bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutis marmorata teleangiectatica congenita with segmental distribution
Authors: Boehncke Wolf‐Henning , Zollner Thomas Matthias , Kaufmann Roland 
Published: July 2006

AbstractCutis marmorata teleangiectatica congenita (CMTC) is a very rare vascular malformation closely related to port wine stains. It is present at birth, asymmetrical distribution and limb involvement are common. We report here on a 6–month‐old female patient exhibiting the typical clinical appearance of CMTC in a segmental pattern. To date 10 such cases have been reported. CMTC must be distinguished from other vascular malformations with asymmetrical distribution and – in case of a segmental pattern – particularly from unilateral dermatomal superficial teleangiectasia. Because of the tendency of such naevi to spontaneous improvement and localization of vascular dilatations in the dermis and subcutis no treatment was initiated at this point in lime.
Atopic dermatitis
Authors: Bos J.D. , Sillevis Smitt J.H. 
Published: July 2006

Abstract General description Atopic dermatitis is a common disease with a genetic background known as atopic syndrome. New findings as to possible genes involved are in accordance with a suspected pathogenesis of immune dysregulation. A preferential outgrowth of IL‐4 secreting Th2 cells upon stimulation with relevant allergens results in B cell stimulation and the production of allergen‐specific IgE. Non‐specific and specific immunological and inflammatory processes form the pathological basis of the clinical condition eczema. Therapeutical options include general measures such as allergen avoidance, prescription of emollients, and the use of (sedating) antihistamines. Specific topical agents are tar preparations, corticosteroids and possibly topical non‐steroidal anti‐inflammatory drugs. Systemic therapy is sometimes required and corticosteroids and cyclosporin are available for that purpose. Photo(chemo)therapy is another modality and long‐wave UVA seems to be promising in that respect. Learning objective The reader will have knowledge of new developments in the genetics and immunopathology of atopy and atopic dermatitis. Knowledge of the imniunodiagnosis and management of atopic dermatitis as well as its complications will be reviewed and updated with insights in new therapeutic modalities as well as in the changes of how the existing modalities should be used.
Vulvodynia: evolution of classification and management
Authors: Ridley C.M. 
Published: July 2006

AbstractThe aim of this article is to make the reader familiar with the history and current status of vulvodynia. The account is presented as a historical survey, from the seventies to the nineties. It explains how and why the term came to be defined, and how some sub‐groups – in particular dysaesthetic vulvodynia and vulval vestibulitis – have been identified and described. Their management is discussed. The importance of distinguishing these conditions from those which are variants of normal is stressed.It is noted that these sub‐groups have much in common, so that a degree of convergence or overlap has come to be recognised. In parallel with this, ideas concerning aetiology and optimal management have been clarified and are explored.Appreciation of the present state of affairs, and of how it has been arrived at, will help to improve management. It will also facilitate the collection of data, which in turn may lead to further research and understanding of vulvodynia.
Influence of calcitonin on eicosanoid serum levels in the treatment of patients with systemic sclerosis
Authors: Gruschwitz Matthias S. , Collenberg Claudia , Albrecht Hans‐Peter 
Published: July 2006

Abstract Background Treatment of scleroderma (systemic sclerosis. SSc) patients (stages I‐III) with intravenous (i.v.) calcitonin for 10 days (100 IU/day, Karil®, Sandoz AG, Germany) 3 times/year leads to subjective and objective improvement of microcirculatory parameters determined by Laser‐Doppler fluxmetry and cutaneous pO2 (pcuO2) measurement. Aim As previously suggested some rheologic effects of calcitonin might be mediated by vasoactive metabolites of the arachidonic acid metabolism. Alterations of eicosanoid plasma levels were determined in 15 SSc patients during i.v. calcitonin therapy. Methods Peripheral blood was obtained on the 1st and 9th days of therapy during a 2 h intravenous calcitonin administration. Samples were taken after 45, 90, 135 and 160 min as well as 1, 5 and 19 days after therapy was stopped. Serum levels of 6‐keto‐prostaglandin F1α (6‐keto‐PGF), a stable end product of prostacyclin synthesis, prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and thromboxane B2 (TXB2) were determined by enzyme‐ or radio‐linked assays. Results In contrast to healthy controls we measured elevated 6‐keto‐PGF, LTB4 and PGE2 serum levels in SSc patients before i.v. treatment, whereas TXB2 levels showed no significant differences. Calcitonin administration led to an increase of plasma 6‐keto‐PGF after 45 min falling back to the starting level during further treatment as well as to a longer‐lasting increase of PGE2 on both the 1st and 9th days of therapy. Calcitonin treatment decreased LTB4, but did not influence TXB2 levels significantly during intravenous administration.ConclusionOur data suggest a compensatory mechanism of the damaged vascular system with respect to the PGI2 (prostacyclin) and PGE2 formation in SSc patients measured by a constant elevation of these vasodilatory metabolites. LTB 4 may be involved in the microvascular damage in SSc. Calcitonin administration leads to a short‐lasting elevation of 6‐keto‐PGF1α and an increase of PGE2 combined with a reduction of LTB4 resulting in longer‐lasting beneficial effects on microcirculatory functions in diseased skin. Since non‐steroidal anti‐in‐flammatory agents had no influence on long‐term vasoactive effects, improvement of microcirculatory properties by calcitonin may be additionally mediated by smooth muscle relaxation of arterioles.
Axillary apocrine adenocareinoma associated with pancreatic adenocarcinoma
Authors: Sevila Amparo , Botella Rafael , Silvestre Juan Francisco , Bañuls José , Massuti Bertomeu , Aranda Ignacio , Alfonso Remedios 
Published: July 2006

