bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral mucosal ulceration in systemic lupus erythematosus
Authors: Urman Jeffrey D. , Lowenstein Mitchell B. , Abeles Micha , Weinstein Arthur 
Published: February 2007

AbstractIn 182 patients with systemic lupus erythematosus (SLE), oral mucosal ulceration occurred in 47 patients (26%), was usually painless (82%), and most often involved the hard palate (89%). Oral ulceration was associated with an increase in overall clinical activity, although this was not accompanied by significant changes in the levels or titers of C3, anti‐DNA antibodies, and antinuclear antibodies. Necrotizing vasculitis was not observed. Microscopic changes were similar to the skin lesions of SLE and immunoglobulin and complement were found in both the basement membrane and blood vessel walls.
Muscle disease in progressive systemic sclerosis. diagnostic and therapeutic considerations
Authors: Clements Philip J. , Furst Daniel E. , Campion David S. , Bohan Anthony , Harris Robert , Levy Joshua , Paulus Harold E. 
Published: February 2007

AbstractUpon careful examination, 23 of 24 patients with progressive systemic sclerosis (PSS) were found to have abnormalities of muscle. Nineteen patients presented a homogeneous pattern of muscle abnormalities, which untreated was associated with a stable course (“simple myopathy”). Three patients demonstrated inflammatory muscle disease indistinguishable from polymyositis while a fourth patient developed marked weakness associated with a generalized neuropathic process. Muscle enzymes, electromyogram, and muscle biopsy permitted distinction among the different muscle disorders, a distinction that could have prognostic and therapeutic importance.
Hand structure and function in an industrial setting.
Authors: Hadler Nortin M. , Gillings Dennis B. , Imbus Harold R. , Levitin Peter M. , Makuc Diane , Utsinger Peter D. , Yount William J. , Slusser Derwood , Moskovitz Nancy 
Published: February 2007

AbstractThe influence of patterns of usage on the structure and function of the hands was formally tested. Three groups of female textile workers, each employed in a distinct and defined, atraumatic, repetitive, stereotyped manual task for at least 20 years, were identified in a single rural mill. Replicate data were obtained for the following measures of structure and function: range of motion, a score for the degree of radiographic degenerative changes at each hand joint, malalignment at digital joints determined radiographically, and a quantitative measure of osteophyte formation. Significant and consistent differences in the right hand when compared to the left were detected. Furthermore, highly significant task‐related differences were demonstrated. These task‐related differences in the structure and function of the hands were consistent with the pattern of usage. Therefore these three patterns of usage influence hand structure and function in the population studied.
Thrombocytosis and platelet aggregates in the circulation of adjuvant arthritic rats
Authors: Görög Peter , Kovács Iren B. 
Published: February 2007

AbstractA marked increase in platelet count was observed in adjuvant‐induced polyarthritic rats. Elevation of platelet count was still significant 3 months after onset of disease. Increased number and larger size of platelets reflect an increase in the rate of platelet production. By means of the platelet‐count ratio technique, circulating platelet aggregates were demonstrated in rats with severe arthritis. Aspirin treatment prevented thrombocytosis and formation of platelet aggregates.
Lymphopenia In Systemic Lupus Erythematosus
Authors: Rivero Santiago J. , Díaz‐Jouanen Efraín , Alarcón‐Segovia Donato 
Published: February 2007

AbstractOne hundred fifty‐eight patients with active, untreated systemic lupus erythematosus (SLE) were studied from the time of diagnosis. Lymphopenia was present in 75%, and another 18% of these patients developed lymphopenia subsequent to disease reactivation. Lymphopenia of less than 1500 cells/m̈l occurred more frequently than any of the preliminary criteria for the classification of SLE, and it was the most prevalent initial laboratory abnormality. Lymphocyte counts were significantly lower in lupus than in the other connective tissue diseases except mixed connective tissue disease and polymyositis.
Immunoglobulin in Tophi and on the Surface of Monosodium Urate Crystals
Authors: Hasselbacher Peter , Schumacher H. Ralph 
Published: February 2007

AbstractBy means of immunohistologic techniques IgG, IgM, and to a lesser degree, IgA were found in the inter‐crystalline matrix of gouty tophi. Smaller amounts of IgG and IgM were inconstantly found in association with tissue deposits of calcium pyrophosphate. When a technique of immune agglutination was used, the affinity of all three major classes of immunoglobulin to the surface of monosodium urate (MSU) crystals was demonstrated. Immunoglobulin and fibrin were found on MSU aspirated from large tophi.
Non–Giant Cell Temporal Arteritis. Three Cases And a Review Of The Literature
Authors: Morgan G. James , Harris Edward D. 
Published: February 2007

