bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Peritoneal Packing Method for Management of Hyperkalemia During Acute Kidney Injury in Trauma
Authors: Zimmerman Eric M , Stewart Ian J , Graham Todd L , Kovacs Timothy J , Guliashvili Tamaz , Golobish Thomas D , Ross James D 
Published: February 2024

ABSTRACT

Introduction
United States Military operations in resource limited areas are increasing. Furthermore, future peer or near-peer conflicts will require caring for larger numbers of casualties with limited resources. In this setting, traditional renal replacement therapy is not feasible and novel methods are required to address severe acute kidney injury in austere environments lacking definitive therapies. Here, we describe experiments designed to determine the efficacy of a novel peritoneal packing material (Potassium Binding Pack-PBP, CytoSorbents INC) for the acute management of severe hyperkalemia.

Materials and Methods
Male swine (52 ±1 kg) were nephrectomized via midline laparotomy under a plane of anesthesia and randomized into one of two experimental groups (PBP & CON). Exogenous potassium was infused to achieve a serum potassium level of 7.5 mEq/L. Novel potassium absorbing packs (PBP) or sham packs (CON) were placed in the right and left upper quadrants, and the right and left paracolic gutters of the abdomen to simulate four-quadrant packing (n = 6, n = 5, respectively). Two liters of peritoneal dialysis fluid was instilled into the abdomen and temporary closure performed. Animals were observed for 12 hours. Serum and peritoneal fluid (dialysate) potassium levels were sampled at T = 15, 30, 60 min, and Q60min thereafter. Animals were humanely euthanized at the end of the observation period.

Results
Baseline characteristics were similar between groups. Pairwise analysis showed that serum potassium concentrations were significantly lower in the PBP group compared to CON at T = 540 and T = 720 (P = 0.006 and P = 0.015, respectively). Potassium concentrations were significantly lower in dialysate of the PBP group compared to CON at all time points after T = 15 (T = 30, P = 0.017; T = 60 through T = 720, P &lt; 0.001).

Conclusions
This is the first demonstration of an effective technology for the management of hyperkalemia in trauma in the absence of standard of care; renal replacement therapy. We identified that PBP was able to consistently maintain a concentration gradient between dialysate in the peritoneum and system potassium concentration throughout the experiment. Furthermore, systemic potassium concentrations were reduced in a clinically relevant manner in the PBP group compared to CON. This suggests that peritoneal packing technology for the management of metabolic disturbances in trauma has potential for clinical application. These results are preliminary and should be interpreted with caution.
An Augmented Reality Rifle Qualification Test for Return-to-Duty Assessment in Service Members
Authors: Kaya Ryan D , Hastilow Karissa , Owen Kelsey M , Zimmerman Eric M , Rosenfeldt Anson B , Alberts Jay L 
Published: February 2024

ABSTRACT

Introduction
Variability in return-to-duty (RTD) decision-making following mild traumatic brain injury (mTBI) is a threat to troop readiness. Current RTD assessments lack military-specific tasks and quantitative outcomes to inform stakeholders of a service member’s (SM) capacity to successfully perform military duties. Augmented reality (AR), which places digital assets in a user’s physical environment, provides a technological vehicle to deliver military-relevant tasks to a SM to be used in the RTD decision-making process. In addition to delivering digital content, AR headsets provide biomechanical data that can be used to assess the integrity of the central nervous system in movement control following mTBI. The objective of this study was to quantify cognitive and motor performance on an AR rifle qualification test (RQT) in a group of neurologically healthy military SMs.

Materials and Methods
Data were collected from 111 healthy SMs who completed a basic (single-task) and complex (dual-task) RQT with a simulated M4 rifle. The complex scenario required the SM to perform the RQT while simultaneously answering arithmetic problems. Position data from the AR headset were used to capture postural sway, and the built-in microphone gathered responses to the arithmetic problems.

Results
There were no differences in the number of targets hit, trigger pull reaction time, and transition time from kneeling to standing between the basic and complex scenarios. A significant worsening in postural sway following kneel-to-stand transition was observed in the complex scenario. The average reaction time to answer the arithmetic problems was nearly 2 times slower than the average reaction time to pull the trigger to a displayed target in the complex scenario.

