bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temples as centres of communal networks: a case study of South Lantau
Authors: Cheung Sidney C. H. , Wong Alex W. H. 
Published: March 2024

AbstractIn the countryside, where intensive rural development and rising property values have been observed since the late 1970s, the preservation and meaning of traditional dwellings have emerged as crucial considerations in shaping Hong Kong’s countryside conservation policy. The focus of this paper is on the conservation of temples, as we are drawn to these structures not only for their architectural merit but also for their role as public buildings within the countryside. Consequently, their cultural significance is heavily influenced by the stakeholders they are associated with, distinguishing them from other types of dwellings.This paper examines the coastal landscape of South Lantau, which includes several villages with distinct traditions that have undergone significant transformations since the 1960s. Located at the southwest edge of Hong Kong, Lantau Island had a rural lifestyle that was relatively undisturbed before WWII because of the difficulty in accessing the island. However, in response to the large people influx from China's mainland after 1949, the Hong Kong government introduced the Lantau Development Plan in 1953, mainly to open up new sources of freshwater resources for Hong Kong Island. The construction of South Lantau Road in 1955 and Shek Pik Reservoir in 1957 gradually led to the decline of agricultural activities in South Lantau and the population exodus of local villagers, resulting in a rupture to regional traditions.In multilineage communities such as the villages on South Lantau, worship of a common deity provides a vital source of social bonding, particularly for an area long beset by typhoons, piracy and banditry. Local people pray for safety and prosperity through collective rituals and celebratory activities. Therefore, temples are not only religious establishments but also embody the sense of social solidarity among villagers on South Lantau. Through the case study of three rural villages on South Lantau, this paper examines how temples play an important role in the continuity of the communal network amid repercussions from the postwar disruption of traditional rural life. Significantly, this pilot study also draws attention to the functions of temples in their historical context. It emphasises the importance of recognising and re-evaluating these buildings for cultural enhancement as part of community engagement. This study provides valuable insights for future conservation efforts for religious buildings in the countryside.
Care Coordination Between Family Physicians and Palliative Care Physicians for Patients With Cancer: Results of a Quality Improvement Initiative
Authors: Cheon Stephanie , Tam Jonathan , Herx Leonie , Nowak Justyna , Goldie Craig , Kain Danielle , Iqbal Majid , Sinnarajah Aynharan , Mathews Jean 
Published: March 2024

PURPOSE At our institution's cancer palliative care (PC) clinic, new referrals from oncologists were scheduled for consultation and ongoing follow-up by PC physicians without input from the patients' family physicians (FPs). FPs reported that they felt out of the loop. We implemented a quality improvement (QI) initiative aimed at systematically facilitating care coordination between FPs and PC physicians. METHODS A coordination toolkit was sent from the PC physician to the FP whenever the PC physician received a consultation request from an oncologist. The toolkit included an introduction to the PC physician team; an opportunity for the FP to choose how best to collaborate with PC physicians to meet the patient's PC needs; and contact information for access to 24/7 PC physician support. Responses from FPs regarding their preferred level of engagement with PC determined further care planning in the clinic. We measured feasibility, response rate, and qualitative surveys of FPs about the usefulness of the intervention. RESULTS Two hundred fourteen new consultations were eligible for a standardized letter over the 6-month implementation period. Feasibility for sending the toolkit was 90.0% and response rate for collaborative care preference from FPs was 86.0%, with median response time of 3-4 days. 78.9% of FPs indicated they would prefer ongoing consultative care by the PC physician, while 18.6% indicated that PC physician consultation was not needed, or that the FP would provide primary PC after a one-time PC physician consultation. CONCLUSION We successfully implemented a QI initiative to improve care coordination between FPs and PC physicians for patients with cancer. The coordination toolkit can protect the patient-FP primary PC relationship and optimize specialist PC resource utilization for complex patients.
The Formal Demography of Peak Population
Authors: Goldstein Joshua R. , Cassidy Thomas 
Published: March 2024

