bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corrosion Fatigue Behavior of 6000 HP Fracture Pump of the Valve Body Under Different Plunger Stroke Times and Acid Fracture Fluid Environment
Authors: Wang Guorong , Wen Xinming , Hu Gang , Wang Mingcheng 
Published: February 2024

AbstractAs a key equipment for oil and gas extraction, the fracture pump is prone to failure due to fatigue crack in the crossbore of valve body. First, under acid fracture fluid and different loading frequencies, the fatigue crack growth rate of 17-4PH stainless steel was obtained by test, and the test data were used the modified Paris law. Then it is applied to numerical simulations to research the fatigue crack growth behavior of the valve body. The results show that the higher the loading frequency in the fracture fluid, the lower the fatigue crack growth rate, which is consistent with the test results. The influence of the working pressure on the stress intensity factor of the crack front is greater than that of the plunger stroke times. The model accurately predicts the fatigue crack orientation and corrosion fatigue crack growth life of the valve body.
Evaluation of fendiline treatment in VP40 system with nucleation-elongation process: a computational model of Ebola virus matrix protein assembly
Authors: Liu Xiao , Husby Monica , Stahelin Robert V. , Pienaar Elsje 
Published: February 2024

ABSTRACT

Ebola virus (EBOV) infection is threatening human health, especially in Central and West Africa. Limited clinical trials and the requirement of biosafety level-4 laboratories hinder experimental work to advance our understanding of EBOV and the evaluation of treatment. In this work, we use a computational model to study the assembly and budding process of EBOV and evaluate the effect of fendiline on these processes in the context of fluctuating host membrane lipid levels. Our results demonstrate for the first time that the assembly of VP40 filaments may follow the nucleation-elongation theory, as this mechanism is critical to maintaining a pool of VP40 dimers for the maturation and production of virus-like particles (VLPs). We further find that this nucleation-elongation process is likely influenced by fluctuating phosphatidylserine (PS), which can complicate the efficacy of lipid-targeted therapies like fendiline, a drug that lowers cellular PS levels. Our results indicate that fendiline-induced PS reduction may actually increase VLP production at earlier time points (24 h) and under low fendiline concentrations (≤2 µM). However, this effect is transient and does not change the conclusion that fendiline generally decreases VLP production. In the context of fluctuating PS levels, we also conclude that fendiline can be more efficient at the late stage of VLP budding relative to earlier phases. Combination therapy with a VLP budding step-targeted drug may therefore further increase the treatment efficiency of fendiline. Finally, we also show that fendiline-induced PS reduction more effectively lowers VLP production when VP40 expression is high. Taken together, our results provide critical quantitative information on how fluctuating lipid levels (PS) affect EBOV assembly and egress and how this mechanism can be disrupted by lipid-targeting molecules like fendiline.

IMPORTANCE
Ebola virus (EBOV) infection can cause deadly hemorrhagic fever, which has a mortality rate of ~50%–90% without treatment. The recent outbreaks in Uganda and the Democratic Republic of the Congo illustrate its threat to human health. Though two antibody-based treatments were approved, mortality rates in the last outbreak were still higher than 30%. This can partly be due to the requirement of advanced medical facilities for current treatments. As a result, it is very important to develop and evaluate new therapies for EBOV infection, especially those that can be easily applied in the developing world. The significance of our research is that we evaluate the potential of lipid-targeted treatments in reducing EBOV assembly and egress. We achieved this goal using the VP40 system combined with a computational approach, which both saves time and lowers cost compared to traditional experimental studies and provides innovative new tools to study viral protein dynamics.
Summer warming during Heinrich Stadial 1 in Northeast China
Authors: Zhu Zeyang , Wu Jing , Chu Guoqiang , Rioual Patrick , Lu Jiaxin , Wang Luo , Liu Jiaqi 
Published: February 2024

Abstract
The last deglaciation is considered a key period for exploring the underlying dynamics of temperature changes because it was characterized by multiple millennial-scale abrupt climatic events. However, the limited number of quantitative temperature records in Northeast (NE) China covering the last deglaciation hampers a complete understanding of the mechanisms and processes behind the temperature changes that occurred in that region. Here, we present a quantitative reconstruction of summer temperature over the last deglaciation based on bacterial branched glycerol dialkyl glycerol tetraethers (brGDGTs) analyzed from the sediment sequence of Lake Kielguo, a small volcanic lake in NE China. The results show that summer temperature was lowest during the interval ca. 20–18.2 calibrated (cal.) k.y. B.P. with a value of ~11.1 °C and increased by ~1.9 °C during Heinrich Stadial 1 (HS1) and by ~2.7 °C during the transition to the Bølling-Allerød (B-A). The summer temperatures during the B-A warm interval and Younger Dryas cold interval were ~14.1 °C and ~12.0 °C, respectively. The summer temperature record from the Lake Kielguo sediment sequence indicates that summer warming dominated the climate change state during HS1 in East Asia, which is different from the cooling pattern controlled by winter temperatures in the North Atlantic and Greenland realms. This distinction can be explained by weakened winter cooling signals triggered by the collapse of Atlantic Meridional Overturning Circulation when these signals propagated to East Asia, and increased summer temperature warming controlled by orbital and greenhouse gases during HS1 in East Asia.
Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant
Authors: van den Bosch Jacqueline J O N , Pennisi Vincenzo , Rao Harsha Laxmana , Mansouri Kaweh , Weinreb Robert , Thieme Hagen , Hoffmann Michael B , Choritz Lars 
Published: February 2024

