bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYSTIC FIBROSIS IN DENMARK IN THE PERIOD 1945‐1981 EVALUATION OF CENTRALIZED TREATMENT
Authors: NIELSEN OLE HAAGEN , SCHIØTZ PETER OLUF 
Published: January 2008

Nielsen, O. H. and Schiøtz, P. O. (Paediatric Department TG, Rigshospitalet, Copenhagen, Denmark). Cystic fibrosis in Denmark in the period 1945‐1981. Acta Paediatr Scand 1982; suppl 301: 107‐119. — The present study gives a re‐evaluation of the course of the prognosis for cystic fibrosis (CF) in Denmark in the period January 1, 1945 — September 15, 1981. A total of 490 patients fulfilled the criteria of entry.Despite a rather constant annual incidence, the number of surviving CF patients is highly increasing: thus 31 patients were alive as on December 31, 1960, 119 as on December 31, 1970, and 223 as on December 31, 1980. The survival was further evaluated using the decrement method, where the patients are entered by time of birth or time of diagnosis, and the Warwick & Monson method, where the patients are entered by time of diagnosis. It applies to both methods that the underlying patient populations did not include patients with meconium ileus and patients with a retrospective or autopsy diagnosis. The probability of reaching the age of 10 years was 52% for CF patients treated exclusively in departments other than the CF centre as compared to 84% for the CF centre patients.We conclude that the centralized treatment should be preserved for a so relatively uncommon disease as CF, both because our survival curves demonstrated the prognosis to be by far the better in the patients treated at the national CF centre and because centralized treatment alone can offer appropriate research conditions.
I. Extra Early Physical Contact and Aspects of the Early Mother‐Infant Relationship
Authors: TAYLOR P. M. , TAYLOR F. H. , CAMPBELL S. B. , MALONI J. A. , CANNON M. 
Published: January 2008

ABSTRACT. We tested the hypothesis that extra early physical contact between mother and infant enhances aspects of their early relationship. Healthy, middle‐class mothers and their healthy, firstborn, singleton infants delivered vaginally at full‐term were randomly assigned to receive either regular contact (RC; N=39) or extra early physical contact (EC; N=39) following delivery. RC infants remained in cribs beside their mothers’beds, while EC infants and mothers had a mean of 46 min of physical contact in the recovery room.There was no difference between EC and RC subjects for the following outcome measures: amount of time mothers chose to have infants with them during the postpartum hospital stay; quality of mother‐infant interaction at two days and one month; concern mothers expressed for the infant at one month; mothers’perception of their postpartum adjustment; mothers’perception of the infant at two days and one month, and of the infant's temperament at eight months; and extent of mothers’assisting with and soothing the child during a physical examination at 13 months. EC children cried significantly less during the examination at 13 months. These findings do not support the hypothesis that extra early physical contact between mother and infant enhances their relationship.
Incidence of Cystic Fibrosis in Ethnic Italians and Greeks and in Australians of Predominantly British Origin
Authors: ALLAN JEAN L. , PHELAN P. D. 
Published: January 2008

ABSTRACTThe incidence of cystic fibrosis among the Australian born children of parents born in Italy was 1: 3 625 live births and among Australian born children of parents born in Greece 1: 3726. These incidences were significantly lower than the incidence for cystic fibrosis of 1: 2021 in children born to Australian born parents, about 90% of whom have ancestors born in the British Isles. The figures suggest there are significant variations in the incidence of cystic fibrosis in different European populations.
Long‐term Treatment with Corticosteroids/ACTH in Asthmatic Children
Authors: OBERGER E. , THORÉN M. , ENGSTRÖM I. 
Published: January 2008

ABSTRACTS Hypothalamic‐pituitary‐adrenal (HPA) function was studied in 23 children with severe bronchial asthma during and after long‐term treatment with prednisolone and/or ACTH1‐24 (depot tetracosactrin) by means of ACTH stimulation test and insulin tolerance test. In the 14 children primarily treated with depot tetracosactrin, the Cortisol levels in insulin tests were within normal limits both during and after treatment. An enhanced response to ACTH stimulation was found during the treatment period. During treatment with prednisolone a marked impairment of the adrenocortical function was found, with low basal plasma Cortisol levels and subnormal response to ACTH stimulation, more marked the lower the age at the start of treatment and the higher the dose per kg body weight. After substitution with depot tetracosactrin the HPA‐function was restituted, with plasma Cortisol levels within normal limits. Growth hormone levels after insulin induced hypoglycemia were ±7 ng/ml during and after treatment with depot tetracosactrin. As long‐term treatment with depot tetracosactrin has little side‐effects in terms of suppression of the HPA‐axis it is a useful alternative to oral prednisolone in severe asthma in children.
Knemometry as a Predictor of Response to Somatrem in Turner's Syndrome
Authors: WALES J. K. H. , MILNER R. D. G. 
Published: January 2008

