bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft tissue sarcomas in infancy and childhood
Authors: Wood Donald K. , Das Gupta Tapas K. 
Published: February 2007

AbstractThirty‐one soft tissue sarcomas in children were studied. The majority of these tumors occurred between the ages of 6 and 10; there were 18 boys and 13 girls. Three main histologic types were encountered, 14 children had fibrosarcoma, 13 rhabdomyosarcoma, 2 had solitary malignant schwannoma, and in 2 the histogenetic origin could not be determined. Head and neck region was found to be the most common anatomical site, and 16 of 31 patients had their primary tumors in this region. In the rhabdomyosarcoma group of the 11 eligible patients, 6 lived free of disease for 5 years; in the fibrosarcoma group of the 12 eligible patients, 6 lived for 5 years or more. Both children with solitary malignant schwannoma are living. It is proposed that rhabdomyosarcoma in children be treated by combining irradiation, chemotherapy, and surgery while fibrosarcoma should be treated by excision alone. Furthermore, it is also proposed that, when the histogenetic type of a tumor can not be determined, these children be treated as having rhabdomyosarcoma.
Cancer chemotherapy by intra‐arterial infusion with adriamycin
Authors: Di Pietro S. , De Palo G. M. , Gennari L. , Molinari R. , Damascelli B. 
Published: February 2007

AbstractAdriamycin was given by arterial infusion to 32 patients with different types of advanced cancer. The drug was used for inducing the first remission. In responsive cases maintenance treatment was given with conventional agents. Twenty‐six patients were adequately evaluable. Seventeen patients adequately treated showed objective improvement and 7/17 regression >50%. Head and neck cancer was the disease most sensitive to adriamycin by arterial infusion. Of 32 patients receiving adriamycin, 23 had one or more side effects, 14 had morbidity, and 2 patients died. In comparison with other conventional drugs, adriamycin by prolonged arterial infusion produces a higher percentage of side effects and not a higher percentage of therapeutic response.
Horrifying basal cell carcinoma: A study of 33 cases and a comparison with 435 non‐horror cases and a report on four metastatic cases
Authors: Jackson Robert , Adams Rowan H. 
Published: February 2007

AbstractThirty‐three horror basal cell carcinomas (18 large, six destructive, five locally uncontrollable, and four metastatic) were studied in detail. In comparison with a series of non‐horror cases, it was found that there were more horror cases in men and that the age of onset of horror tumors was earlier. The anatomical site was the same. Basic etiological factors included habitual sun exposure in 13, mustard gas burns in two, and one each of radioermatitis, trivalent arsenic ingestion and naevoid basal cell carcinoma syndrome. Fifteen had no obvious cause. It could not be shown that initial treatment with radiotherapy caused any change in the biological nature of the cancer. In 17 cases no medical treatment was sought until after the cancer had been present for over five years. It is concluded that these rare cancers, histologically indistinguishable from the ordinary basal cell carcinoma, are, from their onset, either biologically more aggressive or occur in patients with a lower tumor host resistance. Unfortunately apart from their bizarre biological behavior, we do not have any means of distinguishing them at their onset from the usual basal cell carcinoma.
Major surgery in hodgkin's disease and other malignant lymphomas
Authors: Lee Yeu‐Tsu N. , Say Carlos , Hori Jose M. , Spratt John S. 
Published: February 2007

AbstractThis is a retrospective and all‐inclusive study of 527 patients with malignant lymphoma. A total of 178 major surgical procedures were carried out on 139 patients (an incidence rate of 18.4% for the 163 patients with Hodgkin's disease and 29.9% for the 364 with other lymphomas). There were 101 procedures done initially for diagnosis and 77 carried out after the diagnosis was established. Only 15 patients had laparotomies for staging purposes. The other operations included 59 celiotomies for diagnosis (21 had resection of organs), 42 abdominal operations for complications (malignant or nonmalignant), 11 radical node dissections, 6 radical mastectomies, 5 laminectomies, 4 thoracotomies, 3 bone operations, and 33 various other procedures.With the wider application of the exploratory laparotomy for staging and the improved survival with radiotherapy and chemotherapy, it is obvious that the future role of surgery will be quite different from the past. However, certain patients will still require major surgery for diagnosis. In addition, second cancers, conditions unrelated to lymphoma, complications secondary to aggressive therapy all may need surgical management.
Prostatic cancer with bone marrow involvement and long‐term survival: Association with intravenous chemotherapy
Authors: Boatman D. L. , Nelson C. M. K. , Flocks R. H. , Schmidt J. D. 
Published: February 2007

