bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the effect of disc displacement on the risk and severity of condylar erosion in adult temporomandibular disorder patients: A CBCT and MRI study
Authors: Fan Pei‐Di , Han Sophie Lau Rui , Cheng Qiao‐Yu , Dan Rui‐Chen , Cheng Jun‐Xin , Tian Yi‐Hong , Xiang Jie , Wang Jun , Xiong Xin 
Published: March 2024

AbstractObjectiveThe objective of the study was to investigate the relationship between types of disc displacement (DD) diagnosed by magnetic resonance imaging (MRI), and the risk (presence or absence) and severity of condylar erosion (CE) graded using cone‐beam computed tomography (CBCT) in adult Temporomandibular disorders (TMD) patients.MethodsA total of 353 TMD patients (283 females, 70 males) underwent MRI scans to categorise DD as normal (NA), anterior displacement with reduction (ADDR), or anterior displacement without reduction (ADDNR). CE severity was graded on a scale of 0–3 (absence, mild, moderate or severe) using CBCT. To establish the plausibility and cut‐off points for CE diagnosis, the severity of CE was then further divided into three classifications: Grade 0 versus 1 + 2 + 3; Grades 0 + 1 versus 2 + 3; Grades 0 + 1 + 2 versus 3. Logistic regression analysis was performed, adjusting for age, gender and joint correlation.ResultsADDNR significantly increased the risk of CE compared with NA (OR = 10.04, 95% CI: [6.41, 15.73]) and showed a significant increase in CE severity across all classifications (ORs = 10.04–18.95). The effects of ADDNR were significant in both genders (p < .001) and had a greater impact in females. ADDR was predominantly associated with mild CE.ConclusionsADDNR significantly increased the risk and severity of CE independent of gender when compared to NA, whereas ADDR was mainly associated with mild CE. Slight cortical discontinuity may represent a subclinical diagnosis requiring further investigation.
Implant survival rate and marginal bone loss of 174 implants with different variables associated over a minimum observational period of 20 years: A retrospective study
Authors: Carossa Massimo , Pera Francesco , Alovisi Mario , Ponzio Michele , Schierano Gianmario , Migliaretti Giuseppe , Carossa Stefano , Scotti Nicola 
Published: March 2024

AbstractPurposeTo investigate the long‐term implant survival rate and marginal bone loss (MBL) of implants with different variables associated over an observational period of at least 20 years.Materials and MethodsPatients with at least one implant placed prior to 2001 were recalled and visited. Data on implant macro‐design, prosthetic aspects, site distribution, and patient‐related factors were collected. MBL was evaluated on intraoral X‐rays and peri‐implant soft tissue parameters were recorded. The patients were asked to fill out a questionnaire to evaluate their satisfaction with the treatment received. Descriptive statistics indicators were estimated. Analysis of variance and analysis of covariance models were used to investigate any differences in the MBL and peri‐implant probing depth (PPD) among the variables. A chi‐square analysis was performed to investigate any association between different types of prosthetic implant‐supported rehabilitations and survival/success outcomes.ResultsForty‐one (41) patients and 174 implants were included with a mean observational period of 23.3 ± 2.8 years. The implant survival and success rates were 96.5% and 83.3% respectively, while 3.5% of early failures were detected. The lowest success rates were observed for implants supporting fixed full‐arch rehabilitations (71.05%) and overdenture rehabilitations (86.11%). A mean MBL of 1.81 ± 0.71 mm and a mean PPD of 3.38 ± 1.62 mm were recorded. The interaction between the collected data with MBL and PPD did not reveal any statistically significant differences between the variables (p > 0.05). A statistically significant difference was recorded when analyzing the association between the different types of prosthetic implant‐supported rehabilitations and success rates (p = 0.014), with fixed and removable full‐arch rehabilitations presenting with lower success rates. Answers to the questionnaire showed a generally high level of satisfaction.ConclusionsWithin the limits of this retrospective study and based on the results, an implant survival rate higher than 96% was observed after a mean observational period of 23.3 ± 2.8 years. Both the implant survival rate and MBL seemed stable after a mean observational period of 23.3 ± 2.8 years. Implants supporting fixed and removable full‐arch rehabilitations seemed to present lower success rates over time. Implant rehabilitation seemed to provide patients with optimal long‐term outcomes in terms of functional and psychological aspects.
Age‐related changes in sweetness perception: Exploring the role of cross‐modal interactions
Authors: Romeo‐Arroyo Elena , Mora María , Boronat Òscar , Vázquez‐Araújo Laura 
Published: March 2024

