bluuebunny/crossref_metadata_2025_split huggingface dataset:
A synthetic entry into the 2‐ and 3‐substituted‐methyl 2,3‐dihydro‐1,4‐benzoxazine series
Authors: Potter G. W. H. , Monro A. M. 
Published: March 2009

AbstractNmr spectroscopy has been used to demonstrate that the reported preparation of supposed 3‐bromomethyl‐2,3‐dihydro‐1,4‐benzoxazine (3) is in error, the product of the reaction being in reality a monocyclic compound, 4. An alternative entry to the 3‐substituted series is described in the synthesis of the 3‐hydroxymethyl derivative, 10, the structure of which was established by nmr and mass spectroscopy. The previous assignment of structure to 2‐carbethoxy‐2,3‐dihydro‐1,4‐benzoxazine, prepared by an ambiguous route, and to compounds derived from this ester, is shown to be correct.
Synthesis of some binaphthoxazoles
Authors: Kaempfen H. X. 
Published: March 2009

AbstractFour of the six possible 2,2′‐binaphthoxazoles, as well as several of their cyano derivatives, have been prepared. Naphth[2,3‐d]oxazole was synthesized for the first time and 2,2′‐binaphth‐[2,3‐d]oxazole was made using a previously reported technique in which an incorrect assumption was made.
N,N'‐bis(substituted phenyl)‐1,2,4,5‐benzenetetracarboxylic‐1,2:4,5‐diimides
Authors: Mosher William A. , Chlystek Stanley J. 
Published: March 2009

AbstractThe preparation of N,N'‐bis(substituted phenyl)‐1,2,4,5‐benzenetetracarboxylic‐1,2:4,5‐di‐imides by the reaction of 1,2,4,5‐benzenetetracarboxylic‐1,2:4,5‐dianhydride (1) with aryl‐amines and with aryl isocyanates is described. Correlations are made between the properties of these diimides and the nature and position of the substituents in the phenyl ring. The condensation of dianhydride 1 with diisocyanates yields polymers varying from soft elastomers to tough films, depending upon the amount of imide structure in the polymer chain.
Some observations on märkl's cyclic phosphonium salt synthesis. The synthesis of a phosphocane
Authors: Marsi Kenneth L. , Lynch Donald M. , Homer G. David 
Published: March 2009

AbstractMärkl's cyclic phosphonium salt synthesis was studied and some mechanistic conclusions drawn. The reaction was found to be generally applicable to the synthesis of C‐methylated five‐, six‐, seven‐ and eight‐membered ring systems. The first authenticated synthesis of a phosphocane is reported.
The crystal and molecular structure of 2,5‐dichloro‐3‐methoxypyrazine
Authors: Carter D. R. , Boer F. P. 
Published: March 2009

AbstractA three‐dimensional X‐ray structure determination of 2,5‐dichloro‐3‐methoxypyrazine has been completed with diffractometer data. The crystals are monoclinic, space group P21/c, with lattice constants a = 4.059, b = 15.773, c = 11.123Å and β = 90.96° (Z = 4). The structure was solved by Sayre's equation and all hydrogen atoms were located by difference synthesis. Full‐matrix least‐squares refinement of all position parameters, hydrogen isotropic temperature factors, and anisotropic temperature factors for all other atoms converged at R = 5.7% for the 1397 reflections above background. Bond distances and angles are consistent with literature values.
The crystal and molecular structure of 3,5‐Di‐(t‐butyl)‐1‐phenylphosphoryl‐4‐aza‐2,5‐cyclohexadiene
Authors: Hungerford Lynn , Trefonas L. M. 
Published: March 2009

