bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis
Authors: Ai Daosheng , Ming Tianyue , Li Xiaoli , Wang Shu , Bi Zhanying , Zuo Jinyi , Cheng Zizhang , Sun Weijin , Xie Mingguo , Li Fengzhi , Wang Xiongfei , Qi Xueling , Luan Guoming , Ge Woo‐ping , Guan Yuguang 
Published: February 2025

AbstractSturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformation, resulting in significant risks of life‐threatening seizures and strokes. The current absence of specific treatments underscores the need to define the molecular and cellular mechanisms that drive the progression of SWS. Here, the transcriptome of 119 446 cells isolated from both malformed tissues and peri‐lesion tissues from the brains of patients with SWS is examined. This comprehensive analysis finds a complex landscape of cell heterogeneity and distinct cell substate associated with the evolution of this disease are revealed. Notably, a unique fibroblast cluster and molecular mechanism are identified that contribute to the development of SWS. These findings not only expand the understanding of SWS but also open up promising avenues for therapeutic interventions.
Cultivation of filamentous fungi in airlift bioreactors: advantages and disadvantages
Authors: Cerrone Federico , O’Connor Kevin E. 
Published: February 2025

Abstract
Filamentous fungi or mycelia are a valuable bioresource to produce several biomolecules and enzymes, especially because of their biodegradation potential and for their key role of enablers of a circular bioeconomy. Filamentous fungi can be grown in submerged cultivation to maximise the volumetric productivity of the bioprocess, instead of using the more established and time-consuming solid-state cultivation. Multicellular mycelia are sensitive to shear stresses induced by mechanical agitation, and this aspect greatly affects their morphology in submerged cultivation (pelletisation) and the connected volumetric productivity. An efficient compromise is the growth of filamentous fungi in airlift bioreactors (ALR) where the volumetric oxygen transfer (KLa) is optimal, but the shear stress is reduced. In this review, we critically analysed the advantages and disadvantages of ALR-based cultivation of filamentous fungi, comparing these bioreactors also with stirred tank reactors and bubble column reactors; we focused on scientific literature that highlights findings for the cultivation of filamentous fungi for both the production of enzymes and the production of myco-biomass in ALR; we included studies for the control of the pelletisation of the fungal biomass in batch and semi-continuous cultivation, highlighting the interlinked hydrodynamics; finally, we included studies regarding the modifications of ALR in order to enhance filamentous fungi production.

Key points

• ALR are efficient for batch and prolonged continuous cultivation of filamentous fungi.

• ALR show both optimal gas hold-up and K

L

a with an airflow that has high superficial velocity and critical bubble diameter (1–6 mm).

• Suspended mycelia aggregates (pellet) maintain a fluidised motion in ALR if their size/density can be controlled.
Trends in chronic neck and low back pain prevalence in Spain (2006–2020): differences by sex, age, and social class
Authors: Huerta Miguel Á. , Salazar Alejandro , Moral-Munoz Jose A. 
Published: February 2025

Abstract

Purpose
To analyze the evolution of chronic neck and low back pain prevalence in the general Spanish population (≥ 15 years) from 2006 to 2020, examining differences by sex, age, social class, and the potential influence of the COVID-19 pandemic.

Methods
A repeated cross-sectional observational study was conducted based on data from six health surveys conducted in Spain between 2006 and 2020, with samples ranging from 21,007 to 29,478 subjects per survey, reported by the European Statistical System and the National Statistical Institute. Overall and specific prevalence rates were calculated, and linear trends were assessed over time. The potential influence of the COVID-19 pandemic was evaluated using the Mann-Kendall test, along with prevalence forecasts up to 2020, derived from S-curve models.

Results
Between 2006 and 2020, the prevalence of chronic neck pain ranged from 23.64 to 12.3%, while chronic low back pain ranged from 24.01 to 14.73%. A decreasing trend was observed in both conditions, slightly more pronounced for neck pain. This trend persisted even when excluding 2020 data, which was potentially influenced by the COVID-19 pandemic, and was independent of health surveys. Forecasts indicated that the actual 2020 prevalence rates were lower (by 3.1–4.4%) than predicted. The prevalence was consistently higher among women, older individuals, and lower social classes, though all subgroups showed similar decreasing trends.

