bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capacity Building Strategy for Increasing Economic Productivity of Small and Medium Industries
Authors: Rahmad Rahmad , Yunimar Yunimar , Prawira Adi , Nasfi Nasfi 
Published: March 2024

Purpose – Research to determine the effect of increasing the Capacity of Small and Medium Industries (IKM) to increase the capacity and productivity of economic activities. Research in the city of Bukittinggi from July to October 2022.
Methodology/approach – Descriptive qualitative research methods, interview analysis techniques, group discussion forums and the Delpi technique. First, interview 6 SMI actors, second, 5 expert informants and three government stakeholders.
Findings – Research Findings The factors increasing IKM capacity are Capital, HR Quality, Facilities, Marketing, Production Quality, Financial Management, Technology, Promotion, Availability of Raw Materials and Environmental Support, the results of factors that greatly influence IKM capacity are HR Quality with a score of 5.00 or 100% with Very important criteria and results based on the Effectiveness Level of the government's response to the factor known that Capital has a high effectiveness of the government's response with a score of 4.20 or 84% with Effective criteria, while a low level of effectiveness of the government's response is Financial Management with a score of 2, 80 or 56% with Less Effective Criteria. Research results strategies, improving financial management, academic collaboration and information technology enhancement as well as increasing raw materials and government supervision.
The influence of Organizational Culture and Teamwork on Employee Engagement: Role of Achievement Motivation as a Mediation
Authors: Simbolon Novendi , Nurhayati Mafizatun 
Published: March 2024

This study aims to determine the influence of organizational culture, teamwork on employee engagement mediated by achievement motivation. The method used in this study is quantitative research. The population in this study is halo BCA employees who work for more than a year total 292 employees. The sampling technique using accidental sampling (convenience sampling) with the slovin formula was obtained by 168 respondents. Data analysis using SEM PLS (Partial Least Square) analysis technique. The results showed that organizational culture variables, achievement motivation had a positive and significant effect on employee engagement. Teamwork does not have a positive effect on employee engagement, and teamwork through mediation of achievement motivation has a positive and significant effect on employees, as well as mediated by achievement motivation, organizational culture and teamwork can strengthen the influence on employee engagement at halo BCA BSD.

Keywords: Organizational Culture, Teamwork, Achievement Motivation, Employee Engagement
In vivo inhibitory effect of Panicum maximum root extract on alpha amylase and alpha glucosidase enzymes of rats
Authors: Nwakaego Ebong 
Published: March 2024

Panicum maximum Jacq, (Poaceae) a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo. The leaf extract (137, 273, and 547 mg/kg) of Panicum maximum were investigated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The leaf extract non dose-dependently caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the leaf extract of Panicum maximum have the potentials to inhibit alpha amylase and glucosidase in rats.
Medicinal values of the genus Phyllanthus - A review
Authors: Unigwe Robinson , Okey Stephen Nnaemeka 
Published: March 2024

Phyllanthus species are known for their many medicinal values used in folklore medicine in many parts of the world. They have array of phytochemicals in the leaf, flower, seed, stem and root, that confer medicinal advantage on them. Extracts have shown a broad range of pharmacological activities like hepatoprotective, antioxidant, antiviral, antimicrobial, antidiabetic, anti-inflammatory, anticancer, antimalarial, nephroprotective, diuretic, and several other properties. This review highlighted different research results from other scientists in the past and present, all tailored towards exploring the inherent pharmacological properties of this herb for ethno-medicine, alternative medicine and pharmaceutical purposes.
Hepatoprotective activity of ethanol root extract and fractions of Hippocratea africana against doxorubicin-induced liver toxicity
Authors: Joseph Oyepata , Okokon Jude , Okokon Jude 
Published: March 2024

