bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and Characterization of the Anterior Loop (AL), Accessory Mental Foramen (AMF), and Lateral Lingual Foramen (LLF) Using Cone-Beam Computed Tomography in an Iranian Population
Authors: Shokri Abbas , Maleki Mohammad Mahdi , Tapak Leili 
Published: March 2024

Abstract
Objective: The presence of the anterior loop (AL), accessory mental foramen (AMF), lateral lingual foramen (LLF), and other details in the mental foramen region can complicate surgeries in this area, which may vary among different populations. This study aims to investigate these features in an Iranian population.
Materials and Methods: This cross-sectional study utilized CBCT images from patients at the Dental College of Hamadan University of Medical Sciences, encompassing 703 patients providing 1362 mandibular halves. Evaluations were conducted on various sections of CBCT images to examine the targeted structures. Data analyses were performed using IBM SPSS Statistics software (v20.0; IBM Corp) with appropriate statistical tests.
Results: The anterior loop was observed with a prevalence of 22.15% on the right side with an average length of 2.918 mm (range 1-6 mm) and 22.56% on the left side with an average length of 2.628 mm (range 0.9-5 mm). The nerve exit direction was predominantly vertical (67.27%), posterior (26.91%), and anterior (5.79%). Accessory mental foramina were present in 8.27% of cases, ranging from 1 to 3 foramina with an average count of 1.0446, where 1.51% of individuals had bilateral occurrences. Lateral lingual foramina were found in 45.6% of individuals either on the right or left side, with 24.65% having bilateral presences.
Conclusion: According to the findings, ALs, AMFs, and LLFs frequently occur in this Iranian population. Considering the impact of racial, gender, and age characteristics on the variations of these anatomical structures, it is recommended to conduct similar studies in different populations.
Analysis of risk factors and establishment of prediction model for lower extremity deep vein thrombosis after lumbar fusion surgery
Authors: Zhao Yixiang , Kong Xiangzhen , Song Kangle , Liu Zhenchuan , Zhang Yuanqiang , Cheng Lei 
Published: March 2024

Abstract
Background
Lower extremity deep vein thrombosis (LEDVT) is a common complication after orthopedic surgery. Currently, a reliable assessment tool is lacking to evaluate the risk of postoperative LEDVT in patients undergoing lumbar fusion surgery. This study aims to explore the risk factors for LEDVT formation after lumbar fusion surgery and establish a predictive model for it.
Methods
Data of patients admitted for spinal surgery from May 2022 to October 2022 were retrospectively collected. Patients were divided into DVT and non-DVT groups based on the occurrence of LEDVT after surgery. Potential risk factors were initially identified through intergroup comparative analysis and single-factor logistic regression, which were considered candidate indicators. Subsequently, the Synthetic Minority Over-sampling Technique was used to address the issue of class imbalance in the data. LASSO regression was applied to select candidate indicators, and the filtered variables were included in a multivariable logistic regression model. Nomogram and dynamic nomogram were constructed to visualize the model, and the model was subsequently validated.
Results
Factors including preoperative hospitalization days, age, gender, fibrinogen, and lower limb venous reflux/varicose vein were included in the multivariable logistic regression model. The results showed that the model had an area under the receiver operating characteristic curve of 0.803, 0.800, and 0.791 for the training set, validation set, and external validation set, respectively. Nomogram and web-based dynamic nomogram were created based on the multivariable logistic regression model. The model exhibited good performance in calibration curves and decision analysis.
Conclusion
The study identified shorter preoperative hospitalization days, age, gender, fibrinogen, and the presence of lower limb venous reflux/varicose vein as risk factors for LEDVT formation following lumbar fusion surgery. The predictive tool established based on the Logistic regression model demonstrated good performance and can be considered for assessing the risk of LEDVT formation after lumbar fusion surgery.
Solving the High-Intensity Multimodal Training Prescription Puzzle: A Systematic Mapping Review.
Authors: Sharp Tijana , Slattery Katie , Coutts Aaron J , Gogh Mikah Van , Ralph Lara , Wallace Lee 
Published: March 2024

