bluuebunny/crossref_metadata_2025_split huggingface dataset:
eSports in higher vocational education programs: feasibility and prospects
Authors: Lazarev E. M. , Koshel V. A. 
Published: April 2024

Introduction. The main idea of the article is to actualize the formation of professional competencies of specialists in the sphere of cybersport in the system of higher education.Purpose setting. In the 21st century, due to the rapid development of technology, a new type of leisure activities – cybersport – has appeared, which has given the young generation a completely new way of self-realization and acquiring unique competencies. The research is undertaken to investigate the feasibility of including cybersport in the system of higher education, both as a separate program and its integration into other profiles of education.Methodology and methods of the study. The methodological approach of the research consists in the empirical examination of the relevance of competences in cybersport.Results. This paper considers the positive prospects for the introduction of cybersport direction in the education system from the point of view of the development of human potential of the Russian society. Conclusion. The undertaken research confirms the increasing relevance of the formation of competencies of professionals engaged in the sphere of cybersport.
Unusual Presentation of Hip Pain in a Pregnant Woman Due to Bilateral Cervical Neck Stress Fractures
Authors: Vinograd Ofir , Shohat Noam , Essa Ahmad 
Published: April 2024

Case:
We present an unusual case of bilateral femoral neck fatigue fractures in a 28-year-old pregnant woman at the 18th week of gestation successfully treated through operative intervention involving consecutive total hip arthroplasty and internal fixation within the same procedure, resulting in favorable clinical outcomes.

Conclusion:
Current clinical practices suggest that a restricted use of plain radiographs, even those involving the pelvis in pregnant women carries a minimal risk to the fetus and is not contraindicated. Magnetic resonance imaging proved valuable for differential diagnosis, contrasting with sonography.
Arthroscopic Femoral Head Allograft With Proximal Femoral/Periacetabular Osteotomies for Sequelae of Perthes
Authors: Girardi Nicholas G. , Kraeutler Matthew J. , Lee Jessica H. , Merkle Alex N. , Mei-Dan Omer 
Published: April 2024

Case:
We describe the unique case of a 20-year-old man with a history of Legg-Calve-Perthes disease, hip dysplasia, and osteochondral fragmentation of the medial femoral head. We performed arthroscopic femoroplasty and femoral head allografting, followed by a valgus-producing derotational femoral osteotomy (DFO) and periacetabular osteotomy (PAO). At 1-year follow-up, the patient achieved osseous union and complete femoral head healing with return to his active hobbies.

Conclusion:
We describe the successful utilization of arthroscopic allografting for medial femoral head osteochondral fragmentation. To our knowledge, this is the first report on femoral head arthroscopic allografting before DFO and PAO.
Thrombosed Persistent Median Artery with Coexisting Bifid Median Nerve in a Robotic Arthroplasty Surgeon
Authors: Eachempati Krishna Kiran , Parameswaran Apurve , Yadav Vikas K. , Kumar Roshna Prem , Ponnala Vinay Kishore , Apsingi Sunil 
Published: April 2024

Case:
A 47-year-old orthopaedic surgeon presented with acute volar left wrist pain. He performed over 250 robot-assisted knee arthroplasties each year. Color Doppler evaluation revealed bilateral persistent median arteries and bifid median nerves, with focal occlusive thrombosis of the left median artery. He was advised rest and oral aspirin. He could return to his professional activities after 1 month. He had no recurrence of symptoms at 1 year of follow-up.

Conclusion:
Orthopaedic surgeons use vibrating hand tools on a daily basis. The possibility of hand-arm vibration syndrome must be considered in the differential diagnosis of wrist pain among orthopaedic surgeons.
LOCOMOTION TRACES EMPLACED BY MODERN STALKLESS COMATULID CRINOIDS (FEATHERSTARS)
Authors: MYERS REED A. , FURLONG CAROLYN M. , GINGRAS MURRAY K. , ZONNEVELD JOHN-PAUL 
Published: April 2024

