bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food density drives diet shift of the invasive mysid shrimp, Limnomysis benedeni
Authors: Rani Varsha , Horváth Zsófia , Nejstgaard Jens C. , Fierpasz Ádám , Pálffy Károly , Vad Csaba F. 
Published: April 2024

AbstractUnderstanding the diet preferences and food selection of invasive species is crucial to better predict their impact on community structure and ecosystem functioning. Limnomysis benedeni, a Ponto‐Caspian invasive mysid shrimp, is one of the most successful invaders in numerous European river and lake ecosystems. While existing studies suggest potentially strong trophic impact due to high predation pressure on native plankton communities, little is known of its food selectivity between phyto‐ and zooplankton, under different food concentrations. Here, we therefore investigated the feeding selectivity of L. benedeni on two commonly occurring prey organisms in freshwaters, the small rotifer zooplankton Brachionus calyciflorus together with the microphytoplankton Cryptomonas sp. present in increasing densities. Our results demonstrated a clear shift in food selection, with L. benedeni switching from B. calyciflorus to Cryptomonas sp. already when the two prey species were provided in equal biomasses. Different functional responses were observed for the two food types, indicating somewhat different foraging mechanisms for each food type. These findings provide experimental evidence on the feeding flexibility of invasive mysid shrimps and potential implications for trophic interactions in invaded ecosystems.
Intranasal administration of unadjuvanted SARS‐CoV‐2 spike antigen boosts antigen‐specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters
Authors: Agbayani Gerard , Akache Bassel , Renner Tyler M. , Tran Anh , Stuible Matthew , Dudani Renu , Harrison Blair A. , Duque Diana , Bavananthasivam Jegarubee , Deschatelets Lise , Hemraz Usha D. , Régnier Sophie , Durocher Yves , McCluskie Michael J. 
Published: April 2024

AbstractWith the continued transmission of SARS‐CoV‐2 across widely vaccinated populations, it remains important to develop new vaccines and vaccination strategies capable of providing protective immunity and limiting the spread of disease. Heterologous prime‐boost vaccination based on the selection of different vaccine formulations and administration routes for priming and booster doses presents a promising strategy for inducing broader immune responses in key systemic and respiratory mucosal compartments. Intranasal vaccination can induce mucosal immune responses at the site of SARS‐CoV‐2 infection; however, the lack of clinically approved mucosal adjuvants makes it difficult to induce robust immune responses with protein subunit vaccines. Herein, we evaluated the immunogenicity of heterologous prime‐boost regimens in mice and hamsters based on a parenteral vaccination of the antigen in combination with sulfated lactosylarchaeol (SLA) archaeosomes, a liposome adjuvant comprised of a single semisynthetic archaeal lipid, followed by an intranasally administered unadjuvanted SARS‐CoV‐2 spike antigen. Intranasal administration of unadjuvanted spike to mice and hamsters increased serum spike‐specific IgG titers and spike‐neutralizing activity compared with nonboosted animals. Spike‐specific IgA responses were also detected in the bronchoalveolar lavage fluid in the lungs of mice that received an intranasal boost. In hamsters, the intranasal boost showed high efficacy against SARS‐CoV‐2 infection by protecting from body weight loss and reducing viral titers in the lungs and nasal turbinate. Overall, our heterologous intramuscular prime‐intranasal boost with SLA‐adjuvanted and unadjuvanted spike, respectively, demonstrated the potential of protein subunit formulations to promote antigen‐specific systemic and mucosal immune responses.
Experimental Study on the Migration and Distribution of Microplastics in Desert Farmland Soil Under Drip Irrigation
Authors: Du Ao , Hu Can , Wang Xufeng , Zhao Yachuan , Xia Wenhao , Dai Xianxing , Wang Long , Zhang Shufeng 
Published: April 2024

Abstract
The microplastics (MPs) formed by broken plastic film may migrate in the soil under drip irrigation. To investigate the migration distribution of MPs in desert farmland soil under drip irrigation conditions, our study was conducted on farmland in Xinjiang (China). A MP drip irrigation penetration migration testing device was set up in combination with Xinjiang farmland irrigation methods to conduct a migration simulation experiment. The results showed that the migration amount of MPs in soil was significantly positively correlated with the amount of drip irrigation, and significantly negatively correlated with the soil depth; in addition, the relationship between the migration amount of MPs in different types of soil was: clay &lt; sandy loam &lt; sandy soil. Under drip irrigation conditions, the migration rates of MPs were 30.51%, 19.41%, and 10.29% in sandy soil, sandy loam soil, and clay, respectively. The migration ability of these three particle sizes of polyethylene MPs in soil was ranked as follows: 25 to 147 μm &gt; 0 to 25 μm &gt; 147 to 250 μm. When the drip irrigation volume was 2.6 to 3.2 L, horizontal migration distances of MPs exceeded 5 cm, and vertical migration distances reached more than 30 cm. Our findings provide reference data for the study of soil MP migration. Environ Toxicol Chem 2024;43:1250–1259. © 2024 SETAC
Determinants of compliance to iron folate supplementation among pregnant women attending antenatal care in public health facilities of South West Ethiopia: A case‐control study
Authors: Shumi Lensa , Gedefa Abdi Geda , Bidira Kebebe 
Published: April 2024

