bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo‐Sensitizer Evokes Mutually Reinforcing "Closed‐Loop" Ferroptosis and Immunotherapy
Authors: Ren Qingyan , Wang Haobing , Li Dan , Dao Anyi , Luo Jiajun , Wang Deliang , Zhang Pingyu , Huang Huaiyi 
Published: April 2024

AbstractThe hypoxic microenvironment of solid tumors severely lowers the efficacy of oxygen‐dependent photodynamic therapy (PDT). The development of hypoxia‐tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re‐TTPY) to develop a “closed‐loop” therapy based on PDT‐induced ferroptosis and immune therapy is reported. Due to its electron donor–acceptor (D–A) structure, Re‐TTPY undergoes energy transfer and electron transfer processes under 550 nm light irradiation and displays hypoxia‐tolerant type I/II combined PDT capability, which can generate 1O2, O2−, and ·OH simultaneously. Further, the reactive oxygen species (ROSs) leads to the depletion of 1,4‐dihydronicotinamide adenine dinucleotide (NADH), glutathione peroxidase 4 (GPX4), and glutathione (GSH). As a result, ferroptosis occurs in cells, simultaneously triggers immunogenic cell death (ICD), and promotes the maturation of dendritic cells (DCs) and infiltration of T cells. The release of interferon‐γ (IFN‐γ) by CD8+ T cells downregulates the expression of GPX4, further enhancing the occurrence of ferroptosis, and thereby, forming a mutually reinforcing “closed‐loop” therapeutic approach.
Tailoring Oxygen Reduction Reaction Kinetics of Fe−N−C Catalyst via Spin Manipulation for Efficient Zinc–Air Batteries
Authors: Zhang Huiwen , Chen Hsiao‐Chien , Feizpoor Solmaz , Li Linfeng , Zhang Xia , Xu Xuefei , Zhuang Zechao , Li Zhishan , Hu Wenyu , Snyders Rony , Wang Dingsheng , Wang Chundong 
Published: April 2024

AbstractThe interaction between oxygen species and metal sites of various orbitals exhibits intimate correlation with the oxygen reduction reaction (ORR) kinetics. Herein, a new approach for boosting the inherent ORR activity of atomically dispersed Fe−N−C matrix is represented by implanting Fe atomic clusters nearby. The as‐prepared catalyst delivers excellent ORR activity with half‐wave potentials of 0.78 and 0.90 V in acidic and alkaline solutions, respectively. The decent ORR activity can also be validated from the high‐performance rechargeable Zn–air battery. The experiments and density functional theory calculations reveal that the electron spin‐state of monodispersed Fe active sites is transferred from the low spin (LS, t2g6 eg0) to the medium spin (MS, t2g5 eg1) due to the involvement of Fe atomic clusters, leading to the spin electron filling in σ∗ orbit, by which it favors OH− desorption and in turn boosts the reaction kinetics of the rate‐determining step. This work paves a solid way for rational design of high‐performance Fe‐based single atom catalysts through spin manipulation.
Toward Ultrahigh Rate and Cycling Performance of Cathode Materials of Sodium Ion Battery by Introducing a Bicontinuous Porous Structure
Authors: Tang Chen , Lu Wei , Zhang Yixiao , Zhang Wenwei , Cui Congcong , Liu Pan , Han Lu , Qian Xiaoshi , Chen Liwei , Xu Fugui , Mai Yiyong 
Published: April 2024

AbstractThe emerging sodium‐ion batteries (SIBs) are one of the most promising candidates expected to complement lithium‐ion batteries and diversify the battery market. However, the exploitation of cathode materials with high‐rate performance and long‐cycle stability for SIBs has remained one of the major challenges. To this end, an efficient approach to enhance rate and cycling performance by introducing an ordered bicontinuous porous structure into cathode materials of SIBs is demonstrated. Prussian blue analogues (PBAs) are selected because they are recognized as a type of most promising SIB cathode materials. Thanks to the presence of 3D continuous channels enabling fast Na+ ions diffusion as well as the intrinsic mechanical stability of bicontinuous architecture, the resultant PBAs exhibit excellent rate capability (80 mAh g−1 at 2.5 A g−1) and ultralong cycling life (>3000 circulations at 0.5 A g−1), reaching the top performance of the reported PBA‐based cathode materials. This study opens a new avenue for boosting sluggish ion diffusion kinetics in electrodes of rechargeable batteries and also provides a new paradigm for solving the dilemma that electrodes’ failure due to high‐stress concentration upon ion storage.
Titanium Substitution Facilitating Oxygen and Manganese Redox in Sodium Layered Oxide Cathode
Authors: Zhou Junhua , Hu Huimin , Wang Jiaqi , Shi Qitao , Lian Xueyu , Liu Lijun , Bachmatiuk Alicja , Sun Jingyu , Yang Ruizhi , Choi Jin‐Ho , Rümmeli Mark H. 
Published: April 2024