ABSTRACT.Wales, J. K. H. and Milner, R. D. G. (Department of Paediatrics, University of Sheffield, Sheffield, UK). Knemometry as a predictor of response to somatrem in Turner's syndrome. Acta Paediatr Scand [Suppl] 337:37, 1987.The response of 13 children with Turner's syndrome to somatrem, 2 IU/day, has been determined for a 4‐week period of treatment using knemometric measurements, and compared to 6 months of treatment assessed by conventional auxology. In this small series, knemometry was able to predict those children in whom hGH therapy was not beneficial.
An Attempt to Assess the Replacement Dose of Human Growth Hormone in the Treatment of Growth Hormone Deficient Children
Authors: HIBI ITSURO , TANAKA TOSHIAKI , YANO HISAKO , UMEZAWA SACHIKO , KAGAWA JIRO , TANAE AYAKO , ISHIKAWA EIJI 
Published: January 2008

ABSTRACT.Hibi, I., Tanaka, T., Yano, H., Umezawa, S., Kagawa, J., Tanae, A. and Ishikawa, E. (National Children's Medical Research Center, Tokyo, the National Children's Hospital, Tokyo and the Department of Biochemistry, Miyazaki Medical College, Miyazaki, Japan). Acta Paediatr Scand [Suppl] 337:87, 1987.In 25 patients with hGH deficiency, who had been treated long‐term with hGH, the mode of hGH administration was switched from the conventional method (0.3–0.5 IU/kg/week, in two or three divided doses, intramuscularly) to daily subcutaneous injection at 1900–2100 hours with a dose of 0.46 ± 0.07 IU/kg/week (equivalent to 14.7 ± 2.0 IU/m2/week). After 1–3 months of this new mode of hGH administration, blood and urine were sampled at 0900 hours after overnight fasting. Blood glucose, plasma insulin, plasma IGF‐1 and plasma total IGF (after extraction) were analysed in blood samples. IGF‐1 and hGH were measured in urine samples. These measurements indicated that the dose studied was close to a replacement one, but might be slightly higher than the exact replacement dose.
VERY LOW BIRTH WEIGHT AND “DISSOCIATION OF MATURATION”: THE HAZARDS OF THE SENSORI‐MOTOR DEVELOPMENT
Authors: RAEYMAECKER DIRK MJ DE 
Published: January 2008

ABSTRACT:“Very low birth weight” and “Dissociation of Maturation” are two conditions with great impact on the sensor motor development. Data from our own research into the development of VLBW infants, clinical experience and insight, taken from the scientific literature, are the starting‐point for intellectual reflex ion on the significance of motor development for the sense of competence, growing autonomy, vigor and vitality. Moreover, the muscle tone of the infant has a profound impact on the mother‐infant relationship: especially the holding function of the mother and the playful togetherness between baby and care‐giver.“Anticipatory guidance” for mother and infants, by professionals, should be based on firm knowledge of neuromotor growth. “Prone progression”, truncal balance and upright posture are of the utmost importance even for psychological individuation.
Cow's Milk Allergy in the First Year of Life An Italian Collaborative Study Working Group on Cow's Milk Protein Allergy—Italian Working Group for Pediatric Gastroenterology of the Italian Society of Pediatrics
Authors: Ventura A. , Greco L. , Balli F. , Barbera C. , Bernini G. C. , Bertolani P. , Bianchi C. , Capano G. , Cardi E. , Castro M. , Cucchiara A. , D'Adamo G. , Filippo P. De , Manzini A. De , Seta L. De , Ferrario E. , Gentile T. , Iacono G. , Lucarelli S. , Papadatau B. , Parente C. , Prampolini L. , Roggero P. , Scotta M. S. , Tedeschi A. , Viola F. 
Published: January 2008