AbstractThe crystal and molecular structure of the title compound (C18H26NOP) has been determined by a single crystal, x‐ray diffraction study using Cu‐Kα. radiation. The compound was found to crystallize in the orthorhombic space group Pnma with unit cell constants a = 12.686 ± .001 Å, b = 14.776 ± .001 Å, and c = 9.540 ± .001 Å. The structure was solved by the heavy atom method and refined by block‐diagonal least‐squares to a final R = 0.099 for the 696 statistically significant reflections. The compound exhibits orientational disorder in the crystalline state. Nevertheless, the planarity of this ring; the lengthening of the diene carbon‐carbon bond to 1.41 Å the resultant shortening of both the carbon‐nitrogen bond (1.43 Å) and the carbon‐phosphorus bond (1.74 Å), and the CNC bond angle of 121° all strongly support the assumption of delocalization of the diene π‐electrons within the heterocyclic ring system.
Hypocholesterolemic alkaloids of lentinus edodes (berk.) sing. II. A novel synthesis of eritadenine
Authors: Kamiya T. , Saito Y. , Hashimoto M. , Seki H. 
Published: March 2009

AbstractA novel and convenient method for the synthesis of eritadenine (I) was established. Direct condensation of adenine and 2,3‐O‐isopropylidene‐D‐erythronolactone (II) under basic condition, followed by removal of the protecting group, afforded eritadenine (I) in fairly good yield, with accompany of a small amount of the N3‐isomer (VI). A similar reaction of adenine 1‐oxide gave exclusively eritadenine oxide (VII), which was catalytically reduced to give eritadenine (I). This procedure also provided pyrimidinyl derivatives (VIII, IX and X) corresponding to cytosine, uracil, and thymine.
Solvent effects on the tautomeric equilibria of 4,4/5,5‐disubstituted 4H/5H‐imidazol‐5/4‐ones
Authors: Edward J. T. , Lantos I. 
Published: March 2009

AbstractThe tautomerism of 4,4/5,5‐disubstituted 4H/5H‐imidazol‐5/4‐ones has been investigated by ir, uv, and pK studies. In nonpolar solvents the non‐conjugated tautomer predominates, but in polar solvents varying amounts of the conjugated tautomer may also be observed. The proportion of conjugated tautomer is increased by the presence of electron‐releasing groups at the 2‐position.
Infrared and mass spectra of purine and substituted dihydropurines
Authors: Connolly John S. , Linschitz Henry 
Published: March 2009

AbstractInfrared spectra (potassium bromide) of purine, 7 (9)‐deuteriopurine, 6‐deuteriopurine, 8‐deuteriopurine and a number of substituted dihydropurines are presented. The latter compounds are the 6‐α‐hydroxyalkyl‐1,6 (or 3,6)dihydropurines formed by photoaddition of the respective alcohols to purine (4‐6). From the comparative spectra of purine and its mono‐deuterated derivatives, it is possible to make assignments of N‐H and N‐D stretching vibrations and tentative assignments of C‐H deformation modes. The spectra of the substituted dihydropurines show evidence of interesting hydrogen‐bonding interactions which are demonstrated most clearly in the distinct differences between the spectra of the diastereomeric purine‐ethanol adducts. Mass spectra of these compounds all indicate progressive scission of HCN molecules from the principal radical‐ion. In the case of the photo‐adducts, HCN scission is preceded by scission at the site (i.e. 6‐position) of alcohol addition to the purine ring.
A short synthesis of 4‐aryioxymethyl‐δ3‐chromenes and 3‐(β‐aryloxy)ethylbenzofurans
Authors: Majumdar K. C. , Thyagarajan B. S. 
Published: March 2009

AbstractA direct and short route to the synthesis of 4‐aryloxymethyl‐δ3 ‐chromenes and 3‐(β‐aryloxy)‐ethylbenzofurans is described. Hydration of I,4‐diaryloxy‐2‐butynes with mercuric oxide and sulfuric acid affords, instead of a ketone, the cyclization product of the ketone. In three of the diaryloxy‐butynes studied, the corresponding aryloxyethylbenzofurans are formed. In no instance could the ketone be isolated from the hydration reaction.
The rearrangement of 4‐hydroxyeoumarin carbamates
Authors: Kraemer J. F. , Lira E. P. 
Published: March 2009

AbstractCarbamate esters of 4‐hydroxycoumarin were prepared, and their base‐catalyzed and thermal rearrangement to 3‐(N‐substituted carbamoy])‐4‐hydroxycoumarins were studied. A mechanism for the rearrangement is proposed.
Mass spectra of some tropane and tropidine derivatives
Authors: Dewhurst J. Elton , Kaminski J. J. , Supple J. H. 
Published: March 2009

