bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Mg alloying and cooling rate on the microstructure of silicon
Authors: Zhu Mengyi , Safarian Jafar , Irvansyah Mochamad Ilham Al Fariesy , Di Sabatino Marisa 
Published: March 2024

In response to the escalating global demand for solar photovoltaic (PV) energy, there is a critical need for more cost-effective and environmentally sustainable production methods for upgrading metallurgical-grade silicon (MG-Si). Among various metallurgical approaches, acid leaching is an economical and effective method to upgrade MG-Si. However, the impact of cooling rates during solidification, a potentially significant factor for optimization of the leaching process, has been rarely investigated. In this work, the effects of magnesium alloying content and cooling rate on microstructural evolutions in MG-Si are studied. MG-Si was alloyed with two different magnesium contents (5.5 wt% and 9.0 wt%), using an induction furnace for the melting, alloying, and casting process. The cast alloys were subsequently remelted under five distinct cooling rates, specifically 3, 10, 25, 40, and 80°C/min. Microstructural analysis and grain size measurement were conducted using scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and the ASTM E112 standards. It was observed that the Mg2Si phase was formed along the primary Si grains and with other intermetallic silicide-containing impurities embedded inside. Moreover, higher cooling rates resulted in finer primary Si grains with highly diverse crystallographic orientations, while slower rates induced coarser Si grains and a concentrated silicide phase along the grain boundaries. Importantly, the results also indicate that a higher magnesium alloying content (9.0 wt%) led to finer grain sizes. The present work establishes links between alloying content, cooling rate, and the resulting microstructure, offering valuable insights for optimizing the alloying–leaching process.
Optimized barley phytase gene expression by focused FIND-IT screening for mutations in cis-acting regulatory elements
Authors: Madsen Claus Krogh , Brearley Charles Alistair , Harholt Jesper , Brinch-Pedersen Henrik 
Published: March 2024

IntroductionInduced modification of plant gene expression is of both fundamental and applied importance. Cis-acting regulatory elements (CREs) are major determinants of the spatiotemporal strength of gene expression. Yet, there are few examples where induced genetic variation in predetermined CREs has been exploited to improve or investigate crop plants. MethodsThe digital PCR based FIND-IT technology was applied to discover barley mutants with CRE variants in the promoter of the nutritional important barley grain phytase (PAPhy_a) gene. Results and discussionMutants with higher or lower gene expression and ultimately higher or lower mature grain phytase activity (MGPA), respectively, were discovered. Field trials and inositol phosphate profiling during germination showed that PAPhy_a does not influence agronomic performance under the trial conditions but it does shorten the lag time of phosphate mobilization during germination. Higher endogenous MGPA is an improvement of grain quality for feed use as it improves the phosphate bioavailability for monogastric animals. Moreover, as the targeted CRE motifs of the PAPhy_a promoter are shared with a range of seed expressed genes like key cereal and legume storage genes, the current results demonstrates a concept for modulating individual gene expression levels of a range of seed genes.
A retrospective big data study using healthcare insurance claims to investigate the role of comorbidities in receiving low vision services
Authors: Stolwijk M. L. , van Nispen R. M. A. , van der Pas S. L. , van Rens G. H. M. B. 
Published: March 2024

IntroductionThe aim was to examine the association between physical and mental comorbidity with receiving low vision services (LVS).MethodsA retrospective study based on Dutch claims data of health insurers was performed. We retrieved data (2015–2018) of patients (≥18 years) with eye diseases causing severe vision loss who received LVS at Dutch rehabilitation organizations in 2018 (target group) and patients who did not receive LVS, but who received ophthalmic medical specialist care for glaucoma, macular, diabetic retinal and/or retinal diseases in 2018 (reference group). For examining the association between the patients' comorbidities and receiving LVS, multivariable logistic regression was used. The relative quality of five different models was assessed with the Akaike Information Criterion (AIC).ResultsThe study population consisted of 574,262 patients, of which 8,766 in the target group and 565,496 in the reference group. Physical comorbidity was found in 83% and 14% had mental comorbidity. After adjustment for all assumed confounders, both physical and mental comorbidity remained significantly associated with receiving LVS. In the adjusted model, which also included both comorbidity variables, the best relative quality was found to describe the association between mental and physical comorbidity and receiving LVS.ConclusionsMental comorbidity seemed to be independently associated with receiving LVS, implying that the odds for receiving a LVS referral are higher in patients who are vulnerable to mental comorbidity. Physical comorbidity was independently associated, however, the association with receiving LVS might not be that meaningful in terms of policy implications. Providing mental healthcare interventions for people with VI seems warranted.
The Combined Analysis of the Transcriptome and Metabolome Revealed the Possible Mechanism of Flower Bud Formation in Amorphophallus bulbifer
Authors: Li Wenchao , Xu Peng , Qian Cheng , Zhao Xing , Xu Huini , Li Kunzhi 
Published: March 2024

