bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental sustainability of post-orthodontic dental retainers: a comparative life-cycle assessment of Hawley and Essix retainers
Authors: Da Tan Timothy You , Duane Brett , Hussein Ahmed , Samsonova Anna , Sizun Gwenola , Shakerdi Loujin , Taqi Roqaya , Wolfram Samuel , Ziaeefard Nazanin , Sagheri Darius 
Published: March 2024

Summary

Background
Environmental sustainability has been brought into the limelight due to the global climate crisis. This crisis is driven by human activities and even the healthcare sector is no exception. Within dentistry, orthodontics is a large global market; hence, the use of post-orthodontic retainers has a significant environmental footprint. The aim of this study was to determine the environmental sustainability of post-orthodontic retention using Hawley and Essix retainers.

Materials and methods
A comparative life-cycle assessment (LCA) was carried out to compare the environmental impact of both retainers. All inputs and outputs were accounted for using the Ecoinvent database, v3.7.1, and openLCA software. Sixteen impact categories were used to determine their environmental burden.

Results
Of the 16 impact categories, the Hawley had a greater environmental burden than the Essix retainer in 12 categories. The Hawley’s most significant contributors to its impact values are factory manufacturing and in-house production, with an average of 41.45% and 52.52%, respectively. For the Essix, the greatest contributor is factory manufacturing, with an average of 64.63%. However, when factoring in the lifespan of the retainers, the Essix would have a greater environmental impact than the Hawley retainer.

Limitations
This study employed a comparative LCA. There were also assumptions made, but these were supported by research.

Conclusions
On the basis of the evidence gathered in this study, Hawley retainers are more environmentally sustainable than Essix retainers. These results would better enable clinicians to factor in the environmental impact and make informed decisions on the choice of retainer type.
Children left behind. New evidence on the (adverse) impact of grade retention on educational careers
Authors: Contini Dalit , Salza Guido 
Published: March 2024

Abstract
This article analyzes the effect of grade retention in high school on later school outcomes in Italy. Grade retention is a strong signal of poor performance, so retained students should revise downwards their perceived probability of success in school. Grade retention also implies an increase in costs. Therefore, we expect a negative effect on future educational careers. However, the evidence from the existing literature is mixed. Using longitudinal administrative data, we propose a matching strategy to assess the impact of grade retention on institutional settings with considerable leeway in promotion/retention decisions. Following this strategy, we can interpret our results as estimates of the impact for students close to the threshold between retention and promotion. Our results add to the existing evidence that grade retention in high school has a negative impact on student’s educational outcomes by dramatically increasing dropout rates. Consistent with the compensatory advantage hypothesis, the negative effects are stronger for students with low educated or immigrant parents. Our findings suggest that alternatives to grade retention should be found to address underachievement.
Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions
Authors: Hajj-Boutros Guy , Faust Andréa , Muscedere John , Kim Perry , Abumrad Naji , Chevalier Stéphanie , Aubertin-Leheudre Mylene , Bergman Howard , Bowdish Dawn , Burford Jessica , Carrington-Lawrence Stacy , Côté Hélène , Dawe David E , Barreto Philipe de Souto , Farrelly Colin , Fowler Robert , Gouspillou Gilles , Harrington Lea , Lautrup Sofie , Howlett Susan , Imani Mahdi , Kirkland James , Kuchel George , Mallette Frédérick A , Morais José A , Newman John C , Pullman Daryl , Sierra Felipe , Van Raamsdonk Jeremy , Watt Jennifer , Rylett Rebecca Jane , Duque Gustavo 
Published: March 2024

Abstract
The inaugural Canadian Conferences on Translational Geroscience were held as 2 complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience, and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic determinants of aging, and prevention of chronic disease were addressed, the conferences went on to emphasize practical applications for enhancing older people’s quality of life. This article summarizes the proceeding and underscores the synergy between clinical and fundamental studies. Future directions highlight national and global collaborations and the crucial integration of early-career investigators. This work charts a course for a national framework for continued innovation and advancement in translational geroscience in Canada.
Data processing solutions to render metabolomics more quantitative: case studies in food and clinical metabolomics using Metabox 2.0
Authors: Wanichthanarak Kwanjeera , In-on Ammarin , Fan Sili , Fiehn Oliver , Wangwiwatsin Arporn , Khoomrung Sakda 
Published: March 2024

