bluuebunny/crossref_metadata_2025_split huggingface dataset:
PATHOLOGICAL STUDY ON AMYLOIDOSIS A NEW INDUCTION METHOD OF AMYLOIDOSIS TRYPAN BLUE*
Authors: Uchino Fumiya , Hosokawa Shuji 
Published: December 2008

A high incidence of amyloidosis was induced in mice by repeated subcutaneous injection of trypan blue which lead to a disturbance of the reticulo‐ endothelial system.In this series, the mode of amyloid deposition almost coincided with casein‐induced amyloidosis and differed from senile amyloidosis in mice.As a possible mechanism of the occurrence of amyloidosis in this experiment, it was considered that dysfunction of reticulo‐endothelial cells was provoked by trypan blue‐injection and then amyloid was produced in these cells.Our experiment provided an indirect evidence of cellular secretion of amyloid depending on reticulo‐endothelial cells.
PRIMARY MIXED CARCINOMAS OF THE BRONCHUS
Authors: Chaudhuri M. Ray 
Published: December 2008

Primary mixed carcinomas of the bronchus are found to occur more frequently than previously reported. Forty‐two cases of primary mixed carcinomas of the bronchus were seen at the London Chest Hospital from 1966 to 1969. During this time, 3853 patients were admitted to the hospital and among them 733 had bronchial carcinomas. In 27 instances, the tumour histologically was squamous and adenocarcinomatous in type. Of the other 15; squamous and oat cell characters, and undifferentiated carcinoma of large polygonal cell and adenocarcinomatous characters were present in five instances; adenocarcinoma and oat cell, and undifferentiated carcinoma of large polygonal cell and oat cell characters were present in two instances; and only one had mixed alveolar and oat cell carcinomatous pattern. A study of the pathological changes in these mixed bronchial carcinomas revealed little differences, if any, from a primary bronchial carcinoma.The histogenesis of these mixed carcinomas remains uncertain. The most plausible view is that they arise by divergent differentiation from the descendants of the original multipotent cancer cells. ACTA PATH. JAP. 22:555–564, 1972.
“MAMMALIAN CELLULOSE DISEASE” (“WATAFUKI” DISEASE)
Authors: Toriumi Jun , Shikasawa Haruyuki , Sano Kunitoshi , Komatsu Keiichi 
Published: December 2008

Peculiar fibers not found in nature to our knowledge were observed In the conjunctiva of a 50 years old female. The fibers were identified as cellulose by chemical and X‐ray analysis.Histological and electron microscopical findings suggest that giant cells seen in the granulation tissue of conjunctiva may be responsible for producing these fibers.This disease is considered as an abnormal condition in which mammalian cellulose is produced and the present authors would like to advocate the new term mammalian cellulose disease for this condition. ACTA PATH. JAP. 22:591–612, 1972.
THE ORIGIN OF BRAIN MACROPHAGES – SOME CONSIDERATIONS ON THE MICROGLIA THEORY OF DEL RIO‐HORTEGA –
Authors: Kitamura Tadahisa 
Published: December 2008

In order to determine the origin of brain macrophages, which are considered to be derived from “resting microglia of Hortega”, autoradiographic studies using 3H‐thymidine were carried out to reveal the following results.Almost all the brain macrophages were proved to be derived from circulating leukocytes, especially from monocytes. Other types of cells, including “resting branched microglia of Hortega”, do not play any significant role in the brain macrophage system.Electron microscopic autoradiography revealed marked metamorphosis of monocytes at the vicinity of the lesion, and they were designated as transformed monocytes.On the base of these results and electron microscopic morphology of “resting microglia of Hortega”, the author concluded that Hortega's microglia system can be divided into two different cell groups. The first is that seen In a resting state of mature and immature animals and the second is that appearing in damaged brain. The former Is thought to belong to neuroectodermal glia and the latter to hematogenous cells.
THE EFFECT OF LPF (LEUKOCYTOSIS PROMOTING FACTOR) ON THE KINETICS OF COLONY FORMING CELLS
Authors: Seki Masatoshi , Sato Yuji 
Published: December 2008

