bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of α1β1 and reduced expression of other β1 integrins and cam in lung adenocarcinoma compared with pneumocytes
Authors: Roussel Eugène , Gingras Marie‐Claude , Ro Jae Y. , Branch Cynthia , Roth Jack A. 
Published: February 2007

AbstractAlterations in expression of various cell‐adhesion molecules have been reported in a variety of malignant tissues. However, little is known about how lung adenocarcinomas differ in CAM expression from the normal lung. We analyzed the expression of integrins α1β1, intercellular adhesion molecule (ICAM)‐1, neural cell adhesion molecule (NCAM), and lymphocyte function antigen (LFA)‐3, CD44, and the two carbohydrate antigens, Lewisx (Lex) and sialosyl‐Le‐Lex of lung adenocarcinoma cells, and compared them with autologous pneumocytes. CAM expression was studied by an immunohistochemical method using monoclonal antibodies, and computerized image analysis was used to quantify the immunoperoxidase‐staining intensity. The normal lung alveolar cells strongly expressed the integrins α1β1 and α3β1, and fairly expressed α2β1, α4β1, α5β1, and α6β1. ICAM‐1, LFA‐3, and CD44 were strongly expressed, whereas NCAM, the Lex and sialosyl‐Le‐Lex antigens, were expressed weakly. In contrast, we did not detect expression of the α1β1 integrin on any autologous lung adenocarcinoma cells, and they showed on average a 50% reduction in labeling relative intensity units for the integrin common chain marker β1, the specific integrins α3β1, α5β1, and α6β1, and ICAM‐1, and LFA‐3. Examination of the adjacent small blood vessel endothelium in malignant lung tissues did not reveal any major alterations in CAM expression, the small vessel endothelium of the normal and malignant lung tissues appeared with a similar CAM profile. These results suggest that lung adenocarcinoma cells have a lack α1β1 expression and significant reduction in some other integrin β1 and CAM expression in comparison with their autologous pneumocytes. This aberration in CAM expression by the lung adenocarcinoma cells may be involved in their loss of proliferation control and may interfere with leukocyte adhesion to tumor cells, enabling the tumor to escape immunodestruction. © 1994 Wiley‐Liss, Inc.
Treatment of locally recurrent soft tissue sarcomas of the retroperitoneum: Report of 30 cases
Authors: Wang Ya‐Nong , Zhu Wei‐Qi , Shen Zhen‐Zhou , Li Shu , Liu Shou‐Ye 
Published: February 2007

AbstractTo assess the results in treating locally recurrent soft tissue sarcomas of the retroperitoneum, we reviewed the clinical, therapeutic, and pathologic characteristics of 30 patients who underwent surgical exploration. Complete resection was achieved in 18 patients (60%), 6 with en bloc resection of adjacent organs involved by the tumors. Following the first operation for recurrent lesions, the median survival was 33 months for those undergoing complete resection and 14 months for those undergoing partial resection or biopsy (P = 0.04). Patients with a disease‐free interval (DFI) of > 24 months were associated with better prognosis than those with DFI of ⩽ 24 months (median survival: 40 months vs. 17 months, P = 0.03). Patients with tumor size of ⩽ 20 cm had longer survival than those with tumor size of > 20 cm (median survival: 39 months vs. 23 months, P = 0.04). Among 14 patients who received adjuvant radiation therapy, four patients whose tumors had been considered unresectable at first exploration for recurrence underwent complete resection after preoperative radiation therapy. An aggressive surgery aimed at complete resection in treating recurrent retroperitoneal sarcomas is strongly recommended. We suggest that in large tumors preoperative radiation therapy should be used to reduce the tumor volume and therefore a higher rate of complete resection may be achieved. © 1994 Wiley‐Liss, Inc.
New trends in surgery for gastric cancer in Japan
Authors: Sawai Kiyoshi , Takahashi Toshio , Suzuki Hiroyoshi 
Published: February 2007

AbstractAlthough standard radical gastrectomy for gastric cancer, including lymph node dissection of compartments I and II, has been commonly utilized in Japan, new trends in gastric cancer surgery recently have been developed. In the treatment of early gastric cancer, endoscopic and limited surgeries have become more prevalent, whereas for advanced gastric cancer, super extended radical gastrectomy (SERG) and aggressive adjuvant therapy have been applied. Limited surgery includes wedge resection of the stomach, pylorus‐preserving gastrectomy, vagus‐preserving gastrectomy, and proximal gastrectomy. The purpose of these more limited techniques is usually to improve quality of life after surgery. Since Takahashi's lymph node staining method using fine activated carbon particles (CH40) made possible systematic para‐aortic lymph node dissection, SERG has increased in popularity. The survival rate of patients with para‐aortic lymph node metastases who underwent SERG was higher than that of patients who underwent extended radical gastrectomy. © 1994 Wiley‐Liss, Inc.
A valid new approach in treating solitary new lesions after resection of hepatocellular carcinoma
Authors: Eguchi Akira , Furuta Toshiya , Haraguchi Masaru , Sugimachi Kelzo 
Published: February 2007