The flowering of Amorphophallus bulbifer (A. bulbifer) plays an important role in its reproduction. The flowers and leaves of A. bulbifer cannot grow at the same time. However, the physiological and molecular mechanisms involved in flower bud and leaf bud formation are still unclear. In this study, the flower buds and leaf buds of A. bulbifer in the early stage of growth were used as research materials, transcriptome and metabolome analyses were carried out, and the soluble sugar and starch contents of A. bulbifer corms were determined. Transcriptome analysis revealed 5542 differentially expressed genes (DEGs) between flower buds and leaf buds, 3107 of which were upregulated and 2435 of which were downregulated. Enrichment analysis of the KEGG pathway showed that these differential genes were enriched mainly in the plant hormone signal transduction, DNA replication and fatty acid elongation pathways. A total of 5296 significant differentially abundant metabolites were screened out by nontargeted metabolomics analysis. The differentially abundant metabolites were functionally classified in the HMDB, and 118 were successfully matched, including 17 that were highly expressed in flower buds. The differentially abundant metabolites in the flower buds were mainly enriched in pathways such as amino acid metabolism, isoquinoline alkaloid biosynthesis and pyrimidine metabolism. Targeted metabolomics analysis revealed that the contents of ABA, ZT and iPA in flower buds were significantly greater than those in leaf buds, while the opposite trend was observed for IAA. The analysis of soluble sugar and starch contents showed that the starch and soluble sugar contents in flower buds were significantly greater than those in leaf buds. The results of this study showed that flower bud development in A. bulbifer was regulated by amino acids, starch, ABA, ZT, iPA, IAA and other hormones. These findings could lead to valuable genetic resources for further study of A. bulbifer flowering and provide a deeper understanding of the molecular basis of A. bulbifer flowering.
Excited State Calculations of Cu-Doped Anatase TiO2 (101) and (001) Nanofilms
Authors: Lin Yin-Pai , Neilande Elina , Bandarenka Hanna , Zavatski Siarhei , Isakoviča Inta , Piskunov Sergei , Bocharov Dmitry , Kotomin Eugene A. 
Published: March 2024

Excited state calculations are performed to predict the electronic structure and optical absorption characteristics of Cu-doped anatase TiO2 nanofilms, focusing on their (101) and (001) surface terminations. Using model structures that successfully represent the equilibrium positions of deposited Cu atoms on the TiO2 surface, a comprehensive analysis of the absorption spectra for each considered model is made. The proposed modeling reveals phenomena when photogenerated electrons from TiO2 tend to accumulate in the vicinity of the deposited Cu atoms exposed to photon energies surpassing the band gap of TiO2 (approximately 3.2 eV). The crucial transition states that are essential for the creation of potential photocatalytic materials are identified through detailed calculations of the excited states. These insights hold substantial promise for the strategic design of advanced photocatalytic materials. The obtained results provide a base for subsequent analyses, facilitating the determination of heightened surface reactivity, photostimulated water splitting, and antibacterial properties.
Interventions to improve medication adherence in adults with mental–physical multimorbidity in primary care: a systematic review
Authors: Lammila-Escalera Elena , Greenfield Geva , Pan Ziyang , Nicholls Dasha , Majeed Azeem , Hayhoe Benedict 
Published: March 2024

