bluuebunny/crossref_metadata_2025_split huggingface dataset:
High dimensional model representation for piece‐wise continuous function approximation
Authors: Chowdhury Rajib , Rao B. N. , Prasad A. Meher 
Published: September 2007

AbstractHigh dimensional model representation (HDMR) approximates multivariate functions in such a way that the component functions of the approximation are ordered starting from a constant and gradually approaching to multivariance as we proceed along the terms like first‐order, second‐order and so on. Until now HDMR applications include construction of a computational model directly from laboratory/field data, creating an efficient fully equivalent operational model to replace an existing time‐consuming mathematical model, identification of key model variables, global uncertainty assessments, efficient quantitative risk assessments, etc. In this paper, the potential of HDMR for tackling univariate and multivariate piece‐wise continuous functions is explored. Eight numerical examples are presented to illustrate the performance of HDMR for approximating a univariate or a multivariate piece‐wise continuous function with an equivalent continuous function. Copyright © 2007 John Wiley & Sons, Ltd.
The JAK/STAT pathway regulates proximo‐distal patterning in Drosophila
Authors: Ayala‐Camargo Aidee , Ekas Laura A. , Flaherty Maria Sol , Baeg Gyeong‐Hun , Bach Erika A. 
Published: September 2007

Abstractunpaired, wingless, and decapentaplegic have independent expression domains. unpaired (upd) (green), wingless (Wg) (red) and decapentaplegic (dpp) (blue) do not overlap in a Drosophila third instar antennal disc. In this issue, Ayala‐Camargo et al. show that these factors mutually repress each other's expression and that this repression is critical for the formation of a single proximo‐distal axis per leg or antenna. upd‐Gal4, UAS‐gfp enhancer trap (green); Wg protein (red) and dpp‐lacZ (anti Beta‐galactosidase) (blue). Anterior is to the left and dorsal is up. See Ayala‐Camargo et al., Developmental Dynamics 236:2721‐2730. © 2007 Wiley‐Liss, Inc.
Synthesis and Structure of Tetrameric Gallium(I) Amides
Authors: Seifert Annekathrin , Linti Gerald 
Published: September 2007

AbstractThe amino substituted gallatetrahedranes described herein, Ga4(tmp)4 [tmp = 2,2,6,6‐(tetramethylpiperidino)] and Ga4[N(SiMe3)dipp]4 (dipp = 2,6‐diisopropylphenyl), are the first oligomeric gallium(I) amides to be reported. These compounds are formed in a facile manner from “GaI”. A new hexagallane with an unusual structure is also described. The clusters were characterized by NMR and UV/Vis spectroscopy, single‐crystal X‐ray crystallography, and DFT calculations.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Computational fluid dynamics of stented intracranial aneurysms using adaptive embedded unstructured grids
Authors: Appanaboyina S. , Mut F. , Löhner R. , Putman C. M. , Cebral J. R. 
Published: September 2007

AbstractRecently, there has been increased interest in the use of stents as flow diverters in the endovascular treatment of cerebral aneurysms as an alternative to surgical clipping or endovascular embolization with coils. The aim of aneurysm stenting is to block the flow into the aneurysm in order to clot the blood inside the aneurysm and effectively isolate it from the circulation and prevent bleeding from the aneurysm. A hybrid meshing approach that combines body‐fitted grids for the vessels and adaptive embedded grids for the stents is proposed and analyzed. This strategy simplifies considerably the geometry modeling problem and allows accurate patient‐specific hemodynamic simulations with endovascular devices. This approach is compared with the traditional body‐fitted approach in the case of the flow around a circular cylinder at representative Reynolds number and an idealized aneurysm model with a stent. A novel technique to map different stent designs to a given patient‐specific anatomical model is presented. The methodology is demonstrated on a patient‐specific hemodynamic model of an aneurysm of the internal carotid artery constructed from a 3D rotational angiogram and stented with two different stent designs. The results show that the methodology can be successfully used to model patient‐specific anatomies with different stents thereby making it possible to explore different stent designs. Copyright © 2007 John Wiley & Sons, Ltd.
Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells
Authors: Jung C. G. , Kim H. J. , Miron V. E. , Cook S. , Kennedy T. E. , Foster C. A. , Antel J. P. , Soliven B. 
Published: September 2007