AbstractRecent studies have suggested that the appearance of solitary new lesions after a curative resection of hepatocellular carcinoma (HCC) may be closely related to the metachronous multicentric development of HCC. It is therefore extremely important to investigate the histological characteristics of solitary new nodular lesions confirmed to be HCC by an ultrasound(US)‐guided needle biopsy.Thirty‐five patients with small HCC, ⩽ 3 cm in diameter, who underwent a curative hepatic resection between 1987 and 1992, were observed for possible recurrence over a period of ⩾1 year.Solitary new lesions confirmed to be HCC were noted in 7 (20.0%) out of 35 cases 10‐65 months after operation. All solitary new lesions underwent US‐guided needle biopsy, and a histological examination of the biopsy specimen was performed. All seven solitary new lesions were then classified into the following two groups according to the histologic differentiation of biopsy specimens and were found to consist of five well‐differentiated HCCs (71.4%) and two moderately differentiated HCCs (28.6%). Three of the five well‐differentiated HCCs were accompanied by varying degrees of fatty changes.These morphologic observations suggest that approximately 70% of the solitary new lesions confirmed to be HCC after a curative resection of small HCC may thus be related to the metachronous multicentric origin of HCC. However, it is difficult to estimate the exact incidence of such cases. As a result, curative treatment may sometimes be feasible, even when treating solitary new lesions after resection of HCC. Therefore, we can better evaluate such solitary new nodular lesions after a resection of HCC by means of a histologic evaluation using US‐guided needle biopsy. © 1994 Wiley‐Liss, Inc.
Streptokinase inhibits pulmonary tumor seeding in an animal experimental model
Authors: McCulloch Peter , Choy Alfred , Purushotham Anand D. , Brown Douglas C. , George William D. 
Published: February 2007

AbstractOne aspect of the metastatic process involves entrapment of tumor cells within the microcirculation of organs in a “fibrin‐platelet mesh.” We postulate that destruction of this mesh by fibrinolysis might discourage tumor seeding, thereby inhibiting metastasis. To study this hypothesis, the effect of intravenous streptokinase on pulmonary tumor seeding was examined in a rodent model. In vitro experiments demonstrated that streptokinase had no cytotoxic or cytostatic effect on the Mtln3 cell line. Pharmacokinetic studies showed that at 30,000 U/kg, streptokinase caused systemic fibrinolysis in the Fischer rat, as demonstrated by the thrombin time and fibrin plate lysis assay. Streptokinase administered at this dose, 30 min after tumor cell injection, caused a significant decrease in pulmonary tumor seeding (median 23.0 in the streptokinase‐treated group vs, 67.5 in untreated controls, P < 0.0001, Mann‐Whitney U‐test). Analysis of fibrin degradation products in the streptokinase‐treated group suggested that this effect might be secondary to fibrinolysis. The implications of these findings are discussed. © 1994 Wiley‐Liss, inc.
Adequacy of lymphadenectomy in laparoscopic‐assisted colectomy for colorectal cancer: A preliminary report
Authors: Gray Douglas , Schlinkert Richard , Lee Henry , Beart Robert W. 
Published: February 2007

AbstractThe hypothesis that the length of bowel and amount of mesentery resected with laparoscopically assisted colectomy are comparable to traditional open techniques was tested by means of a chart review of prospectively collected data of 22 laparoscopically assisted colectomies, 35 open colectomies performed by the same surgeon, and 39 other open colectomies performed at the same institution by other community surgeons. The average length of bowel resected in the laparoscopically assisted group was 21.7 cm, for the traditionally resected group, 31.4 cm, and for the other group, 26.7 cm. No statistically significant differences existed between the three evaluable groups. Although there was a trend toward greater length of bowel resected with the open technique, there was no statistically significant difference in the length of bowel resected or the number of lymph nodes identified in this study. Follow‐up at a mean of 24 months after resections shows no abdominal wall recurrences or any unusual patterns of recurrence.It is concluded that laparoscopically assisted colectomy can be performed in select groups to obtain adequate surgical resection for colorectal carcinoma. Further studies to generate larger numbers of patients with longer follow‐up to determine the adequacy of resection as well as the comparability of cure rate will be necessary to confirm the findings of this preliminary study. © 1994 Wiley‐Liss, Inc.
State of mutational alterations of p53 and retinoblastoma susceptibility genes in papillomavirus‐negative small cell cervical carcinomas
Authors: Pao Chia C. , Kao Shu‐Min , Chen Jui Hsiung , Tang Gu‐Chin , Chang Pi Yueh , Tan Ting Ting 
Published: February 2007

