bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF PERINATAL IRON DEFICIENCY ON BEHAVIORAL DEVELOPMENTS AND MYELINATION AROUND THE HIPPOCAMPUS IN RATS
Authors: Wu Lingling , Zhang Li , Shao Jie , Zhao Zhengyan 
Published: January 2008

INTRODUCTION: Iron deficiency is a common nutritional disorder. The effect of iron deficiency on myelination of specific brain regions and their relevant behavior has not been well documented.
OBJECTIVE: The objective of this study was to determine the consequences of perinatal iron deficiency on behavioral and myelination of specific brain regions in rats.
METHODS: Sixteen dams were randomly assigned to iron-sufficient or low-iron diets during gestation and lactation. Thereafter, all offspring were fed the iron-sufficient diet and were assessed for behavioral and neurologic developments. Behavioral assessments included sensorimotor function tests, a recognition memory task, and a spatial learning task. The density of myelination around the hippocampus was measured by 2`,3`-cyclic nucleotide 3`-phosphohydrolase (marker of oligodendrocyte) by means of immunohistochemistry and quantified by analysis of integrated optical density. The regions of interest included the corpus callosum and the fimbria of the hippocampus.
RESULTS: Iron-deficient rats showed behavioral impairments in sensorimotor functions and recognition memory task but no significant differences were found in the spatial learning task. Iron-deficient rats had significantly reduced density of myelination than control rats in the corpus callosum but had no difference in the fimbria of the hippocampus.
CONCLUSIONS: This study shows that perinatal iron deficiency can significantly alter the behavioral outcomes in rat pups and can profoundly influence the development of myelination in specific brain regions.
HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR THE TREATMENT OF THALASSEMIA: THE GREEK EXPERIENCE
Authors: Peristeri Ioulia , Kitra Vassiliki , Goussetis Evgenios , Vessalas Georgios , Theodosaki Maria , Paisiou Anna , Petrakou Eftychia , Graphakos Stelios 
Published: January 2008

INTRODUCTION: Although prevention remains the cornerstone for the management of thalassemia, hematopoietic stem cell transplantation (HSCT) is the only curative approach.
OBJECTIVE: Our goal was to assess our experience with HSCTs for the treatment of patients with thalassemia.
METHODS: From 1994 to 2006, 96 HSCTs have been performed in 84 thalassemic children from Greece, 3 with sickle cell/thalassemia and 1 with sickle cell disease. According to Pesaro classification, of these 84 children, 20 were in class I, 35 were in class II, and 29 were in class III. Donors were 84 histocompatible siblings and 4 unrelated volunteers. The graft was of bone marrow in 85, cord blood in 3, bone marrow and cord blood in 4, and peripheral blood stem cells in 4. The conditioning regimen consisted of busulfan, cyclophosphamide, and antilymphocyte globulin.
RESULTS: All except 1 patient received engraftments. Ten patients rejected the graft. Eight received another transplant from the same donor, 7 of which were successful. Four patients died; causes of death were graft-versus-host disease (GVHD) (2), disseminated toxoplasmosis (1), and brain hemorrhage (1). At a median follow-up time of 6.5 years, 84 of 88 children survived, 81 were cured and free from transfusions, and 3 remained transfusion-dependent. Severe acute GVHD developed in 18 children, and chronic GVHD developed in 8 patients. The overall survival rate, event-free survival rate, rejection rate, and transplant-related mortality rate were 95%, 94%, 11%, and 5%, respectively. Event-free survival was 100% for class I, 95% for class II, and 87% for class III. Eleven children had mixed chimera (residual recipient hematopoiesis) with normal levels of hemoglobin.
CONCLUSIONS: HSCT is a highly effective treatment for thalassemic patients who have a fully matched donor (related or unrelated). Younger age at transplant secures excellent results with reduced morbidity and mortality rates.
HEALTH NEEDS OF CHILDREN LIVING IN OUT-OF-HOME CARE
Authors: Tzioumi Dimitra , Nathanson Dania 
Published: January 2008

