bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production and carbon emission reduction decisions of remanufacturing firms with low‐carbon credit financing under uncertain demand
Authors: Chen Weida , Chen Zhouhao 
Published: April 2024

AbstractThis paper investigates the optimal production and carbon reduction strategy for a capital‐constrained remanufacturing firm considering demand uncertainty. The remanufacturing firm can accept low‐carbon credit financing. We construct optimization models with no financing and low‐carbon credit financing and analyze the impacts of capital, carbon emission caps, and other factors on the remanufacturer's decision and profit. The results show that (i) the output of remanufactured products and overall profit are higher when using low‐carbon credit financing, regardless of strict carbon emission conditions; (ii) low‐carbon credit can help remanufacturers withstand the impact of carbon price fluctuations; (iii) the demand uncertainty of new and remanufactured products has opposite effects on carbon emission reduction investment; (iv) increasing the carbon cap can enhance the remanufacturing level while a high carbon cap reduce incentives to remanufacture.
Social dance and movement for mental health: A narrative review
Authors: Delattre Brennan , Applewhite Briana , Buckman Joshua E. J. , Harmer Catherine J. , Murphy Susannah E. 
Published: April 2024

AbstractAcross the fields of psychology, neuroscience, and psychiatry, dance—broadly and heterogeneously defined across cultures and movement styles—has been investigated for a range of potential benefits in healthy and clinical populations. There is a growing body of literature investigating the potential for dance, and in particular social forms of dance, to have a positive impact on mental health and well‐being. Given widespread availability through community providers, social dance and movement could be an accessible, non‐invasive, and affordable approach to the prevention and treatment of mood disorders, including depression. However, the existing literature is heterogenous, and there is a lack of methodological cohesiveness and systematization in the field of dance for mental health research. In this narrative review, we propose a novel classification system for social dance mental health research, which encompasses solo dance, partner dance, group dance, dance movement therapy, and cooperative movement. We review the existing literature examining the effects of social dance and movement in the context of low mood and depression and identify future research directions for building a solid evidence base for the application of social dance and movement in the prevention and treatment of mood disorders.
Anisotropy of T2 and T1ρ relaxation time in articular cartilage at 3 T
Authors: Kantola Ville , Karjalainen Jouni , Jaakola Tomi , Leskinen Henri P. P. , Nissi Mikko J. , Casula Victor , Nieminen Miika T. 
Published: April 2024

AbstractPurposeThe anisotropy of R2 and R1ρ relaxation rates in articular cartilage contains information about the collagenous structure of the tissue. Here we determine and study the anisotropic and isotropic components of T2 and T1ρ relaxation parameters in articular cartilage with a clinical 3T MRI device. Furthermore, a visual representation of the topographical variation in anisotropy is given via anisotropy mapping.MethodsEight bovine stifle joints were imaged at 22 orientations with respect to the main magnetic field using T2, continuous‐wave (CW) T1ρ, and adiabatic T1ρ mapping sequences. Relaxation rates were separated into isotropic and anisotropic relaxation components using a previously established relaxation anisotropy model. Pixel‐wise anisotropy values were determined from the relaxation‐time maps using Michelson contrast.ResultsThe relaxation rates obtained from the samples displayed notable variation depending on the sample orientation, magnetization preparation, and cartilage layer. R2 demonstrated significant anisotropy, whereas CW‐R1ρ (300 Hz) and CW‐R1ρ (500 Hz) displayed a low degree of anisotropy. Adiabatic R1ρ was largely isotropic. In the deep cartilage regions, relaxation rates were generally faster and more anisotropic than in the cartilage closer to the tissue surface. The isotropic relaxation rate components were found to have similar values regardless of measurement sequence.ConclusionsThe fitted relaxation model for T2 and T1ρ demonstrated varying amounts anisotropy, depending on magnetization preparation, and studied the articular cartilage layer. Anisotropy mapping of full joints showed varying amounts of anisotropy depending on the quantitative MRI parameter and topographical location, and in the case of T2, showed systematic changes in anisotropy across cartilage depth.
Feasibility of virtual reality and comparison of its effectiveness to biofeedback in children with Duchenne and Becker muscular dystrophies
Authors: Kurt‐Aydin Merve , Savaş‐Kalender Dilan , Tarsuslu Tülay , Yis Uluç 
Published: April 2024

