bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chondromyxoid fibroma: A fine‐needle aspiration diagnosis
Authors: Gupta S. , Dev G. , Marya S. 
Published: February 2007

AbstractA 25‐yr‐old female presented with a slowly progressive swelling, occurring over an 8‐yr period, in the right lower leg. The swelling was tender and fixed to the underlying bone. Clinical and radiological diagnosis was giant cell tumor (GCT) of the bone. Aspiration cytology smears were cellular showing an admixture of chondroid, stellate, and fibrocytic cells against a chondroid background. On cytomorphology, a diagnosis of chondromyxoid fibroma (CMF) was made. It was confirmed on histologic examination.
Fine‐needle aspiration of dermoid cyst of the pancreas: A case report
Authors: Markovsky Valentina , Russin Victoria L. 
Published: February 2007

AbstractA 53‐yr‐old woman presented with a left upper quadrant abdominal mass attached to the body of the pancreas. Fine‐needle aspiration (FNA) yielded cyst fluid containing numerous benign, mature squamous cells, keratin debris, and inflammatory cells. The diagnosis of dermoid cyst was subsequently rendered on the resected specimen. The cytologic and histologic features are presented. FNA cytology proves to be a valuable diagnostic adjunct in the preoperative evaluation of a patient with dermoid cyst of the pancreas.
Microglandular adenosis of the breast: Fine‐needle aspiration biopsy of two cases
Authors: Gherardi Giorgio , Bernardi Cinzia , Marveggio Cristina 
Published: February 2007

AbstractMicroglandular adenosis (MGA) recognizes a benign proliferative lesion of the breast that can mimic adenocarcinoma histologically. We describe the fine‐needle aspiration (FNA) biopsy cytology of MGA in two female patients. Smears were characterized by sparse cellularity, and the harvest consisted of a monotonous population of medium‐sized cells, with vacuolated clear cytoplasm and round and uniform nuclei with small nucleoli. Clear cells appeared isolated or clustered with spindly fibroblasts. No naked nuclei of myoepithelial origin were present in the background. The differential diagnostic considerations included several breast lesions composed of clear cells. Subsequent surgical histology of lumpectomy revealed MGA. Further studies are needed to determine whether these cytologic features permit the specific identification of MGA, but our observations show that FNA is a sensitive method in recognizing the benign nature of the lesion.
Cytology of allergic bronchopulmonary aspergillosis
Authors: Chen Karl T. K. 
Published: February 2007

AbstractThe cytologic features of a case of allergic bronchopulmonary aspergillosis (ABPA) are reported and the literature reviewed. The bronchial brushing smears in this case showed mucus that contained laminated aggregates of eosinophils with scattered Charcot‐Leyden crystals and fungal hyphae. These cytologic findings, overlooked by the initial examining pathologist, reflected the “mucoid impaction of bronchi” component of ABPA and are therefore diagnostic of ABPA. A cytologic diagnosis of a clinically unsuspected ABPA would lead to the correct treatment and prevent unnecessary surgery.
Skeletal structures that clinically simulate lymph nodes: Encounters during fine‐needle aspiration
Authors: Stanley Michael W. , Knoedler John P. 
Published: February 2007

AbstractWe report eight patients in whom bones of the cervical spine or cervical ribs were clinically mistaken for jugular chain or supra‐clavicular lymphadenopathy, respectively. Each was referred for fine‐needle aspiration by an experienced surgeon, oncologist, rheumatologist, or otolaryngologist. In the neck, the bony nature of the pseudo‐lymph nodes was apparent when the needle contacted bone. Bone was not contacted by the needle in the supra‐clavicular fossa. Aspiration smears showed normal soft tissues in all cases. Radiographs showed cervical ribs in both of the patients with supraclavicular pseudo‐lymphadenopathy. One of these was surgically explored and no adenopathy was detected. Radiographically, one patient with jugular chain findings had unilateral enlargement of a transverse vertebral bone process, another showed scoliosis, and a third had a normal cervical spine study. During follow‐up of 1‐33 mo (median = 14 mo), no patient developed adenopathy at any additional site. All are alive and well.
Respiratory cytology: A review of non‐neoplastic mimics of malignancy
Authors: Naryshkin Sonya , Young Nancy A. 
Published: February 2007

