bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Polymorphism in the APE1 Gene Promoter is Associated with Lung Cancer Risk
Authors: Lo Yen-Li , Jou Yuh-Shan , Hsiao Chin-Fu , Chang Gee-Chen , Tsai Ying-Huang , Su Wu-Chou , Chen Kuan-Yu , Chen Yuh-Min , Huang Ming-Shyan , Hu Chi Yuan , Chen Chien-Jen , Hsiung Chao A. 
Published: January 2009

Abstract
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway, which is the primary mechanism for the repair of DNA damage caused by oxidation and alkylation. We hypothesized that polymorphisms of APE1 are associated with risk for lung cancer. In the hospital-based matched case-control study, a total of 730 lung cancer cases and 730 cancer-free controls were genotyped for four APE1 haplotype-tagging polymorphisms (that is, -656T&gt;G, 400A&gt;G, 630T&gt;C, and 1350T&gt;G). Among them, the single-nucleotide polymorphism -656T&gt;G located in the promoter region of APE1 was significantly associated with risk for lung cancer. We found that, compared with -656 TT homozygotes, the variant genotypes were associated with a significantly decreased risk [adjusted odds ratio, 0.51; 95% confidence interval (95% CI), 0.33-0.79 for -656 TG; adjusted odds ratio, 0.43; 95% CI, 0.25-0.76 for -656 GG, respectively]. Furthermore, we found a statistically significant reduced risk of -656T&gt;G variants among heavy smokers (adjusted odds ratio, 0.52; 95% CI, 0.30-0.93 for -656 TG; adjusted odds ratio, 0.27; 95% CI, 0.13-0.57 for -656 GG, respectively), with a significant gene-smoking interaction (P = 0.013). A similar gene-smoking interaction in the context of APE1 haplotypes was also observed. The in vitro promoter assay revealed that the -656 G allele had a significantly higher transcriptional activity than that of the -656 T allele. Together, our results suggest that polymorphisms of the APE1 gene possibly interact with smoking and may contribute to the development of lung cancer. (Cancer Epidemiol Biomarkers Prev 2009;18(1):223–9)
Physical Activity and Postmenopausal Breast Cancer Risk in the NIH-AARP Diet and Health Study
Authors: Peters Tricia M. , Schatzkin Arthur , Gierach Gretchen L. , Moore Steven C. , Lacey James V. , Wareham Nicholas J. , Ekelund Ulf , Hollenbeck Albert R. , Leitzmann Michael F. 
Published: January 2009

Abstract
Background: Although physical activity has been associated with reduced breast cancer risk, whether this association varies across breast cancer subtypes or is modified by reproductive and lifestyle factors is unclear.
Methods: We examined physical activity in relation to postmenopausal breast cancer risk in 182,862 U.S. women in the NIH-AARP Diet and Health Study. Physical activity was assessed by self-report at baseline (1995-1996), and 6,609 incident breast cancers were identified through December 31, 2003. Cox regression was used to estimate the relative risk (RR) and 95% confidence interval (95% CI) of postmenopausal breast cancer overall and by tumor characteristics. Effect modification by select reproductive and lifestyle factors was also explored.
Results: In multivariate models, the most active women experienced a 13% lower breast cancer risk versus inactive women (RR, 0.87; 95% CI, 0.81-0.95). This inverse relation was not modified by tumor stage or histology but was suggestively stronger for estrogen receptor (ER)-negative (RR, 0.75; 95% CI, 0.54-1.04) than ER-positive (RR, 0.97; 95% CI, 0.84-1.12) breast tumors and was suggestively stronger for overweight/obese (RR, 0.86; 95% CI, 0.77-0.96) than lean (RR, 0.95; 95% CI, 0.87-1.05) women. The inverse relation with physical activity was also more pronounced among women who had never used menopausal hormone therapy and those with a positive family history of breast cancer than their respective counterparts.
Conclusions: Physical activity was associated with reduced postmenopausal breast cancer risk, particular to ER-negative tumors. These results, along with heterogeneity in the physical activity-breast cancer relation for subgroups of menopausal hormone therapy use and adiposity, indicate that physical activity likely influences breast cancer risk via both estrogenic and estrogen-independent mechanisms. (Cancer Epidemiol Biomarkers Prev 2009;18(1):289–96)
Incidence of Ovarian, Peritoneal, and Fallopian Tube Carcinomas in the United States, 1995-2004
Authors: Goodman Marc T. , Shvetsov Yurii B. 
Published: January 2009

