bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the efficacy and safety of a new recombinant human follicle‐stimulating hormone (DA‐3801) with follitropin‐α (Gonal‐F®) in women undergoing controlled ovarian hyperstimulation for assisted reproductive technology
Authors: Moon Shin Yong , Choi Young Sik , Ku Seung‐Yup , Kim Seok Hyun , Choi Young Min , Kang Inn Soo , Kim Chung Hoon 
Published: June 2007

AbstractAim:  To compare the efficacy and safety of a new recombinant human follicle‐stimulating hormone (FSH; DA‐3801) with follitropin‐α (Gonal‐F®) in women undergoing controlled ovarian hyperstimulation (COH) for assisted reproductive technology (ART).Methods:  This was a phase III, multicenter, randomized, non‐inferiority study. A total of 97 women were randomized to receive COH using DA‐3801 (DA‐3801 group, n = 49) or Gonal‐F® (Gonal‐F group, n = 48). All subjects underwent COH using a gonadotropin‐releasing hormone (GnRH) antagonist protocol. The primary efficacy endpoint was the number of oocytes retrieved, and the secondary efficacy endpoints included the total dose of FSH, the duration of stimulation, the serum estradiol levels on the day of human chorionic gonadotropin (hCG) administration, and the fertilization, implantation and pregnancy rates. Safety was evaluated using pre‐ and post‐treatment laboratory tests and all adverse events were recorded.Results:  The number of oocytes retrieved was 13.0 ± 6.2 (DA‐3801) versus 10.6 ± 6.7 (Gonal‐F) in the intention‐to‐treat (ITT) population, and 12.7 ± 6.4 (DA‐3801) versus 11.0 ± 7.1 (Gonal‐F) in the per‐protocol (PP) population. The non‐inferiority of DA‐3801 was demonstrated with differences of 2.3 ± 6.5 (95% confidence interval [CI] = 0.13, ∞) and 1.7 ± 6.7 (95% CI = −0.74, ∞), respectively, in the ITT and PP populations. The total dose of FSH used (1789.8 ± 465.5 vs 2055.6 ± 646.7 pg/mL, P = 0.027) and duration of stimulation (8.3 ± 1.4 vs 9.1 ± 1.9 days, P = 0.036) in the ITT population were significantly lower in the DA‐3801 group. Other secondary efficacy endpoints, including pregnancy and implantation rates and the incidence and severity of adverse events, were comparable between the two groups.Conclusions:  The results of this study demonstrate that DA‐3801 is not inferior to follitropin‐α in terms of its efficacy and safety in women undergoing COH for ART.
Kampo therapy for premenstrual syndrome: Efficacy of Kamishoyosan quantified using the second derivative of the fingertip photoplethysmogram
Authors: Kimura Yoko , Takamatsu Kiyoshi , Fujii Asami , Suzuki Mayumi , Chikada Naoko , Tanada Rie , Kume Yumi , Sato Hiroshi 
Published: June 2007

AbstractAim:  Premenstrual syndrome (PMS) affects 40–80% of women. Japanese herbal medicine, known as Kampo, is frequently prescribed for PMS, so we examined the efficacy of Kamishoyosan using two methods: first, the second derivative of the fingertip photoplethysmogram (SDPTG) evaluating vascular age (VA), and second, a self‐assessment questionnaire on subjective symptoms.Methods:  The SDPTG was recorded in 45 patients with PMS (mean ± SD = 32 ± 6 years of age) before (0 M), on the first (1 M) and third (3 M) month of therapy. Patients answered a questionnaire (44 questions) on their complaints every month. The reproducibility of the SDPTG was confirmed with 15 normal volunteers (33 ± 9 years of age).Results:  In patients with older VA than their chronological age (Age) before therapy, we found linear correlations of the VA–Age differences at 1 M versus 0 M (y = 0.45x + 1.59, standard error of estimate [SEE] = 6.13 years), and at 3 M versus 0 M (y = 0.18x + 4.09, SEE = 6.03 years). The VA–Age decreased from 11.3 ± 6.4 (0 M) to 6.6 ± 6.7 (1 M) and 6.1 ± 6.0 years (3 M) (P < 0.01). The score on the self‐assessment questionnaires for the five most frequent symptoms significantly improved from 13.4 ± 3.3 (0 M) of 20 to 10.7 ± 3.9 (1 M) and 8.2 ± 4.6 (3 M) (P < 0.01).Conclusion:  The improvement of PMS symptoms as a result of using Kamishoyosan was quantified by means of SDPTG and the self‐assessment questionnaire.
Comparison of the use of electrothermal bipolar vessel sealer with harmonic scalpel in total laparoscopic hysterectomy
Authors: Demirturk Fazli , Aytan Hakan , Caliskan Ahmet C. 
Published: June 2007

