bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zur Hydrolyse von 2,3‐Dihydro‐1,3‐di‐tert‐butyl‐4,5‐dimethylimidazol‐2‐yliden. Die Kristallstruktur von 1,3‐Di‐tert‐butyl‐4,5‐dimethylimidazoliumhydrogencarbonat
Authors: Abu‐Rayyan Ahmed , Abu‐Salem Qutaiba , Kuhn Norbert , Maichle‐Mößmer Cäcilia , Steimann Manfred , Henkel Gerald 
Published: March 2008

AbstractOn the Hydrolysis of 2,3‐Dihydro‐1,3‐di‐tert‐butyl‐4,5‐dimethylimidazol‐2‐ylidene. The Crystal Structure of 1,3‐Di‐tert‐butyl‐4,5‐dimethylimidazolium Bicarbonate1,3‐Di‐tert‐butyl‐4,5‐dimethylimidazolium bicarbonate (7), formed on the exposure of 2,3‐dihydro‐1,3‐di‐tert‐butyl‐4,5‐dimethylimidazol‐2‐ylidene (6) towards air, is prepared on the reaction of 6 with ammonium bicarbonate; its crystal structure analysis reveals the presence of dimeric bicarbonate anions linked to each other and to the imidazolium ions with hydrogen bonds.
Trans‐ and cis‐ Cobalt(III), Iron(III), and Chromium(III) Complexes Based on α‐ and γ‐Diimine Schiff Base Ligands: Synthesis and Evaluation of the Complexes as Catalysts for Oxidation of L‐Cysteine
Authors: Abu‐Surrah Adnan S. , Abdel‐Halim Hamzeh M. , Al‐Qaisi Feda'a M. 
Published: March 2008

AbstractThe synthesis of a new series of trans and racemic cis isomers of cobalt(III)‐, iron(III)‐, and chromium(III)‐based complexes with the α‐ and γ‐diimine Schiff base ligands, N,N′‐bis(X)‐2,3‐butandiimine and N,N′‐bis(X)‐1,2‐phenyldiimine (X = cyclohexyl, 2‐isopropylphenyl, 1‐naphthyl) is described. To confirm the identity of the complexes prepared in the present study, a variety of techniques including elemental analysis, magnetic susceptibility, infrared‐, mass‐ (EI), and UV/Vis‐ spectroscopy have been utilized. Some of the isolated complexes have been evaluated as catalysts for the oxidation of L‐cysteine. Preliminary results showed that the metal atoms, geometry of the complexes, auxiliary substituents, and the backbone of the ligand influenced the rate of oxidation reaction.
Evidence‐based Management of Toxic Multinodular Goiter (Plummer’s Disease)
Authors: Porterfield John R. , Thompson Geoffrey B. , Farley David R. , Grant Clive S. , Richards Melanie L. 
Published: March 2008

AbstractBackgroundToxic multinodular goiter (Plummer’s disease) has posed challenges to surgeons, endocrinologists, and radiation oncologists since its description in 1913. A literature review with evidenced‐based methodology has not yet been reported.MethodsA systematic review of the English literature from 1950 to 2007 and report of Mayo Clinic experience since 1950 was undertaken to establish evidence‐based recommendations for management.ResultsSurgery and radioactive iodine (RI) are both supported by level IV evidence in the treatment of solitary toxic nodules and toxic multinodular goiter, and treatment is determined by symptoms and co‐morbidities. No evidence suggests a difference in treatment outcome based on pretreatment clinical or subclinical hyperthyroidism. Level IV evidence supports thyroidectomy over RI for large goiters. When compressive symptoms are present, level IV evidence supports thyroidectomy for maximal symptom relief in patients at moderate risk. Occult malignancies are found in 2–3% of thyroidectomy specimens for Plummer’s disease. Despite technical reports of RI dose considerations, there are no prospective studies validating a dose formula. Ethanol ablation of toxic nodules in patients unfit for surgery is supported by level III evidence. Level V data suggest a cost benefit favoring surgery.ConclusionsTreatment of Plummer’s disease with antithyroid medications, ethanol ablation, RI ablation, or surgery must balance the goals of therapy, durability of cure, relief of symptoms, risk of malignancy, and risk of complications. Between 1950 and 2006, 948 (70%) of 1,356 patients with Plummer’s disease have been treated surgically at Mayo Clinic.
Velocity and temperature derivatives in high- Reynolds-number turbulent flows in the atmospheric surface layer. Part 3. Temperature and joint statistics of temperature and velocity derivatives
Authors: GULITSKI G. , KHOLMYANSKY M. , KINZELBACH W. , LÜTHI B. , TSINOBER A. , YORISH S. 
Published: March 2008

