bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Minimalistic Covalent Bond‐Forming Chemical Reaction Cycle that Consumes Adenosine Diphosphate
Authors: Marchetti Tommaso , Roberts Benjamin M. W. , Frezzato Diego , Prins Leonard J. 
Published: March 2024

AbstractThe development of synthetic active matter requires the ability to design materials capable of harnessing energy from a source to carry out work. Nature achieves this using chemical reaction cycles in which energy released from an exergonic chemical reaction is used to drive biochemical processes. Although many chemically fuelled synthetic reaction cycles that control transient responses, such as self‐assembly, have been reported, the generally high complexity of the reported systems hampers a full understanding of how the available chemical energy is actually exploited by these systems. This lack of understanding is a limiting factor in the design of chemically fuelled active matter. Here, we report a minimalistic synthetic responsive reaction cycle in which adenosine diphosphate (ADP) triggers the formation of a catalyst for its own hydrolysis. This establishes an interdependence between the concentrations of the network components resulting in the transient formation of the catalyst. The network is sufficiently simple that all kinetic and thermodynamic parameters governing its behaviour can be characterised, allowing kinetic models to be built that simulate the progress of reactions within the network. While the current network does not enable the ADP‐hydrolysis reaction to populate a non‐equilibrium composition, these models provide insight into the way the network dissipates energy. Furthermore, essential design principles are revealed for constructing driven systems, in which the network composition is driven away from equilibrium through the consumption of chemical energy.
Calcium‐Ligand Cooperation Promoted Activation of N2O, Amine, and H2 as well as Catalytic Hydrogenation of Imines, Quinoline, and Alkenes
Authors: Liang Yaoyu , Efremenko Irena , Diskin‐Posner Yael , Avram Liat , Milstein David 
Published: March 2024

AbstractBond activation and catalysis using s‐block metals are of great significance. Herein, a series of calcium pincer complexes with deprotonated side arms have been prepared using pyridine‐based PNP and PNN ligands. The complexes were characterized by NMR and X‐ray crystal diffraction. Utilizing the obtained calcium complexes, unprecedented N2O activation by metal‐ligand cooperation (MLC) involving dearomatization‐aromatization of the pyridine ligand was achieved, generating aromatized calcium diazotate complexes as products. Additionally, the dearomatized calcium complexes were able to activate the N−H bond as well as reversibly activate H2, offering an opportunity for the catalytic hydrogenation of various unsaturated molecules. DFT calculations were applied to analyze the electronic structures of the synthesized complexes and explore possible reaction mechanisms. This study is an important complement to the area of MLC and main‐group metal chemistry.
Unveiling the Role of Water in Heterogeneous Photocatalysis of Methanol Conversion for Efficient Hydrogen Production
Authors: Xiao Mu , Baktash Ardeshir , Lyu Miaoqiang , Zhao Guangyu , Jin Yonggang , Wang Lianzhou 
Published: March 2024

AbstractWater molecules, which act as both solvent and reactant, play critical roles in photocatalytic reactions for methanol conversion. However, the influence of water on the adsorption of methanol and desorption of liquid products, which are two essential steps that control the performance in photocatalysis, has been well under‐explored. Herein, we reveal the role of water in heterogeneous photocatalytic processes of methanol conversion on the platinized carbon nitride (Pt/C3N4) model photocatalyst. In situ spectroscopy techniques, isotope effects, and computational calculations demonstrate that water shows adverse effects on the adsorption of methanol molecules and desorption processes of methanol oxidation products on the surface of Pt/C3N4, significantly altering the reaction pathways in photocatalytic methanol conversion process. Guided by these discoveries, a photothermal‐assisted photocatalytic system is designed to achieve a high solar‐to‐hydrogen (STH) conversion efficiency of 2.3 %, which is among the highest values reported. This work highlights the important roles of solvents in controlling the adsorption/desorption behaviours of liquid‐phase heterogeneous catalysis.
Guidelines in Practice: Manual High‐Level Disinfection
Authors: Speth Jennifer 
Published: March 2024