AbstractAim:  The aim of the present study was to compare the use of electrothermal bipolar vessel sealer (EBVS) with harmonic scalpel (HS) during total laparoscopic hysterectomy with respect to operation time, estimated blood loss and related complications.Methods:  A retrospective study was conducted in the university hospital. Forty patients who underwent total laparoscopic hysterectomy and bilateral salpingo‐oophorectomy were enrolled. Nineteen hysterectomies were performed with HS and in 21 patients the same surgeons used EBVS. Data about the characteristics of the patients, operation time, estimated blood loss, uterine weights, related complications and length of hospital stay were registered and compared.Results:  Mean procedure time and estimated blood loss were significantly less in the EBVS arm (59.57 ± 3.71 vs 90.95 ± 5.73 min, P < 0.001; 87.76 ± 25.48 vs 152.63 ± 60.90 mL; P < 0.001, respectively). The change in hemoglobin and hematocrit values was found to be more significant in the HS group.Conclusion:  EBVS was found to be less time‐consuming and caused less bleeding when compared with HS.
Do different delivery systems of estrogen therapy influence serum lipids differently in surgically menopausal women?
Authors: Baksu Başak , Davas Inci , Agar Eser , Akyol Atıf , Uluocak Aygul 
Published: June 2007

AbstractAim:  To compare the influence of different delivery forms of estrogen therapy (ET) on serum lipid levels.Methods:  For this prospective, randomized, controlled study, 132 surgically menopausal women were assigned to 12 months of therapy with oral conjugated estrogen 0.625 mg/day (n = 35), intranasal 300 μg/day estradiol hemihydrate (n = 33), percutaneous gel 1.5 mg/day estradiol hemihydrate (n = 32) or no treatment (control group, n = 32). Total cholesterol (t‐Chol), triglycerides, high‐, low‐, and very low‐density lipoprotein (HDL‐Chol, LDL‐Chol, and VLDL‐Chol, respectively) levels were determined at baseline, and cycles 6 and 12. Data were analyzed using repeated measures ANOVA.Results:  All delivery forms significantly decreased t‐Chol and LDL‐Chol while increasing HDL‐Chol after 6 and 12 cycles. The oral route significantly increased whereas other modalities significantly decreased serum triglycerides after cycle 6 and 12. VLDL‐Chol levels were significantly increased using the oral route after cycle 12 while intranasal and percutaneous gel forms decreased the level after cycles 6 and 12.Conclusion:  Oral, intranasal and transdermal gel delivery modes of ET have beneficial effects on serum lipids, as shown by decreased t‐Chol and LDL‐Chol, and increased HDL‐Chol levels in surgically menopausal women. The oral form should be used with care in women with hypertriglyceridemia and with increased VLDL‐Chol levels. However, the oral route seems to be more effective in decreasing LDL‐Chol levels than the percutaneous gel form.
Women's douching practices and related attitudes in eastern Turkey
Authors: Ege Emel , Timur Sermin , Zincir Handan , Egri Mucahit , Sunar Reeder Bulbin 
Published: June 2007

AbstractAim:  Vaginal douching is a common hygiene practice for many women all over the world, but it is associated with several health risks. Little is known about the beliefs and attitudes that promote and maintain douching practices. Therefore, the objective of the present study was to evaluate the status of vaginal douching practices of women in the Malatya province of eastern Turkey.Methods:  This was a cross‐sectional study. A sample of 465 Muslim women was interviewed to ascertain the status of vaginal douching practices. All participants were between 15 and 49 years of age and all were married. Data were collected by using a questionnaire in the process of conducting face‐to‐face interviews in June 2004. Data analysis included descriptive statistics and logistic regression modeling.Results:  The present study revealed that the frequency of douching was 61.5% among women. The participants were frequently douching for feminine hygiene (47.6%). Vaginal douching practices were associated with several factors including education level (odds ratio [OR] = 1.991, 95% confidence interval [CI] = 1.154–3.434), family income (OR = 0.996, 95% CI = 0.994–0.998), marital age (OR = 0.402, 95% CI = 0.223–0.715), frequency of sexual intercourse (OR = 2.335, 95% CI = 1.532–3.554), and presence of genital syndromes/infections (OR = 1.813, 95% CI = 1.215–2.739).Conclusion:  This study provides preliminary information about women's douching practices and attitudes in the Malatya region of Turkey. It may also provide information to health‐care practitioners in their efforts to educate women on the adverse effects of vaginal douching.
Severe secondary postpartum hemorrhage 3 weeks after cesarean section: Alternative etiologies of uterine scar non‐union
Authors: Pollio Fabrizio , Staibano Stefania , De Falco Marianna , Buonocore Ugo , De Rosa Gaetano , Di Lieto Andrea 
Published: June 2007

