bluuebunny/crossref_metadata_2025_split huggingface dataset:
Granulocyte‐Macrophage colony stimulating factor (GM‐CSF) priming in the treatment of elderly patients with acute myelogenous leukemia
Authors: Frenette Paul S. , Desforges Jane F. , Schenkein David P. , Rabson Arthur , Siapack Christopher A. , Miller Kenneth B. 
Published: February 2007

AbstractStandard intensive induction therapy is tolerated poorly by elderly patients with acute myeloblastic leukemia (AML). We treated 19 elderly patients with AML, including seven with a prior myelodysplastic syndrome (MDS) with a combination of low dose cytarabine, hydroxyurea, and GM‐CSF. The percentage of blasts in S‐phase was evaluated prior to and 24 hr after starting the GM‐CSF infusion. Cell cycle analysis was performed by flow cytometry using propidium iodine staining with fluorescein isothiocyanate‐conjugated monoclonal antibody to the myeloid antigen CD 33.Seven out of nineteen (37%) achieved a complete remission (CR) and six (31%) a partial remission (PR) for an overall response rate of 68% (13/19). There were three early deaths from infectious complications or organ filure. One patient died from disseminated fungal infection after attaining a PR. The medial overall survival was 9.5 months with a range of 1 to 23+ months. The projected median survival for the patients with de novo AML is greater than 23 months. The percentage of CD 33+ cells in S‐phase increased from a mean of 11.6+/‐2.7 (SEM) pre GM‐CSF to 19.0+/‐3.7 (SEM) post GM‐CSF (P < 0.001). Patients with prior MDS demonstrated a greater increment (post‐pre) in S‐phase activity after GM‐CSF administration (P = 0.02). There was a correlation between the increase in percent of CD 33 + cells in S‐phase and the degree of cytoreduction as determined by the day 14 bone marrow biopsy (r = .78).The toxicity of the regimen was limited to the hematopoietic system. Sixteen out of nineteen patients (84%) and 12/13 (92%) of the responding patients had bone marrow aplasia on day 14. No patients experienced >grade 2 gastrointestinal toxicity. There was no neurologic or cardiac toxicity.These data suggest that the combination of hydroxyurea, GM‐CSF, and cytarabine is an effective remission‐induction regimen in elderly patients with AML. © 1995 Wiley‐Liss, Inc.
Cobalamin‐dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine
Authors: Gimsing Peter , Hippe Erik 
Published: February 2007

AbstractThe cobalamin metabolism in chronic myelogenous leukemia (CML) was evaluated in 18 newly diagnosed and untreated patients by formiminoglutamic acid (FiGlu) and methyl malonic acid excretion (MMA) tests. A deoxyuridine (dU) suppression test of bone marrow cells was compared in patients with acute myelogenous leukemia (N = 5), myelodysplastic disease (N = 3), untreated pernicious anemia (N = 16), folate deficiency (N = 7), and a hospital reference group without signs of cobalamin or folate deficiency (N = 22).All had normal MMA excretion but 3 of 15 patients had increased FiGlu excretion. In vitro thymidine uptake in bone marrow cells of CML patients were lower (mean 40 fmol/106 cells) than pernicious anemia patients (115 fmol/106 cells). Methotrexate (MTX) increased the uptake in all cases. Addition of formyl‐THF, methyltetrahydrofolate (methyl‐THF), and pteroylglutamic acid (PGA) tended to normalize the effect of MTX. In pernicious anemia methyl‐THF only decreased the uptake in combination with CN‐Cbl. dU suppression values were significantly higher (6.3%) in CML than in the reference group (4.4%), but significantly lower than in pernicious anemia (41.6%) and folate deficiency (28.5%). The dU suppression values in bone marrow cells of CML patients correlated significantly with the transferrin saturation. In buffy coat cells dU suppression values were even higher (9.3%) than in bone marrow cells of the same CML patients. Addition of folate forms and CN‐Cbl did not change the dU suppression values in CML, as it did in pernicious anemia. MTX increased dU suppression values significantly in all patients, but more in CML (64.5%) than in pernicious anemia (48.6%) and controls (49.8%). The MTX effect was to some extent neutralized by folate analogues with formyl‐THF as the most effective followed by methyl‐THF and lastly PGA. Methyl‐THF also neutralized MTX in pernicious anemia, but its effect was certainly enhanced by addition of CN‐Cbl. Thymidine uptake and dU suppression patterns were not significantly changed in CML after treatment with busulfan for 1 week or in accelerated phase. We concluded that signs of cobalamin or folate deficiency (apart from one patient) cannot be demonstrated in untreated CML. However, dU suppression was significantly increased and more so in circulating myeloid cells than in bone marrow. This indicates a deranged metabolism of deoxynucleotides which is independent of cobalamin and folates, and a difference between bone marrow cells and circulating cells. dU suppression is a valuable indicator of cobalamin deficiency. Preincubation with MTX may assist the diagnosis by demonstrating methyl‐THF‐neutralized thymidine up‐take and dU suppression in combination with CN‐Cbl in patients with pernicious anemia. However, further clinical studies are needed to tell whether the extension of the test is justified by giving additional clinical information. © 1995 Wiley‐Liss, Inc.
Sickle cell anemia and β‐gene cluster haplotypes in Cuba
Authors: Muniz A. , Corral L. , Alaez C. , Svarch E. , Espinosa E. , Carbonell N. , Di Leo R. , Felicetti L. , Nagel R. L. , Martinez G. 
Published: February 2007