BackgroundMedication non-adherence is a notable contributor to healthcare inefficiency, resulting in poor medication management, impaired patient outcomes, and ineffective symptom control.AimTo summarise interventions targeting medication adherence for adults with mental–physical multimorbidity in primary healthcare settings.Design and settingA systematic review of the literature — published in any language and with any country of origin — was conducted.MethodMEDLINE, EMBASE, PsycInfo, Web of Science, Cochrane Library, and the Cumulated Index to Nursing and Allied Health Literature — more commonly known as CINAHL — were searched for relevant studies. Data were extracted and synthesised using narrative synthesis. The Effective Practice and Organisation of Care (EPOC) taxonomy was used to classify intervention types. Risk of bias was assessed using the National Heart, Lung, and Blood Institute’s quality assessment tool for controlled intervention studies.ResultsEleven studies, representing 2279 patients, were included. All interventions examined were classified into one EPOC domain, namely ‘delivery arrangements’. All included studies examined patients who had a physical condition and depression. Seven studies examining interventions focused on coordination of care and management of care processes reported statistically significant improvements in medication adherence that were attributed to the intervention. Four studies considering the use of information and communication technology observed no changes in medication adherence.ConclusionInterventions that coordinate and manage healthcare processes may help improve patients’ adherence to medication regimes in those with mental–physical multimorbidity. However, it is still necessary to better understand how digital health technology can support patients in following their medication regimes. As the growing challenges of treating multimorbidity are faced, everyone involved in health services — from providers to policymakers — must be receptive to a more integrated approach to healthcare delivery.
Information needs for GPs on type 2 diabetes in Western countries: a systematic review
Authors: Andersen Tue Helms , Marcussen Thomas Møller , Nørgaard Ole 
Published: March 2024

BackgroundMost people with type 2 diabetes receive treatment in primary care by GPs who are not specialised in diabetes. Thus, it is important to uncover the most essential information needs regarding type 2 diabetes in general practice.AimTo identify information needs related to type 2 diabetes for GPs.Design and settingSystematic review focused on literature relating to Western countries.MethodMEDLINE, Embase, PsycInfo and CINAHL were searched from inception to January 2024. Two researchers conducted the selection process, and citation searches were performed to identify any relevant articles missed by the database search. Quality appraisal was conducted with the Mixed Methods Appraisal Tool. Meaning units were coded individually, grouped into categories, and then studies were summarised within the context of these categories using narrative synthesis. An evidence map was created to highlight research gaps.ResultsThirty-nine included studies revealed eight main categories and 36 subcategories of information needs. Categories were organised into a comprehensive hierarchical model of information needs, suggesting ‘Knowledge of guidelines’ and ‘Reasons for referral’ as general information needs alongside more specific needs on ‘Medication’, ‘Management’, ‘Complications’, ‘Diagnosis’, ‘Risk factors’, and ‘Screening for diabetes’. The evidence map provides readers with the opportunity to explore the characteristics of the included studies in detail.ConclusionThis systematic review provides GPs, policymakers, and researchers with a hierarchical model of information and educational needs for GPs, and an evidence map showing gaps in the current literature. Information needs about clinical guidelines and reasons for referral to specialised care overlapped with needs for more specific information.
Atuação fonoaudiológica em paciente vítima de ferimento por arma de fogo na cavidade oral e região cervical: relato de caso
Authors: Pinheiro Joana de Azevedo , Soares Letícia Barreto Ramos , Dos Santos Alef Morais , Albuquerque Junior Jose Wilson de Araújo , Torres Elder Nayan de Jesus 
Published: March 2024

