bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant high‐dose interferon for cutaneous melanoma is most beneficial for patients with early stage III disease
Authors: Anaya Daniel A. , Xing Yan , Feng Lei , Huang Xuelin , Camacho Luis H. , Ross Merrick I. , Gershenwald Jeffrey E. , Lee Jeffrey E. , Mansfield Paul F. , Cormier Janice N. 
Published: March 2008

AbstractBACKGROUND.Evidence from randomized trials in the pre‐sentinel lymph node biopsy era indicate that adjuvant treatment with high‐dose interferon‐α (IFN) increases recurrence‐free survival (RFS) in patients with high‐risk melanoma. However, to the authors' knowledge, the role of this treatment in selected patients with early stage III disease has not been well studied.METHODS.The clinical and pathologic characteristics of 486 patients undergoing surgical treatment for stage III melanoma were evaluated and the authors compared outcomes for those given adjuvant treatment with IFN with those patients who had surgery alone. A particular focus was on the effect of IFN therapy on RFS and overall survival (OS) among those patients with stage IIIA disease.RESULTS.The median follow‐up for the entire cohort was 5.2 years; the 5‐year RFS and OS rates for the entire group were 41% and 53%, respectively. Adjuvant IFN was given to 141 patients (29%). On multivariate analysis, IFN was found to be the only independent predictor for RFS in patients with stage IIIA disease (hazards ratio of 0.4; 95% confidence interval, 0.2–0.9 [P = .02]). IFN was not found to be associated with increased RFS in patients with more advanced lymph node disease (stage IIIB and stage IIIC). IFN appeared to have no effect on OS in any patient with stage III disease.CONCLUSIONS.Adjuvant treatment with IFN improves RFS in melanoma patients with early stage III disease. The results of the current study should help guide management when considering adjuvant treatment for these patients. Cancer 2008. © 2008 American Cancer Society.
Isolation of an Intermediate in the Platination of p‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug (Eur. J. Inorg. Chem. 8/2008)
Authors: Quiroga Adoración G. , Cubo Leticia , Miguel Pablo J. Sanz , Moneo Victoria , Carnero Amancio , Navarro‐Ranninger Carmen 
Published: March 2008

AbstractThe cover picture shows the crystal structure of a novel intermediate in the p‐nitroacetophenone 4‐methylthiosemicarbazone platination, [PtL1(L1H2)], with potential application as an antitumoral drug. The complex is above an NCI‐H460 cell culture background labelled to discriminate between live and dead cells by confocal microscopy. Details are discussed in the Short Communication by A. G. Quiroga et al. on p. 1183 ff.
Recent Progress in Diazirine‐Based Photoaffinity Labeling
Authors: Hashimoto Makoto , Hatanaka Yasumaru 
Published: March 2008

AbstractAs a result of recent developments in molecular biology, the investigation of biofunctional machinery at ligand‐accepting interfaces has become one of the challenging and important subjects in the post‐genome field. The technique of photoaffinity labeling has become increasingly appreciated as a powerful methodology for this purpose. This microreviewfocuses on the synthesis of 3‐phenyl‐3‐(trifluoromethyl)diazirine, one of the most promising photophores, and its application to biomolecules.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Chromium‐Thiophene‐salen‐Based Polymers for Heterogeneous Asymmetric Hetero‐Diels–Alder Reactions
Authors: Zulauf Anaïs , Mellah Mohamed , Guillot Régis , Schulz Emmanuelle 
Published: March 2008

AbstractNew chiral thiophene‐salen ligands have been synthesized and the corresponding chromium complexes proved to beefficient catalysts for promoting asymmetric hetero‐Diels–Alder reactions with good activities and high enantioselectivities (up to 88 % ee). These complexes were successfully electropolymerized to give chiral polymers as insoluble powders for use in asymmetric heterogeneous catalysis. When engaged in successive hetero‐Diels–Alder reactions, they afforded the expected products in high yield and enantioselectivity showing no loss of efficiency for up to 15 cycles. A chiral chromium‐salen‐thiophene polymer was also successfully used in a multi‐substrate procedure in which a new, structurally different aldehyde was introduced for each reuse to afford the desired pyranone in its pure form. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Biostratigraphic zonation and correlation of Mississippian rocks in Western Europe: some case studies in the late Viséan/Serpukhovian
Authors: Somerville Ian D. 
Published: March 2008

