bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of the Zone of Proximal Development Concept (Scaffolding) on the Students Problem Solving Skills and Learning Outcomes
Authors: Raslan Gilan 
Published: March 2024

AbstractSchools regularly use the zone of proximal development (ZPD), also known as scaffolding, to help students learn new skills. Students who do not receive enough scaffolding may not be able to acquire the skills at all, while students who receive too much scaffolding may suffer when it is taken away. Additionally, this will have an impact on their capacity for problem-solving and learning outcomes. This systematic literature review's goal is to examine how ZPD and scaffolding effect students’ learning outcomes and the growth of their problem-solving abilities.Through a selection of pertinent publications that have undergone extensive analysis, the study addresses three main research topics.The study's findings revealed that in order to achieve a high level of learning independence for the students and the ability to adapt to new situations leading to more advanced skills, a re-definition of certain concepts along with modifications and amendments on how to apply these new redefined ones, using more advanced teaching methodologies with incorporating technology to help students in exploring new ideas using critical thinking techniques and providing constructive feedback, are needed.
Two body non-leptonic D0 decays from LCSR and implications for$${\Delta a}_{{\text{CP}}}^{{\text{dir}}}$$
Authors: Lenz Alexander , Piscopo Maria Laura , Rusov Aleksey V. 
Published: March 2024

Abstract
Motivated by the recent measurements of CP violating effects in singly Cabibbo suppressed D0 decays, we revisit the theoretical predictions of these channels. Using up-to-date values for the decay constants and form factors, we find already within naive QCD factorisation, surprisingly good agreement between the central values of the branching ratios and the corresponding experimental data. We further extend the study of these modes by employing the method of light-cone sum rules (LCSR) with light-meson light-cone distribution amplitudes. Using for the first time this framework to compute the leading contribution to the decay amplitude, we can again describe well the experimental branching ratios for the modes D0 → π+K−, D0 → K+K−, D0 → π+π− and D0 → K+π−. The combination of our results with known predictions for the penguin contributions obtained with LCSR, leads to an upper bound for the value of direct CP violation expected in the Standard Model of $$\left|{\Delta a}_{{\text{CP}}}^{{\text{dir}}}\right|\le 2.4\times {10}^{-4}$$, which is approximately a factor six smaller than the current measurement.
Cone holography with Neumann boundary conditions and brane-localized gauge fields
Authors: Cui Zheng-Quan , Guo Yu , Miao Rong-Xin 
Published: March 2024

Abstract
Cone holography is a codimension-n doubly holographic model, which can be interpreted as the holographic dual of edge modes on defects. The initial model of cone holography is based on mixed boundary conditions. This paper formulates cone holography with Neumann boundary conditions, where the brane-localized gauge fields play an essential role. Firstly, we illustrate the main ideas in an AdS4/CFT1 toy model. We show that the U(1) gauge field on the end-of-the-world brane can make the typical solution consistent with Neumann boundary conditions. Then, we generalize the discussions to general codimension-n cone holography by employing brane-localized p-form gauge fields. We also investigate perturbative solutions and prove the mass spectrum of Kaluza-Klein gravitons is non-negative. Furthermore, we prove that cone holography obeys holographic c-theorem. Finally, inspired by the recently proposed chiral model in AdS/BCFT, we construct another type of cone holography with Neumann boundary conditions by applying massive vector (Proca) fields on the end-of-the-world brane.
Superconformal indices for non-Lagrangian theories in five dimensions
Authors: Kim Hee-Cheol , Kim Minsung , Kim Sung-Soo , Zafrir Gabi 
Published: March 2024

Abstract
We propose two novel methods for computing the superconformal index of 5d superconformal field theories that cannot be described by conventional Lagrangian descriptions under mass deformations. The first approach involves the use of Higgs branch flows from UV Lagrangian theories, guided by transitions in 5-brane webs in Type IIB string theory. The second method employs the relationship between O7+-plane and O7−-plane with eight D7-branes, which applies to particular non-Lagrangian theories realized by brane configurations involving an O7+-plane. As a concrete application of our method, we compute the superconformal indices for all known rank-1 non-Lagrangian theories, which we also use to identify flavor symmetries and their global forms at the conformal field theory (CFT) fixed points.
Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury
Authors: Peng Xujun , Li Huiling , Zhang Wenbo , Zhang Dongshan 
Published: March 2024