INTRODUCTION: Children in out-of-home care have high, unrecognized, and unmet health needs. The combination of exposure to abuse and neglect and a background of social disadvantage place them at significant risk for poor health, which affects their physical, developmental, and emotional health.
OBJECTIVE: The aim of this study was to screen children in out-of-home care for unidentified health problems and recommend appropriate health interventions.
METHODS: A health screening clinic for children in out-of-home care was established in a tertiary children's hospital in 2005 in collaboration with social services. Working within a multidisciplinary framework, the children had a comprehensive physical, developmental, and behavioral health screen. Recommendations were made to social services for appropriate health care.
RESULTS: Of the 122 children screened, 24% had incomplete immunizations, 20% had visual problems, 30% had dental problems, and 26% had hearing loss, 45% of the children under 5 years of age had speech delay, 60% failed the developmental screen, and 54% had significant behavioral and emotional problems.
CONCLUSIONS: Children in out-of-home care are a vulnerable group of the child population who experience unacceptable levels of poor health. Comprehensive health screens are important for identifying previously undetected health problems and recommending appropriate health interventions.
A Comparison of the Completeness and Timeliness of Automated Electronic Laboratory Reporting and Spontaneous Reporting of Notifiable Conditions
Authors: Overhage J. Marc , Grannis Shaun , McDonald Clement J. 
Published: January 2008

Objectives. We examined whether automated electronic laboratory reporting of notifiable-diseases results in information being delivered to public health departments more completely and quickly than is the case with spontaneous, paper-based reporting. Methods. We used data from a local public health department, hospital infection control departments, and a community-wide health information exchange to identify all potential cases of notifiable conditions that occurred in Marion County, Ind, during the first quarter of 2001. We compared traditional spontaneous reporting to the health department with automated electronic laboratory reporting through the health information exchange. Results. After reports obtained using the 2 methods had been matched, there were 4785 unique reports for 53 different conditions during the study period. Chlamydia was the most common condition, followed by hepatitis B, hepatitis C, and gonorrhea. Automated electronic laboratory reporting identified 4.4 times as many cases as traditional spontaneous, paper-based methods and identified those cases 7.9 days earlier than spontaneous reporting. Conclusions. Automated electronic laboratory reporting improves the completeness and timeliness of disease surveillance, which will enhance public health awareness and reporting efficiency.
Short-Term Impact Evaluation of a Social Marketing Campaign to Prevent Syphilis Among Men Who Have Sex With Men
Authors: Darrow William W. , Biersteker Susan 
Published: January 2008

Objectives. We carried out an independent short-term impact evaluation of a social marketing campaign designed to reduce syphilis infections among men who have sex with men in south Florida in 2004. Methods. Venue-based surveys were conducted shortly after the campaign began and 6 months later to assess changes in exposure to campaign materials, awareness, knowledge about syphilis, perceptions of risk, sexual behavior, clinic visits, and testing and treatment for syphilis among participants. Results. Exposure to social marketing campaign materials increased from 18.0% at baseline to 36.5% at follow-up (P< .001). Awareness of syphilis and perceptions of risk increased among Broward County residents but not among Miami–Dade County residents. Risky sexual practices and patterns of recreational drug use did not change. No significant increases in knowledge, clinic visits, or testing or treatment for syphilis among participants were detected over the 6-month study period. Conclusions. None of the campaign objectives were fully met. The interventions were insufficient to produce a significant impact among men who have sex with men in south Florida.
Cs‐Doped and Cs‐S Co‐Doped CuI p‐Type Transparent Semiconductors with Enhanced Conductivity
Authors: Mirza Adeem S. , Vishal Badri , Dally Pia , Schnohr Claudia S. , De Wolf Stefaan , Morales‐Masis Monica 
Published: April 2024

