bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. IV. examination of tissues and fluids for infectious agents
Authors: Sharp John T. , Waksman Byron H. , Pearson Carl M. , Madoff Sarabelle 
Published: February 2007

AbstractAdjuvant induced arthritis is believed to be due to an immunological process associated with the development of delayed hypersensitivity to a component of the injected mycobacterial adjuvant. However, since pleuropneumonia‐like organisms (PPLO) may cause arthritis in rats, it was necessary to determine whether such microorganisms play any role in adjuvant disease. This article reports attempts to cultivate bacteria and PPLO from affected tissues and to transfer disease to normal recipients. No evidence for an infectious agent was obtained.
A study of the prevalence of arthritis in alaskan eskimos
Authors: Blumberg Baruch S. , Bloch Kurt J. , Black Roger L. , Dotter Charles 
Published: February 2007

AbstractRheumatoid arthritis is present in an Alaskan Eskimo population. The prevalence of X‐ray evidence of osteoarthritis of the hands and wrists has been determined in an Eskimo population. Comparison with available U. S. white data suggests that the prevalence may be lower in the Eskimo. There was a high prevalence of individuals in the village of Wainwright whose sera yielded a positive bentonite flocculation test.
Studies of the rabbit antibodies which sensitize red blood cells for agglutination by rheumatoid factors
Authors: Rockey John H. , Kunkel Henry G. 
Published: February 2007

AbstractThe high and low molecular weight antibodies of rabbit antisheep red cell serum were separated by electrophoresis, density gradient ultracentrifugation, and DEAE chromatography. It was demonstrated that only antibodies of the low molecular weight class were able to sensitize cells in subagglutinating titer for agglutination by rheumatoid factors. High molecular weight antibodies lacked this capacity. The roles of incomplete rabbit antirabbit red cell and antisheep red cell antibodies in sensitization is discussed.
The Isohemagglutinin partition in rheumatoid arthritis
Authors: Rawson Arnold J. , Abelson Neva M. , McCarty Daniel J. 
Published: February 2007

AbstractFollowing stimulation with incompatible blood group substance, group O rheumatoids have consistently lower isohemagglutinin liters than do normal subjects of the same blood group. This is believed to reflect a decrease in activity associated with S7 globulins. The abnormality does not appear to be the result of steroid therapy and is not seen in sarcoid, cirrhosis, gout or systemic lupus erythematosus.
Immunologic manifestations of a group of patients with a diagnosis of discoid lupus erythematosus
Authors: Bennett J. Claude , Osment Lamar S. , Holley Howard L. 
Published: February 2007

AbstractSerologic methods currently in use for the study of systemic L.E. offer a possible means for early identification of that proportion of patients with a diagnosis of discoid L.E. who may develop generalized manifestations. Use of these methods in a group of sixteen patients with a diagnosis of chronic discoid L.E. reveals that some patients with only skin abnormalities may be found to have subtle immunopathologic manifestations which are strongly suggestive of the systemic disease.
Zoxazolamine As a Uricosuric Agent. I. Acute Effects in Healthy Non‐Gouty Subjects
Authors: Reed Elizabeth B. , Feichtmeir Thomas V. , Craig Shirley G. 
Published: February 2007

AbstractThe increase in urate clearance during a six hour period following ingestion of zoxazolamine by healthy non‐gouty subjects is roughly proportional to the dose over the range of 25 mg. to 250 mg. The uricosuric activity of zoxazolamine was not affected by concomitant administration of a number of other drugs, but was enhanced by probenecid and by sulfinpyrazone and was diminished by acetazolamide and by small amounts of salicylate.
Coalescence of caudal vertebrae in the giant dinosaur Diplodocus
Authors: Blumberg Baruch S. , Sokoloff Leon 
Published: February 2007

AbstractThe coalescence, seen frequently in the caudal vertebrae of the giant dinosaur Dipiodocus longus, has been re‐examined. A comparison with vertebral fusion in contemporary species suggests that the changes in the dinosaur were of traumatic rather than rheumatoid type.
The resection angulation operation in the treatment of the painful or stiff hip
Authors: Milch Henry 
Published: February 2007