AbstractWe have studied 91 patients with SS genotype, 44 children and 47 adults. Excluding the Cameroon and atypical haplotypes, the distribution in the children's sample exhibited 43% Benin, 38% Bantu, and 3% Senegal. In adults, the sample exhibited 46% Benin, 30% Bantu, and 9% Senegal (x2: 13.511, 2 df, P = 0.001). When the whole sample of 198 chromosomes (SS, SC, and S/βthal) is considered, we find that the βs chromosome is linked 51% to the Benin haplotype, 41% with the Bantu, and 8% with the Senegal. After adjusting for the different frequencies of βs in Africa, these numbers would predict the port of origin to be 16% from Atlantic West Africa, 37.3% from Central West Africa, and 46% from Bantu‐speaking Africa. This is in direct contradiction with the historical record that establishes a higher percentage from Bantu‐speaking Africa (55%) and a much lower percentage from Senegal (3.4%). The overall conclusions from these findings is that there is a loss of Bantu haplotypes in sickle cell syndromes in Cuba, particularly among adults, and that there is an excess of Senegal haplotype, also among adults. These differences might reflect the differential survival and severity of the sickle cell disease linked to these haplotypes. © 1995 Wiley‐Liss, Inc.
Autoantibody to factor VIII that has less reactivity to factor Vlll/von Willebrand Factor Complex
Authors: Amano Kagehiro , Arai Morio , Koshihara Kimihito , Suzuki Takashi , Kagawa Kazuhiko , Nishida Yasuharu , Fukutake Katsuyuki 
Published: February 2007

AbstractTo determine the difference in reactivity of factor Vlll (FVIII) inhibitor to FVlll/von Willebrand Factor (vWF) complex and FVlll free of vWF, an autoantibody to FVlll light chain was tested. A patient (1‐3) suffered from autoimmune hemolytic anemia with autoantibody to FVIII. Epitope specificity of the patient's IgG (1‐3 IgG) was shown to be the C2 domain of FVlll light chain (2170‐2332) by Western blotting using recombinant FVlll deletions expressed in Escherichia coli. The inhibitory effect on FVlll procoagulant activity (VIII :C) of 1‐3 lgG was tested against a conventional FVlll concentrate; Haemate P, a monoclonal antibody‐purified FVlll concentrate; Hemofil M, and a recombinant FVlll (rFVIII); Kogenate. 1‐3 lgG showed only 1.3 BU/mgIgG for Haemate P, in contrast to 20 BU/mglgG for both Hemofil M and Kogenate. The ratio of VIII:C/vWF:Ag in Haemate P and Hemofil M was 1/3.43 and 1/0.01, respectively, while Kogenate did not contain vWF. The inhibitory effect of the 1‐3 IgG was then compared with Kogenate and its complex with vWF. The inhibitory effect was decreased against the rFVlll by forming a complex with vWF. from 22 BU/mglgG to o.5 BU/mgIgG. Fab from the 1‐3 IgG had the same effect. In addition, vWF showed a protective effect on FVlll inactivation by the 1‐3 IgG in a dose dependent manner. Fifty‐nine percent of residual VIII:C was retained in the presence of 8 U/ml of vWF after 1 hr incubation with 1‐3 lgG. These results suggested that vWF could compete with the 1‐3 IgG for binding to FVIII. © 1995 Wiley‐Liss, Inc.
Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia
Authors: Dalal Bakul I. , Keown Paul A. , Paraskevas Frixos , Williams Gaynor , Johnston James B. 
Published: February 2007

