bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variants of distributed reaction systems
Authors: Csuhaj-Varjú Erzsébet , Vaszil György 
Published: February 2024

AbstractA distributed reaction system consists of a finite set of reaction systems that either interact with a common environment or interact with each other by communicating products or reactions. A reaction system is a well-known qualitative formal model of interactions between biochemical reactions. A reaction is a triplet of nonempty sets representing chemicals, called the set of reactants, the set of inhibitors, and the set of products. A reaction corresponds to a chemical reaction performed on a set of chemicals, and a reaction system is a finite nonempty set of reactions. In this paper, we examine two variants of distributed reaction systems. We introduce the notion of a distributed reaction system with communication by request (a qDRS for short), where sets of products are communicated between the component reaction systems by queries. First, we show that every qDRS can be represented by a reaction system. After that we compare distributed reaction systems with communication by request to extended distributed reaction systems (EDRSs), models that were introduced in a previous paper. We prove that extended distributed reaction systems, where a context automaton provides input for the component reaction systems, simulate distributed reaction systems with communication by request and distributed reaction systems with communication by request simulate special variants of extended distributed reaction systems. Furthermore, we assign languages to these two variants of distributed reaction systems. We prove that the class of agreement languages of extended distributed reaction systems is equal to the class of languages of nondeterministic multihead finite automata and the agreement language of every distributed reaction system with communication by request is an element of a certain subregular language class.
Mapping of Family Reported Outcome Measure (FROM-16) scores to EQ-5D: algorithm to calculate utility values
Authors: Shah R. , Salek M. S. , Finlay A. Y. , Kay R. , Nixon S. J. , Otwombe K. , Ali F. M. , Ingram J. R. 
Published: February 2024

Abstract
Objective
Although decision scientists and health economists encourage inclusion of family member/informal carer utility in health economic evaluation, there is a lack of suitable utility measures comparable to patient utility measures such those based on the EQ-5D. This study aims to predict EQ-5D-3L utility values from Family Reported Outcome Measure (FROM-16) scores, to allow the use of FROM-16 data in health economic evaluation when EQ-5D data is not available.

Methods
Data from 4228 family members/partners of patients recruited to an online cross-sectional study through 58 UK-based patient support groups, three research support platforms and Welsh social services departments were randomly divided five times into two groups, to derive and test a mapping model. Split-half cross-validation was employed, resulting in a total of ten multinomial logistic regression models. The Monte Carlo simulation procedure was used to generate predicted EQ-5D-3L responses, and utility scores were calculated and compared against observed values. Mean error and mean absolute error were calculated for all ten validation models. The final model algorithm was derived using the entire sample.

Results
The model was highly predictive, and its repeated fitting using multinomial logistic regression demonstrated a stable model. The mean differences between predicted and observed health utility estimates ranged from 0.005 to 0.029 across the ten modelling exercises, with an average overall difference of 0.015 (a 2.2% overestimate, not of clinical importance).

Conclusions
The algorithm developed will enable researchers and decision scientists to calculate EQ-5D health utility estimates from FROM-16 scores, thus allowing the inclusion of the family impact of disease in health economic evaluation of medical interventions when EQ-5D data is not available.
Evaluation of the internet-based intervention “Selfapy” in participants with unipolar depression and the impact on quality of life: a randomized, parallel group study
Authors: Schefft Cora , Krämer Rico , Haaf Raoul , Jedeck David , Schumacher Anna , Köhler Stephan 
Published: February 2024

Abstract
Purpose
Depressive disorders cause a major burden of disease worldwide and often lead to a loss of social functioning. Patients suffering from depressive disorders report a lower quality of life (QOL) than people without a history of mental health issues. Internet-based interventions (IBIs) based on cognitive behavioral therapy (CBT) are effective in reducing symptom severity but data on their impact on quality of life in clinically depressed patients so far is scarce.

