bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal changes in biomarkers of neutrophil extracellular traps and NET‐promoting autoantibodies following adenovirus‐vectored, mRNA, and recombinant protein COVID‐19 vaccination
Authors: Kuo Yu‐Min , Kang Chun‐Min , Lai Zhi‐Yun , Huang Ting‐Yu , Tzeng Shiang‐Jong , Hsu Chih‐Chieh , Chen Shey‐Ying , Hsieh Song‐Chou , Chia Jean‐San , Jung Chiau‐Jing , Hsueh Po‐Ren 
Published: March 2024

AbstractNeutrophil extracellular traps (NETs) play a role in innate pathogen defense and also trigger B‐cell response by providing antigens. NETs have been linked to vaccine‐induced thrombotic thrombocytopenia. We postulated a potential link between NET biomarkers, NET‐promoting autoantibodies, and adverse events (AEs) after COVID‐19 vaccine boosters. Healthy donors (HDs) who received ChAdOx1‐S (A), mRNA‐1273 (M), or recombinant protein (MVC–COV1901) vaccines at the National Taiwan University Hospital between 2021 and 2022 were recruited. We measured serial NET‐associated biomarkers, citrullinated‐histone3 (citH3), and myeloperoxidase (MPO)‐DNA. Serum citH3 and MPO‐DNA were significantly or numerically higher in HDs who reported AEs (n = 100, booster Day 0/Day 30, p = 0.01/p = 0.03 and p = 0.30/p = 0.35, respectively). We also observed a positive correlation between rash occurrence in online diaries and elevated citH3. A linear mixed model also revealed significantly higher citH3 levels in mRNA‐1273/ChAdOx1‐S recipients than MVC‐COV1901 recipients. Significant positive correlations were observed between the ratios of anti‐heparin platelet factor 4 and citH3 levels on Booster Day 0 and naïve and between the ratios of anti‐NET IgM and citH3 on Booster Day 30/Day 0 in the AA‐M and MM‐M group, respectively. The increased levels of citH3/MPO‐DNA accompanied by NET‐promoting autoantibodies suggest a potential connection between mRNA‐1273/ChAdOx1‐S vaccines and cardiovascular complications. These findings provide insights for risk assessments of future vaccines.
The impact of entrepreneurial hubris and narcissism on personal social responsibility
Authors: Emami Amir , Welsh Dianne H. B. , Hakimian Roohollah 
Published: March 2024

AbstractThis study aims to investigate the effect of entrepreneurs' hubris and narcissism operating in Tehran's Science and Technology Parks (STPs) on personal social responsibility (PSR). The study employed a cross‐sectional survey method with gender and experience as moderators. Results show that entrepreneurs' narcissism positively affects their social responsibility, while entrepreneurs' hubris negatively affects their social responsibility. Gender moderates the relationship between entrepreneurs' hubris and narcissism on PSR. Our findings suggest that personality traits (i.e., narcissism and hubris) and gender play a more critical role in an entrepreneur's tendency toward social responsibility than experience. Implications for future research and practical applications are discussed.
Research on etalon‐free CO2 measurement based on direct absorption signal fitting
Authors: Yang Yan , Guo Songjie , Li Jiatong , Wei Youxing , Lu Zhimin , Xing Xiwen , Ren Wei , Zhang Xiang , Yao Shunchun 
Published: March 2024

AbstractThe emission of carbon dioxide (CO2) by thermal power plants is the main factor leading to the greenhouse effect. The measurement of CO2 is of great significance to carbon emission data statistics. In this paper, a measurement system based on tunable diode laser absorption spectroscopy (TDLAS) was built to measure the spectrum of CO2 near 1579 nm. To simplify the experimental system, a direct absorption signal fitting method is proposed to replace etalons for time‐frequency conversion. The method was applied to the measurement of four different concentrations of CO2 in the range of 7%–16%, and the measurement results were compared with the multipeak method, another etalon‐free method. The results show that the mean relative error of the measurement results is 4.23%, which is 1.76% lower than the measurement results of the multipeak method. The experimental research provides a feasible idea to simplify the CO2 measurement system based on TDLAS.
Environmentally stable all‐fiber femtosecond laser for industrial application based on a SESAM mode‐locked ytterbium‐doped laser
Authors: Cao Xue , Li Feng , Song Dongdong , Wang Yishan , Li Qianglong , Zhao Hualong , Zhao Wei , Wen Wenlong , Si Jinhai 
Published: March 2024