AbstractIn the Mississippian in Western Europe, biostratigraphic zonation and correlation of sequences has been refined using a combination of faunal and floral groups. In deep‐water basins and on shelves advances have been made in recognizing evolutionary lineages of conodonts, particularly in the early Viséan to Serpukhovian, for example theGnathodus praebilineatus ‐ G. bilineatus bilineatus ‐ G. bilineatus bollandensislineage, which is closely tied to ammonoid zones in the Culm facies of Western and Central Europe, and theLochriea saharae ‐ L. commutata ‐ L. nodosa ‐ L. zieglerilineage. Moreover, progress has been made in recognizing the Upper Viséan/Serpukhovian boundary, based on the first appearance datum (FAD) ofLochriea ziegleri.Greater precision in the dating and correlation of shallow‐water platform facies has been achieved using foraminiferans. Although evolutionary developments in the Archaediscidae are still of major importance in terms of biostratigraphic dating, alternative lineages have been proposed recently for the late Asbian/Brigantian (late Viséan) interval, involving theCribrospira ‐ Bradyina ‐ Parajanischewskina ‐ Janischewskinalineage. These large cribrate complexed‐walled forms are widely recognized throughout Western Europe. The base of the Viséan has recently been defined in South China using foraminiferans with the FAD ofEoparastaffella simplexin the lineageEoparastaffella ovalis ‐ E. simplex. The same criterion has been used to define the base of the Viséan (base of emended Moliniacian) in Belgium.Recent studies in Britain, Ireland, France, Spain and Poland have demonstrated that in the Upper Viséan many calcareous algal taxa and problematica are widespread in their distribution throughout the western Palaeotethys Realm. Moreover, five algal assemblages can be distinguished, based either on the first appearance of certain taxa or their acme developments, such asFalsocalcifolium punctatumandCalcifolium okense. In addition, there have been new discoveries in the Brigantian and Serpukhovian of algal taxa and problematica such asArchaeolithophyllum, ParaepimastoporaandClaracrustathat were regarded previously as being restricted to the Pennsylvanian‐Permian interval.Advances in rugose coral biostratigraphy have also been made in the upper Tournaisian and Upper Viséan, particularly using dissepimented taxa which occur in shallow‐water platforms. The presence of uraliniids andKeyserlingophyllumin the upper Tournaisian of Western Europe (Belgium) are also recognized in South China and Siberia. In the Upper Viséan, refinements in zonation have been made using well‐defined colonial and solitary species and species groups belonging to the families Lithostrotionidae and Axophyllidae and solitary taxa of the families Aulophyllidae and Cyathopsidae which are recognized throughout the western Palaeotethys. Copyright © 2008 John Wiley & Sons, Ltd.
Kaolin: A recyclable catalyst for the synthesis of 1,5‐benzodiazepines
Authors: Heravi Majid M. , Derikvand Fatemeh , Ranjbar Leila , Oskooie Hossein A. 
Published: March 2008

Abstract2,3‐Dihydro‐1H‐1,5‐benzodiazepines are synthesized by the condensation of o‐phenylenediamine and various ketones in the presence of kaolin as a recyclable catalyst in dichloroethane. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:215–217, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20354
Synthesis, characterization, and biological activity of phosphorylated/thiophosphorylated compounds of 2‐substituted benzimidazoles
Authors: Pareek Sonu , Vyas Sushma , Seth G. , Vyas P. C. 
Published: March 2008

AbstractA series of phosphorylated and thiophosphorylated compounds of 2‐substituted benzimidazoles have been synthesized by the reaction of POCl3 and PSCl3 with 2‐substituted benzimidazoles in different molar ratios. The compounds have been characterized by elemental analyses, infrared, and 1H NMR and 31P NMR spectral studies. These compounds were found to be insecticidal when tested against Periplenata americana. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:154–157, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20385
Efficient synthesis of 5H‐thiazolo[3,2‐a]pyrimidines from reactions of 3,4‐dihydropyrimidine‐thiones with α‐bromoacetone in aqueous media
Authors: Quan Zheng‐Jun , Zhang Zhang , Wang Jun‐Ke , Wang Xi‐Cun , Liu Ya‐Juan , Ji Peng‐Yan 
Published: March 2008

AbstractAn efficient and convenient method for thiazolo[3,2‐a]pyrimidines from cyclization reaction of dihydropyrimidine‐thiones with α‐bromoacetone in aqueous media is described. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:149–153, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20386
Synthesis of cyclic aminomethylphosphonates and aminomethyl‐arylphosphinic acids by an efficient microwave‐mediated phospha‐mannich approach
Authors: Keglevich György , Szekrényi Anna , Sipos Melinda , Ludányi Krisztina , Greiner István 
Published: March 2008