Abstract
Modern crinoids have the ability to use their arms to crawl along the sea floor and some are capable of swimming short distances. The first and only evidence of crinoid locomotion reported from the rock record was described from the Middle Jurassic of the Cabeço da Ladeira Lagerstätte (Portugal) resulting in description of the ichnotaxon Krinodromos bentou. Although the mechanics of crinoid movement are well documented the morphological ranges of crinoid motility tracks are unknown. This study uses observations of crinoid movement and their effects on sediment using modern comatulid crinoids to propose possible trace fossil morphologies. Using 20 experimental trials supported by photography, video analyses, 3D orthogrammetry and resin casting, the morphological ranges of crinoid motility tracks are included in five distinct morphologies attributed to ambling, crawling, walking, running, and landing/taking-off traces, the latter of which are emplaced before and after swimming.
Traces produced by ambling occur as epigenic hook-shaped grooves. Crawling traces comprise closely spaced hook-shaped grooves and ridges preserved in concave and convex epirelief. Walking traces consist of semi-bilaterally symmetrical collections of three or more grooves, and associated ridges, preserved in convex and concave epirelief.
Running traces consist of semi-bilaterally symmetrical collections of one to three straight to semi-sinusoidal grooves and associated ridges preserved in concave and convex epirelief. Landing/taking-off traces are mounded features preserved in convex epirelief, with grooves radiating from the center. The five trace types described in this paper provide insight into morphological features that can be associated with modern crinoid activities and used to identify crinoid trace fossils, which are rarely reported, in the rock record.
Evolution of Trochamminoids (Trochospiral Organic-Cemented Agglutinated Foraminifera): Examples from the Lower Permian of Western Australia
Authors: Tremblin Clément Mathieu , Haig David William 
Published: April 2024

Abstract
Trochamminids are the oldest trochospiral group of foraminifera. An exceptionally well-preserved assemblage, found in the Lower Permian (Sakmarian, ∼294–290 Ma) of Western Australia, includes Trochammina geoffplayfordi n. sp., Trochammina gloveri n. sp., Trochamminopsis teicherti n. sp., and Tritaxis crespinae n. sp. Verispira holmesorum n. sp. seems related to broader Trochamminoidea. These represent the oldest known well-preserved representatives of the superfamily. By the Sakmarian, trochamminids, remarkably like modern species, had developed in a shallow-water interior sea with muddy substrate; some may have lived in the flocculent surface layer of the mud, and some were epibionts. No potential trochospiral ancestor is known among calcareous foraminifera of the Late Paleozoic. Triassic Duostomina seems to be the oldest calcareous taxa with simple trochospiral coiling (also having an inner organic lining). Molecular analyses of modern species suggest that morphotypes like the Permian Trochammina lie at some genetic distance from Trochammina inflata (type species of the genus).
On The Curious Illustration of The Foraminifer Peneroplis Planatus In Haeckel'S Kunstformen Der Natur (1899–1904)
Authors: Dolan John R. 
Published: April 2024

Abstract
In Ernst Haeckel’s classic book Kunstsformen der Natur (Art Forms in Nature), forams are prominent; they occupy three of the 100 plates. In one plate, the centerpiece is Peneroplis planatus, shown with extended rhizopods, and organisms from the plankton. It is a very curious illustration as it is the only foram shown living and one of only two organisms in all of Kunstsformen der Natur pictured with possible prey. Here I show that the apparent planktonic prey of P. planatus closely resemble the prey items shown in Haeckel's earlier illustrations of his supposedly primitive life forms Protogenes primordialis and Protomyxa aurantiaca in the 1860s. These forms, now considered dubious, were described as possibly naked forams by Claus (1872), a diagnosis repeated by Brady (1884) in his HMS Challenger report, a source of many illustrations in Haeckel's foram plates. I speculate that Haeckel's depiction of P. planatus, shown much like his primitive forms, was a discrete nod of agreement with the diagnoses of Claus (1872). Examples of Haeckel's stylizations of the morphology of forams in his plates are also shown in support of the notion that Haeckel exercised artistic liberty in his depictions of forams.
StratoMod: Predicting sequencing and variant calling errors with interpretable machine learning
Authors: Dwarshuis Nathan , Tonner Peter , Olson Nathanael , Sedlazeck Fritz , Wagner Justin , Zook Justin 
Published: April 2024

