bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk management of green supply chains for agricultural products based on social network evaluation framework
Authors: Wang Wenke , Cao Qilin , Liu Yang , Zhou Cheng , Jiao Qinghui , Mangla Sachin Kumar 
Published: March 2024

AbstractThe green supply chain of agricultural products (GSCAP) is a key link for rural revitalization and sustainable development in China. However, it faces various risks from internal and external environments that threaten its performance and stability. This paper proposes a novel framework and system for identifying and evaluating the main risks in the GSCAP from the perspective of agricultural enterprises. The framework combines social network analysis (SNA) and an improved technique for order preference by similarity to an ideal solution (TOPSIS) method. SNA is used to analyze the correlations and influences among different types of risks, while the improved TOPSIS method is used to rank the risks of different GSCAPs and identify the key risks in each supply chain. The framework and system are verified by a case study of CDYBIT, a leading platform of food safety big data service in China. The results show that the supermarket supply chain has the highest risk, followed by the group catering supply chain, and the five‐star hotel supply chain has the lowest risk. The main risk factors for each supply chain are also discussed, and some suggestions for risk management are provided. This paper contributes to the literature by providing a comprehensive and systematic risk assessment framework and system for the GSCAP, which can help agricultural enterprises improve their risk awareness and response capabilities.
Cell fusion between tumor cells and macrophages promotes the metastasis of OSCC patient through the activation of the chemokine signaling pathway
Authors: Xia Chengwan , Zhang Qian , Pu Yumei , Hu Qingang , Wang Yuxin 
Published: March 2024

AbstractBackgroundTumor metastasis is responsible for the high mortality rate of patients with oral squamous cell carcinoma (OSCC). Although many hypotheses have been proposed to elucidate the mechanism of tumor metastasis, the origin of the metastatic tumor cells remains unclear. In this study, we explored the role of cell fusion in the formation of OSCC metastatic tumor cells.MethodsMurine OSCC tumor cells and macrophages were fused in vitro, and the cell proliferation, migration, and phagocytosis abilities of hybrid cells and parental cells were compared. Subsequently, we compared the transcriptome differences between hybrid and parental cells.ResultsMurine OSCC tumor cells and macrophages were successfully fused in vitro. The cytological and molecular experimental results revealed that OSCC tumor cells obtained a migration‐related phenotype after fusion with macrophages, and the migration ability of hybrid cells was related to the activation of the “chemokine signal pathway”.ConclusionAfter fusion with macrophages, the chemokine signaling pathway in OSCC tumor cells was activated, leading to metastasis.
Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis
Authors: Zi Mengli , Ma Yubo , Chen Jinxia , Pang Chuhong , Li Xiao , Yuan Li , Liu Zhuo , Yu Pengfei 
Published: March 2024

AbstractObjectiveThis study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g‐NENs).MethodsA retrospective enrollment of 142 patients diagnosed with g‐NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 and December 31, 2021. The study compared essential clinicopathological features and survival rates. Additionally, the prognosis of gastric neuroendocrine carcinomas/mixed neuroendocrine–non‐neuroendocrine neoplasms (g‐NEC/MiNEN) were contrasted with those of gastric adenocarcinoma (GAC) and signet ring cell carcinoma (SRCC).ResultsThe study comprised a total of 142 g‐NENs cases, with a male‐to‐female ratio of approximately 2:1. The 5‐year survival rates for g‐NEC and g‐MiNEN were 26.7% and 35.2%, respectively. Corresponding 5‐year survival rates for G1 and G2 were observed at 100% and 80.0%, respectively. g‐NEC/MiNEN showed a significantly worse prognosis compared to g‐NET (p < 0.001). g‐NEC/MiNEN exhibited a poor prognosis compared to GAC (p < 0.001), and within poorly differentiated GAC, g‐NEC/MiNEN demonstrated a worse prognosis (p = 0.007). Additionally, patients receiving postoperative adjuvant therapy exhibited notably prolonged overall survival (OS) in the case of g‐NEC/MiNEN (p = 0.010).ConclusionIn short, the prognosis of g‐NEC/MiNEN was worse than that of g‐NET, GAC and poorly differentiated GAC, but this group benefit from postoperative adjuvant therapy.
Do Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH
Authors: Guerrios‐Rivera Lourdes , Janes Jessica L. , De Hoedt Amanda M. , Klaassen Zachary , Terris Martha K. , Cooperberg Matthew R. , Amling Christopher L. , Kane Christopher J. , Aronson William J. , Fowke Jay H. , Freedland Stephen J. 
Published: March 2024

