bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ação educativa: integrando prática assistencial e investigação sobre o acidente de trabalho com material biológico
Authors: Freitas Paula Hübner , Silva Rosângela Marion da , Centenaro Alexa Pupiara Flores Coelho , Stekel Lilian Medianeira Coelho , Costa Kamila Caneda da , Zorzi Carolina Simonetti 
Published: February 2025

Objetivo: promover e analisar ação educativa sobre o acidente de trabalho com material biológico por meio da articulação entre prática assistencial e investigação. Método: pesquisa convergente assistencial, realizada entre novembro de 2021 e abril de 2022 em um hospital localizado no Rio Grande do Sul. Participaram enfermeiros plantonistas e representantes dos setores de apoio e comissões. A proposta metodológica foi distribuída nas fases de concepção, instrumentação, perscrutação, análise e interpretação. Para a coleta de dados utilizaram-se pesquisa documental, entrevista semiestruturada e grupos de convergência. A análise seguiu as etapas de apreensão, síntese, teorização e transferência. Resultados: identificou-se subestimação do risco, denotando invisibilidade acerca do acidente. A partir da sugestão dos participantes, foi realizada ação educativa sobre o correto descarte de resíduos perfurocortantes. Considerações finais: a reflexão dos participantes sobre o acidente e a elaboração de ação educativa configuram-se como possibilidade para tornar a prática assistencial mais segura.
Preoperative peripheral nerve blocks are not independently associated with improved functional outcome, patient satisfaction, or risk of chronic pain at one year following knee arthroplasty
Authors: Clement Nick D. , Qaddoura Bilal , Coppola Andrew , Akram Nimra , Pendyala Sai , Jones Samantha , Afzal Irrum , Kader Deiary F. 
Published: February 2025

AimsControl of acute pain following knee arthroplasty (KA) with a perioperative peripheral nerve block (PNB) may improve functional outcomes and reduce the risk of chronic postoperative knee pain (CPKP). The aims of this study were to assess whether a PNB influences patient-reported outcomes and risk of CPKP at one year following KA.MethodsA retrospective study was conducted over a two-year period and included 3,338 patients who underwent KA, of whom 1,434 (43.0%) had a lower limb PNB. A total of 2,588 patients (77.6%) completed and returned their one-year follow-up questionnaire. The Oxford Knee Score (OKS) and pain component (OKS-PS), EuroQol five-dimension questionnaire (EQ-5D), and EQ-visual analogue scale (VAS) were collected preoperatively and at one year postoperatively. Patient satisfaction was also recorded at one year. The OKS-PS was used to define CPKP at one year.ResultsThe PNB group were younger (mean difference (MD) 0.7 years, 95% CI 0.0 to 1.3; p = 0.039), had a worse OKS (MD 0.7, 95% CI 0.1 to 1.3; p = 0.027), and were more likely to have had a spinal anaesthesia relative to a general anaesthetic (odds ratio 4.2, 95% CI 3.23 to 5.45; p < 0.001). When adjusting for confounding factors, patients in the PNB group had a significantly reduced improvement in their OKS (MD -0.9, 95% CI -1.6 to -0.1; p = 0.022), which may not be clinically meaningful. There were no significant differences in the OKS-PS (p = 0.068), EQ-5D (p = 0.313), or EQ-VAS (0.855) between the groups when adjusting for confounding factors. When adjusting for confounding factors using binary regression analysis, there were no differences in patient satisfaction (p = 0.132) or in the risk of CPKP (p = 0.794) according to PNB group.ConclusionPNBs were independently associated with worse knee-specific outcomes, but whether these are clinically meaningful is not clear, as the difference was less than the minimal clinically important difference. Furthermore, PNBs were not independently associated with differences in health-related quality of life, patient satisfaction, or risk of CPKP.Cite this article: Bone Jt Open 2025;6(2):147–154.
Association of dietary niacin intake with all-cause mortality in chronic kidney disease: A retrospective cohort study of NHANES
Authors: Xiang Meijuan , Peng Jianyun , Gui Zhihong , Jin Ju , Meng Jinling 
Published: February 2025

Background
Dietary niacin intake has a positive influence on several chronic diseases, while the impact of dietary niacin intake on prognosis in chronic kidney disease (CKD) remains unknown. The study would explore the association between dietary niacin intake and all-cause mortality in CKD patients.

