bluuebunny/crossref_metadata_2025_split huggingface dataset:
St. Lawrence of Dublin
Authors: Watkin Edward Ingram 
Published: August 2007

After wellnigh eight centuries of cruelty and hate, peace seems now at last to be dawning upon Ireland. In a poem of servile flattery addressed in 1545 to Henry VIII by the antiquary Leland, are three Latin verses to celebrate an imagined final settlement of the Irish question. “Repentance has subdued the savage Irish everywhere routed, and has taught them to bear the sweet yoke of British law.” After the experience of some four further centuries of persistent attempt to force on the Irish the “yoke” —to their taste not sweet but bitter—of an alien people, we have at long last learnt that the only true and final peace between England and Ireland must be based on liberty and justice. Whether the present treaty be wholly in accordance with these is a political question I do not wish to raise. Only this is surely evident that it does offer such measure of both as will enable Ireland to enter with full self-respect a new and a better union with England, a union not of force and terror, but of free co-operation. That the dawn is overcast with the storm clouds of bitter opposition from irreconcilables should not make us despondent. For the storm clouds will pass over, and the dawn will brighten into daylight.While we are thus watching the dawn with a hope not to be killed by passing anxieties, it seems opportune to remember one who at the very hour of sunset, when the shadows of the coming night were beginning to darken over his country, worked for that dawn whose rise we now witness.
Dan Bartholomew and the Fair Châtelaine
Authors: Eden Helen Parry 
Published: August 2007

Seven hundred years ago, in a castle not twenty miles from Canterbury, there lived a very vain and beautiful lady. She was the wife of the lord of the manor and was known from Oxford to Jerusalem— wherever there were knights to joust for her and minstrels to sing of her—as the Fair Châtelaine. And there was also, tucked away in a little cell under the castle leads, a very holy old priest called Dan Bartholomew, who said Mass for the inmates of the castle and did his best to look after their souls.This was no light task. For though the lord of the castle was a pious enough man when he was at home (which was not often), and the poor peasants round about found time between dawn and dusk to say a few prayers and light a few candles in the forlorn little chapel by the gate-house, the lady kept as far as she could from prayer and altogether from penance. Yet certainly few people needed penance more than that worldly dame. Never a year went by but she spent a knight’s ransom in clothes ; and the older she got and the more her beauty waned, the more new-fangled and costly became her attire.Of course in her husband’s absence it was Dan Bartholomew’s business to check her ; but she was like the crab which when asked why it walked sideways said, “So I learnt from my parents,” and gave him nothing but saucy answers in return for his serious admonitions. When her husband came back from the Crusade it was even worse.
Four Great Russians
Authors: Ayscough John 
Published: August 2007

When Peter the Great built St. Petersburg he said he was opening a window into Europe. Gogol, Turgenief, Tolstoy, and Dostoievsky opened the greatest windows that we have even yet into Russia. The Russia that they described is buried, though perhaps it is not really dead. It may yet stretch its enormous bulk and cast away its foul and bloody grave-clothes.At all events, the Russia of those four masters has disappeared behind the Red Dark. Their work is not the less interesting, and would not be, even if the disappearance should be final. It would remain a portentous monument four-square ; Gogol’s side the most uncouth, but not the least striking; Turgenief’s the most ornamental and most adorned, but not the most definite—indeed, the least national and the least powerful; Tolstoy’s the most eulogized, perhaps the most renowned, but not the greatest or the strongest; Dostoievsky’s the most passionately truthful, sincere, and pathetic, if also the most terrible. Of these four architects of the great monument, Turgenief was the least Russian : he had lived in the light of common day outside, and he wrote from memory ; into his memories shone gleams of a western sun. His pen was half-civilized, and that gain was a loss to him. One meets in his books characters that one might meet in a French novel—though it would be one of the finest and best of the French novels. He had ideas of beauty less Russian than western, and his absence tempered his pictures ; he desired that they should please, and a certain haze of gentleness softens their definition. They are incomparably less massive, less prepotent, than Gogol’s or Dostoievsky’s, and are weakened by their graciousness. There was nothing gracious about Gogol’s pictures ; he painted brutally and did not shrink from their brutality, or dream of making it please. The truth he saw was vastly ugly, and he was only concerned to show it vast and true. He did not write of civilized persons and did not himself pose as a civilized writer. He stripped himself and his characters to the shirt, and gave the latter no pose and no quarter.
Music for Midnight Mass
Authors: Dayrell Vivienne 
Published: August 2007

