bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines
Authors: Jung Tae-Young , Jung Shin , Ryu Hyang-Hwa , Jeong Young-Il , Jin Yong-Hao , Jin Shu-Guang , Kim In-Young , Kang Sam-Suk , Kim Hyung-Seok 
Published: July 2008

Object
Galectin-1 is highly expressed in motile cell lines. The authors investigated whether galectin-1 actually modulates the migration and invasion of human glioblastoma multiforme (GBM) cell lines, and whether its expression with respect to invasion and prognosis is attributable to certain glioma subgroups.

Methods
In the human GBM cell lines U343MG-A, U87MG, and U87MG-10′, the RNA differential display was evaluated using Genefishing technology. The results were validated by reverse transcription polymerase chain reaction and Northern blot analysis to detect possible genetic changes as the determining factors for the motility of the malignant glioma. The migration and invasion abilities were investigated in human GBM cell lines and galectin-1 transfectant using an in vitro brain slice invasion model and a simple scratch technique. The morphological and cytoskeletal (such as the development of actin and vimentin) changes were examined under light and confocal microscopy. Galectin-1 expression was assessed on immunohistochemical tests and Western blot analysis.

Results
Endogenous galectin-1 expression in the human GBM cell lines was statistically correlated with migratory abilities and invasiveness. The U87-G-AS cells became more round than the U87MG cells and lacked lamellipodia. On immunohistochemical staining, galectin-1 expression was increased in higher-grade glioma subgroups (p = 0.027).

Conclusions
Diffuse gliomas demonstrated higher expression levels than pilocytic astrocytoma in the Western blot. Galectin-1 appears to modulate migration and invasion in human glioma cell lines and may play a role in tumor progression and invasiveness in human gliomas.
Multiple fusiform myxomatous cerebral aneurysms in a patient with Carney complex
Authors: Ryou Kyoung Soo , Lee Sun-Ho , Park Seong-Hyun , Park Jaechan , Hwang Sung-Kyoo , Hamm In-Suk 
Published: July 2008

Carney complex is a rare autosomal-dominant familial tumor syndrome that involves the triad of myxoma, mucocutaneous pigmentation, and endocrine overactivity. To the best of the authors' knowledge, there are no reports of multiple fusiform aneurysms coinciding with atrial myxoma.
The authors report the case of a 38-year-old woman with typical Carney complex who had multiple skin myxomas, endocrine abnormalities, and multiple brownish perioral lesions. Multiple fusiform aneurysms were also discovered after the recurrence of atrial myxoma. During a follow-up period of > 10 years, there have been no angiographic changes in the aneurysms and no progression of symptoms.
Germ cell tumors in the basal ganglia: problems of early diagnosis and treatment
Authors: Sonoda Yukihiko , Kumabe Toshihiro , Sugiyama Shin-Ichiro , Kanamori Masayuki , Yamashita Yoji , Saito Ryuta , Ariga Hisanori , Takai Yoshihiro , Tominaga Teiji 
Published: July 2008

Object
Intracranial germ cell tumors (GCTs) originating in the basal ganglia are rare. The authors investigated factors related to the diagnosis of these lesions as well as outcome in order to help decrease the time to diagnosis and improve treatment efficacy.

Methods
The authors reviewed the clinical features of 142 cases of intracranial GCT in their institute. Fourteen cases of basal ganglia GCT were identified. The symptoms, neuroimaging findings, delay between symptom onset and diagnosis or treatment, initial and further treatment, and outcome were investigated.

Results
Major symptoms were motor weakness and precocious puberty. Gadolinium-enhanced T1-weighted MR images showed enhancement in 8 of 11 patients examined, but only slight hyperintensity without enhancement in 2 patients. Ipsilateral peduncle and hemispheric atrophy were found in 3 and 4 patients, respectively. Cases of basal ganglia GCT were characterized by a longer delay from the initial neuroimaging examination to diagnosis compared with GCT in other regions. Five patients had aggravated hemiparesis in the extremities due to the delay in diagnosis. Despite good response to the initial therapy, 5 patients experienced recurrence; 2 of these 5 had malignant GCTs, and 3 had been treated only with chemotherapy or radiochemotherapy with insufficient radiation dose and field. Finally, the 2 patients with malignant GCTs died of the disease, and 1 died of aspiration pneumonia due to dissemination around the brainstem.