AbstractGenetic aberrations were examined to assess the possible roles that p53 and retinoblastoma susceptibility genes might have played in the development of small cell cervical carcinomas. Cervical cancer tissues from 12 patients with small cell cervical carcinoma that were free of human papillomavirus were analyzed. The presence of mutational alterations were examined by polymerase chain reaction‐single‐strand conformation polymorphism and by direct DNA sequencing. None of 12 small cell cervical carcinomas were found to contain mutations in regions of p53 and retinoblastoma susceptibility genes that were functionally important and where most mutations in human tumors have been found. Furthermore, there was no evidence indicative of loss of heterozygosity of chromosome region 17p13 (in which p53 is located) in these tumors. These data seem to suggest that whereas mutant type of p53 and retinoblastoma susceptibility genes may exhibit “oncogenic” function in many human tumors, mutational inactivation of these genes may not be an important feature in the carcinogenic development of human papillomavirus‐negative small cell cervical carcinomas. © 1994 Wiley‐Liss, Inc.
Histological necrosis in soft tissue sarcoma following preoperative irradiation
Authors: Kandel Lisa Hew, Rita , Davis Aileen , Bell Robert , O'Sullivan Brian , Catton Charles 
Published: February 2007

AbstractForty‐eight patients with soft tissue sarcomas that presented adverse features for treatment by limb salvage surgery and postoperative irradiation were treated by preoperative irradiation and surgery using a consistent protocol. Following resection, the extent of histological necrosis in the specimen was scored according to the criteria of Willet et al. [11]. Of the 48 cases, 16 (34%) demonstrated Grade 1 response (<50% necrosis), 15 (31%) Grade 2 (50‐80% necrosis), and 17 (35%) Grade 3 (>80% necrosis). There was a trend toward more extensive necrosis in liposarcoma tumors (53% showing Grade 3 response compared to 26% of other sarcomas). Logistic regression analysts demonstrated a significant relationship between necrosis and tumor size (P < 0.001) with larger tumors having higher grades of necrosis. Tumor grade did not seem to affect the extent of necrosis. In comparison to the previous report of necrosis in soft tissue sarcoma following irradiation [10], the current analysis revealed a smaller proportion of tumors with Grade 3 necrosis. © 1994 Wiley‐Liss, Inc.
Prolactin: Its role in advanced tongue cancer
Authors: Bhatavdekar Jyotsna M. , Patel Devendra D. , Vora Hemangini H. , Shah Neelam G. , Karelia Nilkamal H. , Ghosh Nandita , Balar Damodar B. 
Published: February 2007

AbstractSerum prolactin was measured pretherapeutically and sequentially thereafter using immunoradiometric assay method in 37 male patients with advanced tongue cancer and compared with 23 healthy, age‐matched controls. Prolactin levels were correlated with age, various clinicopathologic parameters, overall survival, and patients with response and those with progressive disease. Patients with advanced tongue cancer had higher prolactin levels than controls (P < 0.02), but intergroup variation in prolactin was not observed when considering the age, site of the lesion, disease stage, histologic grade, and keratin. Of the patients, 30% had hyperprolactinemia (prolactin >15.0 ng/ml). To assess the prognostic significance of pretherapeutic prolactin level, the patients were divided according to the cutoff level of prolactin (15.0 ng/ml). Hyperprolactinemic patients had more unfavourable prognosis than patients with prolactin <15.0 ng/ml (X2=2.91, df=1, P < 0.0037). In monitoring disease course, patients who responded to treatments had decreased prolactin levels at the end of 18 months as compared to their pretherapeutic levels (P < 0.01). In patients who subsequently developed progressive disease within 18 months, prolactin levels reduced initially at response, whereas with disease progression, prolactin levels increased significantly (P < 0.05). The positive and negative predictive value of prolactin was 100%. Immunohistochemical localization confirmed the ectopic production of prolactin by tongue tumors. In conclusion, our data indicate that hyperprolactinemia may be an independent predictor of short‐term prognosis; circulating prolactin may be used as a marker for monitoring disease course in patients with advanced tongue cancer, and prolactin is produced ectopically by tongue tumors. © 1994 Wiley‐Liss, inc.
Complications of transhiatal esophagectomy
Authors: Katariya Kushagra , Harvey James C. , Pina Edward , Beattie Edward J. 
Published: February 2007

