bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social learning-based health literacy promotion on the self efficacy and social anxiety of adolescents with type 1 diabetes
Authors: Begjani Jamalodin , Hosseini Akram Sadat Sadat , Saneifard Hedieh , Hasanabad Vida Rahimi 
Published: March 2024

Abstract
Background and objective
Type 1 diabetes mellitus one of the biggest health concerns around the world, is difficult to manage during adolescence. Among the non-medical methods of controlling this disease is empowerment through self-efficacy. Poor self-efficacy leads to social anxiety and ultimately deficiencies in diabetes. There is also a correlation among health literacy, self-efficacy, and social anxiety. Thus, the present study aimed to evaluate the impact of a literacy promotion training program based on social learning theory on the self-efficacy and social anxiety of adolescents with T1DM.

Methods
The current research is a semi-experimental type that was carried out with the cooperation of 66 adolescents aged 15–18 years with type 1 diabetes in Iran (Tehran, 2022). It has control and intervention groups. The endocrinology and diabetes clinics of the intervention and control groups were randomly selected in a multi-stage manner (endocrine and diabetes clinic of children’s medical center hospital for the control group and endocrine and diabetes clinic of Mofid hospital for the intervention group) and the participants were selected by Simple Random Sampling method (draw). The training program designed based on Bandura’s social learning theory was used to teach adolescents during seven consecutive sessions of 30–45 min during one week. Questionnaires were completed before and one month after the intervention. Data were analysed in SPSS-25 software.

Findings
The intervention for adolescents with T1DM in intervention group compared to the control group had a significant effect on improve health literacy (P<0.001), self-efficacy (P<0.001), and social anxiety (P<0.05).

Conclusions
The results can also be used to improve the capabilities of adolescents with T1DM, reduce and prevent disease complications, and develop operational-educational programs in the centers from which these adolescents receive various services.

Trial registration
IRCT20210422051045N1.
Diagnostic utility of renal shear wave elastography and renal Doppler findings in diabetic nephropathy: a case–control study
Authors: Baz Ahmed Abdelrahman , Abdeen Eman Muhammad , Helmy Mona Yousry , Al-Bohy Abo El-Magd 
Published: March 2024

AbstractBackgroundDiabetes mellitus is a common systemic disease that affects the kidneys and could eventually develop an end-stage renal failure. Renal biopsy is considered a gold standard for histological characterization of diabetic nephropathy, of which renal fibrosis is a dominant component, affecting its stiffness. The objective of this study is to investigate a correlation between renal stiffness obtained by shear wave elastography, renal Doppler resistivity indices, laboratory findings, and the histological characterization depicted by renal biopsies (if feasible) in diabetic nephropathy patients and to compare their results with those obtained from normal population to explore the diagnostic efficacy of shear wave elastography. Shear wave elastography and color duplex US were performed in twenty-six diabetic nephropathy patients and twenty-six healthy (age and sex-matched) control subjects. The shear wave elastography-derived mean value of the renal tissue stiffness was measured (in kilopascals) as well as the resistivity indices of segmental renal arteries, and then the mean values were correlated to patients' clinical-laboratory data (serum creatinine and albumin/ creatinine ratio) and the biopsy results, if feasible.ResultsA significant positive correlation was found between the mean resistivity indices and the mean renal cortical stiffness at one hand and the patients' clinical-laboratory data with statistically significant differences found between the control, early, and late stages of diabetic nephropathy.ConclusionsShear wave elastography is a promising, non-invasive, and accurate diagnostic tool for assessment and differentiation between early and late stages of diabetic nephropathy with a significant positive correlation to the clinical-laboratory and renal Doppler findings.
Vitamin D and the microbiota connection: understanding its potential to improve COPD outcomes
Authors: Ali Asmaa , Wu Liang , Ali Sameh Samir 
Published: March 2024