Abstract
In classic semiquantitative metabolomics, metabolite intensities are affected by biological factors and other unwanted variations. A systematic evaluation of the data processing methods is crucial to identify adequate processing procedures for a given experimental setup. Current comparative studies are mostly focused on peak area data but not on absolute concentrations. In this study, we evaluated data processing methods to produce outputs that were most similar to the corresponding absolute quantified data. We examined the data distribution characteristics, fold difference patterns between 2 metabolites, and sample variance. We used 2 metabolomic datasets from a retail milk study and a lupus nephritis cohort as test cases. When studying the impact of data normalization, transformation, scaling, and combinations of these methods, we found that the cross-contribution compensating multiple standard normalization (ccmn) method, followed by square root data transformation, was most appropriate for a well-controlled study such as the milk study dataset. Regarding the lupus nephritis cohort study, only ccmn normalization could slightly improve the data quality of the noisy cohort. Since the assessment accounted for the resemblance between processed data and the corresponding absolute quantified data, our results denote a helpful guideline for processing metabolomic datasets within a similar context (food and clinical metabolomics). Finally, we introduce Metabox 2.0, which enables thorough analysis of metabolomic data, including data processing, biomarker analysis, integrative analysis, and data interpretation. It was successfully used to process and analyze the data in this study. An online web version is available at http://metsysbio.com/metabox.
Good practices in designing a communication channel architecture for secure async flexible distributed collaboration
Authors: Erdei Rudolf , Delinschi Daniela , Matei Oliviu , Andreica Laura 
Published: March 2024

Abstract
In this paper we present a set of good practices in the design of a security-centric architecture for a Communication Channel that can be used to secure a Loosely-Coupled distributed platform, over unreliable communication mediums. The proposed practices are derived from designing a complete architecture that is modular and designed to support principles of Service Oriented Architecture (SOA) and the common functional requirements of a wide range of applications, including cybersecurity, smart power grids and industrial Internet of Things (IoT). The architecture was developed and implemented as part of the BIECO project, and is based around open standards such as Open Platform Communications United Architecture (OPC-UA). The key feature of the architecture is that it enables secure asynchronous near-real-time communication between a large number of nodes in a multimodal setup, without the need of any Service to know its place within the tool-chain. Based on our experience with building this system and based on the good results obtained, we are presenting a list of lessons learnt, recommendations for better communication channel modules within loosely coupled distributed systems.
The professional backstaging of diversity in journalism
Authors: Carter Ashley W , Ferrucci Patrick 
Published: March 2024

Abstract
This study examines how diverse US-based journalists—both Black, Indigenous, and people of color and lesbian, gay, bisexual, transgender, queer [or sometimes questioning] and others—perform their diversity within newsrooms. Applying Goffman’s theory of dramaturgy, the study illustrates the nuanced differences in terms of how journalists perform their diverse identities differently on both the frontstage and backstage. These differences are explained through the proliferation of historical norms such as objectivity in journalism in the United States, norms that curtail how diversity can be enacted. The study introduces the concept of professional backstaging, a concept that describes how professional norms can bypass organizational and individual agency to force certain actions off the frontstage. Finally, the discussion theorizes how these findings—and particularly the concept of professional backstaging—can contribute to future work across studies of media organizations and within the discipline of organizational communication.
Mucinous cystadenoma of the ovary with xanthogranulomatous oophoritis: the first case report in the literature
Authors: Nouh Diana , Dayoub Maisoon , Al-janabi Moatasem Hussein 
Published: March 2024

Abstract
This case report presents a unique and unprecedented occurrence of mucinous cystadenoma of the ovary accompanied by xanthogranulomatous oophoritis, a rare inflammatory condition. To the best of our knowledge, this is the first documented case of its kind in the medical literature. The patient, a 25-year-old woman, presented with abdominal pain, fever, and discomfort, prompting further investigation that led to the unexpected discovery of these coexisting pathologies.
Existential Risk, Climate Change, and Nonideal Justice
Authors: McLaughlin Alex 
Published: March 2024

Abstract
Climate change is often described as an existential risk to the human species, but this terminology has generally been avoided in the climate-justice literature in analytic philosophy. I investigate the source of this disconnect and explore the prospects for incorporating the idea of climate change as an existential risk into debates about climate justice. The concept of existential risk does not feature prominently in these discussions, I suggest, because assumptions that structure ‘ideal’ accounts of climate justice ensure that the prospect of climate change as an extinction-level threat does not arise. Given persistent noncompliance with mitigation duties, however, we have reason to revisit these assumptions. I argue that the most promising way for theories of climate justice to account for the significance of existential risk is to look to the practices of protest and resistance in which a concern about extinction or global catastrophe is frequently given expression.
Neuroscience of the yogic theory of consciousness
Authors: Tripathi Vaibhav , Bharadwaj Pallavi 
Published: March 2024

