bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of 4,4′‐Disubstituted Azepines via Ring‐Closing Metathesis Reaction and Asymmetric Arylation of Lactones.
Authors: Delhaye Laurent , Merschaert Alain , Diker Khalid , Houpis Ioannis N. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Mediated Intramolecular Aryl Amination on Furanose Derivatives: An Expedient Approach to the Synthesis of Chiral Benzoxazocine Derivatives and Tricyclic Nucleosides.
Authors: Neogi Arpita , Majhi Tirtha Pada , Mukhopadhyay Ranjan , Chattopadhyay Partha 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of β‐Aminophosphonates and Study of Their Acid—Base Properties and Phase Distribution in Water—Organic Solvent Systems.
Authors: Cherkasov R. A. , Galkin V. I. , Khusainova N. G. , Mostovaya O. A. , Garifzyanov A. R. , Nuriazdanova G. Kh. , Krasnova N. S. , Berdnikov E. A. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1,2‐Azaphospholanes Containing an Amino Acid Fragment
Authors: Bykhovskaya O. V. , Aladzheva I. M. , Lobanov D. I. , Petrovskii P. V. , Lyssenko K. A. , Fedyanin I. V. , Mastryukova T. A. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Michael Additions of a Chiral Phosphite to Nitroalkenes and Knoevenagel Acceptors.
Authors: Enders Dieter , Tedeschi Livio , Foerster Dominik 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Indole Diterpenoid Synthetic Studies. Construction of the Heptacyclic Core of (‐)‐Nodulisporic Acid D (I).
Authors: Smith Amos B. III , Davulcu Akin H. , Kuerti Laszlo 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Simultaneous Protection and Activation of Amino Acids Using Propargyl Pentafluorophenyl Carbonate.
Authors: Ramesh Ramapanicker , Rajasekaran Sakthidevi , Gupta Rohit , Chandrasekaran Srinivasan 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bifunctional Acyclic Nucleoside Phosphonates. Part 1. Symmetrical 1,3‐Bis[(phosphonomethoxy)propan‐2‐yl] Derivatives of Purines and Pyrimidines.
Authors: Vrbovska Silvie , Holy Antonin , Pohl Radek , Masojidkova Milena 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of C‐5 Substituted Cidofovir Derivatives.
Authors: Krecmerova Marcela , Masojidkova Milena , Holy Antonin 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Series of 5‐Aminosubstituted 4‐Fluorobenzyl‐8‐hydroxy‐[1,6]naphthyridine‐7‐carboxamide HIV‐1 Integrase Inhibitors.
Authors: Guare James P. , et al. et al. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gatifloxacin Derivatives: Synthesis, Antimycobacterial Activities, and Inhibition of Mycobacterium tuberculosis DNA Gyrase.
Authors: Sriram Dharmarajan , Aubry Alexandra , Yogeeswari Perumal , Fisher L. M. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amidines (Imidamides) N‐Substituted by Metals, Halogens, Oxygen, and Other Heteroatoms
Authors: Ostrowska K. , Kolasa A. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Chemical Transformations of 2,3‐Dihydropyrrole‐2,3‐diones Anellated on the [a] Side by Azaheterocycles
Authors: Mashevskaya I. V. , Maslivets A. N. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
NBI 30775 (R121919): An Orally Active Antagonist of the Corticotropin‐Releasing Factor (CRF) Type‐1 Receptor for Treatment of Anxiety and Depression
Authors: Chen Chen , Grigoriadis Dimitri E. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Six‐Membered Ring Spirans: Carbocycles and Heterocycles with Oxygen
Authors: Cismas C. , Terec A. , Mager S. , Grosu I. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Distress and post‐traumatic stress disorders in high risk professionals: adult attachment style and the dimensions of anxiety and avoidance
Authors: Declercq Frédéric , Willemsen Jochem 
Published: August 2006

