bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structures of 1,4,13,16-Tetraoxa-7,10-dithia[16](1,1′)ruthenocenophane and Its 1:2 HgCl2 Complex
Authors: Sato Sadao , Habata Yoichi , Sato Masaru , Akabori Sadatoshi 
Published: July 2006

Abstract
The reaction of 1,1′-bis(6-chloro-1,4-dioxahexyl)ruthenocene with disodium 1,2-ethanedithiolate gave 1,4,13,16-tetraoxa-7,9-dithia[16](1,1′)ruthenocenophane (5) in 63% yield. The reaction of 5 with HgCl2 in acetonitrile gave a 1: 2 complex (6) in 47% yield. The crystal structure of complex 6 and its metal free ligand 5 were determined by an X-ray method. Crystal data: 5, triclinic, a=11.128(2), b=12.720(2), c=10.196(2)Å, α=113.55(1), β=64.13(1), γ=122.01(1)°, U=1074.1 Å3. P\bar1, Z=2, Dc=1.54 Mg m−3, μ(Mo Kα)=9 mm−1. R=0.028. 6, triclinic, a=16.595(4), b=12.645(3), c=7.401(1)Å, α=104.92(1), β=92.37(1), γ=69.38(2)°, U=1402.4Å3, P\bar1, Z=2, Dc=2.46 Mg m−3, μ(Mo Kα)=12.2 mm−1, R=0.081. The X-ray analysis of 6 revealed that one Hg atom was bonded to the Ru atom of the ruthenocene nucleus with a distorted trigonal-planar configuration and another Hg atom was bonded to the two sulfur atoms of the macrocycle. This result is completely different from that obtained regarding complex 4,7,10,13-tetraoxa-1,16-dithia[16](1,1′)ruthenocenophane with HgCl2.
Claisen Rearrangements of 5,6-Dideoxy-1,2-O-isopropylidene-α-d-xylo- and α-d-ribo-hept-5-eno-1,4-furanoses with Triethyl Orthoacetate
Authors: Tadano Kin-ichi , Shimada Kei-ichi , Miyake Akiko , Ishihara Jun , Ogawa Seiichiro 
Published: July 2006

Abstract
The (E)- and (Z)-isomers (2E and 2Z) of 3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-α -d-xylo-hept-5-eno-1,4-furanose were subjected to Claisen rearrangement with triethyl orthoacetate. Possible two diastereomers were obtained as a 1 to 1 mixture from both of 2Z and 2E, and also from their 3-hydroxy or 3-siloxy derivatives. On the other hand, the rearrangement of the corresponding d-ribo derivative (13Z) and its 3-O-(t-butyldiphenylsilyl) derivative proceeded with a high level of diastereoselectivity. By contrast, the (E)-isomer of 13Z showed no significant stereoselectivity, resulting in the formation of a diastereomeric mixture. The configurations of the introduced stereogenic centers by the rearrangements were unambiguously established by chemical transformations.
Behavior of the Enthalpy of Mixing in the Ternary Systems Lead–Antimony–Tin, Bismuth–Lead–Tin, and Bismuth–Cadmium–Tin at 950 K. II. Theoretical Aspects
Authors: Badawi Walid Ahmad 
Published: July 2006

Abstract
Analysis of the experimental results which have been obtained from our studies on the ternary systems Pb–Sb–Sn, Bi–Pb–Sn, and Bi–Cd–Sn revealed a new effect: deduction of a straight line obtained by interpolation between the pairs Sb–Pb and Sb–Sn at xPb=xSn=0.5 from the partial enthalpy of mixing of antimony, hSbm, yields a remainder quantity, rhSbm. The minimum of this remainder lies at the section drawing xPb/xSn=1. Further studies on the systems Bi–Pb–Sn and Bi–Cd–Sn indicated that the present “r-effect” is probably a general property of ternary solutions. The sign of the remainder rhim is opposite to that of hm of the pair of components existing vis-a-vis a third apex-component in the same ternary system. Systems of strong heteropolar character which indicate Wagner effect overlapped by III–V one could also exhibit r-effectt. Rules for the mixing behavior in binary systems are in some cases not applicable on the corresponding pairs in the ternary solutions.
Contribution to the Study of the Dielectric Relaxation Process of 1-Iodoalkanes
Authors: Muñoz Embid José , Fornies-Marquina José M\b{a} , Otin Santos 
Published: July 2006