Abstract
Objective: The objective of this analysis was to describe the distribution of pelvic carcinomas in the United States by demographic, pathologic, and clinical features.
Methods: Carcinomas of the ovary (n = 112,541), peritoneum (n = 6,458), and fallopian tube (n = 3,479) were identified through 24 population-based registries in the United States during the period 1995 to 2004. Age-adjusted incidence rates were calculated per million population using counts derived from the 2000 U.S. census.
Results: The age-adjusted incidence rate for ovarian carcinoma (119.9 per million) was substantially higher than for peritoneal (6.78 per million) or fallopian tube (3.72 per million) carcinomas. White women had the highest rates for all three malignancies. Rates for peritoneal carcinoma were lowest among Black women (2.88 per million) and rates for fallopian tube carcinoma were lowest among Hispanic women (2.45 per million). Serous carcinomas were the most commonly diagnosed histologic type for all anatomic sites. Peritoneal carcinomas were diagnosed at later ages (mean, 67 years) and more advanced stages (85% regional/distant) compared with fallopian tube carcinomas (mean, 64 years; 62% regional/distant) and ovarian carcinomas (mean, 63 years; 76% regional/distant). Incidence for all three pelvic carcinomas was lowest in the South. Time trend analyses between 1973 and 2005 exhibited a significant decline in ovarian carcinoma incidence and rises in the rates of peritoneal and fallopian tube cancers.
Conclusions: Similarities in the incidence patterns for ovarian, peritoneal, and fallopian tube carcinomas support the likelihood of a common molecular pathogenesis. (Cancer Epidemiol Biomarkers Prev 2009;18(1):132–9)
Menstrual and Reproductive Factors and Risk of Renal Cell Cancer in the Multiethnic Cohort
Authors: Setiawan Veronica Wendy , Kolonel Laurence N. , Henderson Brian E. 
Published: January 2009

Abstract
A relationship between female reproductive and menstrual factors, including exogenous hormone use, and renal cell cancer (RCC) has been hypothesized, but supporting epidemiologic evidence is limited and inconsistent. Here, the association of reproductive and menstrual factors with RCC risk was examined among 106,036 Hawaii-Los Angeles Multiethnic Cohort female participants who entered the cohort between 1993 and 1996. During an average 10.6 years of follow-up, 229 RCC cases were identified among these women. Data on known and potential risk factors were obtained from the baseline questionnaire. Relative risks and 95% confidence intervals for RCC associated with each factor were estimated using Cox proportional hazard models stratified by race/ethnicity, study center, and menopausal status and adjusted for age and several confounding factors. We found no evidence of association between RCC and parity, age at first birth, age at menarche, age and type of menopause (hysterectomy or bilateral oophorectomy), use and duration of oral contraceptive, and type and duration of postmenopausal hormone use. Our results do not support the hypothesis that hormone-related factors play an etiologic role in RCC among women. (Cancer Epidemiol Biomarkers Prev 2009;18(1):337–40)
A Pilot Study of Sampling Subcutaneous Adipose Tissue to Examine Biomarkers of Cancer Risk
Authors: Campbell Kristin L. , Makar Karen W. , Kratz Mario , Foster-Schubert Karen E. , McTiernan Anne , Ulrich Cornelia M. 
Published: January 2009

Abstract
Examination of adipose tissue biology may provide important insight into mechanistic links for the observed association between higher body fat and risk of several types of cancer, in particular colorectal and breast cancer. We tested two different methods of obtaining adipose tissue from healthy individuals. Ten overweight or obese (body mass index, 25-40 kg/m2), postmenopausal women were recruited. Two subcutaneous abdominal adipose tissue samples were obtained per individual (i.e., right and left lower abdominal regions) using two distinct methods (method A: 14-gauge needle with incision, versus method B: 16-gauge needle without incision). Gene expression was examined at the mRNA level for leptin, adiponectin, aromatase, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in flash-frozen tissue, and at the protein level for leptin, adiponectin, IL-6, and TNF-α following short-term culture. Participants preferred biopsy method A and few participants reported any of the usual minor side effects. Gene expression was detectable for leptin, adiponectin, and aromatase, but was below detectable limits for IL-6 and TNF-α. For detectable genes, relative gene expression in adipose tissue obtained by methods A and B was similar for adiponectin (r = 0.64, P = 0.06) and leptin (r = 0.80, P = 0.01), but not for aromatase (r = 0.37,P = 0.34). Protein levels in tissue culture supernatant exhibited good intra-assay agreement [coefficient of variation (CV), 1-10%], with less agreement for intraindividual agreement (CV, 17-29%) and reproducibility, following one freeze-thaw cycle (CV, &gt;14%). Subcutaneous adipose tissue biopsies from healthy, overweight individuals provide adequate amounts for RNA extraction, gene expression, and other assays of relevance to cancer prevention research.
Inflammation-Associated Serum and Colon Markers as Indicators of Dietary Attenuation of Colon Carcinogenesis in ob/ob Mice
Authors: Mentor-Marcel Roycelynn A. , Bobe Gerd , Barrett Kathleen G. , Young Matthew R. , Albert Paul S. , Bennink Maurice R. , Lanza Elaine , Colburn Nancy H. 
Published: January 2009

