bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carrying Capacity of Agricultural Land in Toll Road Construction in Sragen, Indonesia, 2011–2020
Authors: Asrofi M Z , Harini R 
Published: March 2024

Abstract
Sragen Regency has enormous agricultural potential and is among one of the largest rice suppliers for the population of Central Java, Indonesia. However, since the construction of the Solo-Kertosono toll road that passes through the regency, there have been more farmlands converted for non-agricultural purposes. This study was conducted to determine the extent of land conversion into a toll road and assess the carrying capacity of agricultural land from 2011 to 2020. To identify land conversion, data from the Purwodadi Road Management Center in the regency were analyzed. Meanwhile, the mathematical formula introduced by Odum et al. was applied to the secondary data obtained from the Bureau of Statistics to calculate carrying capacity. Results show that from 2011 to 2020, rice fields were converted most extensively into toll roads, with an average of 85.28% conversion. Further, the agricultural land’s carrying capacity in affected districts fluctuated across these years due to several factors, including harvested area, rice production, productivity, and water availability for irrigation.
Spatial Characteristic and Utilization Pattern of Riverside for Tourism Development in Yogyakarta
Authors: Widiyastuti D , Larasati N , Adhitama S Y , Pramesti S 
Published: March 2024

Abstract
The river as a natural attraction has the potential to be developed into a tourist attraction. In its development it requires space to accommodate tourist activities. Both main and supporting activities all require space, so that new spaces development tend to appear to facilitate these activities. Yogyakarta has been undergone an essential transformation in the spatial nature of its riverside due to tourism development. Therefore, this study focuses on the changes that occur in the riverside area due to tourism activities. This research focuses on the spatial characteristic and utilization patterns of riverside along three rivers in Yogyakarta through map analysis and field investigation. The constituent elements are determined, and then spatial characteristics are analysed in term of space used, activities and accessibility. The relationships between these characteristics and utilization pattern are discussed. The riversides developed for tourism activities have been undergone a fundamental change. There are significant relationships between utilization pattern and space used, activities and accessibility. The result presented here can provide a guidance for further development of riverside in Yogyakarta and beyond.
Optimal thermometers with spin networks
Authors: Abiuso Paolo , Andrea Erdman Paolo , Ronen Michael , Noé Frank , Haack Géraldine , Perarnau-Llobet Martí 
Published: March 2024

Abstract
The heat capacity

C

of a given probe is a fundamental quantity that determines, among other properties, the maximum precision in temperature estimation. In turn,

C

is limited by a quadratic scaling with the number of constituents of the probe, which provides a fundamental limit in quantum thermometry. Achieving this fundamental bound with realistic probes, i.e. experimentally amenable, remains an open problem. In this work, we tackle the problem of engineering optimal thermometers by using networks of spins. Restricting ourselves to two-body interactions, we derive general properties of the optimal configurations and exploit machine-learning techniques to find the optimal couplings. This leads to simple architectures, which we show analytically to approximate the theoretical maximal value of

C

and maintain the optimal scaling for short- and long-range interactions. Our models can be encoded in currently available quantum annealers, and find application in other tasks requiring Hamiltonian engineering, ranging from quantum heat engines to adiabatic Grover’s search.
Impact of Ross Gyre on surface circulation in the Amundsen Sea, Antarctica
Authors: He Hailun 
Published: March 2024

Abstract
The east limb of the Ross Gyre approaches the western Amundsen Sea, thereby exerting an influence on the surface circulation dynamics. This study investigates the impact of the zonal movement of the eastern boundary of the Ross Gyre on the surrounding surface geostrophic circulation in January. Specifically, a zonal shift of the eastern boundary of the Ross Gyre induces a substantial shelf-basin circulation within the Amundsen Sea. The findings of this study provide valuable insights into the influence of the Ross Gyre on the exchange processes between the Amundsen Sea shelf and basin.
Pluralist Republicanism: Race, Gender and Domination
Authors: Lippert-Rasmussen Kasper 
Published: March 2024

