bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric disorders and mental health service use in patients with advanced cancer
Authors: Kadan‐Lottick Nina S. , Vanderwerker Lauren C. , Block Susan D. , Zhang Baohui , Prigerson Holly G. 
Published: November 2005

AbstractBACKGROUNDPsychological morbidity has been proposed as a source of distress in cancer patients. This study aimed to: 1) determine the prevalence of diagnosable psychiatric illnesses, and 2) describe the mental health services received and predictors of service utilization in patients with advanced cancer.METHODSThis was a cross‐sectional, multi‐institutional study of 251 eligible patients with advanced cancer. Eligibility included: distant metastases, primary therapy failure, nonpaid caregiver, age ≥20 years, stamina for the interview, English or Spanish‐speaking, and adequate cognitive ability. Trained interviewers administered the Structured Clinical Interview for the Diagnostic Statistical Manual IV (DSM‐IV) modules for Major Depressive Disorder, Generalized Anxiety Disorder, Panic Disorder, Post‐Traumatic Stress Disorder, and a detailed questionnaire regarding mental health service utilization.RESULTSOverall, 12% met criteria for a major psychiatric condition and 28% had accessed a mental health intervention for a psychiatric illness since the cancer diagnosis. Seventeen percent had discussions with a mental health professional; 90% were willing to receive treatment for emotional problems. Mental health services were not accessed by 55% of patients with major psychiatric disorders. Cancer patients who had discussed psychological concerns with mental health staff (odds ratio [OR] = 19.2; 95% confidence interval [95% CI], 8.90–41.50) and non‐Hispanic white patients (OR = 2.7; 95% CI, 1.01–7.43) were more likely to receive mental health services in adjusted analysis.CONCLUSIONSAdvanced cancer patients experience major psychiatric disorders at a prevalence similar to the general population, but affected individuals have a low rate of utilizing mental health services. Oncology providers can enhance utilization of mental health services, and potentially improve clinical outcomes, by discussing mental health concerns with their patients. Cancer 2005. © 2005 American Cancer Society.
BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases
Authors: Pal Tuya , Permuth‐Wey Jenny , Betts Judith A. , Krischer Jeffrey P. , Fiorica James , Arango Hector , LaPolla James , Hoffman Mitchell , Martino Martin A. , Wakeley Katie , Wilbanks George , Nicosia Santo , Cantor Alan , Sutphen Rebecca 
Published: November 2005

AbstractBACKGROUNDIt is believed that BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are scant data on the prevalence and spectrum of mutations, genotype/phenotype correlations, tumor histology, and family history characteristics. To address this gap, the authors conducted a population‐based study of 232 incident epithelial ovarian carcinomas in the Tampa Bay area.METHODSGenetic testing for the BRCA1 and BRCA2 genes was performed through full sequencing and BRCA1 rearrangement testing.RESULTSOf 209 women with invasive ovarian carcinoma, 32 women (15.3%) had mutations in BRCA1 or BRCA2, including 20 BRCA1 mutations and 12 BRCA2 mutations. Of the BRCA2 mutations, 58% were outside the “ovarian cancer cluster region” (OCCR). Variants of uncertain significance were detected in 8.2% of women with invasive ovarian carcinoma. No mutations were identified in women with borderline or invasive mucinous tumors. Among the BRCA mutation‐positive women, 63% had serous tumors. A family history of breast and/or ovarian carcinoma was reported in 65%, 75%, and 43.5% of relatives of BRCA1 carriers, BRCA2 carriers, and non‐BRCA1/BRCA2 carriers, respectively.CONCLUSIONSThe data from this study suggested that 1) previous studies may have underestimated the frequency of BRCA1 and BRCA2 mutations in ovarian carcinomas, especially outside the OCCR; 2) it may be reasonable to offer genetic counseling to any woman with an invasive, nonmucinous epithelial ovarian tumor; and 3) among patients with invasive ovarian carcinoma, family history is not sufficiently accurate to predict mutation status. Cancer 2005. © 2005 American Cancer Society.
Five genes from chromosomal band 8p22 are significantly down‐regulated in ovarian carcinoma
Authors: Pils Dietmar , Horak Peter , Gleiss Andreas , Sax Cornelia , Fabjani Gerhild , Moebus Volker J. , Zielinski Christoph , Reinthaller Alexander , Zeillinger Robert , Krainer Michael 
Published: November 2005

