bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Macrophage Inhibitory Cytokine-1 Concentrations Correlate with the Presence of Prostate Cancer Bone Metastases
Authors: Selander Katri S. , Brown David A. , Sequeiros Guillermo Blanco , Hunter Mark , Desmond Renee , Parpala Teija , Risteli Juha , Breit Samuel N. , Jukkola-Vuorinen Arja 
Published: March 2007

Abstract
Macrophage-inhibitory cytokine-1 (MIC-1) is a divergent member of the transforming growth factor β superfamily. It is up-regulated by nonsteroidal anti-inflammatory drugs and is highly expressed in human prostate cancer leading to high serum MIC-1 concentrations with advanced disease. A role for MIC-1 has been implicated in the process of early bone formation, suggesting that it may also mediate sclerosis at the site of prostate cancer bone metastases. Consequently, the aim of this study was to retrospectively determine the relationship of serum MIC-1 concentration and other markers related to current and future prostate cancer bone metastasis in a cohort of 159 patients with prostate cancer. Serum markers included cross-linked carboxy-terminal telopeptide of type I collagen, prostate-specific antigen, and amino-terminal propeptide of type I procollagen (PINP). The mean values of all the biomarkers studied were significantly higher in patients with baseline bone metastases (BM+, n = 35), when compared with those without bone metastases (BM−, n = 124). In a multivariate logistic model, both MIC-1 and PINP independently predicted the presence of baseline bone metastasis. Based on receiver operator curve analysis, the best predictor for the presence of baseline bone metastasis was MIC-1, which was significantly better than carboxy-terminal telopeptide of type I collagen, prostate-specific antigen, and PINP. Patients who experienced bone relapse had significantly higher levels of baseline MIC-1 compared with patients who did not (1476.7 versus 988.4; P = 0.03). Current use of acetylsalicylic acid did not influence serum MIC-1 levels in this cohort. Although requiring validation prospectively, these results suggest that serum MIC-1 determination may be a valuable tool for the diagnosis of current and future bone metastases in patients with prostate cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(3):532–7)
The Association between the Anti-inflammatory Protein CC10 and Smoking Status among Participants in a Chemoprevention Trial
Authors: Chen Jiping , Lam Stephen , Pilon Aprile , McWilliams Annette , Melby James , Szabo Eva 
Published: March 2007

AbstractCC10, the secretory product of bronchiolar Clara cells, is infrequently expressed in non–small cell lung cancer (NSCLC), and its overexpression in NSCLC cell lines results in a less malignant phenotype. CC10 levels in bronchoalveolar lavage fluid (BAL) and serum are significantly lower in current smokers than healthy nonsmokers, but the effect of long-term smoking cessation on CC10 is unknown. We measured CC10 in baseline BAL and plasma collected from current (n = 81) and former (n = 23) smokers participating in a chemoprevention trial. Former smokers had significantly higher plasma CC10 levels compared with current smokers [mean, 62.1 ng/mL (95% CI, 43.0-81.2); range, 23.0-175.0 ng/mL for former smokers; and mean, 37.1 ng/mL (95% CI, 29.8-44.4); range, 5.0-171.0 ng/mL for current smokers; P &lt; 0.001]. BAL CC10 levels also trended in the same direction. A significant positive correlation was found between CC10 plasma and BAL levels. After adjustment for age, sex, and pack-years of cigarette consumption, former smokers had 1.70 (95% CI, 1.23-2.36) times higher plasma CC10 levels than current smokers (P &lt; 0.01), whereas former smokers also had nonsignificantly higher baseline BAL CC10 levels compared with current smokers [adjusted mean ratio (95% CI), 1.60 (0.92-2.80), P = 0.094 and 1.35 (0.86-2.10), P = 0.193 for the absolute and normalized BAL CC10, respectively]. These results show that sustained smoking cessation is associated with higher plasma CC10 levels, suggesting that at least some of the damage associated with tobacco smoke may be repaired by long-term smoking cessation. (Cancer Epidemiol Biomarkers Prev 2007;16(3):577–83)
Obesity, Diet and Risk of Non-Hodgkin Lymphoma
Authors: Skibola Christine F. 
Published: March 2007