AbstractSodium layered oxide with anion redox activity (SLO‐A) stands out as a promising cathode material for sodium‐ion batteries due to its impressive capacity and high voltage resulting from Mn‐ and O‐redox processes. However, the SLO‐A faces significant challenges in cycling stability and rate performance, primarily due to the poor reversibility and sluggish kinetics of the O‐redox. In this study,a novel Ti‐doped material, Na2/3Li2/9Mn53/72Ti1/24O2 (NLMTO), exhibiting remarkable characteristics such as a notable rate capacity (130 mAh g−1 at 3C, where 1C equals 200 mA g−1) and excellent cycling retention (85.4% after 100 cycles at 0.5C) is introduced. Employing electrochemical differential analyses, the contributions to the superior performance arising from the Mn‐ and O‐redox processes are quantitatively delineated. The optimized performance of NLMTO is attributed, in part, to the enhanced stability of both bulk and interface structures. The introduction of Ti through substitution not only contributes to this stability but also allows for the fine‐tuning of the material's electron configurations. This is achieved by augmenting the density of states near the Fermi energy level, as well as elevating the O 2p and Mn 3d orbits. This research advances sodium‐ion battery technology.
Photocatalyzed Formation of gem‐Difluoroalkenes Using Oxime Esters
Authors: Geniller Lilian , Taillefer Marc , Clot Eric , Jaroschik Florian , Prieto Alexis 
Published: April 2024

AbstractIn this manuscript a general photocatalytic approach for the synthesis of alkyl‐substituted gem‐difluoroalkenes using readily available oxime esters and 1‐bromo‐1,1‐difluoroprop‐2‐ene (BDFP) has been established. This strategy involving a radical bromo elimination provides access to a large variety of value‐added fluorinated molecules. The mild reaction conditions are compatible with many functional groups including complex natural products or drug molecules. Experimental and theoretical mechanistic investigations indicate that the efficiency of the process relies on the crucial role of imine radical, which is formed after photoexcitation via energy transfert (EnT) and decarboxylation of the oxime ester. Indeed, the imine radical would either behave as a bromine radical scavenger or an XAT promoter in this reaction.
Artificial intelligence based on falling in older people: A bibliometric analysis
Authors: Yenişehir Semiha 
Published: April 2024

AbstractObjectivesThis study aimed to analyze publications on artificial intelligence (AI) for falls in older people from a bibliometric perspective.MethodsThe Web of Science database was searched for titles of English‐language articles containing the words “artificial intelligence,” “deep learning,” “machine learning,” “natural language processing,”, “neural artificial network,” “fall,” “geriatric,” “elderly,” “aging,” “older,” and “old age.” An R‐based application (Biblioshiny for bibliometrics) and VOSviewer software were used for analysis.ResultsThirty‐seven English articles published between 2018 and 2024 were included. The year 2023 is the year with the most publications with 16 articles. The most productive research field was “Engineering Electrical Electronic” with seven articles. The most productive country was the United States, followed by China. The most common words were “injuries,” “people,” and “risk factors.”ConclusionPublications on AI and falls in the elderly are both few in number and the number of publications has increased in recent years. Future research should include relevant analyses in scientific databases, such as Scopus and PubMed.
An urgent call to address work‐related psychosocial hazards and improve worker well‐being
Authors: Schulte Paul A. , Sauter Steven L. , Pandalai Sudha P. , Tiesman Hope M. , Chosewood Lewis C. , Cunningham Thomas R. , Wurzelbacher Steven J. , Pana‐Cryan Rene , Swanson Naomi G. , Chang Chia‐Chia , Nigam Jeannie A. S. , Reissman Dori B. , Ray Tapas K. , Howard John 
Published: April 2024