AbstractRespiratory cytology has its share of pitfalls. Some, such as vegetable cell contaminants, pose problems for only inexperienced observers, while others, such as reactive bronchoalveolar cells from pneumonia, can lead even experienced cytopathologists to make a misdiagnosis of malignancy. This review illustrates and analyzes those benign conditions or entities known to mimic malignancy in exfoliative respiratory cytology and fine‐needle aspiration biopsy of the lung. Entities are grouped by the type of malignancy they mimic, and guidelines are presented for avoiding specific pitfalls.
Fine‐needle aspiration of the breast: A review of 1,995 cases with emphasis on diagnostic pitfalls
Authors: Sneige Nour 
Published: February 2007

AbstractBetween 1985 to 1989, 1, 95 fine‐needle aspirations of palpable breast lesions were performed at our institution. In all cases, the aspirates were procured by cytopathologists using 22‐ or 23‐gauge needles. Direct smears were immediately stained with Diff‐Quik and Papanicolaou and assessed for specimen adequacy (criteria as followed in this institution). Tissue follow‐up was available in 1,117 cases. The cytologic diagnoses rendered in these cases were: malignant, 690 cases (60.2%); suspicious for carcinoma, 49 cases (4.3%); benign, 343 cases (29.9%), and insufficient specimen, 35 cases (3.1%). There were 28 false‐negative and 2 false‐positive results. Considering only cases definitively diagnosed as benign or malignant, the sensitivity was 96%, specificity 99%, positive predictive value 99%, negative predictive value 94%, and overall efficiency 97%. Of those specimens considered suspicious, only 11 cases (22%) were proved not to be malignant after excisional biopsy. These were three fibroadenomas, three ductal hyperplasias, two adenosis tumors, two mucocele‐like lesions, and one nipple adenoma. The two lesions that resulted in true false‐positive diagnoses were an apocrine cyst with atypia and sclerosing adenosis with radial scar. The clinical and cytologic features of the benign conditions that resulted in false suspicious and positive diagnoses and those features that distinguish them from carcinoma are presented.
Cytobrush sampling in conjunctival cytology
Authors: Anagnostopoulou‐Fotinopoulou Irene , Rammou‐Kinia Rea 
Published: February 2007

AbstractThe cervical cytobrush was used to obtain samples from the temporal bulbar conjunctiva of normal and nonnormal eyes in 54 cases after application of local anesthesia. The cotton swab was also used. All samples were smeared on glass slides, fixed immediately and then stained by a routine Papanicolaou method. On microscopic examination plenty of well preserved cells were present in all smears sampled by the cervical cytobrush. On the contrary, all samples obtained by the cotton swab contained few cells, most of which showed degeneration. The cervical cytobrush is very useful to conjunctival cytology because it provides abundant cellular material and good cell preservation, using standard and simple preparatory methods.
Thyroid tumors: Cytomorphology of hürthle cell tumors, including an uncommon papillary variant
Authors: Kaur Arvind , Jayaram Gita 
Published: February 2007

AbstractOf 2,012 fine‐needle aspirations (FNA) performed by us between 1984 and 1988, we present a detailed cytomorphologic analysis of 95 cases that were diagnosed as neoplastic on histology and/or cytology and those that received an equivocal cytodiagnosis. Discussed are eight tumors, which include three classic and five variant forms of Hürthle cell carcinoma. The latter showed a papillary tumor populated wholly by Hürthle cells, which we have morphologically designated as papillary Hürthle cell carcinoma. All three Hürthle cell carcinomas (PHC) were diagnosed on FNA as papillary Hürthle cell neoplasms (PHN). One was a false negative cytodiagnosis.
Quality‐assurance study of simultaneously sampled, non‐correlating cervical cytology and biopsies
Authors: Dodd Leslie G. , Sneige Nour , Villarreal Yolanda , Fanning Christina V. , Staerkel Gregg A. , Caraway Nancy P. , Silva Elvio G. , Katz Ruth L. 
Published: February 2007