Conclusion
The complex scenario provoked dual-task interference in SMs as evidenced by worsening postural sway and reaction time differences between the cognitive and motor tasks. An AR RQT provides objective and quantitative outcomes during a military-specific task. Greater precision in evaluating cognitive and motor performance during a military-relevant task has the potential to aid in the detection and management of SMs and their RTD following MTBI.
Real-time monitoring of mycelial growth in liquid culture using hyphal dispersion mutant of Aspergillus fumigatus
Authors: Miyazawa Ken , Umeyama Takashi , Takatsuka Shogo , Muraosa Yasunori , Hoshino Yasutaka , Yano Shigekazu , Abe Keietsu , Miyazaki Yoshitsugu 
Published: February 2024

Abstract
Hyphal pellet formation by Aspergillus species in liquid cultures is one of the main obstacles to high-throughput anti-Aspergillus reagent screening. We previously constructed a hyphal dispersion mutant of Aspergillus fumigatus by disrupting the genes encoding the primary cell wall α-1,3-glucan synthase Ags1 and putative galactosaminogalactan synthase Gtb3 (Δags1Δgtb3). Mycelial growth of the mutant in liquid cultures monitored by optical density was reproducible, and the dose-response of hyphal growth to antifungal agents has been quantified by optical density. However, Δags1Δgtb3 still forms hyphal pellets in some rich growth media. Here, we constructed a disruptant lacking all three α-1,3-glucan synthases and galactosaminogalactan synthase (Δags1Δags2Δags3Δgtb3), and confirmed that its hyphae were dispersed in all the media tested. We established an automatic method to monitor hyphal growth of the mutant in a 24-well plate shaken with a real-time plate reader. Dose-dependent growth suppression and unique growth responses to antifungal agents (voriconazole, amphotericin B, and micafungin) were clearly observed. A 96-well plate was also found to be useful for the evaluation of mycelial growth by optical density. Our method is potentially applicable to high-throughput screening for anti-Aspergillus agents.
Very blue-shifted broad Hα in a low-redshift type-1.9 active galactic nucleus: a disc-emitter or a recoiling black hole scenario?
Authors: Zhang Xue-Guang 
Published: February 2024

ABSTRACT
In this paper, very blue-shifted broad Hα with a shifted velocity of ∼2200 km s–1 is reported in the low-redshift type-1.9 active galactic nucleus (AGN) SDSS J1052+1036. Blue-shifted broad emission lines may arise owing to the presence of a rotating gas disc around a central black hole (BH), but may also be a signature of rare phenomena such as the gravitational wave recoil of a supermassive BH (rSMBH) or the presence of a binary BH (BBH) system. Here, owing to the higher shifted velocity of the stronger and wider blue-shifted broad Hα, the BBH system is disfavoured. Meanwhile, if this object contains a rSMBH, intrinsic obscuration with E(B –V) ≤ 0.6 should lead to a detectable broad Hβ, indicating that the rSMBH scenario is not preferred. We find that the blue-shifted broad Hα can be well explained by emission from an AGN disc, indicating that SDSS J1052+1036 is likely a disc-emitting AGN. In order to determine which scenario, a rSMBH or a disc-emitter, is preferred, a re-observed spectrum in 2025 could provide robust clues, with a disc-emitter probably leading to clear variations of peak positions, peak separations, and/or peak intensity ratios in broad Hα, but with a rSMBH scenario probably leading to no variations of peak separations in broad Hα.
The origin of lopsided satellite galaxy distribution around isolated systems in MillenniumTNG
Authors: Liu Yikai , Wang Peng , Guo Hong , Springel Volker , Bose Sownak , Pakmor Rüdiger , Hernquist Lars 
Published: February 2024