Abstract

BackgroundHigh-Intensity Multimodal Training (HIMT) refers to all styles of high-intensity combined aerobic, resistance and/ or bodyweight exercise. Previous heterogeneity in exercise prescription and reporting in HIMT reduces the understanding of which factors should be considered when prescribing HIMT (e.g., exercise volume, intensity, duration). Previous studies have demonstrated positive effects of HIMT on health and performance outcomes. However, methodological disparities limit comparisons between findings. The objective of this systematic mapping review was to examine which prescriptive considerations and health and performance outcomes have been reported on in HIMT. This review also examined the quantity and trends of research conducted on HIMT.MethodsA systematic literature search was conducted using Ovid Medline, SPORTDiscus and Cochrane Library databases and additional sources to identify studies up until February 2023. A total of 37090 records were retrieved, of which 220 were included for review. 246 individual HIMT protocols were included for categorical analysis against the Consensus on Exercise Reporting Template (CERT) and Applied Research Model for the Sport Sciences (ARMSS).ResultsA total of 85 unique terms were used to describe HIMT. Included studies most commonly prescribed HIMT using a consistent exercise selection and circuit format. Exercise intensity was inconsistently reported on and a large proportion of studies prescribed ‘high-intensity’ exercise at a level lower than the American College of Sports Medicine criteria for high-intensity (i.e., <77% heart rate maximum). Participation location, supervision and participation format were the most commonly reported non-training variables. The most frequently reported outcomes were cardiovascular health, perceptual outcomes, body composition and biochemical outcomes. A large proportion of previous HIMT research was experimental in design.ConclusionsPrevious HIMT research demonstrates a lack of standardisation in reporting. Future studies should seek to follow guidelines (i.e., CERT) to improve reporting rigour. Additionally, forthcoming research should attempt to actively involve practitioners in implementation studies to improve ecological validity among interventions. Finally, future outcome measures should be accessible in practice and reflect common training goals of participants.RegistrationThis review adhered to PRISMA-ScR guidelines. Preregistration: osf.io/yknq4.
GALNT4 promotes the endothelial cell inflammatory response via the NF-κB signaling pathway
Authors: Guo Li Wei , Zhou Lulu , Wei Pengcheng , Li Shijie , Li Duan 
Published: March 2024

Abstract
Background
Atherosclerosis (AS) is a chronic inflammatory disease caused by dysfunction of vascular endothelial cells (ECs). Polypeptide N-acetylgalactosaminyl -transferase 4 (GALNT4) modifies target proteins via O-N-acetylgalactosamine (O-GalNAc) glycosylation, which is known to play a crucial role in regulating the inflammatory response in AS, but its exact function in ECs is yet to be determined.
Objective
This study aims to investigate the effect of GALNT4 on endothelial cell inflammation and AS.
Methods and results
We found GALNT4 expression increased in ECs exposed to pro-inflammatory stimuli. GALNT4 over-expression led to upregulation of pro-inflammatory molecules such as ICAM-1, VCAM-1, and MCP-1, which promoted the adhesion of leukocytes to ECs and trans-endothelial migration. Conversely, knockdown of GALNT4 reduced the expression of pro-inflammatory molecules induced by TNF-α. The study also observed that over-expression of GALNT4 increased the binding of NF-κB to the promoter of ICAM-1, VCAM-1, and MCP-1, while GALNT4 knockdown had the opposite effect. Additionally, GALNT4 degraded IκBα and facilitated the translocation of the NF-κB p65 subunit, thereby activating the NF-κB pathway. Finally, GALNT4-mediated endothelial cell inflammation was reduced by the NF-κB inhibitor PDTC and knockdown of the NF-κB p65 subunit, indicating that the NF-κB pathway plays a vital role in regulating GALNT4-mediated expression of adhesion molecules and chemokines.
Conclusion
We provide evidence that GALNT4 promotes the adherence of monocytes to ECs and their trans-endothelial migration via the NF-κB signaling pathway. GALNT4 could be a potential therapeutic target for AS.
Aluminum-doped carbon dots for the simultaneous selective detection of five tetracycline antibiotics
Authors: Yu Chaojie , Sun Qinxing , Wang Zongzhen , Sun Mengxue , Xu Xiang , Li Weina 
Published: March 2024

