bluuebunny/crossref_metadata_2025_split huggingface dataset:
How murine neutrophils are hijacked within the microenvironment of pancreatic cancer
Authors: Cassatella Marco Antonio , Scapini Patrizia , Tamassia Nicola 
Published: February 2024

Abstract
Discoveries made in the past decades have brought out that, in addition to their classical primary defensive functions against infections, polymorphonuclear neutrophils play key effector roles not only in chronic inflammatory and immune-mediated diseases but also in cancer. In addition, depending on their differentiation/activation status and/or on the physiological or pathological microenvironment in which they reside, neutrophils have been shown to behave as highly plastic cells, able to acquire new phenotypes/functional states. All these features are well manifested in cancer and modulated during tumor progression. Herein, we discuss intriguing data by Lai Ng's group that have shed light on the origin and development of terminally differentiated, proangiogenic, tumor-associated neutrophils, facilitating tumor growth in a murine orthotopic model of pancreatic ductal adenocarcinoma. These findings help to progress toward the ambitious goal of selectively targeting only the skewed pathological neutrophil populations present within the tumor microenvironment.
CSPP1 stabilizes microtubules by capping both plus and minus ends
Authors: Wang Zhikai , Wang Wenwen , Liu Shuaiyu , Yang Fengrui , Liu Xu , Hua Shasha , Zhu Lijuan , Xu Aoqing , Hill Donald L , Wang Dongmei , Jiang Kai , Lippincott-Schwartz Jennifer , Liu Xing , Yao Xuebiao 
Published: February 2024

Abstract
Although the dynamic instability of microtubules (MTs) is fundamental to many cellular functions, quiescent MTs with unattached free distal ends are commonly present and play important roles in various events to power cellular dynamics. However, how these free MT tips are stabilized remains poorly understood. Here, we report that centrosome and spindle pole protein 1 (CSPP1) caps and stabilizes both plus and minus ends of static MTs. Real-time imaging of laser-ablated MTs in live cells showed deposition of CSPP1 at the newly generated MT ends, whose dynamic instability was concomitantly suppressed. Consistently, MT ends in CSPP1-overexpressing cells were hyper-stabilized, while those in CSPP1-depleted cells were much more dynamic. This CSPP1-elicited stabilization of MTs was demonstrated to be achieved by suppressing intrinsic MT catastrophe and restricting polymerization. Importantly, CSPP1-bound MTs were resistant to mitotic centromere-associated kinesin-mediated depolymerization. These findings delineate a previously uncharacterized CSPP1 activity that integrates MT end capping to orchestrate quiescent MTs.
Percutaneous thrombolysis via cholecystostomy catheter to dissolve biliary clots causing obstructive jaundice
Authors: Smith Sonya A , Simpson Fraser , Bell-Allen Nicholas , Brown Nicholas , Mudaliar Sanjivan , Aftab Khurram , Tam Diana , Chandrasegaram Manju D 
Published: February 2024

Abstract
Haemobilia, or bleeding within the biliary tree, is rare. It can cause biliary obstruction secondary to blood clots. A comorbid 87-year-old was admitted to hospital with acute cholecystitis, choledocholithiasis, and an Escherichia coli bacteremia. He had a partial pancreatectomy and gastrojejunostomy 35 years prior for severe pancreatitis. He was treated with antibiotics and a percutaneous cholecystostomy. He developed atrial fibrillation and was subsequently commenced on warfarin. He re-presented 5 days after discharge with abdominal pain and fevers. Liver function tests revealed cholestasis and a supratherapeutic international normalised ratio. Imaging showed cholecystitis, biliary obstruction, and extensive biliary blood clots. He improved with antibiotics, vitamin K, and alteplase flushes through the percutaneous cholecystostomy. Repeat cholangiogram demonstrated dissolution of the biliary clots. Due to altered anatomy and comorbidities, alteplase flushes were utilized to relieve this patient’s biliary obstruction. Thrombolytics may assist in treating biliary clots when first-line options are not possible or favourable.
First-generation bypass surgery for a giant fusiform aneurysm of the middle cerebral artery: an illustrative case and surgical video
Authors: Bocanegra-Becerra Jhon E , Sánchez José Luis Acha 
Published: February 2024