AbstractFingolimod (FTY720) and its phosphorylated form FTY720P are modulators of sphingosine‐1‐phosphate (S1P) receptors, which are G‐protein coupled receptors linked to cell migration and vascular maturation. The efficacy of FTY720 in autoimmune diseases such as multiple sclerosis and its animal models has been attributed to its inhibition of lymphocyte trafficking to target organs. In this study, we examined the role of S1P receptors in cultured rat oligodendrocytes (OLGs) and OLG progenitor cells (OPCs) using the active phosphorylated form of FTY720. We found that (1) FTY720P improves the survival of neonatal rat OLGs during serum withdrawal, which is associated with the phosphorylation of extracellular signal regulated kinases (ERK1/2) and Akt; (2) FTY720P regulates OPC differentiation into OLGs in a concentration‐dependent manner; and (3) S1P receptors are differentially modulated by platelet‐derived growth factor (PDGF) resulting in downregulation of S1P5 and upregulation of S1P1 in OPCs. In addition, siRNA studies revealed that S1P1 participates in PDGF‐induced OPC mitogenesis. We conclude that S1P1 and S1P5 serve different functions during oligodendroglial development, and possibly during remyelination. © 2007 Wiley‐Liss, Inc.
R‐CHOP‐14 in patients with diffuse large B‐cell lymphoma younger than 70 years: a multicentre, prospective study
Authors: Rueda Antonio , Sabin Pilar , Rifá Juli , Llanos Marta , Gómez‐Codina José , Lobo Francisco , García Ramón , Herrero Joaquin , Provencio Mariano , Jara Carlos 
Published: September 2007

AbstractSeveral studies have shown that adding rituximab to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) or reducing the interval between chemotherapy cycles from 3 weeks to 2 weeks improves survival in patients with diffuse large B‐cell lymphoma (DLBCL). These studies prompted our group (GOTEL) to evaluate prospectively in a pilot study the feasibility and efficacy of R‐CHOP‐14 in patients with DLBCL. Patients (<70 years) with stage II bulky or stage III or IV DLBCL and no significant comorbidities were included in the study. Rituximab was administered on day 1 before chemotherapy. R‐CHOP was given every 14 days. All patients received filgrastim (5 µg/kg) from days 4 to 10. From May 2002 to August 2004, 80 patients were recruited. Median age was 53 years and 58 patients were <60 years. According to the age‐adjusted international prognostic index (aaIPI), 13 patients (16%) had low‐risk disease, 31 (39%) low‐to‐intermediate risk, 27 (34%) high‐to‐intermediate risk and 9 (11%) high‐risk disease. Grade 3–4 neutropenia was observed in 15 patients (17.5%) and grade 3–4 infections in 13 patients (16%). After therapy, 58 patients (73%) achieved CR‐CRu (95% CI: 55–90%). With a median follow‐up of 26 months, progression‐free survival (PFS) and overall survival (OS) at 30 months were 72% and 86%, respectively. Administration of R‐CHOP‐14 is feasible and effective in patients <70 years. Copyright © 2007 John Wiley & Sons, Ltd.
Genesis of arsenic in groundwater of North Bengal Plain using PCA: A case study of English Bazar Block, Malda District, West Bengal, India
Authors: Sikdar P. K. , Chakraborty Surajit 
Published: September 2007

AbstractThe study area is located on the western part of the alluvium‐filled gap between the Rajmahal hills on the west and the Garo hills on the east. Groundwater occurs under unconfined condition in a thick zone of saturation within the Quaternary alluvial sediments. Three hydrochemical facies with distinct characteristics have been identified which are dominated in general by alkaline earths and weak acids. The major‐ion chemistry of the area is controlled by weathering of silicate minerals, rainfall recharge, ion‐exchange processes and anthropogenic activities such as irrigation return flow and the application of inorganic fertilizers and pesticides. A stoichiometric approach suggests that mineral dissolution and anthropogenic activities contribute 79% and 21% of the total cations dissolved in groundwater. Principal component analysis (PCA) of 42 groundwater samples using 13 chemical parameters indicates that the combined processes of recharge of groundwater from rainfall, sediment water interaction, groundwater flow, infiltration of irrigation return water (which is arsenic rich due to the use of arsenic‐bearing pesticides, wood preservatives, etc. and the pumping of arsenic‐rich groundwater for agriculture purpose), oxidation of natural or anthropogenic organic matter and the reductive dissolution of ferric iron and manganese oxides play a key role in the evolution of groundwater in the study area. Factor 2 scores, associated with the infiltration of irrigation return water and spatial distribution of arsenic concentration reveal that the groundwater of the municipal area will not be affected by arsenic in the future in spite of heavy groundwater abstraction. Another PCA with geologic, geomorphic, anthropogenic, geochemical and landuse factors indicates that arsenic concentration in groundwater increases with increasing area of mango orchards, sand lithofacies and nitrate and decreases with increasing distance of paleochannel from the monitored well and depth of bore wells. High loading on nitrate may be attributed to the use of fertilizer, pesticides, etc. in mango orchards and agricultural land. High loadings on logpCO2, mango orchards (with negative sign) and phosphate (with positive sign) indicate that mango orchards provide the organic waste material which is decomposed to form organic carbon. The organic carbon undergoes oxidative carbon degeneration by different oxidants and increases the concentration of CO2in the aquifer. The reducing condition thus developed in the aquifer helps to dissolve the arsenic adsorbed on iron hydroxide or oxy‐hydroxide coated margins of sand, iron rich heavy mineral grain margins, clay minerals and Fe–Mn concretions present in the aquifer matrix. Copyright © 2007 John Wiley & Sons, Ltd.
Does the Chinese interest rate follow the US interest rate?
Authors: Cheung Yin‐Wong , Tam Dickson C. , Yiu Matthew S. 
Published: September 2007