Abstract
When will the human population peak? In this article, we build on classical results by Ansley Coale, who showed that when fertility declines steadily, births reach their maximum before fertility reaches replacement level, and the decline in total population size does not occur until several decades after fertility has reached that level. We extend Coale's results by modeling longevity increases, net immigration, and a slowdown in fertility decline that resembles current projections. With these extensions, our models predict a typical lag between replacement-level fertility and population decline of about 35 to 40 years, consistent with projections by the United Nations and about 15 years longer than the lag predicted by Coale. Our analysis helps reveal underlying factors in the timing of peak population.
F-box protein FBXB-65 regulates anterograde transport of the kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain
Authors: Sabharwal Vidur , Boyanapalli Sri Padma Priya , Shee Amir , Nonet Michael L. , Nandi Amitabha , Chaudhuri Debasish , Koushika Sandhya P. 
Published: March 2024

ABSTRACT
Axonal transport in neurons is essential for cargo movement between the cell body and synapses. Caenorhabditis elegans UNC-104 and its homolog KIF1A are kinesin-3 motors that anterogradely transport precursors of synaptic vesicles (pre-SVs) and are degraded at synapses. However, in C. elegans, touch neuron-specific knockdown of the E1 ubiquitin-activating enzyme, uba-1, leads to UNC-104 accumulation at neuronal ends and synapses. Here, we performed an RNAi screen and identified that depletion of fbxb-65, which encodes an F-box protein, leads to UNC-104 accumulation at neuronal distal ends, and alters UNC-104 net anterograde movement and levels of UNC-104 on cargo without changing synaptic UNC-104 levels. Split fluorescence reconstitution showed that UNC-104 and FBXB-65 interact throughout the neuron. Our theoretical model suggests that UNC-104 might exhibit cooperative cargo binding that is regulated by FBXB-65. FBXB-65 regulates an unidentified post-translational modification (PTM) of UNC-104 in a region beside the cargo-binding PH domain. Both fbxb-65 and UNC-104, independently of FBXB-65, regulate axonal pre-SV distribution, transport of pre-SVs at branch points and organismal lifespan. FBXB-65 regulates a PTM of UNC-104 and the number of motors on the cargo surface, which can fine-tune cargo transport to the synapse.
Photoreceptor calyceal processes accompany the developing outer segment, adopting a stable length despite a dynamic core
Authors: Sharkova Maria , Aparicio Gonzalo , Mouzaaber Constantin , Zolessi Flavio R. , Hocking Jennifer C. 
Published: March 2024

ABSTRACT
Vertebrate photoreceptors detect light through a large cilium-based outer segment, which is filled with photopigment-laden membranous discs. Surrounding the base of the outer segment are microvilli-like calyceal processes (CPs). Although CP disruption has been associated with altered outer segment morphology and photoreceptor degeneration, the role of the CPs remains elusive. Here, we used zebrafish as a model to characterize CPs. We quantified CP parameters and report a strong disparity in outer segment coverage between photoreceptor subtypes. CP length is stable across light and dark conditions, yet heat-shock inducible expression of tagged actin revealed rapid turnover of the CP actin core. Detailed imaging of the embryonic retina uncovered substantial remodeling of the developing photoreceptor apical surface, including a transition from dynamic tangential processes to vertically oriented CPs immediately prior to outer segment formation. Remarkably, we also found a direct connection between apical extensions of the Müller glia and retinal pigment epithelium, arranged as bundles around the ultraviolet sensitive cones. In summary, our data characterize the structure, development and surrounding environment of photoreceptor microvilli in the zebrafish retina.
Producing Hardwood Cross-Laminated Timber (HCLT) Mats from Low-Grade Red Oak Lumber
Authors: Norris Jonathan R. , Hassler Curt C. , Denes Levente , Oporto Gloria , Bencsik Balazs , McNeel Joseph F. 
Published: March 2024

