bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ultrasound-based nomogram model in the assessment of pathological complete response of neoadjuvant chemotherapy in breast cancer
Authors: Liu Jinhui , Leng Xiaoling , Liu Wen , Ma Yuexin , Qiu Lin , Zumureti Tuerhong , Zhang Haijian , Mila Yeerlan 
Published: March 2024

IntroductionWe aim to predict the pathological complete response (pCR) of neoadjuvant chemotherapy (NAC) in breast cancer patients by constructing a Nomogram based on radiomics models, clinicopathological features, and ultrasound features.MethodsUltrasound images of 464 breast cancer patients undergoing NAC were retrospectively analyzed. The patients were further divided into the training cohort and the validation cohort. The radiomics signatures (RS) before NAC treatment (RS1), after 2 cycles of NAC (RS2), and the different signatures between RS2 and RS1 (Delta-RS/RS1) were obtained. LASSO regression and random forest analysis were used for feature screening and model development, respectively. The independent predictors of pCR were screened from clinicopathological features, ultrasound features, and radiomics models by using univariate and multivariate analysis. The Nomogram model was constructed based on the optimal radiomics model and clinicopathological and ultrasound features. The predictive performance was evaluated with the receiver operating characteristic (ROC) curve.ResultsWe found that RS2 had better predictive performance for pCR. In the validation cohort, the area under the ROC curve was 0.817 (95%CI: 0.734-0.900), which was higher than RS1 and Delta-RS/RS1. The Nomogram based on clinicopathological features, ultrasound features, and RS2 could accurately predict the pCR value, and had the area under the ROC curve of 0.897 (95%CI: 0.866-0.929) in the validation cohort. The decision curve analysis showed that the Nomogram model had certain clinical practical value.DiscussionThe Nomogram based on radiomics signatures after two cycles of NAC, and clinicopathological and ultrasound features have good performance in predicting the NAC efficacy of breast cancer.
Intracranial non-germinomatous germ cell tumors in children and adolescents: how can the experience from an uppermiddle-income country contribute to the worldwide effort to improve outcomes?
Authors: Cappellano Andrea M. , Dassi Natalia , Mançano Bruna M. , Epelman Sidnei , Almeida Daniela B. , Cavalheiro Sergio , Dastoli Patricia A. , Alves Maria T. S. , Nicacio Jardel M. , Costa Marcos D. S. , Silva Frederico A. , Aguiar Simone S. , Figueiredo Maria L. , Chen Michael , Silva Nasjla S. , Finlay Jonathan L. 
Published: March 2024

BackgroundNon-germinomatous germ cell tumors (NGGCT) accounts for one third of intracranial GCT. While the germinoma group have an excellent overall survival, the standard of practice for children with NGGCT is still under evaluation.AimsDescribe the results of the of the Brazilian consortium protocol.MethodsSince 2013, 15 patients with a diagnosis of NGGCT by histopathology and/or serum/cerebrospinal fluid (CSF) tumor markers, βHCG &gt;200mlU/ml and/or positive alpha-fetoprotein were treated with neoadjuvant chemotherapy with carboplatin, cyclophosphamide and etoposide followed by ventricular radiotherapy (RTV) of 18Gy with boost (32Gy) to the primary site. Metastatic patients underwent craniospinal irradiation (CSI) and “slow responders” to the four initial cycles of CT, to autologous stem cell transplantation (ASCT) followed by CSI.ResultsMean age, 13.1 years. Thirteen males. Primary sites: pineal (n=12), suprasellar (n=2) and bifocal (n=1). Four patients were metastatic at diagnosis. Eight patients had CSF and/or serum alpha-fetoprotein levels &gt; 1,000ng/ml. Tumor responses after chemotherapy demonstrated complete in six cases and partial in seven, with “second-look” surgery being performed in five cases, and two patients presenting viable lesions being referred to ASCT. The main toxicity observed was hematological grades 3/4. Two patients with metastatic disease, one with Down Syndrome and AFP &gt; 1,000ng/ml and the other with choriocarcinoma and pulmonary metastases, developed progressive disease resulting in death, as well as two other patients without evidence of disease, due to endocrinological disorders. Event-free and overall survival at 2 and 5 years were 80% and 72.7%, respectively, with a mean follow-up of 48 months (range, 7-107).ConclusionsDespite the small number of patients, in our series, treatment with six cycles of chemotherapy and RTV with focal boost for localized disease (n=11) and ACST for identified slow responders (n=2) seem to be effective strategies contributing to the overall effort to improve outcomes of this group of patients.
Biofertilizer and biocontrol properties of Stenotrophomonas maltophilia BCM emphasize its potential application for sustainable agriculture
Authors: Sharma Pinki , Pandey Rajesh , Chauhan Nar Singh 
Published: March 2024

