bluuebunny/crossref_metadata_2025_split huggingface dataset:
W7Nb4O31 Nanorods with a Mixed Crystal Structure: A Very Fast‐ and Stable‐Charging Anode Material for Aqueous Lithium‐Ion Batteries
Authors: Yuan Qiang , Zhu Xiangzhen , Zhao Yan , Wang Lei , Lei Yi , Liu Xuehua , Lin Chunfu 
Published: March 2024

AbstractAqueous lithium‐ion batteries (ALIBs) have attracted extensive interest since the safety problems of traditional lithium‐ion batteries are waived. Although the energy density of ALIBs is improved, their rate capability and power density are still poor due to the slow Li+ diffusivity of the existing anode materials, and their cyclic stability is also poor. Here, W7Nb4O31 nanorods with very fast‐ and stable‐charging capability are explored as a new anode material for ALIBs for the first time. This material owns different tetragonal tungsten bronze (TTB) structures together with 4 × 4 ReO3‐type blocks confined by TTB matrices, allowing abundant pentagonal and quadrangular tunnels for Li+ transport. These large‐sized tunnels combine with the large interlayer spacing (≈3.95 Å) not only lead to extremely fast Li+ diffusivity but also small unit‐cell volume variations (maximum 2.1%) during lithiation/delithiation, thereby enabling the LiMn2O4//W7Nb4O31 full cell to possess excellent rate capability with a 50C versus 1C capacity ratio of 68.3%, ultrahigh power density of 9854 W kg–1, and superior cyclic stability with capacity retention of 89.7/66.7/72.0% at 1C/5C/50C over 1000/10 000/10 000 cycles. This comprehensive study demonstrates that the W7Nb4O31 nanorods are highly promising for fast‐ and stable‐charging ALIBs.
Controlled Formation of Nanoribbons and Their Heterostructures via Assembly of Mass‐Selected Inorganic Ions
Authors: Zhang Xuejiao , Srot Vesna , Wu Xu , Kern Klaus , van Aken Peter A. , Anggara Kelvin 
Published: March 2024

AbstractControl of nanomaterial dimensions with atomic precision through synthetic methods is essential to understanding and engineering of nanomaterials. For single‐layer inorganic materials, size and shape controls have been achieved by self‐assembly and surface‐catalyzed reactions of building blocks deposited at a surface. However, the scope of nanostructures accessible by such approach is restricted by the limited choice of building blocks that can be thermally evaporated onto surfaces, such as atoms or thermostable molecules. Herein this limitation is bypassed by using mass‐selected molecular ions obtained via electrospray ionization as building blocks to synthesize nanostructures that are inaccessible by conventional evaporation methods. As the first example, micron‐scale production of MoS2 and WS2 nanoribbons and their heterostructures on graphene are shown by the self‐assembly of asymmetrically shaped building blocks obtained from the electrospray. It is expected that judicious use of electrospray‐generated building blocks would unlock access to previously inaccessible inorganic nanostructures.
Teflon AF–Coated Nanotextured Aluminum Surfaces for Jumping Droplet Thermal Rectification
Authors: Shimokusu Trevor J. , Nathani Alia , Liu Zhen , Yap Te Faye , Preston Daniel J. , Wehmeyer Geoff 
Published: March 2024

AbstractJumping droplet thermal diodes (JDTDs) are promising candidates to achieve thermal rectification for next‐generation thermal control. However, most prior demonstrations of JDTDs have relied on monolayer‐coated copper‐based superhydrophobic (SHPB) surfaces, while lower‐cost aluminum JDTDs with more durable thin polymeric coatings have not been explored. In this work, a JDTD is constructed that employs SHPB aluminum surfaces coated with protective thin films of Teflon AF (amorphous fluoropolymer) 1601. Measurements for different heating orientations, gap heights (H), and fill ratios (ϕ) show that a maximum thermal rectification ratio of 7 can be achieved for H  =  2.4 mm and ϕ  =  10%. A thermal circuit is demonstrated that uses the JDTD to rectify time‐periodic temperature profiles, achieving thermal circuit effectiveness values up to 30% of the ideal‐diode limit. Coupon‐level durability tests and device‐level cycling show that dip coated Teflon AF enables stable operation of Al JDTDs over >20 cycles, improving on the performance of a monolayer‐coated surface that fails after 5 cycles. The findings of this work signify that Teflon AF coated Al SHPB surfaces can be used for thermal rectification and motivate future research into Al JDTDs for advanced thermal management applications.
Non‐Invasive Flexible Electro‐Mechanical Sensors for Human Respiratory Monitoring and Chronic Disease Management
Authors: Liu Moran , Wang Yiguo , Chen Jing , Zhang Jinyong , Xu Chengsheng , Tang Wei , Zhang Qiming , Li Hui 
Published: March 2024

