bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Epidermal Growth Factor Receptor or ErbB3 Facilitates Geldanamycin-Induced Down-Regulation of ErbB2
Authors: Pedersen Nina Marie , Breen Kamilla , Rødland Marianne Skeie , Haslekås Camilla , Stang Espen , Madshus Inger Helene 
Published: February 2009

Abstract
Overexpression of the epidermal growth factor receptor (EGFR), ErbB2, and ErbB3 promotes growth and antiapoptotic signaling. Overexpression of ErbB2 in breast cancer is associated with poor clinical outcome, and ways of down-regulating ErbB2 are important as therapeutic approaches. In contrast to EGFR, ErbB2 has been shown to be endocytosis deficient. However, down-regulation of ErbB2 can be induced by incubation of cells with geldanamycin and geldanamycin derivatives, counteracting the stabilizing function of heat shock protein 90 on ErbB2. In the present study, we have made use of stably transfected isogenic cell lines expressing ErbB2 only or ErbB2 together with EGFR and/or ErbB3. We now show that whereas ErbB2 can be down-regulated by incubation with geldanamycin in cells expressing ErbB2 only, the rate of geldanamycin-induced down-regulation increases significantly when the cells additionally express EGFR and/or ErbB3. This increase does, however, not correlate with activation/phosphorylation of ErbB2. The potential of heterodimer formation in ErbB2-positive breast cancer cells could thus turn out to be prognostically predictive with respect to outcome of treatment with geldanamycin derivatives. (Mol Cancer Res 2009;7(2):275–84)
A Printed Muslim “Lighthouse” in Cairo al-Manār's Early Years, Religious Aspiration and Reception (1898-1903)
Authors: Ryad Umar 
Published: February 2009

AbstractOn the basis of fresh documents the article tried to reconstruct a historical description of the establishment of the most well-known reformist magazine al-Manār. The personal papers of its founder Muhammad Rašīd Ridā uncover new information about the background of his journalistic plans and religious aspirations after his arrival in Egypt in 1897. The paper reconsiders Ridā's early religious formation and apprenticeship in his homeland Syria; his position in the printing press in Egypt; the early funding of his magazine; his early integration in the Egyptian life; the early circulation of al-Manār; and his perspectives on the craft of printing in serving religious sciences.
Scanning electron microscope study on the egg chorion of silkmoth, Antheraea assamensis Helf. (Lepidoptera : Saturniidae)
Authors: Kumar Vineet , Kamble Chandrakant 
Published: February 2009

AbstractThe eggshell of Antheraea assamensis Helf. has a highly decorated chorion and its micropylar apparatus is situated at the cephalic end. Scanning electron microscopic investigation on the eggshells of A. assamensis reveals distinct patterns of structural elements viz., central cavity, micropylar rosette encircled the central cavity, and the aeropyles. The micropylar structures are at the anterior pole of the oval shaped eggs opposite to its side of distal pole. Centrally located central cavity leads into eight micropylar openings which further radiate down to the eight micropylar canals. The central cavity (5.28±0.21 μm in diameter) is encircled by a primary rosette of 16-18 cell imprints and each primary cell imprint measured 21.08±3.13 μm in length. The primary petal shaped cell imprints are followed by secondary and tertiary rows of cell imprints. Except the central cavity and micropylar rosette, the entire surface of the chorion is marked by a circular shell imprints which are boarded by aeropyles. Each cell imprint has 4-6 aeropyles and each aeropyle measured 1.06±0.01 μm in diameter. The aeropyles of A. assamensis are covered with a cup shaped like structures and the terminals of these structure has many finger like projections which may help to check the entry of pathogens or dust particles while taking the oxygen from the outside environment to the oocyte.
Features predicting the success of computerized decision support for prescribing: a systematic review of randomized controlled trials
Authors: Mollon Brent , Chong Jaron JR , Holbrook Anne M , Sung Melani , Thabane Lehana , Foster Gary 
Published: February 2009

Abstract

Background
Computerized decision support systems (CDSS) are believed to have the potential to improve the quality of health care delivery, although results from high quality studies have been mixed. We conducted a systematic review to evaluate whether certain features of prescribing decision support systems (RxCDSS) predict successful implementation, change in provider behaviour, and change in patient outcomes.

Methods
A literature search of Medline, EMBASE, CINAHL and INSPEC databases (earliest entry to June 2008) was conducted to identify randomized controlled trials involving RxCDSS. Each citation was independently assessed by two reviewers for outcomes and 28 predefined system features. Statistical analysis of associations between system features and success of outcomes was planned.