Abstract

Repetitive structures in the genome often lead to difficulty in accurately characterizing variation across a variety of sequencing technologies and variant detection methods. To address this, the Genome in a Bottle consortium maintains “stratification BED files” for error analysis in “difficult” regions such as homopolymers and segmental duplications. However, this strategy represents genomic context in discrete bins, which sacrifices precision when quantifying difficulty; this could be improved using a data-driven model. To this end, we developed StratoMod, which uses an interpretable machine learning classifier to predict variant calling errors using features derived from genomic data. StratoMod identified distinct associations with errors for A/T vs. G/C homopolymer lengths, and quantified sources of error for a new sequencing technology. We also demonstrated that the model could predict clinically-relevant variants that may be missed by certain methods, using DeepVariant calls from Illumina as an example. From this we also produced a resource of difficult-to-map genes with challenging variants and large challenging INDELs. In each use-case, the interpretability of StratoMod enables one to understand how each feature contributed to a prediction. We anticipate this will be useful for method developers and clinicians who desire a quantitative understanding of sources of variant-calling errors.
Technology-Driven Transformations in Consumer Buying Behavior: Implications for Marketers
Authors: . Sreeanandan , A Baranipriya , R Roshni P 
Published: April 2024

Abstract

Amid the fast-evolving landscape, characterized by the far-reaching impact of the Internet and rapid technological progress, consumer behaviors and needs are undergoing a significant transformation (Karenhka, 2013). This is particularly pronounced in India, with over 50% of the population aged under 25 and 65% under 35 (National Statistical Commission, 2017). The younger generation is growing up in a world saturated with technology, influenced by widespread Internet access, data abundance, and ongoing mobile innovations (Han Wai et al., 2016). Our research paper thoroughly investigates the impact of technological advancements on the diverse stages of the consumer buying process, including need recognition, information search, alternative evaluation, decision-making, and post-purchase behaviors. Based on the comprehensive reviews of literatures, empirical past analysis, and expert talks, the present study is rigorously analyzed, validated and formulated four hypotheses in different dimensions of consumer behavior. The research highlights the substantial influence of technological innovations on the consumer purchasing journey, emphasizing the importance for marketers to incorporate key disruptive technologies into their marketing strategies.
JEL Code: D12, O33, M31
WITHDRAWN: Post Fever Retinitis - Experience From Tertiary Eye Care Hospital in Central India
Authors: PALIWAL SONAL PALIWAL , prerna prerena upadhyaya 
Published: April 2024

Abstract
The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Cross-Immunity as a Potential Explanation for the Smoker's Paradox in COVID-19: Evidence from a Systematic Review and Meta-Analysis
Authors: Gonzalez-Rubio Jesus , Navarro-López Juan D. , Jiménez-Díaz Lydia , Najera Alberto 
Published: April 2024

Abstract

Introduction: Recent evidence shows that a cross-immunity reaction exists between the T-cells associated with common cold coronaviruses (229E, NL63, OC43, HKU1) and SARS-CoV-2, the causal agent of COVID-19. It is also known that the prevalence of smokers among patients admitted to hospital for COVID-19 is lower than expected according to the corresponding country’s smoking prevalence, which is known as smoker’s paradox in COVID-19. No clear consensus to explain it has yet been reached. Nonetheless, very few works have studied the prevalence of smokers in those infected by common cold coronaviruses, and its relation to COVID-19 has not been investigated.
Methods: We performed a systematic review and meta-analysis to study the prevalence of smokers among patients infected by common cold coronaviruses, and to compare them to the corresponding country’s smoking prevalence.
Results: The results show that smoking prevalence is higher among those patients infected by these coronaviruses than in the general population (OR = 1.37, 95%CI: 0.81-2.33). A study was separately done for the four coronavirus types, and the prevalence of smokers was higher in three of the four than that corresponding to country, gender and study year: OC43 (OR = 1.93, 95%CI: 0.64-5.82); HKU1 (OR = 3.62, 95%CI: 1.21-10.85); NL63 (OR = 1.93, 95%CI: 0.64-5.82); 229E (OR = 0.97, 95%CI: 0.50-1.90).
Conclusions: Our data suggest that COVID-19 might be less prevalent among smokers due to greater cross-inmmunity from a larger number or more recent infections by common cold coronaviruses than the non-smoking population, which would explain smoker’s paradox in COVID-19
Circulating Inflammatory Biomarkers mediates the causal effect of Aging on Female Pelvic Organ Prolapse: Mendelian Randomization Analysis
Authors: Huang Xiaoyu , Xiao Ya , Chen Mao , Zhu Fangyi , Chen Liying , Tian Xiaoyu , Hong Li 
Published: April 2024