AbstractWe report two cases of polyarteritis and one of hypersensitivity angiitis diagnosed by temporal artery biopsy. Autopsies showed no evidence of giant cell arteritis. A review of the English literature provides seven further autopsy cases of necrotizing vasculitis diagnosed by temporal artery biopsy. The term temporal arteritis includes many types of vasculitis, giant cell arteritis being one of them.
Prevalence of Rheumatic Diseases as Causes of Disability and Complaints by Ambulatory Patients
Authors: Reynolds Michael D. 
Published: February 2007

AbstractData from the National Health Survey reveal that musculoskeletal diseases are the most prevalent cause of chronic disability among the civilian, noninstitutionalized population. Because of the frequency of musculoskeletal injuries, rheumatic disorders are the second most common cause of acute disability. Problems referable to the musculoskeletal system constitute the second most frequent class of complaints presented by patients to office‐based physicians. Only respiratory and circulatory diagnoses are recorded more often by such physicians.
Effect of the anti‐estrogen, nafoxidine, on nzb/w autoimmune disease
Authors: Duvic Madeleine , Steinberg Alfred D. , Klassen Lynell W. 
Published: February 2007

AbstractTreatment of female NZB/W F1 mice with Nafoxidine, an anti‐estrogen, led to delayed manifestation of autoimmune features. Such treated mice had reduced anti‐DNA antibodies, reduced proteinuria, and improved survival. These results support the hypothesis that sex hormones play an important role in the expression of autoimmunity and suggest that estrogens may accelerate autoimmunity in NZB/W F1 mice.
Pathologic features of a familial arthropathy associated with congenital flexion contractures of fingers
Authors: Athreya Balu H. , Ralph Schumacher H. 
Published: February 2007

AbstractThree siblings with a recently recognized form of familial arthropathy were studied clinically and by light and electron microscopy of the synovium. On light microscopy, the synovium from all 3 children showed synovial hyperplasia, necrotic villi, deposition of eosinophilic and PAS‐positive material, and large numbers of multinucleated giant cells. Electron microscopy of the synovium in one patient revealed giant cells with profuse rough and smooth endoplasmic reticulum. Some phagocytic cells contained degenerated collagen in vacuoles or invaginations. There was granular and fibrinlike material on the synovial surface, but no amyloid. This symmetrical arthropathy now reported in three families appears to have characteristic histological appearance of synovium that allows its identification as distinct from other known joint diseases.
Light chain heterogeneity of 19s and 7s anti‐γ‐globulins in rheumatoid arthritis and subacute bacterial endocarditis
Authors: Carson Dennis A. , Lawrance Simon 
Published: February 2007

AbstractBoth 19S and 7S anti‐γ‐globulins in rheumatoid arthritis sera are enriched in kappa light chain bearing antibody molecules when compared to total 19S and 7S globulins from the same individuals. In patients with subacute bacterial endocarditis 19S anti‐γ‐globulins are also, to a degree, enriched in kappa light chains, whereas the 7S anti‐γ‐globulins have kappa to lambda light chain ratios indistinguishable from total 7S globulin.
Comparison of gold levels and distribution in guinea pig serum
Authors: Kamel H. , Brown D. H. , Ottaway J. M. , Smith W. E. , Cottney J. , Lewis A. J. 
Published: February 2007

AbstractSerum levels after oral administration of 30 mg/kg of sodium aurothiomalate (Myocrisin), triethylphosphine gold chloride, or triphenylphosphine gold chloride to guinea pigs indicated that all were orally absorbed. However, the serum gold level of triethylphosphine gold chloride was three to four times that of Myocrisin or triphenylphosphine gold chloride and was comparable with the serum level produced when the same dose of Myocrisin was injected intramuscularly. A comparative time‐course study between intramuscular administration of Myocrisin and oral administration of triethylphosphine gold chloride indicated that during the first 24 hours after intramuscular injection of Myocrisin, a large fraction of the gold was not protein‐bound, whereas all detectable gold in serum after oral administration of triethylphosphine gold chloride was protein‐bound. Gold levels in the separated protein fractions indicate that the γ‐globulin level after oral administration of triethylphosphine gold chloride is approximately three times higher after 24 hours than with intramuscular Myocrisin.
Age, sex, and race effects on mortality from systemic lupus erythematosus in the united states
Authors: Kaslow Richard A. , Masi Alfonse T. 
Published: February 2007