Results
Of 4534 citations returned by the search, 41 met the inclusion criteria. Of these, 37 reported successful system implementations, 25 reported success at changing health care provider behaviour, and 5 noted improvements in patient outcomes. A mean of 17 features per study were mentioned. The statistical analysis could not be completed due primarily to the small number of studies and lack of diversity of outcomes. Descriptive analysis did not confirm any feature to be more prevalent in successful trials relative to unsuccessful ones for implementation, provider behaviour or patient outcomes.

Conclusion
While RxCDSSs have the potential to change health care provider behaviour, very few high quality studies show improvement in patient outcomes. Furthermore, the features of the RxCDSS associated with success (or failure) are poorly described, thus making it difficult for system design and implementation to improve.
Intradural squamous cell carcinoma in the sacrum
Authors: Fukushima Tatsuki , Kasai Yuichi , Kato Ko , Fujisawa Kozo , Uchida Atsumasa 
Published: February 2009

Abstract

Background
Leptomeningeal carcinomatosis occurs in patients with cancer at the rate of approximately 5%; it develops particularly in patients with breast cancer, lung cancer, melanoma, leukemia, or malignant lymphoma. We describe a rare case of leptomeningeal carcinomatosis in which spinal intradural squamous cell carcinoma with no lesions in the cerebral meninges and leptomeninx, was the primary lesion.

Methods
A 64-year-old man complained of sacral pain. Although the patient was treated with analgesics, epidural block and nerve root block, sacral pain persisted. Since acute urinary retention occurred, he was operated on. The patient was diagnosed as having an intradural squamous cell carcinoma of unknown origin.

Results
Since the patient presented with a slightly decreased level of consciousness 2 months after surgery, he was subjected to MRI scanning of the brain and spinal cord, which revealed disseminated lesions in the medulla oblongata. The patient died of pneumonia and sepsis caused by methicillin-resistant Staphylococcus aureus 5 months after surgery.

Conclusion
We report the first case of a patient with intradural squamous cell carcinoma with unknown origin that developed independently in the sacrum.
Binding of long-chain α-neurotoxin would stabilize the resting state of nAChR: A comparative study with α-conotoxin
Authors: Nasiripourdori Adak , Ranjbar Bijan , Naderi-Manesh Hossein 
Published: February 2009

AbstractBackgroundThe details of interaction in a complex between potent antagonists such as long chain α-neurotoxins and α-conotoxins with nicotinic acetylcholine receptor (nAChR), and conformational changes induced by these antagonists, are not yet clear.ModelingIn order to uncover some of these critical structural features, we conducted a docking simulation and a molecular dynamics simulation (MD) of a model of the ligand binding domain of nAChR in complex with a long-chain α-neurotoxin and an α-conotoxin.ResultsOur docking results confirm the claim thatT.nAChR is in the basal or resting state, which favors binding to the alpha-neurotoxins. Moreover, more correct "hits" for the α/γ interface upon docking for conotoxin-nAChR confirm the preference of conotoxin GI for the α/γ interface. More importantly, upon binding of α-neurotoxin, ligand-bonded nAChR is less dynamic in certain domains than the apo form of the conotoxin-AChR complex. Some critical interactions in the binding site such as the salt bridge formed between K145/D200 in the neurotoxin-nAChR complex is further stabilized during the MD simulation, while it is obviously more labile in the apo form.ConclusionThese observations could support the claim that alpha neurotoxins stabilize the nAChR resting state.
Identification of the occurrence and pattern of masseter muscle activities during sleep using EMG and accelerometer systems
Authors: Yoshimi Hidehiro , Sasaguri Kenichi , Tamaki Katsushi , Sato Sadao 
Published: February 2009

AbstractBackgroundSleep bruxism has been described as a combination of different orofacial motor activities that include grinding, clenching and tapping, although accurate distribution of the activities still remains to be clarified.MethodsWe developed a new system for analyzing sleep bruxism to examine the muscle activities and mandibular movement patterns during sleep bruxism. The system consisted of a 2-axis accelerometer, electroencephalography and electromyography. Nineteen healthy volunteers were recruited and screened to evaluate sleep bruxism in the sleep laboratory.ResultsThe new system could easily distinguish the different patterns of bruxism movement of the mandible and the body movement. Results showed that grinding (59.5%) was most common, followed by clenching (35.6%) based on relative activity to maximum voluntary contraction (%MVC), whereas tapping was only (4.9%).ConclusionIt was concluded that the tapping, clenching, and grinding movement of the mandible could be effectively differentiated by the new system and sleep bruxism was predominantly perceived as clenching and grinding, which varied between individuals.
Lost in translation: An interpretative phenomenological analysis of mental health professionals' experiences of empathy in clinical work with an interpreter
Authors: Pugh Matthew A. , Vetere Arlene 
Published: February 2009

