bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Reality Relaxation for Stress in Young Adults: A Remotely Delivered Pilot Study in Participants’ Homes
Authors: Riches Simon , Kaleva Ina , Nicholson Sarah L. , Payne-Gill James , Steer Natalie , Azevedo Lisa , Vasile Ruxandra , Rumball Freya , Fisher Helen L. , Veling Wim , Valmaggia Lucia 
Published: March 2024

AbstractHigh stress levels experienced by young adults were exacerbated by COVID-19 and traditional stress management techniques can be challenging. Virtual reality (VR) relaxation appears promising and is accessible remotely; however, research on young adults is limited, especially in naturalistic settings. This remotely delivered and controlled mixed-methods study investigated feasibility and acceptability of VR relaxation for young adults (N = 23, mean age = 22.96) at home during the pandemic. VR participants (N = 11) were asked to complete daily VR relaxation sessions (scenes of virtual beaches, mountains, the sea, and more) for a 14-day intervention period, alongside visual analogue scales (VAS) of psychological well-being pre- and post-VR sessions. Post-intervention, VR participants completed semi-structured interviews. Control participants (N = 12) received no intervention. Both groups completed outcome measures of psychological well-being pre- and post-intervention periods to evaluate feasibility of remote data collection. VAS results indicated acceptability of daily VR, with significant short-term increases in relaxation, happiness, and connectedness to nature, and decreases in stress, anxiety, and sadness within VR participants. VR usage and 100% completion of outcome measures indicated feasibility of VR relaxation and remote data collection. Qualitative findings suggest participants found the VR relaxing, but interest diminished over time and technical issues hindered user experience. This suggests a more informal, less prescriptive frequency of VR use may be more appealing for young adults, although adherence may relate to technical issues. Greater interactivity and remote technical assistance within VR could increase engagement. Future research should investigate optimal frequency of use, longer-term impact, and technical issues with a larger sample.
United States Electric Utility Adaptation to Natural Hazards and Green Power Mandates
Authors: Huang Robert , Kahn Matthew E. 
Published: March 2024

AbstractAccess to electricity is a crucial determinant of quality of life and productivity. The United States has a highly reliable electricity grid, but it faces new resilience challenges due to more intense disasters and ambitious green power requirements. Over the past decade, utilities have faced tradeoffs between achieving carbon mitigation goals, offering reliable power access, and keeping retail prices low. Using a generator panel dataset from 2013 to 2022, we document that electricity generation from renewables declines during extreme weather events. Based on an electric utility panel dataset over the same period, we find that disasters also disrupt electricity distribution. Although utilities have made some adaptation progress, investments in green and reliable green power are associated with higher electricity prices.
Risk and Protective Factors for Bullying in Sport: A Scoping Review
Authors: Kalina Lisa , O’Keeffe Brendan T. , O’Reilly Siobhán , Moustakas Louis 
Published: March 2024

AbstractThe aim of the current study was to examine risk and protective factors related to bullying in sport. Adopting the methodological approach outlined by Arksey and O’Malley (International Journal of Social Research Methodology 8(1):19–32, 2005), 37 articles met the inclusion criteria. A consistent definition of bullying could not be identified in the publications examined, and several articles (n = 8) did not explicitly define bullying. The most frequent risk factor identified was an individual’s social background (n = 9). Negative influence of coaches (n = 5), level of competition (n = 5), lack of supportive club culture (n = 5) and issues in locker rooms (n = 4) were among the most commonly cited risk factors for bullying in sport settings. Preventative policies were cited as the most common method to reduce the incidence of bullying (n = 13). Contextually tailored intervention programmes (n = 5) were also noted as a key protective factor, particularly for marginalised groups, including athletes with disabilities or members of the LGBTQ+ community. The need for sport-specific bullying prevention education was highlighted by 10 of the articles reviewed. In summary, the current review accentuates the range of risk and protective factors associated with sport participation. Furthermore, the need for educational training programmes to support coaches in addressing and preventing bullying within sport settings is emphasised.
Spectral inequality with sensor sets of decaying density for Schrödinger operators with power growth potentials
Authors: Dicke Alexander , Seelmann Albrecht , Veselić Ivan 
Published: March 2024