AbstractAs one of the important physiological signals of the human body, changes in respiration can provide an important reference for human health and is an early warning signal for some chronic respiratory diseases on heart or lung diseases. Usually, doctors combine such changes with electrocardiograph (ECG), electroencephalograph (EEG), electromyography (EMG), and electrooculogram (EOG) results of the patient to make a comprehensive analysis and judgment of the condition. Traditional respiratory monitoring methods have the limitation that portability and accuracy cannot be balanced; while the wearable respiratory monitoring sensors have come into the public's view due to their excellent performances, such as light weight, fast response, not interfering with the subject's daily movement, and maintaining excellent measurement accuracy, which provide more possibilities for the improvement of the performances of the wearable devices applied in the early stage of chronic diseases.
Polaronic Stabilities of Exciton Sensitizers Govern Operational Lifetime of Thermally Activated Delayed Fluorescence Assisted Fluorescence Organic Light‐Emitting Devices
Authors: Moon Yu Kyung , Jang Ho Jin , Shin Dong Jin , Lee Jeeyeon , Lee Jun Yeob , You Youngmin 
Published: March 2024

AbstractThermally activated delayed fluorescence (TADF) assisted fluorescence organic light‐emitting devices (TAF‐OLEDs), also known as hyperfluorescence OLEDs, sometimes have limited operational lifetimes, making them unsuitable for industrial applications. Although, this limitation is believed to originate from the irreversible degradation of constituent materials, the chemical processes underlying this degradation remain elusive. This study enables to better understand the chemical origins of the degradation processes by identifying key degradation intermediates in emission layers comprising 2,8‐di‐tert‐butyl‐5,11‐bis(4‐tert‐butylphenyl)‐6,12‐diphenyltetracene (TBRb) as the fluorescent emitter and 1,4‐azaborin‐based molecules exhibiting multi‐resonance (MR) TADF behaviors, 5,9‐diphenyl‐5,9‐diaza‐13b‐boranaphtho[3,2,1‐de]anthracene (DABNA‐1) and 9‐([1,1′‐biphenyl]‐3‐yl)‐N,N,5,11‐tetraphenyl‐5,9‐dihydro‐5,9‐diaza‐13b‐boranaphtho[3,2,1‐de]anthracen‐3‐amine (DABNA‐2), as exciton sensitizers. Despite the sensitizers facilitating energy transfer to TBRb, they also reduce the device's longevity. While the singlet and triplet excitons of TBRb, as well as excitons of the sensitizers, prove to be relatively stable, the radical ions of the sensitizers prove to be the key limit to device longevity. Comparisons with donor–acceptor‐type TADF exciton sensitizers, 2,4,5,6‐tetrakis(9H‐carbazol‐9‐yl)benzene‐1,3‐dicarbonitrile (4CzIPN), 10,10′‐(sulfonyldi‐4,1‐phenylene)bis[9,10‐dihydro‐9,9‐dimethylacridine] (DMAC‐DPS), and 10‐[4‐(4,6‐diphenyl‐1,3,5‐triazin‐2‐yl)phenyl]‐9,10‐dihydro‐9,9‐dimethylacridine (DMAC‐TRZ), corroborate the findings, pointing to radical ions as primary degradation intermediates. This knowledge is essential for enhancing the durability of TAF‐OLEDs in future designs.
Exploring the Feasibility of Monoclinic‐ZrO2‐Based Memristors as Artificial Olfactory Sensors: An Atomistic Simulation Approach
Authors: Chaurasiya Rajneesh , Chen Kuan‐Ting , Shih Li‐Chung , Huang Ya‐Chi , Chen Jen‐Sue 
Published: March 2024