AbstractIntroduction/AimsThe utilization of virtual reality (VR) and biofeedback training, while effective in diverse populations, remains limited in the treatment of Duchenne and Becker muscular dystrophies (D/BMD). This study aimed to determine the feasibility of VR in children with D/BMD and compare the effectiveness of VR and biofeedback in children with D/BMD.MethodsThe study included 25 children with D/BMD. Eight children in the control group participated in a routine follow‐up rehabilitation program, while the remaining children were randomly assigned to the VR (n = 9) and biofeedback (n = 8) groups for a 12‐week intervention. The following evaluations were performed before, during (week 6), and after treatment: Muscle pain and cramps, laboratory studies, muscle strength, timed performance, function (Motor Function Measurement Scale‐32, Vignos, and Brooke Scales), and balance (Pediatric Functional Reach Test and Balance Master System). Motivation for rehabilitation was determined.ResultsThe median ages were 9.00 (VR), 8.75 (biofeedback), and 7.00 (control) years. The study found no significant differences between groups in pretreatment assessments for most measures, except for tandem step width (p < .05). VR and biofeedback interventions significantly improved various aspects (pain intensity, cramp frequency, cramp severity, muscle strength, timed performance, functional level, and balance) in children with D/BMD (p < .05), while the conventional rehabilitation program maintained patients' current status without any changes. The study found VR and biofeedback equally effective, with VR maintaining children's motivation for rehabilitation longer (p < .05).DiscussionThe study showed that both VR and biofeedback appear to be effective for rehabilitation this population, but additional, larger studies are needed.
Study on impact properties of carbon/kevlar fiber hybrid composites
Authors: You Geyi , Gao Yan , Gao Xiaoping , Chen Jiawei , Du Peijian , Gao Mingze , Chen Miao 
Published: April 2024

AbstractIn this article, carbon/kevlar hybrid composites were prepared using Vacuum Assisted Resin Infusion (VARI). The sandwich structure with plain carbon weave fabric as the core layer and plain kevlar weave fabric as the surface layer was selected as reinforcement and the solution of epoxy resin and curing agent was selected as matrix. The low velocity impact experiment and compression after impact (CAI) experiment were carried out on the samples at different hybrid ratio and different temperatures, and the mechanical response on the impact loads were analyzed respectively. The results show that the specimen can limit the delamination defect expansion of the surface kevlar fiber as the carbon fiber used as the core layer, which reduce the delamination defect area and improve the impact resistance of the sample. The toughness of the sample improves the brittle failure mode, that is, the sample still has a certain bearing capacity after the load exceeds the maximum strength, the sandwiched composites presents a positive hybrid effect. With the increase of temperature, the matrix was obviously softened, the macromolecular movement in the system was intensified, the three‐dimensional network macromolecular structure of the matrix and the fiber/matrix interface properties were damaged, and the mechanical properties showed an obvious downward trend. As far as the influences of hybrid ratio and temperature on impact behavior of composite are concerned, it lay a theoretical foundation for the industrial application of carbon/kevlar hybrid composites.Highlights
The sandwiched structure was used to design the composites, which greatly improves the impact properties of the specimens.
The impact properties and compression after impact properties at different hybrid ratios and different temperatures were studied.
Based on the hybrid effect and temperature effect, the impact failure mechanism of the sample was analyzed.
Study on bulletproof performance of functionalized fabrics modified by microcapsules
Authors: Li Runhan , Yan Ke , Wang Tao , Wu Hao , Chen Hao , Qian Xinming , Yuan Mengqi , Qi Shaobo 
Published: April 2024