AbstractThe resection angulation operation is designed to eliminate the pain while preserving stabile mobility in the various coxarthroses. Although it may be completed at a single sitting, this operation is a combination of two separate procedures: (1) a resection of the femoral head and neck which serves to decompress the diseased acetabulum and releases the femur at the hip joint, and (2) an abductional Schanz type of femoral osteotomy which serves to restore hip stability. The procedure is technically simple and with attention to its details will yield relief of pain in more than 90 per cent and improvement in motion in over 70 per cent of all cases of painful hip limitation regardless of etiology.
Rheumatoid arthritis of the cricoarytenoid joint: A clinicopathologic study
Authors: Bienenstock Harry , Ehrlich George E. , Freyberg Richard H. 
Published: February 2007

AbstractArthritis of the cricoarytenoid joint occurs much more frequently in patients with rheumatoid disease than has generally been suspected. Seventeen of 64 randomly selected patients with rheumatoid arthritis had one or more symptoms considered to be characteristic of cricoarytenoid arthritis. At postmortem examination, histopathologic changes typical of rheumatoid arthritis were seen in the cricoarytenoid joints in seven of eight patients with rheumatoid arthritis. The abnormal findings on indirect laryngoscopy, typical of rheumatoid arthritis of the cricoarytenoid joints, are reported and treatment is discussed.
Nodular rheumatoid disease of the lung with cavitation
Authors: Noonan Charles D. , Taylor Fletcher B. , Engleman Ephraim P. 
Published: February 2007

AbstractNodular rheumatoid disease of the lung is an established clinical entity, having been recorded previously in 14 cases. The 14 cases were reviewed, with emphasis on their differentiation from nodular lung disease associated with pneumoconiosis and rheumatoid arthritis (Caplan's syndrome). This report adds a fifteenth case to the literature with the characteristics of the second recorded instance of roentgenologically demonstrable cavitation of pulmonary nodules, an associated high F‐II titer, and a silica‐free biopsy specimen.
Effect of aspirin on circulatory responses to catecholamines
Authors: Strom Esther A. , Coffman Jay D. 
Published: February 2007

AbstractCalf and foot blood flow responses to intravenous epinephrine and norepinephrine were studied by venous occlusion plethysmography. Subjects were studied on two control days and after having ingested 3.6 gms. aspirin daily for two days. Epinephrine‐induced vasoconstriction in the foot and vasodilation in the calf were significantly reduced after aspirin as was norepinephrine‐induced vasoconstriction in both the foot and the calf. Skin temperatures confirmed the reduction of cutaneous vasoconstrictor responses by aspirin. Pulse and blood pressure responses were unaffected.
Gamma‐1 globulin levels in rheumatic fever
Authors: Hong Richard , West Clark D. 
Published: February 2007

AbstractGamma‐1A serum levels were found to be elevated in 74 per cent of 31 cases of acute rheumatic fever, more frequently than in rheumatoid arthritis, acute glomerulonephritis, and non‐complicated streptococcal infections. Some patients with clinically inactive rheumatic fever also demonstrated increased gamma‐1A. This finding could not be correlated with the severity of cardiac damage nor was it associated with continuing clinically inapparent activity. Surprisingly, gamma‐ 1M increase was observed in only 13 per cent of the cases.
Findings suggestive of systemic lupus erythematosus in subjects on chronic anticonvulsant therapy
Authors: Wilske Kenneth R. , Shalit Ivan E. , Willkens Robert F. , Decker John L. 
Published: February 2007

AbstractAn institutionalized population was examined under standardized conditions for physical and laboratory abnormalities seen with systemic lupus erythematosus or other connective tissue diseases. Multiple abnormalities were found in about 8 per cent of those on chronic anticonvulsant therapy and in none of those not receiving such treatment; phenobarbital was as closely related as diphenylhydantoin but the combination may be most important. The abnormalities were interpreted as reactive results of the drugs; the ability to react was considered to be restricted to a small proportion of the population.
The inflammatory response to injected microcrystalline monosodium urate in normal, hyperuricemic, gouty and uremic subjects
Authors: Buchanan W. Watson , Klinenberg James R. , Seegmiller J. E. 
Published: February 2007

AbstractMicrocrystalline sodium urate was injected intradermally and subcutaneously in 15 normal subjects, 12 hyperuricemic subjects without gout, 14 patients with gout and 6 uremic subjects, and the magnitude of the inflammatory response was determined. The skin reactivity was markedly diminished in 4 of the 6 uremic patients. The range of skin reactivity was significantly greater in gouty patients than in normal or hyperuricemic subjects, but there was no significant difference in the mean inflammatory response between these groups of subjects.
Movement and composition of interstitial fluid of cartilage
Authors: Linn Frank C. , Sokoloff Leon 
Published: February 2007