Abstract

Aims
Female pelvic organ prolapse (POP) is a disease associated with aging and inflammation, though it is not determined that aging and inflammation are causative factors. The purpose of this study was to evaluate the causal effects of aging and inflammatory factors on female pelvic organ prolapse (POP).
Methods
Significant genetic variables were evaluated by assessing genome-wide association study (GWAS) data for POP and 5 age biomarkers (GrimAge, HorvathAge, HannumAge, PhenoAge, and leukocyte telomere length). Initially, a bidirectional MR analysis was conducted utilizing a random-effects inverse variance-weighted IVW method to elucidate the causal association. Other MR methods and sensitivity analyses were also used. Then, we also used a two-step MR analysis to analyze the mediating effect of six circulating inflammatory biomarkers in the causal relationship between age and POP. Finally, two-sample MR analysis was also used to investigate the effects of 190 inflammatory cytokines on POP risk.
Results
Shorter leukocyte telomere length (LTL), rather than epigenetic clocks is genetically predicted to increase the risk of POP. MR analysis showed that shorter LTL is associated with higher leukocyte count, which can lead to POP. A significant causal association was found between 44 circulating inflammatory cytokines and POP risk. After adjusting for multiple tests, CXCL14, IL17A, IL18, IL6, TNFRSF10B, and TNFSF9 remained statistically significant.
Conclusions
Our findings provide that leukocyte count mediates the potential genetic causal impact of shorter LTL on the development of POP. Inflammatory cytokines might to be considered as potential targets for intervention in POP.
Investigating Medical Functionality of Chitosan-ZnO Nanoparticles Modified Fabric with Enhanced Properties
Authors: Islam Redwanul , Saha Suprio Shantanu , Raen Reana 
Published: April 2024

Abstract

This study delves into exploring the medical potentials of Chitosan-ZnO nanoparticles integrated onto jute cotton fabric. Employing a sustainable approach, ZnO nanoparticles and chitosan were synthesized through eco-friendly methods, utilizing Nigella sativa seed extract and shrimp shell, respectively. After that, these components were applied to jute cotton fabric using the dip-pad-dry-cure technique, together with a 2-weight percent acrylic binder. During the coating procedure, chitosan and ZnO nanoparticles were also mixed together. The structural, microstructural, and chemical characteristics of the coated samples were clarified by characterization using FTIR, UV-vis spectroscopy, XRD, and SEM. Antifungal activities against C. albicans and A. fumigates, as well as antibacterial characteristics against Gram-positive (S. aureus, B. subtilis) and Gram-negative (E. coli, P. aeruginosa) bacteria, were all evaluated, along with UV protection. Mechanical properties of the modified fabric were also scrutinized. Results showcased enhanced antibacterial and antifungal activities, superior UV protection, and improved mechanical strength compared to untreated fabric. The findings underscore the potential of Chitosan-ZnO nanoparticle-modified jute cotton fabric as a promising biomedical textile due to its inherent antibacterial and antifungal attributes. This research not only highlights the development of eco-friendly synthesis methods but also underscores the multifunctional capabilities of the modified fabric, offering significant implications for medical applications.
Priorities of Patients with Spinal Cord Injury in Different Aspects of Rehabilitation in Turkiye
Authors: Atasoy Mücahit , Kalaoglu Eser , Bucak Ömer , Coşkun Evrim 
Published: April 2024

