bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐life users of hormonal or thermal male contraception: An analysis of female partners’ motivation, experience, and satisfaction
Authors: Laurent Clothilde , Mieusset Roger , Soufir Jean‐Claude , Perrin Jeanne 
Published: February 2024

AbstractBackgroundTwo male contraceptive methods that inhibit spermatogenesis currently exist: thermal male contraception and hormonal male contraception. Only five studies have been conducted on the acceptability of these methods among men; among women, only the hypothetical acceptability of such a male contraceptive approach as the sole contraception method used by a couple has been evaluated.ObjectivesTo evaluate the motivation, experience, and satisfaction of female partners in couples using hormonal male contraception or thermal male contraception as the sole contraception.Materials and methodsIn this cross‐sectional study, 123 male users of hormonal male contraception or thermal male contraception as the couple's sole contraception method were asked to invite their female partner to participate in an anonymous online survey. The questionnaire included 95 questions exploring population characteristics, contraceptive and pregnancy history, motivations for choosing hormonal male contraception or thermal male contraception, the experience of the women in the successive phase of use, relationships with their partner, and satisfaction with the contraception method.ResultsThe response rate among participating women was 69% (59/86). The two main reasons for choosing male contraceptive were the desire to share the contraception role in the couple (65%) and the desire of the man to take charge of the contraception (61%). The sexual satisfaction score increased significantly between the contraceptive methods used before hormonal male contraception or thermal male contraception and the phase of contraceptive use (p < 0.01). The overall satisfaction level with thermal male contraception or hormonal male contraception was rated at 3.7 ± 0.6 out of 4. Women mostly recommended hormonal male contraception or thermal male contraception because of the share of contraceptive responsibility and mental load (n = 23/54, 43%).DiscussionThis population of women seemed to have struggled to find a contraceptive method that suited them, but most took advantage of thermal male contraception or hormonal male contraception and trusted their male partner to take charge of contraception use.ConclusionThe positive evaluation from women in partnerships using thermal male contraception and hormonal male contraception should encourage the development of these methods.
ABO non‐identical platelet transfusions, immune platelet refractoriness and platelet support
Authors: Han Min‐Hi , Badami Krishna Govind 
Published: February 2024

SummaryABO‐non‐identical (ABO‐ni) platelets may be another risk factor for immune platelet transfusion refractoriness (i‐PTR). We examined the effect of such platelets on i‐PTR and subsequent platelet support through retrospective analysis of 17 322 New Zealand patients receiving ≥1 platelets. Immune PTR was defined as PTR with anti‐HLA‐I/HPA positivity. Univariate and multivariate analyses determined the independent risk factors for i‐PTR. One hundred and eighty‐eight patients (1.1%) had i‐PTR and received more ABO‐ni platelets than non‐refractory patients (53.2% vs. 29.5%; p < 0.001). More non‐O than group O patients had received ABO‐ni platelets before i‐PTR diagnosis (67.6% vs. 32.5%; p < 0.001). Female sex (p < 0.001), age ≤ 60 years (p = 0.004), haematology patients (p < 0.001) and ≥2 ABO‐ni platelets (p < 0.001) were the independent risk factors for i‐PTR. More i‐PTR patients with anti‐HLA‐I were non‐O compared to group O (90.1% vs. 75.3%; p = 0.007). More with anti‐HLA‐I + anti‐HPA were group O than non‐O (24.7% vs. 9.0%; p = 0.003). ABO‐ni platelet‐exposed i‐PTR patients required matched platelets for longer than those receiving only ABO‐i platelets (96.5 vs. 59.0 days; p = 0.02). ABO‐ni platelets may be a risk factor for i‐PTR with dose effect. ABO‐i platelets should be considered whenever possible for at‐risk patients.
First complete remission favours haploidentical haematopoietic stem cell transplantation with post‐transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia
Authors: Jo Tomoyasu , Ueda Tomoaki , Akahoshi Yu , Kondo Tadakazu , Uchida Naoyuki , Tanaka Masatsugu , Nakamae Hirohisa , Doki Noriko , Ota Shuichi , Sawa Masashi , Ohigashi Hiroyuki , Maruyama Yumiko , Takayama Nobuyuki , Nishida Tetsuya , Hiramoto Nobuhiro , Katayama Yuta , Kanda Yoshinobu , Ichinohe Tatsuo , Atsuta Yoshiko , Arai Yasuyuki ,   the Japanese Society for Transplantation and Cellular Therapy (JSTCT)
Published: February 2024

