bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Detection of Diabetic Peripheral Neuropathy in Diabetic Patients: A Cross-Sectional Study
Authors: Amelia Rina , Wahyuni Arlinda Sari , Yunanda Yuki , Fujiati Isti Ilmiati , Harahap Juliandi , Wijaya Hendri , Zulham Zulham , Saktioto Saktioto 
Published: April 2024

Background:
Diabetic Peripheral Neuropathy (DPN) is a chronic complication in
Type 2 Diabetes Mellitus (T2DM) patients and is characterized by paresthesia, pain, and hypoesthesia
of the extremities. The Diabetic Neuropathy Symptom-Score (DNS) is a quick, inexpensive,
and easy-to-perform tool to detect DPN in clinical practice. Biochemical markers like
Nitric Oxide (NO) and Vascular Endothelial Growth Factor (VEGF) play a role in the early detection
of DPN. This study aims to investigate the relationship between risk factors and these
biomarkers. So, it is expected to improve the prevention and treatment of diabetic neuropathy
more effectively.

Method:
A cross-sectional method was used for this study. The sample size was 85 patients
with T2DM who visited several primary healthcare in Medan, selected by consecutive sampling
method based on eligibility criteria. Data collected included DNS, assessment of NO, VEGF,
Glycated Hemoglobin (HbA1C), plasma blood glucose (PBG), and lipid profile. The collected
data were analyzed using an independent T-test.

Result:
The results showed that most T2DM patients, namely 73 people (85.9%), experienced
DPN. From the bivariate analysis results, the risk factors associated with the prevalence of
DPN in T2DM patients were found to be increased levels of total cholesterol, HbA1c, NO, and
VEGF (p < 0.05). Meanwhile, blood pressure, fasting BGL, HDL-C, LDL-C, and triglycerides
were not related to the occurrence of DPN in this study (p> 0.05).

Conclusion:
DNS can be used as a quick and easy initial screening tool implemented in clinical
practice for screening DPN. Diabetic patients with DPN tend to have lower NO and increased
VEGF; besides, NO levels are also associated with the progression of DPN. Furthermore, education,
blood sugar control, and physical exercise, especially leg exercises, can prevent progressive
DPN.
Research on the Mechanism of Traditional Chinese Medicine Treatment for Diseases caused by Human Coronavirus COVID-19
Authors: Wang Xian-Fang , Ma Chong-Yang , Du Zhi-Yong , Liu Yi-Feng , Ma Shao-Hui , Yu Sang , Jin Rui-xia , Wei Dong-Qing 
Published: April 2024

Background:
Human coronaviruses are a large group of viruses that exist widely in nature
and multiply through self-replication. Due to its suddenness and variability, it poses a great
threat to global human health and is a major problem currently faced by the medical and health
fields.

Objective:
COVID-19 is the seventh known coronavirus that can infect humans. The main purpose
of this paper is to analyze the effective components and action targets of the Longyi Zhengqi formula
and Lianhua Qingwen formula, study their mechanism of action in the treatment of new coronavirus
pneumonia (new coronavirus pneumonia), compare the similarities and differences of their
pharmacological effects, and obtain the pharmacodynamic mechanism of the two traditional Chinese
medicine compounds.

Methods:
Obtain the effective ingredients and targets of Longyi-Zhengqi Formula and Lianhua-
Qingwen Formula from ETCM (Encyclopedia of Traditional Chinese Medicine) and other traditional
Chinese medicine databases, use GeneCards database to obtain the relevant targets of COVID-19,
and use Cytoscape software to build the component COVID-19 target network of Longyi-Zhengqi
Formula and the component COVID-19 target network of Lianhua-Qingwen Formula. STRING was
used to construct a protein interaction network and screen key targets. GO (Gene Ontology) was
used for enrichment analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) was used for
pathways to find out the targets and pathways related to the treatment of COVID-19.