AbstractOne argument for floating the Chinese renminbi (RMB) is to insulate China's monetary policy from the US effect. However, we note that both theoretical considerations and empirical results do not offer a definite answer on the link between exchange rate arrangement and policy dependence. We examine the empirical relevance of the argument by analysing the interactions between the Chinese and the US interest rates. Our empirical results, which appear robust to various assumptions of data persistence, suggest that the US effect on the Chinese interest rate is quite weak. Apparently, even with its de facto peg to the US dollar, China has alternative measures to retain its policy independence and de‐link its interest rates from the US rate. In other words, the argument for a flexible RMB to insulate China's monetary policy from the US effect is not substantiated by the observed interest rate interactions. Copyright © 2007 John Wiley & Sons, Ltd.
Bioactivity and osteoblast responses of novel biomedical nanocomposites of bioactive glass nanofiber filled poly(lactic acid)
Authors: Kim Hae‐Won , Lee Hae‐Hyoung , Chun Gae‐Sig 
Published: September 2007

AbstractBiomedical nanocomposites constituted of bioactive ceramic and resorbable polymer have shown promise for the successful regeneration of bone tissues. We developed herein a novel nanocomposite made up of a bioactive glass in a nanofibrous form and a degradable synthetic polymer, poly(lactic acid) (PLA). The glass nanofiber with a bioactive composition was generated via an electrospinning process with an average diameter of ∼320 nm. The nanofiber was homogenized with PLA solution at various concentrations (up to 35% nanofiber), followed by drying and thermal pressing to produce dense nanocomposites. The nanocomposites showed an internal morphology of uniformly dispersed nanofibers within the PLA matrix. The nanocomposites induced rapid formation of a hydroxycarbonate apatite layer on the surface under a simulated physiological medium. As the amount of bioactive nanofiber increased (from 5 to 25%), the in vitro bioactivity of the nanocomposite was improved. The osteoblast responses to the nanocomposites (compositions with 5 and 25% nanofiber) were assessed in terms of cell proliferation, differentiation, and mineralization. Osteoblasts attached and grew well on the nanocomposites and secreted collagen protein at initial culturing periods. The differentiation of cells, as assessed by the expression of alkaline phosphatase, was significantly improved on the nanocomposites as compared to those on pure PLA. Moreover, the mineralized product by the cells was observed to be significantly higher on the nanocomposites with respect to pure PLA. The newly developed nanocomposite constituted of bioactive nanofiber and degradable polymer is considered as a promising bone regeneration matrix with its excellent bioactivity and osteoblast responses. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Study of the effects of tissue reactions on the function of implanted glucose sensors
Authors: Dungel Paul , Long Nathan , Yu Bazhang , Moussy Yvonne , Moussy Francis 
Published: September 2007

