bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy and safety of oral terbinafine in fungal mycetoma
Authors: N'Diaye Bassirou , Dieng Mame T. , Perez Antonio , Stockmeyer Marlies , Bakshi Rajesh 
Published: January 2006

AbstractObjectives  An open‐label study was performed to assess the efficacy and safety of terbinafine in the treatment of eumycetoma.Methods  Single‐center, open‐label study, including 27 patients with signs and symptoms of eumycetoma which had developed within 5 years and was confirmed by mycological examination. The intention‐to‐treat population (n = 23) received 500 mg of terbinafine bid for 24–48 weeks.Efficacy evaluations included clinical signs and symptoms (e.g. sinuses open or closed, degree of tumefaction, and emission of grains either present or absent); mycological examinations from Week 24 onwards; and investigators’ overall assessment of efficacy (cure, improved since baseline, unchanged since baseline, or deterioration since baseline). Safety evaluations included monitoring of adverse events, laboratory assessments, vital signs and physical examinations.Results  Good clinical improvement was seen in patients who completed the study (n = 20). Tumefaction was absent or improved in 80% of patients; sinuses were closed in 50% of patients, and grain emissions were absent in 65% of patients. Of the 16 patients who had repeat mycological assessment, four (25%) were mycologically cured. In the investigators’ overall opinion at the end of the study, five (25%) were cured and 11 (55%) were clinically improved. The majority of adverse events reported were mild to moderate, and consistent with the known tolerability profile of terbinafine.Conclusion  High‐dose terbinafine (1000 mg/day) is well tolerated and clinically effective in patients with eumycetoma, a difficult‐to‐treat subcutaneous mycoses.
Efficacy of autologous transplantation of noncultured epidermal suspension in two different dilutions in the treatment of vitiligo
Authors: Tegta Geeta R. , Parsad Davinder , Majumdar Subroto , Kumar Bhushan 
Published: January 2006

AbstractBackground  Previous reports have shown the effectiveness of a basal layer cell suspension in the treatment of stable vitiligo; however, there has been no mention in the literature until now of the optimal number of melanocytes required in an autologous noncultured epidermal suspension for transplantation to obtain early and acceptable results.Methods  In this randomized prospective study, we compared the efficacy of two different dilutions to determine the optimum density of melanocytes required for transplantation to achieve early and cosmetically acceptable results. We enrolled 20 patients with stable vitiligo with a body surface area involvement of < 10%.Results  Fifty per cent of patients in Group A (where the recipient area transplanted was approximately three times the size of the donor area, and the density of melanocytes transplanted per square millimeter was approximately 231.60 ± 27.03) showed marked (> 75%), 20% moderate, 10% mild, and 20% minimal repigmentation (or no response). In Group B (where the recipient area was increased to five‐fold the donor area), none of the patients showed marked, 10% showed moderate, 20% showed mild, and 70% showed either minimal or no repigmentation. The density of melanocytes transplanted in this group was 154.90 ± 27.65/mm2. The extent of repigmentation was significantly greater (P < 0.05) in Group A than in Group B, and the density of melanocytes in the suspension was also significantly greater (P < 0.01) in Group A than in Group B.Conclusion  We contend that the minimum number of melanocytes required to produce satisfactory repigmentation is probably in the range of 210–250/mm2.
Primary cutaneous coccidiodomycosis: case report and review of the literature
Authors: Gildardo Jaramillo Moreno , Leobardo Velázquez Arenas , Nora Mendez Olvera , Jorge Ocampo Candiani 
Published: January 2006

AbstractBackground  Coccidiodomycosis is a systemic infection caused by Coccidioides immitis, a dimorphic fungus endemic in the south of the USA and the north of Mexico. The disease usually affects the lungs. Primary cutaneous infection is extremely rare. We present a report of a patient with primary cutaneous infection located on the nose. To our knowledge, such a presentation has never previously been reported in the literature.Observations  The patient had a 3‐cm‐diameter elevated nodule with a verrucous aspect located on the tip of her nose. The histopathologic features of the lesion were consistent with coccidioidomycosis.Conclusions  To our knowledge, this is the first report of primary cutaneous coccidioidomycosis located on the tip of nose.
Leg ulcer in a patient associated with hydroxyurea therapy
Authors: Dissemond Joachim , Hoeft Daniela , Knab Julia , Franckson Tom , Kroger Knut , Goos Manfred 
Published: January 2006

AbstractHydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side‐effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long‐term treatment with hydroxyurea. Painful leg ulcers in association with hydroxyurea have only rarely been reported.We present a report of a 52‐year‐old patient with essential thrombocythemia suffering from painful leg ulcers 3 years after starting therapy with hydroxyurea. We decided to treat the leg ulcers following a modern phase‐adapted wound‐healing strategy and continued hydroxyurea therapy until complete healing of the ulcers.In conclusion, cutaneous ulceration of the leg is one adverse effect in patients with essential thrombocythemia during hydroxyurea therapy. Healing does not necessarily require discontinuation of the drug. Therefore, therapists should first optimize a conservative and systematic wound‐healing strategy. If these interventions fail, discontinuation of hydroxyurea therapy is advisable.
Leishmaniasis recidiva cutis due to Leishmania (Viannia) panamensis in subtropical Ecuador: isoenzymatic characterization
Authors: Calvopina Manuel , Uezato Hiroshi , Gomez Eduardo A. , Korenaga Masataka , Nonaka Shigeo , Hashiguchi Yoshihisa 
Published: January 2006

AbstractBackground  Information regarding leishmaniasis recidiva cutis (LRC), a clinical variant of cutaneous leishmaniasis, in the New World is scarce. LRC is characterized by slowly progressing lesion(s) that appear after a variable period of time, from months to years, in or around the scar of an apparently clinically healed sore.Patients and methods  Six patients are reported who presented with crusted, papular lesions located on the edge of a healed scar, with a mean of 18.2 months of slowly progressive evolution. The isolated strains of Leishmania parasites were characterized by enzyme electrophoresis. Eleven enzyme systems were assayed. Skin biopsies from the active border of the lesions were taken for histopathology.Results  Tissue sections showed a granulomatous, lymphohistiocytic, dermal infiltrate containing Langhans’ giant cells. The anamnestic data, together with the clinical and histopathologic findings, support the diagnosis of LRC. The isoenzyme profile of Leishmania parasites isolated from five of the six patients identified them as Leishmania (Viannia) panamensis.Conclusions  These findings are the first reported evidence of LRC within the clinical spectrum of American tegumentary leishmaniasis in Ecuador, and of its causative agent. The existence of LRC has future implications for both disease treatment and vaccine development.
Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery
Authors: Cowden Alissa , Dans Michael , Militello Giuseppe , Junkins‐Hopkins Jacqueline , Van Voorhees Abby S. 
Published: January 2006

AbstractBackground  Eccrine porocarcinoma (EPC) is a rare, malignant adnexal tumor that has been reported only three times specifically in African American individuals. Diagnosis and treatment of EPC is important, given the 20% local recurrence and regional metastatic rates. However, no standard of care has been developed to guide effective treatment.Methods  We report two distinct clinical presentations of EPC, both in African Americans, and discuss a review of the literature.Results  The neoplasms were successfully removed from both patients by Mohs micrographic surgery.Conclusions  These two cases illustrate that EPC can have a variety of presentations and can occur in African Americans. Although there is no standard of care for treating EPC, Mohs is becoming a common technique of removing these lesions.
Clinical features of Behçet's disease in children
Authors: Borlu Murat , Ukşal Ümit , Ferahbaş Ayten , Evereklioglu Cem 
Published: January 2006

