bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders
Authors: Rozovsky Renata , Bertocci Michele , Iyengar Satish , Stiffler Richelle S. , Bebko Genna , Skeba Alexander S. , Brady Tyler , Aslam Haris , Phillips Mary L. 
Published: April 2024

AbstractThe number of young adults seeking help for emotional distress, subsyndromal-syndromal mood/anxiety symptoms, including those associated with neuroticism, is rising and can be an early manifestation of mood/anxiety disorders. Identification of gray matter (GM) thickness alterations and their relationship with neuroticism and mood/anxiety symptoms can aid in earlier diagnosis and prevention of risk for future mood and anxiety disorders. In a transdiagnostic sample of young adults (n = 252;177 females; age 21.7 ± 2), Hypothesis (H) 1:regularized regression followed by multiple regression examined relationships among GM cortical thickness and clinician-rated depression, anxiety, and mania/hypomania; H2:the neuroticism factor and its subfactors as measured by NEO Personality Inventory (NEO-PI-R) were tested as mediators. Analyses revealed positive relationships between left parsopercularis thickness and depression (B = 4.87,p = 0.002), anxiety (B = 4.68,p = 0.002), mania/hypomania (B = 6.08,p ≤ 0.001); negative relationships between left inferior temporal gyrus (ITG) thickness and depression (B = − 5.64,p ≤ 0.001), anxiety (B = − 6.77,p ≤ 0.001), mania/hypomania (B = − 6.47,p ≤ 0.001); and positive relationships between left isthmus cingulate thickness (B = 2.84,p = 0.011), and anxiety. NEO anger/hostility mediated the relationship between left ITG thickness and mania/hypomania; NEO vulnerability mediated the relationship between left ITG thickness and depression. Examining the interrelationships among cortical thickness, neuroticism and mood and anxiety symptoms enriches the potential for identifying markers conferring risk for mood and anxiety disorders and can provide targets for personalized intervention strategies for these disorders.
Bidirectional mediation of bone mineral density and brain atrophy on their associations with gait variability
Authors: Zhang Xin , Lu Heyang , Fan Min , Tian Weizhong , Wang Yingzhe , Cui Mei , Jiang Yanfeng , Suo Chen , Zhang Tiejun , Jin Li , Xu Kelin , Chen Xingdong 
Published: April 2024

AbstractThis mediation analysis aimed to investigate the associations among areal bone mineral density, mobility-related brain atrophy, and specific gait patterns. A total of 595 participants from the Taizhou Imaging Study, who underwent both gait and bone mineral density measurements, were included in this cross-sectional analysis. We used a wearable gait tracking device to collect quantitative gait parameters and then summarized them into independent gait domains with factor analysis. Bone mineral density was measured in the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. Magnetic resonance images were obtained on a 3.0-Tesla scanner, and the volumes of brain regions related to mobility were computed using FreeSurfer. Lower bone mineral density was found to be associated with higher gait variability, especially at the site of the lumbar spine (β = 0.174, FDR = 0.001). Besides, higher gait variability was correlated with mobility-related brain atrophy, like the primary motor cortex (β = 0.147, FDR = 0.006), sensorimotor cortex (β = 0.153, FDR = 0.006), and entorhinal cortex (β = 0.106, FDR = 0.043). Bidirectional mediation analysis revealed that regional brain atrophy contributed to higher gait variability through the low lumbar spine bone mineral density (for the primary motor cortex,P = 0.018; for the sensorimotor cortex,P = 0.010) and the low lumbar spine bone mineral density contributed to higher gait variability through the primary motor and sensorimotor cortices (P = 0.026 and 0.010, respectively).
Ecological risk assessment and spatial–temporal differentiation of soil and water resources in the Hefei metropolitan area
Authors: Zhao Shuhang , He Gang , Li Jie , Yang Xia , Hou Xiaoyu , Wu Ting , Zhang Shangyun 
Published: April 2024