AbstractBackgroundWe previously reported that outcomes after radical prostatectomy (RP) were similar among non‐Hispanic Black, non‐Hispanic White, and Hispanic White Veterans Affairs (VA) patients. However, prostate cancer (PC) mortality in Puerto Rican Hispanics (PRH) may be higher than in other Hispanic groups. Data focused on PRH patients is sparse; thus, we tested the association between PR ethnicity and outcomes after RP.MethodsAnalysis included men in SEARCH cohort who underwent RP (1988–2020, n = 8311). PRH patients (n = 642) were treated at the PR VA, and outcomes were compared to patients treated in the Continental US regardless of race. Logistic regression was used to test the associations between PRH and PC aggressiveness, adjusting for demographic and clinicopathological features. Multivariable Cox models were used to investigate PRH versus Continental differences in biochemical recurrence (BCR), metastases, castration‐resistant PC (CRPC), and PC‐specific mortality (PCSM).ResultsCompared to Continental patients, PRH patients had lower adjusted odds of pathological grade group ≥2 (p < 0.001), lymph node metastasis (p < 0.001), and positive margins (p < 0.001). In contrast, PRH patients had higher odds of extracapsular extension (p < 0.001). In Cox models, PRH patients had a higher risk for BCR (HR = 1.27, p < 0.001), metastases (HR = 1.49, p = 0.014), CRPC (HR = 1.80, p = 0.001), and PCSM (HR = 1.74, p = 0.011). Further adjustment for extracapsular extension and other pathological variables strengthened these findings.ConclusionsIn an equal access setting, PRH RP patients generally had better pathological features, but despite this, they had significantly worse post‐treatment outcomes than men from the Continental US, regardless of race. The reasons for the poorer prognosis among PRH men require further research.
Impact of inflammation and the immune system on hepatocellular carcinoma recurrence after hepatectomy
Authors: She Sha , Shi Jinzhi , Zhu Jiling , Yang Fan , Yu Jia , Dai Kai 
Published: March 2024

AbstractHepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related death worldwide. Hepatectomy remains the first‐line treatment for patients with resectable HCC. However, the reported recurrence rate of HCC at 5 years after surgery is between 50% and 70%. Tumor‐related factors, including tumor size, number and differentiation, and underlying liver disease are well‐known risk factors for recurrence after treatment. In addition to tumor‐related factors, ever‐increasing amounts of studies are finding that the tumor microenvironment also plays an important role in the recurrence of HCC, including systemic inflammatory response and immune regulation. Based on this, some inflammatory and immune markers were used in predicting postoperative cancer recurrence. These include neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, cytotoxic T cells, and regulatory T cells, among others. In this review, we summarized the inflammatory and immune markers that affect recurrence after HCC resection in order to provide direction for adjuvant therapy after HCC resection and ultimately achieve the goal of reducing recurrence.
Early recurrence, time‐to‐recurrence, and recurrence patterns: Assessing their impact on survival outcomes in head and neck squamous cell carcinoma (R/M‐HNSCC) patients treated with first line platinum‐based chemotherapy
Authors: Pitakpaiboonkul Pasvich , Jiarpinitnun Chuleeporn , Pattaranutaporn Poompis , Ngamphaiboon Nuttapong 
Published: March 2024

AbstractBackgroundR/M‐HNSCC patients typically receive 1L platinum‐based chemotherapy with pembrolizumab or cetuximab. However, the outcomes for patients with early recurrence (<6 months) remain unclear due to their exclusion from most 1L studies. This study aimed to assess the impact of time‐to‐recurrence intervals (TTRI) and recurrence patterns on the survival of R/M‐HNSCC patients.MethodsWe identified non‐curable R/M‐HNSCC patients at our institution from 1/2008 through 6/2020. We analyzed the outcomes of early recurrent patients who received 1L systemic treatment, with different TTRIs and recurrence patterns.ResultsOur study included 234 eligible patients. The majority (47%) experienced early recurrence (<6 months), while 22%, 20%, and 11% had recurrences at 6–12 months, >12 months, and de novo metastasis, respectively. The platinum‐based regimen was the most commonly used chemotherapy (86%), with cetuximab and immunotherapy utilized in 3% and 5% of cases, respectively. Significant differences in PFS and OS were observed among TTRI groups. For patients with early recurrence, both platinum‐doublet and monotherapy treatments significantly improved OS. Locoregional recurrence (47%) was the most common, followed by distant metastasis (22%) and both (20%). Recurrence patterns were significantly associated with OS but not with PFS. In multivariate analysis, TTRI ≥12 months significantly correlated with improved PFS (HR 0.51; p = 0.004) and OS (HR 0.58; p = 0.009), whereas recurrent pattern did not.ConclusionTTRI significantly influenced the survival, while recurrence patterns did not. In our study, the retrospective design limited our ability to definitively establish whether early recurrent R/M‐HNSCC patients would benefit more from platinum‐doublet. Despite poor prognosis, early recurrent patients benefited from 1L systemic treatments. Given the variation in prognoses, TTRI should be considered a stratification factor in future clinical trials.
Eliminating Medicaid dental benefits and early‐stage oral cancer diagnoses
Authors: Semprini Jason , Reynolds Julie , Zahnd Whitney E. , Wehby George 
Published: March 2024