AbstractWork‐related psychosocial hazards are on the verge of surpassing many other occupational hazards in their contribution to ill‐health, injury, disability, direct and indirect costs, and impact on business and national productivity. The risks associated with exposure to psychosocial hazards at work are compounded by the increasing background prevalence of mental health disorders in the working‐age population. The extensive and cumulative impacts of these exposures represent an alarming public health problem that merits immediate, increased attention. In this paper, we review the linkage between work‐related psychosocial hazards and adverse effects, their economic burden, and interventions to prevent and control these hazards. We identify six crucial societal actions: (1) increase awareness of this critical issue through a comprehensive public campaign; (2) increase etiologic, intervention, and implementation research; (3) initiate or augment surveillance efforts; (4) increase translation of research findings into guidance for employers and workers; (5) increase the number and diversity of professionals skilled in preventing and addressing psychosocial hazards; and (6) develop a national regulatory or consensus standard to prevent and control work‐related psychosocial hazards.
Atomic Ruthenium‐Promoted Cadmium Sulfide for Photocatalytic Production of Amino Acids from Biomass Derivatives
Authors: Li Wulin , Zheng Xiuhui , Xu Bei‐Bei , Yang Yue , Zhang Yifei , Cai Lingchao , Wang Zhu‐Jun , Yao Ye‐Feng , Nan Bing , Li Lina , Wang Xue‐Lu , Feng Xiang , Antonietti Markus , Chen Zupeng 
Published: April 2024

AbstractAmino acids are the building blocks of proteins and are widely used as important ingredients for other nitrogen‐containing molecules. Here, we report the sustainable production of amino acids from biomass‐derived hydroxy acids with high activity under visible‐light irradiation and mild conditions, using atomic ruthenium‐promoted cadmium sulfide (Ru1/CdS). On a metal basis, the optimized Ru1/CdS exhibits a maximal alanine formation rate of 26.0 molAla ⋅ gRu−1 ⋅ h−1, which is 1.7 times and more than two orders of magnitude higher than that of its nanoparticle counterpart and the conventional thermocatalytic process, respectively. Integrated spectroscopic analysis and density functional theory calculations attribute the high performance of Ru1/CdS to the facilitated charge separation and O−H bond dissociation of the α‐hydroxy group, here of lactic acid. The operando nuclear magnetic resonance further infers a unique “double activation” mechanism of both the CH−OH and CH3−CH−OH structures in lactic acid, which significantly accelerates its photocatalytic amination toward alanine.
Silica Confinement for Stable and Magnetic Co−Cu Alloy Nanoparticles in Nitrogen‐Doped Carbon for Enhanced Hydrogen Evolution
Authors: Wan Chao , Li Rong , Wang Jiapei , Cheng Dang‐guo , Chen Fengqiu , Xu Lixin , Gao Mingbin , Kang Yunqing , Eguchi Miharu , Yamauchi Yusuke 
Published: April 2024

AbstractAmmonia borane (AB) with 19.6 wt % H2 content is widely considered a safe and efficient medium for H2 storage and release. Co‐based nanocatalysts present strong contenders for replacing precious metal‐based catalysts in AB hydrolysis due to their high activity and cost‐effectiveness. However, precisely adjusting the active centers and surface properties of Co‐based nanomaterials to enhance their activity, as well as suppressing the migration and loss of metal atoms to improve their stability, presents many challenges. In this study, mesoporous‐silica‐confined bimetallic Co−Cu nanoparticles embedded in nitrogen‐doped carbon (CoxCu1−x@NC@mSiO2) were synthesized using a facile mSiO2‐confined thermal pyrolysis strategy. The obtained product, an optimized Co0.8Cu0.2@NC@mSiO2 catalyst, exhibits enhanced performance with a turnover frequency of 240.9 molH2 ⋅ molmetal ⋅ min−1 for AB hydrolysis at 298 K, surpassing most noble‐metal‐free catalysts. Moreover, Co0.8Cu0.2@NC@mSiO2 demonstrates magnetic recyclability and extraordinary stability, with a negligible decline of only 0.8 % over 30 cycles of use. This enhanced performance was attributed to the synergistic effect between Co and Cu, as well as silica confinement. This work proposes a promising method for constructing noble‐metal‐free catalysts for AB hydrolysis.
Adaptations to sociality in the mimetic and auricular musculature of the African wild dog (Lycaon pictus)
Authors: Smith Heather F. , Felix Mia A. , Rocco Felicia A. , Lynch Leigha M. , Valdez Dominik 
Published: April 2024

