bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting adoption trends for adaptive management of conservation scaling
Authors: Clark Matthew , Pienkowski Thomas , Jagadish Arundhati , Archibald Carla L. , Gelcich Stefan , Govan Hugh , Naidoo Robin , Romero-de-Diego Cristina , Weeks Rebecca , Mills: Morena 
Published: April 2024

Abstract

Achieving global climate, development, and biodiversity goals will require bringing conservation interventions to scale in suitable contexts and with appropriate timing. Practitioners and policymakers have a range of actions available to influence where, when, and by whom an initiative is adopted. Yet, to make effective management decisions, they must have a clear view of the current trajectory towards scaling goals. The non-linearity and variability of scaling processes has, however, hindered forecasting of adoption trends and environmental outcomes. Here, we adapt models of disease transmission to present a simple and flexible modeling structure for forecasting the adoption of conservation initiatives. We tested this framework on empirical adoption data from 19 distinct initiatives. Specifically, we fit the shape of the adoption timeline during the first half of each initiative, estimating the rates of independent uptake and social transmission up to that point. Forecasting the latter 50% of the timeline of cumulative adoption using just these two parameters resulted in an out-of-sample average error of 15.9% across all observations, indicating that this simple formulation captures much of the data-generating process. In one case, we included data on conservation abandonment, extending the cumulative adoption model to estimate the dropout rate and predicting net adoption with an average error of 19.6%, also indicative that this model captures the empirical process reasonably well. We caution against using such models for long-term forecasts, as they are sensitive to multiple assumptions, but instead advocate for their use in adaptive management. Iterative comparisons of forecasts allow users to retrospectively evaluate the impact of decisions and investments. When combined with estimates of environmental outcomes, our framework may provide a comprehensive modeling strategy for identifying targeted management actions and forecasting the impact of conservation projects while considering dynamic social processes.
A stakeholder-driven holistic approach to mitigate drought in Ramsar wetlands: evaluation of nature-based solutions using interval analytic hierarchy process
Authors: Ždero Senka , Srđević Bojan , Srđević Zorica 
Published: April 2024

ABSTRACT

Wetland ecosystems are vital in maintaining the ecological balance of the wider area. The increase of frequent and intense droughts due to accelerated climate changes poses a threat to wetlands as fragile ecosystems which further require a holistic approach and cooperation between stakeholders to define long-term sustainable solutions. This paper focuses on identifying nature-based solutions to mitigate drought in Ramsar-designated sites through understanding the preferences of stakeholders for effective implementation. An interval version of the analytic hierarchy process is proposed as a systematic framework for selecting solutions considering multiple objectives (climate change mitigation, biodiversity preservation, and human welfare) and six alternatives applicable to Ramsar wetlands. The Serbian case study demonstrates the evaluation of alternatives using interval values in pairwise comparison matrices and priority weights were computed by linear programming. Top-ranked measures identified by three experts involve increasing water availability, supporting agroforestry practices, and utilizing natural reservoirs. Mulch and wastewater reuse are excluded due to implementation investments. The added value of the proposed approach is that the results can be used by managers and decision-makers in many ways; for example, weights of the alternatives could indicate resource allocation, while rankings serve as indicators for optimizing the number of applied solutions.
„Uciec od dziennikarzy się nie da” – nowy styl komunikacji medialnej abp. Józefa Glempa po nominacji na urząd prymasa Polski (7 lipca 1981 roku)
Authors: Kindziuk Milena 
Published: April 2024

Prymas Polski Józef Glemp obejmował urząd w zupełnie odmiennej rzeczywistości medialnej niż obecna, w czasach panującej w PRL-u państwowej cenzury. Mimo to podjął współpracę z dziennikarzami. Celem niniejszego artykułu jest zbadanie stylu komunikacji medialnej abp. Józefa Glempa w pierwszych tygodniach po nominacji na urząd prymasa Polski, w okresie od 7 lipca 1981 do 14 września 1981 roku. Materiał badawczy stanowi prasa polska i zagraniczna z okresu lipiec – wrzesień 1981. Dokonano również przeglądu wypowiedzi prymasa dla telewizji polskiej w tym samym okresie oraz przeprowadzono kwerendę dokumentów związanych z początkami sprawowania urzędu prymasa zgromadzonych w trzech archiwach: Archidiecezji Warszawskiej, Sekretariatu Prymasa Polski w Warszawie oraz Konferencji Episkopatu Polski w Warszawie. Przyjęto metody badawcze: desk research, metodę analizy zawartości oraz – pomocniczo – metodę analizy kontekstu dyskursu prasowego. Jak wskazują wyniki podjętej w niniejszym artykule analizy, prymas Polski Józef Glemp stworzył nowy styl komunikacji i współpracy duchownych z mediami oraz przyczynił się do otwarcia Kościoła na media.
The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review
Authors: Zhang Jialang , Feng Mingzhe , Kong Lingbo 
Published: April 2024