ABSTRACT
Dwarf satellites in galaxy groups are distributed in an anisotropic and asymmetric manner, which is called the ‘lopsided satellite distribution’. This lopsided signal has been observed not only in galaxy pairs but also in isolated systems. However, the physical origin of the lopsided signal in isolated systems is still unknown. In this work, we investigate this in the state-of-the-art hydrodynamical simulation of the MillenniumTNG Project by tracing each system back to high redshift. We find that the lopsided signal is dominated by satellites located in the outer regions of the halo and is also dominated by recently accreted satellites. The lopsided signal originates from the anisotropic accretion of galaxies from the surrounding large-scale structure and that, after accretion, the non-linear evolution of satellites inside the dark matter halo weakens the lopsidedness. The signal decreases as cosmic time passes because of a competition between anisotropic accretion and internal evolution within dark matter haloes. Our findings provide a useful perspective for the study of galaxy evolution, especially for the origin of the spatial satellite galaxy distributions.
Benchmarking the IRDC G351.77−0.53: Gaia DR3 distance, mass distribution, and star formation content
Authors: Reyes-Reyes S D , Stutz A M , Megeath S T , Xu Fengwei , Álvarez-Gutiérrez R H , Sandoval-Garrido N , Liu H -L 
Published: February 2024

ABSTRACT
While intensively studied, it remains unclear how the star formation (SF) in infrared dark clouds (IRDCs) compares to that of nearby clouds. We study G351.77-0.53 (henceforth G351), a cluster-forming filamentary IRDC. We begin by characterizing its young stellar object (YSO) content. Based on the average parallax of likely members, we obtain a Gaia distance of $\sim \, 2.0\pm 0.14$ kpc, resolving the literature distance ambiguity. Using our Herschel-derived N(H2) map, we measure a total gas mass of 10 200 M⊙ (within 11 pc2) and the average line-mass profile of the entire filament, which we model as $\lambda =~1660 (w/\rm pc)^{0.62}\, \, {\rm M}_{\odot }\, \rm {pc}^{-1}$. At w &lt; 0.63 pc, our λ profile is higher and has a steeper power-law index than λ profiles extracted in Orion A and most of its substructures. Based on the YSOs inside the filament area, we estimate the SF efficiency (SFE) and SF rate (SFR). We calculate a factor of 5 incompleteness correction for our YSO catalogue relative to Spitzer surveys of Orion A. The G351 SFE is ∼1.8 times lower than that of Orion A and lower than the median value for local clouds. We measure SFR and gas masses to estimate the efficiency per free-fall time, ϵff. We find that ϵff is ∼1.1 dex below the previously proposed mean local relation, and $\sim \, 4.7\times$ below Orion A. These observations indicate that local SF-relations do not capture variations present in the Galaxy. We speculate that cloud youth and/or magnetic fields might account for the G351 inefficiency.
Contribution of zinc accumulation to ischemic brain injury and its mechanisms about oxidative stress, inflammation, and autophagy: an update
Authors: Yang Xueqi , Li Wei , Ding Mao , Liu Ke Jian , Qi Zhifeng , Zhao Yongmei 
Published: February 2024

Abstract
Ischemic stroke is a leading cause of death and disability worldwide, and presently, there is no effective neuroprotective therapy. Zinc is an essential trace element that plays important physiological roles in the central nervous system. Free zinc concentration is tightly regulated by zinc-related proteins in the brain under normal conditions. Disruption of zinc homeostasis, however, has been found to play an important role in the mechanism of brain injury following ischemic stroke. A large of free zinc releases from storage sites after cerebral ischemia, which affects the functions and survival of nerve cells, including neurons, astrocytes, and microglia, resulting in cell death. Ischemia-triggered intracellular zinc accumulation also disrupts the function of blood–brain barrier via increasing its permeability, impairing endothelial cell function, and altering tight junction levels. Oxidative stress and neuroinflammation have been reported to be as major pathological mechanisms in cerebral ischemia/reperfusion injury. Studies have showed that the accumulation of intracellular free zinc could impair mitochondrial function to result in oxidative stress, and form a positive feedback loop between zinc accumulation and reactive oxygen species production, which leads to a series of harmful reactions. Meanwhile, elevated intracellular zinc leads to neuroinflammation. Recent studies also showed that autophagy is one of the important mechanisms of zinc toxicity after ischemic injury. Interrupting the accumulation of zinc will reduce cerebral ischemia injury and improve neurological outcomes. This review summarizes the role of zinc toxicity in cellular and tissue damage following cerebral ischemia, focusing on the mechanisms about oxidative stress, inflammation, and autophagy.
Beyond network centrality: individual-level behavioral traits for predicting information superspreaders in social media
Authors: Zhou Fang , Lü Linyuan , Liu Jianguo , Mariani Manuel Sebastian 
Published: February 2024