AbstractThis study examines the relationship between adult attachment and psychological distress in a population of 544 people working for a security company and for the Belgian Red Cross. The results indicate that fearful–avoidant and preoccupied attached individuals report more stress than secure attached and insecure attached individuals of the dismissive type. Next, the same attachment styles appear to differentiate between individuals who do and individuals who do not develop a post‐traumatic stress syndrome (PTSD) after being confronted with a critical incident. Breaking the attachment styles into the two underlying dimensions of attachment anxiety and avoidance, our results suggest that anxiety is more of an issue than avoidance in psychological distress and the occurrence of PTSD. Copyright © 2006 John Wiley & Sons, Ltd.
Separation of doxorubicin and doxorubicinol by cyclodextrin‐modified micellar electrokinetic capillary chromatography
Authors: Eder Angela R. , Chen Jennifer S. , Arriaga Edgar A. 
Published: August 2006

AbstractDoxorubicinol (DOXol) is a human metabolite of the chemotherapy agent doxorubicin (DOX), and is associated with dose‐dependent cardiotoxicity and decreased drug efficacy. Due to the structural similarities and equal molecular charges of DOXol and DOX, their electrophoretic separation is commonly ineffective. A method for separating and detecting DOX and DOXol, as well as two DOXol enantiomers, was established using cyclodextrin‐modified micellar electrokinetic capillary chromatography with laser‐induced fluorescence detection. Differential DOXol production was detected in a DOX‐sensitive and resistant pair of cell lines, with a 0.08 ± 0.01 fmol limit of detection.
Characterization of UV‐transparent capillaries for CEC and CE
Authors: Bandilla Dirk , Cabral Jean‐Louis , Skinner Cameron D. 
Published: August 2006

AbstractThis short communication describes features of UV‐transparent capillaries employed for CEC and CE. A waveguide effect was observed when using UV‐transparent capillaries. Through imaging with SEM, the UV‐transparent coating was found to be highly porous unlike polyimide coating, which did not exhibit any porosity at all. Prolonged exposure to several commonly employed solvents with elevated pH caused abrasion of the coating at the capillary tip but no swelling of the UV‐transparent coating was observed. Lastly, four different cutting techniques were compared to obtain smooth capillary tips.
Biodegradable Polyesters Based on cis‐1,4‐Butenediol
Authors: Chatti Saber , Behnken Gesa , Langanke Dennis , Kricheldorf Hans R. 
Published: August 2006

AbstractSummary: Homopolyesters based on cis‐1,4‐butenediol (cBeD) and aliphatic dicarboxylic acids (ADAs) were prepared by three different methods. First, cBeD was polycondensed with the dimethyl esters of ADAs in bulk. Regardless of the catalyst, only low‐molar‐mass polyesters were obtained. Second, polycondensations of cBeD with ADA dichlorides catalyzed by pyridine yielded polyesters with $\overline M _{\rm n}$ in the range of 8 000–13 500 Da. $\overline M _{\rm n}$ around 20 000 Da were achieved when the ADA dichlorides were polycondensed with DSDEN. These ring‐opening polycondensations were optimized by a broad variation of the reaction conditions. Under optimized conditions a high molar fraction of cyclic polyesters was formed. All polyesters proved to be crystalline with melting temperatures (Tm) in the range of 55–120 °C.Polycondensations of cBeD.magnified imagePolycondensations of cBeD.
Fabrication of Silver Nanoparticles in Hydrogel Networks
Authors: Mohan Y. Murali , Premkumar Thathan , Lee Kyungjae , Geckeler Kurt E. 
Published: August 2006