Abstract

In this paper, the aluminum-doped carbon dots (Al-CDs) were developed for simultaneous selective detection of five tetracycline antibiotics (TCs), including minocycline (MC), tetracycline (TC), oxytetracycline (OTC), doxycycline (DOC) and chlortetracycline (CTC). With the bright blue fluorescence, Al-CDs displayed excellent stability and showed no obvious fluorescence intensity changes under different ionic strength, acidic or alkaline environment, continuous ultraviolet light illumination, and even longtime storage at room temperature. As adding different antibiotics, the fluorescence of Al-CDs was strongly quenched by five TCs and showed no distinguished changes with the addition of other kinds of antibiotics. The presence of interferential metal ions, anions and small organic molecules imposed no effect on the simultaneous selective detection of five TCs. A good linear relationship was achieved for five TCs in the range of 0-100 µM, and the limit of detection (LOD) for MC, TC, OTC, DOC, and CTC were 12.70, 14.58, 14.35, 13.48 and 13.92 nM, respectively. Moreover, Al-CDs was successfully used to the detection of three TCs in real samples with recovery ranging from 92.47–122.05%, confirming a bright future for the practical applications in the assays of foods, medicines, and environments.
Childhood Outcomes Following Discharge from a Referral Bronchopulmonary Dysplasia Program
Authors: Callahan Katharine , Farrell Kathryn , Gibbs Kathleen , Kielt Matthew , Morris Heidi , Nilan Kathleen , Thomas Sarah , DeMauro Sara 
Published: March 2024

Abstract

Objectives The primary objective of this study was to profile the childhood health, development, and health-related quality of life (HR QoL) for children with the most severe bronchopulmonary dysplasia (BPD), those discharged from a quaternary referral program.Study Design : We collected cross-sectional data through telephone interviews with 282 families of children ages 18 months to 11 years who had been discharged from a BPD referral program.Results Respiratory morbidities were near universal, with 42% of children ever having required a tracheostomy and severity of these morbidities correlated with parent-reported health and QoL. Developmental morbidities were also marked: 97% required an individualized educational plan. While respiratory morbidities and overall health improved over time, developmental morbidities were increasingly prominent, resulting in lower quality of life.Conclusions Among children referred to a quaternary BPD program, respiratory and developmental morbidities are on numerous counts more severe than any reported in the literature.
Acute Toxicity of Sodium Chloride-based Road Salt Formulations to Juvenille Aquatic Invertebrates
Authors: Harwood Amanda , Wilson Hunter , John Logan St. , Centurione Isabella 
Published: March 2024

