bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of antipsychotic medication, benzodiazepines, and psychiatric hospitalization in cannabis-related versus cannabis-unrelated schizophrenia – a nationwide, register-based cohort study
Authors: Hjorthøj Carsten , Stürup Anne , Karlsen Mette , Speyer Helene , Osler Merete , Ongur Dost , Nordentoft Merete 
Published: April 2024

AbstractBackgroundEvidence suggests that cannabis may be a causal factor for development of schizophrenia. We aimed to investigate whether use of antipsychotic medication, benzodiazepines, and psychiatric service use differs among patients with schizophrenia depending on whether psychosis was precipitated by a diagnosis of cannabis use disorder (CUD).MethodsWe utilized the nationwide Danish registries to identify all individuals with an incident diagnosis of schizophrenia from 1995 to 2016. We also collected information on whether first CUD diagnosis preceded schizophrenia and thus defined a group of potentially cannabis-related schizophrenia. We compared the cannabis-related schizophrenia group both with all non-cannabis-related patients with schizophrenia and with non-cannabis-related patients with schizophrenia that were propensity-score matched to cases using a range of potentially confounding variables.ResultsWe included 35 714 people with incident schizophrenia, including 4116 (11.5%) that were cannabis-related. In the unmatched-comparison analyses, there were no clear differences over time in use of antipsychotics and benzodiazepines related to whether the diagnosis of schizophrenia was cannabis-related. After propensity-score matching, use of antipsychotics and benzodiazepines was significantly lower among cannabis-related cases of schizophrenia. In the unmatched comparison, the cannabis-related group had significantly more days admitted than the non-cannabis-related group. This was markedly attenuated after propensity-score matching.ConclusionsOur findings indicate the importance of considering cannabis-related cases of schizophrenia as a potentially distinct disorder in terms of prognosis. It is unclear, however, if these differences are due to different biological types of schizophrenia being compared or if they rather indicate behavioral differences such as reduced adherence and treatment-seeking.
Pollen movement of the endemic Agave cupreata by bats and birds in western Mexico
Authors: Arreola-Gómez Rosario , Mendoza Eduardo 
Published: April 2024

Abstract
We quantified the amount of pollen carried by bats and birds visiting the flowers of cultivated and wild individuals of the endemic Agave cupreata in western Mexico and estimated the distance to which pollen was moved using diurnal/nocturnal inflorescence exclusions and fluorescent powders. There were no differences in the amount of pollen transported by bats and birds near cultivated and wild agaves, but overall, bats transported greater loads than birds. Nocturnal pollen movement was more frequent, and the maximum distance recorded was 630 m (diurnal and nocturnal), with no transfer between cultivated and wild plants. Bats seem to provide a greater pollination service than birds in our focal anthropized landscape. It is necessary to incorporate management practices into mezcal production that ensure enough food for the wide array of animal species using this resource, which in turn will help to maintain the pollination service.
Low juvenile survival threatens the Black Stork Ciconia nigra in northern Europe
Authors: Väli Ülo , Strazds Māris , Kaldma Katrin , Treinys Rimgaudas 
Published: April 2024

Summary
Detecting factors causing the decline of wildlife populations provides essential knowledge for their effective conservation. Populations of Black Stork Ciconia nigra are decreasing in northern Europe; however, there are no detailed analyses of its survival, which frequently is a key demographic parameter affecting population dynamics in long-lived species. We used long-term data from re-sighted colour-ringed birds and satellite-tracked birds to estimate age- and sex-specific survival in a rapidly declining Black Stork population in the Baltic region at the northern end of the European range. Apparent survival (0.89) among colour-ringed birds older than one year was not significantly different from the previously reported estimates in Central Europe and the estimated real survival of GPS-tracked birds (0.77). However, the apparent survival of first-year (1y) birds was only 0.04, which is remarkably lower than earlier estimates in Central Europe. The real survival of GPS-tracked 1y birds was somewhat higher (0.11), but still much lower than estimates in other long-lived species. Apparent survival was three times lower in 1y females (0.013) than 1y males (0.045); this could be explained in part by a higher mean natal dispersal of females (189.1 km), compared with that of males (72.0 km), as well as by sex-specific mortality due to poor foraging conditions. There were no significant differences in apparent survival between the male and female storks older than one year. To better address the population decline, further research is needed to determine the factors causing low survival in young Black Storks, including the roles of food availability and climate change.
Opera and Land: Settler Colonialism and the Geopolitics of Music at the Carlisle Indian Industrial School
Authors: Baron Derek 
Published: April 2024

