bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired stammering in Great Britain
Authors: Stewart Trudy , Rowley David 
Published: November 2007

ABSTRACTSThere are a growing number of reports of late onset of stammering from clinicians but a lack of data concerning the nature, aetiology and outcomes of therapy. This research attempts to replicate in Great Britain a survey of clinicians carried out in America. Clinicians completed a questionnaire on their clients with acquired stammering. Details on possible cause, speech and language characteristics, and therapeutic outcomes were compared with the American study. Results were similar in terms of aetiology and outcome measures despite reported differences in characteristics and treatment regimes offered.Il existe un nombre croissant de compte‐rendus médicaux sur les cas de débuts tardifs de bégaiement, mais les données font défaut quant à la nature, l'étiologie et les résultats de la thérapie. Cette étude a pour but de reproduire en Grande‐Bretagne une enquète sur les médecins déjà menée en Amérique. Les médecins ont rempli un questionnaire sur ceux de leurs clients qui s'étaient mis à souffrir de bégaiement. La comparison avec l'étude américaine a porté sur les causes possibles, les caractéristiques de langue et de discours, et les résultats de la thérapie. Les résultats sont semblables en ce qui concerne l'étiologie et les mesures finales, en dépit de différences relevées pour les caractéristiques et les régimes de traitments offerts.Es gibt eine wachsende Anzahl von kilinischen Berichten über spat einsetzendes Stammeln, aber es fehlen Daten über die Form, die Ätiologie und über die Folgen der Therapie. Diese Studie versucht, eine in den USA durchgeführte Umfrage bei klinischer Therapeuten in Großbritannien zu replizieren. Die Therapeuter beantworteten einen Fragebogen über ihre Patienten mit erworbenen Stammeln. Einzelheiten zur möglichen Ursache, Sprach‐ und Sprechcharakteristika sowie zum Erfolg der Therapie wurden mit der amerikanischen Studie verglichen. Die Ergebnisse waren trotz berichteter Unterschiede in der Form des Stammeins und in der angebotenen Behandlung hinsichtlich der errechneten Werte für die Ätiologie und für den Erfolg der Therapie ähnlich.
A content analysis of the professional journal of the British Society of Speech Therapists I: The first 10 years. Spotlight on ‘Speech’ 1935–1945
Authors: Armstrong Linda , Stansfield Jois 
Published: November 2007

ABSTRACTSThe 24 editions of the professional journal ‘Speech’ published between 1935–1945 were examined by use of content analysis. The use of this approach enabled an in‐depth survey of the professional, clinical and political issues of the period which saw the beginning of speech and language therapy as a profession. Two main areas were focused upon: the development of the professional body and the authored papers which appeared in the journal. ‘Speech’ at that time can be viewed as a blend of today's ‘European Journal of Disorders of Communication’ with today's ‘Bulletin’.Les 24 numéros de la revue professionnelle ‘Speech’ parus entre 1935 et 1945 ont été examinés au moyen d'une analyse de contenus. Cette méthode a fourni un relevé en profondeur des problèmes professionnels, cliniques et politiques de cette période témoin des débuts de l'orthophonie en tant que profession. Deux domaines ont reçu tout particulièrement notre attention: le développement de l'effectif de la profession, et les articles signés qui ont paru dans la revue. L'on peut dire qu'à cette époque ‘Speech’ correspondait à la fois à ce que sont aujourd'hui le ‘European Journal of Disorders of Communication’ et le ‘Bulletin’.Die 24 Ausgaben der Fachzeitschrift ‘Speech’, die zwischen 1935–1945 erschienen sind, wurden mit Hilfe der Inhaltsanalyse untersucht. Dieser methodische Ansatz ermöglichte einen gründlichen Überblick über die beruflichen, klinischen und politischen Fragen jener Zeit, in der die Sprachtherapie als Berufsstand ihren Anfang hatte. Zwei Hauptbereiche wurden näher beleuchtet: Die Entwicklung der Berufsgruppe und die in der Zeitschrift erschienenen Aufsätze. Die damalige Zeitschrift ‘Speech’ ist als Mischform der heutigen ‘European Journal of Disorders of Communication’ und dem heutigen ‘Bulletin’ zu sehen.
Use of a deflectable tip catheter to facilitate complex interventions beyond insertion of coronary bypass grafts: Three case reports
Authors: Routledge Helen , Lefèvre Thierry , Ohanessian Alice , Louvard Yves , Dumas Pierre , Morice Marie‐Claude 
Published: November 2007

