bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional
Dyspepsia through the CRF Signaling Pathway
Authors: Liu Tong , Wang Haili , Liu Jiayi , Tan Ruirui , Chen Lili , Liang Xurong , Li Ailin , Qi Chenxi , Wang Zhaohui 
Published: April 2024

Background:
In the domain of functional gastrointestinal disorders, Functional Dyspepsia
(FD) stands out due to its widespread occurrence internationally. Historically, electroacupuncture
(EA) has been employed as a therapeutic modality for FD, demonstrating notable
clinical efficacy.

Objectives:
This research aimed to delve into the impact of EA on stress responses, minor duodenal
inflammatory processes, and the integrity of the intestinal barrier within FD-affected rodent
models while also elucidating the underlying mechanisms.

Methods:
Thirty-six male Wistar rats were evenly distributed into three cohorts: a normal, a
modeled FD, and an EA treatment group. The FD condition in the rats, barring those in the
normal, was induced through a series of multifactorial procedures. For the EA cohort, the rats
received electroacupuncture at the acupoints RN12 (Zhongwan) and ST36 (Zusanli) for 20
minutes daily over a span of one week. The gastric residue rate (GRR), intestinal propulsion rate
(IPR), and changes in emotional state were measured in each group of rats. Additionally, serum
levels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and
corticosterone (CORT) were detected, and the duodenal inflammatory condition and intestinal
mucosal barrier status were observed through staining and fluorescence. The expression levels
of Claudin-1, Junctional Adhesion Molecule 1 (JAM-1), Corticotropin-Releasing Factor (CRF),
and Corticotropin-Releasing Factor Receptor 1 (CRF-R1) were also detected.

Results:
The study demonstrated that EA had a positive effect on body weight and food intake,
GRR, and IPR in FD rats. Additionally, the EA group showed a decrease in serum levels of
CRH, ACTH, and CORT, as well as a decrease in the number of duodenal mast cells and tryptase
content. Furthermore, the expression of tight junction proteins Claudin-1 and JAM-1 was
increased in the EA group compared to the model group. EA also reduced the levels of CRF and
CRF-R1 in the hypothalamus and duodenum.

Conclusion:
EA has been shown to improve the stress state of FD rats, inhibit the activation of
mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal
mucosal barrier. It is believed that EA achieves these effects by modulating the expression
of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling
pathway. This provides a new approach to treating FD.
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of
Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis
Authors: Zhang Ziyan , Wang Zhuowei , Fan Hong , Li Jiayi , Ding Jiaqi , Zhou Gang , Yuan Chengfu 
Published: April 2024

Abstract:
Fucosylation is facilitated by converting GDP-mannose to GDP-4-keto-6-deoxymannose,
which GDP-mannose 4,6-dehydratase, a crucial enzyme in the route, carries out. One of the most
prevalent glycosylation alterations linked to cancer has reportedly been identified as fucosylation.
There is mounting evidence that GMDS is intimately linked to the onset and spread of cancer. Furthermore,
the significance of long-chain non-coding RNAs in the development and metastasis of
cancer is becoming more well-recognized, and the regulatory mechanism of lncRNAs has emerged
as a prominent area of study in the biological sciences. GMDS-AS1, an antisense RNA of GMDS,
was discovered to have the potential to be an oncogene. We have acquired and analyzed relevant
data to understand better how GMDS-AS1 and its lncRNA work physiologically and in tumorigenesis
and progression. Additionally, we have looked into the possible effects of these molecules on
cancer treatment approaches and patient outcomes.
The physiological roles and putative processes of GMDS and lncRNA GMDS-AS1 throughout the
development and progression of tumors have been assembled and examined. We also examined how
these chemicals might affect patient prognosis and cancer therapy approaches.
GMDS and GMDS-AS1 were determined to be research subjects by searching and gathering pertinent
studies using the PubMed system. The analysis of these research articles demonstrated the
close relationship between GMDS and GMDS-AS1 and tumorigenesis and the factors that influence
them.
GMDS plays a vital role in regulating fucosylation. The related antisense gene GMDS-AS1 affects
the biological behaviors of cancer cells through multiple pathways, including the key processes of
proliferation, migration, invasion, and apoptosis, providing potential biomarkers and therapeutic
targets for cancer treatment and prognosis assessment.
Factors That Influence Successful Adoption of Real-Time Location Systems for Use in a Dementia Care Setting: Mixed Methods Study
Authors: Haslam-Larmer Lynn , Grigorovich Alisa , Shum Leia , Bianchi Andria , Newman Kristine , Iaboni Andrea , McMurray Josephine 
Published: April 2024