AbstractApocrine adenocarcinoma of the skin is a rare malignant tumor which usually presents as a single nodule in the axilla. A new case originating in the right axilla with bilateral axillary lymph node metastases is described. Six years later the patient developed a pancreatic adenocarcinoma. As far as we know this is the first lime that this association has been described.
Alopecia areata: unusual family history and successful therapy with DCP
Authors: Thewes Matthias , Engst Reinhard , Bressler Christina , Worret Wolf‐Ingo , Ring Johannes 
Published: July 2006

AbstractWe describe the case of a 25‐year‐old Caucasian female with alopecia areata (Aa) and a poor prognosis for hair regrowth with a 14‐year history of Aa, 1‐year duration of hairless areas of the scalp, multiple positive family history, history of atopy and a Hashimoto‐thyreoiditis. After 2 months of topical immunotherapy with diphenylcyclopropenone (DCP) hair regrowth appeared and after 6 months the regrowth was regarded as successful.
Pyoderma gangrenosum associated with ulcerative colitis and subcutaneous and splenic abscesses
Authors: Yamagata Masakazu , Kumano Kimiko , Ueda Masato 
Published: July 2006

AbstractPyoderma gangrenosum is a rare, chronic, inflammatory ulcerative skin disease of unknown etiology and pathogenesis. It is often associated with systemic disease. We describe a patient with pyoderma gangrenosum associated with ulcerative colitis and aseptic abscesses of the subcutis and spleen, which have been rarely reported previously. These manifestations were cleared by combined therapy with minocycline hydrochloride and diaphenylsulfone.
Fascinating Womanhood as a Regression in the Emotional Maturation of Women
Authors: Rogers Martha L. 
Published: July 2006

“Fascinating womanhood” (Andelin, 1974) is explored as a response to anxiety generated by awareness of the potential for experiencing the self as a separate, responsible person. Such a response represents regression and offers only temporary reprieval from personal and/or marital distress. Clinical experiences are related to this concept; observations suggest that the solution formalized by Andelin is unsatisfactory. A therapeutic approach that can be utilized in encouraging optimal individuation is discussed, with group, marital, and individual therapy examples. A sequence of predictable responses to therapeutic confrontation has been identified, along with indicators for evaluating progress or retreat from the process. Precautions in the use of this approach are also discussed.
Contemporary Research on Hispanic Women: A Selected Bibliography of the Social Science Literature
Authors: Amaro Hortensia , Russo Nancy Felipe , Pares-Avila Jose A. 
Published: July 2006

One of the difficulties in developing a new area of research in any field is the lag time between the interest in the area on the part of researchers and the interest in publishing on the part of editors. Initial work may appear in books or publications outside the disciplinary mainstream and be overlooked in literature searches that focus on established journals. Further, work appearing in mainstream journals may be constrained by traditional paradigms and reflect Anglocentric and sexist biases of traditional research. This has been true for work on Hispanic women, which has been hallmarked by Anglocentric and sexist bias (Senour, 1977). This 134-item bibliography addresses the difficulty of identifying the diverse work on Hispanic women in the U.S. and Puerto Rico by bringing a large part of it together in one place. We have three goals. The first is to facilitate the integration of material on Hispanic women into the curriculum of psychology. The second is to promote and disseminate research on the psychology of Hispanic women. The third is to recognize contributions of early researchers who have pioneered in developing and articulating knowledge about this neglected group. We want to emphasize that this bibliography is not comprehensive. The focus is on scholarly work in the English language that advances understanding of Hispanic women's uniqueness and diversity as a group. Studies that included Hispanic women in their sample but did not specifically focus on Hispanic women or did not conduct gender or gender/ethnicity analyses were not included.
Leadership and Nonverbal Behaviors of Hispanic Females Across School Equity Environments
Authors: Moore Helen A. , Porter Natalie K. 
Published: July 2006