Abstract:
Alzheimer's Disease (AD) is the most common cause of dementia, afflicting
over 5 million people in the United States. There remains a lack of effective disease--
modifying treatments for AD beyond a few approved drugs that provide temporary
symptomatic relief. Melatonin is an endogenous hormone mainly produced by the pineal
gland that regulates circadian rhythms and possesses antioxidant and anti-inflammatory
properties. An expansive body of research over the past few decades has investigated
melatonin as a promising therapeutic agent for AD based on its ability to target multiple
pathophysiological processes implicated in AD progression. In this comprehensive review,
we summarize extensive evidence from cellular and animal models that has uncovered
the diverse mechanisms underpinning melatonin's neuroprotective efficacy against
AD pathology. We also synthesize clinical studies examining melatonin's effects on AD
progression and symptoms. Additionally, we discuss how melatonin's multimodal mechanisms,
favorable safety profile, and ability to synergize with conventional therapies
heighten its potential as an effective therapeutic strategy for AD. Rigorously designed
clinical trials incorporating physiological biomarkers are warranted to definitively establish
melatonin's disease-modifying effects. Nevertheless, the considerable preclinical data
support further exploration of melatonin as a therapeutic agent for AD.
Exploring the Mechanism of Bufei Decoction in the Treatment of Bronchial Asthma Based on Network Pharmacology and Molecular Docking
Authors: Han Yong-Guang , Lv Xing , Tan Ya-Lan , Ding Yun-Shan , Zhang Chao-Yun , Bian Hua 
Published: April 2024

Background:
Bufei decoction (BFD) is used in clinical practice to treat bronchial
asthma (BA), although its molecular mechanism of action remains unclear.

Objective:
This study aimed to explore the molecular mechanism of BFD for treating BA.

Methods:
Network pharmacology and molecular docking predicted the molecular mechanism
and the analysis results were verified using the ELISA kit and RT-qPCR.

Results:
There were 58 main active components and 121 potential targets in the BFD from the
Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(
TCMSP), and 11 core targets were obtained from the protein-protein interactions(PPI)
network. The gene ontology (GO) analysis found that the treatment of BA with BFD was mainly
related to inflammatory reaction, membrane raft, cytokine activity, etc. The Kyoto Encyclopedia
of Genes and Genomes (KEGG) pathway enrichment analysis showed that it was mainly related
to interleukin (IL)-17 signaling pathway, tumor necrosis factor (TNF) signaling pathway, PI3KAkt
signaling pathway, etc. The molecular docking results showed that the main active ingredients
had strong binding ability with core targets. BFD significantly reduced the TNF-α, IL-6,
and IL-1β and increased the level of IL-10 in rats with BA. BFD also significantly reduced the
mRNA level of PI3K, AKT1, and VEGFA while increasing the mRNA level of TP53 in rats.

Conclusion:
This study used network pharmacology methods to predict the potential active ingredients,
targets, and pathways of BFD in treating BA and explore its possible molecular
mechanism, which provided a theoretical basis for further study.
Role of Phytoactive-based Nanoformulation for the Treatment of Arthritis
Authors: Kumar Shivendra , Sahu Kantrol Kumar , Agrawal Mohit , Singh Kuldeep , Saha Sunam 
Published: April 2024