Swing thy slow circles, Thurible, before His Face,Nor let there one grain fall Of incense . . . for the thurible is Space,Unstarréd Space : and this revolving ball One grain of incense in the dust of all,That in the solemn silence no winds stir.. . . Planets and constellations , . . these are votive myrrh And frankincense, to give sweet-scented praise And prayer, before the Stall Where lies the Lord of All.. . . Swing thy slow circles, Thurible, before His Face.Swing thy slow circles, Thurible, before His Feet ...O Planets, nought save earth,Dust shall you burn before His judgment throneAs now you burn to celebrate His birthWhen all the Sons of God exult and sing for mirth.. . . Pale streams of stars, you smoke in sacrifice Perpetually slow-rising up to Paradise Still as unwavering flame and faintly sweet,To praise the Eternal One,Incarnate Word, the Son. -. . . Swing thy slow circles, Thurible, before His Feet.Swing thy slow circles, Thurible, for Him, thy Lord,Within Whose Hand, heaped lightThe Cosmos lies : and through Whose Fingers pouredRun like fine sand the planets . . . they that writeHigh in black Space the message of His mightWho sleeps, half-hearing through His dreams, the SongRise as a tide, triumphantly and strong—“ Stars as tall altar-tapers light With steady flame the deeps of Night,But low in the heavens a greater shines.Kings have found the keyOf this MysteryIn the last of all the Signs.”
Waughs and Rumours of Waughs
Authors: Jarrett Bede 
Published: August 2007

A wholly new influence over books written on school-life began with Compton Mackenzie and Sinister Street. Previously to that there had indeed been school stories, an endless procession of them, including such masterpieces as Tom Brown's Schooldays and others that like Eric sought to appeal frankly to that innate sentimentalism that lies uncomfortably across the conscience of every English boy. These, however, had culminated in The Hill, The Harrovians, and The Bending of the Twig, which are the three finest probably of that older school of Romanticism, throwing its touching veil of fights, friendship, and laughter over the hardened formalities and dreary littlenesses of normal school-life. These represent, then, the final effort of a style of writing which had become obsolete when dealing with “Olympians,” but was still employed in the happy efforts of grown men to recapture the spirit of boyhood, its inner sanctities and outer brutalities, its sorrows, its heartiness, its monotony, its intrigues as baffling, and to master and pupil as entrancing as the political games that interest and exhaust the diplomats of a larger world.Then came the first volume of Sinister Street. This must be too well known to all readers of Blackfriars to require much treatment here : but its importance is hardly to be calculated. It opened the eyes of boys to the fascinating study of self-analysis : for it differed in two respects from previous ventures, in that first, it was written by one who had hardly left school, and secondly, it was a very detailed description of the changing attitude of a boy’s mind, its unfolding to good and evil, and thus it interested the reader, as often as not a boy-reader, in watching the changing attitude of his own mind.
Richard Crashaw
Authors: Makepeace John Foster 
Published: August 2007

In the year that Charles the First came to the throne, Richard Crashaw was a lad of thirteen at the Charterhouse School. He had lost his mother in his infancy, and his father—the Rev. William Crashaw, a learned theologian, eloquent preacher, indifferent poet and bitter anti-Catholic— had recently died, leaving him with slender resources, but endowed with uncommon abilities and a rare gift for making friends.He went to Cambridge in 1631 ; was admitted to Pembroke College ; gained a pensionership, having, as he afterwards wrote to a friend, spent all his patrimony in buying books ; and graduated in 1634 when he was twenty-one. In the same year he published a book of Scripture Epigrams in Latin, memorable for the one immortal line, “Nympha pudica Deum vidit, et erubuit,” upon which the skill of many translators, including William Hayley, has been exercised.To draw a true portrait of Richard Crashaw he must be presented in this University setting. For he was, pre-eminently, in modern phrase, a “‘Varsity man.” The advantage of life at the older universities, it has often been said, has always been found to lie as much in the friendships that common studies foster as in the studies themselves. Crashaw enjoyed both to the full. Clearly, he was a student, and lived austere, laborious days, for he became proficient in the classics, as well as in Hebrew, Italian, and Spanish, besides in acquiring some skill in music and art. And the finest minds at the University were his friends. Of these latter we learn something from the numerous elegies he composed, according to the custom of the day.
Nationality
Authors: Devas Dominic 
Published: August 2007

