bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesoporous polydopamine Targeting CDK4/6 Inhibitor toward Brilliant Synergistic Immunotherapy of Breast Cancer
Authors: Zhou Conglei , Zhao Shuang , Zhang Yongbo , Cheng Jianjun , Shi Jiahua , Du Guanhua 
Published: February 2024

AbstractImmunotherapy utilizing anti‐PD‐L1 blockade has achieved dramatic success in clinical breast cancer management but is often hampered by the limited immune response. Increasing evidence shows that immunogenic cell death (ICD) recently arises as a promising strategy for enlarging tumor immunogenicity and eliciting systemic anti‐tumor immunity effectively. However, developing simple but versatile, highly efficient but low‐toxic, biosafe, and clinically available transformed ICD inducers remains a huge demand and is highly desirable. Herein, a multifunctional ICD inducer is purposefully developed A6‐MPDA@PAL by integrating photothermal therapy (PTT) nanoplatforms mesoporous polydopamine (MPDA), CDK4/6 inhibitor palbociclib (PAL), and CD44‐specific targeting A6 peptide in a simple way for augmenting the immune antitumor efficacy of anti‐PD‐L1 therapy. Remarkably, the light‐inducible nanoplatforms exhibit multiple favorable therapeutic features ensuring a superior and biosafe PTT/chemotherapy efficacy. Together with stronger accumulative ICD induction, single administration of A6‐MPDA@PAL can trigger robust systemic antitumor immunity and abscopal effect with the assistance of anti‐PD‐L1 blockade by fascinating the intratumoral infiltration of T lymphocytes and reversing the immunosuppressive tumor microenvironment simultaneously, therapy achieving brilliant synergistic immunotherapy with effective tumor ablation. This study presents a simple and smart ICD inducer opening up attractive clinical possibilities for reinforcing the anti‐PD‐L1 therapy against breast cancer.
Interface‐Engineered NiFe/Ni‐S Nanoparticles for Reliable Alkaline Oxygen Production at Industrial Current: A Sulfur Source Confinement Strategy
Authors: Chen Bin , Liu Tao , Zhang Junfeng , Zhao Shuo , Yue Runfei , Wang Sipu , Wang Lianqin , Chen Zhihao , Feng Yingjie , Huang Jun , Yin Yan , Guiver Michael D. 
Published: February 2024

AbstractUsing powder‐based ink appears to be the most suitable candidate for commercializing the membrane electrode assembly (MEA), while research on the powder‐based NPM catalyst for anion exchange membrane water electrolyzer (AEMWE) is currently insufficient, especially at high current density. Herein, a sulfur source (NiFe Layered double hydroxide adsorbed ) confinement strategy is developed to integrate Ni3S2 onto the surface of amorphous/crystalline NiFe alloy nanoparticles (denoted NiFe/Ni‐S), achieving advanced control over the sulfidation process for the formation of metal sulfides. The constructed interface under the sulfur source confinement strategy generates abundant active sites that increase electron transport at the electrode‐electrolyte interface and improve ability over an extended period at a high current density. Consequently, the constructed NiFe/Ni‐S delivers an ultra‐low overpotential of 239 mV at 10 mA cm−2 and 0.66 mA under an overpotential of 300 mV. The AEMWE with NiFe/Ni‐S anode exhibits a cell voltage of 1.664 V @ 0.5 A cm−2 and a 400 h stability at 1.0 A cm−2.
Ionic Covalent Organic Framework as a Dual Functional Sensor for Temperature and Humidity
Authors: Das Gobinda , Ibrahim Fayrouz Abou , Khalil Zahraa Abou , Bazin Philippe , Chandra Falguni , AbdulHalim Rasha G. , Prakasam Thirumurugan , Das Akshaya Kumar , Sharma Sudhir Kumar , Varghese Sabu , Kirmizialtin Serdal , Jagannathan Ramesh , Saleh Na'il , Benyettou Farah , Roz Mohamad El , Addicoat Matthew , Olson Mark A. , Rao D. S. Shankar , Prasad S. Krishna , Trabolsi Ali 
Published: February 2024