Background
Technology has been identified as a potential solution to alleviate resource gaps and augment care delivery in dementia care settings such as hospitals, long-term care, and retirement homes. There has been an increasing interest in using real-time location systems (RTLS) across health care settings for older adults with dementia, specifically related to the ability to track a person’s movement and location.

Objective
In this study, we aimed to explore the factors that influence the adoption or nonadoption of an RTLS during its implementation in a specialized inpatient dementia unit in a tertiary care rehabilitation hospital.

Methods
The study included data from a brief quantitative survey and interviews from a convenience sample of frontline participants. Our deductive analysis of the interview used the 3 categories of the Fit Between Individuals, Task, and Technology framework as follows: individual and task, individual and technology, and task and technology. The purpose of using this framework was to assess the quality of the fit between technology attributes and an individual’s self-reported intentions to adopt RTLS technology.

Results
A total of 20 health care providers (HCPs) completed the survey, of which 16 (80%) participated in interviews. Coding and subsequent analysis identified 2 conceptual subthemes in the individual-task fit category, including the identification of the task and the perception that participants were missing at-risk patient events. The task-technology fit category consisted of 3 subthemes, including reorganization of the task, personal control in relation to the task, and efficiency or resource allocation. A total of 4 subthemes were identified in the individual-technology fit category, including privacy and personal agency, trust in the technology, user interfaces, and perceptions of increased safety.

Conclusions
By the end of the study, most of the unit’s HCPs were using the tablet app based on their perception of its usefulness, its alignment with their comfort level with technology, and its ability to help them perform job responsibilities. HCPs perceived that they were able to reduce patient search time dramatically, yet any improvements in care were noted to be implied, as this was not measured. There was limited anecdotal evidence of reduced patient risk or adverse events, but greater reported peace of mind for HCPs overseeing patients’ activity levels.
Pavlo Boichenko: a life given to people
Authors: Chaban M.P. , Shevtsova Z.I. , Gaponov V.V. 
Published: April 2024

The article represents a life and a professional path of zemstvo doctor Pavlo Nikiforovich Boichenko. His contribution to the development of medical services in the Dnipro region has been presented. The doctor participated in the provision of medical aid to the wounded people during the Crimean War (1853–1856), and assisted in the elimination of the cholera epidemic. The ascetic created the description of Church institutions in Katerynoslav, took care of orphanages. Pavlo Boichenko received awards and gratitude from the authorities, zemstvo, and fellow citizens. The provided material will contribute to the popularization of the figure of the Ukrainian zemstvo doctor.
Cultivation of Business Ethic Consciousness in Business English Teaching of Chinese Higher Education
Authors: Lu Yuting 
Published: April 2024

Business English teaching of higher education in China has made great strides in recent years so that students’ Business English skills have been significantly improved. However, the need for ethic consciousness in Business English teaching has become increasingly apparent. This article aims to analyze and respond to the deficiency of ethic consciousness in Business English teaching, and seeks to feasible solutions for teaching reform to meet the needs of development of higher education in China.
EMBEDDING WORK-INTEGRATED LEARNING AT UNDERGRADUATE COLLEGE-LEVEL CURRICULUM TO ENHANCE EMPLOYABILITY SKILLS AMONG STUDENTS
Authors: Srivastava Reema , Haghi Maryam 
Published: April 2024