AbstractWe report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T‐cells (CD5+, CD7+, CD16−, CD56−, CD57−, and CD41−), had monosomy 7, and secreted large amounts of Transforming Growth Factor‐β1(TGF‐β1). The serum levels of interleukins (IL)‐2, ‐2R, ‐6 and ‐8 were elevated, while the IL‐1<β, IL‐4, and tumor necrosis factor‐α were normal. © 1995 Wiley‐Liss, Inc.
Dexamethasone in the treatment of meningeal leukemia
Authors: Gómez‐Almaguer David , González‐Llano Oscar , Montemayor Jorge , Jaime‐Pérez José C. , Galindo Cesar 
Published: February 2007

AbstractTo determine if dexamethasone has a role in the treatment of meningeal leukemia, 8 consecutive patients with acute lymphoblastic and signs or symptoms of CNS were included in the study. After the confirmation of leukemic blast cells on cerebrospinal fluid, they received intrathecal and IV dexamethasone; 3 days later the patients received “triple” intrathecal chemotherapy with dexamethasone, methotrexate and cytarabine, and the spinal fluid was studied again. All patients had good clinical response and 7 out of the 8 patients showed reduction on the CSF cell count after the use of dexamethasone alone. The results suggest that dexamethasone is a lympholytic agent that could play a more active role in the prevention and therapy of meningeal leukemia and should be preferred over hydrocortisone in the so called “triple” intrathecal chemotherapy for the prevention and treatment of CNS leukemia. © 1995 Wiley‐Liss, Inc.
Hb lulu island (α2β2107[G9]Gly→Asp)‐β°‐thalassemia (codon 15; TGG → TAG), a form of thalassemia intermedia
Authors: Gray G. R. , Manson H. E. , Gu L‐H. , Ye. Leonova J. , Huisman T. H. J. 
Published: February 2007

AbstractHb Lulu Island [β107(G9)Gly → Asp] was discovered in an East Indian female who carried a common β°‐thalassemia allele, i.e., codon 15, TGG → TAG (is a stop codon) in trans. Both abnormalities were detected through sequencing of the amplified β‐globin genes and were confirmed by hybridization with 32P‐labeled probes. Hb Lulu Island is mildly unstable with a borderline decrease in oxygen affinity; its instability is less severe than that of Hb Burke or β107(G9)Gly → Arg. The compound heterozygosity expresses as a thalassemia intermedia with moderate anemia, a variable need for blood transfusions, Heinz body formation, and a red cell morphology which is typical for such a condition. The level of HbA2 was greatly increased (6.5–7.0%) as was the δ chain level (12% of total non‐α) probably because of the instability of Hb Lulu Island and the decreased ability of the βx chain to form dimers with the normal α chain.
Clinical and histological features retain their prognostic impact under interferon therapy of CML: A pilot study
Authors: Thiele Juergen , Kvasnicka Hans Michael , Niederle Norbert , Kloke Otto , Schmidt Marcus , Lienhard Heiko , Zirbes Thomas , Meuter Raoul Boris , Leder Lutz Dietrich , Fischer Robert 
Published: February 2007

