bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photocatalytic Degradation of Ampicillin Under Sunlight Using a Boron Cerium and Silver Ternary Doped Titanium Dioxide Catalyst Synthesized via the EDTA-Citrate Method
Authors: Mishra Yash , Mahalingam Hari 
Published: February 2025

Abstract

Nowadays, we can see that in river water, traces of antibiotics can be found, which is an emerging problem. Also, pharmaceutical companies' wastewater contains antibiotic traces present in it in a significant amount which makes it an excellent experimental domain to work upon. Which is very harmful if taken by humans without its treatment, so to treat it as early as possible is very necessary, else the bacteria emerging in that water will be converted to superbugs and then curing the disease from that bacteria will be exceedingly difficult as they have resistive power to that antibiotic. For that, we have prepared a tri-doped photocatalyst by doping boron cerium and silver in a titanium dioxide structure. It can work under sunlight light because the presence of silver in this boron amount is increased so that it can satisfactorily degrade antibiotics. Cerium is for water disinfection in the further catalyst. Its amount was also increased. Then the characterization analysis was performed with the help of DLS analysis with the help of a nanoparticle size analyzer, and we got particle size in the range of 115 to 600 nanometer XRD analysis. We got a band gap Of 2.3 to 2.4 electron Volt.BET surface area analysis showed us a surface area of about 25 m2/g.So instead of the UVA lights now, it was performed under the sunlight and the degradation percent was increased significantly to approx 70 percent.
Sibling Influence on Childhood Neurodevelopmental Disorders: A Cohort Study in Taiwan
Authors: Su Yi-Yu , Chen Chi-Jen , Chen Mei-Huei , Lin Ching-Chun , Hsieh Wu-Shiun , Chiou Hung-Yi , Chang Hsi , Yen Chiung-Hui , Chen Pau-Chung 
Published: February 2025

Abstract

Purpose
Autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and cerebral palsy (CP) are neurodevelopmental disorders that impose lasting burdens on families. Birth order and sibling presence may influence neurodevelopmental risks, providing critical insights for early intervention and public health policies.
Method
This study analyzed 2,045,178 children from Taiwan’s Birth Registration Database (2004–2014), linked to National Health and Death Registries through 2020. Children were categorized by sibling status (single child, first-born, second-born, third-or-later-born) to examine birth order effects on CP, developmental delay, ASD, and ADHD. Kaplan-Meier and Cox proportional hazards models were used, accounting for birth outcomes, socioeconomic status, and urbanization.
Results
Children with siblings had lower neurodevelopmental disorder risks than single children. ASD and ADHD risks declined with increasing birth order, while first-born siblings had higher risks of ADHD and developmental delay compared to later-born children. Subgroup analyses consistently showed that sibling presence was associated with reduced risks.
Conclusion
Birth order and sibling presence influence neurodevelopmental disorder risks, with single children at higher risk. These findings are particularly relevant given declining birth rates in developed countries and highlight the need for targeted screening and intervention strategies for high-risk groups.
Age-related differences in cerebellar gene expression in autism spectrum disorder development
Authors: Marui Tetsuya , Sugano Sumio 
Published: February 2025

Abstract

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that typically manifests in early infancy. Previous gene expression studies using cerebral cortex tissues from individuals with ASD have identified several differences relative to neurotypical controls. However, transcriptome studies of the cerebellum in ASD are limited, primarily due to the lack of significant differential gene expression (DGE), and the specific genes involved remain unclear.
In this study, we examined gene expression differences in cerebellar tissues using RNA sequencing between individuals with ASD and neurotypical controls, stratified by age. We also investigated alternative splicing events by analysing mRNA isoform expression patterns in both age groups. The study included participants aged 4–16 years (seven ASD vs. seven controls) and participants aged 19–46 years (seven ASD vs. seven controls).
Our results reveal significant differences in both mRNA expression and mRNA isoforms between ASD and control cerebellar tissues in each age group, after correction for multiple comparisons. Genes associated with ASD differed between the two age groups, and changes in isoform expression also varied with age.
Although gene expression in the cerebellum has not been a primary focus of ASD research, our study demonstrated that significant differences can be observed when participants are stratified by age. This study is the first to suggest that the cerebellum is an important target for gene expression studies in ASD. Our findings further indicate that distinct genes are involved at different developmental stages of ASD, highlighting the importance of age stratification in future transcriptome studies.
Projeto de extensão universitária: uma abordagem lúdica envolvendo a biotecnologia para alunos de escola de ensino fundamental em Belém – PA
Authors: SILVA João Pedro Pinheiro , RODRIGUES Natalia de Paula , OLIVEIRA Sara Cristine Farias de , GAMA Wellygton Lopes da , SILVA Jéssica Saldanha , OLIVEIRA Herica Santos de , SOUZA Joanne Moraes de Melo 
Published: February 2025