Methods
Selfapy is a CBT-based IBI for depressive disorders. 401 participants (332 female, mean age 37 (SD = 11) with a diagnosis of major depressive disorder (MDD) or dysthymia were enrolled in a randomized, parallel, three-arm trial comparing a therapist-guided Selfapy intervention with an unguided Selfapy intervention and a waiting list control. QOL was measured using the WHOQOL-BREF at baseline, post-treatment (12 weeks) and at 24-week follow-up. The effects of the interventions on QOL were calculated using linear mixed effects models.

Results
At post-treatment (12 weeks) the guided and unguided intervention groups reported an increase in QOL on physical and psychological health domains compared to controls (significant group*time interaction). The gain in QOL was maintained over the follow-up period only for psychological health. QOL decreased in the social relationships and environment domains over the course of treatment and during the follow-up treatment for all participants. There were no differences between the guided and the unguided intervention.

Conclusion
Selfapy proved to positively affect psychological and physical QOL in a sample of participants suffering from depressive disorders and can therefore be considered an effective and highly scalable therapeutic tool. The pattern of results might partly be attributable to effects of the COVID-19 pandemic and public health measures that coincided with the trial.
Trial registration: German Clinical Trials Register (DRKS): DRKS00017191. Registered June 14th, 2019, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00017191.
Learning from success and failure: implications for entrepreneurs, SMEs, and policy
Authors: Lafuente Esteban , Rabetino Rodrigo , Leiva Juan Carlos 
Published: February 2024

Abstract
Despite the valuable contributions of earlier learning studies, the specific analysis of how entrepreneurs and small- and medium-sized enterprises (SMEs) learn has been sidelined in the literature. Significant research opportunities remain open in various unexplored realms. By adopting a multidisciplinary perspective that combines a variety of frameworks (i.e., organizational, economic, and innovation management), the collection of 11 studies of this special issue dedicated to learning delivers valuable insights into how entrepreneurs and SMEs capitalize on learning processes, while identifying how these processes are affected by the type of experience (i.e., success and failure). This paper first overviews the contributions of the 11 papers included in the special issue. Next, we discuss a number of yet unresolved topics that deserve academic attention, paying special attention to entrepreneurs’ direct and indirect experiences, knowledge obsolescence caused by technology upgrading, and the role of digital technologies—i.e., Internet-of-things and artificial intelligence—in the learning processes.
Updated exploration of the Tor network: advertising, availability and protocols of onion services
Authors: Buitrago López Alejandro , Pastor-Galindo Javier , Gómez Mármol Félix 
Published: February 2024

AbstractThe Tor network is known for its opaque characteristics and involvement in illicit activities, motivating to shed light on the exposure, lifetime, and functionalities of onion services. This study focuses on the appearance of Tor links in online advertising and monitors the connectivity status and protocols of the collected onion domains through the Tor network over 105 days. Out of 54,602 onion addresses gathered, it was found that 38% of Tor links were advertised only once, 43% between two and five times, and 19% more than five times. Furthermore, 50% of the addresses were exclusively advertised on the surface web, 6% on the dark web, and 44% on both portions. The temporal analysis revealed that 67% of the addresses were predominantly active, 7% were intermittent, and 26% were mostly inactive. The study examined fifteen protocols used by onion services, concluding that 94% employed a single protocol, while 6% utilized between two and eight protocols. Among active sites, HTTP was present in 99.75% of cases, followed by SSH (4.95%) and HTTPS (0.64%). Additionally, onion services without web services often deploy cryptocurrency or instant messaging servers. This study offers a comprehensive and current understanding of the dark web, surpassing previous research in its scope.
Benefits and co-benefits of urban green infrastructure for sustainable cities: six current and emerging themes
Authors: Herath Prabhasri , Bai Xuemei 
Published: February 2024

