bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gemtuzumab ozogamicin plus midostaurin in combination with standard ‘7 + 3’ induction therapy in newly diagnosed AML: Results from the SAL‐MODULE phase I study
Authors: Röllig Christoph , Schliemann Christoph , Ruhnke Leo , Fransecky Lars , Heydrich Björn‐Niklas , Hanoun Maher , Noppeney Richard , Schäfer‐Eckart Kerstin , Wendelin Knut , Mikesch Jan‐Henrik , Middeke Jan Moritz , Reimann Manja , Fiebig Frank , Zukunft Sven , Wermke Martin , Serve Hubert , Platzbecker Uwe , Müller‐Tidow Carsten , Baldus Claudia D. , Bornhäuser Martin 
Published: April 2024

SummaryWe conducted a phase I trial in newly diagnosed acute myeloid leukaemia (AML) to investigate the combination of two novel targeted agents, gemtuzumab ozogamicin (GO) and midostaurin, with intensive chemotherapy in FLT3‐mutated AML and CBF leukaemia. Three dose levels of midostaurin and one to three sequential doses of 3 mg/m2 GO in combination with ‘7 + 3’ induction were evaluated. Based on safety findings in 12 patients, our results show that 3 mg/m2 GO on Days 1 + 4 and 100 mg midostaurin on Days 8–21 can be safely combined with IC in newly diagnosed AML.
Unravelling the process of idea generation and assessment during the PhD trajectory: A case study approach
Authors: Gruber Marie , Crispeels Thomas 
Published: April 2024

AbstractThe three missions of universities are education, research, and knowledge/technology transfer. At the micro‐level of the research and knowledge/technology transfer mission, we position researchers, as individuals who decided to pursue a scientific career in academia, with the PhD as the starting point. While existing literature acknowledges the supervisor's significance during this process from dependency to autonomy, this paper advocates for a closer examination of external factors such as the network, supervisor's experience, and work environment in idea generation. Ideas in this context encompass both curiosity‐driven and entrepreneurial concepts, often evolving from one to the other. Our research builds upon the theory of opportunity identification, drawing parallels between ideas and opportunities. The research asserts that PhD students primarily rely on their networks for idea generation due to limited prior knowledge and experience. Our findings underscore the dynamic interplay between PhD students, supervisors, and networks in the process of idea generation, advancing a comprehensive framework encapsulating the multifaceted influences on the trajectory from idea generation to execution in the context of PhD education. The framework is based on empirical evidence from a qualitative case study comprising 16 PhD students in a European H2020 project in the field of Photonics, illuminating the intricate relationship between supervisors' orientations (entrepreneurial or curiosity‐driven) and the types of ideas generated by PhD students. Practical implications highlight the need for tailored support and resources to foster independent research capabilities among PhD students, considering individual variations in supervisory support and networking opportunities.
Experiences of people with Long Covid with a digital physiotherapy intervention: A qualitative study
Authors: Estebanez‐Pérez María‐José , Martín‐Valero Rocío , Pastora‐Estebanez Pablo , Pastora‐Bernal José‐Manuel 
Published: April 2024