AbstractFragmentation patterns of tropane and tropidine derivatives have been shown to depend on the nature of the substituents. Unsaturation in the 6‐membered ring leads to preferential fragmentation of the two carbon bridge. When the 6‐membered ring is saturated and substituted with poor leaving groups (OH and CN) fragmentation of the 6‐membered ring is preferred.
The synthesis of some 5‐methoxypyrimidine nucleosides
Authors: Stout M. G. , Robins R. K. 
Published: March 2009

AbstractThe synthesis of 5‐methoxyuridine (3), 5‐methoxycytidine (6), 1‐(2‐deoxy‐β‐D‐erythropento‐furanosyl)‐5‐methoxyuracil (14), 5‐methoxy‐1‐β‐D‐ribofuranosyl‐4‐thiopyrimidin‐2‐one (5), 1‐β‐D‐arabinofuranosyl‐5‐methoxycytosine (12), 1‐β‐D‐arabinofuranosyl‐5‐methoxyuracil (8) and 1‐β‐D‐arabinofuranosyl‐5‐methoxy‐4‐thiopyrimidin‐2‐one (11) have been accomplished. Both3and14were synthesized by alkylation of 2,4‐bis(trimethyIsilyI)‐5‐methoxyuracil (1) with the appropriately blocked halosugars. Synthesis of the corresponding 5‐methoxy‐1‐β‐D‐arabinofuranosyl derivatives was accomplished through the intermediate 2,2 ‐anhydro‐1‐β‐D‐arabinofuranosyl‐5‐methoxyuracil (7). The cytosine and 4‐thiouracil derivatives in both the arabino‐ and ribo‐ series were prepared by thiation followed by amination.
Spectra and photolysis of the 1‐oxides of the pyridinecarboxylic acids and pyridinecarboxamides
Authors: Caswell Lyman R. , Lee Florence C. , Creagh Linda T. 
Published: March 2009

AbstractThe ultraviolet absorption spectra of aqueous and alcoholic solutions of the pyridinemono‐carboxylic acids and amides, of the vicinal pyridinedicarboxylic acids, and of the 1‐oxides of these compounds, were measured and qualitatively interpreted. The photolysis of the 1‐oxides in aqueous solution resulted principally in their deoxygenation. Photolysis of picolinamide 1‐oxide also gave a rearrangement product, 1‐formyl‐2‐pyrrolecarboxamide. The photolyses of the 2‐ and 4‐monosubstituted 1‐oxides were somewhat faster than those of the 3‐substituted 1‐oxides. The experimental results are discussed in terms of possible hydrogen‐bonding effects.
Cyclic hydroxamic acids derived from quinazoliue
Authors: Schapira Celia B. , Lamdan Samuel 
Published: March 2009

AbstractThe action of various acylating agents on 2‐aminobenzohydroxamic acid afforded 3‐hydroxy‐4(3H)quinazolinones (hydroxamic acids) as well as several ethers and esters from them were prepared and their spectroscopic properties analyzed. Secondary amines, as well as one equivalent of alkali, on 2‐halomethyl‐3‐hydroxy‐4(3H)quinazolinone lead to the formation of a dimer(XI). In this respect the behaviour of secondary amines is different from that of primary amines. Some new 3‐hydroxy‐2‐4(1H,3H)‐quinazolidinediones are described.
Synthesis and structure of some asymmetrically substituted furoxans. I
Authors: Gasco A. , Mortarini V. , Ruà G. , Nano G. M. , Menziani E. 
Published: March 2009

AbstractFrom the mixture of isomeric esters obtained by heating 3‐methy 1‐4‐furoxancarboxylie acid ethyl ester, some furoxan derivatives have been prepared; their structures were assigned on the basis of nmr spectroscopy.
A new synthesis of s‐triazoles from 1H‐2,3‐benzoxazine 4‐hydrazones
Authors: Pifferi G. , Consonni P. 
Published: March 2009

