bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen‐Bonded Organic Frameworks Enabling Highly Robust Aqueous Phase Ultralong Room‐Temperature Phosphorescence
Authors: Luo Wuzhen , Zhou Jiayin , Nie Yujing , Li Feiming , Cai Shunyou , Yin Guangqiang , Chen Tao , Cai Zhixiong 
Published: March 2024

AbstractAqueous phase room‐temperature phosphorescence (RTP) materials are attracting increasing interest owing to their unique optical properties and promising applications. However, the realization of ultralong aqueous state RTP remains a formidable challenge due to severe quenching of triplet excitons in aqueous medium. In this study, a universal strategy is presented to achieve aqueous RTP materials through the encapsulation of organic phosphors within rigid hydrogen‐bonded organic frameworks (HOFs) by in situ self‐assembly. Benefiting from the compact and rigid microenvironments provided by HOFs, the nonradiative dissipations are immensely suppressed and populated triplet excitons are greatly stabilized by geometrical confinement and isolating organic phosphors from quenchers. As a result, the assembled HOFs‐based materials reveal robust RTP emission with an ultralong phosphorescence lifetime of up to 493.1 ms and exhibit long‐term optical and structural stability in water and even in harsh conditions (acid and base) for more than 10 days. Moreover, a fluorescent dye is introduced to finely tune the afterglow performance based on triplet‐to‐singlet Förster resonance energy transfer (TS‐FRET), facilitating advanced information encryption and anticounterfeiting applications. This study provides a reliable and universal method to design and prepare robust RTP materials and expands their applications in advanced information encryption.
Inverse‐Vaccines for Rheumatoid Arthritis Re‐establish Metabolic and Immunological Homeostasis in Joint Tissues
Authors: Thumsi Abhirami , Martínez Diego , Swaminathan Srivatsan J. , Esrafili Arezoo , Suresh Abhirami P. , Jaggarapu Madhan Mohan Chandrasekhar , Lintecum Kelly , Halim Michelle , Mantri Shivani V. , Sleiman Yasmine , Appel Nicole , Gu Haiwei , Curtis Marion , Zuniga Cristal , Acharya Abhinav P. 
Published: March 2024

AbstractRheumatoid arthritis (RA) causes immunological and metabolic imbalances in tissue, exacerbating inflammation in affected joints. Changes in immunological and metabolic tissue homeostasis at different stages of RA are not well understood. Herein, the changes in the immunological and metabolic profiles in different stages in collagen induced arthritis (CIA), namely, early, intermediate, and late stage is examined. Moreover, the efficacy of the inverse‐vaccine, paKG(PFK15+bc2) microparticle, to restore tissue homeostasis at different stages is also investigated. Immunological analyses of inverse‐vaccine‐treated group revealed a significant decrease in the activation of pro‐inflammatory immune cells and remarkable increase in regulatory T‐cell populations in the intermediate and late stages compared to no treatment. Also, glycolysis in the spleen is normalized in the late stages of CIA in inverse‐vaccine‐treated mice, which is similar to no‐disease tissues. Metabolomics analyses revealed that metabolites UDP‐glucuronic acid and L‐Glutathione oxidized are significantly altered between treatment groups, and thus might provide new druggable targets for RA treatment. Flux metabolic modeling identified amino acid and carnitine pathways as the central pathways affected in arthritic tissue with CIA progression. Overall, this study shows that the inverse‐vaccines initiate early re‐establishment of homeostasis, which persists through the disease span.
From Fluorescence‐Transfer‐Lightening‐Printing‐Assisted Conductive Adhesive Nanocomposite Hydrogels toward Wearable Interactive Optical Information‐Electronic Strain Sensors
Authors: Su Gongmeiyue , Wang Ni , Liu Yangkun , Zhang Ruoyao , Li Zhao , Deng Yulin , Tang Ben Zhong 
Published: March 2024