AbstractBACKGROUNDLoss of heterozygosity on chromosomal band 8p22 is a common event in several epithelial tumors including ovarian carcinoma. So far, no clear evidence for a tumor suppressor gene (TSG) in this region has been found.METHODSOn the basis of publicly available expression data in ovarian tissues, the authors selected the eight most noteworthy genes from 8p22 (DLC1, N33, ZDHHC2, FLJ32642, PDGFRL, MTSG1, PCM1, and EFA6R) for a detailed expression analysis in 58 primary ovarian carcinoma tissues and in 38 ovarian cancer cell lines by using quantitative real‐time reverse transcriptase‐polymerase chain reaction (qRT‐PCR). Expression data were correlated to various clinicopathologic characteristics and survival.RESULTSTwo genes showed a significantly (P< 0.05) lower expression in grade 3 tumors compared with tumors of lower grade (N33) or compared with normal controls and tumors with lower grade (EFA6R). Expression of N33 and EFA6R seems to have an impact on survival, in particular when the combined expression of both genes was used as predictive factor (P< 0.003). In addition, N33 and EFA6R showed a complete loss of expression in several ovarian cancer cell lines. Three genes (FLJ32642, MTSG1, and PCM1) had a significantly (P< 0.001, P< 0.004, and P< 0.001) lower expression in primary ovarian carcinoma compared with controls (ovarian tissues and cysts).CONCLUSIONSTwo to five new potential tumor suppressor or antagonizing gene candidates (N33 and EFA6R with impact on survival, and potentially FLJ32642, MTSG1, and PCM1) for ovarian carcinoma, were identified from the chromosomal band 8p22 and are promising candidates for further functional analysis in ovarian carcinoma. Cancer 2005. © 2005 American Cancer Society.
An adaptive parallel query processing middleware for the Grid
Authors: Da Silva V. F. V. , Dutra M. L. , Porto F. , Schulze B. , Barbosa A. C. , de Oliveira J. C. 
Published: November 2005

AbstractGrid services provide an important abstract layer on top of heterogeneous components (hardware and software) that take part in a Grid environment. In this scenario, applications such as scientific visualization require access to data of non‐conventional data types, such as fluid path geometry, and the evaluation of special user programs and algebraic operators, such as spatial hash‐join, on these data. In order to support such applications we are developing a Configurable Data Integration Middleware System for the Grid (CoDIMS‐G). CoDIMS‐G provides a query execution environment adapted to the heterogeneity and variations found in a Grid environment by offering a node scheduling algorithm and an adaptive query execution strategy. The latter both adapts to performance variations in a scheduled node and deals efficiently with repetitive evaluation of a query execution plan fragment, as needed for computing a particle's, trajectory. Copyright © 2005 John Wiley & Sons, Ltd.
IQ‐Services: network‐aware middleware for interactive large‐data applications
Authors: Cai Zhongtang , Eisenhauer Greg , He Qi , Kumar Vibhore , Schwan Karsten , Wolf Matthew 
Published: November 2005

AbstractIQ‐Services are application‐specific, resource‐aware code modules executed by data transport middleware. They constitute a ‘thin’ layer between application components and the underlying computational and communication resources. This layer implements the data manipulations necessary to permit wide‐area collaborations to proceed smoothly in the presence of dynamic resource variations. IQ‐Services interact with the application and resource layers via dynamic performance attributes, and end‐to‐end implementations of such attributes also permit clients to interact with data providers. The joint middleware/resource and provider/consumer interactions implemented with performance attributes may be used to realize effective methods for managing the data flows in the large‐data, distributed Grid applications targeted by our research. Experimental results in this paper demonstrate substantial performance improvements. These are attained by coordinating network‐level with service‐level adaptations of the data being transported and by permitting end users to dynamically deploy and use application‐specific services for manipulating data in ways suitable for their current needs. Copyright © 2005 John Wiley & Sons, Ltd.
A static resource allocation framework for Grid‐based streaming applications
Authors: Chen Liang , Agrawal Gagan 
Published: November 2005