AbstractMicrowave‐assisted condensation of 1,3,‐2‐dioxaphosphinane 2‐oxide (1), paraformaldehyde and secondary amines including 5‐ and 6‐membered N‐heterocycles at 55°C gave cyclic aminomethylphosphonates (2), whereas an analogous reaction involving dibenzo[c.e][1,2]oxaphosphinane 2‐oxide (3) resulted in the corresponding aminomethyl‐2‐(2′‐hydroxybiphenyl)phosphinic acids (4) as a consequence of a hydrolytic ring opening following the condensation. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:207–210, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20387
Syntheses of 1‐thio‐D‐xylose and D‐ribose esters of diorganoarsinous acids and their anticancer activity
Authors: Gao Mingzhang , Chen Yiwen , Tan Songde , Reibenspies Joseph H. , Zingaro Ralph A. 
Published: March 2008

AbstractSeveral thio‐D‐xylose and D‐ribose esters of dialkylarsinous acids have been synthesized. The crystal structure of 1‐S‐dimethylarsino‐β‐D‐xylopyranose, 7a, has been obtained. Growth inhibition studies of about 60 strains of human cancer cells have been obtained in vitro for compounds 6a, 7a, 13, and 14. The results reveal that these compounds display a strong inhibition to subpanels of leukemia cells in vitro and high selectivity in inhibiting the growth of cancer cells. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:199–206, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20388
Sulfamic acid as efficient and reusable catalytic system for the synthesis of pyrrole, furan, and thiophene derivatives
Authors: Luo Haitang , Kang Yuru , Li Qi , Yang Liming 
Published: March 2008

AbstractSulfamic acid has been utilized for the first time as an efficient and reusable catalytic system for the synthesis of heteroaromatics such as pyrrole, furan, and thiophene derivatives from 1,4‐diketones. This new procedure offers significant improvements in the reaction rates and yields in a shorter reaction time and a lower reaction temperature contrasted with the reported results. The recovered catalyst can be reused for subsequent runs with only a gradual decrease in activity. The most important feature is that the reaction process is homogeneous whereas the separation process is heterogeneous, which is often seen in other catalysts, and so it is a good character for technical application. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:144–148, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20389
Synthesis and structure of complexes of phosphorus pentachloride with 4‐dimethylaminopyridine and n‐methylimidazole
Authors: Pipko Sergey E. , Bezgubenko Ludmila V. , Sinitsa Anatoliy D. , Rusanov Eduard B. , Kapustin Evgeniy G. , Povolotskii Mark I. , Shvadchak Volodymyr V. 
Published: March 2008

AbstractComplexes of phosphorus pentachloride with 4‐dimethylaminopyridine and N‐methylimidazole were synthesized. The molecular structure of the phosphorus pentachloride complex with N‐methylimidazole was determined by single‐crystal X‐ray diffraction. In the cationic part of the complex, the phosphorus atom possesses four PCl bonds within the range 2.109–2.148 Å and two cis‐P–N bonds (1.811 and 1.832 Å) with N‐methylimidazole and exhibits slightly distorted octahedral coordination with angles at phosphorus atom in the range 87.57°–91.50°. The relative stability of the cis and trans conformations of the complex was studied by DFT calculations. The chemical properties and reactivity of the compounds obtained are determined; their utility as condensing agents in the synthesis of amides from acids and amines was shown. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:171–177, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20392
Stereoselective synthesis of trisubstituted alkenes containing (Z)‐allylthio units from the acetates of Baylis–Hillman adducts
Authors: Liu Yunkui , Xu Danqian , Xu Zhenyuan , Zhang Yongmin 
Published: March 2008

AbstractA series of trisubstituted alkenes containing (Z)‐allylthio moieties as key structural units, that is, sodium (Z)‐allyl thiosulfates, symmetrical di(Z‐allyl) sulfides, and di(Z‐allyl) disulfides, unsymmetrical diallyl sulfides were prepared in moderate to good yields via chemical transformations from the acetates of Baylis‐‐Hillman adducts. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:188–198, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20394
1,3,6‐Azadiphosphacycloheptanes: A novel type of heterocyclic diphosphines
Authors: Karasik Andrey A. , Balueva Anna S. , Moussina Elvira I. , Naumov Roman N. , Dobrynin Alexey B. , Krivolapov Dmitry B. , Litvinov Igor A. , Sinyashin Oleg G. 
Published: March 2008