AbstractBackgroundDespite the importance of regular dental visits for detecting oral cancer, millions of low‐income adults lack access to dental services. In July 2009, California eliminated adult Medicaid dental benefits. We tested if this impacted oral cancer detection for Medicaid enrollees.MethodsWe analyzed Surveillance, Epidemiology, and End Results‐Medicaid data, which contains verified Medicaid enrollment status, to estimate a difference‐in‐differences model. Our design compares the change in early‐stage (Stages 0–II) diagnoses before and after dropping dental benefits in California with the change in early‐stage diagnoses among eight states that did not change Medicaid dental benefits. Patients were grouped by oropharyngeal cancer (OPC) and non‐OPC (oral cavity cancer), type, and the length of Medicaid enrollment. We also assessed if the effect of dropping dental benefits varied by the number of dentists per capita.ResultsDropping Medicaid dental benefits was associated with a 6.5%‐point decline in early‐stage diagnoses of non‐OPC (95% CI = −14.5, −3.2, p = 0.008). This represented a 20% relative reduction from baseline rates. The effect was highest among beneficiaries with 3 months of continuous Medicaid enrollment prior to diagnosis who resided in counties with more dentists per capita. Specifically, dropping dental coverage was associated with a 1.25%‐point decline in the probability of early‐stage non‐OPC diagnoses for every additional dentist per 5000 population (p = 0.006).ConclusionsEliminating Medicaid dental benefits negatively impacted early detection of cancers of the oral cavity. Continued volatility of Medicaid dental coverage and provider shortages may be further delaying oral cancer diagnoses. Alternative approaches are needed to prevent advanced stage OPC.
Impact of measurable residual disease in combination with CD19 on postremission therapy choices for adult t(8;21) acute myeloid leukemia in first complete remission
Authors: Jia Xi , Liao Naying , Yu Sijian , Li Huan , Liu Hui , Zhang Haiyan , Xu Jun , Yao Yunqian , He Han , Yu Guopan , Liu Qifa , Zhang Yu , Shi Pengcheng 
Published: March 2024

AbstractBackgroundThe post‐remission therapy (PRT) choices for adult t(8;21) acute myeloid leukemia (AML) in first complete remission (CR1) need to be further explored.AimsWe aimed to investigate the impact of measurable residual disease (MRD) combined with CD19 on PRT choices for adult t(8;21) AML in CR1.MethodsA total of 150 t(8;21) AML patients were enrolled, including 67 underwent chemotherapy (CMT) and 83 allogeneic hematopoietic stem cell transplantation (allo‐SCT) as PRT in CR1. Subgroup analyses were performed according to MRD level after three cycles of chemotherapy combined with CD19 expression.ResultsMultivariate analysis indicated MRDhigh after three courses of treatment (HR, 0.14 [95% CI, 0.03–0.66]; p = 0.013) and CD19 negativity (HR, 0.14 [95% CI, 0.02–0.96]; p = 0.045) were risk factors for relapse, while allo‐SCT was protective factor for relapse (HR, 0.34 [95% CI, 0.15–0.75]; p = 0.008). Grouped by MRD after three courses of chemotherapy, allo‐SCT had lower CIR (p < 0.001) and better OS (p = 0.003) than CMT for MRDhigh patients, CMT showed a higher CIR (35.99% vs. 15.34%, p = 0.100) but comparable OS (p = 0.588) than allo‐SCT for MRDlow patients. Grouped by CD19 expression, allo‐SCT demonstrated lower CIR (p < 0.001) and better OS (p = 0.002) than CMT for CD19− patients. CMT had a higher CIR (41.37% vs. 10.48%, p = 0.007) but comparable OS (p = 0.147) than allo‐SCT for CD19+ patients. Grouped by MRD combined with CD19, MRDhigh/CD19+ subsets were identified out of CD19+ patients benefiting from allo‐SCT with lower CIR (p = 0.002) and superior OS (p = 0.020) than CMT. CMT preserved comparable CIR (p = 0.939) and OS (p = 0.658) with allo‐SCT for MRDlow/CD19+ patients. MRDlow/CD19− subsets were also identified from MRDlow patients requiring allo‐SCT with lower CIR (p < 0.001) and superior OS (p = 0.008) than CMT. Allo‐SCT maintained lower CIR (p < 0.001) and superior OS (p = 0.008) than CMT for MRDhigh/CD19− patients.ConclusionsMRD combined with CD19 might optimize PRT choices for adult t(8;21) AML patients in CR1.
Sharing the neuroscience of living with housing instability: Collaborating with front‐line workers to co‐create a knowledge translation activity
Authors: Draper Ethan C. , Burgess Heather J. , Chisholm Cheryl , Barker Conor , Mazerolle Erin L. 
Published: March 2024