AbstractNon-Hodgkin lymphoma (NHL) represents a group of heterogeneous diseases that significantly vary in their causes, molecular profiles, and natural progression. In 2007, there will be ∼59,000 newly diagnosed NHL cases in the United States and over 300,000 cases worldwide. Although new therapeutic regimens are minimizing the number of deaths related to NHL, causes for the majority of lymphomas remain undetermined. Recent studies suggest that dietary factors may contribute to the rising rates of NHL. This review will summarize epidemiologic reports that have studied the relationship between obesity, physical activity, and diet and risk of NHL. Based on a number of case-control and prospective cohort studies, overweight/obesity probably increases the risk of NHL, whereas moderate physical activity may reduce risk. Several studies support an inverse association between intakes of vegetables and NHL risk, particularly for the consumption of cruciferous vegetables. This may relate to the induction of apoptosis and growth arrest in preneoplastic and neoplastic cells, two important actions of isothiocyanates found in cruciferous vegetables. Studies also suggest that fish intake may be inversely associated with risk of NHL, although findings have not been entirely consistent. This may relate to the high organochlorine content in some fish that could override a protective effect. High consumption of fats, meat, and dairy products also may increase lymphoma risk. The accumulated scientific evidence concerning the associations between obesity, diet, and NHL suggests several identified modifiable risk factors that might be recommended to decrease lymphoma risk. (Cancer Epidemiol Biomarkers Prev 2007;16(3):392–5)
Role of Protease Activated Receptor 1 and 2 Signaling in Hypoxia-Induced Angiogenesis
Authors: Uusitalo-Jarvinen Hannele , Kurokawa Toru , Mueller Barbara M. , Andrade-Gordon Patricia , Friedlander Martin , Ruf Wolfram 
Published: March 2007

Objective—Tissue factor (TF) initiates coagulation and indirectly triggers thrombin-dependent protease activated receptor (PAR) signaling. The TF–VIIa complex also directly cleaves PAR2 and promotes angiogenesis in vitro in TF cytoplasmic domain-deleted (TFδCT) mice. Here we address the effect of PAR1 and PAR2 deficiency on angiogenesis in vivo.Methods and Results—In hypoxia-driven angiogenesis of oxygen induced retinopathy (OIR), wild-type, PAR1−/−, PAR2−/−, and TFδCTmice showed a comparable regression of the superficial vascular plexus during the initial exposure of mice to hyperoxia. However, TFδCTmice revascularized areas of central vaso-obliteration significantly faster than wild-type animals. Pharmacological inhibition of the TF–VIIa complex, but not of Xa, and blockade of tyrosine kinase receptor pathways with Gleevec reversed accelerated angiogenesis of TFδCTmice to revascularization rates observed in wild-type mice. Genetic deletion of PAR2, but not of PAR1, abolished enhanced revascularization of TFδCTmice. PAR1 knock-out animals were indistinguishable from wild-type mice in the model of retinal neoangiogenesis and angiogenesis-dependent subcutaneous tumor growth was unaltered in PAR1- and PAR2-deficient animals.Conclusion—Loss of the TF cytoplasmic domain results in accelerated hypoxia-induced angiogenesis mediated by TF–VIIa signaling. PAR2 signaling is sufficient for this proangiogenic effect without apparent contributions of mouse host cell PAR1.
Students—A Marginal Elite in Politics
Authors: Pinner Frank A. 
Published: March 2007