Conclusion
The prevalence of chronic neck and low back pain in the Spanish population declined between 2006 and 2020. Subgroup analyses revealed consistent decreases across sex, age, and social class. The COVID-19 pandemic may have impacted the 2020 prevalence rates.
An exploratory kinetic analysis of photoelectrochemical oxygen evolution on hematite
Authors: Peter Laurence M. 
Published: February 2025

Abstract
The kinetics of the photoelectrochemical oxygen evolution reaction (POER) on hematite photoanodes are explored using a simple reaction scheme involving an initial pre-equilibrium hole/proton transfer step to form an Fe(IV) surface species, Fe = O, followed by a rate-determining hole/proton transfer step to form the Fe(II) peroxo species, FeOOH, which then reacts rapidly with two more holes to form oxygen. The modelling considers how the kinetics of these two reaction steps are affected by changes in

$${V}_{\text{H}}$$

V
H

, the potential drop across the Helmholtz layer that arises from the build-up of positive charge at the interface under illumination. The model, which also considers electron–hole recombination and back reaction of Fe = O with conduction band electrons, is used to calculate steady-state photocurrent/voltage characteristics, pseudocapacitance-voltage plots, and transient absorbance (TAS) responses that can be compared with published results. The model is also used to show that the slopes of double logarithmic reaction order plots of photocurrent vs. hole or reaction intermediate concentrations are influenced by light-induced changes in

$${V}_{\text{H}}$$

V
H

. The insights from this analysis should be relevant to the ongoing discussion of multi-hole mechanisms for the POER on hematite photoanodes.
Nonlinear Relations of Viscous Stress and Strain Rate in Nonlinear Viscoelasticity
Authors: Machill Lennart 
Published: February 2025

Abstract
We consider a Kelvin–Voigt model for viscoelastic second-grade materials, where the elastic and the viscous stress tensor both satisfy frame-indifference. Using a rigidity estimate by Ciarlet and Mardare (J. Math. Pures Appl. 104:1119–1134, 2015), existence of weak solutions is shown by means of a frame-indifferent time-discretization scheme. Further, the result includes viscous stress tensors which can be calculated by nonquadratic polynomial densities. Afterwards, we investigate the long-time behavior of solutions in the case of small external loading and initial data. Our main tool is the abstract theory of metric gradient flows (Ambrosio et al. in Gradient Flows in Metric Spaces and in the Space of Probability Measures, Birkhäuser, Basel, 2005).
Physical properties of zinc, silver, or cerium ion doped borate glass incorporated PCL/gelatin electrospun fibers and their interaction with NG108-15 neural cells
Authors: Ege Duygu , Khalili Vida , Lu Hsuan-Heng , Reinfelder Heike , de Ligny Dominique , Boccaccini Aldo R. 
Published: February 2025

Abstract
In this study, 1393-B3 based borate bioactive glasses (BGs) undoped and doped with 1 wt% zinc (ZnBG), cerium (CeBG), or silver (AgBG) were prepared and were incorporated into gelatin/PCL (GEL/PCL) electrospun fibers for neural tissue engineering applications. Particle sizes of the prepared BGs were 3.1, 10.6, 14.6, and 3.7 µm for undoped BG, ZnBG, AgBG, and CeBG, respectively. Aligned electrospun fibers were prepared with 5 wt% of BG particles to produce 5BG/PCL/GEL, 5ZnBG/PCL/GEL, 5AgBG/PCL/GEL and 5CeBG/PCL/GEL fibers. Random 5CeBG/PCL/GEL fibers were also prepared for comparison. A rise in fiber diameter was measured for BG-incorporated fibers compared to PCL/GEL fibers. Mechanical tests on the fibers indicated ultimate tensile strength values of 1–3.5 MPa, the range of mechanical properties of neural tissue. Cell culture studies were carried out with the NG108-15 cell line. Cell alignment was observed on the electrospun fibers on day 2. On days 1 and 2, the optical density was higher for ZnBG/PCL/GEL, CeBG/PCL/GEL, and AgBG/PCL/GEL than for BG/PCL/GEL fibers. On day 4, undoped BG-containing nanofibers had higher optical density compared to those containing doped BGs. This result could be due to a slower release rate of boron from the pure BG/PCL/GEL fiber mat. Overall, within the studied range, all fiber mats were found to be suitable for neural tissue engineering in terms of neural cell compatibility and mechanical properties. In the future, a wider range of ion doping must be considered to fully comprehend the potential of such ion-releasing fibers for neural regeneration.

