bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain attitudes and pain outcomes among people with bleeding disorders: Results from community voices in research
Authors: Pierce Corey , Branscum Adam , Irvin Veronica L. , Elander James , Bovbjerg Marit , Witkop Michelle , Smit Ellen 
Published: February 2024

AbstractIntroductionAmong people with bleeding disorders (PwBD), pain is a major problem and pain treatments are often ineffective. Understanding of psychological factors involved in pain processing is limited. Maladaptive pain attitudes are associated with worse pain outcomes and adaptive pain attitudes are associated with better outcomes in high pain conditions, but relationships between pain attitudes and pain outcomes are so far unexplored among PwBD.AimTo investigate relationships between pain attitudes and pain outcomes among PwBD.MethodsPain attitudes were measured with the Survey of Pain Attitudes, containing two adaptive scales (Control and Emotion) and five maladaptive scales (Disability, Harm, Medication, Solicitude, Medical Cure). Adults with bleeding disorders, who had pain, and were enrolled in Community Voices in Research were eligible. Participants (n = 72) completed an online survey. Cross sectional associations between pain attitudes and pain outcomes (pain and prescribed pain medication use) were investigated using logistic regression.ResultsAfter adjustment for covariates, greater Control attitudes were associated with lower odds of more severe pain, and greater Disability, Harm, and Medication attitudes were all associated with higher odds of more severe pain and with higher odds of any prescribed pain medication use and opioid pain medication use.ConclusionsWe presented compelling evidence of relationships between pain attitudes and pain outcomes in PwBD, though corroboration is needed from other populations. Our findings suggest that modification of pain attitudes presents a possible avenue for interventions to improve pain outcomes and increase patient satisfaction with pain management.
A study on influences of an induced electric field on the Enzymolysis of water caltrop starch by Pullulanase
Authors: Liang Baodong , Yin XuMin , Zhang Wenli , Shang Sang , Zeng Shunde , Wei Haixiang 
Published: February 2024

SummaryOurs is a study on the influences of an induced electric field on the physicochemical properties, structure and in vitro digestion of water caltrop starch by Pullulanase. The distribution range of molecular weight, the average molecular weight of enzyme‐treated starch, and induction electric field decreased gradually. The amylose content and gel strength of starch samples increased gradually when 50 V, 75 V and 100 V induced electric fields were applied, and the solubility and swelling power decreased with the increase of voltage. When the induced voltage was 100 V, amylose content reached 85.78%, gel strength was 198.56 g, the content of slowly digestible starch (SDS) was 41.34%, and the expected glycaemic index (eGI) was the lowest, 1047/1022, and crystallinity was higher than that of other treated samples. When the induced voltage continued to rise to 125 V and 150 V, the amylose content and gel strength of starch began to decrease, corresponding solubility and swelling power began to increase, and the short‐range order and crystallinity of starch were reduced. The content of SDS decreased gradually and eGI increased. This study provides a reference for research on the modification of starch by induction electric field.
Pattern of multimorbidity in middle‐aged and older‐aged people with mild intellectual disability in Australia
Authors: Rutherford Grace , Hussain Rafat , Tait Kathleen 
Published: February 2024

AbstractBackgroundNon‐communicable diseases (NCDs), also known as chronic diseases, now constitute a major proportion of ill‐health across most adult and older populations including in people with intellectual disability. The current paper is a comparative analysis of prevalence of NCDs across mid‐aged and older‐aged people with mild intellectual disability.MethodComparative data comes from two cross‐sectional surveys using similar methodology and timeframes. The analysis sample comprises mid‐aged group (30–50 years, N = 291) and older‐aged group (≥60 years, N = 391).ResultsPeople with mild intellectual disability start developing NCDs in early to mid‐adulthood and increases with age. The mean number of NCDs in mid‐aged group was 0.86 (SD, 0.84) compared to 3.82 in older group (SD, 2.67).ConclusionThere needs to be early identification and management of NCDs using relevant health promotion and preventative measures at optimal intervention points. The training of healthcare professionals needs improvement.
Microfoundations of dynamic new venture partnering capabilities
Authors: Wagner Stephan M. , Kurpjuweit Stefan 
Published: February 2024

