bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shifting paradigms: a pivotal study on laparoscopic resection for colovesical fistulas in diverticular disease
Authors: Rizzuto Antonia , Andreuccetti Jacopo , Bracale Umberto , Silvestri Vania , Pontecorvi Emanuele , Reggio Stefano , Sagnelli Carlo , Peltrini Roberto , Amaddeo Angela , Bozzarello Cristina , Pignata Giusto , Cuccurullo Diego , Corcione Francesco 
Published: March 2024

BackgroundColovesical fistulas (CVFs) pose a challenge in diverticulitis, affecting 4% to 20% of sigmoid colon cases. Complicated diverticular disease contributes significantly, accounting for 60%−70% of all CVFs. Existing studies on laparoscopic CVF management lack clarity on its effectiveness in diverticular cases compared to open surgery. This study redefines paradigms by assessing the potentiality, adequacy, and utility of laparoscopy in treating CVFs due to complicated diverticular disease, marking a paradigm shift in surgical approaches.MethodsConducting a retrospective analysis at Ospedale Monaldi A.O.R.N dei Colli and University Federico II, Naples, Italy, patients undergoing surgery for CVF secondary to diverticular disease between 2010 and 2020 were examined. Comprehensive data, including demographics, clinical parameters, preoperative diagnoses, operative and postoperative details, and histopathological examination, were meticulously recorded. Patients were classified into open surgery (Group A) and laparoscopy (Group B). Statistical analysis used IBM SPSS Statistic 19.0.ResultsFrom January 2010 to December 2020, 76 patients underwent surgery for colovesical fistula secondary to diverticular disease. Laparoscopic surgery (Group B, n = 40) and open surgery (Group A, n = 36) showed no statistically significant differences in operative time, bladder suture, or associated procedures. Laparoscopy demonstrated advantages, including lower intraoperative blood loss, reduced postoperative primary ileus, and a significantly shorter length of stay. Postoperative morbidity differed significantly between groups. Mortality occurred in Group A but was unrelated to surgical complications. No reoperations were observed. Two-year follow-up revealed no fistula recurrence.ConclusionThis pivotal study marks a paradigm shift by emphasizing laparoscopic resection and primary anastomosis as a safe and feasible option for managing CVF secondary to diverticular disease. Comparable conversion, morbidity, and mortality rates to the open approach underscore the transformative potential of these findings. The study's emphasis on patient selection and surgeon experience challenges existing paradigms, offering a progressive shift toward minimally invasive solutions.
Cecropin A: investigation of a host defense peptide with multifaceted immunomodulatory activity in a chicken hepatic cell culture
Authors: Márton Rege Anna , Sebők Csilla , Mackei Máté , Tráj Patrik , Vörösházi Júlia , Kemény Ágnes , Neogrády Zsuzsanna , Mátis Gábor 
Published: March 2024

IntroductionHost defense peptides (HDPs) are increasingly referred to as promising candidates for the reduction of the use of conventional antibiotics, thereby combating antibiotic resistance. As HDPs have been described to exert various immunomodulatory effects, cecropin A (CecA) appears to be a potent agent to influence the host inflammatory response.MethodsIn the present study, a chicken primary hepatocyte–non-parenchymal cell co-culture was used to investigate the putative immunomodulatory effects of CecA alone and in inflammatory conditions evoked by polyinosinic-polycytidylic acid (Poly I:C). To examine the viability of the cells, the extracellular lactate dehydrogenase (LDH) activity was determined by colorimetric assay. Inflammatory markers interleukin (IL)-8 and transforming growth factor-ß1 (TGF-ß1) were investigated using the ELISA method, whereas concentrations of IL-6, IL-10, and interferon-γ (IFN-γ) were assayed by Luminex xMAP technology. Extracellular H2O2 and malondialdehyde levels were measured by fluorometric and colorimetric methods, respectively.ResultsResults of the lower concentrations suggested the safe application of CecA; however, it might contribute to hepatic cell membrane damage at its higher concentrations. We also found that the peptide alleviated the inflammatory response, reflected by the decreased production of the pro-inflammatory IL-6, IL-8, and IFN-γ. In addition, CecA diminished the levels of anti-inflammatory IL-10 and TGF-ß1. The oxidative markers measured remained unchanged in most cases of CecA exposure.DiscussionCecA displayed a multifaceted immunomodulatory but not purely anti-inflammatory activity on the hepatic cells, and might be suggested to maintain the hepatic inflammatory homeostasis in Poly I:C-triggered immune response. To conclude, our study suggests that CecA might be a promising molecule for the development of new immunomodulatory antibiotic-substitutive agents in poultry medicine; however, there is still a lot to clarify regarding its cellular effects.
Implementasi Model Waterfall pada Sistem E-Internship PT Petikemas Surabaya
Authors: Rahayu Setyaningrum Putri , Rakhma Devi Putri Aisyiyah 
Published: March 2024