Work-integrated learning (WIL) is a prominent, flourishing, educational phenomenon which has brought about numerous positive changes in the field of higher education globally. The corporate sector and the governments in the world are seeking ‘work-ready’ graduates. WIL as an umbrella term includes a variety of strategies and approaches that incorporate theory with practice of work within a purposefully designed curriculum. WIL makes meaningful, relevant connections to work throughout the curriculum in higher educational contexts which is intricately interwoven with employability skills and enhances these skill sets. Some of the pedagogical approaches adopted in WIL are Practice-based learning, Professional practices, Problem-based-learning, Experiential learning, Workplace learning, and Practice-based education. A study adopting an exploratory mixed-method was conducted in Middle East College, Oman including in-depth survey and interviews with faculty members, graduates, alumnus and students at undergraduate level to determine the efficacy of the contents of the curriculum enhancing Employability Skills of the students. Findings indicate that the curriculum enriched with WIL develops (a) General employability skills and respective requirements of a workplace, (b) Effective communication with colleagues across diverse roles, (c) Attitudes toward working effectively and competently, (d) Enhance academic knowledge and develop transferable skills, (e) Develop an understanding of ethical practices, (f) Build a professional identity and (g) Increase digital literacy skills. Students’ WIL experiences were taken into account in designing and implementing curricula related to WIL which are in line with enhancement of employability among students. The results of this research are valuable for practitioners in higher level educational contexts to integrate WIL and employability skills to contribute to global enhancement of these two flourishing phenomena.
A Statistical Review of the Impact of COVID-19 on the World
Authors: Zaidi Zeenat 
Published: April 2024

The COVID-19 epidemic has caused an unparalleled era of disruption, significantly impacting public health, the environment, the economy, and civilizations globally. This data analysis offers a thorough examination of COVID-19's worldwide effects. Through statistical methods, it explores the epidemic's spread, mechanics of transmission, and social repercussions. In addition, it carries out quantitative research to comprehend how the pandemic affects society's behavior, healthcare systems, and the environment. To understand the substantial repercussions of the pandemic, the review combines many datasets and presents data from a reliable source. Through the analysis of both quantitative and qualitative data, this review focuses on the pandemic's effects from several perspectives, such as public health measurements, societal shifts, and environmental changes. The findings demonstrate the horrifying cost of human deaths and describe how society has adapted to new issues and routines. The study additionally examines the data's graphical and tabular format, which comprises the total number of COVID-19 cases and fatalities that have been confirmed in nine different nations.
Timing of Moderate to Vigorous Physical Activity, Mortality, Cardiovascular Disease, and Microvascular Disease in Adults With Obesity
Authors: Sabag Angelo , Ahmadi Matthew N. , Francois Monique E. , Postnova Svetlana , Cistulli Peter A. , Fontana Luigi , Stamatakis Emmanuel 
Published: April 2024

OBJECTIVE
To assess the association between timing of aerobic moderate to vigorous physical activity (MVPA) and risk of cardiovascular disease (CVD), microvascular disease (MVD), and all-cause mortality in adults with obesity and a subset with obesity and type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
Participants included adults with obesity (BMI ≥30 kg/m2) and a subset of those with T2D from the UK Biobank accelerometry substudy. Aerobic MVPA was defined as bouts of MVPA lasting ≥3 continuous minutes. Participants were categorized into morning, afternoon, or evening MVPA based on when they undertook the majority of their aerobic MVPA. The reference group included participants with an average of less than one aerobic MVPA bout per day. Analyses were adjusted for established and potential confounders.

RESULTS
The core sample included 29,836 adults with obesity, with a mean age of 62.2 (SD 7.7) years. Over a mean follow-up period of 7.9 (SD 0.8) years, 1,425 deaths, 3,980 CVD events, and 2,162 MVD events occurred. Compared with activity in the reference group, evening MVPA was associated with the lowest risk of mortality (hazard ratio [HR] 0.39; 95% CI 0.27, 0.55), whereas afternoon (HR 0.60; 95% CI 0.51, 0.71) and morning MVPA (HR 0.67; 95% CI 0.56, 0.79) demonstrated significant but weaker associations. Similar patterns were observed for CVD and MVD incidence, with evening MVPA associated with the lowest risk of CVD (HR 0.64; 95% CI 0.54, 0.75) and MVD (HR 0.76; 95% CI 0.63, 0.92). Findings were similar in the T2D subset (n = 2,995).