IntroductionMicrobial biofertilizers or biocontrol agents are potential sustainable approaches to overcome the limitations of conventional agricultural practice. However, the limited catalog of microbial candidates for diversified crops creates hurdles in successfully implementing sustainable agriculture for increasing global/local populations. The present study aimed to explore the wheat rhizosphere microbiota for microbial strains with a biofertilizer and biocontrol potential. MethodsUsing a microbial culturing-based approach, 12 unique microbial isolates were identified and screened for biofertilizer/biocontrol potential using genomics and physiological experimentations. Results and discussionMolecular, physiological, and phylogenetic characterization identified Stenotrophomonas maltophilia BCM as a potential microbial candidate for sustainable agriculture. Stenotrophomonas maltophilia BCM was identified as a coccus-shaped gram-negative microbe having optimal growth at 37°C in a partially alkaline environment (pH 8.0) with a proliferation time of ~67 minutes. The stress response physiology of Stenotrophomonas maltophilia BCM indicates its successful survival in dynamic environmental conditions. It significantly increased (P &lt;0.05) the wheat seed germination percentage in the presence of phytopathogens and saline conditions. Genomic characterization decoded the presence of genes involved in plant growth promotion, nutrient assimilation, and antimicrobial activity. Experimental evidence also correlates with genomic insights to explain the potential of Stenotrophomonas maltophilia BCM as a potential biofertilizer and biocontrol agent. With these properties, Stenotrophomonas maltophilia BCM could sustainably promote wheat production to ensure food security for the increasing population, especially in native wheat-consuming areas.
The influence mechanism underlying meaning in life on career adaptability among college students: a chain intermediary model
Authors: Lin Zhengzheng 
Published: March 2024

IntroductionThe coronavirus disease 2019 (COVID-19) has posed a huge challenge to the career situation of college students. This study aimed to understand the mechanism underlying meaning in life on career adaptability among college students during the COVID-19 pandemic.MethodsA quantitative method was adopted. In total, 1,182 college students were surveyed using the Meaning in Life Questionnaire, the Simplified Coping Style Questionnaire, the Adult General Hope Scale, and the Career Adapt-Abilities Scale.ResultsThere was a significant positive correlation between meaning in life, positive coping styles, hope, and career adaptability. Positive coping styles and hope play a separate mediating role and a chain mediating role.DiscussionThe findings of this study emphasize the importance of meaning in life among college students to improve their career adaptability. Furthermore, positive coping styles and increased levels of hope contribute to the development of career adaptability among college students.
Treating depression at home with transcranial direct current stimulation: a feasibility study
Authors: Dragon Katharina , Abdelnaim Mohamed A. , Weber Franziska C. , Heuschert Markus , Englert Leon , Langguth Berthold , Hebel Tobias , Schecklmann Martin 
Published: March 2024

