bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary sodium acetate and sodium butyrate improve high-carbohydrate diet utilization by regulating gut microbiota, liver lipid metabolism, oxidative stress, and inflammation in largemouth bass (Micropterus salmoides)
Authors: Liu Qiao , Cheng Liangshun , Wang Maozhu , Shen Lianfeng , Zhang Chengxian , Mu Jin , Hu Yifan , Yang Yihui , He Kuo , Yan Haoxiao , Zhao Liulan , Yang Song 
Published: April 2024

Abstract
Background
Adequate level of carbohydrates in aquafeeds help to conserve protein and reduce cost. However, studies have indicated that high-carbohydrate (HC) diet disrupt the homeostasis of the gut–liver axis in largemouth bass, resulting in decreased intestinal acetate and butyrate level.

Method
Herein, we had concepted a set of feeding experiment to assess the effects of dietary sodium acetate (SA) and sodium butyrate (SB) on liver health and the intestinal microbiota in largemouth bass fed an HC diet. The experimental design comprised 5 isonitrogenous and isolipidic diets, including LC (9% starch), HC (18% starch), HCSA (18% starch; 2 g/kg SA), HCSB (18% starch; 2 g/kg SB), and HCSASB (18% starch; 1 g/kg SA + 1 g/kg SB). Juvenile largemouth bass with an initial body weight of 7.00 ± 0.20 g were fed on these diets for 56 d.

Results
We found that dietary SA and SB reduced hepatic triglyceride accumulation by activating autophagy (ATG101, LC3B and TFEB), promoting lipolysis (CPT1α, HSL and AMPKα), and inhibiting adipogenesis (FAS, ACCA, SCD1 and PPARγ). In addition, SA and SB decreased oxidative stress in the liver (CAT, GPX1α and SOD1) by activating the Keap1-Nrf2 pathway. Meanwhile, SA and SB alleviated HC-induced inflammation by downregulating the expression of pro-inflammatory factors (IL-1β, COX2 and Hepcidin1) through the NF-κB pathway. Importantly, SA and SB increased the abundance of bacteria that produced acetic acid and butyrate (Clostridium_sensu_stricto_1). Combined with the KEGG analysis, the results showed that SA and SB enriched carbohydrate metabolism and amino acid metabolism pathways, thereby improving the utilization of carbohydrates. Pearson correlation analysis indicated that growth performance was closely related to hepatic lipid deposition, autophagy, antioxidant capacity, inflammation, and intestinal microbial composition.

Conclusions
In conclusion, dietary SA and SB can reduce hepatic lipid deposition; and alleviate oxidative stress and inflammation in largemouth bass fed on HC diet. These beneficial effects may be due to the altered composition of the gut microbiota caused by SA and SB. The improvement effects of SB were stronger than those associated with SA.
The effectiveness of a dialogical family guidance intervention regarding child treatment response in families with a child with neurodevelopmental disorders
Authors: Cavonius-Rintahaka Diana , Roos Mervi , Aho Anna Liisa 
Published: April 2024

Abstract
Background
Children with neurodevelopmental disorders (NDD) can have emotional and behavioral symptoms affecting not only the child, but the whole family. Since family members have a strong impact on each other, studies highlight the need to offer effective family interventions to strengthen the wellbeing of the family. The aim of the current study is to clarify whether there is a difference between parents` opinions regarding their child`s emotional and behavioral condition immediately after Dialogical Family Guidance (DFG) has ended and after a three and six month follow-up.

Method
Fifty families with a child with NDD were randomized into two groups. Group 1 received DFG with an immediate starting point, and Group 2 received DFG after a three-month waiting period. Parent experiences of treatment response regarding their children`s emotional and behavioral symptoms were estimated before and after DFG using the parent version of the Strengths and Difficulties Questionnaire (SDQ-p) at baseline, and after three and six months. Additionally, comparisons between boys and girls, and the age of the child were analyzed.