AbstractAliphatic and aromatic aldehydes react with 4‐hydrazino‐1H‐2,3‐benzoxazines (I) to form the corresponding 1H‐2,3‐benzoxazine hydrazones (II). Compounds II when heated in the presence of an acid catalyst rearrange to form substituted s‐triazoles (III) in high yields. In particular, the hydrazones containing one imino hydrogen undergo the same rearrangement by refluxing in xylene. Structure III, in agreement with the analytical and spectroscopic data, was confirmed by univocal syntheses. The N‐acylation and N‐alkylation of some unsymmetrically 3,5‐sub‐stituted s‐triazoles were also investigated and the mechanism of formation of III is briefly discussed.
The synthesis of 2‐azainosine and related derivatives by ring annulation of imidazole nucleosides
Authors: Panzica Raymond P. , Townsend Leroy B. 
Published: March 2009

AbstractThe synthesis of 7‐(β‐D‐ribofuranosyl)imidazo[4,5‐d]‐v‐triazin‐4‐one (6b, 2‐azainosine) and 5‐(β‐D‐ribofuranosyl)imidazo[4,5‐d]‐v‐triazin‐4‐one (4b) have been achieved for the first time by direct diazotization of AICA riboside (5b) and iso‐AICA riboside (3b), respectively. The conditions required for cyclization of the model methyl bases, 3a and 5a, as well as the nucleosides 3b, 5b, and 7 are described.
A reinvestigation of the structures for 5‐diazouracil, 5‐diazouridine, 5‐diazo‐2′‐deoxyuridine and certain related derivatives by proton magnetic resonance spectroscopy
Authors: Thurber T. Craig , Townsend Leroy B. 
Published: March 2009

AbstractThe structure of 5‐diazouracil and several closely related derivatives have been revised on the basis of pmr spectroscopy. 5‐Diazouracil, 5‐diazouracil hydrate, 5‐diazouracil methanol adduct, 5‐diazouridine and 5‐diazo‐2′‐deoxyuridine have been reassigned the structures 5‐diazopyrimidin‐2,4(3H)dione (XI), 5‐diazo‐6‐hydroxy‐1,6‐dihydropyrimidin‐2,4(1H,3H,6H)dione (XIII), 5‐diazo‐6‐methoxy‐1,6‐dihydropyrimidin‐2,4(1H,3H,6H)dione (XII), 1 ‐(β‐D‐ribofuranosyl)‐O5′ ‐6(S)cyclo‐5‐diazo‐1,6‐dihydropyrimidin‐2,4(3H,6H)dione (XVII) and 1‐(2‐deoxy‐β‐D‐ribofuranosyl)‐O5′ ‐6(S)cyclo‐5‐diazo‐1,6‐dihydropyrimidin‐2,4(3H,6H)dione (XIX), respectively. Treatment of XII with dimethylamine resulted in a coupling of the 5‐diazo group with dimethylamine and a concomitant rearomatization of the heterocyclic ring by expulsion of the 6‐methoxy group to furnish 5‐(3,3‐dimethyl‐1‐triazeno)uracil (XIV). A similar reaction of XIX and XVII with dimethylamine furnished the corresponding 5‐(3,3‐dimethyl‐1‐triazeno)derivatives. The effect which certain resonance hybrids of the diazo moiety may exert in reactions of the above hetero‐cycles and the assignment of S configuration at C‐6 for the nucleoside derivatives is also discussed.
Chemical and biological studies on dihydro‐s‐triazines. XVI. Nmr evidence for the formation of 2‐guanidino‐4‐methylquinazolines as anomalous byproducts in the three‐component synthesis
Authors: Rosowsky Andre , Modest Edward J. 
Published: March 2009

