bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enamel Matrix Derivative Exhibits Anti‐Inflammatory Properties in Monocytes
Authors: Sato Sunao , Kitagawa Masae , Sakamoto Kiyako , Iizuka Shinji , Kudo Yasusei , Ogawa Ikuko , Miyauchi Mutsumi , Chu Emily Y. , Foster Brian L. , Somerman Martha J. , Takata Takashi 
Published: March 2008

Background: Enamel matrix derivative (EMD) is used clinically to promote periodontal tissue regeneration with variable efficacy. EMD application results in significantly higher frequencies of sites without clinical signs of inflammation; additionally, patients receiving EMD therapy report significantly less post‐treatment discomfort. However, there are few reports that focus on defining the biologic mechanisms for the observed anti‐inflammatory effects of EMD. The aim of this study was to evaluate the influence of EMD on inflammatory‐associated markers using an in vitro monocyte assay.Methods: Rat monocytes were exposed to lipopolysaccharide (LPS; 100 ng/ml from Escherichia coli or Actinobacillus actinomycetemcomitans) along with EMD (0, 50, 100, or 200 μg/ml). Levels of tumor necrosis factor‐alpha (TNF‐α) and prostaglandin E2 (PGE2) in conditioned media were analyzed by enzyme‐linked immunosorbent assay. In addition, the effects of exogenous PGE2 on TNF‐α production from LPS‐stimulated monocytes were determined.Results: LPS‐stimulated monocytes exposed to EMD exhibited a decrease in TNF‐α production (0.10‐ to 0.52‐fold) and an increase in PGE2 production (1.31‐ to 2.71‐fold) compared to controls not treated with EMD. Exogenously applied PGE2 decreased TNF‐α production by LPS‐stimulated monocytes in a dose‐dependent manner, and EMD treatment enhanced this PGE2‐mediated inhibition of TNF‐α production.Conclusion: In addition to EMD's published role in inducing proliferation, migration, adhesion, mineralization, and differentiation of periodontal ligament cells, our results indicated that EMD modulates two inflammation‐associated factors, TNF‐α and PGE2, in monocytes.
Concentration of radiation displacement defects in BSO and BGO crystals irradiated by electrons or neutrons
Authors: Potera Piotr 
Published: March 2008

Abstract
This work is devoted to the calculation of the concentration of radiation displacement defects (RDD) in bismuth germanate and bismuth silicate crystals as a function of particle energy (electrons and neutrons). Energy dependencies of RDD concentrations are discussed in comparison with results for other complex oxide crystals. The obtained results show that for the case of electron irradiation the radiation hardness of BSO and BGO should be similar to other oxide crystals, but for neutrons is drastically smaller. Additionally, for the neutron irradiation, the efficiency of the production of defects in the oxide sublattice is drastically smaller than for other oxide crystals.
Structural and elastic properties of barium chalcogenides (BaX, X=O, Se, Te) under high pressure
Authors: Bhardwaj Purvee , Singh Sadhna , Gaur Neeraj 
Published: March 2008

Abstract
In the present paper we have investigated the high-pressure, structural phase transition of Barium chalcogenides (BaO, BaSe and BaTe) using a three-body interaction potential (MTBIP) approach, modified by incorporating covalency effects. Phase transition pressures are associated with a sudden collapse in volume. The phase transition pressures and associated volume collapses obtained from TBIP show a reasonably good agreement with experimental data. Here, the transition pressure, NaCl-CsCl structure increases with decreasing cation-to-anion radii ratio. In addition, the elastic constants and their combinations with pressure are also reported. It is found that TBP incorporating a covalency effect may predict the phase transition pressure, the elastic constants and the pressure derivatives of other chalcogenides as well.
Information dynamics: temporal behavior of uncertainty measures
Authors: Garbaczewski Piotr 
Published: March 2008

Abstract
We carry out a systematic study of uncertainty measures that are generic to dynamical processes of varied origins, provided they induce suitable continuous probability distributions. The major technical tools are the information theory methods and inequalities satisfied by Fisher and Shannon information measures. We focus on the compatibility of these inequalities with the prescribed (deterministic, random or quantum) temporal behavior of pertinent probability densities.
The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research
Authors: Ostrowska Halina 
Published: March 2008

AbstractThe ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-κB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the pathogenesis of many human diseases, so both the ubiquitin-conjugating system and the 20S proteasome are important targets for drug discovery. This article presents a few of the most important examples of the small molecule inhibitors and modulators targeting the ubiquitin-proteasome system, their mode of action, and their potential therapeutic relevance in the treatment of cancer and inflammatory-related diseases.
Wild carnivores as source of zoonotic helminths in north-eastern Italy
Authors: Cerbo A. , Manfredi M. , Bregoli M. , Milone N. , Cova M. 
Published: March 2008

