bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aryldithioethyloxycarbonyl (Ardec): A New Family of Amine Protecting Groups Removable under Mild Reducing Conditions and Their Applications to Peptide Synthesis
Authors: Lapeyre Milaine , Leprince Jérôme , Massonneau Marc , Oulyadi Hassan , Renard Pierre‐Yves , Romieu Anthony , Turcatti Gerardo , Vaudry Hubert 
Published: March 2006

AbstractThe development of phenyldithioethyloxycarbonyl (Phdec) and 2‐pyridyldithioethyloxycarbonyl (Pydec) protecting groups, which are thiol‐labile urethanes, is described. These new disulfide‐based protecting groups were introduced onto the ε‐amino group of L‐lysine; the resulting amino acid derivatives were easily converted into Nα‐Fmoc building blocks suitable for both solid‐ and solution‐phase peptide synthesis. Model dipeptide(Ardec)s were prepared by using classical peptide couplings followed by standard deprotection protocols. They were used to optimize the conditions for complete thiolytic removal of the Ardec groups both in aqueous and organic media. Phdec and Pydec were found to be cleaved within 15 to 30 min under mild reducing conditions: i) by treatment with dithiothreitol or β‐mercaptoethanol in Tris⋅HCl buffer (pH 8.5–9.0) for deprotection in water and ii) by treatment with β‐mercaptoethanol and 1,8‐diazobicyclo[5.4.0]undec‐7‐ene (DBU) in N‐methylpyrrolidinone for deprotection in an organic medium. Successful solid‐phase synthesis of hexapeptides Ac‐Lys‐Asp‐Glu‐Val‐Asp‐Lys(Ardec)‐NH2 has clearly demonstrated the full orthogonality of these new amino protecting groups with Fmoc and Boc protections. The utility of the Ardec orthogonal deprotection strategy for site‐specific chemical modification of peptides bearing several amino groups was illustrated firstly by the preparation of a fluorogenic substrate for caspase‐3 protease containing the cyanine dyes Cy 3.0 and Cy 5.0 as FRET donor/acceptor pair, and by solid‐phase synthesis of an hexapeptide bearing a single biotin reporter group.
Structural Variations in the Solid‐Solution Series LnxCa2‐xAl [Al1+xSi1‐xO7] with 0 ≤ x ≤ 1 and Ln: La, Eu, Er.
Authors: Peters L. , Knorr K. , Depmeier W. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Vapor Transport of Solid Solutions. Part 25. Formation of Mixed Phases and Chemical Vapor Transport in the Systems TiS2/MoS2, TiSe2/MoSe2, TaS2/MoS2 and TaSe2/MoSe2.
Authors: Hotje U. , Wartchow R. , Binnewies M. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Resolution, and Aldol Reactions of a Planar‐Chiral Lewis Acid Complex.
Authors: Liu Shih‐Yuan , Hills Ivory D. , Fu Gregory C. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Titanium‐Catalyzed Iminohydrazination of Alkynes.
Authors: Banerjee Sanjukta , Shi Yanhui , Cao Changsheng , Odom Aaron L. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Evaluation of 5‐Phenyl‐1H‐1,4‐benzodiazepin‐2(3H)‐one‐Based Palladium Complexes as Precatalysts in C—C Bond Forming Reactions.
Authors: Spencer John , Sharratt David P. , Dupont Jairton , Monteiro Adriano L. , Reis Vinicius I. , Stracke Marcelo P. , Rominger Frank , McDonald Iain M. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
tert‐Butyl (Phenylsulfonyl)alkyl‐N‐hydroxycarbamates: The First Class of N‐(Boc) Nitrone Equivalents.
Authors: Guinchard Xavier , Vallee Yannick , Denis Jean‐Noel 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Regio‐ and Enantioselective Palladium‐Catalyzed Allylic Alkylation and Amination of Dienyl Esters with 1,1′‐P,N‐Ferrocene Ligands.