Abstract
A study of the dielectric relaxation process of 1-iodoalkanes (from 1-iodopropane to 1-iodohexadecane) was carried out by measuring their static dielectric constants at 2 MHz and complex dielectric permittivities at 9.23 and 15.05 GHz, in the range of temperature 293.15–343.15 K. The 1-iodoalkanes are classified as belonging to an unsymmetrical distribution of relaxation times of Cole–Davidson type. Activation enthalpies for the relaxation process are obtained by fitting the data of relaxation time as a function of temperature 1to the Eyring equation. The influence of the aliphatic chain length in the 1-iodoalkane on the characteristic parameters of the relaxation process is discussed.
Isomerization in the 1,4,7,10,13,16-Hexaazacyclooctadecanecobalt(III) System [Co(hexacyclen)]3+, and Ion-Association Enhancement of the Unstable Facial Isomer
Authors: Searle Graeme H 
Published: July 2006

Abstract
The substitution reaction [Co(NH3)5(H2O)]3++hexacyclen·3H2SO4+6base+charcoal gives mer-[Co(hexacyclen)]3+ as the major product, and the equilibrium proportion of the fac isomer is &lt;1%. The commercial hexacyclen contains linpen (the open chain analogue of hexacyclen, generated by an elimination reaction in the Richman-Atkins cyclization synthesis procedure), so that the synthesis of complex yields [Co(linpen)]3+ isomers as co-products which complicate the isolation of the pure [Co(hexacyclen)]3+ isomers. Procedures are now given for obtaining the mer and fac isomers pure. In particular, the unstable fac isomer is obtained by isomerization of the mer in base in the presence of the strongly associating anion PO43−. This yields the new equilibrium mixture mer: fac: hydrolysis products=71:18:11, wherein the fac proportion is enhanced twenty times, enabling the pure fac isomer to be obtained in quantity. For the base-catalyzed isomerization reaction fac → mer in NaOH solutions at 50 °C, procedures are given for following the reaction by analyses of samples using ion-exchange HPLC (Na2SO4 elution) and by spectrophotometry. The mechanism must involve intramolecular bond rupture, but the kinetic results are not consistent with a simple SN1CB mechanism, and a two-step process involving an intermediate is indicated.
The Electrocapillary Curves of the Phosphatidylcholine Monolayer at the Polarized Oil–Water Interface. II. Double Layer Structure of Dilauroylphosphatidylcholine Monolayer at the Nitrobenzene–Water Interface
Authors: Kakiuchi Takashi , Nakanishi Masatoshi , Senda Mitsugi 
Published: July 2006

Abstract
Electrocapillary curves have been measured at the polarized nitrobenzene–water interface in the presence of dilauroylphosphatidylcholine (DLPC) in the nitrobenzene phase. DLPC formed a saturated monolayer when the concentration of DLPC was above 10 μmol dm−3. The area occupied by a DLPC molecule in the saturated monolayer was 0.93 nm2, indicating that the monolayer was in the liquid-expanded state. The stability of the monolayer was strongly affected by the electrical potential difference across the interface. The monolayer was stable when the interface was negatively polarized, i.e., the potential in the aqueous phase was negative with respect to that in the oil phase. The potential of zero charge shifted to a negative potential as the adsorption of DLPC increased, which indicated the specific adsorption of lithium ions in the aqueous phase to the head group of the DLPC molecules exposed to the aqueous phase. When the interface was positively polarized, the adsorption of DLPC abruptly decreased and the monolayer appeared to be disrupted.
Synthesis and Characterization of a 3-Thio-2,4-pentanedionate Pt(II) Complex; Bis(dimethylphenylphosphine)[2,4-pentanedione-3-thiolato(2−)-O,S]-platinum(II) Prepared by S–S Bond Cleavage of 2,3-Dithio-1,1,4,4-tetraacetylbutane
Authors: Yamazaki Shinsaku , Ama Tomoharu , Hojo Masashi , Ueno Tamio 
Published: July 2006

Abstract
3-Thio-2,4-pentanedionate (tac) complex of platinum(II), [Pt(tac)(PMe2Ph)2], has been prepared by treating [PtCl(PMe2Ph)3][PF6] with 2,3-dithio-1,1,4,4-tetraacetylbutane in a KOH/methanol–acetone mixed solution. This complex has been characterized by IR, 1H, 13C, and 31P NMR, secondary ion mass and ESR spectroscopy and cyclic voltammetry.
Complexation Reactions of Copper(II) Ions with 16-Membered and 18-Membered Monocyclic Dioxopolyamines in an Aqueous Solution
Authors: Kodama Mutsuo , Anan Hideki , Koike Tohru , Kimura Eiichi 
Published: July 2006