ABSTRACTThe diagnosis of Cow's Milk Protein Allergy was considered in 303 infants aged less than 1 year, who presented with one or more of the following symptoms: acute reaction related to cow's milk proteins (CMP) ingestion, severe colics, persisting vomiting, protracted diarrhea with or without blood and mucus, failure to thrive, eczema, respiratory symptoms, such as chronic rhinitis and wheezing. A diagnosis of CMPA was confirmed in 148 cases (60%): 125 relapsed on milk challenge, 23 were not challenged because of acute reactions at onset, presence of specific IgE (RAST and prick), and improvement on milk free diet. Familial atopy, familial history of CMPA and previous acute gastroenteritis were significantly more frequent in cases than in 191 age matched controls. Breast feeding was not more common or of longer duration in controls, compared to cases. Mean IgE serum levels were higher (46.3 U/ml) in cases than in controls (17 U/ml), while specific Cow's Milk Protein IgE were found in 71/148 cases (48%). 15 infants entered the study while on breast milk, because of the confirmed relation between their symptoms and CMP on the maternal diet. These infants had a higher prevalence of IgE mediated problems. All cases improved on a milk free diet but in 26 (17.8%) a further modification of the diet was required after the first prescription. Milk challenge was monitored by simple laboratory tests: all cases who had symptoms on challenge showed at least one test modification. Six infants, with no history of acute reaction, showed severe self‐limited clinical symptoms at challenge.
Effect of Recombinant Human Growth Hormone Therapy on Bone and Clinical Parameters in Girls with Turner's Syndrome
Authors: FERRANDEZ A. , MAYAYO E. , ARNAL J.M. , GARCIA C. , BURUEL C. , LASARTE J.J. , ANTON R. , PUYUELO P. 
Published: January 2008

ABSTRACTFerrández, A., Mayayo, E., Arnal, J.M., Garcia, C., Buduel, C., Lasarte, J.J., Anton, R., hyuelo P., and The Spanish Collaborative Group (Endocrine Unit, Children's Hospital, Miguel Servet, Zaragoza, Spain). Effect of recombinant human growth hormone therapy on bone and clinical parameters in girls with Turner's syndrome. Acta Paediatr Scand [Suppl] 356: 87, 1989.Forty‐eight girls with Turner's syndrome were assigned to one of three treatments; recombinant human growth hormone (rhGH) alone, rhGH plus oxandrolone, and rhGH plus ethinyloestradiol. Treatment with rhGH alone or in combination with oxandrolone induced catch‐up growth. Older girls treated with rhGH plus ethinyloestradiol showed less marked improvement. The gain in height was associated with a gain in bone diameter and cortical thickness (reflecting increased bone mass). There was a rapid loss of subcutaneous fat. These effects of growth hormone are similar to those observed in patients with growth hormone deficiency.
What More Can Be Done for Girls and Women with Turner's Syndrome and Their Parents?
Authors: NIELSEN J. 
Published: January 2008

ABSTRACTNielsen, J. (Cytogenetic Laboratory, Aarhus Psychiatric Hospital, Risskov, Denmark). What more can be done for girls and women with Turner's syndrome and their parents? Acta Paediatr Scand [Suppl] 356: 93, 1989.More should be done for Turner's girls/women and their parents. There is a need for early diagnosis, provision of information to Turner's parents, girls and women, provision of a support system in the form of Turner's contact groups, relevant treatment of all Turner's related disorders and problems at the appropriate age. More information is needed, including information given by physicians and Turner's women in journals, radio and television. This has been happening in Denmark during recent years. Turner's contact groups should be available in all countries, and all Turner's girls and women and their parents should be encouraged to join such groups. More research should be undertaken concerning growth, growth stimulating treatment, oestrogen treatment andin vitrofertilization in Turner's syndrome; more social‐psychological studies are also needed.
Socio‐economic Variables and Pregnancy Outcome Birthweight in Singletons
Authors: ERICSON A. , ERIKSSON M. , KÄLLÉN B. , ZETTERSTRÖM R. 
Published: January 2008

ABSTRACTEricson, A., Eriksson, M., Källén, B. and Zetterström, R. (The National Board of Health and Social Welfare, Department of Paediatrics, St. Göran's Hospital, Stockholm, and Department of Embryology, Lund, Sweden). Socio‐economic variables and pregnancy outcome. Birthweight in singletons. Acta Paediatr Scand Suppl 360: 48, 1989.The effect of various social indicators on birthweight in singletons was studied in Sweden with the use of a medical birth registry to which census information was linked. Two years were studied: 1976 births linked to the 1975 census, and 1981 births linked to the 1980 census. The strongest social indicator affecting birthweight was family situation: whether the woman cohabited or not. After standardization for this variable, effects were still seen for occupation and type of housing. They were not secondary to maternal age or parity. By using cohabitation status, enhanced with other social indicators, two groups were selected: one privileged and one underprivileged. Distributions of birthweight and pregnancy duration in the two groups were compared with those formed in women being neither privileged nor under privileged and also working outside the home (because occupation entered the definitions of the two former groups). There were marked differences: underprivileged women had shorter pregnancy duration and, at term, their infants weighed slightly less than those of privileged women. These differences remain after standardization for maternal age and parity.
Intellectual Impairment with Regional Cerebral Dysfunction after Low Neonatal Cerebral Blood Flow
Authors: LOU HANS C. , SKOV HANNE , HENKIKSEN LEIF 
Published: January 2008