SummaryTo assess the benefits of HLA‐haploidentical haematopoietic stem cell transplantation using post‐transplant cyclophosphamide (PTCy‐haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy‐haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy‐haplo was associated with a significantly higher relapse rate, but lower non‐relapse mortality, which results in overall survival and disease‐free survival, comparable to those of UCB. Among patients in CR1, PTCy‐haplo showed a significantly higher survival than UCB regardless of the CD34+ cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.
Employer associations, adaptive innovation and common goods: An integrated framework
Authors: Sheldon Peter , Della Torre Edoardo , Carollo Luca , Nacamulli Raoul 
Published: February 2024

AbstractThis article proposes a new theoretical framework of employer association (EA) adaptive innovation, a strategic organizational response to challenging environments facing EAs and/or relevant firms. Through adaptive innovation, EAs can enlarge their span of service offerings beyond collective, selective and elective goods, services typically explained by Olson‐inspired, market‐transactional theorizing. We identify, explain and conceptualize EA shifts into also offering common goods as community‐building, relational types of collective action. Territorial ecosystems are one prominent new domain for this type of strategic adaptive intervention. In our illustrative case, this involves collectively organizing an open innovation ecosystem beyond an EA's own walls. Ostrom's theorizing on the governance of the commons better explains these initiatives than Olson's. Our new framework, therefore, integrates Ostrom's with Olson's theories. In broadening the field's understanding of EA strategic opportunities, this article also opens prominent lines of inquiry for future EA research.
Distributional ecology: Opening new research windows by addressing aggregation‐related puzzles
Authors: Chen Youhua , Shen Tsung‐Jen 
Published: February 2024

AbstractAimDistribution of species is one of the most elementary but fundamental biodiversity patterns, yet too many puzzles remain unsolved. In most cases, distribution of species is not random, but presents some degree of aggregation. Accordingly, the term ‘distributional aggregation’ is prevailingly used in ecology and evolutionary biology to reflect the non‐random distribution characteristic of species in space and time. However, its meanings are multiform and can be decomposed into a variety of components.LocationGlobal.MethodsIn this paper, through synthesizing historical literature and comparing relevant meanings of distributional aggregation under different contexts, we summarize the current statistical metrics in detecting and evaluating distributional aggregation that are suitable for different field‐survey methods, study models and sampling scales. In particular, we explore the concept under the multi‐species setting for which few conceptual advances and statistical methods have been developed.ResultsWe propose pure data dispersion and spatiotemporal proximity, as two basic components of distributional aggregation. We further explore three advanced components of distributional aggregation: orthogonal, hierarchical and parallel components that can simultaneously link sampling taxa, sampling sites and sampling methods.Main ConclusionsWe hope the systematic review can serve as a potentially useful primer to ecologists for better understanding and investigating complex and new distributional patterns of biological diversity. We further provide informative guides on developing new statistical methods and metrics. We also discuss useful simulation algorithms for generating diverse distributional aggregation patterns of species, aiming to help ecologists to test and compare the performance of different metrics related to diversity and distribution patterns of species.
Long‐term abacus training gains in children are predicted by medial temporal lobe anatomy and circuitry
Authors: Xie Ye , Chang Hyesang , Zhang Yi , Wang Chunjie , Zhang Yuan , Chen Lang , Geng Fengji , Ku Yixuan , Menon Vinod , Chen Feiyan 
Published: February 2024