AbstractIn 55 patients with Ph1+ CML under interferon (IFN) monotherapy, an immunohistochemical and morphometric study on pretreatment bone marrow biopsies was performed to evaluate the prognostic impact of clinical as well as histological disease features. For identification of megakaryocytes we used the PAS stain and CD61 to calculate the subtraction of precursors (pro‐ and megakaryoblasts). Demonstration of macrophages and their different subsets was carried out by PG‐M1 (CD68) and the GSA‐I lectin. The erythroid precursors were stained by Ret40f (anti‐glycophorin C). Density of argyrophilic (reticulin plus collagen) fibers was determined by applying Gomori's silver impregnation method. Clinical variables like state of hematological response to IFN administration, age, spleen and liver size, myeloblasts plus promyelocytes, basophils as well as basophils and eosinophils exerted a predictive capacity by univariate statistical analysis. However, when entering these factors into previously published risk models, i.e., the so‐called Sokal score and its modifications, to assess subgroups with different survival patterns or relative risk groups, a clear‐cut discrimination was not feasible. Bone marrow features of prognostic value consisted of megakaryocytes and their precursors, fibers, and pro‐ and erythroblasts. Only when including histological variables into a formerly reported Cox model, could a significant separation of patients into the different categories or relative risk groups be computated. In conclusion, the present data emphasize the prognostic impact of histological parameters to be considered in all clinical trials on CML.
In vitro and in vivo myelotoxicity of CAI to human and murine hematopoietic progenitor cells
Authors: Volpe Donna A. , Cole Kristina , Sandeen Mary Ann , Kohn Elise C. 
Published: February 2007

AbstractCarboxyamido‐triazole (CAI), an agent that targets calcium‐sensitive signal transduction pathways, has both antiproliferative and antimetastatic properties. The objective of this study was to evaluate the myelotoxicity of CAI to normal human and murine hematopoietic cells. In vitro toxicity of CAI was determined by inhibition of myeloid [colony‐forming unitgranulocyte/macrophage (CFU‐gm)] and erythroid [burst‐forming unit‐erythroid (BFU‐e)] colony formation in clonal assays. The effects of oral CAI on CD2F1 mouse marrow and splenic cellularity, marrow progenitor content, and peripheral blood cell counts were assessed in relation to plasma CAI levels. In vitro, CAI caused a concentration‐dependent inhibition of CFU‐gm and BFU‐e colonies following continuous drug exposure. Murine CFU‐gm and BFU‐e were inhibited > 90% by 10 and 15 μg/mL CAI, respectively. However, suppression of human CFU‐gm and BFU‐e did not exceed 65% at the same concentrations. In vivo, CAI reduced the number of CFU‐gm and BFU‐e per femur after the initial dose and through day 4. Variations in colony inhibition paralleled changes in CAI plasma concentrations. While colony inhibition increased in vitro with escalating drug concentrations, this was not observed in vivo with additional CAI doses. The low toxicity of CAI in vivo combined with the significant difference between toxicity for human and mouse progenitors in vitro suggests a relatively low adverse potential to the bone marrow for this new signal transduction inhibitory agent.
High‐density lipoprotein fails to inhibit serotonin‐induced activation of blood platelets
Authors: Pfennig Olaf , Zhao Bin , Frye Sabine , Dierichs Rolf 
Published: February 2007

AbstractHigh‐density lipoprotein (HDL) of 100–400 μg/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1–5 μM). Highly concentrated HDL (1,200 μg/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist‐induced platelet activation.
A single episode of neonatal seizures permanently alters glutamatergic synapses
Authors: Cornejo Brandon J. , Mesches Michael H. , Coultrap Steven , Browning Michael D. , Benke Timothy A. 
Published: February 2007

