bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing parent-child interaction during wordless book reading, print book reading and imaginative play
Authors: Mathers Sandra J. , Hodgkiss Alex , Kolancali Pinar , Booton Sophie A. , Wang Zhaoyu , Murphy Victoria A. 
Published: March 2024

AbstractThis study investigated differences in adult-child language interactions when parents and their three-to-four-year old children engage in wordless book reading, text-and-picture book reading and a small-world toy play activity. Twenty-two parents recorded themselves completing each activity at home with their child. Parent input was compared across contexts, focusing on interactive and conceptual domains: use of open prompts, expansions or extensions of children’s utterances, and use of decontextualised (abstract) language. Use of linguistic expansions was greater during book reading than toy play. Parents used open questions and added contingent conceptual information more often when reading wordless books than in both other conditions. Findings suggest that wordless books may combine the benefits of open-endedness and linguistic content based around a narrative. Parents’ use of abstract language also varied by condition. This study extends understanding of the role of activity context in shaping children’s language learning environments.
Annual risk of hepatitis E virus infection and seroreversion: Insights from a serological cohort in Sitakunda, Bangladesh
Authors: Dighe Amy , Khan Ashraful Islam , Bhuiyan Taufiqur Rahman , Islam Md Taufiqul , Khan Zahid Hasan , Khan Ishtiakul Islam , Hulse Juan Dent , Ahmed Shakeel , Rashid Mamunur , Hossain Md Zakir , Rashid Rumana , Hegde Sonia T. , Gurley Emily S. , Qadri Firdausi , Azman Andrew S. 
Published: March 2024

Abstract
Hepatitis E virus (HEV) is a major cause of acute jaundice in South Asia. Gaps in our understanding of transmission are driven by non-specific symptoms and scarcity of diagnostics, impeding rational control strategies. In this context, serological data can provide important proxy measures of infection. We enrolled a population-representative serological cohort of 2,337 individuals in Sitakunda, Bangladesh. We estimated the annual risks of HEV infection and seroreversion both using serostatus changes between paired serum samples collected 9 months apart, and by fitting catalytic models to the age-stratified cross-sectional seroprevalence. At baseline, 15% (95 CI: 14–17%) of people were seropositive, with seroprevalence highest in the relatively urban south. During the study, 27 individuals seroreverted (annual seroreversion risk: 15%, 95 CI: 10–21%), and 38 seroconverted (annual infection risk: 3%, 95CI: 2–5%). Relying on cross-sectional seroprevalence data alone, and ignoring seroreversion, underestimated the annual infection risk five-fold (0.6%, 95 CrI: 0.5–0.6%). When we accounted for the observed seroreversion in a reversible catalytic model, infection risk was more consistent with measured seroincidence. Our results quantify HEV infection risk in Sitakunda and highlight the importance of accounting for seroreversion when estimating infection incidence from cross-sectional seroprevalence data.
Assessing aerial biodiversity over Keller Peninsula, King George Island, Maritime Antarctica, using DNA metabarcoding
Authors: Câmara Paulo E.A.S. , Stech Michael , Convey Peter , Šantl-Temkiv Tina , Pinto Otavio Henrique Bezerra , Bones Fábio Leal Viana , Lopes Fabyano Alvares Cardoso , Costa Rodrigues Luiz Antônio Da , Carvalho-Silva Micheline , Rosa Luiz Henrique 
Published: March 2024

AbstractAntarctic ice-free areas are dominated by wind-dispersed organisms. However, which organisms arrive and circulate in Antarctica and how remain poorly understood. Due to their proximity to South America and less extreme conditions, the South Shetland Islands are likely to receive higher diaspore numbers. One possible consequence of climate change is that newcomers will be able to colonize ice-free areas, altering community compositions and impacting the native biota. We used DNA metabarcoding to identify non-fungal eukaryotic DNA present in the air that could potentially reach and circulate in Antarctica. Air was sampled near the Brazilian Comandante Ferraz Antarctic Station on King George Island between December 2019 and January 2020. Sequences representing a total of 35 taxa from 10 phyla and 3 kingdoms were assigned: Chromista (Ciliophora, Cercozoa, Haptophyta and Ochrophyta), Plantae (Chlorophyta, Bryophyta and Magnoliophyta) and Animalia (Mollusca, Arthropoda and Chordata). The most diverse group were the plants (26 taxa), followed by Chromista (6 taxa). The most abundant sequences represented the green algae Chlamydomonas nivalis. The two angiosperm sequences represent exotic taxa; Folsomia is also exotic and was recorded only on Deception Island. Metabarcoding revealed the presence of previously undocumented airborne diversity, suggesting that the Antarctic airspora includes propagules of both local and distant origin.
Catchwater colonialism: reshaping Hong Kong’s hydrology, infrastructure, metabolism and landscape, 1937–1968
Authors: Greatrex Jack , Mok Florence 
Published: March 2024

