bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Study of Systemic Lupus Erythematosus
Authors: Lowenstein Mitchell B. , Rothfield Naomi F. 
Published: February 2007

AbstractThe clinical history, deposition of IgG, IgM, IgA, C3, C4, and properdin at the dermal‐epidermal junction (DEJ) of clinically normal skin, serum ANA, DNA‐binding, C3, C4, Factor B, and properdin were compared in 27 systemic lupus erythematosus (SLE) probands, 21 first‐degree household contact relatives (FDHCR), 19 first‐degree nonhousehold contact relatives (FDNHCR), 15 spouses, 26 controls, and 16 chronic discoid lupus erythematosus patients. Female consanguineous relatives of SLE patients had a higher incidence of rheumatic symptoms than male relatives (P < 0.01). Female FDHCR and male spouses had a higher incidence of protein deposition at the DEJ than sex‐matched controls (P = 0.026 and 0.0028). The incidence of protein deposition at the DEJ in FDNHCR did not differ from sex‐matched controls. ANA titers of the consanguineous relatives were significantly higher than those of the spouses or sex‐matched controls irrespective of household contact with their proband. The observation of protein deposition at the DEJ in normal appearing skin of FDHCR and spouses suggests the importance of environmental factors, whereas the elevations of ANA titers in consanguineous relatives suggests the importance of genetic factors in the pathogenesis of SLE.
The Activating Effect of Synovial Fluid and Washings of Synovial Membrane on Autologous Lymphocytes in Rheumatoid Arthritis
Authors: Sebŉk J. , Talerman A. , Wouters H. W. , Lems P. H. 
Published: February 2007

AbstractThe effect of synovial fluid and washings of synovial membrane on autologous lymphocytes from patients with rheumatoid arthritis and other diseases has been studied using a rapid method based upon the increase in intranuclear birefringence occurring in the early stages of lymphocyte activation. Retardation of polarized light indicating increased lymphocyte activation was seen in lymphocytes from patients with rheumatoid arthritis but not in lymphocytes from patients with other diseases.
Polyclonal Hyperviscosity Syndrome
Authors: Hadler Nortin M. , Gabriel Don , Chung K. Su , Teague Patricia , Napier Mary A. 
Published: February 2007

AbstractThe clinical course of two patients who presented with polyclonal hyperviscosity syndrome is described. Polymerizing IgG rheumatoid factors were isolated from the serum of both patients. The presence of these polymers with their extraordinary rheologic properties was the principal determinant of the abnormal rheological properties of the plasma. Neither patient had a discrete rheumatic disease. In both, a lymphoproliferative syndrome was present with features suggestive of the “pseudolymphoma” of Sjögren's syndrome.
Circulating immune complexes and antinuclear antibodies in juvenile rheumatoid arthritis
Authors: Rossen R. D. , Brewer E. J. , Person D. A. , Templeton J. W. , Lidsky M. D. 
Published: February 2007

AbstractMaterials with the Clq binding properties of soluble immune complexes (IC) were found in sera from 11 of 51 consecutive (22%) children with juvenile rheumatoid arthritis (JRA) and in 17 of 20 adults with active sero‐positive rheumatoid arthritis (RA). IC appeared more frequently in children with systemic onset disease whereas antinuclear antibody (ANA) was found more frequently in sera from those with pauciarticular disease. Only 3 JRA sera contained anti‐immunoglobulin (rheumatoid factor); those 3 also had high Clq binding activities. Seven of 50 patients (14%) carried HLA‐B27 but B27 was not associated with high Clq binding activity or presence of ANA. The presence of free ANA more frequently in children with mild disease and IC more frequently in children with relatively severe disease suggests that children with systemic JRA may have a relative defect in antibody‐forming capacity or reticuloendothelial function which results in decreased clearance of circulating IC. Alternatively, systemic, polyarticular, and pauciarticular JRA may represent a spectrum of clinically similar diseases resulting from different etiologic agents.
Adjuvant polyarthritis
Authors: Chang Yi‐Han , Hoffman William 
Published: February 2007

AbstractIntraperitoneal administration of a relatively small volume (0.2 ml) of plasma obtained from Sindbis virus‐infected animals containing approximately 480 units of interferon/ml effectively suppressed the development of adjuvant arthritis. Similarly, administration of interferon (624 units/rat/day, ip) prepared in vitro by exposing rat embryo fibroblast culture to poly I:C in the presence of cycloheximide also suppressed the development of adjuvant arthritis without affecting the humoral or the cell‐mediated immune response. The findings provide circumstantial evidence to the speculation that a virus or a virus‐like organism plays a role in the pathogenesis of this disease.
Synovectomy and total joint arthroplasty for recurrent hemarthroses in the arthropathic joint in hemophilia
Authors: London James T. , Kattlove Herman , Louie James S. , Forster Gary L. 
Published: February 2007

