bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reservoir recovery study with stability analysis model constructed by flat sand filling experiment-Example of well area X in Tankou oilfield
Authors: Yang Yuan 
Published: March 2024

Abstract
Injecting and recovering fluids in mature oil fields is a challenging task that can have significant impact on overall recovery rates. Conventionally, the approach taken has been a combination of laboratory experiments and numerical simulations, which lack field-scale verification and prediction accuracy. To address this limitation, we propose a new methodological approach—from experimentation to data simulation to developing a solution proposal to mathematically proving the validity of the approach. The novelty of this approach lies in its ability to fast-track verification of the solution and to predict, within limitations, the expected performance under real-field conditions. In the case study detailed in this paper, we establish the relationship between permeability, crude oil viscosity, and fluid recovery rate—all key parameters—on recovery performance, assuming a fixed wellbore network configuration. The results are validated through numerical simulations. Based on these findings, we recommend a development adjustment scheme, which is then rapidly validated using a reliability analysis model for a period of one year. The scheme implementation results in exponential distribution percentiles of 0.258375 and 0.276978, indicating its effectiveness. Additionally, the DGM (1,1) model projects recovery rates of 8.93 and 12.08 for the next two time points. Based on these projections, engineering guidelines are developed recommending crude oil viscosity adjustment through blending and dosing, and adoption of a 5 mL/min water injection rate for optimal recovery performance.
Influence of environmental variables on plant mite assemblages: implications on bio-control strategies in Tropical scenario
Authors: Mitra Subhasree , Acharya Shelley , Ghosh Sujay 
Published: March 2024

Abstract

The seasonal variation in mite populations on four selected plants, namely Justicia adhatoda L., Wissadula periplocifolia (L.) Thwaites, Citrus maxima (Burm.) Merr. and Syzygium jambolanum (Lam.) DC from tropical agro-climatic zone in India has been studied. Temperature (°C), rainfall (24 hrs in mm), relative humidity (at 08:30 hrs and 17:30 hrs) were considered as predictor variables to analyze various ecological attributes of the mite populations. A consecutive two years (September 2015 to 2017) study at three different time points, viz pre-monsoon, Monsoon and Post-monsoon succeeded to sample 13,210 mites speciemens from these four host plants. The study revealed that the occurrence of mite species was strongly correlated with habitats, temperature, rainfall and humidity across the seasons. Pre-monsoon, Monsoon and Post-monsoon times were shown to have significant influence on the dynamics of mite communities. The result suggested that the mite assemblages are correlated with their host plant types, environmental variables and seasonal factors. This finding helps us in designing mite control strategies in different seasons in Southern West Bengal, India. Depending of the result of our study and of other, one can design strategy of the biological control of pest mite using the predatory mites at different seasons and can obtain more economic benefit in term of greater crop production in Tropical scenario.
Bimodality in subaqueous dune height suggests critical transition at high flow
Authors: de Lange Sjoukje , de Vijsel Roeland van , Torfs Paul , Hoitink A.J.F. (Ton) 
Published: March 2024

Abstract
River bedforms influence fluvial hydraulics by altering bed roughness. With increasing flow velocity, the riverbed transitions from a flat bed to ripples, dunes, and an upper stage plane bed. Although prior research notes increased bedform height variation with flow strength and rapid shifts between bed configurations, the latter remains understudied. This study reanalyzes data from earlier experiments, revealing a bimodal distribution of dune heights beyond a transport stage of 18. Dune heights flicker between a low and high alternative state, indicating critical transitions. Potentially triggered by local sediment outbursts, these shifts lead to dune formation before returning to a washed-out state. This flickering behavior challenges the adequacy of a single snapshot to capture the system's state, impacting field measurements and experimental designs, and questions the classical equilibrium equations in geomorphology. This study calls for further research to understand and quantify flickering behavior in sediment beds at high transport stages.
Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis
Authors: Tautuiaki Senilaite , Gojer Jerusha , Jayaprakash Ramya , Sharma Pankaja , Pook Chris , Foster Meika , Miles-Chan Jennifer , Mithen Richard , Ramzan Farha 
Published: March 2024

