bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding students' feedback use in medical progress testing: A qualitative interview study
Authors: van Wijk Elise V. , van Blankenstein Floris M. , Janse Roemer J. , Dubois Eline A. , Langers Alexandra M. J. 
Published: March 2024

AbstractBackgroundActive engagement with feedback is crucial for feedback to be effective and improve students' learning and achievement. Medical students are provided feedback on their development in the progress test (PT), which has been implemented in various medical curricula, although its format, integration and feedback differ across institutions. Existing research on engagement with feedback in the context of PT is not sufficient to make a definitive judgement on what works and which barriers exist. Therefore, we conducted an interview study to explore students' feedback use in medical progress testing.MethodsAll Dutch medical students participate in a national, curriculum‐independent PT four times a year. This mandatory test, composed of multiple‐choice questions, provides students with written feedback on their scores. Furthermore, an answer key is available to review their answers. Semi‐structured interviews were conducted with 21 preclinical and clinical medical students who participated in the PT. Template analysis was performed on the qualitative data using a priori themes based on previous research on feedback use.ResultsTemplate analysis revealed that students faced challenges in crucial internal psychological processes that impact feedback use, including ‘awareness’, ‘cognizance’, ‘agency’ and ‘volition’. Factors such as stakes, available time, feedback timing and feedback presentation contributed to these difficulties, ultimately hindering feedback use. Notably, feedback engagement was higher during clinical rotations, and students were interested in the feedback when seeking insights into their performance level and career perspectives.ConclusionOur study enhanced the understanding of students' feedback utilisation in medical progress testing by identifying key processes and factors that impact feedback use. By recognising and addressing barriers in feedback use, we can improve both student and teacher feedback literacy, thereby transforming the PT into a more valuable learning tool.
Heart rate score in remote monitoring: An additional tool for predicting outcomes in heart failure with reduced ejection fraction
Authors: Barradas Maria Inês , Coutinho dos Santos Inês , Duarte Fabiana , Viveiros Monteiro André , Tavares Anabela , Martins Dinis 
Published: March 2024

AbstractBackgroundHeart rate score (HRS) ≥ 70% has been associated with arrhythmic events and mortality but these studies were not specific for heart failure (HF) patients. We hypothesized that HRS ≥ 70% obtained from remote monitoring (RM) is associated with HF hospitalizations and arrhythmic events in HF with reduced ejection fraction (HFrEF).MethodsHRS was calculated from RM in patients with HFrEF and ICD or CRT‐D. Two groups were defined: HRS ≥ 70% (G1, n = 55) and HRS < 70% (G2, n = 48)ResultsA total of 103 patients were included (64.4 ± 13.04 years, 69.9% male, mean left ventricular ejection fraction (LVEF) 33.62 ± 11.97% and FUP 61.7 ± 38.87 months). The device was CRT‐D in 59.2% and ICD in 40.8% and the majority (90.3%) had the device implanted in primary prevention. G1 patients were more frequently male (p = .017) and had more coronary disease (p = .035). HRS ≥70% was an independent predictor for unplanned HF hospitalizations (OR: 1.905 (95% CI: 1.328–3.649), p < .001)). The indication for device implantation (primary vs. secondary prevention), type of device, NYHA class, age, gender and LVEF were not independent predictors of the outcome. VF (4.9 ± 20.0 G1 vs. 1.1 ± 5.47 G2, p = .046) and VT episodes were more prevalent in G1 (3.1 ± 8.93 G1 vs. 0.3 ± 1.59 G2, p = .026), as well as appropriate device shocks (4.3 ± 12.06 G1 vs. 0.3 ± 1.49 G2, p = .023). There was no difference in inappropriate shocks or mortality outcomes between groups.ConclusionHRS ≥70% obtained from RM was an independent predictor of HF hospitalizations and was associated with arrhythmic events with VT and VF episodes and appropriate device shocks in HFrEF patients.
Subcutaneous air entrapment after subcutaneous implantable cardioverter defibrillator implantation evaluated by computed tomography
Authors: Taguchi Yuka , Ishikawa Toshiyuki , Matsumoto Katsumi , Narikawa Masatoshi , Okazaki Yoshinori , Miyagawa Shuichi , Horigome Akira , Hosoda Junya 
Published: March 2024