IntroductionTreating major depressive disorder (MDD) with transcranial direct current stimulation (tDCS) devices at home has various logistic advantages compared to tDCS treatment in the clinic. However, preliminary (controlled) studies showed side effects such as skin lesions and difficulties in the implementation of home-based tDCS. Thus, more data are needed regarding the feasibility and possible disadvantages of home-based tDCS.MethodsTen outpatients (23–69 years) with an acute depressive episode were included for this one-arm feasibility study testing home-based tDCS. All patients self-administered prefrontal tDCS (2 mA, 20 min, anodal left, cathodal right) at home on 30 consecutive working days supported by video consultations. Correct implementation of the home-based treatment was analyzed with tDCS recordings. Feasibility was examined by treatment compliance. For additional analyses of effectiveness, three depression scores were used: Hamilton depression rating scale (HDRS-21), Major Depression Inventory (MDI), and the subscale depression of the Depression-Anxiety-Stress Scale (DASS). Furthermore, usability was measured with the user experience questionnaire (UEQ). Tolerability was analyzed by the number of reported adverse events (AEs).ResultsEight patients did not stick to the protocol. AEs were minimal. Four patients responded to the home treatment according to the MDI. Usability was judged positive by the patients.ConclusionsRegular video consultations or other safety concepts are recommended regardless of the number of video sessions actually conducted. Home-based tDCS seems to be safe and handy in our feasibility study, warranting further investigation.
Traditional, cyberbullying, and suicidal behaviors in Argentinian adolescents: the protective role of school, parental, and peer connectedness
Authors: Dadras Omid , Takashi Naoki 
Published: March 2024

IntroductionBullying, both in person and online, is a significant risk factor for a range of negative outcomes including suicidal behaviors among adolescents and it is crucial to explore the protective effects of parental, school, and peer connectedness on suicidal behaviors among victims.MethodsThis study is a secondary analysis of the Argentina Global School-based Student Health Survey (GSHS 2018). Logistic regression analysis, adjusting for age and sex, determines the likelihood of suicidal thoughts and attempts among bullying victims. To explore the modifying effect of school, parental, and peer connectedness on the association between bullying and suicide behaviors, the interaction term was included. Sampling design and weights were applied in all analyses in STATA 17.ResultsThe study included 56,783 students in grades 8-12, with over half being female. Adolescents aged 14-15 exhibited the highest prevalence of bullying, cyberbullying, suicidal thoughts, and attempts, with females displaying a higher prevalence in all measured categories. The study found that adolescents who reported being bullied or cyberbullied demonstrated a significantly higher likelihood of experiencing suicidal thoughts and attempting suicide. Furthermore, protective factors such as school, parental, and peer connectedness were found to play a critical role in mitigating the adverse impacts of bullying and cyberbullying on suicidal thoughts and attempts.ConclusionThe findings underscore the critical prevalence of both bullying and cyberbullying among school-going Argentinian adolescents and their profound association with suicidal behaviors. The study emphasizes the importance of supportive family environments and peer and school connectedness in mitigating the negative effects of bullying and cyberbullying on mental health and suicide risk among adolescents.
Inequality in benefit distribution of reducing the outpatient cost-sharing: evidence from the outpatient pooling scheme in China
Authors: Zhang Tao , Chen Minyan 
Published: March 2024

ObjectiveThe implementation of the outpatient pooling scheme in China has substantially elevated the compensation levels for outpatient expenses. This study aims to assess whether socioeconomically disadvantaged enrollees benefit proportionally compared to their non-disadvantaged counterparts.MethodA cohort comprising 14,581 Urban and Rural Resident Basic Medical Insurance (URRBMI) enrollees and 830 Urban Employee Basic Medical Insurance (UEBMI) enrollees was derived from the China Health and Retirement Longitudinal Study 2018. Outpatient pooling scheme benefits were evaluated based on two metrics: the probability of obtaining benefits and the magnitude of benefits (reimbursement amounts and ratios). Two-part models were employed to adjust outpatient benefits for healthcare needs. Inequality in benefit distribution was assessed using the concentration curve and concentration index (CI).ResultsFollowing adjustments for healthcare needs, the CI for the probability of receiving outpatient benefits for URRBMI and UEBMI enrollees were − 0.0760 and − 0.0514, respectively, indicating an evident pro-poor pattern under the outpatient pooling scheme. However, the CIs of reimbursement amounts (0.0708) and ratio (0.0761) for URRBMI recipients were positive, signifying a discernible pro-rich inequality in the degree of benefits. Conversely, socioeconomically disadvantaged UEBMI enrollees received higher reimbursement amounts and ratios.ConclusionDespite a higher likelihood of socioeconomically disadvantaged groups receiving outpatient benefits, a pro-rich inequality persists in the degree of benefits under the outpatient pooling scheme in China. Comprehensive strategies, including expanding outpatient financial benefits, adopting distinct reimbursement standards, and enhancing the accessibility of outpatient care, need to be implemented to achieve equity in benefits distribution.
The effect of progressive hypoxia on swimming mode and oxygen consumption in the pile perch, Phanerodon vacca
Authors: Frank LeeAnn C. , Prescott Leteisha A. , Scott Molly E. , Domenici Paolo , Johansen Jacob L. , Steffensen John Fleng 
Published: March 2024

