bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of liver involvement in Hodgkin's disease
Authors: Pittman C. Edwin , Buss David H. , Sterchi J. Michael 
Published: February 2007

AbstractLiver involvement with Hodgkin's disease is determined at our institution by a combination of wedge biopsy and needle biopsy at the time of staging laparotomy. This retrospective study was undertaken to determine whether the wedge or the needle biopsy method is the more accurate. All staging laparotomies (n = 116) during the period 1972–1986 were reviewed. Twelve patients were found to have liver involvement with Hodgkin's disease; 2 had had wedge biopsies only and ten had had both wedge and needle biopsies. In all ten with both wedge and needle biopsies, the wedge biopsies were positive for liver involvement, but in only five were the needle biopsies positive. This study indicates that wedge biopsy is the more accurate method for detecting liver involvement in these patients, and we believe it should always be a part of the staging laparotomy for Hodgkin's disease.
Malignant fibrous histiocytoma (MFH) arising within a cholecystectomy incision: A cause‐and‐effect relationship is possible between previous surgery and the development of a malignant fibrous histiocytoma within the operative site
Authors: Spirtos George , Qadri Alam , Phillips Alexander K. 
Published: February 2007

AbstractWe present a report of a patient who, after an uneventful cholecystectomy, developed an incisional mass that proved to be a malignant fibrous histiocytoma and had to be excised. Five months later, the patient developed a similar incisional mass, which was shown to be a malignant fibrous histiocytoma and again had to be excised. The rarity of such a case and the details of the patient's case history are reported. The implications of a possible relationship between previous surgery, the patient's healing response, and the development of these tumors are discussed.
Radiographic evaluation for pulmonary metastases in sarcoma patients
Authors: Duda Rosemary B. , Beatty J. David , Kokal William A. , Riihimaki Daniel U. , Terz Jose J. 
Published: February 2007

AbstractThe records of 130 patients with soft tissue and bone sarcomas were retrospectively analyzed to identify the subgroups of patients that would benefit from tomographic studies for pulmonary metastasis. Sixty‐six of 96 patients with a normal conventional chest roentgenogram (CXR) had tomography to diagnose pulmonary metastasis. Of the 53 patients who had primary disease and a normal CXR followed by tomography, only 1 (1.9%) had metastases identified on tomograms. Of the 13 patients who had locally recurrent sarcoma and a CXR plus tomographic studies, 2 (15%) had metastases detected on tomogram only. Tomographic studies detected significantly more sarcoma patients with pulmonary metastasis in the group with locally recurrent disease than in the group with primary disease (P < 0.05).
Lateral high abdominal ovariopexy: An original surgical technique for protection of the ovaries during curative radiotherapy for hodgkin's disease
Authors: Gaetini A. , De Simone M. , Urgesi A. , Levis A. , Resegotti A. , Ragona R. , Anglesio S. 
Published: February 2007

AbstractAn original surgical method for gonadal protection in young women given pelvic radiation for Hodgkin's disease is presented. Lateral high ovarian transposition (LHAO) consists of the transposition of the ovaries into the paracolic gutter during staging laparotomy, after disconnecting the gonads from the fallopian tubes by dividing the tubo‐ovarian vessels.The technique's effectiveness was assessed by a study using clinical investigation, radioimmunoassay (RIA) determination of sex hormones, and dosimetry; of 18 patients treated, 10 participated in the study. All but one have normal menses and hormone values, and one pregnancy occurred. We also calculated the doses absorbed by the ovaries and proved that, during inverted Y irradiation following LHAO, the ovaries are exposed to nearly one‐half the dose they receive after traditional medial transposition. During subtotal nodal irradiation after LHAO, the irradiation dose is higher than after medialisation, but absolute values are minimal and castration is not induced.
Results of liver angiography and perfusion scintigraphy do not correlate with response to hepatic artery infusion chemotherapy
Authors: Lehner B. , Kretzschmar U. , Bubeck B. , Holting T. , Schlac P. 
Published: February 2007