Abstract
The equilibria of complexation reactions of dioxo[16]aneN5, dioxo[18]aneN6, and their related compounds with copper(II) ions were determined potentiometrically. Making a sharp contrast to the 13–15-membered monocyclic dioxotetramine system, they interact with copper(II) ions in their neutral and doubly deprotonated forms, L and H−2L2−, yielding stable CuL2+ and CuH−2L0 complexes.
(2-Pyridylmethoxy)calixarenes: New Versatile Ionophores for Metal Extraction
Authors: Shinkai Seiji , Otsuka Toshio , Araki Koji , Matsuda Tsutomu 
Published: July 2006

Abstract
(2-Pyridylmethoxy)calix[n]arenes (n=6,8) were newly synthesized. It was shown in two-phase solvent extraction that they can extract not only alkali metal cations but Cu2+, Ag+, and UO22+ and are stable even at high pH. The results indicate that disadvantages of calixarene esters, which were previously developed as calixarene-based ionophores, can be improved by using the pyridyl group.
Detailed Dynamic NMR Study of a Molecular Gear, 1-Methoxy-9-(3,5-dimethylbenzyl)triptycene
Authors: Yamamoto Gaku 
Published: July 2006

Abstract
Stereodynamics of the title compound was studied by dynamic NMR spectroscopy. The “isolated” rotation of the aryl group was found to have a lower barrier than the correlated gear rotation.
Syntheses, and Crystal and Molecular Structures of Tetraethylammonium, and Tetrapropylammonium Tris(thiocyanato)cadmates(II), [R4N][Cd(SCN)3], (R=C2H5, C3H7)
Authors: Taniguchi Masahiro , Ouchi Akira 
Published: July 2006

Abstract
The title complexes have been synthesized and their crystal and molecular structures determined by a single crystal X-ray diffraction technique. [(C2H5)4N][Cd(SCN)3] (1) is orthorhombic with a space group of A21am; a=10.773(2), b=16.574(4), c=9.871(2) Å, and Z=4, while [(C3H7)4N][Cd(SCN)3] (2) is triclinic with a space group of P\bar1; a=10.297(5), b=11.542(5), c=9.374(3) Å, α=90.10(3), β=91.61(4), γ=80.94(4)°, and Z=2. In 1, the metal atom has a 3N,3S-hexa-coordinated octahedral geometry, and three ligated N atoms take fac-configuration. Each pair of a metal atoms are bridged by three thiocyanate (SCN) ions, where two SCN ions are S-coordinated, while the other is N-coordinated to the same side metal atom, forming a linear polymeric form. In 2, the metal atom is in a 3N,2S-penta-coordinated trigonal-bipyramidal geometry, where one non-bridging SCN ion is N-coordinated equatorially, while four bridging SCN ions are ligated with two N (axially), and two S atoms (equatorially), respectively. Each pair of metal atoms is bridged by two SCN ions, forming a linear polymeric form. The respective tetraalkylammonium ions in 1 and 2 are not bridged to the complex anions, but are bonded only electrostatically. The final R values obtained are: 1, 0.042 and 2, 0.052.
Halogenation Using Quaternary Ammonium Polyhalides. XIV. Aromatic Bromination and Iodination of Arenes by Use of Benzyltrimethylammonium Polyhalides–Zinc Chloride System
Authors: Kajigaeshi Shoji , Kakinami Takaaki , Moriwaki Masayuki , Tanaka Toshio , Fujisaki Shizuo , Okamoto Tsuyoshi 
Published: July 2006

Abstract
The reaction of arenes with benzyltrimethylammonium tribromide or benzyltrimethylammonium dichloroiodate in acetic acid in the presence of ZnCl2 at room temperature or at 70 °C gave bromo- or iodo-substituted arenes in good yield, respectively.
Reaction of 9-Diazofluorene with 2,3-Dichloro-5,6-dicyano-p-benzoquinone: The Structure and the Behaviors of the Resulting Product
Authors: Shingaki Tadao , Kuma Hiro , Kushi Yoshihiko , Nagai Toshikazu 
Published: July 2006