AbstractA number of applications increasingly rely on, or can potentially benefit from, analysis and monitoring ofdata streams. To support the processing of streaming data in a Grid environment, we have been developing a middleware system called GATES (Grid‐based AdapTive Execution on Streams). Our target applications are those involving high‐volume data streams and requiring distributed processing of data arising from a distributed set of sources. This paper addresses the problem of resource allocation in the GATES system. Although resource discovery and resource allocation have been active topics in Grid community, the pipelined processing and real‐time constraint required by distributed streaming applications pose new challenges. We present a resource allocation algorithm that is based on minimal spanning trees. We evaluate the algorithm experimentally and demonstrate that it results in configurations that are very close to optimal, and significantly better than most other possible configurations. Copyright © 2005 John Wiley & Sons, Ltd.
Resource allocation for remote desktop sessions in Utility Grids
Authors: Talwar Vanish , Agarwalla Bikash , Basu Sujoy , Kumar Raj , Nahrstedt Klara 
Published: November 2005

AbstractEmerging large‐scale utility computing systems such as Grids promise computing and storage to be provided to end users as a utility. System management services deployed in the middleware are a key to enabling this vision. Utility Grids provide a challenge in terms of scale, dynamism and heterogeneity of resources and workloads. In this paper, we present a model‐based architecture for resource allocation services for Utility Grids. The proposed service is built in the context of interactive remote desktop session workloads and takes application performance QoS models into consideration. The key design guidelines are hierarchical request structure, application performance models, remote desktop session performance models, site admission control, multi‐variable resource assignment system and runtime session admission control. We have also built a simulation framework that can handle mixed batch and remote desktop session requests, and have implemented our proposed resource allocation service into the framework. We present some results from experiments using the framework. Our proposed architecture for resource allocation services addresses the needs of emerging utility computing systems and captures the key concepts and guidelines for building such services in these environments. Copyright © 2005 John Wiley & Sons, Ltd.
Adsorption of Amyloid β‐Peptide at Polymer Surfaces: A Neutron Reflectivity Study
Authors: Rocha Sandra , Krastev Rumen , Thünemann Andreas F. , Pereira M. Carmo , Möhwald Helmuth , Brezesinski Gerald 
Published: November 2005

AbstractThe adsorption of amyloid β‐peptide at hydrophilic and hydrophobic modified silicon–liquid interfaces was characterized by neutron reflectometry. Distinct polymeric films were used to obtain noncharged (Formvar), negatively (sodium poly(styrene sulfonate)) and positively charged (poly(allylamine hydrochloride)) hydrophilic as well as hydrophobic surfaces (polystyrene and a polysiloxane–dodecanoic acid complex). Amyloid β‐peptide was found to adsorb at positively charged hydrophilic and hydrophobic surfaces, whereas no adsorbed layer was detected on hydrophilic noncharged and negatively charged films. The peptide adsorbed at the positively charged film as patches, which were dispersed on the surface, whereas a uniform layer was observed at hydrophobic surfaces. The thickness of the adsorbed peptide layer was estimated to be approximately 20 Å. The peptide formed a tightly packed layer, which did not contain water. These studies provide information about the affinity of the amyloid β‐peptide to different substrates in aqueous solution and suggest that the amyloid fibril formation may be driven by interactions with surfaces.
Energy‐Transfer Efficiency in Stacked Oligo(p‐phenylene vinylene)s: Pronounced Effects of Order
Authors: Hoeben Freek J. M. , Schenning Albertus P. H. J. , Meijer E. W. 
Published: November 2005

AbstractThe supramolecular structure of two types of oligo(p‐phenylene vinylene) (OPV) building blocks in dodecane solution is studied. Monofunctional chromophores (MOPV) form well‐defined helical assemblies, whereas bifunctional molecules (BOPV) aggregate into so‐called frustrated stacks, lacking any higher helical order. This difference in organization has a major influence on the transfer of excitation energy through the assemblies. Energy transfer to supramolecularly incorporated guests (MOPV with lower bandgap) is used to probe the intrinsic differences in exciton mobility in these two types of mixed aggregates. From the observed donor fluorescence quenching, it can be concluded that the helically ordered nature of the MOPV stacks facilitates the transfer of excitation energy, yielding evidence for higher exciton mobility in the well‐ordered assemblies than in the frustrated stacks. Finally, the concept of energy transfer in supramolecular assemblies is extended to the solid state by the successful implementation in a light‐emitting diode (LED).
Image Contrast Analysis of STM Images of Self‐Assembled Dioctadecyl Chalcogenides on Graphite at the Liquid–Solid Interface
Authors: Fukumura Hiroshi , I‐i Daizo , Uji‐i Hiroshi , Nishio Satoru , Sakai Hitoshi , Ohuchi Akihiko 
Published: November 2005