AbstractThe African wild dog (Lycaon pictus) is a highly social canid that engages in sophisticated, coordinated group hunting tactics to procure large game. It is one of the most effective hunters of the African savannah, due to its highly developed communication methods. It also has large, mobile ears which enhance its auditory capabilities while hunting and assist with thermoregulation. Recent research suggested that certain muscles of facial expression, particularly those involved with expressive eyebrow movement, evolved solely in domestic dogs (Canis familiaris) to facilitate communication with their human owners. However, it is unclear whether highly social wild canid species may also employ similar expressive eye communication. We performed detailed dissections of an adult male L. pictus to evaluate and describe its mimetic and auricular musculature. Overall, L. pictus has well‐developed facial and ear muscles. Musculi levator anguli oculi medialis (LAOM) and retractor anguli oculi lateralis (RAOL), mimetic muscles of hypothesized importance in domestic dog‐human non‐verbal communication, are enlarged in L. pictus, comparable in size to those of domestic dogs, as is m. orbicularis oculi. This morphology suggests that ocular facial expressions contribute to within‐pack communication in wild dogs and are not unique to domestic dogs. The auricular muscles of L. pictus are well‐developed, supporting greater leverage and fine manipulation of its large, mobile ears. These muscular adaptations facilitate the highly social ecology of African wild dogs and challenge current interpretations about the unique nature of domestic dog facial expressions.
Who was the real sabertooth predator: Thylacosmilus or Thylacoleo?
Authors: Janis Christine M. 
Published: April 2024

AbstractSabertoothed mammalian predators, all now extinct, were almost exclusively feloid carnivorans (Eutheria, Placentalia): here a couple of extinct metatherian predators are considered in comparison with the placental sabertooths. Thylacosmilus (the “marsupial sabertooth”) and Thylacoleo (the “marsupial lion”) were both relatively large (puma‐sized) carnivores of the Plio‐Pleistocene in the Southern Hemisphere (Argentina and Australia, respectively). Both carnivores have captured the public imagination, especially as predators that were somehow analogous to northern placental forms. But a more detailed consideration of their morphology shows that neither can be simply analogized with its supposed placental counterpart. While Thylacosmilus did indeed have saber‐like canines, many aspects of its anatomy show that it could not have killed prey in the manner proposed for the sabertoothed felids such as Smilodon. Rather than being an active predator, it may have been a specialized scavenger, using the hypertrophied canines to open carcasses, and perhaps deployed a large tongue to extract the innards. Thylacoleo lacked canines, and its supposedly “caniniform” incisors could not have acted like a felid's canines. Nevertheless, while its mode of dispatching its prey remains a subject for debate, it was clearly a powerful predator, likely to be capable of bringing down prey bigger than itself while hunting alone. In that regard, it may have filled the ecomorphological role proposed for placental sabertooths, and so despite the lack of canines can be nominated as the true “marsupial sabertooth” out of the two extinct taxa.
Semiautomated design and soluble expression of a chimeric antigen TbpAB01 from Glaesserella parasuis
Authors: Chen Jin‐Ping , Zhou Lin , Gong Jin‐Song , Wang Nan‐Kai , Miao Fen‐Fang , Su Chang , Gao Xin‐Le , Xu Guo‐Qiang , Shi Jin‐Song , Xu Zheng‐Hong 
Published: April 2024

AbstractPathogenic bacterial membrane proteins (MPs) are a class of vaccine and antibiotic development targets with widespread clinical application. However, the inherent hydrophobicity of MPs poses a challenge to fold correctly in living cells. Herein, we present a comprehensive method to improve the soluble form of MP antigen by rationally designing multi‐epitope chimeric antigen (ChA) and screening two classes of protein‐assisting folding element. The study uses a homologous protein antigen as a functional scaffold to generate a ChA possessing four epitopes from transferrin‐binding protein A of Glaesserella parasuis. Our engineered strain, which co‐expresses P17 tagged‐ChA and endogenous chaperones groEL‐ES, yields a 0.346 g/L highly soluble ChA with the property of HPS‐positive serum reaction. Moreover, the protein titer of ChA reaches 4.27 g/L with >90% soluble proportion in 5‐L bioreactor, which is the highest titer reported so far. The results highlight a timely approach to design and improve the soluble expression of MP antigen in industrially viable applications.
Assessment of the botanical origin of Saudi Arabian honey samples to identify pollen with chromatographic tools and packing and storage
Authors: AlNadhari Saleh , Abbasova Gunay , Al‐Qahtani Wahidah H. , Zengin Gokhan , Islamov Sokhib , Mammadova Afat O. , Azad Abul Kalam , Mammadova Shakar , Jaradat Nidal , Babayeva Ulkar , Humbatov Mahmud , Ganbarov Dashgin , Beylerli Ozal , Beilerli Aferin , Toker Ömer Said , Biturku Jonida , Kiren Ifrah 
Published: April 2024