AbstractApproximately 60% of septic patients developed acute kidney injury (AKI). The mortality rate of septic AKI (SA-AKI) is two to three times higher than that of septic without AKI (SA-non-AKI). The actual functions and mechanisms of CircRNAs in the pathophysiology of SA-AKI remain incompletely understood. Herein, we observed that the mmu_Circ_26986 could be induced by lipopolysaccharide (LPS) and cecum ligation and puncture (CLP) in BUMPT cell line and C57BL/6 mouse kidney, respectively. Functionally, mmu_Circ_26986 suppressed BUMPT cell apoptosis induced by LPS. Mechanistically, mmu_Circ_26986 sponged miRNA-29b-1-5p to upregulate the expression of PAK7. Overexpression of mmu_Circ_26986 ameliorated the progression of CLP-stimulated AKI through miRNA-29b-1-5p/PAK7 axis. In addition, we found that hsa_Circ_0072463, homologous to mmu_Circ_26986, suppressed LPS-induced HK-2 cells apoptosis via regulation of miRNA-29b-1-5p/PAK7 axis. Furthermore, sepsis patients with AKI had a higher level of hsa_Circ_0072463 compared to those without AKI. The sensitivity, specificity and AUC of hsa_Circ_0072463 were 78.8%, 87.9% and 0.866, respectively. Spearman's test indicated a noticeable positive correlation between plasma hsa_Circ_0072463 and serum creatinine in sepsis patients (r = 0.725). In summary, this study reveals that the mmu_Circ_26986/hsa_Circ_0072463 miRNA-29b-1-5p/PAK7 axis mediates septic AKI, and hsa_Circ_0072463 is a potential diagnostic marker for septic AKI.
Augmented Lagrangian Acceleration of Global-in-Time Pressure Schur Complement Solvers for Incompressible Oseen Equations
Authors: Lohmann Christoph , Turek Stefan 
Published: March 2024

AbstractThis work is focused on an accelerated global-in-time solution strategy for the Oseen equations, which highly exploits the augmented Lagrangian methodology to improve the convergence behavior of the Schur complement iteration. The main idea of the solution strategy is to block the individual linear systems of equations at each time step into a single all-at-once saddle point problem. By elimination of all velocity unknowns, the resulting implicitly defined equation can then be solved using a global-in-time pressure Schur complement (PSC) iteration. To accelerate the convergence behavior of this iterative scheme, the augmented Lagrangian approach is exploited by modifying the momentum equation for all time steps in a strongly consistent manner. While the introduced discrete grad-div stabilization does not modify the solution of the discretized Oseen equations, the quality of customized PSC preconditioners drastically improves and, hence, guarantees a rapid convergence. This strategy comes at the cost that the involved auxiliary problem for the velocity field becomes ill conditioned so that standard iterative solution strategies are no longer efficient. Therefore, a highly specialized multigrid solver based on modified intergrid transfer operators and an additive block preconditioner is extended to solution of the all-at-once problem. The potential of the proposed overall solution strategy is discussed in several numerical studies as they occur in commonly used linearization techniques for the incompressible Navier–Stokes equations.
Sarcopenia is associated with chemoradiotherapy discontinuation and reduced progression-free survival in glioblastoma patients
Authors: Troschel Fabian M. , Troschel Benjamin O. , Kloss Maren , Jost Johanna , Pepper Niklas B. , Völk-Troschel Amelie S. , Wiewrodt Rainer G. , Stummer Walter , Wiewrodt Dorothee , Eich Hans Theodor 
Published: March 2024

Abstract
Purpose
Sarcopenia may complicate treatment in cancer patients. Herein, we assessed whether sarcopenia measurements derived from radiation planning computed tomography (CT) were associated with complications and tumor progression during radiochemotherapy for glioblastoma.

Methods
Consecutive patients undergoing radiotherapy planning for glioblastoma between 2010 and 2021 were analyzed. Retrocervical muscle cross-sectional area (CSA) was measured via threshold-based semi-automated radiation planning CT analysis. Patients in the lowest sex-specific quartile of muscle measurements were defined as sarcopenic. We abstracted treatment characteristics and tumor progression from the medical records and performed uni- and multivariable time-to-event analyses.