Results:
In the GO enrichment analysis results, there are 106 biological processes, 31 cell localization
and 28 molecular functions of the intersection PPI network targets of Longyi-Zhengqi Formula-
COVID-19, 224 biological processes, 51 cell localization and 55 molecular functions of the intersection
PPI network targets of Lianhua-Qingwen Formula-COVID-19. In the KEGG pathway analysis results,
the number of targets of Longyi-Zhengqi Formula on the COVID-19 pathway is 7, and the number
of targets of Lianhua-Qingwen Formula on the COVID-19 pathway is 19; In the regulation analysis
results, Longyi-Zhengqi Formula achieves the effect of treating COVID-19 by regulating IL-6, and
Lianhua-Qingwen Formula achieves the effect of treating pneumonia by regulating TLR4.

Conclusion:
This paper explores the mechanism of action of Longyi-Zhengqi Formula and
Lianhua-Qingwen Formula in treating COVID-19 based on the method of network pharmacology,
and provides a theoretical basis for traditional Chinese medicine to treat sudden diseases caused by
human coronavirus in terms of drug targets and disease interactions. It has certain practical significance.
Optimization of a Validated Liquid Chromatographic Method with
Chemometric Approach for Estimation of Eugenol from Seed Powder
Extract and Perform Anti-oxidant Activity
Authors: Ahmad Makhmur , Kaur Jasmeet , Khan Shamshir , Pallavi Mangesh Patil , Hashmi Sana , S. Roshan , Taleuzzaman Mohamad 
Published: April 2024

Background::
Developed and validated a new reverse phase high-performance liquid chromatographic (RP-HPLC) method, and it is prompt, precise, sensitive and robust for the esti-mation of eugenol in seed powder extract of Myristica fragrans.

Objective::
The chemometric approach was utilized to obtain a rugged and definitive chromato-graphic method for the purpose.

Methods::
Method variables such as acetonitrile (%) and flow rate were investigated for robust-ness and optimization by using a face-centered cubic design (FCCD). The Design Expert 12.0.1.0 software has been employed for this optimization. Further, the effects of factors were monitored on the concentrations of eugenol recovered from seed powder extract. Chromatograms have been developed by using an optimized mobile phase mixture containing methanol-water-acetonitrile (10:40:50, v/v/v) and Symmetry® C18 column (5 μm, 3.9 ×150 mm). The mobile phase was de-rived at a flow rate of 1 mL/min, and estimation of eugenol was performed at ʎmax 272 nm.

Results::
Validation of the method has been carried out to reveal its selectivity, linearity, preci-sion, accuracy, LOD, and LOQ. Linear calibration plot for eugenol was held over the concentra-tion across 6.25 and 100 μg/mL (R2 = 0.999). The coefficient of variation was less than 1%, and accurate recovery of eugenol was observed between 96.80 and 99.56 %. The LOD and LOQ have been established to be 1.97 and 6.25 μg/mL, respectively. Intraday and Inter-day coefficients of variation have 1.81-1.91 and 1.92-1.57, respectively. Antioxidant activity (AA) by DPPH assay of seed powder extract in five different solvents was performed, and % AA activity was calculat-ed against ascorbic acid.

Conclusion::
The validated method has been found to be highly robust and will be applied for the analysis of eugenol in formulation. The highest % AA has been reported in hexane solvent.
Риск-менеджмент в крупномасштабных проектах: принципы, инструменты управления, результаты
Authors: Симионова Нина Евгеньевна , Симионов Радомир Юрьевич 
Published: April 2024