AbstractA case of secondary postpartum hemorrhage that occurred 3 weeks after cesarean section requiring total abdominal hysterectomy is reported. The patient's history and pathologic features of the removed uterus did not allow the authors to clearly recognize a previous reported cause of this potentially life‐threatening complication. Alternative causes of the non‐union of the uterine incision are suggested.
Polypoid endocervical adenomyoma: A case report with clinicopathologic analyses
Authors: Ota Shunichiro , Ushijima Kimio , Nishio Shin , Fujiyoshi Naoki , Takemoto Shuji , Terada Atsumu , Kamura Toshiharu 
Published: June 2007

AbstractA case of polypoid endocervical adenomyoma (PEA) in the uterine cervix was encountered in the uterine cervix of a 56‐year‐old woman. Grossly, a well‐circumscribed polypoid tumor was observed protruding from the uterine cervix. Based on the findings of imaging studies, it was assumed to be an adenoma malignum in the uterine cervix. The tumor was composed of a mixture of proliferating glands of endocervical type and fascicles of smooth muscle. No distinct nuclear anaplasia, architectural abnormality or any evidence of destructive stromal invasion was observed. Adenoma malignum, which shows a gastric phenotype with immunoreactivity for HIK‐1083, was a serious diagnostic possibility. In the present case, the tumor was a well‐circumscribed polypoid lesion, with no cytologic or architectural abnormality; however, focal immunoreactivity was shown for HIK‐1083, which thus suggested it to be PEA. Therefore, the results of these ancillary diagnostic modalities should be interpreted with caution and combined with the gross and light microscopy findings.
Ectopic ovary: A case of autoamputated ovary with mature cystic teratoma into the cul‐de‐sac
Authors: Kusaka Masumi , Mikuni Masato 
Published: June 2007

AbstractAn ovary with a mature cystic teratoma which was autoamputated into the cul‐de‐sac and confirmed by laparoscopy is described. A 24‐year‐old woman with a history of chronic pelvic pain for 5 years presented with left abdominal pain. Magnetic resonance imaging revealed a left ovarian mass of 5 cm in diameter. The pain was relieved spontaneously after a few weeks. Laparoscopy was performed 5 months later. The mass was identified in the cul‐de‐sac partly enveloped in the omentum without any ligamentous or direct connection with the pelvic organs. There was no left ovary in its proper anatomical location. Histopathologic study revealed a mature cystic teratoma with viable ovarian tissue. These findings suggested autoamputation of the ovary either by inflammation or torsion, which is one of the mechanisms for the formation of an ectopic ovary.
Schwannoma in the retroperitoneum
Authors: Song Jae Yen , Kim Sue Yeon , Park Eun Gyung , Kim Chan Joo , Kim Do Gang , Lee Hye Kyung , Park In Yang 
Published: June 2007

AbstractSchwannoma (neurilemmoma) is a peripheral nerve sheath tumor and commonly occurs singularly on the head, neck, and trunk. Giant schwannoma is rarely located on the retroperitoneum and pelvic cavity. The majority of symptoms caused by the tumor are due to the effect of its mass. Surgical resection is enough to treat the tumor. Schwannoma is reported usually as benign, and despite incomplete resection of the tumor, the risk of recurrence and metastasis is low. A schwannoma on the retroperitoneum that was preoperatively misdiagnosed as a malignant adnexal mass in a 60‐year‐old menopausal woman is presented, with a brief review of the literature.
Corpus luteum hemorrhage: Rare complication of congenital and acquired coagulation abnormalities
Authors: Gupta Nupur , Dadhwal Vatsla , Deka Deepika , Jain Sunesh Kumar , Mittal Suneeta 
Published: June 2007