Methods
Data about 4,659 CKD patients in this retrospective cohort study were obtained from the National Health and Nutrition Examinations Survey (NHANES). Dietary niacin intake data were acquired based on the 24-hour dietary recall interviews. Weighted univariate Cox regression models were utilized to select potential covariates. The association of dietary niacin intake with all-cause mortality was explored using weighted univariate and multivariate Cox regression models. The results were presented as hazard ratios (HRs) with 95% confidence intervals (CIs).

Results
In total, 4,659 CKD patients were included in the study. The mean age of patients was 58.03 (0.42) years old, and 2,502 (58.45%) were female. During a mean follow-up of 73.92 (1.14) months, 1,325 (28.44%) CKD patients died. Compared to CKD patients with lower niacin intake ≤19mg, those with niacin intake >33 mg were associated with lower all-cause mortality risk (HR = 0.79, 95%CI: 0.64–0.98). The association also found in subgroups of age ≥65 years old (HR = 0.68, 95%CI: 0.53–0.88), males (HR = 0.68, 95%CI: 0.51–0.92), BMI <25 kg/m2 (HR = 0.63, 95%CI: 0.39–0.99), smoking (HR = 0.68, 95%CI: 0.49–0.94), dyslipidemia (HR = 0.71, 95%CI: 0.56–0.91), and non-hyperphosphatemia (HR = 0.73, 95%CI: 0.58–0.91).

Conclusion
Adequate dietary niacin intake was related to lower odds of all-cause mortality in CKD patients. Niacin supplements may have potential benefits for prognosis in CKD patients.
Highly sensitive molecular assay based on Identical Multi-Repeat Sequence (IMRS) algorithm for the detection of Trichomonas vaginalis infection
Authors: Shiluli Clement , Kamath Shwetha , Kanoi Bernard N. , Kimani Racheal , Oduor Bernard , M. Abkallo Hussein , Maina Michael , Waweru Harrison , Kamita Moses , Pamme Nicole , Dupaty Joshua , Klapperich Catherine M. , Lolabattu Srinivasa Raju , Gitaka Jesse 
Published: February 2025

Introduction
Annually, approximately 174 million people globally are affected by Trichomonas vaginalis (T. vaginalis) infection. Half of these infections occur in resource-limited regions. Untreated T. vaginalis infections are associated with complications such as pelvic inflammatory disease and adverse pregnancy outcomes mostly seen in women. In resource-limited regions, the World Health Organization (WHO) advocates for syndromic case management. However, this can lead to unnecessary treatment. Accurate diagnosis of T. vaginalis is required for effective and prompt treatment. Molecular tests such as Polymerase Chain Reaction (PCR) have the advantage of having a short turn-around time and allow the use of non-invasive specimens such as urine and vaginal swabs. However, these diagnostic techniques have numerous disadvantages such as high infrastructure costs, false negative and positive results, and interstrain variation among others. This study aimed to evaluate the use of identical multi-repeat sequences (IMRS) as amplification primers for developing ultrasensitive diagnostic for T. vaginalis.

Methods
We used genome-mining approaches based on identical multi-repeat sequences (IMRS) algorithm to identify sequences distributed on the T. vaginalis genome to design a primer pair that targets a total of 69 repeat sequences. Genomic T. vaginalis DNA was diluted from 5.8×102 to 5.8×10−4 genome copies/μl and used as a template in the IMRS-based amplification assay. For performance comparison, 18S rRNA PCR assay was employed.

Results
The T. vaginalis -IMRS primers offered a higher test sensitivity of 0.03 fg/μL compared to the 18S rRNA PCR (0.714 pg/μL). The limit of detection for the Isothermal assay was 0.58 genome copies/mL. Using real-time PCR, the analytical sensitivity of the T. vaginalis -IMRS primers was <0.01 pg/μL, equivalent to less than one genome copy/μL.