AbstractVisual sensing of humidity and temperature by solids plays an important role in the everyday life and in industrial processes. Due to their hydrophobic nature, most covalent organic framework (COF) sensors often exhibit poor optical response when exposed to moisture. To overcome this challenge, the optical response is set out to improve, to moisture by incorporating H‐bonding ionic functionalities into the COF network. A highly sensitive COF, consisting of guanidinium and diformylpyridine linkers (TG‐DFP), capable of detecting changes in temperature and moisture content is fabricated. The hydrophilic nature of the framework enables enhanced water uptake, allowing the trapped water molecules to form a large number of hydrogen bonds. Despite the presence of non‐emissive building blocks, the H‐bonds restrict internal bond rotation within the COF, leading to reversible fluorescence and solid‐state optical hydrochromism in response to relative humidity and temperature.
Synergistic Effects of Dual‐Doping with Ni and Ru in Monolayer VS2 Nanosheet: Unleashing Enhanced Performance for Acidic HER through Defects and Strain
Authors: Wang Ruonan , Chen Qian , Liu Xinzheng , Hu Yubin , Cao Lixin , Dong Bohua 
Published: February 2024

AbstractAmidst the escalating quest for clean energy, the hydrogen evolution reaction (HER) in acidic conditions has taken center stage, catalyzing the search for advanced electrocatalysts. The efficacy of these materials is predominantly dictated by the active site density on their surfaces. The propensity is leveraged for monolayer architectures to introduce defects, enhancing surface area, and increasing active sites. Doping enhances defects and fine‐tunes catalyst activity. In this vein, defect‐enriched monolayer nanosheets doped with nickel and a trace amount of ruthenium in VS2 (SL‐Ni‐Ru‐VS2) are engineered and characterized. Evaluation in 0.5 m H2SO4 solution unveils that the catalyst achieves overpotentials as low as 20 and 41 mV at current densities of ‐10 and ‐100 mA cm⁻2. Impressively, the catalyst maintains a mass activity of 13.08 A mg⁻¹Ru, even with minimal Ru incorporation, indicating exceptional catalytic efficiency. This monolayer catalyst sustains its high activity at lower overpotentials, demonstrating its practical applicability. The comprehensive analysis, which combines experimental data and computational simulations, indicates that the co‐doping of Ni and Ru enhances the electrocatalytic properties of VS2. This research offers a strategic framework for crafting cutting‐edge electrocatalysts specifically designed for enhanced performance in the HER.
Carbon Dots: A Bright Future as Anticounterfeiting Encoding Agents
Authors: Simões Raul , Rodrigues Joana , Neto Victor , Monteiro Teresa , Gonçalves Gil 
Published: February 2024

AbstractCounterfeit products and data vulnerability present significant challenges in contemporary society. Hence, various methods and technologies are explored for anticounterfeiting encoding, with luminescent tracers, particularly luminescent carbon dots (CDs), emerging as a notable solution. CDs offer promising contributions to product security, environmental sustainability, and the circular economy. This critical review aims to highlight the luminescence responsiveness of CDs to physical and chemical stimuli, achieved through nanoengineering their chemical structure. The discussion will delve into the various tunable luminescence mechanisms and decay times of CDs, investigating preferential excitations such as up‐conversion, delayed fluorescence, fluorescence, room temperature phosphorescence, persistent luminescence, energy and charge transfer, as well as photo‐chemical interactions. These insights are crucial for advancing anticounterfeiting solutions. Following this exploration, a systematic review will focus on the research of luminescent CDs' smart encoding applications, encompassing anticounterfeiting, product tracing, quality certification, and information encryption. Finally, the review will address key challenges in implementing CDs‐based technology, providing specific insights into strategies aimed at maximizing their stability and efficacy in anticounterfeiting encoding applications.
Non‐Covalent Interaction Enhancement on Active/Interfacial Layers via Two‐Dimensional Vermiculite Doping for Efficient Organic Solar Cells
Authors: Ding Xu , Ding Yu‐Feng , Huang Chenhui , Li Yuehao , Zhang Meng , Zhu Chunguang , Li Zhenye 
Published: February 2024

AbstractInterface modification plays an important role in improving the power conversion efficiency (PCE) of organic solar cells (OSCs). However, the low non‐covalent interaction between the cathode interface layer (CIL) and nonfullerene acceptor (NFA) directly affects the charge collection of OSCs. Here, the non‐covalent interaction between the CIL and NFA is enhanced by introducing the 2D vermiculite (VML) in the poly(9,9‐bis(3′‐(N,N‐dimethyl)‐Nethylammonium‐propyl‐2,7‐fluorene)‐alt‐2,7‐(9,9‐dioctylfluorene)) dibromide (PFN‐Br) interface layer to form an efficient electron transport channel. As a result, the electron extraction efficiency from the active layer to the CIL is increased, and the PCE of OSCs based on PBDB‐T:ITIC is boosted from 10.87% to 12.89%. In addition, the strategy of CIL doping VML is proven to be universal in different CIL materials, for which the PCE is boosted from 10.21% to 11.57% for OSCs based on PDINN and from 9.82% to 11.27% for OSCs based on PNDIT‐F3N. The results provide a viable option for designing efficient CIL for high‐performance non‐fullerene OSCs, which may promote the commercialization of OSCs.
A Novel Non‐Fullerene D‐A Interface with Two Asymmetrical Electron Acceptors Facilitates Charge and Energy Transfer for Effective Carbon Dioxide Reduction
Authors: Zhang Shiming , Hou Yanping , Zhang Libin , Zhu Hongxiang , Xiong Jianhua , Wang Shuangfei , Liu Tao 
Published: February 2024