AbstractThe mucosa of the respiratory system is an essential site for local vitamin D synthesis, degradation, and signaling. It modulates the inflammatory and immune response by saving the integrity of the mucosal barrier and killing the invading pathogen through the induction of antimicrobial peptides. The proper functioning of the immune system within the respiratory system is influenced by the complex interactions of numerous immune pathways, including the gut-lung axis. Recent research has indicated that the gut microbiota is vital in developing and progressing chronic inflammatory chest conditions, such as asthma and chronic obstructive pulmonary disease (COPD). Furthermore, the immune-modulating function of vitamin D operates through the gut mucosa; hence, the vitamin D receptor is expressed to regulate the antimicrobial peptide. The potential protective role of vitamin D and its correlation with COPD has garnered significant interest. It is currently under exploration as a possible adjuvant therapy to aid in managing frequent exacerbation of COPD. In this review, we explored the connection between vitamin D and the immune system, as well as its relationship with microbiota. We also summarized some novel mechanisms of action of vitamin D supplementation that can impact disease exacerbation.
Farm animals as a critical link between environmental and human health impacts of micro-and nanoplastics
Authors: Aardema Hilde , Vethaak A. Dick , Kamstra Jorke H. , Legler Juliette 
Published: March 2024

AbstractPlastic pollution is an increasing global health concern, particularly the ever-increasing amount of tiny plastic particles commonly referred to as micro- and nanoplastics (MNPs). Most research to date on MNP exposure and hazards has focused on environmental species such as aquatic organisms and, more recently, humans, leaving impacts on farm animals largely unstudied. MNPs have been detected in all environmental compartments, including agricultural environments, farm animals and food products originating from them. The health of farm animals can be directly affected by MNPs, while humans can be affected by MNPs present in animal-derived food products. In this perspective article, we argue that MNP research should give more attention to farm animals forming a critical link between the environment and human health. Here, we summarize evidence on sources, exposure routes, levels in farm animals, and potential health effects of MNPs on farm animals, and identify knowledge gaps for future research, such as effects of MNPs on reproduction and development. In particular, the bovine embryo model is a promising model to study effects of MNPs on early development of both farm animals and humans. This perspective article signals the need for follow up studies that will increase our understanding of the transfer of MNPs between environment, farm animals, and humans, and the potential of farm animals to serve as an indicator for other animals, including humans.
Plastics in biota: technological readiness level of current methodologies
Authors: Vanavermaete David , Lusher Amy , Strand Jakob , Abad Esteban , Farré Marinella , Kallenbach Emilie , Dekimpe Michael , Verlé Katrien , Primpke Sebastian , Aliani Stefano , De Witte Bavo 
Published: March 2024

AbstractPlastics are persistent in the environment and may be ingested by organisms where they may cause physical harm or release plastic additives. Monitoring is a crucial mechanism to assess the risk of plastics to the marine and terrestrial ecosystem. Unfortunately, due to unharmonised procedures, it remains difficult to compare the results of different studies. This publication, as part of the Horizon project EUROqCHARM, aims to identify the properties of the available analytical processes and methods for the determination of plastics in biota. Based on a systematic review, reproducible analytical pipelines were examined and the technological readiness levels were assessed so that these methods may eventually (if not already) be incorporated into (harmonised) monitoring programs where biota are identified as indicators of plastic pollution.
Experimental study on the mechanical properties and structural performance of the rapid hardening concrete
Authors: Elfakhrany Mohamed Hussein , Zamrawi Amal , Ibrahim Wael , Sherif Alaa 
Published: March 2024

AbstractRapid-hardening concrete (RHC) is becoming more popular as a cast-in-place jointing material in precast concrete bridges and buildings due to its high tensile strength and crack resistance. RHC’s technical properties are highly regarded due to the working conditions of mega projects. The study assessed the impact of modern modifiers on concrete in order to select a composition of rapid-hardening concrete (RHC) with superior mechanical properties. Following an analysis of previous studies by other authors, microsilica and a polycarboxylate ether-based chemical additive was chosen as basic modifiers in the manufacture of RHC. In addition, four reinforced rapid-hardening concrete beams were tested for operational reliability and durability after 3 days of casting. The structural performance of RHC beams was evaluated in comparison to normal concrete beam specimens, and it was determined that crack distribution, load deflection, reinforcement strains, ductility, and toughness were all important factors in the evaluation. RHC beams exhibit higher ductility, toughness, ultimate loads, and deformability than NC beams. The tensile strength analysis revealed a positive impact of RHC, but the shrinkage crack related to heat hydration was crucial.
Investigating the Association of Polygenic Risk Scores With Thyroid Cancer Susceptibility in a Han Chinese Population
Authors: Chen Yi-Hao , Chen I Chieh , Chou Chia-Man , Huang Sheng-Yang 
Published: March 2024

Abstract

Background
Thyroid cancer, the leading endocrine tumor with a rising global incidence, especially in women, is influenced by both genetic and environmental factors. This study examines the relationship between polygenic risk scores (PRS) and thyroid cancer susceptibility in the Han Chinese population, as well as the impact of genetic variants on clinical outcomes.