This is part 3 of our work describing experiments in which explicit information was obtained on all the derivatives, i.e. spatial derivatives, ∂/∂xj, and temporal derivatives, ∂/∂t, of velocity and temperature fields (and all the components of velocity fluctuations and temperature) at the Reynolds numberReλ~104.This part is devoted to the issues concerning temperature with the emphasis on joint statistics of temperature and velocity derivatives, based on preliminary results from a jet facility and the main results from a field experiment. Apart from a number of conventional results, these contain a variety of results concerning production of temperature gradients, such as role of vorticity and strain, eigen-contributions, geometrical statistics such as alignments of the temperature gradient and the eigenframe of the rate-of-strain tensor, tilting of the temperature gradient, comparison of the true production of the temperature gradient with its surrogate. Among the specific results of importance is the essential difference in the behaviour of the production of temperature gradients in regions dominated by vorticity and strain. Namely, the production of temperature gradients is much more intensive in regions dominated by strain, whereas production of temperature gradients is practically independent of the magnitude of vorticity. In contrast, vorticity and strain are contributing equally to the tilting of the vector of temperature gradients.The production of temperature gradients is mainly due to the fluctuative strain, the terms associated with mean fields are unimportant. It was checked directly (by looking at corresponding eigen-contributions and alignments), that the production of the temperature gradients is due to predominant compressing of fluid elements rather than stretching, which is true of other processes in turbulent flows, e.g. turbulent energy production in shear flows. Though the production of the temperature gradient and its surrogate possess similar univariate PDFs (which indicates the tendency to isotropy in small scales by this particular criterion), their joint PDF is not close to a bisector. This means that the true production of the temperature gradient is far from being fully represented by its surrogate. The main technical achievement is demonstrating the possibility of obtaining experimentally joint statistics of velocity and temperature gradients.
Influence of meteorological conditions on post-tonsillectomy haemorrhage
Authors: Racic G , Kurtovic D , Colovic Z , Dogas Z , Kardum G , Roje Z 
Published: March 2008

AbstractAim:To evaluate the relationship between the incidence of primary post-tonsillectomy haemorrhage and the daily weather condition, over a five-year period.Study design and setting:This was a retrospective study carried out in the ENT department of the Split University Hospital between January 2000 and December 2004.Results:Out of 3377 patients undergoing tonsillectomy, primary post-operative haemorrhage occurred in 83 (2.5 per cent). The season, daily atmospheric pressure and daily change in atmospheric pressure did not have any significant influence on post-tonsillectomy haemorrhage incidence. However, there was a statistically significant increase in the incidence of primary post-operative haemorrhage when cyclonic conditions prevailed (p = 0.035).Conclusion:The incidence of primary post-tonsillectomy haemorrhage in our study population was 2.5 per cent. Avoiding tonsillectomy during cyclonic weather conditions may reduce the incidence of primary post-tonsillectomy haemorrhage.
Imaging Epilepsy
Authors: Hermann Bruce P. 
Published: March 2008

Magnetic Resonance Imaging in Epilepsy: Neuroimaging
Techniques (2nd Edition). Rubin I. Kuzniecky and Graeme D. Jackson
(Eds.). 2005. New York: Elsevier. 431 pp., $149.95 (HB).Readers of JINS are aware that the epilepsies are common,
costly, and complex. Among the more common comorbidities are cognitive and
neuropsychiatric disorders. The potential etiologies of these disorders
include factors related to the cause, course, and treatment of the
epilepsy, which may exert their effects, at least in part, through
alterations in brain structure, metabolism, blood flow, and other
dimensions of brain integrity. These effects can be captured and
quantified by various neuroimaging techniques and greater familiarity with
the diversity of neuroimaging approaches to epilepsy may open a variety of
avenues of investigation.
Impact of food advertising on food purchases by students in primary and secondary schools in south-eastern Poland
Authors: Mazur A , Telega G , Kotowicz A , Małek H , Jarochowicz S , Gierczak B , Mazurkiewicz M , Pop T , Zajkiewicz K , Dobrucki M , Mazur D 
Published: March 2008