AbstractWomen taking anticoagulants or those with a clotting factor deficiency are at increased risk of corpus luteum rupture due to coagulation abnormalities and three such cases are described here. Case 1 was a 35‐year‐old woman with prosthetic mitral valve replacement who was on anticoagulant therapy, in whom hemoperitoneum secondary to ruptured corpus luteum was seen. Emergency laparotomy revealed 1.2 L of massive hemoperitoneum. Left salpingo‐oophorectomy was performed. Case 2 was two episodes of hemoperitoneum from luteal cyst rupture in a young patient with the rare congenital factor X deficiency. This patient was managed conservatively with fresh frozen plasma and blood transfusion. This is the first case of congenital factor X deficiency manifested as luteal rupture to be managed conservatively. Case 3 was two episodes of hemoperitoneum from luteal cyst rupture in a patient with antiphospholipid antibody syndrome who was on oral anticoagulants. Laparotomy was done twice with left salpingo‐oophorectomy in the first instance and partial excision of the right ovary in the second instance. Hemoperitoneum secondary to rupture of the corpus luteum should be considered in the differential diagnosis of acute abdominal pain in women with congenital and acquired coagulation deficiencies.
Endometrioid adenocarcinoma with a functioning stroma
Authors: Hayasaka Tadashi , Nakahara Kenji , Kojimahara Takanobu , Saito‐Sekiguchi Maki , Motoyama Teiichi , Kurachi Hirohisa 
Published: June 2007

AbstractA case of a 70‐year‐old woman with endometrioid adenocarcinoma of the ovary with functioning stroma is presented. The symptom was postmenopausal bleeding. The preoperative level of serum estradiol was as high as 162.4 pg/mL, and serum gonadotropin levels were suppressed. The endometrial tissue showed hyperplastic changes. The surgical specimens consisted of a multilocular cystic ovarian tumor of 95 mm in diameter and an enlarged uterus. Histologically, the tumor was composed of proliferating, atypical, columnar cancer cells resembling early secretory endometrial cells, and condensation of plumed stromal cells resembling theca lutein cells. The diagnosis of endometrial adenocarcinoma of the ovary with functioning stroma was made. After surgery, the serum levels of estradiol decreased and of follicle‐stimulating hormone increased. Almost all types of ovarian tumor have been reported to be associated with endocrine abnormalities. Mucinous epithelial ovarian tumors most commonly present with estrogenic stroma, although the frequency of endometrioid adenocarcinoma with functioning stroma is very low. Here, a rare case with the patient's clinical course and histopathologic findings is reported.
Isolated adenomyotic cyst associated with severe dysmenorrhea
Authors: Kamio Masaki , Taguchi Shuuhei , Oki Toshimichi , Tsuji Takahiro , Iwamoto Ichiro , Yoshinaga Mitsuhiro , Douchi Tsutomu 
Published: June 2007

AbstractA case of a 23‐year‐old, nulliparous female with a very rare isolated adenomyotic cyst inducing severe dysmenorrhea was seen. Transvaginal ultrasonographic tomography and magnetic resonance imaging (MRI) showed a 3 × 3‐cm cystic mass within the left anterior wall of the uterine corpus. The cystic space was filled with hyperintense fluid on T1‐weighted images, which was surrounded by hypointense tissue beside the right uterine corpus on T2‐weighted images. The case was preliminarily diagnosed using MRI as having cavitated rudimentary uterine horn. However, hysterosalpingography excluded the possibility of uterine anomaly. A hemorrhagic adenomyotic cyst measuring 3 cm within the left anterior wall of the uterine corpus was surgically removed. There was no evidence of diffuse adenomyosis uteri. Dysmenorrhea completely disappeared postoperatively.
Epithelioid trophoblastic tumor of the lung
Authors: Urabe Satoshi , Fujiwara Hisaya , Miyoshi Hiroshi , Arihiro Koji , Soma Hiroaki , Yoshihama Isao , Mineo Shoichiro , Kudo Yoshiki 
Published: June 2007