AbstractThe relationship between tissue reactions to a subcutaneously implanted glucose sensor and the function of the sensor was evaluated over a period of 4‐weeks using tubular, porous polyvinyl alcohol (PVA) sponges implanted subcutaneously in rats. The PVA sponges were used as scaffolds in which the foreign body response could develop. Coil‐type glucose sensors were then placed in the center of the PVA sponges and tested on day 3, and weekly thereafter. In the first approach, the sensors were placed in the sponges still implanted in the rats and tested. In vivo glucose sensor sensitivity peaked at day 7 and steadily decreased until day 35. In the second approach, the sensors were placed in the explanted sponges and then tested. This test showed no sensor function after day 7, indicating that functional blood vessels are critical in maintaining any function whatsoever. In both cases the sensors themselves were never implanted to eliminate any potential in vivo degradation of the sensors that could have affected the outcome of this study. Sensors were then tested in absence of sponges and found to be working properly with no change from preimplantation sensitivity. Once sensor testing was concluded, the PVA sponge/tissue samples were prepared for quantitative histological analysis. It was determined that the increase in collagen deposition within the sponge correlated with the decrease in sensor sensitivity. It was also observed that natural angiogenesis (peak at day 14) did not overcome the barrier to glucose diffusion created by the fibrous capsule. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
The granulocyte colony stimulating factor (G‐CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line
Authors: Marino Verónica Julieta , Roguin Leonor Patricia 
Published: September 2007

AbstractGranulocyte colony‐stimulating factor receptor (G‐CSFR) has been found in placenta tissues, although its functional role has not yet been defined. In order to explore the molecular pathways induced by G‐CSF in this tissue, we first reveal the presence of G‐CSFR in the JEG‐3 human trophoblastic cell line and then examined the phosphorylation of Janus tyrosine kinases (Jak), signal transducers and activators of transcription (STAT) proteins and mitogen‐activated protein kinases (MAPK) after G‐CSF binding to receptors. We showed that Jak1, Jak2, Tyk2, and STAT3 were phosphorylated after incubation with G‐CSF. Phosphorylation of p38 and p44/42 MAPK was also activated by G‐CSF, and specifically blocked in the presence of the corresponding inhibitors. Similar intracellular pathways were induced by G‐CSF in a myeloid leukemia NFS‐60 cell line that was studied in parallel. Conversely to cytokine action in myeloid cells, G‐CSF did not induce a proliferative response in JEG‐3 cells. When the effect of G‐CSF on cellular viability was evaluated, cytokine‐stimulated JEG‐3 cells were protected from foetal serum starvation. In addition, when JEG‐3 cells deprived of serum were incubated at different times in the presence of G‐CSF, a progressive decrease in the percentage of hypodiploid cells was observed. In summary, we identified the molecular pathways activated after G‐CSF binding to trophoblastic cell receptors and showed that G‐CSF behaved as a protective cytokine, which supports JEG‐3 cells survival. J. Cell. Biochem. 103: 1512–1523, 2008. © 2007 Wiley‐Liss, Inc.
Signaling of DNA damage is not sufficient to induce p53 response: (Re)Activation of wt p53 protein strongly depends on cellular context
Authors: Węsierska‐Gądek Józefa , Gueorguieva Marieta , Komina Oxana , Schmid Gerald , Kramer Matthias P. 
Published: September 2007

AbstractIt is generally accepted that exposure of cells to a variety of DNA‐damaging agents leads to up‐regulation and activation of wild‐type (wt) p53 protein. We investigated the (re)‐activation of p53 protein in two human cancer cell lines in which the gene for this tumor suppressor is not mutated: HeLaS3 cervix carcinoma and MCF‐7 breast cancer cells, by induction via different genotoxic and cytotoxic stimuli. Treatment of human cells with the alkylating agent N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) or different anti‐cancer drugs resulted in a strong DNA damage as evidenced by Comet assay and a marked increase in site‐specific phosphorylation of H2AX. Unlike in MCF‐7 cells, in HeLaS3 cells the expression of p53 protein did not increase after MNNG treatment despite a strong DNA damage. However, other agents for example doxorubicin markedly induced p53 response in HeLaS3 cells. After exposure of these cells to MNNG, the ATM‐dependent effector proteins Chk2 and NBS1 were phosphorylated, thereby evidencing that MNNG‐induced DNA breakage was recognized and properly signaled. In HeLaS3 cells wt p53 protein is not functional due to E6‐mediated targeting for accelerated ubiquitylation and degradation. Therefore, the activation of a p53 response to genotoxic stress in HeLaS3 cells seems to depend on the status of E6 oncoprotein. Indeed, the induction of p53 protein in HeLaS3 cells in response to distinct agents inversely correlates with the cellular level of E6 oncoprotein. This implicates that the capability of different agents to activate p53 in HeLaS3 cells primarily depends on their inhibitory effect on expression of E6 oncoprotein. J. Cell. Biochem. 103: 1607–1620, 2008. © 2007 Wiley‐Liss, Inc.
Conformational memories with variable bond angles
Authors: Whitnell Robert M. , Hurst Dow P. , Reggio Patricia H. , Guarnieri Frank 
Published: September 2007