Abstract
The title reaction gave 3′,4′-dichloro-1′,6′-dicyanospiro[fluorene]-9,7′-[3′]norcarene]-2′,5′-dione (2) in a good yield. Recrystallizations of 2 from solvents such as benzene, dioxane, acetonitrile, and acetone gave each molecular complex consisting of a 2/solvent molar ratio of 1:1. The structure of 2 was determined by the use of one complex, 2·CH3COCH3, by an X-ray crystallographic analysis, which revealed that an interaction between 2 and acetone was not very strong. Such a host–guest interaction was shown also from 1H NMR spectroscopy and a differential thermal analysis of the complex. Compound 2 afforded the corresponding spiroacetals of 9-fluorenone through reactions with ethylene glycol and 1,3-propanediol.
Reversible Bond Switch with Participation of Hypervalent Sulfurane in a Thiadiazole Ring System and Its Kinetic Study in a Protonated System
Authors: Yamamoto Yohsuke , Akiba Kin-ya 
Published: July 2006

Abstract
The existence of ring transformation equilibrium (bond switch) in 5-(1-aminoethylideneamino)-3-methyl-1,2,4-thiadiazole (5a) was confirmed by nitrogen-15 labeling experiment. Kinetic studies were carried out under neutral or acidic conditions. Kinetic parameters of the intramolecular equilibration of the monoprotonated 5a (5a-H+) were obtained by line shape analyses of the 1H NMR, i.e., ΔG273\eweq=14.8±0.2, ΔH\eweq=11.6±1.0 kcal·mol−1 ΔS\eweq=−12±3 eu, k273=9 s−1. Position of protonation was determined at the nitrogen of the ethylideneamino part of the amidino group. It was concluded that the central sulfur atom moves back and forth in the range of 0.38 Å nine times a second at 0 °C, that is, bond switching.
Reactivities of Stable Rotamers. XXV. Deprotonation at the 9-Position of 9-(2-Substituted 1-naphthyl)fluorene Rotamers with Butyllithium
Authors: Moriyama Kazuhiro , Nakamura Mikio , Nakamura Nobuo , Oki Michinori 
Published: July 2006

Abstract
Deprotonation of 9-(2-substituted 1-naphthyl)fluorene rotamers, where the substituent is a dimethylamino, a methoxy, or a methylthio, has been carried out with butyllithium in hexane–benzene. While the reactions of the ap-isomers were generally slower than those of the sp-isomers, the difference in the methoxy compounds was the greatest among the compounds examined. The results are discussed on the basis of the ease of ligation of the substituent and the steric effects that prevail in the ap-isomers, together with the distance between 9-position and the ligation site in the subsituent.
Protease-Catalyzed Peptide Formation under High Pressure
Authors: Kunugi Shigeru , Tanabe Kazuo , Yamashita Kouji , Morikawa Yoshio , Ito Takanobu , Kondoh Toshihiro , Hirata Kouichirou , Nomura Akihiko 
Published: July 2006

Abstract
The effect of high pressure on peptide formation by the catalysis of carboxypeptidase Y (substitution of ester or peptide by amino acid derivative) or by thermolysin (condensation of N-acylamino acid and amino acid amide) was studied. The carboxypeptidase Y-catalyzed substitution reaction of N-[3-(2-furyl)acryloyl]phenylalanine ethyl ester with glycinamide or phenylalaninamide showed a six-fold higher total peptide yield at 200 MPa than at atmospheric pressure. In the case of the reaction of N-acyldipeptide and amino acid amide, both the peptide yield and substitution efficiency were improved at elevated pressure and the wasteful hydrolysis of the substrate was highly depressed by increasing pressure. The pressure was also effective to get rid of the substrate inhibition by the amino acid ester in the reaction between the N-acylamino acid ester and the amino acid ester and to yield much dipeptide ester at high pressure. An improvement of the peptide yield by pressure for the reaction of thermolysin was observed in a combination of less specific substrates, N-benzyloxycarbonyl-l-aspartic acid and phenylalanine methyl ester, since the high catalytic activity of this enzyme under elevated pressure was significant only in the case that the peptide yield was kinetic-controlled.
Cr(III) or Ce(IV) Impregnated Perfluorinated Resin–Sulfonic Acid Catalyst for the Oxidation of Alcohols
Authors: Kanemoto Shigekazu , Saimoto Hiroyuki , Oshima Koichiro , Utimoto Kiitiro , Nozaki Hitosi 
Published: July 2006