AbstractThe increasing demand for honey purification and authentication necessitates the global utilization of advanced processing tools. Common honey processing techniques, such as chromatography, are commonly used to assess the quality and quantity of valuable honey. In this study, 15 honey samples were authenticated using HPLC and GC–MS chromatographic methods to analyze their pollen spectrum. Various monofloral honey samples were collected, including Acacia, Hypoestes, Lavandula, Tamarix, Trifolium, and Ziziphus species, based on accurate identification by apiarists in 2023 from the Kingdom of Saudi Arabia. Honey analysis revealed the extraction of pollen from 20 different honeybee floral species. Pollen identified from honey samples using advanced chromatographic tools revealed dominant vegetation resources: Ziziphus species (23%), Acacia species (25%), Tamarix species (34%), Lavandula species (26%), Hypoestes species (34%), and Trifolium species (31%). This study uses HPLC to extract phenolic compounds, revealing dominant protocatechuic acid (4.71 mg g−1), and GC–MS to analyze organic compounds in honey pollen. Specifically, 2‐dodecanone was detected with a retention time of 7.34 min. The utilization of chromatographic tools in assessing honey samples for pollen identification provides a reliable and efficient method for determining their botanical origins, thereby contributing to the quality control and authentication of honey products.
A pilot study examining hemomania behaviors in psychiatry outpatients engaged with nonsuicidal self‐injury
Authors: Kandeger Ali , Uygur Omer Faruk , Ataslar Emine Yavuz , Cınar Furkan , Selvi Yavuz 
Published: April 2024

AbstractBackgroundThis study aims to conduct the first‐ever evaluation of our previously proposed behaviors of “hemomania” in individuals engaged with nonsuicidal self‐injury (NSSI).MethodsThe study encompassed 130 outpatients engaged with NSSI who applied at the psychiatry outpatient clinic. NSSI behaviors were assessed using the Inventory of Statements About Self‐Injury, while psychiatric diagnoses were evaluated using the Structured Clinical Interview for DSM‐5 Disorders‐Clinician Version. Subsequently, participants completed the Depression Anxiety Stress Scale‐21 and Short Form of Barratt Impulsiveness Scale.ResultsThe prevalence of at least one hemomania behavior including seeing blood, tasting blood, bloodletting, and blood‐drinking was observed to be 43.1% in individuals with NSSI. When participants were divided into two groups, individuals with hemomania exhibited: (1) a higher incidence of psychiatric comorbidities, increased suicide attempts, and more severe symptoms of depression, anxiety, stress, and impulsivity, (2) higher comorbidity rates of borderline personality disorder, body‐focused repetitive behaviors, and dissociative disorders, and (3) elevated frequencies of certain NSSI behaviors, including cutting, biting, needle‐ticking, and carving, compared to those without.ConclusionHemomania could be considered a specific impulse control disorder, characterized by heightened impulsivity and a persistent urge to obtain one's own blood. However, further studies are needed to validate this hypothesis.
Microalgae Octapeptide IIAVEAGC Alleviates Oxidative Stress and Neurotoxicity in 6‐OHDA‐Induced SH‐SY5Y Cells by Regulating the Nrf2/HO‐1and Jak2/Stat3 Pathways
Authors: Liu Yi , Lin Liyuan , Zheng Haiyan , Huang Huixue , Qian Zhong‐Ji 
Published: April 2024

AbstractNeurodegenerative diseases are characterized by the progressive loss of selectively vulnerable populations of neurons, and many factors are involved in its causes. Neurotoxicity and oxidative stress, are the main related factors. The octapeptide Ile‐Ile‐Ala‐Val‐Glu‐Ala‐Gly‐Cys (IEC) was identified from the microalgae Isochrysis zhanjiangensis and exhibited potential anti‐oxidative stress activity. In this study, the stability of α‐synaptic protein binding to IEC was modeled using molecular dynamics, and the results indicated binding stabilization within 60 ns. Oxidative stress in neurons is the major cause of α‐synaptic protein congestion. Therefore, we next evaluated the protective effects of IEC against oxidative stress and neurotoxicity in 6‐ohdainduced Parkinson's disease (PD) model SH‐SY5Y cells in vitro. In oxidative stress, IEC appeared to increase the expression of the antioxidant enzymes HO‐1 and GPX through the antioxidant pathway of Nrf2, and molecular docking of IEC with Nrf2 and GPX could generate hydrogen bonds. Regarding apoptosis, IEC protected cells by increasing the Bcl‐2/Bax ratio, inhibiting the caspase cascade, acting on p53, and modulating the Jak2/Stat3 pathway. The results indicated that IEC exerted neuroprotective effects through the inhibition of α‐synaptic protein aggregation and antioxidant activity. Therefore, microalgal peptides have promising applications in the prevention and treatment of neurodegenerative diseases.