AbstractIntegrating urban green infrastructure (UGI) into cities is receiving increasing attention owing to its potential to provide various urban ecosystem services (UES). This review assesses the multifaceted services of UGI as benefits and co-benefits. By combining systematic and narrative review processes, we aim to synthesise existing knowledge along six current themes and identify research gaps. A total of 690 peer-reviewed articles published during 2000–2020 from Web of Science were selected, followed by bibliometric and full-text analysis. Based on the frequency of appearance in the network visualisation of keywords, six themes of current trends were identified, namely: (1) benefits of UGI as UES; (2) mitigating climate and urban climate impacts by UGI; (3) UGI contribution to sustainable development goals; (4) reconceptualising greenspaces as ‘safe havens’; (5) public acknowledgement and supportive governance for UGI; and (6) rethinking the operationalisability of UGI. The first two themes represent existing focus on categories of ecosystem services, the next two encompass broader emerging co-benefits and the last two focus on how to operationalise UGI and support widespread adoption and implementation. Within Theme 2, the most frequently discussed service with the largest number of research, we conducted a detailed analysis of the methods and content focus in the existing literature. Through a narrative review, we identified 15 research gaps throughout these 6 themes. This review provides a comprehensive overview for urban researchers and practitioners to inform the integration of urban green infrastructure into urban planning and management.
Insight into the significance of Foxp3 + tumor-infiltrating lymphocytes in squamous cell lung cancer
Authors: Shiomi Kazu , Ichinoe Masaaki , Ushiwata Ai , Eshima Koji , Nagashio Ryo , Hayashi Shoko , Sonoda Dai , Kondo Yasuto , Maruyama Raito , Mikubo Masashi , Murakumo Yoshiki , Satoh Yukitoshi 
Published: February 2024

Abstract
Purpose
Although developing a better understanding of tumor-infiltrating Foxp3 + lymphocytes (Foxp3 + TILs) might provide essential knowledge to predict response to immunotherapy and prognosis, our current knowledge about Foxp3 + TILs is inadequate. This study investigated the prognostic significance of tumor-infiltrating Foxp3 + lymphocytes (Foxp3 + TILs) in squamous cell lung cancer (SQ-LC) objectively.

Methods
Among patients with SQ-LC surgically resected in our institution between 2011 and 2017, those with pathological stage IA3-IIIA were immunohistochemically studied to evaluate Foxp3 + TILs in their tumor stroma. The impact of Foxp3 + TILs on relapse-free survival (RFS) was analyzed with Kaplan–Meier survival analysis and multivariate analysis using a Cox proportional hazards model/Fine-Gray model.

Results
This study analyzed 100 patients. Multivariate analysis showed that a large number of Foxp3 + TILs in the stroma does not associate with a poor prognosis, rather that a large number of Foxp3 + TILs (≥ 64 cells) tend to be associated with a more favorable prognosis than a small number of Foxp3 + TILs (< 64 cells) (large vs small number: HR, 0.56; 95% CI, 0.17–1.83; P = 0.34). Exploratory analysis also showed that in the two populations divided by a difference in Foxp3 expression levels, similar trends to the main analysis were observed.

Conclusion
Our results showed that a large number of Foxp3 + TILs in the stroma may not associate with a poor prognosis in SQ-LC. To use the seemingly complicated information of Foxp3 + TILs as biomarkers, better understanding the diversity and heterogeneity of Foxp3 + TILs and analyzing their subpopulations that increase in the TME may be needed.
Prognostic significance of LINC01132 in lung cancer and its regulatory role in tumor progression
Authors: Hu Yang , Wei Youying 
Published: February 2024

Abstract
Background
The application of long non-coding RNAs (lncRNAs) in cancer has been the focus of research in recent years. This study aimed to discuss the expression and functional mechanism of lncRNA LINC01132 (LINC01132) in lung cancer and explore its prognostic significance in tumors.

Methods
The expression of LINC01132 in lung cancer patients was verified using GSE98929 screening and real-time quantitative polymerase chain reaction (RT-qPCR) detection. The prognostic potential of LINC01132 was evaluated by performing the chi-square analysis of clinical indicators, Kaplan–Meier analysis, and Cox proportional hazard model. Cell Counting Kit-8 (CCK-8), flow cytometry, and Transwell assay were used to characterize the biological functions of the lung cancer cells. The targeting relationship between LINC01132 and microRNA-125a-3p (miR-125a-3p), miR-125a-3p and SMAD2 was predicted by bioinformatics and verified by luciferase activity assay.