AbstractSummary: This paper describes a simple and facile approach to fabricate well dispersed silver nanoparticles (AgNPs) in poly[N‐isopropylacrylamide‐co‐(sodium acrylate)] hydrogels. The silver nanoparticles formed are spherical in shape with a narrow size distribution in the hydrogel networks in which the nanoparticles are stabilized by the polymer network. Uniformly dispersed silver nanoparticles were obtained with poly[N‐isopropylacrylamide‐co‐[sodium acrylate)] hydrogels, whereas a poly(N‐isopropylacrylamide)/poly(sodium acrylate) IPN gel showed aggregated nanoparticles. It is demonstrated that the hydrogel network structure determines the size and shape of the nanoparticles. These particles are more stable in the gel networks compared to other reduction methods. The hydrogel/silver nanohybrids were well characterized by XRD, UV‐vis spectrometry, scanning electron microscopy and transmission electron microscopy.Schematic representation of the preparation of Ag nanoparticles in hydrogel networks.magnified imageSchematic representation of the preparation of Ag nanoparticles in hydrogel networks.
Surprising Effects on the Conformational Entropy due to Nonrandom Distributions of Local Conformations Along Unperturbed Chains
Authors: Mattice Wayne L. , Waheed Numan , Erguney Fatih 
Published: August 2006

AbstractSummary:Nonrandomness in the distribution of rotational isomeric states along a flexible unperturbed chain reduces its conformational entropy. Pairwise interdependence of the bonds is a necessary, but not sufficient, condition for a significant reduction. The reduction in conformational entropy from this source can be as severe as a factor of three. It is generally more severe for isotactic chains than for the syndiotactic chains constructed from the same monomer. Surprising effects are sometimes seen, such as the nearly identical reductions in conformational entropy for polydimethylsiloxane, a very flexible chain, and for poly(methyl methacrylate), a much stiffer chain.Fractional difference in conformational entropy due to nonrandomness versus probability of helix in helix‐coil transition.magnified imageFractional difference in conformational entropy due to nonrandomness versus probability of helix in helix‐coil transition.
Smoking and cancer‐related gene expression in bronchial epithelium and non‐small‐cell lung cancers
Authors: Woenckhaus M , Klein‐Hitpass L , Grepmeier U , Merk J , Pfeifer M , Wild PJ , Bettstetter M , Wuensch P , Blaszyk H , Hartmann A , Hofstaedter F , Dietmaier W 
Published: August 2006

AbstractTobacco smoking is the leading cause of lung cancer worldwide. Gene expression in surgically resected and microdissected samples of non‐small‐cell lung cancers (18 squamous cell carcinomas and nine adenocarcinomas), matched normal bronchial epithelium, and peripheral lung tissue from both smokers (n = 22) and non‐smokers (n = 5) was studied using the Affymetrix U133A array. A subset of 15 differentially regulated genes was validated by real‐time PCR or immunohistochemistry. Hierarchical cluster analysis clearly distinguished between benign and malignant tissue and between squamous cell carcinomas and adenocarcinomas. The bronchial epithelium and adenocarcinomas could be divided into the two subgroups of smokers and non‐smokers. By comparison of the gene expression profiles in the bronchial epithelium of non‐smokers, smokers, and matched cancer tissues, it was possible to identify a signature of 23 differentially expressed genes, which might reflect early cigarette smoke‐induced and cancer‐relevant molecular lesions in the central bronchial epithelium of smokers. Ten of these genes are involved in xenobiotic metabolism and redox stress (eg AKR1B10, AKR1C1, and MT1K). One gene is a tumour suppressor gene (HLF); two genes act as oncogenes (FGFR3 and LMO3); two genes are involved in matrix degradation (MMP12 and PTHLH); three genes are related to cell differentiation (SPRR1B, RTN1, and MUC7); and five genes have not been well characterized to date. By comparison of the tobacco‐exposed peripheral alveolar lung tissue of smokers with non‐smokers and with adenocarcinomas from smokers, it was possible to identify a signature of 27 other differentially expressed genes. These genes are involved in the metabolism of xenobiotics (eg GPX2 and FMO3) and may represent cigarette smoke‐induced, cancer‐related molecular targets that may be utilized to identify smokers with increased risk for lung cancer. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The role of social cognitive processing theory and optimism in positive psychosocial and physical behavior change after cancer diagnosis and treatment
Authors: K. Harper Felicity W. , Schmidt John E. , Beacham Abbie O. , Salsman John M. , Averill Alyssa J. , Graves Kristi D. , Andrykowski Michael A. 
Published: August 2006