AbstractA method is described for determining the rate of mechanical expression and resorption of fluid from cartilage and for determining its composition. Human articular cartilage, unlike costal tissue, showed little change in its total or expressible fluid throughout life. The extruded material resembled synovial fluid except for its low protein content and viscosity. It is suggested that the expressed fluid was held osmotically in the ground substance.
The effects of indomethacin on rheumatic fever
Authors: Vignau Alberto , Guasch Julio , Schuster Augusto , Patri Alfredo , Correa Enrique , Vaisman Samuel , Mortimer Edward A. 
Published: February 2007

AbstractIndomethacin, a non‐steroid anti‐inflammatory drug, was given to 28 patients with acute rheumatic fever or chorea, and its effects compared to 23 similar patients given aspirin. No significant differences were observed either in effects on acute phase manifestations or the incidence of valvular heart disease one year later. Because of the incidence of side effects in other studies, indomethacin would appear to offer no advantage over aspirin in the therapy of rheumatic fever.
Colchicine and trimethylcolchicinic acid: A comparison of their effects on human white blood cells in vitro
Authors: Wechsler Robert , Wallace Stanley L. , Gerber Donald , Schrrer Joseph 
Published: February 2007

AbstractColchicine suppressed acid production by human leukocytes during phagocytosis in vitro, while trimethylcolchicinic acid did not. Since the two substances are similar chemically and in their effect on gout, one may conclude that colchicine does not exert its beneficial effect on acute gout by means of its suppression of leukocyte acid production during phagocytosis. In addition, trimethylcolchicinic acid was shown to have no antimitotic effect in the concentration tested.
Rheumatoid Arthritis After Rubella
Authors: Martenis Thomas W. , Bland John H. , Phillips Charles A. 
Published: February 2007

AbstractA case of rheumatoid arthritis following rubella is presented. The serum latex fixation test, at first negative, became positive in high titer in 2 months and was positive 5 years after onset of the arthritis. Convalescent sera were positive for rubella neutralizing and hemagglutination‐inhibiting antibodies through the 5‐year follow‐up. Although the association could be coincidental, these findings suggest that rubella virus may have contributed to the subsequent development of the syndrome of rheumatoid arthritis.
Pulmonary Involvement in Polymyositis: Report of a Case with Response to Corticosteroid Therapy
Authors: Weaver Arthur L. , Brundage Bruce H. , Nelson Roald A. , Bischoff Marshall B. 
Published: February 2007

AbstractA case of polymyositis with clinical, roentgenologic, physiologic, and morphologic evidence of lung involvement has been presented. The initial description of the electron microscopic alterations of the pulmonary lesions has been included. Symptomatic improvement and resolution of the roentgenographic abnormalities followed corticosteroid therapy. The similarity of the pulmonary lesions occurring in polymyositis and progressive systemic sclerosis has been stressed; the response of the former to corticosteroid therapy may be a possible differentiating feature.
Immunologic and clinical observations of granulocyte‐specific antinuclear antibodies
Authors: Svec Kathryn H. 
Published: February 2007

AbstractThe presence of granulocyte‐specific antinucleoprotein antibodies was established by absorption tests in 31 sera and unmasked in three additional sera. The majority of patients demonstrated rheumatoid arthritis, but 2 patients had lupoid hepatitis. Differences in fluorescent patterns of staining and degrees of heterologous reactivity delineated two separate granulocyte‐specific antinuclear antibodies, one of which showed a significant association with granulocytopenia.
The stromal cell reaction of pigmented villonodular synovitis: An electron microscopic study
Authors: Wyllie John C. 
Published: February 2007

AbstractSynovium obtained from a patient with pigmented villonodular synovitis was studied with the electron microscope. Attention was directed to the stromal cell hyperplasia, a histological feature of this disease. It was shown that the participating cells were of two main types. The more abundant cell resembled the fibroblast of connective tissue in general, and appeared capable of collagen and mucopolysaccharide synthesis. The second cell type was similar to a macrophage and contained numerous hemosiderin inclusions.
Ultrastructural studies of the passage of gold thiomalate across the renal glomerular capillary wall
Authors: Strunk Stanley W. , Ziff Morris 
Published: February 2007