IntroductionHypoxia, an increasingly common stressor in coastal environments, lowers the scope for aerobic activity such as sustained swimming. This study examines the effect of self-depleting progressive hypoxia on swimming performance and oxygen consumption of the pile perch, Phanerodon vacca, at their optimal speed (Uopt =29 cm·s−1). P. vacca is a labriform, median-paired fin (MPF) swimmer that exhibits a clear gait transition from primarily oxidative muscle-powered, pectoral fin swimming to primarily anaerobic-powered muscle burst swimming using the caudal fin (BCF) when facing high speeds or low oxygen.Methods and hypothesisWe expected that P. vacca swimming at Uopt would maintain oxygen consumption (ṀO2) alongside decreasing oxygen levels and continue to swim using MPF propulsion until they approached their critical oxygen saturation at their optimal swimming speed (Scrit at Uopt). At this point, we expected a gait transition to occur (i.e., from MPF to BCF propulsion), which is observed by a decrease in pectoral fin beat frequency and an increase in caudal fin or bursting frequency.ResultsIn a closed-system swimming respirometer, P. vacca maintained strictly pectoral fin swimming at a consistent frequency and metabolic rate until reaching a critical oxygen saturation at their Scrit at Uopt of 38.6 ± 1.7% air saturation (O2sat). Below Scrit at Uopt, P. vacca significantly increased pectoral fin beat frequency, followed by a transition to caudal bursting at 33.7% O2sat. Switching to burst swimming allowed P. vacca to swim for 44.4 min beyond Scrit at Uopt until reaching 29.2% O2sat. Excess post-hypoxia oxygen consumption (EPHOC) led to a significant increase in metabolic rate during recovery, which took 1.89 h to return to the routine metabolic rate (RMR).DiscussionTime to return to RMR and EPHOC did not differ when comparing exhaustive exercise and hypoxia exposure, suggesting that this species has an anaerobic energy reserve that does not differ when stressed during hypoxia or exercise. This study demonstrates that in hypoxia, the modulation of swimming mode from pectoral to caudal fin–based locomotion can maintain swimming well below Scrit at Uopt and provides a fundamental understanding of the physiological basis of sustained swimming in hypoxia.
Evaluation of hop test movement quality to enhance return to sport testing. A cross-sectional study
Authors: Weber Melanie , Müller Mirjam , Mathieu-Kälin Moritz , Caminada Sandro , Häberli Marina , Baur Heiner 
Published: March 2024