AbstractPurposeLong Covid syndrome is a multiorgan condition with multiple sequelae affecting quality of life, capacity to work and daily activities. The advantages that new technologies can offer are presented as an opportunity in the current healthcare framework.ObjectiveThis research aimed to explore people with Long Covid's experiences with a digital physiotherapy practice intervention, during four weeks.MethodsQualitative semistructured interviews were conducted by video call. Thirty‐two Long Covid participants were invited to join an in‐depth interview once the intervention was completed. Participants were queried on their intervention experiences and perceptions, as well as any lifestyle changes made, as a result of receiving digital physiotherapy practice. The interviews were transcribed and analysed using inductive qualitative content analysis.ResultsIn‐depth qualitative analysis has revealed four themes that reflect participants' perceptions of digital physiotherapy intervention. The helpfulness of the exercises, interaction with the physiotherapist, the domestic use of technology and the future of digital health practice were the topics highlighted by Long Covid participants. Some improvements have been suggested including video sounds and the need to introduce face‐to‐face sessions. Participants stated that interventions were helpful and superior to printed exercise sheets, mobile phone apps and usual care received. This intervention did not present major barriers, highlighting the importance of personalized care and continuity in the provision of health services.ConclusionThe digital physiotherapy practice is perceived by people with Long Covid as an appropriate method for the care of their health needs. Participants stated the need for this type of intervention in the public health system, where it would eliminate waiting lists, facilitate accessibility and improve existing care.Patient and Public ContributionParticipants contributed to the interpretation of the data acquired in the interview.Clinical Trial RegistrationTrial registration NCT04742946.
Home nursing and self‐administered outpatient parenteral antimicrobial treatment: a comparison of demographics and outcomes from a large regional hospital in Queensland, Australia
Authors: Brand Holly , Fryer Michael , Mehdi Ahmed M. , Melon Alex , Morcombe Bridie , Choong Keat , Subedi Shradha 
Published: April 2024

AbstractBackgroundOutpatient parenteral antimicrobial treatment (OPAT) is a safe and effective therapy used in several settings across Australia. As OPAT services expand their inclusion criteria to include complex patient populations, there is an increased need for selecting appropriate patients to receive either healthcare‐administered OPAT (H‐OPAT) or self‐administered OPAT (S‐OPAT).AimsTo describe patient demographics, diagnosis, microbiology and outcomes of patients treated by H‐OPAT and S‐OPAT within the Sunshine Coast Hospital and Health Service, Australia.MethodsData on demographics, diagnoses, treatment and outcomes on all patients treated by H‐OPAT and S‐OPAT from March 2017 to December 2019 were collected retrospectively.ResultsOne hundred and sixty‐five patients (62.26%) were enrolled in H‐OPAT and 100 patients (37.74%) in S‐OPAT. S‐OPAT patients were significantly younger. H‐OPAT patients were more comorbid. Bone and joint infections were the most treated infections and were more likely to be treated by S‐OPAT. There was no difference in treatment duration, cure and complication rates between S‐OPAT and H‐OPAT. Longer duration of therapy was associated with more complications. Treatment failure was associated with infections due to multiple organisms, number of comorbidities and treatment of surgical site, skin and soft tissue infections.ConclusionsThere were significant differences in demographics between H‐OPAT and S‐OPAT without any difference in outcomes. Overall failure and complication rates were low. Higher rates of treatment failure were predicted by the diagnosis, number of comorbidities and number of organisms treated.
Are we practising what we preach and are we all singing from the same hymn sheet? An exploration of teaching in paediatric caries management across UK dental schools
Authors: Campbell Faith , Goldsmith Rachel , Rogers Helen 
Published: April 2024

AbstractBackgroundThe evidence underpinning caries management for children has progressed dramatically over the past 20 years. Anecdotally, this is not reflected in the teaching provided to undergraduate dental students, with the ongoing teaching of outdated methods within some dental schools.AimTo capture the current undergraduate teaching provision and clinical treatment experience requirement relative to caries management in paediatric dentistry in UK dental schools.DesignCross‐sectional analysis of current teaching methods on paediatric caries management was obtained using a piloted online data collection form. Question content included current caries teaching methods, assessment of student exposure and competence. The results were analysed descriptively.ResultsOf the 16 UK dental schools, 14 participated. Discrepancy in teaching content was apparent. Many schools (n = 9) taught biological caries management through therapeutic fissure sealants, yet this was not reflected in assessment and clinical requirements. Some schools (n = 4) taught amalgam placement in children, and most (n = 12) operatively taught treatments that would no longer be routinely provided in general dental practice in the UK, including primary tooth pulpotomy.ConclusionThere is substantial variation in the paediatric caries management techniques that are taught across UK dental schools, demonstrating a need for a national consensus to address these disparities.
Race matters more than racial identity disclosure when evaluating applicant diversity statements
Authors: Nguyen Fiona , Carroll Ellen M. , Atkinson Ciara , Walker Tammi D. , Croft Alyssa 
Published: April 2024