AbstractManaging relationships with new venture suppliers require the adaptation of supplier management practices and routines. This research builds upon the dynamic capabilities perspective to explicate the ability to partner effectively with new venture suppliers as a dynamic capability. We argue that new venture partnering capability (NVPC) encompasses sensing, seizing, and transforming capabilities. Firms with sensing capabilities can interpret new ventures' value propositions and then match them to the needs of their business units. Seizing capabilities allow firms to coordinate and develop the relationship with a new venture supplier to capture value. Transforming capabilities enable firms to adapt resources and reconfigure their sensing and seizing capabilities. Our findings suggest that firms accelerate the transformation and strengthen dynamic NVPCs by applying entrepreneurial behavior through high‐quality and regular interactions with new venture suppliers and embedding a dedicated new venture function. We also find that dynamic NVPCs can reside at different levels and that entrepreneurial managers can stimulate the development of organizational NVPCs. In general, we provide further empirical evidence on how buying firms can more effectively leverage the potential of new venture suppliers.
Diet with optimal glutathione supplement improves growth, nonspecific immunity, intestinal microbiota, and antioxidant ability in Micropterus salmoides
Authors: Xiong Chuanyu , Chi Yuyu , Wang Bei , Yi Jianhua , Yu Yongyao , Li Yun , Ye Hua , Yin Jiyuan , Wu Ronghua 
Published: February 2024

AbstractIn this study, Micropterus salmoides were fed with dietary glutathione (GSH, 0, 100, 300, and 500 mg/kg) for 56 days to investigate its effects on growth performance, serum nonspecific immunity, liver antioxidant capacity, tissue morphology, and intestinal microbiota. The results showed that the survival rate, weight gain rate, and specific growth rate and condition factor increased, whereas the feed conversion ratio, hepato‐somatic index, and viscerosomatic index decreased in the GSH groups. Compared with the control group, the serum total protein content significantly increased, whereas the triglyceride and total cholesterol significantly decreased in the 300‐mg/kg dietary GSH group. The activities of lysozyme, alkaline phosphatase, and acid phosphatase were significantly higher in GSH‐supplemented groups, peaking at 300‐mg/kg GSH. GSH supplementation significantly increased total antioxidant capacity and decreased malondialdehyde content, with the most pronounced effects at 300‐mg/kg GSH. Further antioxidant indicators showed that a dietary supplement of 300‐mg/kg GSH significantly increased the activities of superoxide dismutase, glutathione transferase, endogenous glutathione, glutathione reductase, and catalase. At 300‐mg/kg GSH, the liver exhibited improved characteristics with alleviated vacuolation and hepatocyte nuclear shift, and intestine showed enhanced structure with increased villus height and intestinal wall thickness. Additionally, a 300‐mg/kg GSH supplementation improved the diversity of intestinal microbiota, increased the abundance of probiotics such as Bacillus, and inhibited the development of pathogenic bacteria such as Plesiomonas. Overall, the results suggest that the effect of GSH addition on improving growth performance, nonspecific immunity, antioxidant capacity, and intestinal microbiota of M. salmoides is best in the 300‐mg/kg addition group. Based on second‐degree polynomial regression analysis of weight gain, the optimum requirement of dietary GSH in M. salmoides is a 336.84‐mg/kg diet.
Comparison of engineering properties of organic and inorganic coconut: Implications on the design of coir fiber extraction machine
Authors: Pandiselvam Ravi , Manikantan M. R. , Subramanian P. , Khanashyam Anandu Chandra , Shanker M. Anjaly , Surekha R. , Gupta Alka 
Published: February 2024