As universidades têm um papel crucial em proporcionar vivências imprescindíveis aos discentes através do conhecimento pluridisciplinar, no qual terão o dever de compartilhar seus feitos e experiências adquiridas com a comunidade, de acordo com a Lei Federal de Diretrizes e Bases da Educação. Dessa forma, executou-se um evento de extensão com os discentes da UFRA, denominado I Mostra de Biotecnologia Vegetal que teve o intuito de compartilhar o conhecimento da biotecnologia vegetal, micropropagação de plantas com alunos do 1° ao 4° ano de escolas de Belém/PA, com a finalidade de estimular o interesse e divulgar o conhecimento na área , de forma lúdica, utilizado ferramentas como banner, jogo da memória, quebra cabeça, quiz e plântulas in vitro. O conhecimento prévio dos alunos em relação aos temas da biotecnologia eram muito escassos. A abordagem lúdica aplicada nas escolas de ensino fundamental mostrou ser eficiente, contribuindo para a aprendizagem acerca da biotecnologia vegetal.
Insights into kinetic and regression models developed to estimate the abundance of antibiotic-resistant genes during biological digestion of wastewater sludge
Authors: Poorasgari Eskandar , Örmeci Banu 
Published: February 2025

ABSTRACT

Wastewater treatment plants are hubs of antibiotic-resistant genes (ARGs). During wastewater treatment, ARGs accumulate in wastewater sludge and some survive biological digestion. After land application of digested sludge, ARGs are transported to soil, water, and air, and may encounter humans and animals. ARGs are typically quantified by quantitative polymerase chain reaction (qPCR) on isolated DNA. Nevertheless, DNA isolation and qPCR are time-consuming, expensive, and prone to contamination. Therefore, there is a need to estimate ARGs quantities via methods that can be readily employed. Such estimation would help to protect public health via modifying biological digestion to maximize the removal of ARGs. Two approaches that make such estimation are kinetic and regression modeling. The kinetic models have been mainly of the first order. This review examines the application of the kinetic models to estimate the abundance of ARGs during biological sludge digestion. It also discusses how biological sludge digesters can be designed using kinetic models. The literature provides single and multiple regression models, from which an ARGs -Solids -Nutrients nexus, a focal point of this review, is inferred. This review demonstrates that regression models are mathematical expressions of that nexus. Also, existing challenges are highlighted and suggestions for future are provided.
Enhancing water quality prediction: a machine learning approach across diverse water environments
Authors: Peerzade Sabanaz , Kamat Pooja 
Published: February 2025

ABSTRACT

Rapid urbanization and industrialization have significantly contributed to the pollution and degradation of water bodies through urban runoff, industrial discharge, and inadequate wastewater treatment infrastructure. This study explores the role of machine learning (ML) as a decision-support tool for addressing water quality challenges across diverse environments, including surface water, groundwater, seawater, and wastewater. We evaluated the performance of seven ML models for predicting water quality parameters using data from six years (2014–2019) of the Melbourne Eastern wastewater treatment plant, encompassing energy consumption, climate variables, and wastewater characteristics. Among the models tested, the gradient boosting model demonstrated the highest predictive accuracy, achieving a statistical measure coefficient of determination R2 score of 0.75. Key findings highlight the importance of integrating climate and water quality data to improve prediction accuracy and identify critical water parameters for enhancing future models. This review provides insights into the applicability of ML techniques in water quality management and identifies potential avenues for further research in predictive modeling.
Efektivitas Model Pembelajaran Three Minutes Review (TMR) Berbantuan Flipbook Dilengkapi LKPD Interaktif Liveworksheets Terhadap Hasil Belajar Siswa SMA N 2 Waingapu
Authors: Dimu Mia Fransiska , Tamu Ina Anita , Makatita Audrey Louise 
Published: February 2025

