bluuebunny/crossref_metadata_2025_split huggingface dataset:
sp2 Carbon‐Conjugated Covalent Organic Frameworks (sp2c‐COFs): Synthesis and Application in Photocatalytic Water Splitting
Authors: Peng Shiqiong , Wang Renjie , Yang Yao , Wang Shuyan , Liang En , Han Bing , Li Junbo , Yu Xianglin , Zhang Qichun 
Published: February 2025

AbstractPreparation of irreversible sp2 carbon‐conjugated covalent organic frameworks (sp2c‐COFs) with specific porosity, easy structural functionalization, high chemical stability, and unique π‐electron conjugation structure (especially the combination of π–π stacking interactions and conjugation system), can remove the barrier of electron transfer and provide a unique advantage for photocatalytic water splitting. Herein, based on three kinds of reactions (Aldol condensation reaction, Knoevenagel condensation reaction, and Horner‐Wadsworth‐Emmons reaction) and guided by the precise modulation of ligand structure and topology, this review summarizes the synthesis of sp2c‐COFs and their applications in photoelectrocatalytic water splitting (hydrogen evolution and oxygen evolution reactions). Furthermore, challenges and possible research directions for sp2c‐COFs in photocatalytic water splitting are also provided.
COF‐Derived Carbon Materials: Synthesis Strategies and Emerging Applications
Authors: Wang Wenjia , Khan Haroon , Wu Hongwei , Wang Yi 
Published: February 2025

AbstractCovalent organic framework (COF)‐derived carbon materials seamlessly inherit the periodic porous architecture and high specific surface area of their precursors, while simultaneously enabling the confinement of nanoparticles in designated regions. This unique feature mitigates agglomeration, enhances intrinsic properties, and imparts novel functionalities to the resulting materials. Consequently, COF‐derived carbon materials have garnered significant attention across diverse fields, including energy, environmental remediation, and biomedical applications. Despite this burgeoning interest, a comprehensive review encompassing the synthesis, classification, and multifaceted applications of these materials remains scarce. In this context, the state‐of‐the‐art advancements in COF‐derived carbon materials are reviewed systematically here. It categorizes the materials, delineates their primary synthesis strategies, and highlights their versatile applications in catalysis, electrochemical energy storage, water treatment, sensing, and cancer therapy. Lastly, fresh insights into the challenges and future prospects of COF‐derived carbon materials, paving the way for their expanded exploration and utilization are offered here.
Synthesis of Degradable Mainchain Semifluorinated Polyester by CuAAC with Reaction‐Enhanced Reactivity of Intermediate (RERI) Mechanism
Authors: Wu Jiasheng , Li Zheqi , Zhou Zhuo , Yin Xiuzhe , Hou Wangmeng , Shi Yi , Chen Yongming 
Published: February 2025

AbstractQuantitative insertion of functionality into polymer chains via step‐growth polymerization is challenging due to the random bimolecular reaction and relatively low extent of reaction. Herein, a copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) step‐growth polymerization with reaction‐enhanced reactivity of intermediates (RERI) mechanism is applied for the precise insertion of degradable functions into the mainchain semifluorinated polymer and endowed it with controlled degradability. In this CuAAC polymerization, bis‐alkynyl‐terminated (A2) monomer can be quantitatively consumed when the slightly excess of 2,2‐bis(azidomethyl)propane‐1,3‐diyl bis(2‐methylpropanoate) (BiAz, B2) monomer with RERI effect is employed. The CuAAC copolymerization of o‐nitrobenzyl ester‐derived A2 (A2‐ONB), fluorinated A2 (A2‐F), and B2 monomers produced the mainchain semifluorinated copolymers with tunable chemical composition and high molecular weight, along with the random and quantitative insertion of [A2‐ONB] units. These mainchain semifluorinated copolymers are capable of controlled degradation profile under ultraviolet radiation and can undergo complete degradation under basic condition. This work provided a simple approach for preparing mainchain semifluorinated polymers with controlled degradability.
Therapeutic potential of nicotinamide and ABT263 in alcohol‐associated liver disease through targeting cellular senescence
Authors: Gold Naheemat Modupeola , Ding Qinchao , Yang Yang , Pu Shaoyan , Cao Wenjing , Ge Xinxuan , Yang Pengyun , Okeke Michael Ngozi , Nisar Ayesha , Pan Yongzhang , Luo Qiuni , Wang Xiayan , Xu Han , Tian Rui , Zi Meiting , Zhang Xingjie , Li Songtao , He Yonghan 
Published: February 2025

