bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation on pore characteristics of vitrain and durain in low rank coal based on fractal theory
Authors: Zheng Chao , Chen Yue , Yu Lan , Lei Wulin , Du Xuanhong , Yang Fengfeng 
Published: February 2024

AbstractThe macro petrographic compositions and its pore characteristics of coal reservoir play critical role in the accumulation and development of coalbed methane (CBM). In this paper, the pore characteristics of vitrain and durain were analyzed through the experiment and fractal theory. The results indicated that the micropores and microfractures develop in vitrain, and that transitional pores develop in durain. The pore volume and specific surface area (SSA) of vitrain are larger than those of durain, with the micropore SSA of vitrain being 35% higher than that of durain. The threshold pressure and tortuosity of vitrain are greater than that of durain, but the mean pore size of vitrain is smaller than that of durain. The fractal dimension D1 of vitrain is greater than that of durain, while the fractal dimension D2 is opposite, indicating that the pore surface of vitrain is coarser, and the pore structure of durain is more complex. The fractal dimension Dk of vitrain is larger than that of durain, the mean fractal dimension Ds of vitrain is smaller than that of durain, which shows that the diffusivity of vitrain is weak but the seepage capacity is strong due to the developed fractures. The difference in material composition and pore characteristics between vitrain and durain provides a new understanding for the development of CBM in low rank coal.
Attention-guided jaw bone lesion diagnosis in panoramic radiography using minimal labeling effort
Authors: Gwak Minseon , Yun Jong Pil , Lee Ji Yun , Han Sang-Sun , Park PooGyeon , Lee Chena 
Published: February 2024

AbstractDeveloping a deep-learning-based diagnostic model demands extensive labor for medical image labeling. Attempts to reduce the labor often lead to incomplete or inaccurate labeling, limiting the diagnostic performance of models. This paper (i) constructs an attention-guiding framework that enhances the diagnostic performance of jaw bone pathology by utilizing attention information with partially labeled data; (ii) introduces an additional loss to minimize the discrepancy between network attention and its label; (iii) introduces a trapezoid augmentation method to maximize the utility of minimally labeled data. The dataset includes 716 panoramic radiograph data for jaw bone lesions and normal cases collected and labeled by two radiologists from January 2019 to February 2021. Experiments show that guiding network attention with even 5% of attention-labeled data can enhance the diagnostic accuracy for pathology from 92.41 to 96.57%. Furthermore, ablation studies reveal that the proposed augmentation methods outperform prior preprocessing and augmentation combinations, achieving an accuracy of 99.17%. The results affirm the capability of the proposed framework in fine-grained diagnosis using minimally labeled data, offering a practical solution to the challenges of medical image analysis.
Strategy to improve synaptic behavior of ion-actuated synaptic transistors—the use of ion blocking layer to improve state retention
Authors: Jeon Seonuk , Tessler Nir , Kim Nayeon , Hong Eunryeong , Kim Hyun Wook , Woo Jiyong 
Published: February 2024

AbstractSynaptic transistors (STs) with a gate/electrolyte/channel stack, where mobile ions are electrically driven across the solid electrolyte, have been considered as analog weight elements for neuromorphic computing. The current (ID) between the source and drain in the ST is analogously updated by gate voltage (VG) pulses, enabling high pattern recognition accuracy in neuromorphic systems; however, the governing physical mechanisms of the ST are not fully understood yet. Our previous physics-based simulation study showed that ion movement in the electrolyte, rather than the electrochemical reactions that occur in the channel, plays an important role in switching. In this study, we experimentally explore the properties of the HfOxelectrolyte and show that by tuning the density of oxygen vacancies, it can assume the dual role of electrolyte and channel. We demonstrate analog synaptic behavior using a novel ST with a two-layer stack of CuOx/HfOx, where the CuOxis the gate and Cu ion reservoir, and the HfOxis the electrolyte and channel. To improve state retention and linearity, we introduce a Cu ion transport barrier in the form of a dense and stoichiometric Al2O3layer. The CuOx/Al2O3/HfOxexhibits excellent state retention and improved potentiation and depression response. Energy dispersive spectroscopy mapping following potentiation confirms the role of the Al2O3layer in confining the Cu ions in the HfOxlayer. We also show that a two-step programming scheme can further enhance synaptic response and demonstrate high recognition accuracy on the Fashion-MNIST dataset in simulation.
Long-term air pollution exposure is associated with higher incidence of ST-elevation myocardial infarction and in-hospital cardiogenic shock
Authors: Cha Jinah , Choi Se Yeon , Rha Seung-Woon , Choi Byoung Geol , Byun Jae Kyeong , Hyun Sujin , Lee Min Woo , Kang Jaeho , Chu Wonsang , Park Eun Jin , Kang Dong Oh , Choi Cheol Ung , Kim Suhng Wook , Jeong Myung Ho , Park Soohyung ,   The Korea Acute Myocardial Infraction Registry study group, Rha Seung-Woon , Ahn Tae Hoon , Yoon Junghan , Kim Hyo-Soo , Seung Ki-Bae , Gwon Hyeon-Cheol , Chae Shung Chull , Kim Chong-Jin , Cha Kwang Soo , Lee Jung-Hee , Chae Jei Keon , Joo Seung-Jae , Yoon Chang-Hwan , Hur Seung-Ho , Seong In-Whan , Hwang Kyung-Kuk , Kim Doo-Il , Oh Seok Kyu , Hwang Jin-Yong , Jeong Myung Ho 
Published: February 2024