AbstractIn rats injected with gold thiomalate, electron‐dense deposits were observed in the lysosomes of glomerular epithelial cells indicating passage through the capillary wall. The formation of these deposits appeared to be dependent on the sulfur‐containing portion of the gold thiomalate molecule since similar, though not identical, deposits were seen in animals injected with sodium thiomalate. In 2 patients with gold nephrotoxicity, the kidney showed deposits in the peripheral capillary wall of the glomerulus resembling the deposits seen in immune‐complex disease and differing in appearance from the “gold inclusions” produced by gold thiomalate.
The significance of lysozyme (muramidase) in rheumatoid arthritis. i. levels in serum and synovial fluid
Authors: Pruzanski W. , Saito S. , Ogryzlo M. A. 
Published: February 2007

AbstractLysozyme (muramidase)* activity was estimated in 120 serum and 67 synovial fluid samples from patients with rheumatoid arthritis. These data were compared with the activity in samples from healthy controls and from patients with other forms of arthritis. In 35% of the serum samples and in 55% of the synovial fluid samples from patients with rheumatoid arthritis, lysozome activity was increased. Simultaneous estimations in serum and synovial fluid in 15 patients showed that lysozyme activity was significantly higher in synovial fluid than in serum. In serum from patients with other forms of arthritis, lysozyme activity was normal when renal function was normal. Low lysozyme levels were observed in synovial fluid obtained from patients with post‐traumatic arthritis, osteoarthritis, seronegative polyarthritis and arthritis associated with plasmacytic dyscrasias. However, high lysozyme levels were observed in acute gout, infectious arthritis and acute nonspecific synovitis. No direct correlation was found between the activity of lysozyme and the number of white blood cells in the synovial fluid. Attention is drawn here to the possible role of lysozyme as a contributor to intra‐articular inflammation.
DNA antibodies in childhood scleroderma
Authors: Hanson Virgil , Drexler Elizabeth , Kornreichxy Helen 
Published: February 2007

AbstractSeven of 18 children with focal scleroderma were found to have antibodies to DNA in the IgG or IgM fractions by immunofluorescent spot test, and 8 of the 18 had antibodies to HDNA in the same fractions. One of 6 children with progressive systemic sclerosis had antibody to HDNA in the IgG fraction. Four of 5 children with focal scleroderma were found to have precipitating antibody to DNA and HDNA on double diffusion in agarose. No antibodies to DNA or HDNA were demonstrated in 23 control children, nor in 24 children with dermatomyositis.
Transient osteoporosis of the hip, foot and knee
Authors: Swezey Robert L. 
Published: February 2007

AbstractA 54‐year‐old man with a migrating localized osteoporosis of a foot, hip, and knee over the course of two years is described. The differential diagnosis is considered in detail. Evidence of an intense uptake of 85Sr by the right femoral head suggested diffuse osteoblastic activity in the osteoporotic area. Eight reported cases, including the present case of recurrent osteolysis of the hip, knee, or foot, suggest that transient osteoporosis of the hip and migrating osteolysis of the lower extremity are variations of the same apparent neurovascular disorder.
Rheumatoid constrictive pericarditis, treated by pericardiectomy report of a case and review of the literature
Authors: Liss Joseph P. , Thompson Bachmann W. 
Published: February 2007

AbstractA case of constrictive cholesterol pericarditis with successful pericardiectomy in a patient with rheumatoid arthritis is presented. The relationship between rheumatoid arthritis and constrictive pericarditis is discussed. Twenty‐five cases of rheumatoid constrictive pericarditis, including 4 with constrictive cholesterol pericarditis undergoing pericardiectomy are reviewed. In these cases, steroid therapy did not appear to be beneficial, and early pericardiectomy is recommended.
The Complement System in Rheumatoid Synovitis. II. Intracytoplasmic Inclusions of Immunoglobulins and Complement
Authors: Britton Melvin C. , Schur Peter H. 
Published: February 2007

AbstractSynovial fluid leukocytes from patients with seropositive and seronegative rheumatoid arthritis and degenerative joint disease were examined by immunofluorescence for deposition of γG, γA, γM, γG1, γG2, γG3, γG4, C1q, C4, C3, rheumatoid factor, and albumin. The pattern of immunoglobulin and complement deposition, particularly in seropositive rheumatoid arthritis fluids with low complement levels, was consistent with activation of the complement system and phagocytosis of immune complexes.
Rheumatoid Synovial Cyst of the Hip. A Case Report
Authors: Samuelson Cecil , Ward John R. , Albo Dominic 
Published: February 2007

