bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the predictive value of late gadolinium enhancement assessed by cardiac magnetic resonance on sudden cardiac death in patients selected for implantable cardioverter defibrillator and cardiac resynchronization therapy implantation: a systematic review and meta-analysis
Authors: Masszi Richárd , Zsigmond Előd-János , Ehrenberger Réka , Turan Caner , Fehérvári Péter , Teutsch Brigitta , Molnár Zsolt , Drobni Zsófia , Vágó Hajnalka , Hegyi Péter , Merkely Béla , Kosztin Annamária 
Published: April 2024

Abstract
Aims
Late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance (CMR) can evaluate myocardial scar associated with a higher risk of sudden cardiac death (SCD), which can guide the selection between cardiac resynchronization therapy with or without a defibrillator (CRT-P/CRT-D). Our aim was to investigate the association between LGE and SCD risk in patients with CRT using the LGE-CMR technique.

Methods and results
We performed a systematic literature search using four databases. The target population was CRT candidates. The primary endpoint was SCD. The risk of bias was assessed using the QUIPS tool.
Fifteen eligible articles were included with a total of 2494 patients, of whom 27%, 56%, and 19% had an implantable cardioverter defibrillator (ICD), CRT-D, and CRT-P, respectively. Altogether, 54.71% of the cohort was LGE positive, who had a 72% higher risk for SCD (HR 1.72; 95% CI 1.18–2.50) compared to LGE negatives. In non-ischemic patients, the proportion of LGE positivity was 46.6%, with a significantly higher risk for SCD as compared to LGE negatives (HR 2.42; 95% CI 1.99–2.94). The subgroup of CRT-only patients showed no difference between the LGE-positive vs. negative candidates (HR 1.17; 95% CI 0.82–1.68). Comparable SCD risk was observed between articles with short- (OR 7.47; 95% CI 0.54–103.12) vs. long-term (OR 6.15; 95% CI 0.96–39.45) follow-up time.

Conclusion
LGE-CMR positivity was associated with an increased SCD risk; however, in CRT candidates, the difference in risk reduction between LGE positive vs. negative patients was statistically not significant, suggesting a role of reverse remodeling. LGE-CMR before device implantation could be crucial in identifying high-risk patients even in non-ischemic etiology.

Graphical abstract
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
Authors: Lüsebrink Enzo , Gade Nils , Seifert Paula , Ceelen Felix , Veit Tobias , Fohrer Fabian , Hoffmann Sabine , Höpler Julia , Binzenhöfer Leonhard , Roden Daniel , Saleh Inas , Lanz Hugo , Michel Sebastian , Schneider Christian , Irlbeck Michael , Tomasi Roland , Hatz Rudolf , Hausleiter Jörg , Hagl Christian , Magnussen Christina , Meder Benjamin , Zimmer Sebastian , Luedike Peter , Schäfer Andreas , Orban Martin , Milger Katrin , Behr Jürgen , Massberg Steffen , Kneidinger Nikolaus 
Published: April 2024

Abstract
Background and aims
Candidate selection for lung transplantation (LuTx) is pivotal to ensure individual patient benefit as well as optimal donor organ allocation. The impact of coronary artery disease (CAD) on post-transplant outcomes remains controversial. We provide comprehensive data on the relevance of CAD for short- and long-term outcomes following LuTx and identify risk factors for mortality.

Methods
We retrospectively analyzed all adult patients (≥ 18 years) undergoing primary and isolated LuTx between January 2000 and August 2021 at the LMU University Hospital transplant center. Using 1:1 propensity score matching, 98 corresponding pairs of LuTx patients with and without relevant CAD were identified.