AbstractConverting carbon dioxide (CO2) into high‐value chemicals using solar energy remains a formidable challenge. In this study, the CSC@PM6:IDT6CN‐M:IDT8CN‐M non‐fullerene small‐molecule organic semiconductor is designed with highly efficient electron donor‐acceptor (D‐A) interface for photocatalytic reduction of CO2. Atomic Force Microscope and Transmission Electron Microscope images confirmed the formation of an interpenetrating fibrillar network after combination of donor and acceptor. The CO yield from the CSC@PM6:IDT6CN‐M:IDT8CN‐M reached 1346 µmol g−1 h−1, surpassing those of numerous reported inorganic photocatalysts. The D‐A structure effectively facilitated charge separation to enable electrons transfer from the PM6 to IDT6CN‐M:IDT8CN‐M. Meanwhile, attributing to the dipole moments of the strong intermolecular interactions between IDT6CN‐M and IDT8CN‐M, the intermolecular forces are enhanced, and laminar stacking and π‐π stacking are strengthened, thereby reinforcing energy transfer between acceptor molecules and significantly enhanced charge separation. Moreover, the strong internal electric field in the D‐A interface enhanced the excited state lifetime of PM6:IDT6CN‐M:IDT8CN‐M. In situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) analysis demonstrated that carboxylate (COOH*) is the predominant intermediate during CO2 reduction, and possible pathways of CO2 reduction to CO are deduced. This study presents a novel approach for designing materials with D‐A interface to achieve high photocatalytic activity.
Revealing the Dynamic Lithiation Process of Copper Disulfide by in Situ TEM
Authors: Hu Yubing , Hu Sibo , Ren Qingye , Qiu Yuxin , Zhang Lifeng , Luo Langli 
Published: February 2024

AbstractTransition metal oxides, fluorides, and sulfides are extensively studied as candidate electrode materials for lithium‐ion batteries driven by the urgency of developing next‐generation higher energy density lithium batteries. These conversion‐type electrode materials often require nanosized active materials to enable a “smooth” lithiation and de‐lithiation process during charge/discharge cycles, determined by their size, structure, and phase. Herein, the structural and chemical changes of Copper Disulfide (CuS2) hollow nanoparticles during the lithiation process through an in situ transmission electron microscopy (TEM) method are investigated. The study finds the hollow structure of CuS2 facilitates the quick formation of fluidic Li2S “drops,” accompanied by a de‐sulfurization to the Cu7S4 phase. Meanwhile, the metallic Cu phase emerges as fine nanoparticles and grows into nano‐strips, which are embedded in the Li2S/Cu7S4 matrix. These complex nanostructured phases and their spatial distribution can lead to a low de‐lithiation barrier, enabling fast reaction kinetics.
Unlatching the Additional Zinc Storage Ability of Vanadium Nitride Nanocrystallites
Authors: Yao Xincheng , Khanam Zeba , Li Chenglin , Koroma Malcolm , Ouyang Ting , Hu Yu‐wen , Shen Ke , Balogun M.‐Sadeeq 
Published: February 2024