AbstractThe three‐component synthesis of 4,6‐diamino‐1‐aryl‐1,2‐dihydro‐2,2‐dimethyl‐s‐triazines from arylamines. cyanoguanidine, and acetone has been studied by nmr spectral analysis in trifluoro‐acetic acid solution. The presence of 2‐guanidino‐4‐methylquinazoline contaminants can be discerned clearly at concentrations as low as 1%. Arylamines most likely to give significant proportions of guanidinoquinazoline byproducts are 2‐naphthylamines and anilines containing one or more electron‐donating meta‐substituents.
Chemical and biological studies on dihydro‐s‐triazines. XVII. Modifications of the three‐component synthesis favoring the formation of 2‐guanidino‐4‐methylquinazoline byproducts
Authors: Rosowsky Andre , Nadel Marilyn K. , Modest Edward J. 
Published: March 2009

AbstractA modified three‐component reaction of arylamines, cyanoguanidine, and acetone is described, wherein formation of anomalous guanidinoquinazoline byproducts is greatly enhanced at the expense of the normal dihydro‐s‐triazines. Four new guanidinoquinazolines and four new dihydro‐s‐triazines were synthesized via this modification, starting from 2,4‐, 2,5‐, 3,4‐, and 3,5‐dimethoxyaniline. The guanidinoquinazoline to dihydro‐s‐triazine ratio was much higher with 3,4‐ and 3,5‐dimethoxyaniline than with 2,4‐dimethoxyaniline. 2,5‐Dimethoxyaniline gave an unexpectedly low yield of guanidinoquinazoline, apparently because of steric hindrance. The modified three‐component synthesis was also examined in detail with 2‐naphthylamine.
Preparation of pyrylium salts from 2‐phenyl‐5H‐phenaleno [ 1,9‐bc] pyran‐5‐one
Authors: Van Allan J. A. , Reynolds G. A. 
Published: March 2009

AbstractThe preparation of 2‐phenyl‐5H‐phenaleno[ 1,9‐bc]pyran‐5‐one (7) is described. Compound 7 undergoes reactions typical of pyrones and was therefore a useful intermediate for the preparation of pyrylium salts. Several pyrylium dyes were prepared from 7 and the long‐wavelength absorptions of these dyes were compared with those of the corresponding flavylium dyes.
Folate antagonists. 5. Antimalarial and antibacterial effects of 2,4‐diamino‐6‐(aryloxy and aralkoxy)quinazoline antimetabolites
Authors: Elslager Edward F. , Clarke Jane , Johnson Judith , Werbel Leslie M. , Davoll John 
Published: March 2009

Abstract2 Various4‐diamino‐6‐(phenoxy, naphthyloxy, and phenalkoxy)quinazolines (VIII, XIV) were synthesized for antimalarial and antibacterial evaluation. Treatment of the anion of the requisite phenol or naphthol with 5‐chloro‐2‐nitrobenzonitrile (V) gave the corresponding 2‐nitro‐5‐(phenoxy and naphthyloxy)benzonitriles (VI) (33–78%). Alternatively, alkylation of 5‐hydroxy‐2‐nitrobenzaldehyde (IX) with the appropriate phenalkyl halide afforded the 2‐nitro‐5‐(phenalkoxy)benzaldehydes (X) (27–62%), which were converted to the 2‐nitro‐5‐(phenalkoxy)benzonitriles (XII) via the intermediate oximes XI (62–87% overall). Reduction of the 2‐nitrobenzonitriles (VI, XII) with stannous chloride‐hydrochloric acid provided the corresponding 2‐amino‐5‐(phenoxy, naphthyloxy, and phenalkoxy)benzonitriles (VII, XIII) (30–83%), which upon cyclization with chloroformamidine hydrochloride gave the 2,4‐diaminoquinazolines VIII and XIV (12–85%). Against Plasmodium berghei in mice, eleven compounds were active orally at doses ranging from 6.3 to 174 mg./kg./day for 6 days, while seven substances displayed activity subcutaneously following single doses of 40–640 mg./kg. Fifteen compounds exhibited in vitro antibacterial activity against Streptococcus faecalis (MGH‐2), normal (UC‐76) and drug‐resistant (S18713) Staphylococcus aureus, Escherichia coli (Vogel), and Shigella sonnei (C‐10) with MIC's ranging from < 0.25 to 20 μg./ml. (gradient plate). Data on the inhibitory effects of representative compounds against Streptococcus faecalis R (S. faecium var. durans), S. faecalis A (amino‐pterin, methotrexate‐resistant), and Lactobacillus plantarum are presented, and overall structure‐activity relationships are discussed.
The direction of the dipole moments of furan, thiophen, and pyrrole: A controversial question
Authors: Marino Gianlorenzo 
Published: March 2009

