bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthocyanin-Mediated Autophagy in Hepatocellular Carcinoma: Gene Associations and Prognostic Implications
Authors: Du Juan , Shen Enhua 
Published: April 2024

Background:
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy
accompanied by high incidence, poor outcomes, and high mortality. Anthocyanins can inhibit
tumor proliferation, migration, invasion, and promote apoptosis. Moreover, autophagy-related
genes (ARGs) may play vital roles in HCC progression. This study aimed to decipher the mechanisms
through which anthocyanins influence HCC via ARGs and to establish a novel prognostic
model.

Methods:
Based on data from public databases, differential analysis and the Venn algorithm
were employed to detect intersecting genes among differentially expressed genes (DEGs), anthocyanin-
related targets, and ARGs. Consensus clustering was implemented to delineate molecular
subtypes of HCC. The prognostic model was developed by Cox regression analyses.
CIBIRSORT was engaged to assess the immune cell infiltration. Kaplan-Meier (KM) analysis
and receiver operating characteristic (ROC) curve were utilized to evaluate the predictive efficiency
of the prognostic signature.

Results:
A total of 36 intersecting genes were identified from overlapping 1524 ARGs, 537 anthocyanin-
related targets, and 5247 DEGs. Consensus clustering determined three molecular
subtypes (cluster 1, cluster 2, and cluster 3). Cluster 1 showed worse outcomes and remarkably
higher abundances of plasma cells and T follicular helper cells. Furthermore, four prognostic
signatures [KDR (Kinase insert domain receptor), BAK1 (BCL2 antagonist/killer 1), HDAC1
(Histone deacetylase 1), and CDK2 (Cyclin-dependent kinase 2)] were identified and showing
substantial predictive efficacy.

Conclusion:
This investigation identified three molecular subtypes of HCC patients and proposed
a promising prognostic signature comprising KDR, BAK1, HDAC1, and CDK2, which
could supply further robust evidence for additional clinical and functional studies.
Laser Synthesis of Catalytically Active Materials for Organic Synthesis
and Sensor Technology
Authors: Kochemirovskaia Svetlana , Novomlinsky Maxim , Alyukov Ilya , Denisova Yulia , Ischuk Diana , Mokhorov Dmitriy , Kochemirovsky Vladimir 
Published: April 2024

Introduction:
The catalytic activity of metallic nanomaterials depends on their surface morphology. A widely known method is the laser synthesis of metal nanostructures by depositing on dielectric surfaces from aqueous solutions containing metal complexes. The article analyzes the factors that favor the production of conductive, catalytic, and sensory-active deposits by laser method. It is shown that the two main factors is the presence of a large number of charged defects on heterophase surfaces and the structure of metal-containing complexes in solution. This is typical for mono- and bimetallic alloys, the components of which interact with the laser beams according to the autocatalytic type. Using the example of laser deposition from solutions of Co, Ni, Fe, Zn, and Ag salts with homo- and heterophase dielectrics, the sensory and catalytic properties of the deposits are compared by impedance spectroscopy and voltammetry. It has been shown that heterophase precipitation significantly enhances the catalysis response.

Background:
It is known that the highest catalytic activity exhibits nanostructured and highly porous materials with a large specific surface area and materials containing surface heterogeneity in the form of charged acid-base centers. Such materials are necessary for the creation of new catalysts for organic synthesis and for the creation of new sensor materials for enzyme-free microbiosensors. Active development of new methods for the synthesis of such materials is underway. But not all of them give the expected result.

Methods:
Laser synthesis methods have the best prospects, including the method of laser-induced metal deposition. This is the laser synthesis of metal nanostructures by depositing dielectric surfaces from aqueous solutions containing metal complexes.

Results:
Аrticle analyzes the factors that favor the production of conductive, catalytic, and sensory-active deposits by laser method. It is shown that the two main factors are the presence of a large number of charged defects on heterophase surfaces and the structure of a metal-contained complex in solution. This is typical for mono- and bimetallic alloys, the components of which interact with the laser beam according to the autocatalytic type. Using the example of laser deposition from solutions of Co, Ni, Fe, Zn, and Ag salts with homo- and heterophase dielectrics, the sensory and catalytic properties of the deposits are compared by impedance spectroscopy and voltammetry.