Background
Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric IOP monitoring.

Methods
Seven primary patients with open-angle glaucoma previously implanted with a telemetric IOP sensor in one eye underwent automatic measurements throughout 24 hours on two consecutive days (‘day 1’ and ‘day 2’). Patients wore an antenna adjacent to the study eye connected to a reader device to record IOP every 5 min. Also, self-measurements in six of seven patients were collected for a period of 30 days. Analysis included calculation of hourly averages to correlate time-pairs of day 1 versus day 2 and the self-measurements vers day 2.

Results
The number of IOP measurements per patient ranged between 151 and 268 on day 1, 175 and 268 on day 2 and 19 and 1236 during 30 days of self-measurements. IOP time-pairs of automatic measurements on day 1 and day 2 were significantly correlated at the group level (R=0.83, p<0.001) and in four individual patients (1, 2, 6 and 7). IOP time-pairs of self-measurements and day 2 were significantly correlated at the group level (R=0.4, p<0.001) and in four individual patients (2, 5, 6 and 7).

Conclusions
Twenty-four hour automatic measurements of IOP are correlated on consecutive days and, though to a lesser degree, with self-measurements. Therefore a virtual 24-hour IOP curve might be constructed from self-measurements. Both options provide an alternative to frequent in-office IOP measurements.
Moving from ethnic exclusions to cultural safety: how is athlete ethnicity discussed in research on menstrual health in sports? A scoping review
Authors: Gibbons Agatha Elizabeth , Pedlar Charles , Varner Hemi Keakaokawai , Bruinvels Georgie , Hamilton Bruce , Thorpe Holly 
Published: February 2024

ObjectiveThis study aims to investigate how athlete ethnicity is discussed in the inclusion and exclusion criteria, methodology, findings, and conclusions of research focused on menstrual health in sports science and medicine.DesignA scoping review of sports-based research conducted on athletes related to (1) menstrual health and ethnicity, (2) how researchers include/exclude participants based on ethnicity and (3) how ethnicity is discussed.Data sourcesElectronic search of PubMed and ProQuest.Eligibility criteriaArticles were included if they met the following criteria: (1) published before September 2023, (2) published in peer-reviewed journals, (3) participants were women athletes, (4) published in English and (5) relating to menstrual health. Articles were assessed as good, fair or poor quality using the Inclusion of Participant Ethnicity Quality Assessment Criteria.ResultsFrom the 1089 studies available from the initial database search, 55 studies considered ethnicity. Nine studies met the inclusion criteria and were assessed as either good (22%), fair (44%) or poor (33%) in quality in their consideration of athlete ethnicity. 81% of research articles on menstrual health in sports do not consider athlete ethnicity, and when ethnicity is discussed, it rarely meets the criteria for cultural safety in the research process. Most studies did not factor ethnicity into the analysis and lacked cultural considerations in the research design and interventions.ConclusionMore careful inclusion of ethnicity in sports menstrual health-related research and recognition of social and cultural influences on health and research outcomes for indigenous and other ethnic minority groups is needed. Such research is required to support coaches, medical personnel and support staff in designing culturally safe environments for sportswomen from diverse cultural and ethnic backgrounds.
Management of chronic pancreatitis
Authors: Hines O Joe , Pandol Stephen J 
Published: February 2024

ABSTRACTChronic pancreatitis results from repeated episodes of pancreatic inflammation and associated fibrosis leading to the loss of functional exocrine and endocrine pancreatic function. The disease is manifested by abdominal pain, deterioration in quality of life, food maldigestion and malabsorption, diabetes, and an increased risk for pancreatic adenocarcinoma. This review summarizes the latest evidence on the diagnosis and management of chronic pancreatitis and its manifestations. In particular, this review discusses advances in understanding of the role of genetic disorders in the mechanisms of the disease and surgical options for patients refractory to medical therapy. Furthermore, clinical trials are under way to develop medical therapeutics.
Can we develop consensus on long-term follow-up and surveillance of primary shoulder arthroplasty? A study protocol using a real-time Delphi technique among expert clinicians in the UK
Authors: Morris Daniel , Bateman Marcus , Rangan Amar , Watts Adam , Tambe Amol 
Published: February 2024