AbstractMemory devices with sensitivity, selectivity, and operation voltage towards the gases are rarely reported for artificial olfactory sensors. Additionally, there are no reports available on the atomistic aspects of artificial olfactory sensors. This study reports an atomistic simulation of monoclinic‐ZrO2 (m‐ZrO2). The impact of external electric field on the formation of the oxygen vacancies are evaluated by considering the different directions of electric field. Furthermore, it is conducted nudged elastic band calculations which showed a decrease in the migration barrier energy with an increase in the electric field for all considered directions. Moreover, it is simulated the memristor device (Ta/m‐ZrO2/Pt) and investigated the impact of oxygen vacancies on electrical conductivity by considering oxygen vacancies at different locations in m‐ZrO2. Finally, it is evaluated the possibility of using the m‐ZrO2 based memristor device for an artificial olfactory sensor by studying the gas sensing properties of the (111) surface of m‐ZrO2. The pristine structure exhibits low sensitivity towards toxic molecules (CO2, CO, NH3, and NO2), while the sensing performance is significantly enhanced on the oxygen vacancy rich surface. These atomistic simulation results provide an atomic level understanding of the Ta/m‐ZrO2/Pt device and suggest the potential for it to be use as an artificial olfactory sensor.
Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy
Authors: Vinik Yaron , Maimon Avi , Dubey Vinay , Raj Harsha , Abramovitch Ifat , Malitsky Sergey , Itkin Maxim , Ma'ayan Avi , Westermann Frank , Gottlieb Eyal , Ruppin Eytan , Lev Sima 
Published: March 2024

AbstractFerroptosis and apoptosis are key cell‐death pathways implicated in several human diseases including cancer. Ferroptosis is driven by iron‐dependent lipid peroxidation and currently has no characteristic biomarkers or gene signatures. Here a continuous phenotypic gradient between ferroptosis and apoptosis coupled to transcriptomic and metabolomic landscapes is established. The gradual ferroptosis‐to‐apoptosis transcriptomic landscape is used to generate a unique, unbiased transcriptomic predictor, the Gradient Gene Set (GGS), which classified ferroptosis and apoptosis with high accuracy. Further GGS optimization using multiple ferroptotic and apoptotic datasets revealed highly specific ferroptosis biomarkers, which are robustly validated in vitro and in vivo. A subset of the GGS is associated with poor prognosis in breast cancer patients and PDXs and contains different ferroptosis repressors. Depletion of one representative, PDGFA‐assaociated protein 1(PDAP1), is found to suppress basal‐like breast tumor growth in a mouse model. Omics and mechanistic studies revealed that ferroptosis is associated with enhanced lysosomal function, glutaminolysis, and the tricarboxylic acid (TCA) cycle, while its transition into apoptosis is attributed to enhanced endoplasmic reticulum(ER)‐stress and phosphatidylethanolamine (PE)‐to‐phosphatidylcholine (PC) metabolic shift. Collectively, this study highlights molecular mechanisms underlying ferroptosis execution, identified a highly predictive ferroptosis gene signature with prognostic value, ferroptosis versus apoptosis biomarkers, and ferroptosis repressors for breast cancer therapy.
Endogenous Organic–Inorganic Hybrid Interface for Reversible Zn Electrochemistry
Authors: Liu Xingtai , Wang Xiaofang , Yao Jia , Li Jingying , Gan Yi , Wu Ziang , Zheng Junjie , Hao Wenyu , Lv Lin , Tao Li , Zhang Jun , Wang Hanbin , Ji Xiao , Wan Houzhao , Wang Hao 
Published: March 2024