Results
Among 1,003 patients having undergone LuTx, 104 (10.4%) had relevant CAD at baseline. There were no significant differences in in-hospital mortality (8.2% vs. 8.2%, p > 0.999) as well as overall survival (HR 0.90, 95%CI [0.61, 1.32], p = 0.800) between matched CAD and non-CAD patients. Similarly, cardiovascular events such as myocardial infarction (7.1% CAD vs. 2.0% non-CAD, p = 0.170), revascularization by percutaneous coronary intervention (5.1% vs. 1.0%, p = 0.212), and stroke (2.0% vs. 6.1%, p = 0.279), did not differ statistically between both matched groups. 7.1% in the CAD group and 2.0% in the non-CAD group (p = 0.078) died from cardiovascular causes. Cox regression analysis identified age at transplantation (HR 1.02, 95%CI [1.01, 1.04], p < 0.001), elevated bilirubin (HR 1.33, 95%CI [1.15, 1.54], p < 0.001), obstructive lung disease (HR 1.43, 95%CI [1.01, 2.02], p = 0.041), decreased forced vital capacity (HR 0.99, 95%CI [0.99, 1.00], p = 0.042), necessity of reoperation (HR 3.51, 95%CI [2.97, 4.14], p < 0.001) and early transplantation time (HR 0.97, 95%CI [0.95, 0.99], p = 0.001) as risk factors for all-cause mortality, but not relevant CAD (HR 0.96, 95%CI [0.71, 1.29], p = 0.788). Double lung transplant was associated with lower all-cause mortality (HR 0.65, 95%CI [0.52, 0.80], p < 0.001), but higher in-hospital mortality (OR 2.04, 95%CI [1.04, 4.01], p = 0.039).

Conclusion
In this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up.
Triggering antibacterial activity of a common plant by biosorption of selected heavy metals
Authors: Kováčová Mária , Bodnár Yankovych Halyna , Augustyniak Adrian , Casas-Luna Mariano , Remešová Michaela , Findoráková Lenka , Stahorský Martin , Čelko Ladislav , Baláž Matej 
Published: April 2024

AbstractThe presented study proposes an efficient utilization of a common Thymus serpyllum L. (wild thyme) plant as a highly potent biosorbent of Cu(II) and Pb(II) ions and the efficient interaction of the copper-laden plant with two opportunistic bacteria. Apart from biochars that are commonly used for adsorption, here we report the direct use of native plant, which is potentially interesting also for soil remediation. The highest adsorption capacity for Cu(II) and Pb(II) ions (qe = 12.66 and 53.13 mg g−1, respectively) was achieved after 10 and 30 min of adsorption, respectively. Moreover, the Cu-laden plant was shown to be an efficient antibacterial agent against the bacteria Escherichia coli and Staphylococcus aureus, the results being slightly better in the former case. Such an activity is enabled only via the interaction of the adsorbed ions effectively distributed within the biological matrix of the plant with bacterial cells. Thus, the sustainable resource can be used both for the treatment of wastewater and, after an effective embedment of metal ions, for the fight against microbes.
Graphical abstract
Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and periodontal status in children and adolescents with nonsyndromic cleft lip and palate. Systematic literature review and meta-analysis
Authors: Escobar-Arregocés Francina , Eras Mayra-Alexandra , Bustos Andrea , Suárez-Castillo Angela , García-Robayo Dabeiba-Adriana , del Pilar Bernal Maria 
Published: April 2024

Abstract
Objective
To identify the characteristics of the oral microbiota and the relationship of the dental caries and periodontal status in patients aged 0 to 18 years with non-syndromic cleft lip and palate (CLP).

Materials and methods
A systematic review of the literature was carried out. Five databases were consulted, including publications in English, Spanish and Portuguese. The evaluations of the quality of the observational studies and the experimental studies were carried out with the Newcastle–Ottawa scale and CONSORT guidelines, respectively. The risk of bias of the studies was determined using Rev Manager 5.4, and 5 publications were meta-analyzed.

Results
The cariogenic microbiota of children and adolescents with cleft lip and palate was similar to that of children without clefts, although with higher counts of Streptococcus mutans and Lactobacillus spp. The periodontopathogenic microbiota was related to the presence of Campylobacter spp, Fusobacterium spp, Fusobacterium nucleatum, Prevotella intermedia/nigrescens, Parvimonas micra and Porphyromonas gingivalis, considered microorganisms with high pathogenic capacity. Heterogeneity was shown in relation to the microbiota and the type of fissure, presenting numerous microorganisms associated with the pre- and post-surgical condition (cheilorrhaphy and palatorrhaphy) such as Staphylococcus aureus, Streptococcus beta hemolyticus, Klebsiella pneumoniae and Klebsiella oxytoca, Moraxella catarrhalis, Candida spp, Candida albicans, Candida krusei and Candida tropicalis. The meta-analysis revealed that patients with cleft lip and palate were 2.03 times more likely to have caries than the control group (p<0.005).