AbstractBackgroundThe prevalence of anemia among pregnant women remains high globally, particularly in low‐income settings. Iron and folic acid supplementation (IFAS) during pregnancy is the most widely employed strategy to alleviate adverse pregnancy outcomes. This study aimed to explore the determinants of compliance with iron supplementation in the study area.AimTo identify determinants of IFAS compliance among pregnant women attending antenatal care (ANC) in Mettu town, South West Ethiopia, in 2021.MethodsA facility‐based, unmatched case‐control study was conducted from May to July 2021 with a total sample size of 344 (115 cases and 229 controls). Cases and controls were selected using systematic random sampling. Data was collected using a structured, pretested interviewer‐administered questionnaire, entered into Epi‐data software version 3.1, and exported to SPSS version 23 for analysis. Variables with p < 0.25 during bivariate analyses were entered into a multivariable logistic regression model. Then, variables with a p < 0.05 at 95% confidence interval (CI) were declared to be statistically significant determinants of IFAS. The odds ratio was used to indicate the strength of the association.ResultHaving Previous history of anaemia (adjusted odds ratio [AOR] = 5.8, 95% CI [2.5−13.6], p < 0.01), having good knowledge about IFAS (AOR = 3.3, 95% CI [1.7−6.7], p < 0.001), being a government employee (AOR = 5.2 [2.4−11.5], p < 0.01], and receiving counseling service during ANC (2.495% CI [1.3−4.7] p < 0.01) were among determinants of adherence to IFAS.ConclusionsMaternal knowledge about IFAS, counseling about IFAS, occupation, and history of anaemia were found to be significantly associated factors with compliance with iron folate supplementation during pregnancy. This implies that adherence to IFAS can be improved through improving maternal knowledge about importance of IFAS, quality counseling services and strengthening an overall ANC follow‐up services.
Demographic, clinical, and surgical features of patients undergoing thyroidectomy due to thyroid lesions in Southern Iran: A cross‐sectional study
Authors: Mardani Parviz , Koulaian Sepehr , Fouladi Damoun , Rajaie Ramsheh Fatemeh Sadat , Amirian Armin , Shahriarirad Sepehr , Malekhosseini Seyed Ali , Shahriarirad Reza 
Published: April 2024

AbstractBackground and AimsThe incidence of thyroid cancer has witnessed a significant global increase and stands as one of the most prevalent cancers in Iran. This surge is primarily attributed to the escalating incidence of papillary thyroid cancer (PTC), with overdiagnosis emerging as an equally noteworthy factor. Consequently, this study aims to ascertain the incidence of thyroid cancer, along with its clinical presentation, demographic characteristics, and surgical features in patients undergoing thyroid surgery.MethodsThis cross‐sectional study involved the evaluation of patient files from referral centers in Shiraz spanning the years 2015−2020. Demographic and clinical information pertaining to thyroid cancer was extracted and subsequently analyzed using SPSS software.ResultsA total of 533 documented cases of thyroid cancer undergoing surgery revealed an annual rate of 89 cases in our location. The average age of the patients was 43.9 ± 13.4 years (ranging from 13 to 92), with females constituting 429 (83.5%) of the cases, and 278 (54.1%) being malignant. Conventional PTC emerged as the most prevalent pathology, accounting for 239 (45.0%) of the cases. Patients with thyromegaly exhibited significantly higher incidences of nonmalignant tumors (p = 0.01), while those with malignant tumors were notably younger than those with nonmalignant tumors (p = 0.001).ConclusionOur study revealed a progressive rise in the number of patients undergoing thyroidectomy over the years, with PTC constituting the majority of cases. Malignant cases were more frequently observed in younger patients, and in smaller lesion sizes, highlighting the importance of early screening and optimizing detection methods, especially in high‐risk populations.
Measuring the cost‐effectiveness of treating rectovaginal and vesicovaginal fistulas: A multicenter global study by the Fistula Foundation
Authors: Rajagopal Keerthana , Pollaczek Lindsey , Chu Jesse , Mann Hannah 
Published: April 2024