Abstrak

Pada era modern seperti saat ini teknologi dan komunikasi sangat dibutuhkan oleh setiap perusahaan ataupun instansi seperti di PT Terminal Petikemas Surabaya (PT TPS) bagian Dept. SDM PT TPS membutuhkan sebuah sistem untuk mengatasi kendala berupa banyaknya permintaan pemagang yang masuk. Karena kapasitas untuk setiap departemen yang dituju sesuai prodi mahasiswa terbatas menyebabkan overload. Sistem yang dimaksud yaitu Sistem Informasi Magang Online. Dalam pembuatan sistem tersebut dibutuhkan sebuat metode waterfall untuk membantu saat proses perancangan. Metode Waterfall memiliki proses tahapan yang berurutan dan sistematis mempermudah pengerjaan dalam pembuatan sistem. Berdasarkan hasil analisis dan implementasi metode waterfall yang dilakukan pada Sistem Informasi Magang Online dapat diambil kesimpulan bahwa dengan adanya Sistem Informasi Magang Online bisa mempermudah Peserta Magang, Departemen SDM PT TPS dan Kepala Departemen PT TPS dalam melakukan persetujuan Magang serta dapat memonitoring kuota magang di setiap departemen.

Keywords – Sistem, Magang, Metode Waterfall

Abstrak

In the modern era like today, technology and communication are needed by every company or agency, such as at PT Terminal Petikemas Surabaya (PT TPS) part of the Dept. PT TPS HR requires a system to overcome obstacles in the form of many incoming intern requests. Because the capacity for each department that is targeted according to the student study program is limited, causing overload. The system in question is the Online Apprentice Information System. In making the system, a waterfall method is needed to help during the design process. The Waterfall method has a sequential and systematic process of stages making it easier to work on the system. Based on the results of the analysis and implementation of the waterfall method on the Online Apprentice Information System, it can be concluded that the Online Apprentice Information System can make it easier for Apprentices, the HR Department of PT TPS and the Head of the Department of PT TPS to approve Apprenticeships and can monitor internship quotas in each department. .
Keywords – System, Apprentice, Waterfall Method
Temu Bahaya & Pencemaran (TEBARAN) Berbasis Aplikasi Android Pada Sistem Sumbang Saran di PTNUSIRA,Untuk Mencegah Terjadinya Kecelakaan Kerja, Pencemaran Lingkungan Di Lingkungan Kerja
Authors: Ridwan Achmad 
Published: March 2024