Conclusion
In the microbiota, there was a great diversity of microorganisms that can vary according to the type of fissure and surgical interventions predisposing patients to a greater probability of dental caries, it is important to take into account the technique used to describe the oral microbiota in order to be able to compare the different studies.

Clinical relevance
Studying the microbiota and the relationship of dental caries and periodontal status in children and adolescents with cleft lip and palate can facilitate the comprehensive care of patients with these conditions.
Genetic aspects of ataxias in a cohort of Turkish patients
Authors: Gogus Basak , Elmas Muhsin , Turk Boru Ulku 
Published: April 2024

Abstract
Introduction
Ataxia is one of the clinical findings of the movement disorder disease group. Although there are many underlying etiological reasons, genetic etiology has an increasing significance thanks to the recently developing technology. The aim of this study is to present the variants detected in WES analysis excluding non-genetic causes, in patients with ataxia.

Methods
Thirty-six patients who were referred to us with findings of ataxia and diagnosed through WES or other molecular genetic analysis methods were included in our study. At the same time, information such as the onset time of the complaints, consanguinity status between parents, and the presence of relatives with similar symptoms were evaluated. If available, the patient’s biochemical and radiological test results were presented.

Results
Thirty-six patients were diagnosed through WES or CES. The rate of detected autosomal recessive inheritance disease was 80.5%, while that of autosomal dominant inheritance disease was 19.5%. Abnormal cerebellum was detected on brain MRI images in 26 patients, while polyneuropathy was detected on EMG in eleven of them. While the majority of the patients were compatible with similar cases reported in the literature, five patients had different/additional features (variants in MCM3AP, AGTPBP1, GDAP2, and SH3TC2 genes).

Conclusions
The diagnosis of ataxia patients with unknown etiology is made possible thanks to these clues. Consideration of a genetic approach is recommended in patients with ataxia of unknown etiology.
Ability of NAD and Sirt1 to epigenetically suppress albuminuria
Authors: Hasegawa Kazuhiro , Tamaki Masanori , Shibata Eriko , Inagaki Taizo , Minato Masanori , Yamaguchi Sumiyo , Shimizu Ikuko , Miyakami Shinji , Tada Miho , Wakino Shu 
Published: April 2024

AbstractThe time for diabetic nephropathy (DN) to progress from mild to severe is long. Thus, methods to continuously repress DN are required to exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability of nicotinamide adenine dinucleotide (NAD) and its metabolites to reduce albuminuria through Sirt1- or Nampt-dependent epigenetic regulation. We previously reported that proximal tubular Sirt1 was lowered before glomerular Sirt1. Repressed glomerular Sirt1 was found to epigenetically elevate Claudin-1. In addition, we reported that proximal tubular Nampt deficiency epigenetically augmented TIMP-1 levels in Sirt6-mediated pathways, leading to type-IV collagen deposition and diabetic fibrosis. Altogether, we propose that the Sirt1/Claudin-1 axis may be crucial in the onset of albuminuria at the early stages of DN and that the Nampt/Sirt6/TIMP-1 axis promotes diabetic fibrosis in the middle to late stages of DN. Finally, administration of NMN, an NAD precursor, epigenetically potentiates the regression of the onset of DN to maintain Sirt1 and repress Claudin-1 in podocytes, suggesting the potential use of NAD metabolites as epigenetic medications for DN.
Modelling antecedent soil hydrological conditions to improve the prediction of landslide susceptibility in typhoon-prone regions
Authors: Abancó Clàudia , Asurza Flavio Alexander , Medina Vicente , Hürlimann Marcel , Bennett Georgina L. 
Published: April 2024