Conclusion:
It has been shown that heterophase precipitation significantly enhances the catalysis response. It is shown that the laser deposition reaction has an autocatalytic mechanism in a dynamic mode. The results of autocatalysis can be used in a stationary mode to create a microbiosensor for glucose, as well as to create a technology for laser refining rare metals and hydrogen energy in a dynamic mode.
Development of Electrochemical Microtextured Cell for Fabrication of Complex Micropattern
Authors: Kunar Sandip , Swapna Sri M. Naga , Anusha P. , Satishkumar P , Veeranjaneyulu Itha , Rao N. Srinivasa , Vijayakumar S. 
Published: April 2024

Introduction:
This paper highlights the representative patents related to the application
of maskless electrochemical micromachining (EMM) using microtextured tools and developed
cells under electrolysis conditions for the generation of high-quality complex patterns, i.e., cascade
micropattern on stainless steel.

background:
Electrochemical Microtextured Cell

Method:
To acquire high accuracy level, the workpiece and tools are fixtured properly in the developed
microtextured cell, and a developed vertical cross-flow system is utilized for the generation
of a precise cascade micropattern. An electrochemical microtextured cell is designed and developed
inexpensively for the fabrication of high-quality complex micropatterns. The eco-friendly
combined electrolyte of NaNO3 and NaCl is employed for precise micro texturing.

Result:
The consequence of predominant input factors, i.e., IEG, voltage, and flow rate, are explored
on machining rate, precision, depth, and surface finish during complex micro-texturing using
developed microtextured cells. The complex microtextured tool is fixtured in tool holding device
in a developed microtextured cell and fabricates nineteen precise complex micropatterns.

Conclusion:
An effort has been made to find suitable input factors for the generation of precise
complex micropatterns.
Cement Dosage and Compressive Strength Correlation in Rammed Earth Walls: a Case Study
Authors: Ariza Flores Victor Andre , Ortega Hilario Elizabeth Fiorella 
Published: April 2024

In this study, we investigated the correlation and development of a linear regression model between the variables "added cement" and "compressive strength of rammed earth walls" constructed with aggregates obtained from Colpa Alta, Huánuco, Peru through bivariate analysis and multivariate data analysis. This analysis was motivated by the increasing difficulty for the local population to build confined masonry housing due to the increase in the prices of building materials brought on by the COVID-19 pandemic. In this context, rammed earth walls offer a more affordable alternative to the traditional system, although it is necessary to improve their structural capacity. 60 samples of aggregates were collected in situ, following the Peruvian Technical Standard E-080. Subsequently, they were divided into four groups of 15 samples each, where 5%, 10% and 15% of the aggregate were replaced by cement. Compressive strength tests were performed, and the results were analysed using statistical techniques. The findings revealed a significant increase in compressive strength in samples containing cement compared to conventional rammed earth blocks. It was obtained that there is a strong correlation between the variable "added cement" and "compressive strength of rammed earth walls". The linear regression model quantitatively explained the influence of cement on compressive strength.
Application of AI in Sepsis: Citation Network Analysis and Evidence Synthesis
Authors: Wu MeiJung , Islam Md Mohaimenul , Poly Tahmina Nasrin , Lin Ming-Chin 
Published: April 2024

Background
Artificial intelligence (AI) has garnered considerable attention in the context of sepsis research, particularly in personalized diagnosis and treatment. Conducting a bibliometric analysis of existing publications can offer a broad overview of the field and identify current research trends and future research directions.

Objective
The objective of this study is to leverage bibliometric data to provide a comprehensive overview of the application of AI in sepsis.

Methods
We conducted a search in the Web of Science Core Collection database to identify relevant articles published in English until August 31, 2023. A predefined search strategy was used, evaluating titles, abstracts, and full texts as needed. We used the Bibliometrix and VOSviewer tools to visualize networks showcasing the co-occurrence of authors, research institutions, countries, citations, and keywords.