Results
We included 363 patients in our cohort (41.6% female, median age 63 years, median time to progression 7.7 months). Sarcopenic patients were less likely to receive chemotherapy (p < 0.001) and more likely to be treated with hypofractionated radiotherapy (p = 0.005). Despite abbreviated treatment, they more often discontinued radiotherapy (p = 0.023) and were more frequently prescribed corticosteroids (p = 0.014). After treatment, they were more often transferred to inpatient palliative care treatment (p = 0.035). Finally, progression-free survival was substantially shorter in sarcopenic patients in univariable (median 5.1 vs. 8.4 months, p < 0.001) and multivariable modeling (hazard ratio 0.61 [confidence interval 0.46–0.81], p = 0.001).

Conclusion
Sarcopenia is a strong risk factor for treatment discontinuation and reduced progression-free survival in glioblastoma patients. We propose that sarcopenic patients should receive intensified supportive care during radiotherapy and during follow-up as well as expedited access to palliative care.
Design of metamaterial-based heat manipulators using isogeometric level-set topology optimization
Authors: Jansari Chintan , Bordas Stéphane P. A. , Atroshchenko Elena 
Published: March 2024

AbstractWe exploit level-set topology optimization to find the optimal material distribution for metamaterial-based heat manipulators. The level-set function, geometry, and solution field are parameterized using the Non-Uniform Rational B-Spline (NURBS) basis functions to take advantage of easy control of smoothness and continuity. In addition, NURBS approximations can produce conic geometries exactly and provide higher efficiency for higher-order elements. The values of the level-set function at the control points (called expansion coefficients) are utilized as design variables. For optimization, we use an advanced mathematical programming technique, Sequential Quadratic Programming. Taking into account a large number of design variables and the small number of constraints associated with our optimization problem, the adjoint method is utilized to calculate the required sensitivities with respect to the design variables. The efficiency and robustness of the proposed method are demonstrated by solving three numerical examples. We have also shown that the current method can handle different geometries and types of objective functions. In addition, regularization techniques such as Tikhonov regularization and volume regularization have been explored to reduce unnecessary complexity and increase the manufacturability of optimized topologies.
Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings
Authors: De Silva D. Thisuri N. , Petrovski Michael , Strunk Tobias , Mukadam Nabeelah , Page-Sharp Madhu , Moore Brioni R. , Batty Kevin T. 
Published: March 2024

Abstract
Purpose
To investigate the physicochemical compatibility of caffeine citrate and caffeine base injections with 43 secondary intravenous (IV) drugs used in Neonatal Intensive Care Unit (NICU) settings.

Methods
Caffeine citrate (20 mg/mL or 10 mg/mL) or caffeine base injection (10 mg/mL) were mixed in a volume ratio of 1:1 with the secondary drug solution to simulate Y-site co-administration procedures in NICUs. Physical compatibility was evaluated based on visual observation for 2 h, against a black and white background and under polarised light, for changes in colour, precipitation, haze and evolution of gas. Chemical compatibility was determined from caffeine concentration measurements, using a validated high-performance liquid chromatography assay.

Results
Six of the 43 secondary drugs tested (aciclovir, amphotericin (liposomal), furosemide, hydrocortisone, ibuprofen and ibuprofen lysine) were physically incompatible with caffeine citrate undiluted injection (20 mg/mL), at their high-end, clinically relevant concentrations for NICU settings. However, when tested at lower concentrations, hydrocortisone (1 mg/mL) was physicochemically compatible, whereas furosemide (0.2 mg/mL) was physically incompatible with caffeine citrate. The six drugs which showed physical incompatibility with caffeine citrate 20 mg/mL injection were also physically incompatible with caffeine citrate 10 mg/mL solution. All 43 secondary drugs tested were physicochemically compatible with caffeine base injection.

