bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinal microglial M1 polarization contributes paclitaxel‐induced neuropathic pain by triggering cells necroptosis
Authors: Dong Yang Ma , Ming Jie Wang , Hui Zhou Li , Zhao Li , Xin Liu , Xiu Li Wang , Shuang Zhao 
Published: March 2024

AbstractPaclitaxel (PTX) is a chemotherapeutic agent that is widely used for the treatment of several types of tumors. However, PTX‐induced peripheral neuropathy (PIPN) is an adverse effect generally induced by long‐term PTX use that significantly impairs the quality of life. Necroptosis has been implicated in various neurodegenerative disorders. Necroptosis of dorsal root ganglion neurons triggers the pathogenesis of PIPN. Therefore, the present study aims to investigate the role of spinal neuronal necroptosis in PIPN. It also explores the potential role of microglial polarization in necroptosis. We established rat models of PIPN via quartic PTX administration on alternate days (accumulated dose: 8 mg/kg). PTX induced obvious neuronal necroptosis and upregulated the expression of receptor‐interacting protein kinase (RIP3) and mixed lineage kinase domain‐like protein (MLKL) in the spinal dorsal horn. These effects were inhibited with a necroptosis pathway inhibitor, necrostatin‐1 (Nec‐1). The effect of microglial polarization on the regulation of spinal necroptosis was elucidated by administering minocycline to inhibit PTX‐induced M1 polarization of spinal microglia caused by PTX. We observed a significant inhibitory effect of minocycline on PTX‐induced necroptosis in spinal cord cells, based on the downregulation of RIP3 and MLKL expression, and suppression of tumor necrosis factor‐α and IL‐β synthesis. Additionally, minocycline improved hyperalgesia symptoms in PIPN rats. Overall, this study suggests that PTX‐induced polarization of spinal microglia leads to RIP3/MLKL‐regulated necroptosis, resulting in PIPN. These findings suggest a potential target for the prevention and treatment of neuropathic pain.
Early versus late caffeine and/or non‐steroidal anti‐inflammatory drugs (NSAIDS) for prevention of intermittent hypoxia‐induced neuroinflammation in the neonatal rat
Authors: Batool Myra , Cai Charles L. , Aranda Jacob V. , Hand Ivan , Beharry Kay D. 
Published: March 2024

AbstractPreterm infants often experience frequent intermittent hypoxia (IH) episodes which are associated with neuroinflammation. We tested the hypotheses that early caffeine and/or non‐steroidal inflammatory drugs (NSAIDs) confer superior therapeutic benefits for protection against IH‐induced neuroinflammation than late treatment. Newborn rats were exposed to IH or hyperoxia (50% O2) from birth (P0) to P14. For early treatment, the pups were administered: 1) daily caffeine (Caff) citrate (Cafcit, 20 mg/kg IP loading on P0, followed by 5 mg/kg from P1‐P14); 2) ketorolac (Keto) topical ocular solution in both eyes from P0 to P14; 3) ibuprofen (Ibu, Neoprofen, 10 mg/kg loading dose on P0 followed by 5 mg/kg/day on P1 and P2); 4) Caff+Keto co‐treatment; 5) Caff+Ibu co‐treatment; or 6) equivalent volume saline (Sal). On P14, animals were placed in room air (RA) with no further treatment until P21. For late treatment, pups were exposed from P0 to P14, then placed in RA during which they received similar treatments from P15‐P21 (Sal, Caff, and/or Keto), or P15‐P17 (Ibu). RA controls were similarly treated. At P21, whole brains were assessed for histopathology, apoptosis, myelination, and biomarkers of inflammation. IH caused significant brain injury and hemorrhage, inflammation, reduced myelination, and apoptosis. Early treatment with Caff alone or in combination with NSAIDs conferred better neuroprotection against IH‐induced damage than late treatment. Early postnatal treatment during a critical time of brain development, may be preferable for the prevention of IH‐induced brain injury in preterm infants.
Synthesis of hydantoins from N‐Boc protected amino acid derived amides using polymer‐supported PPh3/CBr4 as a reagent
Authors: Tasic Gordana , Mitrovic Nikola , Simic Milena , Koravovic Mladen , Jovanovic Predrag , Petkovic Milos , Jovanovic Milos , Ivkovic Branka , Savic Vladimir 
Published: March 2024