AbstractSevere hemophiliacs with intractable bleeding into one or more joints despite adequate clotting factor replacement therapy are difficult management problems. Synovectomy has controlled bleeding only in joints without significant arthritic destruction. Total joint replacements have been performed in arthropathic joints, but not when uncontrolled bleeding was a concurrent problem. This report describes a hemophiliac with uncontrolled bleeding into an arthritic knee who was successfully managed by combining synovectomy with total knee replacement.
Fat droplets and synovial fluid leukocytosis in traumatic arthritis
Authors: Graham Jimmy , Goldman John A. 
Published: February 2007

AbstractThe presence of fat droplets in synovial fluid signifies major or minor joint trauma with damage to the bones or adjacent supporting structures. Synovial fluids aspirated after traumatic hemorrhage usually have a low white blood cell count. In this report 2 patients with hemorrhagic effusions had synovial fluid leukocytosis, presumably secondary to lipid droplet phagocytosis. Lipid globules intra‐ and extracellulary in the synovial fluid and a top fatty layer in the hematrocit spin of the hemorrhagic synovial fluid are indications of the traumatic etiology of this inflammatory arthritis.
Susceptibility of rheumatoid and nonrheumatoid synovial cells to antibody‐dependent cell‐mediated cytotoxicity
Authors: Griffiths Marie M. , Smith Charles B. , Pepper Barbara J. 
Published: February 2007

AbstractFibroblastic cells derived from rheumatoid (RA) and nonrheumatoid (N‐RA) synovial tissue (synovial cells) were used as targets in assays of antibody‐dependent cell‐mediated cytotoxicity (ADCC). Synovial cells that had been pretreated with human alloantisera were rapidly lysed by normal human blood mononuclear cells. RA and N‐RA synovial cells were equally susceptible to ADCC under these assay conditions. Antibody to autologous synovial cells was not detected in sera from 10 patients with RA by this method of assay.
Serum antiimmunoglobulins reactive with human and rabbit igg in rheumatoid arthritis and other conditions
Authors: Stankaitiene Diana J. , Matulis Alfonsas A. , Guobys Henrikas , Jusenaite Janina P. 
Published: February 2007

AbstractIgG, IgA, and IgM antiimmunoglobulins reactive with human and rabbit IgG were measured in patients with rheumatoid arthritis (RA), patients with rheumatic fever or osteoarthritis, and normal individuals. Values of all antiimmunoglobulins were significantly evaluated in RA patients as compared with other groups and depended upon activity and stage of the disease. IgM antibodies with specificity for human IgG predominated quantitatively over others in sera of RA patients with high titers of RF, whereas most of those reactive with rabbit IgG in latex negative or positive RA patients belonged to IgG class. The reaction with human IgG included thermostable and thermolabile IgM antiimmunoglobulins but in that with rabbit IgG only thermostable antibodies were active.
Proliferative synovitis in hemophilia. biochemical and morphologic observations
Authors: Mainardi Carlo L. , Levine Peter H. , Werb Zena , Harris Edward D. 
Published: February 2007

AbstractThe synovium removed from the knee of a 10‐year‐old with hemophilia A was characterized morphologically and biochemically. The specimen showed villous hypertrophy with hyperplasia of synovial lining cells which contained abundant intracytoplasmic granules of hemosiderin.Monolayer cultures prepared from enzymatically dispersed tissue were characterized by pigment‐laden fibroblast‐like cells and round cells. Both explants of synovium and adherent cells secreted a large amount of latent collagenase and neutral proteinase into the culture medium. The secretion of these enzymes dropped sharply and intracellular pigment decreased with passage of these cultures. Lysozyme was secreted by the explants but was not detected in the monolayer culture medium. These data establish the degradative potential of the synovitis found in hemophilia and support the concept that recurrent hemarthrosis without inflammation is sufficient in and of itself to produce proliferative synovitis.
Shoulder swelling in rheumatoid arthritis secondary to subacromial bursitis
Authors: Huston Kent A. , Nelson Audrey M. , Hunder Gene G. 
Published: February 2007