Leukocytosis promoting factor (LPF) of Bordetella pertussis and pertussis vaccine (PV) were introduced into C3H/He mice respectively and the kinetics of colony forming cells (CFC) were assayed by modification of Till and McCulloch's method. Uptake of 59Fe and 3H‐thymidine into hematopoietic tissues was also examined with similarly treated mice.In vitro incubation of bone marrow cells with LPF did not cause any particular changes on the development of spleen colonies. Increase of CFC in peripheral blood was significant in both LPF and PV treated animals.In the PV treated mice, erythropoiesis in the spleen and granulopoiesis in the bone marrow were remarkably accelerated on the 5th or 7th day of the injection. The number of CFC in the spleen showed a significant increase, which may result from stimulative effect of bacterial endotoxin. On the other hand, CFC of the spleen and bone marrow were unchanged or slightly decreased in number by administration of LPF, although a temporary stimulation of hematopoiesis was confirmed on the 2nd or 5th day of the injection. The functional derangement of endothelial cells induced by LPF is considered to be the dominant cause of increased CFC in the peripheral blood. The involvement of plural regulatory systems of hematopoiesis has been postulated, based upon the nresent exnerimental results.
AN AUTOPSY CASE OF LÖUFFLER'S ENDOCARDITIS
Authors: Fujioka Yasunori , Fujita Masahiro , Miyakawa Akira , Tsushima Nobuko 
Published: December 2008

An autopsy case of a 34‐year‐old male who had been suspected of having rheumatic myocarditis with eosinophilia was described.At autopsy the heart was remarkably enlarged (780 g) with mural thrombi in both ventricles. Histology revealed features of so‐called fibroplastic parietal endocarditis with eosinophilia or Ldffler's endocarditis. Vascular changes, mainly of arterioles and consisting of endothelial proliferation, thickened intlma, and rarefaction of media were observed in nearly all organs. The etiology and pathogenesis of this condition are at present unknown.
ELECTRON MICROSCOPIC OBSERVATION OF HUMAN HYPERTROPHIED MYOCARDIUM
Authors: Kajihara Hiroki , Taguchi Kazumi , Hara Hiroshi , Iijima Soichi 
Published: December 2008

Hypertrophied muscle cells of the right ventricles obtained from 12 patients with congential malformation of the heart (VSD, TF, A‐V canal and AASV) have been studied by electron microscope.The process of hypertrophy of cardiac muscle cells was almost identical among these cardiac diseases.Slightly hypertrophied muscle cells are characterized by the significant increase of electron lucent cytoplasmic area containing numerous free ribosomes. As the muscle cells become more hypertrophied, synthesis of myofilaments is frequently observed in the subsarcolemmal and Interfibrillar cytoplasmic regions rich in free ribosomes. Numerous dense granules, 150 to 400 mμ in diameter, are noticed with Intimate relation to the well developed Golgi complex and a few elements of rough‐surfaced endoplasmic reticulum. In the markedly hypertrophied muscle cells, the total volume of the contractile elements and the number of mitochondria are conspicuously increased. The central sarcoplasmic core of these cells is expansively extended and contains numerous mitochondria. The synthesis of myofilaments is not recognized in this stage. The appearance of lipofuscin pigments and the enlargement of the nucleus are already noticed in the early period of muscle hypertrophy.
GIANT FOLLICULAR LYMPHOMA OF THE STOMACH – REPORT OF 4 CASES –
Authors: Akagi Tadaatsu , Okajima Kunio , Fujii Yasuhiro , Ishikawa Makoto 
Published: December 2008