Abstract
Although inflammatory cytokines and obesity-associated serum proteins have been reported as biomarkers of colorectal adenoma risk in humans, little is known of biomarkers of response to interventions that attenuate tumorigenesis. Dietary navy beans and their fractions attenuate colon carcinogenesis in carcinogen-induced genetically obese mice. We hypothesized that this attenuation would be associated with changes in inflammatory cytokines and obesity-related serum proteins that may serve as measures of efficacy. ob/ob mice (n = 160) were injected with the carcinogen azoxymethane (AOM) to induce colon cancer and randomly placed on one of four diets (control, whole navy bean, bean residue fraction, or bean extract fraction) for 26 to 28 wk. Serum was analyzed for 14 inflammation- or obesity-related proteins, and colon RNA was analyzed for expression of 84 inflammation-associated genes. Six of 14 serum proteins were increased [i.e., interleukin (IL)-4, IL-5, IL-6, IL-10, IFNγ, granulocyte macrophage colony-stimulating factor] in hyperplastic/dysplastic stages of colon carcinogenesis. Bean-fed mice had significantly higher monocyte chemoattractant protein-1 and lower IL-6 levels in serum. In colon mucosa, 55 of 84 inflammation-associated genes differed between AOM-induced and noninduced mice. Of the 55 AOM-induced genes, 5 were counteracted by bean diets, including IL-6 whose increase in expression levels was attenuated by bean diets in AOM-induced mice. In summary, IL-6 emerged as a serum protein that was increased in hyperplastic/dysplastic stages of colon carcinogenesis, but attenuated with bean-based diet in serum and colon mucosa. Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis.
Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity
Authors: Protiva Petr , Cross Heide S. , Hopkins Michael E. , Kállay Enikö , Bises Giovanna , Dreyhaupt Eleanor , Augenlicht Leonard , Lipkin Martin , Lesser Martin , Livote Elayne , Holt Peter R. 
Published: January 2009

Abstract
Postmenopausal hormone replacement therapy lowers colon cancer incidence. In humans, the mechanism is unknown, but animal models suggest that it may involve activation of the vitamin D receptor (VDR) pathway.
The aims of our study were to determine whether estrogen intervention affects global gene expression in rectal mucosal biopsies and whether vitamin D–related genes are affected.
Estradiol was given to raise serum estradiol to premenopausal levels in 10 postmenopausal women under close nutritional control. Primary end points were expression of VDR, CYP24A1, CYP27B1, and E-cadherin in rectal mucosa by reverse transcription-PCR and examining response to estradiol by genome-wide arrays. Responses in gene expression in rectal biopsies to estrogen were determined in each subject individually and compared with a human estrogen response gene array database and a custom array in vitro–generated database.
Cluster analysis showed that subjects maintained their overall gene expression profile and that interindividual differences were greater than intraindividual differences after intervention. Eight of 10 subjects showed significant enrichment in estrogen-responsive genes. Gene array group analysis showed activation of the VDR pathway and down-regulation of inflammatory and immune signaling pathways. Reverse transcription-PCR analysis showed significant up-regulation of VDR and E-cadherin, a downstream target of vitamin D action.
These data suggest that the chemopreventive action of hormone replacement therapy on colon neoplasia results, at least in part, from changes in vitamin D activity. Evaluation of gene arrays is useful in chemopreventive intervention studies in small groups of subjects.
Regioselective and Quantitative Modification of Cellulose to Access Cellulose-based Advanced Materials: Cellulose-based Glycoclusters
Authors: Yamashita Erika , Okubo Kiyomi , Negishi Kaori , Hasegawa Teruaki 
Published: January 2009