Authors: Zheng Wen‐Hua , Sun Na , Hou Xue‐Long 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of N‐Substituted Isoindolinones via a Palladium‐Catalyzed Three‐Component Carbonylation—Amination—Michael Addition Cascade.
Authors: Grigg Ronald , Gai Xinjie , Khamnaen Tossapol , Rajviroongit Shuleewan , Sridharan Visuvanathar , Zhang Lixin , Collard Simon , Keep Ann 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium‐Catalyzed Cycloaddition of Alkynes and Organic Azides.
Authors: Zhang Li , Chen Xinguo , Xue Peng , Sun Herman H. Y. , Williams Ian D. , Sharpless K. Barry , Fokin Valery V. , Jia Guochen 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Azinyl Sulfides. Part 89. Synthesis and Structure of Dipyrido‐1,4‐dithiins
Authors: Morak Beata , Pluta Krystian , Suwinska Kinga , Grymel Miroslawa , Besnard Celine , Schiltz Marc , Kloc Christian , Siegrist Theo 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Transformation of Double Hydrogen‐Bonding Motifs of TTF‐Uracil System by Redox Change.
Authors: Miyazaki Eigo , Morita Yasushi , Umemoto Yoshikazu , Fukui Kozo , Nakasuji Kazuhiro 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis by Microwave Irradiation and Antidiarrhoeal Activity of Benzotriazinone and Saccharine Derivatives.
Authors: Fiorino Ferdinando , Caliendo Giuseppe , Perissutti Elisa , Severino Beatrice , Frecentese Francesco , Preziosi Barbara , Izzo Angelo A. , Capasso Raffaele , Santagada Vincenzo 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthetic Utilization of Polynitroaromatic Compounds. Part 3. Preparation of Substituted Dibenz[b,f][1,4]oxazepine‐11(10H)‐ones from 2,4,6‐Trinitrobenzoic Acid via Nucleophilic Displacement of Nitro Groups.
Authors: Samet Alexander V. , Marshalkin Victor N. , Kislyi Konstantine A. , Chernysheva Natalya B. , Strelenko Yuri A. , Semenov Victor V. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kinetic Resolution of Chiral Secondary Alcohols by Dehydrogenative Coupling with Recyclable Silicon‐Stereogenic Silanes.
Authors: Rendler Sebastian , Auer Gertrud , Oestreich Martin 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Fluorous Trialkyl Phosphines with the Complete Exclusion of PH3.
Authors: Vlad Gabor , Richter Frank U. , Horvath Istvan T. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Employment of Palladium Pincer‐Complexes in Phenylselenylation of Organohalides.
Authors: Wallner Olov A. , Szabo Kalman J. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Activity of Some 17a‐Substituted Homolactones of Androst‐5‐ene Derivatives.
Authors: Penov Gasi Katarina M. , Stojanovic Srdjan Z. , Sakac Marija N. , Djurendic Evgenija A. , Csanadi Janos J. , Molnar‐Gabor Dora , Lazar Dusan , Kovacevic Radmila M. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vinylsulfones versus Alkylsulfones in the Addition to Chiral Imines. Synthesis of N‐(tert‐Butoxycarbonyl)‐L‐homophenylalanine.
Authors: Diez David , Garcia Pilar , Marcos Isidro S. , Basabe Pilar , Garrido Narciso M. , Broughton H. B. , Urones Julio G. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convenient Preparation of Highly Active Phase‐Transfer Catalyst for Catalytic Asymmetric Synthesis of α‐Alkyl‐ and α,α‐Dialkyl‐α‐amino Acids: Application to the Short Asymmetric Synthesis of BIRT‐377.
Authors: Han Zhenfu , Yamaguchi Yukako , Kitamura Masanori , Maruoka Keiji 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile One‐Step Syntheses of Modified O‐Glycoprotein Galβ1‐3GaINAc Structures by Transglycosylation Employing Three β‐Galactosidases from Bovine Testes, Xanthomonas manihotis, and Bacillus circulans.