AbstractObjectiveSurgery for obstetric fistula is a highly effective treatment to restore continence and improve quality of life. However, a lack of data on the cost‐effectiveness of this procedure limits prioritization of this essential treatment. This study measures the effectiveness of fistula surgeries using disability‐adjusted life years (DALYs) averted.MethodsIn 2021 and 2022, the Fistula Foundation funded 20 179 fistula surgeries and related procedures at 143 hospitals among 27 countries. We calculated DALYs averted specifically for vesicovaginal fistula and rectovaginal fistula procedure types (n = 13 235 surgeries) by using disability weights from the 2019 Global Burden of Disease study. We based cost calculations on direct treatment expenses, including medical supplies, health provider fees, and preoperative and postoperative care. We measured effectiveness using data on the risk of permanent disability, country‐specific average life spans, and treatment outcomes.ResultsThe total treatment cost was $7.6 million, and a total of 131 433 DALYs were averted. Thus, the cost per DALY averted—the cost to restore 1 year of healthy life—was $58. For this analysis, we took a cautious approach and weighted only surgeries that resulted in a closed fistula with restored continence. We calculated DALYs averted by country. Limitations of the study include data entry errors inherent in patient logs and lack of long‐term outcomes.ConclusionThe current study demonstrates that obstetric fistula surgery, along with having a significant positive impact on maternal health outcomes, is highly cost‐effective in comparison with other interventions. The study therefore highlights the benefits of prioritizing fistula treatment as part of the global agenda for maternal health care.
Effect of a Declined Plasma Concentration of Valproic Acid Induced by Meropenem on the Antiepileptic Efficacy of Valproic Acid
Authors: Gu Chunping , Zhang Yongfang , Yuan Fumiao , Huang Kaibin , Lin Zhenzhou , Chen Qiong , Chen Yan , Wu Yongming , Wang Dongmei , Wang Shengnan 
Published: April 2024

ABSTRACTObjectiveThis study aimed to indicate whether a declined plasma concentration of valproic acid (VPA) induced by co‐administration of meropenem (MEPM) could affect the antiepileptic efficacy of VPA.MethodsWe retrospectively reviewed data of hospitalized patients who were diagnosed with status epilepticus or epilepsy between 2010 and 2019. Patients co‐administered VPA and MEPM during hospitalization were screened and assigned to the exposure group, while those co‐administerd VPA and other broad‐spectrum antibiotics were allocated to the control group.ResultsThe exposure group and control group included 50 and 11 patients, respectively. With a similar dosage of VPA, the plasma concentration of VPA significantly decreased during co‐administration (24.6 ± 4.3 μg/mL) compared with that before co‐administration (88.8 ± 13.6 μg/mL, p < 0.0001), and it was partly recovered with the termination of co‐administration (39.8 ± 13.2 μg/mL, p = 0.163) in the exposure group. The inverse probability of treatment weighting estimated the treatment efficacy via changes in seizure frequency, seizure duration, and concomitant use of antiepileptic drugs, which were not significantly different between the exposure and control groups. In the exposure group, there was no significant differences in seizure frequency between the periods of before‐during and before‐after (p = 0.074 and 0.153, respectively). Seizure duration during VPA–MEPM co‐administration was not significantly different from that before co‐administration (p = 0.291).ConclusionsIn this study, the reduced plasma concentration of VPA induced by the co‐administration of MEPM did not affect the antiepileptic efficacy of VPA. This conclusion should be interpreted with caution, and more research is warranted.Trial RegistrationChinese Clinical Trial Registry: ChiCTR2000034567. Registered on 10 July 2020
Assessment of CYP‐Mediated Drug Interactions for Enasidenib Based on a Cocktail Study in Patients with Relapse or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Authors: Cheng Yiming , Wang Xiaomin , Ghosh Atalanta , Pu Jie , Carayannopoulos Leonidas N , Li Yan 
Published: April 2024