AbstractHydantoin derivatives are versatile structural motifs found in natural products and various compounds with different biological or other properties. Due to their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology utilizing N‐Boc protected amino acid amides for their preparation has been described. The cyclisation process was accomplished using solid supported PPh3 and CBr4 as reagents affording substituted hydantoins in moderate to good yields (40%–77%).
Feasibility, Repeatability, and Correlation to Lung Function of Phase‐Resolved Functional Lung (PREFUL) MRI‐derived Pulmonary Artery Pulse Wave Velocity Measurements
Authors: Wernz Marius M. , Voskrebenzev Andreas , Müller Robin A. , Zubke Maximilian , Klimeš Filip , Glandorf Julian , Czerner Christoph , Wacker Frank , Olsson Karen M. , Hoeper Marius M. , Hohlfeld Jens M. , Vogel‐Claussen Jens 
Published: March 2024

BackgroundPulse wave velocity (PWV) in the pulmonary arteries (PA) is a marker of vascular stiffening. Currently, only phase‐contrast (PC) MRI‐based options exist to measure PA‐PWV.PurposeTo test feasibility, repeatability, and correlation to clinical data of Phase‐Resolved Functional Lung (PREFUL) MRI‐based calculation of PA‐PWV.Study TypeRetrospective.Subjects79 (26 female) healthy subjects (age range 19–78), 58 (24 female) patients with chronic obstructive pulmonary disease (COPD, age range 40–77), 60 (33 female) patients with suspected pulmonary hypertension (PH, age range 28–85).Sequence2D spoiled gradient echo, 1.5T.AssessmentPA‐PWV was measured from PREFUL‐derived cardiac cycles based on the determination of temporal and spatial distance between lung vasculature voxels using a simplified (sPWV) method and a more comprehensive (cPWV) method including more elaborate distance calculation. For 135 individuals, PC MRI‐based PWV (PWV‐QA) was measured.Statistical TestsIntraclass‐correlation‐coefficient (ICC) and coefficient of variation (CoV) were used to test repeatability. Nonparametric tests were used to compare cohorts. Correlation of sPWV/cPWV, PWV‐QA, forced expiratory volume in 1 sec (FEV1) %predicted, residual volume (RV) %predicted, age, and right heart catheterization (RHC) data were tested. Significance level α = 0.05 was used.ResultssPWV and cPWV showed no significant differences between repeated measurements (P‐range 0.10–0.92). CoV was generally lower than 15%. COPD and PH patients had significantly higher sPWV and cPWV than healthy subjects. Significant correlation was found between sPWV or cPWV and FEV1%pred. (R = −0.36 and R = −0.44), but not with RHC (P‐range −0.11 − 0.91) or age (P‐range 0.23–0.89). Correlation to RV%pred. was significant for cPWV (R = 0.42) but not for sPWV (R = 0.34, P = 0.055). For all cohorts, sPWV and cPWV were significantly correlated with PWV‐QA (R = −0.41 and R = 0.48).Data ConclusionPREFUL‐derived PWV is feasible and repeatable. PWV is increased in COPD and PH patients and correlates to airway obstruction and hyperinflation.Level of Evidence3Technical EfficacyStage 2
A multi‐objective optimization approach for beam pattern synthesis ofUAVvirtual rectangular antenna array
Authors: Mei Fang , Guo Xinrong , Kang Hui , Sun Geng , Zheng Tingting , Wen Jianbo 
Published: March 2024

AbstractVirtual antenna array (VAA) formed by unmanned aerial vehicle (UAV) antenna units using collaborative beamforming (CB) technology plays an important role in the air communication system, and can be used in radar, military, disaster rescue and other places. However, there are still some issues with the beam pattern formed by this method, such as high sidelobe level (SLL), high cost and low efficiency. In this article, each UAV carries an omnidirectional antenna unit, and a large number of UAVs form a UAV virtual rectangular antenna array (UVRAA) to communicate with the ground base station (BS). We formulate an overhead minimization and efficient communication multi‐objective optimization problem (OMECMOP) which jointly optimize the excitation current weights of the UVRAA and reduce the number of UAVs in operation to improve the beam pattern, enhance the communication efficiency and decrease the overhead of UVRAA. In addition, we also propose an improved multi‐objective multi‐verse optimization algorithm based on the inverse decline curve type (ISDT‐MOMVO) which introduces a strategy optimization initialization solution with quasi‐opposition based learning (QBL) and a hybrid solution updating operators to solve the OMECMOP. The simulation results show that compared with other traditional swarm intelligence (SI) optimization algorithms the ISDT‐MOMVO algorithm produces better beam pattern and the thinning rate can reach 50%.
Assessment of BTI‐induced deterioration in vacuum based undoped structure
Authors: Kumar Rakesh , Panchore Meena 
Published: March 2024