Abstract

Globally millions of tons of de-icing agents are applied each year, and about half of these salts enter surface water adjacent to sites of application. While numerous studies have demonstrated the potential impact de-icing agents such as NaCl have on freshwater invertebrates, many of these studies have used laboratory grade NaCl for evaluation, and less is known about the relative toxicity of formulations. The purpose of this study was to compare the 24 and 96 h LC50s of NaCl and two NaCl-based road salt formulations for three aquatic species: juvenile Hyalella azteca, Hexagenia rigida, and Chironomous dilutus. As expected, LC50 values were greater for 24 h exposures than 96 h exposures. However, the relative toxicity of the road salt formulations varied by exposure duration and species. Normalization for chloride ion had no effect on these relationships. Therefore, the toxicity of the road salts used in this study can be predicted based on chloride ion concentrations. Although the acute LC50 values found in this study were within environmental concentrations of chloride ions reported by existing literature, more research is needed to evaluate chronic or sublethal effects of road salt formulations on a range of freshwater macroinvertebrates.
Neutralizing GDF-15 can overcome anti-PD-(L)1 resistance in late-stage cancer
Authors: Melero Ignacio , Luken María de Miguel , de Velasco Guillermo , Garralda Elena , Liberal Juan Martin , Joerger Markus , Alonso Guzman , Goebeler Maria-Elizabeth , Schuler Martin , König David , Dummer Reinhard , Reig Mara , Rodriguez-Ruiz Maria , Calvo Emiliano , Esteban-Villarrubia Jorge , Oberoi Arjun , Sàbat Paula , Soto-Castillo Juan José , Koster Kira-Lee , Saavedra Omar , Sayehli Cyrus , Gromke Tanja , Läubli Heinz , Ramelyte Egle , Fortuny Marta , Landa-Magdalena Ana , Moreno Irene , Torres-Jiménez Javier , Hernando-Calvo Alberto , Hess Dagmar , Racca Fabricio , Richly Heike , Schmitt Andreas , Eggenschwiler Corinne , Sanduzzi-Zamparelli Marco , Vilalta-Lacarra Anna , Trajanoski Zlatko , Hackl Hubert , Gogolla Falk , Koll Florestan , Wild Peter , Chun Felix Kyoung-Hwan , Reis Henning , Lloyd Peter , Machacek Matthias , Gajewski Thomas F. , FRIDMAN Wolf , Eggermont Alexander , Bargou Ralf , Schöniger Sandra , Rüschoff Josef , Tereshchenko Anastasiia , Zink Carina , Silva Antonio da , Lichtenegger Felix , Akdemir Julia , Rüdiger Manfred , L’Huillier Phil , Dutta Aradhana , Haake Markus , Auckenthaler Alexandra , Gjorgjioska Ana , Hermann Frank , Rössler Bernhard , Liebig Mara , Schuberth-Wagner Christine , Auer Marlene , Wischhusen Jörg , Fettes Petra , Klar Kathrin , Leo Eugen 
Published: March 2024

Abstract

Cancer immunotherapies with antibodies blocking immune checkpoint molecules are active treatments across multiple cancer entities and have markedly improved cancer treatment. Yet, response rates are still limited, and tumor progression commonly occurs. Soluble and cell-bound factors in the tumor microenvironment negatively impact on cancer immunity. Recently, Growth and Differentiation-factor 15 (GDF-15), a cytokine that is abundantly produced by many cancer types, was shown to interfere with anti-tumor immune response. In preclinical cancer models, GDF-15 blockade synergistically enhanced the efficacy of anti-PD-1 mediated checkpoint inhibition. In a first-in-human phase 1/2a study (GDFATHER-1/2a trial, NCT04725474), patients with advanced cancers refractory to anti-PD-(L)1 therapy were treated with the neutralizing anti-GDF-15 antibody visugromab (CTL-002) in combination with the anti-PD-1 antibody nivolumab. Durable responses were achieved namely in patients with non-squamous non-small cell lung cancer and urothelial cancer, two cancer entities identified as frequently GDF-15 immunosuppressed in an in-silico 11,000 tumor TCGA data base screening. Increased tumor infiltrates, proliferation and Granzyme-B expression in cytotoxic T-cells were observed in response to therapy. Neutralizing GDF-15 holds promise in overcoming resistance to immune checkpoint inhibition in cancer.
Implementation of Net-Zero Energy Building in Indian Army
Authors: Rana Ashit Kumar , Ghosh Prabhat Chandra , Baswana C S 
Published: March 2024

Abstract

Net zero energy is a conceit of energy self-sufficiency that is based on minimal demand of thermal power supply and more usage of local renewable energy resources. A net zero energy military installation is defined as: ― A military installation that produces as much energy on-site from renewable energy generation or through the on-site use of renewable fuels, as it consumes in its buildings, facilities, and fleet vehicles. This study entails the green energy audit of the buildings of Indian Army aiming to identify opportunities for improving the energy efficiency of the campus and to facilitate the nation building with sustainable development. The reduction of the energy consumption while maintaining the human safety, health and comfort are of the primary importance. There is now a universal recognition of the fact that new technologies and much greater use of some that already exist provide the most hopeful prospects for the future. The opportunities lie in the use of existing renewable energy technologies, greater efforts at energy efficiency and the dissemination of these technologies and options. Achieving energy efficiency leads to net zero emission of carbon i.e., reducing the carbon footprint in the buildings and invariably reduces dependency on electricity produced by fossil fuels.
High pressure compaction and densification at 1200 ºC of nano-sized ZrO2 -3 mol% Y2O3 powders obtained by sol-gel process
Authors: Caruso Ricardo , Mamana Nadia 
Published: March 2024