AbstractA total of 23 papers published between 1981 and 1992, reporting a total of 1,353 patients, were reviewed for intraoperative and postoperative complications of transhiatal esophagectomy. Intraoperative complications included massive bleeding, tracheal injuries, cardiac arrhythmias, and incidental splenectomies. Even though the chest was not opened, the commonest postoperative complications were pulmonary. Leakage from the cervical anastomosis was seen in as many as 15% of all patients, but almost all resolved spontaneously. Postoperative benign strictures were seen in almost as many patients. Hoarseness due to recurrent laryngeal nerve injury, symptomatic gastro‐esophageal reflux, chylothorax, Horner's syndrome, subphrenic abscess, hiatal hernia, and biliary cutaneous fistula were some of the other postoperative complications. An overview of these complications is presented, along with suggested methods of avoiding them and their treatment. The overall mortality for the 1,353 patients was 7.17%. © 1994 Wiley‐Liss, Inc.
In vivo activity of bleomycin incorporated with biodegradable poly‐d, i‐lactic acid and implanted in the mediastinum of dogs
Authors: Kumanohoso Toru , Natsugoe Shoji , Shimada Mario , Aikou Takashi , Nakamura Kazuo , Yamada Katsushi , Fukuzaki Hironobu 
Published: February 2007

AbstractThe possible usefulness of bleomycin incorporated with biodegradable poly‐d, l‐lactic acid (BLM‐PLA) for targeting chemotherapy for esophageal cancer was studied in vivo. Local levels of BLM after administration were compared with those after injection of BLM‐SOL, an aqueous solution of BLM. BLM‐PLA or BLM‐SOL was administered into the upper mediastinum under a right thoracotomy in 36 mongrel dogs. On days 10, 20, and 30 after administration, connective tissues, lymph nodes, lung, liver, kidney, and spleen were removed, and BLM activity was measured. High activity of BLM was detected for 30 days after BLM‐PLA administration in both the connective tissues and the lymph nodes, compared with BLM‐SOL administration. BLM activity was low in the other organs after BLM‐PLA administration. BLM in the blood was significantly lower after administration of BLM‐PLA than BLM‐SOL. The results indicate that BLM‐PLA may become a useful tool in targeting chemotherapy for esophageal cancer. © 1994 Wilev‐Liss, Inc.
Discrepancy between PNMT presence and relative lack of adrenaline production in extra‐adrenal pheochromocytoma
Authors: Funahashi Hiroomi , Imai Tsuneo , Tanaka Yuji , Tobinaga Jun‐Ichi , Wada Masaki , Matsuyama Takako , Tsukamura Kyosuke , Yamada Fumio , Takagi Hiroshi , Narita Tatsuhiko , Koshikawa Takashi 
Published: February 2007

AbstractAmong catecholamine synthesizing enzymes, phenylethanolamine‐N‐methyltransferase (PNMT) exists only in adrenal and extra‐adrenal pheochromoeytoma has been believed not to produce adrenaline. However, adrenaline production is clinically active in some extra‐adrenal cases. To investigate this controversy, the localization of catecholamine synthesizing enzymes was studied by immunohistochemical staining in extra‐adrenal and adrenal cases. The results showed that PNMT was expressed not only in many cases of adrenal pheochromocytoma, but also in extra‐adrenal pheochromocytoma. It is suspected that little adrenaline production in extra‐adrenal cases is attributable to a lack of a good environment for the activation of PNMT by a high concentration of glucocorticoids. © 1994 Wiley‐Liss, Inc.
Clear cell carcinoma of the liver with spontaneous regression of metastases
Authors: McDermott William V. , Khettry Urmila 
Published: February 2007

AbstractThe purpose of this report is to establish in some detail a case of spontaneous regression of metastases secondary to a clear cell hepatocellular carcinoma. A review of the hepatocellular carcinomas from this department has been previously reported, and this particular study focuses on the two lesions that have the microscopic classification referred to above. One young female patient was 23 at the time of resection of the clear cell carcinoma of the liver plus diffuse intrahepatic metastases. She has been followed carefully over the years and has been seen as recently as June 1993. At that time, studies including ultrasonic and CT scan examinations of liver were carried out, all of which were negative for any evidence of residual disease. The evidence presented in this report would seem to establish conclusively that a spontaneous regression of the metastases from a clear cell carcinoma of the liver had occurred without any medication and without any obvious alteration in diet or state of health. © 1994 Wiley‐Liss, Inc.
Flow cytometric measurement of proliferation‐associated nuclear antigen p105 and DNA content in immuno‐proliferative small intestinal disease (IPSID)
Authors: Demirer Taner , Uzunalimoglu Ozden , Anderson Tom , Koethe Susan M. , McFadden Patrick W. , Demirer Seher , Uzunalimoglu Bedri , Kucuk Omer 
Published: February 2007