Abstract
Purpose
Piper excelsum (kawakawa), a vascular plant endemic to Aotearoa, New Zealand, is of cultural and medicinal importance to Māori. Presence of biologically active compounds in kawakawa may underpin its putative beneficial health properties, particularly its anti-inflammatory effects. However, no human studies on its anti-inflammatory effects exist.
Method
Blood samples from a crossover two-arm randomised controlled trial to assess the impact of ingesting kawakawa tea (4g leaves/250 mL hot-water) on postprandial plasma abundances of microRNAs (miRNA) involved in metabolic-related pathways and their respective gene and protein targets in healthy human volunteers (n = 26; Age; 33.6 ± 1.9 (yr) and BMI; 22.5 ± 0.4 (kg/m2)) compared to water control, were used for the analysis.
Results
Nine miRNAs showed significantly different abundances following the two interventions. The abundance of hsa-miR-17-5p, -21-5p, -320a-5p, let-7g-5p, -16-5p, -122-5p, and − 144-3p was upregulated in response to kawakawa intake compared to water and the expression of hsa-miR-221-3p and − 223-3p was downregulated in kawakawa intake compared to water over a120 min postprandial period. In-silico analysis indicated miRNA enrichment in metabolic-related pathways, such as apoptosis, cytokine signaling, MAPK signaling, and MTOR pathways. Furthermore, the postprandial expression of IL-8 (p = 0.03), IL-6 (p = 0.01) and PPAR-γ was significanly reduced following kawakawa consumption compared to water control. While as IL-6 cytokine was significantly increased at 120 min in the kawakawa intervention only compared to baseline.
Conclusion
These findings highlight the interconnected nature of metabolic regulation pathways and highlight the need for further intervention studies to explore the chronic anti-inflammatory effects of kawakawa.
Clinical Trial Registration: The clinical trial is registered with Australian New Zealand Clinical Trials Registry ( ACTRN12621000311853).
Is Geriatric Medicine Teaching Homogeneous? The Analysis of Geriatric Medicine Courses at Polish Undergraduate Medical Programmes.
Authors: Kupis Robert , Perera Ian Bernard , Targowski Tomasz , Gąsowski Jerzy , Piotrowicz Karolina 
Published: March 2024

Abstract

Purpose
We aimed to analyse the characteristics of geriatric courses offered to undergraduate medical students in higher educational institutions (HEIs) in Poland.
Methods
We searched the official websites of the HEIs offering the medical degree programmes and we directly contacted the dean’s offices and HEIs representatives to retrieve the relevant information. The documents were analysed for course content, teaching methods, duration, and recommended texts. We also checked the obtained curricula for the reference to of the learning objectives (LOs) related to geriatric medicine, selected from the currently endorsed Polish educational standards (ES) provided by the Ministry of Science and Higher Education.
Results
Geriatric medicine courses were obligatory at all included HEIs (n=19), but the courses differed in structure and content. The courses varied in duration from 11 to 60 hours and were primarily lecture-based. Simulation was utilized at only one HEI and e-learning at two institutions. Out of 315 LOs, we acknowledged only 9 as geriatric. They were not always found in all curricula. Two HEIs included self-described LOs in their curricula. Across all HEIs a total of 29 recommended texts (published between 1995 and 2021) were identified, including 2 English-language texts.
Conclusion
Geriatric medicine was a mandatory subject for medical students of the included HEIs. However, there was a lack of uniformity in the offered courses. This leaves room for the development of a unified undergraduate geriatrics curriculum to effectively address diverse geriatric issues. The importance of this matter is highlighted by demographic trends and workforce challenges.
M2 macrophages promote PD-L1 expression in triple-negative breast cancer via secreting CXCL1
Authors: Zhang Lifen , Gu Shanzhi , Wang Lu , Zhao Lin , Zhao Xinhan , Zhang Lingxiao 
Published: March 2024