AbstractObjectiveThe contribution of seizures to cognitive changes remains controversial. We tested the hypothesis that a single episode of neonatal seizures (sNS) on rat postnatal day (P) 7 permanently impairs hippocampal‐dependent function in mature (P60) rats because of long‐lasting changes at the synaptic level.MethodssNS was induced with subcutaneously injected kainate on P7. Learning, memory, mossy fiber sprouting, spine density, hippocampal synaptic plasticity, and glutamate receptor expression and subcellular distribution were measured at P60.ResultssNS selectively impaired working memory in a hippocampal‐dependent radial arm water‐maze task without inducing mossy fiber sprouting or altering spine density. sNS impaired CA1 hippocampal long‐term potentiation and enhanced long‐term depression. Subcellular fractionation and cross‐linking, used to determine whether glutamate receptor trafficking underlies the alterations of memory and synaptic plasticity, demonstrated that sNS induced a selective reduction in the membrane pool of glutamate receptor 1 subunits. sNS induced a decrease in the total amount ofN‐methyl‐D‐aspartate receptor 2A and an increase in the primary subsynaptic scaffold, PSD‐95.InterpretationThese molecular consequences are consistent with the alterations in plasticity and memory caused by sNS at the synaptic level. Our data demonstrate the cognitive impact of sNS and associate memory deficits with specific alterations in glutamatergic synaptic function. Ann Neurol 2007
Synthesis, Structure and Properties of the High‐Pressure Modifications of the Ternary Compounds LnPtSn (Ln: La, Pr, Sm).
Authors: Riecken Jan F. , Rodewald Ute Ch. , Heymann Gunter , Rayaprol Sudhindra , Huppertz Hubert , Hoffmann Rolf‐Dieter , Poettgen Rainer 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Energetics of Cobalt Phosphate Frameworks: α, β, and Red NaCoPO4.
Authors: Le So‐Nhu , Eng Hank W. , Navrotsky Alexandra 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile High‐Yield Solvothermal Route to Tin Phosphide Sn4P3.
Authors: Kovnir Kirill A. , Kolen'ko Yury V. , Ray Sugata , Li Jinwang , Watanabe Tomoaki , Itoh Mitsuru , Yoshimura Masahiro , Shevelkov Andrei V. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Structure, Magnetic Susceptibility and Moessbauer and Raman Spectroscopies of the New Oxyphosphate Fe0.50TiO(PO4).
Authors: Benmokhtar S. , El Jazouli A. , Chaminade J. P. , Gravereau P. , Wattiaux A. , Fournes L. , Grenier J. C. , Waal. D. Waal. D. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ag2CuMnO4: A New Silver Copper Oxide with Delafossite Structure.
Authors: Casan‐Pastor Nieves , et al. et al. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Application of Organolithium and Related Reagents in Synthesis. Part 31. Effective Conversion of 3‐Arylphthalides into 2‐(1‐Aryl‐3‐oxo‐4‐alkoxycarbonylbutyl)benzoic Acids.
Authors: Bieniek Adam , Kulikiewicz Krystyna K. , Bartczak Monika M. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solvent‐Free Bromination of 1,3‐Diketones and β‐Keto Esters with NBS.
Authors: Pravst Igor , Zupan Marko , Stavber Stojan 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Halide‐Free Ethylation of Phenol by Multifunctional Catalysis Using Phosphinite Ligands.
Authors: Carrion M. Carmen , Cole‐Hamilton David J. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regiospecific Phenyl Esterification to Some Organic Acids Catalyzed by Combined Lewis Acids.
Authors: Roy H. N. , Al Mamun A. H. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Chiral Hydroxylated Cyclopentanones and Cyclopentanes.
Authors: Niidu Allan , Paju Anne , Eek Margus , Mueuerisepp Aleksander‐Mati , Pehk Tonis , Lopp Margus 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Promoted Cross‐Coupling of Acid Chlorides with Arylboronic Acids: A Convenient Method for Preparing Aromatic Ketones.
Authors: Polackova Viera , Toma Stefan , Augustinova Iveta 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Efficient and General Method for the Ring‐Opening of Aziridines with Various Nucleophiles in DMSO.
Authors: Wu Jie , Sun Xiaoyu , Sun Wei 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structural Study of Tetrahydroindazolones.
Authors: Claramunt Rosa M. , Lopez Concepcion , Perez‐Medina Carlos , Pinilla Elena , Torres M. Rosario , Elguero Jose 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of Aryl and Heteroaroyl‐Substituted Hydroxypyrazolines from the Reactions of β‐Alkoxyvinyl Trichloromethyl Ketones with Heteroarylhydrazides.
Authors: Bonacorso Helio G. , Oliveira Marli R. , Costa Michelle B. , Drekener Roberta L. , da Silva Leticia B. , Zanatta Nilo , Martins Marcos A. P. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Synthesis of 2‐Alkylthio‐5,5‐dimethyl‐4H‐imidazol‐4‐ones.
Authors: Yuan Ju‐Zhen , Wei Jia‐Jia , Ding Ming‐Wu 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N,N,N′,N′‐Tetrabromobenzene‐1,3‐disolfonamide (TBBDS) as an Efficient Promoter for One‐Pot Conversion of N‐Arylglycines to Sydnones in the Presence of NaNO2/Ac2O under Neutral Conditions.
Authors: Azarifar Davood , Ghasemnejad‐Bosra Hassan , Ghorbani‐Vaghei Ramin , Tajbaksh Mahmood 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.