AbstractWe demonstrate an environmentally stable femtosecond laser for industrial application based on all polarization‐maintaining Yb‐doped laser and experimentally explore the effect of the net cavity dispersion (NCD) on output characteristics. The oscillator emits pulses with 5.1 ps and a 23 nm spectral bandwidth, then the pulse is compressed to 88 fs. The instabilities over 120 h gives 0.32% relative root mean square noise, indicating high stability of the pulse laser. With effective regulation of NCD, we obtained the maximum spectral bandwidth of 27 nm. Such broadband oscillator with compact all‐fiber configurations provide extremely high stability should be very attractive for long‐term industrial application.
The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation
Authors: Stevenson K. , Hadley‐Barrows T. , Evans N. , Campbell L. , Southam J. , Chudyk A. , Ellington D. , Jeeves B. , Jenson C. , Kleberg S. , Birkinshaw H. , Mair F. , Dziedzic K. , Peat G. , Jordan K. P. , Yu D. , Bailey J. , Braybooke A. , Mallen C. D. , Hill Jonathan C. 
Published: March 2024

AbstractIntroductionGlobally, back pain is the leading cause of years of disability. In the United Kingdom, over 20 million people live with musculoskeletal (MSK) pain, with low back pain being one of the most common causes. National strategies promote self‐management and the use of digital technologies to empower populations.AimsTo evaluate the uptake and impact of providing the SelfSTart approach (STarT Back and SelfBACK App) when delivered by a First Contact Physiotherapist (FCP) to people presenting with low back pain in primary care.MethodsPatients presenting with a new episode of low back pain underwent routine assessment and completion of a STarT Back questionnaire. Patients with low/medium scores were offered the SelfBACK App. A control population was provided by the MIDAS‐GP study. Patient Experience, outcome measures, healthcare utilisation and retention were captured through the app and clinical systems (EMIS). Interviews with five FCPs explored the experiences of using the SelfSTart approach.ResultsSelfSTarT was taken up by almost half (48%) of those to whom it was offered. Compared to MIDAS‐GP, users were more likely to be younger, male, in work, and with higher health literacy. SelfSTarT users reported significant improved experiences relating to receiving an agreed care plan and receiving sufficient information. There were no significant differences in treatments offered. FCPs were positive about the app and felt it had value but wanted feedback on patient progress. They recognised that a digital solution would not be suitable for all.ConclusionThis approach offers an opportunity to empower and support self‐management, using robustly evaluated digital technology.
Leveraging the Hankel norm approximation and data‐driven algorithms in reduced order modeling
Authors: Yu Annan , Townsend Alex 
Published: March 2024

SummaryLarge‐scale linear time‐invariant (LTI) dynamical systems are widely used to characterize complicated physical phenomena. Glover developed the Hankel norm approximation (HNA) algorithm for optimally reducing the system in the Hankel norm, and we study its numerical issues. We provide a remedy for the numerical instabilities of Glover's HNA algorithm caused by clustered singular values. We analyze the effect of our modification on the degree and the Hankel error of the reduced system. Moreover, we propose a two‐stage framework to reduce the order of a large‐scale LTI system given samples of its transfer function for a target degree of the reduced system. It combines the adaptive Antoulas–Anderson (AAA) algorithm, modified to produce an intermediate LTI system in a numerically stable way, and the modified HNA algorithm. A carefully computed rational approximation of an adaptively chosen degree gives us an algorithm for reducing an LTI system, which achieves a balance between speed and accuracy.
Utilization of broad‐ versus narrow‐spectrum antibiotics for the treatment of outpatient community‐acquired pneumonia among adults in the United States
Authors: Nickel Katelin B. , Durkin Michael J. , Olsen Margaret A. , Sahrmann John M. , Neuner Elizabeth , O'Neil Caroline A. , Butler Anne M. ,   for the CDC Prevention Epicenters Program
Published: March 2024