Conclusions
Early diagnosis requires MR imaging with administration of contrast medium in young patients presenting with motor weakness and/or precocious puberty. Serial neuroimaging studies should be performed if any tiny lesion is detected in the basal ganglia. Since insufficient treatment resulted in early recurrence, radiation therapy with adequate dose and field is essential.
Vascular and apoptotic changes in the placode of myelomeningocele mice during the final stages of in utero development
Authors: Reis Joaquim L. , Correia-Pinto Jorge , Monteiro Mariana P. , Costa Madalena , Hutchins Grover M. 
Published: July 2008

Object
Myelomeningocele (MMC) is a primary neurulation defect that is associated with devastating neurological disabilities in affected newborns. To better characterize the in utero neurodegenerative process of MMC, the authors investigated the changes in vascular organization, apoptosis, and the presence of inflammatory cells during gestation by using a mutant mouse model of MMC.

Methods
The curly tail/loop tail (ct/lp) mutant mouse model of MMC was chosen to obtain fetuses at different stages of gestation. Mouse fetuses harboring MMC were harvested by caesarean section at embryonic Days 14.5, 16.5, and 18.5 (complete mouse gestation at 19 days, 6 mice/group); littermate fetuses with the same gestational age but without an MMC were used as controls. Samples of the MMC placode or normal spinal cord were stained for immunocytochemical labeling with caveolin antibody (endothelium marker) and activated caspase-3 antibody (apoptosis marker). Samples were morphometrically analyzed with a computer-assisted image analyzer.

Results
The MMC mice presented with an increase in vascular density from embryonic Days 16.5–18.5 and an enhanced number of apoptotic cells at embryonic Day 18.5, compared with controls. There were scarce signals of an inflammatory reaction in the MMC placode, as a few infiltrating neutrophils were seen only at embryonic Day 18.5.

Conclusions
Fetal placodes in MMC mice showed evidence of increased vascular density since embryonic Day 16.5 and increased apoptosis at embryonic Day 18.5. These new data support the view that in utero changes of the MMC placode, occurring during the last stages of gestation, contribute to the neuropathological manifestations in full-term newborns with MMC.
Catalytic Deprotonative Functionalization of Propargyl Silyl Ethers with Imines
Authors: Naka Hiroshi , Koseki Daiki , Kondo Yoshinori 
Published: July 2008

AbstractA metal‐free, catalytic CH functionalization of propargyl silyl ethers with imines using the phosphazene base (t‐Bu‐P4base) provides structurally defined multisubstituted pyrroles in modest to excellent yields under mild conditions. A one‐pot, three‐component reaction using silylated acetylenes, aldehydes, and imines is also presented.
Bismaleimides, bisnadimides, and polyaspartimides containing ether and ester linkages and pyridine
Authors: Amutha N. , Sarojadevi M. 
Published: July 2008

AbstractA series of bismaleimides (BMI) and bisnadimides (BNI) containing pyridine ring and flexible linkages were prepared and the structural characterization of the resins was carried out by elemental analysis, FTIR, 1H NMR, and 13C NMR spectroscopy. Their curing behavior were characterized by differential scanning calorimetry and thermal stability of the cured resins were investigated by thermogravimetric analysis. In addition, a series of polyaspartimides were prepared by the polyaddition of the bismalemide with various dimaines. The polymers were characterized by FT‐IR, inherent viscosity, and molecular weight measurements. All the polyimides were soluble in many organic solvents, the glass transition temperature of the polyaspartimides are in the range of 194–231°C, 10% weight loss (T10) takes place in the temperature range of 379–482°C in N2 and char yield in the range of 44.31–53.31%. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Identifying clusters of user behavior in intranet search engine log files
Authors: Stenmark Dick 
Published: July 2008