Abstract
Giant fusiform aneurysms of the middle cerebral artery (MCA) are complex and rare vascular lesions with a poor natural history and challenging treatment decision-making. We report the case of a 46-year-old male with a history of chronic hypertension and a transient ischemic attack who presented with left-sided hemiparesis. A cerebral angiotomography revealed an unruptured giant fusiform aneurysm in the M2 segment of the right MCA. After carefully evaluating the procedure’s risks and benefits with the patient, he underwent a low-flow bypass surgery. An anastomosis between the superficial temporal artery and the M3 segment was performed with proximal clipping of the M2 segment. The postoperative course was uneventful, with preserved bypass patency. At follow-up, the patient was neurologically intact. This report illustrates the nuances and operative techniques for treating a giant fusiform aneurysm of the M2 segment that accounted for a preserved bypass patency and optimal patient neurological recovery.
Feeding on lactic acid bacteria isolated from food extends the lifespan of Caenorhabditis elegans
Authors: Komura Tomomi , Aoki Motoshi , Nishikawa Yoshikazu 
Published: February 2024

Abstract
Lactic acid bacteria (LAB) contribute to human health, and LAB functionality has been studied using Caenorhabditis elegans as an alternative host. However, many studies have focused on the efficacy of a single strain of LAB, and few reports have compared various LAB strains. In this study, we examined the effects of 15 strains of LAB isolated from vegetables, meat, and fermented foods on nematode longevity and healthy lifespan. To reduce the frequency of laborious survival observations, we performed a lifespan assay on agar plates containing 2′-deoxy-5-fluorouridine (FUdR), which inhibits egg hatching and prevents generation mixing. Four beneficial strains showed significant lifespan extension and increased spontaneous nematode mobility, regardless of treatment with or without FUdR and the frequency of survival observation. These results suggested increased longevity and an extended healthy lifespan, confirming the reliability of our method. The four strains are expected to show anti-ageing effects besides longevity and have effects on age-related degenerative diseases. Our labor-saving method can be used as an alternative to conventional methods and enable simultaneous screening of multiple strains. Future research could explore factors contributing to lifespan regulation by comparing and verifying differential strain effects on lifespan.
A Pilot Study Using a Standardized Trauma Assessment Tool After Tactical Combat Casualty Care Course: A Comparison of the United States and Ghana
Authors: Polley Catherine C , Adu-Gyamfi Rossi , Mahama-Toure Tawfik , Okpoti Konney Fattal , Oti-Boateng Emmanuel , Nsohlebna Nsoh Lawrence , Ballard Timothy 
Published: February 2024

ABSTRACT

Introduction
Assessment, monitoring, and evaluation have been a required part of Global Health Engagement but difficult to accomplish. The current assessment, monitoring, and evaluation frameworks require implementation at the start of the project and are not designed to use for already existing programs. Tactical Combat Casualty Care (TCCC) is a standardized course now offered in 89 countries, but there has not been a standardized method of evaluating the quality across programs. Ghana’s TCCC program began in March 2022 and provides a platform for development of a new method of evaluation globally.

Methods
In this study, a standardized trauma scenario was performed by two groups of students, one who completed a TCCC Medical Provider course in Fort Detrick, MD and one who completed the course in Accra, Ghana. The students were scored using a standardized Trauma Assessment Score Sheet and the scores compared across the two groups.

Results
The mean Trauma Assessment Score was 58.5% in the United States and 58.3% in Ghana, with no statistically significant difference between the two groups (P-value of .97). When regressed for confounding variables such as years of experience and deployment, the two groups still had no statistically significant difference (P-value of .783).

Discussion
The two groups achieved similar mean scores despite significantly different testing environments and experience levels. Written post-test scores did not correlate well due to multiple confounding factors and appear to be a less accurate representation of student understanding and application than the Trauma Assessment Score.

Conclusion
This study demonstrates use of a standardized scenario with graded checklist to compare between international programs. This can be used to and expanded to compare programs and support quality assurance and medical interoperability.
A Baseline Model of PTSD From the ACES Cohort
Authors: Millington Donna J , Blackburn August N , Herrera Dianna , Dalgard Clifton L , Willis Adam M 
Published: February 2024

ABSTRACT

Introduction
Post-traumatic stress disorder (PTSD) is a primary military psychiatric condition with complex etiology including strong genetic and/or environmental influences. Environmental influences and demographics can play a role in supporting underlying genetic traits for clinical utility evaluation as risk modifying factors. We are undertaking an IRB approved study to evaluate polygenic scores of PTSD risk in the adverse childhood experience and serotonin (ACES) transporter cohort.