AbstractThis article explores the development of hydrological infrastructure in colonial Hong Kong between the late 1930s and the late 1960s. Utilizing archival sources in Hong Kong and London, it shows how this infrastructure fundamentally reshaped Hong Kong’s geography. By way of concrete catchwaters and metal pipes, both ‘green’ and ‘urban’ Hong Kong became counter-intuitively interconnected. This interconnection created both unintended consequences and novel opportunities for colonial governance, driving forward natural conservation, state intervention into rural society and the development of new carceral institutions. Exploring these developments provides pivotal insight into the urban history of Hong Kong, with implications for global studies of historical urban political ecology.
An acceleration method employing sparse sensing matrix for fast analysis of the wide-angle electromagnetic problems based on compressive sensing
Authors: Qi Qi , Cao Xinyuan , Liu Yi , Kong Meng , Kuang Xiaojing , Chen Mingsheng 
Published: March 2024

AbstractThe electromagnetic scattering problem over a wide incident angle can be rapidly solved by introducing the compressive sensing theory into the method of moments, whose main computational complexity is comprised of two parts: a few calculations of matrix equations and the recovery of original induced currents. To further improve the method, a novel construction scheme of measurement matrix is proposed in this paper. With the help of the measurement matrix, one can obtain a sparse sensing matrix, and consequently the computational cost for recovery can be reduced by at least half. The scheme is described in detail, and the analysis of computational complexity and numerical experiments are provided to demonstrate the effectiveness.
Routes to diagnosis for hepatocellular carcinoma patients: predictors and associations with treatment and mortality
Authors: Burton Anya , Wilburn Jennifer , Driver Robert J. , Wallace David , McPhail Sean , Cross Tim J. S. , Rowe Ian A. , Marshall Aileen 
Published: March 2024

Abstract
Background
Hepatocellular carcinoma (HCC) incidence has increased rapidly, and prognosis remains poor. We aimed to explore predictors of routes to diagnosis (RtD), and outcomes, in HCC cases.

Methods
HCC cases diagnosed 2006–2017 were identified from the National Cancer Registration Dataset and linked to Hospital Episode Statistics and the RtD metric. Multivariable logistic regression was used to explore associations between RtD, diagnosis year, 365-day mortality and receipt of potentially curative treatment.

Results
23,555 HCC cases were identified; 36.1% via emergency presentation (EP), 30.2% GP referral (GP), 17.1% outpatient referral, 11.0% two-week wait and 4.6% other/unknown routes. Odds of 365-day mortality was >70% lower via GP or OP routes than EP, and odds of curative treatment 3–4 times higher. Further adjustment for cancer/cirrhosis stage attenuated the associations with curative treatment. People who were older, female, had alcohol-related liver disease, or were more deprived, were at increased risk of an EP. Over time, diagnoses via EP decreased, and via GP increased.

Conclusions
HCC RtD is an important predictor of outcomes. Continuing to reduce EP and increase GP and OP presentations, for example by identifying and regularly monitoring patients at higher risk of HCC, may improve stage at diagnosis and survival.
Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death
Authors: Mantione Maria Elena , Meloni Miriam , Sana Ilenia , Bordini Jessica , Del Nero Martina , Riba Michela , Ranghetti Pamela , Perotta Eleonora , Ghia Paolo , Scarfò Lydia , Muzio Marta 
Published: March 2024