AbstractThe structures of self‐assembled monolayers of dioctadecyl selenide (CH3(CH2)17)2Se and dioctadecyl telluride (CH3(CH2)17)2Te, as well as dioctadecyl ether (CH3(CH2)17)2O and dioctadecyl sulfide (CH3(CH2)17)2S, on graphite at the liquid–solid interface were systematically investigated by scanning tunneling microscopy (STM). Both dioctadecyl selenide and telluride formed monolayer structures in which the tilt angle between the molecular axis of the alkyl chain and the lamellae axis was 90°, while dioctadecyl ether assembled with a tilt angle of 60°. Dioctadecyl sulfide was found to make two different self‐assembled structures having tilt angles of 60 and 90°. When selenide was embedded in ether compounds in mixed self‐assembled monolayers, the alkyl chains of the selenide became blurred, implying that the alkyl chains in the monolayers were unstable. This is in contrast with the structure of co‐adsorbed monolayers of the ether and sulfide compounds, where the images of all alkyl chains had high spatial resolution. For the co‐adsorbed monolayers, the image contrast of chalcogen atoms was normalized compared with that of alkyl chains of the ether compound in the same image frame. The normalized image contrast was found to be independent of the measurement conditions involving tip shapes, having the following trend, Te>Se>S>C>O. The difference in the normalized image contrast among chalcogen atoms are discussed based on fundamental parameters like polarizability and atomic radii.
The Trigonal Bipyramidal MN3M Species: A New Kind of Aromatic Complex Containing a Multiple‐Fold Aromatic N3 Subunit
Authors: Li Ying , Li Zhi‐Ru , Wu Di , Chen Wei , Sun Chia‐Chung 
Published: November 2005

AbstractA new kind of aromatic trigonal bipyramidal MN3M (M=Be, B, Mg, Al, and Ca) species, with all real frequencies, is obtained at the MP2/6‐311+G(3d) level. The nucleus‐independent chemical shift values are −102.16 ppm for the N33− ring, and −74.09, −79.39, −65.06, −74.44, and −62.33 ppm (at the geometrical center of the trigonal bipyramid) for BeN3Be, BN3B, MgN3Mg, AlN3Al, and CaN3Ca, respectively. Molecular orbital analysis indicates that the regular triangular N33− ring and each MN3M species have three aromatic six‐electron systems (π, σp, and σs) and exhibit threefold aromaticity. The CaN3Ca species has a very low vertical ionization energy of 3.64 eV at the CCSD(T)/6‐311+G(3d) level, which is even lower than the ionization energy (3.9 eV) of the Cs atom. Therefore, CaN3Ca can be considered as a new superalkali species. A further study on the CaN3CaCl molecule confirms the superalkali characteristics of CaN3Ca. Two interesting phenomena are explored in the MN3M species: the delocalized electron cloud of the N3 subunit is elongated by two M cations, and the electron clouds of two M cations are distended by the N33− ring.
Photophysical Properties of BODIPY‐Derived Hydroxyaryl Fluorescent pH Probes in Solution
Authors: Qin Wenwu , Baruah Mukulesh , Stefan Alina , Van der Auweraer Mark , Boens Noël 
Published: November 2005

AbstractThe photophysical properties of five fluorescent pH probes derived from 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene with phenolic or naphtholic subunits at position 8 and with substituents having different electron driving forces at positions 3 and 5 have been investigated in several organic solvents, by means of absorption, steady‐state, and time‐resolved fluorimetry. For each compound, the fluorescence quantum yield and lifetime are lower in solvents with higher polarity, owing to an increase in the rate of nonradiative deactivation. The rate constants for radiative deactivation, kf, are nearly constant for all dyes in all solvents studied [kf=(1.7±0.2)×108 s−1]. In aqueous solution, these probes undergo a reversible protonation–deprotonation in the near‐neutral to basic pH range, producing intensity increases with lower pH. The pKa values of the indicators are between 7.5 and 9.3, depending on the substitution pattern on positions 3, 5, and 8. The difference between the absorption and excitation spectra as a function of pH is indicative of the presence of two species in aqueous solution: the phenol‐ or naphthol‐based indicator and its conjugate base.
Energy Transfer by a Hopping Mechanism in Dinuclear IrIII/RuII Complexes: A Molecular Wire?
Authors: Welter Steve , Lafolet Frédéric , Cecchetto Elio , Vergeer Frank , De Cola Luisa 
Published: November 2005