AbstractLaborde contrasts Default Republicanism with Labordian Republicanism. The latter view ‘answers’ the Probabilistic and the Anti-Psychology Objections to Default Republicanism. The former objection holds that the mere possibility of unconstrained intervention does not matter for unfreedom, whereas the latter contends that it is by virtue of the experience-independent fact of servitude that one is unfree. I argue that people sympathetic to these objections should have reservations about Labordian Republicanism. In any case, republicans should reject the Anti-Psychology Objection. More generally, Pluralist Republicanism might be preferable to Labordian Republicanism.
MoleMCL: a multi-level contrastive learning framework for molecular pre-training
Authors: Zhang Xinyi , Xu Yanni , Jiang Changzhi , Shen Lian , Liu Xiangrong 
Published: March 2024

Abstract

Motivation
Molecular representation learning plays an indispensable role in crucial tasks such as property prediction and drug design. Despite the notable achievements of molecular pre-training models, current methods often fail to capture both the structural and feature semantics of molecular graphs. Moreover, while graph contrastive learning has unveiled new prospects, existing augmentation techniques often struggle to retain their core semantics. To overcome these limitations, we propose a gradient-compensated encoder parameter perturbation approach, ensuring efficient and stable feature augmentation. By merging enhancement strategies grounded in attribute masking and parameter perturbation, we introduce MoleMCL, a new MOLEcular pre-training model based on multi-level contrastive learning.

Results
Experimental results demonstrate that MoleMCL adeptly dissects the structure and feature semantics of molecular graphs, surpassing current state-of-the-art models in molecular prediction tasks, paving a novel avenue for molecular modeling.

Availability and implementation
The code and data underlying this work are available in GitHub at https://github.com/BioSequenceAnalysis/MoleMCL.
Tryptophan metabolism and small fibre neuropathy: a correlation study
Authors: Kushibiki Hanae , Mizukami Hiroki , Osonoi Sho , Takeuchi Yuki , Sasaki Takanori , Ogasawara Saori , Wada Kanichiro , Midorikawa Shin , Ryuzaki Masaki , Wang Zhenchao , Yamada Takahiro , Yamazaki Keisuke , Tarusawa Takefusa , Tanba Taiyo , Mikami Tatsuya , Matsubara Atsushi , Ishibashi Yasuyuki , Hakamada Kenichi , Nakaji Shigeyuki 
Published: March 2024

Abstract
Small nerve fibres located in the epidermis sense pain. Dysfunction of these fibres decreases the pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting small fibre neuropathy. These findings suggest that various metabolic changes may be involved in small fibre neuropathy. Herein, we explored the correlation between pain sensation and changes in plasma metabolites in healthy Japanese subjects. The pain threshold evaluated from the intraepidermal electrical stimulation was used to quantify pain sensation in a total of 1021 individuals in the 2017 Iwaki Health Promotion Project. Participants with a pain threshold evaluated from the intraepidermal electrical stimulation index &lt;0.20 mA were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation index-low group (n = 751); otherwise, they were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation index-high group (n = 270). Metabolome analysis of plasma was conducted using capillary electrophoresis time-of-flight mass spectrometry. The metabolite set enrichment analysis revealed that the metabolism of tryptophan was significantly correlated with the pain threshold evaluated from the intraepidermal electrical stimulation index in all participants (P &lt; 0.05). The normalized level of tryptophan was significantly decreased in participants with a high pain threshold evaluated from the intraepidermal electrical stimulation index. In addition to univariate linear regression analyses, the correlation between tryptophan concentration and the pain threshold evaluated from the intraepidermal electrical stimulation index remained significant after adjustment for multiple factors (β = −0.07615, P &lt; 0.05). These findings indicate that specific metabolic changes are involved in the deterioration of pain thresholds. Here, we show that abnormal tryptophan metabolism is significantly correlated with an elevated pain threshold evaluated from the intraepidermal electrical stimulation index in the Japanese population. This correlation provides insight into the pathology and clinical application of small fibre neuropathy.
Mutation Rate of AmpC β-Lactamase–Producing Enterobacterales and Treatment in Clinical Practice: A Word of Caution
Authors: Maillard Alexis , Dortet Laurent , Delory Tristan , Lafaurie Matthieu , Bleibtreu Alexandre ,   for the Treatment of AmpC producing Enterobacterales study group, Azoulay Elie , Joseph Adrien , Molina Jean-Michel , Lafaurie Matthieu , Bercot Béatrice , Maillard Alexis , Paccoud Olivier , Bleibtreu Alexandre , Robert Jérôme , Drieux Laurence , Bernier Juliette , Villa Antoine , Maury Éric , Surgers Laure , Chopin Dorothée , Lalande Valérie , Tankovic Jacques , Delory Tristan , Contejean Adrien , Poupet Hélène , Mouthon Luc , Baillard Christophe , Escaut Lélia , Jaureguiberry Stéphane , Cuzon Gaëlle , Dortet Laurent , Chaibi Khalil , El Alaoui Fatma , Zahar Jean-Ralph 
Published: March 2024