AbstractWe present three patients with angulated ostial lesions beyond the insertion point of coronary artery bypass grafts. Use of the Venture Catheter, a deflectable tip 3.5F wire control catheter, facilitated successful percutaneous coronary intervention after prolonged, unsuccessful attempts at conventional guidewire passage. © 2007 Wiley‐Liss, Inc.
Creation of a coronary sinus to atrial communication in coronary sinus ostial atresia improves cardiac function after Fontan
Authors: Petit Christopher J. , Webb Gary D. , Rome Jonathan J. 
Published: November 2007

AbstractCoronary sinus ostial atresia is a rare anatomic condition which is occasionally associated with drainage of coronary veins via a persistent left‐sided superior vena cava. This anatomic condition is normally clinically insignificant. However, when the systemic venous pressure is higher than that of the atrium, cardiac function can be impaired. We report our experience with a young adult who underwent a Fontan due to tricuspid atresia. The patient presented to our institution with poor systolic and diastolic ventricular function. A catheterization revealed an atretic coronary sinus ostium, and the coronary veins drained via a persistent left‐sided superior vena cava. Creation of a communication from coronary sinus to the common atrium resulted in a significant decrease in coronary venous pressures. The patient has experienced improvement following the interventiona catheterization. © 2007 Wiley‐Liss, Inc.
Multiplex assay for genetic testing of thrombophilia: a method for routine clinical care
Authors: López Mónica , Giraldo Pilar , Alvarez Patricia , Cornudella R. , Pocoví Miguel , Martínez Antonio , Fontcuberta Jordi , Soria José Manuel 
Published: November 2007

AbstractThere is an increasing demand for genetic testing of patients with hypercoagulability. We have developed a multiplex‐polymerase chain reaction (PCR) technique that incorporates the state‐of‐the art of genetic testing for thrombosis mutations (Factor V Leiden [FVL] and G20210A F2 and C46T F12). The sequences are detected by enzyme‐linked immunosorbent assay (ELISA)‐resolved colorimeter after hybridization with an amplification product labeled with digoxygenin. To evaluate the reliability of this method, we analyzed 122 deoxyribonucleic acid (DNA) samples of known genotypes for these three mutations. Six subjects initially assigned as heterozygous for FVL and two subjects assigned as normal for the G20210A F2 mutation showed discrepancies between the current techniques and our newly‐developed ELISA‐based technique. When these samples were sequenced the concordance using our method was 100%. Thus, initially they were assigned incorrectly based on the available methodologies. It is noteworthy that our method is adaptable to an Automated ELISA Analyzer that allows for routine processing of both small and large numbers of DNA samples. We present a robust, rapid, reproducible, cost‐effective, and simple multiplex PCR ELISA method to simultaneously detect carriers of thrombotic genetic risk factors. Testing for thrombophilia should contribute to better diagnosis, prevention, and treatment strategies, providing valuable information to assess the risk of recurrence in the proband, and in family members who are asymptomatic. J. Clin. Lab. Anal. 21:349–355, 2007. © 2007 Wiley‐Liss, Inc.
Determination of hydroxycamptothecinum by flow injection analysis with chemiluminescence detection
Authors: Liqing Li , Lin Guan , Ming Su , Hanwen Sun 
Published: November 2007

AbstractAn novel analytical method consisting of flow‐injection sampling and chemiluminescence (CL) detection for determination of anticancer drug hydroxycamptothecinum (HCPT) is described. It is based on the CL reaction of potassium permanganate–formaldehyde‐HCPT system. The formaldehyde‐sensitized CL emission mechanism was proposed for HCPT‐potassium permanganate (KMnO4)‐HCOH systems by comparing the fluorescence emission with CL spectra. Illuminant was the single‐state bimolecular oxygen, 1O21O2(1Δg1Δg), which was from 1O2(1Δg) produced in the reaction system, and emits CL spectra at 639 nm. The presence of formaldehyde can sensitized CL emission, because it may be to accelerate the generation of 1O2 (1Δg). The optimum conditions for CL emission were investigated and optimized. The CL intensity was correlated linearly with concentration of HCPT in the range of 0.010–60.0 mg L−1. The determination limit is 0.006 mg L−1. The relative standard deviation is 1.6% for 11 parallel measurements of 0.20 mg L−1 HCPT standard solution. The proposed method has been applied for the determination of HCPT in pharmaceutical preparations, serum, and urine. The results of the quantitative analysis for HCPT studied using the developed method showed a good agreement with provided by using an official method. J. Clin. Lab. Anal. 21:356–362, 2007. © 2007 Wiley‐Liss, Inc.
Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer
Authors: Bougatef Karim , Marrakchi Raja , Kourda Nadia , Lahely Yannick Blondeau , Jileni Sarra Baltagi Ben , El Khil Houssein K. , Soubrier Florent , Ammar Elgaaied Amel Ben 
Published: November 2007