AbstractProstatic cancer with metastatic disease generally is associated with a short survival. A 68‐year‐old man has survived 10 years following total prostatectomy for a clinical Stage B lesion. Repeatedly positive bone marrow aspirates reverted to normal following a short course of intravenous nitrogen mustard and diethylstilbestrol disphosphate chemotherapy. To date there is no objective evidence of tumor recurrence, either locally or distant. Chemotherapy to eradicate micrometastatic disease may be an important adjunct to removal of the local lesion of prostatic carcinoma in selected patients.
The effect of treatment with L–phenylalanine mustard and L–phenylalanine mustard antibody on the survival time of mice with intracerebral ependymoblastomas
Authors: Papadakis N. , Burke J. F. , Mark V. H. 
Published: February 2007

AbstractPrevious work has shown a decreased rate of growth of mouse ependymoblastomas treated with an antigen which fixes to the cell wall, followed by an antibody to the tumor cell marker. The present study was designed to compare the survival time of mice with intracerebrally implanted ependymoblastomas that were treated with the above method with the survival time of controls. Eight groups of C3 H male mice were subjected to intracerebral implantation of ependymoblastoma. Five days following implantation, each group was subdivided into four subgroups, and the subgroups were treated with intravenous normal saline, intravenous antibody, intracarotid L–phenylalanine mustard and intracarotid L–phenylalanine mustard followed by intravenous antibody, respectively. The treated mice showed statistically significant increase of survival time, as compared with the controls. It is possible that by changing some of the treatment parameters, more long‐term results can be achieved.
The gallium‐67 scan in clinical assessment of cancer
Authors: Johnston G. S. , Jones A. E. , Frankel R. L. , Kramer R. J. , Arseneau J. C. 
Published: February 2007

AbstractBy 1 April 1973, 770 patients with malignancy were studied using Gallium‐67 (67Ga) citrate radioisotopic scanning at the Clinical Center, National Institutes of Health. Of these, 21 had brain tumors, 19 (90%) of which concentrated 67Ga. Forty‐four patients with melanoma had 54% of proven sites visualized on 67Ga scan (masses larger than 2 cm were detected in 75% of the sites). Ewing's sarcoma was studied in 15 patients with 67Ga scanning and all 15 primary tumors were visualized. Thirty‐two of 43 scans performed on 30 patients with acute leukemia were abnormal. Sites of leukemic involvement in bone marrow and as myeloblastomas in soft tissue contained high levels of 67Ga. Patients with untreated Hodgkin's disease were abnormal in 90% of cases on 67Ga scan with 70% of proven sites of involvement being detectable. Sixty percent of non‐Hodgkin's lymphoma sites were detected on 67Ga scans. Approximately 85% of anatomic sites involved with lung cancer were detected on scan. 67Ga citrate whole body scanning has proven to be useful in diagnosing and staging a wide variety of human tumors. The 67Ga study is most reliable when positive findings are recorded, but should be approached with caution when the findings are negative.
Use of gallium‐67 scanning in the management of lymphoma
Authors: Bakshi S. , Bender M. A. 
Published: February 2007

AbstractThere has been considerable interest recently in the possibility that gallium‐67 citrate may be of clinical value as a tumor seeking scanning agent. Since its discovery by Edwards and Hayes (1969), a number of reports have been published recording uptake in a variety of tumors, both primary and metastatic (Higasi et al., 1970; Winchell et al., 1970). The observation of Hayes et al. (1970), based on autoradiographs of experimental tumors, that the radioisotope is taken up in the cytoplasm in malignant cells and that uptake is greater in viable than in necrotic tumor has stimulated its use in following patients with lymphoma to assess the efficacy of the therapy administeted.At our Institution an assessment has been made of the potential value of 67Ga citrate scanning in the management of lymphoma. Interesting scans showing the usefulness and difficulties with this agent are presented. A total of 79 scans were reviewed. The majority of the patients studied has received either chemotherapy or radiotherapy prior to scanning. Uptake was detected in 42 cases with active disease (53%); no uptake was noted in 28 cases (36%) without active disease, and in 9 cases (11%) the scan gave a false‐positive or a false‐negative result.The conclusions of this study are (1) 67Ga scanning is useful in establishing the extent of lesions as well as the presence of undetected disease, (2) 67Ga scanning is especially useful for the evaluation of the effectiveness of therapy.
Technique of exploratory laparotomy and staging in hodgkin's disease
Authors: Mittelman Arnold , Elias Elias G. 
Published: February 2007

