bluuebunny/crossref_metadata_2025_split huggingface dataset:
“An Australian beauty-lover based in Singapore”: negotiating Asian Australian identity in the beauty vlogosphere
Authors: Dejmanee Tisha 
Published: April 2024

Abstract
This article explores how the conventions and culture of beauty vlogging elucidate Asian Australian identity and politics. Drawing on a qualitative analysis of Asian Australian beauty vlogger Tina Yong’s vlogs, I explore how national, ethnic, and racial identities are negotiated through platform logics, commercial imperatives, and community participation. Yong’s vlogs offer tangible ways to narrate the mundane, everyday experiences of Asian Australian identity that are underrepresented in mainstream Australian media. At the same time, Yong’s self-representation is made legible through her engagements with the commercialized beauty vlogosphere and her transnational audience, which tend to reduce the potential for illuminating hybrid and culturally specific Asian Australian experiences, communities, and politics. While Yong’s vlogs generate productive dialogue on race/ethnicity and race-based affinity communities, platform and commercial logics hinder her representational capacity as an Asian Australian subject who is doubly marginalized within the global beauty vlogosphere.
A Multivariate analysis on evoked components of Chinese semantic congruity: an OP-MEG study with EEG
Authors: Wu Huanqi , Liang Xiaoyu , Wang Ruonan , Ma Yuyu , Gao Yang , Ning Xiaolin 
Published: April 2024

Abstract
The application of wearable magnetoencephalography using optically-pumped magnetometers has drawn extensive attention in the field of neuroscience. Electroencephalogram system can cover the whole head and reflect the overall activity of a large number of neurons. The efficacy of optically-pumped magnetometer in detecting event-related components can be validated through electroencephalogram results. Multivariate pattern analysis is capable of tracking the evolution of neurocognitive processes over time. In this paper, we adopted a classical Chinese semantic congruity paradigm and separately collected electroencephalogram and optically-pumped magnetometer signals. Then, we verified the consistency of optically-pumped magnetometer and electroencephalogram in detecting N400 using mutual information index. Multivariate pattern analysis revealed the difference in decoding performance of these two modalities, which can be further validated by dynamic/stable coding analysis on the temporal generalization matrix. The results from searchlight analysis provided a neural basis for this dissimilarity at the magnetoencephalography source level and the electroencephalogram sensor level. This study opens a new avenue for investigating the brain’s coding patterns using wearable magnetoencephalography and reveals the differences in sensitivity between the two modalities in reflecting neuron representation patterns.
Pituitary volumes in patients with adjustment disorder
Authors: Atmaca Murad , Bibar Alper , Tabara Muhammed Fatih , Koc Mustafa , Gurok Mehmet Gurkan , Korkmaz Sevda , Mermi Osman , Yildirim Hanefi 
Published: April 2024

Abstract
The pituitary gland plays an important role in the stress response mechanism. Given the direct link between adjustment disorder and stress, we hypothesized that there might be changes in the pituitary gland in these patients. The study comprised a patient group of 19 individuals with adjustment disorder according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition, and 18 healthy controls. The mean pituitary gland volumes of the patient group were not statistically significantly different from those of the healthy control group (80.81 ± 1.82 mm3 in patients with adjustment disorder vs. 81.10 ± 7.04 mm3 in healthy controls, with a statistically nonsignificant difference of P &gt; 0.05). This finding is contrary to our previous findings in anxiety-related disorders. In this regard, adjustment disorder is not similar to anxiety-related disorders in terms of pituitary gland volumes. We should also clearly state that our study is a pioneering study and that studies with large samples are needed to support our findings. The limitations of our study can be attributed to the small sample size, the utilization of a cross-sectional design, and the inclusion of patients using psychotropic drugs.
Acute kidney injury and point-of-care ultrasound in liver cirrhosis: redefining hepatorenal syndrome
Authors: Banegas-Deras Eduardo Josué , Mazón-Ruiz Jaime , Romero-González Gregorio , Ruiz-Cobo Juan Carlos , Sanz-García Clara , Serrano-Soto Mara , Sánchez Emilio , Argaiz Eduardo R 
Published: April 2024

