bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pizza Italia – Indian pizza brand in the battle of David vs Goliath
Authors: Chauhan Himanshu , Panday Priyanka , Upadhyai Raghav , Shukla Gargi Pant 
Published: March 2024

Learning outcomes
This study enables one to critique the importance of adapting and innovating during challenging times to sustain and grow a business and also emphasizes the need for businesses to be flexible, resilient and willing to make necessary changes to stay relevant and thrive in dynamic and unpredictable environments.

Case overview/synopsis
In the competitive world of India’s quick-service restaurants industry, Shilpa Bhatt Bahuguna, the young entrepreneur behind “Pizza Italia,” aimed to secure the top spot in Uttarakhand. Despite facing setbacks by closing six out of the eight outlets during the COVID-19 pandemic, Bahuguna’s focus on product quality and localization had garnered word-of-mouth publicity for her brand. Now, with a limited budget for promotions, Bahuguna sought below-the-line strategies to ensure profitability and success for new outlets. Her determination to establish Pizza Italia as an indigenous brand and her plans for global expansion through franchising reflected her vision for growth and impact in the market. With her entrepreneurial spirit, Bahuguna remained poised to achieve even greater success in the future. Bahuguna aimed to leverage her product quality and word-of-mouth promotion to capture the market. She planned to expand her brand globally and open new outlets in Uttarakhand and London. However, Bahuguna was challenged to promote her brand on a limited budget, favoring “below-the-line” strategies.

Complexity academic level
This case study is appropriate for an undergraduate- or graduate-level program in marketing management.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy
Redesigning and optimizing an electronic device assembly cell through lean manufacturing tools and kaizen philosophy: an application case study
Authors: Al-Rifai Mohammad Hani 
Published: March 2024

PurposeThe purpose of this paper is twofold: first, a case study on applying lean principles in manufacturing operations to redesign and optimize an electronic device assembly process and its impact on performance and second, introducing cardboard prototyping as a Kaizen tool offering a novel approach to testing and simulating improvement scenarios.Design/methodology/approachThe study employs value stream mapping, root cause analysis, and brainstorming tools to identify root causes of poor performance, followed by deploying a Kaizen event to redesign and optimize an electronic device assembly process. Using physical models, bottlenecks and opportunities for improvement were identified by the Kaizen approach at the workstations and assembly lines, enabling the testing of various scenarios and ideas. Changes in lead times, throughput, work in process inventory and assembly performance were analyzed and documented.FindingsPre- and post-improvement measures are provided to demonstrate the impact of the Kaizen event on the performance of the assembly cell. The study reveals that implementing lean tools and techniques reduced costs and increased throughput by reducing assembly cycle times, manufacturing lead time, space utilization, labor overtime and work-in-process inventory requirements.Originality/valueThis paper adds a new dimension to applying the Kaizen methodology in manufacturing processes by introducing cardboard prototyping, which offers a novel way of testing and simulating different scenarios for improvement. The paper describes the process implementation in detail, including the techniques and data utilized to improve the process.
Faculty development program about the food–energy–water nexus: supporting faculty’s adoption of a curricular module and program evaluation
Authors: Mostacedo-Marasovic Silvia-Jessica , Forbes Cory T. 
Published: March 2024

Purpose
A faculty development program (FDP) introduced postsecondary instructors to a module focused on the food–energy–water (FEW) nexus, a socio-hydrologic issue (SHI) and a sustainability challenge. This study aims to examine factors influencing faculty interest in adopting the instructional resources and faculty experience with the FDP, including the gains made during the FDP on their knowledge about SHIs and their self-efficacy to teach about SHIs, and highlighted characteristics of the FDP.

Design/methodology/approach
Data from n = 54 participants via pre- and post-surveys and n = 15 interviews were analyzed using mixed methods.

Findings
Findings indicate that over three quarters of participants would use the curricular resources to make connections between complex SHIs, enhance place-based learning, data analysis and interpretation and engage in evidence-based decision-making. In addition, participants’ experience with the workshop was positive; their knowledge about SHIs remained relatively constant and their self-efficacy to teach about SHIs improved by the end of the workshop. The results provide evidence of the importance of institutional support to improve instruction about the FEW nexus.