Doxorubicin (DOX) is an anthracycline glycoside antibiotic with high efficacy against various forms of cancer, whose clinical usefulness has been limited by associated undesirable organs toxicities such as cardiomyopathy, nephrotoxicity and hepatotoxicity despite its high therapeutic index. Hippocratea africana root used locally in the treatment of poisoning was evaluated for antidotal potentials against DOX-induced liver toxicity in rats. Hippocratea africana ethanol root extract as well as dichloromethane and aqueous fractions were evaluated for hepatoprotective activity against doxorubicin-induced liver injury in rats at various doses of the crude extract (200-600 mg/kg) and 400 mg/kg each of dichloromethane (DCM) and aqueous fractions respectively. Liver function parameters, liver oxidative stress markers and liver histology were used to assess the liver protective potential of the extract and fractions. The root extract and fractions significantly (p<0.05-0.01) reduced the serum levels of AST, ALT, ALP, total and direct bilirubin that were elevated by doxorubincin. Also, the levels of total protein and albumin reduced by doxorubicin were increased by the extract coadministration. The levels of GSH, GST, SOD, GPx, and CAT that were decreased by doxorubicin were significantly (p<0.01) elevated and raised MDA level was reduced by the leaf extract. Histology of the liver sections of extract -treated animals showed reductions in the pathological features compared to the DOX-treated animals. The observed histopathological changes were consistent with chemical pathological observations suggesting marked hepatoprotective potential. The anti-toxic effect of this plant may in part be mediated through the chemical constituents of the plant. The plant, Hippocratea africana possesses anti-toxicant properties which can be exploited in the treatment of doxorubicin related toxicities.
Preliminary physicochemical evaluation of effervescent granules of Anogiessius leocarpus stem bark extract
Authors: Olayemi Olubunmi , Morka Favour , Adesola Omoshallewa 
Published: March 2024

The plant Anogeissus leiocarpus is traditionally used in the treatment of ulcers including gastric ulcers. Effervescent granules are unique, pleasant-tasting oral formulations which are ingested as liquids. This study is a preliminary development and evaluation of effervescent granules of the aqueous extract of the stem bark of Anogeissus leiocarpus. The extract was obtained by drying the filtrate gotten from maceration of the dried, crushed stem bark in water. The acids (citric and tartaric acid) were each combined with the base (sodium bicarbonate) in 1:1 and 1:2 ratios and these were mixed with the extract using either the fusion or wet granulation method of preparation of effervescent granules. The granules were evaluated for their flow properties, moisture content, pH after dissolution, effervescent time and in vitro dissolution. Results show that granules prepared by the fusion method possessed better flow properties than those prepared by wet granulation. Moisture content of the granules was similar. Granules containing higher base content had higher pH (7.29 and 7.30) and faster effervescent time (86 -99 sec) than those containing equal ratio of acid and base with pH of 5.85 and 5.96 and effervescent time of 104 -150 sec. In vitro release was faster release from formulations containing higher base content (100 and 90.32 % respectively) than the other batches. Aqueous extract of the stem bark of Anogeissus leiocarpus can be suitably formulated into effervescent granules.
A Novel Approach on the Sensitivity of Preserved Plasmodium falciparum Positive RDT kits for the Molecular Detection of Pfmdr 1 and Pfcrt Genes in Pregnant Women
Authors: Abubakar Hafiz 
Published: March 2024

Storing blood samples for molecular screening have become increasingly difficult due to unstable electricity and high cost of generators fuels. Samples often deteriorate giving false negative upon molecular analysis. This research was aimed at determining the sensitivity of preserved Plasmodium falciparum positive RDT kits for the molecular detection of Pfmdr 1 and Pfcrt genes among pregnant women in From February 2020 to May 2020, Sokoto, Nigeria. 200 pregnant patients who visited the hospital for ANC had their blood samples taken, and a questionnaire was given out. To detect Plasmodium falciparum, RDT kits tailored to its monoclonal antibody were utilized. P. falciparum positive Rapid Diagnostic Test Kits were air tightened with nylon and silica-preserved for three months in a closed cabinet. The preserved positive samples were utilized to extract DNA, and the Pfmdr1 and Pfcrt genes' existence was then checked using a PCR procedure. 4 samples tested positive for both genes, suggesting a 21.05 % prevalence, according to the results of the inquiry into the Pfcrt and Pfmdr1 genes. This study has revealed the sensitivity of preserved RDT kits (with silica) for DNA extraction. Researchers and molecular laboratories should be preserving positive RDT kits meant for DNA extraction and other molecular analysis as it is much easier to preserve and there is no cost involved.
Extarction and charcterization of mucilage from Irvingia gabonensis seeds
Authors: Orugun Oluwaseun , Yahaya Paul , Tijani Mustapha , Yahaya Zwanden , Guga Mponan , Anyebe Sophie 
Published: March 2024