Abstract
Several polymer supported catalysts are prepared by treatment of Nafion®551 (abbreviated NAFK below) with metal salts. Cr/NAFK and Ce/NAFK are found to be effective catalysts for the dehydrogenative oxidation of alcohols to the corresponding ketones by means of t-butyl hydroperoxide. Selective oxidation of secondary alcohols in the presence of primary ones was performed using a Ce/NAFK–NaBrO3 system.
Development of a Facile Method for Polypeptide Synthesis. Synthesis of Bovine Pancreatic Trypsin Inhibitor (BPTI)
Authors: Aimoto Saburo , Mizoguchi Noriko , Hojo Hironobu , Yoshimura Shoko 
Published: July 2006

Abstract
A new method for the preparation of pure polypeptides based on the minimun-protection strategy is described. Its effectiveness was demonstrated by a synthesis of bovine pancreatic trypsin inhibitor (BPTI). Protected peptide segments of Z-[Arg(Tos)1, Asp(OcHex)3, Cys(Acm)5, Glu(OcHex)7]-BPTI(1–13), Boc-[Cys(Acm)14,30, Lys(Z)15,26]-BPTI(14–36), and [Cys(Acm)38,51,55, Lys(Z)41,46]-BPTI(37–58) were prepared by modifying the products obtained by solid-phase peptide syntheses. The protected peptides corresponding to BPTI(14–36) and BPTI(37–58) were coupled by an active ester method to give protected BPTI(14–58). Next, protected BPTI(1–13) was coupled to the BPTI(14–58) by an active ester method after removing the Boc group from the protected BPTI(14–58). All of the protecting groups on BPTI(1–58) were removed, and the resulting peptide was oxidized to give the native form of BPTI in a very pure form. The synthetic BPTI was shown to be identical with the native BPTI in an elution experiment on ion-exchange chromatography and in its inhibitory activity. The new method proved to be very effective for a rapid preparation of pure polypeptide.
3,3′-carbonylbis[5-phenyl-1,3,4-oxadiazole-2(3H)-thione]: A Novel, Reactive, and Versatile Condensing Agent for Amide, Ester, Thiol Ester, Urea, Carbonate, Polyamide, and Polyurea Syntheses
Authors: Saegusa Yasuo , Watanabe Tatsushi , Nakamura Shigeo 
Published: July 2006

Abstract
A novel condensing agent, 3,3′-carbonylbis[5-phenyl-1,3,4-oxadiazole-2(3H)-thione] (3), was readily prepared by the reaction of 5-phenyl-1,3,4-oxadiazole-2(3H)-thione with trichloromethyl chloroformate in benzene. The reagent 3 was found to be very useful for the one-pot or direct preparation of amide, ester, thiol ester, urea, and carbonate under mild conditions. The one-pot or direct polycondensation of several dicarboxylic acids with aromatic diamines and of aromatic diamines using 3 proceeded smoothly at ambient temperature to produce high-molecular-weight polyamides and polyureas, respectively.
X-Ray Crystal Structures of trans-(Chloromethyl)bis(2,4-pentanedionato)(aqua and methanol)chromium(III) Completes. Evidence for a Trans Influence Exerted in the Carbon-Bonded Chromium(III) Complexes
Authors: Abe Yoichi , Ogino Hiroshi 
Published: July 2006

Abstract
The crystal and molecular structures of alkylchromium(III) complexes, trans-[Cr(CH2Cl)(acac)2(H2O)]·EtOH and trans-[Cr(CH2Cl)(acac)2(MeOH)] (acac−=2,4-pentanedionate anion, EtOH=ethanol, MeOH=methanol), have been determined by X-ray structure analyses. Both crystals are triclinic and the space group P\bar1; Z=2 with a=9.935(2), b=10.606(2), c=9.399(2) Å, α=90.39(2), β=92.44(2), γ=115.54(1)° for the aqua complex, and Z=4 with a=11.402(6), b=16.780(7), c=8.543(3) Å, α=98.83(3), β=102.00(4), γ=83.03(4)° for the methanol complex. Each complex has trans configuration. The carbon-bonded CH2CI group elongates specifically the Cr–O bond trans to the Cr–C bond in the aqua complex (Cr–O(H2O)=2.134(6) Å) and methanol complex (Cr–O(MeOH)=2.156(6), 2.136(6) Å).
The Thermodynamics of the Micelle Formation of Sodium α,ω-Alkanediyl Disulfate
Authors: Ikeda Kenji , Nakasima Tomoko , Esumi Kunio , Meguro Kenjiro 
Published: July 2006