AbstractAs part of a quality assurance study, we reviewed 223 cases of simultaneously sampled cervical smears and biopsies that showed a significant lack of correlation for squamous dysplasia or carcinoma. In 153 of the 223 cases (68.6%), the cytology was negative and the biopsy positive. After review of the specimens, errors in this group were found to be of the following types: sampling 64%, interpretive 29%, and combined sampling and interpretive 7%. In the remaining 70 cases (31.4%), the biopsy was negative and the Papanicolaou smear positive. In these cases, the following types of errors occurred: sampling 54%, interpretive 33%, and combination 13%. Twenty‐nine of these 70 patients showed dysplasia on follow‐up material. These findings indicate there are a significant number of false‐negative Papanicolaou smears, mostly because of sampling problems. There are few false‐positives. In cases of positive Papanicolaou and negative biopsy, dysplasia is likely to be present in subsequent samples.
Transplant aspirative cytology: Analysis of morphological and immunocytochemical parameters in renal allograft dysfunction
Authors: Castro C. Garcia , Gonzalez‐Posada J. M. , Lopez‐Tarruella V. Castro , Ruiz E. C. Salido 
Published: February 2007

AbstractWe have analyzed 245 transplant aspirative cytologies (TACs) from 96 renal allograft patients. TACs were divided in two chronological groups: Early (TACs performed during the first 3‐mo post‐transplantation) and late (TACs performed after the third month post‐transplantation), in order to assess the effect of allograft tolerance on TAC features. Both morphological and immunocytochemical aspects were evaluated, including CD4, CD8, IL2‐R, and HLA‐DR immunolabeling. A final diagnosis for each case of allograft dysfunction was achieved by other independent diagnostic means. Four diagnostic groups were considered in the present study: acute rejection (AR), chronic rejection (CR), acute tubular necrosis (ATN), and Cyclosporin A toxicity (CsA‐T). In addition, a control group (C) was established from patients with stable allograft function. We found that immunocytochemical analysis of TACs is particularly helpful in the diagnosis of late allograft dysfunction, a time period when the simple cytological study of renal infiltrate is not informative enough to help take therapeutic decisions.
Adenomyoepithelioma of the breast: Fine‐needle sampling with histologic, immunohistologic, and electron microscopic analysis
Authors: Vielh Philippe , Thiery Jean Paul , Validire Pierre , Maublanc Marie Annick , Woto Gisèle 
Published: February 2007

AbstractFine‐needle sampling was performed in a woman with a subareolar breast mass. The cytologic diagnosis was consistent with a benign sweat gland‐type tumor. Cytologic features included epithelial cells and spindle‐shaped cells lying free or in fibrillary myxoid ground substance. Histologic study revealed the biphasic appearance of this tumor composed of proliferating myoepithelial cells and glandular epithelial cells as supported by immunohistologic and electron microscopic analyses. Epithelial cells were strongly positive for cytokeratins, and spindle cells were positive for actin, S‐100 protein, and keratin and showed ultrastructurally typical features of myoepithelial cells.
Chondrosarcoma of bone as second tumor after diffuse anaplastic wilms' tumor:
Authors: Drut Ricardo , Pollono Daniel 
Published: February 2007

AbstractA 6‐yr‐old boy already treated (surgery and chemotherapy) for a diffuse anaplastic Wilms' tumor discovered at the age of 10 mo, presented with a large tumor in the left femur. This proved to be a chondrosarcoma after fine‐needle aspiration cytology, a diagnosis later confirmed by histology of the tumor. The patient was treated with marginal excision and prothetic replacement but died 1 yr after this operation with lung metastasis. It is proposed that this case may represent a new association of unusual types of tumors.
Immunophenotyping of cytologic specimens by flow cytometry
Authors: Moriarty Ann T. , Wiersema Lisa , Snyder Will , Kotylo Patricia K. , McCloskey Donald W. 
Published: February 2007