AbstractAlcohol‐associated liver disease (ALD) is a major cause of liver‐related morbidity and mortality, yet clinically effective therapies for ALD remain lacking. Here, we demonstrate that alcohol intake and its metabolite, acetaldehyde (ACH), induce senescence in the liver and liver cells, respectively. To assess the therapeutic potential of targeting liver senescence in ALD, we treated ALD‐affected mice with the senolytic compound ABT263 and the senomorphic NAD+ precursor, nicotinamide (NAM). The results show that ABT263 effectively clears senescent hepatocytes and stellate cells, and reduces liver triglyceride (TG), but increases plasma alanine aminotransferase and TG levels. Conversely, NAM efficiently suppresses senescence and the senescence‐associated secretory phenotype (SASP), protecting the liver from alcohol‐induced injury in ALD mice. RNA‐sequencing analysis revealed that ABT263 treatment downregulated genes involved in adipogenesis while activating the complement pathway. In contrast, NAM upregulated metabolism‐related genes, such as Sirt1, and downregulated DNA damage marker genes, including Rec8 and E2f1, in the liver. These findings suggest that cellular senescence plays a critical role in alcohol‐induced liver injury. Compared with senescent cell clearance by ABT263, suppressing senescence and SASP by NAM may provide a safer and more effective therapeutic approach for ALD.
Recombinant protein HR212 targeting heptad repeat 2 domain in spike protein S2 subunit elicits broad‐spectrum neutralizing antibodies against SARS‐CoV‐2 and its variants
Authors: Lu Ying , Li An‐Qi , Shen Fan , He Wen‐Qiang , Yu Shu‐Heng , Zhao Yan‐Bo , Feng Xiao‐Li , Li Ming‐Hua , Ouyang Songying , Zheng Yong‐Tang , Pang Wei 
Published: February 2025

AbstractSARS‐CoV‐2 variants are under continuous emergence carry numerous mutations within S1 subunit in spike protein and have escaped neutralization through many currently used vaccines and antibodies. The development of next‐generation vaccines is a continuing and long‐term need. In our prior research, the recombinant protein vaccine HR121 targeting the heptad repeat (HR) 1 domain of S2 subunit was constructed, which could evoke highly broad‐spectrum neutralizing antibodies in vivo and confer efficient protective effect on several SARS‐CoV‐2 variants within multiple animal models. Compared with HR1, HR2 domain shows a more conservative degree within SARS‐CoV‐2 and related coronaviruses. Here, we designed a recombinant protein HR212 consisting of HR2–linker1–HR1–linker2–HR2. HR212 showed a high affinity with HR1 and was functionally analogous to HR2 within fusion intermediate in S2 subunit. Immunizing rabbits using HR212‐mediated high nAbs for 28 pseudotyped SARS‐CoV‐2 variants, like currently circulating variants, such as BA.2.86 and JN.1. Transfer of rabbit anti‐HR212 sera or immunization with HR212 offered efficient protective effect on SARS‐CoV‐2 ancestral strain and Omicron BA.2 variant infections of Syrian golden hamsters. According to our results, HR2 domain of S2 subunit is the novel target that can be used to develop broad‐spectrum vaccines to resist SARS‐CoV‐2 variants.
Prediction of Retail Chain Failure: Examples of Recent US Retail Failures
Authors: Berry Shawn 
Published: February 2025