AbstractNationwide rates of death from systemic lupus erythematosus (SLE) were estimated from National Center for Health Statistics mortality data for 1968 to 1972 according to age, sex, and race. The overall rates for females, 6.3 per million person‐years (whites 5.2, blacks 14.8), were about four times that for males, 1.6 per million person‐years (whites 1.5, blacks 2.2). The overall rate for blacks, 8.8, was 2.6 times that for whites, 3.4. An earlier rise in age‐specific mortality rates for females than males produced higher age‐specific female‐to‐male sex ratios in the early adult years than in later years. Mortality generally increased with age in whites whereas the phenomenon of an accentuation and decline during the early and middle adult ages was seen in blacks, particularly females. Analysis of age‐, sex‐, race‐specific rates using one measure of synergistic interaction, S, revealed substantial synergy between the effects of sex and race on mortality during the childbearing ages (S = 3.2, 95% confidence interval = 2.3–4.4).
Autoimmune neutropenia in systemic lupus erythematosus
Authors: Starkebaum Gordon , Price Thomas H. , Lee Minako Y. , Arend William P. 
Published: February 2007

AbstractThe mechanism of granulocyte depletion in a patient with systemic lupus erythematosus and neutropenia was investigated. Neutrophil kinetic studies showed a shortened intravascular survival (t1/2 of 1.6 hours) in the face of an increased marrow neutrophil pool. IgG bound to the patient's neutrophils, measured by the Fab anti‐F(ab)2 assay, was nearly three times normal. The IgG neutrophil‐binding activity of the patient's serum was elevated in serial samples obtained over two years. In addition, his serum was able to opsonize normal neutrophils for ingestion by other neutrophils as detected by 14C‐1‐glucose oxidation. Enhanced IgG PMN‐binding activity was observed with sucrose density gradient fractions of the patient's serum containing either large complexes (19S or greater in size), intermediate complexes (between 7S and 19S), or monomeric IgG. Only the monomeric IgG fraction from the patient's serum, however, opsonized normal neutrophils for ingestion by other neutrophils. These results support the hypothesis that anti‐cell antibodies were responsible for the neutropenia in this patient by opsonizing neutrophils for ingestion by other phagocytic cells.
A subgroup of ankylosing spondylitis associated with hla‐b7 in american blacks
Authors: A. Khan Muhammad , Kushner Irving , E. Braun William 
Published: February 2007

AbstractIn a study of 34 American black patients with primary ankylosing spondylitis, 18 were found to be HLA‐B27‐negative. Of these, 10 possessed HLA‐B7 (55.6%) compared to 23.7% of 59 B27‐negative black controls (P < 0.025, relative risk = 4). On comparing these 10 B7‐positive patients (group I) with 16 B27‐positive black patients (group II), a difference in mean age at onset of disease was found: 33.6 years in group I and 22.2 years in group II (P < 0.005). In addition, a family history of ankylosing spondylitis was absent in group I patients but present in 6 patients in group II (P = 0.034). These findings indicate an association between HLA‐B7 and ankylosing spondylitis in American blacks and suggest that these patients who lack B27 but possess B7 represent a subgroup of patients with this disease.
The infectious etiology of rheumatoid arthritis.
Authors: Bennett J. Claude 
Published: February 2007

AbstractSeveral possible mechanisms of chronic inflammatory arthritis that might be initiated by infectious agents are discussed. Some recent information on mycoplasma infections, long‐term virus infections, and shed bacterial components provides the bases for new experimental approaches. Currently, evidence of involvement of mycoplasma or viral agents in rheumatoid arthritis is tenuous. Chronic peptidoglycan–immune‐complex formation is a consideration that has been discussed, but only recently pursued in depth. It may well be that experimental studies on the infectious etiology of rheumatoid arthritis will be revitalized through an appreciation of the bacterial antigen load in the gastrointestinal tract. The experimental vehicles for testing this possibility are available and should be directly applicable at the clinical level.
Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrysotherapy
Authors: Gottlieb Norman L. , Major James C. 
Published: February 2007