Authors: Kroeger Lars , Thiem Joachim 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of (.+‐.)‐Coerulescine (Ia) and a Formal Synthesis of (.+‐.)‐Horsfiline (Ib).
Authors: Chang Meng‐Yang , Pai Chun‐Li , Kung Yung‐Hua 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Deprotection of α‐Imidazole/Benzimidazole Ribonucleosides by Catalytic Carbon Tetrabromide Initiated Photolysis.
Authors: Chandra Tilak , Brown Kenneth L. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Concise Synthesis and Antiviral Activity of Novel Unsaturated Acyclic Pyrimidine Nucleosides.
Authors: Oh Chang‐Hyun , Beak Tae‐Rim , Hong Joon Hee 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biologically Active Glycosides from Asteroidea. Part 41. Isolation and Structure Determination of Glucocerebrosides from the Starfish Linckia laevigata.
Authors: Maruta Tomoki , Saito Takeshi , Inagaki Masanori , Shibata Osamu , Higuchi Ryuichi 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
BiBr3‐Initiated Cyclization—Addition Reactions: Effect of π‐Nucleophile on Oxocarbenium Ion Addition and Total Syntheses of (+)‐(S,S)‐(cis‐6‐Methyltetrahydropyran‐2‐yl)acetic Acid and Its trans‐Diastereomer.
Authors: Hinkle Robert J. , Lian Yajing , Litvinas Nichole D. , Jenkins Alex T. , Burnette Daniel C. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Corrosion Protection by Chemical Vapor Deposition: A Review
Authors: Sathiyanarayanan S. , Rajagopal G. , Palaniswamy N. , Raghavan M. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Potential of P1 Site Alterations in Peptidomimetic Protease Inhibitors as Suggested by Virtual Screening and Explored by the Use of CC‐Coupling Reagents
Authors: Weik Steffen , Luksch Torsten , Evers Andreas , Böttcher Jark , Sotriffer Christoph A. , Hasilik Andrej , Löffler Hans‐Gerhard , Klebe Gerhard , Rademann Jörg 
Published: March 2006

AbstractA synthetic concept is presented that allows the construction of peptide isostere libraries through polymer‐supported C‐acylation reactions. A phosphorane linker reagent is used as a carbanion equivalent; by employing MSNT as a coupling reagent, the C‐acylation can be conducted without racemization. Diastereoselective reduction was effected with L‐selectride. The reagent linker allows the preparation of a norstatine library with full variation of the isosteric positions including the P1 side chain that addresses the protease S1 pocket. Therefore, the concept was employed to investigate the P1 site specificity of peptide isostere inhibitors systematically. The S1 pocket of several aspartic proteases including plasmepsin II and cathepsin D was modeled and docked with ≈500 amino acid side chains. Inspired by this virtual screen, a P1 site mutation library was designed, synthesized, and screened against three aspartic proteases (plasmepsin II, HIV protease, and cathepsin D). The potency of norstatine inhibitors was found to depend strongly on the P1 substituent. Large, hydrophobic residues such as biphenyl, 4‐bromophenyl, and 4‐nitrophenyl enhanced the inhibitory activity (IC50) by up to 70‐fold against plasmepsin II. In addition, P1 variation introduced significant selectivity, as up to 9‐fold greater activity was found against plasmepsin II relative to human cathepsin D. The active P1 site residues did not fit into the crystal structure; however, molecular dynamics simulation suggested a possible alternative binding mode.