Results
LINC01132 was upregulated in lung cancer tissues and cells, which was an independent risk factor for survival and prognostic outcomes of lung cancer patients. Silencing LINC01132 suppressed the proliferation and migration of lung cancer cells and accelerated cell death. The target of LINC01132 was miR-125a-3p, and miR-125a-3p inhibitor could eliminate the inhibitory effect of LINC01132 knockdown on the cells. Additionally, SMAD2 is a downstream target of miR-125a-3p, and knockdown of SMAD2 reversed the effects of miR-125a-3p inhibitor on cell migration and invasion.

Conclusion
LINC01132 may regulate the progression of lung cancer by targeting the miR-125a-3p /SMAD2 axis and serve as a prognostic biomarker for lung cancer.
Physico-chemical characterization of food grade natural spring salt from the Central Anatolia region of Turkey and investigation of its microplastic content
Authors: Bozkaya Ogün , Aluç Yaşar 
Published: February 2024

AbstractDelice salt is a natural spring salt obtained from the evaporation of spring water from the Central Anatolia region of Turkey and is a food grade salt with a geographical indication certificate. The aim of this study was to evaluate the compliance of Delice natural spring salt (Delice NSS), a commercial product, with food grade criteria by physicochemical characterizations and to investigate whether it contains microplastics. The NaCl%, moisture suspended solids and acid insoluble matter contents of Delice NSS were analyzed and determined as 98.79% (w/w), 0.301% (w/w), 0.16% (w/w) and 0.01% (w/w), respectively. Sodium, other minerals, and heavy metals were analyzed by inductively coupled plasma-optical emission (ICP-OES) spectrometry. In addition, fluoride, nitrate, and sulphate ions were analyzed by ion chromatography (IC). The chemical and thermal properties of Delice NSS were characterized by FTIR, X-ray fluorescence (XRF) and thermogravimetric analyzer (TGA). Moreover, Delice NSS was investigated whether it contains microplastics and some particles were detected under fluorescence microscopy. However, it was concluded that particles were not microplastics after TGA and FTIR analyses. The results revealed that Delice NSS does not carry a risk in terms of physicochemical properties as a foodstuff.
Learning loss one year after school closures: evidence from the Basque Country
Authors: Arenas Andreu , Gortazar Lucas 
Published: February 2024

AbstractWe use census data on external assessments in primary and secondary schools in the Basque Country (Spain) to estimate learning losses due to the COVID-19 pandemic in March 2021, 1 year after school closures, which lasted from March to June 2020. Differences-in-differences with student and school-by-grade fixed effects show an average learning loss of 0.045 standard deviations, an effect that is smaller than short-run effects estimated by previous papers, and estimated after 6 months of one of the most successful school reopening campaigns among OECD countries. The effect is larger in Mathematics, moderate in Basque language, and none in Spanish language. Controlling for socioeconomic differences, learning losses are especially large in public schools, and also in private schools with a high percentage of low-performing students. On the other hand, we find a regression to the mean within schools, possibly due to a compressed curriculum during the whole period. Finally, and more importantly, we use unique novel data on student socio-emotional well-being and show for the first time that students with higher learning losses self-report significantly worse levels of socio-emotional well-being due to the pandemic.
Upsetting offsetting? Nathan the Wise’s Ring Parable and three reasons why not to adopt the carbon offsetting logic to biodiversity
Authors: Conti Ludovico Giacomo , Seele Peter 
Published: February 2024

AbstractThe climate crisis and the alarming loss of biodiversity require urgent action. One of the most popular tools to tackle these crises is offsetting, an accounting logic through which environmental damages can be compensated elsewhere with environmental benefits. Developed to help address the climate crisis, the carbon offsetting logic has also been transposed to address biodiversity loss. Biodiversity offsets permit the compensation of residual environmental damages through equivalent gains undertaken elsewhere. This article identifies three arguments that show why such a transposition is problematic. To explain the fundamental problem with biodiversity offsetting, the famous Lessing’s “Nathan the Wise” Ring Parable (Ringparabel) is proposed as an allegoric interpretation of the biodiversity offsetting logic, stressing that unique entities lose their uniqueness and power once people try to replicate them.
Long-term changes in herbivore community and vegetation impact of wild and domestic herbivores across Iceland
Authors: Defourneaux Mathilde , Barrio Isabel C. , Boulanger-Lapointe Noémie , Speed James D. M. 
Published: February 2024