ABSTRACTThere are several steps involved when performing high‐level disinfection (HLD) of semicritical devices. The recently updated AORN “Guideline for manual high‐level disinfection” provides perioperative nurses with evidence‐based best practices for performing safe and effective HLD of reusable semicritical items. The guideline also addresses preventing injury to patients and health care workers associated with the handling of high‐level disinfectants. This article provides an overview of the guideline and discusses recommendations for selection of a processing method, sterile processing areas, preparation of items for HLD, preparation of high‐level disinfectants, manual HLD, drying and storage of items after HLD, and processing records. It also includes a scenario that illustrates specific concerns related to performing quality tests on high‐level disinfectant solutions. Perioperative nurses should review the guideline in its entirety and apply the recommendations when performing manual HLD.
pH‐Responsive itaconic acid‐based villous‐like hydrogels for water‐plugging materials
Authors: Xue Xiaojie , He Yueqi , Jia Runping , Qian Hongxiang , Lin Yongfei , Xu Xiaowei , Shi Jichao , Chang Shufang , Cui Aihua 
Published: March 2024

AbstractThe development of new methods to improve the water absorption performance of polymeric materials, taking into account their environmental friendliness, is a promising research direction in Itaconic acid based water‐absorbent polymeric materials. In this study, from the perspective of environmental protection, we propose to design highly absorbent hydrogels with a novel villous‐like structure by using hydrophilic itaconic acid as the raw material and combining it with a novel villous‐like network structure to substantially increase the contact area between the hydrogel and water, thus improving the water absorption rate of the hydrogel. Itaconic acid is water‐soluble and renewable. The widespread use of polymeric water‐absorbent polymers from traditional petroleum sources poses a serious threat to the sustainability of ecosystems, and therefore, itaconic acid has attracted much attention as an alternative to petroleum‐based polymers. The villous‐like network structure is inspired by the villi of the small intestine, the special presence of which expands the absorptive surface area of the small intestine by a factor of about 600, and it is therefore hypothesized that the introduction of this special structure could help the hydrogel to greatly increase the contact area with water and thus achieve the high water absorption properties of the hydrogel. This is also the first time that the villus‐like network structure has been applied to Itaconic acid based hydrogels. The results show that the hydrogel has the property of rapid water absorption and swelling and the water absorption rate of the hydrogel can reach up to 2210 g/g, and the villous‐like structure formed by the hydrogel can be observed in the SEM image. The water‐absorption test of the hydrogel showed that when the molar mass ratio of itaconic acid to acrylic acid was 1:4, the hydrogel absorbed water and swelled rapidly in a short time. The results of the water retention test showed that the hydrogel still existed after 5 days, and the water retention was greater than 86%. In addition, the hydrogel had high reusability, and the water absorption performance of the hydrogel could still reach 89.12% after 6 cycles of the water absorption test. Hydrogel with high water‐absorbing property has good application prospects as fast swelling material in the field of flood control of water conservancy projects.
Ultrasonic‐Assisted Nitrate Anion Incorporation in Triaminoguanidium Chloride Based Covalent Organic Polymer for Methylene Blue Dye Adsorption
Authors: Deori Naranarayan , Paul Saurav , Lahkar Surabhi , Brahma Sanfaori 
Published: March 2024

AbstractTerephthalaldehyde‐triaminoguanidium chloride covalent organic polymer, Te‐TGCl COP can facilely be incorporated with NaNO3 by sonication. Te‐TGCl COP incorporated with NaNO3 via ultrasonication adsorbs Methylene Blue (MB) dye. Te‐TGCl COP alone shows negligible adsorption capacity for MB, however, when treated with NaNO3, its adsorption capacity emerges slightly. Moreover, ultrasonication of the NaNO3 treated COP, Te‐TG‐NaNO3 COP shows dramatic increase in its adsorption capacity for MB (qe for Te‐TGCl COP ≈0 mg g−1; for Te‐TG‐NaNO3=17.65 mg g−1). Emergence of MB dye adsorption property in Te‐TG‐NaNO3 COP composite may be attributed primarily to the electrostatic interaction of MB dye molecules with nitrate anions and the sonochemical effect caused fibrous morphological structure of the adsorbent material. The kinetics of MB dye adsorption onto Te‐TG‐NaNO3 COP composite exhibits an excellent fit for the pseudo‐second order model, suggesting the rate‐determining step to be chemisorption. Homogeneous monolayer adsorption of MB dye onto Te‐TG‐NaNO3 COP composite can be suggested as the Langmuir isotherm model seemed to be fitted well.
Chewing through challenges: Exploring the evolutionary pathways to wood‐feeding in insects
Authors: Beza‐Beza Cristian F. , Wiegmann Brian M. , Ware Jessica A. , Petersen Matt , Gunter Nicole , Cole Marissa E. , Schwarz Melbert , Bertone Matthew A. , Young Daniel , Mikaelyan Aram 
Published: March 2024