AbstractA patient with rheumatoid arthritis was seen whose main complaint was marked swelling of the shoulders. Surgical exploration revealed the swelling to be secondary to subacromial bursitis; the glenohumeral joint appeared normal.
Normal distribution of acetylation phenotypes in systemic lupus erythematosus
Authors: Vansant Johnathan , Woosley Raymond L. , John J. Thomas , Sergent John S. 
Published: February 2007

AbstractPrevious reports have indicated that idiopathic systemic lupus erythematosus (SLE), like drug‐induced lupus, is more frequent in “slow” hepatic acetylators. Using dapsone acetylation rate to determine phenotypes, we found that of the 18 SLE patients studied, 9 were fast acetylators, 8 were slow, and 1 was indeterminate. This result (53% fast) is similar to acetylator phenotypes in our normal controls (50% fast) and in the population at large (52%).
Automated rheumatoid factor assay in a population of patients with rheumatic disease
Authors: Gall Eric P. , Templin David W. , Dito William R. 
Published: February 2007

AbstractRheumatoid factor has been measured in 128 patients having rheumatic disease to compare the Singer‐Plotz assay with an automated particle size assay. Correlation coefficient between the two methods using regression analysis revealed r = 0.89, P < 0.00001 when two different commercial sources of sensitized latex particles were used. Thus rheumatoid factor may be quantitated electronically and represented in arbitrary units (MPRF) without altering clinical interpretation. This methodology may be applicable to many other immunologic assays.
Hyporesponsiveness of lymphocytes to virus antigens in rheumatoid arthritis
Authors: Wolf Robert E. 
Published: February 2007

AbstractThe immune response of peripheral blood lymphocytes to measles, rubella, parainfluenza types 1, 2, and 3 RNA virus antigens, and to varicella‐zoster and herpes virus type 1 DNA virus antigens was evaluated in 14 patients with rheumatoid arthritis (RA) and 14 matched controls by assessing 3H‐thymidine incorporation. The results demonstrated hyporesponsivenss of lymphocytes from RA patients to virus antigens and phytohemag‐glutinin (PHA), which did not appear to be nonspecific because of a lack of correlation between response to virus antigens and response to mitogens. The pattern of decreased responsiveness was suggestive of a relative restriction of hyporesponsiveness to RNA virus antigens.
Decreased Lymphocyte Response To Pha, Con‐A, And Calcium Ionophore (A23187) In Patients With Ra And Sle, And Reversal With Levamisole In Rheumatoid Arthritis
Authors: Scheinberg Morton A. , Santos Leonilda , Mendes Nelson F. , Musatti Chloé 
Published: February 2007

AbstractThe mechanism of poor lymphocyte transformation to mitogens was studied in selected patients with rheumatoid arthritis and systemic lupus erythematosus. Low lymphocyte response to PHA and Con‐A in media containing autologous and homologous sera was usually associated with poor response to the calcium ionophore A23187, which induces blastogenesis by a different mechanism. The low lymphocyte response to mitogens in patients with rheumatoid arthritis could be restored by in vivo treatment with the anthelmintic drug, levamisole. The present findings suggest that intrinsic defects are responsible for the decreased cellular response in patients with rheumatoid arthritis and systemic lupus erythematosus.
Relationship of Hla‐Dw3 and Hla‐B8 to Sjögren'S Syndrome
Authors: Fye Kenneth H. , Terasaki Paul I. , Michalski Joseph P. , Daniels Troy E. , Opelz Gerhard , Talal Norman 
Published: February 2007

AbstractNineteen patients with Sjögren's syndrome were evaluated for the presence of HLA‐B8 and HLA‐Dw3. HLA‐B8 was found in 57.8% of patients and 20.1% of 96 controls (P > 0.0001). HLA‐Dw3 was detected in 73.7% of the patients and 24.0% of controls (P > 0.00001). Statistical evaluation of the association of both antigens with Sjögren's syndrome revealed that the primary association was with HLA‐Dw3 (P > 0.005). Patients with HLA‐Dw3 had a lower mean parotid salivary flow rate (0.8 ± 0.3 ml/10 minutes/gland versus 5.6 ± 1.2 ml/10 minutes/gland, P < 0.00004) and a more intense lymphocytic infiltration into labial salivary glands (focus score 7.2 ± 0.9 versus 3.4 ± 0.9, P < 0.04) than did patients without HLA‐Dw3. The difference in the intensity of the lymphocytic infiltration was even more significant when patients with both HLA‐Dw3 and HLA‐B8 were compared with patients with neither antigen (focus score 7.5 ± 1.0 versus 2.8 ± 0.8, P < 0.02). In addition, all patients with severe keratoconjunctivitis sicca had both antigens. Our observations suggest that a number of genes may interact to determine susceptibility and severity in Sjögren's syndrome.
Rapid Assessment of 99MTc‐Pertechnetate Uptake in the Knee Joint as a Parameter of Inflammatory Activity
Authors: Boerbooms Agnes M. Th. , Buys Wil C. A. M. 
Published: February 2007