ABSTRACTLou, H. C., Skov, H. and Henriksen, L. (Department of Neuropaediatrics, J. F. Kennedy Institute, Glostrup, and Departments of Paediatrics and Neurology, Rigshospitalet, Copenhagen, Denmark). Intellectual impairment with regional cerebral dysfunction after low neonatal cerebral blood flow. Acta Paediatr Scand Suppl 360: 72, 1989.12 children, in whom neonatal CBF had been measured, were examined at the age of 9 to 10 years by means of clinical neurological examination, neuropsychologic tests and observations, and 133Xe single photon emission computed tomography (SPECT). Performance on most neuropsychologic tests or observations correlated with neonatal CBF but only rarely with other neonatal parameters (birthweight, gestational age, Apgar score at 5 min). Poor performance on each test or observation was in most instances correlated with a distinct pattern of regional cerebral dysfunction as assessed by SPECT. The dysfunctional region tended to be located periventri‐cularly and in the watershed regions between major cerebral arteries. It is concluded that low neonatal cerebral perfusion may be an indicator, and possibly a determinant, of later intellectual dysfunction in stressed neonates, and that specific neuropsychologic deficits are associated with specific patterns of cerebral dysfunction in the present patient group.
A 15‐Year Survey of Chronic Lung Disease of Prematurity
Authors: BURNARD E. D. , JOHN E. , TODD D. A. , GRATTAN‐SMITH P. 
Published: January 2008

ABSTRACTBurnard, E. D., John, E., Todd, D. A. and Grattan‐Smith, P. (Foundation 41 and Westmead Hospital, Sydney, Australia). A 15‐year survey of chronic lung disease of prematurity. Acta Paediatr Scand Suppl 360: 120, 1989.The in‐hospital findings for infants of 500–1 500 g birthweight admitted for intensive care over the years 1971–87 were reviewed at four intervals. Survival rate improved substantially. The incidence of chronic lung disease (CLD) in survivors at 28 days of age was unchanged though severity diminished in terms of both mortality and degree of radiographic change. Mean conceptual age for ceasing supplemental oxygen was 32 weeks for those with normal X‐rays and 37 weeks for abnormal X‐rays regardless of initial degree of immaturity. CLD was diagnosed twice as often when supplemental oxygen beyond 28 days was used as an indicator as against an abnormal X‐ray and was hence unreliable for this purpose. Since candidates for CLD are a heterogeneous group care is needed in analysis or selection of material in forming conclusions which concern etiology or management.
The Role of Oral Rehydration Solutions in the Children of Europe: Continuing Controversies
Authors: WALKER‐SMITH J. A. 
Published: January 2008

ABSTRACTWalker‐Smith, J. A. (Academic Department of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London, U.K.). The role of oral rehydration solutions in the children of Europe‐ Continuing controversies. Acta Paediatr Scand Suppl 364:13, 1989.Controversy remains concerning ORS composition in Europe. This centres chiefly upon the sodium level. Solutions with a low sodium content continue to be widely used in Europe. ORS with Na 90 mmol/l when given correctly is safe and effective. However when this solution is prepared incorrectly there is a risk of hypernatraemia. In most of Europe mortality and morbidity from gastroenteritis is now very low. Therefore any change from current formulation must not carry any risk in this regard. The need for bicarbonate or indeed any base in ORS is also controversial. There is a clear need in Europe for controlled trials of ORS solutions of various composition to determine the ideal solution for the children of Europe who have acute diarrhoea.
Long‐Term Growth in Small‐for‐Date Children
Authors: FITZHARDINGE P.M. , INWOOD S. 
Published: January 2008