Abstract
The use of cross-laminated timber (CLT) has significantly grown in North America, but hardwood species have not yet been deemed a viable raw material for manufacturing CLT panels. Therefore, softwood species continue to serve as the only approved material for CLT in structural applications according to ANSI/APA PRG-320. Nonstructural CLT products that utilize low-grade lumber from hardwood species, are a good option for introducing hardwoods into the CLT market.
Of the hardwood species located within Appalachia, northern red oak (Quercus rubra) is readily available. The purpose of this research was to develop hardwood cross-laminated timber mats utilizing low-grade red oak lumber. In order to manufacture red oak CLT mats, the best adhesive and bonding parameters had to be identified. Overall, sample CLT panels were made using three adhesives with nine different setups for each adhesive. The sample panels were processed into smaller blocks and separated for cyclic delamination and shear-block tests following the ANSI/APA PRG-320 standards.
This research determined that a phenol–resorcinol formaldehyde (PRF) adhesive produced the lowest percentage of delamination, satisfying the delamination requirements. The PRF adhesive also produced the largest percentage of wood failure in shear-block testing, however, the results fell short of meeting the requirements. A Taguchi statistical analysis was used to predict the optimal bonding parameters for each adhesive. The optimized bonding parameters for the polyurethane (PUR) adhesive produced favorable results, indicating the delamination results have the potential to nearly meet the standard requirements, while the predicted shear results would exceed the requirements.
Community’s knowledge, perceptions and preventive practices on Onchocerciasis in Jimma zone, Ethiopia, formative mixed study
Authors: Abdissa Daba , Kebede Yohannes , Sudhakar Morankar , Abraham Gelila , Bulcha Gebeyehu , Shiferaw Teshome , Berhanu Nimona , Teshome Firanbon , Miecha Hirpa , Birhanu Zewdie 
Published: March 2024

Background
In Ethiopia, Onchocerciasis is a prevalent neglected tropical disease, currently targeted for elimination with mass drug administration and community behavioral changes towards sustained control and eventual elimination. This study aimed to elucidate the awareness, perceptions and practices of endemic communities in Jimma Zone, Ethiopia.

Methods and materials
Community-based cross-sectional study triangulated with qualitative method was conducted from October-November, 2021. A multistage sampling was employed and data were collected using a pre-tested interviewer-administered structured questionnaire. Logistic regression was used to identify the predictors of comprehensive knowledge and preventive practice. Adjusted odds ratios were calculated at 95% confidence interval (CI) and considered significant with a p-value of <0.05. Kruskal-Whallis and Mann-whitney tests were used to compare median risk perception score by socio-demographic factors. Qualitative data were collected through focus group discussions and key informant interviews and transcribed verbatim. Then the data were coded, categorized, and themes were developed.

Result
The overall prevalence of adequate comprehensive knowledge was 48.8% (95% CI: 44.9, 52.3), high risk perception was 18.7% (95%CI15.9, 21.4) and preventive practice was 46.9%(95%CI:(43.3,50.4). High risk perception[AOR = 1.95 95%CI: (1.32, 2.89] was statistically significant with comprehensive knowledge, likewise knowledge of mode of transmission [AOR = 2.64 95% CI: (1.44, 4.85)], knowledge of consequences [AOR = 2.12 95%CI: (1.21, 3.72)] and knowledge of preventive measures [AOR = 15.65,95%CI:(10.1, 24.2)] were statistically significant with preventive practice. The median risk perception was varied significantly between the groups by educational status, study district and age category. Qualitative evidence showed that there were great community knowledge gap about the disease.

Conclusion
Community knowledge, perceptions, and practices are unacceptably low. Risk perception was significantly associated with comprehensive knowledge, likewise knowledge of mode of transmission, consequences and preventive measures were significantly associated with preventive practice. This implies knowledge is a key component of effective prevention strategies as it is a necessary condition for the behavior change.
Survival and prognostic factors in pediatric osteosarcoma: A 5-year single-center experience in Central Java, Indonesia
Authors: Riza Muhammad , Salimo Harsono , Wasita Brian , Idulhaq Mujaddid , Saputra Rhyan Darma , Widyaningsih Vitri , Soestrisno Soestrisno , Zahidah Fairuz , Wayanshakty Janur 
Published: March 2024