AbstractThe physical and psychosocial ‘health’ behaviors of cancer patients have become a more pressing issue as 5‐year survival rates continue to rise. This study investigated: (a) the extent of positive change in four psychosocial behaviors and two physical health behaviors, (b) the role of psychosocial predictors (drawn from theories of Social Cognitive Processing and optimism) in positive behavior change after cancer diagnosis and treatment, and (c) the possible influence of social desirability in reports of positive psychosocial and physical behavior change. The behavior showing the greatest positive change was time spent reflecting on life priorities; the behavior that was least likely to change after diagnosis and treatment was exercise. Optimism, social support, and cancer‐related intrusions were positively associated with increases in physical health behaviors. Only optimism was positively associated with increases in psychosocial behaviors. Reports of positive change in physical and psychosocial behaviors were only modestly correlated. Social desirability was unrelated to reports of positive behavior change. Results are interpreted in light of theories of adaptation to cancer diagnosis and treatment. Copyright © 2006 John Wiley & Sons, Ltd.
Framing the onset of lung cancer biographically: narratives of continuity and disruption
Authors: Leveälahti Helena , Tishelman Carol , Öhlén Joakim 
Published: August 2006

AbstractMost patients are diagnosed with advanced lung cancer despite the presence of many and intense symptoms at diagnosis. This qualitative study aims to explore how people with inoperable lung cancer frame and conceptualize the onset of their sickness, to obtain knowledge which might facilitate earlier health care contact for people with potential lung cancer. Patients with inoperable lung cancer were recruited through a larger longitudinal study of 400 patients recruited consecutively from two university hospitals. The narrative analysis presented here is based on 91 narrative segments derived from audio‐taped and transcribed qualitative interviews with 37 patients who survived the first year post diagnosis, complemented with data from previous interviews with the same people. Findings indicate a wide array of bodily experiences leading to diagnosis, including symptoms seen as related to other disorders, systemic complaints not conceptualized as symptoms or indications of a serious problem, and more rarely, symptoms triggering immediate action. In addition to the ‘biographical disruption’ often associated with chronic illness, this analysis indicates an alternative or parallel process involving ‘biographical continuity’, allowing for integration of past and present aspects of patients' lives. Copyright © 2006 John Wiley & Sons, Ltd.
Feshbach shape resonance for high Tc superconductivity in superlattices of nanotubes
Authors: Bianconi Antonio 
Published: August 2006

AbstractThe case of a Feshbach shape resonance in the pairing mechanism for high T c superconductivity in a crystalline lattice of doped metallic nanotubes is described. The superlattice of doped metallic nanotubes provides a superconductor with a strongly asymmetric gap. The disparity and different spatial locations of the wave functions of electrons in different subbands at the Fermi level should suppress the single electron impurity interband scattering giving multiband superconductivity in the clean limit. The Feshbach resonances will arise from the component single‐particle wave functions out of which the electron pair wave function is constructed: pairs of wave functions which are time inverse of each other. The Feshbach shape resonance increases the critical temperature by tuning the chemical potential at the Lifshitz electronic topological transition (ETT) where the Fermi surface of one of the bands changes from the one dimensional (1D) to the two dimensional (2D) topology (1D/2D ETT). (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Wetting and layering transitions in magnetic films
Authors: Ez‐Zahraouy H. , Benyoussef A. , Bahmad L. 
Published: August 2006