На современном этапе развития экономических отношений с учетом внешних вызовов сформировались определенные предпосылки для применения проектного управления в деятельности отдельных хозяйствующих субъектов, а также на уровне исполнительной власти. Анализ результатов реализации нацио­нальных, федеральных, региональных и ведомственных проектов показал, что применение методологии и инструментария проектного управления дало положительные результаты в решении как экономических, так и социальных проблем. В то же время были выявлены проблемы государственного, регионального и отраслевого характера, которых можно избежать при правильно организованной системе управления рисками в проектах. Существующие стандарты по управлению рисками содержат принципы, на которых должна основываться система риск-менеджмента в проектах, но требуется их привязка к условиям национальных и других проектов, которые характеризуются масштабностью, длительным сроком реализации и большим количеством участников. Организация-участник проекта имеет собственные риски, на которые ориентирована система риск-менеджмента, но, попадая в новую систему взаимодействия организаций, возникают дополнительные риски. По мнению исследователей данной проблемы, необходимы новые механизмы не только в каждой организации, но также интегрированная система, охватывающая всех участников проекта. Авторы полагают, что одним из возможных инструментов управления риском в крупномасштабных проектах можно рассматривать сценарный подход к планированию проектов, что позволит наиболее обоснованно формировать финансовые резервы в системе управления рисками. Обеспечит более эффективное управление риском построение их иерархической структуры в виде дерева решений с рассмотрением альтернатив воздействия на риск. В системе управления риском необходимо предусматривать процесс улучшений как актуализацию рисков с учетом динамики факторов внешней и внутренней среды проекта.
Journal of Emerging Technologies in Accounting (JETA): Twenty Years of Growth and Innovation
Authors: Du Hui , Nehmer Robert A. 
Published: April 2024

ABSTRACT
The year 2024 marks the 20-year anniversary of Journal of Emerging Technologies in Accounting (JETA) since the journal published its first issue in 2004. We compiled JETA’s publication statistics for its first two decades. The statistics demonstrates the growth of JETA in 20 years and the innovation of the journal in the types and topics of articles being published. We also report detailed citations of JETA articles, including its top 15 most cited articles in those 20 years.
AUGMENTED REALITY PADA GAMBAR PAKAIAN SEBAGAI MEDIA PROMOSI
Authors: Putra Rachmat Mahardika , Aldya Aldy Putra , Hidayat Eka Wahyu 
Published: April 2024

Abstrak. Menghadapi persaingan yang semakin ketat. Perusahaan pakaian (PT. Ke-percayaan Bersama) semakin memperhatikan potensi Augmented Reality (AR) sebagai bagian dari strategi promosi untuk menginvestigasi dampak penerapan aplikasi dalam promosi merek pa-kaian. Hasil penelitian menunjukkan bahwa penerapan aplikasi AR dalam promosi merek pa-kaian secara signifikan menunjukkan keterlibatan konsumen lebih tinggi, dan berinteraksi secara lebih menarik dengan produk merek. Pengguna aplikasi AR ini menegaskan bahwa AR dapat dianggap sebagai alat bantu dalam meningkatkan keterlibatan konsumen. Evaluasi usabilitas aplikasi AR menggunakan Kuesioner System Usability Scale (SUS) menunjukkan hasil yang positif. Aplikasi AR memperoleh skor rata-rata sebesar 71, yang berada dalam kategori "Acceptable" (diterima). Ini menunjukkan bahwa aplikasi AR dianggap baik untuk digunakan oleh pengguna, dengan per-ingkat "Good" (baik) dalam segi usabilitas. Penelitian ini memberikan pandangan yang berharga tentang potensi teknologi AR dalam industri pakaian, serta memberikan dukungan empiris terhadap penggunaan aplikasi AR dalam upaya memperkuat merek dan memperbaiki pen-galaman konsumen. Hasil ini memberikan kontribusi yang signifikan bagi pemahaman tentang manfaat AR dalam konteks pemasaran merek pakaian, membuka peluang untuk pengembangan strategi promosi yang lebih interaktif. Abstract. Facing increasingly fierce competition, a clothing company (PT. Kepercayaan Bersama) is increasingly paying attention to the potential of Augmented Reality (AR) as part of its promotion strategy to investigate the impact of application in clothing brand promotion. The results showed that the application of AR applications in clothing brand promotion significantly showed higher consumer engagement, and interacted more interestingly with brand products, even improving brand perception among consumers. Users of this AR application confirmed that AR can be considered as a tool in increasing consumer engagement. The usability evaluation of the AR application using the System Usability Scale (SUS) questionnaire showed positive results. The AR app obtained an average score of 71, which is in the "Acceptable" category. This indicates that the AR application is considered good to use by users, with a rating of "Good" in terms of usability. This research provides valuable insights into the potential of AR technology in the apparel industry, as well as providing empirical support for the use of AR applications in efforts to strengthen brands and improve consumer experiences. These results make a significant contribution to the under-standing of the benefits of AR in the context of apparel brand marketing, opening up opportunities for the development of more interactive promotional strategies.
RANCANG BANGUN APLIKASI SISTEM INFORMASI INVENTARIS BERBASIS WEBSITE
Authors: Christian Chandra , Voutama Apriade 
Published: April 2024