AbstractThe report that the dipole moment in the five‐membered heterocyclic rings, furan, thiophene, and pyrrole has the positive pole on the heteroatom is contradicted with arguments based on reactivity data, theoretical calculations and moment values of substituted derivatives.In actuality, the dipole moment in furan and thiophene is directed from the ring (positive pole) to the heteroatom (negative pole).
Pyrimidine derivatives. IV. Synthesis of N1 ‐(2‐methoxy‐4‐pyrimidyl)sulfaniiamide
Authors: Okui Kiyoshi , Ito Kiyohiko , Kametani Tetsuji 
Published: March 2009

AbstractN1‐(2‐Methoxy‐4‐pyrimidyl)sulfanilamide was successfully prepared through three alternative routes. Namely, the above compound was obtained by condensation of 4‐amino‐2‐methoxy‐pyrimidine (III) with p‐acetaminobenzenesulfonyl chloride and p‐nitrobenzenesulfonyl chloride and by direct condensation with sulfanilamide.
Synthesis of 1‐(2‐ethyl‐3‐indolyl)‐1‐(3‐pyridyl)ethylene and related ellipticine analogues
Authors: Bergman Jan , Carlsson RenÉ 
Published: March 2009

AbstractIndole, 2‐methylindole, and 3‐etliylindole have been condensed with acetyl‐ and propionylpyridine, respectively. When propionylpyridine was used as the reactant, the product always was a 1‐(pyridyl)‐1‐indoly[propylene. Condensation of 2‐substituted indoles with 3‐acetylpyridine gave similar products, whereas a similar condensation with 4‐acetylpyridine gave 1,2‐bis(3‐indolyl)‐1‐(4‐pyridyl)ethanes (e.g. 7a). Condensation of unsubstituted indole with 3‐or 4‐acetylpyridine respectively, gave 1,1‐bis(3‐indolyl)‐1‐(pyridyl)ethanes (e.g. 6c).
Chemistry of thienopyridines. XV. Syntheses of thieno [3,4‐b] ‐ and thieno[3,4‐c] pyridines
Authors: Klemm L. H. , Johnson W. O. , White D. V. 
Published: March 2009

AbstractThieno [3,4‐b] pyridine (5) was synthesized by means of the successive steps of (a) photochlorination of 2,3‐dimethylpyridine to the bis(chloromethyl) compound, (b) condensation with sodium sulfide, (c) oxidation to the sulfoxide, and (d) catalytic dehydration by means of alumina. Thieno[3,4‐c]pyridine (6) was obtained in an analogous manner. Spectral properties indicate that 5 and 6 have aromatic character.
A facile synthesis of 2,3‐dihydroimidazo‐ and 1,2,3,4‐tetrahydropyrirnido[1,2‐f] phenanthridines
Authors: Pan Hsi‐Lung , Fletcher T. Lloyd 
Published: March 2009

AbstractWhen 6‐(2‐hydroxyethyl)amino‐(1), 6‐(3‐hydroxypropyl)amino‐(2),or 6‐[2‐(1‐hydroxybutyl)]‐aminophenanthridines (3), dissolved in concentrated sulfuric acid, were treated with nitrosylsulfuric acid at 0–25, then diluted with water and basified with aqueous sodium hydroxide at 65–86°, 2,3‐dihydroimidazo‐ (4a‐i), 1,2,3,4‐tetrahydropyrimido‐ (5), or 2,3‐dihydro‐2‐ethyl‐imidazo[1,2‐f]phenanthridines (4j‐p) were obtained respectively in good yields. Structures were substantiated by ir spectroscopy. The 6‐ω‐hydroxyalkylaminophenanthridines were prepared from the corresponding 6‐chlorophenanthridines. A possible mechanism for the formation of these ring systems is postulated.
Heterocycles derived from the condensation of 1,3‐propanediamine with phthalic acid derivatives
Authors: Gaozza C. H. , Grinberg H. , Lamdan S. 
Published: March 2009