AbstractThe eyes of 11 patients with rheumatoid arthritis (RA) who received extended chrysotherapy (mean cumulative dose greater than 7 grams during a mean 6‐year period) were examined biomicroscopically. Minute reddish‐purple particles were seen in the cornea (corneal chrysiasis) in 5 and in the lens (lens chrysiasis) in 4 patients. Particulate deposits were absent in 11 other RA patients who had not received gold treatment. Seven crystalline lenses from 5 gold‐treated patients were removed surgically because of incidental cataract formation and analyzed for gold content using neutron activation analysis. Although the mean lens gold concentration was higher in these patients than in non–gold‐treated controls without RA (0.0073 m̈g/grams versus 0.001 m̈g/grams), the absolute gold level was markedly lower than that found in 25 diverse tissues analyzed previously. This finding is compatible with the absence of clinical gold‐related lens disease or visual impairment.
Marrow aplasia induced by colchicine. a case report
Authors: Liu Yong K. , Hymowitz Richard , Carroll Michael G. 
Published: February 2007

AbstractA 70 year old male developed marrow aplasia and pancytopenia after receiving 10 mg of colchicine intravenously over a period of 5 days for acute gouty arthritis. Despite a fatal outcome, evidence of recovery of hematopoiesis was observed in the bone marrow 3 days after the last dose of the drug. The pathogenetic mechanism by which colchicine induced marrow aplasia in this patient remains unclear.
Collagenase production by cultures containing multinucleated cells derived from synovial fibroblasts
Authors: Brinckerhoff Constance E. , Harris Edward D. 
Published: February 2007

AbstractMultinucleate cells are found frequently in rheumatoid synovium. In this study, polyethylene glycol was used to fuse rabbit synovial fibroblasts. Approximately 40% of the cells developed more than one nucleus in a 24 hour period, during which time cell membranes had increased permeability. In cultures containing multinucleate cells, 3H‐thymidine incorporation was depressed for 24 hours although 3H‐leucine incorporation into TCA precipitable material was unaffected; autoradiography showed that depression of 3H‐thymidine continued for at least 4 days. Collagenase production by cultures containing fused cells was increased more than 10‐fold over control cultures during a 28 day period.
Temporal arteriography. analysis of 21 cases and a review of the literature
Authors: Layfer Lawrence F. , Banner Barbara F. , Huckman Michael S. , Grainer Lorne S. , Golden Harvey E. 
Published: February 2007

AbstractTo define the role of temporal arteriography in the diagnosis of giant‐cell arteritis, the results of temporal arteriography in 21 patients who had temporal artery biopsies were reviewed. Abnormal angiography was found in all patients with biopsy‐proven giant‐cell arteritis, in some patients with polymyalgia rheumatica and normal biopsy, and in some patients with neither polymyalgia rheumatica nor giant‐cell arteritis. No pattern of angiographic abnormality typical for giant‐cell arteritis could be found. Results suggest temporal arteriography is a sensitive but nonspecific procedure in the diagnosis of giant‐cell arteritis and must be coupled with biopsy of angiographic abnormalities for confirmation of diagnosis.
Chrysotherapy. suppression of immunoglobulin synthesis
Authors: Lorber Arthur , Simon Timothy , Leeb John , Peter Alan , Wilcox Stuart 
Published: February 2007

AbstractForty‐four subjects with classic or definite rheumatoid arthritis who were on individualized chrysotherapy were observed for changes in serum protein electrophoresis, immunoglobulins, and circulating lymphocyte counts. By paired variate analysis, significant declines from pretreatment values were recorded for the following—electrophoretic protein fractions: gamma, alpha‐1, alpha‐2, (P < 0.05); immunoglobulins: IgM—53% (P < 0.001), IgG—37% (P < 0.01), IgA—34% (P < 0.001). Rheumatoid factor decreased in 29 of 39 subjects, 15 becoming seronegative (P < 0.001); circulating lymphocytes decreased by 27% (P < 0.001). The maximal suppressive effect on IgG and IgM was not achieved until the third and fourth years of therapy by sustained weekly administration of gold sodium thiomalate (one year cumulative dosage, mean 2106 mg, range 1065–2,885; ≥ 4 year cumulative dosage, mean 8747 mg, range 5,385–15, 160 mg). An immunosuppressive effect is suggested by these results.
Herpes zoster in patients with systemic lupus erythematosus
Authors: Moutsopoulos Haralampos M. , Gallagher John D. , Decker John L. , Steinberg Alfred D. 
Published: February 2007