Four cases of primary giant follicular lymphoma of the stomach are reported. All patients were males and their ages were 53, 63, 66 and 71 years, respectively. Macroscoplcally, they were divided into 2 cases of ulcerative type, 1 case of polypoid type with hypertrophied rugae and 1 case of diffuse infiltrative type. One case transformed to the diffuse type of lymphosarcoma and died 9 months after gastrectomy.Giant follicular lymphoma could be differentiated from reactive lymphoid hyperplasia, based on the following histological features; uniformity of cellular composition, loss of lymphocytic rim, fusion of follicles, cellular atypism, and lack of phagocytosis and mixed inflammatory infiltrates.
PATHOLOGICAL SYSTEM CONCEPT OF RHEUMATOID ARTHRITIS
Authors: Fassbender H.G. 
Published: December 2008

Rheumatoid arthritis is a disease of the mesodermal germ layer. It is based on two totally different patho‐mechanisms; a) an exudative‐inflammatory process, and b) a primary necrosis of various mesodermal tissues. The exudative‐inflammatory processes take place in the mesodermal spaces; the primary necrotizing processes occur in the interior of various mesodermal tissues. Whereas the lining cell tissue inflammation is non‐characteristic, and the necrosis in rheumatoid arthritis can be taken as specific. The presence of the rheumatoid factor is optional in the lining cell tissue inflammatory processes; it is obligatory in necrosis.Consequently, rheumatoid arthritis is a disease of the mesodermal germ layer which can occur at two levels. On the first level, the process takes place at the border of mesodermal spaces. On the second level, in which the rheumatic factor is obligatory, the process becomes more complicated, since various kinds of mesodermal tissue structures, including heart muscle and vascular walls, die initially. The clinical picture of rheumatoid arthritis is thereafter characterized by the visceral processes.
EXPERIMENTAL AMYLOIDOSIS USING SILVER NITRATE — ELECTRON MICROSCOPIC STUDY ON THE RELATIONSHIP BETWEEN SILVER GRANULES, AMYLOID FIBRILS AND RETICULOENDOTHELIAL SYSTEM —
Authors: Ishihara Tokuhiro 
Published: December 2008

Amyloidosis was experimentally induced in mice by repeated subcutaneous injections of silver nitrate solution.Deposition of silver granules was noted near the amyloid fibrils. The deposition was not prominent in the recently formed amyloid nodules, but abundant in the old nodules. It may be presumed that the deposition of silver granules among the amyloid fibrils suggests the filter‐like nature of amyloid fibrils which take various substances from the blood stream.From the relation of amyloid fibrils and silver granules, the amyloid bundles projecting from the Kupffer cell into the space of Disse were produced by the Kupffer cells and did not indicate the phagocytosis of amyloid by the cells.The mechanism of amyloidosis following injection of silver nitrate and the role of the lysosome of reticuloendothelial cells in the pathogenesis of amyloidosis have been discussed.
ELECTRON MICROSCOPIC INVESTIGATION ON THE ORGANIZATION AND RECANALIZATION OF EXPERIMENTAL THROMBOEMBOLI IN RABBITS
Authors: Horie Akio , Morimatsu Minora , Tanaka Kenzo 
Published: December 2008

Organization and recanalization of experimental thromboemboli were observed by electron microscopy, in pulmonary muscular arteries of rabbits following repeated injections of autologous blood clots.The cells participating in these processes showed the features of young mesenchymal cells, chiefly derived from vascular smooth muscle cells. These mesenchymal cells showed some differentiation towards endothelial cells, fibroblasts, histiocytes and smooth muscle cells.The phagocytosis of fibrin by mesenchymal cells was a common finding in the completely occlusive thromboemboli. This suggested that phagocytosis of fibrin by macrophages might be an important method for its removal in the process of recanalization.Loosely‐arranged endothelial cells with or without tight junctions, the absence of thin basement membranes, and young mesenchymal cells with well‐developed cytoplasmic organellae might be associated with high permeability and growth of newly‐formed capillaries within the organizing thromboemboli.
SOLID CELL NEST (SCN) OF THE HUMAN THYROID GLAND
Authors: Yamaoka Yutaka 
Published: December 2008