AbstractThe synthesis and electrochemical and photophysical properties of a series of heterodinuclear ruthenium–iridium complexes linked by a modular para‐phenylene bridge [Ir–phn–Ru]3+ (Ir=Ir(ppyFF)2bpy, Ru=Ru(bpy)3, ppyFF=2‐(2,4‐difluorophenyl)pyridine), bpy=2,2′‐bipyridine, ph=phenylene, n=2, 3, 4, 5) are reported. The use of a high‐energy iridium complex, which can act as an energy donor when coupled to the lower energy ruthenium‐based component, allows the investigation of photoinduced energy transfer from the excited iridium‐centre to the ruthenium fragment (energy acceptor). The rate constants of the energy‐transfer processes are determined by time‐resolved emission and sub‐picosecond transient absorption spectroscopy. Interestingly, there is almost no decrease in transfer efficiency or rates as the length between the two chromophores (number of spacers) is increased. This “molecular wire” behavior indicates the dominance of the incoherent hopping mechanism, allowing a very fast energy transfer over long distances (with n=5 the metal‐to‐metal distance is estimated to be 32.5 Å). This is the first case in which such behavior is observed for metal complexes, and could lead to new development in molecular electronics.
Normal lymphocytes from leukemic samples as an internal quality control for fluorescence intensity in immunophenotyping of acute leukemias
Authors: Ratei Richard , Karawajew Leonid , Lacombe Francis , Jagoda Krystyna , Del Poeta Giovanni , Kraan Jaco , De Santiago Maria , Kappelmayer János , Björklund Elisabeth , Ludwig W.‐D. , Gratama Jan , Orfao Alberto 
Published: November 2005

AbstractBackgroundMultiparametric flow cytometry has become an indispensable but complex tool for the diagnosis of acute leukemias. Interpretation of immunophenotypic data within a six‐parameter analytical space relies on the standardization and validation of the instrument, the reagents, and the procedure. To address whether or not residual normal lymphocytes, usually present within leukemic samples, can serve as internal quality control for fluorescence intensity, 116 leukemic and 35 normal samples were analyzed.MethodsEight laboratories participated in the study and recruited a total of 151 individuals including 29 patients with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), 77 with acute myeloid leukemia (AML), 10 with T‐cell precursor acute lymphoblastic leukemia (T‐ALL), and 35 normal bone marrow donors. Lymphocytes were gated according to the CD45hi/SSClo gating strategy, after which median fluorescence intensities (MFI) as well as percentages of positive cells (%positive) for CD19, CD22, CD7, and CD3 were recorded. Nonparametric statistics were used to compare variation within and between laboratories.ResultsNormal lymphocytes within leukemic samples do not show substantial differences compared to lymphocytes from normal controls with respect to expression of CD19, CD22, CD7, and CD3. In particular, longitudinal control charts of MFI values for CD3 antigen provide useful information on analytical and instrument performance.ConclusionResidual normal lymphocytes can serve as internal quality control for studies addressing fluorescence intensity in the setting of immunophenotyping of acute leukemias. © 2005 Wiley‐Liss, Inc.
A perceptual quality model intended for adaptive VoIP applications
Authors: Hoene Christian , Karl Holger , Wolisz Adam 
Published: November 2005

AbstractQuality models predict the perceptual quality of services as they calculate subjective ratings from measured parameters. In this article, we present a new quality model that evaluates Voice over IP (VoIP) telephone calls. In addition to packet loss rate, coding mode and delay, it takes into account the impairments due to changes in the transmission configuration (e.g. switching the coding mode or re‐scheduling the playout time). Moreover, this model can be used at run time to control the transmission of such calls. It is also computationally efficient and open source.To demonstrate the potential of our model, we apply it to select the ideal coding and packet rate in bandwidth‐limited environments. Furthermore, we decide, based on model predictions, whether to delay the playout of speech frames afterdelay spikes. Delay spikes often occur after congestion and cause packets to arrive too late. We show a considerable improvement in perceptual speech quality if our model is applied to control VoIP transmissions. Copyright © 2005 John Wiley & Sons, Ltd.