Abstract
The critical micelle concentrations of a α,ω-type surfactant: (sodium α,ω-alkanediyl disulfate: n=12, 14, 16) in an aqueous solution have been determined by studying the electrical conductivity, and the free energies of the micelle formation have then been estimated from these data. The free energy of micelle formation of a α,ω-type surfactant was smaller than that of a normal-type surfactant with the same alkyl chain length as the α,ω-type one. The free-energy changes per –(CH2)– segment was also calculated from these data. It is found that the free-energy change per –(CH2)–segment of the α,ω-type surfactant is −11.1 [kJ mol−1].
Single Crystals Coimaged with the Gigantic Rod-Like Micelles in Viscoelastic Cationic Surfactant–Aromatic Additive Systems
Authors: Hirata Hirotaka , Sakaiguchi Yuko 
Published: July 2006

Abstract
In a system of hexadecyltrimethylammonium bromide (HTAB)–salicylic acid (SA) in which a remarkable viscoelasticity is induced, we noticed the existence of single crystals coimaged with the infinitely elongated rod-like micelles. The single crystal implied the formation of a new species, a complex which resulted from the interaction of HTAB and aromatic additives.
Cyclization of Penta- and Hexapeptide Active Esters Related to Gramicidin S and Gratisin
Authors: Tamaki Makoto , Takimoto Michiaki , Hayashi Mitsuo , Muramatsu Ichiro 
Published: July 2006

Abstract
Four pentapeptide N-hydroxysuccinimide esters [X–Orn(Z)–Leu–Y–Pro–ONSu (X=Val or d-Val, and Y=Phe or d-Phe)] related to gramicidin S were allowed to cyclize in pyridine. The peptides with a l-Phe residue preceding Pro tend to form various cyclic polymers, while ones with a d-Phe residue exclusively yielded a cyclic monomer or cyclic dimer. Peptides with a d-Val residue at the N-terminal produced monomerization products. The observed tendencies were similar for cyclization of four hexapeptide N-hydroxysuccinimide esters [X–Val–Orn(Z)–Leu–Y–Pro–ONSu (X=Tyr(Bzl) or d-Tyr(BzlCl2), and Y= Phe or d-Phe)] related to gratisin.
Synthesis of (±)-Hernandulcin by an Intramolecular Nitrile Oxide Cycloaddition Route from Farnesol
Authors: Zheng Guo-Chi , Kakisawa Hiroshi 
Published: July 2006

Abstract
An intramolecular addition reaction of the nitrile oxide derived from (2Z, 6E)-farnesal oxime afforded an isoxazoline derivative, which was converted into hernandulcin, a sweet sesquiterpene of Verbenaceae plant.
The Reaction of Arylazo Aryl Sulfones with Carbon Monoxide and Nucleophiles Catalyzed by the Palladium(0) Complex
Authors: Kamigata Nobumasa , Satoh Akira , Yoshida Masato , Kameyama Masayuki 
Published: July 2006

Abstract
The reaction of arylazo aryl sulfone (1) with carbon monoxide in the presence of the palladium(0) catalyst affords substituted benzoic acid in a good yield, together with minor yields of diaryl ketone and biaryl. The reactions of 1 with carbon monoxide and such nucleophiles as alcohols and amines under similar conditions give esters and amides, respectively.
Synthesis of 10-(8-Aminooctyl)flavin and Its Use in Affinity Chromatography
Authors: Kasai Sabu , Nakano Hideko , Maeda Kazuya , Matsui Kunio 
Published: July 2006

Abstract
7,8-Dimethyl-10-(8-aminooctyl)isoalloxazine was synthesized by coupling N-(8-aminooctyl)-4,5-dimethyl-1,2-benzenediamine with alloxan. The flavin was immobilized to epoxy activated gel to use for affinity chromatography. The gel was effective for purification of riboflavinbinding protein from egg white and flavokinase from rat liver.
Formation and Reaction of Oxazoles. Synthesis of N-Substituted 2-(Aminomethyl)oxazoles
Authors: Ibata Toshikazu , Isogami Yasushi 
Published: July 2006

Abstract
The BF3-catalyzed reaction of substituted α-diazoacetophenones with chloroacetonitrile gave 5-aryl-2-chloromethyloxazoles (3) in high yields. Methyl p-nitrophenyldiazoacetate also yielded 2-(chloromethyl)-5-methoxy-4-(p-nitrophenyl)oxazole. The nucleophilic substitution of 3 with primary, secondary, and tertiary amines afforded the corresponding secondary amines, tertiary amines, and quaternary ammonium salts bearing a 2-oxazolylmethyl group.