AbstractThe interactive flexible device, which monitors the human motion in optical and electrical synergistic modes, has attracted growing attention recently. The incorporation of information attribute within the optical signal is deemed advantageous for improving the interactive efficiency. Therefore, the development of wearable optical information‐electronic strain sensors holds substantial promise, but integrating and synergizing various functions and realizing strain‐mediated information transformation keep challenging. Herein, an amylopectin (AP) modified nanoclay/polyacrylamide‐based nanocomposite (NC) hydrogel and an aggregation‐induced‐emission‐active ink are fabricated. Through the fluorescence‐transfer printing of the ink onto the hydrogel film in different strains with nested multiple symbolic information, a wearable interactive fluorescent information‐electronic strain sensor is developed. In the sensor, the nanoclay plays a synergistic “one‐stone‐three‐birds” role, contributing to “lightening” fluorescence (≈80 times emission intensity enhancement), ionic conductivity, and excellent stretchability (>1000%). The sensor has high biocompatibility, resilience (elastic recovery ratio: 97.8%), and strain sensitivity (gauge factor (GF): 10.9). Additionally, the AP endows the sensor with skin adhesiveness. The sensor can achieve electrical monitoring of human joint movements while displaying interactive fluorescent information transformation. This research poses an efficient strategy to develop multifunctional materials and provides a general platform for achieving next‐generation interactive devices with prospective applications in wearable devices, human‐machine interfaces, and artificial intelligence.
An Advanced Healthcare Sensing Platform for Direct Detection of Viral Proteins in Seconds at Femtomolar Concentrations via Aerosol Jet 3D‐Printed Nano and Biomaterials
Authors: Ali Md. Azahar , Zhang George Fei , Hu Chunshan , Yuan Bin , Gao Shou‐Jiang , Panat Rahul 
Published: March 2024

AbstractSensing of viral antigens has become a critical tool in combating infectious diseases. Current sensing techniques have a tradeoff between sensitivity and time of detection; with 10–30 min of detection time at a relatively low sensitivity and 6–12 h of detection at a high (picomolar) sensitivity. In this research, uniquely nanoengineered interfaces are demonstrated on 3D electrodes that enable the detection of spike antigens of SARS‐CoV‐2 and their variants in seconds at femtomolar concentrations with excellent specificity, thus, overcoming this tradeoff. The 3D electrodes, manufactured using a high‐resolution aerosol jet 3D nanoprinter, consist of a microelectrode array of sintered gold nanoparticles coated with graphene and antibodies specific to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) spike antigens. An impedance‐based sensing modality is employed to sense several pseudoviruses of SARS‐CoV‐2 variants of concern (VOCs). This device is sensitive to most of the pseudoviruses of SARS‐CoV‐2 VOCs. A high sensitivity of 100 fm, along with a low limit‐of‐detection of 9.2 fm within a test range of 0.1–1000 pm, and a detection time of 43 s are shown. This work illustrates that effective nano‐bioengineering of interfaces can be used to create an ultrafast and ultrasensitive healthcare diagnostic tool for combating emerging infections.
Humidity‐Induced Self‐Oscillating and Self‐Healing Hypercrosslinked Metal–Organic Polyhedra Membranes
Authors: Li Jiamin , Liu Zhaoyi , Liu Jinjin , Liu Xue , Luo Yang , Liang Jiajie , Zhang Zhenjie 
Published: March 2024

AbstractDesigning autonomously oscillating materials is highly desirable for emerging smart material fields but challenging. Herein, a type of hypercrosslinked metal–organic polyhedra (HCMOPs) membranes formed by covalent crosslinking of boronic acid‐modified Zr‐based MOPs with polyvinyl alcohol (PVA) are rationally designed. In these membranes, MOPs serve as high‐connectivity nodes and provide dynamic borate bonds with PVA in hypercrosslinked networks, which can be broken/formed reversibly upon the stimulus of water vapor. The humidity response characteristic of HCMOPs promotes their self‐oscillating and self‐healing properties. HCMOP membranes can realize a self‐oscillating property above the water surface even after loading a cargo that is 1.5 times the weight of the membrane due to the fast adsorption and desorption kinetics. Finally, the HCMOP actuator can realize energy conversion from mechanical energy into electricity when coupled with a piezoelectric membrane. This work not only paves a new avenue to construct MOP‐polymer hybrid materials but also expands the application scopes of MOPs for smart actuation devices.
Efficacy of lateral lymph node dissection for local control of rectal cancer: A multicenter study
Authors: Tanaka Yusuke , Hino Hitoshi , Shiomi Akio , Uehara Kay , Watanabe Jun , Nishikawa Takeshi , Ueno Hideki , Kinugasa Yusuke , Kawai Kazushige , Ajioka Yoichi 
Published: March 2024