Abstract
Regioselective and quantitative introduction of multiple β-lactoside modules onto the 6C-position of cellulose was achieved through regioselective bromination/azidation of cellulose and the following Cu+-catalyzed chemoselective coupling with alkyne-functionalized β-lactoside. The resultant cellulose-based glycocluster has good water solubility and selective lectin affinity.
Fine-tuning Cavity Size and Wall Thickness of Silica Hollow Nanoparticles by Templating Polymeric Micelles with Core–Shell–Corona Structure
Authors: Liu Dian , Khanal Anil , Nakashima Kenichi , Inoue Yuko , Yada Mitsunori 
Published: January 2009

Abstract
Hollow silica nanospheres have been successfully prepared by templating the polymeric micelles of poly(styrene-b-2-vinylpyridine-b-ethylene oxide) (PS–PVP–PEO), which shows a core–shell–corona structure in aqueous solutions. In this template, each block has its own function; the PS block (core) works as a template of the void space of hollow silica, the PVP block (shell) acts as a reaction field for the sol–gel reaction of silica precursor, and the PEO block (corona) stabilizes the polymer/silica composite particles. It was found that the diameter of the void space of the hollow silica spheres can be fine-tuned on a several nanometer scale by changing the chain length of the PS block. The wall thickness of the hollow silica is also fine-tuned by varying the concentration of the silica precursor.
An Investigation of Climate Loads on Building Façades for Selected Locations in the United States
Authors: Cornick S. M. , Lacasse M. A. 
Published: January 2009

Abstract
The ability of a wall assembly to manage rainwater and control rain penetration depends on the assembly configuration, including interface details for penetrations, and on the rain loads to which the wall is subjected. There are a variety different protocols for evaluating the ability wall systems to resist water intrusion. Generally they involve spraying varying amounts of water while maintaining a pressure difference across the specimen. Across the conterminous United States hourly weather data for extended periods (climatic data) is available for many locations. From this climatic data estimates of wind-driven rain loads can be determined. We answer the question of how often these combinations of rainfall intensities and pressure are likely to present a problem with respect to moisture management of the assembly and how often these are likely to occur over the expected life of the wall assembly. Climate information related to rainfall and wind-driven rain for Boston, Miami, Minneapolis, Philadelphia, and Seattle are provided. A methodology for generating rates of water spray impinging on and pressure differences acting across the wall assembly is also developed. Although the methodology was primarily developed to select the proper testing criteria and test conditions to mimic real events, it can also be used by designers and practitioners to: (i) determine the response of the wall assembly to the effects of wind-driven rain; (ii) estimate design loads below which adverse effects on the assembly are minimized; (iii) assess the likelihood and degree of damage to the assembly when design loads are exceeded; (iv) estimate the long-term performance of the wall assembly based on watertightness and moisture management the wall assembly.
Magnetism of free and supported clusters: a comparative study
Authors: Å ipr OndÅ™ej , MinÃ¡r JÃ¡n , Ebert Hubert 
Published: January 2009

Abstract
The presented work investigates the differences in magnetic properties of free and supported clusters via ab-initio calculations. The electronic structure of the clusters was calculated using a spin polarized relativistic multiple-scattering Greenâ€™s function formalism. We focus on Fe clusters of 2â€“9 atoms, either free or supported by Ni(001), and on Co clusters of 2â€“7 atoms, either free or supported by Au(111). For the supported clusters, the spin and orbital magnetic moments depend on the cluster size nearly monotonically, while for the free clusters large quasi-oscillations of magnetic moments with the cluster size were observed. Similarly, for supported clusters, the local spin magnetic moments decrease nearly linearly with increasing coordination number, while for free clusters of the same size range the trend is much more complicated. These findings are consistent with the fact that the spectral distribution function contains much sharper features for free clusters than for supported clusters.
Lindsaeoid ferns of Bangladesh
Authors: Mirza Momtaz Mahal 
Published: January 2009

The paper deals with two genera of the family Lindsaeaceae, namely, Lindsaea (with 4 species, L. ensifolia, L. odorata, L. lucida and L. doryphora) and Sphenomeris (with only S. chinensis) from Bangladesh. Key words: Lindsaeoid ferns, Pteridophyte, Bangladesh DOI: 10.3329/bjpt.v12i2.599 Bangladesh J. Plant Taxon. 12(2): 11-18, 2005 (December)
Hydrobiological studies within the tea gardens at Srimangal, Bangladesh. IV. Desmids (17 genera)
Authors: Islam AKM Nurul , Irfanullah Haseeb Md 
Published: January 2009