AbstractThis article examines the politics of music at the Carlisle Indian Industrial School, the flagship federal off-reservation boarding school for the compulsory education of Indigenous children, established in Carlisle, Pennsylvania, in 1879. By examining the music education and performance culture at the Carlisle School, this article considers the role of music both within boarding school discourses of “civilization” and in terms of the larger federal goal of dispossession of Native land. Based on original archival research and engagements with contemporary discourses in Indigenous music and sound studies, the article then considers a nationalistic comic opera titled The Captain of Plymouth performed by Native students at the Carlisle commencement exercises in 1909. It argues ultimately that, although music, dance, and expressive culture were a central concern for federal assimilationist policy, music making at Carlisle provided a groundwork for the emergence of an intertribal social formation that guided musical practices and self-determination movements of the twentieth and twenty-first centuries.
Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Authors: Ramos-Prats Arnau , Matulewicz Pawel , Edenhofer Marie-Luise , Wang Kai-Yi , Yeh Chia-Wei , Fajardo-Serrano Ana , Kress Michaela , Kummer Kai , Lien Cheng-Chang , Ferraguti Francesco 
Published: April 2024

AbstractSubtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu5 act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu5 has been proposed to contribute to the exacerbation of neuropsychiatric disorders. Here, we examined how these receptors regulate the activity of somatostatin-expressing (SST+) neurons, as well as their influence on behavior and brain rhythmic activity. Loss of mGlu5 in SST+ neurons elicited excitatory synaptic dysfunction in a region and sex-specific manner together with a range of emotional imbalances including diminished social novelty preference, reduced anxiety-like behavior and decreased freezing during retrieval of fear memories. In addition, the absence of mGlu5 in SST+ neurons during fear processing impaired theta frequency oscillatory activity in the medial prefrontal cortex and ventral hippocampus. These findings reveal a critical role of mGlu5 in controlling SST+ neurons excitability necessary for regulating negative emotional states.
GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
Authors: Han Yang , Zhao Hongling , Li Gang , Jia Jin , Guo Hejiang , Tan Jinpeng , Sun Xingyao , Li Saiyu , Ran Qian , Bai Chenjun , Gu Yongqing , Li ZhongJun , Guan Hua , Gao Shanshan , Zhou Ping-Kun 
Published: April 2024

Abstract
Background
DNA double-strand break (DSB) induction and repair are important events for determining cell survival and the outcome of cancer radiotherapy. The DNA-dependent protein kinase (DNA-PK) complex functions at the apex of DSBs repair, and its assembly and activity are strictly regulated by post-translation modifications (PTMs)-associated interactions. However, the PTMs of the catalytic subunit DNA-PKcs and how they affect DNA-PKcs’s functions are not fully understood.

Methods
Mass spectrometry analyses were performed to identify the crotonylation sites of DNA-PKcs in response to γ-ray irradiation. Co-immunoprecipitation (Co-IP), western blotting, in vitro crotonylation assays, laser microirradiation assays, in vitro DNA binding assays, in vitro DNA-PK assembly assays and IF assays were employed to confirm the crotonylation, identify the crotonylase and decrotonylase, and elucidate how crotonylation regulates the activity and function of DNA-PKcs. Subcutaneous xenografts of human HeLa GCN5 WT or HeLa GCN5 siRNA cells in BALB/c nude mice were generated and utilized to assess tumor proliferation in vivo after radiotherapy.