AbstractPrevious studies have reported the association between myocardial infarction (MI) and air pollution (AP). However, limited information is available regarding the long-term effects of AP on the relative incidence rates of ST-elevation MI (STEMI) and Non-ST-elevation MI (NSTEMI). We investigated the association between long-term exposure to AP and the incidence of STEMI. Between January 2006 and December 2015, a total of 45,619 eligible patients with Acute Myocardial Infarction (AMI) were enrolled in the Korea Acute MI Registry (KAMIR) and KAMIR-National Institutes of Health. Mixed-effect regression models were used to examine the association between the annual average ambient AP before MI onset and the incidence of STEMI, and to evaluate the association of AP with the incidence of in-hospital cardiogenic shock. After mixed-effect regression model analysis, particulate matter (PM) 10 µm or less in diameter (PM10) was associated with increased incidence of STEMI compared with NSTEMI (odds ratio [OR] 1.009, 95% Confidence Interval [CI] 1.002–1.016; p = 0.012). For in-hospital cardiogenic shock complication, PM10 and SO2 were associated with increased risk, PM10 (OR 1.033, 95% CI 1.018–1.050; p < 0.001), SO2 (OR 1.104, 95% CI 1.006–1.212; p = 0.037), respectively. Policy-level strategies and clinical efforts to reduce AP exposure are necessary to prevent the incidence of STEMI and severe cardiovascular complications.
Continuous adiabatic frequency conversion for FMCW-LiDAR
Authors: Mrokon Alexander , Oehler Johanna , Breunig Ingo 
Published: February 2024

AbstractContinuous tuning of the frequency of laser light serves as the fundamental basis for a myriad of applications spanning basic scientific research to industrial settings. These applications encompass endeavors such as the detection of gravitational waves, the development of precise optical clocks, environmental monitoring for health and ecological purposes, as well as distance measurement techniques. However, achieving a broad tuning range exceeding 100 GHz along with sub-microsecond tuning times, inherent linearity in tuning, and coherence lengths beyond 10 m presents significant challenges. Here, we demonstrate that electro-optically driven adiabatic frequency converters utilizing high-Q microresonators fabricated from lithium niobate possess the capability to convert arbitrary voltage signals into frequency chirps with temporal resolutions below 1 µs. The temporal evolution of the frequency correlates accurately with the applied voltage signal. We have achieved to generate 200-ns-long frequency chirps with deviations of less than 1 % from perfect linearity without requiring supplementary measures. The coefficient of determination is $$R^2>0.999$$

R
2

>
0.999

. Moreover, the coherence length of the emitted light exceeds 20 m. To validate these findings, we employ the linear frequency sweeps for Frequency-Modulated Continuous Wave (FMCW) LiDAR covering distances ranging from 0.5 to 10 m. Leveraging the demonstrated nanosecond-level tuning capabilities, coupled with the potential to tune the eigenfrequency of lithium-niobate-based resonators by several hundred GHz, our results show that electro-optically driven adiabatic frequency converters can be used in applications that require ultrafast and flexible continuous frequency tuning characterized by inherent linearity and substantial coherence length.
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis
Authors: Ma Lingli , Dong Ying , Li Zimeng , Meng Jian , Zhao Bingqi , Wang Qing 
Published: February 2024