AbstractWhen studying how ordinary Web users interact with Web search engines, researchers tend to either treat the users as a homogeneous group or group them according to search experience. Neither approach is sufficient, we argue, to capture the variety in behavior that is known to exist among searchers. By applying automatic clustering technique based on self‐organizing maps to search engine log files from a corporate intranet, we show that users can be usefully separated into distinguishable segments based on their actual search behavior. Based on these segments, future tools for information seeking and retrieval can be targeted to specific segments rather than just made to fit the “the average user.” The exact number of clusters, and to some extent their characteristics, can be expected to vary between intranets, but our results indicate that some more generic groups may exist. In our study, a large group of users appeared to be “fact seekers” who would benefit from higher precision, a smaller group of users were more holistically oriented and would likely benefit from higher recall, and a third category of users seemed to constitute the knowledgeable users. These three groups may raise different design implications for search‐tool developers.
Carbimazole embryopathy‐bilateral choanal atresia and patent vitello‐intestinal duct: A case report and review of literature
Authors: Kannan Lakshminarayanan , Mishra Satish , Agarwal Ramesh , Kartikeyan Venkat , Gupta Neerja , Kabra Madhulika 
Published: July 2008

AbstractBACKGROUND: In utero exposure to carbimazole for maternal hyperthyroidism has been reported to cause choanal atresia. There are case reports of patent vitello‐intestinal duct and Meckel's diverticulum in similar association. CASE: We report another such instance of an infant who was exposed to carbimazole in utero, presenting with bilateral choanal atresia and patent vitello‐intestinal duct. CONCLUSIONS: As there seems to be no reports of a possible association between propylthiouracil and congenital malformations, it may be safer to use propylthiouracil instead of carbimazole. Birth Defects Research (Part A), 2008. © 2008 Wiley‐Liss, Inc.
Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: Evaluation of the teratogenic effects of its amide derivatives in NMRI mice
Authors: Okada Akinobu , Onishi Yuko , Yagen Boris , Shimshoni Jakob Avi , Kaufmann Dan , Bialer Meir , Fujiwara Michio 
Published: July 2008

AbstractBACKGROUND: Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA analogue, 2,2,3,3‐tetramethylcyclopropanecarboxamide (TMCD), N‐methyl‐TMCD (MTMCD), 4‐(2,2,3,3‐tetramethylcyclopropanecarboxamide)‐benzenesulfonamide (TMCD‐benzenesulfonamide), and 5‐(TMCD)‐1,3,4‐thiadiazole‐2‐sulfonamide (TMCD‐thiadiazolesulfonamide) were synthesized and shown to have more potent anticonvulsant activity than VPA. Teratogenic effects of these CNS‐active compounds were evaluated in Naval Medical Research Institute (NMRI) mice susceptible to VPA‐induced teratogenicity by comparing them to those of VPA. METHODS: Pregnant NMRI mice were given a single sc injection of either VPA or TMC‐amide derivatives on gestation day 8.5, and then the live fetuses were examined to detect any external malformations on gestation day 18. After double‐staining for bone and cartilage, their skeletons were examined. RESULTS: In contrast to VPA, which induced NTDs in a high number of fetuses at 2.4–4.8 mmol/kg, TMCD, TMCD‐benzenesulfonamide, and TMCD‐thiadiazolesulfonamide at 4.8 mmol/kg and MTMCD at 3.6 mmol/kg did not induce a significant number of NTDs. TMCD‐thiadiazolesulfonamide exhibited a potential to induce limb defects in fetuses. Skeletal examination also revealed that fetuses exposed to all four of the tetramethylcyclopropanecarboxamide derivatives developed vertebral and rib abnormalities less frequently than those exposed to VPA. Our results established that TMCD, MTMCD, and TMCD‐benzenesulfonamide are distinctly less teratogenic than VPA in NMRI mice. CONCLUSIONS: The CNS‐active amides containing a tetramethylcyclopropanecarbonyl moiety demonstrated better anticonvulsant potency compared to VPA and a lack of teratogenicity, which makes these compounds good second‐generation VPA antiepileptic drug candidates. Birth Defects Research (Part A), 2008. © 2008 Wiley‐Liss, Inc.
Bridging Excel and C/C++ code
Authors: Punuru Janardhana R. , Knopf F. Carl 
Published: July 2008