Methods
Analyzing data from 57 257 participants in the Taiwan Precision Medicine Initiative, the study employed the Affymetrix Genome-Wide TWB 2.0 SNP Array for genotyping. PRS were calculated using single nucleotide polymorphisms (SNPs) from prior genome-wide association studies, specifically PGS000087 and PGS000797, and correlated with clinical parameters like age, sex, comorbidities, and treatment methods.

Results
Among 4063 participants with thyroid tumors (839 malignant, 3224 benign), higher PRS quartiles correlated significantly with increased thyroid cancer incidence. The highest quartile showed a 1.15-fold (PGS000797) and 1.14-fold (PGS000087) greater risk than the lowest quartile. Key findings included an association between higher PRS quartiles and younger onset age, along with a notable link to chronic kidney disease and thyroid hormone levels in specific SNPs.

Conclusion
The study demonstrates PRS's utility in predicting thyroid cancer risk in the Han Chinese population, with higher PRS associated with increased risk and distinct clinical features. While this study focuses on the Han Chinese population, we recognize the importance of comparing PRS performance across different ancestries to fully understand ethnic genetic diversity in cancer risk assessment. Future studies should aim to include such comparative analysis.
101 Glymphatic System Impairment Associated With Neurocognitive Dysfunction and Alzheimers Biomarkers in Moyamoya Disease
Authors: Zeng Chaofan , Zhai Yuanren , Ge Peicong , Zhang Dong , Zhao Jizong 
Published: March 2024

INTRODUCTION:
Glymphatic system alterations have been proved to be associated with cognitive dysfunction in Alzheimer’s Disease (AD). The glymphatic pathway has not been elucidated in moyamoya disease (MMD), which was recognized as a chronic hypoperfusion model for AD.

METHODS:
We prospectively recruited 30 MMD patients and 30 matched healthy controls (HC) from October 2022 to March 2023. Participants underwent neurocognition evaluation, and multimodal magnetic resonance imaging (MRI). AD-related serum biomarkers, as well as correlations among these variables were examined. The glymphatic function was assessed by diffusion tensor image analysis along perivascular space (DTI-ALPS). Whole-brain (white matter and grey matter) volumes were calculated by using 3D T1-weighted MRI. Microstructural changes of white matter (intracellular volume fraction, Vic; orientation dispersion index, OD) were evaluated by neurite orientation dispersion and density imaging (NODDI).

RESULTS:
Serum Alzheimer’s biomarkers (ApoE, Aβ40, Aβ42, and tau) were significantly elevated and associated with neurocognitive dysfunction in MMD. Lower periventricular ALPS-index was identified in patients with MMD (P < 0.001). The decreased ALPS-index correlated with declined neurocognitive performance of intelligence quotient, attention, and memory, increased levels of serum ApoE, Aβ40, Aβ42, as well as higher periventricular white matter volume and lower periventricular grey matter volume (P < 0.001). Moreover, MMD patients had significantly lower Vic in the white matter and a lower OD in the cortex than HC.

CONCLUSIONS:
We firstly demonstrated the impaired glymphatic system as assessed by lower ALPS-index in patients with MMD. Glymphatic impairment was associated with AD-related biomarkers and cognitive dysfunction in MMD. These findings suggested that glymphatic disorder may interact with MMD-related pathophysiological processes.
1066 Comparative Outcome Using Expandable Versus Static Cage in Direct Lateral Interbody Fusion for Degenerative Lumbar Disc Disease
Authors: Chieng Lee-Onn , Kanyadike Kim , Chehab Moussa 
Published: March 2024

INTRODUCTION:
Subsidence has been a common concern or complication in patients undergoing TLIF with an expandable cage or standalone DLIF with a static cage. It could lead to further complications such as pseudoarthrosis, lumbar kyphosis, and radiculopathy. Recently, expandable technology has emerged in lateral interbody fusion, which could be delivered through the smaller surgical corridors. Therefore we sought to determine the extent of radiological outcome and subsidence rate in patients with expandable cages.