Graphical Abstract
Facile Synthesis of Co-MOF Nanoflakes as an Efficient and Durable Electrocatalyst for HER and OER Applications in Alkaline Medium
Authors: Abdelwahab Mohamed A. , Mohamed Gehad G. , Eliwa Ayman S. 
Published: February 2025

Abstract
Water splitting is essential for storing sustainable energy and producing hydrogen in an environmentally friendly manner. In recent years, metal–organic frameworks (MOFs) have gained recognition for their versatility, characterized by their large surface areas, adjustable porosity, and ability to undergo easy composition modification. These properties make MOFs and their derivatives promising candidates for catalyzing water electrolysis. The MOF studied here contains cobalt as its metal center and a Schiff base linker derived from 2-aminobenzoic acid and terephthalaldehyde. The synthesized powder underwent thorough analysis using techniques such as Fourier-transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) surface area measurement, and thermal analysis. The efficiency of the Co-MOF in water splitting was assessed, demonstrating significant catalytic performance comparable to other modified MOF catalysts reported in literature. Specifically, the hydrogen evolution electrode achieved a current density of 10 mA/cm² with an overpotential of 37 mV (vs. Ag/AgCl) and a Tafel slope of approximately 100 mV dec⁻¹. For oxygen evolution at 100 mA/cm², an overpotential of 803 mV (vs. Ag/AgCl) and a Tafel slope of 226.6 mV dec⁻¹ were observed.
The urgency-necessity earthquake alert trade-off: considering the public response factor
Authors: Nof Ran Novitsky , Yagoda-Biran Gony , Zwebner Yonat 
Published: February 2025

Abstract
Implementing Earthquake Early Warning Systems’ (EEWS) alerting strategy entails a trade-off between urgency and necessity. Large uncertainties at initial stages might lead to issuing urgent alerts for non-damaging earthquakes. This, in turn, can lead to unnecessary indirect injuries caused by peoples’ responses to alerts. Conversely, necessary yet delayed alerts with higher certainties can lead to preventable harm. In this work, we aim to balance these approaches and optimize alerting strategies by integrating multidisciplinary datasets. First, we estimate potential costs associated with non-damaging earthquake alerts by integrating a unique dataset of indirect injuries caused by missile attacks in Israel with the uncertainties of Truaa, the operational Israeli EEWS. The findings reveal that injury costs from urgent alerts are much lower than those from delayed alerts. Additionally, we distributed a questionnaire in Israel following the February-2023 Kahramanmaraş, Türkiye earthquakes revealing the public’s preference for urgent alerts, despite alert uncertainties. By considering injury costs and social perspectives, we highlight the need to optimize alerting strategies and to consider reducing the alert magnitude threshold by incorporating social factors. This approach offers insights for making well-informed decisions to enhance the effectiveness of the Israeli EEWS.
An Integrated In Vitro and In Silico Investigation of the Bioactive Properties of Wild Glycyrrhiza glabra var. glandulifera
Authors: Kızıl Hamit Emre , Ulcay Sibel , Ekincioğlu Yavuz , Öğütçü Hatice , Ağar Güleray 
Published: February 2025