Objectives. Although empathy is considered by many to be fundamental to psychotherapeutic practice, little is known about how working with an interpreter may affect empathy in clinical work. Accordingly, the present study aims to provide an exploration of mental health professionals' experiences of empathy in clinical work with an interpreter.Design. A qualitative methodology was utilized in order to provide a rich understanding of participants' shared experiences of empathy in work with an interpreter. Data were gathered using a semi‐structured interviewing approach. Interpretative phenomenological analysis (IPA) was chosen as the method of analysis as this would provide a highly descriptive and in‐depth account of participants' experiences.Method. Interviews were conducted with 10 mental health professionals regularly working with linguistic interpreters. Interviews were transcribed and analysed using IPA.Results. The analysis yielded four major themes which described the effects of translation upon empathic dialogues with service‐users; changes in the quality of empathic communication with service‐users; the effects of cultural similarities and dissimilarities upon empathy within client–interpreter and client–professional dyads; and opportunities for the interpreter to enrich participants' understanding of service‐users' perspectives.Conclusions. The difficulties participants encountered in work with an interpreter highlight a need for training in cross‐language empathy for interpreters and mental health professionals, and encourage the use of transcultural models of psychotherapy in work with non‐English speaking service‐users. Some of the difficulties associated with adopting traditional humanistic models of empathy, which tend to centralize the therapist within empathic processes, when working with interpreters are also discussed.
Die Schwa-Erweiterung in der deutschen Konjugation, natürliche Klassen und die Notwendigkeit des Merkmals „approximant“
Authors: Kefer Michel 
Published: February 2009

Abstract
In this paper dealing with schwa insertion in German conjugation, two rules are worked out and shown to be each necessary. They are compared with other formulations found in the literature. Some general problems related to the two rules are discussed, especially natural classes and the Naturalness Condition in phonology. One of the rules and the Naturalness Condition are used to show the necessity of the phonetic feature “approximant”.
Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome
Authors: Diamanti-Kandarakis Evanthia , Piouka Athanasia , Livadas Sarantis , Piperi Christine , Katsikis Ilias , Papavassiliou Athanasios G , Panidis Demetrios 
Published: February 2009

ObjectiveOocyte maturation process characterizes polycystic ovary syndrome (PCOS). The mechanisms of this abnormality leading to chronic anovulation are under investigation. Advanced glycosylated end products (AGEs), a marker of oxidative stress linked with oocyte maturation are localized in granulosa cells and are increased in sera, in women with PCOS. The aim of this study was to investigate the relationship, whether there is an association between the anti-mullerian hormone (AMH), a hormone produced by granulosa cells and AGEs in ovulatory and anovulatory PCOS (PCOS-Anov), as well as in non-PCOS anovulatory (Non-PCOS Anov) women.DesignCross-sectional study.MethodsData from sixty women with PCOS (37 anovulatory and 23 regularly ovulating) were compared with eleven Non-PCOS Anov women and 25 normal women. In each subject biochemical, hormonal, and ultrasonographic parameters were studied.ResultsAMH values were statistically significantly higher in PCOS-Anov (7.63±3.12) in comparison with ovulatory PCOS (PCOS-Ov; 4.92±2.50), Non-PCOS Anov (3.66±1.4), and controls (4.02±1.27 ng/ml). AGEs demonstrated a similar pattern: 8.70±1.65 in PCOS-Anov, 7.43±1.79, PCOS-Ov, 5.21±0.09, Non-PCOS Anov, and 5.85±0.89 U/ml in controls (P<0.005 for all comparison respectively). Follicle number was significantly higher in PCOS-Anov in comparison with other groups. A significant positive correlation between AMH and AGEs was observed (r: 0.326,P<0.01), and with the estimated AMH/AGEs ratio to follicle number (r: 0.42,P: 0.0001) and the presence of anovulation.ConclusionsThese data suggest that an oxidative marker, AGEs, and AMH, may interact in the anovulatory mechanisms in women with PCOS.
GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
Authors: Lauffer Lina M. , Iakoubov Roman , Brubaker Patricia L. 
Published: February 2009

OBJECTIVE
Intestinal L-cells secrete the incretin glucagon-like peptide-1 (GLP-1) in response to ingestion of nutrients, especially long-chain fatty acids. The Gαs-coupled receptor GPR119 binds the long-chain fatty acid derivate oleoylethanolamide (OEA), and GPR119 agonists enhance GLP-1 secretion. We therefore hypothesized that OEA stimulates GLP-1 release through a GPR119-dependent mechanism.

