bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA’s adverse event reporting system database
Authors: Li Qun , Shan Wenya , Wu Saiwei 
Published: February 2025

BackgroundWith the improvement of living standards, an increasing number of patients are presenting with mixed hyperlipidemia. In addition to cholesterol reduction, it is imperative to lower triglyceride levels. The combination of statin and fibrate for reducing lipid levels has commonly been applied in clinical therapy. However, the combination of drugs also increases the risk of adverse events (AEs). In this study, we analyzed the safety signals of rosuvastatin-fenofibrate combination by assessing the publicly available US Food and Drug Administration Adverse Event Reporting System (FAERS), so as to provide a reference for rational clinical use of rosuvastatin and fenofibrate, and reduce the occurrence of related AEs.MethodsReports to the FAERS from 1 January 2004 to 19 March 2020 were analyzed. The proportional report ratio (PRR), reporting odds ratio (ROR), and Bayesian Confidence Propagation Neural Network (BCPNN) analysis were used to extract data from FAERS for suspected signals referring to the combination of rosuvastatin and fenofibrate.ResultsA total of 68 safety signals were detected from the top 250 AEs in 3,587 reports, of which 28 signals were not included in the drug labels. All the detected AEs were associated with 12 System Organ Classes (SOC), such as gastrointestinal, musculoskeletal and connective tissue, general diseases, investigations and nervous system. The most frequent AEs were analyzed, and it was found that women generally have a higher susceptibility to experiencing AEs, including pain, nausea, fatigue, myalgia, diarrhea, dyspnea, headache, weakness, and dizziness.ConclusionClinicians should pay more attention to the AEs of gastrointestinal and muscular system during combination therapy, and it is recommended to strengthen pharmaceutical care during clinical application.
Stability and changes in meaning in life profiles and their impact on mental health among chinese university students: a latent transition analysis
Authors: Kwok Sylvia Y. C. L. , Fang Siqi , Huang Bella Meici , Addis Tesfaw Alebel , Deng Xi 
Published: February 2025

BackgroundResearch on meaning in life (MIL) has predominately adopted variable-centered approaches. The few person-centered studies conducted were generally cross-sectional in nature and have failed to address changes in MIL. Furthermore, few studies have explored the stability of and changes in MIL on wellbeing.MethodsWe used latent transition analysis (LTA) to assess the MIL profiles of Chinese university students and to relate their experiences of meaning to their wellbeing. Meaning in Life Questionnaire, Brief Symptom Inventory, and the Mental Health Continuum Short Form were applied. In total, 317 students from five universities in Hong Kong participated in the survey at two time points 9 months apart.ResultsThe LTA identified three distinct profiles among the participants: meaning-oriented, bewildered, and indifferent. The LTA mover–stayer model revealed the relative stability of the students’ MIL profiles over 9 months. Specifically, the indifferent profile group was the most unstable, with a stability of 66.6%, suggesting that a significant portion of students in this group changed profiles. Conversely, the bewildered profile group had the greatest number of movers (64.8%), indicating a higher degree of flux within this group as well. Regarding the adaptive outcomes associated with each profile, results showed that students in the meaning-oriented profile group demonstrated the most adaptive outcomes, evidenced by the highest wellbeing scores and the lowest anxiety and depression scores among all the students.ConclusionThese findings provide insights into MIL profiles and how they change among Chinese university students. We also identified a relatively adaptive profile. Overall, these findings have practical implications and can contribute to advancing research on mental health and meaning.
Confronting the anxiety of Generation Z: electroacupuncture therapy regulates oxidative stress and microglia activity in amygdala-basolateral of socially isolated mice
Authors: Yin Tong , Yuan Junyun , Liu Lu , Wang Yinxin , Lin Yuanfang , Ming Kangwen , Lv Hang 
Published: February 2025