AbstractBackgroundThis study aimed to evaluate the efficacy of lateral lymph node dissection (LLND) for rectal cancer by comparing the local control in patients with and without pathological lateral lymph node metastasis (LLNM).MethodsWe included 189 patients with rectal cancer who underwent total mesorectal excision and LLND at 13 institutions between 2017 and 2019. Patients with and without pathological LLNM were defined as the pLLNM (+) and (−) groups, respectively. Propensity score‐matching helped to balance the basic characteristics of both groups. The incidences of local recurrence (LR) and lateral lymph node recurrence (LLNR) were compared between the groups.ResultsIn the entire cohort, 39 of the 189 patients had pathological LLNM. The 3‐year LR and LLNR rates were 18.3% and 4.0% (p = 0.01) and 7.7% and 3.3% (p = 0.22) in the pLLNM (+) and (−) groups, respectively. After propensity score matching, the data from 62 patients were analyzed. No significant differences in LR or LLNR were observed between both groups. The 3‐year LR and LLNR rates were 16.4% and 9.8% (p = 0.46) and 9.7% and 9.8% (p = 0.99) in the pLLNM (+) and (−) groups, respectively.ConclusionLLND would lead to comparable local control in the pLLNM (+) and (−) groups if the clinicopathological characteristics except for LLNM are similar.
Coupling coarse‐grained DEM‐CFD and intraparticle model for biomass fast pyrolysis simulation and experiment validation
Authors: Wang Bing , Dai Jianjian , Li Sijie , Lin Yixi , Patrascu Michael , Gao Xi 
Published: March 2024

AbstractThe understanding of complex fluidization hydrodynamics and chemical reactions in biomass fast pyrolysis fluidized bed reactors is lacking and requires further investigation. It is urgent to develop accurate mathematical models capable of describing the complex multiphase reaction system of biomass pyrolysis. A comprehensive multiscale model based on coarse‐grained discrete element method (DEM)‐computational fluid dynamics (CFD) was developed in open‐source MFiX code. It incorporates detailed biomass pyrolysis kinetics and an intraparticle model. To validate the model, measurements were conducted in a fluidized bed pyrolyzer, including quantifying the segmental pressure drop along the height of the bed and determining the yields and compositions of gas, liquid, and solid products. The particle mixing and segregation, axial distribution and residence time, Lacey index, and pyrolysis products were investigated. The study provides experimental and theoretical foundations for designing multiphase fluidized bed reactors and advancing biomass thermochemical conversion.
Intracranial calcifications simulating Aicardi‐Goutières syndrome in PARS2‐related mitochondrial disease
Authors: Gerard Amanda , Mizerik Elizabeth , Mohila Carrie A. , AlAwami Sarah , Hunter Jill V. , Kearney Debra L. , Lalani Seema R. , Scaglia Fernando 
Published: March 2024

AbstractPARS2 encodes an aminoacyl‐tRNA synthetase that catalyzes the ligation of proline to mitochondrial prolyl‐tRNA molecules. Diseases associated with PARS2 primarily affect the central nervous system, causing early infantile developmental epileptic encephalopathies (EIDEE; DEE75; MIM #618437) with infantile‐onset neurodegeneration. Dilated cardiomyopathy has also been reported in the affected individuals. About 10 individuals to date have been described with pathogenic biallelic variants in PARS2. While many of the reported individuals succumbed to the disease in the first two decades of life, autopsy findings have not yet been reported. Here, we describe neuropathological findings in a deceased male with evidence of intracranial calcifications in the basal ganglia, thalamus, cerebellum, and white matter, similar to Aicardi‐Goutières syndrome. This report describes detailed autopsy findings in a child with PARS2‐related mitochondrial disease and provides plausible evidence that intracranial calcifications may be a previously unrecognized feature of this disorder.
Aluminagerma[5]pyramidanes—Formation and Skeletal Rearrangement
Authors: Bührmann Lukas , Albers Lena , Beuße Maximilian , Schmidtmann Marc , Müller Thomas 
Published: March 2024