Abstract
In the present work, ZrO2-3 mol% Y2O3 (Y-TZP) nanoparticles prepared by sol-gel method are incorporated in a matrix and uniaxially compacted applying different pressures. Sol-gel powders are of high reactivity, but very often the aim to obtain full densiﬁcation at low sintering temperature, is not achieved. Thus to obtain a dense pieces with these powders require a higher sintering temperature and this has a negative effect on their mechanical properties. However, if one obtains higher density of green compact favours the subsequent densification process of the final piece. In this work, to obtain the compact ones three kinds of zirconia powders are prepared in different ways. Their compaction to high pressures and sintering behaviour are studied and correlated with the densification tests. The obtained green compacts show elevated densification, small grain size and improving mechanical properties after the thermal treatment at 1200 ºC in air.
Impact of acute glycemic variability on short-term outcomes in patients with ST-segment elevation myocardial infarction: a multicenter population-based study
Authors: Wang Juan , Wang Lu-lu , Yang Yan-min , Tan Hui-qiong , Zhu Jun 
Published: March 2024

Abstract

Background
Given the increasing attention to glycemic variability (GV) and its potential implications for cardiovascular outcomes. This study aimed to explore the impact of acute GV on short-term outcomes in Chinese patients with ST-segment elevation myocardial infarction (STEMI).
Methods
This study enrolled 7510 consecutive patients diagnosed with acute STEMI from 274 centers in China. GV was assessed using the coefficient of variation of blood glucose levels. Patients were categorized into three groups according to GV tertiles (GV1, GV2, and GV3). The primary outcome was 30-day all-cause death, and the secondary outcome was major adverse cardiovascular events (MACEs). Cox regression analyses were conducted to determine the independent correlation between GV and the outcomes.
Results
A total of 7136 patients with STEMI were included. During 30-days follow-up, there was a significant increase in the incidence of all-cause death and MACEs with higher GV tertiles. The 30-days mortality rates were 7.4% for GV1, 8.7% for GV2 and 9.4% for GV3 (p = 0.004), while the MACEs incidence rates was 11.3%, 13.8% and 15.8% for the GV1, GV2 and GV3 groups respectively (p < 0.001). High GV levels during hospitalization were significantly associated with an increased risk of 30-day all-cause mortality and MACEs. When analyzed as a continuous variable, GV was independently associated with a higher risk of all-cause mortality (hazard ratio [HR] 1.679, 95% confidence Interval [CI] 1.005–2.804) and MACEs (HR 2.064, 95% CI 1.386–3.074). Additionally, when analyzed as categorical variables, the GV3 group was found to predict an increased risk of MACEs, irrespective of the presence of diabetes mellitus (DM).
Conclusion
Our study findings indicate that a high GV during hospitalization was significantly associated with an increased risk of 30-day all-cause mortality and MACE in Chinese patients with STEMI. Moreover, acute GV emerged as an independent predictor of increased MACEs risk, regardless of DM status.
Review And Improvements on Star Identification Algorithm Based On Singular Value Decomposition
Authors: Zahednamazi Mona , Toloei Alireza , Toloei Mohammad Hossein 
Published: March 2024

Abstract
The star sensor is the most accurate attitude determination sensor for space applications. This sensor determines the attitude by capturing the image of the stars in the field of view. Attitude calculation by the star sensor consists of several algorithms. Among them, star identification is the most crucial one; Because the failure of the correct star identification leads to a False attitude. One of the less discussed star identification algorithms is based on using the singular value decomposition of a matrix consisting of directional vectors of the star cluster. This paper, provides a review of some star identifications based on this concept as well as the simulation, analysis, and improvement of these methods. Moreover, the effect of various numbers of stars in the cluster as well as various fields of view size on this algorithm have been studied for different methods. The identification has been considered a two-step process based on singular values and singular vectors. Also, the rate of duplicate sets in the database of different methods has been investigated. In the last part of the paper, new methods for removing the dimmer stars in the image and bright star selection based on characteristics of singular value decomposition of the image have been proposed.