Materials and Methods
Baseline demographic characteristics and statistical modeling of 291 active duty service members from ACES cohort were used and excluded individuals with traumatic brain injury-induced loss of consciousness, pre-deployment PTSD or anxiety disorder, and pre-deployment prescription of antidepressants or psychoactive medications. Summary of categorical and numerical variables were evaluated using chi-square and t-test, respectively. We model PTSD risk and associated scores using linear and logistic regressions.

Results
The ACES subset was 79.1% males, multi-ancestry, and mean age of 38.3 years. Most PTSD individuals received behavioral therapy (89.6%) and/or prescribed antidepressants (67%) had higher scores in ACES, combat exposure scales, PTSD checklist military version, neurobehavioral symptom inventory, Pittsburg sleep quality index, insomnia severity index, and composite autonomic symptom score surveys and were less likely to expect future deployment. A positive correlation between age, total months deployed, ACES, CES, PCL-M, and positive-PTSD diagnosis were consistent but not in older individuals, who were more likely and frequently deployed although increasing risk for combat exposure.

Conclusion
Demographic characteristics of the ACES cohort fit a coherent model of risk for PTSD to evaluate polygenic scores. Additional research is merited to understand PTSD effects on these confounding factors.
Molecular epidemiology of Candida africana isolates collected from vagina swabs in French Guiana
Authors: Bigot Jeanne , Kalboussi Yasmine , Bonkoto Nkoy Yannick , Benmostefa Alexis , Vellaissamy Sandra , Benzerara Laurent , Sainte-Rose Vincent , Blanchet Denis , Demar Magalie , Guitard Juliette , Hennequin Christophe 
Published: February 2024

Abstract
Previous molecular studies have shown that Candida africana corresponds to the clade 13 of Candia albicans. It has been mostly involved in vulvovaginal candidiasis worldwide but few data exist in South America. The aim of our study was to investigate the prevalence of C. africana in women living in French Guiana. For this, we first set up a fluorescent-intercalating-dye-real time Polymerase Chain Reaction (PCR) targeting the hyphal wall protein 1 gene. The test was applied to 212 C. albicans isolates collected from May to August 2019 from vaginal swabs, allowing the identification of six women harboring C. africana (eight isolates). The in vitro susceptibility of these eight isolates to six antifungal drugs was also evaluated. No demographics or clinical-specific features could be demonstrated. Genetic diversity of those isolates was analyzed through multilocus sequence typing and showed that diploid sequence type 182 was predominant (n = 6) and allowed the report of a new diploid sequence type.
The NOEMA observations of GN-z11: constraining the neutral interstellar medium and dust formation in the heart of cosmic reionization at z = 10.6
Authors: Fudamoto Y , Oesch P A , Walter F , Decarli R , Carilli C L , Ferrara A , Barrufet L , Bouwens R , Dessauges-Zavadsky M , Nelson E J , Dannerbauer H , Illingworth G , Inoue A K , Marques-Chaves R , Pérez-Fournon I , Riechers D A , Schaerer D , Smit R , Sugahara Y , van der Werf P 
Published: February 2024

ABSTRACT
We present results of dust continuum and [C ii]$\, 158\, {\rm \mu m}$ emission line observations of a remarkably UV luminous (MUV = −21.6) galaxy at z = 10.603: GN-z11. Using the Northern Extended Millimeter Array (NOEMA), observations have been carried out over multiple observing cycles. We achieved a high sensitivity resulting in a $\lambda _{\rm rest}=160\, {\rm \mu m}$ continuum $1\, \sigma$ sensitivity of $13.0\, \rm {\mu Jy \, beam}^{ -1}$ and a [C ii] emission line $1\, \sigma$ sensitivity of $31\, \rm {mJy\, beam^{ -1}\, km \, s}^{ -1}$ using $50\, \rm {km \, s}^{ -1}$ binning with a $\sim 2\, {\rm arcsec}$ synthesized beam. Neither dust continuum nor [C ii]$\, 158\, {\rm \mu m}$ line emission are detected at the expected frequency of ν[C ii]$= 163.791\, \rm {GHz}$ and the sky location of GN-z11. The upper limits show that GN-z11 is neither luminous in LIR nor L[C ii], with a dust mass $3\, \sigma$ limit of ${\rm log}\, (M_{\rm dust}/{\rm {\rm M}_{\odot }}) \, \lt\, 6.5-6.9$ and with a [C ii] based molecular gas mass $3\, \sigma$ limit of log (Mmol, [C ii]$/{\rm {\rm M}_{\odot }}) \, \lt \, 9.3$. Together with radiative transfer calculations, we also investigated the possible cause of the dust poor nature of the GN-z11 showed by the blue colour in the UV continuum of GN-z11 (βUV = −2.4), and found that ≳3 × deeper observations are crucial to study dust production at very high-redshift. Nevertheless, our observations show the crucial role of deep mm/submm observations of very high-redshift galaxies to constrain multiple phases in the interstellar medium.
Hints of a disrupted binary dwarf galaxy in the Sagittarius stream
Authors: Davies Elliot Y , Monty Stephanie , Belokurov Vasily , Dillamore Adam M 
Published: February 2024