Results
A total of 259 relevant articles published between 2014 and 2023 (until August) were identified. Over the past decade, the annual publication count has consistently risen. Leading journals in this domain include Critical Care Medicine (17/259, 6.6%), Frontiers in Medicine (17/259, 6.6%), and Scientific Reports (11/259, 4.2%). The United States (103/259, 39.8%), China (83/259, 32%), United Kingdom (14/259, 5.4%), and Taiwan (12/259, 4.6%) emerged as the most prolific countries in terms of publications. Notable institutions in this field include the University of California System, Emory University, and Harvard University. The key researchers working in this area include Ritankar Das, Chris Barton, and Rishikesan Kamaleswaran. Although the initial period witnessed a relatively low number of articles focused on AI applications for sepsis, there has been a significant surge in research within this area in recent years (2014-2023).

Conclusions
This comprehensive analysis provides valuable insights into AI-related research conducted in the field of sepsis, aiding health care policy makers and researchers in understanding the potential of AI and formulating effective research plans. Such analysis serves as a valuable resource for determining the advantages, sustainability, scope, and potential impact of AI models in sepsis.
Global Rate of Willingness to Volunteer Among Medical and Health Students During Pandemic: Systemic Review and Meta-Analysis
Authors: Mahsusi Mahsusi , Hudaa Syihaabul , Nuryani Nuryani , Fahmi Mustofa , Tsurayya Ghina , Iqhrammullah Muhammad 
Published: April 2024

Background
During health crises such as the COVID-19 pandemic, shortages of health care workers often occur. Recruiting students as volunteers could be an option, but it is uncertain whether the idea is well-accepted.

Objective
This study aims to estimate the global rate of willingness to volunteer among medical and health students in response to the COVID-19 pandemic.

Methods
A systematic search was conducted on PubMed, Embase, Scopus, and Google Scholar for studies reporting the number of health students willing to volunteer during COVID-19 from 2019 to November 17, 2023. The meta-analysis was performed using a restricted maximum-likelihood model with logit transformation.

Results
A total of 21 studies involving 26,056 health students were included in the meta-analysis. The pooled estimate of the willingness-to-volunteer rate among health students across multiple countries was 66.13%, with an I2 of 98.99% and P value of heterogeneity (P-Het)<.001. Removing a study with the highest influence led to the rate being 64.34%. Our stratified analyses indicated that those with older age, being first-year students, and being female were more willing to volunteer (P<.001). From highest to lowest, the rates were 77.38%, 77.03%, 65.48%, 64.11%, 62.71%, and 55.23% in Africa, Western Europe, East and Southeast Asia, Middle East, and Eastern Europe, respectively. Because of the high heterogeneity, the evidence from this study has moderate strength.

Conclusions
The majority of students are willing to volunteer during COVID-19, suggesting that volunteer recruitment is well-accepted.
Research on the Reform and Innovation of International Student Training Mode-Bases on Textile Engineering Major
Authors: Mai Wei , Dong Yue , Wang Chunhong 
Published: April 2024

With the rapid development of world economy, international student cultivation will be facing new challenges. The article focuses on analyzing the overall development of international education in China and the practical problems and major challenges faced by universities in the process of cultivating and educating international students. And taking the textile engineering major as an example, combined with the current international situation and background, it tries to propose innovative measures and ideas in terms of platform construction, enrollment channels, and professional course construction, practical teaching and other aspects for the reform of international education, in order to provide reference for the training of international students in the future.
Aperfeiçoamento sustentável no processo de ensino-aprendizagem do exame químico provisório de cocaína
Authors: Da Silva Stelato Ederson , Santos Avelar Kátia Eliane , Indio do Brasil da Costa Vanessa 
Published: April 2024