AbstractMost regional landslide susceptibility models do not consider the evolving soil hydrological conditions leading up to a multiple occurrence regional landslide event. This results in inaccurate predictions due to the non-linear behaviour of the terrain. To address this, we have developed a simple and efficient model that incorporates the mid-term evolution of soil hydrological conditions. The model combines a water balance model and a geotechnical model based on infinite slope theory. The analysis of 561 high-intensity rainfall events in a typhoon-prone region of the Philippines revealed that the percolation of water during the 5-month wet season is crucial in determining landslide susceptibility. Consequently, high-intensity rainfall events at the start of the wet season are less likely to trigger landslides, while later events are more hazardous. We analysed the change in landslide susceptibility during the 2018 rainy season by comparing the probability of failure (PoF) before and after three high-intensity rainfall events (July, August and September). Only the event in September caused a significant increase in the probability of failure (PoF). The model showed an accuracy of 0.63, with stable cells better represented than unstable cells. The antecedent hydrological conditions on the lower soil layers are responsible for changes in landslide susceptibility. Our findings support the hypothesis that new approaches to developing hydro-meteorological thresholds for landslide early warning systems should be evaluated, especially in regions with strong seasonality.
Motives of Therapists for Using Routine Outcome Monitoring (ROM) and How it is Used by Them in Clinical Practice: Two Qualitative Studies
Authors: Azizian Kia Shaghayegh , Wittkampf Lisette , van Lankeren Jacobine , Janse Pauline 
Published: April 2024

AbstractDespite its demonstrated value, many mental health institutions struggle to implement progress feedback effectively. There is also insufficient information about how therapists utilize progress feedback. To gain more insight, two qualitative studies were conducted. The first study compared the attitudes and motives of therapists who used and those who did not use progress feedback. The second study examined how psychologists incorporated progress feedback into their practice. In total, 23 therapists were interviewed, and the data were analyzed using thematic analysis. The first study found that almost all the therapists had a positive attitude about progress feedback. Those who did not use it indicated reasons such as a heavy workload and patient-related factors, and they also lacked sufficient information about the potential benefits of progress feedback. The second study revealed four major ways in which the therapists utilized feedback, namely: supporting actions to discuss progress feedback, discussing progress feedback with patients, modifications in the ongoing treatment, and peer consultation. However, discussions during peer consultations about using progress feedback for patients who were not benefitting from treatment and how the treatment might be adjusted accordingly were often lacking. In conclusion, it is crucial that training and education be provided to therapists on how to use progress feedback effectively. Having regular discussions about progress feedback during peer consultations could also facilitate its integration into clinical practice.
Symbiosexual Attraction: An Integrated Mixed-Methods Study
Authors: Johnston Sally W. 
Published: April 2024

AbstractA recent review of cultural and academic discourse presented evidence that some people experience attraction to two (or more) people in a preexisting relationship. This phenomenon, symbiosexuality, is understudied in the field of sexuality. Lack of recognition and validation for this attraction, including in the polyamorous community, may be negatively impacting those who experience symbiosexual attraction. I conducted an integrated mixed-methods analysis of secondary data from the 2023 The Pleasure Study to learn more about symbiosexual attraction. Findings from this study support the hypothesis that people experience symbiosexual attraction, which they describe as an attraction to the energy, multidimensionality, and power shared between people in relationships. Further, findings from this study indicate that a diverse group of people experience symbiosexual attraction and, while unanticipated, symbiosexual attraction can be a strong, frequent, and/or pervasive experience. These findings push the boundaries of the concepts of desire and sexual orientation in sexuality studies and challenge the ongoing invisibility and invalidation of and stigma and discrimination against such attractions, within both the polyamorous community and our broader mononormative culture.
The Influence of Religious Identification on Strategic Green Marketing Orientation
Authors: Casidy Riza , Arli Denni , Tan Lay Peng 
Published: April 2024