Nonverbal behaviors of Hispanic elementary school students and their peers were examined in a small-group cooperative task with a total of 202 subjects. Thirty-five randomly selected groups were videotaped in ten desegregated schools; each group was gender-homogeneous, with three Hispanic and three Anglo students. Analysis of the videotapes revealed that Hispanic females used less vertical and horizontal space than Anglo females, and were also less likely to verbally interrupt or physically intrude on other group members. They had similar rates of handling the group resource cards and were given similar leadership scores by multi-ethnic trained observers. Among males, Hispanics are significantly more likely to use vertical or upward movements and physical intrusions, while Anglos use more verbal interruptions. School and social status factors such as high- and low-equity desegregated school programs, ethnic and gender status, and school status variables of academic grades and English word knowledge had varying effects on teacher and peer ratings of leadership. High-equity schools garnered higher leadership scores for Hispanic females from both peers and teachers when all other nonverbal behaviors were controlled. This positive effect of the school on leadership ratings was evident only for males in teacher ratings. Hispanic females and their peers do reflect adult models of nonverbal behavior and leadership, and that leadership is enhanced in the perceptions of teachers and peers when they participate in a high-equity desegregated elementary school.
Review
Authors: Hall Ruth 
Published: July 2006

The Politics of Race and Gender in Therapy, Lenora Fulani (Ed.). New York: Hawthorne, 1988. 120 pp. $24.95. Psychotherapy With Lesbian Clients: Theory to Practice, Kristine L. Falco. New York: Brunner/Mazel, 1991. 208 pp. $26.95. Jewish Women in Therapy: Seen but Not Heard, Rachel Josefowitz Siegel and Ellen Cole (Eds.). New York: Hawthorne, 1991. 126 pp. $19.95, $9.95 (paper).
Reviews
Authors: Beyers Julie Miethke , Follingstad Diane R. , Breiter Heather D. , Marecek Jeanne , Cleveland Jeanette N. 
Published: July 2006

Career Counseling for Women, W. Bruce Walsh and Samuel H. Osipow (Eds.). Hillsdale, NJ: Erlbaum, 1994. 385 pp. $34.50 (paper). ISBN 0-8058-1401–9. It Could Happen to Anyone: Why Battered Women Stay, Ola W. Barnett and Alyce D. LaViolette. Thousand Oaks, CA: Sage, 1993. 184 pp. $38.00. ISBN: 0-8039-5310–0. Empowering and Healing the Battered Woman, Mary Ann Dutton. New York: Springer, 1992. 202 pp. $28.95. ISBN: 0-8261-7130–3. Breaking Destructive Patterns: Multiple Strategies for Treating Partner Abuse, Janet A. Geller. New York: Free Press, 1992. 182 pp. $27.95. ISBN: 0-02-911605–8. Against Therapy, Jeffrey Moussaieff Masson. Monroe, ME: Common Courage Press, 1988/1994. 340 pp. $15.95. ISBN 1-56751-022–1. Changing Our Minds: Lesbian Feminism and Psychology, Celia Kitzinger and Rachel Perkins. New York: New York University Press, 1993. 216 pp. $14.95. ISBN: 0-8147-4646–2. Cultures of Organizations. Three Perspectives, Joanne Martin. New York: Oxford University Press, 1992. 240 pp. $35.00. ISBN 0-19-507163–8.
Feminist Voices of Color: History, Identity, and Empowerment
Authors: Banks Martha E. 
Published: July 2006