This study focuses on the extraction and characterization of mucilage from Irvingia gabonensis seeds and its potential uses. The extraction process was carried out using water and the mucilage was characterized using various physicochemical and rheological parameters. All confirmatory tests for mucilage carried out (Molisch, iodine and ruthenium red test) were positive. The outcomes demonstrated that the mucilage had a yield of 52.6 %, a swelling capacity of 88.65 %, hydration capacity of 1.78 and a viscosity of 1.1805 mPa S. This study highlights the importance of utilizing natural resources for sustainable development and provides insights for further research on the potential uses of mucilage from other plant sources.
Investigation Of Pro-fertility Actions Of “Female Corrective” Poly-herbal Medicine Formulation Using Female Wister Rat Model
Authors: Oraekei Daniel Ikechukwu , MBAGWU SONNE IKECHUKWU , Anaekwe Brendan Chinedu 
Published: March 2024

Plants contain numerous phytochemical compounds that may be used to cure or prevent diseases. In this study, the pro-fertility actions of “Female corrective” poly-herbal formulation were investigated using female Wister rat model. Phytochemicals, acute toxicities, body weight changes, and antioxidant and female reproductive hormonal studies were carried out. Serum levels of glutathione, superoxide dismutase and catalase were also evaluated. Micro well experiment was used to study the impact of the poly-herbal formulation on reproductive hormones. The phytochemical compounds present in the “Female corrective” were glycosides, saponins, tannins, flavonoids, steroids and terpenoids. In the median lethal dose estimation, no mortality nor obvious signs of toxicity were recorded at the dose of 88 mg/kg body weight. At a concentration of 4.4 mg/mL the body weights of the rats were increased in a dose dependent manner; 2.06, 4.11 and 8.22 mL/kg body weight gave changes in body weights of 17.13, 20.00 and 22.44% respectively after 14 days. Antioxidant effects were recorded as increase in serum concentration of glutathione, superoxide dismutase and catalase. Also, the serum levels of follicle stimulating hormone and luteinizing hormone were increased significantly (p ˂ 0.05) and dose dependently; at the same administered doses, serum levels of follicle stimulating hormone were 3.06 ± 0.06, 4.61 ± 0.05 and 5.25 ± 0.09 mIU/mL respectively and that of luteinizing hormone were 1.02 ± 0.10, 1.71 ± 0.23 and 2.08 ± 0.20 mIU/mL respectively. The possible mechanisms of the herbal drug formulation might include antioxidant as well as pro-gonadotropin activities
Antibacterial activity of five selected ethno-medicinal plants against extreme multi-drug resistance strains of pseudomonas aeruginosa and Staphylococcus aureus
Authors: Hassan Abba 
Published: March 2024

Emergence of multidrug resistance strains of different kinds of virulent pathogens to various antibiotics worldwide had become one of the most concerning public health issues in Nigeria. This research is aimed at evaluating the antibacterial activity of five selected ethno-medicinal plants against multi-drug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Ficus sycomorus, Vitex doniana, Jatropha curcas, Acacia nilotica and Prosopis africana leafs were extracted using chloroform, to get the crude extracts of the various plants material. Exactly 150 clinical and environmental samples each, was collected for the isolation of Pseudomonas aeruginosa and Staphylococcus aureus each. The antibiogram profile and resistance level of the isolated strains was ascertained using the standard disc diffusion bioassay. Multi-drug resistance genes; BLA-TEM, BLA-SHV and CTX-M presence were evaluated and also served as another form of selection protocol for extremely resistant strains of the selected pathogenic bacterial species. In-vitro and in-vivo bioassay was done to evaluate the antimicrobial potential of the plants extracts on the most resistant strains of the two pathogenic bacteria. Tannins, saponin, alkaloids, flavonoids, phenols, terpenoids, quinones, phytosterols and phlobatanins were found present in these plants extracts. Eleven Pseudomonas aeruginosa and four Staphylococcus aureus extreme multi-drug resistance strains were successfully isolated and identified. The in-vitro bioassay reveals that F. sycomorus and J. curcas extracts has the highest antimicrobial activity against the various multi-drug resistant strains, while A. nilotica extract also maintains some level of activity against the resistant strains. The in-vivo bioassay reconfirmed the antibacterial effects of the three most active plants mentioned above, against all the resistant bacteria. Decoction of the three most active plants extracts also proves effective on the resistant strains of both bacteria, than the individual extracts. F. sycomorus, J. curcas and A. nilotica plant extracts could provide an alternative active pharmaceutical agents against multidrug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus.
Prevalence of hospital acquired gastrointestinal protozoa parasites among in-patients of a missionary and private hospital in Awka, Southeastern Nigeria
Authors: Ishar Cornelius Orjighjigh , Ikeh Mulumba Ifeanyi , Benedict Aboje Godwin , Okeke Obiageli Anthonia , Aghalu Uchenna Chinonye , Offor Vivian , Nnatuanya Ifebunandu Okwudilichukwu 
Published: March 2024