ABSTRACT
Understanding the heterogeneous role of individuals in large-scale information spreading is essential to manage online behavior as well as its potential offline consequences. To this end, most existing studies from diverse research domains focus on the disproportionate role played by highly connected ‘hub’ individuals. However, we demonstrate here that information superspreaders in online social media are best understood and predicted by simultaneously considering two individual-level behavioral traits: influence and susceptibility. Specifically, we derive a nonlinear network-based algorithm to quantify individuals’ influence and susceptibility from multiple spreading event data. By applying the algorithm to large-scale data from Twitter and Weibo, we demonstrate that individuals’ estimated influence and susceptibility scores enable predictions of future superspreaders above and beyond network centrality, and reveal new insights into the network positions of the superspreaders.
Infectious Diseases Physician Management of Cryptococcal Meningitis in North America—Is Single High-Dose Liposomal Amphotericin B Being Used?
Authors: Bahr Nathan C , Beekmann Susan E , Polgreen Philip M , Walker Jeremey B , Spec Andrej , Boulware David R , Baddley John W 
Published: February 2024

Abstract

Background
Several recent randomized trials have been conducted in resource-limited settings for cryptococcal meningitis that have rapidly innovated international guidelines. The 2010 Infectious Diseases Society of America (IDSA) cryptococcal meningitis guideline has not been updated with recent trials. The 2022 AMBITION-cm trial found that a single 10-mg/kg dose of liposomal amphotericin B plus daily flucytosine and fluconazole for 2 weeks was noninferior to 1 week of amphotericin B deoxycholate with flucytosine. It is unknown whether physicians in high-resource settings are using this regimen or more traditional regimens.

Methods
We developed an electronic survey in June 2023 to better understand whether physician members of the IDSA Emerging Infections Network (EIN) and Mycoses Study Group Education and Research Consortium (MSG-ERC) had used the AMBITION-cm induction regimen, would use the regimen in hypothetical clinical scenarios, and what perceived barriers to use existed.

Results
A total of 242 of 561 (43%) physicians responded to the survey, of whom 205 provided care for persons with cryptococcal meningitis in the last year. Overall, 29 (14%) had used the AMBITION-cm regimen, and 176 (86%) had not. In various hypothetical clinical scenarios, only ∼10% of 209 respondents selected the AMBITION-cm regimen as preferred. Perceived barriers to uptake included the applicability of trials performed in low-resource settings to high-resource settings, that the regimen is not recommended in the 2010 IDSA guidelines, and the applicability to persons without HIV.

Conclusions
Most respondents had not used the single-dose liposomal amphotericin B regimen, but the regimen is being used. Further study of this regimen in other patient populations and settings is necessary.
Discrimination in Multiphase Systems: Evidence from Child Protection
Authors: Baron E Jason , Doyle Joseph J , Emanuel Natalia , Hull Peter , Ryan Joseph 
Published: February 2024

Abstract
We develop empirical tools for studying discrimination in multiphase systems and apply them to the setting of foster care placement by child protective services. Leveraging the quasi-random assignment of two sets of decision-makers—initial hotline call screeners and subsequent investigators—we study how unwarranted racial disparities arise and propagate through this system. Using a sample of over 200,000 maltreatment allegations, we find that calls involving Black children are 55% more likely to result in foster care placement than calls involving white children with the same potential for future maltreatment in the home. Call screeners account for up to 19% of this unwarranted disparity, with the remainder due to investigators. Unwarranted disparity is concentrated in cases with potential for future maltreatment, suggesting that white children may be harmed by “underplacement” in high-risk situations.
Quantifying demand and willingness to pay for local food production
Authors: Ortez Mario , Thompson Taylor , Kilders Valerie , Widmar Nicole Olynk 
Published: February 2024