Introdução: a disfagia é um sintoma que indica comprometimento na deglutição ocasionado por diversos fatores, entre eles: trauma em região da cabeça e pescoço e intubação orotraqueal prolongada. O tratamento das alterações da deglutição deve envolver uma equipe multidisciplinar. O objetivo foi descrever a atuação fonoaudiológica em paciente vítima de ferimento por arma de fogo na cavidade oral e região cervical. Apresentação do caso: Paciente, sexo feminino, deu entrada no hospital, diagnosticada com trauma de face, passou por procedimento cirúrgico, necessitou de ventilação mecânica invasiva, uso via alternativa de alimentação e traqueostomia. Resultados: Paciente passou por avaliação e intervenção fonoaudiológica para definição de via respiratória em equipe, e definição da via de alimentação. Discussão: dentre as etapas mais importantes no processo de decanulação, destacam-se desinsuflação do cuff; permeabilidade de vias aéreas, avaliação da deglutição, gerenciamento das secreções e treino de oclusão da traqueostomia e que o fonoaudiólogo é o profissional responsável em avaliar e reabilitar as funções estomatognáticas, reduzindo ao máximo o tempo de uso das vias alternativas de alimentação. Conclusão: Proporcionou mais informações sobre a atuação e técnicas fonoaudiológicas, no desmame de dispositivos, em pacientes com trauma de face.
Perfil e prevalência da hanseníase no Nordeste no período de 2018 a 2022
Authors: Nobre Maria Eduarda Wanderley , Afonso Sophya Carla Cedrim Cavalcante , da Silva Maria Karolyna Cedrim Gomes , Braga Anna Luiza Pereira , Fachin Laercio Pol 
Published: March 2024

Introdução: A hanseníase é uma doença infectocontagiosa, causada pela bactéria Mycobacterium leprae ou bacilo de Hansen. Compreendida como uma das mais antigas enfermidades da humanidade, ainda hoje possui repercussões significativas na população mundial, sendo considerada um problema de saúde pública. Segundo a Organização Mundial de Saúde (OMS), o Brasil é um país de alta carga da doença, ocupando o segundo lugar no ranking de casos, sendo o Nordeste classificado como a terceira região de maior incidência do país. Objetivos: Avaliar a prevalência e o perfil epidemiológico da Hanseníase no Nordeste brasileiro no período de 2018 a 2022. Metodologia: Trata-se de um estudo epidemiológico de caráter quantitativo, cujos dados foram coletados a partir do SINAN/DATASUS, tendo como variáveis: sexo, raça, faixa etária e quantidade de lesões existentes no momento do diagnóstico. Resultados: A Região Nordeste apresentou mais de 61 mil novos casos de Hanseníase no período de 2018-2022, mostrando-se como a Região do Brasil com maior incidência, representando aproximadamente 42% dos casos diagnosticados nacionalmente nesse período. Notou-se ainda maior prevalência em pessoas do sexo masculino, raça parda, adolescentes/adultos (maiores de 15 anos) e com presença de cinco ou mais lesões na pele (forma multibacilar). Conclusão: A região Nordeste ainda apresenta alta incidência de novos casos diagnosticados em relação aos dados obtidos no restante do país, sendo homens, maiores de 15 anos e da raça parda os mais afetados por essa doença.
Hipotensão em raquianestesia durante cesariana: fatores na prevenção e manejo
Authors: Naresse João Vitor de Freitas , Antognolli Sérgio Ricardo Del Bel , Silva Filho Antônio José Magalhães , Sousa Vinicius Gabriel , Silva Diogo Augusto Martins , Samora Rafael Assis , Severino Henrique Baisch , Duarte João Vitor Figueiredo , Rocha João Vitor Sarmento , Queiroz Felipe Silva , Queiroz Bruno Silva , Rogalli Arthur Sousa 
Published: March 2024