Nationality as an isolating force is new in the world, an artificial, after-Christian growth, dating from the break-up of Christendom at the so-called Reformation in the sixteenth century. Mutual hostility between races—as opposed to conflicts between a prince and his followers of one State, and a prince of another State and his followers—is not new, but a relapse into fore-Christian barbarism, when the cult of local deities, little knowledge of each other, and total inexperience of political union, led men to regard differences of race as natural and insurmountable barriers, when to be a stranger, a man of another race and creed, was—as it has since become—to be necessarily an enemy, so that the same word—hostis—once did for both. This idea of war between races as natural— , says Plato in Book I of his Laws—was gradually checked politically by the rise of the Roman Empire and the permanence of the Imperial idea, and, on the religious side, by Christianity with its doctrine of the unity of God and of the unity of man made to His Image and equal before Him. Thus with the of Plato we may contrast St. Paul’s ‘.There is neither Jew nor Greek : there is neither bond nor free. . . . For you are all one in Christ Jesus’ (Gal. iii. 28).”Is this a wholly wild and quite untrue presentation of history? Such measure of truth as it may be found to contain will perhaps emerge as we proceed with our enquiry.
The Church in France and the Ruhr
Authors: Gwynn Denis 
Published: August 2007

In her decision to seize the Ruhrland, France has committed herself to a course which leaves her practically no possibility of turning back. The gravity of her decision is already appreciated throughout the country, and the Press is busy exhorting all classes of the population to pay no heed to criticism of French policy and to face the trials which she has chosen to encounter with unflinching resolution and with a determination to rely solely upon Frances own resources. This is not the place to discuss the merits or otherwise of the policy which France has adopted. But in order to make clear the extremely serious dangers which it involves for the position of the Church in France if failure in the Ruhr should lead to a violent political reaction towards the Left, it is necessary to indicate briefly the principal factors in the situation.In the first place it must be stated quite frankly that no one who sympathises with France in the difficulties with which she has been surrounded since the war could well see how the adventure into the Ruhr was to be avoided. The occupation of the Ruhr was Frances last card against Germany, and as all else had failed, France simply had to play it or acquiesce meekly in Germanys triumphant default. It is not fair to say that France is prepared to drive Europe into war rather than undertake to pay for her own reconstruction out of taxes.
Liturgical Hymns
Authors: Britten James 
Published: August 2007

Among the few incidents of my ill-spent life which . I hope may be accounted to me for righteousness is the suppression of a hymn-book. At first sight this might appear to somewho do not know what literary crimes are committed under that innocent-seeming namea matter for remorse rather than for pride, for regret rather than for congratulation. But I will venture in justification to apply to myself the response of the prudent Rector of a seminary who, when told by a scrupulous student that he had discovered a new mortal sin, replied : Then, my son, keep it to yourself and never mention it; there are far too many known already. Yet when I add that the hymn-book was to have appeared under the protection of a Cardinal, my daring will seem to demand yet further excuse; so it will be simplest to say what actually happened.The late Cardinal Vaughan, as is well known, had a burning desire for the conversion of England and, with that object in view, to bring the Church into contact with the people. It was this that impelled him to establish the original Catholic Truth Society for the publication or for dissemination of cheap popular Catholic books; and when, owing to various circumstances, that Society ceased to function, he gladly placed himself at the head of the new organisation established for the same purpose, retaining that position until his death in 1903. Apart from the C.T.S. the Cardinal issued a series of People's Manuals, prepared by himself, which had a very large sale.
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Authors: Caslini Corrado , Yang Zhaohai , El-Osta Mohamad , Milne Thomas A. , Slany Robert K. , Hess Jay L. 
Published: August 2007