AbstractAimThe aim of the present study was to determine the impact of food advertising in primary and secondary schools on the food purchasing habits of children.MethodsAll forty-four primary and secondary schools in Rzeszow, Poland were included in the investigation; 15 000 children attend primary and secondary schools in the region. Schools were visited by members of the research team, who filled in a questionnaire regarding the type of food products displayed or advertised in the school shop window and recorded the presence of direct corporate advertising in the proximity of the school shop. Shop owners were asked to fill in a form describing food purchases by students within the week preceding the visit. The school principal (or one of teachers) completed a form describing the school’s policy regarding food advertising and the sponsorship of school activities by food companies.ResultsRecommended foods like milk, yoghurts and fruit were offered by only 40·9 % of shops. There was a correlation between foods offered in the shop and foods purchased by students. In schools, 40·9 % (95 % CI 25·8, 56·0 %) of shop windows displayed or advertised ‘healthy’ foods while 9·1 % (95 % CI 0·0, 17·9 %) of shops displayed advertisements of food companies. The difference between display of ‘healthy’ food in shop windows and display of food on company advertisements was significant (likelihood ratio χ2 test, P < 0·04). Type of school (primary v. secondary) was not significant factor in advertising or purchasing pattern.ConclusionsEducational programmes should be introduced in schools with the aim of improving the understanding of nutritional principles among pupils, teachers and parents.
Transmission dynamics and changing epidemiology of West Nile virus
Authors: Blitvich Bradley J. 
Published: March 2008

AbstractWest Nile virus (WNV) is a flavivirus that is maintained in a bird–mosquito transmission cycle. Humans, horses and other non-avian vertebrates are usually incidental hosts, but evidence is accumulating that this might not always be the case. Historically, WNV has been associated with asymptomatic infections and sporadic disease outbreaks in humans and horses in Africa, Europe, Asia and Australia. However, since 1994, the virus has caused frequent outbreaks of severe neuroinvasive disease in humans and horses in Europe and the Mediterranean Basin. In 1999, WNV underwent a dramatic expansion of its geographic range, and was reported for the first time in the Western Hemisphere during an outbreak of human and equine encephalitis in New York City. The outbreak was accompanied by extensive and unprecedented avian mortality. Since then, WNV has dispersed across the Western Hemisphere and is now found throughout the USA, Canada, Mexico and the Caribbean, and parts of Central and South America. WNV has been responsible for >27,000 human cases, >25,000 equine cases and hundreds of thousands of avian deaths in the USA but, surprisingly, there have been only sparse reports of WNV disease in vertebrates in the Caribbean and Latin America. This review summarizes our current understanding of WNV with particular emphasis on its transmission dynamics and changing epidemiology.
SWI-Prolog and the web
Authors: WIELEMAKER JAN , HUANG ZHISHENG , VAN DER MEIJ LOURENS 
Published: March 2008

AbstractProlog is an excellent tool for representing and manipulating data written in formal languages as well as natural language. Its safe semantics and automatic memory management make it a prime candidate for programming robust Web services. Although Prolog is commonly seen as a component in a Web application that is either embedded or communicates using a proprietary protocol, we propose an architecture where Prolog communicates to other components in a Web application using the standard HTTP protocol. By avoiding embedding in external Web servers, development and deployment become much easier. To support this architecture, in addition to the transfer protocol, we must also support parsing, representing and generating the key Web document types such as HTML, XML and RDF. This article motivates the design decisions in the libraries and extensions to Prolog for handling Web documents and protocols. The design has been guided by the requirement to handle large documents efficiently. The described libraries support a wide range of Web applications ranging from HTML and XML documents to Semantic Web RDF processing. The benefits of using Prolog for Web-related tasks are illustrated using three case studies.
Phylogenetic and functional gene analysis of the bacterial and archaeal communities associated with the surface microlayer of an estuary
Authors: Cunliffe Michael , Schäfer Hendrik , Harrison Emma , Cleave Simon , Upstill-Goddard Robert , Murrell J Colin 
Published: March 2008