AbstractThe incorporation of microcapsule particles (MPs) into fabrics offers the potential to enhance both the friction between fabric yarns and the bulletproof impact performance. In this study, MPs were prepared using the interfacial polymerization method. Furthermore, an innovative modification of the AF fabric was achieved by introducing a silane coupling agent and MPs. This resulted in the development of a microcapsules‐aramid fibers (MPs‐AF) composite material exhibiting excellent protective performance. The characterization experiment demonstrated the successful adhesion of MPs to the AF fabric, forming a robust bond between the fiber and the particles. Importantly, the modification process did not have any adverse effects on the fiber structure. The study further investigated the ballistic performance and protection mechanism of the modified fabrics through mechanical performance tests and ballistic impact tests. The yarn pull‐out experiment revealed that the MPs‐AF composite material exhibited a significant increase in pull‐out force, with a remarkable improvement of 175.6% compared to AF fabric. In the ballistic impact experiments, the MPs‐AF composite material demonstrated a substantial increase in ballistic limit velocity, rising from 52 to 118 m/s when compared to the AF fabric. These findings highlight the potential application of the MPs‐AF composite material in the field of wearable protection.Highlights
Fiber surface modification grafting reaction.
A simple and novel solution impregnation method was used to prepare modified AF.
Preparation of microcapsule particles by interfacial polymerization.
Green new fiber bulletproof material.
Chemical grafting produces strong chemical bonds to increase interfacial resistance.
Resistance‐type strain sensor based on carbon nanofiber/polypyrrole composite membrane with high sensitivity
Authors: Zhang Zeyu , Li Ziheng , Zhang Mingxue , Hao Hongshun , Yan Shuang 
Published: April 2024

AbstractCarbon nanofibers have been widely studied as one of the promising materials for fabricating flexible electronic strain sensors. Surface modification of carbon nanofibers by conducting polymers is a simple yet effective approach to constructing strain sensors with good conductivity and sensitivity. In this work, composite nanofiber membranes composed of carbon nanofiber and conducting polymer are developed via in situ polymerization of pyrrole, aniline, and thiophene respectively on the surface of the carbon nanofiber which serves as a substrate. Different composite membranes, CNF@PANI, CNF/Ppy, and CNF@PTh, are successfully manufactured. The conducting polymer‐carbon nanofiber composite membranes exhibit improved conductivity as well as response sensitivity compared to pristine carbon nanofiber membranes. Among different composite membranes being studied, CNF/Ppy demonstrates the highest strain‐sensing performance. It shows good sensitivity, reproducibility, and stability in detecting both subtle (strain = 0.1%) and large (strain = 25%) deformation. The excellent strain‐sensing performance of CNF/Ppy endows the composite membrane with great potential for applications in wearable electronics.Highlights
Adding PANI, Ppy, and PTh could improve the conductivity of the CNF sensor.
Ppy doping has a good effect on the performance of the CNF strain sensor.
CNF/Ppy strain sensor has high sensitivity, stability, and durability.
CNF/Ppy sensors can detect deformation caused by human movement.
CP‐CNF composite material has good flexibility and mechanical properties.
Validating claims‐based definitions for deprescribing: Bridging the gap between clinical and administrative data
Authors: Niznik Joshua D. , Shmuel Shahar , Pate Virginia , Thorpe Carolyn T. , Hanson Laura C. , Rice Colleen , Lund Jennifer L. 
Published: April 2024

AbstractBackgroundLimited research has evaluated the validity of claims‐based definitions for deprescribing.ObjectivesEvaluate the validity of claims‐based definitions of deprescribing against electronic health records (EHRs) for deprescribing of benzodiazepines (BZDs) after a fall‐related hospitalization.MethodsWe used a novel data linkage between Medicare fee‐for‐service (FFS) and Part D with our health system's EHR. We identified patients aged ≥66 years with a fall‐related hospitalization, continuous enrollment in Medicare FFS and Part D for 6 months pre‐ and post‐hospitalization, and ≥2 BZD fills in the 6 months pre‐hospitalization. Using a standardized EHR abstraction tool, we adjudicated deprescribing for a sub‐sample with a fall‐related hospitalization at UNC. We evaluated the validity of claims‐based deprescribing definitions (e.g., gaps in supply, dosage reductions) versus chart review using sensitivity and specificity.ResultsAmong 257 patients in the overall sample, 44% were aged 66–74 years, 35% had Medicare low‐income subsidy, 79% were female. Among claims‐based definitions using gaps in supply, the prevalence of BZD deprescribing ranged from 8.2% (no refills) to 36.6% (30‐day gap). When incorporating dosage, the prevalence ranged from 55.3% to 65.8%. Among the validation sub‐sample (n = 47), approximately one‐third had BZDs deprescribed in the EHR. Compared to EHR, gaps in supply from claims had good sensitivity, but poor specificity. Incorporating dosage increased sensitivity, but worsened specificity.ConclusionsThe sensitivity of claims‐based definitions for deprescribing of BZDs was low; however, the specificity of a 90‐day gap was >90%. Replication in other EHRs and for other low‐value medications is needed to guide future deprescribing research.
Practices and perspectives on advanced diagnostic and interventional bronchoscopy among pediatric pulmonologists in the United States
Authors: Corcoran A. , Shore D. , Boesch R. P. , Chopra M. , Das S. , DiBardino D. , Goldfarb S. , Haas A. , Hysinger E. , Phinizy P. , Vicencio A. , Toth J. , Piccione J. 
Published: April 2024