METHODS:
A retrospective review of patients who underwent DLIF was performed. Only patients with degenerative lumbar disc disease were included. Baseline demographic and radiographic outcomes such as cage subsidence, anterior and posterior disc height, foraminal dimensions, and other spinopelvic parameters were collected. The primary endpoint was severe cage subsidence (grade 2 and 3) per level according to the classification by Marchi et al. Multivariate Analysis was performed.

RESULTS:
59 patients underwent DLIF with expandable (n = 25) and static (n = 34) cages respectively. Both expandable and static groups have comparable baseline demographic such as age, gender, BMI, and medical comorbidities. The average follow-up period was 16 months. Both groups also had a comparable rate of the standalone construct (40% vs 68%, p 0.088). Significant higher cage width and length were used in the expandable group. However, there were no statistically significant differences in the restoration of both anterior and posterior disc heights, foraminal height, and central canal diameter. A significantly lower rate of severe subsidence was observed in the expandable group (4% vs 26.5%, p = 0.023) compared to the static group.

CONCLUSIONS:
In our study, expandable cages in DLIF patients were observed to have a significantly lower rate of subsidence when compared to those who received static cages.
1070 Muscle Mechanomyography (MMG) for Peripheral Nerve Monitoring During Lateral Lumbar Fusion: The New Kid on the Block?
Authors: Chine Angel Gabriel , Pressman Elliot , Monsour Molly , Alikhani Puya 
Published: March 2024

INTRODUCTION:
The lateral transpsoas approach has become a valuable minimally invasive option in lumbar spine surgery to achieve fusion, decompression, and deformity correction. However, femoral nerve injury during psoas retraction remains a significant concern, especially in the lower spinal levels. A newer alternative to electromyography (EMG), muscle mechanomyography (MMG) measures muscle fiber oscillation during contraction, providing a more specific and quantifiable response with a high signal to noise ratio. These characteristics make MMG an attractive option for intraoperative neuromonitoring (ION) in minimally invasive spine surgery.

METHODS:
Patients who underwent LLIF between 2018-2021 with MMG ION were included and compared to a historical cohot of patients who underwent LLIF from 2016-2021 with EMG ION. The femoral nerve palsy rate defined by ipsilateral thigh numbness, hip flexor, or quadricep weakness immediately post operatively were collected for both groups. Patients were re-evaluated at 3 month and 1 year follow up intervals.

RESULTS:
The rate of ipsilateral thigh numbness, hip flexor, and quadricep weakness at hospital discharge were 14.6% (6/41), 9.8% (4/41), and 7.3% (3/41) respectively for the MMG group, comparable to 14.8% (9/61), 23% (14/61), and 14.8% (9/61) observed in the EMG control group. Improvement in thigh numbness and leg weakness was observed for both groups at 3 month and 1 year follow up. No patients with leg weakness had less than antigravity strength. There were no statistically significant difference amongst patient demographics for both cohorts.

CONCLUSIONS:
In conclusion, MMG appears to be clinically equivalent to EMG as an intraoperative modality for femoral nerve monitoring in LLIF procedures. Further research is needed to evaluate the additional clinical advantages proposed by mechanomyography, such as low signal interference and quantifiable nerve localization.
1071 Initial Experience Using an Augmented Reality Head-Mounted Display System During Surgical Management of Thoracolumbar Spinal Trauma
Authors: Kann Michael , Ruiz-Cardozo Miguel A. , Brehm Samuel , Carey-Ewend Abigail , Singh Som , Barot Karma , Verastegui Gabriel Trevino , De La Paz Matthew , Hanafy Ahmed , Bui Tim , Joseph Karan , Olufawo Michael O. , Sanchez Paula Alejandra , Patel Rujvee , Yahanda Alexander T. , Perdomo-Pantoja Alexander , Jauregui Julio , Cadieux Magalie , Pennicooke Brenton Henry , Molina Camilo A. 
Published: March 2024

INTRODUCTION:
Advancements in trauma medicine can improve the speed and accuracy of care response with a major impact on downstream operative outcomes. Augmented reality using a head-mounted-display (AR-HMD) is a novel technology that may be applied to spine surgery to provide surgeons with a real-time CT-guided 3-dimensional reconstruction of a patient’s spinal anatomy.

METHODS:
We retrospectively reviewed trauma patients who underwent pedicle screw placement guided by AR-HMD or robotic-assisted platforms at an academic tertiary care center between January 1, 2021 and December 31, 2022. Demographic, clinical, cost, and perioperative outcome information was analyzed and outcome profiles were compared using a U test.