AbstractCrossmodal strategies have been proven to be useful to enhance sweetness perception, although, in general, the segmentation of consumers is not an essential part of this kind of research. The aim of the present study was to determine if a set of crossmodal strategies could be useful to modify sweetness perception in three different age groups: young, middle‐aged, and senior adults. A butter cookie and a milkshake sample were reformulated (appearance and aroma of both samples, and the mouthfeel of the milkshake) to assess liking and perception of overall flavor and sweetness intensities. Results suggested that adding a sweet‐related aroma enhanced sweet taste/flavor intensity, without affecting liking ratings, for all the studied age groups. Liking and the ratings for flavor and sweetness intensity were significantly different among age groups, but no interactions “sample x age” were identified, suggesting that crossmodal interactions were similar for all age groups.Practical ApplicationsThe growing demand for low‐sugar foods has led food companies to reformulate their products, requiring research into the best ways to develop successful low‐sugar alternatives. Research on potential crossmodal interactions is useful to guide companies to attend consumers' demands, but there is a lack of information on how to adapt the most successful strategies to each consumer segment (beyond cross‐cultural studies). Results of the present research include interesting data on three different consumers' segments and their perception of two kinds of products in which cross‐modal strategies were used to reformulate a control sample: a solid food ‐exemplified using a butter cookie‐ and a beverage ‐exemplified using a milkshake‐.
Revealing the algicidal characteristics of Maribacter dokdonensis: An investigation into bacterial strain P4 isolated from Karenia mikimotoi bloom water
Authors: Lee Thomas Chun‐Hung , Lam Winnie , Tam Nora Fung‐Yee , Xu Steven Jing‐Liang , Chung Wing Lam , Lee Fred Wang‐Fat 
Published: March 2024

AbstractHarmful algal blooms (HABs) are a global environmental concern, causing significant economic losses in fisheries and posing risks to human health. Algicidal bacteria have been suggested as a potential solution to control HABs, but their algicidal efficacy is influenced by various factors. This study aimed to characterize a novel algicidal bacterium, Maribacter dokdonensis (P4), isolated from a Karenia mikimotoi (Hong Kong strain, KMHK) HAB and assess the impact of P4 and KMHK's doses, growth phase, and algicidal mode and the axenicity of KMHK on P4's algicidal effect. Our results demonstrated that the algicidal effect of P4 was dose‐dependent, with the highest efficacy at a dose of 25% v/v. The study also determined that P4's algicidal effect was indirect, with the P4 culture and the supernatant, but not the bacterial cells, showing significant effects. The algicidal efficacy was higher when both P4 and KMHK were in the stationary phase. Furthermore, the P4 culture at the log phase could effectively kill KMHK cells at the stationary phase, with higher algicidal efficacy in the bacterial culture than that of the supernatant alone. Interestingly, P4's algicidal efficacy was significantly higher when co‐culturing with xenic KMHK (~90% efficacy at day 1) than that with the axenic KMHK (~50% efficacy at day 1), suggesting the presence of other bacteria could regulate P4's algicidal effect. The bacterial strain P4 also exhibited remarkable algicidal efficacy on four other dinoflagellate species, particularly the armored species. These results provide valuable insights into the algicidal effect of M. dokdonensis on K. mikimotoi and on their interactions.
Visualising cervical lymph nodes in jaw osteonecrosis using diffusion‐weighted imaging
Authors: Muraoka Hirotaka , Kaneda Takashi , Kondo Takumi , Otsuka Kohei , Tokunaga Satoshi 
Published: March 2024