AbstractDecaying wood, while an abundant and stable resource, presents considerable nutritional challenges due to its structural rigidity, chemical recalcitrance, and low nitrogen content. Despite these challenges, certain insect lineages have successfully evolved saproxylophagy (consuming and deriving sustenance from decaying wood), impacting nutrient recycling in ecosystems and carbon sequestration dynamics. This study explores the uneven phylogenetic distribution of saproxylophagy across insects and delves into the evolutionary origins of this trait in disparate insect orders. Employing a comprehensive analysis of gut microbiome data, from both saproxylophagous insects and their non‐saproxylophagous relatives, including new data from unexplored wood‐feeding insects, this Hypothesis paper discusses the broader phylogenetic context and potential adaptations necessary for this dietary specialization. The study proposes the “Detritivore‐First Hypothesis,” suggesting an evolutionary pathway to saproxylophagy through detritivory, and highlights the critical role of symbiotic gut microbiomes in the digestion of decaying wood.
Advancing the understanding of sustainable business models through organizational learning
Authors: Ademi Bejtush , Sætre Alf Steinar , Klungseth Nora Johanne 
Published: March 2024

AbstractIncreased regulations and shifting consumer priorities are driving businesses to become more sustainable and to develop more sustainable business models. To achieve this, businesses must have a solid understanding of sustainability. Organizational learning (OL) is a key capability that helps firms understand and adapt to new phenomena such as sustainability. We explore the nexus between OL and sustainability by examining how organizations learn about the latter. We employ an embedded case study approach, conducting 49 interviews and collecting over 1,000 pages of archival data. Our findings reveal concrete learning mechanisms that enhance understanding of sustainability and sustainable business models, including knowledge creation/acquisition, retention, and transfer, in business practices. Our study provides scholars and business practitioners with a detailed framework to guide the operationalization of OL to gain sustainability knowledge.
Network Pharmacology Approach to Identify the Calotropis Phytoconstituents’ Potential Epileptic Targets and Evaluation of Molecular Docking, MD Simulation, and MM‐PBSA Performance
Authors: Salaria Punam , Reddy M Amarendar 
Published: March 2024

AbstractEpilepsy originates from unusual electrical rhythm within brain cells, causes seizures. Calotropis species have been utilized to treat a wide spectrum of ailments since antiquity. Despite chemical and biological investigations, there have been minimal studies on their anticonvulsant activity, and the molecular targets of this plant constituents are unexplored. This study aimed to investigate the plausible epileptic targets of Calotropis phytoconstituents through network pharmacology, and to evaluate their binding strength and stability with the identified targets. In detail, 125 phytoconstituents of the Calotropis plant (C. procera and C. gigantea) were assessed for their drug‐likeness (DL), blood‐brain‐barrier (BBB) permeability and oral bioavailability (OB). Network analysis revealed that targets PTGS2 and PPAR‐γ were ranked first and fourth, respectively, among the top ten hub genes significantly linked with antiepileptic drug targets. Additionally, docking, molecular dynamic (MD) simulation, and Molecular Mechanics‐Poisson‐Boltzmann Surface Area (MM‐PBSA) were employed to validate the compound‐gene interactions. Docking studies suggested ergost‐5‐en‐3‐ol, stigmasterol and β‐sitosterol exhibit stronger binding affinity and favorable interactions than co‐crystallized ligands with both the targets. Furthermore, both MD simulations and MM‐PBSA calculations substantiated the docking results. Combined data revealed that Calotropis phytoconstituents ergost‐5‐en‐3‐ol, stigmasterol, and β‐sitosterol might be the best inhibitors of both PTGS2 and PPAR‐γ.
Investigating the Potential of Phenolic Compounds and Carbohydrates as Acceptor Substrates for Levansucrase‐Catalyzed Transfructosylation Reaction**
Authors: Wong Min Muriel , Liu Lan , Karboune Salwa 
Published: March 2024