AbstractOne hindrance in transparent electronics is the lack of high‐performance p‐type transparent conductors (TCs). The state‐of‐the‐art p‐type TC, CuI, has a conductivity two orders of magnitude lower than n‐type TCs like ITO. While doping strategies have shown promise in enhancing the hole carrier density in CuI, they often come at the expense of hole mobility. Therefore, understanding how extrinsic dopants affect the mobility of CuI is critical to further improve the performance of CuI‐based TCs. Here the structural and electronic properties of Cs‐doped CuI are investigated. It is demonstrated that ≈4 at.% Cs doping in CuI increases the carrier density from 2.1 × 1019 to 3.8 × 1020 cm−3 while preserving the film microstructure and local coordination of Cu, as confirmed by HRTEM and XAS analysis. Introducing S as a co‐dopant in Cs:CuI boosts the carrier density to 8.2 × 1020 cm−3, reaching a stable conductivity of ≈450 S cm−1. In all cases, the enhanced carrier density negatively affects the hole mobility with ionized impurity scattering and increased Seebeck hole effective mass as mobility limiting mechanisms. Nonetheless, the new Cs, S co‐doped CuI exhibits high p‐type conductivity, Vis–NIR transparency, and stability, presenting an attractive candidate for future transparent electronic devices.
Prevented Cell Clusters’ Migration Via Microdot Biomaterials for Inhibiting Scar Adhesion
Authors: Zhuang Yaping , Lin Feng , Xiang Lei , Cai Zhengwei , Wang Fei , Cui Wenguo 
Published: April 2024

AbstractCluster‐like collective cell migration of fibroblasts is one of the main factors of adhesion in injured tissues. In this research, a microdot biomaterial system is constructed using α‐helical polypeptide nanoparticles and anti‐inflammatory micelles, which are prepared by ring‐opening polymerization of α‐amino acids‐N‐carboxylic anhydrides (NCAs) and lactide, respectively. The microdot biomaterial system slowly releases functionalized polypeptides targeting mitochondria and promoting the influx of extracellular calcium ions under the inflammatory environment, thus inhibiting the expression of N‐cadherin mediating cell–cell interaction, and promoting apoptosis of cluster fibroblasts, synergistically inhibiting the migration of fibroblast clusters at the site of tendon injury. Meanwhile, the anti‐inflammatory micelles are celecoxib (Cex) solubilized by PEG/polyester, which can improve the inflammatory microenvironment at the injury site for a long time. In vitro, the microdot biomaterial system can effectively inhibit the migration of the cluster fibroblasts by inhibiting the expression of N‐cadherin between cell–cell and promoting apoptosis. In vivo, the microdot biomaterial system can promote apoptosis while achieving long‐acting anti‐inflammation effects, and reduce the expression of vimentin and α‐smooth muscle actin (α‐SMA) in fibroblasts. Thus, this microdot biomaterial system provides new ideas for the prevention and treatment of tendon adhesion by inhibiting the cluster migration of fibroblasts.
Stabilizing Interfacial Behaviors of Ni‐rich Cathodes by Upcycling of Oyster Shells Waste
Authors: Heo Jun Won , Jung Jae Woo , Kim Jang Kyun , Yim Taeeun 
Published: April 2024

AbstractLayered lithium oxides (LNCM), with over 60% Ni, are promising cathode materials for electric vehicles due to their high capacity. however, reliable cycling retention cannot easily achieved owing to the instability of the interface. Here, recycled oyster shell (OS) is employed as an efficient precursor for the surface modification of LNCM cathodes; subsequently, Ca‐based artificial cathode–electrolyte interphases (CEI) are obtained at the LNCM interfaces through a simple calcination process. When the pulverized OS is calcined with LNCM cathode materials at elevated temperatures, CaCO3 is converted to CaO via thermal decomposition at the LNCM interface, which effectively protects the unstable interface. Microscopic analyses indicate the nanodomain island‐type CEI layers embedded after OS calcination. The OS‐coated LNCM cathode materials increase the cycling retention after 100 cycles (93.8% vs. 62.7%) and decrease the internal cell pressure by preventing electrolyte decomposition. Incorporating Ca into the LNCM cathode materials also inhibits microcrack formation because of the improvement in particle hardness and the remarkable decrease in the irreversible dissolution of transition metals from LNCM cathodes, considering that Ca plays a crucial role in scavenging fluoride species. Consequently, recycling OS as a functional LNCM precursor is an innovative approach for enhanced cycling retention.
Partial Exsolution Enables Superior Bifunctionality of Ir@SrIrO3 for Acidic Overall Water Splitting
Authors: Zhao Ling , Tao Zetian , You Maosheng , Xiao Huangwei , Wang Sijiao , Ma Wenjia , Huang Yonglong , He Beibei , Chen Qi 
Published: April 2024