Abstract

This study aimed to understand the needs and expectations of individuals with disabilities caused by spinal cord injuries who require long-term rehabilitation from a rehabilitation hospital. The cross-sectional clinical study was conducted, which included individuals over the age of 18 with spinal cord injuries who had previously been hospitalized in a rehabilitation hospital. The 16-question survey, titled "What should a rehabilitation hospital be like according to patients with spinal cord injuries," was applied to individuals hospitalized in the inpatient service of Çam Sakura City Hospital. It was also given to spinal cord injured people reached through social media. The participants' demographic data was recorded, and the survey was completed by 120 participants, comprising 70 males and 50 females. The mean age was 37.47 ± 11.63 years, with 79 participants being married and 41 being single. Twenty-five participants had graduated from at least one university. The time since the spinal cord injury was less than two years for 20 individuals and more than two years for 100 individuals. The results showed that robotic rehabilitation and psychological support were the most requested rehabilitation elements, while interest in sexual rehabilitation was less than other rehabilitation elements. Furthermore, in the correlation analysis, elderly participants indicated that there should be more specialized services and outpatient clinics. This study highlights the importance of considering the needs and wishes of patients when planning and operating a rehabilitation center. The study clarifies that patients' needs for specialized services and robotic rehabilitation were striking. Additionally, the significance and necessity of sexual rehabilitation should be conveyed to patients.
The selective effect of Ivermectin on different human coronaviruses; in-vitro study
Authors: Shahin Amina Dakeh , Atari Nofar , Meningher Tal , Erster Oran , Avni Dror , Schwartz Eli , Mandelboim Michal 
Published: April 2024

Abstract

Background: The outbreak of coronavirus disease COVID-19, caused by Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2) has become an urgent public health concern worldwide. Although several clinical trials have pointed to new drugs with some anti-COVID-19 activity, we are far from having a safe and effective drug. In this study, we tested the effect of ivermectin on several coronaviruses (serotypes), including variants of SARS-CoV-2.
Methods: The effect of ivermectin was tested on cells infected with four different coronaviruses: NL63 (Alphacoronavirus genus.), OC43, SARS-CoV-2, and Omicron (all Betacoronavirus genus). Two hours post-infection, different doses of ivermectin were added to the cell culture.
Results: There was no effect of even a high dose of ivermectin on NL63, however, we found a significant effect on OC43 PFU with a 40% inhibition at a dose of 5M. The impact of ivermectin on SARS-CoV-2 and on its Omicron variant was much more pronounced and at a dose of 5M there was inhibition of 90% and 95% respectively.
Discussion: Although coronaviruses have been recognized as human pathogens for more than 50 years, no effective treatment strategy exists. Our current study did not demonstrate any effect of ivermectin on Alphacoronavirus but it had a specific impact on the Betacoronavirus genus with a mild impact on OC43 and a decidedly pronounced effect on SARS-CoV-2 including its Omicron variant. Ivermectin should be further studied as a single agent or as part of combined treatment against Coronaviruses.
Red Blood Cell Distribution Width-to-Albumin Ratio as Novel Biomarker Predicting Mortality in Cardiovascular Disease: A Systematic Review and Dose-Response Meta-Analysis
Authors: Arba Ihsan Fachry , Multazam Chaq El Chaq Zamzam , Widiarti Wynne , Siahaan Paulus Parholong , Oktaviono Yudi Her , Setyobudi David , Saputra Pandit Bagus Tri , Lamara Ariikah Dyah , Arnindita Jannatin Nisa’ 
Published: April 2024

Abstract
Red blood cell distribution width (RDW) and albumin separately have been used as mortality predictors for people with cardiovascular disease (CVD). This study aims to explore whether the RDW-to-albumin ratio (RAR) could provide a better prognostication in the CVD population. A systematic search of suitable studies was conducted in PubMed, Web of Science, Scopus, and ProQuest until February 1, 2024. Mortality and length of stay outcomes of the highest vs lowest RAR tertile were pooled using hazard ratio (HR) and standardized mean difference (SMD), respectively. Additionally, a dose-response meta-analysis was performed. Publication bias, subgroup, and sensitivity analyses were conducted to address the causes of heterogeneity. Sixteen studies with 30,933 participants were included in the meta-analysis. Pooled results showed that patients with higher RAR faced a significantly higher risk of mortality (HR 1.88, 95%CI 1.59–2.23). Nonlinearity was observed in the dose-response relationship. Using a reference value of 3 ml/g, each 1 ml/g increase in RAR corresponded to a 27% rise in the mortality HR (HR 1.27, 95%CI 1.16–1.39). Our study demonstrated that elevated RAR values were significantly associated with higher mortality in CVD and exhibited a positive dose-response relationship, suggesting its potential as a novel prognostic biomarker for CVD.