Penggunaan layanan sistem informasi berbasis website telah banyak digunakan oleh berbagai sektor bisnis dalam beberapa tahun kedepan, hal ini disebabkan oleh meningkatnya akses internet dan juga adanya berbagai kebutuhan untuk mempermudah pengguna internet dalam mengakses informasi. Salah satu kebutuhannya yaitu Fakultas Ilmu Komputer Universitas Singaperbangsa Karawang dibutuhkan sebuah sistem informasi untuk mengakses data inventaris fakultas secara cepat dan akurat untuk mempermudah mobilisasi. Sehingga tujuan dari artikel ini yang berjudul Rancang Bangun Aplikasi Sistem Informasi Inventaris Berbasis Website adalah sebuah Sistem Informasi Inventaris berbasis website yang dapat diakses dioleh siapapun dan dimanapun menggunakan Framework Laravel yang digunakan pengguna untuk meminjam inventaris fakultas. Sistem Informasi Inventaris dikerjakan menggunakan metode Extreme Programming. Hasil dari penelitian ini adalah website sistem informasi inventaris yang pengguna bisa melihat dan meminjam barang. Serta pengujian website sistem informasi inventaris dilakukan menggunakan metode Blackbox Testing dengan hasil testing yang cukup valid sebagaimana mestinya.
Sistem 3D Monitoring Lintasan Roket Menggunakan Sensor IMU dan Kalman Filter
Authors: Fahriannur Ahmad , Karimah Cahyaning Nur 
Published: April 2024

Kompetisi Muatan Roket Indonesai Merupakan ajang kompetisi yang diselenggarakan oleh Lembaga Penerbangan dan Antariksa Nasional (LAPAN). Sensor Inertial Measurement Unit (IMU) ditempatkan kedalam muatan roket yang berfungsi untuk mendeteksi akselerasi dan kemiringan roket. Ketika roket diluncurkan, muatan berisi sensor dan perangkat kontrol mengirimkan data melalui gelombang radio secara real time ke ground control station (GCS) sebagai penerima untuk pengolahan data sensor. Penelitian ini membahas mengenai penerapan sensor IMU sebagai estimasi jarak peluncuran roket menggunakan metoda integral ganda, yang lintasan pegerakannya tergambar dalam bentuk grafik koordinat 3D. Kalman filter digunakan untuk mengurangi derau/noise pada sensor IMU supaya estimasi jarak terukurnya menjadi lebih akurat. Roket diluncurkan dilepas pantai menghadap ke arah laut dengan sudut elevasi 75o . Hasil pengujian menunjukkan lintasan roket pada kordinat (x,y,z) berhasil ditampilkan dengan koordinat awal (0,0,0) ke koordinat (414, 0, 891). Pengukuran estimasi jarak didapatkan bahwa ketinggian roket terukur sebesar + 891 meter dan jarak horizontal dari tempat peluncuran adalah sebesar + 414 meter.
Analisis Moisture Content dan Dew Point Gas SF6 PMT di GITET Gresik PT PLN (Persero) Transmisi Jawa Bagian Timur dan Bali
Authors: Ridwan Muhammad , Irawan Denny 
Published: April 2024