AbstractBackgroundInappropriate shock (IAS) caused by subcutaneous air entrapment (AE) in an early period after subcutaneous implantable cardioverter defibrillator (S‐ICD) implantation has been reported, however, no detailed data on air volume are available. We evaluated the subcutaneous air volume after implantation and its absorption rate one week after implantation.MethodsPatients who underwent S‐ICD implantation in our hospital received chest CT scans immediately after implantation and followed up 1 week later. The total subcutaneous air volume, air around the generator, the distal electrode, and the proximal electrode within 3 cm were calculated using a three‐dimensional workstation. Fat areas at the level of the lower edge of the generator were also analyzed.ResultFifteen patients received CT immediately after implantation. The mean age was 45.6 ± 17.9 (66.7% of men), and the mean body mass index was 24.3 ± 3.3. The three‐incision technique was applied in seven patients and two‐incision technique was in the latter eight patients. The mean total subcutaneous air volume was 18.54 ± 7.50 mL. Air volume around the generator, the distal electrode, and the proximal electrode were 11.05 ± 5.12, 0.72 ± 0.72, and 0.88 ± 0.87 mL, respectively. Twelve patients received a follow‐up CT 1 week later. The mean total subcutaneous air was 0.25 ± 0.45 mL, showing a 98.7% absorption rate.ConclusionAlthough subcutaneous air was observed in all patients after S‐ICD implantation, most of the air was absorbed within 1 week, suggesting a low occurrence of AE‐related IAS after a week postoperation.
Reduced reactivity to fear conditioning and pain tests in persons involved in violent video gaming is influenced by adverse childhood experiences
Authors: Penzkofer Maximilian , Daub Julia , Becker Susanne , Flor Herta 
Published: March 2024

AbstractVideo gaming, including violent video gaming, has become very common and lockdown measures of the COVID‐19 pandemic even increased the prevalence rates. In this study, we examined if violent video gaming is associated with more adverse childhood experiences (ACE) and if it impairs pain processing and fear conditioning. We tested three groups of participants (violent video gamers, nonviolent video gamers, and non‐gamers) and examined fear conditioning as well as pain perception during functional magnetic resonance imaging (fMRI). Violent video gamers displayed significantly higher pain thresholds as well as pain tolerance for electric stimulation, pressure pain stimulation, and cold pressor pain measurements than nonviolent video gamers and non‐gamers. This relationship was moderated by adverse childhood experiences, especially physical neglect. Brain images acquired during the fear conditioning fMRI task showed that violent video gamers display significantly less differential brain activation to stimuli signaling pain versus no pain in the anterior cingulate cortex, the juxtapositional lobule cortex, and the paracingulate gyrus compared to non‐gamers. There was also a significant negative correlation between adverse childhood experiences and activation in the precuneus and the intracalcarine cortex for signals of pain versus safety. The results of this study imply that violent video gaming is related to reduced processing of pain and signals of pain in a fear learning task, dependent of adverse childhood experiences. These mechanisms need to be examined in more detail and these data could be helpful in preventing the onset and adverse consequences of violent video gaming.
Internalized political repression: Legacies of authoritarianism in the U.S.‐based Syrian diaspora during the Arab Spring
Authors: Almasalkhi Nadia 
Published: March 2024