ABSTRACTOver the last several years, several prominent brick‐and‐mortar retail chains have ceased operations, raising concerns that some have referred to as the retail apocalypse. Scholars have attempted to model the likelihood of firm failure using various approaches. This study examines the failures of Bed Bath and Beyond, J.C. Penney, Rite Aid, and Sears Holdings in the United States between 2013 and 2022. Retail failure models that consider internal and external firm factors using both annual reports and macroeconomic data were analyzed and evaluated using logistic regression, PCA, and Random Forest approaches. The findings suggest that EBITDA/Revenue and annual average US inflation rates are strong predictors of retail failure across various modeling approaches. The modeling results provide an early warning signal at least 1–2 years before failure, with accuracies of 93.8%–96.9%.
The Space of Stepanov Type Measure Pseudo S$$ S $$‐Asymptotically Bloch Periodic Functions and Applications to a Nonautonomous Evolution Equation
Authors: Mao Hang‐Ning , Chang Yong‐Kui 
Published: February 2025

ABSTRACTIn this paper, we show some analytic properties on the space of Stepanov type measure pseudo ‐asymptotically ‐Bloch periodic functions at first. We subsequently investigate some existence results of measure pseudo ‐asymptotically ‐Bloch periodic solutions to the semilinear nonautonomous evolution equation with the Stepanov type nonlinear perturbation.
Kinetics Dependence of RAFT Emulsion Polymerization of 2‐Ethylhexyl Acrylate on Initiator Concentrations
Authors: Ni Huanxin , Luo Yingwu 
Published: February 2025

AbstractReversible addition‐fragmentation chain transfer (RAFT) emulsion polymerization with a well‐designed amphiphilic macroRAFT agent as a surfactant has been well‐developed as a powerful tool to synthesize high molecular weight multiblock copolymers. However, the polymerization kinetics research has been mostly limited to styrene polymerization. It has been reported that the dependence of the particle number on initiator concentration is described by Np∝[I]−0.4 in amphiphilic macroRAFT‐mediated emulsion polymerization of styrene, which surprisingly deviates from the classical Smith–Eward equation. In the current study, the dependence of polymerization kinetics on the initiator concentration in the RAFT emulsion polymerization of 2‐ethylhexyl acrylate (EHA) is investigated. It is revealed that the dependence of the particle number on initiator concentration (Np∝[I]−0.29) is similar to that of styrene but the exponent is less. Additionally, compared to styrene polymerization, the inhibition period in EHA polymerization is significantly extended due to the much lower water‐solubility of EHA.
Hisom: Hierarchical Self‐Organizing Map for Solving Multiple Traveling Salesman Problems
Authors: Guan Qingshu , Cao Hui , Zhong Xianjing , Yan Dapeng , Xue Shuangsi 
Published: February 2025

ABSTRACTRecently, routing problems have made significant progress and exhibited remarkable performance across various domains. However, they still suffer from severe issues, including high computational complexity and path intersection phenomenon, which curtail their broader applicability. This study focuses on the challenging and practical Single Depot‐Multiple Traveling Salesman Problem (SD‐MTSP) with a min‐max objective, which aims to minimize the maximum tour length among all salesmen. To tackle these challenges, we propose a Hierarchical Self Organizing Map (HiSOM) based on a divide‐and‐conquer framework to decompose the complex scheduling of SD‐MTSP into task allocation and route planning subproblems, with a strong emphasis on reducing computational complexity. Specifically, in the task allocation stage, we introduce the concept of soft labels to precisely characterize the strength of association between salesmen and their traversal cities, and devise an SGD‐SOM framework to optimize the sum square error with smooth gradient descents. In the route planning stage, we design a TOSOM framework to generate a topologically ordered tour with minimal length, ensuring strict adherence to the convex hull property and effectively mitigating path intersection. Comprehensive experiments on both synthetic and real‐world datasets demonstrate that our proposed HiSOM outperforms numerous baseline methods by up to 6.91%.
Supportive Nursing Care Intervention for Handling Depression and Anxiety Among Mothers of Neonates Admitted in Neonatal Intensive Care Unit (NICU): A Meta‐Analysis
Authors: Zhu Xiaohua , Fan Lijuan 
Published: February 2025