AbstractExploratory laparotomy, splenectomy, liver biopsy, multiple lymph node biopsy, and bone biopsy have been successfully carried out in 76 patients with Hodgkin's disease. The superiority of these procedures for accurate determination of extent of abdominal disease is clear. A surgical technique of staging is described that has, to date, no mortality and insignificant morbidity.
In vitro lymphocyte blastogenesis: A prognostic test in patients with neoplastic disease
Authors: Han Tin 
Published: February 2007

AbstractThe in vitro lymphocyte response to PHA was studied in patients with Hodgkin's disease, bronchogenic calcinoma, and chronic lymphocytic leukemia; the results were correlated with the clinical and immunologic status of these patients. The lymphocyte blastogenesis was normal among patients in remission, except in a few instances in which depression could be attributed to antecedent therapy: PHA response varied greatly among patients with active Hodgkin's disease and appeared to be affected by a variety of factors related to the disease and to treatment. The mean PHA response in patients with bronchogenic carcinoma was significantly depressed as compared to that of normal subjects. There was a correlation between lymphocyte blastogenesis and the extent of the disease or survival of these patients with bronchogenic carcinoma. The PHA response was markedly depressed and delayed in almost all patients with active chronic lymphocytic leukemia, and it was only slightly or moderately depressed, but somewhat delayed, in some patients in remission. The lymphocyte response correlated well with the duration of disease, the status of therapy, the status of disease, the degree of lymphocytosis, and the immunologic status of these patients in chronic lymphocytic leukemia.
Hemoglobin II immunogenic properties of stroma vs. stroma‐free hemoglobin solution
Authors: Cochin Alan , Gupta Tapas K. Das , Dewoskin Richard , Moss Gerald S. 
Published: February 2007

AbstractIn recent years there has been considerable interest in the use of hemoglobin solution as a volume expander. This solution would be able to both pick‐up and off‐load oxygen as well as expand the circulating value. It is extremely important to know whether or not hemoglobin itself as well as stroma is antigenic, since an affirmative answer would preclude its use as a plasma expander.To obtain this answer, the following study was carried out. A group of white rabbits were challenged over a 21‐day period with either saline solution, hemolysates containing various concentrations of stroma, or stroma‐free hemoglobin solution. We found that stroma produced marked increase in gamma to globulin concentrations, phospholipid concentrations, and clotting times. In addition, marked thrombocytopenia was also noted. In contrast we found no such changes in animals given either saline solution or stroma‐free hemoglobin solution. The data indicate that the stroma is antigenic but that hemoglobin solution without stroma is not.
Extracorporeal chemotherapy with L‐asparaginase in man
Authors: Sampson Derek , Han Tin , Hersh Lee S. , Murphy Gerald P. 
Published: February 2007

AbstractAn extracorporeal chemotherapy unit has been used in baboons and man. Blood was perfused over plates coated with L‐asparaginase in 4 hour perfusion studies. It was possible to lower serum asparagine levels almost to zero, and to render both human and animal lymphocytes unreactive to mitogenic stimulation. The toxicity associated with L‐asparaginase was avoided and the potential application of this technique to the treatment of human lymphatic leukemia is discussed.
Scalene node excision biopsy in advanced prostate carcinoma
Authors: Sy Fabian A. , Gursel Erol O. , Veenema Ralph J. , Buda Joseph 
Published: February 2007

AbstractIn 12 patients with disseminated prostate carcinoma, supraclavicular lymph node biopsy was performed. In 3 patients with palpable supraclavicular node, tumor cells were found in the lymph nodes. In the remaining 9 in whom there were no palpable nodes, unilateral left scalene lymph node excision biopsy revealed no evidence of tumor cells in the nodes in spite of diffuse bone metastasis. These findings suggest that unilateral scalene node biopsy did not provide additional information and has no advantage over the known parameters in staging of prostatic cancer.
Treatment of metastatic carcinoma of the prostate to bone with parathormone and radioactive phosphorous
Authors: Merrin Claude , Bakshi Suraj 
Published: February 2007