RESEARCH DESIGN AND METHODS
Murine (m) GLUTag, human (h) NCI-H716, and primary fetal rat intestinal L-cell models were used for RT-PCR and for cAMP and GLP-1 radioimmunoassay. Anesthetized rats received intravenous or intraileal OEA, and plasma bioactive GLP-1, insulin, and glucose levels were determined by enzyme-linked immunosorbent assay or glucose analyzer.

RESULTS
GPR119 messenger RNA was detected in all L-cell models. OEA treatment (10 μmol/l) of mGLUTag cells increased cAMP levels (P &lt; 0.05) and GLP-1 secretion (P &lt; 0.001) in all models, with desensitization of the secretory response at higher concentrations. GLP-1 secretion was further enhanced by prevention of OEA degradation using the fatty acid amide hydrolase inhibitor, URB597 (P &lt; 0.05–0.001 vs. OEA alone), and was abolished by H89-induced inhibition of protein kinase A. OEA-induced cAMP levels and GLP-1 secretion were significantly reduced in mGLUTag cells transfected with GPR119-specific small interfering RNA (P &lt; 0.05). Application of OEA (10 μmol/l) directly into the rat ileum, but not intravenously, increased plasma bioactive GLP-1 levels in euglycemic animals by 1.5-fold (P &lt; 0.05) and insulin levels by 3.9-fold (P &lt; 0.01) but only in the presence of hyperglycemia.

CONCLUSIONS
The results of these studies demonstrate, for the first time, that OEA increases GLP-1 secretion from intestinal L-cells through activation of the novel GPR119 fatty acid derivate receptor in vitro and in vivo.
A report of 112 cases of solitary rectal ulcer syndrome from Iran
Authors: Derakhshani Saeed , Pakzad Mohsen , Vafaie Mohammad , Tehrani-Tarighat Shirin , Abdollahi Mohammad 
Published: February 2009

Abstract
Solitary rectal ulcer syndrome (SRUS) is a syndrome with symptoms such as rectal bleeding, obstructed defecation, straining at stool and incomplete evacuation, and rectal polyps. In the present study, the clinical features of SRUS among Iranian patients is reviewed. Records of 112 patients diagnosed with SRUS between 1997 and 2007 admitted to a special coloproctology clinic have been analyzed retrospectively. Of 112 patients with SRUS, 61 were male (54.4%) and 51 female (45.6%) with a mean age of 32.2 years (range, 16–64 years). The mean interval between onset of symptoms and final diagnosis of SRUS was 3.8 years (range, 1–14 years). Rectal bleeding (67%) was the most common symptom in both genders, while a feeling of fullness was the least common symptom, observed only in one woman (2%). Incontinence was observed in 4 women (7.8%) and 3 men (4.9%), comprising 6.25% of the total clinical presentations. There were 38 patients (33.9%) with mucosal prolapse and 2 patients (1.8%) with total rectal prolapse. In conclusion, rectal bleeding in the presence of constipation or diarrhea is the main sign for diagnosis of SRUS. This syndrome is usually misdiagnosed; it is frequently confused with inflammatory bowel disease (IBD) because the rectal macroscopic and microscopic lesions and true polyps of rectum are similar. We suggest that most of patients who are treating for IBD and true polyps without any response are suffering from SRUS. Regarding misdiagnosis between SRUS and IBD or rectal polyp, the exact prevalence of SRUS has been mistakenly underestimated.
High-residual platelet activity despite dual antiplatelet treatment associated with subacute stent thrombosis
Authors: Malý Martin , Hadačová Ivana , Hájek Petr , Zemánek David , Veselka Josef 
Published: February 2009