Abstract
Rearrangements of the mixed lineage leukemia gene MLL are associated with aggressive lymphoid and myeloid leukemias. The resulting MLL fusion proteins enforce high-level expression of HOX genes and the HOX cofactor MEIS1, which is pivotal for leukemogenesis. Both wild-type MLL and MLL fusion proteins interact with the tumor suppressor menin and with the Hoxa9 locus in vivo. Here, we show that MLL sequences between amino acids 5 and 44 are required for interaction with menin and for the transformation of hematopoietic progenitors. Blocking the MLL-menin interaction by the expression of a dominant negative inhibitor composed of amino terminal MLL sequences down-regulates Meis1 expression and inhibits cell proliferation, suggesting that targeting this interaction may be an effective therapeutic strategy for leukemias with MLL rearrangements. [Cancer Res 2007;67(15):7275–83]
p53 Activation in Response to Mitotic Spindle Damage Requires Signaling via BubR1-Mediated Phosphorylation
Authors: Ha Geun-Hyoung , Baek Kwan-Hyuck , Kim Hyun-Soo , Jeong Sook-Jung , Kim Chang-Min , McKeon Frank , Lee Chang-Woo 
Published: August 2007

Abstract
The mitotic spindle checkpoint plays a crucial role in regulating accurate chromosome segregation and preventing the adaptation of multiploid progeny cells. Recent reports have indicated that the induction of p53 by mitotic checkpoint activation is essential for protecting cells from abnormal chromosome ploidization caused by mitotic failure. However, although studies have shown that p53 deficiencies arrest mitosis, compromise apoptosis, and may cause profound aneuploidy, the molecular mechanisms leading to p53 induction following mitotic checkpoint activation remain unknown. Here, we show that the BubR1 mitotic checkpoint kinase interacts with p53 both in vitro and in vivo, with higher levels of interaction in mitotic cells. This interaction contributes to p53 phosphorylation. Silencing of BubR1 expression reduces the phosphorylation and stability of p53, whereas exogenous introduction of BubR1 proteins into BubR1-depleted cells recovers p53 stability. In addition, inhibition of BubR1 expression in the presence of a microtubule inhibitor accelerates chromosomal instability and polyploidy in p53-null cells. These results collectively suggest that p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. [Cancer Res 2007;67(15):7155–64]
Targeting Matrix Metalloproteinases and Endothelial Cells with a Fusion Peptide against Tumor
Authors: Zou Yufei , Chen Yahui , Jiang Yongqiang , Gao Jin , Gu Jun 
Published: August 2007

Abstract
Development of novel therapy for patients with tumor is still a challenge at the present time. We designed a fusion peptide (RK5) with two targets as a novel agent against tumor. The fusion peptide RK5 containing the kringle 5 fragment of human plasminogen and a decapeptide (CTTHWGFTLC) was constructed and expressed in yeast. Matrix metalloproteinase (MMP) activity, proliferation, and migration of endothelial cells were examined in vitro, respectively. Angiogenesis, tumor growth, metastasis, and survival time were evaluated in in vivo models. Administration of RK5 was delivered by both protein and gene approach. The results showed that RK5 inhibited the activity of MMP-9 and exhibited more inhibitory effects on proliferation and migration of endothelial cells than that of kringle 5 fragment and decapeptide individually. RK5 also inhibited angiogenesis, tumor growth, and metastasis and increased survival time of mice bearing tumor. In addition, the effectiveness of RK5 could be achieved by both protein and gene delivery. In conclusion, RK5 has potential to inhibit tumor growth and metastasis and to prolong survival time of animals bearing tumor. Therefore, fusion peptide RK5 with two targets provides a new design for the development of antitumor drugs and has potential for clinical application. [Cancer Res 2007;67(15):7295–300]
Tripeptidyl-peptidase II Controls DNA Damage Responses and In vivo γ-Irradiation Resistance of Tumors
Authors: Hong Xu , Lei Lu , Künert Brita , Naredla Rajender , Applequist Steven E. , Grandien Alf , Glas Rickard 
Published: August 2007