AbstractAuthoritarian regimes are known to repress the political activity of their diasporas transnationally by threatening harsh sanctions. But is this their only mode of transnational repression? This article builds on scholarship on social control to explore whether migrants bring internalized forms of political repression from their authoritarian home country to their democratic country of settlement—and if so, how it shapes their transnational political activity. In‐depth life‐history interviews with 29 U.S.‐citizen and permanent‐resident Syrian immigrants living in Los Angeles, California and Louisville, Kentucky reveal that for many U.S.‐based Syrians, demobilizing emotions, interpretive frames, and habits learned in Syria depressed their transnational political activity during the Arab Spring. Four internalized mechanisms of transnational political repression are conceptualized: learned helplessness, chronic fear of politics and the State, political trauma, and disciplined aversion to political expression. Leveraging comparisons between activists, demobilized activists, and non‐activists, this article demonstrates the connections between specific political socialization experiences, internalized political repression, and transnational political (in)activity. This article contributes to the growing literature on constraints and barriers to transnational mobilization, and to the debate over the role of pre‐migration political experience on immigrants' political participation.
Genome sequence and annotation of
Arthrobacter globiformis
phage Ruchi (AS1) isolated from soil in Lumpkin County, Georgia
Authors: Tatum Brooke , Murray Payton , Bicknell Claire , Webb Shane A. , Kanak Alison 
Published: March 2024

ABSTRACT

Ruchi
,
a temperate, AS1 subcluster bacteriophage isolated in Lumpkin County, Georgia using host
Arthrobacter globiformis
, possesses a genome of 38,571 bp and 67.7% GC. Annotation of this virus revealed 64 predicted reading frames, no predicted tRNA genes, and a close evolutionary relationship to AS1 phage Basilisk.
Ṭāhir Īshān’s Unknown Autograph Manuscripts
Authors: Shanazarova Aziza 
Published: March 2024

Abstract
The current article examines autograph manuscripts of three little-known Sufi doctrinal works of the eighteenth-century Central Asian Sufi, Ṭāhir Īshān, a native of Khwarazm. Ṭāhir Īshān is better known as the author of the eighteenth-century Naqshbandī hagiographical compendium Tadhkira-yi Ṭāhir Īshān, which was completed in 1160/1747. The works in question, entitled Ḥujjat al-sālikīn va rāḥat al-ṭālibīn, Rumūz al-kalām, and Risāla-yi sayr ilā Llāh, survived in their autograph copies in a single manuscript codex preserved at the Beruni Institute of Oriental Studies in Tashkent (Uzbekistan), under the inventory number of MS 5121. Given that the Rumūz al-kalām and Risāla-yi sayr ilā Llāh only survived in their autograph copies, MS 5121 serves as a crucial gateway to these doctrinal texts of Ṭāhir Īshān.
Archives of Discrimination
Authors: Bustanov Alfrid , Shikhaliev Shamil 
Published: March 2024

Abstract
The present article traces the history of multiple private and state archives in Daghestan. Such collections bear imprints of competition between particular individuals and factions. As we shall see, various parties exploited the cultural resources available to them in order to project their subjectivities onto the textual and material evidence. Shifts in cultural values and fashions, together with transformations in language use and an ongoing struggle for personal and communal representation, contributed jointly to the formation of multi-layered discourses on the past. If we are to make sense of our sources, therefore, we must engage with a multitude of competing discourses that have privileged one type of historical view over others, thereby shaping the contours of the body of available material, and rendering information lacunae not just unavoidable, but themselves reflective of past events. Colonialism and coloniality are not alone in having helped configure the power structures that we find manifested in state archives. In fact, much of the competition, marginalization, and careful selection took place even before the transfer of documents to imperial institutions.
Anti-proliferative Effects of Pinocembrin Isolated From Anomianthus dulcis on Hepatocellular Carcinoma Cells
Authors: Saengboonmee Charupong , Thithuan Kanyarat , Mahalapbutr Panupong , Taebprakhon Cheerapinya , Aman Aamir , Rungrotmongkol Thanyada , Kamkaew Anyanee , Schevenels Florian Thierry , Chompupong Tanakiat , Wongkham Sopit , Lekphrom Ratsami 
Published: March 2024