In order to study the histological features and the histogenesis of the solid cell nest (SCN) of the human thyroid gland, 388 glands obtained from autopsy cases were examined in detail. The SCN is located in the interfolllcular space, as one or several groups of cells which show a large, light cytoplasm and nucleus. It Is circumscribed by a basement membranelike structure and is separated from the surrounding follicles. The size of the SCN first increases as age increases and then it tends to decrease as age advances further. This is similar to that of the follicles. Although the shape of the SCN usually appears to be round under single histological section, reconstruction revealed that the SCN takes a very irregular form, and that apparently separated groups of SCNs seen in a single section are actually connected with each other and form one SCN. The SCN was found in 81 cases (21%): 74 cases had one SCN, 13 cases had two to four SCNs in one lobe, 4 cases had two to six SCNs in two lobes. It was found in both fetus and aged with equal incidence. The number of SCNs was found equally in two lobes, and never found in the isthmus. No amyloid deposition, keratinizations or intercellular bridges are found in the SCN. Four out of 388 cases examined had aberrant thymus tissues and two of them were located closely to the SCN.Various hypothesis about the histogenesis of the SCN have been reviewed. However, the present study warrants none of them.
ELECTRON MICROSCOPIC STUDIES OF THE SPLEEN AND LIVER IN HEREDITARY SPHEROCYTOSIS
Authors: Matsumoto Noboru , Ishihara Tokuhiro , Shibata Masahiko , Uchino Fumiya , Nakashima Koji , Miwa Shiro 
Published: December 2008

Electron microscopic findings of the red pulp of the spleen and liver from three patients with hereditary spherocytosis have been reported.The sinus lumen of the spleen contained various amounts of red cell with reduced deformability. Pronounced engorgement of erythrocytes in the cordal space and various stages of erythrophagocytosis by the cordal macrophages were characteristic findings. The sinus lining cells also showed erythrophagocytosis and contained numerous dense bodies. Cordal macrophages and fibrous elements seemed to be more increased in the older patient.Acid phosphatase activity of varied intensity was demonstrated in the erythrophagocytic vacuoles of cordal macrophages. As the intracellular degradation progressed, more intense activity of this enzyme was noted, indicating their lysosomal origin.Splenic conditioning and enhanced destruction of defective red cells in the spleen were the main cause of hemolysis in hereditary spherocytosis.In the liver, erythrophagocytosis by the Kupffer cells was also not infrequently noted, but the liver was estimated to play a minor role in HS.The mechanism of hemolysis and the role of the spleen and liver in elimination of hereditary spherocytes have been discussed.
TWO AUTOPSY CASES OF ATYPICAL MYELOPROLIFERATIVE DISORDER WITH GROUP C MONOSOMY OCCURRING IN SIBLINGS
Authors: Kamiyama Ryuichi , Shibata Toshikatsu , Mori Wataru 
Published: December 2008

Two cases of atypical myeloproliferative disorder with monosomy of of a group C chromosome are described, which, to our best knowledge, are the first report of autopsied cases occurring in siblings.Discussions are made mainly on the role of the group C chromosome in homeostatic control of hematopoiesis, with a short review of previously reported cases of similar or related conditions.Appearance of relatively small megakaryocytes, with more or less decreased amount of PAS positive materials in their cytoplasm and vague platelet demarcation membrane, in our cases is also mentioned, which seemed to be responsible for clinically detected thrombocytopenia, to some extent.
ULTRASTRUCTURAL and HISTOCHEMICAL STUDIES OF VASCULAR LESIONS IN MARFAN'S SYNDROME, WITH REPORT OF 4 AUTOPSY CASES
Authors: Takebayashi Shigeo , Kubota Isamu , Takagi Toshihiko 
Published: December 2008