AbstractLiver angiography and liver perfusion scintigraphy with Tc‐99m‐labeled macroaggregated albumin (MAA) were performed in 36 patients with liver metastases from colorectal cancer prior to continuous 5‐fluorouracil hepatic artery infusion (HAI) hemotherapy. Of the 26 patients showing metastases on arteriogram, five revealed increased tumor vascularisation, five had normal vascularisation, and 16 showed decreased vascularisation of the metastases relative to liver. In liver perfusion scintigraphy, 15 of the 36 patients showed increased perfusion of the metastases, four had normal perfusion, and 17 had decreased tumor perfusion. The observed differences in survival in the different groups were not statistically significant: patients survived 15 months in the group with increased tumor vascularisation, 8 months for normal vascularisation, and 14 months for decreased tumor vascularisation; survival was 28 months for the group of increased, and 13 and 14 months for the normal and decreased tumor perfusion groups respectively. Also, response rates with 80%, 40%, and 75% responders in the group of increased, normal, and decreased tumor vascularisation, respectively, and 80%, 50%, and 59% responders in the group of increased, normal, and decreased perfusion, respectively, were not significantly different. These results indicate that there is no possibility to discriminate potential responders from nonresponders by results of liver angiography or perfusion scintigraphy.
Prognostic value of hormone receptors in breast cancer
Authors: Morimoto Tadaoki , Komaki Kansei , Yamamoto Hiroyuki , Yamakawa Takashi , Tanaka Takashi , Sonoo Hiroshi , Monden Yasumasa 
Published: February 2007

AbstractThe aim of this study was to establish the role of estrogen receptor (ER) and progesterone receptor (PgR) as prognostic indicators for early recurrence and survival. In all, among breast cancer patients, 166 patients who had undergone radical or extended radical mastectomy were studied. These patients were treated with adjuvant chemotherapy alone for 2–3 years after surgery. No patients had adjuvant endocrine therapy. Local recurrence and/or distant metastases were treated by endocrine therapy and/or chemotherapy. The relapse‐free interval was not different between the ER‐positive and ER‐negative patients. The postrelapse survival curve was significantly different between the two groups. There was no significant difference in the relapse‐free interval and the postrelapse survival curve between the PgR‐positive and PgR‐negative patients. These results suggest that ER is a good predictor of the response to endocrine therapy given after relapse, but not of early recurrence.
Immunohistological characterization of human monoclonal antibody against lung cancer
Authors: Yano Tokujiro , Yasumoto Kosei , Nagashima Akira , Murakami Hiroki , Hashizume Shuichi , Nomoto Kikuo 
Published: February 2007

AbstractUsing immunoperoxidase staining method, a human monoclonal antibody (MAb), termed HB4C5, which was generated by fusion of NAT‐30 cells with regional lymph node lymphocytes from a lung cancer patient, was examined for tumor specificity. The determinant recognized by HB4C5 MAb was well preserved in usual formalin‐fixed paraffin‐embedded tissue sections. Experiments with four major histological types of the lung cancer showed that HB4C5 MAb reacted with adenocarcinoma (19/27), squamous cell carcinoma (2/15), and large cell carcinoma (4/6), but not with small cell carcinoma (0/7). The immunoreaction was seen in the cytoplasm. In addition, this MAb also reacted with some gastric and colon adenocarcinomas. Further study on normal lung and nonpulmonary tissues revealed that HB4C5 MAb bound only type II pneumocytes and proximal tubules of normal kidney.
Radiotherapy and l‐triiodothyronine in the treatment of high‐grade astrocytoma
Authors: Morales Pedro , Bosch Antonio , Lopez Ricardo , Nery Cristina , Borras Freddy , Rosa Mario 
Published: February 2007

AbstractFrom January 1983 to March 1984, eight patients with high‐grade astrocytoma received postoperative irradiation concomitantly with triiodothyronine at the Radiation Therapy Department of the I. González Martínez Oncologic Hospital in San Juan, Puerto Rico. There were no complications related to treatment. One patient is alive without evidence of disease at 39 months and seven patients died with disease, one of whom lived for 3 yr. The survival curve for these patients is similar to the survival curve of 18 patients treated at the University of Chicago by surgery, radiation, and triiodothyronine. The value of triiodothyronine as an adjuvant in the treatment of high grade astrocytoma should be further investigated.
Relationship of surveillance cultures to bacteremia and fungemia in bone marrow transplant recipients with hickman or broviac catheters
Authors: Rotstein Coleman , Higby Donald , Killion Kathleen , Powell Eileen 
Published: February 2007