O presente artigo, que se trata de uma revisão narrativa da literatura, focou no aperfeiçoamento do processo de ensino-aprendizagem do exame químico provisório de cocaína, orientando a abordagem de docentes e qualificando os discentes de todos os níveis, principalmente, em cursos de formação técnica profissional das academias de polícia, estabelecendo a triagem de métodos sustentáveis tanto no âmbito da justiça quanto na esfera ambiental do citado exame, tendo os seguintes critérios estabelecidos: sensibilidade, seletividade, tempo de execução, registro fotográfico e redução do impacto ambiental. Com base na análise teórica, os métodos mais sustentáveis foram: o teste de Scott e cromatografia em camada delgada (CCD) —principalmente pela questão da seletividade— tendo o CCD como um teste de resultado mais genuíno, embora varie conforme sistema solvente utilizado; e o imunocromatográfico que se destaca especialmente por contribuir com a redução do impacto ambiental, porém, como só foi constatado apenas um artigo testando a eficácia desse método para esse fim, fica ainda a dúvida de sua eficiência na questão da seletividade.
Superporous Hydrogel: A Novel Approach for Safe Gastroretentive Drug Delivery System
Authors: Pawar Darshana , Jamindar Darshan , Farooqui Nadeem A. , Manocha Nimita 
Published: April 2024

Superporous hydrogel are developed initially as novel drug delivery system to retain dosage form in upper gastrointestinal tract, and absorbs drug in gastric medium. The generation-based classification of superporous hydrogel is covered in this review. The hydrophilic polymer networks formed by the molecular entanglements which absorb water up to thousands of times to their dry weight. These systems swells quickly and resist in an extremely acidic condition in stomach. This hydrogel is instantly swell through capillary force which is driven by absorption of water through an open porous structure. This system provides better solubility and bioavailability by targeting the specific site of absorption. The conventional superporous hydrogels have the poor mechanical strength which is overcome by developing the second superporous hydrogel generation composites and the third-generation superporous hydrogel hybrids. This article has mainly focused on the classification, techniques, drug loading, research papers, characterizations and applications of superporous hydrogel.
Keywords: Gastric retention, Cross-linking, Superporous hydrogel, Swelling rate, Elastic property, Hydrophilic polymer networks.
Fulvic acid transdermal patch: Its properties, optimization and release
Authors: Konnova Maria Alex , Volkov Alexander A. , Melnikova Nina B. 
Published: April 2024

There is a high demand for the design of fulvic acids (FA) transdermal patches being natural biologically active substances with a wide action. The difficulties in FA transdermal patches creating are due to the peculiarities of FA obtaining with high purity and solubility, the existence of many several polymorphic forms, as well as the problems of their insertion into dosage forms. In this work, we modified the FA isolation as water-soluble polymorph. This operation allowed us to reduce the impurities in the product, to optimize the formulation of the emulsion-based transdermal patches, to provide a quantitative assessment of FA release. Data of IR, 13C NMR, AAS, ICP-AES-spectra, direct and reverse titration of carboxyl groups and phenolic hydroxyls, potentiometry, molecular weight determination by cryoscopy (M.m=740 g/mol), fluorescent analysis, solubility (3.3 mL of water per gram) confirmed the receipt of the desired polymorph. Optimization of the transdermal patches formulations by Response Surface Methodology and release evaluation and kinetics mathematical modeling using a Franz cell showed the preferences of Pluronic Kolliphor p237 as a transcutant. The obtained water-soluble FA can be used as a potential component of transdermal patches with controlled release parameters.
Keywords: fulvic acid, transdermal patches, pluronics, release
Concept of Cosmetology and its Historical Background in Unani Perspective
Authors: Manzoor Faisel 
Published: April 2024