Abstract
Two hundreds and sixty red foxes, eighteen badgers and eight stone martens from north-eastern Italy were examined for zoonotic parasites by SCT, with particular attention to Trichinella sp. and Echinococcus multilocularis. No adult worms of E. multilocularis were observed in the intestine of red foxes or mustelids. Out of 223 fox faecal samples analysed by a commercial CA-ELISA, 5.8 % was positive to Echinococcus coproantigens. Trichinella sp. was detected by digestion of muscle in 1.2 % of examined foxes (2/172), but not in mustelids (0/11). Toxocara canis, responsible for human toxocarosis, resulted to be common in fox population (48.5 %). This parasite was found both in young (53.3 % of cubs and 61.9 % of sub-adults) and in adult animals (42.7 %). Other zoonotic parasites as Uncinaria stenocephala (52.3 %) and Trichuris vulpis (0.4 %) were detected in fox populations.
A rare case of alveolar echinococcosis in a 14-year-old child
Authors: Kinčeková J. , Hrčková G. , Bober J. , Vrzgula A. , Szabadošová V. , Bohuš P. , Zachar M. 
Published: March 2008

Abstract
We report the case of a 14-year-old girl who suffered from headache, fatigue, caught and a fever with body temperature up to 40 °C for a week. The patient had abdominal enlargement and clinical examination showed the hepatomegaly +5 cm. In ELISA assays employing Em2+ antigen, high titres of specific IgG antibodies to Echinococcus multilocularis somatic antigens were found in the serum. Western blot analysis also indicated on presence of alveolar echinococcosis (AE). CT examination showed expansive foci in the right liver lobe and histological examinations of the biopsy after PAS staining confirmed the presence of alveolar echinococcosis. After 320 days of chemotherapy with albendazole, CT revealed progression of parasitic foci and new abscess lesions inside parasitic cysts were detected, with some parts being necrotic. The surgical removing of foci was performed as following — the laparotomic revision, the removal of the right liver lobe with dilatation, reconstruction of v. cavae cum prothesis PTFE in length 12 cm. Three months after the operation, the rest of the patient’s left liver lobe had grownup and compensated at least a part of the removed liver.
The influence of desiccation and UV radiation on the development and survival of free-living stages of cyathostomins under field and laboratory conditions
Authors: Langrová I. , Jankovská I. , Vadlejch J. , Libra M. , Lytvynets A. , Makovcová K. 
Published: March 2008

Abstract
The present work describing both laboratory and field experiments was performed to assess the effects of desiccation and UV radiation on the development and survival of free-living stages of equine cyathostomins.
Cyathostomin larvae in horse faeces did not develop to the infective stage when faecal humidity levels dropped below 23 %, nonetheless solitary preinfective larvae were still recovered after 151 days (humidity 19.5 %). The development to infective stage after remoistening occurred for the last time after 54 days following desiccation.
Preinfective stages are susceptible to the effects of the direct desiccation stage. The preinfective larvae were rapidly killed within one minute, the cyathostomin eggs within 5 hours. The numerous normal mobile infective larvae were encountered after 35 days of the desiccated period. The preinfective stage of cyathostomins also showed very little tolerance to direct sun radiation: most eggs were killed by the exposure within 3 hours and the preinfective larvae within 1 hour. The survival of infective larvae was, on the other hand, unaffected by sun radiation after 7 days (P < 0.05). However, desiccated infective larvae were then found to be susceptible to UV radiation, resulting in total mortalities after 5 days.
Helminth parasites of the pupfish Cyprinodon meeki (Pisces: Cyprinodontiformes), an endemic freshwater fish from North-Central Mexico
Authors: Martínez-Aquino A. , Aguilar-Aguilar R. 
Published: March 2008

Abstract
A total of 21 pupfish Cyprindon meeki was collected from the spring Abraham González, Durango, Mexico. Seven helminth taxa were recovered: Salsuginus angularis, Posthodiplostomum minimum, Clinostomum complanatum, Bothriocephalus acheilognathi, Cyclustera cf. ralli, Atactorhynchus duranguensis and Spiroxys sp. Among them, B. acheilognathi and A. duranguensis were the most frequent and abundant species. The remaining species were rare and found at low mean abundance. The observed species richness, individual parasite abundance, and diversity were low at component community and infracommunity levels. These features are in accordance with those recorded for other freshwater fish species in the Nearctic part of Mexico. Host feeding habits, along with its role as intermediate host, are suggested as the main factors in determining the helminth community structure in this fish species.
Occurrence of the root-knot nematode Meloidogyne arenaria on balm and in a mixed population with M. javanica on grapevine in Greece
Authors: Karanastasi E. , Conceição I. , Santos M. , Tzortzakakis E. , O. Abrantes I. 
Published: March 2008