Abstract
Acute kidney injury (AKI) in patients with cirrhosis is a diagnostic challenge due to multiple and sometimes overlapping possible etiologies. Many times, diagnosis cannot be made based on case history, physical examination or laboratory data, especially when the nephrologist is faced with AKI with a hemodynamic basis, such as hepatorenal syndrome. In addition, the guidelines still include generalized recommendations regarding withdrawal of diuretics and plasma volume expansion with albumin for 48 h, which may be ineffective and counterproductive and may have iatrogenic effects, such as fluid overload and acute cardiogenic pulmonary edema. For this reason, the use of new tools, such as hemodynamic point-of-care ultrasound (PoCUS), allows us to phenotype volume status more accurately and ultimately guide medical treatment in a noninvasive, rapid and individualized manner.
Biological validation of faecal corticosterone metabolites as a non-invasive stress assessment in translocated California valley quail (Callipepla californica)
Authors: Currier Sarah A , Whitt Jeffrey G , Reyna Kelly S 
Published: April 2024

Abstract
US quail species are vulnerable to population declines as a result of climate change, habitat loss and habitat fragmentation, all of which can result in physiological stress. Additionally, population restoration techniques (PRTs), like translocations, also induce stress. Traditional assessments of avian stress hormone levels include capturing and handling birds to extract blood, methods that are inherently stressful and can compound stress analyses. However, the stress hormone corticosterone (CORT) is metabolized from the blood and excreted in faeces as faecal corticosterone metabolites (FCMs). FCMs have been used as a non-invasive measurement of stress hormone levels in a variety of species, but must be validated for each species. The objective of this study was to biologically validate the use of FCMs as a non-invasive measurement of CORT levels in California valley quail (Callipepla californica). Reference and treatment quail were acclimated for 3 weeks in an outdoor aviary. Subsequently, treatment quail were subjected to a simulated 48-h translocation, a common and stress hormone-inducing PRT. Faecal samples were collected every 4 h and processed using an enzyme immunoassay. Mean FCM concentrations of treatment quail (41.50 ± 16.13 ng/g) were higher than reference FCM concentrations (24.07 ± 10.4 ng/g). These results biologically validate the use of FCMs as a non-invasive method to assess CORT levels in California valley quail, demonstrate diurnal variation in quail CORT levels, and confirm that quail translocations are a stress-inducing PRT. Ultimately, this research validates a new non-invasive tool for stress response measurement to advance quail research, management and conservation.
Effectiveness and Persistency of Ustekinumab Treatment for Ulcerative Colitis: A Phoenix retrospective Cohort Study
Authors: Ando Katsuyoshi , Fujiya Mikihiro , Ueno Nobuhiro , Ito Takahiro , Maemoto Atsuo , Nasuno Masanao , Tanaka Hiroki , Sakurai Kensuke , Katsurada Takehiko , Orii Fumika , Ashida Toshifumi , Motoya Satoshi , Kazama Tomoe , Yokoyama Yoshihiro , Hirayama Daisuke , Nakase Hiroshi 
Published: April 2024

Abstract

Background
Real-world data regarding ustekinumab (UST) for ulcerative colitis (UC) particularly in biologics-naïve patients is currently limited. This study aimed to elucidate the real-world effectiveness and safety of UST for UC.

Methods
Overall, 150 patients with UC treated with UST from March 2020 to January 2023 were enrolled across 7 referral hospitals. To assess the clinical efficacy and persistence of UST, retrospective analyses were conducted from weeks 8 to 56. Predictive factors concerning the response and persistence of UST were examined through univariate and multivariate analyses.

Results
Of the 150 patients, 125 received UST for remission induction, including 36% biologics-naïve. The response and remission rates were 72.8% and 56.0% at week 8 and 73.2% and 63.4% at week 56, respectively. Biologics-naïve patients represented higher response and remission rates at week 8 (84.4% and 73.3%) than those with biologics exposure (66.2% and 46.2%). Patients with prior antitumor necrosis factor (anti-TNF) and vedolizumab (VDZ) exposure had relatively lower response and remission rates (34.5% and 24.1%, respectively). The 1-year cumulative persistence rate was 84.0%. Multivariate analysis revealed that the chronic continuous type and prior anti-TNF and VDZ exposure were negative predictive factors for week 8 responsiveness. Clinical response at week 8 was a predictor of 1-year persistence. Adverse event incidence remained notably low at 6.4%.