AbstractIn this paper, an assessment of bias temperature instability (BTI) in based dual gate dopingless JLFET (HKV‐DLJLFET) is carried out at 15 nm technology node. For this, the gate dielectric of HKV‐DGDLJLFET is made of asymmetric combination of and vacuum dielectrics near the source/drain (S/D) side, which significantly minimizes the leakage current and enhances the reliability. Our simulation study have shown that the n‐type HKV‐DGDLJLFET exhibits 2.28 and 2.45 times less deterioration in drain current and transconductance respectively, than n‐type HKV‐DGJLFET due to positive BTI (PBTI) for 2000 seconds at . Further, we have found that n‐type HKV‐DGDLJLFET has less deterioration in and due to BTI stress for different time spans. Hence, adding vacuum dielectric to the drain side lowers the BTI stress at high temperatures and makes it last longer.
Quality prediction of whole‐grain rice noodles using backpropagation artificial neural network
Authors: Wang Chujun , Shi Xin , Xue Jianyi , Zhao Siming , Jia Caihua , Niu Meng , Zhang Binjia , Xu Yan 
Published: March 2024

AbstractBACKGROUNDWhole‐grain rice noodles are a kind of healthy food with rich nutritional value, and their product quality has a notable impact on consumer acceptability. The quality evaluation model is of great significance to the optimization of product quality. However, there are few methods that can establish a product quality prediction model with multiple preparation conditions as inputs and various quality evaluation indexes as outputs. In this study, an artificial neural network (ANN) model based on a backpropagation (BP) algorithm was used to predict the comprehensive quality changes of whole‐grain rice noodles under different preparation conditions, which provided a new way to improve the quality of extrusion rice products.RESULTSThe results showed that the BP‐ANN using the Levenberg–Marquardt algorithm and the optimal topology (4‐11‐8) gave the best performance. The correlation coefficients (R2) for the training, validation, testing, and global data sets of the BP neural network were 0.927, 0.873, 0.817, and 0.903, respectively. In the validation test, the percentage error in the quality prediction of whole‐grain rice noodles was within 10%, indicating that the BP‐ANN could accurately predict the quality of whole‐grain rice noodles prepared under different conditions.CONCLUSIONThis study showed that the quality prediction model of whole‐grain rice noodles based on the BP‐ANN algorithm was effective, and suitable for predicting the quality of whole‐grain rice noodles prepared under different conditions. © 2024 Society of Chemical Industry.
Changing the polyphenol composition and enhancing the enzyme activity of sorghum grain by solid‐state fermentation with different microbial strains
Authors: Zhang Duqin , Wang Qi , Li Zhijiang , Shen Zhujiang , Tan Bin , Zhai Xiaotong 
Published: March 2024

AbstractBACKGROUNDSolid‐state fermentation (SSF) has been widely used in the processing of sorghum grain (SG) because it can produce products with improved sensory characteristics. To clarify the influence of different microbial strains on the SSF of SG, especially on the polyphenols content and composition, Lactiplantibacillus plantarum, Saccharomyces cerevisiae, Rhizopus oryzae, Aspergillus oryzae, and Neurospora sitophila were used separately and together for SSF of SG. Furthermore, the relationship between the dynamic changes in polyphenols and enzyme activity closely related to the metabolism of polyphenols has also been measured and analyzed. Microstructural changes observed after SSF provide a visual representation of the SSF on the SG.RESULTSAfter SSF, tannin content (TC) and free phenolic content (FPC) were decreased by 56.36% and 23.48%, respectively. Polyphenol oxidase, β‐glucosidase and cellulase activities were increased 5.25, 3.27, and 45.57 times, respectively. TC and FPC were negatively correlated with cellulase activity. A positive correlation between FPC and xylanase activity after 30 h SSF became negative after 48 h SSF. The SG surface was fragmented and porous, reducing the blocking effect of cortex.CONCLUSIONCellulase played a crucial role in promoting the degradation of tannin (antinutrient) and phenolic compounds. Xylanase continued to release flavonoids while microbial metabolism consumed them with the extension of SSF time. SSF is an effective way to improve the bioactivity and processing characteristics of SG. © 2024 Society of Chemical Industry.
Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract
Authors: Zhang Shimei , Wang An , Lu Zhaoxin , Lu Fengxia , Zhao Haizhen 
Published: March 2024