Regardless of the efforts by health organizations and hospital personnel, research continues to report hospital acquired infections in admitted patients worldwide. This research was carried out to survey the prevalence of hospital acquired gastrointestinal protozoa parasites among admitted patients of Regina Caeli Specialist Hospital (missionary hospital) and Izunna Hospital and Maternity (private hospital) in Awka South LGA of Anambra State, Southeast Nigeria. Two samples each from 79 patients were collected and analyzed using direct wet mount and formol ether concentration technique. Other information concerning demography and risk factors were obtained with the aid of a structured questionnaire. Data obtained was analyzed using chi-square test and probability values ≤ 0.05 were considered significant. Out of the samples examined, 9(11.4%) were positive for hospital acquired gastrointestinal protozoa parasites. Hospital acquired gastrointestinal protozoa parasites were found to occur in all two hospitals with the missionary hospital having the highest occurrence rate of 66.7%. Males recorded the highest prevalence of 6(15.8%) compared to females 3(7.3%) while age group 50-59years had the highest prevalence of 28.6%. Patients from the male ward recorded a higher prevalence of 17.9%. Meanwhile patients whose occupation is farming had a higher prevalence of 25.0% while patients who only wash their vegetables/fruits sometimes before eating presented a higher prevalence of 18.2%. Prevalence of hospital acquired gastrointestinal protozoa parasite infection was strongly associated with duration of hospital stay (P˂ 0.000). Out of the four parasites identified, Entamoeba histolytica was the most prevalent with 5(55.6%). Consequently, regulation of patients’ hospital stay, sanitation and better hygiene practices should be adopted and encouraged to prevent the spread of hospital acquired infection.
Antipyretic and Antinociceptive Effect of the Methanol Leaf Extract of Ficus asperifolia in Murine Models
Authors: Doma Ibrahim , Haruna Ibrahim , Hamza Abdullahi 
Published: March 2024

Pyrexia occurs as a result of the resetting of the hypothalamic set-point. Non steroidal anti-inflammatory drugs used for the treatment of fever and related illnesses are associated with side effects including gastrointestinal irritation, bleeding, ulcers and perforation. In traditional medicine, many plants have been found to possess antipyretic activity. Ficus asperifolia (Miq), family Moraceae has been traditionally used to treat pain and fevers. The aim of the study was thus to evaluate the antipyretic and antinociceptive activity of the methanol leaf extract of Ficus asperifolia (FME) in murine models. Preliminary phytochemical screening and oral acute toxicity studies were conducted using standard protocols. Antipyretic activity was evaluated using the Brewer’s yeast induced pyrexia model. Antinociceptive effects were investigated using the acetic acid and thermal induced models. The mechanism of action of the plant was also evaluated against several antagonists. FME significantly (p<0.05) and dose dependently reduced yeast induced pyrexia. FME at doses 125, 250 and 500 mg/kg significantly (p<0.05) decreased acetic acid induced abdominal writhes and increased the mean reaction time of mice to thermal-induced pain stimulus. Pre-treatment of mice with naloxone (a non-selective opioid receptor antagonist), glibenclamide (a potassium channel blocker) and L-NNA (a nitric oxide synthase inhibitor) significantly reversed the analgesic action of the extract suggesting that the activity is likely mediated via the involvement of these pathways.
ANALISIS FITUR DAN MANFAAT APLIKASI NETSUPPORT SCHOOL PADA PEMBELAJARAN INFORMATIKA DI LABORATORIUM KOMPUTER
Authors: AL WAAIDHOH NUZHAH 
Published: March 2024