ABSTRACT
In this work, we look for evidence of a non-unity mass ratio binary dwarf galaxy merger in the Sagittarius stream. Simulations of such a merger show that, upon merging with a host, particles from the less massive galaxy will often mostly be found in the extended stream and less so in the central remnant. Motivated by these simulations, we use the Apache Point Observatory Galactic Evolution Experiment Data Release 17 chemical data from approximately 1100 stars in both the Sagittarius remnant and stream to look for evidence of contamination from a second dwarf galaxy. We separate the Sagittarius data into its remnant and stream and compare the [Mg/Fe] content of the two populations. In particular, we select [Mg/Fe] to search for hints of unique star formation histories among our sample stars. Comparing the stream and remnant populations, we find regions that have distinct [Mg/Fe] distributions for fixed [Fe/H], in addition to distinct chemical tracks in [Mg/Fe]–[Fe/H] abundance space. We show that there are large regions of the tracks for which the probability of the two samples being drawn from the same distribution is very low (p &lt; 0.05). Furthermore, we show that the two tracks can be fit with unique star formation histories using simple, one-zone galactic chemical evolution models. While more work must be done to discern whether the hypothesis presented here is true, our work hints at the possibility that Sagittarius may consist of two dwarf galaxy progenitors.
Nucleosynthesis in magnetorotational supernovae: impact of the magnetic field configuration
Authors: Reichert Moritz , Bugli Matteo , Guilet Jérôme , Obergaulinger Martin , Aloy Miguel Ángel , Arcones Almudena 
Published: February 2024

ABSTRACT
The production of heavy elements is one of the main by-products of the explosive end of massive stars. A long sought goal is finding differentiated patterns in the nucleosynthesis yields, which could permit identifying a number of properties of the explosive core. Among them, the traces of the magnetic field topology are particularly important for extreme supernova (SN) explosions, most likely hosted by magnetorotational effects. We investigate the nucleosynthesis of five state-of-the-art magnetohydrodynamic models with fast rotation that have been previously calculated in full 3D and that involve an accurate neutrino transport (M1). One of the models does not contain any magnetic field and synthesizes elements around the iron group, in agreement with other CC-SNe models in literature. All other models host a strong magnetic field of the same intensity, but with different topology. For the first time, we investigate the nucleosynthesis of MR-SNe models with a quadrupolar magnetic field and a 90° tilted dipole. We obtain a large variety of ejecta compositions reaching from iron nuclei to nuclei up to the third r-process peak. We assess the robustness of our results by considering the impact of different nuclear physics uncertainties such as different nuclear masses, β−-decays and β−-delayed neutron emission probabilities, neutrino reactions, fission, and a feedback of nuclear energy on the temperature. We find that the qualitative results do not change with different nuclear physics input. The properties of the explosion dynamics and the magnetic field configuration are the dominant factors determining the ejecta composition.
Under the light of a new star: evolution of planetary atmospheres through protoplanetary disc dispersal and boil-off
Authors: Rogers James G , Owen James E , Schlichting Hilke E 
Published: February 2024