AbstractThere are important ways to solve the ecological risk problems of regional water resources and soil resources, and to promote the benign development of soil and water resources, involving scientific evaluation of the ecological risk of soil and water resources in Hefei metropolitan area, clarifying the intrinsic evolution law of ecological risk and identifying the characteristics of spatial and temporal variations. Based on the conceptual model of “ST-QS-RR”, the evaluation indicator system is constructed, the CRITIC method is used to assign weights, and the TOPSIS method, kernel density method, markov chain and resistance model are used to measure and analyse the spatial and temporal characteristics of ecological risk of soil and water resources, and to explore the main factors that cause ecological risk of soil and water resources. The results of the study show that: (1) Hefei metropolitan area and its cities show a steady decline and the characteristics of “high in the north and low in the south, high in the west and low in the east”. (2) Most of the subsystems in the Hefei metropolitan area and the cities show a decreasing trend, with its resistance factors mainly concentrated in the QS system. (3) There is club convergence in Hefei metropolitan area. When the type of adjacent domain is higher, the change of risk type is more sensitive.
Molecular Profiling of High-Grade B-Cell Non-Hodgkin Lymphomas and Its Clinicopathologic Correlation in an Indian Tertiary Cancer Care Center
Authors: Sebastian Nikhil , P. N Shoaib Nawaz , Ananthkrishnan Ramya , Kumanan J. , Chandran Chitra , Raja Thirumalairaj 
Published: April 2024

Abstract
Introduction Double-expressor and double-hit lymphomas (DHL) are known to be more aggressive and have poor outcomes with standard chemotherapy regimens.
Objectives To assess the incidence of DHL and triple-hit lymphomas (THL) and correlate them with clinicopathologic parameters.
Materials and Methods Patients who were diagnosed with high-grade lymphomas from April 2021 to September 2022 were prospectively followed up, and details comprising clinical and pathological parameters, including the immunohistochemistry expression status and gene rearrangements of MYC, BCL2, and BCL6, were recorded.
Results The incidence of DHL and THL in our study was 16.43%. The separate incidence of the DHL-BCL2, DHL-BCL6, and THL groups was 16.43, 13.69, and 2.73%, respectively. The germinal center B cell subtype of histology was predominantly seen in DHLs. MYC, BCL2, and BCL6 expressions do not correlate well with translocations of these genes.
Conclusion Double protein expression cannot be used for screening to decide which patients should undergo fluorescence in situ hybridization, as this would result in missing 4.5% of DHLs.
Highly compressible wearable sensor with CNT-coated PDMS sponge electrodes for tactile monitoring application
Authors: Lee Sung-Jun , Ung Shuh Chien , Kim Chang-Lae 
Published: April 2024

Abstract
Electrical resistance-based sensors have attracted great attention due to their wide range of applications, among which sensors for detecting external forces are indispensable due to the complex environment of the modern era. Inspired by the capillary phenomenon, in this study, we fabricated a carbon nanotube (CNT)-polydimethylsiloxane (PDMS)-based compressive resistive sensor that is easy to fabricate and has a wide range of sensitivities. Repeated compression tests were performed to evaluate the durability of the fabricated sensors. Different coating conditions resulted in different durability depending on the extent to which the CNT electrodes were coated on the porous PDMS surface, and the sensitivity of the sensors could be controlled by CNT concentration, coating time, and coating depth. Resistive sensors with different sensitivities can easily detect changes in electrical signals due to finger pressure, which shows great promise for use in wearable electronics. In addition, the resistive sensor is biocompatible because only the pure PDMS surface is attached to the human body, and the porous structure exhibits good compressibility.
Beam test results of the orbit correction at the low-energy superconducting accelerator section in the RAON accelerator
Authors: Jin Hyunchang , Jang Ji-Ho , Jeon Dong-O. 
Published: April 2024