AbstractImmunophenotyping by flow cytometry is well established as an ancillary technique in the diagnosis of hematopoietic neoplasms. However, flow cytometry is rarely performed on cytologic specimens because most cytologists are more comfortable with direct microscopy and believe that there is inadequate cellularity for analysis. Paradoxically, cytologic material is usually cell suspensions making it ideal for flow cytometry. In order to evaluate the usefulness of immunophenotyping cytologic specimens by flow cytometry, we retrospectively reviewed all cytologic specimens submitted to our flow cytometry unit from 1988 to 1991. Thirty‐one cerebrospinal fluid specimens were analyzed. There were inadequate cells for analysis in 15 cases. Five showed a monoclonal proliferation; 11 were nondiagnostic. A range (r) of one to six cell surface markers were performed. Thirty‐two body cavity fluids were analyzed: 7 peritoneal, 19 pleural, 2 pericardial, and 4 bronchoalveolar lavage. There were cells to analyze in all cases. Seven had a monoclonal proliferation; 25 were nondiagnostic (r = 4‐21 markers performed). One hundred eighteen fine needle aspirates (FNA) were reviewed; 58 FNA were radiologically guided, 60 were superficial lesions. There were inadequate cells for analysis in two cases. Sixty‐one demonstrated a monoclonal proliferation; 55 were nondiagnostic (r = 1‐22 markers performed). We conclude that immunophenotyping by flow cytometry is of limited value for cerebrospinal fluid analysis and that knowledge of previous immunophenotyping studies is essential for correct analysis; analysis of body cavity fluids is easily performed but less often demonstrates a monoclonal proliferation. Immunophenotyping by flow cytometry is a valuable adjunctive technique for FNA and yields adequate cells for analysis.
Comparison of two techniques (flow cytometry and alkaline immunophosphatase) in the evaluation of alveolar macrophage immunophenotype
Authors: Pérez‐Arellano J. L. , Losa‐Garcia J. E. , Orfao‐Matos A. , González M. , De La Cruz J. L. , Jiménez A. , de Castro S. 
Published: February 2007

AbstractThe alveolar macrophage (AM) plays an essential role in the pathogenesis of interstitial lung diseases. The expression of specific membrane antigens is related to the functional or madurative status of the cells of mononuclear phagocyte system. The aim of this study was to analyze the expression of several markers (HLA‐DR, CD11b, CD16, CD14) in AM obtained by bronchoalveolar lavage from control patients (n = 6), patients with sarcoidosis (n = 6), diffuse neoplastic infiltration of the lung (n = 7), pulmonary fibrosis (n = 4), and hypersensitivity pneumonitis (n = 3) by two evaluation techniques (flow cytometry and alkaline immunophosphatase). In the light of the results we can conclude that in the immunophenotypical study of the alveolar macrophage, flow cytometry (with semiquantitative evaluation to avoid the problem of autofluorescence) is a useful tool in the evaluation of those antigens that are only weakly or moderately expressed on AM (CD11b or CD14), whereas the alkaline immunophosphatase technique is of great interest in the evaluation of those that are strongly expressed (i.e., HLA DR). Additionally, the variable expression of the different antigens in the different alveolar‐interstitial pathological states is patent in some diseases.
Cytology of pericardial effusions in aids patients
Authors: Zakowski Maureen F. , Lanuale‐Shanerman Angela 
Published: February 2007

AbstractPericardial effusions in patients with the acquired immunodeficiency syndrome (AIDS) can be due to a variety of causes and are often large enough to be sampled for cytologic examination. Over a period of 46 months, 15 cytologic specimens from 14 patients with AIDS were examined. Thirteen patients were male, one was female; the age range was 26 to 43 years. All male patients were homosexual or intravenous drug abusers, and the female patient was the spouse of an intravenous drug abuser. In general, the cytology specimens were moderately cellular with inflammatory cells seen in all cases. Atypical or reactive mesothelial cells were found in 12 cases (80%), and the atypia in one of these 12 was so marked that carcinoma was suspected; cells suspicious for malignant lymphoma were found in 2 cases (13%); degenerated mesothelial cells were present in one case. No infections were identified in this series. Ten patients (66%) had subsequent pericardial biopsies. Marked cellularity and nuclear pleomorphism in lymphoid cells with an altered nuclear cytoplasmic ratio were the dominant findings in the two suspected lymphoma cases. Both patients had known lymphoma elsewhere; in one, involvement by lymphoma was also found on pericardial biopsy. Mesothelial proliferations showing papillary formations with psammoma bodies were seen in three cases; in one of these, histoplasmosis was later diagnosed by pericardial biopsy. To our knowledge this is the first series to describe cytologically the marked mesothelial atypia seen in pericardial fluid in AIDS patients. We contrast this atypia with that seen in malignant effusions and caution against overinterpretation of pericardial fluids from AIDS patients.
Spindling artifact of urothelial cells in post‐laser treatment urinary cytology
Authors: Fanning Christina V. , Staerkel Gregg A. , Sneige Nour , Thomsen Sharon , Myhre Michael J. , von Eschenbach Andrew C. 
Published: February 2007