AbstractIntroductionAdvanced diagnostic bronchoscopy includes endobronchial ultrasound (EBUS) guided transbronchial lung and lymph node biopsies, CT navigation and robotic bronchoscopy. Interventional bronchoscopy refers to procedures performed for therapeutic purposes such as balloon dilation of the airway, tissue debulking, cryotherapy, removal of foreign bodies and insertion of endobronchial valves [1]. For adult patients, these procedures are standard of care [2, 3]. Despite a lack of formalized training, there are numerous case reports and case series describing the use of advanced diagnostic and interventional bronchoscopy techniques in children. The safety and feasibility of EBUS‐TBNA, cryotherapy techniques, endobronchial valves among other techniques have been demonstrated in these publications [1, 4‐9].MethodsWe sought to better understand the current practices and perspectives on interventional and advanced bronchoscopy among pediatric pulmonologists through surveys sent to pediatric teaching hospitals across the United States.ResultsWe received 43 responses representing 28 programs from 25 states. The highest bronchoscopy procedure volume occurred in the 0‐5 years age group. Among our respondents, 31% self‐identified as a pediatric interventional/advanced bronchoscopist. 79% believe that advanced and interventional training is feasible in pediatric pulmonology and 77% believe it should be offered to pediatric pulmonary fellows.DiscussionThis is the first study to characterize current practices and perspectives regarding advanced diagnostic and interventional bronchoscopy procedures among pediatric pulmonologists in the United States. Pediatric interventional pulmonology (IP) is in its infancy and its beginnings echo those of the adult IP where only certain centers were performing these procedures.
A body shape index (ABSI) but not body mass index (BMI) is associated with prostate cancer‐specific mortality: Evidence from the US NHANES database
Authors: Ku Hui‐Chen , Cheng Evelyn , Cheng Ching‐Feng 
Published: April 2024

AbstractBackgroundProstate cancer (PCa) is a common malignancy in males and obesity may play a role in its development and progression. Associations between visceral obesity measured by a body shape index (ABSI) and PCa mortality have not been thoroughly investigated. This study assessed the associations between ABSI, body mass index (BMI), and long‐term PCa‐specific mortality using a nationally representative US database.MethodsThis population‐based longitudinal study collected data of males aged ≥40 years diagnosed with PCa and who underwent surgery and/or radiation from the National Health and Nutrition Examination Survey database 2001–2010. All included participants were followed through the end of 2019 using the National Center for Health Statistics Linked Mortality File. Associations between PCa‐specific mortality, BMI, and ABSI were determined using Cox proportional hazards regression and receiver operating characteristic (ROC) curve analysis.ResultsData of 294 men (representing 1,393,857 US nationals) were analyzed. After adjusting for confounders, no significant associations were found between BMI (adjusted hazard ratio [aHR] = 1.06, 95% confidence interval [CI]: 0.97–1.16, p = 0.222), continuous ABSI (aHR = 1.29, 95% CI: 0.83–2.02, p = 0.253), or ABSI in category (Q4 vs. Q1–Q3: aHR = 1.52, 95% CI: 0.72–3.24, p = 0.265), and greater risk of PCa‐specific mortality. However, among participants who had been diagnosed within 4 years, the highest ABSI quartile but not in BMI was significantly associated with greater risk for PCa‐specific mortality (Q4 vs. Q1–Q3: aHR = 5.34, 95% CI: 2.26–12.62, p = 0.001). In ROC analysis for this subgroup, the area under the curve of ABSI alone for predicting PCa‐specific mortality was 0.638 (95% CI: 0.448–0.828), reaching 0.729 (95% CI: 0.490–0.968 when combined with other covariates.ConclusionsIn US males with PCa diagnosed within 4 years, high ABSI but not BMI is independently associated with increased PCa‐specific mortality.
Enhancing the anticancer effect of androgen deprivation therapy by monocarboxylate transporter 1 inhibitor in prostate cancer cells
Authors: Kim Jimin , Park Sanghee , Kim Seunghwan , Ryu Seungyeon , Hwang Hyemin , Cho Sua , Han Yeonju , Kim Jisu , Park Yusun , Lee Eun Kyung , Lee Misu 
Published: April 2024