African American Single Mothers: Understanding Their Lives and Families, Bette J. Dickerson (Ed.). Thousand Oaks, CA: Sage Publications, 1995. 200 pp., $48.00 (cloth), ISBN: 0-8039-4911-1; $24.00 (paper), ISBN: 0-8039-4912-x. Black Women in America, Kim Marie Vaz (Ed.). Thousand Oaks, CA: Sage Publications, 1995. 396 pp., $52.00 (cloth), ISBN: 0-8039-5454-9; $24.95 (paper), ISBN: 0-8039-5455-7. Understanding Latino Families: Scholarship, Policy, and Practice, Ruth E. Zambrana (Ed.). Thousand Oaks, CA: Sage Publications, 1995. 242 pp., $47.95 (cloth), ISBN: 0-8039-5609-6, $23.95 (paper), ISBN: 0-8039-5610-X.
Median Effect and Long Term Recovery Analysis of Biological Modifier Interactions With Difluoromethylornithine on the Proliferation of Human Melanoma Cells
Authors: BREGMAN MARVIN D. , BUCKMEIER JULIE , FUNK CAROLE , MEYSKENS FRANK L. 
Published: July 2006

The ability of difluoromethylornithine (DFMO), a specific polyamine synthesis inhibitor, to interact with various biological modifiers to inhibit the colony‐forming growth of human melanoma cells was determined by using the median effect principle to computer model the strength of two agent interactions. Either alpha‐ or gamma‐IFN (interferon) in combination with DFMO resulted in a synergistic inhibition on human melanoma colony formation. For human melanoma cells which were not resistant to 13‐cis RA (retinoic acid), an additive suppression on colony formation was obtained with the retinoid‐DFMO combination. Dexamethasone (DEX) interacted with DFMO to yield a synergistic reduction in melanoma colony number on glucocorticoid sensitive cells and no growth enhancement with DFMO on glucocorticoid resistant melanoma lines.Human melanoma cells displayed differential long‐term growth sensitivity to DFMO treatment. C8146C human melanoma cells were terminally growth‐inhibited by a 96 h exposure to DFMO, in a manner which was concentration and time dependent. The proliferation of C82‐7A melanoma cells was inhibited by 95% in presence of DFMO, but upon removal of DFMO the cells regained their ability to proliferate and form colonies. The simultaneous addition of DEX plus alpha‐IFN plus 13‐cis‐RA with DFMO caused most of the human melanoma cells in these lines to become permanently growth arrested. Pre‐treatment with DEX plus alpha‐IFN plus 13‐cis RA, but without DFMO, did not have any long term effect on the ability of melanoma cells to recover and proliferate in soft agar. Since human melanoma cells are heterogeneous with respect to sensitivity to these hormones, it may be advantageous to use DFMO with several of these agents in combination.
Specificity of Growth Inhibition of Melanoma by 4‐Hydroxyanisole
Authors: KULKARNI GAJANAN A. , NATHANSON LARRY 
Published: July 2006

An experimental study using human melanoma (NEL‐M1), rat hepatoma (Fu5‐5), and human kidney (293‐31) cell lines was undertaken in order to evaluate the antitumor activity of 4‐hydroxyanisole (4‐OHA) in vitro. Prior reports have indicated highly specific antitumor activity of 4‐OHA against melanoma cells in vitro. This specific antitumor activity has been proposed to be due to the oxidation of 4‐OHA by tyrosinase to cytotoxic oxidation products.Dose‐dependent cytotoxicity was observed when cells were cultured for 72 h in the presence of 4‐OHA. At 100 μM, 4‐OHA produced growth inhibition of 62%, 32%, and 55% in melanoma, hepatoma, and kidney cell lines, respectively. No effect was seen at 10 μM 4‐OHA. 1,000 μM 4‐OHA produced 100% kill. Tyrosinase activity was detected only in melanoma cells.The effect of 100 μM 4‐OHA on the incorporation of 3H DNA precursors in melanoma, hepatoma, and kidney cells was also studied. Thymidine incorporation was inhibited in all three cell lines at the lowest cell density tested, with the greatest inhibition seen on melanoma cells. As cell density increased, the effect of 4‐OHA on thymidine incorporation decreased. With respect to RNA synthesis, 4‐OHA significantly reduced the incorporation of uridine in all three cell lines, with the greatest effect in melanoma cells. Cell density also affected the inhibition of uridine incorporation, but to a lesser extent than that observed on thymidine incorporation. The effect of 4‐OHA on leucine incorporation was modest and uninfluenced by cell density.Thus, cytotoxicity of 4‐OHA may involve two different mechanisms. The first, predominating in melanoma cells, is mediated by tyrosinase, which converts 4‐OHA into cytotoxic products. The second (non melanoma cells) is independent of tyrosinase and involves inhibition of both RNA and DNA synthesis.
Present Status of the Medical Irradiation Facility at the Musashi Reactor
Authors: MATSUMOTO TETSUO , AIZAWA OTOHIKO , NOZAKI TETSUYA , SATO TADASHI 
Published: July 2006