Mencegah terjadi kecelakaan kerja atau pencemaran lingkungan pada lingkungan kerja disuatu perusahaan salah satu caranya dengan menemukan dan melaporkan dengan cepat dan detail temuan 5R, tindakan berbahaya, kondisi berbahaya dan pencemaran dilingkungan kerja tersebut. Temuan 5R, tindakan berbahaya, kondisi berbahaya dan pencemaran tersebut dengan cara melibatkan seluruh karyawan yang bekerja pada suatu perusahaan. Jika karyawan menemukan temuan 5R, tindakan berbahaya, kondisi berbahaya dan pencemaran membuat laporan temuan tersebut sehingga dapat ditindaklanjutin dengan melakukan tindakan pencegahan atau perbaikan agar tidak terjadinya kecelakaan kerja atau pencemaran dilingkungan kerja perusahaan. Selama ini karyawan menyampaikan temuan tersebut dengan cara menuliskan atau memprint temuan tersebut pada form laporan temuan dan lampirkan foto temuan, sehingga berdampak kepada karyawan malas atau ogah untuk menyampaikan temuan tersebut. Untuk mengantisipasi masalah ini maka dibuatkanlah sebuah aplikasi Temu Bahaya dan Pencemaran (TEBARAN) yang berbasiskan android. Menggunakan sistem android ini dikarenakan mempermudah karyawan membuat laporan jika menemukan temuan 5R, tindakan berbahaya, kondisi berbahaya dan pencemaran yang dapat menyebabkan terjadinya kecelakaan kerja atau pencemaran lingkungan. Metode yang digunakan dalam penelitian ini adalah wawancara dan praktek yang terkait pembuatan aplikasi tebaran yang berbasiskan android. Model yang digunakan dalam pembuatan aplikasi ini adalah model waterfall. Model ini digunakan karena pendekatan aplikasi secara berurut sehingga menghasilkan aplikasi yang sesuai dengan penerapan di PT Nusira. Berdasarkan hasil pengujian aplikasi tebaran berjalan baik sesuai yang diharapkan, sehingga dapat melibatkan seluruh karyawan serta dapat membuat laporan temuan dengan cepat untuk dapat ditindaklanjutin. Berdasarkan penelitian ini dapat diambil kesimpulan yaitu aplikasi tebaran berjalan baik sesuai target yang diharapkan serta aplikasi tebaran ini dapat digunakan pada perusahaan lain.
Improvement of Charcot-Marie-Tooth Phenotype with a Nanocomplex Treatment in Two Transgenic Models of CMT1A
Authors: El Massry Mohamed , Msheik Zeina , El Masri Tarek , Ntoutoume Gautier MA Ndong , Vignaud Laetitia , Richard Laurence , Pinault Emilie , Faye Pierre-Antoine , Bregier Frédérique , Marquet Pierre , Favreau Frédéric , Vallat Jean-Michel , Billet Fabrice , Sol Vincent , Sturtz Franck , Desmouliere Alexis 
Published: March 2024

Curcumin has been shown to exert beneficial effects in peripheral neuropathies. Despite its known biological activities, curcumin has unfavorable pharmacokinetics. Its instability has been linked to its failure in clinical trials of curcumin for the treatment of human pathologies. For this reason, we developed curcumin-loaded cyclodextrin/cellulose nanocrystals (NanoCur) to improve its pharmacokinetics. The present study aims to assess the potency of a low dose of NanoCur in 2 Charcot-Marie-Tooth disease type 1A (CMT1A) rodent models at different stages of the disease. The efficiency of NanoCur is also compared to that of Theracurmin (Thera), a commercially available curcumin formulation. The toxicity of a short-term and chronic exposure to the treatment is investigated both in vitro and in vivo, respectively. Furthermore, the entry route, the mechanism of action and the effect on the nerve phenotype are dissected in this study. Overall, the data support an improvement in sensorimotor functions, associated with amelioration in peripheral myelination in NanoCur-treated animals; an effect that was not evident in the Thera-treated group. That was combined with a high margin of safety both in vivo and in vitro. Furthermore, NanoCur appears to inhibit inflammatory pathways that normally include macrophage recruitment to the diseased nerve. This study shows that NanoCur shows therapeutic benefits with minimal systemic toxicity, suggesting that it is a potential therapeutic candidate for CMT1A and, possibly, for other neuropathies.
Park Tag
Authors: Abineshwaran V. , Anas Ahmmed M. , Sundaramoorthy L. , Vadivelu A. 
Published: March 2024