AbstractBackgroundTumor initiation and progression necessitate a metabolic shift in cancer cells. Consequently, the progression of prostate cancer (PCa), a leading cause of cancer‐related deaths in males globally, involves a shift from lipogenic to glycolytic metabolism. Androgen deprivation therapy (ADT) serves as the standard treatment for advanced‐stage PCa. However, despite initial patient responses, castrate resistance emerges ultimately, necessitating novel therapeutic approaches. Therefore, in this study, we aimed to investigate the role of monocarboxylate transporters (MCTs) in PCa post‐ADT and evaluate their potential as therapeutic targets.MethodsPCa cells (LNCaP and C4‐2 cell line), which has high prostate‐specific membrane antigen (PSMA) and androgen receptor (AR) expression among PCa cell lines, was used in this study. We assessed the expression of MCT1 in PCa cells subjected to ADT using charcoal‐stripped bovine serum (CSS)‐containing medium or enzalutamide (ENZ). Furthermore, we evaluated the synergistic anticancer effects of combined treatment with ENZ and SR13800, an MCT1 inhibitor.ResultsShort‐term ADT led to a significant upregulation in folate hydrolase 1 (FOLH1) and solute carrier family 16 member 1 (SLC16A1) gene levels, with elevated PSMA and MCT1 protein levels. Long‐term ADT induced notable changes in cell morphology with further upregulation of FOLH1/PSMA and SLC16A1/MCT1 levels. Treatment with ENZ, a nonsteroidal anti‐androgen, also increased PSMA and MCT1 expression. However, combined therapy with ENZ and SR13800 led to reduced PSMA level, decreased cell viability, and suppressed expression of cancer stem cell markers and migration indicators. Additionally, analysis of human PCa tissues revealed a positive correlation between PSMA and MCT1 expression in tumor regions.ConclusionsOur results demonstrate that ADT led to a significant upregulation in MCT1 levels. However, the combination of ENZ and SR13800 demonstrated a promising synergistic anticancer effect, highlighting a potential therapeutic significance for patients with PCa undergoing ADT.
Germacrone alleviates breast cancer‐associated osteolysis by inhibiting osteoclastogenesis via inhibition of MAPK/NF‐κB signaling pathways
Authors: Lin Zhengjun , Yang Yaocheng , Liu Tang , Wu Ziyi , Zhang Xianghong , Yang Jing 
Published: April 2024

AbstractBone is one of the most frequent sites for metastasis in breast cancer patients. Bone metastasis significantly reduces the survival time and the life quality of breast cancer patients. Germacrone (GM) can serve humans as an anti‐cancer and anti‐inflammation agent, but its effect on breast cancer‐induced osteolysis remains unclear. This study aims to investigate the functions and mechanisms of GM in alleviating breast cancer‐induced osteolysis. The effects of GM on osteoclast differentiation, bone resorption, F‐actin ring formation, and gene expression were examined in vitro. RNA‐sequencing and Western Blot were conducted to explore the regulatory mechanisms of GM on osteoclastogenesis. The effects of GM on breast cancer‐induced osteoclastogenesis, and breast cancer cell malignant behaviors were also evaluated. The in vivo efficacy of GM in the ovariectomy model and breast cancer bone metastasis model with micro‐CT and histomorphometry. GM inhibited osteoclastogenesis, bone resorption and F‐actin ring formation in vitro. Meanwhile, GM inhibited the expression of osteoclast‐related genes. RNA‐seq analysis and Western Blot confirmed that GM inhibited osteoclastogenesis via inhibition of MAPK/NF‐κB signaling pathways. The in vivo mouse osteoporosis model further confirmed that GM inhibited osteolysis. In addition, GM suppressed the capability of proliferation, migration, and invasion and promoted the apoptosis of MDA‐MB‐231 cells. Furthermore, GM could inhibit MDA‐MB‐231 cell‐induced osteoclastogenesis in vitro and alleviate breast cancer‐associated osteolysis in vivo human MDA‐MB‐231 breast cancer bone metastasis‐bearing mouse models. Our findings identify that GM can be a promising therapeutic agent for patients with breast cancer osteolytic bone metastasis.