ABSTRACTAimThis study aims to evaluate the effectiveness of supportive nursing care interventions in reducing depression and anxiety among mothers with infants in the neonatal intensive care unit.DesignSystematic review and meta‐analysis.MethodsRandomised controlled trials conducted in mothers with infants admitted to the neonatal intensive care unit with any form of supportive nursing interventions compared to no intervention or usual care in terms of either reduction in depression or reduction in anxiety level of the mothers reported in both groups were included. The GRADE approach assessed the quality of evidence, while the pooled standardised mean difference with 95% confidence intervals (CIs) was calculated using a random‐effects model.ResultsOverall, 18 studies were included. For depression, the pooled standardised mean difference was −0.24 (95% CI: −0.44 to −0.04), indicating a significant reduction in depression levels among mothers receiving supportive nursing care compared to standard care. In anxiety, pooled standardised mean difference was −0.61 (95% CI: −0.96 to −0.25), showing substantial reduction in anxiety levels. GRADE findings indicated moderate quality of evidence for depression and very low quality for anxiety, mainly due to heterogeneity and publication bias in anxiety outcomes.Patient or Public ContributionNo patient or public contribution.
Psychometric Testing of the Mutuality Scale in Patients and Caregiver Dyads After the Onset of Coronary Heart Disease
Authors: Bassola Barbara , Cilluffo Silvia , Bolgeo Tatiana , Simonelli Niccolò , Di Matteo Roberta , Dal Molin Alberto , Rasero Laura , Vellone Ercole , Lusignani Maura , Iovino Paolo 
Published: February 2025

ABSTRACTThis study investigates the psychometric properties of the Mutuality Scale in a sample of patient‐caregiver dyads following a recent episode of coronary heart disease. A cross‐sectional analysis was conducted. Factorial validity was tested with confirmatory factory analysis. Internal consistency reliability was investigated with the model‐based internal consistency reliability index. Pearson's correlation coefficient was used to test convergent validity between mutuality and other theoretical and empirical variables associated with it. We included 150 patient‐caregiver dyads (patient: mean age 65 years, 77% males, 71% married; caregiver: mean age 54 years, 21% males, 71% married). The CFA testing the theoretical four‐factors (love, shared pleasurable activities, shared values, and reciprocity) of mutuality demonstrated adequate fit to the data in both the patient and caregiver version of the scale. Reliability estimates were adequate for the whole scale (model‐based internal consistency index = 0.95). Significant positive correlations were observed between mutuality and self‐care behaviors, and caregiver preparedness, supporting convergent validity. The Mutuality Scale demonstrated satisfactory structural and convergent validity and reliability in patient‐caregiver dyads after the onset of a coronary heart disease event.
Fast Point‐To‐Point Transportation of the Portal Crane via Double‐Input Inversion‐Based Feedforward and Feedback Control
Authors: Zhang Yongli , Li Mengjie 
Published: February 2025

ABSTRACTThis paper describes a double‐input double‐output inversion‐based feedforward control (DIDOIBFC) scheme for fast point‐to‐point (PTP) transportation of the portal crane. Luffing and rotation of the portal crane are two mutually coupled motions in the process of PTP transportation, which are actuated by two control input, respectively. In this paper, the Bessel curve is used to obtain the PTP space transportation trajectory, and the relationship between the luffing length and the rotation angle is fitted into a polynomial function. The control strategy based on inversion system is a two‐point boundary value problem (TPBVP) about the input‐output coordinates of the portal crane. Then, the time‐varying control nominal trajectory (CNT) of the system is obtained by solving a TPBVP for the internal dynamics of the portal crane, and the feedforward controller is designed. In order to realize the anti‐swinging transportation, the gain scheduling feedback controller (GSFC) is designed to stabilize the motion along the feedforward trajectories in real time. When the crane is staying at the start/end point of the transportation or at any other position, the linear quadratic regulator (LQR) controller optimized by the particle swarm optimization (PSO) algorithm is used to keep the system stabilizing. Moreover, in order to improve the robustness of the system, the feedback controller is improved by an feedback control, and the numerical experiments are carried out. Finally, the numerical experiments are carried out. The experimental results verify the effectiveness of the control scheme proposed in this paper, which can realize fast PTP transportation with high efficiency and good stability.
Optimal Timing of Primary Radiosurgical Treatment of Growing Vestibular Schwannoma: Insights From Salvage Microsurgery Outcomes
Authors: Marinelli John P. , Herberg Hans A. , Moore Lindsay S. , Yancey Kristen L. , Kay‐Rivest Emily , Casale Garrett G. , Durham Allison , Khandalavala Karl R. , Lund‐Johansen Morten , Kosaraju Nikitha , Lohse Christine M. , Patel Neil S. , Gurgel Richard K. , Babu Seilesh C. , Golfinos John G. , Roland J. Thomas , Hunter Jacob B. , Kutz J. Walter , Santa Maria Peter L. , Link Michael J. , Tveiten Øystein V. , Carlson Matthew L. 
Published: February 2025