AbstractSynovial cysts are not uncommon in rheumatoid arthritis. These periarticular herniations of the synovialis are not difficult to diagnose in peripheral joints but have rarely been identified in the hips. A patient who presented with femoroinguinal swelling is presented. This swelling proved to be a synovial cyst originating from the hip joint. The diagnosis of synovial cyst should be considered whenever femoroinguinal swelling occurs in a patient with rheumatoid arthritis.
Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis. An electron microscopic study
Authors: Schumacher H. Ralph , Phelps Paulding 
Published: February 2007

AbstractMonosodium urate crystals added to human polymorphonuclear leukocytes are rapidly phagocytized. Crystals initially lie within phagosomes with a distinct, closely approximated phagosomal membrane. By 8 minutes phagolysosome distension is seen in some cells, degranulation begins, and phagolysosome membrane dissolution is seen. By 30 minutes there are many cell deaths with release of ingested crystals and cellular contents. Urate crystals have a profound and rapidly toxic effect on isolated leukocytes. The loss of phagolysosome membranes may be important in producing cell death.
The radiographic pattern of polyarthritis in Reiter's syndrome
Authors: Sholkoff Stephen D. , Glickman Morton G. , Steinbach Howard L. 
Published: February 2007

AbstractRoentgenographic and scintiphotographic studies of the arthritis of Reiter's syndrome demonstrate concurrent involvement of various small joints of the lower extremities often associated with sacroiliitis. The most frequently affected sites are the heels, toes, sacroiliac joints, and ankles and tarsals. Simultaneous involvement of these sites is characteristic of this syndrome.
A defect in the renal excretion of uric acid in Filipinos
Authors: Healey L. A. , Bayani‐Sioson Pelagia S. 
Published: February 2007

AbstractHyperuricemia is present in Filipinos living in the United States but is not found in Filipinos living in the Philippine Islands. This study investigates the role of the kidney in the development of Filipino hyperuricemia. An oral purine load was given to 13 Filipinos and 10 Caucasian subjects. All 10 of the Caucasians showed a marked increase, whereas 4 Filipinos had little or no increase in urinary uric acid. It had been postulated previously that some patients with gout are hyperuricemic because the kidneys retain uric acid. The Filipino subjects studied suggest that such a renal defect existed prior to the development of hyperuricemia or gout.
Direct lysis of lymphocytes by complement in patients with systemic lupus erythematosus
Authors: Stastny Peter , Ziff Morris 
Published: February 2007

AbstractLymphocytes from patients with active systemic lupus erythematosus (SLE) were found to undergo lysis when exposed to rabbit complement. A simple test procedure for quantitating this phenomenon was devised. In patients with active SLE and severe leukopenia, lymphocytes dropped to 29% after incubation with complement. The mean percent survival of lymphocytes from 15 patients with active SLE was 52 (21–78%). In 50 control subjects there was little or no decrease in the number of lymphocytes after exposure to complement. The results suggest that circulating lymphocytes of patients with active SLE may be coated with autoantibody rendering them susceptible to lysis upon addition of complement.
Reiter's disease, ankylosing spondylitis and rheumatoid arthritis occurring within a single family
Authors: Good Armin E. 
Published: February 2007

AbstractA family is reported in which three brothers had respectively, ankylosing spondylitis, Reiter's disease, and Reiter's disease followed by rheumatoid arthritis; the father had atypical spondylitis following stigmata of Reiter's disease. The literature of Reiter's disease affecting more than a single family member is reviewed.
Arthroplasty of the knee with tibial and/or femoral metallic implants in rheumatoid arthritis. Rheumatologic evaluation
Authors: Turner Robert A. , Brown Ernest M. , Sbarbaro John L. , Hollander Joseph L. 
Published: February 2007

AbstractFifty‐five patients with rheumatoid arthritis underwent 68 femoral mold and/or tibial plateau knee arthroplasties. The records of all patients were reviewed and 42 patients were examined and evaluated 1–6.5 years after surgery using a simple 100 point scoring system equally emphasizing pain, mobility, and functional capacity. Although 84.5% showed some improvement, mean overall change was modest at + 15.3 points. Forty‐seven complications occurred in 38 of the 68 operations. Implications for rheumatologists and referring physicians are discussed.