Results
The total difficulties score between Group 1 and Group 2 showed no difference immediately after DFG, or after three months. Regarding subdomains boys had more peer problems than girls, and at baseline, children between 3 and 6 years appeared to have more conduct problems than children between 7 and 13 years. Subdomain prosocial behavior increased statistically significantly during the study period in Group 1. Other SDQ-p subdomains remained constant in both groups between baseline and three and six month follow-up.

Conclusions
The result does not show any differences between parents` opinions regarding their child immediately after or three months after DFG regarding SDQ-p total difficulties scores in either group. The difference between younger and older children regarding conduct problems at baseline, and the difference between boys and girls regarding peer problems is worth paying attention to in the clinical setting. Because of the small sample, it is not possible to draw relevant conclusions regarding the intervention`s effect regarding the child`s mental health dimensions, gender, or age. Nevertheless, Dialogical family Guidance represents one intervention that can be used.

Trial registration
ClinicalTrials.gov NCT04892992 (retrospectively registered May 18th 2021).
Quantitative research on the degree of disorder of traditional settlements: a case study of Liangjia Village, Jingxing, Hebei Province
Authors: Peng Peng , Fu Yating , Zhou Xiangyun , Wu Shaopu , Zhao Jiajie , Zhang Yuechen 
Published: April 2024

Abstract
Traditional settlements are vital carriers of Chinese history and culture, reflecting the direct and original needs of generations. However, the modernization of settlements will inevitably disrupt the spontaneous growth patterns inherent in traditional settlements. The degree of disorder of the settlement is not only the embodiment of its form, but also the concrete manifestation of its construction intention. We use the degree of disorder in settlements to assess the construction intentions of the settlements, the results allow us to assess whether new planning aligns with the original construction logic, thereby assessing the extent of interference by modernization in traditional villages. This can provide guidance and assistance for settlement conservation and future planning. By using the Delaunay triangulation network, street polar histogram and direction entropy, and comprehensibility of settlements, this paper quantitatively analyzes the degree of disorder in the three levels of architecture, street and local environment of the settlement. Liangjia Village, the example in this research, is divided into three areas—two new and one old. degree of disorders in architecture, streets, and local environment are calculated and compared with the overall settlement. The study finds that the construction logic for buildings and streets remains stable throughout development. However, notable differences exist in environmental construction principles between new and old sections. The analysis suggests that traditional settlements, guided by inherent principles, maintain stability under external influences, serving as a benchmark for future planning and modernization decisions.
Assessment of the surface forest fuel load in the Ukrainian Polissia
Authors: Sydorenko S. , Gumeniuk V. , De Miguel-Díez F. , Soshenskiy O. , Budzinskyi I. , Koren V. 
Published: April 2024

Abstract
Background
There is a clearly increasing trend of wildfires that become catastrophic in some countries such as the United States, Australia, Russia, Portugal, Greece, and Spain. Fuel is one of the key components that influences fire behavior and its effects. Assessing the fuel load and distribution of its components in the landscape provides effective fire management treatments in terms of fire prevention campaigns on a scientific basis. This study aims to evaluate the litter, duff, and herb fuels in highly flammable coniferous forest types in Ukrainian Polissia.
To estimate relationships between forestry variables that reflect the characteristics of the pine stand (DBH, height of the stand, age, relative density, stock of the plantation etc.) and the load of litter, duff, and herb fuels (CWD, FWD, litter, live grass, etc.), correlation analysis was used. To analyze difference between groups of sampling plots that have different forests, we use generalized linear mixed models including random effects of sampling plot type. Cluster analysis was performed using k-means partitioning method and Calinski-Harabasz criterion. To assess the significance of individual variables on which the variation of forest fuel depends, the random forest algorithm was used; for variable selection, we used two parameters: the percent increase in mean squared error and the Gini impurity index.