AbstractMicrosoft Excel provides a flexible pre‐ and post‐processor for low‐level languages such as C/C++. Here details are provided to allow single variables, vectors and matrices to pass from Excel ↔ VBA ↔ C/C++ programs. Passing single variables and vectors is straightforward. Passing matrices requires understanding of row‐major and column‐major storage strategies. Simple examples utilizing each data type are shown. © 2008 Wiley Periodicals, Inc. Comput Appl Eng Educ 16: 289–304, 2008; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae20146
Ethical challenges in conducting research with hard to reach families
Authors: Gorin Sarah , Hooper Carol‐Ann , Dyson Claire , Cabral Christie 
Published: July 2008

AbstractThis paper reflects on some of the ethical challenges encountered by the authors whilst undertaking sensitive qualitative research with parents and children who are traditionally hard to reach. The research aimed to provide more holistic and in‐depth accounts of parenting on a low income in diverse social circumstances than already exist. The nature of the sample and the subject matter that was covered inevitably raised many familiar ethical dilemmas and some that are less often encountered in practice, particularly in relation to child protection. In this article we discuss our approach to ethics, some of the ethical challenges we encountered undertaking work with families and discuss the complexity of decision‐making around risk of harm to children. We conclude that a clear framework to avoid harm should be developed at the outset and a transparent approach to child protection issues should be used. Additional time and resources need to be incorporated at the planning stage of similar projects in order to develop appropriate methods, ensure effective decision‐making and support researchers. Copyright © 2008 John Wiley & Sons, Ltd.
Cleveland 20 years on: what have we learned about intervening in child sexual abuse?
Authors: Bacon Heather 
Published: July 2008

AbstractThis is the first of two linked papers. It examines the main changes in approach to child sexual abuse that have occurred since the events in Cleveland 20 years ago. Comparison between estimated prevalence rates and registrations for sexual abuse suggests that we are aware of only the tip of the iceberg. It is argued that in many cases uncertainty may have to be accepted, and that protection may be better achieved through a protective parent than through the child protection system. Clinical examples of cases presenting to a specialist child and adolescent mental health service are given. It is argued that, although society is now more willing to recognise the existence of child sexual abuse and professionals are better at dealing with families, outcomes for this group of children are not much improved. Copyright © 2008 John Wiley & Sons, Ltd.
Cleveland 20 years on: themes of disruption and repair in the trauma narratives of children, adults and society
Authors: Richardson Sue 
Published: July 2008

AbstractThis is the second of two linked papers which explores coherent and incoherent narratives emerging from Cleveland. It draws a parallel between the disrupted narratives of child and adult survivors of child sexual abuse and professional and societal narratives of Cleveland. The paper looks at the therapeutic task of individual repair using attachment‐based therapy, illustrated by clinical examples. It identifies five key challenges relevant to repair in the interpersonal, intra‐personal and societal domains. Copyright © 2008 John Wiley & Sons, Ltd.
A current overview of consumer neuroscience
Authors: Hubert Mirja , Kenning Peter 
Published: July 2008

Abstract

The emerging discipline of neuroeconomics employs methods originally used in brain research for investigating economic problems, and furthers the advance of integrating neuroscientific findings into the economic sciences. Neuromarketing or consumer neuroscience is a sub‐area of neuroeconomics that addresses marketing relevant problems with methods and insights from brain research. With the help of advanced techniques of neurology, which are applied in the field of consumer neuroscience, a more direct view into the “black box” of the organism should be feasible. Consumer neuroscience, still in its infancy, should not be seen as a challenge to traditional consumer research, but constitutes a complementing advancement for further investigation of specific decision‐making behavior.