AbstractConformational Memories (CM) is a simulated annealing/Monte Carlo method that explores peptide and protein dihedral conformational space completely and efficiently, independent of the original conformation. Here we extend the CM method to include the variation of a randomly chosen bond angle, in addition to the standard variation of two or three randomly chosen dihedral angles, in each Monte Carlo trial of the CM exploratory and biased phases. We test the hypothesis that the inclusion of variable bond angles in CM leads to an improved sampling of conformational space. We compare the results with variable bond angles to CM with no bond angle variation for the following systems: (1) the pentapeptide Met‐enkephalin, which is a standard test case for conformational search methods; (2) the proline ring pucker in a 17mer model peptide, (Ala)8Pro(Ala)8; and (3) the conformations of the Ser 7.39 χ1 in transmembrane helix 7 (TMH7) of the cannabinoid CB1 receptor, a 25‐residue system. In each case, analysis of the CM results shows that the inclusion of variable bond angles results in sampling of regions of conformational space that are inaccessible to CM calculations with only variable dihedral angles, and/or a shift in conformational populations from those calculated when variable bond angles are not included. The incorporation of variable bond angles leads to an improved sampling of conformational space without loss of efficiency. Our examples show that this improved sampling leads to better exploration of biologically relevant conformations that have been experimentally validated. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2008
Effect of microbial transglutaminase on the protein fractions of rice, pea and their blends
Authors: Marco Cristina , Pérez Gabriela , Ribotta Pablo , Rosell Cristina M 
Published: September 2007

AbstractBACKGROUND: Transglutaminase (TG) is a transferase that has been used for crosslinking proteins. In general, those interactions are promoted within proteins of the same nature, and very few studies have been conducted for creating new bonds between proteins from different sources catalysed by TG. The effect of TG on the protein fractions of rice flour, pea protein isolate and their blends was studied by using different electrophoretic analyses (simple sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS‐PAGE) and multistaking SDS‐PAGE under reducing and non‐reducing conditions).RESULTS: TG induced the disappearance of numerous protein bands as a consequence of the formation of large protein polymers, linked by isopeptidic and disulfide bonds, with reduced solubility. The main protein fractions involved in those interactions were the albumins and globulins, from the pea protein isolate, and the rice flour; and the glutelins were also crosslinked.CONCLUSION: Composite flours containing the rice flour and the pea protein isolate are proposed for obtaining a protein‐enriched dough with better amino acid balance. Also a protein network formed of protein aggregates of high molecular weight can be created in the presence of transglutaminase. Copyright © 2007 Society of Chemical Industry
Physicochemical properties, total phenol and tocopherol of some Acacia seed oils
Authors: Falade Olumuyiwa S , Adekunle Abolanle S , Aderogba Mutalib A , Atanda Segun O , Harwood Chris , Adewusi Steve R 
Published: September 2007

AbstractBACKGROUND: Recently, there has been an increase in the number of investigations into the possible use of vegetable oils as a source of oleochemicals to supplement petrochemicals. We have therefore determined the physicochemical properties of Acacia oils and compared them with groundnut oil as a first step toward their possible industrial utilization.RESULTS: The chemical properties of Acacia oils compared well and surpassed those of groundnut oil in iodine value (1549.3, 1783.3 and 1093.1 g iodine kg−1 oil for A. colei, A. tumida and groundnut oils, respectively), saponification value (201.74, 202.15 and 198.01 g KOH kg−1 oil for A. colei, A. tumida and groundnut oils, respectively). Total phenol and tocopherol content of Acacia oils were also higher compared with groundnut oil. Refractive index, specific gravity and viscosity were higher in Acacia seed oils than in groundnut oil but the smoke point of Acacia oil was lower than that of groundnut oil. Acacia oils were higher in some essential elements (Mg, Ca, Fe, Zn and Cu) when compare with groundnut oil.CONCLUSION: The properties of Acacia oils revealed that they could be useful as drying oils, in soap making and as lubricants at low temperatures. They could also be dietary sources of natural antioxidants and essential elements. Copyright © 2007 Society of Chemical Industry