AbstractCoconut husk is widely used as a source of natural fibers in the tropics. Dehusking and fiber extraction are some of the important unit operations in coir manufacturing. For the development of an efficient and economically viable fiber extraction machine, the engineering properties of conventional and organically grown coconuts were evaluated. Selected engineering properties of whole coconut were investigated. The average true density and bulk density were in the range of 414.63 ± 111.85 to 529.28 ± 123.02 and 161.66 ± 24.41 to 212.23 ± 18.96 kg/m3, respectively. Along with whole coconuts, engineering properties of husk (weight, moisture content, and husk thickness), shell (weight, thickness, bulk density, and moisture content), and kernel parameters (weight, thickness, and moisture content) were also evaluated. The application of organic treatment (T4) exhibited substantial impacts, leading to a higher coconut weight (1.354 kg) as compared to conventional practices (T5), and increased dimensions (158.599 mm diameter and 205.000 mm height) and improved bulk density (190.97 kg/m3) in comparison to other organic treatments. In deshelled coconuts, T4 showcased a higher shell weight (175.667 g) and shell thickness (4.767 mm). The kernel parameters of T4 displayed enhancements, featuring a kernel weight of 314.334 g and a thickness of 11.774 mm. Although the study could not find any correlation between the farming practices and engineering characteristics of coconut fruit, the data presented herein could be utilized for the design and improvisation of efficient fiber extraction machines.Practical ApplicationsDeveloping countries are exploring the possibilities of implementation of organic farming for the production of agro products. Implementation of organic farming not only affects yield but may also change the engineering properties and nutritional characteristics of products. Understanding the engineering properties of food products grown under organic conditions is important for the modification of the design in the existing machineries and/or development of new food processing equipments.
Investigating the impact of woodland placement and percentage cover on flood peaks in an upland catchment using spatially distributed TOPMODEL
Authors: Monger F. , Spracklen D. V. , Kirkby M. J. , Willis T. 
Published: February 2024

AbstractWoodlands can reduce downstream flooding, but it is not well known how the extent and distribution of woodland affects reductions in peak flow. We used the spatially distributed TOPMODEL to simulate peak flow during a 1 in 50 year storm event for a range of broadleaf woodland scenarios across a 2.6 km2 catchment in Northern England. Woodland reduced peak flow by 2.6%–15.3% depending on the extent and spatial distribution of woodland cover. Cross slope and riparian woodland resulted in larger reductions in peak flow, 4.9% and 3.3% for a 10‐percentage point increase in woodland cover respectively, compared to a 2.7% reduction for woodland randomly located across the catchment. Our results demonstrate that increased woodland cover can reduce peak flows during a large storm event and suggest that targeted placement of woodland can maximise the effectiveness of natural flood management interventions.
Revolution of Helicobacter pylori treatment
Authors: Yamaoka Yoshio 
Published: February 2024

AbstractHelicobacter pylori infection is a major global health concern, and its management has witnessed a revolutionary shift with the emergence of antibiotic resistance. In this review, I explore the mechanisms of H. pylori antibiotic resistance and highlight the critical need for susceptibility‐based eradication treatments. The increasing prevalence of antibiotic‐resistant strains requires innovative approaches to combat this resilient pathogen. I also delve into the importance of mass screening as a preventive strategy for early detection and intervention, describing my experience in Bhutan. Additionally, I explore promising alternatives, such as vaccination. The aim of this review is to provide insight into the evolving landscape of H. pylori treatment and highlight the need for a paradigm shift in the approach to combating this persistent bacterial infection.
Challenges for hepatitis B control in Asia‐Pacific areas: Consolidating vaccination and rolling‐out antiviral therapies
Authors: Chen Pei‐Jer 
Published: February 2024

AbstractChronic hepatitis B (CHB) was, and still is, a prevalent liver disease in the world, especially high in the Asia‐Pacific areas. With the advent of preventive vaccines and effective viral suppression drugs and active implementations, CHB has gradually become under control. The world‐wide prevalence reduces from 4.2% in 1980 to 3.2% in 2020 study. CHB patients receiving long‐term antiviral therapies significantly improve the clinical outcomes, saving from end‐stage liver diseases. Despite of these impressive progresses, to meet the WHO sustained development goals (SDG) for CHB control, a 90% reduction of incidence and a 65% reduction of mortality in year 2030, there is still a long way to go. In this review, four ongoing approaches have been proposed: (i) A continuous monitoring of long‐term vaccine efficacy in vaccinated populations; (ii) consolidating the hepatitis B virus vaccination program against vaccine hesitancy and limited resources; (iii) rolling‐out current oral antivirals to more CHB patients not only for diseases treatment but also for infection preventions; and (iv) development of curative therapies, both friendly‐to‐dispense and affordable. A coherent and persevere efforts by the society may succeed and achieve the SDG for CHB in the future.
Patient experiences on the quality of cerebrovascular diseases counselling using digital solutions in hospital—A qualitative research study
Authors: Myllykangas Kirsi , Härkönen Henna , Kääriäinen Maria , Kärppä Mikko , Jansson Miia 
Published: February 2024