AbstractThe pursuit of efficient and durable bifunctional electrocatalysts for overall water splitting in acidic media is highly desirable, albeit challenging. SrIrO3 based perovskites are electrochemically active for oxygen evolution reaction (OER), however, their inert activities toward hydrogen evolution reaction (HER) severely restrict the practical implementation in overall water splitting. Herein, an Ir@SrIrO3 heterojunction is newly developed by a partial exsolution approach, ensuring strong metal‐support interaction for OER and HER. Notably, the Ir@SrIrO3‐175 electrocatalyst, prepared by annealing SrIrO3 in 5% H2 atmosphere at 175 °C, delivers ultralow overpotentials of 229 mV at 10 mA cm−2 for OER and 28 mV at 10 mA cm−2 for HER, surpassing most recently reported bifunctional electrocatalysts. Moreover, the water electrolyzer using the Ir@SrIrO3‐175 bifunctional electrocatalyst demonstrates the potential application prospect with high electrochemical performance and excellent durability in acidic environment. Theoretical calculations unveil that constructing Ir@SrIrO3 heterojunction regulates interfacial electronic redistribution, ultimately enabling low energy barriers for both OER and HER.
Universal crRNA Acylation Strategy for Robust Photo‐Initiated One‐Pot CRISPR–Cas12a Nucleic Acid Diagnostics
Authors: Liu Pengfei , Lin Yating , Zhuo Xiaohua , Zeng Jiayu , Chen Bolin , Zou Zhen , Liu Guhuan , Xiong Erhu , Yang Ronghua 
Published: April 2024

AbstractSpatiotemporal regulation of clustered regularly interspaced short palindromic repeats (CRISPR) system is attractive for precise gene editing and accurate molecular diagnosis. Although many efforts have been made, versatile and efficient strategies to control CRISPR system are still desirable. Here, we proposed a universal and accessible acylation strategy to regulate the CRISPR–Cas12a system by efficient acylation of 2′‐hydroxyls (2′‐OH) on crRNA strand with photolabile agents (PLGs). The introduction of PLGs confers efficient suppression of crRNA function and rapid restoration of CRISPR–Cas12a reaction upon short light exposure regardless of crRNA sequences. Based on this strategy, we constructed a universal PhotO‐Initiated CRISPR–Cas12a system for Robust One‐pot Testing (POIROT) platform integrated with recombinase polymerase amplification (RPA), which showed two orders of magnitude more sensitive than the conventional one‐step assay and comparable to the two‐step assay. For clinical sample testing, POIROT achieved high‐efficiency detection performance comparable to the gold‐standard quantitative PCR (qPCR) in sensitivity and specificity, but faster than the qPCR method. Overall, we believe the proposed strategy will promote the development of many other universal photo‐controlled CRISPR technologies for one‐pot assay, and even expand applications in the fields of controllable CRISPR‐based genomic editing, disease therapy, and cell imaging.
A novel preassigned‐time sliding mode control method for synchronization of T‐S fuzzy stochastic complex networks with time‐varying delay
Authors: Wang Tong , Zhao Feng , Chen Xiangyong , Qiu Jianlong 
Published: April 2024

AbstractThis paper investigates the finite‐time synchronization issue of Takagi‐Sugeno (T‐S) fuzzy stochastic complex networks (TSFSCN) with disturbances and time‐varying delays using the preassigned‐time sliding mode control (SMC) strategy. A novel fuzzy SMC law is designed by introducing a time‐varying function, ensuring that the error system reaches the sliding mode surface (SMS) within any preassigned time and converges to zero along the SMS. The arrival time and sliding time are independent of design parameters and initial values, enhancing the stability and controllability of the system. Additionally, the adoption of a continuous function to replace the sign function reduces the chattering phenomenon in the system. Based on Lyapunov theory and finite‐time SMC strategy, a sufficient condition is derived for the system to achieve arbitrary preassigned‐time synchronization. Finally, the effectiveness of the proposed control method is verified through two examples.
Expression of filaments of theGeobacterextracellular cytochrome OmcS inShewanella oneidensis
Authors: Lin Tong , Ding Wenqi , Zhang Danni , You Zixuan , Yang Yun , Li Feng , Xu Dake , Lovley Derek R. , Song Hao 
Published: March 2024