Abstract
The RAON accelerator has been constructed for various
science programs with stable ions and rare isotopes since
2011. After the installation of the injector section was completed
in 2020, the low-energy superconducting accelerator (SCL3) section
was also installed consecutively until 2022, and the beam
commissioning using an argon beam is in progress from the injector
section to the SCL3 section. For successful beam commissioning,
various beam dynamics studies have been carried out, and the
research of the orbit correction has been also conducted to
determine the location and the number of steering magnets and BPMs
for safe and efficient beam operation. In the SCL3 section, the
orbit correction simulation was carried out as varying the number of
steering magnets for the consideration of the correction of
distorted beam orbit and the economic benefits, and then the beam
test was carried out based on the simulation results during the beam
commissioning. Here we will present the results of simulations and
experiments for the orbit correction at the SCL3 section in the RAON
accelerator.
scINRB: single-cell gene expression imputation with network regularization and bulk RNA-seq data
Authors: Kang Yue , Zhang Hongyu , Guan Jinting 
Published: April 2024

AbstractSingle-cell RNA sequencing (scRNA-seq) facilitates the study of cell type heterogeneity and the construction of cell atlas. However, due to its limitations, many genes may be detected to have zero expressions, i.e. dropout events, leading to bias in downstream analyses and hindering the identification and characterization of cell types and cell functions. Although many imputation methods have been developed, their performances are generally lower than expected across different kinds and dimensions of data and application scenarios. Therefore, developing an accurate and robust single-cell gene expression data imputation method is still essential. Considering to maintain the original cell–cell and gene–gene correlations and leverage bulk RNA sequencing (bulk RNA-seq) data information, we propose scINRB, a single-cell gene expression imputation method with network regularization and bulk RNA-seq data. scINRB adopts network-regularized non-negative matrix factorization to ensure that the imputed data maintains the cell–cell and gene–gene similarities and also approaches the gene average expression calculated from bulk RNA-seq data. To evaluate the performance, we test scINRB on simulated and experimental datasets and compare it with other commonly used imputation methods. The results show that scINRB recovers gene expression accurately even in the case of high dropout rates and dimensions, preserves cell–cell and gene–gene similarities and improves various downstream analyses including visualization, clustering and trajectory inference.
Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
Authors: Riemersma Iris W , Ike Kevin G O , Sollie Thomas , Meijer Elroy L , Havekes Robbert , Kas Martien J H 
Published: April 2024

Abstract
Sensory differences are a core feature of autism spectrum disorders (ASD) and are predictive of other ASD core symptoms such as social difficulties. However, the neurobiological substrate underlying the functional relationship between sensory and social functioning is poorly understood. Here, we examined whether misregulation of structural plasticity in the somatosensory cortex modulates aberrant social functioning in BTBR mice, a mouse model for autism spectrum disorder–like phenotypes. By locally expressing a dominant-negative form of Cofilin (CofilinS3D; a key regulator of synaptic structure) in the somatosensory cortex, we tested whether somatosensory suppression of Cofilin activity alters social functioning in BTBR mice. Somatosensory Cofilin suppression altered social contact and nest-hide behavior of BTBR mice in a social colony, assessed for seven consecutive days. Subsequent behavioral testing revealed that altered social functioning is related to altered tactile sensory perception; CofilinS3D-treated BTBR mice showed a time-dependent difference in the sensory bedding preference task. These findings show that Cofilin suppression in the somatosensory cortex alters social functioning in BTBR mice and that this is associated with tactile sensory processing, a critical indicator of somatosensory functioning.
Telomere-to-telomere genome assembly ofOldenlandia diffusa
Authors: Gao Yubang , Xu DanDan , Hu Zehua 
Published: April 2024

AbstractWe report the complete telomere-to-telomere genome assembly of Oldenlandia diffusa which renowned in traditional Chinese medicine, comprising 16 chromosomes and spanning 499.7 Mb. The assembly showcases 28 telomeres and minimal gaps, with a total of only five. Repeat sequences constitute 46.41% of the genome, and 49,701 potential protein-coding genes have been predicted. Compared with O. corymbosa, O. diffusa exhibits chromosome duplication and fusion events, diverging 20.34 million years ago. Additionally, a total of 11 clusters of terpene synthase have been identified. The comprehensive genome sequence, gene catalog, and terpene synthase clusters of O. diffusa detailed in this study will significantly contribute to advancing research in this species’ genetic, genomic, and pharmacological aspects.
Almost feedback linearizable systems of the class C1 and solving the constructive controllability problem
Authors: Korobov Valery I , Sklyar Katerina V , Ignatovich Svetlana Y 
Published: April 2024