Abstract

M2-like tumor-associated macrophages (M2-like TAMs) are known to play a significant role in the progression of triple-negative breast cancer (TNBC) by creating an immunosuppressive microenvironment. The aim of this study is to investigate the impact of M2 macrophages on TNBC and their association with PD-L1 expression. The results showed a high infiltration of M2 macrophages in TNBC tissue, which correlated positively with PD-L1 expression. Upon analyzing the expression of various cytokines in macrophages, it was found that CXCL1 showed abnormally high expression in M2 macrophages. CXCL1 specifically increased the expression of PD-L1 in TNBC cells. Notably, when CXCL1 or its receptor CXCR2 was silenced, the facilitation of PD-L1 expression by M2 macrophages was inhibited. Mechanistically, CXCL1 derived from M2 macrophages binding CXCR2 activated the PI3K/AKT/NF-κB signaling pathway, generating increased PD-L1 expression in TNBC. To validate these findings, xenograft tumor models were employed, demonstrating a positive correlation between CXCR2, phospho-AKT, phospho-p65 and PD-L1 expression with treatment with M2 macrophages in the xenograft tumor tissue. Broadly speaking, these results provide evidence for the immunosuppressive role of M2 macrophages and CXCL1 in tumor cells, suggesting their potential as therapeutic biomarkers for TNBC.
Investigation of the Davey-Stewartson excitation in a plasma with Fermi-Dirac distributed electrons
Authors: Mohammadnejad Mohsen , Abdikian Alireza , Akbari-Moghanjoughi Masoud 
Published: March 2024

Abstract
In this research a comprehensive investigation of ion acoustic waves within plasma environments, utilizing the Fermi-Dirac electron distribution is presented. The reductive perturbation technique is used to derive the three-dimensional Davey-Stewartson equation and analytical solutions are found in Jacobi elliptic cnoidal and solitary traveling wave forms. The dynamic behaviors of the solutions are then analyzed and studied parametrically. It is believed that current research can significantly contribute to present understanding of nonlinear wave behavior in multispecies warm and dense plasma systems and can have diverse applications to astrophysical and laboratory plasmas. Our investigation using a detailed numerical analysis, focuses on the impact of the generalized Equation of State (EoS) for Fermi-Dirac electron-ion plasma with three-dimensional Davey-Stewartson solutions with in-depth analysis of the modulation instability of the ion acoustic excitations. Current study incorporates variety of plasma parameters, such as the normalized chemical potential and electron temperature, also exploring electron number density effect on the wide range electron density-temperature regime. This work advances current understanding of traveling wave solution behavior, the modulation stability affected by the propagation angle, and the instability growth rate providing a comprehensive insight into ion acoustic wave dynamics in plasmas.
Optilume BPH: 2-Year Results from A Prospective Multicenter Randomized Clinical Trial for the Treatment of Benign Prostatic Hyperplasia (The PINNACLE Study)
Authors: Kaplan Steven , Moss Jared , Freedman Sheldon 
Published: March 2024

Abstract

Background Patient outcomes were assessed 2 years after treatment with the Optilume BPH Catheter System, a minimally invasive surgical therapy for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).Methods One-hundred forty-eight adult males with symptomatic BPH were enrolled and randomized in a 2:1 fashion to Optilume BPH or Sham (100 Optilume BPH; 48 Sham). Long-term measures include International Prostate Symptom Score (IPSS), peak urinary flow rate (Qmax), Post-Void Residual Urine (PVR), quality of life measures and sexual function. Long term follow-up was limited to those treated with Optilume BPH.Results At 2 years, 67.5% (56/83 CI 56.3%, 77.4%) of participants in the Optilume BPH arm were symptomatic responders as defined by ≥ 30% improvement in IPSS without medical or surgical retreatment. IPSS significantly improved from 23.4 ± 5.5 to 11.0 ± 7.0. Qmax improved by 118.5% (8.9 ± 2.2 to 19.1 ± 16.3), while PVR showed a slight reduction (83.3 ± 70.6 to 67.2 ± 74.2). Improvement in uroflowmetry measures was consistent across all prostate volumes. BPH-II improved from 7.0 ± 2.9 to 2.3 ± 2.5 at 1 year and remained consistent at 2.3 ± 2.9 at the 2-years, representing a 53.9% improvement. IPSS QoL also improved from 4.6 ± 1.3 at baseline to 2.2 ± 1.5. The most common adverse events reported in the Optilume BPH arm were hematuria and urinary tract infection (UTI). No device and/or treatment related serious adverse events were reported occurring beyond 12 months post-procedure. There was no impact to sexual function.Conclusions In the PINNACLE study, participants treated with the Optilume BPH Catheter System demonstrated continued and durable results at 2 years, affirming tolerability, safety, and the enduring effectiveness of the outcomes. The Optilume BPH Catheter System provides long-lasting results that are comparable to the more invasive therapy options, while preserving the advantages with being a minimally invasive therapy.
Characterization of a colistin resistant, hypervirulent hospital isolate of Acinetobacter courvalinii from Canada
Authors: Sykes Ellen ME , Mateo-Estrada Valeria , Muzaleva Anna , Zhanel George , Dettman Jeremy , Chapados Julie , Gerdis Suzanne , Akineden Ömer , Castillo-Ramírez Santiago , Khan Izhar UH , Kumar Ayush 
Published: March 2024