AbstractAimTo describe patients' experiences of the quality of counselling to develop new digital counselling solutions for patients with cerebrovascular disease.DesignA descriptive, qualitative approach.MethodsSemi‐structured in‐person interviews were conducted among 22 patients diagnosed with acute cerebrovascular disease and treated as inpatients at a single university hospital in Finland between September 2021 and February 2022. Data were analysed using deductive and inductive content analysis.ResultsThe identified facilitators, barriers and possible solutions for the development of new digital counselling solutions were deductively categorized into five main categories: (1) background factors, (2) resources, (3) implementation, (4) sufficiency, and (5) effects and 12 generic categories. Patients with cerebrovascular diseases worry about symptoms affecting their ability to receive information and valued a supportive atmosphere. Staff should have more time for counselling and use motivational digital counselling solutions in plain language, moderate length and with multimedia content. Patients desired reminders, easy search functions and possibilities for two‐way communication.ConclusionNew digital counselling solutions could be beneficial in supporting the patients' knowledge, emotions and adherence. For the success of such solutions, patients' special needs concerning different levels of cognitive impairment need to be considered.ImpactThe results of this study may benefit healthcare organizations in the development of digital counselling solutions that meet the patients' needs.Reporting MethodWe have adhered to relevant EQUATOR guidelines with the COREQ reporting method.Patient or Public ContributionPatients were involved as the study population.
Association between oxidative stress and chronic orofacial pain and potential druggable targets: Evidence from a Mendelian randomization study
Authors: Zhang Shao‐Hui , Feng Yao , Zhong Meng‐Mei , Xie Jia‐Hao , Xu Wei 
Published: February 2024

AbstractBackgroundOxidative stress indicators affect chronic orofacial pain (COFP), but how to reduce these effects is uncertain.Objectives11 oxidative stress biomarkers were collected as exposures, while four forms of COFP were chosen as outcomes for Mendelian randomization (MR) study.MethodsThe effect estimates between oxidative stress and COFP were calculated using inverse variance‐weighted MR (IVW‐MR). Then, functional mapping and annotation (FUMA) was utilized in order to carry out SNP‐based functional enrichment analyses. In addition, the IVW‐MR method was applied to combine effect estimates when using genetic variants associated with oxidative stress biomarkers as an instrument for exploring potential druggable targets.ResultsThe results indicated that oxidative stress biomarkers (causal OR of uric acid (UA), 0.998 for myofascial pain, 95% CI 0.996–1.000, p < .05; and OR of glutathione transferase (GST), 1.002 for dentoalveolar pain, 95% CI 1.000–1.003, p < .05) were significantly linked with the probability of COFP. Functional analysis also demonstrated that UA and myofascial pain genes were prominent in nitrogen and uracil metabolism, while GST and dentoalveolar pain genes were enriched in glutathione metabolism. Also, the study provided evidence that solute carrier family 2 member 9 (SLC2A9) and glutathione S‐transferase alpha 2 (GSTA2) cause discomfort in the myofascial pain (OR = 1.003, 95% CI 1.000–1.006; p < .05) and dentoalveolar region (OR = 1.001, 95% CI 1.000–1.002; p < .05), respectively.ConclusionsIn conclusion, this MR study indicates that genetically predicted myofascial pain was significantly associated with decreased UA and dentoalveolar pain was significantly associated with increased GST level. SLC2A9 inhibitor and GSTA2 inhibitor were novel chronic orofacial pain therapies and biomarkers, but clinical trials are called to examine if these oxidative biomarkers have the protective effect against orofacial pain, and further research are needed to explore the underlying mechanisms.
Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review
Authors: Yao Nan , Ma Chenyuan , Dou Ruixue , Shen Chao , Yuan Ye , Li Wei , Qu Jun 
Published: February 2024