Background: Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Anomianthus dulcis (Dunal) J.Sinclair (syn. Uvaria dulcis) has been used in Thai traditional medicine in various therapeutic indications. Phytochemical constituents of A. dulcis have been isolated and identified. However, their effects on liver cancer and the associated mechanisms have not been elucidated. Methods: Dry flowers of A. dulcis were extracted using organic solvents, and chromatographic methods were used to purify the secondary metabolites. The chemical structures of the pure compounds were elucidated by analysis of spectroscopic data. Cytotoxicity against HCC cells was examined using SRB assay, and the effects on cell proliferation were determined using flow cytometry. The mechanisms underlying HCC inhibition were examined by molecular docking and verified by Western blot analysis. Results: Among 3 purified flavonoids, pinocembrin, pinostrobin, and chrysin, and 1 indole alkaloid (3-farnesylindole), only pinocembrin showed inhibitory effects on the proliferation of 2 HCC cell lines, HepG2 and Li-7, whereas chrysin showed specific toxicity to HepG2. Pinocembrin was then selected for further study. Flow cytometric analyses revealed that pinocembrin arrested the HCC cell cycle at the G1 phase with a minimal effect on cell death induction. Pinocembrin exerted the suppression of STAT3, as shown by the molecular docking on STAT3 with a better binding affinity than stattic, a known STAT3 inhibitor. Pinocembrin also suppressed STAT3 phosphorylation at both Tyr705 and Ser727. Cell cycle regulatory proteins under the modulation of STAT3, namely cyclin D1, cyclin E, CDK4, and CDK6, are substantially suppressed in their expression levels. Conclusion: Pinocembrin extracted from A. dulcis exerted a significant growth inhibition on HCC cells via suppressing STAT3 signaling pathways and its downstream-regulated genes.
Proof of Concept: Development of a Mitral Annuloplasty Ring With Crosshatch Net
Authors: Seadler Benjamin D. , Joyce David L. , Zelten James , Sweeney Kevin , Wisgerhof Taylor , Slettehaugh Zoey , Yuan Y. William , Tefft Brandon J. , Pearson Paul J. 
Published: March 2024

Objective: Here we report our preclinical, proof-of-concept testing to assess the ability of a novel device to correct mitral regurgitation. The Milwaukee Heart device aims to enable any cardiac surgeon to perform high-quality mitral valve repair using a standard annuloplasty ring with a crosshatch of microporous, monofilament suture. Methods: Hemodynamic, echocardiographic, and videographic data were collected at baseline, following induction of mitral regurgitation, and after repair using porcine hearts in an ex vivo biosimulator model. A commercially available cardiac prosthesis assessment platform was then used to assess the hydrodynamic characteristics of the study device. Results: Porcine biosimulator pressure and flow metrics exhibited successful correction of mitral regurgitation following device implantation with similar values to baseline. Hydrodynamic results yielded pressure gradients and an effective orifice area comparable to currently approved prostheses. Conclusions: The study device effectively reduced mitral valve regurgitation and improved hemodynamics in our preclinical model with similar biophysical metrics to currently approved devices. Future in vivo trials are needed to evaluate the efficacy, biocompatibility, and freedom from the most likely adverse events, such as device thrombosis, embolic events, and hemolysis.
Vulnerability of the Agricultural Commodity Markets in Ghana to Global Oil Price Fluctuations: An Empirical Analysis
Authors: Oteng Clement , Iledare Omowumi , Sebu Joshua 
Published: March 2024

Despite the advocacy for climate change goals and encouragement for renewables, crude oil continues to dominate the energy markets. Crude oil price, however, is prone to global price fluctuations. Analyses of these effects on agricultural commodity markets in Ghana is neglected which this study seeks to answer. A nonlinear approach (NARDL) is employed in evaluating the effects of global oil price fluctuation on Ghana’s agricultural commodity market vulnerability, proxied by their producer prices. Different indicators are used since crude price fluctuations might have varying impacts on macroeconomic indicators in both magnitude and signs. Quarterly time series data are sourced from different institutions including data from the Bank of Ghana, FAO, and British Petroleum Statistical Review spanning from 1980: Q1 to 2019: Q4. Empirical results indicate that crude oil price fluctuations have different signs and magnitude for agricultural food commodities prices for both short- and long-runs. The findings of the study bring to bear how the agricultural activities in Ghana respond to variability in global crude oil prices. Policies mitigating changes in prices of animal products ought to be grounded on other issues instead of changes in crude oil prices. Also, programs such as “Planting for Food and Jobs” must be implemented in effectively. JEL Classification: Q02; C32; E31; H23
Adoptive transfer of donor B lymphocytes: a phase 1/2a study for patients after allogeneic stem cell transplantation
Authors: Winkler Julia , Tittlbach Hannes , Schneider Andrea , Vasova Ingrid , Strobel Julian , Herold Susanne , Maas Stefanie , Spriewald Bernd M. , Repp Roland , Kordelas Lambros , Mach Michael , Wolff Daniel , Edinger Matthias , Mackensen Andreas , Winkler Thomas H. 
Published: March 2024