AbstractThis study characterizes the acceptor specificity of levansucrases (LSs) from Gluconobacter oxydans (LS1), Vibrio natriegens (LS2), Novosphingobium aromaticivorans (LS3), and Paraburkholderia graminis (LS4) using sucrose as fructosyl donor and selected phenolic compounds and carbohydrates as acceptors. Overall, V. natriegens LS2 proved to be the best biocatalyst for the transfructosylation of phenolic compounds. More than one fructosyl unit could be attached to fructosylated phenolic compounds. The transfructosylation of epicatechin by P. graminis LS4 resulted in the most diversified products, with up to five fructosyl units transferred. In addition to the LS source, the acceptor specificity of LS towards phenolic compounds and their transfructosylation products were found to greatly depend on their chemical structure: the number of phenolic rings, the reactivity of hydroxyl groups and the presence of aliphatic chains or methoxy groups. Similarly, for carbohydrates, the transfructosylation yield was dependent on both the LS source and the acceptor type. The highest yield of fructosylated‐trisaccharides was Erlose from the transfructosylation of maltose catalyzed by LS2, with production reaching 200 g/L. LS2 was more selective towards the transfructosylation of phenolic compounds and carbohydrates, while reactions catalyzed by LS1, LS3 and LS4 also produced fructooligosaccharides. This study shows the high potential for the application of LSs in the glycosylation of phenolic compounds and carbohydrates.
Systemic lupus erythematosus associated with erythema multiforme: A rare case report of Rowell's syndrome
Authors: Bhattarai Madhur , Sharma Niraj Kumar , Paudel Shreeram , Bhandari Sujata , Bhusal Amrit , Dhonju Kiran , Kuikel Sandip , Jha Shivendra Kumar , Aryal Egesh , Subedi Deepak 
Published: March 2024

Key Clinical MessageAlthough it is very uncommon, SLE may initially present with recurrent episodes of EM‐like rash. Despite the various possibilities underlying their association, prompt identification, and treatment of SLE in patients presenting with EM is important to prevent death or serious organ damage.AbstractRowell's syndrome (RS) is an uncommon presentation of systemic lupus erythematosus (SLE) with erythema multiforme (EM)‐like lesions associated with specific serological changes, including positive rheumatoid factor (RF), speckled antinuclear antibody (ANA), positive rheumatoid factor, or anti‐La antibodies in the serum. Our case, a 41‐year‐old male, presented with features of EM. Upon investigation, we identified underlying systemic lupus erythematosus, marking a rare instance of SLE presenting for the first time as EM. Classical or true EM is precipitated by trigger factors such as infective agents like the herpes simplex virus, Mycoplasma pneumoniae, drugs like anticonvulsants, antibiotics, and non‐steroid anti‐inflammatory drugs, any underlying malignancy, or connective tissue disorders, and is not associated with any specific serological abnormalities. EM cases associated with LE lesions where an EM trigger factor is missing are considered an RS diagnostic criterion. In this case report, the importance of considering SLE in patients presenting initially with recurrent episodes of EM‐like rash is emphasized. RS should be considered, especially when there is no evidence of triggering factors. Early diagnosis and prompt treatment of SLE are crucial to preventing death and irreversible organ damage.
Challenging in leprosy relapse with antiphospholipid syndrome diagnosis: A case report
Authors: Kolahi Sousan , Ghadakchi Leyla , Jabbaripour Sarmadian Amirreza , Azimi Hamideh , Jafarpour Mehdi , Khalaji Amirreza 
Published: March 2024

Key Clinical MessageInfectious diseases like leprosy can cause antiphospholipid antibodies, leading to blood clots. Clinicians should consider this for patients with unusual thrombotic events and prior infectious disease history.AbstractThis case report details the diagnostic challenge of a 42‐year‐old man with a history of treated leprosy who presented with clinical features suggestive of antiphospholipid syndrome (APS). Vascular angiography revealed thrombosis, and serological tests were positive for APS antibodies. However, the patient subsequently developed symptoms, including thenar atrophy, paresthesia, and hypopigmented skin patches, which prompted further investigation. Electromyography detected sensorimotor polyneuropathy, while a nerve biopsy indicated a resurgence or chronic presence of leprosy. Despite initial APS management, the case evolved into a leprosy relapse confirmation after 20 years of remission, underscoring the diagnostic intricacies when concurrent autoimmune antibodies and infectious disease manifestations are present. This report emphasizes the importance of considering a broad differential diagnosis, including the potential for infectious disease relapse, in the presence of antiphospholipid antibodies. It illustrates the necessity of an interdisciplinary treatment approach in complex clinical scenarios.
A rare case of Fanconi anemia with Mitomycin C sensitivity: A pediatrics case report
Authors: Bhatt Vraj , Rohatgi Sunidhi , Singh Mansi 
Published: March 2024