Abstract
We propose a method of solving the controllability problem using almost linearizable control systems. Developing an idea of triangular systems, proposed by the first author of this paper in 1973, we introduce a wider class of almost triangular systems for which it is possible to find explicitly a control steering the system from one given point to another given point. We give conditions of almost linearizability for nonlinear single-input systems of the class $C^{1}$ and discuss a method of solving the controllability problem for such systems.
A systematic evaluation of the influence of macrophage phenotype descriptions on inflammatory dynamics
Authors: Almansour Suliman , Dunster Joanne L , Crofts Jonathan J , Nelson Martin R 
Published: April 2024

Abstract
Macrophages play a wide range of roles in resolving the inflammatory damage that underlies many medical conditions and have the ability to adopt different phenotypes in response to different environmental stimuli. Categorising macrophage phenotypes exactly is a difficult task, and there is disparity in the literature around the optimal nomenclature to describe these phenotypes; however, what is clear is that macrophages can exhibit both pro- and anti-inflammatory behaviours dependent upon their phenotype, rendering mathematical models of the inflammatory response potentially sensitive to their description of the macrophage populations that they incorporate. Many previous models of inflammation include a single macrophage population with both pro- and anti-inflammatory functions. Here, we build upon these existing models to include explicit descriptions of distinct macrophage phenotypes and examine the extent to which this influences the inflammatory dynamics that the models emit. We analyse our models via numerical simulation in MATLAB and dynamical systems analysis in XPPAUT, and show that models that account for distinct macrophage phenotypes separately can offer more realistic steady state solutions than precursor models do (better capturing the anti-inflammatory activity of tissue resident macrophages), as well as oscillatory dynamics not previously observed. Finally, we reflect on the conclusions of our analysis in the context of the ongoing hunt for potential new therapies for inflammatory conditions, highlighting manipulation of macrophage polarisation states as a potential therapeutic target.
Hematological Trends in Severe Burn Patients: A Comprehensive Study for Prognosis and Clinical Insights
Authors: Khan Amber Yousuf , Waheed Faiza , Rehan Muhammad , Arshad Zunera , Iqbal Tariq , Waqar Saman , Waheed Usman 
Published: April 2024

Abstract
Severe burn injuries pose diagnostic challenges, contributing to increased fatality rates with delayed diagnoses. This study aims to identify early risk factors and understand their impact on clinical outcomes by examining hematological dynamics in severe burn cases. The focus includes age-related patterns, total body surface area (TBSA) affected by burns, hospital stay duration, and changes in hematological markers during burn injuries. An analytical cross-sectional study at the burn care center involved 135 participants hospitalized between January 2018 and December 2021. Demographic data and hematological markers were recorded, and statistical analysis was performed using IBM SPSS 25.0. Nonsurvivors exhibited a greater mean TBSA, shorter hospital stay, and an enhanced early immune response indicated by white blood cell count on the first day. Hematological markers, including hemoglobin, red cell count (RCC), and platelet count, showed dynamic patterns over the study period. Marginal variations in platelet counts and intriguing patterns in RCC suggested potential consequences like disseminated intravascular coagulation. The study provides crucial insights into hematological responses to severe burn injuries. Early identification of risk factors, particularly age-related patterns and immune responses, informs clinicians about predicting outcomes and guiding therapeutic interventions. Despite limitations, this work underscores the need for further multicenter research to comprehensively understand the complex relationships between burn injuries, hematological responses, and clinical outcomes.
Trends and regional distribution in health-related quality of life across sex and employment status: a repeated population-based cross-sectional study
Authors: Ahn Soon-Ki , Seo Hyun-Ju , Choi Min-Jung 
Published: April 2024

Abstract

Objectives:
This study investigated the association between sex and health-related quality of life (HRQoL) based on employment status.

Methods:
This was a population-based cross-sectional study. Data were collected from 1 996 153 adults aged ≥19 years who participated in the Korea Community Health Survey from 2011 to 2019. Low HRQoL was classified based on separate cutoff points (males: 0.92, females: 0.90) on the European Quality of Life-5 Dimensions index. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) and 95% CIs.