AbstractThe MutYH gene is an adenine‐specific DNA glycosylase that prevents G/T transversions. Germline mutation in this gene causes MYH‐associated polyposis (MAP) that predispose to hereditary colorectal cancer (CRC). This study describes for the first time the association of the MutYH mutation with sporadic CRC. From the 48 Tunisian sporadic CRC cases analyzed, two patients showed somatic mutation of the MutYH gene. In addition, the two hotspot germline mutations MutYH Y165C and G382D seem to be infrequent in sporadic CRC. J. Clin. Lab. Anal. 21:372–374, 2007. © 2007 Wiley‐Liss, Inc.
Diagnostic value of Elecsys S100 as a marker of acute brain injury in the emergency department
Authors: Oh Eun‐Jee , Kim Young‐Min , Jegal Dong‐Wook , Kahng Jimin , Park Yeon‐Joon , Han Kyungja 
Published: November 2007

AbstractThe aim of this study was to evaluate the screening and diagnostic validity of the initial serum S100 levels by Elecsys S100 immunoassay in an emergency department. We measured serum S100 in 101 acute brain injury (ABI) patients, in 40 healthy subjects, and in 41 chronic brain injury (CBI) patients (the control group). The ABI patients were divided in several groups according to the Glasgow Coma Scale (GCS), injury type and findings of brain imaging. Of the 101 patients, the 66 cranial computed tomography (CCT) or brain magnetic resonance imaging (MRI)‐positive patients showed higher S100 levels than did the 35 CCT/MRI‐negative patients (P=0.028). At a cutoff of 0.105 µg/L, the sensitivity was 84.8% and the specificity 74.3% for all of the ABI patients, and the sensitivity was increased to 96.9% for the traumatic ABI patients for detecting image‐positive ABI. There was no significant difference of S100 levels among the groups on the CCT or MRI pathological findings (P=0.478). In conclusion, serum S100 levels can be used in the emergency department as an additional screening tool to identify CCT‐ or MRI‐positive ABI. J. Clin. Lab. Anal. 21:387–392, 2007. copy; 2007 Wiley‐Liss, Inc.
Genetic analysis of Indian subjects with clinical features of possible type IIa hypercholesterolemia
Authors: Kondkar Altaf A. , Nair Kappiareth G. , Ashavaid Tester F. 
Published: November 2007

AbstractWe performed genetic analysis in 55 patients with clinical features of possible type IIa hypercholesterolemia and 76 normolipemic healthy subjects for mutations and polymorphisms in the low‐density lipoprotein (LDL) receptor (LDLR), apolipoprotein B‐100 (APOB), apolipoprotein E (APOE), and hepatic lipase (LIPC) genes to elucidate the important genetic factors that can influence cholesterol levels in our population. None of the subjects showed mutations in part of exon 26 of the APOB gene, whereas two class 5 mutations were identified in exon 9 of the LDLR gene. First, an E387K mutation was observed in a Gujarati family in which both the parents were heterozygous for the mutation. Second, a L393R mutation was observed in a 38‐year‐old female. We found no correlation between LIPC −514C/T genotypes and cholesterol levels whereas the apoε4 allele frequency was significantly higher in cases and the apoE4 genotype was found to influence total cholesterol levels. J. Clin. Lab. Anal. 21:375–381, 2007. © 2007 Wiley‐Liss, Inc.
Diagnostic utility of pleural fluid carcinoembryonic antigen and CYFRA 21‐1 in patients with pleural effusion: a systematic review and meta‐analysis
Authors: Gu Ping , Huang Gang , Chen Yumei , Zhu Cuiying , Yuan Jimin , Sheng Shile 
Published: November 2007