AbstractWe prove a spectral inequality (a specific type of uncertainty relation) for Schrödinger operators with confinement potentials, in particular of Shubin-type. The sensor sets are allowed to decay exponentially, where the precise allowed decay rate depends on the potential. The proof uses an interpolation inequality derived by Carleman estimates, quantitative weighted$$L^2$$L2-estimates and an$$H^1$$H1-concentration estimate, all of them for functions in a spectral subspace of the operator.
Comparable rates of lumbar disc degeneration at long-term following adolescent idiopathic scoliosis spinal fusion extended to L3 or L4: systematic review and meta-analysis
Authors: Ruffilli Alberto , Traversari Matteo , Manzetti Marco , Viroli Giovanni , Artioli Elena , Zielli Simone Ottavio , Mazzotti Antonio , Faldini Cesare 
Published: March 2024

Abstract
Purpose
Surgical treatment of adolescent idiopathic scoliosis (AIS) requires a careful choice of fusion levels. The usual recommendation for the selection of the lowest instrumented vertebra (LIV) for double major or thoracolumbar/lumbar (TL/L) curves falls on L3 or L4. The aim of the present study is to assess if the spinal fusion with LIV selection of L3 or L4 in AIS patients has a clinical or radiological impact in terms of degenerative disc disease (DDD) in distal unfused segments at long-term follow-up.

Methods
A systematic search of electronic databases from eligible articles was conducted. Only studies regarding long-term follow-up of AIS patients treated with spinal fusion were included. Clinical and radiographic outcomes were extracted and summarized. Meta-analysis on long-term follow-up MRI studies was performed. p value < 0.05 was considered significant.

Results
Fourteen studies were included, for a total of 1264 patients. Clinical assessment of included patients showed a slight tendency to have worse clinical outcomes if spinal fusion is extended to L4 rather than L3. Despite that, meta-analysis could not be performed on clinical parameters because of heterogeneity of evaluated PROMs in included studies. Magnetic resonance imaging (MRI) evaluation at long-term follow-up showed no significant difference in terms of disc degeneration rate at overall meta-analysis (p = 0.916) between patients fused to L3 and L4.

Conclusion
The LIV selection of L3 rather than L4, according to current literature, does not prevent disc degeneration in distal unfused segments over the long term. Long-term studies of patients treated with contemporary spinal instrumentation are needed.
Adoption of Decentralization: Are Our Perceptions Holding Us Back?
Authors: Kehoe Lindsay , Calvert Sara Bristol , Hallinan Zachary , Hanger Morgan 
Published: March 2024

AbstractIncorporating decentralized approaches into clinical trials is a critical innovation with potential implications for improved accessibility and diversity, as well as lower burden for participants and caregivers. As we move forward in a collective effort to modernize clinical trials, we consistently hear of hurdles that interfere with the adoption of decentralized approaches. But are these hurdles really the impediments we think they are? In this commentary, we offer three perceptions that are commonly heard as impediments to the adoption of digital and decentralized clinical trials. Leveraging the Clinical Trial Transformation Initiative’s Digital Health Trial hub of work, interactions with members and regulators, and observations related to adoption, we address those perceptions and note some resources that exist to overcome them. In working through these barriers, we can instill confidence in sponsors and designers to leverage all the clinical trial design tools available to them to advance the use of decentralized approaches.
Towards reliable national social footprints: refining work-related injury and fatality metrics
Authors: Berthet Etienne , Anquetil-Deck Candy , Stadler Konstantin , Laurent Alexis 
Published: March 2024

Abstract
Objectives
The objective of this data note is to provide a reliable, comprehensive dataset focusing on work-related injuries and fatalities, broken down by year, country, gender, and economic sector. We aim to fill a significant gap in sustainability models, specifically in metrics concerning occupational health. Although the data is compatible with any Multi-Regional Input–Output (MRIO) model, it is primarily designed for integration with the EXIOBASE model. The dataset seeks to broaden MRIO models’ capabilities in social impact assessments and national social footprint evaluations. Ultimately, this resource aims to offer a holistic tool for researchers and policymakers, enabling more thorough assessments of international trade flows, Global Value Chains (GVC), and national policies across both environmental and social dimensions.