IntroductionAnxiety disorders are prevalent mental health conditions characterized by significant impairments in daily functioning and social interactions. Despite the effectiveness of pharmacological treatments, challenges such as medication resistance, adverse side effects, and the high rate of relapse necessitate the exploration of alternative therapies. Recently, electroacupuncture (EA) has garnered attention as a promising non-pharmacological intervention for anxiety disorders; however, the mechanisms by which EA exerts its anxiolytic effects remain poorly understood. This study aims to elucidate the role of microglial cells in anxiety, specifically examining how EA modulates microglial morphology and function within the basolateral amygdala (BLA) in the context of anxiety induced by social isolation.MethodsUtilizing a mouse model of social isolation-induced anxiety, we evaluated anxiety-like behaviors through the Elevated Plus Maze (EPM) and Open Field Test (OFT). Additionally, biochemical analyses and immunofluorescence imaging were performed to assess the expression of NADPH oxidase 2 (NOX2), microglial activation markers, and levels of oxidative stress.ResultsOur findings reveal that EA treatment significantly mitigates anxiety-like behaviors in mice, correlating with a reduction in NOX2 expression within BLA microglia and decreased levels of reactive oxygen species (ROS). Furthermore, EA was observed to restore normal microglial morphology, indicating its potential role in modulating microglial activity.DiscussionThe results of this study suggest that EA exerts its anxiolytic effects through the modulation of oxidative stress and the activity of microglia in the BLA. These findings provide new insights into the cellular mechanisms underlying the therapeutic effects of EA, highlighting the potential for non-pharmacological strategies in the management of anxiety disorders and paving the way for future research aimed at improving clinical outcomes for individuals suffering from anxiety.
The WRKY28-BRC1 Transcription Factor Module Controls Shoot Branching in Brassica napus
Authors: Zhang Ka , Zhang Jinfang , Cui Cheng , Chai Liang , Zheng Benchuan , Jiang Liangcai , Li Haojie 
Published: February 2025

The trade-off between growth and defense is common in plants. We previously demonstrated that BnaA03.WRKY28 weakened resistance strength but promoted shoot branching in Brassica napus (rapeseed). However, the molecular mechanism by which WRKY28 promotes branching formation is still obscure. In this study, we found that BnaA01.BRC1, BnaC01.BRC1, and BnaC03.BRC1 are mainly expressed in the leaf axils and contained W-box cis-acting elements in the promoter regions. BnaA03.WRKY28 directly bound to the promoter regions of these three copies and inhibited their expression. The brc1 mutants, the BnaA01.BRC1, BnaC01.BRC1 BnaA03.BRC1 and BnaC03.BRC1 were simultaneously knocked out, mediated by CRISPR/Cas9, and exhibited excessive branching. The expression level of the ABA biosynthesis encoding gene NCED3 was significantly reduced in the mutant compared to that in the WT. Instead, the expression level of the ABA catabolism encoding gene CYP707A3 was significantly higher than that in WT. These results suggest that the excessive branching of the brc1 mutant may be caused by the release of ABA-mediated bud dormancy. This study provides direct evidence for the potential mechanism of the WRKY28-BRC1 transcription factor module contributing to shoot branching in rapeseed.
Dissecção aórtica: uma revisão da epidemiologia, classificações, fatores de risco, sintomas, diagnóstico e tratamento
Authors: Cruz Jhonatas Emílio Ribeiro da , Cruz Maicon Felipe Ribeiro da , Pereira Matheus Martins , Silva João Victor Nunes 
Published: February 2025