AbstractPleural effusions (PE) are the most common complications that may be produced by a wide variety of diseases. A large number of studies exploring the role of carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21‐1) marker in differential diagnosis of PE have been published, employing differing methodologies with sometimes conflicting results. A comprehensive systematic review would be useful to synthesize the currently available bulk of information. The objective of this work was to assess and compare the overall value of pleural fluid CEA and CYFRA 21‐1 in differential diagnosis of PEs with a meta‐analysis. All the English and Chinese published studies for differential diagnosis of PEs by pleural fluid CEA and CYFRA 21‐1 were collected. Methodological quality of the included studies was evaluated. Pooled sensitivity and specificity were calculated, the threshold effect and the possible sources of heterogeneity were also analyzed. Summary receiver operating characteristic (SROC) curve analysis was used to compare the differential diagnostic ability of pleural fluid CEA and CYFRA 21‐1. A total of 19 studies were included in the meta‐analysis, with a total of 3,228 subjects. Pooled sensitivity and specificity of CEA and CYFRA 21‐1 were 45.9% (43.2–48.5%) and 97.0% (96.0–97.8%), and 47.3% (44.0–50.6%) and 91.8% (89.5–93.7%), respectively. Both CEA and CYFRA 21‐1 have a threshold effect, the main source of heterogeneity was from variable assay methods. The areas under the SROC curve (AUCs) of CEA and CYFRA 21‐1 were 0.7691 and 0.8213, respectively. There was no statistical significance between the AUC of CEA and CYFRA 21‐1 (P>0.05). Both CEA and CYFRA 21‐1 have good performance in the differential diagnosis of PE, when compared with CEA, CYFRA 21‐1 has no advantage. J. Clin. Lab. Anal. 21:398–405, 2007. © 2007 Wiley‐Liss, Inc.
Determination of urinary enzymes as a marker of early renal damage in diabetic patients
Authors: Mohammadi‐Karakani Ali , Asgharzadeh‐Haghighi Solmaz , Ghazi‐Khansari Mahmoud , Hosseini Rohollah 
Published: November 2007

AbstractDiagnosis of diabetic nephropathy in the early stages is very important since there are no clinical signs or symptoms. Urinary N‐acetyl‐β‐D‐glucosaminidase (NAG) excretion has been recommended as a tubular dysfunction marker that elevates before other markers, such as microalbuminuria and a decrease in creatinine clearance. In this study, we compared excretion of urinary enzymes with other markers that are used routinely in diabetic nephropathy assessment. Urinary NAG, lactate dehydrogenase (LDH), alkaline phosphatase (AP) activities, urea, creatinine, and albumin, with levels of serum glucose and creatinine and whole blood glycosylated hemoglobin (HbA1c) were measured in 32 diabetes mellitus patients and 25 healthy subjects (controls). Notably, urinary NAG, AP, LDH excretion, and microalbuminuria in the diabetic patients group were significantly increased compared to those in the control groups (P<0.001, P<0.05, P<0.01, and P<0.01, respectively). Meanwhile, our results showed that the urinary NAG excretion had the highest sensitivity and specificity (100% and 87.5%, respectively) compared to other markers. We showed that measuring urinary NAG excretion could be useful for the assessment of renal failure in diabetes mellitus patients and confirmed the use of NAG as a routine screening test. J. Clin. Lab. Anal. 21:413–417, 2007. © 2007 Wiley‐Liss, Inc.
Inhibition of HeLa Cell Apoptosis by Storage‐Protein 2
Authors: Rhee Won Jong , Lee Eun Hee , Park Ju Hyun , Lee Ji Eun , Park Tai Hyun 
Published: November 2007

AbstractApoptosis is a barrier to maintaining high viable cell densities in animal cell culture. Silkworm hemolymph and its 30K protein have been reported to exhibit anti‐apoptotic activity in various mammalian and insect cell systems. The 30K protein is thermally unstable at temperatures higher than 60 °C; however, the silkworm hemolymph heat‐treated at 70–80 °C still exhibited anti‐apoptotic activity. This indicates that silkworm hemolymph contains another anti‐apoptotic compound other than 30K protein. In this article, the anti‐apoptotic molecule other than 30K protein was found from the silkworm hemolymph and identified. This molecule was storage‐protein 2 (SP2), which has no homology with any known anti‐apoptotic protein. This molecule was heat‐stable up to 80 °C, while 30K protein lost its activity at temperatures higher than 60 °C. When apoptosis was induced by staurosporine in HeLa cells, SP2 protein suppressed nuclear fragmentation and apoptotic body formation. Moreover, the generation of reactive oxygen species after apoptosis induction was inhibited, which means the inhibition occurred in an early step of the apoptotic process. Inhibition of apoptosis by the SP2 protein would lead to the minimization of cell death during commercial mammalian cell culture.
A simplified oral glucose tolerance test in pregnancy: compliance and results
Authors: ANDERBERG EVA , Källén Karin , BERNTORP KERSTIN , FRID ANDERS , ÅBERG ANDERS 
Published: November 2007