AbstractMicroenvironmental signals strongly influence chronic lymphocytic leukemia (CLL) cells through the activation of distinct membrane receptors, such as B-cell receptors, and inflammatory receptors, such as Toll-like receptors (TLRs). Inflammatory pathways downstream of these receptors lead to NF-κB activation, thus protecting leukemic cells from apoptosis. Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory drug used to treat patients with multiple sclerosis and psoriasis in which it blocks aberrant NF-κB pathways and impacts the NRF2 antioxidant circuit. Our in vitro analysis demonstrated that increasing concentrations of DMF reduce ATP levels and lead to the apoptosis of CLL cells, including cell lines, splenocytes from Eµ-TCL1-transgenic mice, and primary leukemic cells isolated from the peripheral blood of patients. DMF showed a synergistic effect in association with BTK inhibitors in CLL cells. DMF reduced glutathione levels and activated the NRF2 pathway; gene expression analysis suggested that DMF downregulated pathways related to NFKB and inflammation. In primary leukemic cells, DMF disrupted the TLR signaling pathways induced by CpG by reducing the mRNA expression of NFKBIZ, IL6, IL10 and TNFα. Our data suggest that DMF targets a vulnerability of CLL cells linked to their inflammatory pathways, without impacting healthy donor peripheral blood mononuclear cells.
PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression
Authors: Tran Thi Thanh Truc , Hung Jan-Jong 
Published: March 2024

AbstractLung cancer is the major cause of death worldwide. Activation of oncogenes or inhibition of tumor suppressors causes cancer formation. Previous studies have indicated that PTEN, as a tumor suppressor, inhibits cancer formation. In this study, we studied the role of PTEN in EGFRL858R-induced lung cancer in vivo. Interestingly, loss of PTEN increased bronchial cell hyperplasia but decreased alveolar cell hyperplasia in EGFRL858R*PTEN-/--induced lung cancer. Systematic analysis of gene expression by RNA-seq showed that several genes related to ciliogenesis were upregulated in EGFRL858R*PTEN-/--induced lung cancer and subsequently showed that bronchial ciliated cells were hyperplastic. Several critical ciliogenesis-related genes, such as Mucin5A, DNAI2, and DNAI3, were found to be regulated by NR2F1. Next, NR2F1 was found to be inhibited by overexpression of PTEN, indicating that PTEN negatively regulates NR2F1, thereby inhibiting the expression of ciliogenesis-related genes and leading to the inhibition of bronchial cell hyperplasia during EGFRL858R-induced lung cancer progression. In addition, we also found that PTEN decreased AKT phosphorylation in A549, KRAS mutant, and H1299 cells but increased AKT phosphorylation in PC9, EGFRL858R, and H1299L858R cells, suggesting that PTEN may function as a tumor suppressor and an oncogene in lung cancers with KRAS mutation and EGFR mutation, respectively. PTEN acts as a double-edged sword that differentially regulates EGFRL858R-induced lung cancer progression in different genomic backgrounds. Understanding the PTEN in lung cancer with different genetic backgrounds will be beneficial for therapy in the future.
Climate change will reduce North American inland wetland areas and disrupt their seasonal regimes
Authors: Xu Donghui , Bisht Gautam , Tan Zeli , Sinha Eva , Di Vittorio Alan V. , Zhou Tian , Ivanov Valeriy Y. , Leung L. Ruby 
Published: March 2024

AbstractClimate change can alter wetland extent and function, but such impacts are perplexing. Here, changes in wetland characteristics over North America from 25° to 53° North are projected under two climate scenarios using a state-of-the-science Earth system model. At the continental scale, annual wetland area decreases by ~10% (6%-14%) under the high emission scenario, but spatiotemporal changes vary, reaching up to ±50%. As the dominant driver of these changes shifts from precipitation to temperature in the higher emission scenario, wetlands undergo substantial drying during summer season when biotic processes peak. The projected disruptions to wetland seasonality cycles imply further impacts on biodiversity in major wetland habitats of upper Mississippi, Southeast Canada, and the Everglades. Furthermore, wetlands are projected to significantly shrink in cold regions due to the increased infiltration as warmer temperature reduces soil ice. The large dependence of the projections on climate change scenarios underscores the importance of emission mitigation to sustaining wetland ecosystems in the future.
Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform
Authors: Sturm Alexander , Jóźwiak Grzegorz , Verge Marta Pla , Munch Laura , Cathomen Gino , Vocat Anthony , Luraschi-Eggemann Amanda , Orlando Clara , Fromm Katja , Delarze Eric , Świątkowski Michał , Wielgoszewski Grzegorz , Totu Roxana M. , García-Castillo María , Delfino Alexandre , Tagini Florian , Kasas Sandor , Lass-Flörl Cornelia , Gstir Ronald , Cantón Rafael , Greub Gilbert , Cichocka Danuta 
Published: March 2024