Student activism has rarely been examined in political perspective. Most of the existing literature treats it as a form of deviancy which must be explained as a special tendency of students to respond, in an unorthodox manner, to social, psychological, and cultural disturbances. Such formulations generally fail to account adequately for levels of activism, let alone the political positions—left or right, nationalistic or internationalist—which students espouse. This paper represents an attempt to lay the foundations for a political theory of student activism. It points out the affinities between students and other "marginal elites," the military and clerical professions, which tend to play indepen dent political roles at times of crisis. Most political alliances involving student movements are ephemeral because students lack effective means of coercion, such as armaments and religious sanctions. And being the weaker partners in any alliance, students tend to be deprived of most of the fruits of victory, or become an easy target of repression following defeat. They then move into ideo logical opposition to their former coalition partners. The paper illustrates these shifts in coalition patterns and ideo logical positions by tracing the historical changes in German student movements from the period of the Napoleonic wars to the present.
The Genealogy of Avenging Spirits
Authors: Umehara Takeshi 
Published: March 2007

I have given this essay the title: “The Genealogy of Avenging Spirits” after Nietzsche's treatise: “The Genealogy of Morals” (Zur Genealogie der Moral). In this book Nietzsche clarifies the origins and essence of Christian morality which constitutes the basis of European civilization. In a similar fashion I shall endeavor to point out the origins and essence of the concept of avenging spirits which seems to me to form the basis of Japanese civilization.It may seem strange to talk about a concept of avenging spirits. Nevertheless Norinaga Motoori considered mono-noawaré (the melancholy quality of things) the essence of Japanese culture; Daisetsu Suzuki, who was influenced by Zen, related its essence to a conception of Nothingness; and Ruth Benedict related it to the concept of shame as opposed to that of crime. I do not feel that these different opinions which have preceded mine are erroneous, for they undoubtedly capture certain aspects of our culture; however I would venture to say that it is more profoundly influenced by the concept of avenging spirits.
Productive Forces and Subjectivity; Socialism as Marx Saw It
Authors: Henry Michel 
Published: March 2007

… The ultimate contradiction of capitalism—in the words of Marx—can be understood and should be described as follows: capitalism is the value-system, its development and its maintenance (money being the external value); value is produced exclusively by work done by men and women; the fate of capital is thus the fate of this work—the subjective praxis of the individual. Inasmuch as the real process of production includes within it the accomplishment of this praxis, it is precisely the same thing as a process of value-formation, a process of valorization. *From here stems the first moment of Marx's problematics: his analysis of capital as it effectively exists; in other words, his analysis of the process of its formation, which in turn leads to the analysis of the real process of production and the revelation, in this process, of the element that produces value, namely, this subjective praxis. Economic analysis, therefore, is nothing more than the analysis of the effects of the real component parts of the process; the composition of capital into value refers, inasmuch as it is an organic composition, to its technical composition and this is where its whole explanation lies.
Linguistic Politics During the French Revolution
Authors: Lartichaux Jean-Yves 
Published: March 2007

Rarely is the problem of the diversity of languages taken into account whenever population groups are formed into States. When the problem does come up, it is later, in a primarily political context which tries to find political solutions, such as we may presently see them in Canada or in Belgium for instance. These solutions are few and they deal with situations that may contain a host of nuances.Certain countries have chosen a vehicular language while keeping their local languages: the common language in the USSR is the language of one of its republics. In Senegal it is French, which is of a totally foreign origin but has the advantage of avoiding the rivalry existing among the native languages, and it also has a place within the international community. Other countries have accepted as official languages the different languages spoken within its borders. Thus Switzerland is officially tri-lingual (French, German, Italian), giving legal status to what somewhere else may simply be an accepted fact. Many Alsatians speak three languages (Alsatian, French, German). As far as it concerns countries with a strong linguistic heterogeneity, whether it be their history or their size making for a centralizing policy, they have adopted, with the resulting neglect of all others, the language or the idiom of the region which was politically or culturally the dominant one at the time of their unification. Pekinese has been extended to all of China, Florentine to Italy, Hindi to India. Some original combinations can be found: in Israel Jewish immigrants who came from more than seventy different countries, have again taken up the nation's old cultural and religious language, which had been out of use for two thousand years, and have placed it on equal footing with Arabic spoken by the local population, while English is being used for international relations.
The Truth of Imagination
Authors: Koestler Arthur 
Published: March 2007