AbstractIn the context of prospective trials of immunosuppressive drugs in systemic lupus erythematosus (SLE) nephritis, 83 patients were studied with regard to development of herpes zoster.Herpes zoster was found to occur with high frequency (21%) in patients with SLE nephritis treated with immunosuppressive agents. The course of herpes zoster was benign: no deaths occurred and only 2 of the 18 patients developed generalized disease, which resolved without sequelae. Specific antiviral therapy was not necessary and there appears to be no need to decrease immunosuppressive medications. Zoster occurred when the SLE was relatively inactive and did not exacerbate the SLE. No statistical difference in the incidence of zoster was found among the patient groups treated with different immunosuppressive regimens.
Relative reactivities of rheumatoid factors in serum and cells. evidence for a selective deficiency in serum rheumatoid factor
Authors: Robbins Dick L. , Moore Terry L. , Carson Dennis A. , Vaughan John H. 
Published: February 2007

AbstractInvestigations of rheumatoid factors by a hemolytic plaque forming cell assay of blood lymphocytes with sensitized sheep cells have suggested that the rheumatoid factors released from the cells have higher affinities for human IgG than do the rheumatoid factors measured in the patient's serum. This study reaffirms this observation and provides evidence that the reported differences are not artifacts of technique. The findings imply that rheumatoid factors of higher affinity for IgG than those of the serum are being released into the tissue fluids by lymphocytes and locally precipitated. Such rheumatoid factors may never reach the peripheral blood serum in detectable quantity or may do so only infrequently.
Hemochromatotic arthropathy mimicking rheumatoid arthritis. a case with subcutaneous nodules, tenosynovitis, and bursitis
Authors: Bensen William G. , Laskin Carl A. , Little Hugh A. , Fam Adel G. 
Published: February 2007

AbstractA 63‐year‐old man developed symmetrical polyarthritis, subcutaneous nodules at the elbows, olecranon bursitis, and recurrent tenosynovitis. He was later discovered to have idiopathic hemochromatosis. Staining of the subcutaneous nodule revealed iron deposits. These manifestations which are common to rheumatoid arthritis may be seen in hemochromatotic arthropathy.
Immunologic sex differences and the female predominance in systemic lupus erythematosus
Authors: Inman Robert D. 
Published: February 2007

AbstractThe female predominance in many rheumatic disorders, most notably systemic lupus erythematosus, suggests that immunologic sex differences may modify susceptibility to disease. Clinical and experimental data indicate heightened humoral immunity and depressed cellular immunity in females compared with males. These differences appear to be mediated by sex hormones.
Reactivities of systemic lupus erythematosus sera with cellular and virus antigen preparations
Authors: Pincus Theodore , Steinberg Alfred D. , Blacklow Neil R. , Decker John L. 
Published: February 2007

AbstractSera of patients with systemic lupus erythematosus (SLE) showed significantly higher complement fixation reactivities with 8 of 10 virus antigen preparations compared to sera of normal subjects, including virus workers, confirming earlier observations. However, one‐third of SLE sera were also reactive with cellular antigens, prepared in a manner identical to viral antigens, but from cells not infected with virus. By contrast, only one of 49 normal sera showed reactivity with one of nine cellular antigens, at a minimal titer. Apparently heightened reactivities of SLE sera with virus antigens could be explained in many instances on the basis of reactions with cellular antigens. Serum reactivities with nonviral tissue antigens in SLE must be considered in interpretation of immunologic studies related to viruses and SLE.
Involvement of prostaglandins from rheumatoid synovium in inhibition of articular cartilage metabolism
Authors: Lippiello L. , Yamamoto K. , Robinson D. , Mankin H. J. 
Published: February 2007

AbstractShort term incubations of articular cartilage in media from cultures of rheumatoid synovial tissue result in marked inhibition of 3H‐glycine and Na235SO4 incorporation into trichloroacetic acid (TCA) insoluble macro‐molecules by the cartilage segments with little effect on degradation of prelabeled cartilage matrix. This inhibition is time dependent and not observed in cartilage segments incubated in media derived from rheumatoid synovia cultured in the presence of indomethacin (a specific inhibitor of prostaglandin synthesis). In addition, no indomethacin‐sensitive cartilage inhibitory activity was detectable in media from cultures of normal synovia. The ether solubility of the majority of the inhibitory activity and the indomethacin sensitivity suggest that the inhibitor(s) are prostaglandins.The significance of prostaglandin‐induced cartilage inhibitory activity derived from rheumatoid synovial tissue remains speculative. However, these data suggest that prostaglandins may play a substantial role in the development of cartilaginous lesions in inflammatory arthritis in which elevated prostaglandin levels are commonly found in the synovial fluid.