AbstractThe salt metathesis reaction of dipotassium germacyclopentadienediide with aluminum(III) dichlorides provides either half‐sandwich alumole complexes of germanium(II) or aluminylene germole complexes. Their molecular structure and the delocalized bonding situation, revealed by density functional theory (DFT) calculations, are equally described as isomeric aluminagerma[5]pyramidanes with either the germanium or the aluminum atom in the apical position of the pentagonal pyramid. The product formation and the selectivity of the reaction depends on the third substituent of the aluminum dichloride. Aryl‐substituents favor the formation of alumole complexes and Cp*‐substituents that of the isomeric germole complexes. With amino‐substituents at the aluminum atom mixtures of both isomers are formed and the positional exchange of the two heteroatoms is shown by NMR spectroscopy. The alumole complexes of germanium(II) undergo facile reductive elimination of germanium and form the corresponding alumoles.
Electrochemical CO2 Activation and Valorization on Metallic Copper and Carbon‐Embedded N‐Coordinated Single Metal MNC Catalysts
Authors: Wang Xingli , Ju Wen , Liang Liang , Riyaz Mohd , Bagger Alexander , Filippi Michael , Rossmeisl Jan , Strasser Peter 
Published: March 2024

AbstractThe electrochemical reductive valorization of CO2, referred to as the CO2RR, is an emerging approach for the conversion of CO2‐containing feeds into valuable carbonaceous fuels and chemicals, with potential contributions to carbon capture and use (CCU) for reducing greenhouse gas emissions. Copper surfaces and graphene‐embedded, N‐coordinated single metal atom (MNC) catalysts exhibit distinctive reactivity, attracting attention as efficient electrocatalysts for CO2RR. This review offers a comparative analysis of CO2RR on copper surfaces and MNC catalysts, highlighting their unique characteristics in terms of CO2 activation, C1/C2(+) product formation, and the competing hydrogen evolution pathway. The assessment underscores the significance of understanding structure–activity relationships to optimize catalyst design for efficient and selective CO2RR. Examining detailed reaction mechanisms and structure‐selectivity patterns, the analysis explores recent insights into changes in the chemical catalyst states, atomic motif rearrangements, and fractal agglomeration, providing essential kinetic information from advanced in/ex situ microscopy/spectroscopy techniques. At the end, this review addresses future challenges and solutions related to today's disconnect between our current molecular understanding of structure–activity‐selectivity relations in CO2RR and the relevant factors controlling the performance of CO2 electrolyzers over longer times, with larger electrode sizes, and at higher current densities.
Cross‐Linkable Fullerene Enables Elastic and Conductive Grain Boundaries for Efficient and Wearable Tin‐Based Perovskite Solar Cells
Authors: Hou Enlong , Chen Jingfu , Luo Jiefeng , Fan Yuteng , Sun Chao , Ding Yu , Xu Peng , Zhang Hui , Cheng Shuo , Zhao Xinjing , Xie Liqiang , Yan Jiawei , Tian Chengbo , Wei Zhanhua 
Published: March 2024

AbstractTin‐based perovskite solar cells (TPSCs) have received increasing attention due to their low toxicity, high theoretical efficiency, and potential applications as wearable devices. However, the inherent fast and uncontrollable crystallization process of tin‐based perovskites results in high defect density in the film. Meanwhile, when fabricated into flexible devices, the prepared perovskite film exhibits inevitable brittleness and high Young's modulus, seriously weakening the mechanical stability. In this work, we design and synthesize a cross‐linkable fullerene, thioctic acid functionalized C60 fulleropyrrolidinium iodide (FTAI), which has multiple interactions with perovskite components and can finely regulate the crystallization quality of perovskite film. The obtained perovskite film shows an increased grain size and a more matched energy level with the electron transport material, effectively improving the carrier extraction efficiency. The FTAI‐based rigid device achieves a champion efficiency of 14.91 % with enhanced stability. More importantly, the FTAI located at the perovskite grain boundaries could spontaneously cross‐link during the perovskite annealing process, which effectively improves the conductivity and elasticity of grain boundaries, thereby giving the film excellent bending resistance. Finally, the FTAI‐based wearable device yields a record efficiency of 12.35 % and displays robust bending durability, retaining about 90 % of the initial efficiency after 10,000 bending times.
Improving stability of human three dimensional skin equivalents using plasma surface treatment
Authors: Phuphanitcharoenkun Suphanun , Louis Fiona , Sowa Yoshihiro , Matsusaki Michiya , Palaga Tanapat 
Published: March 2024