AbstractThe present research investigated whether a target applicant's race and disclosure of their race in a personal diversity statement influenced White evaluators' perceptions of the applicant's egalitarian motivations and their likelihood of contributing to organizational diversity and inclusion outcomes. In Study 1 (N = 206), participants evaluated a diversity statement that was ostensibly written by a White or Black applicant who either referenced or did not reference his race within the statement. Participants judged Black applicants as more internally motivated to be egalitarian and White applicants as more externally motivated, regardless of whether they disclosed their race in the statement. Participants also judged Black applicants as more likely to contribute to diversity and inclusion outcomes than White applicants. Study 2 (N = 257) aimed to replicate Study 1 and tested a strengthened race disclosure condition. We again saw little evidence of race disclosure impacting evaluations of applicants: Black applicants were judged as more internally motivated, less externally motivated, and more likely to contribute to diversity and inclusion compared to White applicants. Study 3 (N = 297) aimed to further replicate and expand on these results by testing a disclosure manipulation wherein the applicant discussed the personal importance/centrality of his race. Once again, applicant race (and not disclosure) demonstrated consistent effects on applicant evaluations. Our results highlight flaws in the personal diversity statement evaluation process, such that factors beyond statement content (i.e., applicant race) influenced perceptions and outcomes of the applicants. Practical implications and solutions for applicant evaluation processes are discussed.
Examining the efficacies of instructor‐designed instructional videos in flipped classrooms on student engagement and learning outcomes: An empirical study
Authors: Shen Yan 
Published: April 2024

AbstractBackgroundInstructional videos constitute a pivotal component in flipped learning. Despite their significance, there is a dearth of research specifically dedicated to instructional videos within the context of flipped classrooms. This paucity has led to an empirical void in verifying the efficacy of instructional videos in flipped learning environments.ObjectivesThe present study endeavours to contribute to the extant literature on flipped pedagogical practices by providing empirical evidence regarding the effectiveness of instructional videos in flipped learning environments.MethodsThis study employs a convergent mixed‐methods design. Forty‐five instructional videos in three subtypes were administered in two classes over a 15‐week semester. Data, both quantitative (log data from the learning management system) and qualitative (from focus group discussions at two time points), were concurrently collected from a flipped class (n = 25) and a blended class (n = 28) with the aim of gauging student engagement and learning outcomes in the flipped class and understanding video‐viewing features typical of the flipped class.ResultsBoth datasets corroborated that participants in the flipped class outperformed their counterparts in the blended class in terms of video‐watching, peer interaction, knowledge retention, and transfer skills.ConclusionsThe instructional videos within the flipped classroom setting serve to enhance student engagement in the learning process and improve learning outcomes. The efficacy of these instructional videos in flipped learning can be further augmented through strategic approaches in both their design and implementation.
Associations of fasting plasma glucose with all‐cause mortality and cardiovascular events in older Chinese diabetes patients: A population‐based cohort study
Authors: Wang Linan , Zhang Wei , Dai Juan , Deng Qing , Yan Yaqiong , Liu Qing 
Published: April 2024