AbstractDespite rechargeable aqueous Zn‐ion batteries (AZIBs) exhibit advantages such as high safety, high specific energy, and low cost, etc, the implementation of Zn anodes is still hampered by insufficient cyclability and grievous side reactions. To improve the cycling stability of the zinc anode, a stable zinc anode/electrolyte interface is needed to suppress dendrite formation and side reactions. Herein, a self‐regulating endogenous organic–inorganic hybrid interface layer (EHI) in situ on the surface of the Zn anode by regulating solvent molecules is constructed. The EHI consists of an organic outer layer containing N─H and ─CH3 and an inorganic inner layer containing ZnO and ZnCO3, which effectively inhibits hydrogen evolution and dendrite growth. Consequently, AZIBs with the EHI achieve a lifespan exceeding 5500 h in 3 mA cm−2, and stripping/plating on copper foils for 600 cycles with an average coulomb efficiency (CE) of 99.47%. This study provides a feasible idea for realizing stable and reversible zinc‐ion batteries.
SHP2 inhibition displays efficacy as a monotherapy and in combination with JAK2 inhibition in preclinical models of myeloproliferative neoplasms
Authors: Pandey Garima , Mazzacurati Lucia , Rowsell Tegan M. , Horvat Nathan P. , Amin Narmin E. , Zhang Guolin , Akuffo Afua A. , Colin‐Leitzinger Christelle M. , Haura Eric B. , Kuykendall Andrew T. , Zhang Ling , Epling‐Burnette Pearlie K. , Reuther Gary W. 
Published: March 2024

AbstractMyeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocytosis, and primary myelofibrosis, are clonal hematopoietic neoplasms driven by mutationally activated signaling by the JAK2 tyrosine kinase. Although JAK2 inhibitors can improve MPN patients' quality of life, they do not induce complete remission as disease‐driving cells persistently survive therapy. ERK activation has been highlighted as contributing to JAK2 inhibitor persistent cell survival. As ERK is a component of signaling by activated RAS proteins and by JAK2 activation, we sought to inhibit RAS activation to enhance responses to JAK2 inhibition in preclinical MPN models. We found the SHP2 inhibitor RMC‐4550 significantly enhanced growth inhibition of MPN cell lines in combination with the JAK2 inhibitor ruxolitinib, effectively preventing ruxolitinib persistent growth, and the growth and viability of established ruxolitinib persistent cells remained sensitive to SHP2 inhibition. Both SHP2 and JAK2 inhibition diminished cellular RAS‐GTP levels, and their concomitant inhibition enhanced ERK inactivation and increased apoptosis. Inhibition of SHP2 inhibited the neoplastic growth of MPN patient hematopoietic progenitor cells and exhibited synergy with ruxolitinib. RMC‐4550 antagonized MPN phenotypes and increased survival of an MPN mouse model driven by MPL‐W515L. The combination of RMC‐4550 and ruxolitinib, which was safe and tolerated in healthy mice, further inhibited disease compared to ruxolitinib monotherapy, including extending survival. Given SHP2 inhibitors are undergoing clinical evaluation in patients with solid tumors, our preclinical findings suggest that SHP2 is a candidate therapeutic target with potential for rapid translation to clinical assessment to improve current targeted therapies for MPN patients.
Synthesis of 1‐amino‐3‐aryl Naphthalenes from Bis(perfluoroalkanesulfonyl)imide with 1,2‐diethynylbenzenes
Authors: Kawamoto Takuji , Yamasaki Tetsushi , Ikazaki Tsubasa , Matsubara Hiroshi , Kamimura Akio 
Published: March 2024

AbstractAlthough the synthesis of vinyl triflates has a long history, the synthesis of vinyl bis(perfluoroalkanesulfonyl)imides has not been reported yet. Here, we report a simple synthetic route to vinyl bis(perfluoroalkanesulfonyl)imides that does not require any additives. The stereoselectivity originates from the steric hindrance between the aryl group and the imide. The reaction proceeds chemoselectively, and subsequent cyclization provides the 1‐amino‐3‐aryl naphthalene derivatives.
Ultra‐Galactocation to Sialic Acid on Tumor Cells with A Penta‐Functional Dendritic Probe for Enhanced Immune‐Killing
Authors: Yang Yuhui , Li Yiran , Wang Caixia , Wang Yuru , Ren Yi , Wu Jie , Ju Huangxian , Chen Yunlong 
Published: March 2024