AbstractObjectivesThis study aimed to apply diffusion‐weighted imaging to the evaluation of cervical lymph nodes affected by medication‐related osteonecrosis of the jaw (MRONJ).MethodsThis retrospective study analysed the diffusion‐weighted imaging data of 70 patients with or without MRONJ (Stages 0–3). The mean apparent diffusion coefficient (ADC) values of the submandibular (level IB) and superior internal jugular (level IIA) nodes in the control and MRONJ groups were calculated, and differences were analysed using the Mann–Whitney test. Moreover, receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of ADC values to predict lymph nodes that were affected by MRONJ. p < 0.05 was considered statistically significant.ResultsThe median [interquartile range] (×10−3 mm2/s) of level IB was 0.74 [0.7–0.81] and 0.93 [0.84–1.09] and that of level IIA was 0.79 [0.76–0.85] and 0.97 [0.84–1.06] in the control and MRONJ groups respectively. ROC analysis revealed that the ADC value had excellent ability to discriminate between the control and MRONJ groups.ConclusionsThe study findings indicate that diffusion‐weighted imaging can contribute to differentiation of MRONJ from other cervical lymph node diseases and facilitate early detection of MRONJ.
Neural consequences of symptomatic convergence insufficiency: A small sample study
Authors: Zeng Yuxuan , Oechslin Tamara S. , Widmer Douglas E. , Kulp Marjean T. , Fogt Nicklaus , Toole Andrew , Manning Steven , Osher David E. 
Published: March 2024

AbstractIntroductionConvergence insufficiency (CI) is an oculomotor abnormality characterised by exophoria and inadequate convergence when focusing on nearby objects. CI has been shown to cause symptoms when reading. However, the downstream consequences on brain structure have yet to be investigated. Here, we investigated the neural consequences of symptomatic CI, focusing on the left arcuate fasciculus, a bundle of white matter fibres which supports reading ability and has been associated with reading deficits.MethodsWe compared the arcuate fasciculus microstructure of participants with symptomatic CI versus normal binocular vision (NBV). Six CI participants and seven NBV controls were included in the analysis. All participants were scanned with 3 T magnetic resonance imaging (MRI), and anatomical and diffusion‐weighted images were acquired. Diffusion‐weighted images were processed with TRACULA to identify the arcuate fasciculus in each participant and compute volume and radial diffusivity (RD).ResultsCompared with NBV controls, those with symptomatic CI had significantly smaller arcuate fasciculi bilaterally (left: t = −3.21, p = 0.008; right: t = −3.29, p = 0.007), and lower RD in the left (t = −2.66, p = 0.02), but not the right (t = −0.81, p = 0.44, false discovery rate (FDR)‐corrected p > 0.05) arcuate fasciculus. Those with higher levels of reading symptoms had smaller arcuate fasciculi (r = −0.74, p = 0.004) with lower RD (r = −0.61, p = 0.03).ConclusionsThese findings suggest that symptomatic CI may lead to microstructural changes in the arcuate fasciculus. Since it is highly unlikely that abnormalities in the arcuate fasciculus are the cause of the neuromuscular deficits in the eyes, we argue that these changes may be a potential neuroplastic consequence of disruptions in sustained reading.
Barriers to healthcare access for children with congenital heart disease in eight Latin American countries
Authors: Lopez‐Barreda Rodrigo , Schaigorodsky Lorena , Rodríguez‐Pinto Claudia , Salas Wilbaldo , Muñoz Yamile , Betanco Bianca , Angulo Oscar , Huamán Marina , Lejbusiewicz Gladys , Pedrero Victor , Pavlova Milena , Groot Wim , Ibla Juan C. 
Published: March 2024