Conclusions
This study highlights the safety and effectiveness of UST as an induction and maintenance therapy for UC. Chronic continuous type and previous anti-TNF and VDZ exposure negatively contributed to short-term effectiveness, whereas short-term effectiveness provided good persistency.
CancerMHL: the database of integrating key DNA methylation, histone modifications and lncRNAs in cancer
Authors: Du Pengyu , Chen Yingli , Li Qianzhong , Gai Zhimin , Bai Hui , Zhang Luqiang , Liu Yuxian , Cao Yanni , Zhai Yuanyuan , Jin Wen 
Published: April 2024

Abstract
The discovery of key epigenetic modifications in cancer is of great significance for the study of disease biomarkers. Through the mining of epigenetic modification data relevant to cancer, some researches on epigenetic modifications are accumulating. In order to make it easier to integrate the effects of key epigenetic modifications on the related cancers, we established CancerMHL (http://www.positionprediction.cn/), which provide key DNA methylation, histone modifications and lncRNAs as well as the effect of these key epigenetic modifications on gene expression in several cancers. To facilitate data retrieval, CancerMHL offers flexible query options and filters, allowing users to access specific key epigenetic modifications according to their own needs. In addition, based on the epigenetic modification data, three online prediction tools had been offered in CancerMHL for users. CancerMHL will be a useful resource platform for further exploring novel and potential biomarkers and therapeutic targets in cancer.
Database URL: http://www.positionprediction.cn/
Efficacy and Safety of Etrasimod in Patients with Moderately to Severely Active Isolated Proctitis: Results From the Phase 3 ELEVATE UC Clinical Programme
Authors: Peyrin-Biroulet Laurent , Dubinsky Marla C , Sands Bruce E , Panés Julian , Schreiber Stefan , Reinisch Walter , Feagan Brian G , Danese Silvio , Yarur Andres J , D’Haens Geert R , Goetsch Martina , Wosik Karolina , Keating Michael , Lazin Krisztina , Wu Joseph , Modesto Irene , McDonnell Aoibhinn , Bartolome Lauren , Vermeire Séverine 
Published: April 2024

Abstract

Background and Aims
Pivotal trials in ulcerative colitis have historically excluded patients with isolated proctitis. Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis. This post hoc analysis assessed efficacy and safety of etrasimod 2 mg once daily in patients with isolated proctitis (centrally read) from the phase 3 ELEVATE UC 52 and ELEVATE UC 12 trials.

Methods
Patients, including those with isolated proctitis (&lt;10 cm rectal involvement) who met all other inclusion criteria in ELEVATE UC 52 and ELEVATE UC 12, were randomised 2:1 to receive etrasimod or placebo. Primary, secondary and other identified efficacy endpoints and safety were assessed.

Results
We analysed data from 64 and 723 patients at Week 12 (both trials pooled), and 36 and 397 patients at Week 52 (ELEVATE UC 52 only) with isolated proctitis and more extensive colitis (≥10 cm rectal involvement), respectively. Patients with isolated proctitis receiving etrasimod demonstrated significant improvements versus placebo, including clinical remission rates at Weeks 12 (42.9% vs 13.6%) and 52 (44.4% vs 11.1%), endoscopic improvement (52.4% vs 22.7%) at Week 12 and bowel urgency numerical rating scale score at Week 12 (all p &lt; 0.01). Generally similar trends were observed in patients with more extensive colitis. Safety was consistent across subgroups, with no new findings.

Conclusions
Etrasimod demonstrated significant improvements versus placebo in patients with isolated proctitis, and those with more extensive disease, in most efficacy endpoints at Week 12 and 52.
Clinicaltrials.gov: NCT03945188; NCT03996369
Concordant B and T Cell Heterogeneity Inferred from the multi-omic Landscape of Peripheral Blood Mononuclear Cells in a Crohn’s Disease Cohort
Authors: Brown Margaret , Dodd Anne , Shi Fang , Greenwood Emily , Nagpal Sini , Kolachala Vasantha L , Kugathasan Subra , Gibson Greg 
Published: April 2024

Abstract

Background and Aims
Crohn’s disease is characterised by inflammation in the gastrointestinal tract due to a combination of genetic, immune, and environmental factors. Transcriptomic and epigenomic profiling of intestinal tissue of Crohn’s disease patients have revealed valuable insights into pathology, but have not been conducted jointly on less invasive peripheral blood mononuclear cells [PBMCs]. Furthermore, the heterogeneous responses to treatments among individuals with Crohn’s disease imply hidden diversity of pathological mechanisms.