Abstract
High-residual platelet activity despite the dual antiplatelet treatment with aspirin and clopidogrel is associated with major adverse cardiac events, including stent thrombosis. Acute and subacute stent thrombosis is rare, but presents itself with serious complications including high mortality and morbidity rates. Light transmittance aggregometry with specific agonists — arachidonic acid and 5-adenosin diphosphate — is still considered a standard for the assessment of platelet reactivity, besides novel methods like vasodilator-stimulated phosphoprotein phosphorylation. In our case study, we report the coincidence of high-residual platelet activity with subacute stent thrombosis despite the recommended doses of antiplatelet agents — aspirin and clopidogrel. Stent thrombosis was treated by aspiration thrombectomy, and antiplatelet treatment was modified by increasing the dose of aspirin and substituting clopidogrel with a firstgeneration thienopyridin — ticlopidin. The effect of the treatment was documented by reaching the optimal inhibition of platelet reactivity. In the 6- and 12-month follow-up, the patient presented no ischemic events.
Risk factors for breast cancer-related upper extremity lymphedema: Is immediate autologous breast reconstruction one of them?
Authors: Gur Akif , Unal Bulent , Ahrendt Gretchen , Gimbel Michael , Kayiran Oguz , Johnson Ronald , Bonaventura Marguerite , Soran Atilla 
Published: February 2009

Abstract
Breast cancer related upper extremity lymphedema (BCRL) reduces the quality of life of those who have had surgery for breast cancer. The aim of this study is to evaluate the risk factors for BCRL and determine whether immediate autologous tissue breast reconstruction is one of them. A case control study was conducted comparing patients with BCRL (n=97) to surgically treated breast cancer patients without BCRL (control, n=126). The groups were matched for age, type of breast surgery and radiation therapy. Postoperative upper extremity infection, body mass index (BMI), occupation (level of hand-use), and immediate autologous tissue breast reconstruction were investigated as a risk factor of BCRL. Mastectomy was performed on 47.6 % (n=60) and 37.2% (n=36) of patients in the control and the BCRL groups, respectively. Eight patients (13.3%) had immediate autologous tissue breast reconstruction in the control mastectomy group. Six of 36 BCRL patients (16.7%) underwent mastectomy with immediate autologous tissue breast reconstruction. There was no significant difference between groups with respect to incidence or method of immediate reconstruction (p=0.65). Patient occupation (level of hand use) was found to be positively correlated to development of BCRL (p=0.0001). Upper extremity infection rate was 22.7% in the BCRL group and 4.0% in the controls (p=0.0001). The mean BMI in the control and BCRL groups 26.8 kg/m2 and 29.1kg/m2, respectively (p=0.003). In conclusion, in this study characteristics positively associated with development of BCRL included occupation, infection, and increased BMI. Immediate reconstruction of the breast was not found as a risk factor for BCRL. However larger studies are needed, to further evaluate the effect of breast reconstruction on BCRL.
The Neurofibromatosis type 1:A dominantly inherited tumors-predisposing disorder
Authors: Scalzone Maria , Coccia Paola , Ruggiero Antonio , Lazzareschi Ilaria , Mastrangelo Stefano , Riccardi Riccardo 
Published: February 2009

Abstract
Neurofibromatosis type I (NF1) is a hereditary multisystem disease involving the skin and nervous system. It is the most common form of autosomal dominant phakomatoses with 100% penetrance but wide phenotypic variability. The NF1 gene is located on chromosome 17q11.2 and encodes for a tumour suppressor protein. Because affected individuals have an increased risk of tumor formation, this disorder is classified as inherited cancer syndrome. The risk of malignancies in NF1 affected patients is estimated to be 5–15% higher than in the general population. We reviewed clinical aspects and genetic mechanisms of tumorigenesis in NF1 affected patients.
Oxidation of thiophene over copper-manganese mixed oxides
Authors: Szynkowska Małgorzata , Węglińska Aneta , Wojciechowska Elżbieta , Paryjczak Tadeusz 
Published: February 2009

AbstractCommercial hopcalite calcined at different temperatures and hopcalite modified with noble metals (Pt, Pd, and Au) were studied in oxidation of thiophene. Surface and bulk properties of catalysts were studied using temperature-programmed reduction (TPRH2), X-ray diffraction method (XRD) and thermal analysis (TG-DTA-MS). It was shown that calcined samples displayed higher activity in comparison with commercial untreated hopcalite; however, a lower temperature of calcination was favourable. High temperature of thermal treatment induced an increase in the crystallinity and a decrease in the surface area of the samples, and, as a consequence, the loss of catalysts activity. Moreover, marked improvement in the catalytic performance of platinum and palladium modified catalysts in relation to base hopcalite was observed. The obtained results indicate that the higher activity of samples containing Pt and Pd was accompanied by better reducibility of the catalysts.