Unani physicians have paid great attention to the use of cosmetics since very ancient times. Around 4000 BC first archaeological evidence of cosmetics usage was found in ancient Egypt. The use of perfumes, oils, burning of aromatic incense, copper eye shadows, lamp black for eyes and dying of hairs red were in practice by ancient Egyptians. Unani literature is very rich in cosmeceutical formulations taking care of appearance and dealing with cosmetic diseases in humans. In Unani classical text like Kitab-ul-Mansoori, Al-Hawi-fil-Tib, Kamil-us-Sana, Al-Qanoon-fit-Tib, Zakheera-e-Khwarzam Shahi, the details of cosmetics are mentioned under the headings of Tazeeniyaat. This systematic review can be concluded that various cosmetics and cosmeceuticals prevailing in contemporary era may have been introduced or inspired by these physicians. There are several single drugs or compound formulations described in Unani classical text. Unani cosmetics can be a very good choice owing to their range, low cost and safety and can also be incorporated as an adjuvant in several contemporary preparation. There are several Unani cosmeceuticals are described in unani classical text like Solid Cosmeceutical (Ghaza, Ghaliya, Kajal), Semi-solid Cosmeceutical (Tila, Zimad, Ubtan) and Liquid cosmeceutical (Ghusool, Pashoya).
Keywords: Unani Medicine, Cosmetics, Cosmeceuticals, Tazeeniyaat
Strategies for Managing Anemia in Chronic Kidney Disease
Authors: Biju Blessy , D'Cruz Adlin , Jiby Sneha , Devassy Melvin , Jacob Rosmin 
Published: April 2024

Anemia is a common complication in chronic kidney disease (CKD) and is associated with decreased quality of life, deteriorating kidney function, increased illness, higher mortality rates, and elevated healthcare costs. Management of CKD-related anemia aims to enhance renal function (when feasible) and bolster red blood cell production. Anemia in chronic kidney disease (CKD) stems from a variety of factors, including reduced erythropoietin (EPO) production, inadequate iron availability or functionality, and inflammation leading to heightened levels of hepcidin, among other causes. Typical treatment for CKD-related anemia involves administering oral or intravenous iron supplements in conjunction with erythropoiesis-stimulating agents (ESAs). Over the past decade, erythropoiesis-stimulating agents (ESAs) have proven effective in boosting hemoglobin (Hb) levels for many patients. However, concerns about their safety, particularly regarding increased cardiovascular risk—especially at high doses and in hyporesponsive patients—have emerged. As a result, there's been a shift towards adopting more cautious Hb targets. Iron deficiency is widespread among CKD patients, particularly in those not undergoing dialysis. While iron supplementation has traditionally been used to support anemia management, there's growing recognition of the potential benefits of intravenous iron therapy, especially in the context of heart failure. HIF prolyl hydroxylase inhibitors are promising new drugs being clinically evaluated as alternatives to ESAs for anemia treatment in CKD patients. Initial data suggest they effectively boost endogenous erythropoietin production with potential benefits like lower peak concentrations, efficacy in inflamed patients, and improved iron utilization. However, further research is needed to confirm their safety and efficacy in the long term use.
Keywords: anemia, chronic kidney disease, erythropoiesis-stimulating agents, iron, HIF-prolyl-hydroxylase inhibitors
Assessment of Parents Knowledge, Attitude and Practice about Child Vaccination in Selected Rural Areas of Kalaburagi District, India
Authors: Sandeep S , Biradar S S , Veeresh Veeresh 
Published: April 2024

Objective: Immunization has evolved as one of the most successful public health interventions, reducing the incidence of infectious diseases and improving quality of life. This study was conducted to analyze the level of knowledge, attitude and experience of childhood vaccination among local participants from selected rural areas of Kalaburagi District, which can be related to the immunization status of their children.
Method: The Prospective, Cross-Sectional study was conducted at selected villages of rural areas in Kalaburagi district. Parents were enrolled into the study by considering the study criteria. Demographic details and other relevant data were collected at pre-test and post-test
Results: A total of 631 parents from 10 selected rural areas were enrolled in the study out of which 611 parents completed the study and 20 parents did not complete the study. It was evident that 470(76.92%) children’s immunization was completed according to schedule, 73(11.95%) children’s immunization was not complete according to schedule and 68(11.13%) parents did not know whether child immunization was complete according to schedule or not. The pre and post-test KAP score was assessed using SPSS software and Chi- Square test was carried out to analyze the Statistical significance. The study was statistically significant at p-value of <0.01.
Conclusion: The study concluded that better awareness of childhood immunization among parents led to increased immunization experience in their children. Health workers must be trained at the grass root level and through them the importance of childhood vaccination must spread to all rural areas.
Keywords: Immunization, Knowledge, Attitude, Practice