Methods
We employed single nucleus multi-omic analysis, integrating both snRNA-seq and snATAC-seq of PBMCs with a variety of open source, bioinformatics applications.

Results
Our findings reveal a diverse range of transcriptional signatures among individuals, highlighting the heterogeneity in PBMC profiles. Nevertheless, striking concordance between three heterogeneous groups was observed across B cells and T cells. Differential gene regulatory mechanisms partially explain these profiles, notably including a signature involving TGFß signalling in two individuals with Crohn’s disease. A mutation mapped to a transcription factor binding site within a differentially accessible peak associated with the expression of this pathway, with implications for a personalised approach to understanding disease pathology.

Conclusions
This study highlights how multi-omic analysis can reveal common regulatory mechanisms that underlie heterogeneity of PBMC profiles, one of which may be specific to inflammatory disease.
A case report of successful primary percutaneous coronary intervention to an occluded anomalous left main coronary artery arising from the right coronary sinus
Authors: Wong Christopher C Y , Pogatchnik Brian P , Clark Daniel E , Sharma Rahul P 
Published: April 2024

Abstract

Background
Anomalous aortic origin of a coronary artery from the opposite sinus is a rare congenital abnormality that may be encountered during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI).

Case summary
A 65-year-old man presented with chest pain and signs of heart failure. Electrocardiogram demonstrated atrial fibrillation with ST elevation in the high lateral leads, and he was taken emergently to the cardiac catheterization laboratory for primary PCI. Coronary angiography identified the culprit to be an occluded anomalous left main coronary artery (LMCA) arising from the right coronary cusp, and primary PCI was successfully performed in the LMCA and the left anterior descending artery (LAD). Computed tomography angiography confirmed a benign retroaortic course of the anomalous LMCA with no additional high-risk features, as well as a new left atrial appendage thrombus. He subsequently developed deep venous thrombosis, acute pulmonary embolism, and acute kidney injury secondary to renal artery embolism with associated infarction. Workup for patent foramen ovale and thrombophilia were negative, and he was discharged in a stable condition. At 2-month follow-up, he was asymptomatic with no evidence of myocardial ischaemia on stress cardiac magnetic resonance imaging.

Discussion
We present the first reported case of an occluded anomalous LMCA arising from the right coronary sinus in a patient presenting with STEMI. Rapid recognition of this congenital anomaly and selection of an appropriate guide catheter were keys to achieving timely reperfusion and a good outcome in this case.
Cohort profile: the European Unified Registries On Heart Care Evaluation and Randomized Trials (EuroHeart)—acute coronary syndrome and percutaneous coronary intervention
Authors: Bhatty Asad , Wilkinson Chris , Batra Gorav , Alfredsson Joakim , Erlinge David , Ferreira Jorge , Guðmundsdóttir Ingibjörg J , Hrafnkelsdóttir þórdís Jóna , Ingimarsdóttir Inga Jóna , Irs Alar , Járai Zoltán , Jánosi András , Popescu Bogdan A , Santos Manuel , Vasko Peter , Vinereanu Dragos , Yap Jonathan , Maggioni Aldo P , Wallentin Lars , Casadei Barabara , Gale Chris P 
Published: April 2024

Abstract

Aims
The European Unified Registries On Heart Care Evaluation and Randomized Trials (EuroHeart) aims to improve the quality of care and clinical outcomes for patients with cardiovascular disease. The collaboration of acute coronary syndrome/percutaneous coronary intervention (ACS/PCI) registries is operational in seven vanguard European Society of Cardiology member countries.

Methods and results
Adults admitted to hospitals with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) are included, and individual patient-level data collected and aligned according to the internationally agreed EuroHeart data standards for ACS/PCI. The registries provide up to 155 variables spanning patient demographics and clinical characteristics, in-hospital care, in-hospital outcomes, and discharge medications. After performing statistical analyses on patient data, participating countries transfer aggregated data to EuroHeart for international reporting. Between 1st January 2022 and 31st December 2022, 40 021 admissions (STEMI 46.7%, NSTEMI 53.3%) were recorded from 192 hospitals in the seven vanguard countries: Estonia, Hungary, Iceland, Portugal, Romania, Singapore, and Sweden. The mean age for the cohort was 67.9 (standard deviation 12.6) years, and it included 12 628 (31.6%) women.