Abstract
This investigation examined methanol extracts obtained from the whole plant (encompassing all organs except roots), flowers, and fruits of wild Glycyrrhiza glabra var. glandulifera, a liquorice cultivar indigenous to the Cappadocia region of Türkiye, constituting the first comprehensive in vitro and in silico analysis of this species within the region. Anatomical identification revealed distinctive structural characteristics, including thick-walled epidermal cells in the stem, organized clusters of collenchyma cells, and well-defined sclerenchyma layers encompassing the vascular bundles. The petiole exhibited a characteristic heart-shaped morphology containing three vascular bundles, while foliar analysis demonstrated the presence of stomata on both adaxial and abaxial surfaces, accompanied by a bifacial mesophyll arrangement. The extracts demonstrated remarkable antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, as well as various fungal species. Furthermore, significant cytotoxic activity was observed against non-small cell lung cancer (H460), with the whole plant extract exhibiting IC50 values of 117.8 µg/mL (24 h) and 105.6 µg/mL (48 h). Flower extracts demonstrated IC50 values of 116.8 µg/mL (24 h) and 112.7 µg/mL (48 h), while fruit extracts displayed superior potency with IC50 values of 104.4 µg/mL (24 h) and 63.09 µg/mL (48 h). Molecular docking analyses, conducted utilizing AutoDock Tools 1.5.6 and BIOVIA Discovery Studio Visualizer 4.5, revealed significant protein-ligand interactions, yielding optimal binding energy and inhibition constant values of -9.57 kcal/mol and 96.92 nM, respectively. The RMSD values were calculated based on structural variations between ligand-protein complexes during re-docking procedures. These findings underscore the substantial biological potential of Glycyrrhiza glabra var. glandulifera from Cappadocia, necessitating further comprehensive investigation.
PROM („patient-reported outcome measures“) in der onkologischen Nachsorge der Schweiz: Eine SWOT-Analyse aus der Perspektive der Gesundheitsförderung und Prävention
Authors: Bossart Eveline , Glässel Andrea 
Published: February 2025

Zusammenfassung

Hintergrund und Ziel
In der Schweiz leben rund 400.000 Cancer Survivors, wovon viele eine geringere Lebensqualität aufweisen als vor der Erkrankung. PROM („patient-reported outcome measures“) ermöglichen, die Patient:innenperspektive bezüglich Lebensqualität und Symptomstatus systematisch zu erheben und diese Daten für die weitere Behandlung in der onkologischen Nachsorge zu nutzen. Ziel dieser Arbeit ist es, Stärken, Schwächen, Chancen und Risiken (SWOT) des Einsatzes von PROM in der onkologischen Nachsorge zu explorieren, um daraus Handlungsempfehlungen für die Krebsliga Schweiz abzuleiten.

Methoden und Studiendesign
Ein dreistufiges Verfahren kam zu Anwendung: a) selektive Literaturübersicht zum Stand der PROM in der Schweiz; b) Erhebung und thematische Auswertung von fünf leitfadengestützten, qualitativen Expert:innen Interviews; c) Ergebnissynthese anhand einer SWOT-Analyse zur Ableitung von Handlungsempfehlungen für die Krebsnachsorge in der Schweiz.

Ergebnisse
Fünf Hauptkategorien bilden die Grundlage für die Einordnung in die SWOT-Analyse. Die Förderung von Patient:innenorientierung und Interprofessionalität stehen als Stärken der PROM im Vordergrund. Komplexe Anforderungen an bestehende digitale Infrastruktur bilden eine Schwäche. Chancen werden in einer geschlossenen Versorgungskette und der Verringerung von Gesundheitskosten gesehen, während unklare Zuständigkeiten und das föderalistische Gesundheitssystem zu den Risiken zählen. Im Sinne der Ottawa-Charta der Gesundheitsförderung werden der Krebsliga Schweiz Aktivitäten vorgeschlagen.

Schlussfolgerung
Unter dem Anspruch der Chancengerechtigkeit sind PROM allen Betroffenen in der Schweiz zugänglich zu machen. Akteure und Organisationen sollen sich für eine flächendeckende Einführung von PROM in der onkologischen Nachsorge einsetzen.
Language Concordance and Interpreter Use for Spanish-Preferring Patients: Qualitative Study of Perspectives from Primary Care Providers
Authors: Quigley Denise D. , Qureshi Nabeel , Talamantes Efrain , Predmore Zachary 
Published: February 2025

Abstract

Background
Poor quality communication and language barriers lead to worse care experiences and inferior health care outcomes for those with limited English proficiency. Fewer than one-third of outpatient providers regularly use professional interpreters when communicating with non-English preferring patients. Effective strategies to address language barriers in primary care are lacking and in demand.