AbstractBackgroundMortality from congenital heart disease has decreased considerably in the last two decades due to improvements in overall health care. However, there are barriers to access to healthcare in Latin America for this population, which could be related to factors such as healthcare system, policies, resources, geographic, cultural, educational, and psychological factors. Understanding the barriers to access to care is of paramount importance for the design and implementation of policies and facilitate the provision of care.AimThe aim of the study was to investigate the perception of barriers to access to health care on parents/guardians of children with congenital heart disease in selected Latin American countries.MethodsA descriptive, cross‐sectional study, in which parents/guardians or primary caregivers of children with congenital heart disease was recruited to participate and surveyed. Once the informed consent process had been completed, a set of paper‐based scales was used to collect data, namely socioeconomic and demographic information, the Barriers to Care for Children with Special Health Care Needs Questionnaire, and the General Health Questionnaire.ResultsIn total, 286 participants completed the surveys, with an average age of 34.81 years and 73.4% being female. Mean score of overall barriers was 54.45 (minimum score 39, maximum score 195, higher scores show greater perception of barriers). In Mexico, the parents/guardians of children perceived fewer barriers to access (46.69), while Peru is the country where the most barriers were perceived (69.91). Nonpoor participants showed higher overall barrier perception scores (57.34) than poor participants (52.58). The regression analysis demonstrated the overall perception of barriers was positively associated with individual and social factors, such as educational level, contract status, household monthly income, and psychological well‐being and with the country of the participants.ConclusionsMultiple factors are associated with the perception of barriers to accessing health care for children with congenital heart disease, including socioeconomic status, expectations, psychological well‐being, and structural factors.
Exposure to heat wave risks across time and places: Seasonal variations and predictors of feelings of threat across heat wave geographical susceptibility locations
Authors: Domingos Samuel , Gaspar Rui , Marôco João 
Published: March 2024

AbstractVulnerability to heat waves and their negative effects on health vary not only due to individual factors but also due to situational factors, such as time and geography. Hence, we explored seasonal variations and predictors of heat wave feelings of threat across different heat wave geographical susceptibility locations in Portugal. A total of 238 Portuguese residents responded to a web‐based longitudinal survey: before the summer, during a heat wave in the summer, during the summer, and after the summer. Geographical location was used as an indicator of risk exposure, operationalized as heat wave occurrence susceptibility (low, moderate, high). Heat wave demands and resources perceptions were assessed to compute an indicator of heat wave feelings of threat. During the heat wave, feelings of threat were higher among participants in high‐susceptibility locations, with demands outweighing resources perceptions, suggesting greater distress and coping difficulty. Regression analysis suggested that older participants and female participants living in moderate–high‐susceptibility locations had greater difficulty in recovering. Heat wave risk perception and positive affect about heat were identified as the most consistent predictors of heat wave feelings of threat, with risk perception increasing and positive affect decreasing such feelings. Participants with (individual and geographical) vulnerability profiles, who had greater difficulty in coping and recovering from heat waves, could benefit from resource‐building/enhancing interventions. In a climatic crisis context, monitoring psychological responses to heat waves (e.g., threat) may enable anticipated action to build resilience before, rather than after, the effects become damaging to physical and psychological health.
What are filling (volumizing) threads?
Authors: Yi Kyu‐Ho 
Published: March 2024

AbstractFacial aging prompts a shift in the demands for lifting procedures, transitioning from targeted improvements in younger individuals to overall facial contour enhancements as skin elasticity declines in later years. This paper examines the evolution of PDO volumizing threads, delineating their development from initial limitations to contemporary innovations aimed at addressing tissue deformation and maintaining thread integrity post‐insertion. Categorizing these threads based on elasticity, shape, and functionality underscores their versatility and application nuances, catering to specific wrinkle correction, contour sculpting, and facial volume restoration. The discussion emphasizes the pivotal role of thread characteristics in achieving optimal outcomes while minimizing potential complications. By delving into historical contexts, mechanisms, effectiveness, and thread classification, this paper equips practitioners with a comprehensive understanding to make informed decisions in selecting threads for volumizing thread procedures. Recommendations for future research directions, including long‐term safety assessments and patient‐specific outcomes, seek to enhance the clinical utility and applicability of this analysis.
A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a BEST Collaborative study)
Authors: So‐Osman Cynthia , Delaney Meghan , Fung Mark , Lu Wen , Murphy Michael , Sasongko Praiseldy Langi , Tiberghien Pierre , Tinmouth Alan ,   the Best ImmunoGlobulin (BIG) Study Group* the Biomedical Excellence for Safer Transfusion Collaborative
Published: March 2024