Abstract
Cellular responses to γ-irradiation exposure are controlled by phosphatidylinositol 3-kinase–related kinases (PIKK) in the nucleus, and in addition, cytosolic PIKKs may have a role in such responses. Here, we show that the expression of tripeptidyl-peptidase II (TPPII), a high molecular weight cytosolic peptidase, required PIKK signaling and that TPPII was rapidly translocated into the nucleus of γ-irradiated cells. These events were dependent on mammalian target of rapamycin, a cytosolic/mitochondrial PIKK that is activated by γ-irradiation. Lymphoma cells with inhibited expression of TPPII failed to efficiently stabilize p53 and had reduced ability to arrest proliferation in response to γ-irradiation. We observed that TPPII contains a BRCA COOH-terminal–like motif, contained within sequences of several proteins involved in DNA damage signaling pathways, and this motif was important for nuclear translocation of TPPII and stabilization of p53. Novel tripeptide-based inhibitors of TPPII caused complete in vivo tumor regression in mice in response to relatively low doses of γ-irradiation (3–4 Gy/wk). This was observed with established mouse and human tumors of diverse tissue backgrounds, with no tumor regrowth after cancellation of treatment. These TPPII inhibitors had minor effects on tumor growth as single agent and had low cellular toxicity. Our data indicated that TPPII connects signaling by cytosolic/mitochondrial and nuclear PIKK-dependent pathways and that TPPII can be targeted for inhibition of tumor therapy resistance. [Cancer Res 2007;67(15):7165–74]
Decreased Tumor Surveillance after Adoptive T-Cell Therapy
Authors: Matter Matthias , Pavelic Viktor , Pinschewer Daniel D. , Mumprecht Sabine , Eschli Bruno , Giroglou Tsanan , von Laer Dorothee , Ochsenbein Adrian F. 
Published: August 2007

AbstractThe effect of cancer immunotherapy on the endogenous immune response against tumors is largely unknown. Therefore, we studied immune responses against murine tumors expressing the glycoprotein (GP) and/or nucleoprotein of lymphocytic choriomeningitis virus (LCMV) with or without adoptive T-cell therapy. In nontreated animals, CTLs specific for different epitopes as well as LCMV-GP–specific antibodies contributed to tumor surveillance. Adoptive immunotherapy with monoclonal CTLs specific for LCMV-gp33 impaired the endogenous tumor-specific antibody and CTL response by targeting antigen cross-presenting cells. As a consequence and in contrast to expectations, immunotherapy enhanced tumor growth. Thus, for certain immunogenic tumors, a reduction of tumor-specific B- and T-cell responses and enhanced tumor growth may be an unwanted consequence of adoptive immunotherapy. [Cancer Res 2007;67(15):7467–76]
An Improved Bioluminescence Resonance Energy Transfer Strategy for Imaging Intracellular Events in Single Cells and Living Subjects
Authors: De Abhijit , Loening Andreas Markus , Gambhir Sanjiv Sam 
Published: August 2007

Abstract
Bioluminescence resonance energy transfer (BRET) is currently used for monitoring various intracellular events, including protein-protein interactions, in normal and aberrant signal transduction pathways. However, the BRET vectors currently used lack adequate sensitivity for imaging events of interest from both single living cells and small living subjects. Taking advantage of the critical relationship of BRET efficiency and donor quantum efficiency, we report generation of a novel BRET vector by fusing a GFP2 acceptor protein with a novel mutant Renilla luciferase donor selected for higher quantum yield. This new BRET vector shows an overall 5.5-fold improvement in the BRET ratio, thereby greatly enhancing the dynamic range of the BRET signal. This new BRET strategy provides a unique platform to assay protein functions from both single live cells and cells located deep within small living subjects. The imaging utility of the new BRET vector is shown by constructing a sensor using two mammalian target of rapamycin pathway proteins (FKBP12 and FRB) that dimerize only in the presence of rapamycin. This new BRET vector should facilitate high-throughput sensitive BRET assays, including studies in single live cells and small living subjects. Applications will include anticancer therapy screening in cell culture and in small living animals. [Cancer Res 2007;67(15):7175–83]