Abstract
The surface microlayer (SML) is the thin biogenic film found at the surface of a water body. The SML is poorly understood but has been shown to be important in biogeochemical cycling and sea–air gas exchange. We sampled the SML of the Blyth estuary at two sites (salinities 21 and 31 psu) using 47 mm polycarbonate membranes. DNA was extracted from the SML and corresponding subsurface water (0.4 m depth) and microbial (bacteria and archaea) community analysis was performed using denaturing gradient gel electrophoresis of 16S rRNA gene PCR amplicons. The diversity of bacterial functional genes that encode enzyme subunits for methane monooxygenase (pmoA and mmoX) and carbon monoxide dehydrogenase (coxL) was assessed using PCR, clone library construction and restriction fragment length polymorphism (RFLP) analysis. Methanotroph genes were present only in low copy numbers and pmoA was detected only in subsurface samples. Diversity of mmoX genes was low and most of the clone sequences detected were similar to those of mmoX from Methylomonas spp. Interestingly, some sequences detected in the SML were different from those detected in the subsurface. RFLP analysis of coxL clone libraries indicated a high diversity of carbon monoxide (CO)-utilizing bacteria in the estuary. The habitats of the closely related coxL sequences suggest that CO-utilizing bacteria in the estuary are recruited from both marine and freshwater/terrestrial inputs. In contrast, methanotroph recruitment appears to occur solely from freshwater input into the estuary.
The immediate environment during postnatal development has long-term impact on gut community structure in pigs
Authors: Thompson Claire L , Wang Bing , Holmes Andrew J 
Published: March 2008

Abstract
The gastrointestinal tract of mammals contains a complex microbial community that influences numerous aspects of health and development. It is postulated that establishment of this community during early life has long-term consequences on the health status of adults. Potential influences on colonization are expected to include environmental microbes, diet and the developmental changes of the host. Denaturing gradient gel electrophoresis was used to follow the individual community dynamics of 24 piglets over the period of 3–36 days after birth. The community of piglets older than 31 days was inferred to show high stability relative to the first 28 days post birth. The stable day 36 community showed significant correlation between cohabiting piglets, but not between siblings. This cohabitation effect was not observable in 1- or 2-week-old piglets but was strongest at either 3 or 4 weeks post birth. The onset of this change after 2 weeks is predicted to be after the development of key induction elements of the immune system and before significant levels of piglet sIgA were observable (4 weeks). The outcome is altered community dynamics that result in significant similarity between the stable communities that develop in cohabiting pigs. We conclude that for a finite period in their development, the outcome of gut colonization in piglets is greatly influenced by the immediate environment. The implication is that mammals have a developmental window, in which the developing host–gut microbiota interaction will be simultaneously more amenable to engineering and more susceptible to disturbance.
Visceral Adiposity and Subclinical Coronary Artery Disease in Elderly Adults: Rancho Bernardo Study
Authors: Kim Dong‐Jun , Bergstrom Jaclyn , Barrett‐Connor Elizabeth , Laughlin Gail A. 
Published: March 2008

Objective: Despite growing attention to central obesity as a predictor of clinical coronary heart disease (CHD), there are few reports about the association between directly measured visceral obesity and subclinical coronary atherosclerosis in elderly adults. We examined this association in elderly, community‐dwelling adults without clinically recognized CHD.Methods and Procedures: Elderly adults (190 men, BMI 27.2 ± 3.6 kg/m2; 220 women, BMI 25.8 ± 4.6) aged 55–88 years (median 69 years) with no history of CHD or coronary revascularization had an electron beam computed tomography (EBCT) to measure coronary artery calcification score (CACS), an estimate of coronary plaque burden. Visceral and subcutaneous adiposity were assessed by a triple‐slice EBCT scan at the lumbar 4–5 disc level and height, weight, and waist and hip circumferences were measured.Results: In sex‐specific ordinal logistic regression analyses, no measure of obesity or body fat distribution, including BMI, waist‐to‐hip ratio, waist girth, and visceral and subcutaneous fat by EBCT, was significantly associated with CACS before or after adjusting for multiple covariates of CACS (age, smoking, alcohol intake, exercise, pulse pressure, low‐density lipoprotein (LDL)/high‐density lipoprotein (HDL)‐cholesterol ratio, and fasting plasma glucose).Discussion: In elderly adults without clinically recognized CHD, body weight and fat distribution do not predict coronary artery plaque burden. These results raise questions about the value of weight reduction diets for preventing heart disease in elderly survivors without clinical heart disease.
Common Variations in Perilipin Gene, Central Obesity, and Risk of Type 2 Diabetes in US Women
Authors: Qi Lu , Zhang Cuilin , Greenberg Andrew , Hu Frank B. 
Published: March 2008