Results
Here, we reveal that K525 is an important site of DNA-PKcs for crotonylation, and whose level is sharply increased by irradiation. The histone acetyltransferase GCN5 functions as the crotonylase for K525-Kcr, while HDAC3 serves as its dedicated decrotonylase. K525 crotonylation enhances DNA binding activity of DNA-PKcs, and facilitates assembly of the DNA-PK complex. Furthermore, GCN5-mediated K525 crotonylation is indispensable for DNA-PKcs autophosphorylation and the repair of double-strand breaks in the NHEJ pathway. GCN5 suppression significantly sensitizes xenograft tumors of mice to radiotherapy.

Conclusions
Our study defines K525 crotonylation of DNA-PKcs is important for the DNA-PK complex assembly and DSBs repair activity via NHEJ pathway. Targeting GCN5-mediated K525 Kcr of DNA-PKcs may be a promising therapeutic strategy for improving the outcome of cancer radiotherapy.
The formation of unsaturated IrOx in SrIrO3 by cobalt-doping for acidic oxygen evolution reaction
Authors: Zhao Jia-Wei , Yue Kaihang , Zhang Hong , Wei Shu-Yin , Zhu Jiawei , Wang Dongdong , Chen Junze , Fominski Vyacheslav Yu. , Li Gao-Ren 
Published: April 2024

AbstractElectrocatalytic water splitting is a promising route for sustainable hydrogen production. However, the high overpotential of the anodic oxygen evolution reaction poses significant challenge. SrIrO3-based perovskite-type catalysts have shown great potential for acidic oxygen evolution reaction, but the origins of their high activity are still unclear. Herein, we develop a Co-doped SrIrO3 system to enhance oxygen evolution reaction activity and elucidate the origin of catalytic activity. In situ experiments reveal Co activates surface lattice oxygen, rapidly exposing IrOx active sites, while bulk Co doping optimizes the adsorbate binding energy of IrOx. The Co-doped SrIrO3 demonstrates high oxygen evolution reaction electrocatalytic activity, markedly surpassing the commercial IrO2 catalysts in both conventional electrolyzer and proton exchange membrane water electrolyzer.
Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation
Authors: Lee Gil-Woo , Kim Young Ju , Lee Sung-Woo , Kim Hee-Ok , Kim Daeun , Kim Jiyoung , Kim You-Me , Kang Keunsoo , Rhee Joon Haeng , Chung Ik Joo , Bae Woo Kyun , Oh In-Jae , Yang Deok Hwan , Cho Jae-Ho 
Published: April 2024

AbstractThe differentiation of naive CD8+ T cells into effector cells is important for establishing immunity. However, the effect of heterogeneous naive CD8+ T cell populations is not fully understood. Here, we demonstrate that steady-state naive CD8+ T cells are composed of functionally heterogeneous subpopulations that differ in their ability to differentiate into type 17 cytotoxic effector cells (Tc17) in a context of murine inflammatory disease models, such as inflammatory bowel disease and graft-versus-host disease. The differential ability of Tc17 differentiation is not related to T-cell receptor (TCR) diversity and antigen specificity but is inversely correlated with self-reactivity acquired during development. Mechanistically, this phenomenon is linked to differential levels of intrinsic TCR sensitivity and basal Suppressor of Mothers Against Decapentaplegic 3 (SMAD3) expression, generating a wide spectrum of Tc17 differentiation potential within naive CD8+ T cell populations. These findings suggest that developmental self-reactivity can determine the fate of naive CD8+ T cells to generate functionally distinct effector populations and achieve immense diversity and complexity in antigen-specific T-cell immune responses.
Observation of Kekulé vortices around hydrogen adatoms in graphene
Authors: Guan Yifei , Dutreix Clement , González-Herrero Héctor , Ugeda Miguel M. , Brihuega Ivan , Katsnelson Mikhail I. , Yazyev Oleg V. , Renard Vincent T. 
Published: April 2024