ABSTRACT
The atmospheres of small, close-in exoplanets are vulnerable to rapid mass loss during protoplanetary disc dispersal via a process referred to as ‘boil-off’, in which confining pressure from the local gas disc reduces, inducing atmospheric loss and contraction. We construct self-consistent models of planet evolution during gaseous core accretion and boil-off. As the surrounding disc gas dissipates, we find that planets lose mass via subsonic breeze outflows which allow causal contact to exist between disc and planet. Planets initially accrete of order $\sim 10~{{\ \rm per\ cent}}$ in atmospheric mass, however, boil-off can remove $\gtrsim 90~{{\ \rm per\ cent}}$ of this mass during disc dispersal. We show that a planet’s final atmospheric mass fraction is strongly dictated by the ratio of cooling time-scale to disc dispersal time-scale, as well as the planet’s core mass and equilibrium temperature. With contributions from core cooling and radioactivity, we show that core luminosity eventually leads to the transition from boil-off to core-powered mass loss. We find that smaller mass planets closest to their host star may have their atmospheres completely stripped through a combination of boil-off and core-powered mass loss during disc dispersal, implying the existence of a population-level radius gap emerging as the disc disperses. We additionally consider the transition from boil-off/core-powered mass loss to X-ray and extreme ultraviolet (XUV) photoevaporation by considering the penetration of stellar XUV photons below the planet’s sonic surface. Finally, we show that planets may open gaps in their protoplanetary discs during the late stages of boil-off, which may enhance mass-loss rates.
Chemical abundances and ionizing mechanisms in the star-forming double-ring of AM 0644-741 using MUSE data
Authors: Gómez-González V M A , Mayya Y D , Zaragoza-Cardiel J , Bruzual G , Charlot S , Ramos-Larios G , Oskinova L M , Sander A A C , Serantes S Reyero 
Published: February 2024

ABSTRACT
We present the analysis of archival Very Large Telescope Multi-Unit Spectroscopic Explorer observations of 179 H ii regions in the star-forming double-ring collisional galaxy AM 0644-741 at 98.6 Mpc. We determined ionic abundances of He, N, O, and Fe using the direct method for the brightest H ii region (ID 39); we report $\log \rm {(\frac{N}{O})}=-1.3\pm 0.2$ and $12+\log \rm {(\frac{O}{H})}=8.9\pm 0.2$. We also find the so-called ‘blue-bump’, broad He ii λ4686, in the spectrum of this knot of massive star formation; its luminosity being consistent with the presence of ∼430 Wolf–Rayet (WR) stars of the nitrogen late-type. We determined the O abundances for 137 H ii regions using the strong-line method; we report a median value of $12+\log \rm {(\frac{O}{H})}=8.5\pm 0.8$. The location of three objects, including the WR complex, coincide with that of an Ultra Luminous X-ray source. Nebular He ii is not detected in any H ii region. We investigate the physical mechanisms responsible for the observed spectral lines using appropriate diagnostic diagrams and ionization models. We find that the H ii regions are being photoionized by star clusters with ages ∼2.5–20 Myr and ionization potential −3.5 &lt;log 〈U〉&lt;−3.0. In these diagrams, a binary population is needed to reproduce the observables considered in this work.
Broad-band spectral and temporal study of Ton 599 during the brightest 2023 January flare
Authors: Manzoor Aaqib , Shah Zahir , Sahayanathan Sunder , Iqbal Naseer , Dar Athar A 
Published: February 2024

ABSTRACT
In this work, we provide a detailed analysis of the broad-band temporal and spectral properties of the blazar Ton 599 by using observations from the Fermi Large Area Telescope (LAT) and Swift X-Ray Telescope (XRT)/Ultraviolet–Optical Telescope (UVOT), during its brightest γ-ray flaring. The one-day bin γ-ray light curve exhibits multiple substructures with asymmetric and symmetric profiles. Notably, the γ-ray light curve shows a maximum flux of $\rm 3.63 \times 10^{-6}\, photon\, cm^{-2}\, s^{-1}$ on MJD 59954.50, which is the highest flux ever observed from this source. The correlation between the γ-ray flux and γ-ray spectral indices suggests a moderate ‘harder when brighter’ trend. Taking the γ-ray light curve as the reference, a strong correlation is observed with X-ray, optical, and UV energies. Additionally, the γ-rays and optical/UV emission exhibit higher variability compared with X-rays. To understand the parameter variation during the active state of the source, we conducted a statistical broad-band spectral modelling of the source in 10 flux intervals of equal duration. A one-zone leptonic model involving synchrotron, synchrotron-self-Compton, and external Compton processes successfully reproduces the broad-band spectral energy distribution (SED) in each of these flux intervals. We observed that flux variation during the active state is associated mainly with variation in the magnetic field and particle spectral indices.