AbstractA total of 64 episodes of bacteremia and fungemia were documented in 25 allogeneic bone marrow transplant recipients. Coagulase‐negative staphylococci were the most common pathogens recovered, with 34 of the 39 isolated being methicillin resistant. Streptococcus viridans (11 episodes), diphtheroids (5 episodes), and Pseudomonas aeruginosa (4 episodes) accounted for the majority of the other pathogens causing bacteremia. Six episodes of fungemia were also seen. Coagulase‐negative staphylococci were demonstrated in 31 of 36 (86%) throat cultures, 25 of 35 (71%) stool cultures, and 6 of 7 (86%) Hickman or Broviac catheter exit site surveillance cultures prior to the development of bacteremia caused by these organisms. Throat surveillance cultures positive for 5. viridans also showed a correlation (88%) with subsequent S. viridans bacteremia. However, surveillance cultures for aerobic gram‐negative bacilli, diphtheroids, and fungi did not correlate with subsequent septicemia. Organisms isolated in throat surveillance cultures correlated with subsequent bacteremia caused by these organisms in only 15% of all the cultures taken, while only 14% of stool cultures predicted bacteremia. The utility of surveillance cultures is limited because of low cost‐effectiveness and a high rate of false‐positive results.
Effect of blood transfusions on immune function: IV. Effect on tumor growth
Authors: Paul Waymack J. , Chance William T. 
Published: February 2007

AbstractBlood transfusions have previously been shown in retrospective studies of oncologic surgical patients to be associated with an increased incidence of tumor metastases and decreased long‐term survival rate. The possibility that these findings were due to patients with larger, more aggressive tumors requiring the transfusions could not be excluded. To eliminate this possibility, the effect of transfusions on tumor growth in a rat sarcoma model was tested. In this study it was shown that allogeneic transfusions increase the rate of tumor growth and decrease mean survival times. This effect was not demonstrated when syngeneic transfusions were used. These data indicate that the diminished long‐term survival seen in transfused patients undergoing tumor resection may be due to an impaired immunologic response to the tumor. Avoidance of this effect might be possible through the use of human syngeneic (autologous) transfusions.
Fibrolamellar carcinoma of the liver in the orient
Authors: Yoshida Kazuhiko , Amemiya Atsushi , Kobayashi Susumu , Sakurai Kenji , Suzuki Masaki , Aizawa Sigeru 
Published: February 2007

AbstractWe describe, in a 56‐year‐old man, the first case of fibrolamellar carcinoma of the liver (FCL) in the Orient. Contrary to patients seen in the Western world, our patient has many characteristics of ordinary hepatocellular carcinoma seen in the Orient, i.e., middle age, male, HBsAg carrier, elevated α‐fetoprotein, presence of HBsAg in the hepatocytes, and chronic hepatitis. These clinicopathological findings suggest a possible relationship between exposure of HB virus and FCL.
Perioperative blood transfusion and colorectal cancer recurrence: A review
Authors: Tartter Paul Ian 
Published: February 2007

AbstractRetrospective studies of the relationship between perioperative blood transfusion and colorectal cancer recurrence are reviewed. Perioperative blood transfusion was associated with preoperative anemia, operations for rectal carcinoma, presence of tumor in the right colon, prolonged procedures, and copious blood loss. Control for variables related to blood transfusion and potentially affecting disease recurrence—blood loss, duration of surgery, and magnitude of the procedure—was notably absent from the majority of studies. None of the negative studies had sufficient numbers of both transfused and untransfused patients to reject the hypothesis that blood transfusion is associated with cancer recurrence with statistical validity. No concensus emerged regarding the significance of blood transfusion for the patient with colorectal cancer, and no recommendations concerning the use of blood are justified on the basis of these studies.
Selective effect of doxorubicin suspended in lipiodol on VX2 carcinoma in rabbits
Authors: Furuta Toshiya , Kanematsu Takashi , Kakizoe Saburo , Sugimachi Kiezo 
Published: February 2007