Originality/value
The module, purposefully designed, aids undergraduates in engaging with Hydroviz, a data visualization tool, to understand both human and natural dimensions of the FEW nexus. It facilitates incorporating this understanding into systematic decision-making around an authentic SHI.
Getting ahead in the social sciences: How parenthood and publishing contribute to gender gaps in academic career advancement
Authors: Nielsen Mathias Wullum , Pedersen Jens Vognstoft , Larregue Julien 
Published: March 2024

AbstractHow do parenthood and publishing contribute to gender gaps in academic career advancement? While extensive research examines the causes of gender disparities in science, technology, engineering, and mathematics (STEM) careers, we know much less about the factors that constrain women's advancement in the social sciences. Combining detailed career‐ and administrative register data on 976 Danish social scientists in Business and Management, Economics, Political Science, Psychology, and Sociology (5703 person‐years) that obtained a PhD degree between 2000 and 2015, we estimate gender differences in attainment of senior research positions and parse out how publication outputs, parenthood and parental leave contribute to these differences. Our approach is advantageous over previous longitudinal studies in that we track the careers and publication outputs of graduates from the outset of their PhD education and match this data with time‐sensitive information on each individual's publication activities and family situation. In discrete time‐event history models, we observe a ∼24 per cent female disadvantage in advancement likelihoods within the first 7 years after PhD graduation, with gender differences increasing over the observation period. A decomposition indicates that variations in publishing, parenthood and parental leave account for ∼ 40 per cent of the gender gap in career advancement, suggesting that other factors, including recruitment disparities, asymmetries in social capital and experiences of unequal treatment at work, may also constrain women's careers.
Cholinergic interneurons in the shell region of the nucleus accumbens regulate binge alcohol consumption: A chemogenetic and genetic lesion study
Authors: Sharma Rishi , Chischolm Abigail , Parikh Meet , Thakkar Mahesh 
Published: March 2024

AbstractBackgroundBinge drinking, characterized by heavy episodic alcohol consumption, poses significant health hazards and increases the likelihood of developing an alcohol use disorder (AUD). Given the growing prevalence of this behavior and its negative consequences, there is a need to explore novel therapeutic targets. Accumulating evidence suggests that cholinergic interneurons (CIN) within the shell region of the nucleus accumbens (NAcSh) play a critical role in reward and addiction. However, their specific involvement in binge alcohol administration remains unclear. We hypothesized that CIN in the NAcSh regulates binge alcohol consumption.MethodsTo test this hypothesis, we used male ChAT‐cre mice expressing Cre‐recombinase in cholinergic neurons. We performed chemogenetic manipulation using Designer Receptor Exclusively Activated by Designer Drugs (DREADD) to examine the activity, and genetic ablation of CIN in the NAcSh to examine the amount of alcohol consumed in mice exposed to binge alcohol consumption using the 4‐Days Drinking‐in‐Dark (DID) paradigm. The impact of CIN manipulations in the NAcSh on sucrose self‐administration was used to control for taste and caloric effects. Additionally, in a separate group of mice, c‐Fos immunofluorescence was employed to verify chemogenetic activation or inhibition. Histological and immunohistochemical techniques were used to verify microinfusion sites, DREADD expression in CINs, and genetic ablation.ResultsWe found that, while chemogenetic activation of CIN in the NAcSh caused a significant increase in alcohol consumption, chemogenetic inhibition or genetic ablation of CIN significantly reduced the amount of alcohol consumed without affecting sucrose self‐administration. The chemogenetic inhibition caused a significant reduction, whereas activation caused a significant increase, in the number of c‐Fos‐labeled CIN in the NAcSh.ConclusionsOur findings highlight the crucial involvement of CIN in the NAcSh in modulating binge alcohol consumption, suggesting that targeting these neurons could serve to modify alcohol‐related behaviors.
Patients' values and preferences for health states in allergic rhinitis—An artificial intelligence supported systematic review
Authors: Brozek Jan , Borowiack Ewa , Sadowska Ewelina , Nowak Artur , Sousa‐Pinto Bernardo , Vieira Rafael José , Bognanni Antonio , Yepes Nuñez Juan Jose , Zhang Yuan , Zuberbier Torsten , Bousquet Jean , Schünemann Holger J. 
Published: March 2024