AbstractFractional charges are one of the wonders of the fractional quantum Hall effect. Such objects are also anticipated in two-dimensional hexagonal lattices under time reversal symmetry—emerging as bound states of a rotating bond texture called a Kekulé vortex. However, the physical mechanisms inducing such topological defects remain elusive, preventing experimental realization. Here, we report the observation of Kekulé vortices in the local density of states of graphene under time reversal symmetry. The vortices result from intervalley scattering on chemisorbed hydrogen adatoms. We uncover that their 2π winding is reminiscent of the Berry phase π of the massless Dirac electrons. We can also induce a Kekulé pattern without vortices by creating point scatterers such as divacancies, which break different point symmetries. Our local-probe study thus confirms point defects as versatile building blocks for Kekulé engineering of graphene’s electronic structure.
Diffusion-rate sieving of propylene and propane mixtures in a cooperatively dynamic porous crystal
Authors: Su Yan , Otake Ken-ichi , Zheng Jia-Jia , Wang Ping , Lin Qing , Kitagawa Susumu , Gu Cheng 
Published: April 2024

AbstractSelective molecular recognition is an important alternative to the energy-intensive industrial separation process. Porous coordination polymers (PCPs) offer designing platforms for gas separation because they possess precise controllability over structures at the molecular level. However, PCPs-based gas separations are dominantly achieved using strong adsorptive sites for thermodynamic recognition or pore-aperture control for size sieving, which suffer from insufficient selectivity or sluggish kinetics. Developing PCPs that work at high temperatures and feature both high uptake capacity and selectivity is urgently required but remains challenging. Herein, we report diffusion-rate sieving of propylene/propane (C3H6/C3H8) at 300 K by constructing a PCP material whose global and local dynamics cooperatively govern the adsorption process via the mechanisms of the gate opening for C3H6 and the diffusion regulation for C3H8, respectively, yielding substantial differences in both uptake capacity and adsorption kinetics. Dynamic separation of an equimolar C3H6/C3H8 mixture reveals outstanding sieving performance with a C3H6 purity of 99.7% and a separation factor of 318.
Two orthogonal differentiation gradients locally coordinate fruit morphogenesis
Authors: Gómez-Felipe Andrea , Branchini Elvis , Wang Binghan , Marconi Marco , Bertrand-Rakusová Hana , Stan Teodora , Burkiewicz Jérôme , de Folter Stefan , Routier-Kierzkowska Anne-Lise , Wabnik Krzysztof , Kierzkowski Daniel 
Published: April 2024

AbstractMorphogenesis requires the coordination of cellular behaviors along developmental axes. In plants, gradients of growth and differentiation are typically established along a single longitudinal primordium axis to control global organ shape. Yet, it remains unclear how these gradients are locally adjusted to regulate the formation of complex organs that consist of diverse tissue types. Here we combine quantitative live imaging at cellular resolution with genetics, and chemical treatments to understand the formation of Arabidopsis thaliana female reproductive organ (gynoecium). We show that, contrary to other aerial organs, gynoecium shape is determined by two orthogonal, time-shifted differentiation gradients. An early mediolateral gradient controls valve morphogenesis while a late, longitudinal gradient regulates style differentiation. Local, tissue-dependent action of these gradients serves to fine-tune the common developmental program governing organ morphogenesis to ensure the specialized function of the gynoecium.
Research on the effect of different aerobic activity on physical fitness and executive function in primary school students
Authors: Ren Yue , Chu Jun , Zhang Zhongyuan , Luo Bingquan 
Published: April 2024