Boron neutron capture therapy (BNCT) of malignant brain tumors has been efficiently performed since March 1977, and the first human case of malignant melanoma was also successfully treated on July 1987 in our reactor (Musashi reactor, TRIGA‐II, 100 kW).To obtain both good irradiation field characteristics and a better irradiation facility, some tests and developments have been continued in accordance with the study of medical and biological irradiations. The results of these evaluations and a new approach are presented.
Optimization of Boron and Neutron Delivery for Neutron Capture Therapy
Authors: FAIRCHILD R.G. , SLATKIN D.N. , CODERRE J.A. , MICCA P.L. , LASTER B.H. , KAHL S.B. , SOM P. , FAND I. , WHEELER F. 
Published: July 2006

A number of groups in the United States have received funding that will permit evaluation of the clinical efficacy of the neutron capture therapy (NCT) procedure. Various reactors are being modified to allow the construction of an epithermal neutron beam.At the Brookhaven Medical Research Reactor (BMRR), the patient irradiation facility is being modified to produce an optimized epithermal neutron beam. An 80‐cm‐thick Al‐D2O mixture (184 g/cm2, 25% D2O by volume) is being installed in the shutter assembly. One‐dimensional calculations indicate that this configuration should provide an epithermal neutron flux density of ∼1 × 109 n/cm2/sec at 3 MW and a concomitant fast neutron dose rate of ∼2 × 10−11 rad per epithermal neutron (assuming a homogeneous Al‐D2O mixture). The actual geometry will be an inhomogeneous array of D2O and Al layers producing parameters somewhat less favorable than those listed above; experimental verification is in progress.Significant gains have recently been made in selectively targeting B to melanoma with various melanaffinic compounds, including p‐boronophenylalanine, and with boronated porphyrins that may be applicable to a variety of tumors. Neutron capture radiographs have been obtained with the above compounds, and efforts have been made to quantitate boron uptake in growing and quiescent or necrotic regions of tumor via double‐labeling techniques obtained with tritiated thymidine. A correlation between therapeutic efficacy and the ability to deliver boron to viable areas of tumor has been observed.
Ionic Requirements for Catecholamine Aggregating Actions on the Teleost Poecilia reticulata Melanophores
Authors: VISCONTI MARIA APARECIDA , CASTRUCCI ANA MARIA DE LAURO 
Published: July 2006

Norepinephrine (NE) and phenylephrine (Phe) were employed to study the ionic requirements for alpha adrenoceptor activation in the teleost Poecilia reticulata melanophores.As expected the beta adrenoceptor blocker, propranolol, increased the sensitivity of the preparation to NE (5.8 times), and was therefore employed in all the experimental procedures. Neither cocaine (a neuronal uptake blocker) nor dexamethasone (an extraneuronal uptake blocker) enhanced the sensitivity of the preparation to NE, suggesting that these inactivating mechanisms would not play a role in P. reticulata pigmentary system. However, in the absence of calcium, the dose‐response curve (DRC) to NE was displaced to the left about 3.5 times, whereas the DRC to Phe was not affected. These results indicate that a neuronal uptake is active, but was not demonstrated by the classical pharmacological tools, probably due to an assymmetric display of the nervous endings.The DRC to NE was rightward displaced (14.1 times) in the presence of the calcium channel blocker Verapamil, whereas the DRC to Phe was not affected. These data suggest that P. reticulata melanophores possess a mixed population of alpha1 and alpha2 adrenoceptors, the activation of the latter eliciting an extracellular calcium influx.In sodium‐free saline, the DRC to NE was rightward shifted (6.6 times) and the response to Phe was impaired in such a way that the maximal response was not achieved. The DRC to both NE and Phe were rightward displaced (7.9 and 2.7 times respectively) in the presence of the sodium channel blocker tetrodotoxin (TTX) 10−7M.In potassium‐free saline, the melanophore sensitivity to Phe was increased, whereas the responses to NE were not affected, suggesting a differential sensitivity of the two alpha adrenoceptor subtypes to the resulting membrane hyperpolarization.Based on the literature and on our data we propose that P. reticulata melanophores possess a mixed population of alpha1 and alpha2 receptors. The activation of both subtypes of alpha adrenoceptors elicits a Na+ ion influx through TTX‐sensitive sodium channels. The stimulation of alpha2 adrenoceptors also requires an extracellular calcium influx, through the opening of slow calcium channels.