AbstractAims/IntroductionOur aim was to investigate the optimal fasting glucose (FPG) range in Chinese older adults with type 2 diabetes, and to clarify whether the optimal range varies according to the control of risk factors.Materials and MethodsThe baseline survey for the cohort study began in 2018, with follow up ending in 2022. Our study enrolled 59,030 older diabetes patients with no history of cardiovascular disease (CVD). Participants were divided into nine groups based on their baseline glycemic status. The association between FPG and the risk of adverse outcomes was mainly estimated by multivariate Cox proportional risk models and restricted spline analysis.ResultsDuring the 4‐year follow‐up period, a total of 5,637 deaths and 4,904 CVD events occurred. The associations of FPG with mortality and CVD events showed J‐shaped curves. Among all‐cause deaths, the hazard ratios for FPG ≤4.50 and >11.50 mmol/L were 1.50 (95% confidence interval [CI] 1.31–1.71) and 1.84 (95% CI 1.67–2.02). Among CVD, the hazard ratios for FPG ≤4.50 and >11.50 mmol/L were 1.31 (95% CI 1.13–1.53) and 1.71 (95% CI 1.54–1.89), respectively. The optimal FPG ranges of all‐cause mortality and CVD were 5.50–7.50 and 4.50–7.50 mmol/L, respectively. For participants with at least two risk factors, the optimal FPG levels were higher than those with fewer risk factors.ConclusionsIn older Chinese diabetes patients, the FPG ranges related to the minimum death and CVD event rates were 5.50–7.50 and 4.50–7.50 mmol/L, respectively. Patients with more cardiovascular risk factors had higher optimal blood glucose ranges than those with fewer risk factors.
Immediate loading on two adjacent single dental implants with definitive nonsplinted restorations: A proof of concept in the posterior zone
Authors: Park Jin‐Young , Strauss Franz‐Josef , Schiavon Lucia , Patrizi Andrea , Cha Jae‐Kook , Lee Jung‐Seok , Jung Ronald , Jung Ui‐Won , Thoma Daniel 
Published: April 2024

AbstractObjectivesTo evaluate clinical, clinician‐ and patient‐reported outcomes (PROs) of two adjacent single posterior implants immediately loaded with definitive single crowns up to 1 year. Ten patients in need of two adjacent posterior single implants were included. All implants were placed applying a fully digital workflow. Definitive screw‐retained single zirconia crowns were delivered within 72 h after implant placement. Clinical parameters, patient‐ and clinician‐reported outcomes were assessed up to 1 year of follow‐up.Clinical ConsiderationsClinical outcomes remained stable, with no implant failures or technical and biological complications throughout the observation period. Patient satisfaction was very high at baseline (crown delivery) and remained consistently high at 6 and 12 months of follow‐up. Crown insertion 3 days after implant placement was rated as an easy procedure by clinicians.ConclusionsTwo adjacent single implants with immediate definitive restorations (<72 h) in the posterior region appear to be a viable and easy treatment option to shorten the overall treatment time and potentially enhancing patient satisfaction. However, randomized controlled trials are needed to confirm the advantages of this treatment protocol over a delayed loading approach.Clinical SignificanceIn selected cases, immediate implant loading with definitive restorations in the posterior region appears a valuable and straightforward option to shorten the overall treatment time.
Housework among same‐sex and different‐sex couples: The roles of time and earnings
Authors: Fischer Jocelyn 
Published: April 2024

AbstractObjectiveThis study examined how paid work time and earnings are related to time spent in various types of housework tasks among people in same‐sex couples (SSCs) and how these relationships differ from those among people in different‐sex couples (DSCs).BackgroundPrior research on housework among people in SSCs mostly relied on convenience samples and self‐report measures of housework. These methods may have drawbacks related to the selectivity of the samples and the accuracy of the housework measures. Specifically, SSCs might try to portray their housework divisions as more equal than they actually are.MethodThe current study used nationally representative, time diary data from the American Time Use Survey (N = 50,899) to estimate the relationships between paid work time, earnings, and time spent in various types of housework tasks (feminine, masculine, and gender‐neutral tasks) among people in SSCs and DSCs.ResultsPaid work time was related to housework time among both men and women in SSCs, but earnings were only related to housework among men in SSCs. Furthermore, some associations between paid work characteristics and housework were stronger among men in SSCs compared with men in DSCs. Among women, the pattern of couple‐type differences in the associations of interest was more nuanced.ConclusionUsing high‐quality, nationally representative data, the results point to a greater level of specialization of paid work and housework responsibilities among people in SSCs relative to people in DSCs than has previously been observed in the bulk of the literature.
The asymmetric effects of improving and declining marital satisfaction on cognitive function
Authors: Kim Jinho , Hwang Sungsik 
Published: April 2024