Conclusion
De novo genome mining of T. vaginalis IMRS as amplification primers serves as a platform for developing ultrasensitive diagnostics for Trichomoniasis and a wide range of infectious pathogens.
Simulation of the electrolyte imbalance in vanadium redox flow batteries
Authors: Zhang Baowen , Lei Yuan 
Published: February 2025

The stack is the core component of large-scale flow battery system. Based on the leakage circuit, mass and energy conservation, electrochemicals reaction in porous electrode, and also the effect of electric field on vanadium ion cross permeation in membrane, a model of kilowatt vanadium flow battery stack was established. The electro chemical reaction parameters, ion concentration and temperature of each single cell in the stack were calculated respectively. The imbalance of vanadium ion concentration and the effects of current density and electrolyte temperature on the electrolyte imbalance in the stack were studied.
Comparison of frailty instruments for predicting mortality and prolon ged hospitalization in acute coronary syndrome patients
Authors: Langsted Anne , Benatar Jocelyne , Kerr Andrew , Bloomfield Katherine , Devlin Gerry , Sasse Alexander , Smythe David , To Andrew , White Harvey , Wilkins Gerrard , Stewart Ralph 
Published: February 2025

Objective
To evaluate the relative strengths of 3 frailty assessment instruments for predicting mortality and prolonged hospitalization in acute coronary syndrome patients.

Design
Prospective cohort study.

Setting
Acute cardiac care units in New Zealand.

Participants
1174 patients >70 years of age hospitalized with an acute coronary syndrome.

Interventions
The Clinical Frailty Scale (CFS), Edmonton Frail Scale (EFS) and Fried Criteria (Fried), were completed during hospital admission following an acute coronary syndrome when the patient was clinically stable.

Primary and secondary outcome measures
All-cause mortality over the next ~5 years and hospitalization for >10 days in the next year determined from national administrative data.

Results
During median follow-up of 5.1 years there were 353 deaths. Harrell’s C-statistic for mortality for EFS was 0.663, Fried 0.648 and CFS 0.640 (p<0.001 for all). C-statistics for hospitalization >10 days (n = 267, 22%) were EFS 0.649, Fried 0.628, and CFS 0.584 (p<0.001 for all). Associations between increase in frailty scores and mortality were graded including in patients not classified as frail. The hazard ratio (HR) for mortality, adjusted for age and sex, for patients with an EFS score ≥9 (n = 197) compared to ≤2 (n = 331) was 5.0 (95% CI: 3.4–7.4). In models which included the Euroscore II or GRACE risk scores the EFS improved risk discrimination for both mortality and prolonged hospitalization more than the CFS and Fried.

Conclusion
In older patients assessed following an acute coronary syndrome the EFS discriminated the risk of all cause mortality and prolonged hospitalization better than the CFS and Fried tests, and improved risk discrimination when added to clinical risk scores.
Advanced retinal disease detection from OCT images using a hybrid squeeze and excitation enhanced model
Authors: Gencer Gülcan , Gencer Kerem 
Published: February 2025

Background
Retinal problems are critical because they can cause severe vision loss if not treated. Traditional methods for diagnosing retinal disorders often rely heavily on manual interpretation of optical coherence tomography (OCT) images, which can be time-consuming and dependent on the expertise of ophthalmologists. This leads to challenges in early diagnosis, especially as retinal diseases like diabetic macular edema (DME), Drusen, and Choroidal neovascularization (CNV) become more prevalent. OCT helps ophthalmologists diagnose patients more accurately by allowing for early detection. This paper offers a hybrid SE (Squeeze-and-Excitation)-Enhanced Hybrid Model for detecting retinal disorders from OCT images, including DME, Drusen, and CNV, using artificial intelligence and deep learning.

Methods
The model integrates SE blocks with EfficientNetB0 and Xception architectures, which provide high success in image classification tasks. EfficientNetB0 achieves high accuracy with fewer parameters through model scaling strategies, while Xception offers powerful feature extraction using deep separable convolutions. The combination of these architectures enhances both the efficiency and classification performance of the model, enabling more accurate detection of retinal disorders from OCT images. Additionally, SE blocks increase the representational ability of the network by adaptively recalibrating per-channel feature responses.

Results
The combined features from EfficientNetB0 and Xception are processed via fully connected layers and categorized using the Softmax algorithm. The methodology was tested on UCSD and Duke’s OCT datasets and produced excellent results. The proposed SE-Improved Hybrid Model outperformed the current best-known approaches, with accuracy rates of 99.58% on the UCSD dataset and 99.18% on the Duke dataset.