AbstractBackground  Behçet's disease (BD) is a systemic inflammatory vasculitis of young adults with unknown etiology.Objective  The aim of this study was to determine the clinical features and outcome of BD in childhood.Patients and methods  Seventeen patients with BD within a pediatric age group were studied since 1997.Results  Boys : girls ratio was 12:5. Familial cases were very frequent (45%). Oral aphthous ulcers were present in all patients (100%), genital aphthous ulcers were present in 16 (94%), ocular lesions in 4 (24%), erythema nodosum in 3 (18%), papulopustules in 8 (47%), joint symptoms in 13 (76%), mild gastrointestinal symptoms in 2 (12%), neurological involvement in 2 (12%), positive pathergy reactions in 13 (76%), and thrombophlebitis in 1 (6%). We used colchicine, systemic corticosteroids, cyclosporine, nonsteroidal anti‐inflammatory drugs, sulfasalazine, and topical agents for the treatment of children with BD.Conclusion  The findings of BD in children are similar as in adults, but the frequency of familial cases is significantly higher.
Diagnostic accuracy in skin cancer clinics: the Australian experience
Authors: Moffatt Cameron R. M. , Green Adèle C. , Whiteman David C. 
Published: January 2006

AbstractBackground  Australia, with the world's highest incidence of skin cancer, has witnessed the emergence of “open access” skin cancer clinics during the past decade. These clinics are becoming increasingly popular destinations for the diagnosis and treatment of skin cancers, yet little is known about the diagnostic performance of practitioners in this setting. We sought to measure the accuracy of clinical diagnosis in this setting.Methods  Clinical and histological data were obtained from 199 consecutive patients undergoing biopsy or excision for 287 skin lesions. We measured the sensitivity, specificity and predictive value of the clinical diagnoses compared with histological diagnoses.Results  Of 287 biopsied or excised lesions, the most common were benign nevi (24%) and basal cell carcinomas (22%), followed by actinic keratoses (11%), dysplastic nevi (11%) and squamous cell carcinomas (7%). Sensitivity was highest for diagnosing BCC (0.89, 95%CI 0.78–0.95) and dysplastic nevi (0.80, 95%CI 0.61–0.93), and lowest for actinic keratoses and the group of benign lesions. Specificity was greater than 0.93 for all diagnoses except BCC (0.76, 95%CI 0.70–0.81). Treating clinicians perceived moderate to strong pressure to excise 49% of lesions overall, but in particular for benign nevi (73%).Conclusions  Australian family practitioners in open access skin cancer clinics diagnose a wide range of skin lesions with high specificity and moderate to high sensitivity. Benign nevi are accurately diagnosed and often excised because of patient pressure.
Genital lymphangioma with recurrent cellulitis in men
Authors: Swanson David L. 
Published: January 2006

AbstractBackground  Lymphangioma circumscriptum rarely occurs on the penis. This report describes a patient observed in private practice who presented with recurrent unexplained cellulitis of the penis for whom this diagnosis was not initially apparent.Methods  Diagnosis of lymphangioma in this patient resulted in a retrospective records review of the Mayo Clinic experience with patients who had genital lymphangioma and cellulitis.Results  Six other male patients with recurrent cellulitis complicating genital lymphangioma were identified. Five of these six patients were managed with antibiotic prophylaxis.Conclusions  Compromised lymphatic drainage should be suspected in male patients with otherwise unexplained penile swelling or cellulitis. These patients usually require long‐term antibiotic prophylaxis for recurrent infection.
A bibliometric study of dermatology in central Europe 1991–2002
Authors: Jemec Gregor B. E. , Nybæk Hanne 
Published: January 2006

AbstractBackground  Bibliometric studies have gained interest in recent years, although most analyses are limited to simple use of average citations rates for journals, also known as the “impact factor”. Central Europe has a long tradition of dermatological research which has been negatively impacted by general political developments for a long period. This study was undertaken in order to describe the progress made in recent years.Methods  The study was conducted in two parts: First the annualised national output for the period 1991–2002 was identified for each country by MEDLINE® searches. In the second part of the study a sample was drawn from the papers identified in the first part and the number of citations for each paper noted.Results  The annualised national output showed great variation between countries and from year to year. The mean citation rates were found to vary between 0–5 citations/year, and some underlying publications were 10 years old. Countries with national indexed journals appear to hold a bibliometric advantage over countries without indexed journals.Conclusions  Throughout the last decade of the 20th century the number of publications has grown with an average of 21.7% per year, and publication rates have only suffered in countries directly involved in war or similar disturbances. The mean citation rates were low, with a varying age of the underlying publications. Some cited publications were however old suggesting a persistent relevance. A national or regional indexed journal appears to confer a bibliometric advantage.
Training and disseminating family interventions for schizophrenia: developing family intervention skills with multi‐disciplinary groups
Authors: Fadden Gráinne 
Published: January 2006