ABSTRACT.Fitzhardinge, P.M. and Inwood, S. (Mount Sinai Hospital, Toronto, Ontario, Canada). Long‐term growth in small‐for‐date children. Acta Paediatr Scand [Suppl] 349: 27, 1989.The growth patterns of 158 infants with significant intrauterine growth retardation (IUGR) were studied for the first 2 years of life. Eighty‐four infants were born after 36 completed weeks. All these full‐term infants survived; complete follow‐up data were obtained for 78. Acceleration of growth in weight began soon after birth and continued for an average of 6 months. Acceleration of linear growth began somewhat later, but was limited to the first 9 months. Twenty‐three infants (29%) were still below the 5th centile for both weight and height by 2 years of age. There was a negative correlation between the neonatal ponderal index and length at 18 months for females only. Seventy‐four infants were born prematurely, before 37 weeks’gestation. Mortality in this group was 18% and complete follow‐up data were obtained for 49 of the 61 survivors. Birth weight was regained on average at 11 days; accelerated weight velocity began 4–6 weeks before the expected date of delivery (term date). The potential for catch‐up growth lasted up to 9 months after the term date. By 18 months, however, 44% of these pre‐term infants were still below the 5th centile for weight. Size at 18 months post‐term was correlated with weight at the term date and length at 3 months post‐term, but not with the degree of IUGR or with the ponderal index.
Investigation of Growth Hormone Secretion in Patients with Intrauterine Growth Retardation
Authors: ROCHICCIOLI P. , TAUBER M. , MOISAN V. , PIENKOWSKI C. 
Published: January 2008

ABSTRACT.Rochiccioli, P., Tauher, M., Moisan, V. and Pienkowski C. (Department of Paediatrics, CHU Rangneil, Toulonse Cedex, France). Investigations of growth hormone secretion in patients with intrauterine growth retardation. Acta Paediatr Scand [Suppl] 349: 42, 1989.Growth hormone (GH) deficiencies have rarely been reported in intrauterine growth retardation (IUGR). This study has investigated GH secretion using GH provocation tests, 24‐hour GH secretory profiles, and insulin‐like growth factor I (IGF‐I) measurements in 24 children with intrauterine growth retardation. The criteria for diagnosis were a birth length and weight below the 10th percentile for gestational age. The average age at investigation was 5.5 years, and the average growth retardation was ‐3.3 SD. Twenty children had shown catch‐up growth between the ages of 6 months and 3 years, followed by varying decreases in growth velocity. Studies of GH secretion demonstrated GH deficiency in 16 patients, with neurosecretory dysfunction in six. Treatment with pituitary GH in nine children increased mean growth velocity from 3.5 cm/year to 7 cm/year. GH therapy should thus be effective in improving the height prognosis of children with intrauterine growth retardation.
The Wessex Growth Study: First Report
Authors: VOSS L. , WALKER J. , LUNT H. , WILKIN T. , BETTS P. 
Published: January 2008

ABSTRACT.Voss, L., Walker, J., Lunt, H., Wilkin, T. and Betts, P. (Department of Paediatrics and the Endocrine Section, Department of Medicine II, General Hospital, Southampton, UK). The Wessex growth study: first report. Acta Paediatr Scand [Suppl] 349: 65, 1989.The Wessex Growth Study is a community‐based longitudinal survey of short children recruited from two Health Districts in Wessex during 1985–86 (cohort I) and 1986–87 (cohort II). Screening of new school entrants during 1985–86 identified only 1.3% who were at or below the 3rd centile for height as defined by Tanner and Whitehouse, suggesting a strong secular trend and an urgent need for updated height charts. After exclusion of the small number of children with underlying organic pathology and those from ethnic minorities, there were 84 children in cohort I on whom this report is based. These apparently normal, short children were sex‐ and age‐matched with normal controls (10th‐90th centile) from the same school class. Forty‐two per cent of cohort I had a delayed bone age, and 34% lay above the 3rd centile after correction for parental height. Forty‐four per cent were of low birth weight. The correlation between two successive height velocities measured at 6 and 12 months was only ‐0.14 for cohort I and ‐0.15 for their controls. Twelve‐month mean height velocity SD scores (SDS) were ‐0.45 and +0.25, respectively, corresponding to the 33rd and 60th centiles, and rather higher than the 25th and 50th centiles expected in view of the heights of these children. Thirty‐eight per cent of cohort 1 had a 12‐month height velocity below the 25th centile, and in 16% height velocity was below the 10th centile. As a group, the children in cohort I grew more slowly than their controls, hut the height velocity in 88% of cases lay within the control range. For any individual, therefore, 12‐month height velocity was not a useful discriminant of growth failure. Repeated measurements are indicated.