Abstract
The root-knot nematode Meloidogyne arenaria was found in Greece infecting balm (Melissa officinalis L.) and grapevine (Vitis vinifera L.). The isolate from balm was M. arenaria while the one from grapevine was a mixture of M. arenaria and M. javanica (prevalent species). This is the first report of the M. arenaria species in the country in which identification was based on biochemical methods and its occurrence on balm is a new host record.
Susceptibility to Treatment-Resistant Depression Within Families
Authors: Cheng Chih-Ming , Chen Mu-Hong , Tsai Shih-Jen , Chang Wen-Han , Tsai Chia-Fen , Lin Wei-Chen , Bai Ya-Mei , Su Tung-Ping , Chen Tzeng-Ji , Li Cheng-Ta 
Published: April 2024

ImportanceAntidepressant responses and the phenotype of treatment-resistant depression (TRD) are believed to have a genetic basis. Genetic susceptibility between the TRD phenotype and other psychiatric disorders has also been established in previous genetic studies, but population-based cohort studies have not yet provided evidence to support these outcomes.ObjectiveTo estimate the TRD susceptibility and the susceptibility between TRD and other psychiatric disorders within families in a nationwide insurance cohort with extremely high coverage and comprehensive health care data.Design, Setting, and ParticipantsThis cohort study assessed data from the Taiwan national health insurance database across entire population (N = 26 554 001) between January 2003 and December 2017. Data analysis was performed from August 2021 to April 2023. TRD was defined as having experienced at least 3 distinct antidepressant treatments in the current episode, each with adequate dose and duration, based on the prescribing records. Then, we identified the first-degree relatives of individuals with TRD (n = 34 467). A 1:4 comparison group (n = 137 868) of first-degree relatives of individuals without TRD was arranged for the comparison group, matched by birth year, sex, and kinship.Main Outcomes and MeasuresModified Poisson regression analyses were performed and adjusted relative risks (aRRs) and 95% CIs were calculated for the risk of TRD, the risk of other major psychiatric disorders, and different causes of mortality.ResultsThis study included 172 335 participants (88 330 male and 84 005 female; mean [SD] age at beginning of follow-up, 22.9 [18.1] years). First-degree relatives of individuals with TRD had lower incomes, more physical comorbidities, higher suicide mortality, and increased risk of developing TRD (aRR, 9.16; 95% CI, 7.21-11.63) and higher risk of other psychiatric disorders than matched control individuals, including schizophrenia (aRR, 2.36; 95% CI, 2.10-2.65), bipolar disorder (aRR, 3.74; 95% CI, 3.39-4.13), major depressive disorder (aRR, 3.65; 95% CI, 3.44-3.87), attention-deficit/hyperactivity disorders (aRR, 2.38; 95% CI, 2.20-2.58), autism spectrum disorder (aRR, 2.26; 95% CI, 1.86-2.74), anxiety disorder (aRR, 2.71; 95% CI, 2.59-2.84), and obsessive-compulsive disorder (aRR, 3.14; 95% CI, 2.70-3.66). Sensitivity and subgroup analyses validated the robustness of the findings.Conclusions and RelevanceTo our knowledge, this study is the largest and perhaps first nationwide cohort study to demonstrate TRD phenotype transmission across families and coaggregation with other major psychiatric disorders. Patients with a family history of TRD had an increased risk of suicide mortality and tendency toward antidepressant resistance; therefore, more intensive treatments for depressive symptoms might be considered earlier, rather than antidepressant monotherapy.
Magneto‐Optical Interactions in Layered Magnets
Authors: Wu Jiang‐Bin , Wu Heng , Tan Ping‐Heng 
Published: April 2024