AbstractObjectiveLimited evidence guides the optimal timing of treatment after the detection of tumor growth during the observation of sporadic vestibular schwannoma (VS). The current work aimed to inform the timing of radiosurgical intervention based on an analysis of patient outcomes among those who ultimately failed stereotactic radiosurgery (SRS) and underwent salvage microsurgery.Study DesignA historical cohort study.SettingSeven centers across the United States and Norway.MethodsAdults with sporadic VS who underwent salvage microsurgery following failed primary SRS were included. The primary outcome of interest was the association between tumor size at the time of primary SRS and the ability to achieve gross total resection (GTR) and maintain postoperative House–Brackmann (HB) facial nerve grade I at the last follow‐up after salvage microsurgery.ResultsAmong 96 patients, the median (interquartile range [IQR]) cerebellopontine angle (CPA) tumor size at primary SRS was 14.5 mm (10.0‐19.0). Each 1‐mm increase in CPA tumor size at the time of primary SRS was associated with a 13% increased likelihood of near‐total/subtotal resection or most recent postoperative HB grade >I (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.05‐1.21, P = .001), with an optimal tumor size threshold to distinguish this outcome of 12 mm of CPA extension (c‐index 0.73). Similarly, for each 1‐mm increase in CPA tumor size at the time of primary SRS, a 9% increase in any postoperative complication with salvage microsurgery was observed (OR 1.09, 95% CI 1.02‐1.15, P = .009).ConclusionCorroborated by size threshold surveillance data informing the timing of primary microsurgical resection, the current study suggests that VS outcomes are optimized when primary radiosurgical intervention is undertaken on growing tumors when they harbor 10–15 mm of cerebellopontine angle extension or less.
Harnessing the Antibacterial Potential of Natural Compounds: An In Silico Approach to Combat Dental Caries Caused by Streptococcus mutans
Authors: Pallavi Preeti , Sahoo Pragnya Pramita , Sahoo Adyasha Anapurba , Raut Sangeeta 
Published: February 2025

ABSTRACTAimStreptococcus mutans is a principal cariogenic bacterium responsible for tooth decay, utilizing the enzyme sortase A (SrtA) to anchor surface proteins to its cell wall, thereby forming biofilms. The escalating prevalence of dental caries, coupled with antibiotic resistance and adverse effects of medicines, necessitates the exploration of alternative, safe, and cost‐effective treatment options, preferably derived from plant sources.MethodologyGC‐MS analysis was utilized to identify active compounds of effective plant Psidium guajava. A high‐throughput screening focused on the interaction between these compounds and the target enzyme SrtA using molecular docking was performed.ResultsThirty‐eight compounds were identified from the essential oil of P. guajava leaves through gas chromatography–mass spectrometry analysis. Following pharmacokinetic screening, 37 compounds were selected for molecular docking studies. Notably, cimigenol and caryophyllene oxide emerged as the lead candidate, demonstrating the highest binding energy at −8.1 kcal/mol and −7.0 kcal/mol against SrtA, respectively, but the positive control CHX showed −7.5 kcal/mol using AutoDock. The carbonyl groups within these compounds were identified as pivotal contributors to the inhibition mechanism. Further comparison showed that the most promising compound cimigenol, with a binding energy of −8.1 kcal/mol showed a Gscore of −5.247 kcal/mol, whereas chlorhexidine exhibited the lowest binding affinity of −2.328 kcal/mol when docked using Schrödinger.ConclusionThese findings present a promising avenue for microbial infection therapy by offering a novel repertoire of SrtA inhibitors derived from natural sources and clinically more reliable and potent than CHX.