Abstract

Non-baumannii Acinetobacter spp. are becoming more prevalent in clinical settings including those that present resistance to last-resort antibiotics such as colistin. AB222-IK40 is an Acinetobacter courvalinii strain isolated from a Canadian hospital. To our knowledge, it is the first report of clinical A. courvalinii in Canada. This isolate was collected from the Ottawa Hospital Research Institute located in Ottawa, Canada. Based on the susceptibility profiles (MICs), AB222-IK40 is resistant to colistin and non-susceptible to ertapenem. Whole-genome sequencing allowed for genomic investigation into colistin resistance mechanisms. No previously identified mechanism(s) were observed, but a mobile colistin resistance (mcr)-like gene and a UDP-glucose dehydrogenase gene were identified. Based on phylogenomic analyses, the mcr-like gene is an intrinsic phosphoethanolamine transferase. This gene family is involved in one of the many mechanisms responsible for colistin resistance in Acinetobacter baumannii. UDP-glucose dehydrogenase is involved in colistin resistance in Enterobacterales and has been characterized in capsule formation in A. baumannii. Global lipidomics reveal phosphatidyl-myo-inositol and lyso-phosphatidyl ethanolamine moieties in the membrane in greater abundance than in A. baumannii. Lipidomic profiles show differences that may be responsible for the colistin resistance phenotype in AB222-IK40. As this is the first report of A. courvalinii from a hospital in Canada, this species may be an emerging clinical pathogen, and therefore, it is important to understand this mechanism of colistin resistance.
Hyperspectral estimation of net photosynthetic rate of winter wheat under different water and nitrogen supplies
Authors: Dai Menglei , Gu Limin , Zhang Baoyuan , Bao Xiaoyuan , Cui Yuxuan , Sun Qian , Zhang Mingzheng , Qu Xuzhou , Sun Xuguang , Zhen Wenchao , Gu Xiaohe 
Published: March 2024

Abstract

Photosynthesis is a vital physiological activity in winter wheat that directly influences the production and accumulation of biomass. The net photosynthetic rate is a key indicator of photosynthetic capacity. Measuring the net photosynthetic rate using traditional methods can be challenging for high-throughput real-time monitoring. Reflectance spectroscopy has been shown to predict the physiological activities of crops and can track the physiological traits. This study focused on using leaf hyperspectral reflectance to estimate the net photosynthetic rate of winter wheat under different water and nitrogen supplies. At first, we transformed the raw spectral reflectance into relevant vegetation indices and extracted sensitive features using Competitive Adaptive Reweighted Sampling (CARS) and Successive Projections Algorithm (SPA). Then, estimation models for the net photosynthetic rate were constructed using Random Forest (RF) and Partial Least Squares Regression (PLSR) methods. Finally, the performance of the eight estimation models was compared using coefficient of determination (R2) and Root Mean Square Error (RMSE). The results showed that transforming raw spectral reflectance into vegetation indices significantly improved model performance. RF showed notably higher accuracy than PLSR. The VI-SPA-RF model was most accurate, with an R2 of 0.9429 for the training set and 0.7784 for the validation set. Therefore, the leaf hyperspectral data can be used for nondestructive monitoring of the net photosynthetic rate of winter wheat in real-time.
Stepping on shells. An experimental archaeological soil micromorphology study of trampling on a modern shell midden at Swifterkamp
Authors: Kleijne Jos , Kamstra Hester , Ens Steven van 
Published: March 2024

