveness of 0.75 QALYs and an increased overall cost of $62270.44 (ICER $83016.29). Sensitivity analyses revealed that the above results were stable. The scenario analyses results indicated that LP was cost‐effective in the United States when the prices of lenvatinib and pembrolizumab were simultaneously reduced by 61.95% ($26.5361/mg for lenvatinib and $19.1532/mg for pembrolizumab).ConclusionLP isn't cost‐effective in the patients with advanced previously treated endometrial cancer in the United States, whereas it is cost‐effective in China. The evidence‐based pricing strategy provided by this study could benefit decision‐makers in making optimal decisions and clinicians in general clinical practice. More evidence about budget impact and affordability for patients is needed.
Interview: A Childhood Story of Growth and Self‐Discovery: 20,000 Species of Bees
Authors: Genç Seray 
Published: March 2024

AbstractEstibaliz Urresola Solaguren, born on May 4, 1984, in Llodio, Álava, is a film director, screenwriter, and producer from the Basque Country, Spain. Her works include the documentary “Voces de papel” (2016) and the short film “Cuerdas” (2022). However, it is her first feature film, “20,000 species of bees” (2023), that earned widespread acclaim and won awards at various film festivals. This film delves into the challenges faced by a family with a transgender girl, drawing inspiration from the tragic story of Ekai Lersundi. Urresola's aspiration was to evoke empathy for the struggles of transgender individuals, fueled by the hope for societal change. The film's compelling narrative revolves around 8‐year‐old Cocó's journey of self‐discovery, challenging societal expectations and prompting his mother, Ane, to confront her own doubts and fears during a transformative summer spent with family.
Family obligation in Chinese adolescents: Consequences and parental antecedents
Authors: Yang Beiming , Chen Bin‐Bin , Chen Xiaochen , Hu Zhan , Qu Yang 
Published: March 2024

AbstractAdolescents' family obligation is a cultural strength that shows enduring prevalence in China. Given that the meaning of family obligation has undergone rapid changes in recent decades, it is crucial to examine the role of family obligation in adolescent adjustment in contemporary China. More importantly, although past research has investigated the consequences of family obligation on adolescents' adjustment, little is known about the antecedents of Chinese adolescents' family obligation. Using a two‐wave longitudinal sample of 450 Chinese adolescents (mean age = 13.78 years, SD = .71 years; 49% female) and their parents, the current research explored two questions. First, this study examined the role of family obligation in adolescents' academic achievement, externalizing problems, and internalizing problems over early adolescence. Second, this study explored the role of parents in predicting Chinese adolescents' family obligation, specifically whether parental expectations or parental acceptance was predictive of adolescents' family obligation over time. Third, this study investigated whether family obligation is an underlying mechanism between parenting and Chinese adolescents' adjustment. Results showed that Chinese adolescents' family obligation was longitudinally associated with increased academic achievement and reduced externalizing problems. Moreover, perceived parental acceptance, but not parental expectations, was longitudinally associated with Chinese adolescents' greater family obligation. Notably, family obligation mediated the longitudinal effect of parental acceptance on Chinese adolescents' externalizing problems. By studying both the consequences and antecedents of Chinese adolescents' family obligation, this study helps provide a comprehensive understanding of this cultural strength.
A photoresponsive recombinant human amelogenin‐loaded hyaluronic acid hydrogel promotes bone regeneration
Authors: Hsia Tung‐Liang , Lin Zhikai , Xia Yiru , Shu Rong , Xie Yufeng 
Published: March 2024

AbstractObjectivesIn order to evaluate the effect of methacrylated hyaluronic acid (HAMA) hydrogels containing the recombinant human amelogenin (rhAm) in vitro and in vivo.BackgroundThe ultimate goal in treating periodontal disease is to control inflammation and achieve regeneration of periodontal tissues. In recent years, methacrylated hyaluronic acid (HAMA) containing recombinant human amyloid protein (rhAm) has been widely used as a new type of biomaterial in tissue engineering and regenerative medicine. However, there is a lack of comprehensive research on the periodontal regeneration effects of this hydrogel. This experiment aims to explore the application of photoresponsive recombinant human amelogenin‐loaded hyaluronic acid hydrogel for periodontal tissue regeneration and provide valuable insights into its potential use in this field.Materials and MethodsThe effects of rhAm‐HAMA hydrogel on the proliferation of human periodontal ligament cells (hPDLCs) were assessed using the CCK‐8 kit. The osteogenic differentiation of hPDLCs was evaluated through ALP staining and real‐time PCR. Calvarial parietal defects were created in 4‐week‐old Sprague Dawley rats and implanted with deproteinized bovine bone matrix in different treatment groups. The animals were euthanized after 4 and 8 weeks of healing. The bone volume of the defect was observed by micro‐CT and histological analysis.ResultsStimulating hPDLCs with rhAm‐HAMA hydrogel did not significantly affect their proliferation (p > .05). ALP staining and real‐time PCR results demonstrated that the rhAm‐HAMA group exhibited a significant upregulation of osteoclastic gene expression (p < .05). Micro‐CT results revealed a significant increase in mineralized tissue volume fraction (MTV/TV%), trabecular bone number (Tb.N), and mineralized tissue density (MTD) of the bone defect area in the rhAm‐HAMA group compared to the other groups (p < .05). The results of hematoxylin and eosin staining and Masson staining at 8 weeks post‐surgery further supported the results of the micro‐CT.ConclusionsThe results of this study indicate that rhAm‐HAMA hydrogel could effectively promote the osteogenic differentiation of hPDLCs and stabilize bone substitutes in the defects that enhance the bone regeneration in vivo.
Assessment of the status of selected heavy metals in water, sediments and a fish species (Oreochromis niloticus) of commercial value in Lake Nakuru with a focus on human health risks
Authors: Nantongo Mary Florence , Edebe Joseph , Otachi Elick O. , Kipkemboi Julius 
Published: March 2024