AbstractThe rapidly emerging field of 2D magnetic materials has garnered significant attention due to its fascinating physical properties and wide‐ranging potential applications. This review highlights the importance of magneto‐optical interactions as a crucial tool for both studying and modulating 2D magnets. It offers a comprehensive survey of current research concerning magneto‐optical interactions in 2D magnetic materials, encompassing the magneto‐optical Kerr effect, reflection magnetic circular dichroism, second‐harmonic generation, photoluminescence, inelastic light scattering, and time‐resolved spectroscopy. This review discusses how these techniques provide insights into the properties of 2D magnets, enabling exploration of magnetic phase transitions, lattice alterations, spin dynamics, as well as their responses to external fields. Moreover, it emphasizes the modulation of magnetic properties by photo‐stimulation and offers a brief outlook on this swiftly developing field.
Self‐Assembly Route to Perylene Diimide(PDI)‐Bridged Cyclophanes
Authors: Mayhugh Jacob T. , Moaven Shiva , Davis Willow A. , Johnson Darren W. 
Published: April 2024

AbstractThis work reports the synthesis and self‐assembly of perylene diimide (PDI)‐containing macrocycles designed for facile and high‐throughput production of shape‐persistent, macrocyclic organic electronic materials. Specifically, utilizing dynamic covalent chemistry (DCvC), this work showcases ditopic thiols can be utilized as building blocks toward 3D materials with defined porosity, low‐lying unoccupied molecular orbitals, and intrinsic fluorescence. The PDI disulfide‐linked macrocycles are generated in a single step from the thiolic building block to yield dimeric through pentameric assemblies in overall 95% combined yield; moreover, following self‐assembly, the disulfide ensemble is sulfur extruded to the more kinetically stable thioether in 79% combined yield. The modular design suggests these methods can be used to easily self‐assemble other electronically active precursors for utility in porous macrocyclic materials where stepwise pathways may be laborious and/or low yielding.
Unraveling Loss Mechanisms Arising from Energy‐Level Misalignment between Metal Halide Perovskites and Hole Transport Layers
Authors: Lee Jae Eun , Motti Silvia G. , Oliver Robert D. J. , Yan Siyu , Snaith Henry J. , Johnston Michael B. , Herz Laura M. 
Published: April 2024

AbstractMetal halide perovskites are promising light absorbers for multijunction photovoltaic applications because of their remarkable bandgap tunability, achieved through compositional mixing on the halide site. However, poor energy‐level alignment at the interface between wide‐bandgap mixed‐halide perovskites and charge‐extraction layers still causes significant losses in solar‐cell performance. Here, the origin of such losses is investigated, focusing on the energy‐level misalignment between the valence band maximum and the highest occupied molecular orbital (HOMO) for a commonly employed combination, FA0.83Cs0.17Pb(I1‐xBrx)3 with bromide content x ranging from 0 to 1, and poly[bis(4‐phenyl)(2,4,6‐trimethylphenyl)amine] (PTAA). A combination of time‐resolved photoluminescence spectroscopy and numerical modeling of charge‐carrier dynamics reveals that open‐circuit voltage (VOC) losses associated with a rising energy‐level misalignment derive from increasing accumulation of holes in the HOMO of PTAA, which then subsequently recombine non‐radiatively across the interface via interfacial defects. Simulations assuming an ideal choice of hole‐transport material to pair with FA0.83Cs0.17Pb(I1‐xBrx)3 show that such VOC losses originating from energy‐level misalignment can be reduced by up to 70 mV. These findings highlight the urgent need for tailored charge‐extraction materials exhibiting improved energy‐level alignment with wide‐bandgap mixed‐halide perovskites to enable solar cells with improved power conversion efficiencies.
Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation
Authors: Tian Yu , Jiang Fei , Xie Haijiao , Chi Zhe , Liu Chenguang 
Published: April 2024

AbstractBurns can cause severe damage to the skin due to bacterial infection and severe inflammation. Although conductive hydrogels as electroactive burn‐wound dressings achieve remarkable effects on accelerating wound healing, issues such as imbalance between their high conductivity and mechanical properties, easy dehydration, and low transparency must be addressed. Herein, a double‐network conductive eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide‐polymerization crosslink) and thiolated hyaluronic acid (disulfide‐bonding crosslink). The introduction of PDESs provides the eutectogel with a conductivity (up to 0.25 S·m−1) and mechanical strength (tensile strain of 59–77%) simulating those of natural human skin, as well as satisfactory tissue adhesiveness, self‐healing ability, and antibacterial properties. When combined with exogenous electrical stimulation, the conductive eutectogel exhibits the ability to reduce inflammation, stimulate cell proliferation and migration, promote collagen deposition and angiogenesis, and facilitate skin tissue remodeling. This conductive eutectogel shows great potential as a dressing for healing major burn wounds.
Development of an Injectable Biphasic Hyaluronic Acid‐Based Hydrogel With Stress Relaxation Properties for Cartilage Regeneration
Authors: Kim Han‐Sem , Li Cheng Ji , Park Sung‐Min , Kim Kyung Wook , Mo Ji‐Hun , Jin Guang‐Zhen , Lee Hae‐Hyoung , Kim Hae‐Won , Shin Ueon Sang , Lee Jung‐Hwan 
Published: April 2024