Introdução: A dissecção aguda da aorta (DAA) é uma emergência médica rara, mas potencialmente fatal, com taxa de letalidade de 1 a 2% por hora após o início dos sintomas em pacientes não tratados. Portanto, seu diagnóstico rápido é vital para aumentar a chance de sobrevivência do paciente e prevenir complicações graves; Objetivo: esta revisão busca fornecer um resumo da epidemiologia da DAA, além disso, documentar informações sobre a classificações, fatores de risco, sintomas, diagnóstico e formas de tratamento atualizadas desta doença; Metodologia: Uma busca sistemática da literatura foi realizada usando os bancos de dados eletrônicos de 2013 até dezembro de 2023. Utilizou-se os operadores booleanos “and”, “or” ou/e “not” nas bases de acesso das plataformas PubMed, Scielo, Google Scholar, EBSCO e Bireme. Dos 37 títulos identificados pela busca, 20 estavam adequados de acordo com os critérios de inclusão e exclusão; Resultados: Os resultados demonstraram que sua incidência é de cerca de 2,6-3,6 casos por 100.000/ano. Dependendo do local da ruptura, a DAA é classificada como Stanford-A quando o trato torácico aórtico ascendente e/ou o arco estão envolvidos, e Stanford-B quando o alvo é a aorta torácica descendente e/ou o trato abdominal aórtico. Idade avançada, sexo masculino, história de hipertensão arterial e aneurisma de aorta conferem maior risco populacional atribuível. No entanto, pacientes com doenças genéticas do tecido conjuntivo, como síndrome de Marfan, Loeys Dietz, e pacientes com válvulas aórticas bicúspides apresentam risco aumentado de DAA em idades muito mais jovens. Os sintomas típicos da dissecção aórtica aguda incluem dor torácica súbita e intensa, hipotensão ou síncope e, portanto, simulam infarto agudo do miocárdio ou embolia pulmonar. A tomografia computadorizada com contraste (TC) é atualmente o estudo diagnóstico mais utilizado para detectar DAA e deve ser obtida em qualquer paciente com dor torácica e diagnóstico incerto. É altamente sensível e específico para dissecção. O tratamento da dissecção do tipo A envolve o rápido controle da pressão arterial, com agentes betabloqueadores intravenosos. A redução da pós-carga é obtida com nitroprussiato de sódio. Os pacientes com dissecção do tipo B são tratados com endopróteses. Esse procedimento tem sido associado a menor morbimortalidade operatória do que o reparo aberto; Conclusões: A DAA é uma emergência altamente fatal na qual a intervenção médica imediata é de suma importância. Em termos de tratamento, as tendências recentes mostram uma adoção crescente de abordagens endovasculares, que prometem melhorar os resultados dos pacientes.
Insulin-Like Growth Factor 2 Secreted from Mesenchymal Stem Cells with High Glutathione Levels Alleviates Osteoarthritis via Paracrine Rejuvenation of Senescent Chondrocytes
Authors: Cho Gun Hee , Bae Hyun Cheol , Lee Yu Jeong , Yang Ha Ru , Kang Hyewon , Park Hee Jung , Wang Sun Young , Kim You Jung , Kang Heun-Soo , Kim In Gyu , Choi Byung Sun , Han Hyuk-Soo 
Published: February 2025

Senescent chondrocytes, which are increased in osteoarthritic (OA) cartilage, promote cartilage defects and the senescent knee microenvironment by inducing senescence to surrounding normal chondrocytes by secreting senescence-associated secretory proteins. Many studies have used mesenchymal stem cells (MSCs) to treat OA, but MSC treatment remains challenging for clinical application owing to MSC quality control, engraftment, and fibrocartilage regeneration. Here, rather than relying on the direct regeneration of MSCs, we present a novel strategy to suppress OA by MSC-mediated senescent chondrocyte targeting via the paracrine activity of MSCs, thereby improving the knee microenvironment. First, to enable quality control of umbilical cord MSCs, priming MSCs by supplementing human platelet lysate (hPL) greatly enhanced MSC functions by increasing cellular glutathione levels throughout serial passaging. Intra-articular injection of primed MSCs successfully suppressed OA progression and senescent chondrocyte accumulation without direct regeneration. Indirect coculture with primed MSCs using transwell ameliorated the senescence phenotypes in OA chondrocytes, suggesting paracrine rejuvenation. Based on secretome analysis, we identified insulin-like growth factor 2 (IGF2) as a key component that induces paracrine rejuvenation by primed MSCs. The rejuvenation effects of IGF2 act through autophagy activation through the up-regulation of autophagy-related gene expression and autophagic flux. To cross-validate the effects of secreted IGF2 in vivo, knockdown of IGF2 in primed MSCs substantially abolished its therapeutic efficacy in a rabbit OA model. Collectively, these findings demonstrate that hPL supplementation enables MSC quality control by increasing MSC glutathione levels. The therapeutic mechanism of primed MSCs was secreted IGF2, which induces paracrine rejuvenation of senescent OA chondrocytes by activating autophagy.
PENGARUH MODEL PEMBELAJARAN GUIDED DISCOVERY LEARNING TERHADAP HASIL BELAJAR IPA SISWA KELAS V DI SDN 122340 PEMATANG SIANTAR
Authors: Sihombing Chintani , Sianturi Eduardo , Sipahutar Lamtumio , Nora Selvia , Tampubolon Joki 
Published: February 2025