AbstractThe condensation of phthalic anhydride with 1,3‐propanediamine afforded N‐(o‐carboxybenzoyl)‐1,3‐propanediamine (I) which by intravolecular cyclization was transformed into 2,3,4,6‐b‐tetrahydropyrimido[2,1‐a]isoindol‐6‐one (II) rather than the benzodiazonine (III). An intermediate in the condensation is proposed. The reaction of 1,3‐propanediamine with dimethyl phthalate also did not afford III, but rather a more complex product, dibenzo[c,l]‐1,6,10,15‐tetraazacyclooctadecane‐5,11,16,22‐tetraone (IX). Reaction of 1,3‐propanediamine with phthaloyl chloride gave 6,13‐propanodibenz[c,h]‐1,6‐diazecine‐5,7,12,14‐tetrone (XII). Spectroscopic data of the heterocycles obtained and chemical properties of II are given.
Preparation and mass spectra of 2,5‐diaryl‐1,4‐dithiins
Authors: Buess Charles M. , Brandt Vernon O. , Srivastava R. C. , Carper W. Robert 
Published: March 2009

Abstract2 Seven5‐diaryl‐1,4‐dithiins were prepared from phenacyl halides via the corresponding Bunte salts. The mass spectra showed a number of similarities within this series of compounds. Various dipositive ions were observed in all cases while the unsubstituted and p‐methyl derivatives formed tripositive ions. Ir, nmr, and chemical analysis were also completed and reported.
Benzo‐ and indoloquinolizine derivatives. I. Synthesis of 4b,5,6,7,8,8a,10,11,16,16b‐decahydrodibenz[f,h] indolo[2,3‐a] quinolizine
Authors: Van Binst G. , Tourwe D. 
Published: March 2009

AbstractTwo 4b 5,6,7,8,8a,10,11,16,16b‐decahydrodibenz[f,h]indolo‐[2,3‐a]quinolizine epimers have been synthesized starting from trans‐1,2,3,4,4a,10b‐hexahydrophenanthridine. The structural assignment of both isomers is discussed by use of ir and pmr spectroscopy.
Novel polycyclic heterocycles. IX. Dibenz[b,f] [1,4]oxazocin‐11 (12H)one, 6,11‐dihydro‐12H‐dibenz[b,f] [1,4]oxazocine, and their derivatives
Authors: Yale Harry L. , Spitzmiller Ervin R. 
Published: March 2009

AbstractDibenz[b,f][1,4]oxazocin‐11 (12H)one, 14, was synthesized by the dicyclohexylcarbodiimide induced cyclization of α‐(o‐aminophenoxy)‐o‐toluic acid (13). Reduction of 14 by lithium aluminum hydride gave 6,11‐dihydro‐12H‐dibenz[b,f][1,4]oxazocine (16). Both 14 and 16 were converted to a series of 12‐alkylated and ‐acylated derivatives. The pmr spectra of some of these compounds are discussed.
The synthesis of some purine nucleosides from 4,6‐di‐O‐acetyl‐3‐deoxy‐3‐(ethoxycarbonylamino)‐D‐glucal
Authors: Lourens Gerhardus J. , Jordaan A. 
Published: March 2009

AbstractThe acid catalyzed reaction of 4,6‐di‐O‐acetyl‐3‐deoxy‐3‐(ethoxycarbonylamino)‐D‐glucal and 6‐chloropurine in nitrometliane solution gave 6‐ehloro‐9‐(4′,6′‐di‐O‐acetyl‐2′,3′‐dideoxy‐3′‐ethoxy‐carbonylamino‐α‐ and β‐D‐arafemohexopyranosyl)purine. These were converted to the corresponding deblocked 6‐dimetliylaminopurine nucleosides by treatment with ethanolic dimethylamine; acetylation of these gave the respective 4′,6′‐di‐O‐acetyl derivatives. The anomeric assignments for the nucleosides were based on their nmr spectral data.