There is an obscure passage in a letter from Keats to Benjamin Bailey, written in 1817, which says:
I am certain of nothing but of the holiness of the Heart's affections and the truth of Imagination...This does not seem to make much sense. Nor does it help much to find an echo of that passage in the famous last lines of the Ode on a Grecian Urn, written two years later:
Beauty is truth, truth beauty — that is all Ye know on earth, and all ye need to know.
Is a Scientific Approach To the Eschatological Problem Possible?
Authors: Nalimov Vassili V. 
Published: March 2007

“For there shall be days when you will say: Blessed is the womb which has not conceived, and those breasts which have not given suck.”The Apocryphal Gospel of Thomas (1)“ Oh man! why is the world becoming so narrow for you? You want to possess it alone; but if you had possessed it, it would not have been spacious enough for you:Ah! this is the pride of the devil who has fallen from heaven into hell.”
The Plague, Melancholy and the Devil
Authors: Azouvi François 
Published: March 2007

The advent of science brought about a radical division between the means of expression it made possible and the one it disavowed: in the centuries preceding its establishment such a break was not possible, even though it was often desired.Medical treatises of the Renaissance that analyze the plague and melancholy used categories that were not different from those used by theologians (and sometimes doctors) as far as their reference to the Devil was concerned. Since it is no less a question of the imagination in one case than in the other, we can try to associate these three “objects”-three figures of misfortune-and treat them as though they belonged to the same level of expression. Such a decision is not at all arbitrary; it proceeds, completely a posteriori, from the observation of a noticeable proximity between them, aside from their diversity: it is as though they offered variations on a certain number of themes, variations requested by a logic of the imaginary that we shall try to elucidate here by showing the several categories that serve as a point of departure for the functioning of that logic.
Children of Impurity
Authors: Makarius Laura 
Published: March 2007

Mythologies generally devote much attention to the birth of heroes and gods whose coming into the world is described as particular. Our first examples come from Greek mythology.The Furies, goddesses of vengeance, were born of the blood of Uranus who had been castrated by his son Cronos. Athena sprang, completely armed, from the head of Zeus which Prometheus had struck with an axe, an act sometimes attributed to Hephaistos. The Centaurs came from a union of Ixion with a cloud to which Zeus had given the appearance of Hera with whom he was in love. Adonis came into the world from a myrrh tree (Smyrna in Greek ) which opened magically to give him birth. Ten years earlier a woman named Smyrna (myrrh) had committed incest with her father, Theios, without his realizing it; when he discovered the fact, he changed her into the tree known by that name. Bacchus was drawn out, a six months old fetus, from the body of his mother by Zeus. The body was lying in coals lit by the lightning and thunder accompanying the god's chariot as he came to visit Semele. Terrified at the sound of nature's fury, she had died of shock. Zeus sewed the fetus in his thigh and, when the time came, gave birth to Dionysius.
Creation as Transformation
Authors: Lath Mukund 
Published: March 2007

(A notion of imagination as Creative Transformation envisaged by certain ancient Indian literary critics and its application in the field of music.)The idea of creative imagination naturally suggests artistic activity. Activity such as that of the writer, the painter, the sculptor, the musician, the dancer, the architect and the like. This, we generally think, is the homeground of creative imagination, though, as has been justly pointed out, every human endeavour, whether thought or action, presupposes it, or, at least, needs it in order to be significant. The writer comes first on my list because we who deal in words tend to think of literature before any other art, as is amply borne out by our proceedings here. But I have another, a more important reason for listing him first. Reflections over the writer's art, that is, literature, has a longer history and a greater depth of critical self-awareness in India than with respect to any other art, a fact which is perhaps true of most cultures.
The Shaman and the Ghosts of Unnatural Death: On the Efficacy of a Ritual
Authors: Michailovsky Boyd , Sagant Philippe 
Published: March 2007