AbstractGlycans on tumor cell surface have significant impacts in the immune‐killing process. Here an ultra‐galactocation to sialic acid (Sia) strategy is designed to hugely introduce galactose (Gal) to Sia and on tumor cells in vivo by using a penta‐functional dendritic probe (Den@5F), which efficiently enhances the immune‐killing of tumor cells. The Den@5F contains five different kinds of functional groups, including Gal, Cy5, amino, phenylboronic acid (PBA) and 4‐(4‐(hydroxymethyl)‐2‐methoxy‐5‐nitrophenoxy) butanoate (mNB), which can be conveniently prepared through a two‐step reaction. After injecting into the tumor‐bearing mouse, Den@5F can efficiently block Sia through the specific recognition between PBA and Sia on tumor cells and hugely introduce Gal through the subsequent photo‐crosslinking between mNB and amino groups to multiply conjugate excessive Den@5Fs. The comprehensively blocked Sia can prevent the immune escape, and the hugely introduced Gal can promote the immune stimulation of the immune cells, which lead to an efficient enhancement of the immune‐killing. The proposed strategy provides a significant and promising tool to promote the clinical immunotherapy of tumor.
Bis(benzoselenadiazol)ethane: A π‐Extended Acceptor‐Dimeric Unit for Ambipolar Polymer Transistors with Hole and Electron Mobilities Exceeding 10 cm2 V−1 s−1
Authors: Liu Di , Zhao Yinghan , Zhang Jianqi , Wei Zhixiang , Liu Yunqi , Wang Yang 
Published: March 2024

AbstractThe lack of ambipolar polymers with balanced hole (μh) and electron mobilities (μe) >10 cm2 V−1 s−1 is the main bottleneck for developing organic integrated circuits. Herein, we show the design and synthesis of a π‐extended selenium‐containing acceptor‐dimeric unit, namely benzo[c][1,2,5]selenadiazol‐4‐yl)ethane (BBSeE), to address this dilemma. In comparison to its sulfur‐counterpart, BBSeE demonstrates enlarged co‐planarity, selective noncovalent interactions, polarized Se−N bond, and higher electron affinity. The successful stannylation of BBSeE offers a great opportunity to access acceptor‐acceptor copolymer pN‐BBSeE, which shows a narrower band gap, lower‐lying lowest unoccupied molecular orbital level (−4.05 eV), and a higher degree of backbone planarity. Consequently, the pN‐BBSeE‐based organic transistors display an ideally balanced ambipolar transporting property with μh and μe of 10.65 and 10.72 cm2 V−1 s−1, respectively. To the best of our knowledge, the simultaneous μh/μe values >10.0 cm2 V−1 s−1 are the best performances ever reported for ambipolar polymers. In addition, pN‐BBSeE shows an excellent shelf‐storage stability, retaining over 85 % of the initial mobility values after two months storage. Our study demonstrates the π‐extended acceptor‐dimeric BBSeE is a promising acceptor building block for constructing high‐performance ambipolar polymers applied in next‐generation organic integrated circuit.
Modulation by Co (II) Ion of Optical Activities of L/D‐glutathione (GSH)‐modified Chiral Copper Nanoclusters for Sensitive Adenosine Triphosphate Detection
Authors: Ding Qi , Yang Weimin , Xing Xinhe , Lin Hengwei , Xu Chuanlai , Xu Liguang , Li Si 
Published: March 2024