Key Clinical MessageFanconi anemia with Mitomycin C sensitivity is a rare, complex hematological condition. Our case study emphasizes the significance of early diagnosis, appropriate genetic testing, and cautious use of chemotherapeutic agents.AbstractFanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure, congenital anomalies, and predisposition to cancer. Here, we present the case of a 6‐year‐old boy with a known diagnosis of Fanconi anemia who exhibited sensitivity to Mitomycin C. The patient had a history of recurrent blood transfusions due to anemia and was referred to our institution following worsening symptoms, including pallor, swelling in limbs, and respiratory distress. Physical examination revealed characteristic features of FA such as mesomelia, low‐set ears, hyperpigmented macules, microcephaly, micropthalmos, and thumb hypoplasia. Imaging studies demonstrated bilateral radial hypoplasia and congenital agenesis of the left kidney. Laboratory investigations revealed pancytopenia, aberrant liver function tests, and elevated inflammatory markers. Importantly, the patient exhibited sensitivity to Mitomycin C, highlighting the necessity for caution in selecting chemotherapeutic agents in FA patients. This case underscores the importance of early recognition, comprehensive evaluation, and tailored management strategies of patients with Fanconi anemia to optimize outcomes and minimize complications.
A case of relapsed acute myeloid leukemia mimicking acute otomastoiditis
Authors: Negara Ivan , Chemencedji Inga , Dobrovolschi Natalia , Sporis Natalia , Buruiana Sanda , Vinogradov Igor 
Published: March 2024

Key Clinical MessageIdentifying myeloid sarcoma in rare locations is a diagnostic challenge and requires careful evaluation. The optimal management of extramedullary disease requires further investigation, but tissue biopsy and a personalized approach are crucial.AbstractHerein, we describe an unusual case of acute myeloid leukemia presenting with an isolated involvement of the temporal bone after a complete remission of systemic disease for more than a year. The clinical, radiological, and pathological features are discussed, highlighting the importance of considering differential diagnoses and appropriate management.
Applications of Organosilanes in Visible Light‐induced Catalytic Asymmetric Reactions
Authors: Hou Liuzhen , Cao Weidi , Feng Xiaoming 
Published: March 2024

AbstractOver the past decades, visible light‐mediated photocatalysis has found a mainstream of applications in synthetic chemistry. Organosilanes have been proven to be a useful class of electron donors to generate the highly active radical species via photoinduced single electron transfer oxidation/fragmentation sequence, which may undergo follow‐up radical coupling or addition process. This minireview highlights the comprehensive advances of organosilanes in photoredox catalyzed asymmetric organic synthesis, with particular emphasis placed on reaction mechanisms. We hope that this review will inspire further design and development of new reactions with such class of readily accessible reagents.
FIRE DESIGN OF STEEL MEMBER BY COMPONENT‐BASED FINITE ELEMENT METHOD
Authors: Der Batuhan , Wald František , Vild Martin 
Published: March 2024

AbstractThe Component‐Based Finite Element Method (CBFEM) is the quite commonly used method to analyse and design connections of steel structures. It is the combination of the analytical component method and the numerical Finite Element Method (FEM). In this paper, the CBFEM is applied to analyse steel beams and columns at elevated temperature. The main objective of this study is to verify the CBFEM for predicting the resistance of steel members at elevated temperatures.
NUMERICAL CHARACTERIZATION OF INNOVATIVE DEMOUNTABLE BEAM‐COLUMN CONNECTIONS USING LONG BOLTS
Authors: Janković Neda , Dobrić Jelena , Gluhović Nina , Conde Jorge , Ljubinković Filip , da Silva Luís Simões 
Published: March 2024

AbstractCircular design strategies such as adaptivity, detachability, and reusability represent new challenges and increased demands on the future‐proof buildings sector. To contribute to the circularity and sustainability of the steel construction sector, an innovative solution of beam‐column moment‐resisting joints with long bolts and short steel elements (links) is proposed, enabling an extension in the service length of existing steel members. This paper assesses the influencing connection parameters (e.g. bolt preload, bolt length and diameter, end plate thickness, etc.) on the moment (flexural) resistance, stiffness, rotation, ductility, and failure modes of base configurations of these joints.