Results:
From 2011 to 2019, the trend of the prevalence of low HRQoL levels was consistently high in the order of unemployed males, unemployed females, employed males, and employed females. Regarding the regional distribution of unemployed males, the prevalence of low HRQoL was 29.5% to 43.5%. Unemployed males had a higher prevalence of low HRQoL (OR: 1.15; 95% CI: 1.12-1.24) than employed males.

Conclusions:
This study suggests that the prevalence of low HRQoL levels among unemployed males was consistently high at the annual trend and regional levels. Further research considering comprehensive health determinants and multidimensional public health interventions is required to prevent deterioration of HRQoL during unemployment.
Trends and distribution of external radiation therapy facilities in Japan based on Survey of Medical Institutions from the Ministry of Health, Labour and Welfare
Authors: Aoyama Takahiro , Koide Yutaro , Shimizu Hidetoshi , Kitagawa Tomoki , Iwata Tohru , Hashimoto Shingo , Tachibana Hiroyuki , Kodaira Takeshi 
Published: April 2024

Abstract
This study aimed to explore the distribution of external radiation therapy (RT) facilities, the status of related device installations and the adoption of high-precision RT using Survey of Medical Institutions from the Ministry of Health, Labour and Welfare in Japan. Analysis, categorized by the hospital size and prefecture, provides specific insights into the trends in treatment facility healthcare capabilities. Data on the number of RT facilities, high-precision RT facilities, RT devices and treatment planning systems (TPS) categorized by the number of beds and prefecture from 1996 to 2020 were analyzed. In addition, the study examined the correlation between the high-precision implementation rate and the number of TPSs or radiation oncologists and other medical staff. High-precision RT exceeded 95% in large facilities (800+ beds) but remained &lt;50% in medium-sized facilities (300–499 beds). In a prefecture-by-prefecture analysis, calculation of the maximum–minimum ratio of RT facilities per million population and per 30 km2 revealed a disparity of 3.7 and 73.1 times in the population ratio and the density ratio, respectively. Although a correlation was found between the number of TPSs per RT device or the number of medical physicists per million population and the rate of high-precision RT implementation, no correlation was found among other professions. Detailed analysis based on the hospital size and prefecture provided more specific information on the medical functions of RT facilities in Japan. These findings can potentially contribute to the future development of RT, including the standardization of treatment techniques and optimal resource allocation.
What may an adrenal mass conceal? Adrenal gastrointestinal stromal tumor: a case report
Authors: Alafifi Mahmoud , Doumer Abderrahmane , Abdi El Mostaoha , Safieddine Mehdi , Moataz Amine , Dakir Mohamed , Debbagh Adil , Aboutaieb Rachid 
Published: April 2024

Abstract
Extraintestinal gastrointestinal stromal tumors (GISTs) are extremely rare, and adrenal GISTs are even exceptional. Only three cases have been reported in the literature thus far, the current case being the fourth. This case demonstrates the need of including extraintestinal GIST in the differential diagnosis when investigating adrenal tumors. Herein, we present a case of adrenal GIST diagnosed in a 60-year-old female patient who had a left adrenal GIST surgically removed as an adrenal tumor.
Environment, Slavery and Agency in Colonial Uruguay, 1750–1810
Authors: Travieso Emiliano 
Published: April 2024

Abstract
In colonial Uruguay black slaves could supervise the work of white creoles and even hold the power to have their wages docked. To most historians this might seem puzzling and almost fictional in the context of the colonial Americas. This article makes sense of the puzzle by examining interactions between the economy and the environment on the Río de la Plata frontier. It argues that the natural world (soils, topography, climate, crops and animals) contributes to explain why this labour system existed, and also why it was efficient, contrary to the historiographical commonplace that enslaved workers would be unable to oversee free labourers effectively. Looking at the experience of both women and men through the lens of gender uncovers the parallels between the authority of these enslaved foremen over free male workers on the open range and their domestic authority over free women, whom they could marry. Their stories invite historians of other places and periods to foreground the environment in the set of structures that can either limit workers’ autonomy or give them strength.