Objective: The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity. We examined whether PLIN variability was associated with diabetes risk and obesity status modified such associations.Methods and Procedures: We conducted a nested case–control study of 431 incident cases of type 2 diabetes and 791 healthy control women from the Nurses' Health Study. Obesity was defined by BMI or waist circumference (central obesity).Results: In the sample of all participants, PLIN variations were not significantly associated with the incidence of diabetes. The central obesity status (by National Cholesterol Education Program Adult Treatment Panel III definition of waist circumference >35 inches) significantly interacted with PLIN polymorphisms in relation to diabetes risk (P for interaction = 0.027, 0.009, and 0.02 for rs2289487, rs8179043, and rs894160, respectively). In nonobese (central) women, carriers of rs2289487, rs8179043, and rs894160 had significantly greater risk of type 2 diabetes, adjusting for diabetes risk factors (odds ratio (OR) = 1.52, 1.03–2.25; 1.54, 1.07–2.23; and 1.57, 1.09–2.27, respectively). Haplotypes possessing the three polymorphisms were also significantly associated with diabetes risk (global test, P = 0.01). As compared with the most common haplotype 111, haplotype 222 and 211 (1 codes the common and 2 codes the minor alleles) were associated with 44% (OR = 1.44, 95% confidence interval (CI) 1.09–1.91; P = 0.01) and 70% (OR = 1.70, 95% CI 1.04–2.77; P = 0.03) greater risk, respectively. The PLIN variations were not significantly associated with the disease risk among women with central obesity.Discussion: Our data indicate that central obesity may modify the associations between PLIN variations and diabetes risk in women.
Resistance Training Conserves Fat‐free Mass and Resting Energy Expenditure Following Weight Loss
Authors: Hunter Gary R. , Byrne Nuala M. , Sirikul Bovorn , Fernández José R. , Zuckerman Paul A. , Darnell Betty E. , Gower Barbara A. 
Published: March 2008

Objective: To determine what effect diet‐induced ∼12 kg weight loss in combination with exercise training has on body composition and resting energy expenditure (REE) in premenopausal African‐American (AA) and European‐American (EA) women.Methods and Procedures: This study was a longitudinal, randomized weight loss clinical intervention, with either aerobic (AT), resistance (RT), or no exercise training (NT). Forty‐eight AA and forty‐six EA premenopausal overweight (BMI between 27 and 30) women underwent weight loss to a BMI <25. Body composition (densitometry), REE (indirect calorimetry), maximal oxygen uptake (VO2max), and muscular strength (isometric elbow flexion) were evaluated when subjects were in energy balance.Results: AA women lost less fat‐free mass (FFM, P ≤ 0.05) (47.0 ± 4.6 to 46.9 ± 5.0 kg) than EA women (46.4 ± 4.9 to 45.2 ± 4.6 kg). Regardless of race, RT maintained FFM (P ≤ 0.05) following weight loss (46.9 ± 5.2 to 47.2 ± 5.0 kg) whereas AT (45.4 ± 4.2 to 44.4 ± 4.1 kg) and NT (47.9 ± 4.7 to 46.4 ± 5.1 kg) decreased FFM (P ≤ 0.05). Both AT and NT decreased in REE with weight loss but RT did not. Significant time by group interactions (all P ≤ 0.05) for strength indicated that RT maintained strength and AT did not.Discussion: AA women lost less FFM than EA women during equivalent weight losses. However, following weight loss in both AA and EA, RT conserved FFM, REE, and strength fitness when compared to women who AT or did not train.