AbstractThe understanding of the surface effect on wetting and layering transitions was explained both theoretically and experimentally. Indeed, using different spin system models and different numerical and approximate methods such as mean field and effective field theories, real space renormalization technique and Monte‐Carlo simulations, it is found that the wetting and layering transitions depend on the nature of the surface magnetic field, the surface coupling strength, the surface crystal field, the geometry of surface, the in‐homogeneity of substrate and the quantum fluctuations at the surface. It is also found that the layering transition temperature increases or decreases as a function of the film thickness depending on the surface coupling values. The wetting transition temperature can be greater or smaller than the layering temperature. In the case of a variable surface crystal field, an order‐disorder layering reentrance is found with new critical exponents behaviour. The wetting phenomena are also influenced by the nature of the surface. In fact the intra‐layer transitions appear under the effect of an edge on the surface and/or corrugated surfaces. However, the intra‐layering transitions are found for a surface temperature above, which the surface and the intra‐layer surface occur. While the bulk layering and intra‐layering transitions appear above another finite temperature which is greater than the former one. Such result is not found in the case of a perfect surface. Beside this, and under the corrugation effect, the pre‐wetting phenomena and layering transitions occur at zero temperature, even in the case of a uniform magnetic field. In this case the wetting temperature depends strongly on the width of the corrugated‐steps but weakly on its number. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A simplified protein precipitation/mixed‐mode cation‐exchange solid‐phase extraction, followed by high‐speed liquid chromatography/mass spectrometry, for the determination of a basic drug in human plasma
Authors: Xue Y.‐J. , Akinsanya J. Billy , Liu Jane , Unger Steve E. 
Published: August 2006

AbstractA simplified protein precipitation/mixed‐mode cation‐exchange solid‐phase extraction (PPT/SPE) procedure has been investigated. A mixture of acetonitrile and methanol along with formic acid was used to precipitate plasma proteins prior to selectively extracting the basic drug. After vortexing and centrifugation, the supernatants were directly loaded onto an unconditioned Oasis® MCX µElution 96‐well extraction plate, where the protonated drug was retained on the negatively charged sorbent while interfering neutral lipids, steroids or other endogenous materials were washed away. Normal wash steps were deemed unnecessary and not used before sample elution. The sample extracts were analyzed under both conventional and high‐speed liquid chromatography/tandem mass spectrometry (LC/MS/MS) conditions to examine the feasibility of the PPT/SPE procedure for human plasma sample clean‐up. For the conventional LC/MS/MS method, chromatographic separation was achieved on a C18, 2.1 × 50 mm column with gradient elution (k′ = 5.5). The mobile phase contained 0.1% formic acid in water and 0.1% formic acid in acetonitrile. For the high‐speed LC/MS/MS method, chromatographic separation was achieved on a C18, 2.1 × 10 mm guard column with gradient elution (k′ = 2.2, Rt = 0.26 min). The mobile phase contained 0.1% formic acid in water and 0.001% trifluoroacetic acid in acetonitrile. Detection for both conventional and high‐speed LC/MS/MS methods was by positive ion electrospray tandem mass spectrometry on a ThermoElectron Finnigan TSQ Quantum Ultra, where enhanced resolution (RP 2000; 0.2 amu) was used for high‐speed LC/MS/MS. The standard curve, ranging from 0.5 to 100 ng/mL, was fitted to a 1/x weighted quadratic regression model.This combined PPT/SPE procedure effectively eliminated time‐consuming sorbent conditioning and wash steps, which are essential for a conventional mixed‐mode SPE procedure, but retained the advantages of both PPT (removal of plasma proteins) and mixed‐mode SPE (analyte selectivity). The validation results demonstrated that this PPT/SPE procedure was well suited for both conventional and high‐speed LC/MS/MS analyses. In comparison with a conventional mixed‐mode SPE procedure, the simplified PPT/SPE process provided comparable sample extract purity. This simple sample clean‐up procedure can be applied to other basic compounds with minor modifications of PPT solvents. Copyright © 2006 John Wiley & Sons, Ltd.