bluuebunny/crossref_metadata_2025_split huggingface dataset:
Median mandibulotomy: A critical assessment
Authors: Dubner Sanford , Spiro Ronald H. 
Published: February 2007

AbstractMedian mandibulotomy (mandibular “swing”) has supplanted mandibular resection for access to oral and oropharyngeal tumors when there is intervening grossly normal tissue between the tumor and bone. It has also proved useful for exposure in selected patients with deep lobe parotid or parapharyngeal space tumors. We have reviewed our experience with 313 mandibulotomies performed between 1959 and 1988 with emphasis on indications, complications, and modifications in technique. Most of our mandibulotomy patients had an uncomplicated recovery, but osteotomy‐related compliations occurred in 20%. These complications were usually minor and no instances of nonunion were recorded. There was no apparent relationship to antecedent or postoperative radiotherapy. Dental splints were used only in selected patients (40%). The technique of osteotomy has been evolving in recent years. Paramedian, rather than median mandibulotomy, minimizes trauma to the genioglossus, geniohyoid, and digastric muscles. Miniplates offer a useful alternative to conventional wire fixation. Preoperative dental assessment has facilitated better occlusion postoperatively in dentulous patients.
Hürthle cell carcinoma of the thyroglossal duct
Authors: Adler Mayer , Freeman Jeremy L. 
Published: February 2007

AbstractA thyroglossal duct cyst is an embyrologic remnant that often manifests as a swelling in the midline of the neck. The development of a carcinoma in a cyst is rare but well recognized. The majority of those reported are papillary carcinoma; there have been 4 cases of mixed follicular‐papillary (which biologically and clinically behaves as a papillary carcinoma) and only 1 follicular. A computer search of the literature revealed no previous report of a Hürthle cell carcinoma arising in a thyroglossal duct. A case of Hürthle cell carcinoma arising in a thyroglossal duct is presented, and the pathology, clinical manifestations, and management are reviewed.
Aneurysm of the internal jugular vein manifesting after prolonged positive pressure ventilation
Authors: Spiro Scott A. , Coccaro Stephen F. , Bogucki Eugene 
Published: February 2007

AbstractTrue internal jugular vein aneurysms are exceedingly rare anomalies. To date very few case reports have appeared regarding this entity. We present a case of a congenital internal jugular venous aneurysm which manifested itself after abdominal surgery and prolonged positive pressure ventilation. A theory regarding its manifestation is presented. We believe this case to be unique in its presentation.
Aneurysmal bone cyst of the cricoid cartilage: An unusual cause of subglottic stenosis
Authors: Sercarz Joel A. , Robert Marie , Alessi David , Fu Yao S. , Calcaterra Thomas C. 
Published: February 2007

AbstractAneurysmal bone cysts (ABC) are locally aggressive bony tumors which rarely occur in the head and neck. Only 3 cases have been reported in the larynx previously, 1 involving the cricoid cartilage. A patient is presented who developed subglottic stenosis with airway compromise due to an ABC arising from the cricoid cartilage. The literature on bony tumors of the laryngeal cartilages was reviewed and the clinical and pathologic findings in this case highlighted.
Radiotherapy for chemodectoma of the carotid body and ganglion nodosum
Authors: Guedea Fernando , Mendenhall William M. , Parsons James T. , Million Rodney R. 
Published: February 2007

AbstractChemodectomas of the carotid body and of the glomus vagale are uncommon tumors of the head and neck. Between 1981 and 1986, 6 patients with advanced chemodectomas of either the carotid body (5 patients) or the glomus vagale (1 patient) were treated with radiotherapy at the University of Florida. Tumors were bilateral in 2 patients. Five patients have had no evidence of disease progression for 5, 5.5, 7, 7, and 8.5 years following irradiation. One of the 5 patients experienced complete regression, 2 noted partial regression, and 2 remained stable (without progression). One patient, who had received 2 prior operations and a course of irradiation at another institution, died of locally recurrent disease 5 years after re‐irradiation at the University of Florida. No patient experienced a significant complication secondary to irradiation.
Serous otitis media and paranasopharyngeal extension of nasopharyngeal carcinoma
Authors: Sham Jonathan S. T. , Wei William I. , Lau S. K. , Yau C. C. , Choy D. 
Published: February 2007