Objective
Examine provider perspectives on providing in-person care to Spanish-preferring patients.

Design
Partnered with a large, urban Federally Qualified Health Center predominantly caring for Spanish-preferring Hispanic patients, we identified primary care providers who (1) were language-concordant (provider and patient speak same language); (2) used qualified interpreters; and (3) used informal strategies for interpretation/communication.

Participants
We interviewed 24 providers (10 language-concordant, 9 who used qualified interpreters, 5 who used informal interpreters and other strategies; response-rate 23%).

Approach
We established codes using systematic, inductive procedures to generate insights from responses and identified themes using content analysis.

Results
Providers—both language-concordant and those using interpreters—preferred to speak the same language as the patient, employed varying communication strategies, and required more time to care for Spanish-preferring patients for differing reasons. Using interpreters did not always improve communication because using qualified interpreters requires more time for initiating interpretation, connectivity issues, and conducting consecutive interpretation; using any interpreter requires provider-interpreter clarification or staff to translate, and sometimes interpreters had difficulty with medical content/terminology. Provider-patient visits also qualitatively differed based on language spoken and interpreter use in eliciting concerns, topics covered, patient comprehension, and time spent on rapport-building and patient education.

Conclusions
Providers described barriers that organizations need to address to facilitate effective communication and language interpretation when caring for Spanish-preferring patients. Research is needed that identifies and tests language support strategies for providers and clinics and structural changes that preserve time during patient visits for providers and patients to spend on health care needs.
Neuromorphic Hardware for Artificial Sensory Systems: A Review
Authors: Kim Youngmin , Lee Chung Won , Jang Ho Won 
Published: February 2025

Abstract
Senses are crucial for an organism’s survival, and there have been numerous efforts to artificially replicate sensory perception to elicit desired responses to specific stimuli. Recent research is increasingly focused on developing artificial sensory nervous systems based on the unsupervised learning capabilities of artificial neural networks (ANNs) using unstructured data. However, future ANNs, which require precise sensing capabilities in increasingly complex environments, must be capable of processing a large number of signals in real time, ideally from continuous domains. This need for massive data processing is driving the evolution of hardware systems, leading to the development of devices specifically designed for artificial sensory systems (ASSs) at the hardware level. To address this challenge, sensor devices need to not only detect target substances but also enable computational functions by utilizing their inherent material properties. Research in neuromorphic sensors is advancing towards integration with next-generation processing systems based on ANNs, effectively addressing the complex scenarios we aim to identify. This review offers perspectives on human-like sensor computing to address these challenges. It examines the progress in implementing five representative senses at the device level, explores methods for integrating them into systems for ASS, and provides a comprehensive overview of potential applications. In particular, we emphasize approaches to cognitively utilize the discussed devices as artificial sensory neurons and synapses, enabling responses to specific inputs. We aim to offer perspectives for the development of artificial sensory nerve systems in the future.
Red Meat Consumption and Hypertension: An Updated Review
Authors: Allen Tara S. , Najem Michael , Wood Alexis C. , Lee Danielle J. , Pacheco Lorena S. , Daniels Lori B. , Allison Matthew A. 
Published: February 2025

Abstract

Purpose of Review
Hypertension (HTN) is a major risk factor for cardiovascular diseases (CVD). The global prevalence of HTN and related CVD mortality continues to rise. The development of HTN is influenced by genetic predisposition and modifiable risk factors, including diet. One area of ongoing debate is the relationship between red meat consumption and risk of HTN.

Recent Findings
Processed red meat has become increasingly implicated in the pathogenesis and morbidity of HTN, though randomized control trials comparing HTN-related outcomes associated with red meat subtypes have yielded heterogenous results.

Summary
This review summarizes the existing relevant literature and highlights the methodological challenges that complicate definitive conclusions, with a focus on processed versus unprocessed red meat consumption and HTN. It explores pathophysiologic mechanisms contributing to this relationship and reviews practical, evidence-based dietary guidelines that address red meat consumption to mitigate the risk of adverse HTN-related CVD outcomes.