Background The advent of chemotherapy with multimodal treatment has improved the survival rate of osteosarcoma. However, the survival rate of patients with osteosarcoma in low- and middle-income countries (LMICs) remains lower than in high-income countries (HICs).
Objective To assess prognostic factors associated with survival rate of pediatric patients with osteosarcoma in Moewardi Hospital, Surakarta.
Methods This retrospective study was performed in pediatric osteosarcoma patients at Moewardi Hospital, Surakarta from 2018 to 2022. We described patients’ clinical presentations and assessed prognostic factors. Survival rate was calculated using Kaplan–Meier survival analysis. Prognostic factors were analyzed using univariate and multivariate Cox regression methods.
Results Of the 82 patients included in the study, 40 (48.8%) were male and 42 (51.2%) were female. Most subjects (75.6%) were diagnosed with osteosarcoma at the age of >10 years, 45 patients (54.9%) had primary tumors in the femur, and 16 patients (19.5%) had limb salvage surgery. The mean event-free survival duration was 13.6 (95%CI 9.7 to 17.5) months. The mean duration of overall survival was 22.7 (95%CI 17.3 to 28.1) months, with a 44.1% survival probability. Type of surgery was a significant prognostic factor (P=0.018), with limb salvage having better survival probability (93.3%) than amputation (19.8%).
Conclusion The overall survival rate of osteosarcoma patients at our center is still lower than in other regional centers. Limb salvage surgery was a significant prognostic factor for survival, while gender, location of primary tumor, histological subtype, and metastasis at the time of diagnosis were not.
Shared medical appointments and quality of life for children with HIV-AIDS
Authors: Perdani Roro Rukmi Windi , Farishal Ahmad , Wardani Amanda Saphira 
Published: March 2024

Background The human immunodeficiency virus (HIV) infects immune cells and weakens the immune system. There are 36.9 million HIV sufferers worldwide, with 1.8 million of them being children. Children with HIV and their parents may benefit from focus group discussions, also known as shared medical appointments (SMAs). SMAs represent an educational method capable of enhancing the quality of healthcare services. However, this method remains relatively under-researched in HIV/AIDS patients.
Objective To assess the impact of SMA on the quality of life of children with HIV-AIDS.
Methods This quasi-experimental study with a cross-sectional approach was carried out for 2 months. Subjects participated in SMAs, accompanied by a pediatrician as facilitator. Subjects filled three Pediatric Quality of Life (PedsQL) questionnaires (Inventory 4.0, General Well-Being Scale 3.0, and Healthcare Satisfaction 3.0), before and after attending SMAs. We compared the results.
Results There were 12 respondents, with the majority aged 5-10 years (50%), and a higher proportion of male than female (33.3%). The majority of boys had stage 3 HIV, while most girls had stage 2 HIV. According to the PedsQL Inventory module, the average quality of life for the physical aspect was the highest (83), while the lowest was observed in the school aspect (45). In the General Well-being module, the average emotional health scores were 84 before and 93 after SMAs, which were higher than the overall health scores (68 and 77 before and after SMAs, respectively). In the Healthcare Satisfaction module, the lowest average scores were in family satisfaction (52 before and 64 after SMAs), whereas the highest were in satisfaction with healthcare provider treatment (87 and 81 before and after SMAs, respectively). There was a significant increase before and after the SMAs in emotional health (P=0.009).
Conclusion An improvement in emotional health was observed based on the General Well-being module of the PedsQL before and after SMAs intervention. Thus, SMAs may potentially improve the quality of life for children with HIV-AIDS.
Risk factors contributing to weaning failure from continuous positive airway pressure to high flow nasal cannula in neonates with respiratory distress syndrome
Authors: Putra Najih Rama Eka , Dadiyanto Dwi Wastoro , Sahyuni Riza , Rini Arsita Eka , Muryawan Heru , Suswihardhyono Adhie Nur Radityo 
Published: March 2024