AbstractEight patients with metastases to bone from carcinoma of the prostate were treated with a combination of parathyroid hormone and radioactive phosphorous. Seven of 8 patients reported substantial pain relief ranging from 1 to 8 months in duration. Several chemical parameters were altered during the priming period with parathyroid hormone but no objective response to the combination therapy was observed.
Anticancer therapy with Hydrea: Comparative study of daily vs, intermittent oral dosage
Authors: Ariel Irving M. 
Published: February 2007

AbstractNo significant difference can be demonstrated in this evaluation between daily doses and intermittent doses of Hydrea in either subjective or objective response. Although a slightly better result was obtained by the daily dose in patients with malignant melanoma, colonrectum carcinoma, sarcoma, and ovarian cancer. No significant increase in longevity was noted by the intermittent dose over the daily dose. Because the difference between the two methods of administration is so slight, the intermittent method recommends itself because of the superior hematopoietic picture that can be maintained following its implementation.
Timing of pedicle flap delays by measurements of flap oxygen and carbon dioxide
Authors: Reisin Jorge H. , Guthrie Randolph H. , Goulian Dicran 
Published: February 2007

AbstractOxygen and carbon dioxide partial pressures in canine pedicle flaps are measured with a mass spectrometer before and for a week following flap manufacture. These partial pressures are a direct reflection of a flap's blood supply. The initial insult to cutaneous blood circulation and its subsequent recovery are clearly documented.
Prognostic criteria of renal cell carcinoma
Authors: Varkarakis M. J. , Bhanalaph T. , Moore R. H. , Murphy G. P. 
Published: February 2007

AbstractThe survival data of 186 patients with renal cell carcinoma are discussed in respect to the different forms of treatment and other prognostic criteria, such as clinicopathological staging of the disease, histological grading, and cell type of the tumor. Patients with localized renal tumors (stage I) have a better prognosis than those with lesions extending into the perinephric fat, perinephric lymph nodes, or renal vein. Simple nephrectomy in isolated renal tumors (stage I) has provided a 55.1% 5 year survival and a 35.1% 10 year survival. In the more extensive stage (II and III), the therapeutic effect of nephrectomy is less apparent. The prognosis in stages II and III is almost similar. In the disseminated form of the disease, the prognosis has been poor and of all the past forms of treatment which have been previously employed, nephrectomy offered the best survival rate.For different forms of the disease, nephrectomy in combination with radiotherapy, chemotherapy, or immunotherapy, may enhance the rejection effect of the host toward the tumor. However, this combination of therapy remains to be further clinically evaluated.
Preferential splenic metastases in parabiotic animals
Authors: Schour Lionel , Faraci Robert P. 
Published: February 2007

AbstractA reticulum cell sarconia which metastasizes preferentially to the spleens of inbred C3 H mice has been studied. Placement of tumor‐bearing animals in parabiosis with normal animals was followed by the development of gross metastases limited to the spleen in 100% of the normal animals. The pattern of metastases observed when a tumor‐bearing animal was placed in parabiosis with a splenectomized animal is described. The splenotrophic tendencies of this tumor and its ability to metastasize selectively across a parabiotic union provide a model for investigation of the role of immunity and humoral factors in tumor metastases.
The influence of osteolytic substances on the production of osseous metastases from walker 256 sarcoma in rats
Authors: Graham William P. , Tragus Eugene T. , Blakemore William S. 
Published: February 2007

AbstractReports in the early 1960's suggested the possible relationship between the humoral agents producing hypercalcemia in metastatic malignancy and the appearance of osseous metastases. Hartmann and Sherlock indicated that the use of corticosteroids possibly might alter the ease with which metastases to the gastrointestinal mucosa occur in breast carcinoma. The present study was an attempt to verify the previous observations of Pentimalli (1960) that hypercalcemia could produce bony metastases in rats.Using saline controls, ergosterol, methylprcdnisolone, and parathyroid hormone, no bony metastases could be demonstrated in rats implanted with Walker 256 sarcoma. It appears that these osteolytic substances at least within this model do not facilitate the appearance of metastases to bone.
Chromosomes and cancer
Authors: Bishun N. P. , Raven R. W. , Williams D. C. 
Published: February 2007