CONCLUSIONS
Aerobic MVPA bouts undertaken in the evening were associated with the lowest risk of mortality, CVD, and MVD. Timing of physical activity may play a role in the future of obesity and T2D management.
PENGGUNAAN MEDIA FLASH CARD DALAM EKSTRAKURIKULER SENI TARI PADA SISWA TUNAGRAHITA DI SEKOLAH LUAR BIASA YPPLB KOTA PADANG
Authors: Sari Novi Kurnia , Asriati Afifah 
Published: April 2024

Tujuan Penelitian ini adalah untuk mengetahui seberapa besar pengaruh penggunaan media FlashCard terhadap daya ingat siswa kelas IX smp SLB YPPLB Kota Padang. Jenis penelitian ini adalah penelitian Kuantitatif. Variabel dalam penelitian ini adalah Variabel bebas (IndependentVariable) dan Variabel Terikat (Dependent Variable). Instrumen penelitian ini menggunakan tes hafalan gerak tari. Langkah-langkah untuk menganalisis data adalah Uji Normalitas, Uji Paired Sample t-Test, Uji Homogenitas dan Uji Independent Sample t-Test. Hasil Penelitian menunjukkan bahwa terdapat perbedaan hasil dari kegiatan ekstrakurikuler tari siswa antara penggunaan media Berbasis Manusia (Konvensional) dengan media FlashCard. Hal ini terlihat dari nilai rata-rata hasil kemampuan daya ingat siswa kelas eksperimen yaitu 88,33, sedangkan nilai rata-rata hasil kemampuan daya ingat siswa kelas kontrol yaitu 73,33. Kemudian diperkuat lagi dengan hasil pengujian Independent Sample t-Test dimana nilai Sig. (2-tailed) sebesar 0,003 0,05. Dengan demikian dapat disimpulkan bahwa Hipotesa Ho ditolak dan Ha diterima, yang artinya ada pengaruh yang signifikan antara kelompok yang diberikan media FlashCard dengan yang hanya menggunakan media berbasis Manusia (Konvensional).
Vybrané aspekty zrušení a vypořádání obecného podílového spoluvlastnictví se zaměřením na solventnost spoluvlastníků
Authors:   University of West Bohemia, Chupáč Miroslav 
Published: April 2024

This contribution deals with the theme of ‘sovereignty’, especially state sovereignty, as a problematic concept that, from legal modernity onwards, falls into crisis and determines multiple aporias. According to the theoretical constructions of the two authors here considered in a diachronic key, Kelsen and Ferrajoli, it should be overcome in favour of an internationalist dimension of law, which can effectively guarantee the protection of fundamental rights and peace, thus approaching the horizon that Kant outlined at the end of the 18th century. This contribution will therefore set out several reasons why such a shift is desirable.
Zákonná formulace zásady rychlosti trestního řízení z pohledu samostatné existence této zásady
Authors:   Právnická fakulta Univerzity Karlovy, Kobyljanský Adam 
Published: April 2024

The state tries to increase the speed of criminal proceedings in many ways. One of them is the regulation of criminal procedural law. Above the particular procedural provisions related to the speed of proceedings, the Code of Criminal Procedure contains a general formulation of the principle of the speedy criminal proceedings. This paper analyses it and attempts to answer the question of whether the Code of Criminal Procedure regulates the requirement of speed as a independent fundamental principle of criminal procedure, and what the implications of this statutory conception are for the principle‘s existence. It can be summarised that the Code of Criminal Procedure does not regulate the requirement of speed as a independent fundamental principle, but rather as part of the the principle of ex officio proceedings, or at least in close connection with it. However, this conception is based on the theoretical interconnection of the principles mentioned and cannot be taken to imply that the principle of speed is not independent. At present, the formulation chosen in this way does not seem appropriate for several reasons and it would be more suitable to regulate the principle of speed in a separate provision of the Code of Criminal Procedure. The good news is that this is precisely how the new draft of the code currently conceives it, although even this draft is not ideal.
Nesezdané soužití v České republice
Authors:   University of West Bohemia, Kotroušová Denisa 
Published: April 2024