Conclusion
These findings emphasize the model’s ability to effectively diagnose retinal disorders using OCT images and indicate substantial promise for the development of computer-aided diagnostic tools in the field of ophthalmology.
Response of dorsal horn neurons in mice to high‐frequency (kHz) biphasic stimulation is not sensitive to local temperature rise
Authors: Karnup Sergei , Daugherty Stephanie , Tai Changfeng , Yoshimura Naoki 
Published: February 2025

AbstractClinically accepted for treatment of chronic pain 10 kHz‐frequency electric spinal cord stimulation (10 kHz‐SCS) releases more power in tissue compared to conventional low‐frequency (<100 Hz) stimulation due to increased duty cycle. This is equivalent to the release of more heat in a surrounding tissue, which may change the functional state of affected neural elements. In the case of SCS, plausible candidates to be affected by thermal a component of kHz‐frequency electric field stimulation (kHz‐FS) are dorsal column axons and neurons of the superficial layers of the dorsal horn. In this study, we tested the hypothesis that joule heat produced by kHz‐FS modulates neuronal excitability. In slices of the mouse spinal cord, we monitored membrane potential and membrane input resistance in neurons of lamina II during exposure to kHz‐FS. Surprisingly, we found no correlation between temperature rise and changes of membrane parameters. Furthermore, the depolarizing effect of kHz‐FS was always immediate and remained persistent throughout stimulation, whereas rise of temperature was delayed for 1–2 s and reached its saturation level within the following few seconds. Thus, we concluded that the thermal component has an insignificant role in the mechanism of kHz‐FS action.
Designing a meditation module to affect etiological and preventive factors in primary hypertensive patients—A pilot study
Authors: Goswami Sharma Kapila , Manjula S. D. , Kamath Shobha U. , Prabhu M. Mukhyaprana , Babu M. G. Ramesh , Bose Ujjal , Vasanthalaxmi K. 
Published: February 2025

AbstractThe aim of the present pilot study is to design, validate, and check the feasibility and efficacy of the designed meditation module on etiological and preventive factors in primary hypertensive patients (PHP). The systematic and detailed meditation module was formulated to prevent the complications of hypertension. The designed module was validated by 5 subject experts in the field of complementary and alternative therapy and research. Content Validity Ratio (CVR), Average Congruency Percentage (ACP), and Content Validity Index were calculated. The intervention was given for 5 days a week for 4 weeks, to 9 PHP to check the feasibility and the efficacy of the module by analyzing biochemical and psychological parameters. A randomized controlled trial is planned ahead with this module as intervention. The designed meditation module had 19 concepts with CVR >0.49 and ACP > 90% which were retained, 2 were modified (CVR 0.6, ACP 80) and 1 was deleted as CVR was <0.49 and ACP < 70%. The feasibility test mean was 93.33 ± 8.66 and the efficacy was tested by increase in the brain‐derived neurotrophic factor (BDNF) (p = 0.022) and decrease in anxiety (p = 0.022) and perceived stress (p = 0.016), improvement in emotional quotient (p = 0.011), mental state (p = 0.044), quality of sleep (p = 0.001), quality of life (p = 0.011), and happiness state (p = 0.003). The designed meditation module was found valid by the experts, feasible to patients, and efficient in improving biochemical and psychological parameters among PHP to affect the hypertensive etiological factors and check the progress and complications of the disorder.Trial Registration: CTRI/2022/09/045421
Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in females and males: MERITnI study
Authors: Apple Fred S. , Buda Kevin G. , Wagner Barrett P. , Sexter Anne , Sandoval Yader , Smith Stephen W. , Meyer Kylie , Ladd Alanna , Worrell Kathryn , Brown Hannah M. , Schulz Karen M. 
Published: February 2025

Abstract

Objectives
We examined the 0- and 2-h diagnostic performance of the Mindray high-sensitivity cardiac troponin I (hs-cTnI) assay using two predefined sex-specific 99th percentile upper reference limits (URL) in patients with normal electrocardiograms to aid in the diagnosis of myocardial infarction (MI).