Data description
Our dataset enriches the EXIOBASE model with updated fatality statistics from World Health Organization (WHO) and Eurostat databases, covering the years 2008 to 2019. It provides detailed data on work-related fatal injuries by country, gender, and economic sector. With its broad applicability, this dataset stands to influence research and policy across multiple disciplines. It offers valuable insights for studies on global social impacts, policy economics, and the real effects of global value chains, among other research areas.
Using bolted connections for the construction, de-construction and reuse of lightweight exterior infill walls: Experimental study
Authors: Kitayama Shoma , Iuorio Ornella 
Published: March 2024

AbstractBolted connections offer advantages in terms of disassembly and reusability, potentially replacing conventional connections like screws, welds, or chemical bonds. This research investigates the behaviour of bolted connections between lightweight exterior infill walls and beams of primary structural members that are conventionally connected using screws. Although previous studies have investigated bolted connections in different structural members, understanding of the behaviours of these specific connections remains limited. The connections between infill walls and steel beams primarily experience shear loads under serviceability conditions. Therefore, an experimental study was conducted to gain insight into their shear behaviour. The obtained experimental results were analysed using existing predictive equations from design standards that are used across European, North American and Oceanian countries, to identify the most suitable equations for designing such connections.
Insight on prioritization of antibiotics in China, their occurrence, and removal by different wastewater treatment technologies
Authors: Bavumiragira Jean Pierre , Eheneden Iyobosa , Yin Hailong , Mumbi Anne Wambui , Quoie Gerald D. S. , Uyisaba Pascaline , Wang Rongchang , Zhao Jianfu 
Published: March 2024

AbstractChina still dominates all other nations as the world's most significant producer and consumer of antibiotics. Antibiotic misuse and overuse have been qualitatively and quantitatively documented in China recently. Antibiotic misuse has alarmed the Chinese population because some antibiotics persist in the environment and adversely affect human health and other non-target organisms. Antibiotic priority setting has been considered the best monitoring tool that is also affordable and time-efficient. Therefore, this article aims to assess the status methods of antibiotic prioritization within ten years ago years (2012–2022) in China and its prevalence and removal by conventional wastewater treatment facilities. Twenty-six priority antibiotics in China may need more attention, according to a recent prioritization assessment. According to other nations, the outcomes of prioritization vary from one nation to another. However, the same antibiotics are frequently reported despite applying various prioritization techniques (method). Their prevalence and frequent detection in China’s environmental media indicate that conventional treatment plants cannot remove them from effluents altogether. Their removal patterns vary from wastewater treatment plant (WWTP) to another and are affected by different factors, including pH, physical–chemical properties of the antibiotic compound, temperature, sludge retention time (SRT), hydraulic retention time (HRT), and the amount of microorganism present.
Graphical Abstract
Fostering effective governance through intragovernmental networks: a case of a justice, crime prevention and security cluster network
Authors: Mphahlele-Ntsasa Lebogang , Jansen van Rensburg Mari 
Published: March 2024

AbstractSouth Africa’s crime challenge remains despite substantial public sector efforts. As wicked problems, including crime, often transcend the conventional capacities of public authorities to address them effectively, the primary aim of this research was to uncover the underlying dimensions that contribute to the effective functioning of an intragovernmental collaboration network. This research adopted a case study approach to delve into the structure and efficacy of the South African Justice, Crime Prevention, and Security Cluster. The chosen methodology and insider access to senior management produced rich descriptions not previously available to offer a conceptual understanding of balances and trade-offs required during a mandated and directed collaboration. Findings offer enhanced understanding, contributing to overcoming traditional barriers in public administration networks and reforming traditional hierarchical structures to offer meaningful governance alternatives or improvements to existing structures. Specifically, this study reveals gaps in the intragovernmental network and offers insights for governance and performance enhancements. Findings emphasize the importance of fostering a collaborative culture based on performance and accountability. The study underscores the need for more robust network directives, clarifying roles and responsibilities, and enhancing leadership attributes. It stresses the importance of efficient coordination, collaborative capability, and shared purpose. The study also suggests cluster-oriented budgeting and greater involvement of key stakeholders, including civil societies, research institutions, and academic establishments. These findings contribute to improving government-led networks in addressing complex challenges.
Inequality, urbanism, and governance at Coba and the Northern Maya Lowlands
Authors: Hutson Scott R. , Stanton Travis W. , Ardren Traci 
Published: March 2024