AbstractAntimicrobial resistance (AMR) is a major public health threat, reducing treatment options for infected patients. AMR is promoted by a lack of access to rapid antibiotic susceptibility tests (ASTs). Accelerated ASTs can identify effective antibiotics for treatment in a timely and informed manner. We describe a rapid growth-independent phenotypic AST that uses a nanomotion technology platform to measure bacterial vibrations. Machine learning techniques are applied to analyze a large dataset encompassing 2762 individual nanomotion recordings from 1180 spiked positive blood culture samples covering 364Escherichia coliandKlebsiella pneumoniaeisolates exposed to cephalosporins and fluoroquinolones. The training performances of the different classification models achieve between 90.5 and 100% accuracy. Independent testing of the AST on 223 strains, including in clinical setting, correctly predict susceptibility and resistance with accuracies between 89.5% and 98.9%. The study shows the potential of this nanomotion platform for future bacterial phenotype delineation.
Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans
Authors: Jensen Daria E. A. , Ebmeier Klaus P. , Suri Sana , Rushworth Matthew F. S. , Klein-Flügge Miriam C. 
Published: March 2024

AbstractThe hypothalamus is part of the hypothalamic-pituitary-adrenal axis which activates stress responses through release of cortisol. It is a small but heterogeneous structure comprising multiple nuclei. In vivo human neuroimaging has rarely succeeded in recording signals from individual hypothalamus nuclei. Here we use human resting-state fMRI (n = 498) with high spatial resolution to examine relationships between the functional connectivity of specific hypothalamic nuclei and a dimensional marker of prolonged stress. First, we demonstrate that we can parcellate the human hypothalamus into seven nuclei in vivo. Using the functional connectivity between these nuclei and other subcortical structures including the amygdala, we significantly predict stress scores out-of-sample. Predictions use 0.0015% of all possible brain edges, are specific to stress, and improve when using nucleus-specific compared to whole-hypothalamus connectivity. Thus, stress relates to connectivity changes in precise and functionally meaningful subcortical networks, which may be exploited in future studies using interventions in stress disorders.
Pitfalls in diagnosing temperature extremes
Authors: Brunner Lukas , Voigt Aiko 
Published: March 2024

AbstractWorsening temperature extremes are among the most severe impacts of human-induced climate change. These extremes are often defined as rare events that exceed a specific percentile threshold within the distribution of daily maximum temperature. The percentile-based approach is chosen to follow regional and seasonal temperature variations so that extremes can occur globally and in all seasons, and frequently uses a running seasonal window to increase the sample size for the threshold calculation. Here, we show that running seasonal windows as used in many studies in recent years introduce a time-, region-, and dataset-depended bias that can lead to a striking underestimation of the expected extreme frequency. We reveal that this bias arises from artificially mixing the mean seasonal cycle into the extreme threshold and propose a simple solution that essentially eliminates it. We then use the corrected extreme frequency as reference to show that the bias also leads to an overestimation of future heatwave changes by as much as 30% in some regions. Based on these results we stress that running seasonal windows should not be used without correction for estimating extremes and their impacts.
Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array
Authors: Zhang Dehui , Xu Dong , Li Yuhang , Luo Yi , Hu Jingtian , Zhou Jingxuan , Zhang Yucheng , Zhou Boxuan , Wang Peiqi , Li Xurong , Bai Bijie , Ren Huaying , Wang Laiyuan , Zhang Ao , Jarrahi Mona , Huang Yu , Ozcan Aydogan , Duan Xiangfeng 
Published: March 2024