AbstractAbacus‐based mental calculation (AMC) is a widely used educational tool for enhancing math learning, offering an accessible and cost‐effective method for classroom implementation. Despite its universal appeal, the neurocognitive mechanisms that drive the efficacy of AMC training remain poorly understood. Notably, although abacus training relies heavily on the rapid recall of number positions and sequences, the role of memory systems in driving long‐term AMC learning remains unknown. Here, we sought to address this gap by investigating the role of the medial temporal lobe (MTL) memory system in predicting long‐term AMC training gains in second‐grade children, who were longitudinally assessed up to fifth grade. Leveraging multimodal neuroimaging data, we tested the hypothesis that MTL systems, known for their involvement in associative memory, are instrumental in facilitating AMC‐induced improvements in math skills. We found that gray matter volume in bilateral MTL, along with functional connectivity between the MTL and frontal and ventral temporal‐occipital cortices, significantly predicted learning gains. Intriguingly, greater gray matter volume but weaker connectivity of the posterior parietal cortex predicted better learning outcomes, offering a more nuanced view of brain systems at play in AMC training. Our findings not only underscore the critical role of the MTL memory system in AMC training but also illuminate the neurobiological factors contributing to individual differences in cognitive skill acquisition. A video abstract of this article can be viewed at https://youtu.be/StVooNRc7T8.Research Highlights
We investigated the role of medial temporal lobe (MTL) memory system in driving children's math learning following abacus‐based mental calculation (AMC) training.
AMC training improved math skills in elementary school children across their second and fifth grade.
MTL structural integrity and functional connectivity with prefrontal and ventral temporal‐occipital cortices predicted long‐term AMC training‐related gains.
Insulin resistance before type 2 diabetes onset is associated with increased risk of albuminuria after diabetes onset: A prospective cohort study
Authors: Willig Meeah R. , Stinson Emma J. , Looker Helen C. , Piaggi Paolo , Mitchell Cassie M. , Hanson Robert L. , Nelson Robert G. , Krakoff Jonathan , Chang Douglas C. 
Published: February 2024

AbstractAimReduced renal insulin signalling is implicated in the pathogenesis of albuminuria. We sought to investigate whether insulin action and secretion, measured before diabetes onset, are associated with the development of albuminuria after diabetes onset.Materials and MethodsBaseline body composition, insulin sensitivity by hyperinsulinaemic‐euglycaemic clamp at submaximal and maximal insulin stimulation (240 and 2400 pmol/m2/min; M‐low and M‐high), and insulin secretion by intravenous glucose tolerance test [acute insulin response (AIR)] were measured in 170 Southwestern Indigenous American adults who subsequently developed diabetes. After diabetes onset and during the median follow‐up of 13.6 years, 81 participants (48%) developed albuminuria (urine albumin‐to‐creatinine ratio ≥30 mg/g). Separate associations of M‐low, M‐high and AIR (per 1‐SD change) with the risk of albuminuria were assessed by Cox regression models adjusted for age, sex and body fat (%).ResultsParticipants who developed albuminuria were of similar age (26.4 ± 5.4 vs. 27.5 ± 6.1 years), sex (46% vs. 48% male), body fat (36.4 ± 7.5 vs. 35.7 ± 7.9%) and AIR [2.3 ± 0.3 vs. 2.3 ± 0.3, pmol/L (log)] as those who did not develop albuminuria but had lower insulin sensitivity [M‐low: 0.33 ± 0.08 vs. 0.36 ± 0.12, p = .03; M‐high: 0.87 ± 0.11 vs. 0.91 ± 0.12, p = .02; mg/kg‐metabolic body size/min (log)]. In separate adjusted models, lower M‐low and M‐high were both associated with an increased risk for albuminuria [hazard ratio (HR) 1.51, 95% confidence interval (CI) 1.14, 2.00, p = .004; HR 1.31, 95% CI 1.06, 1.63, p = .01), whereas AIR was not (HR 1.15, 95% CI 0.87, 1.56, p = .3).ConclusionsLower insulin sensitivity is associated with the development of albuminuria, suggesting a role for insulin signalling in the pathogenesis of proteinuria.
Schlick, intuition, and the history of epistemology
Authors: Vrahimis Andreas 
Published: February 2024