AbstractWhen Lipiodol Ultra‐Fluid (Lipiodol) was given through arteries feeding the tumor, this material was retained in the tumor. After mixing Lipiodol and doxorubicin (adriamycin; ADR), the effect of this antitumor agent on VX2 carcinoma inoculated into the hindlimb in 57 rabbits was investigated. Size of the tumor remarkably decreased in the rabbits treated with ADR 2 mg/kg suspended in Lipiodol and given through the femoral artery. Intraarterial injection of ADR 2 mg/kg alone led to a transient decrease in size of the tumor, but there was a regrowth. The result was comparable to a finding in a group in which half the dose of ADR (1 mg/kg) suspended in Lipiodol was given intraarterially. When ADR 2 mg/kg mixed with Lipiodol was injected directly into the tumor, growth of the tumor was not completely inhibited. Lipiodolized ADR has a prominent antitumor effect, and Lipiodol has the potential to be applied as a carrier of anticancer drugs.
Primary carcinoma of the gallbladder: TNM staging and prognosis
Authors: White Keith , Kraybill William G. , Lopez Marvin J. 
Published: February 2007

AbstractIn order to investigate the lethality of carcinoma of the gallbladder and several of the coexisting features, a retrospective analysis of 53 patients with this disease was undertaken. Abdominal pain, obstructive jaundice, and a right upper quandrant mass were present in approximately one‐half of the patients. Laboratory and radiological data were frequently nonspecific and did little to identify the diagnosis. The most common preoperative diagnoses were cholelithiasis or chronic cholecystitis. Cholecystectomy was the most frequently performed procedure. Fifteen wedge liver resections were performed. No radical or extended liver resections were done. Eighty‐one percent of the patients had sufficient data for staging. Five patients (11.6%) had stage I lesions, three patients (7.0%) had stage II lesions, while 17 (39.5%) and 18 (41.9%) patients had stage III and IV lesions, respectively. Mean survival was 6.4 months for the entire group. Three patients are still alive (two longer than 5 years and one at 2 years) for an overall survival of 5.7%. Both staging and grading of the tumor correlated well with patient survival. Those patients with stage I lesions survived significandy longer (23 months vs. 3 months) than those with stage IV tumors. Also, those with more favorably graded (well‐differentiated) neoplasms lived an average of 13 months longer than patients with poorly differentiated lesions.
Tolerance of rat testis to graded periods of total circulatory isolation
Authors: Lui Raphael C. , Laregina Marie C. , Herbold David R. , Johnson Frank E. 
Published: February 2007

AbstractInfertility because of testicular damage is a distressing problem for survivors of cancer chemotherapy. We have previously described a cytoprotective effect of temporary testicular circulatory isolation (TCI) during doxorubicin administration in the rat. In this report we define the relationship between duration of TCI and testicular ischemie injury, using paired groups of animals with normothermic TCI and hypothermie TCI. Sixty rats were used and received TCI for varying lengths of time up to 180 minutes, with or without hypothermia. On day 56 ± 4, all rats were killed and necropsied. Testicular injury was evaluated qualitatively by histology and quantitatively by testicular weight, sperm head count, repopulation index, and epididymal index. Warm TCI for up to 60 minutes induced modest damage to germ cells, while injury was greater with cold TCI. Leydig cells and vascular tissues were essentially unaffected by TCI, although Sertoli cell abnormalities were noted in rats receiving a long duration of TCI.
Application of the immunoperoxidase method for rapid intraoperative pathological diagnosis of pancreatic cancer
Authors: Ichihara Tohru , Nakao Akimasa , Sakamoto Junichi , Nonami Toshiaki , Harada Akio , Watanabe Tadashi , Takagi Hiroshi , Nagura Hiroshi 
Published: February 2007

AbstractIntrapancreatic extension of pancreatic duct cell carcinoma in 19 resectable cases was evaluated by both hematoxylin and eosin (H&E) staining and quick immunostaining using antibodies against cancer‐associated antigens —e.g., CA19‐9, DUPAN 2, and CEA—on the intraoperative frozen‐section biopsy during the course of laparotomy. By H&E staining, malignant lesions were identified in four of 19 cases (21%). By the immunostaining method, however, cancer cells were detected in 10 of 19 cases (52.6%). This immunostaining method was particularly useful in defining cancer cells surrounded by dense fibrous connective tissue, in which cancer cells are usually difficult to evaluate by H&E staining. Thus, the application of such immunostaining, together with H&E staining, on the cryostat sections of biopsy specimens may provide important information for the appropriate operative method. Retrospective study of permanent sections revealed that pathological diagnosis by quick immunostaining was more accurate than diagnosis by H&E staining.
Nasal and nasopharyngeal paraganglioma
Authors: Kuhn Joseph A. , Aronoff Billie L. 
Published: February 2007