AbstractDiabetic retinopathy (DR) is the most frequent microvascular complication of diabetes mellitus, however, its underlying biological mechanisms remain poorly understood. We examined single nucleotide polymorphisms linked to 486 blood metabolites through extensive genome-wide association studies conducted on individuals of European ancestry. The FinnGen Biobank database served as a reference to define DR. Two-sample MR analysis was conducted to reveal the association between the levels of genetically predicted circulating metabolites and the susceptibility to DR. To validate the robustness of the obtained findings, sensitivity analyses with weighted median, weighted mode, and MR-Egger were conducted. 1-oleoylglycerophosphoethanolamine (odds ratio [OR] (OR per one standard deviation [SD] increase) = 0.414; 95% confidence interval [CI] 0.292–0.587; P = 7.613E−07, PFDR = 6.849E−06), pyroglutamine (OR per one SD increase = 0.414; 95% confidence interval [CI] 0.292–0.587; P = 8.31E−04, PFDR = 0.007), phenyllactate (PLA) (OR per one SD increase = 0.591; 95% confidence interval [CI] 0.418–0.836; P = 0.003, PFDR = 0.026), metoprolol acid metabolite (OR per one SD increase = 0.978; 95% confidence interval [CI] 0.962–0.993; P = 0.005, PFDR = 0.042), 10-undecenoate (OR per one SD increase = 0.788; 95% confidence interval [CI] 0.667–0.932; P = 0.005, PFDR = 0.049), erythritol (OR per one SD increase = 0.691; 95% confidence interval [CI] 0.513–0.932; P = 0.015, PFDR = 0.034), 1-stearoylglycerophosphoethanolamine (OR per one SD increase = 0.636; 95% confidence interval [CI] 0.431–0.937; P = 0.022, PFDR = 0.099), 1-arachidonoylglycerophosphoethanolamine (OR per one SD increase = 0.636; 95% confidence interval [CI] 0.431–0.937; P = 0.030, PFDR = 0.099) showed a significant causal relationship with DR and could have protective effects. stachydrine (OR per one SD increase = 1.146; 95% confidence interval [CI] 1.066–1.233; P = 2.270E−04, PFDR = 0.002), butyrylcarnitine (OR per one SD increase = 1.117; 95% confidence interval [CI] 1.023–1.219; P = 0.014, PFDR = 0.062), 5-oxoproline (OR per one SD increase = 1.569; 95% confidence interval [CI] 1.056–2.335; P = 0.026, PFDR = 0.082), and kynurenine (OR = 1.623; 95% CI 1.042–2.526; P = 0.041, PFDR = 0.097) were significantly associated with an increased risk of DR. This study identified metabolites have the potential to be considered prospective compounds for investigating the underlying mechanisms of DR and for selecting appropriate drug targets.
The chemical stoichiometry characteristics of plant-soil carbon and nitrogen in subtropical Pinus massoniana natural forests
Authors: Xiang Yunxi , Pan Ping , Ouyang Xunzhi , Zang Hao , Rao Jinfeng 
Published: February 2024

AbstractEcological stoichiometry is essential for understanding changes in ecosystem structure and nutrient cycling in forest ecosystems. However, the stoichiometric characteristics of carbon (C) and nitrogen (N) in different organs or layers, such as leaves, branches, trunks, roots, understory vegetation, litter, and soil within a forest ecosystem, have remained poorly understood. In this study, four age groups of Pinus massoniana natural forest including young, middle-aged, near-mature, and mature were selected as research subjects to illustrate the C and N stoichiometry interactions among different layers and organs in the forest ecosystem. The results showed that the average C and N concentrations in the leaves of the tree layer, shrub layer, and herb aboveground parts (HAP) were higher than that of other tree and shrub organs, as well as the herb underground parts (HUP), respectively. The N concentrations of tree branches and trunks showed a trend of increase first and decrease later from young to mature phases, but the C:N ratios presented an opposite trend. The C concentrations.in all tissues in shrubs showed a first decline and then a rise with age. As age progressed, the N concentration in each ecosystem layer increased gradually and demonstrated high synergy. The mineralization of organic matter in the soil was generally slow. The C concentrations in the understory vegetation layer were significantly positively correlated with the C concentrations in the litter layer but negatively correlated with the soil layer, and the C concentrations in the litter layer were also significantly negatively correlated with the C concentrations in the soil layer. The research findings can provide a reference basis for the formulation of nutrient regulation and sustainable management measures in the natural forests of P. massoniana in the study area.
MALAT1 expression in granulosa cells in PCOS patients with different phenotypes
Authors: Li Shumin , Li Yimeng , Yan Xueqi , Zhao Shigang , Yang Ziyi , Wang Yuteng , Gao Xueying , Chen Zi-Jiang 
Published: February 2024

AbstractPolycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine metabolic disorders. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) reportedly can regulate the reproductive system. Despite studies, the alteration of MALAT1 expression in granulosa cells (GCs) from PCOS patients was inconsistent. To evaluate MALAT1 expression in GCs in different PCOS subgroups and its association with PCOS phenotypes, we collected GCs from 110 PCOS cases and 71 controls, and examined MALAT1 expression by quantitative PCR. The results showed MALAT1 expression was upregulated in PCOS cases, especially in insulin resistant (IR) PCOS subgroup, obese PCOS subgroup and non-hyperandrogenic (NHA) PCOS subgroup. MALAT1 expression was positively correlated with BMI and several metabolic parameters in controls. Interestingly, MALAT1 expression was notably associated with some critical endocrine indexes for PCOS, including E2, FSH, LH and LH/FSH ratio. In different PCOS subgroups, we found significant positive correlations with LH/FSH ratio in IR-PCOS and PCOS with normal weight, and with serum T and LH level in NHA-PCOS subgroup. Integrated analysis with lncRNA target databases and PCOS-related databases revealed MALAT1 could participate in PCOS by influencing immune response and lipids metabolism in GCs. In conclusion, MALAT1 was differently expressed in GCs in PCOS, especially in IR, obese and NHA PCOS subgroups. MALAT1 was likely involved in metabolism and immune response in GCs in PCOS. However, more studies are necessary to establish this concept.
A multi-objective optimization evaluation model for seismic performance of slopes reinforced by pile-anchor system
Authors: Xue Lei , Li Longfei , Xu Chao , Cui Yuan , Ding Hao , Huang Kun , Li Zhuan 
Published: February 2024

AbstractThe significance means of the seismic reinforcement effect of a pile-anchor system for slope reinforcement has been widely recognized. However, cases of deformation failure and instability sliding of the pile-anchor system itself and the reinforced slope under seismic action continue to be recorded. Therefore, it is crucial to evaluate the seismic performance of slopes reinforced by a pile-anchor system to prevent the system’s failure. Current evaluation models of a slope reinforced by a pile-anchor system mainly focus on slope stability; however, the safety of the pile-anchor system itself is not sufficiently considered in these models. Consequently, in this study, we propose a multi-objective optimization evaluation (MOE) model for evaluating the seismic performance of slopes reinforced by a pile-anchor system that considers slope stability, safety of the pile-anchor system, and dynamic response of the slope. This model considers slope displacement, acceleration amplification factor of a slope, pile displacement, and anchor displacement as negative indexes, and anti-slide pile bending moment, shear force, and anchor axial force as intermediate indexes. The comprehensive weight of relevant indexes is obtained by combining subjective and objective weights, and the seismic reinforcement effect of the pile-anchor system is evaluated subsequently. In conclusion, the MOE model proposed in this study provides a novel solution for the optimization evaluation of a slope reinforced by a pile-anchor system in forthcoming projects.
Designing a T-cell epitope-based vaccine using in silico approaches against the Sal k 1 allergen of Salsola kali plant
Authors: Shams Mohammad Hossein , Sohrabi Seyyed Mohsen , Jafari Reza , Sheikhian Ali , Motedayyen Hossein , Baharvand Peyman Amanolahi , Hasanvand Amin , Fouladvand Ali , Assarehzadegan Mohammad-Ali 
Published: February 2024