Histochemical observation was conducted on arterial lesion in 4 cases of Marfan's syndrome and electron microscopic observation was also carried out on the aorta and gastroepiploic artery in 2 of the 4 cases. Acid mucopolysaccharide (AMPS) noted In cystic medionecrosis demonstrated meshwork of spheres and threads, and showed the same structure as the ground substances widely distributed in the mesenchymal connective tissues including normal arteries and as AMPS in cystic medionecrosis‐like lesions such as arteriosclerosis, mesoaortitis syphilitica, and aortitis syndrome (Takayasu's disease). In histochemical observation, there was found no distinct qualitative difference between AMPS in Marfan's syndrome and that in controls. The overaccumulation of AMPS is not a direct cause of vascular lesions in Marfan's syndrome.The pattern of degeneration of elastic fibers was peculiar to Marfan's syndrome but it also resembled senile change. Degeneration of elastic fibers was accompanied by regeneration in the same area. There was observed no electron microscopic anomaly in collagen fibers nor was found anomaly of fibrlllogenesis in media smooth muscle cells. From the point of view of cell pathology, attribution of the cause of vascular lesion merely to some enzyme deficiency results in much contradiction.
AN EXPERIMENTAL STUDY ON THE SIGNIFICANCE OF THE BONE MARROW LYMPHOCYTE IN HAEMATOPOIETIC REGENERATION FOLLOWING ACUTE INJURY DUE TO 60CO IRRADIATION and CYTOTOXIC DRUGS*
Authors: Tange Tsuyoshi 
Published: December 2008

Haematopoietic cells of the rat bone marrow were killed almost completely by using hydroxyurea (OHU), cytoslne arabinoslde (ara‐C), 60Co irradiation and busulfan. The relation between the regeneration of haematopoietic cells of the bone marrow and the behavior of the bone marrow lymphocytes and related cells was investigated quantitatively.Bone marrow lymphocytes and related cells were cytologlcally classified Into lymphocytes, transitional cells and blastic cells on the smeared preparation.Comparing the results of the experiment using OHU 2.5 g/kg with those using whole body irradiation of 60Co 700R, the absolute number of nucleated cells In the bone marrow was reduced more prominently in the former case than in the latter. Nevertheless, regeneration of haematopoietic cells began earlier In the former case than in the latter.In the experiment using OHU 2.5 g/kg, haematopoietic cells in the bone marrow almost completely disappeared promptly after the treatment. On the contrary, the bone marrow lymphocytes were rather well preserved, making up 59% of control on the 1st day and 54% on the 2nd day. Moreover, it was evident that the decrease in number of bone marrow lymphocytes and the increase in number of transitional and blastic cells occurred simultaneously around the 4th day after the last dosage, just prior to the haematopoietic regeneration.On the 8th day after whole body irradiation with 60Co 700R, in parallel with the appearance of haematopoietic regeneration, the bone marrow lymphocytes, transitional cells and blastic cells were the predominant populations In the regenerating bone marrow.In the experiment using ara‐G 600 mg/kg, the number of transitional cells increased evidently prior to haematopoietic regeneration.The author concluded that regeneration of bone marrow haemato‐poiesis can take place earlier and more rapidly, when the bone marrow lymphocytes are provided In sufficient numbers.
BEHÇET SYNDROME ASSOCIATED WITH NASAL MALIGNANT LYMPHOMA – REPORT OF AN AUTOPSY CASE –
Authors: Kaneko Hiroshi , Höjö Yukimitu , Nakajima Hiroshi , Okamuba Akiharu , Fukase Masayuki , Katano Akira 
Published: December 2008