AbstractVanadium‐based materials, due to their diverse valence states and open‐framework lattice, are promising cathodes for aqueous zinc ion batteries (AZIBs), but encounters the major challenges of in situ electrochemical activation process, potent polarity of the aqueous electrolyte and periodic expansion/contraction for efficient Zn2+ storage. Herein, architecting vanadium nitride (VN) nanosheets over titanium‐based hollow nanoarrays skeletal host (denoted VNTONC) can simultaneously modulate address those challenges by creating multiple interfaces and maintaining the (1 1 1) phase of VN, which optimizes the Zn2+ storage and the stability of VN. Benefiting from the modulated crystalline thermodynamics during the electrochemical activation of VN, two outcomes are achieved; I) the cathode transforms into a nanocrystalline structure with increased active sites and higher conductivity and; II) a significant portion of the (1 1 1) crystal facets is retained in the process leading to the additional Zn2+ storage capacity. As a result, the as‐prepared VNTONC electrode demonstrates remarkable discharge capacities of 802.5 and 331.8 mAh g−1 @ 0.5 and 6.0 A g−1, respectively, due to the enhanced kinetics as validated by theoretical calculations. The assembled VNTONC||Zn flexible ZIB demonstrates excellent Zn storage properties up to 405.6 mAh g−1, and remarkable robustness against extreme operating conditions.
An assessment of heterogenous ensemble classifiers for analyzing change‐proneness in open‐source software systems
Authors: Khanna Megha , Bansal Ankita 
Published: February 2024

AbstractSoftware managers constantly look out for methods that ensure cost effective development of good quality software products. An important means of accomplishing this is by allocating more resources to weak classes of a software product, which are prone to changes. Therefore, correct prediction of these change‐prone classes is critical. Though various researchers have investigated the performance of several algorithms for identifying them, the search for an optimum classifier still persists. To this end, this study critically investigates the use of six Heterogenous Ensemble Classifiers (HEC) for Software Change Prediction (SCP) by empirically validating datasets obtained from 12 open‐source software systems. The results of the study are statistically assessed using three robust performance indicators (AUC, F‐measure and Mathew Correlation Coefficient) in two different validation scenarios (within project and cross‐project). They indicate the superiority of Average Probability Voting Ensemble, a heterogenous classifier for determining change‐proneness in the investigated systems. The average AUC values of software change prediction models developed using this ensemble classifier exhibited an improvement of 3%‐9% and 3%‐11% respectively when compared with its base learners and homogeneous counter parts. Similar observations were inferred using other investigated performance measures. Furthermore, the evidence obtained from the results suggests that the change in number of base learners or type of meta‐learner does not exhibit significant change in the performance of corresponding heterogenous ensemble classifiers.
Numerical analysis on flat slabs with openings and SHEAR reinforcement
Authors: Costa Sara R. , Pereira Tainá F. , Ruas Simone R. C. , Liberati Elyson A. P. , Marques Marília G. 
Published: February 2024

AbstractThe present study aims to parameterize the numerical models of flat slabs based on five experimental prototypes developed previously. The analyzed slabs had dimensions of 1800 mm × 1800 mm and a thickness of 130 mm. Two slabs did not have openings, and three slabs had stud‐type shear reinforcement. Subsequently, five new slab models were selected with position variations and several openings, with a fixed diameter of 75 mm and without shear reinforcement. After calibration of the models, the following results were obtained: the numerical rupture load approached at least 90% of the experimental rupture load, and the rupture modes and cracking patterns were similar to those observed in the experimental models. When it is impossible to move the column openings vertically, it is more beneficial to position them at the corners of the column rather than close to the same face of the column. Thus, it was possible to numerically analyze the effects of the position and number of openings in flat slabs.
Seismic performance of a frame‐supported shear wall over‐track building through shaking table test
Authors: Zhou Ying , Chen Qidong , Wu Hao , Wen Hongchang , Nong Xingzhong , Wu Yongsheng , Xiao Peng 
Published: February 2024

SummaryThis research deals with a frame‐supported shear wall for urban over‐track building of vehicle depot in Chisha, Guangzhou, China, which is characterized by its remarkable height of 160.8 m. Technical issues are commonly encountered in these kinds of buildings due to discontinuous vertical structural rigidity, large podium, and structural transition. These challenges significantly impact the engineering process, especially when the rigidity difference between transfer story exceeding the threefold, as well as the building height exceeds limit as in code. In this paper, a shaking table test was developed based on a 1:10 scaled model of the structure. Using similarity theory, the dynamic similarity relationship was established for the design of the model. Subsequently, the experimental model was constructed with the configuration of critical parameters such as mass design, sensor placement, and seismic test conditions. This was followed by in‐depth analysis, recording component failures and investigating key aspects such as dynamic characteristics, that is, acceleration and displacement responses and shear force distribution under different earthquake intensities. A theoretical seismic response of the prototype structure was derived from the test results. The shaking table tests confirmed that the structure met the stringent seismic design requirements as prescribed in the Chinese standards, with no damage under minor earthquakes, repairability under moderate earthquakes, and collapse prevention under rare earthquakes. The results of the study provide valuable insights along with improvement measures for the design and development of similar urban over‐track buildings, potentially contributing to more efficient land use in urban China.
Modal identification with uncertainty quantification of large‐scale civil structures via a hybrid operation modal analysis framework
Authors: Sun Mengmeng , Li Qiusheng 
Published: February 2024