RESULTS:
The AR cohort (4 females, 5 males) had a mean age of 66.0 years, BMI of 29.4 kg/m2, Charlson Comorbidity Index (CCI) of 4.11, and Surgical Invasiveness Index (SII) of 8.78. Pedicle screws (77) were placed in the thoracic (51%), lumbar (39%), and sacral spine (10%). Intraoperatively, there was a mean blood loss of 377.78 ml, 0.78 units transfused, 398.33 minutes spent in the operating room, and a 20.00 day LOS. The average 3-month, 6-month, and 12-month ODI scores were 14.25 (n = 8), 15.40 (n = 5), and 12.66 (n = 3). The robotic cohort (5 females, 8 males) had a mean age of 55.6 years, BMI of 27.1 kg/m2, CCI of 3.77, and SII of 14.23. Pedicle screws (128) were placed in the thoracic (59%), lumbar (37%), sacral spine (2%), iliac spine (2%), and pelvis (2%). Intra-operatively, there was a mean blood loss of 431.54 ml, 0.46 units transfused, 330.61 minutes spent in the operating room, and a 10.38 day LOS. The average 3-month, 6-month, and 12-month ODI scores were 22.67 (n = 9), 18.60 (n = 5), and 29.50 (n = 2).

CONCLUSIONS:
This case series demonstrates the utility of AR-HMD in surgical spinal trauma cases by showing operative outcomes comparable to those observed in robotic-assisted surgery.
1076 3-Level ACDF Versus 3-Level Laminectomy and Fusion: Are There Differences in Outcomes? An Analysis of the QOD CSM Cohort
Authors: Kai-Hong Chan Andrew , Ambati Vardhaan Sai , Macki Mohamed , Michalopoulos Giorgos , Le Vivian , Jamieson Alysha , Chou Dean , Shaffrey Christopher I. , Gottfried Oren N. , Bisson Erica Fay , Asher Anthony L. 
Published: March 2024

INTRODUCTION:
Prior studies comparing anterior versus posterior approaches for multilevel cervical spondylotic myelopathy (CSM) are limited by the heterogeneity of levels operated.

METHODS:
The prospective QOD CSM cohort was queried for fusions across only three interspaces. Surgeries crossing the cervicothoracic junction were excluded. The cohort was divided into anterior cervical discectomy and fusion (ACDF) and posterior laminectomy-and-fusion. 24-month patient-reported outcomes were compared.

RESULTS:
Of 199 patients (123 ACDF, 76 posterior fusions), 24-month follow-up rates were similar (ACDF: 90.2% vs. 92.1%, p = 0.67). Preoperatively, ACDF were younger (60.8 ± 10.2 vs. 65.0 ± 10.3 yr, p < 0.01), used more private insurance (56.1% vs. 36.8%, p = 0.02), were more often employed (39.8% vs. 22.8%, p = 0.04), and independently ambulatory (14.6% vs. 31.6%, p < 0.01). Otherwise, the cohorts had equivalent baseline mJOA, NDI, NRS Arm-Pain, NRS Neck-Pain, and EQ-5D (p > 0.05). ACDF had shorter hospitalizations (1.6 vs. 3.9 days, p < 0.01) and less non-routine discharge (7.3% vs. 22.8%, p < 0.01) but higher postoperative dysphagia (13.5% vs. 3.5%, p = 0.049). Both groups demonstrated improvements in all outcomes at 24 months (p < 0.05). In multivariable analyses, ACDF was associated with the greatest 24-month NASS Satisfaction (NASS 1)(69.4% vs. 53.7%, OR = 2.44, p = 0.02). Otherwise, the cohorts shared similar 24-month patient-reported outcomes. There were no differences in 3-month readmission (4.1% ACDF vs. 3.9% posterior fusion, p = 0.97) and 24-month reoperation rate (13.5% ACDF vs. 18.6% posterior fusion, p = 0.36).

CONCLUSIONS:
In a cohort limited to 3-level surgeries, ACDF was associated with reduced blood loss, shorter lengths of hospitalization, and higher routine discharge rates; however, posterior cervical fusion resulted in less dysphagia. After controlling for confounders, the ACDF cohort had a significantly higher odds of maximum satisfaction. Patients should be counseled on the risks and benefits of each approach, given relatively comparable outcomes.