Abstract:
Joints and arthritic conditions are among the most dangerous illnesses that humans
have ever encountered and it is even more worrying that there is no recognized treatment for
arthritis. The researchers looked for safer alternatives, such as herbal medicines, because the
traditional treatments used to treat severe joint inflammatory issues have several negative side
effects. A ligand-coated nanomedicine can bind to receptors that are overexpressed by cells in
chronically inflammatory tissues, increasing its efficacy and reducing its systemic side effects.
This is because the pathophysiology of rheumatoid arthritis suggests that macrophages and overexpressed
molecules exist within inflamed tissues, which increases permeability and allows nanomedicines
to accumulate in inflamed tissue and cause retention phenomena. The anti-arthritic
properties of a variety of plants, their components, extracts, and phyto-isolates have been studied
to date. These plant compounds can pose stability and delivery problems, which restricts their
efficacy as a treatment for inflammatory diseases. The multifunctional and adaptable features of
different nanoparticles can help herbal remedies based on nanotechnology get beyond the delivery
constraints of different natural ingredients. The application of nanoformulations in tissue
engineering is an additional strategy for delivering drugs directly to bone and cartilage in RA
patients. The medication is more therapeutically effective due to nanoformulation's improved
synovium and cartilage absorption, accumulation, and penetration at inflammatory joints. Herbal
medications with a nanotechnology foundation exhibit superior pharmacokinetic and drug delivery
qualities, aid in better oral absorption, regulate drug release, boost in vivo retention capacity,
target delivery, and have synergistic effects. This review provides an update on the use of herbal
medicines based on nanotechnology, which show promise in treating arthritis and other ailments.
Post-Translational Modifications in Tau and Their Roles in Alzheimer's
Pathology
Authors: Kalyaanamoorthy Subha , Opare Stanley Kojo , Xu Xiaoxiao , Ganesan Aravindhan , Rao Praveen P.N. 
Published: April 2024

Abstract::
Microtubule-Associated Protein Tau (also known as tau) has been shown to accumulate
into paired helical filaments and neurofibrillary tangles, which are known hallmarks of
Alzheimer’s disease (AD) pathology. Decades of research have shown that tau protein undergoes
extensive post-translational modifications (PTMs), which can alter the protein's structure, function,
and dynamics and impact the various properties such as solubility, aggregation, localization,
and homeostasis. There is a vast amount of information describing the impact and role of different
PTMs in AD pathology and neuroprotection. However, the complex interplay between these
PTMs remains elusive. Therefore, in this review, we aim to comprehend the key post-translational
modifications occurring in tau and summarize potential connections to clarify their impact on the
physiology and pathophysiology of tau. Further, we describe how different computational modeling
methods have helped in understanding the impact of PTMs on the structure and functions of
the tau protein. Finally, we highlight the tau PTM-related therapeutics strategies that are explored
for the development of AD therapy.
Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy
Authors: Luo Jingyuan , Zhang Qianyue , Wang Shutong , Zheng Luojie , Liu Jie , Zhang Yuchen , Wang Yingchen , Wang Ranran , Xiao Zhigang , Li Zheng 
Published: April 2024

Introduction:
UMP-CMP kinase 2 (CMPK2) is involved in mitochondrial DNA synthesis,
which can be oxidized and released into the cytoplasm in innate immunity. It initiates the assembly
of NLRP3 inflammasomes and mediates various pathological processes such as human immunodeficiency
virus infection and systemic lupus erythematosus. However, the role of CMPK2
in tumor progression and tumor immunity remains unclear.

Methods:
We identified CMPK2 expression patterns in the Genotype Tissue-Expression (GTEx),
The Cancer Genome Atlas (TCGA), and the Cancer Cell Line Encyclopedia (CCLE) databases.
Validation was performed using immunohistochemical staining data from the Human Protein Atlas
(HPA) database and qPCR experiments. Receiver operating characteristic curve analysis and
Kaplan-Meier survival analysis were conducted to assess the clinical relevance of CMPK2 expression.
The Estimation of Stromal and Immune Cells in Malignant Tumor Tissues Using Expression
Data (ESTIMATE) algorithm and the Tumor IMmune Estimation Resource (TIMER) database
were used to evaluate the correlation between CMPK2 and immune infiltration in tumors. The Tumor
Immune Syngeneic Mouse (TISMO) database and other public datasets were utilized to assess
the impact of CMPK2 on immune therapy response. MEXPRESS and MethSurv databases
were employed to investigate the effects of methylation on CMPK2 expression.

Results:
CMPK2 expression was elevated in 23 cancers and decreased in two cancers. Furthermore,
CMPK2 expression had a high diagnostic value for 16 cancers. Elevated CMPK2 expression
was associated with lower overall survival (OS), disease-specific survival (DSS), and progression-
free interval (PFI) in four cancers. Immune microenvironment-related analysis revealed
strong associations between CMPK2 expression and immune cell infiltration, as well as immune
checkpoint expression across various tumors. Notably, in four mouse immunotherapy cohorts,
CMPK2 expression in treated mouse tumors was higher post-treatment. In five clinical immunotherapy
cohorts, patients with high CMPK2 expression show better responses to immunotherapy.
Moreover, the methylation level of CMPK2 gene was closely correlated to its expression and
tumor prognosis. Among these cancers, the clinical and immunological indications of skin cutaneous
melanoma (SKCM) are particularly closely related to CMPK2 expression.