AbstractGini coefficients for residential groups at Coba for roofed surface area, volume of architecture, and houselot space range from 0.423 to 0.551, fitting well within the range of many ancient and modern state-level cities and societies and other Mesoamerican centers. These values are also similar to other large, Classic period, Northern Lowland cities, such as Dzibilchaltun and Chunchucmil. These data do not support the idea that autocratic regimes exhibit greater wealth inequality. We also failed to find a pattern in which inequality grew over the course of the Classic period. The Lorenz curves for Coba and other sites do not indicate any breaks that would allow households to be sorted into wealth classes. Thus, wealth differences were fluid, continuous, and out in the open, giving these settlements the dynamism and attractiveness that helped them grow into some of the largest and most remarkable ancient Maya cities.
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression
Authors: Liu Zhonglong , Meng Xiaoyan , Zhang Yuxin , Sun Jingjing , Tang Xiao , Zhang Zhiyuan , Liu Liu , He Yue 
Published: March 2024

Abstract
SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression. Aberrant glycosylation has been intricately linked with immune escape and tumor growth. SEMA7A is a highly glycosylated protein with five glycosylated sites. The underlying mechanisms of SEMA7A glycosylation and its contribution to immunosuppression and tumorigenesis are unclear. Here, we identify overexpression and aberrant N-glycosylation of SEMA7A in head and neck squamous cell carcinoma, and elucidate fucosyltransferase FUT8 catalyzes aberrant core fucosylation in SEMA7A at N-linked oligosaccharides (Asn 105, 157, 258, 330, and 602) via a direct protein‒protein interaction. A glycosylated statue of SEMA7A is necessary for its intra-cellular trafficking from the cytoplasm to the cytomembrane. Cytokine EGF triggers SEMA7A N-glycosylation through increasing the binding affinity of SEMA7A toward FUT8, whereas TGF-β1 promotes abnormal glycosylation of SEMA7A via induction of epithelial–mesenchymal transition. Aberrant N-glycosylation of SEMA7A leads to the differentiation of CD8+ T cells along a trajectory toward an exhausted state, thus shaping an immunosuppressive microenvironment and being resistant immunogenic cell death. Deglycosylation of SEMA7A significantly improves the clinical outcome of EGFR-targeted and anti-PD-L1-based immunotherapy. Finally, we also define RBM4, a splice regulator, as a downstream effector of glycosylated SEMA7A and a pivotal mediator of PD-L1 alternative splicing. These findings suggest that targeting FUT8-SEMA7A axis might be a promising strategy for improving antitumor responses in head and neck squamous cell carcinoma patients.
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants
Authors: Hayes Tikvah K. , Aquilanti Elisa , Persky Nicole S. , Yang Xiaoping , Kim Erica E. , Brenan Lisa , Goodale Amy B. , Alan Douglas , Sharpe Ted , Shue Robert E. , Westlake Lindsay , Golomb Lior , Silverman Brianna R. , Morris Myshal D. , Fisher Ty Running , Beyene Eden , Li Yvonne Y. , Cherniack Andrew D. , Piccioni Federica , Hicks J. Kevin , Chi Andrew S. , Cahill Daniel P. , Dietrich Jorg , Batchelor Tracy T. , Root David E. , Johannessen Cory M. , Meyerson Matthew 
Published: March 2024