Penelitian bertujuan untuk mengetahui apakah ada pengaruh model pembelajaran guided discovery learning terhadap hasil belajar IPA di kelas V. Jenis penelitian yang digunakan yaitu jenis penelitian kuantitatif quasi eksperimental dengan metode control-group Pre-tes Pos-tes. Populasi dalam penelitian ini yaitu seluruh siswa SD Negeri 122340 Pematangsiantar dan yang menjadi sampel dalam penelitian ini adalah seluruh siswa kelas VA dan VB SD Negeri 122340 Pematangsiantar, teknik smapel yang digunakan ialah simple sampling random dengan dua variabel yaitu : variabel bebas (X) yaitu model pembelajaran guided disovery learning dan variabel terikat (Y) yaitu hasil belajar IPA . Teknik pengumpulan data yang digunakan ialah berupa tes yang berlangsung pada tahun ajaran 2024/2025. Sebelum adanya perlakuan, soal terlebih dahulu soalnya di uji cobakan ke SD Negeri 122380 Jl. Kain Suji, setelah dilaksanakannya uji coba dapat diperoleh bahwa dari 30 soal yang diuji cobakan terdapat 6 soal yang tidak valid dan 24 soal valid. Hal ini soal yang valid akan digunakan pada saat penelitian di SD Negeri 122340 Pematangsiantar. Adapun uji analisis data yang digunakan yaitu Uji-T. Berdasarkan hasil penelitian maka diperoleh t hitung sebesar 11,123 dan t tabel di peroleh sebesar 0,3494, sehingga t hitung > t tabel, yang mana Ha diterima dan H0 di tolak. Hal ini menunjukkan bahwa terdapat pengaruh model pembelajaran guided discovery learning terhadap hasil belajar IPA siswa kelas V SD Negeri 122340 Pematangsiantar.

Keywords : Model Pembelajaran, Guided Discovery Learning, Hasil Belajar, IPA
Perspektif Hukum Pada Hak Pasien Atas Informasi Dalam Pelayanan Pembedahan
Authors: Parlin Julius , Buaton Tiarsen 
Published: February 2025

Tindakan pembedahan merupakan tindakan berisiko tinggi terhadap pasien yang dapat berakhir dengan kecacatan dan kematian, meski bertujuan untuk mencegah terjadinya komplikasi jika tidak dilakukan. Informasi medis yang termasuk didalammnya persetujuan tindakan pembedahan (informed consent) harus didapatkan pasien beserta keluarga oleh dokter terutama terkait dengan risiko dan komplikasi medis. Informasi medis harus tetap dijaga kerahasiaanya sebagai bentuk perlindungan hukum bagi pasien dan dokter. Penelitian yuridis normatif ini berfokus pada pengaturan hak pasien terhadap informasi dalam pelayanan pembedahan dan dampak bagi pelanggaran terhadap informasi layanan pembedahan oleh dokter dengan pendekatan perundang-undangan dan konsep serta dianalisis secara deskriptif dan preskriptif. Hasil dan pembahasan penelitian menunjukkan bahwa pengaturan hak pasien atas informasi pelayanan pembedahan telah dilindungi oleh Undang-undang RI Nomor 17 Tahun 2023 Tentang Kesehatan, Permenkes RI Nomor 36 Tahun 2012 tentang Rahasia Kedokteran, dan Permenkes Nomor 24 Tahun 2022 Tentang Rekam Medis; pelanggaran hukum terhadap hak pasien atas informasi pelayanan pembedahan oleh dokter telah diatur dalam kode etik profesi kedokteran, kitab undang-undang hukum perdata Pasal 1365, Kitab undang-undang Pidana Pasal 351, dan hukum administratif yang terkait dengan kerahasiaan informasi dan pelanggaran perikatan janji (verbintenis).
INCIDÊNCIA DOS ACIDENTES E COMPLICAÇÕES EM EXODONTIAS REALIZADAS POR ALUNOS DE GRADUAÇÃO
Authors: Araújo Arthur , Balan Santos Pereira Vinicius , Kaline Alves Araujo Cibely , Borba de Albuquerque Geovana , Maria Sarmento de Andrade Lima Fischer de Lyra Zélia , De Alencar Ramos Luciana , Barbosa Rodrigues dos Santos Rayssa , Lopes de Melo Débora , Julia Pimentel Fragoso Maria , Karina Marinho de Assis Dantas Luanna , Gabriele Alves de França Cailane , Júlia Andrade Patriota Vitória 
Published: February 2025