Abstract
Yoga as a practice and philosophy of life has been followed for more than 4500 years with known evidence of yogic practices in the Indus Valley Civilization. The last few decades have seen a resurgence in the utility of yoga and meditation as a practice with growing scientific evidence behind it. Significant scientific literature has been published, illustrating the benefits of yogic practices including ‘asana’, ‘pranayama’ and ‘dhyana’ on mental and physical well-being. Electrophysiological and recent functional magnetic resonance imaging (fMRI) studies have found explicit neural signatures for yogic practices. In this article, we present a review of the philosophy of yoga, based on the dualistic ‘Sankhya’ school, as applied to consciousness summarized by Patanjali in his yoga sutras followed by a discussion on the five ‘vritti’ (modulations of mind), the practice of ‘pratyahara’, ‘dharana’, ‘dhyana’, different states of ‘samadhi’, and ‘samapatti’. We formulate the yogic theory of consciousness (YTC), a cohesive theory that can model both external modulations and internal states of the mind. We propose that attention, sleep and mind wandering should be understood as unique modulatory states of the mind. YTC allows us to model the external states, internal states of meditation, ‘samadhi’ and even the disorders of consciousness. Furthermore, we list some testable neuroscientific hypotheses that could be answered using YTC and analyse the benefits, outcomes and possible limitations.
Chapter 8 Publishing History of the Essays
Authors: Balsamo Jean 
Published: March 2024

Abstract
The originality of Montaigne's literary project during his time was to have been able to combine an aristocratic and private writing style with a public publishing ambition, which is linked to the circulation of his book in the "bookseller's shop." The Essays thus are part of a long publishing history, whose stages corresponded to as many possible kinds of reading: the various editions (1580, 1582, 1588), planned out by the writer himself, the posthumous edition (1595), scrupulously put together by Marie de Gournay, along with its avatars until the nineteenth century, the debate about the Bordeaux Copy, and finally the choice of the best text on philological grounds.
Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice
Authors: Walsh Darren J , Bernard David J , Fiddler Joanna L , Pangilinan Faith , Esposito Madison , Harold Denise , Field Martha S , Parle-McDermott Anne , Brody Lawrence C 
Published: March 2024

Abstract
One-carbon metabolism is a complex network of metabolic reactions that are essential for cellular function including DNA synthesis. Vitamin B12 and folate are micronutrients that are utilized in this pathway and their deficiency can result in the perturbation of one-carbon metabolism and subsequent perturbations in DNA replication and repair. This effect has been well characterized in nuclear DNA but to date, mitochondrial DNA (mtDNA) has not been investigated extensively. Mitochondrial variants have been associated with several inherited and age-related disease states; therefore, the study of factors that impact heteroplasmy are important for advancing our understanding of the mitochondrial genome's impact on human health. Heteroplasmy studies require robust and efficient mitochondrial DNA enrichment to carry out in-depth mtDNA sequencing. Many of the current methods for mtDNA enrichment can introduce biases and false-positive results. Here, we use a method that overcomes these limitations and have applied it to assess mitochondrial heteroplasmy in mouse models of altered one-carbon metabolism. Vitamin B12 deficiency was found to cause increased levels of mitochondrial DNA heteroplasmy across all tissues that were investigated. Folic acid supplementation also contributed to elevated mitochondrial DNA heteroplasmy across all mouse tissues investigated. Heteroplasmy analysis of human data from the Framingham Heart Study suggested a potential sex-specific effect of folate and vitamin B12 status on mitochondrial heteroplasmy. This is a novel relationship that may have broader consequences for our understanding of one-carbon metabolism, mitochondrial-related disease and the influence of nutrients on DNA mutation rates.
Review Essay: Donald Trump, Charismatic Leadership and the “Deep State”
Authors: Milkis Sidney M 
Published: March 2024

Abstract
There have been many accounts of Donald Trump's assault on America's constitutional norms and institutions. Journalists have detailed how a real estate mogul and reality television star with no experience in public office captured the Republican Party and disrupted the regular protocols of the executive branch. Legal scholars have lamented Trump's politicization of the Justice Department breaking through the fragile guard rails put in place in the wake of the Watergate scandal. Psychiatrists have sought to diagnose Trump's politics of resentment, which they attribute to the rage and narcissism of a sociopath. Amid this frenzy John Campbell's Institutions Under Siege: Donald Trump's Attack on the Deep State provides a comprehensive study on Trump's assault on American political and government institutions. He shows persuasively that Trump's presidency had a deep and dangerous imprint on elections, the Republican Party, the bureaucracy, and fiscal policy. Critically examining Campbell’s theory and evidence, this essay considers where Trump stands in the long train of democratic crises that have occurred throughout American history, how his presidency and its provocative aftermath were a symptom of long-standing changes in the relationship between the presidency and the party system, and why the presidency itself might be a polarizing institution.
The Effect of the 2020 Black Lives Matter Protests on Police Budgets: How “Defund the Police” Sparked Political Backlash
Authors: Ebbinghaus Mathis , Bailey Nathan , Rubel Jacob 
Published: March 2024