SummaryDespite the high prevalence and significant health burden of obstructive sleep apnea (OSA), its underlying pathophysiology remains incompletely understood. This comprehensive review explores the emerging connection between vitamin D deficiency and OSA, discusses potential mechanisms underlying this association, and explores the therapeutic implications of these findings. Recent research has consistently highlighted the high incidence of vitamin D deficiency among patients with OSA, which often occurs independently of geographical location. This suggests that factors beyond lack of sunlight exposure may be involved. This review also discusses how reduced vitamin D may be associated with more severe manifestations of OSA. In addition, it explores the potentiality of using vitamin D supplements as a therapeutic strategy for OSA, noting that some studies have found improvements in sleep quality and a reduction in OSA severity. Potential mechanisms are proposed, including the role of vitamin D deficiency in promoting inflammation, oxidative stress, hypoxia, impairing immune function, muscle function, and gene polymorphism of vitamin D receptors, all of which could contribute to the pathogenesis of obstructive sleep apnea. The paper underscores the need for future research to validate these observations, to determine optimal vitamin D supplementation dosage and duration, to explore potential side effects and risks, and to investigate potential interactions with other treatments.
Association of a novel dystrophin (DMD) genetic nonsense variant in a cat with X‐linked muscular dystrophy with a mild clinical course
Authors: Muto Harunobu , Yu Yoshihiko , Chambers James K. , Coghill Lyndon M. , Nakamura Yasuharu , Uchida Kazuyuki , Lyons Leslie A. 
Published: February 2024

AbstractX‐linked muscular dystrophy in cats (FXMD) is an uncommon disease, with few reports describing its pathogenic genetic variants. A 9‐year‐old castrated male domestic shorthair cat was presented with persistent muscle swelling and breathing difficulty from 3 years of age. Serum activity of alanine aminotransferase, aspartate transaminase, and creatine kinase were abnormally high. Physical and neurological examinations showed muscle swelling in the neck and proximal limb, slow gait, and occasional breathing difficulties. Electromyography showed pseudomyotonic discharges and complex repetitive discharges with a “dive‐bomber” sound. Histopathology revealed muscle necrosis and regeneration. Whole‐genome sequencing identified a novel and unique hemizygous nonsense genetic variant, c.8333G > A in dystrophin (DMD), potentially causing a premature termination codon (p.Trp2778Ter). Based on a combination of clinical and histological findings and the presence of the DMD nonsense genetic variant, this case was considered FXMD, which showed mild clinical signs and long‐term survival, even though immunohistochemical characterization was lacking.
Farm strategies and characteristics influencing profitability in Nigerian catfish aquaculture: Lessons on resilience during economic crisis and COVID‐type shock
Authors: Olagunju Olanrewaju Femi , Kristofersson Dadi , Tómasson Tumi , Kristjánsson Theódór 
Published: February 2024

AbstractSince the early 2000s, aquaculture in Nigeria has grown exponentially. African catfish aquaculture was a major contributor to this expansion. However, a fall in output started in 2015, mostly due to challenging economic conditions which affected farmer's profitability. This challenge has been exacerbated by the COVID‐19 pandemic. Notwithstanding, some catfish farms remained profitable. This study investigates the profitability strategies that aid farmers' resilience in times of both economic distress and COVID‐type shock. Data from 609 randomly sampled farms across the country were verified and included in the study covering 1118 operations for the pre‐COVID and COVID periods. Budgetary analysis was done, and stepwise regression was used to identify factors that most contribute to profitability. These factors were ranked by average profit per kilogram and grouped. The profitability during the periods was influenced by factors within the subcategories of scale of operation, experience, targeted markets, ownership, and pond type. Engagement in other agricultural ventures favored profitability during the COVID period. Profitable and non‐profitable groups were further characterized based on their technical and financial indicators. Explored strategies for profitability, including the operation scale, marketing tactics, cost‐cutting, and innovative production techniques all proved successful during economic distress and the pandemic.