Fifty nine taxa of desmids under 17 genera, namely Cylindrocystis, Netrium, Spirotaenia, Gonatozygon, Penium Closterium, Pleurotaenium, Triploceras, Triplastrum, Hyalotheca, Groenbladia, Bambusina, Teilingia, Sphaerozosma, Spondylosium, Onychonema and Desmidium have been recorded from different aquatic habitats located within the tea gardens at Srimangal, Maulvi Bazar. Eight taxa are described as new records for Bangladesh including two genera, namely, Cylindrocystis and Spirotaenia. Key words Desmids, acidic habitats, phytoplankton, new records DOI: 10.3329/bjpt.v12i2.602 Bangladesh J. Plant Taxon. 12(2): 49-62, 2005 (December)
Three new records of Aroids (Araceae) for Bangladesh
Authors: Ara Hosne , Hassan Md Abul 
Published: January 2009

Three aroid species, namely Colocasia gigantea (Blume) Hook. f., Epipremnum pinnatum (L.) Engl. and Scindapsus perakensis Hook. f. under the family Araceae are recorded for the first time for Bangladesh. An updated nomenclature including important synonyms, illustrated descriptions, flowering and fruiting times, specimens examined, ecology, geographical distribution, occurrance within Bangladesh and uses for each species have also been provided. Key words: Colocasia gigantea, Epipremnum pinnatum, Scindapsus perakensis, New records, Araceae, Bangladesh DOI: 10.3329/bjpt.v13i2.581 Bangladesh J. Plant Taxon. 13(2): 83-91, 2006 (December)
Some tribal medicinal plants of Chittagong Hill Tracts, Bangladesh
Authors: Yusuf Mohammed , Wahab MA , Yousuf Md , Chowdhury Jasim Uddin , Begum Jaripa 
Published: January 2009

A survey was carried out in different localities of Rangamati and Bandarban Districts of Bangladesh between 2001 and 2002 to document medicinal plants. A total of 69 medicinal plants under 40 families were documented during this work, which the tribal use to treat about 50 diseases. Scientific names, tribal names of the plants, parts used, names of the diseases and names of the user communities are mentioned. Key words: Hill Tracts, Medicinal plants, Traditional knowledge, Bangladesh DOI: 10.3329/bjpt.v14i2.531 Bangladesh J. Plant Taxon. 14(2): 117-128, 2007 (December)
Design and Implementation of a Web‐Based System for Intraoperative Consultation
Authors: Tamariz Francisco , Merrell Ronald , Popescu Irinel , Onisor Daniel , Flerov Y. , Boanca Cosmin , Lavrentyev Vladimir , Rafiq Azhar 
Published: January 2009

AbstractBackgroundWith the use of electronic information distribution and telecommunication technologies, surgical teleconsultation is possible as a vehicle for consulting with experts remotely without their physical presence in the operating room (OR). This study evaluated real‐time teleconsultation from the OR to remote consultants in the Russian Research Center of Surgery, Moscow, Russia and the Fundeni Clinical Hospital, Bucharest, Romania.MethodsWe evaluated the effectiveness of teleconsultation using a secure website interface where consultants could navigate through multimedia‐based electronic documentation of a surgical procedure and identify the anatomic landmarks underlying the need for consultation. Additionally, management of a remote camera view by consultants was evaluated.ResultsFifteen thyroidectomies and parathyroidectomies were studied to confirm by teleconsultation the identity of 22 recurrent laryngeal nerves (RLNs). There was no Internet connectivity interruption or dropped signal, and the bandwidth was consistently greater than 1 Mbps. Consultants spent an average of 6 min to review an average of 35 min of surgical records to identify the 22 RLNs.ConclusionsThis study validated a system for real‐time teleconsultation using web‐based surgical records. In addition, the ability of the consultant to manage the camera view remotely without interrupting the surgical procedure was confirmed.
The Emergence of Dalton's Chemical Atomic Theory: 1801-08
Authors: Thackray Arnold W. 
Published: January 2009

The slow emergence of Dalton's chemical atomic theory has long been a considerable puzzle to historians of science The lengthy delay between Dalton's early work on mixed gases (September 1801) and particle weights (September 1803) and the eventual publication of the first part of hisNew System of Chemical Philosophy(June 1808) has called forth a variety of explanations. It is now more than half a century since A. N. Meldrum stressed“…the efforts Dalton had to make, in order to arouse attention to the importance of his ideas regarding atoms. For some nine years (1801-1810), if not longer, he endeavoured to spread abroad his ideas, both by private communications and publicly, by his writings and by lectures in various parts of the country…“Dalton's chemical theory was formed by the 6th September 1803, and he proceeded forthwith to extend and apply it, and make it known in every direction…”And though Meldrum's view is now no longer accepted, no systematic and detailed account of Dalton's activities over these years is available to replace Meldrum's assertions.