AbstractMaria Rosa Antognazza's work has issued a historical challenge to the thesis that the analysis of knowledge (as justified true belief) attacked by epistemologists from Gettier onwards was indeed the standard view traditionally upheld from Plato onwards. This challenge led to an ongoing reappraisal of the historical significance of intuitive knowledge, in which the knower is intimately connected to what is known. Such traditional accounts of intuition, and their accompanying claims to epistemological primacy, constituted the precise target of Moritz Schlick's critique. Schlick engages with this topic throughout his oeuvre, from some of his early epistemological writings, to his anti‐metaphysical stance as a leading Logical Empiricist. Schlick crucially distinguishes knowledge from mere acquaintance, denying that the latter has epistemic status. He therefore argues that the very notion of ‘intuitive knowledge’ is a contradictio in adjecto.
Grading system for assessing the confidence in the epileptogenic zone reported in published studies: A Delphi consensus study
Authors: Ryvlin Philippe , Barba Carmen , Bartolomei Fabrice , Baumgartner Christoph , Brazdil Milan , Fabo Daniel , Fahoum Firas , Frauscher Birgit , Ikeda Akio , Lhatoo Samden , Mani Jayanti , McGonigal Aileen , Metsahonkala Eeva‐Liisa , Mindruta Ioana , Nguyen Dang Khoa , Rheims Sylvain , Rocamora Rodrigo , Rydenhag Bertil , Schuele Stephan , Schulze‐Bonhage Andreas , Surges Rainer , Vulliemoz Serge , Beniczky Sandor 
Published: February 2024

AbstractObjectiveThis study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in the localization of the epileptogenic zone (EZ) as reported in published studies, to harmonize and facilitate systematic reviews in the field of epilepsy surgery.MethodsWe conducted a Delphi study involving 22 experts from 18 countries, who were asked to rate their level of confidence in the localization of the EZ for various theoretical clinical scenarios, using different scales. Information provided in these scenarios included one or several of the following data: magnetic resonance imaging (MRI) findings, invasive electroencephalography summary, and postoperative seizure outcome.ResultsThe first explorative phase showed an overall interrater agreement of .347, pointing to large heterogeneity among experts' assessments, with only 17% of the 42 proposed scenarios associated with a substantial level of agreement. A majority showed preferences for the simpler scale and single‐item scenarios. The successive Delphi voting phases resulted in a majority consensus across experts, with more than two thirds of respondents agreeing on the rating of each of the tested single‐item scenarios. High or very high levels of confidence were ascribed to patients with either an Engel class I or class IA postoperative seizure outcome, a well‐delineated EZ according to all available invasive EEG (iEEG) data, or a well‐delineated focal epileptogenic lesion on MRI. MRI signs of hippocampal sclerosis or atrophy were associated with a moderate level of confidence, whereas a low level was ascribed to other MRI findings, a poorly delineated EZ according to iEEG data, or an Engel class II–IV postoperative seizure outcome.SignificanceThe proposed grading system, based on an expert consensus, provides a simple framework to rate the level of confidence in the EZ reported in published studies in a structured and harmonized way, offering an opportunity to facilitate and increase the quality of systematic reviews and guidelines in the field of epilepsy surgery.
Can a multicomponent positive psychological intervention promote well‐being in parents of young children? A randomized controlled trial study in Hong Kong
Authors: Lee Alfred S. Y. , Datu Jesus Alfonso Daep , Chung Kevin Kien Hoa , Fung Wing Kai , Cheung Ryan Yat Ming 
Published: February 2024

AbstractThe present research examined the effects of an Early Advancement in Social–Emotional Health and Positivity (EASP) multicomponent positive psychological intervention on parents' well‐being in Hong Kong. Participants were parents of young children (N = 120; M
age = 37.19 years, SD = 4.71, range = 24–53; female = 95.00%) who participated in the one‐month randomized control trial. Participants were randomly assigned into the intervention (n = 50) and waitlist control groups (n = 70). Parents in the intervention group received two online workshops and an evidence‐based smartphone application that targeted four positive psychological skills: (1) mindful parenting, (2) hope, (3) positive reappraisal, and (4) growth mindset. The results of the multivariate regression analysis revealed that the intervention significantly improved various dimensions of participants' positive psychological skills, subjective well‐being, and psychological well‐being immediately at the conclusion of the program. The findings of this study underscore the importance of the well‐being payoffs linked to cultivating positive psychological skills among parents of young children.
Beyond salinity: Plants show divergent responses to soil ion composition
Authors: Pätsch Ricarda , Midolo Gabriele , Dítě Zuzana , Dítě Daniel , Wagner Viktoria , Pavonič Michal , Danihelka Jiří , Preislerová Zdenka , Ćuk Mirjana , Stroh Hans Georg , Tóth Tibor , Chytrá Helena , Chytrý Milan 
Published: February 2024