A major challenge for modern cities is how to maximize the productivity and reliability of urban infrastructure, such as minimizing road congestion by making better use of the limited car parking facilities that are available. We approach a special system for smart parking reservation in a commercial car parking area in an urban environment. This system is mainly designed to avoid unnecessary time conception to find an empty slot in a car parking area. By the same case we can also save more than 80 percentage of fuel wastage in a car parking area to finds the empty parking slot. Car parking problem is a major contributor and has been, still a major problem with increasing vehicle size in the luxurious segment and confined parking spaces in urban cities.
THE DEVELOPMENT OF SCIENTIFIC-BASED E-MODULES TO IMPROVE CONCEPTUAL UNDERSTANDING OF NUTRITION STUDENTS IN BIOTECHNOLOGY SUBJECTS
Authors: Noris M , Nurhajarurahmah St , Darmin Darmin , Iksan Muammar , Alkhair Alkhair , Husnul Khatimah Nur , Zara Avila Dea 
Published: March 2024

The purpose of the study was to develop scientific-based E-Modules in biotechnology courses. This type of research is an R&D research with the 4D method. The research sample involved 30 Nutrition students, Muhammadiyah University of Bima. The results showed that the E-Module developed had a high level of feasibility with a percentage ranging from 86. 93% with a very good category. This shows that the developed E-MODUL is suitable for use as teaching material in biotechnology courses. The developed E-MODUL has characteristics that are simple, flexible, interactive, usability, reusable, maintenable, and easily accessible by lecturers and students. The implication is that the developed E-Module can be accessed by students and lecturers of the nutrition study program, bima muhammadiyah university. There is a need for development by involving augmented reality, so that the presentation is based on factual phenomena.
Comparison of the Prevalence of Risk Factors for Non-Communicable Diseases in the Republic of Belarus and the Republic of Uzbekistan (Data of STEPS Studies)
Authors: Сачек М.М. , Щавелева М.В. , Рустамова Х.Е. , Глинская Т.Н. 
Published: March 2024

Одной из главных причин смертности в мире, по данным ВОЗ, являются неинфекционные заболевания (НИЗ), к которым относятся сердечно-сосудистые заболевания, злокачественные новообразования, хронические заболевания органов дыхания и сахарный диабет. Выявление наиболее распространенных факторов риска и контроль за распространением НИЗ являются необходимыми условиями для построения соответствующих эффективных стратегий в секторе здравоохранения и планирования мероприятий по предупреждению и профилактике НИЗ среди населения. В работе представлен сравнительный анализ результатов исследования распространенности основных факторов риска (ФР) НИЗ среди населения в возрасте 18– 69 лет Республики Узбекистан (2019 г.) и Республики Беларусь (2020 г.). Сопоставление данных STEPS-исследований, выполненных в двух бывших союзных республиках в 2019–2020 гг., выявило повсеместную распространенность ФР НИЗ (несмотря на наличие целого ряда отличий по отдельным параметрам). Как показали STEPS-исследования, на данное явление не влияет модель социально-экономического развития государства, а также тип системы здравоохранения, функционирующий в государстве. Однако с уверенностью можно утверждать, что профилактика ФР, в первую очередь поведенческих, превращает проблему НИЗ из трудноразре- шимой в решаемую. Результаты проведенной работы позволят составить объективное мнение о ситуации с распространенностью факторов риска НИЗ среди взрослого населения стран и являются основой для определения подходов к профилактике НИЗ на предстоящие годы.
One of the main causes of death in the world according to WHO are non-communicable diseases (NCDs), which include cardiovascular diseases, malignant neoplasms, chronic respiratory diseases and diabetes. Identifying the most common risk factors and monitoring the spread of NCDs are necessary conditions for building appropriate effective strategies in the health sector and planning activities to prevent and prevent NCDs among the population. The paper presents a comparative analysis of the results of a study on the prevalence of the main NCD risk factors among the population aged 18–69 years in the Republic of Uzbekistan (2019) and the Republic of Belarus (2020). A comparison of data from STEPS studies carried out in two former Soviet republics in 2019–2020 revealed the widespread prevalence of risk factors for NCDs (despite the presence of a number of differences in individual parameters). As STEPS studies have shown, this phenomenon is not affected by the model of socio-economic development of the state, as well as the type of health care system functioning in the state. However, we can say with confidence that the prevention of risk factors, primarily behavioral ones, turns the NCD problem from intractable to solvable.
Dynamic Evaluation of Glycemic Parameters in Hospitalized Patients with COVID-19
Authors: Дыдышко Ю.В. , Шепелькевич А.П. , Ефремова М.А. , Шишко О.Н. , Юреня Е.В. , Кузьменкова Е.И. , Бруцкая-Стемпковская Е.В. , Лобашова В.Л. 
Published: March 2024