Conclusion:
Our analysis preliminarily describes the complex function of CMPK2 in cancer progression
and immune microenvironment, highlighting its potential as a diagnostic and therapeutic
target for immunotherapy.
[Bmim][CF3COO] as a Solvent and a Catalyst for the Knoevenagel
Condensation
Authors: Thi Chung Nguyen , Cong Dung Vo , Xuan Duc Dau 
Published: April 2024

Abstract:
A facile and green strategy for the Knoevenagel condensation reaction of aryl aldehydes
and active methylene compounds using [Bmim][CF3COO] ionic liquid as a solvent and a catalyst has
been introduced. The method features some advantages such as good to excellent yield of products,
relatively short reaction time, mild reaction conditions, broad substrate scope, and scalability. Moreover,
the ionic liquid solvent could be conveniently recycled and reused up to three times without
any considerable loss of catalytic activity. Twelve products were obtained in high yields, and their
structures were confirmed by NMR data. A plausible reaction mechanism involving the role of the
ionic liquid catalyst was also suggested.
Investigation of the Effect of Power and Duration of Ultrasonic Irradiation on the Synthesis of Thiazoles
Authors: Ehsani Eghlima , Sarvary Afshin , Habibzadeh Setareh 
Published: April 2024

Introduction:
The effect of power and duration of ultrasonic irradiation on the synthesis of thiazoles via the Hantzsch reaction was investigated.

Methods:
The reaction of phenacyl bromides with thioamides under ultrasonic irradiation afforded the target thiazoles in good yields.

Results:
The results showed that high power and long irradiation time cause the decomposition of the reaction materials, and for this reaction, the irradiation power of 720 watts and a total duration of 4 minutes, wherein a pulsing function was performed in 50% of each second, were considered the most suitable irradiation properties for the synthesis of thiazoles through the Hantzsch reaction.

Conclusion:
The use of mild conditions, short time frame, high yields, simple separation of the reaction product, and no use of the base for neutralization are the advantages of the present method.
The Teachers’ Knowledge of Type 1 Diabetes in Schools: An Interventional Study
Authors: Assarrar Imane , Zerrouki Dounia , Rami Imane , Draoui Najat , Derbel Salma , El Yamani Nada , Rouf Siham , Latrech Hanane 
Published: April 2024

Background:
Managing type 1 diabetes in school is a real challenge for teachers, parents,
and students themselves. Involving school educators in providing care and support is becoming
more of a necessity than a luxury to facilitate access to healthcare services in schools for
children with type 1 diabetes.

Objectives:
Our work aimed to assess the background knowledge of teachers on type 1 diabetes
and evaluate the impact of an educational intervention in improving this knowledge.

Methods:
We included 346 participants working in elementary schools. We collected data on
anonymous data sheets. Then, a first pre-coded questionnaire was distributed to the participants
to assess their background knowledge of type 1 diabetes. Afterward, a simplified educational
session was delivered to them. Subsequently, the same pre-coded questionnaire was distributed
for evaluation after education.

Results:
Around 84% of the participants recognized polyuria and polydipsia as major signs of diabetes.
Only 35.3% of them knew the definition of hypoglycemia. Hyperglycemia was identified
by 65% of the participants. About 40% believed children cannot exercise, while 55.5% thought
taking free sugar before exercise was mandatory. We found a significant correlation between a
good level of knowledge and knowing a person with diabetes (aOR=2.66, CI95%:1.51–4.70,
p=0.001). There was a significant improvement in knowledge after the educational intervention
(p=0.0001).