Background Respiratory distress syndrome (RDS) is one of the most frequent causes of mortality and morbidity in neonates. High flow nasal canule (HFNC) is a step ladder modality of alternative oxygen therapy for weaning to reduce the workload of breathing and the need for intubation.
Objective To identify the risk factors contributing to weaning failure from continuous positive airway pressure (CPAP) to HFNC in neonates with RDS.
Methods This study was a retrospective observational study in neonates aged less than 36 weeks weighing less than 2500 grams who underwent CPAP to HFNC weaning from 2019 to 2021 in Dr. Kariadi Hospital, Semarang, Central Java, Indonesia.
Results There were 108 patients included in this study. Our bivariate analysis found significant differences in gestational age, age at the start of weaning, body weight at the start of weaning, FiO2 levels, history of maternal chorioamnionitis, patent ductus arteriosus (PDA), anemia, apnea of prematurity (AOP), and sepsis in neonates with RDS. Multivariate analysis showed that the most dominant factors were FiO2 levels of more than 25% at the start of weaning (OR11.16; 95%CI 1.83 to 63.12; P=0.009), anemia (OR 7.70; 95%CI 1.39 to 42.67; P=0.019), AOP (OR 19.64; 95%CI 4.27 to 90.35; P<0.001), and sepsis (OR 10.93; 95%CI 2.37 to 45.53; P=0.002)
Conclusion FiO2 setting of more than 25% at the start of weaning, anemia, AOP, and sepsis produce a significant probability of HFNC weaning failure.
Diagnostic Efficacy of a Novel Rotating Brush for Endoscopic Sampling of Malignant Biliary Strictures: A Multicenter Prospective Study
Authors: Xia Mingxing , Shen Zhenyang , Zheng Haiming , Yuan Lin , Hu Jiangfeng , Zhao Yi , Zhou Dongxun , Bai Xianghui , Wang Junjun , Li Xiaoman , Dai Weiming , Kang Mei , Zhou Hui , Wan Rong , Lu Lungen , Hu Bing , Wan Xinjian , Cai Xiaobo 
Published: March 2024

INTRODUCTION:Although cytologic examination of biliary stricture brushings obtained by endoscopic retrograde cholangiopancreatography is commonly used for diagnosing malignant biliary strictures (MBSs), it has low sensitivity. Several new brushes have capabilities that are still being debated. We have developed a novel brush working from conventional back-and-forth movement to rotationin situ(RIS) that may be more efficient for MBS sampling. We aimed to compare the MBS detection sensitivity of our RIS brush with that of the conventional brush.METHODS:In this multicenter prospective study, we enrolled patients who underwent endoscopic retrograde cholangiopancreatography for suspected MBSs involving biliary stricture brushings obtained using our RIS brush. The historical control group consisted of the 30-brushing arm of our previous randomized trial (patient inclusion, 2018–2020) that used the study design in the same centers and with the same endoscopists as were used in this study. The primary outcome was to compare the sensitivity and specificity of detecting MBSs by cytologic evaluation of biliary stricture brushings between the 2 groups.RESULTS:We enrolled 155 patients in the intent-to-treat analysis. Using the same number of brushing cycles, the RIS brush showed a higher sensitivity than the conventional brush (0.73 vs 0.56,P= 0.003). In per-protocol population, the sensitivity was also higher in the RIS brush group than in the conventional brush group (0.75 vs 0.57,P= 0.002). Multivariate analysis revealed that the RIS brush was the only predictive factor for MBS detection. No significant differences were observed in procedure-related complications between the 2 groups.DISCUSSION:The RIS brush was a promising tool for effective and safe MBS sampling and diagnosis. Further randomized studies are warranted to confirm our results (Chictr.org.cn, identifier: ChiCTR2100047270).
Global Dynamics and Optimal Policy in the Ak Model with Anticipated Future Consumption
Authors: Gomez Manuel A. 
Published: March 2024

Abstract
This paper analyzes the Ak model with anticipated future consumption. In the model with internal anticipation individual’s utility depends on current consumption and a forward-looking reference level which is formed from individual’s own future consumption. The global dynamics of the economy is characterized by means of a qualitative phase diagram analysis. In the model with external anticipation the consumption reference level is formed from economy-wide average future consumption, which is taken as given by individuals and causes the competitive equilibrium to be inefficient. Characterizing the global dynamics of the economy is required to characterize an optimal fiscal policy that corrects the inefficiency brought about by this external effect.