AbstractObjectiveThis study examines the association between marital satisfaction and cognitive function, while distinguishing between the effects of improving and declining marital satisfaction. Moreover, potential differences in these asymmetric effects of marital satisfaction between middle‐aged and older adults are explored.BackgroundMarital satisfaction is known to promote cognitive function. However, previous studies have assumed that the effects of improving and declining marital satisfaction are symmetrical.MethodUsing seven waves of data from the Korean Longitudinal Study of Aging 2006–2018 (N = 7407), we employ a novel asymmetric fixed effects model to estimate the effects of improving and declining marital satisfaction separately. Stratified analyses were conducted by age group and gender.ResultsThe association between declining marital satisfaction and cognitive function (b = −0.292, p < .001) was stronger than the association between improving marital satisfaction and cognitive function (b = 0.102, p < .001). These asymmetric effects were predominantly driven by older adults. The effect of declining marital satisfaction on cognitive function was significantly greater for older adults than middle‐aged adults (−0.395 vs. −0.148). We did not find gender differences.ConclusionFindings suggest that the negative impact of declining marital satisfaction on cognitive function outweighs the positive effects of improving marital satisfaction, especially among older adults. Reducing marital dissatisfaction and fostering healthy marital relationships are crucial strategies to promote the cognitive well‐being of older adults.
Effects of altering diet carbohydrate profile and physical form on zoo‐housed giraffe Giraffa camelopardalis reticulata
Authors: Kearney Celeste C. , Ball Ray L. , Hall Mary Beth 
Published: April 2024

AbstractUnlike wild giraffe that primarily consume low starch browse, the preference of zoo‐housed giraffe for consuming supplemental feeds over forage could increase the risk of digestive disorders such as ruminal acidosis. Our objective was to evaluate the effects of modifying a supplemental feed's non‐fibre carbohydrate profile and physical form on nutritional, behavioural, and blood measures of giraffe in a zoological setting. Six non‐lactating, adult, female reticulated giraffes were used in a two‐pen modified reversal study using two dietary treatments in seven 21‐day periods with data collected on days 15–21. Dietary treatments were a control feed comprised of commercially available products used at the time as the giraffe feed (GF) and an unpelleted experimental feed (EF). On a dry matter basis, GF and EF, respectively, contained 17.0% and 17.4% crude protein, 14.2% and 1.5% starch, 14.9% and 21.3% ethanol‐soluble carbohydrates, 22.9% and 26.0% acid detergent fibre (ADF) and 9.50% and 14.9% ND‐soluble fibre (NDSF), with modulus of fineness values of 3.62 and 4.82. Supplemental feeds, alfalfa hay, salt, and water were available for ad libitum consumption. Significance was declared at p ≤ 0.05. Intakes of hay, supplemental feeds, and total feed did not differ by diet (p > 0.28), though intakes of starch (0.93 and 0.12 kg; p = 0.05) and ADF (1.83 and 2.23 kg; p = 0.04) differed between GF and EF respectively. Giraffe behaviour values (min/48 h) were greater with EF for total eating (p = 0.04); diets were not detected as different for engagement in oral stereotypes (GF = 433, EF = 318 min/48 h; p = 0.22). Blood glucose was higher on GF than EF (99.0 and 82.3 mg/dL; p = 0.03). The lower EF blood glucose value is more similar to ranges reported for domesticated ruminants. No differences were detected for changes in body weight or body condition score in the 21‐day periods (p > 0.32). Modification of supplemental feed carbohydrate profile and physical form can influence behaviour and blood glucose values of zoo‐housed giraffe.