AbstractFamily interventions for psychosis are not routinely available, in spite of a robust evidence base, clear policies and guidelines, and requests from service recipients. The reasons for this are complex involving three key groups: service recipients, clinicians and organizations. This paper first of all identifies barriers to implementation in relation to each of these groups. It then outlines a range of strategies that may be employed at a number of levels to bring about change in each of these systems. The strategies are drawn from current research in the area, and from experiences over a seven‐year period in the Meriden West Midlands Family Programme.
Family interventions in schizophrenia: evidence for efficacy and proposed mechanisms of change
Authors: Kuipers Elizabeth 
Published: January 2006

AbstractFamily intervention for psychosis developed from empirical work on the role of emotion in families of those caring for someone with schizophrenia. The level of expressed emotion (EE) has been shown to be a robust predictor of subsequent outcome for service users returning to live in family settings. There is also evidence that staff have similar attitudes. This has led to the development of specific family interventions for schizophrenia. NICE Guidelines for Schizophrenia (2003) confirm that family intervention is effective at reducing service user relapse rates and recommends it for those in contact with carers. Exactly how family intervention improves outcome is less clear. A recent model of psychosis proposes a primarily emotional rather than cognitive route for family factors, and some evidence is presented which supports this. Implications for family interventions are discussed.
Large aberrant Mongolian spots coexisting with cutis marmorata telangiectatica congenita (phacomatosis pigmentovascularis type V or phacomatosis cesiomarmorata)
Authors: Torrelo A , Zambrano A , Happle R 
Published: January 2006

AbstractA 1‐month‐old boy showed cutis marmorata telangiectatica congenita (CMTC) involving a block‐like pattern on his left leg and thigh and on the left side of his trunk, along with bilateral greyish‐blue hyperpigmentation involving the buttocks and thighs and being in part intermingled with CMTC. This association of CMTC with Mongolian spots has been reported as a distinct type of phacomatosis pigmentovascularis (PPV), namely PPV type V. More recently, the term phacomatosis cesiomarmorata (cesius = blue) has been proposed. We believe phacomatosis cesiomarmorata is another example of twin spotting or didymosis.
High‐resolution epiluminescence colorimetry of striae distensae
Authors: Hermanns J‐F , Piérard GE 
Published: January 2006

AbstractBackground  Colours of striae distensae are often different from that of the surrounding skin. A close look using dermoscopy discloses distinct patterns of melanized networks at these sites. The aim of the study was to design a method of high‐∖resolution analytical analysis of the skin colours using the combination of photographic dermoscopy and small field reflectance colorimetry.Methods  Clinical photographs were taken from striae distensae and their surrounding skin using a Dermaphot® (Heine Optotechnik, Hersching, Germany). A final magnification of 125× was obtained on paper photographs. The reflectance colorimeter Visi‐Chroma VC‐100 (Biophotonics, Lessines, Belgium) was used to measure colours of the pigmentary networks in the L*a*b* system. Differential colour parameters (ΔE*ab, ΔL*, Δa*, Δb*) were calculated for each case between the lesional and the surrounding normal skin, and between the melanized reticulated pattern and the enclosed lighter areas.Results  Objective colorimetric assessments distinguished four distinct types, namely striae albae, striae rubrae, striae caeruleae and striae nigrae. The latter peculiar hyperpigmented type of striae distensae was specifically identified by epiluminescence examination in dark‐skinned subjects. The fine‐melanized honeycomb network present on the adjacent intact skin was reshaped inside striae in a streaky pattern perpendicular to the striae axis. Strong linear correlations were found between all combinations of ΔL* and Δb* evaluating colours of the reticulated and the honeycomb alveolar patterns both inside and outside the striae distensae. By contrast, no correlations were found between Δa* and the other colorimetric parameters.Conclusion  The direct and/or indirect influences of melanocyte mechanobiology appear to have a prominent effect on the various colours of striae distensae.
Matting of hair: what is the role of conditioners?
Authors: Rigopoulos D , Kontochristopoulos G , Kalogirou O , Gregoriou S , Katsambas A 
Published: January 2006