Abstract
Immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is slow and patients carry a high and prolonged risk of opportunistic infections. We hypothesized that the adoptive transfer of donor B cells can foster after HSCT immuno-reconstitution. Here, we report, to our knowledge, the results of a first-in-human phase 1/2a study aimed to evaluate the feasibility and safety of adoptively transferred donor B cells and to test their activity upon recall vaccination. Good manufactoring practice (GMP) B-cell products were generated from donor apheresis products using 2-step magnetic cell separation. Fifteen patients who had undergone allo-HSCT were enrolled and treated after taper of immunosuppression (median, day +148; range, 130-160). Patients received 4 different doses of B cells (0.5 × 106 to 4.0 × 106 B cells per kg body weight). To test the activity of infused donor memory B cells in vivo, patients were vaccinated with a pentavalent vaccine 7 days after B-cell transfer. We observed the mobilization of plasmablasts and an increase in serum titers against vaccine antigens, with a stronger response in patients receiving higher B-cell numbers. Analysis of immunoglobulin VH-sequences by next-generation sequencing revealed that plasmablasts responding to vaccination originated from memory B-cell clones from the donor. Donor B-cell transfer was safe, as no Epstein-Barr virus (EBV) reactivation was observed, and only low-grade graft-versus-host disease (GVHD) occurred in 4 out of 15 patients. This pilot trial may pave the way for further studies exploring the adoptive transfer of memory B cells to reduce the frequency of infections after allo-HSCT. This trial was registered at ClinicalTrial.gov as #NCT02007811.
Towards Sustainable Grinding of Difficult-to-Cut Alloys—A Holistic Review and Trends
Authors: Qian Ning , Chen Jiajia , Khan Aqib Mashood , Zhao Biao , Chen Yurong , Ding Wenfeng , Fu Yucan , Xu Jiuhua 
Published: March 2024

AbstractGrinding, a critical precision machining process for difficult-to-cut alloys, has undergone continual technological advancements to improve machining efficiency. However, the sustainability of this process is gaining heightened attention due to significant challenges associated with the substantial specific grinding energy and the extensive heat generated when working with difficult-to-cut alloys, renowned for their exceptional physical and mechanical properties. In response to these challenges, the widespread application of massive coolant in manufacturing industries to dissipate grinding heat has led to complex post-cleaning and disposal processes. This, in turn, has resulted in issues such as large energy consumption, a considerable carbon footprint, and concerns related to worker health and safety, which have become the main factors that restrict the development of grinding technology. This paper provides a holistic review of sustainability in grinding difficult-to-cut alloys, encompassing current trends and future directions. The examination extends to developing grinding technologies explicitly tailored for these alloys, comprehensively evaluating their sustainability performance. Additionally, the exploration delves into innovative sustainable technologies, such as heat pipe/oscillating heat pipe grinding wheels, minimum quantity lubrication, cryogenic cooling, and others. These groundbreaking technologies aim to reduce dependence on hazardous coolants, minimizing energy and resource consumption and carbon emissions associated with coolant-related or subsequent disposal processes. The essence of these technologies lies in their potential to revolutionize traditional grinding practices, presenting environmentally friendly alternatives. Finally, future development trends and research directions are put forward to pursue the current limitation of sustainable grinding for difficult-to-cut alloys. This paper can guide future research and development efforts toward more environmentally friendly grinding operations by understanding the current state of sustainable grinding and identifying emerging trends.