Conclusion:
Our study showed a lack of information about type 1 diabetes among teachers. We
also proved the effectiveness of targeted education in correcting misconceptions and encouraging
awareness of type 1 diabetes.
New Aspects of the Medicinal Value of Cornsilk: A Review
Authors: Bhatia Priyansha , Chaturvedi Sushma , Shrivastav Sonika , Alam Md Sabir 
Published: April 2024

:
Cornsilk has been a natural remedy for centuries to treat various medical conditions. Recent
research shows the anti-inflammatory activities of cornsilk extract, which can help relieve pain.
Certain biopeptides are involved in the induction of anti-inflammatory action in the administration of
cornsilk extract. The analgesic activity of cornsilk is due to the presence of tannins and polyphenolic
constituents in Zea mays. Besides maysin, many other factors, such as steroids, flavonoids, volatile
oils, and various phenolic compounds, make cornsilk extract a modern anti-inflammatory and
analgesic drug with minor side effects. In diverse cultures and folk medicines, cornsilk is used for its
diuretic properties, reduction in melanin production properties, and antioxidant, anti-inflammatory,
and analgesic properties. Silver nanoparticles using a combined extract of cornsilk, parsley, and
Arabic gum extract have been reported to reduce inflammation. These effects have been observed in
vivo. This formulation has anti-microbial as well as antioxidant properties. This review article
focuses on the newer aspects of the medicinal value of cornsilk.
Terpenoid Components from Branches and Leaves of Aglaia lawii and
their Biological Properties
Authors: Li Zhi-Xuan , Huang Dan-Yu , Li Yang , Xian Yan-Ying , Zheng Hao , Tian Yun-Cai , Tian Yong , Zhang Wen-Huan , Lin Li-Gen , Gan Li-She 
Published: April 2024

Introduction:
Phytochemical investigation on the twigs and leaves of Aglaia lawii
(Wight) C. J. Saldanha led to the isolation and characterization of sixteen compounds, including five
sesquiterpenoids (1-5), one terpenoidal macrolide (6), seven phenolic compounds (7-13), two
triterpenoids (14-15), and one steroid (16).

Method:
Their structures were identified by spectroscopic analyses and comparison with the literature
data. Eight out of the sixteen compounds were discovered from the genus Aglaia for the first time.

Result:
The sesquiterpenoids (1-5) may serve as important chemotaxonomic markers. In vitro, bioassays
on the anti-inflammatory and anti-diabetic activities of compounds 1‒6 were accomplished.

Conclusion:
Ozoroalide (6) could significantly inhibit LPS-stimulated NO production in RAW264.7
macrophages at 40 μM and caryolane-1,9β-diol (5) could largely increase the glucose uptake capacity
of C2C12 cells under insulin stimulation.
Screening of Some Ayurvedic Phytochemicals to Identify Potential Inhibitors against SARS-CoV-2 Mpro by In Silico Computational Approach
Authors: Alagarsamy Veerachamy , Shyamsundar Potabathula , Narendhar Bandi , Sulthana Mohaideen Thasthagir , Solomon Viswas Raja , Aishwarya Alagarsamy Dharshini , Ravikumar Vemulapalli , Mani Rupeshkumar , Kunchu Kavitha , Gopinath Manavalan , Nivedhitha Subramanian , Parthiban Periyasamy 
Published: April 2024

Background:
The classical drug discovery approach demands more than a decade of strenuous exploration and substantial monetary or economic support, which is difficult in pandemic conditions, such as COVID-19.

Methods:
The main purpose of this work was to ascertain the best inhibitors to combat the SARS-CoV-2 Mpro (PDB ID: 6LU7) target. To achieve this, we conducted a molecular docking screening of 35 phytochemicals from eight different medicinal plants. Using a structure-based drug design of molecular docking, we studied the binding affinities and found 35 molecules that showed greater or identical affinity towards the target than the N3 inhibitor. Additionally, we conducted MD simula-tions for the 6LU7-schaftoside complex.

Results:
The docking analysis has identified several promising phytochemicals with great binding attraction towards the key target. The phytoconstituent, schaftoside (-8.7 kcal/mol), demonstrated the most binding attraction with the target via 6 conventional hydrogen bonds. Additionally, 2'-O-methyl cajanone (-8.3 kcal/mol), isoschaftoside (-8.0 kcal/mol), cajaflavonone (-8.0 kcal/mol), and co-crystal N3 inhibitor (-7.8 kcal/mol) also displayed significant binding affinity. Interestingly, schaftoside and 2’-O-methyl cajanone showed the most promising activities with their low binding energies.

Conclusion:
After thorough analysis, some compounds were found on elite docking sites that re-sembled drugs and had a harmless ADMET profile. Based on the study, it can be concluded that the compounds mentioned earlier possess the ability to be reused as potent inhibitors against the COVID-19 pandemic.