AbstractWe reviewed 22 post‐laser (Nd:YAG laser) coagulation bladder washes collected immediately after treatment. All washes demonstrated a striking artifact of cellular spindling. These spindled cells occurred singly, in loose clusters, and in lamellar stacks and had elongated nuclei with dense chromatin and bipolar cytoplasm that was fused in the stacks. Concurrent biopsies demonstrated similar cytologic changes. The spindling is a nonspecific epithelial response to heat. Conventionally electrocauterized epithelia show this artifact in biopsies, but since only the base of the lesion and surrounding urothelium are subjected to heat with electrocautery, the relatively few spindled epithelial cells created presumably go undetected in cytology specimens. With laser treatment, however, the whole urothelial surface of the lesion is coagulated, producing a much greater number of spindled cells. It is important to avoid misinterpreting the spindled cells as cells from a mesenchymal neoplasm or a sarcomatoid carcinoma, mistakes that were made in some of our initial cases. Malignancy cannot be evaluated when cells exhibit spindling artifact; this judgement should be made on undistorted cells. Thus, pre‐laser and post‐laser washes should be submitted for evaluation of malignancy.
Salivary monomorphic adenomas of dermal analogue type: Report of two cases
Authors: Sparrow Susan A. , Frost Felicity A. 
Published: February 2007

AbstractTwo cases of monomorphic adenoma, dermal analogue type, are presented illustrating fine‐needle aspiration cytology and subsequent histopathology. Aspiration findings were similar in both cases, demonstrating aggregates of mildly disorganised small regular epithelial cells bordered by a thick rim of basement membrane material. In the first case seen, there was a prominent lymphoid component which gave rise to the false suspicion that the lesion was lymphoepithelial in nature. The cytological features of this tumour are characteristic, however, and their recognition is important to enable distinction from malignancy (e.g., adenoid cystic carcinoma), other benign neoplasms (e.g., pleomorphic adenoma), and non‐neoplastic conditions.
Fine‐needle aspiration cytology of sclerosing hemangioma of the lung: Case report with immunohistochemical study
Authors: Wojcik Eva M. , Sneige Nour , Lawrence David D. , Ordóñez Nelson G. 
Published: February 2007

AbstractSclerosing hemangioma of the lung (SHL) is a rare benign neoplasm, usually found incidentally on a routine chest X‐ray. We present a case of SHL initially diagnosed by fine‐needle aspiration cytology. Cytomorphologic characteristics were confirmed by a cell block examination and immunohistochemical findings. The differential diagnoses of the fine‐needle aspiration are discussed.
Malignant cystic epithelial‐stromal tumor of the prostate
Authors: Hessel R. Glenn , Reyes Cesar V. , Jensen Joanne , Bayer Robert , Chinoy Mumtaz , Bhoophalam Nirmala 
Published: February 2007

AbstractA huge cystic tumor in the pelvis of a 62‐year old man, cytologically by fine needle aspiration biopsy, was composed of malignant spindle cells and transitional as well as glandular epithelial cells. Histochemical, immunostaining, and ultrastructural studies of the aspirated specimens and on the radically resected tumor indicated that the neoplastic cells are of prostatic fibroleiomyomatous stromal and epithelial origin. The lesion did not extend to the urothelium of the urinary bladder. This tumor resembles the rare cystadenoleiomyofibroma of the prostate, yet the cytologic abnormalities suggest a malignant potential. Long‐term follow‐up and recognition of additional cases are necessary to define the biologic behavior of this neoplasm.
Negative images of mycobacteria in aspiration biopsy smears from the lymph node of a patient with acquired immunodeficiency syndrome (AIDS): Report of a case and a review of the literature
Authors: Ang Grace A. T. , Janda William M. , Novak Richard M. , Gerardo Leo 
Published: February 2007

AbstractNegative images of acid‐fast bacilli were observed in Diff‐Quik‐stained smears of lymph node aspirates from a patient with acquired immunodeficiency syndrome (AIDS) and disseminated Mycobacterium avium‐intracellulare infection. The significance of this finding in relation to the diagnosis and treatment of this infection is discussed and the literature pertaining to this observation is reviewed.