Methods
Consecutive emergency department patients undergoing serial high-sensitivity cardiac troponin I (hs-cTnI) testing on clinical indication were studied in the ‘Mindray hs-cTnI Assay Analytical and Clinical Evaluation for the Diagnosis and RIsk Assessment of Myocardial InfarctIon’ (MERITnI) trial (NCT05853042). Plasma hs-cTnI testing was performed using Mindray CL1200i (investigational) and Abbott Alinity (clinical) assays.

Results
In 1,556 patients (60.7 % male, 43.3 % White, 45.8 % Black, 34.8 % chest pain), 2.7 % had type 1 MI, 2.7 % type 2 MI, and 21.5 % non-MI myocardial injury. At 0 h for all MIs (n=86), using package insert URLs and Universal Sample Bank (USB) URLs, sensitivities were 83.7 and 93.0 %. At 0/2 h for all MIs with package insert and USB URLs, sensitivities were higher with serial testing, at 95.3 and 97.7 %. Negative predictive value (NPVs) were excellent and similar for both URLs, ranging from 98 to 100 %. Substantial hs-cTnI concentration differences were observed between sex and injury types. Alinity hs-cTnI diagnostic observations were similar for both package insert and USB URLs.

Conclusions
The Mindray CL1200i hs-cTnI assay provides the relevant clinical diagnostic information to enable clinicians to deliver cost-effective care for patients to aid in the diagnosis of MI predicated on 0- and 2-h serial testing based on sex-specific 99th percentiles. Novel observations were observed for findings based on different URLs and for females and MI types.
From Cyclones to Cybersecurity: A Call for Convergence in Risk and Crisis Communications Research
Authors: Reinhold Ann Marie , Gore Ross J. , Ezell Barry , Izurieta Clemente I. , Shanahan Elizabeth A. 
Published: February 2025

Abstract
Effective risk and crisis communication can improve health and safety and reduce harmful effects of hazards and disasters. A robust body of literature investigates mechanisms for improving risk and crisis communication. While effective risk and crisis communication strategies are equally desired across different hazard types (e.g., natural hazards, cyber security), the extent to which risk and crisis communication experts utilize the “lessons learned” from scientific domains outside their own is suspect. Therefore, we hypothesized that risk and crisis communication research is siloed according to academic disciplines at the detriment to the advancement of the field of risk communications research writ large. We tested this hypothesis by evaluating the disciplinarity of 5,078 published articles containing risk and crisis communication keywords using a combination of simple descriptive statistics, natural language processing, and hierarchical clustering. Finding that the risk communication research is siloed according to disciplinary lexicons, we present our findings as a call for convergence amongst our risk and crisis communication scholars to bridge across our silos. In so doing, we will increase our ability to affect transformative change in the efficacy of our risk and crises messages across myriad hazard types – from cyclones to cybersecurity.
The RADTRAD and MicroShield analysis methodology for the LOCA during the long-term shutdown period of Chinshan BWR/4 nuclear power plant
Authors: Lin Hao-Tzu , Lee Shiau-Yu , Hsu Keng-Hsien 
Published: February 2025

Abstract
The Chinshan Nuclear Power Plant is a BWR/4 plant and is in the long-term shutdown period with the fuels still residing in the reactor core. This study presents the methodology for immersion dose analysis of loss of coolant accident (LOCA) with the above conditions and assuming some of the safety systems, facilities and radiation shielding fail. The RADTRAD and MicroShield codes are used in the methodology. This methodology can be used to calculate whole body dose, thyroid dose, and beta-skin dose received by control room personnel for the condition with full core damaged and calculate direct gamma ray radiation dose of control room personnel for the condition with no fuels damaged. The analysis results show that even failures in the safety systems, facilities or radiation shielding during the LOCA, the whole body dose, thyroid dose, and beta-skin dose are well below the acceptance limits specified in the Standard Review Plan.
Crystal structure of (E)-2-hydroxy-N′-(1-(4-hydroxyphenyl)propylidene)benzohydrazide, C16H16N2O3
Authors: Xu Xiaona , Tong Hongjuan , Liu Bin 
Published: February 2025

Abstract
C16H16N2O3, monoclinic, P21/c (no. 14), a = 8.9406(3) Å, b = 9.3999(3) Å, c = 17.1101(6) Å, β = 98.8190(10)°, V = 1420.95(8) Å3, Z = 4, Rgt
(F) = 0.0468, wRref
(F
2) = 0.1213, T = 298 K.