В статье представлены результаты собственных исследований клинико-анамнестических и лабораторных параметров у пациентов с тяжелым течением COVID-19, а также динамическое определение гликемического статуса через 6 месяцев после выписки из стационара с целью выявления возможных предикторов неблагоприятного исхода и оценки прогноза развития нарушения толерантности к углеводам и сахарного диабета. Выполнен ретроспективный анализ клинико-анамнестических и лабораторных параметров 320 пациентов, которые получали медицинскую помощь в условиях отделения интенсивной терапии и реанимации инфекционного стационара г. Минска в период с июня 2020 г. по март 2022 г., а также проведено уточнение гликемического статуса пациентов через 6 месяцев после выписки. У пациентов с госпитальной гипергликемией и сахарным диабетом отмечались более высокие уровни СОЭ, прокальцитонина, СРБ, ЛДГ, нейтрофилов, более выраженная лимфопения, что свидетельствовало о более выраженном воспалительном процессе; также параметры Д-димеров как маркеров коагуляции были выше в указанных группах. Согласно полученным результатам, 70% пациентов с тяжелым течением COVID-19 имели впервые выявленную гипергликемию. Спустя 6 месяцев у 10,3% пациентов отмечены повышенные уровни глюкозы сыворотки крови, что было реклассифицировано в нарушение толерантности к углеводам в 7,5% случаев (3,4% женщин vs. 4,1% мужчин) и у 2,8% пациентов установлен диагноз «сахарный диабет» (0,7% женщин vs. 2,1% мужчин).
The own studies result of clinical, anamnestic and laboratory parameters in patients with severe COVID-19 is presented in the article, as well as a dynamic determination of glycemic status in 6 months outpatient state in order to identify possible predictors of an unfavorable outcome and assess the prognosis for the development of impaired tolerance to glucose and diabetes mellitus. A retrospective analysis of clinical, anamnestic and laboratory parameters of 320 patients who received medical care in the intensive care unit of an infectious hospital in Minsk from June 2020 to March 2022 was performed, and the glycemic status of patients was clarified 6 months after discharge. Patients with hospital hyperglycemia and diabetes mellitus had higher levels of ESR, procalcitonin, CRP, LDH, neutrophils, and more pronounced lymphopenia, which indicated a more pronounced inflammatory process; also, the parameters of D-dimers as markers of coagulation were higher in these groups. According to the results obtained, 70% of patients with severe COVID-19 glucose intolerance in 7.5% of cases (3.4% women vs. 4.1% men) and 2.8% of patients were diagnosed with diabetes mellitus (0.7% of women vs. 2.1% of men).
Some Aspects of Endocrine System Aging
Authors: Мохорт Т.В. 
Published: March 2024