The purpose of this study was to determine how the effect of the TMR model assisted by flipbook and liveworksheets LKPD liveworksheets on student learning outcomes at SMA Negeri 2 Waingapu. Student learning outcomes are low because the teacher has never tried to vary never tried to vary other learning models and media used during the learning process used during the learning process. This research is a quantitative research with an experimental approach and random sampling. Samples used in this study were used in this study were class XI IPA 1 as the experimental class, totaling 33 people and class XI IPA 3 as the control class, totaling 33 people. Which amounted to 33 people and class XI IPA 3 as a control class which amounted to 67 people. 34 total sample size of 67 people. The results of the research average pretest score the control class was 49.09 and the average posttest score was 66.66. While for the experimental class the average pretest score was 59.11 and the average posttest score was 72.35. posttest score is 72.35. With an asym sig (2-tailed) value of 0.001 <0.05, the hypothesis test shows that the TMR learning model that is used in the experimental class is more effective than the control class. Hypothesis test shows that the TMR learning model assisted by the flipbook and LKPD liveworkshseets have an effect on student learning outcomes students.
Abstrak. Tujuan penelitian ini adalah untuk mengevaluasi bagaimana model TMR yang dibantu oleh mdeia flipbook dan LKPD liveworkhseets berpengaruh pada hasil belajar siswa di SMA Negeri 2 Waingapu. Hal ini disebabkan karena guru tidak pernah mencoba memvariasikan model pembelajaran lain serta media, yang berdampak pada hasil belajar siswa yang rendah. Penelitian ini merupakan kuantitatif dengan pendekatan eksperimen dan pengambilan sampel secara acak. Kelas XI IPA 1 dan XI IPA 3 berfungsi sebagai kelas eksperimen dan kontrol. Hasil menunjukkan nilai pretest dan postest untuk kelas eksperimen 59,11 dan 72,35, sementara nilai kelas kontrol 49,09 dan 66,66. Dengan nilai asym sig. (2-tailed) 0,001<0,05, uji hipotesis menunjukkan bahwa model pembelajaran TMR yang dibantu flipbook dan loveworkhseets LKPD memengaruhi hasil belajar.
Kelayakan Biocard Pada Submateri Pemanfaatan Keanekaragaman Hayati Indonesia Kelas X SMA
Authors: Maryulini Mareta , Syamswisna Syamswisna , Afandi Afandi 
Published: February 2025

This research aims to measure the feasibility of biocard media in learning the Use of Biodiversity in Indonesia Class X. This research was conducted in the form of qualitative research using descriptive methods. Samples were taken using purposive sampling technique. The research results were implemented into biocard media. The results of data analysis used the Lawshe (1975) method. Biocard media was validated by 5 validators consisting of 2 Biology Education lecturers at FKIP Tanjungpura University and three Biology teachers from SMAN 1 Lumar, SMAN 1 Bengkayang, and SMAN 2 Bengkayang. Based on the average results of the CVR values from 11 criteria, a CVI value of 0.96 was obtained in the valid category, so it can be concluded that the biocard learning media on biodiversity material is suitable for use in the learning process as a learning medium.
Abstrak. Penelitian ini bertujuan untuk mengukur kelayakan media biocard pada sub materi Pemanfaatan Keanekaragaman Hayati Indonesia Kelas X terhadap manfaat tumbuhan obat oleh masyarakat dusun Madi. Penelitian ini dilakukan dalam bentuk penelitian kualitatif dengan menggunakan metode deskriptif. Sampel diambil dengan menggunakan teknik purposive sampling. Berdasarkan analisis silabus, hasil penelitian diimplementasikan ke dalam media biocard. Biocard diuji dengan lima validator dengan menggunakan skala Likert dan dianalisis dengan menggunakan metode Lawshe (1975). Dua orang dosen Prodi Pendidikan Biologi FKIP UNTAN dan tiga orang guru Biologi dari SMAN 1 Lumar, SMAN 1 Bengkayang, dan SMAN 2 Bengkayang mengikuti uji kelayakan media. Media biocard memperoleh skor Content Validity Index (CVI) sebesar 0,96 dari lima validator dengan kategori valid dan layak digunakan pada sub materi Pemanfaatan Keanekaragaman Hayati Indonesia, namun masih perlu diujicobakan ke dalam kelas
Kata kunci: keanekaragaman hayati, Kelayakan, validasi bahan ajar media biocard.
Respon Mahasiswa Terhadap Modul Sistem Peredaran Darah Pada Manusia Berbasis Flipbook
Authors: Frisillia Unikhe , Sianturi Stephanie Agustin , Tarigan Cania Yekholia , Witin Theresia Adhellia , Afdhannisa Daffa , Rosmanta Aritonang Frince Winda , Silitonga Melva 
Published: February 2025