AbstractThe epidermal growth factor receptor, EGFR, is frequently activated in lung cancer and glioblastoma by genomic alterations including missense mutations. The different mutation spectra in these diseases are reflected in divergent responses to EGFR inhibition: significant patient benefit in lung cancer, but limited in glioblastoma. Here, we report a comprehensive mutational analysis of EGFR function. We perform saturation mutagenesis of EGFR and assess function of ~22,500 variants in a human EGFR-dependent lung cancer cell line. This approach reveals enrichment of erlotinib-insensitive variants of known and unknown significance in the dimerization, transmembrane, and kinase domains. Multiple EGFR extracellular domain variants, not associated with approved targeted therapies, are sensitive to afatinib and dacomitinib in vitro. Two glioblastoma patients with somatic EGFR G598V dimerization domain mutations show responses to dacomitinib treatment followed by within-pathway resistance mutation in one case. In summary, this comprehensive screen expands the landscape of functional EGFR variants and suggests broader clinical investigation of EGFR inhibition for cancers harboring extracellular domain mutations.
Microevolution, reinfection and highly complex genomic diversity in patients with sequential isolates of Mycobacterium abscessus
Authors: Buenestado-Serrano Sergio , Martínez-Lirola Miguel , Herranz-Martín Marta , Esteban Jaime , Broncano-Lavado Antonio , Molero-Salinas Andrea , Sanz-Pérez Amadeo , Blázquez Jesús , Ruedas-López Alba , Toro Carlos , López-Roa Paula , Domingo Diego , Zamarrón Ester , Ruiz Serrano María Jesús , Muñoz Patricia , Pérez-Lago Laura , García de Viedma Darío 
Published: March 2024

AbstractMycobacterium abscessus is an opportunistic, extensively drug-resistant non-tuberculous mycobacterium. Few genomic studies consider its diversity in persistent infections. Our aim was to characterize microevolution/reinfection events in persistent infections. Fifty-three sequential isolates from 14 patients were sequenced to determine SNV-based distances, assign resistance mutations and characterize plasmids. Genomic analysis revealed 12 persistent cases (0-13 differential SNVs), one reinfection (15,956 SNVs) and one very complex case (23 sequential isolates over 192 months), in which a first period of persistence (58 months) involving the same genotype 1 was followed by identification of a genotype 2 (76 SNVs) in 6 additional alternating isolates; additionally, ten transient genotypes (88-243 SNVs) were found. A macrolide resistance mutation was identified from the second isolate. Despite high diversity, the genotypes shared a common phylogenetic ancestor and some coexisted in the same specimens. Genomic analysis is required to access the true intra-patient complexity behind persistent infections involving M. abscessus.
Catalytic polymer self-cleavage for CO2 generation before combustion empowers materials with fire safety
Authors: Luo Wei , Chen Ming-Jun , Wang Ting , Feng Jin-Feng , Fu Zhi-Cheng , Deng Jin-Ni , Yan Yuan-Wei , Wang Yu-Zhong , Zhao Hai-Bo 
Published: March 2024

AbstractPolymeric materials, rich in carbon, hydrogen, and oxygen elements, present substantial fire hazards to both human life and property due to their intrinsic flammability. Overcoming this challenge in the absence of any flame-retardant elements is a daunting task. Herein, we introduce an innovative strategy employing catalytic polymer auto-pyrolysis before combustion to proactively release CO2, akin to possessing responsive CO2 fire extinguishing mechanisms. We demonstrate that potassium salts with strong nucleophilicity (such as potassium formate/malate) can transform conventional polyurethane foam into materials with fire safety through rearrangement. This transformation results in the rapid generation of a substantial volume of CO2, occurring before the onset of intense decomposition, effectively extinguishing fires. The inclusion of just 1.05 wt% potassium formate can significantly raise the limiting oxygen index of polyurethane foam to 26.5%, increase the time to ignition by 927%, and tremendously reduce smoke toxicity by 95%. The successful application of various potassium salts, combined with a comprehensive examination of the underlying mechanisms, underscores the viability of this strategy. This pioneering catalytic approach paves the way for the efficient and eco-friendly development of polymeric materials with fire safety.