AbstractIn developing three‐dimensional (3D) human skin equivalents (HSEs), preventing dermis and epidermis layer distortion due to the contraction of hydrogels by fibroblasts is a challenging issue. Previously, a fabrication method of HSEs was tested using a modified solid scaffold or a hydrogel matrix in combination with the natural polymer coated onto the tissue culture surface, but the obtained HSEs exhibited skin layer contraction and loss of the skin integrity and barrier functions. In this study, we investigated the method of HSE fabrication that enhances the stability of the skin model by using surface plasma treatment. The results showed that plasma treatment of the tissue culture surface prevented dermal layer shrinkage of HSEs, in contrast to the HSE fabrication using fibronectin coating. The HSEs from plasma‐treated surface showed significantly higher transepithelial electrical resistance compared to the fibronectin‐coated model. They also expressed markers of epidermal differentiation (keratin 10, keratin 14 and loricrin), epidermal tight junctions (claudin 1 and zonula occludens‐1), and extracellular matrix proteins (collagen IV), and exhibited morphological characteristics of the primary human skins. Taken together, the use of plasma surface treatment significantly improves the stability of 3D HSEs with well‐defined dermis and epidermis layers and enhanced skin integrity and the barrier functions.
The association between lymphocyte to high‐density lipoprotein ratio and depression: Data from NHANES 2015–2018
Authors: Chen Junzhi , Huang Yan , Li Xiaolin 
Published: March 2024

AbstractIntroductionThe relationship of lymphocyte to high‐density lipoprotein ratio (LHR) with depression remains uncertain. We aimed to evaluate the association between LHR and depression in US adults.MethodsIn this cross‐sectional study, a total of 4216 participants were enrolled from the National Health and Nutrition Examination Survey (2015–2018). Depressive symptoms were measured with the Patient Health Questionnaire‐9 (PHQ‐9). Participants were classified as having depression if PHQ‐9 scores were ≥10. Multiple logistic regression models were used to explore the relationship between the LHR and depression.ResultsOverall, the LHR was significantly associated with depression (per standard deviation increment; adjusted odds ratio (OR), 1.31; 95% confidence interval (CI) [1.14, 1.50]) after adjusted potential variables. Interactions between LHR with metabolic syndrome (MetS) and body mass index (BMI) on the risk of depression were found in stratified analysis (p for interaction < .05).ConclusionsA higher level of LHR was significantly associated with higher odds of having depression in US adults, and it was strengthened in participants with MetS or BMI ranging from 25 to 30 kg/m2.
Evaluation of the Antiproliferative Potential of Yellow Jaboticaba (Myrciaria glazioviana) Extracts Against Human Cervical Cancer (HeLa cells line) and the Analysis of Their Chemical Composition by HPLC‐HRESIMS
Authors: Toledo Martins Pereira Mariana , Sardou Charret Thiago , Freimann Wermelinger Guilherme , Soares Ribeiro Nogueira Thalya , Kaufmann Robbs Bruno , Carvalho Castiglione Raquel , Loureiro Simões Rafael , Dantas Machado Ricardo Luiz , Curcino Vieira Ivo José , Abreu Lucas Silva , D'Avila Bitencourt Pascoal Vinicius , Rheder Fagundes Pascoal Aislan Cristina 
Published: March 2024

AbstractCervical cancer is a specific type of cancer that affects women around the world, with an incidence of 604 thousand new cases per year and 341 thousand deaths. There is a high demand for new effective antineoplastic drugs with few side effects. In this sense, recent research highlights the potential of compounds of natural origin in treating and preventing different types of cancer. Myrciaria glazioviana is a Brazilian native species belonging to the Myrtaceae family, which has previously described biological activities such as antimicrobial, anti‐inflammatory, and antioxidant properties. This study aims to evaluate the anticancer activity of the dichloromethane extract (MGD) and ethyl acetate extract (MGA) of M. glazioviana leaves against human cervical cancer cell line (HeLa), as well as to identify their bioactive compounds. Using HPLC‐HRESIMS technique, ten compounds were characterized in both samples: quinic acid, ellagic acid, Tri‐O‐methyl ellagic acid, two derivatives of Tetra‐O‐methyl flavellagic acid, quercetrin, Di‐O‐methyl ellagic acid, and three derivatives of pentamethyl coruleoellagic acid. Through MTT assays using HeLa cells and NIH/3T3 cells, it was observed that MGD and MGA were selective against tumor cells, with IC50 values of 24.31 and 12.62 μg/mL, respectively. The samples induced the tumor cell death by apoptosis, as evidenced by the activation of caspases 3/7, cell shrinkage, and pyknotic nuclei. Both samples were also able to inhibit the migration of HeLa cells after 24 hours of treatment, indicating a potential antimetastatic effect. Therefore, the present research highlights the antiproliferative and antimigratory potential of this species against HeLa cells.