Trata-se de um estudo que aborda a incidencia de acidentes e complicações em exodontias, atribuída a técnicas anestésicas, utilização de instrumentais adequados e diagnósticos, bem como a utilização de técnicas cirúrgicas adequadas, mesmo reconhecendo que eventos imprevistos ainda ocorrem devido a fatores multifatoriais.O objetivo desse trabalho é avaliar a incidência de acidentes e complicações em exodontias realizadas por alunos da Faculdade de Odontologia do Recife, visando alertar sobre as principais ocorrências e melhorar a prática clínica.Trata-se de um estudo observacional, documental, prospectivo e transversal, realizado nas clínicas da faculdade. A amostra incluiu pacientes acima de 18 anos submetidos a exodontias e que concordaram em participar da pesquisa. Os dados foram coletados por meio de um questionário validado, com análise estatística realizada no software SPSS.Participaram 30 pacientes, com idade média de 47 anos. A maioria das exodontias foi de terceiros molares (26,7%) e a técnica anestésica mais utilizada foi o bloqueio regional + infiltrativa (60%). As complicações ocorreram em 5 pacientes, incluindo infecções e espiculas ósseas, enquanto nenhum acidente transoperatório significativo foi registrado.A incidência de acidentes e complicações em exodontias realizadas por alunos foi baixa, evidenciando que, com uma abordagem cuidadosa e técnica adequada, os resultados podem ser seguros e eficazes. O estudo reforça a importância da formação clínica para garantir procedimentos seguros e uma recuperação satisfatória para os pacientes.
How eccentricity modulates attention capture by direct face/gaze and sudden onset motion
Authors: Kürten Jens , Breil Christina , Pittig Roxana , Huestegge Lynn , Böckler Anne 
Published: February 2025

Abstract
We investigated how processing benefits for direct face/gaze and sudden onset motion depend on stimulus presentation location, specifically eccentricity from fixation. Participants responded to targets that were presented on one of four stimuli that displayed a direct or averted face and gaze either statically or suddenly. Between participants, stimuli were presented at different eccentricities relative to central fixation, spanning 3.3°, 4.3°, 5.5° or 6.5° of the visual field. Replicating previous studies, we found processing advantages for direct (vs. averted) face/gaze and motion onset (vs. static stimuli). Critically, while the motion-onset advantage increased with increasing distance to the center, the face/gaze direction advantage was not significantly modulated by target eccentricity. Results from a control experiment with eye tracking indicate that face/gaze direction could be accurately discriminated even at the largest eccentricity. These findings demonstrate a distinction between the processing of basic facial and gaze signals and exogenous motion cues, which may be based on functional differences between central and peripheral retinal regions. Moreover, the results highlight the importance of taking specific stimulus properties into account when studying perception and attention in the periphery.
Ряжский острог: эволюция понятий от крепости до застенка тюремной избы
Authors: Попова А.Д. , Ларин Н.В. 
Published: February 2025

В статье показана трансформация ряжского острога в тюремный застенок. Актуальность исследования заключается в более подробном изучении истории одного из древних городов центральной России, Ряжска, в контексте изменения функций оборонного механизма Московского государства. Выделяется несколько этапов эволюции острога: строительство как оборонительного сооружения в середине XVI века; трансформация в Ряжское городское поселение с социокультурным населением; потеря стратегического значения после расширения государственной границы и получение статуса провинции Переяславль-Рязанского наместничества; к середине XVII столетия — преобразование одной из внутренних острожных построек в тюремную избу с подчинением указанному наместничеству, а в XVIII веке — окончательное переустройство в тюрьму в связи с изменением геополитической позиции. В статье представлены эпизоды общероссийской практики, с которыми была связана деятельность ряжской тюрьмы, — содержание политических преступников и военнопленных. Исследование имеет широкую область применения: от краеведческих изысканий в архивных материалах до истории пенитенциарной системы в контексте изучения законодательных актов в связке с примерами из провинциальной местности.
The article shows the transformation of Ryazhsk Ostrog (fortress) into a penitentiary prison. The relevance of the study lies in a detailed study of the history of one of the ancient cities of central Russia, Ryazhsk, in the context of the changing functions of the defense mechanism of the Moscow State. Several periods of the Ostrog’s evolution are distinguished: its construction as a defensive structure in the middle of the XVI century; transformation into Ryazhsk urban settlement with its socio-cultural population; loss of strategic importance after the expansion of the state borders and obtaining the status of a province of Pereyaslavl-Ryazan vice-governorate; by the middle of the 17th century, transformation of one of the internal Ostrog buildings into a prison hut with subordination to the vice governor, and in the 18th century — the final reorganization into a prison due to changes in geopolitical and political situation in the region. The article presents episodes of national practice, with which the activities of the Ryazhsk prison were connected — the detention of political criminals and prisoners of war. The study has a broad scope: from local history research in archival materials to the history of the penitentiary system in the context of studying legislative acts in conjunction with examples from the region.