INTRODUÇÃO: A cesariana (CS) consiste num procedimento realizado com importante frequência em todo o mundo, sendo a raquianestesia o método de escolha para esse procedimento. A raquianestesia possui efeitos adversos indesejados, entre eles destaque para o principal: a hipotensão. OBJETIVOS: Analisar os efeitos da raquianestesia em gestantes durante a cesariana, principalmente a hipotensão. METODOLOGIA: Trata-se de uma revisão integrativa na base de dados PUBMED utilizando os descritores “Anesthesia spinal AND Cesarean AND Hypotension’’ para artigos publicados entre 2018 e 2024. RESULTADOS: A incidência de hipotensão materna pode estar relacionada diretamente à presença de comorbidaddes da mãe em 62,6% dos casos. A hipotensão está relacionada a até 2,6% de acidose fetal. A fenilefrina pode ser usada como vasopressor nesses cenários. A noroepinefrina parecer ter vantagens em relação à fenilefrina. CONCLUSÃO: Devem ser incentivadas novas pesquisas sobre o manejo, bem como possibilidades frente à prevenção da hipotensão intrarraquianestesia.
Dor abdominal no paciente cirúrgico idoso: uma revisão de literatura
Authors: Emmel Larissa Muller , Caeran Mariana , Hoffmann Mairim Bordin , Ribeiro Arthur Gomes , Bortolini Bianca , Schuck Fernanda Wartchow , Tosta Gabriel Felipe , Swarowsky Dóris Medianeira Lazzarotto 
Published: March 2024

A dor abdominal no paciente cirúrgico idoso é um desafio não somente no seu reconhecimento, mas também no seu diagnóstico. Essa revisão tem por objetivo evidenciar os desafios diagnósticos da dor abdominal aguda em pacientes idosos que possam cursar com afecções cirúrgicas, estabelecendo quais fatores contribuem para o atraso no diagnóstico. A polifarmácia, as alterações psicossociais e as comorbidades subsidiam os demais âmbitos da senilidade que contribuem para o avanço do curso da doença e o diagnóstico tardio, bem como a já instalada gravidade no momento da procura por atendimento médico, em alguns casos. A metodologia empregada neste trabalho baseia-se na revisão de literatura, por meio de buscas de artigos nas seguintes plataformas de pesquisa: PubMed e Scopus. Por meio da revisão literária, concluiu-se que a suspeição é um meio de extrema importância em quadros de dor abdominal de causa cirúrgica nesse público, pois está associado ao atraso na procura de atendimento médico, juntamente com dificuldade de reconhecimento quando o quadro é de manejo cirúrgico ou clínico. O atraso no diagnóstico da dor abdominal pode gerar uma intervenção tardia, piorando não somente o curso da doença, mas como o prognóstico e desfecho desfavorável, sendo necessária a discussão do porquê é fundamental valorizar, reconhecer e manejar uma dor abdominal no público senil.
Desde el sistema de gestión de calidad a la seguridad de la información propuesta en ISO 27001
Authors: García Marcelo Adrián , Masclef María Alejandra 
Published: March 2024

La información de una organización constituye un activo valioso y vulnerable. Un ataque puede comprometerla total o parcialmente y afectar su disponibilidad, integridad y/o confidencialidad, causando retrasos y un alto costo económico y reputacional para la compañía. Es por ello, que la implementación de un Sistema de Gestión de Seguridad de la Información (SGSI) contribuiría con el propósito de proteger la información y los activos informáticos relacionados.
El objetivo de este trabajo es analizar el estado actual del Sistema de Gestión (SG), certificado por IRAM – ISO 9001 en calidad (SGC), implementado en una empresa dedicada a la comercialización de productos químicos para la industria, ubicada en la provincia de Tucumán, Argentina. A partir de ello, se realizará un estudio de tipo exploratorio y descriptivo, analizando los requerimientos que adicionalmente debería cumplir la organización para certificar su SG en el marco de ISO 27001 (requisitos para la implementación de un SGSI).
Cabe destacar, que las normas mencionadas cuentan con una estructura de alto nivel con apartados de títulos idénticos, términos comunes y, entre otros, definiciones esenciales indicadas en el anexo SL de la Directiva ISO/IEC, parte 1, “Consolidated ISO Supplement”, lo que hace que su implementación conjunta sea compatible.
A partir de la solicitud por parte de la empresa de incorporar controles de seguridad en sus procesos críticos de negocios, se considera que la implementación de un sistema de gestión que cumpla simultáneamente con requerimientos de Calidad y Seguridad de la Información, se presenta como una propuesta de extensión factible para la entidad objeto de estudio. Ello contribuiría a la mejora continua de sus procesos y a la definición de un umbral aceptable de riesgo asociado a la utilización de sus activos de información