Pembelajaran Informatika di SMP Negeri 5 Salatiga dilaksanakan melalui mode plugged dengan menggunakan komputer yang berada di laboratorium komputer. Untuk mengelola pembelajaran serta perangkat komputer yang ada di laboratorium, diperlukan suatu teknologi atau aplikasi. Salah satu aplikasi yang dapat digunakan untuk mempermudah manajemen laboratorium komputer yaitu NetSupport School yang memanfaatkan teknologi jaringan komputer LAN (Local Area Network). Penelitian ini menggunakan metode pendekatan deskriptif kualitatif untuk mengumpulkan dan menganalisis data tentang pemanfaatan suatu aplikasi, dengan teknik pengumpulan data melalui penjabaran fitur-fitur yang ada pada aplikasi NetSupport School, penjelasan bagaimana aplikasi NetSupport School dapat digunakan dalam manajemen pembelajaran di laboratorium komputer, serta analisis manfaat aplikasi NetSupport School dalam pembelajaran di laboratorium komputer. Hasil yang diperoleh yaitu aplikasi NetSupport School memiliki banyak manfaat saat diimplementasikan dalam pembelajaran di laboratorium komputer, diantaranya mempermudah guru dalam memantau aktivitas siswa di komputer client, mengelola pembelajaran dengan menampilkan presentasi materi di layar komputer client, mengirim dan mendistribusikan file ke seluruh komputer client, mengatur aplikasi dan website apa saja yang dapat diakses oleh siswa serta aplikasi dan website apa saja yang diblokir, menyalakan (power on) dan mematikan (shutdown) seluruh komputer client dari komputer server, serta perawatan seluruh perangkat komputer yang ada di laboratorium komputer.

Kata kunci : NetSupport School, Pembelajaran Informatika, Laboratorium Komputer, LAN, Client Server.
Integrasi Kurikulum Pondok Pesantren dan Madrasah Aliyah pada Mata Pelajaran Rumpun Pendidikan Agama Islam di Alwasilah Lilhasanah Islamic Boarding School
Authors: Marwiji Muh. Hasan , Wahyudin Wahyudin , Setiono Joko , Qomaruzzaman Bambang , Zaqiah Qiqi Yuliati 
Published: March 2024

Penelitian ini bertujuan menganalisis integrasi kurikulum pondok pesantren dan madrasah aliyah di Alwasilah lilhasanah Islamic boarding school. diharapkan dapat memberikan kontribusi penting dalam pengembangan pendidikan agama Islam yang holistik dan relevan dengan kebutuhan peserta didik di era kontemporer. Penelitian menggunakan pendekatan kualitatif agar mampu menemukan dan menganalisi deskripsi mengani objek yang sednag diteliti. Adapun hasil penelitian menunjukan bahwa integrasi kurikulum tersebut dilakukan yaitu melalui mata pelajaran yang di integrasikan secara konten antara di pondok pesantren dan di Madrasah aliyah misalnya pembelajaran di Madrasah itu menggunakan kitab kuning tidak lagi menggunakan buku paket dari kementerian namun secara konten tetap mengambil dari kurikulum madrasah. Selain itu juga kegiatan 24 jam semuanya terintegrasi antara madrasah dan pondok pesantren, kemudian melalui kegiatan ekstrakurikuler muhadoroh, debat agama, dan kegiatan sains. selanjiutnya melalui pelajaran umum seperti bahasa arab dibantu dengan belajar metode baca kitab kuning amstilati, begitu juga bahasa inggris tidak hanya dipelajari di madrasah, tetapi dipelajari dan dipraktekan juga di pondok pesantren.
Trend analysis and change-point detection of monsoon rainfall in Uttarakhand and its impact on vegetation productivity
Authors: SWAMI PRIYANKA 
Published: March 2024

This study analyzes the long-term spatio-temporal changes and trend analysis in rainfall using the data from 1901 to 2020 and its impact on vegetation from 2000 to 2020 across districts of Uttarakhand. The Pettitt test was employed to detect the abrupt change point in time frame, while the Mann-Kendall (MK) test was performed to analyze the rainfall trend. Results show that the most of the districts exhibited significant negative trend of rainfall in monsoon, except two districts. Out of 13 districts, 4 districts recorded noteworthy rainfall declining trend for the monsoon season at 0.05% significance level, while the insignificant negative trend of rainfall was detected for 7 districts of Uttarakhand. Furthermore, the significant negative trend (-2.23) was recorded for overall monsoon rainfall of Uttarakhand. Based on the findings of change detection, the most probable year of change detection was occurred primarily after 1960 for most of the districts of Uttarakhand. A significant decline rainfall was detected after 1960 while after 1970 interannual variability of rainfall was recorded to be increased. The analysis of month wise cumulative gross primary productivity (GPP) for 13 districts with rainfall trends shows that there is significant impact of rainfall trend on GPP during month of June and it gradually reduces for subsequent monsoon months. It was observed that the GPP of region is increasing at rate of 9.1 gCm-2d-1 in the region since 2000. Based on sensitivity analysis, the GPP of cropped area of region is more sensitive towards rainfall than forest area of Uttarakhand.