AbstractSmall and medium-sized enterprises (SMEs) play a critical role in the green economy due to their significant environmental footprint. Because more than 84% of the world’s population identifies with a religion, most SME top-executives are likely to identify with a religion that would influence their decision-making. Despite these recent advances, prior studies have focused on SMEs’ external drivers and did not consider the role of internal drivers, such as the characteristics of SMEs’ top-executives, in influencing green marketing strategy. We aim to address this gap by focusing on religious identification as a key driver of green marketing by SMEs. Specifically, we examine the effects of top-executives’ religious identification on strategic green marketing orientation (SGMO), and how such effects are moderated by political ideology. Using respondents comprised of CEO and/or owner-managers of SMEs in the US, the results show empirical evidence supporting the importance of religious identification in influencing green marketing decisions. Moreover, we found that the effects of religious identification on SGMO are more pronounced among top-executives with Conservative ideology.
Gender-Based Violence and Carceral Feminism in Australia: Towards Decarceral Approaches
Authors: Loney-Howes Rachel , Longbottom Marlene , Fileborn Bianca 
Published: April 2024

AbstractThis article explores the limitations of criminal legal responses to gender-based violence in Australia, specifically sexual assault law reforms and the criminalisation of coercive control. We demonstrate that carceral horizons deployed to address gender-based violence cause further harm to survivors and overshadow diverse perceptions and practices of justice. We suggest that such an approach is inappropriate and dangerous in the Australian context, given the historical and enduring harms of colonisation and the extent to which the actors within and the structure of the criminal legal system perpetrate violence towards Indigenous survivors of gender-based violence. Drawing on insights from research on survivors’ justice needs, survivors’ experiences in the criminal legal system, and abolitionist, transformative, and Indigenous scholarship, we discuss the potential for alternative ways of conceptualising justice responses in the Australian context that move beyond and avoid further perpetuating the harms arising from criminal legal responses to gender-based violence.
The Contribution of Willingness to Communicate to L2 Learners’ Depth of Vocabulary Knowledge: An Empirical Study
Authors: Heidari Kamal 
Published: April 2024

AbstractThe issues of depth vocabulary knowledge and Willingness to Communicate (henceforth, WTC) are among the most important issues in second language learning. The present study set out to empirically look into the contribution of WTC to depth of vocabulary knowledge in L2 learning. To this end, 88 English L2 learners, divided into two groups in terms of their WTC, were given two depth vocabulary tests. The Word Association Test (WAT) was first administered to make a comparison between the depth vocabulary knowledge of the two WTC groups. Then, to triangulate the results, the Word Part Levels Test (WPLT) was administered to check whether the obtained results confirmed those of WAT. Analyzing data through independent t-test and MANOVA indicated that learners with higher levels of WTC had deeper vocabulary knowledge than those with lower levels of WTC on the WAT. Further, the triangulation results evinced that although the two groups did not differ significantly on the form-section and meaning-section of the WPLT, they significantly differed on the use-section of the test. The relevant pedagogical implications of the study are discussed.
Investigation of pin and perforated heatsink cooling efficiency and temperature distribution
Authors: Göksu Taha Tuna 
Published: April 2024

AbstractThe uneven temperature distribution resulting from thermal stresses in heat sinks is a significant issue in modern electronic devices. This numerical investigation utilizes fluid to analyze the cooling, flow, and heat transfer characteristics of eight different heat sink designs. These include pin–fin heat sinks with circular, triangular, square, and hexagonal cross-sections, as well as their perforated versions. The results show that the thermal resistance range for all geometries was between Rth = 0.29 and 0.51 K W−1. The circular cross-section pin structure was found to be the most efficient in terms of thermal resistance, while the triangular perforated structure was the least efficient. The narrow and low temperature distribution indicates a high cooling potential for the heat sink. It has been observed that the temperature range studied is between 308.732 and 315.273 K. The circular cross-section pin structure is most efficient in terms of homogeneous distribution between 308.73 and 311.306 K. The pin-type structure with a square cross-section attained the maximum Performance Evaluation Criteria (PEC) of 1.1872 at P = 689 Pa, while the pin-type structure with a triangular cross-section attained the lowest PEC of 0.67 at P = 2750 Pa. The investigation revealed that, in relation to PEC, perforated structures had superior performance compared to other pin designs, except for the square-section pin structure. This research found that measuring the efficiency of a heat sink based just on thermal resistance or average temperature distribution is not enough; the PEC criteria must also be taken into account.