AbstractAllergens originated from Salsola kali (Russian thistle) pollen grains are one of the most important sources of aeroallergens causing pollinosis in desert and semi-desert regions. T-cell epitope-based vaccines (TEV) are more effective among different therapeutic approaches developed to alleviate allergic diseases. The physicochemical properties, and B as well as T cell epitopes of Sal k 1 (a major allergen of S. kali) were predicted using immunoinformatic tools. A TEV was constructed using the linkers EAAAK, GPGPG and the most suitable CD4+ T cell epitopes. RS04 adjuvant was added as a TLR4 agonist to the amino (N) and carboxyl (C) terminus of the TEV protein. The secondary and tertiary structures, solubility, allergenicity, toxicity, stability, physicochemical properties, docking with immune receptors, BLASTp against the human and microbiota proteomes, and in silico cloning of the designed TEV were assessed using immunoinformatic analyses. Two CD4+ T cell epitopes of Sal k1 that had high affinity with different alleles of MHC-II were selected and used in the TEV. The molecular docking of the TEV with HLADRB1, and TLR4 showed TEV strong interactions and stable binding pose to these receptors. Moreover, the codon optimized TEV sequence was cloned between NcoI and XhoI restriction sites of pET-28a(+) expression plasmid. The designed TEV can be used as a promising candidate in allergen-specific immunotherapy against S. kali. Nonetheless, effectiveness of this vaccine should be validated through immunological bioassays.
Hygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway
Authors: Chi Jianing , Wu Ningxia , Li Pengfei , Hu Jiaman , Cai Hua , Lin Cailong , Lai Yingying , Yang Han , Huang Jianyu , Li Min , Xu Lin 
Published: February 2024

AbstractHigh mortality due to hygrothermal stress during heat waves is mostly linked to cardiovascular malfunction, the most serious of which are malignant arrhythmias. However, the mechanism associated with hygrothermal stress leading to malignant arrhythmias remains unclear. The energy metabolism regulated by liver kinase B1 (LKB1) and adenosine monophosphate-activated protein kinase (AMPK) and the electrical signaling based on gap junction protein, connexin43 (Cx43), plays important roles in the development of cardiac arrhythmias. In order to investigate whether hygrothermal stress induces arrhythmias via the LKB1-AMPK-Cx43 pathway, Sprague–Dawley rats were exposed to high temperature and humidity for constructing the hygrothermal stress model. A final choice of 40 °C and 85% humidity was made by pre-exploration based on different gradient environmental conditions with reference to arrhythmia event-inducing stability and risk of sudden death. Then, the incidence of arrhythmic events, as well as the expression, phosphorylation at Ser368, and distribution of Cx43 in the myocardium, were examined. Meanwhile, the adenosine monophosphate-activated protein kinase activator, Acadesine, was also administered to investigate the role played by AMPK in the process. Our results showed that hygrothermal stress induced malignant arrhythmias such as ventricular tachycardia, ventricular fibrillation, and severe atrioventricular block. Besides, hygrothermal stress decreased the phosphorylation of Cx43 at Ser368, induced proarrhythmic redistribution of Cx43 from polar to lateral sides of the cardiomyocytes, and also caused LKB1 and phosphorylated-AMPK expression to be less abundant. While, pretreatment with Acadesine significantly actived the LKB1-AMPK-Cx43 pathway and thus ameliorated malignant arrhythmias, indicating that the hygrothermal stress-induced arrhythmias is associated with the redistribution of gap junctions in cardiomyocytes and the organism's energy metabolism.
Novel hydrophobic butyl rubber damping composites modified with bio-based PF/DBA via the construction of a three-dimensional network
Authors: Hu Zhenguo , Chen Zeyu , Meng Fuliang , Zhang Yimiao , Jia Yufei , Fei Hongwei , Li Songjun , Yuan Xinhua 
Published: February 2024

AbstractIt is of interest to develop wide-temperature domain damped hydrophobic materials. In this paper, we designed incorporating bio-based phenolic resin into the IIR matrix and introducing dibenzyl fork acetone (DBA) into the main chain structure with sodium hydroxide activation to construct three-dimensional network. In this paper, we designed incorporating bio-based phenolic resin into the IIR matrix and introducing dibenzyl fork acetone (DBA) into the main chain structure with sodium hydroxide activation to construct three-dimensional network. The added bio-based phenolic resin has reticulated structure blended with butyl rubber, combined with sodium hydride activation-modified IIR. The results show that sodium hydride activated modification of DBA is introduced into the main chain structure of IIR by infrared and 1H NMR analysis. The material hydrophobic is realized by the introduction of DBA with static water contact angle of 103.5°. The addition of 10phr lignin-based phenolic resin (LPF) is compatible with IIR, and the torque can reach 7.0 N-m. The tensile elongation of the modified butyl rubber composite can reach 2400% with tensile strength up to 11.43 MPa, while the damping factor can reach 0.37 even at 70 °C. The thermal stability of the composites is enhanced with mass retention rate of 28%. The bio-based PF/NaH activation-modified butyl rubber damping material has potential applications in damping hydrophobicity with wide temperature range.