AbstractThe present study presents selected water quality parameters and the levels of heavy metals in water, sediments and Nile tilapia (Oreochromis niloticus) of Lake Nakuru. Nine sediments and nine water samples, as well as 30 specimens of Nile tilapia, were collected from the northern part of the lake. Physical parameters were measured in situ using multiple probes and metres. Heavy metals were analysed using an atomic absorption spectrophotometer (AAS). The pH, dissolved oxygen concentration, temperature, salinity and electrical conductivity ranged from 9.52 to 9.72, 4.58 to 8.62 mg/L, 23.40°C to 25.7°C, 2.39‰ to 2.81‰ and 4470–5226 μs/cm, respectively. Heavy metal levels (mean ± SD) were generally low in the water samples. Chromium values ranged between 7.16 and 9.19 mg/kg dw in sediment samples, and between 3.7 and 13.06 mg/kg dw in fish samples. Lead values ranged between 12.5 and 31.04 mg/kg dw in sediment samples and 4.06 and 9.95 mg/kg dw in fish samples. Arsenic values ranged between 9.5 and 21.7 mg/kg dw in sediments and below detectable limit to 2.11 mg/kg dw in fish samples. Mercury values ranged between .14 and .31 mg/kg dw in sediment samples and .12 and .35 mg/kg dw in fish samples. Cadmium was the only heavy metal concentration that was below the detection limit in the three matrices. Significant differences were observed for some heavy metal concentrations in water, sediments and fish across sites (p < .05). The levels of lead and chromium in fish were above the East African Standard, World Health Organization and European Union limits. The results of the present study recommend a possible reclassification of the lake, an immediate ban on fish harvesting and consumption from Lake Nakuru and a policy intervention on the fishery and pollution management.
miR164‐MhNAC1 regulates apple root nitrogen uptake under low nitrogen stress
Authors: Wang Xiaona , Zhou Yan , Chai Xiaofen , Foster Toshi M. , Deng Cecilia H. , Wu Ting , Zhang Xinzhong , Han Zhenhai , Wang Yi 
Published: March 2024

Summary

Nitrogen is an essential nutrient for plant growth and serves as a signaling molecule to regulate gene expression inducing physiological, growth and developmental responses. An excess or deficiency of nitrogen may have adverse effects on plants. Studying nitrogen uptake will help us understand the molecular mechanisms of utilization for targeted molecular breeding.

Here, we identified and functionally validated an NAC (NAM‐ATAF1/2‐CUC2) transcription factor based on the transcriptomes of two apple rootstocks with different nitrogen uptake efficiency. NAC1, a target gene of miR164, directly regulates the expression of the high‐affinity nitrate transporter (MhNRT2.4) and citric acid transporter (MhMATE), affecting root nitrogen uptake.

To examine the role of MhNAC1 in nitrogen uptake, we produced transgenic lines that overexpressed or silenced MhNAC1. Silencing MhNAC1 promoted nitrogen uptake and citric acid secretion in roots, and enhanced plant tolerance to low nitrogen conditions, while overexpression of MhNAC1 or silencing miR164 had the opposite effect.

This study not only revealed the role of the miR164‐MhNAC1 module in nitrogen uptake in apple rootstocks but also confirmed that citric acid secretion in roots affected nitrogen uptake, which provides a research basis for efficient nitrogen utilization and molecular breeding in apple.
Sirt5‐mediated lysine desuccinylation regulates oxidative stress adaptation in Magnaporthe oryzae during host intracellular infection
Authors: Ren Zhiyong , Dong Xiang , Guan Lun , Yang Lei , Liu Caiyun , Cai Xuan , Hu Hong , Lv Ziwei , Liu Hao , Zheng Lu , Huang Junbin , Wilson Richard A. , Chen Xiao‐Lin 
Published: March 2024

Summary

Plant pathogenic fungi elaborate numerous detoxification strategies to suppress host reactive oxygen species (ROS), but their coordination is not well‐understood.

Here, we show that Sirt5‐mediated protein desuccinylation in Magnaporthe oryzae is central to host ROS detoxification. SIRT5 encodes a desuccinylase important for virulence via adaptation to host oxidative stress. Quantitative proteomics analysis identified a large number of succinylated proteins targeted by Sirt5, most of which were mitochondrial proteins involved in oxidative phosphorylation, TCA cycle, and fatty acid oxidation.

Deletion of SIRT5 resulted in hypersuccinylation of detoxification‐related enzymes, and significant reduction in NADPH : NADP+ and GSH : GSSG ratios, disrupting redox balance and impeding invasive growth. Sirt5 desuccinylated thioredoxin Trx2 and glutathione peroxidase Hyr1 to activate their enzyme activity, likely by affecting proper folding.

Altogether, this work demonstrates the importance of Sirt5‐mediated desuccinylation in controlling fungal process required for detoxifying host ROS during M. oryzae infection.