AbstractTwo hundred thirty‐two patients with nasopharyngeal carcinoma were evaluated for serous otitis media (SOM) at diagnosis. The diagnosis of SOM required the detection of effusion behind the tympanic membrane in association of air‐bone gap of 10 dB or more in pure tone audiogram. These patients were also evaluated by computed tomography for the degree of tumor extension. By stepwise logistic regression analysis, the degree of paranasopharyngeal extension of tumor, erosion of petrous temporal bone, and the obliteration of pharyngeal recess were significantly related to the development of SOM, but sex and age were not. The findings of computed tomography may influence the plan of management for SOM in patients with nasopharyngeal carcinoma at diagnosis.
Recent results of oral cancer research in Kerala, India
Authors: Sankaranarayanan R. , Nair M. Krishnan , Mathew Babu , Balaram Prabha , Sebastian Paul , Dutt Suresh Chandra 
Published: February 2007

AbstractFindings from a research program in oral cancer at Regional Cancer Centre, Trivandrum, Kerala, India are reviewed. There is evidence of immune impairment in oral cancer patients. Plant lectins are being investigated for specific binding characteristics in various oral precancers and different histological subtypes of oral cancer. Tobacco and alcohol have been identified as the major risk factors for oral cancer. The chemopreventive potential of carotenoids and retinoids have been evaluated in oral leucoplakias. Beta‐carotene and vitamin A in heavier doses induced remission of oral leukoplakias in 25%‐50% of trial participants who continued with their tobacco and alcohol habits during the trial. The remission could be maintained with lower doses. Less than 20% of our patients with oral cancer were initially seen in localized stages. Various community‐oriented programs for prevention of primary and secondary oral cancers are being evaluated. These include antitobacco health education, oral self‐examination, and oral examination by trained volunteers. The results of radical radiotherapy and surgical salvage of radiation failure are also discussed. The 5‐year disease‐free survival rate of 34% is a reflection of the advanced stages of the disease when initially seen. Salvage rates with surgery for radiation failures were encouraging.
Resection of advanced cervical metastasis prior to definitive radiotherapy for primary squamous carcinomas of the upper aerodigestive tract
Authors: Byers Robert M. , Clayman Gary L. , Guillamondequi Oscar M. , Peters Lester J. , Goepfert Helmuth 
Published: February 2007

AbstractThirty‐five previously untreated patients with stage IV squamous cell carcinoma of the upper aerodigestive tract with advanced neck disease (mass > 3 cm) but with primary lesions thought to be locally controllable with radiotherapy were selected between 1972 and 1988 for treatment by neck dissection followed by radiotherapy: postoperative to the neck and definitive to the primary. Limited neck dissections spared muscles, nerves, and vasculature structures unless clinically involved with cancer. All patients received at least 50 Gy, postoperatively, to the entire neck with doses of up to 75 Gy being delivered to the primary treatment portals. Regional (neck) failure occured in 11% (4 of 35) patients. Overall, 5‐year survival from cancer was 55%. Multiple levels of neck involvement were associated with poorer survival than a single large node; however, the difference was not statistically significant. Delay in the institution of radiotherapy following surgery adversely affected survival (p = 0.01). This study demonstrates that in selected patients it is possible to resect advanced nodal metastasis prior to treating the primary with radiotherapy without compromising cancer control.
Serratus anterior muscle in composite head and neck flaps
Authors: Loannides Charis , Fossion Eric , Boeckx Willy 
Published: February 2007

AbstractThe serratus muscle (SAM) can be raised as an isolated muscular or osteomuscular flap on its nutrient vessels or in combination with a latissimus dorsi (LD) myocutaneous flap on the thoracodorsal pedicle for various reconstructive purposes. The aim of the present is to report on the results achieved after the use of the SAM alone (n = 7) and in combination with an LD (n = 3) after tumor resection or osteoradionecrosis (ORN) in ten patients with defects of the head and neck. One flap was lost due to venous thrombosis. The donor site morbidity was minimal. Emphasis is given on a new indication, namely ORN of the mandible. Short‐term results show that the use of the SAM prevents a pathologic fracture in cases of a class IIIa osteoradionecrotic mandible. More extensive use of the SAM flap is advocated.
Carcinoma of the nasopharynx: Analysis of treatment results in 167 consecutively admitted patients
Authors: Johansen Lars Vendelbo , Mestre Miguel , Overgaard Jens 
Published: February 2007