Abstract

In this paper we report the study of shell midden taphonomy using archaeological soil micromorphology on an experimentally constructed shell midden. Using common cockle shells, and two different cooking techniques (boiling and roasting), we study the changes occurring in the shells, and in the soil below the shells. Our aim is to provide a clearer picture of trampling and various cooking techniques on prehistoric shell middens. Examples from Northern European contexts are provided as a comparison to our experimental analysis.
Alzheimer's Disease Diagnosis By 3D-SEConvNeXt
Authors: Hu Zhongyi , Wang Yuhang , Xiao Lei 
Published: March 2024

Abstract

To address the challenge of early diagnosis of Alzheimer's disease (AD), this study proposes the 3D-SEConvNeXt model. This model combines ConvNeXt with 3D convolution and introduces the 3D-SE attention module for early AD classification tasks. The experimental data is obtained from the publicly available ADNI database, and the raw Magnetic Resonance Imaging (MRI) data is preprocessed using SPM12. The preprocessed data is then fed into the 3D-SEConvNeXt network for four classification tasks: AD/NC, MCI/NC, AD/MCI, and AD/MCI/NC. The performance of the proposed model is compared with other AD classification models. The experimental results demonstrate that the 3D-SEConvNeXt model consistently outperforms the other models in terms of accuracy, achieving excellent results in early AD diagnosis tasks.
Breathing dysfunction as a meaningful and measurable aspect of health in Rett Syndrome: A caregivers perspective
Authors: Wright Robert , Leonard-Corzo Krista S. , Li Jessica , Blankenship Jennifer M. , Richards Jennifer , Coenraads Monica , Hehn Jana , Lyden Kate , Clay Ieuan 
Published: March 2024

Abstract
Background
Although recent clinical trials have fueled optimism around the potential to develop novel therapies for Rett syndrome (RTT), further work is needed to identify and develop novel outcomes and measures. Breathing dysfunction is a prevalent symptom of RTT and is associated with several adverse outcomes (e.g., risk of sudden death, exacerbation of other symptoms). Yet, no studies have examined the meaningfulness and acceptability of measuring breathing dysfunction from the perspectives of caregivers. Thus, the purpose of this study was to qualitatively examine breathing dysfunction as a meaningful and measurable aspect of health in individuals with RTT.
Methods
We conducted semi-structured interviews (N = 13) with caregivers of individuals with RTT to explore experiences with and preferences for digitally measuring breathing dysfunction. We performed thematic analysis grounded in theory to examine major themes.
Results
Analysis of the interviews resulted in three main themes for experiences with breathing dysfunction: (1) meaningfulness, with three subthemes identified: does not want to become worse/wants to prevent, wants to improve, and emotional relevance; (2) impact with three subthemes identified: magnitude of impact, impact on daily activities, and impact on quality of life; and (3) connecting with other symptoms. Analysis of the interviews with respect to preferences for digitally measuring breathing dysfunction resulted in two main themes: (1) conditional willingness; and (2) benefits of digital measurement.
Conclusion
To capture meaningfulness and preferences for measuring symptoms, it is important to hear what aspects of health are important to patients and caregivers living with the symptoms. Caregivers reported that breathing dysfunction was meaningful and resulted in significant impacts on their child’s lives as well as theirs and their families. Further, caregivers reported they would be willing to digitally measure their child’s breathing dysfunction and that it would be beneficial for the “greater good” of therapeutic development. Identifying breathing dysfunction as a meaningful and measurable aspect of health for individuals with RTT is critical and lays the groundwork for guiding the development and testing of future clinical trials for managing breathing dysfunction.