Overexpression in colorectal carcinoma of two lysosomal enzymes, CLN2 and CLN1, involved in neuronal ceroid lipofuscinosis
Authors: Tsukamoto Toshihiko , Iida Juri , Dobashi Yoh , Furukawa Taiji , Konishi Fumio 
Published: March 2006

AbstractBACKGROUNDLysosomal proteases are implicated in cancer progression and metastasis. In the current study, using subtraction cloning for genes that are differentially expressed in metastasis, the authors isolated a clone encoding ceroid lipofuscinosis, neuronal 2 (CLN2), which is a lysosomal serine protease defective in neuronal ceroid lipofuscinosis (NCL). Increased CLN2 activity has been reported in breast carcinoma and the antiapoptotic effect of another causative gene of NCL, ceroid lipofuscinosis, neuronal 1 (CLN1), is known.METHODSThe mRNA levels of CLN2, CLN1, and cathepsins B, D, H, and L were investigated in colorectal carcinoma patients with different clinical stages using real‐time quantitative reverse transcriptase polymerase chain reaction. A polyclonal antibody was raised against a recombinant CLN2 protein for immunoblotting and immunohistochemistry.RESULTSThe mRNA levels of CLN1 and cathepsins B, D, and L were significantly higher in metastatic lesions than in primary tumors. In the primary tumors, mRNA expressions of CLN2 and cathepsin D were associated with advanced clinical stages (P < .015 and P < .031, respectively). Among the lysosomal enzymes examined, only the mRNA expression of CLN2 in both the primary tumors of all patients and the pT3 tumors was correlated with the presence of liver metastases (P < .0049 and P < .029, respectively). The polyclonal antibody prepared in the current study demonstrated CLN2 overexpression by immunoblotting and immunohistochemistry.CONCLUSIONSThe results indicate that there is a close correlation between CLN2 and CLN1 expression and colorectal carcinoma progression and metastasis and suggest that they may be potential molecular targets. Cancer 2006. © 2006 American Cancer Society.
Results of postoperative reirradiation for recurrent or second primary head and neck carcinoma
Authors: Kasperts Nicolien , Slotman Ben J. , Leemans C. Rene , de Bree Remco , Doornaert Patricia , Langendijk Johannes A. 
Published: March 2006

AbstractBACKGROUNDIn this prospective study, the effects of a second course of postoperative radiation therapy on locoregional control, survival, toxicity, and quality of life were investigated in patients who underwent resection of a second primary or locoregional recurrent head and neck tumor in a previously irradiated area.METHODSIn total, 39 patients who underwent surgery for second primary tumors (n = 19 patients) or for recurrent locoregional tumors (n = 20 patients) were retreated with postoperative radiotherapy (RE‐PORT). Indications for RE‐PORT were extranodal spread (49%), positive surgical margins (44%), and/or other risk factors (8%). The target volume for RE‐PORT was confined to the high‐risk area. No elective radiotherapy was applied in regions that were situated in the formerly high‐dose area. A total dose of 46 grays (Gy) was given to elective areas with boosts from 60 Gy to 66 Gy to the high‐risk region with conventional fractionation. The results of RE‐PORT were compared with the results from patients who were treated in the same period with primary adjuvant radiotherapy (PRI‐PORT) at the authors' institution.RESULTSThe mean follow‐up was 32 months (range, 3‐84 mos). The locoregional control rate after 3 years in the RE‐PORT group was 74%, and the 3‐year overall survival rate was 44%. This did not differ significantly compared with survival rates in the PRI‐PORT group. Although a higher rate of late radiation‐induced morbidity and more head and neck symptoms were observed in the RE‐PORT group compared with the PRI‐PORT group, no differences were observed with regard to the more general dimensions of quality of life.CONCLUSIONSRE‐PORT after surgery for recurrent locoregional tumors and/or second primary tumors should be considered in patients who have high‐risk histopathologic features. Cancer 2006. © 2006 American Cancer Society.