AbstractChiral nanoscale enantiomers exhibit different biological effects in living systems. However, their chirality effect on the detection sensitivity for chiral biological targets still needs to be explored. Here, we discovered that Co2+ can modulate the luminescence performance of L/D‐glutathione (GSH)‐modified copper nanoclusters (L/D−Cu NCs) and induce strong chiroptical activities as the asymmetric factor was enhanced 223‐fold with their distribution regulating from the ultraviolet to visible region. One Co2+ coordinated with two GSH molecules that modified on the surface of Cu NCs in the way of CoN2O2. On this basis, dual‐modal chiral and luminescent signals of Co2+ coordinated L/D−Cu NCs (L/D−Co−Cu NCs) were used to detect the chiral adenosine triphosphate (ATP) based on the competitive interaction between surficial GSH and ATP molecules with Co2+. The limits of detection of ATP obtained with fluorescence and circular dichroism intensity were 9.15 μM and 15.75 nM for L−Co−Cu NCs, and 5.35 μM and 4.69 nM for D−Co−Cu NCs. This demonstrated that selecting suitable chiral configurations of nanoprobes effectively enhances detection sensitivity. This study presents not only a novel method to modulate and enhance the chiroptical activity of nanomaterials but also a unique perspective of chirality effects on the detection performances for bio‐targets.
Modelling spatial distributions of biogenic habitat‐forming taxa to inform marine spatial planning
Authors: Bennion Matthew , Brough Tom , Leunissen Eva , Morrison Mark , Hillman Jenny R. , Rowden Ashley A. , Gordon Dennis P. , Kelly Michelle , Nelson Wendy , Tracey Dianne M. , Macpherson Diana , Neill Kate , Lohrer Andrew M. , Lundquist Carolyn J. 
Published: March 2024

Abstract
Biogenic habitats are foundational habitats for species assemblages and drive a range of ecosystem functions. The Hauraki Gulf/Tiikapa Moana is the most intensively used coastal area in Aotearoa/New Zealand, and decades of commercial fishing, sedimentation and industrialization have degraded biogenic habitats in the Gulf. In response, the marine spatial plan ‘Sea Change’ includes proposals to create new and extend existing marine protected areas (MPAs) and restrict the area open to mobile bottom‐impact fishing methods to conserve and help the recovery of biogenic habitats.
To assess the benefits of different spatial planning scenarios for biogenic habitats, information on their spatial distribution is needed, but data limitations are a significant challenge. Here, an approach is detailed that maximized the information extracted from limited species occurrence data, by incorporating expert knowledge to develop and evaluate models of biogenic habitat‐forming taxa.
Ensemble habitat suitability models (using boosted regression tree and random forest models) were created for 20 biogenic habitat groups. Using withheld data for validation, area under curve (AUC) scores ranged from 0.58 to 0.95 and true skill statistics (TSS) ranged from 0.37 to 0.84, though three models were further evaluated as insufficient representations of known ecological habitats by expert assessors.
Models produced here provide substantially increased information to inform progress on implementation of the Sea Change plan. Two stakeholder processes have been held, resulting in the development of spatial plans for bottom trawl mitigation that are currently under public consultation. Systematic surveys that gather abundance and high‐resolution environmental data should be a priority to improve the utility of predictive models and inform future management processes in the Hauraki Gulf, and funding has been allocated to support additional data collection to determine the effectiveness of spatial management measures in the Hauraki Gulf.
Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis
Authors: Yao Hualiang , Zhang Jie , Zheng Qisheng , Zeng Xianxia , Huang Huaizheng , Ling Zhen , Tang Minghai , Chen Zhiquan , Wang Wenchu , He Linhong 
Published: March 2024

AbstractSelective inhibition of Janus kinase 3 (JAK3) is a promising strategy for the treatment of autoimmune diseases. Based on the discovery of a hydrophobic pocket unutilized between the lead compound RB1 and the JAK3 protein, a series of covalent JAK3 inhibitors were prepared by introducing various aromatic fragments to RB1. Among them, J1b (JAK3 IC50 = 7.2 nM, other JAKs IC50 > 1000 nM) stood out because of its low toxicity (MTD > 2 g/kg) and superior anti‐inflammatory activity in Institute of Cancer Research mice. Moreover, the acceptable bioavailability (F% = 31.69%) ensured that J1b displayed excellent immune regulation in collagen‐induced arthritis mice, whose joints in the high‐dose group were almost recovered to a normal state. Given its clear kinase selectivity (Bmx IC50 = 539.9 nM, other Cys909 kinases IC50 > 1000 nM), J1b was nominated as a highly selective JAK3 covalent inhibitor, which could be used to safely treat arthritis and other autoimmune diseases.