The key contribution of this paper is to suggest a distinct definition of consumer neuroscience as the scientific proceeding, and neuromarketing as the application of these findings within the scope of managerial practice. Furthermore, we aim to develop a foundational understanding of the field, moving away from the derisory assumption that consumer neuroscience is about locating the “buy button” in the brain. Against this background the goal of this paper is to present specific results of selected studies from this emerging discipline, classified according to traditional marketing‐mix instruments such as product, price, communication, and distribution policies, as well as brand research. The paper is completed by an overview of the most prominent brain structures relevant for consumer neuroscience, and a discussion of possible implications of these insights for economic theory and practice.

Copyright © 2008 John Wiley & Sons, Ltd.
What they see is what they get? An fMRI‐study on neural correlates of attractive packaging
Authors: Stoll Marco , Baecke Sebastian , Kenning Peter 
Published: July 2008

Abstract

There is evidence in neuroscience that the brain processes negative visual stimuli in a different manner than positive ones. Our study investigates, whether it is possible to transfer these findings to one specific, often‐neglected marketing stimulus, package design. For this purpose, we measured the brain activity of subjects while they had to make decisions about the attractiveness of certain fast moving consumer good packages. As predicted by consumer neuroscience, we found that attractive and unattractive packages are able to trigger different cortical activity changes. Contrasting attractive versus unattractive packages, revealed significant cortical activity changes in visual areas of the occipital lobe and the precuneus – regions associated with the processing of visual stimuli and attention. On the individual level, we found significant activity changes within regions of reward processing. On the other hand by contrasting unattractive versus attractive packages we found an increased activity in areas of the frontal lobe and insula cortex, regions often associated with processing aversive stimuli such as unfair offers or disgusting pictures. Although, these results are without any doubt preliminary they might explain why attractive packages gain more attention at the point‐of‐sale and this, in turn, positively influences turnovers of fast moving consumer goods.

Copyright © 2008 John Wiley & Sons, Ltd.
Brain metastasis from renal cell carcinoma
Authors: Shuch Brian , La Rochelle Jeff C. , Klatte Tobias , Riggs Stephen B. , Liu Weiqing , Kabbinavar Fairooz F. , Pantuck Allan J. , Belldegrun Arie S. 
Published: July 2008

AbstractBACKGROUND.Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guidelines.METHODS.Patients undergoing evaluation for RCCBM from 1989 to 2006 were identified. Their characteristics, symptoms, pathologic variables, number and size of RCCBM, CNS treatment, CNS recurrence, overall survival, and use of systemic therapy were reviewed.RESULTS.A total of 138 patients were identified with RCCBM, of whom 92% had clear cell RCC and 95% had synchronous extracranial metastases. CNS symptoms were noted in 67% of patients. Symptomatic CNS tumors were larger (2.1 cm vs 1.3 cm; P < .001) and more frequently required a craniotomy (P < .001). The median overall survival after a diagnosis of RCCBM was 10.7 months; the 1‐year, 2‐year, and 5‐year survival rates were 48%, 30%, and 12%, respectively. Median CNS recurrence was 9 months after RCCBM treatment. The initial number of tumors (>1 tumor) was found to be an independent predictor of CNS recurrence (hazards ratio of 3.72; P < .001). Those patients with 1 and >1 lesion had a median CNS recurrence‐free survival of 13 months and 4 months, respectively (P < .001). Patients receiving interleukin‐2 after CNS treatment had a response rate of 17%.CONCLUSIONS.Patients with metastatic RCC should undergo CNS screening to allow the identification of smaller lesions that are more amenable to treatment. Those patients with solitary RCCBM are less likely to develop CNS recurrence after local therapy. Selected patients with good performance status may exhibit prolonged survival and should be offered aggressive therapy. Cancer 2008. © 2008 American Cancer Society.