AbstractBackgroundAllergic rhinitis (AR) impacts patients' physical and emotional well‐being. Assessing patients' values and preferences (V&P) related to AR is an essential part of patient‐centered care and of the guideline development process. We aimed to systematically summarize the information about patients' V&P on AR and its symptoms and impact on daily life.MethodsWe conducted systematic review in a MEDLINE, Embase, PsychInfo, and CINAHL databases. We included studies which quantitatively assessed patients' V&P for specific outcomes in AR by assessing utilities, applying discrete choice approaches, or rating and ranking outcomes. We grouped outcomes as AR symptoms, functional status, and care‐related patient experience. Study selection and data extraction were supported by the Laser AI tool. We rated the certainty of evidence (CoE) using the GRADE approach.ResultsThirty‐six studies (41 records) were included: nine utility studies, seven direct‐choice studies and 21 studies of rating or ranking outcomes. Utilities were lower with increased AR severity and with the concomitant presence of asthma, but not with whether AR was seasonal or perennial (CoE = low–high). Patients rated AR symptom‐related outcomes as more important than those related to care‐related patient experience and functional status (CoE = very low–moderate). Nasal symptoms (mainly nasal congestion) followed by breathing disorders, general and ocular symptoms were rated as the symptoms with the highest impact.ConclusionsThis systematic review provides a comprehensive overview of V&P of patients with AR. Patients generally considered nasal symptoms as the most important. Future studies with standardized methods are needed to provide more information on V&P in AR.
Ruxolitinib: A new hope for ventilator‐induced diaphragm dysfunction
Authors: Addinsall Alex B. , Cacciani Nicola , Moruzzi Noah , Akkad Hazem , Maestri Alice , Berggren Per‐Olof , Widgren Anna , Bergquist Jonas , Tchkonia Tamara , Kirkland James L. , Larsson Lars 
Published: March 2024

AbstractAimMechanical ventilation (MV) results in diminished diaphragm size and strength, termed ventilator‐induced diaphragm dysfunction (VIDD). VID increases dependence, prolongs weaning, and increases discharge mortality rates. The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway is implicated in VIDD, upregulated following MV. JAK/STAT inhibition alleviates chronic muscle wasting conditions. This study aimed to explore the therapeutic potential of Ruxolitinib, an FDA approved JAK1/2 inhibitor (JI) for the treatment of VIDD.MethodsRats were subjected to 5 days controlled MV (CMV) with and without daily Ruxolitinib gavage. Muscle fiber size and function were assessed. RNAseq, mitochondrial morphology, respirometry, and mass spectrometry were determined.ResultsCMV significantly reduced diaphragm size and specific force by 45% (p < 0.01), associated with a two‐fold P‐STAT3 upregulation (p < 0.001). CMV disrupted mitochondrial content and reduced the oxygen consumption rate (p < 0.01). Expression of the motor protein myosin was unaffected, however CMV alters myosin function via post‐translational modifications (PTMs). Daily administration of JI increased animal survival (40% vs. 87%; p < 0.05), restricted P‐STAT3 (p < 0.001), and preserved diaphragm size and specific force. JI was associated with preserved mitochondrial content and respiratory function (p < 0.01), and the reversal or augmentation of myosin deamidation PTMs of the rod and head region.ConclusionJI preserved diaphragm function, leading to increased survival in an experimental model of VIDD. Functional enhancement was associated with maintenance of mitochondrial content and respiration and the reversal of ventilator‐induced PTMs of myosin. These results demonstrate the potential of repurposing Ruxolitinib for treatment of VIDD.
Pervasive and pernicious underestimation of Asian Americans' support for affirmative action
Authors: Alt Nicholas P. , Goh Jin X. 
Published: March 2024