SummaryIn operational modal analysis (OMA), only structural responses are typically available. In this context, bias and variance (uncertainty) errors may exist in modal estimates (especially damping estimates), resulting in inaccurate determination of the modal properties of large‐scale structures under harsh excitations. To this end, a hybrid OMA framework based on the modal decoupling, the natural excitation technique, the random decrement technique (RDT), and improved eigensystem realization algorithm (ERA) with the automated stabilization diagram is presented to perform high‐accuracy modal estimates with uncertainty quantification for large‐scale structures under normal and severe ambient excitations. The accuracy and effectiveness of the hybrid framework for identifying the modal parameters are validated by numerical simulation study of a framework structural model. Furthermore, the hybrid framework is applied to analyze recorded acceleration responses of a supertall building with 600‐m height under normal excitations and typhoon condition to verify its applicability in field measurements. The numerical simulation and field measurement studies demonstrate that the hybrid framework can not only perform precise modal estimations with uncertainty quantification through a single ambient vibration measurement but also effectively reveal the variations of modal properties of supertall structures under harsh excitations from multiple perspectives. This paper aims to enhance the reliability and accuracy of modal estimation for engineering structures and further provide insight into the variations of dynamic properties of large‐scale civil structures under severe excitations.
The risk of developing splanchnic vein thrombosis in acute pancreatitis increases 3 days after symptom onset: A systematic review and meta‐analysis
Authors: Borbély Ruben Zsolt , Szalai Eszter Ágnes , Philip Bryan Mangalath , Dobszai Dalma , Teutsch Brigitta , Zolcsák Ádám , Veres Dániel Sándor , Erőss Bálint , Gellért Bálint , Hegyi Péter Jenő , Hegyi Péter , Faluhelyi Nándor 
Published: February 2024

AbstractBackgroundSplanchnic vein thrombosis is a complication of acute pancreatitis (AP) and is likely often underdiagnosed.ObjectivesWe aimed to understand the time course and risk factors of splanchnic vein thrombosis in the early phase of AP.MethodsA systematic search was conducted using the PRISMA guidelines (PROSPERO registration CRD42022367578). Inclusion criteria were appropriate imaging techniques in adult AP patients, studies that reported splanchnic vein thrombosis data from the early phase, and reliable information on the timing of imaging in relation to the onset of pancreatitis symptoms or hospital admission. The proportion of patients with thrombosis with 95% confidence intervals (CI) was calculated using random‐effects meta‐analyses, and multiple subgroup analyses were performed.ResultsData from 1951 patients from 14 studies were analyzed. The proportion of patients with splanchnic vein thrombosis within 12 days after symptom onset was 0.13 (CI 0.07–0.23). The occurrence was lowest at 0.06 (CI 0.03–0.1) between 0 and 3 days after symptom onset, and increased fourfold to 0.23 (CI 0.16–0.31) between 3 and 11 days. On hospital admission, the proportion of patients affected was 0.12 (CI 0.02–0.49); it was 0.17 (CI 0.03–0.58) 1–5 days after admission. The prevalence in mild, moderate, and severe AP was 0.15 (CI 0.05–0.36), 0.26 (CI 0.15–0.43), and 0.27 (CI 0.17–0.4), respectively. Alcoholic etiology (0.31, CI 0.13–0.58) and pancreatic necrosis (0.55, CI 0.29–0.78, necrosis above 30%) correlated with increased SVT prevalence.ConclusionThe risk of developing splanchnic vein thrombosis is significant in the early stages of AP and may affect up to a quarter of patients. Alcoholic etiology, pancreatic necrosis, and severity may increase the prevalence of splanchnic vein thrombosis.
Strain/pressure sensors utilizing advanced nanomaterials
Authors: Nhiem Ly Tan , Oanh Doan Thi Yen , Hieu Nguyen Huu 
Published: February 2024

AbstractIn this study, the fabrication techniques employed for strain/pressure sensors are covered, highlighting advancements in materials and manufacturing processes. It discusses the use of nanomaterials, such as nanoparticles, nanowires, and graphene to enhance the sensitivity and durability of strain/pressure sensors. Various fabrication methods, including printing, thin‐film deposition, and microelectromechanical systems technologies, are discussed, emphasizing their superiority for strain/pressure sensing applications.