Results
The research revealed that in the pine forest stands, the stock of litter and duff varies from 15.5 (15 years) to 140 ton/ha (139 years). When modeling, the humidity level of the forest site (soil) significantly affects the dynamics of forest fuel accumulation. In fresh types of forest-growing conditions, the forest litter stock increases to the age of 80–90 years; then, it strongly decreases, while in wet forest types, continuous forest fuel stock accumulation is established during the entire growth period. Moreover, the results showed that the forest fuel load was influenced by the soil fertility. The stock of live and dead herbaceous fuel in fresh and wet conditions is not statistically different, and soil moisture has not had a significant impact. Fine woody debris stocks were more dependent on stand productivity and practically does not depend on the soil fertility index, site moisture content, and its age and ranged from 0.4 to 1.9 t/ha (1 h), from 0.1 to 2.2 t/ha (10 h), and from 0 to 1.6 t/ha (100 h).

Conclusions
The obtained results enabled to develop mathematical models for estimating litter and duff stocks in the Polissia forest stands based on stand characteristic and the soil humidity level. Moreover, the results will serve as basis to develop local forest fuel models as well as to determine potential fire hazards and a fire behavior modeling process in coniferous forests of that region. These models constitute the basis for the national set of fuel model development for each nature zone of Ukraine.
Biomineralized synthesis of luminescent protease-(NH4)2Y3F11•H2O hybrid nanospheres and their applications as a stable and reusable enzyme reactor
Authors: Wei Wenyu , He Manman , Ma Jianrui , He Huixia , Liu Peng , Xiao Jianxi 
Published: April 2024

AbstractProteases, such as trypsin, are essential for extracting collagen in various industrial applications. The potential applications of rare earth nanomaterials, specifically yttrium nanoparticles, have attracted significant interest across various fields due to their distinctive characteristics, including high dielectric constant and thermal stability. Biomineralization has emerged as a promising approach to synthesize protein-inorganic nanomaterials with hierarchical structures and desired functions. In the present investigation, a novel protease-templated biomineralization strategy was developed for synthesizing protease-(NH4)2Y3F11•H2O hybrid nanomaterials using a one-pot method under very mild conditions. For modifying the morphologies of (NH4)2Y3F11•H2O throughout biomineralization, protease has been demonstrated to be a highly promising biotemplate. Protease was utilized as a template for morphological control in the biomineralization procedure, which resulted in a gradual transformation of the initially formed (NH4)2Y3F11•H2O octahedral structures into uniform nanospheres. The applicability of this approach was supported by successfully utilizing various proteases to synthesize protease-(NH4)2Y3F11•H2O hybrid nanospheres. In addition to a strong and desirable luminescent signal, these hybrid nanospheres demonstrated extensive recycling because of their high enzymatic activity, stability and durability. The protease-mediated biomineralization approach offers an easy and robust approach to develop innovative protease-inorganic composites. Its moderate reaction conditions and simple operation render it a viable tool for developing stable and reusable enzyme reactors in various industrial applications.
Graphical Abstract
Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study
Authors: Tonai Ken , Katayama Shinshu , Koyama Kansuke , Imahase Hisashi , Nunomiya Shin 
Published: April 2024

Abstract
Background
Sepsis-3 emphasizes the recognition of sepsis-induced cellular metabolic abnormalities, and utilizes serum lactate level as a biomarker of cellular metabolic abnormalities. Magnesium plays an important role as a cofactor in glucose metabolism, although it is not well known that magnesium deficiency causes elevated serum lactate levels. Additionally, it remains unclear how magnesium status affects the role of serum lactate levels as a marker of metabolic abnormalities in sepsis. Thus, this study aimed to investigate the association between serum magnesium and lactate levels in patients with sepsis and explore this relationship from the perspectives of time course and circulatory abnormalities.

Methods
This retrospective observational study of adult patients with sepsis was performed at the 16-bed intensive care unit of Jichi Medical University Hospital between June 2011 and December 2017. The relationship between serum magnesium and lactate levels for 5 days from intensive care unit admission was investigated along the time course. Multivariate logistic regression analysis was performed to evaluate the association between serum magnesium and lactate levels during intensive care unit admission.