AbstractAimIn salt‐affected environments, salinity shapes ecosystem functions and species composition. Apart from salinity, however, we know little about how soil chemical factors affect plant species. We hypothesized that specific ions, most of which contribute to salinity, co‐determine plant niche differentiation. We asked if the importance of ions differs for species with (halophytes) and without (associated species) physiological adaptations to saline soils.LocationCarpatho‐Pannonian region (Central and Eastern Europe).Time period2005–2021.Major taxa studiedVascular plants.MethodsWe recorded species occurrences and collected soil samples in 433 plots in saline habitats. We measured pH, salinity (electrical conductivity), and concentrations of Ca2+, K+, Mg2+, Na+, SO42− Cl−, CO32− and mineral nitrogen (mN) and calculated the sodium adsorption ratio (SAR). For 88 species, we fitted response curves with Huisman–Olff–Fresco (HOF) models. To study ions' effects on species composition and ions' variance, we compared unconstrained and constrained ordinations and performed a principal component analysis. We used random forests to analyse the importance of ions for individual species and created two‐dimensional species niche plots for key ions.ResultsIon concentration niches varied among species and did not necessarily correspond to soil salinity or alkalinity. We frequently observed monotonic, sigmoidal model responses, while skewed unimodal responses were rare. Ions explained a considerable proportion of species compositional variation. Particularly, Na+, SO42−, Cl−, and CO32− contributed to the ions' variance. Na+, followed by SO42−, Cl−, CO32−, Ca2+, Mg2+, and mN, was most important for the occurrence of individual species. Compared to associated species, Na+, SO42−, and mN were significantly less important for halophytes, whereas Cl− and CO32− played a significant role.Main conclusionsWe show that ion composition co‐determines niche differentiation in saline soils, suggesting evolved physiological adaptations in halophytes. Our study calls for incorporating high‐resolution data on soil ion composition in ecological research.
Risk of colorectal cancer in patients with primary sclerosing cholangitis and concomitant inflammatory bowel disease compared with primary sclerosing cholangitis only
Authors: Das Taranika Sarkar , Ho Kimberly , Udaikumar Jahnavi , Chen Bryan , Delau Olivia , Shaukat Aasma , Jacobson Ira , Sarwar Raiya 
Published: February 2024

AbstractAimPrimary sclerosing cholangitis (PSC) increases the risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients; however, there is a paucity of literature to suggest PSC alone as an independent risk factor for CRC. We aimed to determine if PSC is an independent risk factor for CRC in a large tertiary care medical center. Optimizing screening intervals is of great importance, given the burden and risks associated with a lifetime of colonoscopy screening.MethodsThis retrospective cohort study consists of patients diagnosed with PSC preceding IBD (PSC–IBD) and PSC‐only before January 6, 2023 from a large, tertiary, academic medical center. Patients diagnosed with IBD concurrently or before PSC were excluded to reduce IBD's impact on CRC risk. Demographic data and colonoscopy findings were collected and assessed.ResultsOverall, 140 patients from all NYU Langone Health clinical settings were included. Patients with PSC–IBD were more likely to be diagnosed with CRC (23.3% vs. 1.8%, p < 0.01) and either low‐grade or uncharacterized dysplasia (16.7% vs. 0.0%, p < 0.01) compared with those with PSC‐only. Among PSC‐only patients, the estimated CRC risk was significantly elevated compared with that expected of the standard NYU Langone population (SIR 9.2, 95% CI 1.1, 33.2).ConclusionsOur study revealed a significantly heightened CRC risk in PSC–IBD patients compared with those with PSC‐only. Importantly, individuals with PSC‐only also face a greater CRC risk compared with the general population. Individuals with PSC‐alone may require extended screening and surveillance colonoscopy intervals compared with those with PSC–IBD, yet still require more frequent monitoring than screening guidelines recommend for the general population.