Население мира и Республики Беларусь прогрессивно стареет, что определяет актуальность изучения различных аспектов старения. Роль эндокринной системы в старении неоспорима, но наряду с известными патологическими состояниями имеются менее изученные особенности. Снижение секреции гормона роста, нарушения гипоталамо-гипофизарно-надпочечниковой системы, гипоталамо-нейрогипофизарно-почечной оси и водного гомеостаза, а также и рассмотрение вопросов их потенциальной коррекции являются предметом обсуждения данной публикации.
The population of the world and the Republic of Belarus is progressively aging, which determines the relevance of learning different aspects of aging. The role of the endocrine system in aging is undeniable, but along with the known pathological conditions, there are less studied features. Decreased secretion of growth hormone, disorders of the hypothalamic-pituitary-adrenal system, hypothalamic-neurohypophyseal-renal axis and water homeostasis, as well as consideration of their potential correction are the subject of discussion in this publication.
Habilidades Sociales en la Formación de Estudiantes de Básica y Media: Una Revisión de la Literatura en el Entorno Latinoamericano
Authors: Pherez Gómez Gustavo Adolfo , Villeros Suarez Jose Edilberto , Murillo Ante Elizabeth 
Published: March 2024

Este artículo presenta una revisión de la literatura sobre estudios en educación que muestran métodos para desarrollar las habilidades sociales (HS) en los colegios de educación básica y media de Latinoamérica, identificando que habilidades se desarrollan y su pertinencia. A partir de la revisión realizada en las bases de datos se analizan 21 fuentes, sistematizándolos en una matriz de análisis. Entre los resultados se encontró que las habilidades sociales, como el autocontrol y asertividad, protegen contra el acometimiento de actos infractores. Además, se halló que el clima familiar y el autoconcepto pueden afectar positiva o negativamente en las HS de los estudiantes. Así mismo, se evidencio que la adicción a internet inhibe el desarrollo de las HS. Por otro lado, los programas de intervención, la inclusión de las HS en los diseños curriculares y el desarrollo de habilidades socioemocionales en los docentes, son los métodos utilizados por los colegios de Latinoamérica para el desarrollo de las HS en los estudiantes. Finalmente se concluye que el desarrollo de las HS desde temprana edad promueve en los estudiantes capacidades para enfrentar distintas situaciones sociales, permitiendo que exista una relación saludable con los demás miembros de la comunidad educativa.
PENGARUH MODEL PEMBELAJARAN MULTILITERASI TERHADAP PEMAHAMAN KONSEP MATEMATIS DAN SIKAP BELAJAR PESERTA DIDIK
Authors: Setiya Mukti Langgeng , Mujib Mujib , Suri Froulien Intan , Mardiyah Mardiyah 
Published: March 2024

AbstrakPenelitian ini berawal dari hasil prapenelitian yang menunjukan kemampuan pemahaman konsep matematis yang masih rendah dan sikap belajar peserta didik yang kurang ideal. Sehingga penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran multiliterasi terhadap pengaruh pemahaman konsep matematis dan sikap belajar peserta didik, untuk mengetahui pengaruh model pembelajaran multiliterasi terhadap pengaruh pemahaman konsep matematis, dan untuk mengetahui pengaruh model pembelajaran multiliterasi terhadap pengaruh sikap belajar peserta didik. Penelitian ini dilaksanakan di SMP Negeri 1 Pagelaran, dengan menggunakan sampel sebanyak 2 kelas, yaitu kelas VIII.1 sebagai kelas kontrol dan VIII.4 sebagai kelas eksperimen. Dengan jenis penelitian quasi eksperimen dan design penelitian post-test control design. Teknik analisis data menggunakan uji manova (Multivariate Analysis of Variance) dengan taraf signisikansi 5%. Hasil dari penelitian ini yaitu terdapat pengaruh model pembelajaran multiliterasi terhadap pemahaman konsep matematis dan sikap belajar peserta didik, terdapat pengaruh model pembelajaran multiliterasi terhadap pemahaman konsep matematis, dan terdapat pengaruh model pembelajaran multiliterasi terhadap sikap belajar peserta didik. Kata kunci: Model Pembelajaran Multiliterasi, Pemahaman Konsep Matematis, dan Sikap Belajar.