AbstractPurposeTo characterize antibiotic utilization for outpatient community‐acquired pneumonia (CAP) in the United States.MethodsWe conducted a cohort study among adults 18–64 years diagnosed with outpatient CAP and a same‐day guideline‐recommended oral antibiotic fill in the MarketScan® Commercial Database (2008–2019). We excluded patients coded for chronic lung disease or immunosuppressive disease; recent hospitalization or frequent healthcare exposure (e.g., home wound care, patients with cancer); recent antibiotics; or recent infection. We characterized utilization of broad‐spectrum antibiotics (respiratory fluoroquinolone, β‐lactam + macrolide, β‐lactam + doxycycline) versus narrow‐spectrum antibiotics (macrolide, doxycycline) overall and by patient‐ and provider‐level characteristics. Per 2007 IDSA/ATS guidelines, we stratified analyses by otherwise healthy patients and patients with comorbidities (coded for diabetes; chronic heart, liver, or renal disease; etc.).ResultsAmong 263 914 otherwise healthy CAP patients, 35% received broad‐spectrum antibiotics (not recommended); among 37 161 CAP patients with comorbidities, 44% received broad‐spectrum antibiotics (recommended). Ten‐day antibiotic treatment durations were the most common for all antibiotic classes except macrolides. From 2008 to 2019, broad‐spectrum antibiotic use substantially decreased from 45% to 19% in otherwise healthy patients (average annual percentage change [AAPC], −7.5% [95% CI −9.2%, −5.9%]), and from 55% to 29% in patients with comorbidities (AAPC, −5.8% [95% CI −8.8%, −2.6%]). In subgroup analyses, broad‐spectrum antibiotic use varied by age, geographic region, provider specialty, and provider location.ConclusionsReal‐world use of broad‐spectrum antibiotics for outpatient CAP declined over time but remained common, irrespective of comorbidity status. Prolonged duration of therapy was common. Antimicrobial stewardship is needed to aid selection according to comorbidity status and to promote shorter courses.
A comparison of general and special education teachers' attitudes toward evidence‐based practices for students with autism spectrum disorder
Authors: Garman‐McClaine Blaine 
Published: March 2024

AbstractStudents identified with autism spectrum disorder (ASD) benefit from the implementation of evidence‐based practices (EBPs) in all educational settings, including general education classrooms. Research indicates that EBPs are not consistently implemented across educational placements, nor are they always implemented with fidelity. One contextual factor that can influence successful EBP implementation is teacher attitudes toward an EBP. This study examined and compared the attitudes of general education and special education teachers toward EBPs. Study results suggest that special education teachers have more positive attitudes toward EBPs, while general education teachers are more likely to diverge from EBPs to support students with ASD. These findings have implications for improving the implementation of EBPs in both general and special education classrooms for students with disabilities, particularly students with ASD.
Mental health screening in pediatric lower limb deficiency population
Authors: Marshall Emily , Shieh Eileen , Franzone Jeanne M. , Enlow Paul T. 
Published: March 2024

AbstractBackgroundYouth with lower limb deficiency (LLD) may be at increased risk for mental health difficulties. However, guidelines around psychosocial screening are not well established.ObjectiveTo describe the implementation and results of a mental health screening process in a multidisciplinary prosthetics clinic.DesignSurvey.SettingOutpatient specialty care clinic located within a children's hospital.PatientsAll patients ages 0–18 years with LLD seen at a monthly multidisciplinary prosthetics clinic between September 2019 and January 2023 (n = 75).InterventionsNot applicable.Main Outcomes MeasuresQuality of life was measured by the Patient‐Reported Outcomes Measurement Information System (PROMIS) pediatric proxy survey. Psychological functioning was measured using the Strengths and Difficulties Questionnaire (SDQ).ResultsDescriptive statistics were used to determine the proportion of patients who endorsed clinically significant concerns. Of the 75 clinic visits during the study time frame, the psychosocial screeners were completed at 38 (51%). A total of 25 unique patients completed the screeners; 12 patients completed the screener more than once. The most commonly endorsed concerns on the PROMIS were issues with physical mobility (65%) and upper extremity function (40%). The SDQ revealed that a majority (62.5%) of the screened patients had an overall score above the clinical cutoff, indicating psychosocial distress in more than one area. The most commonly reported mental health concern was peer problems (62.5%). Post hoc analysis of repeat screenings indicated that most problems identified during the first screening persisted at follow‐up screenings.ConclusionsClinically significant psychological concerns were common among the sample, indicating the need to address this aspect of patients' well‐being. Preliminary data on repeat screenings suggest that clinically significant concerns may not self‐resolve. Routine psychosocial screening is critical for early identification of mental health problems and timely referral to evidence‐based psychological interventions.
Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT‐cell and T‐cell receptor protein
Authors: Mallis Robert J. , Lee Jonathan J. , Berg Arjen Van den , Brazin Kristine N. , Viennet Thibault , Zmuda Jonathan , Cross Melissa , Radeva Denitsa , Rodriguez‐Mias Ricard , Villén Judit , Gelev Vladimir , Reinherz Ellis L. , Arthanari Haribabu 
Published: March 2024