BackgroundShoulder arthroplasty incidence is projected to continue its exponential growth and the resultant burden of monitoring patients with shoulder arthroplasty implants creates significant pressure on orthopaedic services. Surveillance offers the opportunity to study implant longevity, detect failing implants and potentially perform revision at lower morbidity and cost. There is a paucity of evidence to support recommendations on long-term follow-up in shoulder arthroplasty. Prospective studies comparing long-term follow-up and structure are impractical from time, resource and cost perspectives. A real-time Delphi technique represents a mechanism by which experts involved in long-term follow-up of primary shoulder arthroplasty can formulate recommendations via a transparent, reproducible and efficient process. We outline the protocol for a real-time Delphi study seeking consensus on long-term follow-up and surveillance of primary shoulder arthroplasty .MethodsA real-time Delphi technique will be used. A planning committee will design the Delphi statements. A steering committee will supervise and monitor the real-time Delphi process. Participants will be asked to rate their agreement with statements using a 5-point Likert scale. The Delphi statements will be derived from review of published literature, and the strength of evidence available for each statement will be provided. We will offer participation to all surgeons and extended-scope practitioners who are current members of the British Elbow & Shoulder Society (BESS) and have clinical practice involving shoulder arthroplasty follow-up. The questionnaire will be active for 4 weeks and requires a minimum of 20 participants. Consensus agreement is defined as 70% of participants selecting at least a 4-point on a 5-point Likert scale.DiscussionWe anticipate the outlined study will achieve consensus on long-term follow-up and surveillance of primary shoulder arthroplasty. We intend to use the expert consensus recommendations achieved, in addition to the limited applicable published evidence available, to produce BESS-affiliated guidelines on long-term follow-up and surveillance of primary shoulder arthroplasty.EthicsEthical approval is not required for the real-time Delphi study.We expect the results of this initiative will be published in a peer-reviewed, high-impact journal.
Heavy quarks in polarised deep-inelastic scattering at the electron-ion collider
Authors: Hekhorn Felix , Magni Giacomo , Nocera Emanuele R. , Rabemananjara Tanjona R. , Rojo Juan , Schaus Adrianne , Stegeman Roy 
Published: February 2024

AbstractWe extend the FONLL general-mass variable-flavour-number scheme to the case of longitudinally polarised DIS structure functions, accounting for perturbative corrections up to $$\mathcal {O}\left( \alpha _s^2\right) $$

O

α
s
2

. We quantify the impact of charm quark mass and higher-order perturbative corrections on projected measurements of inclusive and charm-tagged longitudinal asymmetries at the Electron-Ion Collider (EIC) and at the Electron-ion collider in China (EicC). We demonstrate how the inclusion of these corrections is essential to compute predictions with an accuracy that matches the projected precision of the measurements. The computation is made publicly available through the open-source EKO and YADISM programs.
Spatial sensitivity to absorption changes for various near-infrared spectroscopy methods: A compendium review
Authors: Blaney Giles , Sassaroli Angelo , Fantini Sergio 
Published: February 2024

This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media, particularly for measurements relevant to near-infrared spectroscopy. The three temporal domains, continuous wave, frequency domain, and time domain, each obtain different optical data types whose changes may be related to effective homogeneous changes in the absorption coefficient. Sensitivity is the relationship between a localized perturbation and the recovered effective homogeneous absorption change. Therefore, spatial sensitivity maps representing the perturbation location can be generated for the numerous optical data types in the three temporal domains. The review first presents a history of the past 30 years of work investigating this sensitivity in optically diffuse media. These works are experimental and theoretical, presenting one-, two-, and three-dimensional sensitivity maps for different Near-Infrared Spectroscopy methods, domains, and data types. Following this history, we present a compendium of sensitivity maps organized by temporal domain and then data type. This compendium provides a valuable tool to compare the spatial sensitivity of various measurement methods and parameters in one document. Methods for one to generate these maps are provided in Appendix A , including the code. This historical review and comprehensive sensitivity map compendium provides a single source researchers may use to visualize, investigate, compare, and generate sensitivity to localized absorption change maps.
Breast Cancer Stage and Size Detected with Film versus Digital Mammography in New South Wales, Australia: A Population-Based Study Using Routinely Collected Data
Authors: Farber Rachel , Houssami Nehmat , McGeechan Kevin , Barratt Alexandra , Bell Katy J.L. 
Published: February 2024

Abstract

Background:
Digital mammography has replaced film mammography in breast-screening programs globally, including Australia. This led to an increase in the rate of detection, but whether there was increased detection of clinically important cancers is uncertain.