Results
Among 759 patients included, 105 had hypomagnesemia (magnesium level < 1.6 mg/dL), 558 had normal serum magnesium levels (1.6–2.4 mg/dL), and 96 had hypermagnesemia (magnesium level > 2.4 mg/dL) at intensive care unit admission. From intensive care unit admission to day 5, the hypomagnesemia group had higher serum lactate levels and a higher frequency of lactic acidosis than the normal magnesium level and hypermagnesemia groups (70% vs. 51.6% vs. 50%; P < 0.001). Hypomagnesemia at intensive care unit admission was independently associated with lactic acidosis, i.e., lactic acid level > 2 mmol/L (odds ratio, 2.76; 95% confidence interval, 1.60–4.76; P < 0.001).

Conclusions
Hypomagnesemia was associated with serum lactate levels in the early and post-resuscitation phases of sepsis. Further studies are needed to elucidate whether the magnesium status is associated with sepsis-induced cellular and metabolic abnormalities.
Arbitrary target frequency cloaking for flexural waves using deep learning
Authors: Linghu Zhiang , Du Qiujiao , Shen Yawen , Yang Hongwu , Peng Pai , Liu Fengming 
Published: April 2024

Abstract
Differing from electromagnetic and acoustic waves, the governing equation for elastic waves in flexural plates is not form invariant, hindering straightforward cloak design based on coordinate transformation theory. In this work, we propose a novel idea instead of the approximately equivalent transformation method, and employ scattering cancellation techniques to design a multi-layer cylindrical structure for achieving flexural wave cloaking at desired target frequencies. Moreover, we use deep learning to effectively address the time consuming issue dealing with fine-tuning design parameters for the desired response. More importantly, we adopt a method based on a tandem neural network to tackle the one-to-many mapping challenge in inverse design. It not only accurately predicts the scattering spectra of multi-layer structures in advance but also efficiently performs inverse design to obtain the required design parameters for arbitrary target frequency cloaking.
Numerical calculation of N-periodic wave solutions of the negative-order Korteweg-de Vries equations
Authors: Wang Yu , Zhao Zhonglong , Zhang Yufeng 
Published: April 2024

Abstract
In this paper, the N-periodic wave solutions of the negative-order Korteweg-de Vries equations are presented, which can be used to describe wave phenomena in the water waves and plasma waves. Combining the bilinear Bäcklund transformation with the Riemann-theta function, the N-periodic wave solutions can be obtained. Employing the parity of the bilinear forms for the Bäcklund transformation, the complexity of the calculation can be reduced. The difficulty of solving N-periodic wave solutions can be transformed into solving least square problems. The Gauss-Newton numerical algorithm is employed to solve this kind of problem. Furthermore, the characteristic lines are used to analyze quantitatively the quasi-periodic solutions. The characteristic line analysis method is specifically demonstrated in the case of N = 3. Some examples of numerical simulations for the 3-periodic and 4-periodic waves are presented. It is proved that this method can be further extended to the N-periodic wave solutions.
Acute Treatment of Migraine
Authors: Burch Rebecca 
Published: April 2024

ABSTRACT

Objective
Most patients with migraine require acute treatment for at least some attacks. This article reviews the approach to the acute treatment of migraine, migraine-specific and nonspecific treatment options, rescue treatment and options for management in the emergency department and inpatient settings, and treatment during pregnancy and lactation.

Latest Developments
Triptans, ergot derivatives, and nonsteroidal anti-inflammatory drugs have historically been the main acute treatments for migraine. The development of new classes of acute treatment, including the small-molecule calcitonin gene-related peptide receptor antagonists (gepants) and a 5-HT1F receptor agonist (lasmiditan), expands available options. These new treatments have not been associated with vasospasm or increased cardiovascular risk, therefore allowing migraine-specific acute treatment for the more than 20% of adults with migraine who are at increased risk of cardiovascular events. Neuromodulation offers a nonpharmacologic option for acute treatment, with the strongest evidence for remote electrical neuromodulation.