Abstract
In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase–producing Enterobacterales, species with low in vitro mutation rates for AmpC derepression were associated with fewer treatment failures due to AmpC overproduction (adjusted hazard ratio, 0.5 [95% CI, .2–.9]). However, compared to cefepime/carbapenems, using third-generation cephalosporins as definitive therapy remained associated with this adverse outcome (15% vs 1%).
Prognostic value of left ventricular global longitudinal strain in transcatheter edge-to-edge repair for chronic primary mitral regurgitation
Authors: Shechter Alon , Hong Gloria J , Kaewkes Danon , Patel Vivek , Visrodia Parth , Tacon P Ryan , Koren Ofir , Koseki Keita , Nagasaka Takashi , Skaf Sabah , Makar Moody , Chakravarty Tarun , Makkar Raj R , Siegel Robert J 
Published: March 2024

Abstract

Aims
Left ventricular global longitudinal strain (LVGLS) is a known outcome predictor in transcatheter edge-to-edge repair (TEER) for functional mitral regurgitation (MR). We aimed to assess its prognostic yield in the setting of TEER for chronic primary MR.

Methods and results
We conducted a single-centre, retrospective analysis of 323 consecutive patients undergoing isolated, first-time procedures. Stratified by baseline LVGLS quartiles (≤−19%, −18.9% to −16%, −15.9% to −12%, &gt;−12%), the cohort was evaluated for the primary composite outcome of all-cause mortality or heart failure hospitalizations, as well as secondary endpoints consisting of mitral reinterventions and the persistence of significant residual MR and/or functional disability—all along the first year after intervention. Subjects with worse (i.e. less negative) LVGLS exhibited higher comorbidity, more advanced HF, and elevated procedural risk. Post-TEER, those belonging to the worst LVGLS quartile group sustained increased mortality (16.9% vs. 6.3%, Log-Rank P = 0.005, HR 1.75, 95% CI 1.08–4.74, P = 0.041) and, when affected by LV dysfunction/dilatation, more primary outcome events (21.1% vs. 11.5%, Log-Rank P = 0.037, HR 1.68, 95% CI 1.02–5.46, P = 0.047). No association was demonstrated between baseline LVGLS and other endpoints. Upon exploratory analysis, 1-month post-procedural LVGLS directly correlated with and was worse than its baseline counterpart by 1.6%, and a more impaired 1-month value—but not the presence/extent of deterioration—conferred heightened risk for the primary outcome.

Conclusion
TEER for chronic primary MR is feasible, safe, and efficacious irrespective of baseline LVGLS. Yet, worse baseline LVGLS forecasts a less favourable post-procedural course, presumably reflecting a higher-risk patient profile.
Measuring up: the significance of measurement invariance in cardiovascular research
Authors: Acuña Mora Mariela , Raymaekers Koen 
Published: March 2024