AbstractEpithelioid trophoblastic tumor (ETT) is a rare type of gestational trophoblastic disease and only 25 cases have been reported so far. It was first proposed by Mazur and Kurman in 1994 as an unusual type of trophoblastic tumor that is distinct from placental site trophoblastic tumor and choriocarcinoma and has features resembling carcinoma. A case of ETT of the lung in a 38‐year‐old Japanese woman is reported. The patient had suffered from a hydatidiform mole at the age of 27 years, and had four normal deliveries at the ages of 24, 31, 35 and 37 years. Because no tumor lesions were detected in the uterus, the patient was suspected of having metastatic choriocarcinoma with multiple lesions in the lung accompanied by an elevated level of human chorionic gonadotropin (hCG). In order to make an exact diagnosis, a partial resection of metastatic foci in the lung was performed. Microscopically, the tumor showed hemorrhagic necrotic foci and was composed of mainly mononuclear tumor cells and some giant tumor cells resembling trophoblastic cells. Immunohistochemical examination showed that a few large cells were stained positively for hCG, and that other cells were positive for human placental lactogen, pregnancy‐specific β1‐glycoprotein, cytokeratin 7 and inhibin‐α. In the ultrastructure, the tumor cells contained large nuclei and rich organella with desmosomes and well‐formed filaments. The diagnosis of ETT was confirmed from the findings as described above.
A novel formulation of the theory of critical distances to estimate lifetime of notched components in the medium‐cycle fatigue regime
Authors: SUSMEL L. , TAYLOR D. 
Published: June 2007

ABSTRACTIn the present paper, the theory of critical distances (TCD) is reformulated in order to make it suitable for predicting fatigue lifetime of notched components in the medium‐cycle fatigue regime. This extension of the TCD takes as its starting point the idea that the material characteristic length, L, changes as the number of cycles to failure, Nf, changes. In order to define the L versus Nf relationship two different strategies were investigated. Initially, we attempted to determine it by using the L values calculated considering material properties defined at the two extremes, namely static failure and the fatigue limit. This strategy, though correct from a philosophical point of view, contained some problems in its practical application. We subsequently attempted to determine the L versus Nf relationship by means of two calibration fatigue curves; (one generated by testing plain specimens and the second one generated by testing notched specimens). This second strategy was found to be much more simple to apply to practical problems, resulting in estimations characterized by a higher accuracy. The reliability of the devised method was systematically checked by using experimental results generated by testing notched specimens of low‐carbon steel containing different geometrical features and tested using various loading types, stress ratios and specimen thicknesses. The accuracy of the method was further verified by using several data sets taken from the literature. Our method was seen to be successful giving predictions falling always within the scatter band of the data from the parent material. These results are very interesting, especially considering that the TCD is very easy to use because it requires only a linear‐elastic stress analysis.
Crack closure in fibre metal laminates
Authors: PLOKKER H.M. , ALDERLIESTEN R.C. , BENEDICTUS R. 
Published: June 2007

ABSTRACTGLARE is a fibre metal laminate (FML) built up of alternating layers of S2‐glass/FM94 prepreg and aluminium 2024‐T3. The excellent fatigue behaviour of GLARE can be described with a recently published analytical prediction model.This model is based on linear elastic fracture mechanics and the assumption that a similar stress state in the aluminium layers of GLARE and monolithic aluminium result in the same crack growth behaviour. It therefore describes the crack growth with an effective stress intensity factor (SIF) range at the crack tip in the aluminium layers, including the effect of internal residual stress as result of curing and the stiffness differences between the individual layers. In that model, an empirical relation is used to calculate the effective SIF range, which had been determined without sufficiently investigating the effect of crack closure.This paper presents the research performed on crack closure in GLARE. It is assumed that crack closure in FMLs is determined by the actual stress cycles in the metal layers and that it can be described with the available relations for monolithic aluminium published in the literature.Fatigue crack growth experiments have been performed on GLARE specimens in which crack growth rates and crack opening stresses have been recorded. The prediction model incorporating the crack closure relation for aluminium 2024‐T3 obtained from the literature has been validated with the test results.It is concluded that crack growth in GLARE can be correlated with the effective SIF range at the crack tip in the aluminium layers, if it is determined with the crack closure relation for aluminium 2024‐T3 based on actual stresses in the aluminium layers.
Stress intensity factors for surface fatigue crack in a round bar under cyclic axial loading
Authors: YANG F. P. , KUANG Z. B. 
Published: June 2007

ABSTRACTIn this paper, the surface fatigue crack growth shape for an initial straight‐fronted edge crack in an elastic bar of circular cross‐section is determined through experiments under pure fatigue axial loading. Three different initial notch depths are discussed. The relations of the aspect ratio (b/c) and relative crack depth (b/D) are obtained, and it is shown that there is a great difference in the growth of cracks with different initial front shapes and crack depths. Further, using the three‐dimensional finite element method, the stress intensity factors (SIFs) are determined under remote uniform tension loading. Since the relationship of b/c and b/D changes during the fatigue crack growth, the SIFs are determined for different surface crack configurations.