AbstractNonlinear optical processing of ambient natural light is highly desired for computational imaging and sensing. Strong optical nonlinear response under weak broadband incoherent light is essential for this purpose. By merging 2D transparent phototransistors (TPTs) with liquid crystal (LC) modulators, we create an optoelectronic neuron array that allows self-amplitude modulation of spatially incoherent light, achieving a large nonlinear contrast over a broad spectrum at orders-of-magnitude lower intensity than achievable in most optical nonlinear materials. We fabricated a 10,000-pixel array of optoelectronic neurons, and experimentally demonstrated an intelligent imaging system that instantly attenuates intense glares while retaining the weaker-intensity objects captured by a cellphone camera. This intelligent glare-reduction is important for various imaging applications, including autonomous driving, machine vision, and security cameras. The rapid nonlinear processing of incoherent broadband light might also find applications in optical computing, where nonlinear activation functions for ambient light conditions are highly sought.
Hematopoietic stem cells with granulo-monocytic differentiation state overcome venetoclax sensitivity in patients with myelodysplastic syndromes
Authors: Rodriguez-Sevilla Juan Jose , Ganan-Gomez Irene , Ma Feiyang , Chien Kelly , Del Rey Monica , Loghavi Sanam , Montalban-Bravo Guillermo , Adema Vera , Wildeman Bethany , Kanagal-Shamanna Rashmi , Bazinet Alexandre , Chifotides Helen T. , Thongon Natthakan , Calvo Xavier , Hernández-Rivas Jesús María , Díez-Campelo Maria , Garcia-Manero Guillermo , Colla Simona 
Published: March 2024

AbstractThe molecular mechanisms of venetoclax-based therapy failure in patients with acute myeloid leukemia were recently clarified, but the mechanisms by which patients with myelodysplastic syndromes (MDS) acquire secondary resistance to venetoclax after an initial response remain to be elucidated. Here, we show an expansion of MDS hematopoietic stem cells (HSCs) with a granulo-monocytic-biased transcriptional differentiation state in MDS patients who initially responded to venetoclax but eventually relapsed. While MDS HSCs in an undifferentiated cellular state are sensitive to venetoclax treatment, differentiation towards a granulo-monocytic-biased transcriptional state, through the acquisition or expansion of clones with STAG2 or RUNX1 mutations, affects HSCs’ survival dependence from BCL2-mediated anti-apoptotic pathways to TNFα-induced pro-survival NF-κB signaling and drives resistance to venetoclax-mediated cytotoxicity. Our findings reveal how hematopoietic stem and progenitor cell (HSPC) can eventually overcome therapy-induced depletion and underscore the importance of using close molecular monitoring to prevent HSPC hierarchical change in MDS patients enrolled in clinical trials of venetoclax.
HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species
Authors: Chen Sheng , Puri Anuradhika , Bell Braxton , Fritsche Joseph , Palacios Hector H. , Balch Maurie , Sprunger Macy L. , Howard Matthew K. , Ryan Jeremy J. , Haines Jessica N. , Patti Gary J. , Davis Albert A. , Jackrel Meredith E. 
Published: March 2024

AbstractParkinson’s disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease, and inactivating mutations to mitochondrial HTRA2 are implicated in PD. Here, we report that HTRA1 inhibits aggregation of α-syn as well as FUS and TDP-43, which are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The protease domain of HTRA1 is necessary and sufficient for inhibiting aggregation, yet this activity is proteolytically-independent. Further, HTRA1 disaggregates preformed α-syn fibrils, rendering them incapable of seeding aggregation of endogenous α-syn, while reducing HTRA1 expression promotes α-syn seeding. HTRA1 remodels α-syn fibrils by targeting the NAC domain, the key domain catalyzing α-syn amyloidogenesis. Finally, HTRA1 detoxifies α-syn fibrils and prevents formation of hyperphosphorylated α-syn accumulations in primary neurons. Our findings suggest that HTRA1 may be a therapeutic target for a range of neurodegenerative disorders.
Projecting the long-term effects of the COVID-19 pandemic on U.S. population structure
Authors: Tilstra Andrea M. , Polizzi Antonino , Wagner Sander , Akimova Evelina T. 
Published: March 2024

AbstractThe immediate, direct effects of the COVID-19 pandemic on the United States population are substantial. Millions of people were affected by the pandemic: many died, others did not give birth, and still others could not migrate. Research that has examined these individual phenomena is important, but fragmented. The disruption of mortality, fertility, and migration jointly affected U.S. population counts and, consequently, future population structure. We use data from the United Nations World Population Prospects and the cohort component projection method to isolate the effect of the pandemic on U.S. population estimates until 2060. If the pandemic had not occurred, we project that the population of the U.S. would have 2.1 million (0.63%) more people in 2025, and 1.7 million (0.44%) more people in 2060. Pandemic-induced migration changes are projected to have a larger long-term effect on future population size than mortality, despite comparable short-term effects.