Abstract
This article investigates whether a core political demand of the 2020 Black Lives Matter (BLM) protests was realized: “defund the police.” Original hand-compiled data containing budget information on 264 major cities in the United States and comprehensive protest data enable us to assess the effect of protests on changes in city police budgets. We find no evidence that BLM protests led to police defunding. In cities with large Republican vote shares, protest is associated with significant increases in police budgets. We demonstrate that electoral incentives cannot explain this policy backlash. Instead, we provide tentative evidence that backlash in Republican cities might stem from policymakers’ own conservatism and entrenched right-wing influences within city politics. The analysis offers novel evidence on the consequences of the largest protest movement in U.S. history and reveals the importance of backlash in explaining policy outcomes of social movements.
Combined Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Surgery of the Foot or Ankle: A Randomized, Blinded, Placebo-controlled Clinical Trial
Authors: Maagaard Mathias , Funder Kamilia S. , Schou Nikolaj K. , Penny Jeannette Ø. , Toquer Peter , Laigaard Jens , Stormholt Emma R. , Nørskov Anders K. , Jæger Pia , Andersen Jakob H. , Mathiesen Ole 
Published: March 2024

Background
Both dexamethasone and dexmedetomidine increase the duration of analgesia of peripheral nerve blocks. The authors hypothesized that combined intravenous dexamethasone and intravenous dexmedetomidine would result in a greater duration of analgesia when compared with intravenous dexamethasone alone and placebo.

Methods
The authors randomly allocated participants undergoing surgery of the foot or ankle under general anesthesia and with a combined popliteal (sciatic) and saphenous nerve block to a combination of 12 mg dexamethasone and 1 µg/kg dexmedetomidine, 12 mg dexamethasone, or placebo (saline). The primary outcome was the duration of analgesia measured as the time from block performance until the first sensation of pain in the surgical area as reported by the participant. The authors predefined a 33% difference in the duration of analgesia as clinically relevant.

Results
A total of 120 participants from two centers were randomized and 119 analyzed for the primary outcome. The median [interquartile range] duration of analgesia was 1,572 min [1,259 to 1,715] with combined dexamethasone and dexmedetomidine, 1,400 min [1,133 to 1,750] with dexamethasone alone, and 870 min [748 to 1,138] with placebo. Compared with placebo, the duration was greater with combined dexamethasone and dexmedetomidine (difference, 564 min; 98.33% CI, 301 to 794; P < 0.001) and with dexamethasone (difference, 489 min; 98.33% CI, 265 to 706; P < 0.001). The prolongations exceeded the authors’ predefined clinically relevant difference. The duration was similar when combined dexamethasone and dexmedetomidine was compared with dexamethasone alone (difference, 61 min; 98.33% CI, –222 to 331; P = 0.614).

Conclusions
Dexamethasone with or without dexmedetomidine increased the duration of analgesia in patients undergoing surgery of the foot or ankle with a popliteal (sciatic) and saphenous nerve block. Combined dexamethasone and dexmedetomidine did not increase the duration of analgesia when compared with dexamethasone.

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Implications of Cardiac Scarring on Body Image Disturbance Among Young Adults With Congenital Heart Defects
Authors: Grant Victoria R. , Crerand Canice E. , Jackson Jamie L. 
Published: March 2024

Background
Many individuals with congenital heart disease (CHD) undergo open heart surgery, resulting in prominent scarring. However, little research has assessed the impact of surgical scarring on body image in this population.

Objective
Within this cross-sectional study, associations between body image concerns, anxiety and depression symptoms, and health-related quality of life among individuals with CHD were evaluated.

Methods
Young adults with CHD (N = 138) completed the Body Image Disturbance Questionnaire along with other patient-reported outcome measures.

Results
Scores on the Body Image Disturbance Questionnaire were lower (mean, 1.3 ± 0.5) than populations with diabetes amputations, craniofacial conditions, idiopathic scoliosis, and clinical controls. Higher Body Image Disturbance Questionnaire scores were reported among women (P = .003) and were associated with greater anxiety (P = .000) and depression (P = .13) after controlling for sex.

Conclusions
Body image concerns related to cardiac surgery scarring are especially prominent in women and associated with greater emotional distress, suggesting potential clinical relevance for evaluating body image concerns in persons with CHD.