Cohabitation is a very common way of common living these days, including the Czech Republic. Almost half of the children born alive are born outside of marriage these days. The aim of this contribution is therefore to examine whether or not the Czech law reacts to this social reality and if and how it regulates the legal position and rights and duties of the cohabitants. The primary attention is being put on the Civil Code and its regulation. As the contribution unfolds, the Civil Code is aware of the existence of cohabitation and offers two terms to describe cohabitants – the close person, and the persons living in the same household. Is such regulation and rights and duties assigned to those subjects sufficient, though? Is the regulation limited only to the Civil Code, or can we find it elsewhere? These are just some of the questions posed in the contribution. Except for the examination of the Czech regulation of cohabitation, the current European trends are taken into consideration as well.
Postavení správce závodu
Authors:   University of West Bohemia, Koutenský Otakar 
Published: April 2024

The article deals with a general outline of the position of the warden of enterprise during the execution by sale of the enterprise. The article discusses in detail who and how the warden of enterprise can be appointed, as well as the rights and obligations of the warden of enterprise in the management of the enterprise, including the claims of the warden of enterprise for payment of remuneration and reimbursement of finished expenses.
Rule of law, democracy and human rights in the light of Advisory Opinion OC-28/21 of the Inter-American Court of Human Rights
Authors:   Faculty of Law and Administration, Department of Public International Law, Maria Curie-Skłodowska University of Lublin, Lis Edyta 
Published: April 2024

One of the characteristics of the Latin American systemic landscape is the widespread presidentialism. The position of the executive is very strong, with certain law-making powers. Most constitutions of member states of OAS provide for a fixed term of presidential re-election but few of them provide for reelections without a defined limit. Each of these solutions has its own pros and cons. However, the indefinite presidential reelection raises considerable doubts. It may pose a threat to the proper functioning of the state, dismantling democratic oversight, undermine effective exercise of political rights, weaken the institutions and mechanism indispensable for protecting individuals and is contrary to the principle of representative democracy. Human rights, democracy, rule of law go hand in hand and lie at the heart of the Inter-American Court of Human Rights case law. This inextricable link was once again stressed by the IACHR in its advisory opinion on the indefinite presidential reelection in presidential systems in the context of the inter-American system of human rights. The opinion proves that the Court, through its jurisprudence, contributes to enhancement and promotion of the rule of law and the principle of democracy in Latin America.
Plnění splátkového kalendáře prostřednictvím smlouvy o důchodu
Authors:   University of West Bohemia, Mifek Jan 
Published: April 2024

The contribution discusses the fulfillment of the repayment schedule of the debtor in insolvency proceedings from funds obtained on the basis of a negotiated pension contract. The analysis is devoted to the institution of the pension contract, the fulfillment of the repayment schedule in insolvency proceedings with an emphasis on the provided pension contract, the dishonest intention of the debtor when negotiating such contracts and the person of the pension payer. The view of the jurisprudence of higher courts on individual aspects of such contracts is taken into account.
Náhrada újmy v pracovněprávních vztazích
Authors:   University of West Bohemia, Papež Petr 
Published: April 2024

Liability for damages is a special form of relationship where, on the basis of a violation of an already existing primary obligation, a secondary obligation – the obligation to compensate the damages – arises for the harming party. There is a considerable number of „types“ of liability for damages, many of which are primarily governed by the Civil Code, others are governed by special statutes. Compensation for damages in employment relations is regulated in a special legal regulation – Act No. 262/2006 Coll., Labor Code, as amended, which covers the legal regulation in question rather comprehensively and devotes its entire eleventh part to it. The legislation in question reflects the unequal status of the subjects of labor relations, especially the protection of the employee. The aim of this article is the compensation for damages in employment relations de lege lata, especially the liability of the employer for damages.