AbstractShortly after intravenous injection of 99mTechnetium‐pertechnetate (99mTcO4−)(200m̈Ci), the activity of the knee joints was studied in patients with clinical arthritis of one or both knees and compared with that in normal subjects. A rest period directly before the study improved reproducibility. The values found shortly after injection were comparable with measurements at the maximum. The significance of the 99mTcO4− uptake in comparison with the histologic findings in cases of doubtful arthritis was examined.
Idiopathic Multicentric Osteolysis
Authors: Whyte Michael P. , Murphy William A. , Kleerekoper Michael , Teitelbaum Steven L. , Avioli Louis V. 
Published: February 2007

AbstractGenetic, rheumatologic, immunologic, metabolic, and renal studies of a father and son with idiopathic multicentric osteolysis are reported. The disorder appeared through mutation. The father developed symptoms as an infant, his son at age 4 years and 9 months. Both have micrognathia and hypotelorism and were exceptionally tall during the symptomatic phase of their disease. Biopsies of the son's wrist showed normal synovium, encroachment on cartilage by fibrocellular tissue, and both osteoclastic resorption and repair of affected bone. Hydroxyproline in his urine was increased. No immunologic, renal, or other metabolic abnormalities were identified.
Collagen in the cellular and fibrotic stages of scleroderma
Authors: Fleischmajer Raul , Gay Steffan , Meigel Wilhelm N. , Perlish Jerome S. 
Published: February 2007

AbstractThe collagen in localized and systemic scleroderma skin was studied by light microscopy with silver impregnation (50 patients), electron microscopy (14 patients), and immunofluorescence microscopy using specific antibodies against Type I and Type III collagens (12 patients). In the cellular stage, the dermis and adipose tissue revealed perivascular or diffuse cellular infiltrates (mostly lymphocytes, plasma cells, and macrophages), accompanied by deposition of Type III collagen. The lower dermis also showed an increase in Type III collagen. In the fibrotic stage, the papillary layer showed a reduction and/or clumping of Type III collagen as compared to normal skin. The lower dermis and the adipose tissue revealed compact collagen consisting exclusively of Type I collagen or a mixture of Type I and Type III collagen. The pattern of Type III collagen distribution was similar to that of reticulin, thus suggesting that at least some reticulin fibrils may represent Type III collagen.
Enhancement of urate solubility by connective tissue
Authors: Perricone Elaine , Brandt Kenneth D. 
Published: February 2007

AbstractProteoglycan aggregates (PGC) facilitated dissolution of 2½ times more sodium urate crystals than nonaggregated proteoglycans. This effect of aggregates on urate solubility was abolished by digestion of the aggregates with hyaluronic acid β1 ← 3 hydrolase. PGC, however, did not sustain urate concentrations in supersaturated solutions. Potassium urate was severalfold more soluble than sodium urate. In vivo, where they exist predominantly as their sodium salts in the extracellular connective tissue, proteoglycans may not markedly influence the solubility of sodium urate.
Chrysotherapy in psoriatic arthritis
Authors: Dorwart Bonnie B. , P. Gall Eric , Schumacher H. Ralph , Krauser Ronald E. 
Published: February 2007

AbstractChrysotherapy was given to 14 patients with refractory psoriatic polyarthritis and to a comparable group of 42 patients with rheumatoid arthritis. The psoriatic patients had a higher rate of remission on gold and less severe toxicity than the rheumatoid arthritis patients. Psoriatic skin lesions were not affected by chrysotherapy.
Electron microscopic morphology of immunoglobulin aggregates and their interactions in rheumatoid articular collagenous tissues
Authors: Ohno Osamu , Cooke T. Derek 
Published: February 2007