AbstractBACKGROUNDMillet bran (MB), a byproduct of millet production, is rich in functional components but it is underutilized. In recent years, researchers have shown that fermentation can improve the biological activity of cereals and their byproducts. This study used Bacillus natto to ferment millet bran to improve its added value and broaden the application of MB. The bioactive component content, physicochemical properties, and functional activity of millet bran extract (MBE) from fermented millet bran were determined.RESULTSAfter fermentation, the soluble dietary fiber (SDF) content increased by 92.0%, the β‐glucan content by 164.4%, the polypeptide content by 111.4%, the polyphenol content by 32.5%, the flavone content by 16.4%, and the total amino acid content by 95.4%. Scanning electron microscopy revealed that the microscopic morphology of MBE changed from complete and dense blocks to loosely porous shapes after fermentation. After fermentation, the solubility, water‐holding capacity, and viscosity significantly increased and the particle size decreased. Moreover, the glucose adsorption capacity (2.1 mmol g−1), glucose dialysis retardation index (75.3%), and α‐glucosidase inhibitory (71.4%, mixed reversible inhibition) activity of the fermented MBE (FMBE) were greater than those of the unfermented MBE (0.99 mmol g−1, 32.1%, and 35.1%, respectively). The FMBE presented better cholesterol and sodium cholate (SC) adsorption properties and the adsorption was considered inhomogeneous surface adsorption.CONCLUSIONFermentation increased the bioactive component content and improved the physicochemical properties of MBE, thereby improving its hypoglycemic and hypolipidemic properties. This study not only resolves the problem of millet bran waste but also encourages the development of higher value‐added application methods for millet bran. © 2024 Society of Chemical Industry.
Comparison of Dry Needling and Cold‐Spray‐Stretching Treatments by Ultrasonography and Electrophysiology
Authors: Ustun Busra , Yorulmaz Elem , Geler‐Kulcu Duygu 
Published: March 2024

ObjectivesTo compare the efficacy of dry needling (DN) and cold‐spray‐stretching treatments using surface electromyography (sEMG) and ultrasound (US) in the treatment of patients with myofascial pain syndrome (MPS) with active trigger point (ATrP) in the upper trapezius muscle.MethodsThis prospective randomized single‐blind study included 60 MPS patients aged 18–65 years who have ATrP in the upper trapezius muscle. Patients were randomized into two treatment groups as DN and cold spray stretching. Both treatment groups received 1 treatment per week and totally 3 sessions. Evaluation parameters were pain level assessed by Numeric Rating Scale and algometer, neck range of motion angles, neck disability index (NDI). The effects of the treatments on ATrP were evaluated by sEMG and US histogram. All parameters were evaluated at the beginning of the treatment and at the end. Algometer and sEMG were performed also before and after the first and third sessions.ResultsThere was no significant difference between the two groups regarding demographic data. The mean age of the participants was 39.7 ± 11.6 years. Fifty‐one patients were female. Significant improvement in terms of pain level, functionality, sEMG, and US histogram were achieved in both groups (P < .05). When comparing the two groups, algometer scores and the NDI score were statistically higher in the cold‐spray‐stretching group than in the DN group (P < .008 and P < .028, respectively).ConclusionBoth treatment options should be preferred. The efficacy of both treatments was observed via sEMG and US histograms.
Small RNA Deep Sequencing Uncovers microRNAs Associated with Hearing Loss in Vestibular Schwannoma
Authors: Litwiniuk‐Kosmala Małgorzata , Makuszewska Maria , Niemczyk Kazimierz , Bartoszewicz Robert , Wojtas Bartosz , Gielniewski Bartłomiej 
Published: March 2024

ObjectiveTo analyze the correlation between the miRNA expression profile in vestibular schwannoma (VS) tumor tissue and preoperative patient's hearing status, using the RNA‐seq technique.MethodsNineteen tumor samples were collected from patients operated for VS in a Tertiary Academic Center. Samples were classified into “good hearing” and “poor hearing” study group based on the results of audiometric studies. Tumor miRNA expression was analyzed using high‐throughput RNA sequencing (RNA‐seq) technique, using NovaSeq 6000 Illumina system. Functional analysis was performed with the use of DIANA miRpath v. 4.0 online tool.ResultsThe most overexpressed miRNAs in VS samples derived from poor hearing patients belonged to miR 449a/b, miR 15/16–1, and hypoxamiR families. Functional analysis showed that the differentially expressed miRNAs regulate cellular pathways associated with hypoxia, adherence junction functions, and signaling pathways such as Hippo, FOXO, MAPK, and Wnt signaling pathway.ConclusionOur study identified a specific miRNA expression profile in VS tumor tissues that correlates with hearing impairment. These results suggest potential new molecular mechanisms related to hearing loss in the course of VS.Level of Evidence3 (cohort study) Laryngoscope, 134:3778–3785, 2024
Microbial Analysis in Chronic Rhinosinusitis Patients with Chronic Kidney Disease and End‐Stage Renal Disease
Authors: Lo Sheng‐Wei , Ding Meng‐Chang , Tsai Yao‐Te , Tsai Ming‐Shao , Liu Chia‐Yen , Hsu Cheng‐Ming , Yang Yao‐Hsu , Chang Geng‐He 
Published: March 2024