Gas Insulated Substation (GIS) adalah merupakan rangkaian dari beberapa peralatan yang terpasang dalam sebuah kompartemen dan diisolasi oleh gas yang bertekanan. Pada umumnya gas bertekanan yang digunakan adalah Sulfur Hexafluoride (SF6). Pada gas tersebut yang perlu diperhatikan adalah purity, moisture content, dewpoint dan kandungan SO2. Pada penelitian ini, metode yang dilakukan penulis adalah menganalisa hasil dari nilai uji dewpoint dan moisture content berdsarkan standar yang ditentukan dan menganalisa pengaruh suhu lingkungan terhadap nilai dewpoint. Pada penelitian ini penulis melakukan penelitian disebuah GIS yang ada naungan PT PLN (Persero) Unit Induk Transmisi Jawa Bagian Timur dan Bali yaitu GIS Gresik pada bay IBT 1 dan IBT 2 , dimana pada bay tersebut terdapat 4 PMT yaitu PMT 7AB1 dan PMT 7B1 untuk Bay IBT 1, dan PMT 7AB3 dan PMT 7A3 untuk Bay IBT 2. Nilai dewpoint dan moisture content pada keempat PMT tersebut masih dibawah standar yang ditentukan oleh PT PLN (Persero) yaitu -50C, dan nilai moisture content <3960 ppmv atau <400 pa (T = 20OC) sehingga tidak perlu dilakukan penggantian gas SF6.
Sistem Parkir Berbasis Radio Frequency identification
Authors: Dwi Nugraha Amin Alqudri , Eliza Fivia , Candra Oriza , Elfizon Elfizon 
Published: April 2024

Seiring meningkatnya pertumbuhan penduduk, maka penggunaan kendaraan juga meningkat. Dikarenakan semakin banyaknya penggunaan kendaraan, maka timbul keresahan pada masyarakat ketika hendak mermarkirkan kendarannya di tempat umum. Hal ini dikarenakan kesulitan dalam mencari ruang parkir yang kosong dan juga pemborosan waktu serta konsumsi bahan bakar yang terbuang percuma. Oleh karena itu dibuatkan sebuah alat yang bertujuan untuk dapat merancang dan memonitoring sistem sistem parkiran menggunakan android melalui sensor photodioda, ultrasonik dan RFID (Radio frequency identification) dengan output motor power servo dan DFPlayermini melalui arduino ESP32. Metode sistem parkiran menggunakan android melalui sensor photodioda, ultrasonik dan RFID (Radio frequency identification) dengan output motor power servo dan DFPlayermini melalui arduino ESP32 diaktifkan melalui Wi-Fi menggunakan inputan kondisi dari sensor photodiode, ultrasonic dan RFID melalui firebase berupa data realtime yang aktif dan jika RFID terdaftar maka akan mengkatifkan motor servo untuk membuka dan menutup palang parkiran yang setelah itu dikirimkan datanya menuju database firebase dan suara dari DFPlayer Mini dan speaker. Setelah melakukan pengujian dan analisa terhadap sistem parkiran menggunakan android melalui sensor photodioda, ultrasonik dan RFID (Radio frequency identification) dengan output motor power servo dan DFPlayermini melalui arduino ESP32 dapat diambil kesimpulan bahwa sistem sistem parkiran berbasis Radio frequency identification telah dapat bekerja dengan baik sesuai dengan rancangan prinsip kerja dan hasil yang dicapai sesuai fungsi serta kerja alat.
Advanced glycation end products of dietary origin and their association with inflammation in diabetes – A minireview
Authors: Pedreanez Adriana , Robalino Jorge , Tene Diego , Salazar Patricio 
Published: April 2024