This study aims to determine how students respond to the use of flipbook modules in Human Anatomy and Physiology courses on the material of the human circulatory system. Flipbook-based modules use animation, sound, and images to communicate information dynamically that increases student engagement and understanding. This study involved 50 Biology Department students from the 2022 batch. A 4-point Likert-based questionnaire was used to collect data, and the questionnaire contained questions about the clarity of the module's objectives, understanding of the content, attractiveness, and learning independence. The results showed that 79% of students found the module material easy to understand, and 76% found it interesting and interactive. Although this module is effective overall, there are several things that need to be considered, including the way the content is delivered and elements that encourage students to learn independently. Therefore, the flipbook module has proven to be practical for use in education, although it still needs improvement to get better results.
Absrtak. Penelitian ini bertujuan untuk mengetahui bagaimana respon mahasiswa terhadap penggunaan modul flipbook dalam mata kuliah Anatomi dan Fisiologi Manusia pada materi sistem peredaran darah pada manusia. Modul berbasis flipbook menggunakan animasi, suara, dan gambar untuk mengomunikasikan informasi secara dinamis yang meningkatkan keterlibatan dan pemahaman mahasiswa. Penelitian ini melibatkan 50 mahasiswa Jurusan Biologi dari stambuk 2022. Kuesioner berbasis Likert 4 poin digunakan untuk mengumpulkan data, dan kuesioner tersebut berisi pertanyaan tentang kejelasan tujuan modul, pemahaman konten, daya tarik, dan kemandirian belajar. Hasil penelitian menunjukkan bahwa 79% mahasiswa menganggap materi modul mudah dipahami, dan 76% menganggapnya menarik dan interaktif. Meskipun modul ini secara keseluruhan efektif, ada beberapa hal yang perlu diperhatikan, termasuk cara penyampaian konten dan elemen yang mendorong siswa untuk belajar secara mandiri. Oleh karena itu, modul flipbook terbukti praktis untuk digunakan dalam pendidikan, meskipun masih perlu penyempurnaan untuk mendapatkan hasil yang lebih baik.
Importance of the early phase of orthodontic force application in the induction of root resorption
Authors: Funaki-Dohi Mariko , Hotokezaka Yuka , Hotokezaka Hitoshi , Nashiro-Oyakawa Yukako , Moriishi Takeshi , Ohama Mizuki , Iuchi Yosuke , Nakamura Takuya , Nishioka-Sakamoto Kie , Yoshida Noriaki 
Published: February 2025

ABSTRACT

Objective
To investigate the effectiveness of early and short-term administration of lithium (Li) during orthodontic force application (OFA) in preventing orthodontically induced root resorption (OIRR) and verify the importance of the early phase of OFA in the induction of OIRR.

Materials and Methods
Bilateral maxillary first molars of 10-week-old male Wistar rats were moved for 14 days using a closed coil spring inserted between the first molar and the incisor. The rats were randomly grouped into three groups: a group receiving Li for the first 4 days, a group receiving Li daily for 14 days, and a control group receiving a vehicle (saline). Orthodontic tooth movement (OTM) was measured using microcomputed tomography on day 14. The OIRR, osteoclasts, and odontoclasts were evaluated via histological analysis. Immunohistochemical staining for the receptor-activated NF-kB ligand and osteoprotegerin was also performed.

Results
The OTM distance did not differ among the three groups, and the pattern of OTM changed from tipping to bodily movement for both Li groups. Early and short-term administration of Li suppressed OIRR on day 14 as effectively as long-term administration for 14 days. The observed odontoclasts on days 4 and 14 were significantly reduced in both Li groups. Osteoprotegerin expression was significantly increased on day 14 in both groups receiving Li relative to the vehicle group.