AbstractBiomimetic stress‐relaxing hydrogels with reversible crosslinks attract significant attention for stem cell tissue regeneration compared with elastic hydrogels. However, stress‐relaxing hyaluronic acid (HA)‐based hydrogels fabricated using conventional technologies lack stability, biocompatibility, and mechanical tunability. Here, it is aimed to address these challenges by incorporating calcium or phosphate components into the HA backbone, which allows reversible crosslinking of HA with alginate to form interpenetrating networks, offering stability and mechanical tunability for mimicking cartilage. Diverse stress‐relaxing hydrogels (τ1/2; SR50, 60–2000 s) are successfully prepared at ≈3 kPa stiffness with self‐healing and shear‐thinning abilities, favoring hydrogel injection. In vitro cell experiments with RNA sequencing analysis demonstrate that hydrogels tune chondrogenesis in a biphasic manner (hyaline or calcified) depending on the stress‐relaxation properties and phosphate components. In vivo studies confirm the potential for biphasic chondrogenesis. These results indicate that the proposed stress‐relaxing HA‐based hydrogel with biphasic chondrogenesis (hyaline or calcified) is a promising material for cartilage regeneration.
Photodetection Enhancement of PdSe2/ReSe2 Van der Waals Heterostructure Field‐Effect Transistors: A Density Functional Theory‐Guided Approach
Authors: Riaz Muhammad , Jaffery Syed Hassan Abbas , Abbas Zeesham , Hussain Muhammad , Suleman Muhammad , Hussain Sajjad , Aftab Sikandar , Seo Yongho , Jung Jongwan 
Published: April 2024

AbstractThe fabrication of van der Waals heterostructures (vdWHs) has drawn considerable interest because of their wide range of functionalities. Herein, a novel PdSe2/ReSe2 vdWHs with gate‐tunable rectification behavior and excellent broadband photodetection characteristics is presented. The application of the gate bias substantially enhances the rectification behavior, with the highest rectification ratio (≈3.13 × 103) observed at gate voltage Vg = −60 V. The density functional theory calculations demonstrate the direct and indirect bandgap behavior of PdSe2 and ReSe2 in the monolayer structure, respectively. Additionally, the PdSe2/ReSe2 heterojunction displays a strong photo‐response in the near‐infrared region and achieves a high photoresponsivity, an excellent external quantum efficiency, and rapid rise and decay times of 1.7 × 103 A W−1, 4.05 × 103, and 5 and 20 ms, respectively. Furthermore, the device exhibits a remarkable detectivity of ≈3.5 × 1012 Jones. The findings hold great potential for advancing the fabrication of multifunctional vdW heterostructure devices.
Fully Biodegradable Packaging Films for Fresh Food Storage Based on Oil‐Infused Bacterial Cellulose
Authors: Chen Guoli , Wang Kaimin , Chen Pinghang , Cai Daohang , Shao Yan , Xia Rui , Li Chun , Wang Haochuan , Ren Fuzeng , Cheng Xing , Yu Yanhao 
Published: April 2024

AbstractFully biodegradable packaging materials are demanded to resolve the issue of plastic pollution. However, the fresh food storage performance of biodegradable materials is generally much lower than that of plastics due to their high permeability, microbial friendliness, and limited stretchability and transparency. Here a biodegradable packaging material is reported with high fresh food storage performance based on an oil‐infused bacterial cellulose (OBC) porous film. The oil infusion significantly improved cellulose's food‐keeping performance by reducing its gas permeability, increasing its stretchability and transparency, and enabling the active release of green vapor‐phase preservative molecules, while maintaining its intrinsically high degradability. Strawberries stored in a container with the OBC lid at 23 °C after 5 days exhibited a moldy rate of 0%, in contrast to the 100% moldy rate of those stored by poly(ethylene). Enhanced storage performance is also obtained on tomatoes, pork, and shrimp. The OBC film is naturally degraded after being buried in wet soil at 30 °C for 9 days, identical to the degradation rate of bacterial cellulose. The liquid seal strategy broadly applies to different celluloses, providing a general option for developing cellulose‐based biodegradable packaging materials.