Essential Points
The number of available migraine treatments continues to expand, although triptans are still the mainstay of migraine-specific acute treatment. There is no one-size-fits-all acute treatment and multiple treatment trials are sometimes necessary to determine the optimal regimen for patients. Switching within and between classes, using the maximum allowed dose, using combination therapy, and counseling patients to treat early are all strategies that may improve patient response to acute treatment.
Indomethacin-Responsive Headache Disorders
Authors: Goadsby Peter J. 
Published: April 2024

ABSTRACT

Objective
This article describes the clinical features and treatment of the indomethacin-responsive headache disorders paroxysmal hemicrania and hemicrania continua.

Latest Developments
Both paroxysmal hemicrania and hemicrania continua are treated with indomethacin at the lowest clinically useful dose. It has recently become clear that some patients with either condition may respond to treatment with noninvasive vagus nerve stimulation, which can be both indomethacin sparing and, in some cases, headache controlling. Given the lifelong nature of both paroxysmal hemicrania and hemicrania continua, brain imaging with MRI is recommended when the conditions are identified, specifically including pituitary views.

Essential Points
Paroxysmal hemicrania and hemicrania continua are indomethacin-responsive headache disorders that offer a rewarding and unique opportunity to provide marked clinical improvement when recognized and treated appropriately. These disorders share the final common pathway of the trigeminal-autonomic reflex, with head pain and cranial autonomic features, and are differentiated pathophysiologically by the pattern of brain involvement, which can be seen using functional imaging. They have distinct differential diagnoses to which the clinician needs to remain alert.
Cluster Headache, SUNCT, and SUNA
Authors: Burish Mark 
Published: April 2024

ABSTRACT

Objective
This article reviews the epidemiology, clinical features, differential diagnosis, pathophysiology, and management of three types of trigeminal autonomic cephalalgias: cluster headache (the most common), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA).

Latest Developments
The first-line treatments for trigeminal autonomic cephalalgias have not changed in recent years: cluster headache is managed with oxygen, triptans, and verapamil, and SUNCT and SUNA are managed with lamotrigine. However, new successful clinical trials of high-dose prednisone, high-dose galcanezumab, and occipital nerve stimulation provide additional options for patients with cluster headache. Furthermore, new genetic and imaging tests in patients with cluster headache hold promise for a better understanding of its pathophysiology.

Essential Points
The trigeminal autonomic cephalalgias are a group of diseases that appear similar to each other and other headache disorders but have important differences. Proper diagnosis is crucial for proper treatment.
Diversity, Equity, and Inclusion in Headache Care and Research
Authors: Kiarashi Jessica , Halker Singh Rashmi B. 
Published: April 2024

ABSTRACT
This article reviews the disparities faced by individuals who experience headache disorders and discusses potential solutions to deliver equitable care. Disparities exist in the diagnosis and treatment of headache disorders with regard to race, ethnicity, sex, gender, sexual orientation, geography, and socioeconomic status. Furthermore, research in the realm of headache disparities is inadequate, and the clinical trial representation of patients from underserved communities is poor. Many barriers exist to optimizing care for underserved communities and this article addresses these barriers and presents ways to combat them.
Political Determinants of Health: Health Care Privatization and Population Health in Europe
Authors: Moise Alexandru D. , Popic Tamara 
Published: April 2024

Abstract
Context: The extent to which health care reforms affect health remains understudied. Health care reforms result in policy outputs that determine provision of medical services, which have consequences for the health of the population. The authors scrutinize this relationship between health policy outputs and population health by focusing on legislative changes implying privatization of health care delivery and finance. They ask the following question: What is the relationship between reforms that privatize health care provision and population health in terms of health outcomes and inequalities?
Methods: They answer this question by relying on fixed-effects time-series cross-section models. The authors use an original dataset of health care reforms passed in 36 European countries from 1989 to 2019. Health outcomes are operationalized with measures of subjective health status, unmet health needs, and resulting health inequalities.
Findings: Their results show that privatization of health care is associated with higher rates of bad subjective health and unmet health needs several years after the passing of reforms. These effects are stronger for individuals in the lower tiers of income and education, resulting in greater socioeconomic inequalities.
Conclusions: The article contributes to conceptualization of the political determinants of health as health policy outputs and a better understanding of the relationship between policy outputs and population health outcomes.