AbstractBackground. To describe a reliable method for a general oral glucose tolerance test (OGTT) during pregnancy, to evaluate adherence to the method, and to compare the frequency of reported gestational diabetes mellitus (GDM) and perinatal outcome in affected pregnancies in Skåne, using direct diagnostic OGTT, with those from a comparable area, Halmstad‐Ljungby‐Växjö (HLV), using random glucose measurements (RGM) to identify women for the OGTT. Methods. The OGTT program and quality assurance in Skåne is described. Antenatal records on deliveries in May 2003 were scrutinised to ascertain if OGTT had been performed. Frequencies of GDM, prematurity and large for gestational age (LGA) infants were estimated using a population‐based perinatal database (PRS). Results. OGTT was performed in 93% of pregnant women in Skåne. In 2000–2003 GDM frequency in Skåne was twice as high as in HLV (1.9 versus 1%), while the frequency of LGA and prematurity among infants of mothers who were diagnosed with GDM were similar. Conclusions. Decentralised general OGTT is a reliable and effective method to diagnose GDM. OGTT is twice as sensitive as RGM, and the severity of GDM in the cases identified with OGTT did not differ from the severity of those identified with RGM.
Laparoscopic laser resection of rectovaginal pouch and rectovaginal septum endometriosis: the impact on pelvic pain and quality of life
Authors: KRISTENSEN JENS , Jørgen Kjer Jens 
Published: November 2007

AbstractBackground. The aim of this study was to assess the impact on pelvic pain and quality of life of laparoscopic resection of the rectovaginal pouch (RV) and RV septum in patients with endometriosis. Methods. The design was a descriptive retrospective study. The study included 48 women presenting to the Department of Obstetrics and Gynaecology with RV pouch and RV septum endometriosis, between 1 January 2003 and 1 January 2006. The setting was a university teaching hospital, one of two referral centres in Denmark for the surgical treatment of stage III and IV endometriosis. Questionnaires and Visual Analogue Scale (VAS) scores for a number of different symptoms associated with endometriosis were used. The main outcome measures were: effect of laparoscopic excision on pain scores and quality of life, operative findings, type of surgery, duration of surgery, and incidence of intra‐ and postoperative complications. Results. Significant statistical differences were found between preoperative and postoperative pain scores, quality of life, frequency of sexual activity, percentage taking analgesics or non‐steroidal anti‐inflammatory drugs, percentage having work difficulties due to pain, and percentage of women having sick‐leave. Conclusion. Endometriosis in the RV pouch and RV septum can be effectively treated with laser laparoscopy performed by experienced endoscopic gynaecologists.
Does acupuncture used in nulliparous women reduce time from prelabour rupture of membranes at term to active phase of labour? A randomised controlled trial
Authors: SELMER‐OLSEN TONE , LYDERSEN STIAN , MØRKVED SIV 
Published: November 2007

AbstractBackground. To assess if acupuncture influences the onset of labour and the need for induction after prelabour rupture of membranes (PROM) in nulliparous women. Further, to investigate a possible effect of acupuncture on the woman's wellbeing. Methods. In a randomised controlled trial (RCT), 106 nulliparous women with PROM were allocated to an acupuncture group (AG) or a control group (CG). The outcome measures were time from PROM to onset of active phase of labour, and rate of inductions if labour was absent after 2 days. The women's self‐reported wellbeing was registered on a Visual Analogue Scale (VAS). Results. There was no statistically significant difference between the 2 groups regarding time from PROM to active phase (median times in AG versus CG: 15 versus 20.5 h, p = 0.34). Additionally, there was no difference between the 2 groups in the need for induction. We found no significant differences in self‐reported wellbeing, but the women receiving acupuncture considered their treatment to be more positive than the controls (p = 0.003). No adverse effects were reported. Conclusions. Acupuncture treatment used in nulliparas after PROM showed no significant effect in reducing time to active labour or in reducing rate of inductions. There was no change in wellbeing as a result of acupuncture, but it was considered positive to receive this kind of treatment while waiting for labour to begin.
Utero‐vaginal anastomosis in the treatment of cervical atresia
Authors: JASONNI VALERIO M. , LA MARCA ANTONIO , MATONTI GIUSEPPE 
Published: November 2007

AbstractCervical atresia is an extremely rare malformation. Its incidence is not well known and management is controversial. The surgical technique and results of utero‐vaginal anastomosis in 3 women affected by cervical atresia are described.