AbstractRadiotherapy with curative intent was administered to 159 of 167 consecutively admitted patients with nasopharyngeal carcinoma. The classification (UICC 1982) gave the staging: stage I 8%, stage II 2%, stage III 28%, and stage IV 61%.The actuarial local tumor control was 54% and correlated to the T‐classification. Primary control of neck nodes was 67% but was not correlated to the N‐classes. Distant failure occurred in 20% of the patients; this was correlated to the N‐classification. The 10‐year actuarially corrected survival rate was 37% (stage I + II 60%, stage III 49%, stage IV 27%). Late reactions were seen in 69%, and most patients had mild to moderate xerostomia. Men with high hemoglobin had a better prognosis than men with values in the lower part of the normal range. It is concluded that primary control in the T‐ and N‐positions is the parameter most crucial to success.
Cisplatin‐based chemotherapy in advanced adenoid cystic carcinoma of the head and neck
Authors: Dick Haan L. De , De Mulder Pieter H. M. , Vermorken Jan B. , Schornagel Jan H. , Vermey A. , Verweij Jaap 
Published: February 2007

AbstractNineteen patients, nine men and 10 women, with advanced adenoid cystic carcinoma (ACC), were treated with cisplatin either alone or in combination with doxorubicin and bleomycin. Median age was 51 years (range: 32‐73 years). Two groups of patients were distinguished: Group 1 (N = 10) received single‐agent cisplatin (50‐120 mg/m2 IV every 4 weeks) for locoregional recurrence (N = 4), pulmonary metastases (N = 5), or as neoadjuvant therapy (N = 1). Five patients failed previous chemotherapy. No objective responses were observed, five patients showed stabilization of their disease for a median duration of 20 months (range: 3‐50 months). Group 2 (N = 9) received a combination of cisplatin (20 mg/m2 IV on days 1‐5), doxorubicin (50 mg/m2 IV on day 1), and bleomycin (30 mg IV on days 1‐5), every 3 weeks. A complete remission (CR) was seen in one patient, lasting for 2 years, a partial remission (PR) in two patients (duration: 6 months and 6 years) (33%), and a stable disease (SD) in five patients (median duration: 15 months; range 3‐24 months). One patient showed progression from the start. The observed toxicity was acceptable: dose reduction was required in five patients for myelosuppression or impairment of renal function; vomiting grade III (WHO) was seen in 10 patients. The median progression‐free survival was 36 months (range: 7‐77 months). Median overall survival was 81 months (range: 14‐216 months). The role of cisplatin in this disease remains questionable. © 1992 John Wiley & Sons, Inc.
Epithelial membrane antigen and S‐100 protein‐labeled cells in primary and metastatic laryngeal carcinomas
Authors: Nakashima Tadashi , Yano Gen , Hayashi Itsuroh , Katsuta Yasaburoh 
Published: February 2007

AbstractImmunohistochemical studies were done on the expression of S‐100 protein‐labeled cells in human laryngeal carcinoma of epithelial membrane antigen (EMA) and on the population density. EMA was detected in 65 of 76 (86%) squamous cell carcinomas and was usually more extensively positive in well and moderately differentiated carcinomas. Thus, EMA can serve as a marker of malignancy in laryngeal carcinomas. The population density of S‐100 protein‐labeled cells was high in well‐differentiated tissues. In the metastatic tumors, the number of S‐100 protein‐labeled cells decreased as compared to findings in the primary tumors. As a statistically significant difference in survival curve was noted between groups with low and intermediate density of S‐100 protein‐labeled cells, the infiltration of S‐100 protein‐labeled cells seems to be associated with a better prognosis. © 1992 John Wiley & Sons, Inc.
Esthesioneuroblastoma and neck metastasis
Authors: Davis Richard E. , Weissler Mark C. 
Published: February 2007

AbstractEsthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the cribriform olfactory epithelium. Its aggressive biologic behavior is characterized by inapparent submucosal spread, local recurrence, atypical distant metastases, and poor long‐term prognosis. Historically, the suspicion of neck metastasis has not been associated with ENB. A retrospective review of all ENB patients treated at the University of North Carolina Hospitals since 1972 has revealed an unusually high incidence of cervical metastases (four of four patients). This prompted a review of the ENB surgical literature. All English‐literature series published since the widespread use of craniofacial surgery with accruals of eight or more patients were examined for reports of neck metastasis. Although the cumulative cervical metastatic rate reached 27% (55 of 207 patients), most authors failed to recognize the potential risk of cervical metastasis in ENB. Furthermore, in patients suffering from Kadish stage C disease, the cervical metastatic rate climbed to 44% (25 of 57 Kadish stage C patients). This further emphasizes the importance of the neck as a high‐risk metastatic site. These findings suggest that cervical metastases may be an important consideration in the evaluation and treatment of patients suffering from ENB. Strategies for evaluation and management of the neck are discussed. © 1992 John Wiley & Sons, Inc.
Temporomandibular arthritis in familial mediterranean fever
Authors: Tovi Ferit , Gatot Albert , Fliss Dan 
Published: February 2007

AbstractTemporomandibular joint arthritis is a rare manifestation of familial Mediterranean fever and should be considered in patients of Mediterranean origin. Recently we treated four patients suffering from this condition, and intra‐articular corticosteroid injection resulted in rapid resolution of the pain and disability in two. Computed tomography confirmed the usefulness of this therapeutic modality. © 1992 John Wiley & Sons, Inc.
Accuracy of intraoperative frozen section diagnosis in head and neck surgery: Experience at a university medical center
Authors: Gandour‐Edwards Regina F. , Donald Paul J. , Wiese David A. 
Published: February 2007

AbstractWe performed 2,210 intraoperative frozen sections on 258 patients from the Otolaryngology–Head and Neck Surgery Service in 1990 and 1991. Surgery involved a wide variety of benign and malignant lesions. Techniques included biopsies for diagnosis, simple excisions, thyroid and salivary gland surgeries, lymph node biopsies, composite resections with radical neck dissections, laryngectomies, and skull base surgeries. During the 2‐year period, 1,947 (88.1%) sections were requested for evaluation of surgical margins, 258 (11.7%) for diagnosis, and five (0.2%) cases for tissue identification. There was disagreement between the frozen section and permanent section in 46 (2.1%) cases, and the deferral diagnosis rate was 0.8%. Disagreements were the result of sampling errors in 33 and interpretive errors in 13 cases. There were six (0.3%) false‐negative diagnosis of malignancy and four (0.2%) false‐positive diagnoses of malignancy. Three of these had an impact on patient care as discussed. We recommend careful sampling and sectioning of small biopsies and the need for vigilant communication between surgeon and pathologist.
Cervical and mediastinal abscess as a manifestation of histoplasmosis
Authors: Lydiatt William M. , Emanuel Jane M. , Lydiatt Daniel D. 
Published: February 2007

AbstractHistoplasmosis is the most common endemic respiratory mycosis in the United States. Disseminated histoplasmosis generally is initially seen with systemic or respiratory complaints. Presentation of histoplasmosis as a neck mass is rare. Due to this unusual presentation and the diagnostic implications, we present a case of disseminated histoplasmosis that presented as a neck abscess. Unusual presentations of histoplasmosis may occur even in patients who are not immunocompromised. The diagnosis and management of histoplasmosis is reviewed. Histoplasmosis should be considered in the workup of a cervical abscess even in the immunocompetent host.
Phaeohyphomycosis of the paranasal sinuses masquerading as a neoplasm: A case report
Authors: Mehta Samir A. , Kaul Sameer , Mehta Mona S. , Kelkar R. S. , Mehta Ashok R. 
Published: February 2007

AbstractA case of fungal infection of the paranasal sinuses simulating a neoplasm is reported. Fonsecaea pedrosoi, a dematiacious fungus, which has not been previously reported, was responsible for this unusual infection. Fungal infection may mimic malignant lesions of the paranasal sinuses; however, coexisting malignancy must be ruled out.
Cavernous sinus involvement in head and neck cancer
Authors: Bumpous Jeffrey M. , Maves Michael D. , Gomez Sandra M. , Levy Beth K. , Johnson Frank 
Published: February 2007