AbstractThe novel type of seven‐membered cyclic diphosphines, namely 1,3,6‐azadiphosphacycloheptanes, has been synthesized by condensation of 1,2‐bis(phenylphosphino)ethane, formaldehyde, and primary amines (aniline,p‐toluidine, benzylamine, and 5‐aminoisophthalic acid) as a mixture of rac‐ and meso‐stereoisomers. The structures of rac‐stereoisomers ofN‐tolyl andN‐(3′,5′‐dicarboxyphenyl)‐substituted diphosphines were investigated by X‐ray crystal structure analyses. The stereoisomers ofN‐(3′,5′‐dicarboxyphenyl)‐substituted compound were separated at a preparative scale, and their platinum(II) dichloride complexes were obtained. The corresponding meso‐isomer readily formsP,P‐chelate complex with [PtCl2(cod)], whereas the rac‐stereoisomer forms oligomeric complex. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:125–132, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20397
Facile synthesis of selenocarboxamides from nitriles using Se/CO/H2O under atmospheric pressure
Authors: Chen Yahong , Tian Fengshou , Song Maoping , Lu Shiwei 
Published: March 2008

AbstractAromatic and aliphatic nitriles can be conveniently converted into the corresponding selenocarboxamides with Se/CO/H2O under atmospheric pressure without use of a base. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:211–214, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20398
Synthesis of 1‐(phenylsulfanyl/phenoxy)‐3H‐naptho[1,2,3‐de]quinoline‐2,7‐diones
Authors: Etukala Jagan Reddy , Yadav J. S. 
Published: March 2008

AbstractA convenient method is devised to synthesize 1‐(phenylsulfanyl/phenoxy)‐3H‐naptho[1,2,3‐de]quinoline‐2,7‐dione analogs in high yield for the first time by condensation of 2‐bromo‐N‐(9,10‐dixo‐dihydro‐anthracen‐1‐yl)‐acetamide with benzenethiol/phenol using potassium carbonate. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:221–227, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20399
MnCl2‐Promoted synthesis of quinoxaline derivatives at room temperature
Authors: Heravi Majid M. , Bakhtiari Khadijeh , Oskooie Hossein A. , Taheri Shima 
Published: March 2008

AbstractMnCl2 efficiently catalyzes the condensation of o‐phenylenediamine derivatives with 1,2‐diketones at room temperature to afford the corresponding quinoxaline derivatives in high yields. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:218–220, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20401
Novel routes to aminophosphonic acids: Interaction of dimethyl H‐phosphonate with hydroxyalkyl carbamates
Authors: Troev K. , Koseva N. , Hägele G. 
Published: March 2008

AbstractIt was found that the reaction of dimethyl H‐phosphonate (1) with 2‐hydroxyalkyl‐N‐2′‐hydroxyalkyl carbamates at 135°C includes several chemical reaction steps: (i) chemical transformations of 1‐methyl‐2‐hydroxyethyl‐N‐2′‐hydroxyethyl carbamate (2) and 2‐methyl‐2‐hydroxyethyl‐N‐2′‐hydroxyethyl carbamate (3); (ii) transesterification of dimethyl H‐phosphonate with 2 and 3, and with secondary hydroxyl‐containing compounds that are formed during the course of the chemical transformation of 2‐hydroxyalkyl‐N‐2′‐hydroxyalkyl carbamates; (iii) hydrolysis of 1 and dialkyl H‐phosphonates, formed via transesterification of 1 with secondary hydroxyl‐containing compounds. The interaction was studied by means of 1H, 13C, 31P NMR, and FAB mass spectroscopy. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:119–124, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20404
Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder
Authors: Adams David H. , Close Sandra , Farmen Mark , Downing AnnCatherine M. , Breier Alan , Houston John P. 
Published: March 2008