AbstractChanges in wild and domestic herbivore populations significantly impact extensive grazing systems, particularly in low productive environments, where increasing wild herbivore populations are perceived as a threat to farming. To assess the magnitude of these changes in Iceland, we compiled time series on herbivore populations from 1986 to 2020 and estimated changes in species densities, metabolic biomass, and consumption of plant biomass in improved lands and unimproved rangelands. We compared estimates of consumption rates to past and present net primary production. Overall, the herbivore community composition shifted from livestock to wildlife dominated. However, wild herbivores only contributed a small fraction (14%) of the total herbivore metabolic biomass and consumption (4–7%), and livestock dominated the overall herbivore biomass. These insights highlight the necessity of developing improved local integrated management for both wild and domestic herbivores where they coexist.
Structural characteristics of the leaves of two species of Tetramerium an endemic to Mexico
Authors: Brechú-Franco Alicia Enriqueta , Laguna-Hernández Guillermo , Velázquez-Mondragón Alejandra , Fonseca-Juárez Rosa María , Espinosa‑Matías Silvia 
Published: February 2024

AbstractIn taxonomic studies, in addition to floral characteristics, the structural characteristics of the vegetative organs also contribute to the taxonomic determination of the species. To provide information regarding these characteristics in the genus Tetramerium, a structural, micromorphological and histochemical analysis of cross sections of the leaves was performed using histochemical techniques and optical and scanning electron microscopy of two of its species, T. glutinosum, endemic to Mexico, and the widely distributed T. tenuissimum, was conducted. The two species presented amphistomatic leaves; double palisade chlorenchyma on adaxial and abaxial surfaces, leaf unifacial; vascular bundle sheaths with kranz anatomy; intradermal and subepidermal cystoliths of various shapes and sizes; nonglandular trichomes osteolate with a thin-walled conical head, glandular trichomes, including a new type, the straight, bright-ringed tricellular trichomes, and a variety of multicellular glandular trichomes. The glandular trichomes secrete waxes or oleoresins and mucilage deposited on the surfaces abaxial and adaxial in the form of platelets, granules and threads or strands. The histochemistry of the cystoliths highlights the presence of proteins and polysaccharides as a product of the possible superposition of the cell wall and plasmalemma lamellae. All these characteristics are typical of species from semi-arid habitats and correspond to the defense function against biotic and abiotic agents assigned to trichomes and their secretions in other studies of various genera and families, as well as to the adaptation function to these habitats of the kranz structure, which was novel for the genus Tetramerium.
The Spatiotemporal Evolution Mechanism of Urban Rail Transit Fault Propagation in Networked Operation Modes
Authors: Xiaobing Ding , Hua Hu , Zhigang Liu , Qingquan Mu 
Published: February 2024

AbstractThe cascading propagation and evolution of metro operation failures can significantly impact the safety of metro operation. To overcome this challenge, this study pre-processes a massive amount of metro operation log data through noise reduction. Moreover, a professional terminology dictionary is constructed along with a custom stop-word dictionary to segment the preprocessed data. Subsequently, the AFP-tree algorithm is employed to mine the segmented log data and identify key hazards. A weighted urban rail transit network is established, considering the effective path time cost, and the shortest travel OD path. To simulate the dynamic evolution of the failure chain propagation, a model based on disaster propagation theory is constructed. Taking the Shanghai Metro line as a case, multiple simulation scenarios are established with 25 key hazards as triggering points, and the number of cascade failure stations affected under different scenarios is outputted. The results indicate that the fault stations caused by the large passenger flow are the largest. Meanwhile, the number of stations affected by the door clamp is the smallest. The scale of fault stations reaches a maximum value in 16–20 min. Through case analysis, a positive correlation is found when the self-recovery factor is between 14 and 18, and the number of fault stations shows a significant increasing trend. The research results can provide decision-making support and theoretical guidance for rail transit operation safety management enterprises.