Conclusion
The EuroHeart collaboration of ACS/PCI registries prospectively collects and analyses individual data for ACS and PCI at a national level, after which aggregated results are transferred to the EuroHeart Data Science Centre. The collaboration will expand to other countries and provide continuous insights into the provision of clinical care and outcomes for patients with ACS and undergoing PCI. It will serve as a unique international platform for quality improvement, observational research, and registry-based clinical trials.
Multilayer anisotropy along the Alaska-Aleutians Subduction zone
Authors: Birkey Andrew , Lynner Colton 
Published: April 2024

SUMMARY
Increasing evidence from seismic methods shows that anisotropy within subduction zones should consist of multiple layers. To test this, we calculate and model shear wave splitting across the Alaska-Aleutians Subduction Zone (AASZ), where previous studies have argued for separate layers of anisotropy in the subslab, slab and mantle wedge. We present an updated teleseismic splitting catalogue along the span of the AASZ, which has many broad-band seismometers recently upgraded to three components. Splitting observations are sparse in the Western Aleutians, and fast directions are oriented generally trench parallel. There are significantly more splitting measurements further east along the AASZ. We identify six regions in the Central and Eastern Aleutians, Alaskan Peninsula and Cook Inlet with a high density of splits suitable for multilayered anisotropy analyses. These regions were tested for multilayer anisotropy, and for five of the six regions we favour multiple layers over a single layer of anisotropy. We find that the optimal setup for our models is one with a dipping middle layer oriented parallel to palaeospreading. A prominent feature of our modelling is that fast directions above and below the dipping layer are generally oriented parallel to the strike of the slab. Additionally, we lay out a framework for robust and statistically reliable multilayer shear wave splitting modelling.
Targeting belongingness among older people through engagement in senior centres: intervention development study in Denmark
Authors: Langergaard Sofie , Evans Rhiannon , Andreasen Jane , Petersen Kirsten Schultz , Overgaard Charlotte 
Published: April 2024

Abstract
Adults often experience a loss of social relations and sense of belonging in later life, leading to the risk of social isolation. Municipal senior centres offer a potential site for intervention, as they provide social communities targeting older people. However, not all older people find it easy to access these social communities due to experiencing physical and/or psychosocial frailties and could therefore continue to experience a decline in social relations and sense of belonging, which potentiates poor physical and psychosocial health and well-being. To date, there are limited evidence-based interventions in Denmark. The present article describes the development of an intervention to increase belongingness and decrease social isolation among older people with frailties who attend Danish municipal senior centres. The development process was conducted with reference to the INDEX (IdentifyiNg and assessing different approaches to DEveloping compleX intervention) guidance. The development process resulted in a 6-month supportive intervention, consisting of four elements: skills development workshops for all staff members; a start conversation including frailty screening; allocation of a ‘buddy’ among existing service users; and monthly follow-up conversations with staff members. This theory-informed approach can progress to feasibility testing and outcome evaluation in order to generate an evidence base. Concurrently, the article reflects on current guidance for intervention development and how it may be used and optimized to strengthen developmental processes in the future.
Watching the sunrise on our ocean planet in a new era of marine science
Authors: Schofield Oscar 
Published: April 2024

Abstract
Over the last 30 years, ocean sciences have been undergoing a technological revolution. Changes include the transition of autonomous platforms from being interesting engineering projects to being critical tools for scientists studying a range of processes at sea. My career has benefitted immensely from these technical innovations, allowing me to be at sea (virtually) 365 days a year and operate ocean networks globally. While these technical innovations have opened many research doors, many aspects of oceanography are unchanged. In my experience, working/talking/scheming with scientists is most effective face-to-face. Despite the growing capabilities of robotic platforms, we will still need to go to sea on ships to conduct critical experiments. As the responsibilities of scientists expand with mandated outreach efforts, I strongly urge young scientists to leverage the expertise of Broader Impact professionals, who are increasingly available to our community, in order to maximize the effectiveness and efficiency of our outreach efforts. Given the increasing observations of change occurring in the ocean, our work is ever-more important while still being fun. I am blessed to have had a career as an oceanographer exploring this planet.