AbstractPolling data show that 69% of Asian American voters favor affirmative action. However, Asian Americans were featured prominently by the organization Students for Fair Admissions, which played a central role in the Supreme Court's decision to overturn affirmative action. This may distort people's estimates of Asian Americans’ support for affirmative action. Two studies (N = 695) found that people, even Asian Americans, underestimated Asian Americans’ support for affirmative action. Three follow‐up studies (N = 1,625), where we manipulated perceived Asian Americans’ support for affirmative action or the Supreme Court's decision, found no evidence that such information affected White people's support for affirmative action. In Study 6 (N = 365), however, we found that Asian Americans were more likely to agree with the Supreme Court's decision to overturn affirmative action when they saw that a majority of Asian Americans supported the court ruling (relative to a control condition in which no information was presented). This suggests that the widespread misperception of Asian Americans’ support for affirmative action and their central role in the Supreme Court cases may ultimately create a self‐fulfilling prophecy that could shift individual Asian Americans’ own attitude about affirmative action.
Application of prime editing system to introduce TP53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line
Authors: Nguyen Thao , Aida Tomomi , Iijima‐Yamashita Yuka , Tamai Minori , Nagamachi Akiko , Kagami Keiko , Komatsu Chiaki , Kasai Shin , Akahane Koshi , Goi Kumiko , Inaba Toshiya , Sanada Masashi , Inukai Takeshi 
Published: March 2024

AbstractIn childhood acute lymphoblastic leukemia (ALL), TP53 gene mutation is associated with chemoresistance in a certain population of relapsed cases. To directly verify the association of TP53 gene mutation with chemoresistance of relapsed childhood ALL cases and improve their prognosis, the development of appropriate human leukemia models having TP53 mutation in the intrinsic gene is required. Here, we sought to introduce R248Q hotspot mutation into the intrinsic TP53 gene in an ALL cell line, 697, by applying a prime editing (PE) system, which is a versatile genome editing technology. The PE2 system uses an artificial fusion of nickase Cas9 and reverse‐transcriptase to directly place new genetic information into a target site through a reverse transcriptase template in the prime editing guide RNA (pegRNA). Moreover, in the advanced PE3b system, single guide RNA (sgRNA) matching the edited sequence is also introduced to improve editing efficiency. The initially obtained MDM2 inhibitor‐resistant PE3b‐transfected subline revealed disrupted p53 transactivation activity, reduced p53 target gene expression, and acquired resistance to chemotherapeutic agents and irradiation. Although the majority of the subline acquired the designed R248Q and adjacent silent mutations, the insertion of the palindromic sequence in the scaffold hairpin structure of pegRNA and the overlap of the original genomic DNA sequence were frequently observed. Targeted next‐generation sequencing reconfirmed frequent edit errors in both PE2 and PE3b‐transfected 697 cells, and it revealed frequent successful edits in HEK293T cells. These observations suggest a requirement for further modification of the PE2 and PE3b systems for accurate editing in leukemic cells.
Comparison of fluid and body composition measures in women with lipoedema, lymphoedema, and control participants
Authors: Stellmaker Rhiannon , Thompson Belinda , Mackie Helen , Koelmeyer Louise 
Published: March 2024

SummaryLipoedema is the disproportionate accumulation of adipose tissue in the lower body, often associated with hormonal changes in women. Lipoedema is commonly misdiagnosed as lymphoedema or obesity due to similarities in appearance. The aim of this study is to compare body composition and fluid measures of women with lipoedema, lymphoedema, and matched control participants, to determine differences that may help distinguish between each condition. One hundred and eleven participants aged over 18, who presented with the complaint of leg swelling and underwent indocyanine green lymphography were included in this study. Our analysis showed that the individuals with lymphoedema had a significantly higher overall total body water (lymphoedema: 9.6 ± 4.2 L, lipoedema: 7.4 ± 2.3 L, control: 7.5 ± 1.8 L; p < .001) and extracellular fluid (lymphoedema: 4.6 ± 1.6, lipoedema: 3.4 ± 1.0 L, control: 3.5 ± 0.7 L; p < .001) in the legs when compared to individuals with lipoedema and matched control participants. Individuals with lipoedema had a significantly higher overall fat mass as a percentage of body weight when compared to individuals with lymphoedema (lymphoedema: 33.1% ± 9.5%, lipoedema: 39.4% ± 6.5%; p = .003). We are unable to distinguish between individuals with lipoedema and control participants, therefore further research needs to be conducted to help reduce misdiagnosis.
The burden of prenatal and early life maternal substance use among children at risk of maltreatment: A systematic review
Authors: Powell Madeleine , Pilkington Rhiannon , Varney Bianca , Havard Alys , Lynch John , Dobbins Timothy , Oei Ju Lee , Ahmed Tasnia , Falster Kathleen 
Published: March 2024