AbstractProtein nuclear magnetic resonance (NMR) spectroscopy relies on the ability to isotopically label polypeptides, which is achieved through heterologous expression in various host organisms. Most commonly, Escherichia coli is employed by leveraging isotopically substituted ammonium and glucose to uniformly label proteins with 15N and 13C, respectively. Moreover, E. coli can grow and express proteins in uniformly deuterium‐substituted water (D2O), a strategy useful for experiments targeting high molecular weight proteins. Unfortunately, many proteins, particularly those requiring specific posttranslational modifications like disulfide bonding or glycosylation for proper folding and/or function, cannot be readily expressed in their functional forms using E. coli‐based expression systems. One such class of proteins includes T‐cell receptors and their related preT‐cell receptors. In this study, we present an expression system for isotopic labeling of proteins using a nonadherent human embryonic kidney cell line, Expi293F, and a specially designed media. We demonstrate the application of this platform to the β subunit common to both receptors. In addition, we show that this expression system and media can be used to specifically label amino acids Phe, Ile, Val, and Leu in this system, utilizing an amino acid‐specific labeling protocol that allows targeted incorporation at high efficiency without significant isotopic scrambling. We demonstrate that this system can also be used to express proteins with fluorinated amino acids. We were routinely able to obtain an NMR sample with a concentration of 200 μM from 30 mL of culture media, utilizing less than 20 mg of the labeled amino acids.
Stereotactic radiotherapy: An educational narrative review
Authors: Khan Agha Muhammad Hammad , Hashmi Syed Furqan Ahmad , Li Benjamin , Shaukat Fatima , Ahmed Yumna , Alfishawy Mahmoud , Al‐Amri Iqbal , Bashir Rashid , Altaf Furhan , Yilmaz Sercan , Khalid Jamsari , Mandhari Zahid Al , Pervez Nadeem , Rassou Salim Chaib , Mula‐Hussain Layth 
Published: March 2024

AbstractStereotactic radiotherapy is a term collectively used to describe the radiation treatment techniques that allow for the delivery of highly precise ionizing radiation. It is usually a high dose per session in single or few fractions. This treatment approach has been in medical use for over six decades and has primarily evolved in the last two decades. Many patients benefit from this unique non‐conventional radiotherapy approach. Its indications include various malignant, benign and functional problems in cranial and body sites. This technique is not widespread in developing countries compared to developed countries. This work is an educational narrative review for learners in radiation oncology. We aim to share the knowledge of this practice to improve precision radiation oncology globally. This review summarizes the basics of stereotactic radiotherapy, the technical prerequisites, the clinical considerations, the practical recommendations and the learning points from each site‐specific region.
Key roles of insulin receptor InR1 in initiating reproductive diapause in males of the cabbage beetle Colaphellus bowringi (Coleoptera: Chrysomelidae)
Authors: Zhang Yi‐Ke , Zhang Han‐Xue , An Hao‐Min , Wang Kou , Zhu Fen , Liu Wen , Wang Xiao‐Ping 
Published: March 2024