AbstractAs a selective and potent inhibitor targeting the isocitrate dehydrogenase‐2 (IDH2) mutant protein, enasidenib obtained approval from the US Food and Drug Administration (FDA) in 2017 for adult patients with acute myeloid leukemia (AML) with an IDH2 mutation. In vitro investigations demonstrated that enasidenib affects various drug metabolic enzymes and transporters. This current investigation aimed to assess enasidenib on the pharmacokinetics (PKs) of CYP substrates, including dextromethorphan (CYP2D6 probe drug), flurbiprofen (CYP2C9 probe drug), midazolam (CYP3A4 probe drug), omeprazole (CYP2C19 probe drug), and pioglitazone (CYP2C8 probe drug), in patients with AML or myelodysplastic syndrome. Results showed that following the co‐administration of enasidenib (100 mg, once daily) for 28 days, the PK parameters AUC(0‐∞) and Cmax of dextromethorphan increased by 1.37 (90% confidence interval (CI): 0.96, 1.96) and 1.24 (90% CI: 0.94, 1.65)‐fold, respectively, compared to dextromethorphan alone. For flurbiprofen, these parameters increased by 1.14 (90%CI: 1.01, 1.29) and 0.97 (90% CI 0.86, 1.08)‐fold, respectively, when compared to flurbiprofen alone. Conversely, midazolam exhibited decreases to 0.57 (90% CI 0.34, 0.97) and 0.77 (90% CI 0.39, 1.53)‐fold, respectively, in comparison to midazolam alone. The parameters for omeprazole increased by 1.86 (90% CI: 1.33, 2.60) and 1.47 (0.93, 2.31)‐fold, respectively, compared to omeprazole alone, while those for pioglitazone decreased to 0.80 (90% CI: 0.62, 1.03) and 0.87 (90% CI: 0.65, 1.16)‐fold, respectively, in comparison to pioglitazone alone. These findings provide valuable insights into dose recommendations concerning drugs acting as substrates of CYP2D6, CYP2C9, CYP3A4, CYP2C19, and CYP2C8 when administered concurrently with enasidenib.
Jumping into recovery: A systematic review and meta‐analysis of discriminatory and responsive force plate parameters in individuals following anterior cruciate ligament reconstruction during countermovement and drop jumps
Authors: Labban Wasim , Manaseer Thaer , Golberg Eric , Sommerfeldt Mark , Nathanail Stephanie , Dennett Liz , Westover Lindsey , Beaupre Lauren 
Published: April 2024

AbstractPurposeComprehensive understanding of force plate parameters distinguishing individuals postprimary anterior cruciate ligament reconstruction (ACLR) from healthy controls during countermovement jumps (CMJ) and/or drop jumps (DJ) is lacking. This review addresses this gap by identifying discriminative force plate parameters and examining changes over time in individuals post‐ACLR during CMJ and/or DJ.MethodsWe conducted a systematic review and meta analyses following the Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) guidelines. Nine databases were searched from inception to March 2022. We included cross‐sectional papers comparing post‐ACLR with healthy controls or longitudinal studies of individuals at least 6 months postprimary ACLR while performing CMJ and/or DJ on force plates. The methodological quality was appraised using the Modified Downs and Black Checklist.ResultsThirty‐three studies including 1185 (50.38%) participants post‐ACLR, and 1167 (49.62%) healthy controls, were included. Data were categorised into single‐leg CMJ, double‐leg CMJ, single‐leg DJ, and double‐leg DJ. Jump height was reduced in both single (mean difference [MD] = −3.13; p < 0.01; 95% confidence interval [CI]: [−4.12, −2.15]) and double‐leg (MD = −4.24; p < 0.01; 95% CI: [−5.14, −3.34]) CMJs amongst individuals with ACLR. Similarly, concentric impulse and eccentric/concentric impulse asymmetry could distinguish between ACLR (MD = 3.42; p < 0.01; 95% CI: [2.19, 4.64]) and non‐ACLR (MD = 5.82; p < 0.01; 95% CI: [4.80, 6.80]) individuals. In double‐leg DJs, peak vertical ground reaction forces were lower in the involved side (MD = −0.10; p = 0.03; 95% CI: [−0.18, −0.01]) but higher in the uninvolved side (MD = 0.15; p < 0.01; 95% CI: [0.10, 0.20]) when compared to controls and demonstrated significant changes between 6 months and 3 years post‐ACLR.ConclusionThis study identified discriminative kinetic parameters when comparing individuals with and without ACLR and also monitored neuromuscular function post‐ACLR. Due to heterogeneity, a combination of parameters may be required to better identify functional deficits post‐ACLR.Level of EvidenceLevel III.
Etrolizumab as an induction and maintenance therapy for ulcerative colitis: A systematic review and meta‐analysis of randomized controlled trials
Authors: Saleh Othman , Abuelazm Mohamed T. , Mohamed Islam , Ramadan Alaa , Assaf Mohammad , Alzoubi Ahmad , AlBarakat Majd M. , Abdelazeem Basel 
Published: April 2024