Conclusions
Most secondary test drugs, except aciclovir, amphotericin (liposomal), furosemide, hydrocortisone, ibuprofen and ibuprofen lysine, were physicochemically compatible with caffeine citrate injection. Caffeine base injection was physicochemically compatible with all 43 test drugs tested.
Berge equilibrium, altruism and social welfare
Authors: Haller Hans 
Published: March 2024

AbstractWelfare and other properties of Berge equilibria are investigated. In particular, we address the questions to what extent Berge equilibrium can select from multiple Nash equilibria; can serve as a substitute for Nash equilibria; can Pareto improve upon Nash equilibrium. Furthermore, some of the recent results on the relation between Berge equilibria and Kantian equilibria are summarized.
On the existence of stationary threshold bilinear processes
Authors: Ghezal Ahmed , Cavicchioli Maddalena , Zemmouri Imane 
Published: March 2024

AbstractThis article investigates some statistical and probabilistic properties of general threshold bilinear processes. Sufficient conditions for the existence of a causal, strictly and weak stationary solution for the equation defining a self-exciting threshold superdiagonal bilinear $$\left( SETBL\right) $$

S
E
T
B
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process are derived. Then it is shown that under well-specified hypotheses the higher-order moments of the SETBL process are finite. As a result, the skewness and kurtosis indexes are explicitly computed. The exact autocorrelation function is derived with an arbitrarily fixed number of regimes. Also, the covariance functions of the process and its powers are evaluated and the second (respectively, higher)-order structure is shown to be similar to that of a linear process. This implies that the considered process admits an ARMA representation. Finally, necessary and sufficient conditions for the invertibility and geometric ergodicity of a SETBL model are established. Some examples illustrate the obtained theoretical results.
Prosecuting cases of abusive head trauma in Switzerland: a descriptive study of the impact of medical documentation and delay of reporting on judicial outcome
Authors: Held Sarah , Cheseaux Jean-Jacques , Tolsa Jean-François , Depallens Sarah 
Published: March 2024

AbstractAbusive head trauma (AHT) is a criminal offence that is prosecuted ex officio, following report to the police from physicians or child protection services. The aim of this study was to assess whether the judicial outcome (dismissal vs indictment) was influenced by the quality of the medical documentation and/or the time span between AHT diagnosis and reporting child abuse to the police. The cohort was divided in two groups: 13/23 dismissals (57%) and 10/23 indictments (43%). The diagnostic probability of the AHT cases was certain for both groups. Nonetheless, in fraction of dismissed cases, alternative explanations for the observed lesions seemed plausible to the public prosecutor. Legal files of only 3/12 dismissed cases had a forensic report, while 6/10 cases that were indicted included a forensic report. Further, the legal file of several dismissed cases entirely lacked medical documentation (3/12), which was not the cases for indicted cases. The period between AHT diagnosis and reporting to the police was not different for dismissals (29 ± 19 days) and indictments (7 ± 4 days) (p = 0.32). Physicians filed reports more rapidly (6 ± 1 days) compared to childhood protection service (70 ± 46 days) (p = 0.01) and that may increase the rate of indictments (9/18) compared to reporting via the childhood protection service (1/5). Despite diagnostic certainty, other causes for the lesions were considered as plausible alternative explanations to judicial professionals in several dismissed cases. These seemed to have less medical documentation and forensic evaluations. In addition, more rapid reporting to the police by physicians seems to increase the likelihood of indictments.
Variants in mitochondrial disease genes are common causes of inherited peripheral neuropathies
Authors: Ferreira Tomas , Polavarapu Kiran , Olimpio Catarina , Paramonov Ida , Lochmüller Hanns , Horvath Rita 
Published: March 2024

Abstract
Background
Peripheral neuropathies in mitochondrial disease are caused by mutations in nuclear genes encoding mitochondrial proteins, or in the mitochondrial genome. Whole exome or genome sequencing enable parallel testing of nuclear and mtDNA genes, and it has significantly advanced the genetic diagnosis of inherited diseases. Despite this, approximately 40% of all Charcot-Marie-Tooth (CMT) cases remain undiagnosed.

Methods
The genome-phenome analysis platform (GPAP) in RD-Connect was utilised to create a cohort of 2087 patients with at least one Human Phenotype Ontology (HPO) term suggestive of a peripheral neuropathy, from a total of 10,935 patients. These patients’ genetic data were then analysed and searched for variants in known mitochondrial disease genes.

Results
A total of 1,379 rare variants were identified, 44 of which were included in this study as either reported pathogenic or likely causative in 42 patients from 36 families. The most common genes found to be likely causative for an autosomal dominant neuropathy were GDAP1 and GARS1. We also detected heterozygous likely pathogenic variants in DNA2, MFN2, DNM2, PDHA1, SDHA, and UCHL1. Biallelic variants in SACS, SPG7, GDAP1, C12orf65, UCHL1, NDUFS6, ETFDH and DARS2 and variants in the mitochondrial DNA (mtDNA)-encoded MT-ATP6 and MT-TK were also causative for mitochondrial CMT. Only 50% of these variants were already reported as solved in GPAP.