AbstractBACKGROUNDReproductive diapause serves as a valuable strategy enabling insects to survive unfavorable seasonal conditions. However, forcing insects into diapause when the environment is conducive to their well‐being can cause them to miss out on seasonal opportunities for reproduction. This outcome not only reduces insect populations but also minimizes crop losses caused by insect feeding. Therefore, altering the timing of diapause initiation presents a potential strategy for managing pests. In this study, we examined the possible role of the Insulin Receptor 1 (InR1) in controlling reproductive diapause entry in the male cabbage beetle, Colaphellus bowringi.RESULTSCompared to short‐day (SD) conditions, long‐day (LD) conditions led to reproductive diapause of C. bowringi males, characterized by arrested gonad development, increased Triglyceride (TG) accumulation, and upregulated expression of diapause protein 1 and genes associated with lipogenesis and stress tolerance. Upon employing RNA interference to knock down InR1 under SD conditions, males destined for reproduction were compelled into diapause, evidenced by arrested gonadal development, accumulation of TG, and elevated expression of diapause‐related genes. Intriguingly, despite the common association of the absence of juvenile hormone (JH) with reproductive diapause in females, the knockdown of InR1 in males did not significant affect the expression of JH biosynthesis and JH response gene.CONCLUSIONThe study highlight InR1 is a key factor involved in regulating male reproductive diapause in C. bowringi. Consequently, targeting insulin signaling could be a viable approach to perturb diapause timing, offering a promising strategy for managing pests with reproductive diapause capabilities. © 2024 Society of Chemical Industry.
Identification of pine wood nematode (Bursaphelenchus xylophilus) loading response genes in Japanese pine sawyer (Monochamus alternatus) through comparative genomics and transcriptomics
Authors: Zou Xiangying , Jia Jiayu , Zhu Tengfei , Cai Shouping , He Yiman , Su Shunde , Fang Yu , Li Jian , Lin Guifang , Su Jun 
Published: March 2024

AbstractBACKGROUNDPine wood nematode (PWN; Bursaphelenchus xylophilus) is the causative agent of pine wilt disease (PWD), which is considered the most dangerous biohazard to conifer trees globally. The transmission of PWN relies on insect vectors, particularly the Japanese pine sawyer (JPS; Monochamus alternatus). However, the molecular mechanism underlying PWN‐JPS assembly remains largely unknown.RESULTSHere, we found that both geographical and gender could significantly affect the PCA (PWN carrying amount) of JPS; thus, JPS transcriptomes from diverse locations and genders were explored regard to PWN loading. Due to the shortage of genomes, we developed a full‐length reference transcriptome for analyzing next‐generation sequencing data. A comparative genomic study was performed, and 11 248 potential PWN‐carrying associate genes (β) were nominated in JPS by using the reported genomes of PWN and non‐PWN carrier insect species. Then, 151 differentially expressed transcripts (DETs), 28 of them overlapped with β, correlated with the PCA of JPS were nominated by RNA‐Seq, and found that fatty acid β‐oxidation might be the key factor that affected the PCA of JPS. Furthermore, JPS fatty acid β‐oxidation rates were experimentally decreased using the inhibitor Etomoxir, leading to an increased PCA of JPS. Meanwhile, silencing MaCPT1 in JPS by RNA interference led to a decreased fatty acid β‐oxidation rate and increased PCA of JPS.CONCLUSIONSIn conclusion, MaCPT1 was able to decrease the PWN‐JPS assembly formation through the fatty acid β‐oxidation of JPS. These results provide new insights for exploring the impact of PWN invasion on JPS. © 2024 Society of Chemical Industry.
A non‐parametric way to estimate observation errors based on ensemble innovations
Authors: Hu Chih‐Chi , van Leeuwen Peter Jan , Geer Alan J. 
Published: March 2024

AbstractPrevious studies that inferred the observation error statistics from the innovation statistics can only provide the second moment of the error probability density function (pdf). However, the observation errors are sometimes non‐Gaussian, for example, for observation operators with unknown representation errors, or for bounded observations. In this study, we propose a new method, the Deconvolution‐based Observation Error Estimation (DOEE), to infer the full observation error pdf. DOEE does not rely on linear assumptions on the observation operator, the optimality of the data assimilation algorithm, or implicit Gaussian assumptions on the error pdf. The main assumption of DOEE is the availability of an ensemble of background forecasts following the independent and identically distributed (i.i.d.) assumption. We conduct idealized experiments to demonstrate the ability of the DOEE to accurately retrieve a non‐Gaussian (bimodal, skewed, or bounded) observation error pdf. We then apply the DOEE to construct a state‐dependent observation error model for satellite radiances by stratifying the observation errors based on cloud amount. In general, we find that the observation error pdfs in many categories are skewed. By adding a new predictor, total column water vapor (TCWV), into the state‐dependent model, we find that for cloudy pixels, when TCWV is small, the observation error pdfs are quite similar and Gaussian‐like, whereas when TCWV is large, the observation error pdfs differ for different cloud amount, while all of them are positively biased. This result suggests that exploring other predictors, like cloud type, might improve the stratification of the observation error model. We also discuss ways to include a non‐parametric observation error pdf into modern data assimilation schemes, including a consideration of the strong‐constraint 4D‐Var perspective, as well as the implications for other observation types including observations with bounded range.