IntroductionThis study aimed to elucidate the bacterial profile of chronic rhinosinusitis (CRS) in patients with end‐stage renal disease (ESRD) and chronic kidney disease (CKD) compared with nonrenal patients, guiding antibiotic selection for clinicians.MethodsWe retrospectively analyzed 13,906 inpatients from the Chang Gung Research Database who underwent sinus surgery (2004–2018). Patients were categorized into ESRD‐CRS, CKD‐CRS, and non‐CKD‐CRS based on the estimated glomerular filtration rate. Bacterial cultures from surgical samples were classified as facultative anaerobes or aerobes (e.g., Klebsiella pneumoniae [KP], Pseudomonas aeruginosa [Ps.a]), anaerobes, and fungi and ranked by prevalence.ResultsData from 47 ESRD‐CRS, 230 CKD‐CRS, and 13,123 non‐CKD‐CRS patients were analyzed. In ESRD‐CRS, the predominant species were KP (31.6%), Ps.a (21.1%), and Coagulase‐negative Staphylococcus (CoNS, 15.8%). CKD‐CRS showed Staphylococcus epidermidis (27.7%), CoNS (20.5%), and Ps.a (20.5%). Non‐CKD‐CRS had Staphylococcus epidermidis (29.8%), CoNS (25.0%), and Staphylococcus aureus (15.5%). For anaerobes, ESRD‐CRS was dominated by Fusobacterium nucleatum (10.5%) and Peptostreptococcus micros (10.5%), whereas CKD‐CRS and non‐CKD‐CRS showed Propionibacterium acnes as a primary strain (14.5% and 28.7%, respectively).ConclusionFor CRS in ESRD, antibiotics targeting KP and Fusobacterium nucleatum are recommended. In CKD‐CRS, a focus on Staphylococcus epidermidis and Propionibacterium acnes is suggested.Level of Evidence4 Laryngoscope, 134:3499–3507, 2024
Vertical trophic structure and niche partitioning of gelatinous predators in a pelagic food web: Insights from stable isotopes of siphonophores
Authors: Hetherington Elizabeth D. , Close Hilary G. , Haddock Steven H. D. , Damian‐Serrano Alejandro , Dunn Casey W. , Wallsgrove Natalie J. , Doherty Shannon C. , Choy C. Anela 
Published: March 2024

AbstractGelatinous zooplankton are increasingly recognized as key components of pelagic ecosystems, and there have been many recent insights into their ecology and roles in food webs. To examine the trophic ecology of siphonophores (Cnidaria, Hydrozoa), we used bulk (carbon and nitrogen) and compound‐specific (nitrogen) isotope analysis of individual amino acids (CSIA‐AA). We collected samples of 15 siphonophore genera using blue‐water diving, midwater trawls, and remotely operated vehicles in the California Current Ecosystem, from 0 to 3000 m. We examined the basal resources supporting siphonophore nutrition by comparing their isotope values to those of contemporaneously collected sinking and suspended particles (0–500 m). Stable isotope values provided novel insights into siphonophore trophic ecology, indicating considerable niche overlap between calycophoran and physonect siphonophores. However, there were clear relationships between siphonophore trophic positions and phylogeny, and the highest siphonophore trophic positions were restricted to physonects. Bulk and source amino acid nitrogen isotope (δ15N) values of siphonophores and suspended particles all increased significantly with increasing collection depth. In contrast, siphonophore trophic positions did not increase with increasing collection depth. This suggests that microbially reworked, deep, suspended particles with higher δ15N values than surface particles, likely indirectly support deep‐pelagic siphonophores. Siphonophores feed upon a range of prey, from small crustaceans to fishes, and we show that their measured trophic positions reflect this trophic diversity, spanning 1.5 trophic levels (range 2.4–4.0). Further, we demonstrate that CSIA‐AA can elucidate the feeding ecology of gelatinous zooplankton and distinguish between nutritional resources across vertical habitats. These findings improve our understanding of the functional roles of gelatinous zooplankton and energy flow through pelagic food webs.