AbstractIssuesAlthough maternal substance use is a known risk factor for child maltreatment, evidence on the scale of substance use is needed to inform prevention responses. This systematic review synthesised prevalence estimates of maternal substance use during pregnancy and early life among children at risk of maltreatment. Ovid, Pubmed, CINAHL, PsychInfo and ProQuest databases were searched. We included observational studies that sampled children at risk of maltreatment in high‐income countries and reported information on maternal substance use during pregnancy and/or the child's first year of life. We extracted study characteristics and data to calculate prevalence, assessed risk of bias and conducted a narrative synthesis; there were insufficient comparable populations or outcomes to quantitatively synthesise results.Key FindingsThirty five of 14,084 titles were included. Fifteen studies had adequately sized and representative samples to estimate prevalence. Maternal substance use prevalence ranged from 2.4% to 40.6%. Maternal substance use was highest among infants referred to child protection at birth (40.6%) and children in out‐of‐home care (10.4% to 37.2%). Prevalence was higher when studies defined substance use more broadly and when maternal substance use was ascertained from both child and mother records.ImplicationsSupportive, coordinated responses to maternal substance use are needed from health and child protection services, spanning alcohol and other drug treatment, antenatal and postnatal care.ConclusionsPrenatal and early life maternal substance use is common among child maltreatment populations, particularly among younger children and those with more serious maltreatment.
Accounting for uncertainty in marine ecosystem service predictions for spatial prioritisation
Authors: Rullens Vera , Stephenson Fabrice , Townsend Michael , Lohrer Andrew M. , Hewitt Judi E. , Pilditch Conrad A. , Ellis Joanne I. 
Published: March 2024

AbstractAimSpatial assessments of Ecosystem Services (ES) are increasingly used in environmental management, but rarely provide information on the prediction accuracy. Uncertainty estimates are essential to provide confidence in the quality and credibility of ES assessments for informed decision making. In marine environments, the need for uncertainty assessments for ES is unparalleled as they are data scarce, poorly (spatially) defined, with complex interconnectivity of seascapes. This study illustrates the uncertainty associated with a principle‐based method for ES modelling by accounting for model variability, data coverage and uncertainty in thresholds and parameters.LocationTauranga, New Zealand.MethodsA sensitivity analysis was applied on ES models for marine bivalves (Austrovenus stutchburyi and Paphies australis) and their contribution to Food provision, Water quality regulation, Nitrogen removal and Sediment stabilisation. ES estimates from the sensitivity analysis were compared against baseline ES predictions. Spatial uncertainty patterns were analysed for individual ES through bi‐plots and multiple ES through spatial prioritisation using Zonation.ResultsOur study showed spatially explicit differences in uncertainty patterns for ES and between species. Food provision had highest maximum uncertainty (>5 points) but also the largest area of high ES and high certainty conditions. Zonation analysis conducted on baseline and conservative ES values showed overall robust outcomes of top 30% area, but important nuances through shifts in top 5% and 10% areas that allowed for a consistently better representation of ES when accounting for uncertainty.Main ConclusionsThe spatial prioritisation in combination with the ES uncertainty biplots provide tools for spatial planning of individual and multiple ES to focus on area of highest value with highest certainty and can thereby help reduce risk and aid decision‐making at acceptable confidence levels. This type of information is urgently needed in marine ES assessments and their management, but likewise extends to other environments to improve transparency.