AbstractSpread of tumor to intracranial structures is an infrequent and late manifestation of head and neck cancers. We recently encountered six patients with a distinct clinical syndrome due to involvement of the cavernous sinus, which forms the basis of this report. This syndrome was a source of significant morbidity and mortality, with a mean survival of only 4 months. The diagnosis is often elusive, but is now made more commonly than previously. Whether this reflects increased incidence (due to alterations in the natural history of disease by therapy) or improved diagnosis (due to modern imaging modalities) is unknown. Cavernous sinus involvement may be the first evidence of distant disease in head and neck cancer. Although survival is poor, palliation is worthwhile. Awareness of this syndrome can lead to earlier diagnosis and alteration of treatment.
Acinic cell carcinoma of the parapharyngeal space: Case report
Authors: Yokoyama Masato , Nomura Yasuya , Semba Tetsuo 
Published: February 2007

AbstractWe describe a case of acinic cell carcinoma (ACC) of the parapharyngeal space in a 58‐year‐old woman. A tumor originating from the deep lobe of the parotid gland was totally excised by an external cervical approach. The occurrence of ACC in the parapharyngeal space is extremely rare. We discuss the management, especially surgical procedure, of ACC in this area.
Clinical significance of laminin deposition and t‐cell infiltration in oral cancer
Authors: Noguchi Makoto , Kohama Gen‐Iku , Hiratsuka Hiroyoshi , Sekiguchi Takashi 
Published: February 2007

AbstractBiopsied specimens from 55 patients with squamous cell carcinoma (SCC) of the oral cavity were examined immunohistopathologically as to the clinical significance of basement membrane (BM) deposition and T‐cell infiltration at the tumorstromal border using monoclonal anti‐laminin and anti‐CD3 antibodies. According to the immunoreactivity, all specimens could be divided into three groups: group A, a continuous linear pattern of positive staining for BM around tumor nests; group B, an alteration of BM deposition around tumor nests with T cell infiltration into those tumor nests; and group C, an alteration of BM deposition around tumor nests without T cell infiltration into those tumor nests. These groups were correlated with clinical manifestations, such as tumor size, tumor regression rate with induction chemotherapy, and regional lymph node metastatic rate. In these groups, tumors classified as group C showed a trend toward resistance to chemotherapy and high metastatic characteristics. Tumors classified as group B, which showed the same alteration of BM deposition as a result of T cell infiltration into the tumor nests, showed a sufficient tumor regression rate with chemotherapy. The visualization of the staining for BM laminin and T cells in oral SCC appeared not only to increase our understanding of the biologic and clinical behavior of individual tumors, but could be a prognostic indicator.
Radiotherapy for basaloid squamous cell carcinoma of the head and neck
Authors: Larner James M. , Malcolm Ronald H. , Mills Stacey E. , Frierson Henry F. , Banks Evelyn R. , Levine Paul A. 
Published: February 2007

AbstractBasaloid squamous cell carcinoma (BSCC) of the head and neck is a recently described high‐grade variant of squamous cell carcinoma. It is a biologically virulent neoplasm with a propensity for nodal, as well as systemic, metastases. Because of the limited number of published reports, we reviewed data from patients of the University of Virginia Health Sciences Center and identified 16 cases of BSCC. The intent of this study was to determine the role of radiotherapy in the treatment of BSCC and better define the clinical features of this entity. Radiotherapy alone, or in combination with surgery, resulted in excellent local control rates. Distant metastases, chiefly pulmonary, occurred in more than half of the patients.
Salvage surgery of cervical recurrences after neck dissection or radiotherapy
Authors: Grandi Cesare , Mingardo Massimo , Guzzo Marco , Licitra Lisa , Podrecca Stefano , Molinari Roberto 
Published: February 2007

AbstractA series of 113 patients operated on in the period 1980–1989 for a neck recurrence from a head and neck cancer was studied. All patients had no other evidence of disease. The male/female ratio was 93/20, and the median age was 58 years (range 28–87). Previous treatment consisted of surgery (SG) ± radiotherapy (RT) in 81 patients (SG group) and only RT in 32 (RT group): 59 cases presented a relapse in the treated neck and 54 in the contralateral side. All but one contralateral recurrences were in the SG group. Ten patients were lost to followup. The observed 5‐year survival rate of the whole series was 29.2% (95% confidence interval, 0%–38%). Considering patients with ipsilateral recurrences, the 5‐year disease‐free survival rate was 38.7% (95% c.i., 28.7%–48.7%) and 27% (95% c.i., 18%–36%) for the SG and the AT group, respectively. The 5‐year disease‐free survival rate after SG for contralateral recurrences was 38.8% (95% c.i., 23.8%–53.8%). Dimension and mobility of the neck nodes were the only demonstrable prognostic factors.