AbstractImmunoelectron microscopy for IgG and IgA was combined with plain electron microscopy and light microscopy to study a variety of articular collagenous tissues from 14 cases of classic rheumatoid arthritis. Numerous extensive aggregates of IgG and IgA positive material were found widely spread in locations that coincided with immunofluorescent staining for these immunoglobulins and B1c. This Ig positive material is thought to represent deposits of immune complexes. As great and greater amounts were seen in fibrocartilage menisci as in hyaline cartilage. A single specimen of disease tendon was also positive. Severe pathologic changes of the matrix characterized by loss of normal morphology, alterations in collagen, and overall reduced density were observed in regions of aggregate deposition with a consistent replacement and disappearance of collagen in the locale of the aggregates themselves. Polymorphonuclear cells in regions of degraded hyaline and tendon matrix were seen to have phagocytosed aggregates. These data give some credence to a direct role of immune aggregates in rheumatoid arthritis articular collagenous tissues in disease pathogenesis.
A controlled study of ana+ rf‐ arthritis
Authors: Linn Julius E. , Hardin Joe G. , Halla James T. 
Published: February 2007

AbstractThirty (7.5%) of 401 adult rheumatoid arthritis (RA) patients were antinuclear antibody positive (ANA+) and rheumatoid factor negative (RF‐), and 15 of 16 patients who were followed for a year or longer remained so. Clinical, other laboratory, and radiographic parameters were compared among this group and 90 matched RA controls divided into ANA+RF+, ANA‐RF+, and ANA‐RF‐ groups. All groups were identical, except the ANA‐RF‐ group, which had significantly fewer nodules and less destructive disease than the other three.
The satellite arthritis clinic
Authors: Pinals Robert S. 
Published: February 2007

AbstractFor nine years an Arthritis Consultation Clinic has served a large community that did not have a rheumatologist. A university‐based rheumatology section from another city, a local hospital, the United Way, a chapter of the Arthritis Foundation, and the County Medical Society have all contributed to the operation of the clinic. Such a clinic may be viewed as a stage in the regional development of rheumatologic care. Although primarily intended as a community service program, the clinic may also be useful in professional education on several levels.
Boundary lubricating ability of synovial fluid in degenerative joint disease
Authors: Davis Warren H. , Lee S. L. , Sokoloff Leon 
Published: February 2007

AbstractThe boundary lubricating ability of eleven synovial fluids was measured in a miniaturized latex–glass test system. The specimens were obtained at necropsy from knees in which the degree of degenerative joint disease varied from none to very severe. The lubricating ability of the fluid was independent of the viscosity over a wide range of shear rates. It was not diminished even in advanced lesions. In two additional fluids, the mucin clot was poor; the lubricating ability of one of these was compromised. Thus, although degenerative joint disease, during its quiescent stages, is not associated with defective synovial lubrication, the possibility that transient defects might lead to cartilage wear during life has not been excluded. The measurements are believed to be valid indicators of boundary lubricating ability under physiological conditions despite the fact that the test surfaces were not cartilaginous and the loading was relatively low (up to 47 pounds per square inch).
Identification and characterization of two new soluble nuclear antigens reactive with sera of patients with connective tissue diseases
Authors: Miyawaki Shoji , Kohmoto Kiichi , Kurata Noriyuki , Ofuji Tadashi 
Published: February 2007

AbstractTwo antigens, temporarily referred to as MU and TM antigens after the original serum, that are closely related to the nucleolus have been identified in the nuclear soluble extract. Both antigens reacted with the sera of a small number of patients with various connective tissue diseases, and both were different from antigens described previously in these disorders. MU antigen was sensitive to the digestion with RNase and trypsin, and was shown to be equivalent to the nuclear ribosomal components in the nuclear extract. TM antigen was resistant to the digestion with RNase and trypsin, and was localized in the nucleolus and extranucleolar portion of nuclei, but the precise nature of TM has not been established.
The costs of rheumatoid arthritis. a patient‐oriented study of chronic disease costs
Authors: Meenan Robert F. , Yelin Edward H. , Henke Curtis J. , Curtis David L. , Epstein Wallace V. 
Published: February 2007

AbstractTo detail the cost for one year of a chronic disease, 50 patients with Stage III rheumatoid arthritis were surveyed. Direct medical costs for this group were three times the national average, and 58% of these costs were covered by insurance. Indirect costs due to lost income were at least three times the direct medical costs, and transfer payments covered only 42% of these costs. Fifty‐eight percent of the study group also sustained a major psychosocial loss. Uncovered income losses were the greatest economic burden for individuals with chronic rheumatoid arthritis. This striking ratio of indirect to direct medical costs has important implications for medical practice and health policy.