AbstractBackground and AimEtrolizumab is a gut‐targeted anti‐β7 integrin monoclonal antibody. However, the evidence of etrolizumab efficacy and safety in ulcerative colitis remains inconclusive. Therefore, we aim to evaluate the safety and efficacy of etrolizumab as an induction and maintenance therapy for active moderate to severe ulcerative colitis.MethodsWe synthesized randomized controlled studies (RCTs) from MEDLINE, Scopus, EMBASE, PubMed, Web of Science, and Cochrane Library until April 2023. The risk ratio (RR) for dichotomous outcomes with the corresponding 95% confidence interval (CI) was used. The study protocol was registered in PROSPERO with ID: CRD42023437040.ResultsFive RCTs with 1849 participants were included. The etrolizumab group had a significant clinical response (RR: 1.28 with 95% CI [1.08, 1.51], P = 0.005), clinical remission rates during the induction phase (RR: 2.47 with 95% CI [1.48, 4.11], P = 0.0005), compared with the placebo group in ulcerative colitis; however, there was no statistically significant difference between the two groups, regarding the corticosteroids‐free remission rate (RR: 1.92 with 95% CI [0.94, 3.92], P = 0.07). Moreover, endoscopic improvement, endoscopic remission, and histologic remission rates were observed more in the etrolizumab group during both the induction and maintenance phases. For safety outcomes, etrolizumab was significantly safer, but any adverse event was higher in the etrolizumab group than in the placebo.ConclusionEtrolizumab shows its effectiveness as both an induction and maintenance therapy for moderate or severe UC. The findings demonstrate its positive impact on clinical, endoscopic, and histologic remission rates. Regarding safety, other than any side effects, etrolizumab showed a good safety than a placebo.
Chaordic event co‐creation and tourism destination image: Strategic carnival shifts in the post‐pandemic era
Authors: Pappas Nikolaos , Glyptou Kyriaki , Karadimitriou Christina 
Published: April 2024

AbstractMajor street events, such as carnivals, offer a unique opportunity for destination experience value co‐creation by participants which relates directly to the destination image. This study uses service‐dominant logic (SDL) to consider the effects of event co‐creation on destination image from the point of view of a participatory process rather than from an outcome perspective. Drawing from a sample of 400 street event participants in the Patras Carnival in Greece, it examines the complexity aspects of co‐creational experience and its influence upon the destination image of the host city. Those aspects are examined by means of fuzzy‐set qualitative comparative analysis. The findings revealed three sufficient configurations (co‐creational involvement and satisfaction; co‐creational event image; experience‐satisfaction nexus) that could affect the destination image of the host destination. The paper contributes to the theoretical body of experiential co‐creational approaches to destination image with clear managerial implications for both event organizers and destination managers.
Optimal Treatment Parameters for Ultrasound‐Stimulated Microbubbles in Upregulating Proliferation and Stemness of Bone Marrow Mesenchymal Stem Cells
Authors: Chen Beibei , Zhu Qiong , Duan Mao , Li Qinglong , Wang Gong , Guan Xue , Yu Pu , Xu Xiaoxun , He Ying , Xu Yali 
Published: April 2024

ObjectivesUltrasound‐targeted microbubble disruption (UTMD) is a widely used technique to improve the differentiation and proliferation capacity of mesenchymal stem cells (MSCs), but the optimal therapeutic parameters for UTMD are unclear. In this study, we aimed to find the appropriate peak negative pressure (PNP), which is a key parameter for enhancing the stemness properties and proliferation of MSCs.MethodsExperiments were performed in UTMD group, ultrasound (US) group under different PNP exposure conditions (0.5, 1.0, and 1.5 MPa), and control group. Apoptosis safety was analyzed by flow cytometry and MSC proliferation was measured at 12, 24, and 36 hours after irradiation by cell counting kit 8. The expression of the stemness genes NANOG, OCT‐4, and SOX‐2 were determined by enzyme‐linked immunosorbent assay (ELISA) or reverse transcription polymerase chain reaction.ResultsThe results showed that the 1.5 MPa UTMD‐treated group had the highest proliferation capacity of MSCs at 24 hours. ELISA or quantitative reverse transcription polymerase chain reaction results showed that UTMD treatment of the 1.5 MPa group significantly upregulated the expression of the stemness genes NANOG, SOX‐2, and OCT‐4.ConclusionsIn conclusion, the appropriate peak PNP value of UTMD was 1.5 MPa, and 1.5 MPa‐mediated UTMD group obviously promoted MSCs proliferation and maintained stemness by upregulating the expression of stemness genes.