IntroductionReturn to Sport tests with functional hop tests are often used to decide when a person is ready to return to sport after an anterior cruciate ligament (ACL) injury. Poor movement quality, such as knee valgus, hip adduction and hip internal rotation is considered a risk factor for ACL injury. However, it is unclear whether existing tests adequately cover the aspect of movement quality. This study aims to investigate whether there is a relationship between the calculated limb symmetry index (LSI) of hop tests as an indication of performance and the total score of the “Quality First” assessment (movement quality). The second aim is to examine the reliability of the newly developed “Quality First” assessment for evaluating movement quality in hop tests.MethodsThe cross-sectional study recruited 34 patients with an ACL reconstruction. The vertical hop, single-leg hop for distance, and side hop tests were performed and recorded. The video recordings were assessed using the “Quality First” assessment. The Spearman correlation coefficient was calculated using the LSI and the “Quality First” total score. Intraclass correlation coefficients (ICC) and standard error of measurements (SEM) were used to calculate intra- and interrater reliability. In addition, the minimal detectable change (MDC) was determined.ResultsThe correlation test between the LSI and the “Quality First” total score showed no correlation for all three jumps (r = −0.1–0.02/p-value = 0.65–0.93). The interrater reliability of the “Quality First” assessment showed fair to good reliability (ICC2: 0.45–0.60), with SEM ranging from 1.46 to 1.73 and the MDC from 4.06 to 4.8. Intrarater reliability was good to excellent (ICC3: 0.73–0.85), with SEM values ranging from 0.89 to 1.09 and the MDC from 2.47 to 3.01.ConclusionThe quality of movement, measured with the “Quality First” assessment, indicated no correlation with the calculated LSI from jump performance, therefore movement quality should also be examined in Return to Sport tests. The “Quality First” assessment shows fair to good reliability when used by different raters. When used multiple times by the same rater, the assessment has good to excellent reliability.
Overexpression of HbGRF4 or HbGRF4-HbGIF1 Chimera Improves the Efficiency of Somatic Embryogenesis in Hevea brasiliensis
Authors: Luo Xiaomei , Zhang Yi , Zhou Miaomiao , Liu Kaiye , Zhang Shengmin , Ye De , Tang Chaorong , Cao Jie 
Published: March 2024

Transgenic technology is a crucial tool for gene functional analysis and targeted genetic modification in the para rubber tree (Hevea brasiliensis). However, low efficiency of plant regeneration via somatic embryogenesis remains a bottleneck of successful genetic transformation in H. brasiliensis. Enhancing expression of GROWTH-REGULATING FACTOR 4 (GRF4)-GRF-INTERACTING FACTOR 1 (GIF1) has been reported to significantly improve shoot and embryo regeneration in multiple crops. Here, we identified endogenous HbGRF4 and HbGIF1 from the rubber clone Reyan7-33-97, the expressions of which dramatically increased along with somatic embryo (SE) production. Intriguingly, overexpression of HbGRF4 or HbGRF4-HbGIF1 markedly enhanced the efficiency of embryogenesis in two H. brasiliensis callus lines with contrasting rates of SE production. Transcriptional profiling revealed that the genes involved in jasmonic acid response were up-regulated, whereas those in ethylene biosynthesis and response as well as the S-adenosylmethionine-dependent methyltransferase activity were down-regulated in HbGRF4- and HbGRF4-HbGIF1-overexpressing H. brasiliensis embryos. These findings open up a new avenue for improving SE production in rubber tree, and help to unravel the underlying mechanisms of HbGRF4-enhanced somatic embryogenesis.
Polymer-Clay Nanocomposites for the Uptake of Hazardous Anions
Authors: Zhang Huaibin , Huang Wenyan , Komarneni Sridhar 
Published: March 2024

Polymer intercalated clay nanocomposites were prepared from various montmorillonites (Mt) and a polymer, polydiallyldimethylammonim (PDDA) chloride. X-ray diffraction (XRD) analysis of the above polymer intercalated nanocomposites showed either no crystalline peaks or very broad peaks with the intercalation of PDDA polymer in the interlayers, probably as a result of exfoliation of the clay layers. Infrared spectroscopy revealed the presence of PDDA in all the clay nanocomposite materials. The maximum adsorption capacities of nitrate, perchlorate, and chromate by one of the polymer intercalated nanocomposite materials prepared from montmorillonite, Kunipea were 0.40 mmol·g−1, 0.44 mmol·g−1 and 0.299 mmol·g−1, respectively. The other two polymer intercalated nanocomposites prepared with montmorillonites from Wyoming and China showed very good adsorption capacities for perchlorate but somewhat lower uptake capacities for chromate and nitrate compared to the nanocomposite prepared from montmorillonite from Kunipea. The uptake of nitrate, perchlorate and chromate by the polymer intercalated nanocomposites could be well described using the Freundlich isotherm while their uptake kinetics fitted well to the pseudo-second-order model. The uptake kinetics of nitrate, perchlorate, and chromate were found to be fast as equilibrium was reached within 4 h. Moreover, the uptakes of chromate by polymer intercalated nanocomposites were found to be highly selective in the presence of Cl−, SO42− and CO32−, the most abundant naturally occurring anions.