Abstract
The location of production and processing has had an increasingly prominent role in discussions regarding food systems today. Acknowledging the increasing importance, we study consumer preferences for and perception of local products with a particular focus on how willingness to pay (WTP) for local origin indication differs across products, types of designations, and rurality of the individual's geographic location. Using data collected through an online survey, we focused on Indiana residents’ preferences for sweet corn and Barbecue (BBQ) sauce with the sample representing both rural and urban consumers across all twelve economic growth regions in the state. Results reveal significant premiums for local products, with variations in WTP for certain local indications across rural and urban respondents. We also find that the marketing channel (farmer's market, direct from producer, or retail/grocery store) significantly influences respondents’ WTP for the two products, with results varying across the two products.
Can Italian forced heirship rights be enforced in England? Some remarks on the Del Curto decision
Authors: Panico Paolo 
Published: February 2024

Abstract
This case concerns the enforcement in England of a judgment where an Italian court ordered that the natural daughter of a deceased should receive a certain share of her father’s estate. It is not the assertion of a forced heirship entitlement but the application of Italian intestacy rules. The Master’s decision raises some questions as to the enforceability in England of an Italian judgment in a matter of succession. It is hoped that this will be clarified on appeal.
Almond hulls and shells as an alternative fiber source in limit-fed growing beef cattle diets
Authors: Duncan Zachary M , DeBord Zachary L , Pflughoeft Madison G , Suhr Kyler J , Hollenbeck William R , Brazle Frank K , Wecker Haley K , Paulk Chad B , Titgemeyer Evan C , Olson K C , Blasi Dale A 
Published: February 2024

Abstract
Almond hulls and shells are a by-product of almond production that can be incorporated as a feed ingredient in beef cattle diets. Three experiments were conducted to determine the effects of hammermill screen size on almond hull and shell bulk density and inclusion of ground or non-ground almond hulls and shells in limit-fed growing diets on growth performance, diet digestibility, and ruminal fermentation characteristics of beef cattle. In experiment 1, almond hulls and shells were ground with a laboratory-scale hammermill using no screen, a 11.1-mm screen, a 19.1-mm screen, or a 25.4-mm screen. Each screen-size treatment was ground at three separate time points (n= 3 replications/treatment). Grinding almond hulls and shells with no screen increased bulk density by 111% and minimized proportions of fine particles; therefore, almond hulls and shells ground using no screen were included as a treatment in the following experiments. In experiment 2, 364 steers (initial body weight [BW]: 257± 20.7 kg) were blocked by truckload (n = 4), stratified by BW, and assigned to pen within block. Pens were randomly assigned to 1 of 4 experimental diets (n= 10 pens/treatment). The control diet (CON) contained (DM basis) 39.5% dry-rolled corn, 7.5% supplement, 40% wet-corn gluten feed, and 13% prairie hay. Non-ground (13AH) or ground (13GAH) almond hulls and shells replaced prairie hay and were fed at 13% of diet DM or non-ground almond hulls and shells were fed at 26% of diet DM and replaced 13% prairie hay and 13% dry-rolled corn (26AH). Diets were limit-fed at 2.2% of BW daily (DM basis) for 56 d. Overall average daily gains (ADG) were greater (P ≤ 0.05) for CON, 13AH, and 13GAH compared with 26AH. In addition, ADG from days 14 to 56 were greater (P= 0.03) for 13GAH and tended to be greater (P = 0.09) for 13AH compared with CON. Experiment 3 was a 4 × 4 replicated Latin square in which 8 ruminally cannulated heifers (initial BW = 378 ± 44.0 kg) were fed diets from experiment 2. Apparent dry matter digestibility did not differ (P = 0.21) among treatments. Total ruminal volatile fatty acid concentrations were greater (P ≤ 0.03) for 13GAH and 13AH compared with 26AH and tended (P = 0.06) to be greater for 13GAH compared with CON. Overall, almond hulls and shells can be utilized as an alternative to prairie hay in limit-fed growing diets without negatively influencing rates of gain or diet digestibility.