AbstractParagangliomas of the nasal cavity and nasopharynx should be classified according to the presumed origin from the nasal, jugulotympanic, vagal, or ciliary paraganglion because of the substantial differences in clinical behavior and operative management. This paper presents the ninth published case of a primary nasal paraganglioma and reviews the previously reported cases. Primary nasal paragangliomas are generally localized, although the potential for local invasion is well documented. Malignancy or functional activity has not been described. Complete excision is curative. Jugulotympanic, vagal, and ciliary paragangliomas with extension into the nasopharynx or nasal cavity are typically more advanced at the time of diagnosis and require complete evaluation by computed tomography and arteriography to determine the tumor extent. The operative approach is dependant on the extent of tumor invasion. Irradiation and tumor embolization have been useful for unresectable or partially excised tumors.
Individual treatment for malignant melanoma
Authors: Polk Hiram C. 
Published: February 2007

AbstractMuch has been learned in the recent decade about the predictable biologic behavior of cutaneous malignant melanoma. Indeed, such knowledge permits highly individualized treatment based on simple demographic data on the patient, location of the lesion, and its thickness according to the Breslow scale. The thoughtful surgeon may individualize his treatment according to the likely biologic behavior of the tumor, minimizing treatment morbidity while maintaining optimum results from primary and secondary surgical treatment.
Advanced basal cell carcinoma and successful treatment with chemotherapy
Authors: Chawla Sant P. , Benjamin Robert S. , Ayala Alberto G. , Carrasco C. Humberto , Hong Waunc Kl , Martin Richard G. 
Published: February 2007

AbstractThe patient presented in this report has a large basal cell carcinoma on the wrist and thigh. The lesion on the wrist was nonresectable without amputation. The patient showed an impressive response to chemotherapy with systemic cyclophosphamide, adriamycin, and intra‐arterial cisplatin. The tumor could be excised by a simple excision on both sites and showed no residual tumor on the hand and only a microscopic focus on the thigh. The patient continues to be free of disease 3 years after the initiation of the therapy.
Leukocyte alkaline phosphatase and carcinoembryonic antigen in breast cancer patients: Clinical correlation with the markers
Authors: Walach Natalio , Guterman Amiram , Zaidman Jacob L. , Kaufman Suzana , Scharf Sally 
Published: February 2007

AbstractLeukocyte alkaline phosphatase (LAP) scores in peripheral blood and plasma carcinoembryonic antigen (CEA) levels were determined in 208 breast cancer patients with nonmetastatic disease. Patients were followed until clinical manifestations of metastases appeared. Then the LAP score and CEA level were analyzed in relation to the clinical appearance of metastases.Of the 208 patients studied, 58 developed metastases during the follow‐up period. The LAP scores and CEA levels of this group of patients were compared to a control group of 60 breast cancer patients who did not develop metastases. Of the two markers, LAP score seems to be considerably more useful in detecting metastatic disease.
Evolving role of surgical treatment in limited‐disease small cell lung carcinoma
Authors: Sridhar Kasi S. , Hussein Atif M. , Thurer Richard J. 
Published: February 2007

AbstractThe diagnostic role of surgical procedures in small cell lung carcinoma (SCLC) is well established. The therapeutic role of surgery has changed over the years. At present, curative resection is the treatment of choice in peripheral T1‐2 NoMo SCLC, and adjuvant chemotherapy may be beneficial. Surgery is also indicated in SCLC patients diagnosed by a limited pathologic sample in whom the clinical course suggests nonsmall cell lung carcinoma (NSCLC). The resection may reveal either a mixed tumor or an alternate diagnosis and may be potentially curative. Surgery, at the time of maximal response to chemotherapy in T3NoMo SCLC, may be curative and reveal the presence of NSCLC elements. The best survival is in patients found to be tumor‐free at surgery, and the worst survival is in N2 patients.