AbstractImmunoproliferative small intestinal disease (IPSID), most common in Mediterranean countries, is characterized by lymphomatous infiltration of the small intestine and is usually associated with the synthesis of anomalous immunoglobulin alpha heavy chains. Flow cytometric analysis of DNA content, S phase fraction, and quantitative analysis of the proliferation‐associated nuclear antigen, P105, were performed in 23 patients with IPSID to determine if they could be used as prognostic indicators in this disease. Eighteen patients had low‐grade, two had intermediate‐grade, and three had high‐grade lymphoma. Eight patients had clinical stage IE disease, 12 had stage IIE, and three had stage IIIE disease. Eleven patients survived >5 yr (good prognosis), four survived between 2–5 yr (intermediate prognosis), and eight survived 2 yr or less (poor prognosis). The S phase fraction of patients with poor prognosis was significantly higher than those with intermediate or good prognosis (P < 0.004). Flow cytometric evaluation of S phase fraction may offer important prognostic information in patients with IPSID and could be useful in the clinical management of patients with this highly variable clinical syndrome. Further studies evaluating the value of DNA flow cytometry in larger groups of patients with IPSID are warranted. © 1995 Wiley‐Liss, Inc.
Usefulness of platelet‐derived growth factor as a prognostic factor in pulmonary adenocarcinoma
Authors: Takanami Iwao , Yamamoto Yasuki , Kodaira Susumu , Imamura Tetsuo 
Published: February 2007

AbstractPlatelet‐derived growth factor (PDGF) in the resected pulmonary adenocarcinoma tissue of 88 patients was detected immunohistochemically by the avidin‐biotin‐peroxidase technique to determine whether or not it is a prognostic parameter. The 88 patients were divided into PDGF (‐) and PDGF (+) groups according to the stainability of the factor. The PDGF (‐) group included 39 patients and the PDGF (+) group 49. The 5‐year survival rate was 53% for the PDGF (‐) group and 17% for the PDGF (+) group (P < 0.01). These findings indicate that the stainability of PDGF can be a prognostic parameter for pulmonary adenocarcinoma. © 1995 Wiley‐Liss, Inc.
Concurrent chemotherapy (5‐fluorouracil and cisplatin) and radiation therapy for inoperable squamous cell carcinoma of the esophagus potentially followed by surgery
Authors: Tsujinaka Toshimasa , Shiozaki Hitoshi , Kido Yoshihiro , Murata Atsuo , Nishijima Jun‐Ichi , Inoue Masatoshi , Iijima Shohei , Inoue Takehiro , Mori Takesada 
Published: February 2007

AbstractTwenty‐four previously untreated patients with primary inoperable squamous cell carcinoma of the esophagus showing no evidence of hematogenous metastasis were treated with concurrent chemotherapy and radiation therapy (CRT) followed by surgical resection if possible. The chemotherapy regimen consisted of 5‐fluorouracil 750 mg/m2 on days 1–4 and 21–24, and cisplatin 70 mg/m2 on days 1 and 21. Radiation therapy was administered over days 1–26 (200 cGy/day five times per week with an initial planned dose of 40 Gy). Five patients (8%) showed complete response (CR), 14 patients (58%) had partial response (PR), and 19 had good local control (CR 2, PR 17). Eleven cases (48%) underwent esophageal resection with no operative mortality. Curative resection was accomplished in eight cases (35%). Toxicities observed in CRT were leukopenia (grades 3 and 4) 38%, nausea and vomiting (grades 2 and 3) 67%, esophagitis 42%, and fever 42%. The median survival time (MST) for 11 neoadjuvant cases was 349 days (P < 0.05) compared to 212 days for palliative treatment (six cases) and 126 days for no treatment (six cases) after CRT. The MST of eight patients who received curative resection had not been reached after a 17‐month median follow‐up time. Concurrent chemotherapy with 5‐fluorouracil plus cisplatin and radiation proved to be a safe regimen yielding a satisfactory response and minimal toxicity in this particular group of patients. Extensive surgery was thus determined to be feasible after CRT and to contribute to prolonging survival. © 1995 Wiley‐Liss, Inc.