AbstractThe physiological role ofGeobacter sulfurreducensextracellular cytochrome filaments is a matter of debate and the development of proposed electronic device applications of cytochrome filaments awaits methods for large‐scale cytochrome nanowire production. Functional studies inG. sulfurreducensare stymied by the broad diversity of redox‐active proteins on the outer cell surface and the redundancy and plasticity of extracellular electron transport routes.G. sulfurreducensis a poor chassis for producing cytochrome nanowires for electronics because of its slow, low‐yield, anaerobic growth. Here we report that filaments of theG. sulfurreducenscytochrome OmcS can be heterologously expressed inShewanella oneidensis. Multiple lines of evidence demonstrated that a strain ofS. oneidensis, expressing theG. sulfurreducensOmcS gene on a plasmid, localized OmcS on the outer cell surface. Atomic force microscopy revealed filaments with the unique morphology of OmcS filaments emanating from cells. Electron transfer to OmcS appeared to require a functional outer‐membrane porin‐cytochrome conduit. The results suggest thatS. oneidensis, which grows rapidly to high culture densities under aerobic conditions, may be suitable for the development of a chassis for producing cytochrome nanowires for electronics applications and may also be a good model microbe for elucidating cytochrome filament function in anaerobic extracellular electron transfer.
The interplay of institutional pressures, digitalization capability, environmental, social, and governance strategy, and triple bottom line performance: A moderated mediation model
Authors: Lee Min‐Jae , Pak Anna , Roh Taewoo 
Published: March 2024

AbstractThis study seeks to elucidate the mediating role of environmental, social, and governance strategy (ESGS) in bridging the nexus between institutional pressures—specifically regulatory and stakeholder influences—and triple bottom line performance (TBLP), which encompasses economic, social, and environmental facets. Concurrently, this study examines the extent to which digitalization capability influences these dynamics. Utilizing a dataset from subsidiaries within China's retail and transportation sectors, we employed structural equation modeling alongside regression analysis to validate our hypotheses. The findings corroborate a partial mediating effect of ESGS on the TBLP in response to institutional pressures while highlighting digitalization capabilities' moderated mediation role in strengthening the relationship between institutional pressures and TBL through ESGS implementation. By weaving together institutional theory and dynamic capability perspectives, this study advances the understanding of strategic avenues that influence TBLP through ESGS and offers managerial insights for effectively leveraging ESG strategies.
Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC
Authors: Yu Shuo , Ren Hui , Liu Tingting , Han Xiaoyan , Guo Hui , Ning Qian , Li Yang , Zhou Hong , Chen Mingwei , Hu Tinghua 
Published: April 2024

AbstractObjectiveNon‐small‐cell lung cancer (NSCLC) is a deadly form of cancer that exhibits extensive intercellular communication which contributed to chemoradiotherapy resistance. Recent evidence suggests that arrange of key proteins are involved in lung cancer progression, including gap junction proteins (GJPs).Methods and ResultsIn this study, we examined the expression patterns of GJPs in NSCLC, uncovering that both gap junction protein, beta 2 (GJB2) and gap junction protein, beta 2 (GJB3) are increased in LUAD and LUSC. We observed a correlation between the upregulation of GJB2, GJB3 in clinical samples and a worse prognosis in patients with NSCLC. By examining the mechanics, we additionally discovered that nuclear factor erythroid‐2‐related factor 1 (NFE2L1) had the capability to enhance the expression of connexin26 and connexin 31 in the NSCLC cell line A549. In addition, the use of metformin was discovered to cause significant downregulation of gap junction protein, betas (GJBs) by limiting the presence of NFE2L1 in the cytoplasm.ConclusionThis emphasizes the potential of targeting GJBs as a viable treatment approach for NSCLC patients receiving metformin.
Facial emotion recognition with a reduced feature set for video game and metaverse avatars
Authors: Bellenger Darren , Chen Minsi , Xu Zhijie 
Published: April 2024

AbstractThis paper presents a novel real‐time facial feature extraction algorithm, producing a small feature set, suitable for implementing emotion recognition with online game and metaverse avatars. The algorithm aims to reduce data transmission and storage requirements, hurdles in the adoption of emotion recognition in these mediums. The early results presented show a facial emotion recognition accuracy of up to 92% on one benchmark dataset, with an overall accuracy of 77.2% across a wide range of datasets, demonstrating the early promise of the research.