AbstractObjectiveTo test association of dopamine receptor D3 (DRD‐3) gene polymorphisms with olanzapine response in genetic samples from a registration phase clinical trial.MethodsEighty‐eight acutely ill patients with schizophrenia or schizoaffective disorder were genotyped for ser‐9‐gly (rs6280) and 23 other polymorphisms within the DRD‐3 gene. Allelic association of clinical response (mean baseline‐ to‐endpoint reduction in Positive and Negative Syndrome Scale [PANSS] total and subscores) over 6 weeks of olanzapine treatment was assessed using repeated measures analysis of variance.ResultsSer‐9‐gly genotypes were associated with differences in PANSS total score improvement from baseline to 6 weeks (p = 0.021). This association was most notable for improvement in positive symptoms (p = 0.0001), with patients with gly/gly genotype significantly more responsive. More patients with the gly/gly genotype had greater positive symptom remission (endpoint rating of minimal or none on all PANSS positive items, 39.1%) compared with patients with gly/ser and ser/ser genotypes (13.8%;p = 0.033). DRD‐3 polymorphisms in disequilibrium with ser‐9‐gly were also significantly associated with greater positive symptom improvement (p = 0.0009–0.021), and one not in complete linkage disequilibrium, with lesser improvement (p = 0.027).ConclusionsGly/gly DRD‐3 genotype predicted statistically and clinically significantly better acute positive symptom reduction compared with other ser‐9‐gly genotypes in patients treated with olanzapine. Copyright © 2008 John Wiley & Sons, Ltd.
Nonlinear laser imaging of skin lesions
Authors: Cicchi R. , Sestini S. , De Giorgi V. , Massi D. , Lotti T. , Pavone F. S. 
Published: March 2008

AbstractWe investigated different kinds of human ex‐vivo skin samples by combined two‐photon intrinsic fluorescence (TPE), second‐harmonic generation microscopy (SHG), fluorescence lifetime imaging microscopy (FLIM), and multispectral two‐photon emission detection (MTPE). Morphological and spectroscopic differences were found between healthy and pathological skin samples, including tumors. In particular, we examined tissue samples from normal and pathological scar tissue (keloid), and skin tumors, including basal cell carcinoma (BCC), and malignant melanoma (MM). By using combined TPE‐SHG microscopy we investigated morphological features of different skin regions. Further comparative analysis of healthy skin and neoplastic samples was performed using FLIM, and MTPE. Finally, we demonstrated the use of methyl‐aminolevulinate as a contrast agent to increase the contrast in BCC border detection. The results obtained represent further support for in‐vivo noninvasive imaging of diseased skin. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Phenotypic variations of TRAIL sensitivity in cloned populations of prostate cancer cells
Authors: Cross N.A. , Waterman E.A. , Jokonya N. , Fowles A. , Buckle C.H. , Phillips J. , Holen I. , Hamdy F.C. , Eaton C.L. 
Published: March 2008

AbstractFactors that regulate the induction of apoptosis of tumour cells are potential candidates for therapeutic intervention for the majority of cancers. Studying modifiers of apoptotic responses, such as members of the tumour necrosis factor receptor superfamily, may give clues as to how induction of apoptosis in tumours could be maximized to enhance the benefit of treatment regimes. Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL) is a promising anti‐tumour molecule since its activity is specific for tumour cell populations. TRAIL binds to death receptors, inducing apoptosis in susceptible cells. The mechanisms which determine whether tumour cells are susceptible to TRAIL are unclear, and several mechanisms have been proposed, including expression of osteoprotegerin (OPG), decoy receptors, and factors that affect intracellular signalling of pro‐apoptotic molecules, such as c‐FLIP. Here we show that experiments to modulate the activity of one of these factors, OPG, by over‐expression and also by stable knockdown of OPG expression, alters the TRAIL sensitivity of PC3 prostate cancer cells. However we show that some observed effects, which appear to support the hypothesis that OPG prevents TRAIL‐induced apoptosis of tumour cells, may be due to variation of the TRAIL response of sub‐clones of tumour cells, even within a cloned population. These results highlight potential limitations of experiments designed to test contribution of factors affecting intrinsic apoptosis susceptibility using cloned tumour cell populations. J. Cell. Biochem. 104: 1452–1464, 2008. © 2008 Wiley‐Liss, Inc.
On a question of Sós about 3‐uniform friendship hypergraphs
Authors: Hartke Stephen G. , Vandenbussche Jennifer 
Published: March 2008

AbstractThe well‐known Friendship Theorem states that if G is a graph in which every pair of vertices has exactly one common neighbor, then G has a single vertex joined to all others (a “universal friend”). V. Sós defined an analogous friendship property for 3‐uniform hypergraphs, and gave a construction satisfying the friendship property that has a universal friend. We present new 3‐uniform hypergraphs on 8, 16, and 32 vertices that satisfy the friendship property without containing a universal friend. We also prove that if n ≤ 10 and n ≠ 8, then there are no friendship hypergraphs on n vertices without a universal friend. These results were obtained by computer search using integer programming. © 2008 Wiley Periodicals, Inc. J Combin Designs 16: 253–261, 2008