Conclusions
Early and short-term Li administration effectively suppressed OIRR. This suggests that the early phase of OFA plays an important role in the induction of OIRR.
Penanaman Nilai Nasionalisme dan Patriotisme melalui Pendidikan dan Kegiatan Lomba Harijadi Kemerdekaan RI bagi Anak Pekerja Migran Sanggar Bimbingan Kuala Lumpur Malaysia
Authors: Handayani Fitri , Sua Andi Tenri , Adriana Putri , Jafar Muhammad , Suwarni Andi , Dian Dian , Said Riani , Herawati Shabrina , Purnomo Eko 
Published: February 2025

Nasionalisme adalah paham kebangsaan, yang berarti seseorang yang mempunyai rasa cinta kepada tanah airnya dan cinta terhadap bangsanya sendiri. Pemahaman akan pentingnya menumbuhkan cinta pada tanah air perlu disadari oleh semua pihak yang terlibat dalam proses pendidikan anak usia dini, terutama bagi siswa Sanggar Bimbingan Kuala Lumpur, Malaysia. Tujuannya tak lain adalah membekali mereka dengan nilai-nilai nasionalisme dan patriotisme sebagai generasi yang akan membawa bendera Indonesia di masa depan, terutama dalam konteks global. Salah satu masalah penting yang dihadapi adalah kurangnya rasa nasionalisme yang ditanamkan pada jati diri anak-anak, kurangnya kewarganegaraan anak menghalangi mereka untuk memiliki akses terhadap hak-hak dasar lainnya termasuk hak atas bantuan sosial, hak atas pekerjaan, hak atas kesehatan, hak atas penghidupan yang layak, dan hak atas pendidikan Untuk mendapatkan pemahaman yang mendalam tentang masalah yang diteliti, pendekatan pengabdian yang digunakan adalah pendekatan deskriptif dengan jenis data kualitatif untuk menanamkan nilai-nilai nasionalisme terhadap anak-anak migran Indonesia. Adapun tujuan dari pengabdian ini adalah untuk menanamkan rasa nasionalisme pada anak-anak pekerjaan migran Indonesia melalui pendidikan dan perayaan 17 Agustus di Sanggar Bimbingan Kuala Lumpur, Malaysia. Berdasarkan hasil pengabdian ini, dapat disimpulkan bahwa program pembelajaran PPKN (Pendidikan Kewarganegaraan), pengadaan lomba dan upacara 17 Agustus serta nonton film sejarah 10 november 1945 dengan media audio visual dan peraktik langsung dapat bermanfaat bagi anak-anak migran di Malaysia.
Peningkatan Kemampuan Berbahasa Arab dan Inggris berpendekatan Sosiopragmatik bagi Siswa SMK Muhammadiyah Lampung
Authors: Prayitno Harun Joko , Purnomo Eko , Kurniaji Ganno Tribuana , Pradana Fajar Gemilang , Al Sanaani Ali Essam , Taha Ali Abdulraoof , Sya’adah Himatus , Putra Romi Iriandi 
Published: February 2025

Kemampuan bahasa Arab dan bahasa Inggris merupakan hal yang penting dalam era kemajuan digital. Kedua bahasa tersebut merupakan bahasa internasional yang banyak digunakan diberbagai dunia. Pengabdian ini bertujuan untuk meningkatkan kemampuan berbahasa Arab dan Inggris pada siswa SMK Muhammadiyah Lampung. Metode yang digunakan dalam pengabdian ini adalah metode partisipasi aktif. Hasil pengabdian menunjukkan bahwa dengan menghadirkan native speaker yang berasal dari Yaman dapat meningkatkan pemahaman siswa dalam melakukan komunikasi dasar bahasa Arab dan bahasa Inggris. Hal ini ditunjukkan dengan peningkatan kosakata para siswa dalam bahasa Arab yang memiliki skor rata-rata siswa meningkat dari 45 menjadi 72 (skala 100), sedangkan untuk bahasa Inggris, peningkatan skor rata-rata adalah dari 50 menjadi 78 (dalam skala 100). Selain itu, kosakata mereka naik terbukti siswa mampu mengenali dan menggunakan sekitar 50 kosakata dasar dalam bahasa Arab dan 60 kosakata dasar dalam bahasa Inggris. Pengabdian ini memberikan dampak yang signifikan bagi perkembangan bahasa asing siswa SMK Muhammadiyah Lampung. Harapannya pengabdian ini tidak hanya sampai di sini saja, namun dapat berkembang melalui berbagai kegiatan yang serupa dan memiliki dampak yang signifikan pula.