Conclusion
Variants in mitochondrial disease genes are frequent in patients with inherited peripheral neuropathies. Due to the clinical overlap between mitochondrial disease and CMT, agnostic exome or genome sequencing have better diagnostic yields than targeted gene panels.
Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress
Authors: Pálešová Nina , Bláhová Lucie , Janoš Tomáš , Řiháčková Katarína , Pindur Aleš , Šebejová Ludmila , Čupr Pavel 
Published: March 2024

Abstract
Introduction
Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well as widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs and associated health outcomes is limited.

Objective
We aimed to characterise exposure to BTs among Czech men, including possible occupational exposure among firefighters, its predictors, and its associations with liver function, serum lipids and oxidative stress.

Methods
165 participants (including 110 firefighters) provided urine and blood samples that were used to quantify the urinary levels of 8 BTs (high-performance liquid chromatography-tandem mass spectrometry), and 4 liver enzymes, cholesterol, low-density lipoprotein, and 8-hydroxy-2’-deoxyguanosine. Linear regression was used to assess associations with population characteristics and biomarkers of liver function, serum lipids and oxidative stress. Regression models were adjusted for potential confounding variables and false discovery rate procedure was applied to account for multiplicity.

Results
The BTs ranged from undetected up to 46.8 ng/mL. 2-hydroxy-benzothiazole was the most predominant compound (detection frequency 83%; median 1.95 ng/mL). 1-methyl-benzotriazole (1M-BTR) was measured in human samples for the first time, with a detection frequency 77% and median 1.75 ng/mL. Professional firefighters had lower urinary 1M-BTR compared to non-firefighters. Urinary 1M-BTR was associated with levels of γ-glutamyl transferase (β = − 17.54%; 95% CI: − 26.127, − 7.962).

Conclusion
This is the first study to investigate BT exposure in Central Europe, including potentially exposed firefighters. The findings showed a high prevalence of BTs in the study population, the relevance of 1M-BTR as a new biomarker of exposure, and an urgent need for further research into associated adverse health outcomes.

Graphical abstract
Durability of the moderate-to-heavy-intensity transition is related to the effects of prolonged exercise on severe-intensity performance
Authors: Hamilton Kate , Kilding Andrew E. , Plews Daniel J. , Mildenhall Mathew J. , Waldron Mark , Charoensap Thanchanok , Cox Tobias H. , Brick Matthew J. , Leigh Warren B. , Maunder Ed 
Published: March 2024

Abstract
Purpose
Power output at the moderate-to-heavy-intensity transition decreases during prolonged exercise, and resilience to this has been termed ‘durability’. The purpose of this study was to assess the relationship between durability and the effect of prolonged exercise on severe-intensity performance, and explore intramuscular correlates of durability.

Methods
On separate days, 13 well-trained cyclists and triathletes (V̇O2peak, 57.3 ± 4.8 mL kg−1 min−1; training volume, 12 ± 2.1 h week−1) undertook an incremental test and 5-min time trial (TT) to determine power output at the first ventilatory threshold (VT1) and severe-intensity performance, with and without 150-min of prior moderate-intensity cycling. A single resting vastus lateralis microbiopsy was obtained.

Results
Prolonged exercise reduced power output at VT1 (211 ± 40 vs. 198 ± 39 W, ∆ -13 ± 16 W, ∆ -6 ± 7%, P = 0.013) and 5-min TT performance (333 ± 75 vs. 302 ± 63 W, ∆ -31 ± 41 W, ∆ -9 ± 10%, P = 0.017). The reduction in 5-min TT performance was significantly associated with durability of VT1 (rs = 0.719, P = 0.007). Durability of VT1 was not related to vastus lateralis carnosine content, citrate synthase activity, or complex I activity (P > 0.05).

Conclusion
These data provide the first direct support that durability of the moderate-to-heavy-intensity transition is an important performance parameter, as more durable athletes exhibited smaller reductions in 5-min TT performance following prolonged exercise. We did not find relationships between durability and vastus lateralis carnosine content, citrate synthase activity, or complex I activity.