In the Himalayan region, and even beyond it, odd behavior, illnesses, and especially sudden or accidental deaths, are attributed to the actions of the dead who have come back to torment the living.Among the Limbu tribesmen of eastern Nepal, these attacks take many different forms. The symptoms have very little in common from illness to illness. The eyes of infants roll back into their heads; they refuse to take the breast and die after only several months of life (they are called sa-sik). Women – as well as men – remain infertile, and are subject to bouts of confusion and temporary madness. Pregnancies often come to bad endings: there are spontaneous abortions, death in childbirth (sugup), an inability to produce milk. Men complain of stomach aches, tremendous headaches, vertigo, and various other troubles: they too are stricken with temporary madness, with loss of consciousness, and with inexplicable terrors that lead to fatal accidents or that even drive the victim, in a fit of rage, to murder or suicide (sogha). People of both sexes and all ages are affected. At home the family chickens often die suddenly and pigs choke to death.
Seoul, the Widow, and the Mudang: Transformations of Urban Korean Shamanism
Authors: Guillemoz Alexandre 
Published: March 2007

Does Seoul, a city of eight million inhabitants, one of the planet's ten megalopolises, still have shamans? Can there be a place for shamanism in a country like South Korea, which is striving to be modern? Can shamanism survive at all in a country where the successes of Christianity have been celebrated by Westerners? Can it adapt itself to religious pluralism? What is shamanism's role in the urban setting? How does the fast pace of urban life affect its rituals? How is shamanism presented in the mass media? Is it beginning to emerge from the centuries-long ostracism imposed on it by official ideologies?These questions will be explored in this article on the basis of data gathered on-site in the city of Seoul between the years 1982 and 1991. We will attempt not only to highlight several important facts but to grasp the overall process of transformation that the city is imposing on shamans and shamanism.
The Role and Functions of Contemporary Shamans in Southeast Asia
Authors: Heinze Ruth-Inge 
Published: March 2007

The meaning of the word shaman (of Tungus origin) has become obscured by numerous, increasingly different interpretations. The term has also been applied to practitioners who live outside Siberia, and are actually called by different names in their respective countries: bomoh in Malaysia, ma khi in Thailand, and tany-di in Singapore.Because I did not want to rely on secondary sources, I went to Southeast Asia to find contemporary shamans. Having started my research in 1960 I was able to witness, over a thirty-one year period (during visits lasting from several months to a year), the continuation of shamanic traditions among different groups living in multiethnic and multi-religious societies. What struck me most was the emergence of new shamans in urban centers like Singapore and Bangkok.
America - Europe: In the Mirror of Otherness
Authors: Montiel Edgar 
Published: March 2007

Vasco de QuirogaIt was precisely when printing became popular in Europe - which, for the first time in history, permitted the conservation and mass diffusion of ancient Greek, Arab, and Latin writings, a fact that signalled the beginning of the Renaissance - that the Letters of Amerigo Vespucci first appeared. These letters, like a revelation, speak of a novus mundus, a new world of unknown flora, fauna, and men, that contradicts the findings of Ptolemy‘s eminent Cosmography (published in 1478, in Rome), Theophrastus's History of Plants (published in 1498, in Venice), and the hallowed treatises of Aristotle, which were then in fashion.
The Man-Fauna Relationship in Mesoamerica Before and After the Europeans
Authors: Valadez Azúa M. en C. Raúl 
Published: March 2007

The year 1992 is a year for reflection, because whether or not the quincentenary celebration of the arrival of the Europeans to this continent seems justified, one cannot escape thinking about the impact of this event on our land.As archeology is my area of study, my reflections are directed toward the changes that came about in the relationship between man and animals after 1492, specifically toward what occurred in Mexico once the Spaniards established themselves in this territory.