The present case deals with a patient who was suffering concurrently from malignant lymphoma of the nasal cavities and Behcet disease accompanied with colitis ulcerosa.A possibility that Behçet syndrome might be accompanied with malignant tumor is discussed. Moreover, it may be possible to point out the presence of such a type of Behçet syndrome as a “tumoral Behcet”.
AN AUTOPSY CASE OF PRIMARY CYTOMEGALIC INCLUSION ENTERITIS WITH REMARKABLE HYPOPROTEINEMIA*
Authors: Tajima Tatsuro 
Published: December 2008

An autopsy case of characterltic and severe enteritis with remarkable hypoproteinemla and extensive ulceration having numerous cytomegalic inclusion cells In the mucosal and submucosal capillary endothelia was reported.The pathological findings of this case proved the previous author's opinion that the ulcerative lesions in the digestive tract of the cytomegalic inclusion disease were caused by the cytomegalovirus and the systemic cytomegaloviral infection in the body occurred from the ulcerative lesions.The author advocates that this case be termed as “primary cytomegalic inclusion enteritis”, because this case has no serious basic diseases or pathologically severe extensive lesions in the small intestinal tract, and has received no immunosuppressive treatment.
PATHOLOGY OF ULCEROGENIC AND DIARRHEOGENIC TUMORS OF THE PANCREAS
Authors: Tomita Tatsuo 
Published: December 2008

Ulcerogenic and diarrheogenic tumors of the pancreas were studied both light and electron microscopically in the documented cases of two different kinds of tumors to elucidate the histogenesis of non‐beta islet cell tumors in reference to islet cells of the normal pancreas.Argyrophil stain for delta (D) islet cells revealed a few limited number of argyrophil tumor cells, suggesting some relationship to D islet cell as being origin of the ulcerogenic tumor. Alpha (A) cells were not detected in either of ulcerogenic or diarrheogenic tumors. Electron microscopic finding is more confusing. Z‐E tumor granules are heterogenous and variable in relatively smaller sizes of 100–130 mμd 170–200 mμ Diarrheogenic tumors have more homogenously smaller granules (100–130 mμ) with minor components of intermediate sizes (150–200 mμ).Thus, both ulcerogenic and diarrheogenic tumors are quite different from D islet cells (average granule‐350 mμ) or antral G cells (average granule‐250 mμ), both of which are two different gastrin‐producing cells.A tentative conclusion will be that ulcerogenic tumors originate from gastrin cell similar to antral G cell and diarrheogenic tumors stem from gastrin‐antagonist producing cell, presumably similar to the gastric inhibitory peptide (G.I.P.) cell of the small intestine.
EARLY ULTRASTRUCTURAL CHANGES OF EPITHELIAL CELLS OF THE GLANDULAR STOMACH IN RAT INDUCED BY N‐METHYL‐N'‐NITRO‐N‐NITROSOGUANIDINE
Authors: Tahara Eiichi 
Published: December 2008

The early ultrastructural events that occur In the gastric epithelial cells of the glandular stomach of rat from 12 hours to 3 weeks after oral administration of N‐methyl‐N'‐nitro‐N‐nitrosoguanidine were examined and compared with the X‐irradiation effects on mouse gastric mucosa. The mucoid cells of the pyloric mucosa, particularly the surface and pit mucous cells exhibited the greatest ultrastructural alterations among the 6 types of gastric epithelial cells. The earliest changes of the mucoid cells were observed in the nuclei, and were characterized by the sequential development of first nucleolar enlargement, which consisted of the increase of both the fibrillar and granular components, followed by the occurrence of nucleolar segregation, reduction and clumping of the chromatin, and irregularity of the nuclear membrane. Significant degenerative changes of the cytoplasm in the mucoid cells could be observed after these nuclear alterations. Later, giant cell formation in the mucoid cells and mesenchymal cells, and the development of epithelial cells containing two cell specificity were found.These ultrastructural alterations of the mucoid cells seem to represent the morphologic manifestations of biochemical interaction between N‐methyl‐N'‐nitro‐N‐nitrosoguanidine and biological materials.