AbstractTraumatic brain injuries, mental illnesses and neurodevelopmental disorders are established risk factors for housing instability. Further, these brain‐associated conditions may result in additional barriers to accessing services. We explored perspectives of front‐line housing support workers concerning the neuroscience of housing instability to co‐create a knowledge translation (KT) activity. Interviews were conducted with front‐line workers (participant‐researchers) about the impacts of brain‐associated conditions in individuals experiencing housing instability. We combined interview results with existing neuroscience research to develop a KT activity. We collaboratively planned improvements to the KT activity via a focus group. The participant‐researchers found statistics about the overrepresentation of brain‐associated conditions among individuals experiencing housing instability compelling. They expressed that the greatest impact may arise if we target politician and policymaker audiences. Improved awareness of the neuroscience of housing instability may provide motivation for addressing systemic factors that perpetuate the violence of living unhoused.
The role and molecular mechanism of NOP16 in the pathogenesis of nasopharyngeal carcinoma
Authors: Xiong Wenmin , Li Daojing , Ao Fenghua , Tu Ziwei , Xiong Jianping 
Published: March 2024

AbstractWe aimed to explore the effects of NOP16 on the pathogenesis of nasopharyngeal carcinoma (NPC) and the related mechanism. In this study, the expression level of NOP16 in NPC tissues and adjacent tissues was measured by qRT‐polymerase chain reaction (PCR) and immunohistochemistry (IHC) tests. In the in vitro study, the expression levels of NOP16 and RhoA/phosphatidylinositol 3‐kinase (PI3K)/Akt/c‐Myc and IKK/IKB/NF‐κB signalling pathway‐related proteins in NPC cells were measured by qRT‐PCR and Western blot (WB). CCK8 assays and colony formation assays were used to detect cell proliferation. Transwell assays were used to detect the migration and invasion ability of NPC cells. Flow cytometry and WB were used to measure the level of apoptosis. For the in vivo study, NPC xenograft models were established in nude mice, and tumour weight and volume were recorded. The expression levels of NOP16 and RhoA/PI3K/Akt/c‐Myc signalling pathway‐related proteins and mRNAs were measured by immunofluorescence, qRT‐PCR and WB experiments. In clinical samples, the results of qRT‐PCR and IHC experiments showed that the expression level of NOP16 was significantly increased in NPC tissues. In the in vitro study, the results of qRT‐PCR and WB experiments showed that NOP16 was significantly increased in NPC cells. The CCK8 assay, colony formation assay, transwell assay and flow cytometry results showed that knocking out NOP16 inhibited the proliferation, migration and invasion of NPC cells and increased apoptosis. WB results showed that knocking out NOP16 inhibited the RhoA/PI3K/Akt/c‐Myc and IKK/IKB/NF‐κB signalling pathways. These effects were reversed by 740Y‐P (PI3K activator). In the in vivo study, knockdown of NOP16 reduced tumour volume and weight and inhibited the RhoA/PI3K/Akt/c‐Myc signalling pathway. In conclusion, knockdown of NOP16 inhibited the proliferation, migration and invasion of NPC cells and induced apoptosis by inhibiting the RhoA/PI3K/Akt/c‐Myc and IKK/IKB/NF‐κB pathways, leading to the malignant phenotype of NPC.
Biophysical Investigation of RNA ⋅ DNA : DNA Triple Helix and RNA : DNA Heteroduplex Formation by the lncRNAs MEG3 and Fendrr
Authors: Krause Nina M. , Bains Jasleen K. , Blechar Julius , Richter Christian , Bessi Irene , Grote Phillip , Leisegang Matthias S. , Brandes Ralf P. , Schwalbe Harald 
Published: March 2024