Methods:
In this population-wide retrospective cohort study in New South Wales, Australia spanning 2004 to 2016 and including 4,631,656 screens, there were 22,965 cancers in women screened with film (n = 11,040) or digital mammography (n = 11,925). We examined the change in tumor characteristics overall and how these rates changed over time, accounting for changes in background rates using an interrupted time-series. Comparisons were made with unscreened women (n = 26,326) during this time.

Results:
We found increased detection of in situ cancer (3.36 per 10,000 screens), localized invasive, and smaller-sized breast cancers attributable to the change in mammography technology, whereas screen-detected intermediate-sized and metastatic breast cancers decreased. Rates of early-stage and intermediate-sized interval cancers increased, and late-stage (−1.62 per 10,000 screens) and large interval cancers decreased. In unscreened women, there were small increases in the temporal trends of cancers across all stages.

Conclusions:
At least some of the increased detection of smaller early-stage cancers may have translated into a reduction in larger and late-stage cancers, indicating beneficial detection of cancers that would have otherwise progressed. However, the increased detection of smaller early-stage and small cancers may also have increased over-diagnosis of lesions that would otherwise have not caused harm.

Impact:
Robust evaluation of potential benefits and harms is needed after changes to screening programs.
See related In the Spotlight, p. 638
The Accuracy and Precision of Memory for Natural Scenes: A Walk in the Park
Authors: Westebbe Leo , Liang Yibiao , Blaser Erik 
Published: February 2024

Abstract
It is challenging to quantify the accuracy and precision of scene memory because it is unclear what ‘space’ scenes occupy (how can we quantify error when misremembering a natural scene?). To address this, we exploited the ecologically valid, metric space in which scenes occur and are represented: routes. In a delayed estimation task, participants briefly saw a target scene drawn from a video of an outdoor ‘route loop’, then used a continuous report wheel of the route to pinpoint the scene. Accuracy was high and unbiased, indicating there was no net boundary extension/contraction. Interestingly, precision was higher for routes that were more self-similar (as characterized by the half-life, in meters, of a route’s Multiscale Structural Similarity index), consistent with previous work finding a ‘similarity advantage’ where memory precision is regulated according to task demands. Overall, scenes were remembered to within a few meters of their actual location.
The Scaling-up of Agricultural Mechanization Services and the Re-shaping of Small-Scale Household Farming in China
Authors: Chen Yiyuan 
Published: February 2024

Abstract
Taking the case of the agricultural mechanization service industry as an example, this study discusses the dynamics of the transformation of China’s agricultural contracting service industry in the context of the scaling-up of agricultural production, and how the transformation is reshaping small-scale household farming in grain production. With the accelerated growth of farmland transfer, large-scale agricultural producers have been emerging rapidly in different parts of China in the past years. Since their demand for agricultural contracting services is different from that of small-scale household producers, the scaling-up of agricultural production has promoted the scaling-up of agricultural contracting services. Meanwhile, the capital surplus in the agricultural machinery manufacturing industry has created three consequences simultaneously: the excess supply of agricultural mechanization services, the acceleration of agricultural machinery renewal, and the rising cost of machinery purchases. The interactions of these three factors not only raised the threshold of the agricultural machinery service industry, which makes it difficult for part-time service providers to survive market competition, but also shortened the time window for machinery service provision, which makes it difficult for large-scale agricultural producers to balance land operation and machinery service provision. Consequently, large-scale agricultural machinery service organizations are continuously replacing those small-scale part-time service providers. During this process, small-scale household producers engaged in grain production are faced with increasing risks of being excluded from farming, both directly and indirectly, as it is difficult for small producers to deal with large service organizations, and the small-scale part-time service providers that used to serve them are continually being replaced.
Smallholders in Capitalist Agriculture: Persistence and Challenges
Authors: Zhang Qian Forrest 
Published: February 2024

Abstract
This paper posits that the majority of “smallholders” in contemporary China are commodity producers who must engage in various commodity exchanges to carry out agricultural production and accomplish their social reproduction. Consequently, “smallholder” refers to a family-based economic operation model, rather than a social identity or psychological identification. Within this framework, the study focuses on the intricate relationships between smallholders, various commodity markets, and other market participants. Specifically, it examines two aspects: the relationship between smallholders and capitalized large-scale producers and other agriculture-related capital entities, and the relationship between smallholders and the commodified labor force. The paper argues that the interaction between smallholders and capitalized large-scale producers is not a zero-sum game of mutual replacement; except in certain areas, smallholders are not driven out of agricultural production by large-scale capitalized producers, but coexist and interact with them in various ways. On the other hand, smallholders heavily rely on short-term hired labor for their agricultural production, and many also become wage earners themselves, participating in the agricultural production of other producers and earning wage income. Compared to the expansion of capitalized large-scale production, the most significant challenge facing China’s smallholder economy, as this paper contends, is the intergenerational reproduction crisis brought about by the aging of the labor force and the urbanization of the younger generation.