Abstract
Advanced glycation end products (AGEs) are a diverse group of compounds that are formed as a result of the non-enzymatic reaction between a reducing sugar such as glucose and the free NH2 groups of an amino acid in a protein or other biomolecule. The chemical reaction, by which these products are generated, is known as the Maillard reaction and occurs as a part of the body’s normal metabolism. Such a reaction is enhanced during diabetes due to hyperglycemia, but it can also occur during the preparation, processing, and preservation of certain foods. Therefore, AGEs can also be obtained from the diet (d-AGE) and contribute to an increase of the total serum pool of these compounds. They have been implicated in a wide variety of pathological processes, mainly because of their ability to induce inflammatory responses and oxidative stress increase. They are extensively accumulated as a part of the normal aging, especially in tissues rich in long half-life proteins, which can compromise the physiology of these tissues. d-AGEs are abundant in diets rich in processed fats and sugars. This review is addressed to the current knowledge on these products and their impact on the immunomodulation of various mechanisms that may contribute to exacerbation of the diabetes pathophysiology.
Determinants of Trade Flow in the Economic Community of Central African States (ECCAS): Does Governance Matter?
Authors: Olaifa Felix Gbenga , Olubiyi Ebenezer Adesoji , Benjamin Oluwasegun Olawale 
Published: April 2024

Abstract

Subject and purpose of work:
This study analyzes the determinants of intra-ECCAS trade, with special attention paid to the role of institutional quality from 1996 to 2021.

Materials and methods:
The study conducts descriptive analysis and utilizes a Negative Binomial Pseudo Maximum Likelihood to analyze the determinants of intra-ECCAS trade.

Results:
The results suggest that gross domestic product (GDP), population, time taken for export shipment in the exporting countries and the bilateral real exchange rate of the importing partner country enhance intra-ECCAS trade flow. On the other hand, distance, two trading partners being landlocked, time for importing countries and bilateral real exchange rate of the exporting partner discourage this. Furthermore, the findings reveal that institutions are vital to intra-ECCAS trade.

Conclusions:
T he key d rivers of intra-ECCAS t rade a re GDP, population, t ime t aken for export shipment in the exporting countries, bilateral real exchange rate of the importing partner country, and institutions’ quality measures.
Behavioral Aspects of Investments in Renewable Energy Sources on the Example of Podkarpackie Province
Authors: Szara Katarzyna 
Published: April 2024

Abstract

Subject and purpose of work:
The subject of the study consists of the biasess made when investing in photovoltaic panels. The purpose of the study is to identify biasess associated with investing in renewable energy sources.

Materials and methods:
Data from a survey conducted among owners of photovoltaic installations in Subcarpathia were used. The literature has identified papers on factors other than behavioral errors affecting investments in photovoltaic panels.

Results:
Respondents succumbed to the anchoring effect, the error of positive retrospection, information bias, choice-supportive bias and framing bias when deciding to invest in photovoltaic panels.

Conclusions:
The research conducted makes it possible to confirm that people’s behavior while investing is influenced by non-economic factors. Knowledge of behavioral biases can allow one to calibrate financial incentives in order to influence customers more effectively.
A Voluntary Divide? Exploring the Role of Digitalisation in German Rural Volunteering
Authors: Thewes Christoph , Sept Ariane , Richter Ralph 
Published: April 2024

Abstract
Rural communities have experienced significant changes in their social, economic and demographic structures, leading to an increased importance of volunteering. Such activities are related to traditional association structures, which seem to be declining in popularity. One of the current hopes for strengthening rural volunteering is digitalisation. This article examines the extent to which digitalisation has found its way into volunteering and how this is related to rural areas. It summarises the discourses on volunteering, rural areas and digitalisation and introduces a mixed-methods approach at the organisational level. Based on a nationwide survey and in-depth interviews with volunteers and experts, we present a digitalisation index to illustrate that digitalisation has found its way into rural volunteering, but not to the same extent everywhere. We suggest that the sparse use of distance-bridging digital tools is due to the structural peculiarities of rural voluntary organisations rather than stereotypical rural backwardness.