Abstract
Cardiovascular research frequently involves comparing patient-reported outcomes across groups. These groups can include individuals from different countries or those have different cardiovascular conditions, and it is frequently assumed that their understanding of the assessed outcome is similar. However, to ascertain that this is indeed the case, measurement invariance needs to be evaluated. This psychometric property helps us understand whether a test measures the same underlying construct in the same way across different groups. In the absence of measurement invariance, conclusions regarding group comparisons of the construct at hand may be inappropriate. This Methods Corner paper provides an overview of measurement invariance and an example of how it can be evaluated.
Different Host–Endogenous Retrovirus Relationships between Mammals and Birds Reflected in Genome-Wide Evolutionary Interaction Patterns
Authors: Zheng Wanjing , Gojobori Jun , Suh Alexander , Satta Yoko 
Published: March 2024

Abstract
Mammals and birds differ largely in their average endogenous retrovirus loads, namely the proportion of endogenous retrovirus in the genome. The host–endogenous retrovirus relationships, including conflict and co-option, have been hypothesized among the causes of this difference. However, there has not been studies about the genomic evolutionary signal of constant host–endogenous retrovirus interactions in a long-term scale and how such interactions could lead to the endogenous retrovirus load difference. Through a phylogeny-controlled correlation analysis on ∼5,000 genes between the dN/dS ratio of each gene and the load of endogenous retrovirus in 12 mammals and 21 birds, separately, we detected genes that may have evolved in association with endogenous retrovirus loads. Birds have a higher proportion of genes with strong correlation between dN/dS and the endogenous retrovirus load than mammals. Strong evidence of association is found between the dN/dS of the coding gene for leucine-rich repeat-containing protein 23 and endogenous retrovirus load in birds. Gene set enrichment analysis shows that gene silencing rather than immunity and DNA recombination may have a larger contribution to the association between dN/dS and the endogenous retrovirus load for both mammals and birds. The above results together showing different evolutionary patterns between bird and mammal genes can partially explain the apparently lower endogenous retrovirus loads of birds, while gene silencing may be a universal mechanism that plays a remarkable role in the evolutionary interaction between the host and endogenous retrovirus. In summary, our study presents signals that the host genes might have driven or responded to endogenous retrovirus load changes in long-term evolution.
The Spillover Effects of the Spouse’s Retirement on Depression: Evidence From Chinese Middle-Aged and Older Adult Couples
Authors: Xiong Xiaohan , Li Lin , Li Rui , Yang Hualei , Feng Amei 
Published: March 2024

Abstract

Objectives
The present study expands on previous research by examining whether the spouse’s retirement affects individual depression both directly, by the changes in individual health investment, and indirectly, through the social interaction effect of the couples’ depression.

Methods
Using the panel data from the 2010–2018 China Family Panel Studies, we investigate the direct and indirect spillover effects of the spouse’s retirement on depression among Chinese urban-worker couples (men aged 50–70, women aged 40–60; n = 10,466). To address the potential endogeneity and reflect the social interaction effect of the couples’ depression, we combine the Fuzzy Regression Discontinuity method with simultaneous equations.

Results
Overall, a spouse’s retirement would improve an individual’s depression, with the direct spillover dominating compared to the indirect spillover. Gender heterogeneity indicates that husbands’ depression is improved by wives’ retirement mainly because husbands might receive more healthcare and companionship provided by their retired wives, while wives’ depression is aggravated by husbands’ retirement because of the decline in household income and the lesser health investment. This difference is more evident when wives retire earlier and both spouses retire in the same year. With the spouse’s retirement years increasing, husbands’ depression improves and wives’ depression declines each year. Moreover, spouses’ depression is significantly interactive, and wives’ depression is more vulnerable to husbands’ depression.

Discussion
The results highlight that the health spillover effects of the spouse’s retirement need greater attention in future research and retirement reform.
Mother–Child Closeness and Adult Children’s Time and Financial Assistance
Authors: Lin I-Fen , Hammersmith Anna M 
Published: March 2024

Abstract

Objectives
Drawing on the intergenerational solidarity framework and life course perspective, the authors assessed how mother-child closeness across different life stages is associated with adult children’s time and financial assistance to mothers in later life.