AbstractTo evaluate the effect of 16 weeks of different aerobic activity on physical fitness and executive functions in primary school students. 90 right-handed students from China (Boys = 46; Girls = 44) participated in our study and were randomly separated into four groups: 20 in the control group (Con), 23 in the physical activity group (PA), 25 in the intellectual activity group (IA), 22 in the physical activity and intellectual activity group (PA + IA). The students in PA, IA and PA + IA group received aerobic exercise program lasted 40 min daily, 4 days a week for 16 weeks, regular physical activity in the PA group, intellectual activity in the IA group, physical activity couple with intellectual activity in the PA + IA group, respectively. All the students participate the experiment for body composition, physical fitness (cardiopulmonary fitness, muscle strength, speed sensitivity, flexibility quality), executive functions and saliva analysis test before and after 16 weeks. There was no significant effect of 16 weeks different aerobic exercise interventions on body composition before and after exercise interventions among four groups in children (p > 0.05). The results were obtained by inter-group and intra-group comparisons that different exercise interventions (physical activity, intellectual activity, physical combine with intellectual activity), all can significantly improve physical fitness parameters (cardiopulmonary fitness, muscle strength, speed sensitivity and flexibility quality), and executive functions parameters (inhibitory control, working memory, reaction time cognitive flexibility), as well as the concentration of saliva GH and IGF-I (p < 0.05) in children. Our experiment further demonstrated that the improvement effect of the two exercises together is more significant than that of the single exercise ways. Both physical and intellectual activity can effectively improve physical fitness and executive function in children, and the improvement effect of the two exercises together is more significant than that of the single exercise ways.
Reduced Tolerance for Risky Play in Primary Caregivers of Children With Hearing Loss
Authors: Deniz Burcu , Kara Halide Çetin , Çögen Talha 
Published: April 2024

Purpose:
It is known that taking appropriate risks during play is crucial for the development of a child's creativity, problem-solving abilities, resilience, self-confidence, and skills in evaluating risky situations. However, communication problems resulting from hearing loss (HL) can affect a child's ability to hear danger and warning signals during play, potentially leading to injury. This study investigates the attitudes of parents or caregivers with children with HL toward risky play.

Method:

The study included 170 caregivers of children with normal hearing (NH;
n
= 103) and cochlear implant and/or hearing aids users (
n
= 67) aged 3–13 years. The primary caregiver completed the Tolerance for Risk in Play Scale (TRIPS), and the caregivers of children with HL also completed the Auditory Behavior in Everyday Life (ABEL) questionnaire.

Results:

TRIPS total scores were significantly higher in the NH group (
p
< .05). Mothers of children with HL had lower TRIPS scores than mothers of children with NH (
p
< .05). Similarly, lower TRIPS scores were found in the lower income group with HL (
p
< .05). A weak positive correlation was observed between TRIPS and both the ABEL total score (
p
< .05,
r
= .207) and ABEL auditory awareness score (
p
< .05,
r
= .204) in the hard of hearing group.

Conclusions:
The study found that caregivers of children with HL have less tolerance for risky play. Additionally, caregivers of children with better auditory skills were more tolerant of risky play. Therefore, it is suggested that caregivers of children using appropriate hearing devices should be informed that they do not need to be overly restrictive during play, and these children should be encouraged to engage in risky play.
Written Language Practice, Self-Efficacy, and Beliefs: A Survey of Speech-Language Pathologists Working With School-Aged Clients
Authors: Yi Julia J. , Erickson Karen A. 
Published: April 2024

Purpose:
This study examined the clinical practice, self-efficacy, and beliefs about assessing and treating written language among speech-language pathologists (SLPs) working with school-aged clients (aged 5–21 years) in school and nonschool settings in the United States.

Method:
A survey was completed by a nationwide sample of 344 SLPs working with school-aged clients in the United States. Statistical analyses were conducted to determine differences between (a) SLPs' self-efficacy in assessing and treating spoken versus written language and (b) school-based and non–school-based SLPs' clinical practice, self-efficacy, and beliefs about their roles with written language.

Results:
All respondents reported significantly lower rates of self-efficacy in assessing and treating written language compared to spoken language, and their self-efficacy had a significant, positive relationship with the amount of clinical time devoted to written language. School-based SLPs devoted a significantly lower percentage of clinical time to written language, had significantly lower self-efficacy in addressing written language, and had lower rates of agreement on statements about their roles and responsibilities with written language compared to non–school-based SLPs. These differences were not found with spoken language. The most prevalent written language needs on respondents' workloads were reported as written expression (69.3%) and reading comprehension (66%).

Conclusions:
School-based and non–school-based SLPs report different levels of clinical time devoted to written language, self-efficacy in addressing written language, and beliefs about their roles in addressing written language. There is a need to investigate the reasons for these differences and the potential impact of preservice and in-service training in ameliorating them.

Supplemental Material:

https://doi.org/10.23641/asha.25511047