AbstractLong non‐coding RNAs (lncRNAs) are important regulators of gene expression and can associate with DNA as RNA : DNA heteroduplexes or RNA ⋅ DNA : DNA triple helix structures. Here, we review in vitro biochemical and biophysical experiments including electromobility shift assays (EMSA), circular dichroism (CD) spectroscopy, thermal melting analysis, microscale thermophoresis (MST), single‐molecule Förster resonance energy transfer (smFRET) and nuclear magnetic resonance (NMR) spectroscopy to investigate RNA ⋅ DNA : DNA triple helix and RNA : DNA heteroduplex formation. We present the investigations of the antiparallel triplex‐forming lncRNA MEG3 targeting the gene TGFB2 and the parallel triplex‐forming lncRNA Fendrr with its target gene Emp2. The thermodynamic properties of these oligonucleotides lead to concentration‐dependent heterogeneous mixtures, where a DNA duplex, an RNA : DNA heteroduplex and an RNA ⋅ DNA : DNA triplex coexist and their relative populations are modulated in a temperature‐dependent manner. The in vitro data provide a reliable readout of triplex structures, as RNA ⋅ DNA : DNA triplexes show distinct features compared to DNA duplexes and RNA : DNA heteroduplexes. Our experimental results can be used to validate computationally predicted triple helix formation between novel disease‐relevant lncRNAs and their DNA target genes.
Examining online education at tribal community colleges
Authors: Allchin Hope , Fernandez Frank 
Published: March 2024

AbstractFor students at tribal colleges, online courses provide access to college coursework, particularly for non‐traditional students and students who live in rural communities. In addition, online courses provide unique opportunities for Indigenous students to connect with their tribal communities and to participate in cultural revitalization and language acquisition efforts being led by tribal colleges, regardless of their proximity to a tribal college. This article analyzes descriptive data of two‐year tribal colleges that provide a snapshot of their presence and spending to support online education. We offer policy recommendations to support greater online education opportunities for Indigenous students and to expand Indigenous cultural revitalization and language acquisition through online courses.
Challenging in pulmonary thromboembolism diagnosis in patients with disproportionate pulmonary hypertension and severe mitral stenosis: Report of two cases
Authors: Khezerlouy‐Aghdam Naser , Toufan Tabrizi Mehrnoush , Seyed Toutounchi Kia , Jabbaripour Sarmadian Amirreza , Masoumi Shahab 
Published: March 2024

Key Clinical MessageBefore valvular interventions, echocardiography, especially the TEE or the ventilation/perfusion scan, should be performed to detect silent PTE and set a more accurate treatment and surgical plan.AbstractPulmonary hypertension (PH) is a progressive and critical disease that can be caused by mitral stenosis (MS). Some of these patients present with disproportionate PH, which is an uncommon phenomenon and is considered a challenging diagnostic and treatment process. In these patients, other causes may also play a role in developing PH. This report presented two cases with disproportionate PH and severe MS who were scheduled for percutaneous mitral valvuloplasty (PMV). The pre‐procedural echocardiography revealed systolic pulmonary artery pressure (sPAP) of 90 and 120 mmHg, mitral valve area of 0.80 and 0.55 cm2 by three‐dimensional (3D) planimetry, and diastolic pressure gradient (DPG) of 13 and 18.8 mmHg, respectively. Furthermore, in the first patient, 3D transesophageal echocardiography (TEE) revealed multiple saddle‐type organized thrombi in the proximal parts of the right and left pulmonary arteries, extending to the distal branches. In the second patient, 3D TEE revealed a large, relatively fresh, flow‐limiting thrombosis in the proximal part of the right pulmonary artery. The diagnosis of pulmonary thromboembolism (PTE) in both patients was confirmed by CT angiography. In both patients, the valves were surgically repaired, while all thrombi were removed from the cardiac chambers and pulmonary vessels during surgery. In addition, patients underwent warfarin therapy orally. They were followed up 6 months after the intervention, and their clinical symptoms had improved significantly.