AbstractMatting of the hair is a very rare and multifactorial condition affecting usually women. We present three female patients with matting of the hair as a result of the shampoo used. In all three cases, cutting of the affected hair was unavoidable.
A set of microsatellite markers for Heliconius melpomene and closely related species
Authors: MAVÁREZ J. , GONZÁLEZ M. 
Published: January 2006

AbstractThe butterflies in the genus Heliconius offer an exceptional opportunity for the study of the ecology and genetics of an adaptive radiation due to their extensive intra‐ and interspecific variation in wing colour patterns and mimetic associations. Here, we characterize 22 polymorphic microsatellite loci in Heliconius melpomene that have been shown to be useful for linkage mapping and population studies in this and other species. Levels of variation were high, although heterozygosity deficiencies were found in most loci, probably due to null alleles. The loci showed broad amplification success on six other species across the genus.
Being seen by others as we see ourselves: the congruence between the ingroup and outgroup perceptions of health and social care students
Authors: Hean Sarah , Clark Jill Macleod , Adams Kim , Humphris Debra , Lathlean Judith 
Published: January 2006

AbstractThis article examines intergroup processes amongst neophyte health and social care students who are about to embark on an interprofessional education (IPE) programme. Positive relationships between students of the different professions must be optimized to promote student learning of each other, a central objective of these courses. It has been proposed that to reduce conflict and promote harmonious intergroup relations during this IPE activity, students from each professional group should feel their own group (the ingroup) to be distinctive from other professional groups (the outgroup) on some key characteristics (intergroup differentiation). Good relations are further promoted if the characteristics they see as distinctive to their identities are also recognized as distinctive by other professional groups (mutual intergroup differentiation). The current article considers the incidence of these two factors in neophyte health and social care students and identifies sources of potential intergroup conflict. The findings of the study suggest that all groups of neophyte health and social care students perceived their ingroup as distinct from other professional groups, with the exception of audiology students. The implications of this finding to the relationships between students participating in IPE are discussed. Furthermore, in certain groups there was evidence that students of these groups were seen by others as they saw themselves. This was particularly the case for doctors and social workers and implies that these professions will suffer least from a threat to their group distinctiveness. However, there were instances where characteristics, seen as distinctive by the professional group itself, were not recognized by other groups. For example, physiotherapy students believe that being a team player, and decision making and practical skills were all distinctive characteristics of their profession. However, these features were not recognized as distinctive by other professional groups. The implications of matches/mismatches in how students see themselves, and how they may be viewed by others, are discussed in terms of their impact on student learning experiences and relationships during IPE.
Self‐assessment as a strategy to provoke integrative learning within a professional degree programme
Authors: Fitzpatrick Jane 
Published: January 2006

AbstractSelf‐assessment is advocated as a means of encouraging learners to develop critical thinking skills. This article examines how self‐assessment has been used within a community nursing programme to provoke learners’ integration of personal and professional development and thus extend their critical perspectives on their developing practice. The article explores how self‐assessment, combined with a culture of reflective dialogue within learner‐led discussion groups, enhances learners’ emotional engagement with learning. It suggests that self‐assessment, used as the focus of interactive learning experiences, can provoke integrative learning within a professional degree programme. By legitimately bringing personal and professional knowledge and skills acquisition to the fore, learners engage in challenging reflective dialogue with tutors, peers and mentors in practice. The article argues that this provides a pivot for transformative learning. This report draws on the evaluation of the self‐assessment strategy within a community nursing programme to illuminate the discussion. The evaluation draws on Joyes’ model of evaluation to include a review of both the process of, and stakeholder perspectives on, the development and implementation of the initiative. The community nursing case study suggests that self‐assessment can help harness emotion to benefit learning.