Methods
Using children’s reports of their perceived closeness to mothers from Waves 1 to 4 of the National Longitudinal Study of Adolescent to Adult Health (Add Health) and mothers’ reports about adult children’s time and financial assistance from Wave 2 of the Add Health Parent Study (AHPS) in the United States, the authors investigated how mother-child closeness during adolescence, emerging adulthood, and young adulthood is related to midlife adult children’s support with a focus on difference between mother-daughter (N = 934) and mother-son (N = 899) dyads.

Results
Closeness during young adulthood was an important determinant of adult children’s time assistance to their mothers, regardless of child’s gender. Daughters’ closeness with mothers during young adulthood also had a direct association with their financial support to mothers but not sons’. In contrast, sons’ perceived closeness during emerging adulthood had a direct association with their financial support later in life. Closeness during adolescence had no direct association with later-life transfers of time or money but had an indirect association through its influence on mother-child relationships at subsequent life stages.

Discussion
Mother-child closeness is a continuously evolving process. Although mother-child bond formed during adolescence has no direct influence on help to mothers later in life, it shapes the progression of mother-child interactions over time that eventuates in support.
A physiologic roll for cell surface GlycoRNAs
Authors: Muller William A 
Published: March 2024

Abstract
Glycosylated RNA molecules that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent study (PMID 38262409) demonstrates that at least 1 function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycosylated RNA molecules bind to P-selectin but not E-selectin.
Evidence that keratinocyte microvesicle particles carrying platelet-activating factor mediate the widespread multiorgan damage associated with intoxicated thermal burn injury
Authors: Lohade Rushabh P , Brewer Chad , Rapp Christine M , Henkels Karen M , Zhang Wenfeng , Thyagarajan Anita , Singh Shikshita , Manjrekar Pranali , Sabit Taskin , Sahu Ravi P , Travers Jeffrey B 
Published: March 2024

Abstract
Thermal burn injuries can result in significant morbidity and mortality. The combination of ethanol intoxication with thermal burn injury results in increased morbidity through an exaggerated inflammatory response involving many organs. Recent studies have linked involvement of the lipid mediator platelet-activating factor (PAF) in the pathology associated with intoxicated thermal burn injury (ITBI). The present studies tested the roles of PAF and the elevated levels of subcellular microvesicle particles (MVP) generated in response to ITBI in the subsequent multiorgan toxicity. First, thermal burn injury of HaCaT keratinocytes preincubated with ethanol resulted in augmented MVP release, which was blocked by inhibiting the PAF-generating enzyme cytosolic phospholipase A2 and the PAF receptor (PAFR). Second, ITBI of mice resulted in increased proinflammatory cytokine production and neutrophilic inflammation in multiple organs, which were not present in mice deficient in PAFRs or the MVP-generating enzyme acid sphingomyelinase (aSMase). Moreover, the increased bacterial translocation from the gut to mesenteric lymph nodes previously reported in murine ITBI was also dependent on PAFR and aSMase. MVP released from ITBI-treated keratinocytes contained high levels of PAFR agonistic activity. Finally, use of topical aSMase inhibitor imipramine following ITBI attenuated the widespread organ inflammatory response of ITBI, suggesting a potential therapeutic for this condition. These studies provide evidence for PAF-enriched MVP generated in skin, which then act on the gut PAFR, resulting in bacterial translocation as the mechanism for the multiorgan dysfunction associated with ITBI. Inasmuch as aSMase inhibitors are widely available, these studies could result in effective treatments for ITBI.
Justified belief as an epistemic aim of education
Authors: Pfister Jonas 
Published: March 2024

Abstract
Critical thinking is considered to be a central epistemic aim of education. The claim may be about skills, but also about the state of justified belief. In opposition to this latter view, Alvin Goldman claimed that justification is only a means to true belief and that the only fundamental epistemic aim of education is true belief. Harvey Siegel’s response defended the view that justified belief is in fact a fundamental epistemic aim of education. In a recent article, Alessia Marabini and Luca Moretti analyse Siegel’s arguments, reject all of them, and provide two new ones. I defend one of Siegel’s arguments against their objection, raise some doubts about one of their own arguments, and give an additional argument against Goldman’s view.