Proteomic‐based prediction of clinical behavior in adult acute lymphoblastic leukemia
Authors: Albitar Maher , Potts Steven J. , Giles Francis J. , O'Brien Susan , Keating Michael , Thomas Deborah , Clarke Charlotte , Jilani Iman , Aguilar Christine , Estey Elihu , Kantarjian Hagop 
Published: March 2006

AbstractBACKGROUNDResponse in adult acute lymphoblastic leukemia (ALL) can be achieved in a majority of patients. However, unlike pediatric ALL, recurrence is common in adult ALL, and the ability to predict at an early stage which patients are most likely to experience recurrence may help in devising new therapeutic approaches to prevent recurrence.METHODSPeripheral blood plasma from 57 patients with confirmed ALL was obtained before induction therapy for proteomic analysis. Follow‐up continued for a median period of 71 weeks. For each plasma sample, 4 fractions eluted from a strong anion column were applied to 3 different ProteinChip array surfaces, and 12 surface‐enhanced laser desorption/ionization (SELDI) spectra were generated. Peaks that correlated with recurrence were identified and decision trees were constructed and evaluated, using only 2 peaks per predictive tree.RESULTSThe best decision trees provided strong positive prediction of recurrence, with correct predictions 84% to 92% of the time, whereas negative prediction of patients who did not experience recurrence was less robust, with 62% to 74% accuracy. Prediction of recurrence was independent of cytogenetics, bone marrow blast count, lactate dehydrogenase, β‐2‐microglobulin, or surface markers. Positive prediction of L3 morphological classification was achieved in 80% of test cases.CONCLUSIONSPeripheral blood plasma is adequate to predict clinical behavior in ALL patients irrespective of the percentage of bone marrow blasts. Proteomic analysis of plasma offers a useful approach for profiling patients with ALL. Cancer 2006. © 2006 American Cancer Society.
CD4+CD25+ regulatory T cells control the magnitude ofT‐dependent humoral immune responses to exogenous antigens
Authors: Eddahri Fouad , Oldenhove Guillaume , Denanglaire Sébastien , Urbain Jacques , Leo Oberdan , Andris Fabienne 
Published: March 2006

AbstractCD4+CD25+ T reg cells are critical for peripheral tolerance and prevention of autoimmunity. Here we show that CD4+CD25+ T reg also regulate the magnitude of humoral responses against a panel of T‐dependent antigens of foreign origin during both primary and secondary immune responses. Depletion of CD4+CD25+ T cells leads to increased antigen‐specific antibody production and affinity maturation but does not affect T‐independent B cell responses, suggesting that CD4+CD25+ T reg exert a feedback mechanism on non‐self antigen‐specific antibody secretion by dampening the T cell help for B cell activation. Moreover, we show that CD4+CD25+ T reg also suppress in vitro B cell immunoglobulin production by inhibiting CD4+CD25– T cell help delivery, and that blockade of TGF‐β activity abolishes this suppression.
Regional distribution in the fatty acids of triacylglycerols and phospholipids within soybean seeds (Glycine max L.)
Authors: Yoshida Hiromi , Kanei Sako , Tomiyama Yuka , Mizushina Yoshiyuki 
Published: March 2006

AbstractThe fatty acid distribution of triacylglycerols (TAG) and major phospholipids (PL) within soybean seeds (Glycine max L.) was investigated in relation to their tocopherol contents. The lipids extracted from four cultivars were separated by thin‐layer chromatography into seven fractions. Tocopherols were predominantly detected in the axis, followed by cotyledons and seed coat. The major lipid components were TAG and PL, while hydrocarbons, steryl esters, free fatty acids and diacylglycerols (sn‐1,3 and sn‐1,2) were also present in minor proportions. With a few exceptions, the dominant PL components were phosphatidylcholine, followed by phosphatidylethanolamine or phosphatidylinositiol. Significant differences (p <0.05) in fatty acid distribution existed when different soybean cultivars were examined. However, the principal characteristics of the fatty acid distribution in the TAG were evident among four cultivars; unsaturated fatty acids were predominantly concentrated in the sn‐2 position, and saturated fatty acids primarily occupied the sn‐1 or sn‐3 position in the oils of the soybeans.