AbstractIt has now become abundantly clear that in recent years a multiplicity of chemical, physical, and other agents to which man is exposed are capable of damaging his chromosomes. The effects of these agents on the human somatic and possibly germ cells have now been well documented, although not without some controversy over the interpretation and implications of the data. While biological and clinical significance of chromosomal aberrations are not as yet well understood, recent epidemiological evidence, from mutagen‐exposed human populations, and recent experiments on viral‐induced transformation of chromosomally abnormal cells, suggest an association between chromosome aberrations and oncogenesis.
Pancreatic islet cell carcinoid: A highly malignant form of carcinoid tumor
Authors: Greene John F. , Doyle William F. 
Published: February 2007

AbstractA 23‐year‐old man died four months after being admitted to the hospital because of back pain, 9.9 kg weight loss in 2 months, 8 to 10 loose stools per day, and periodic sweating. The carcinoid syndrome was present but no hypoglycemia. At autopsy, malignant carcinoid tumor was found in the pancreas. No other tumor was found in the usual primary sites for carcinoids. Biochemical findings and clinical data in retrospect support the morphologic diagnosis of pancreatic islet cell carcinoid tumor. Our case and a review of the literature emphasize that metastasizing tumors of the pancreas associated with excessive production of indolic compounds are frequently aggressive and the survival time is short (range 3 months to 4 years; mean 15 months).
The transitory nature of a transmissible entity controlling the growth of a spontaneous tumor in mice
Authors: Strong L. C. , Matsunaga H. 
Published: February 2007

AbstractTwo hundred and sixty‐three control mice of the C3 H/ST inbreds bearing spontaneous tumors of mammary gland origin have been studied in reference to the injection of a specially prepared liver extract into one or more of their ancestors. Of these, 24 mice were from the original inbred strain in which no liver extract had ever been injected. Two hundred and thirty‐nine mice were among the descendants of a mouse that had received an intraperitoneal injection of a liver emulsion. These 239 mice were spread over 15 generations of lineal descent. All mice (263) of this experiment were kept as “controls” when their spontaneous tumors arose. The evidence obtained with the analysis of the growth rate of these tumors indicated the activity of a “transmissible entity” which increased in potency in suppressing these cancerous growths. The new evidence, obtained after six generations of lineal descent separation from the original injection of the liver extract, demonstrated quite convincingly that the amount of tumor inhibition became erratic and finally disappeared. The value of growth rate of tumors in mice of the 15th generation returned to the original rate obtained in mice of the 0 class in which there had been no treatment with liver extract in their ancestry.
Culturing breast tumor cells in the presence of hormones
Authors: Bishun N. P. , Mills J. , Raven R. W. , Williams D. C. 
Published: February 2007

AbstractA tissue culture technique for culturing human breast tumor cells was utilized to invesitgate the response of these cells to various hormones. Due to the small number of tumors investigated, no definite pattern of response was evident. However, the methods described may provide information which can be of useful clinical importance.
Lung scan in the diagnosis of bronchogenic carcinoma
Authors: Didolkar Mukund S. , Takita Hiroshi 
Published: February 2007

AbstractWhen chest roentgenograms fail to reveal the presence of a lesion in a patient suspected t o have bronchogenic carcinoma, perfusion lung scanning with radioiodinated macroaggregated human albumin (1‐131 M.A.A.) is of great help in the diagnosis and localization of the bronchogenic carcinoma. Marked decrease in perfusion of the affected lung area is detected on lung scan in early hilar and parahilar lesions which are not even seen on chest roentgenograms. Two such cases are presented. Lung scan is safe and easy to perform.
About oncological operations
Authors: Gritsman J. J. 
Published: February 2007

AbstractThe following article describes some peculiarities of oncological operations stemming from the experience and methodology of the Hertzen Moscow Scientific Research Oncological Institute. It defines the place of surgical method in contemporary combined treatment of oncological patients. It mentions main components of dependable oncological diagnosis, which serves as a fundamental factor for establishing ways of treatment and, in particular, its surgical component. At the same time the article deals with a notion of oncological zone or region and the questions of evaluation of radicalism of operation.