AbstractBackgroundImmunoglobulin (IG) therapy is widely used to treat primary and secondary immune deficiencies and as immunomodulatory agent for various disorders. There is great concern that shortages of IG may rise, potentially affecting medical treatment options.Study Design and MethodsAn international survey was developed to study how intravenous immunoglobulins (IVIGs) are used and managed within hospitals in case of shortages. Study data were collected and managed using REDCap electronic data capture tools hosted by the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. The survey was directed to hospital pharmacists and blood bank transfusion professionals and disseminated through members of the BEST Collaborative network.ResultsSurvey respondents from institutions in the USA, Canada, Europe, Japan, and Australia (n = 13) confirmed that the primary specialties utilizing IG are neurology, hematology, and immunology. More than 60% of respondents reported IG supply shortages, but mitigation strategies were not well developed.DiscussionAs IG is the leading driver in plasma demand, more studies are needed to understand current and future demand for IG from the clinical perspective. Necessity lies in establishing clinical guidance to address shortages.
A novel measure to summarize blood transfusion practice during critical illness
Authors: Bosch Nicholas A. , Law Anica C. , Shi Zhan , Jafarzadeh S. Reza , Walkey Allan J. 
Published: March 2024

AbstractBackgroundLarge‐scale observational studies have summarized transfusion practice using traditional measures of central tendency (e.g., the mean hemoglobin concentration at the time of transfusion). However, the mean hemoglobin concentration fails to identify specific hemoglobin concentration thresholds that drive practice. In the following brief report, we propose a novel measure of “practice discontinuity” that identifies specific practice‐defining hemoglobin thresholds.Study Design and MethodsWe used the PINC AI Database (2016–2022) to identify adult patients admitted to an intensive care unit with at least one hemoglobin concentration measurement. For each day that hemoglobin was measured, we identified whether the patient received a red blood cell transfusion using hospital charge codes. We defined the “practice discontinuity” measure as the hemoglobin concentration at which there was the largest increase in transfusion use going from a higher to an incrementally lower hemoglobin concentration. We also calculated the mean and median pretransfusion hemoglobin concentrations.ResultsWe identified 1,298,367 patients and 4,905,839 patient‐days for inclusion. RBC transfusion occurred in a total of 530,654 (10.8%) patient‐days. The overall pre‐transfusion mean and median hemoglobin concentrations were 8.4 and 8.0 g/dL, respectively. The practice discontinuity measure identified 7.0 g/dL as the hemoglobin concentration at which transfusion use increased the most, from 46.6% of patient‐days at a concentration of 7.0 g/dL to 74.8% of patient‐days at a concentration of 6.9 g/dL.DiscussionWe propose that future studies of red blood cell transfusion practice consider inclusion of the practice discontinuity measure to more fully summarize clinical practice.
Design Principles and Restrictions for Continuous Fiber-Reinforced Additive Manufacturing
Authors: Heitkamp Tim , Hilbig Karl , Kuschmitz Sebastian , Girnth Simon , Waldt Nils , Klawitter Günter , Vietor Thomas 
Published: March 2024

Abstract
In the development of innovative and high-performance products, design expertise is a critical factor. Nevertheless, novel manufacturing processes often frequently lack an accessible comprehensive knowledge base for product developers. To tackle this deficiency in the context of emerging additive manufacturing processes, substantial design knowledge has already been established. However, novel additive manufacturing processes like continuous fiber-reinforced material extrusion have often been disregarded, complicating the process's wider dissemination. The importance of design knowledge availability is paramount, as well as the need for user-friendly design knowledge preparation, standardized structure, and methodological support for accessing the accumulated knowledge with precision. In this paper, we present an approach that provides formalized opportunistic and restrictive design knowledge, ensuring both the comprehensive exploitation of process-specific potentials and the consideration of restrictive limitations in the construction of components. Opportunistic knowledge, presented as principle cards, is systematically derived, prepared, and made accessible. Moreover, an access system is developed to ensure the comprehensive utilization of process-specific potentials throughout the development process. Furthermore, we propose linking these principles through a synergy and conflict matrix, aiming to consider synergistic principles and identify potential conflicts at an early stage. Additionally, an approach to provide restrictive design knowledge in the form of a design rule catalog is proposed. The application of the knowledge system is demonstrated exemplarily using a weight-optimized component.