bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chick Lit
Authors: Montoro Rocío , Zaganor Sena Hilal 
Published: February 2024

Abstract
In this paper, we look at characterisation in the popular fiction genre Chick Lit by analysing laughter-talk in
conversational humour. This is the first systematic analysis of how a variety of humour phenomena are linguistically realised in
the genre despite humour being as aspect recurrently referred to as intrinsic to the genre. We use a combination of methods, both
corpus-based and qualitative in nature, to identify instances in which laughter occurs, which we (broadly) associate with the
presence of humour. Thus, with the use of self-compiled corpora, we assess the nature of humorous mechanisms in the genre. We
conclude by arguing that humorous encounters are genre-defining and essential for characterisation. Humour analysis allows us to
argue that Chick Lit protagonists are prototypically presented as non-aggressive, non-threatening individuals, which also
contributes to the depiction of down-to-earth characters readers expect in the genre.
Chinese “face”-related expressions in Peking and Teochew Opera scripts
Authors: Chen Jiejun , House Juliane , Kádár Dániel Z. 
Published: February 2024

Abstract
This paper presents a historical contrastive pragmatic study of the use of Chinese “face”-related expressions in
Peking and Teochew Opera scripts. The rationale behind this investigation is that contemporary Mandarin and the Minnan Dialect
operate with very different inventories of “face”-related expressions, and it is worth considering whether this difference also
applies to historical language use, and, if so, how. Studying this matter is particularly relevant for historical pragmatic
research because “face”-related expressions have been under-represented in the field. Our study is based on a corpus of nineteen
Peking Opera scripts and a comparable corpus of nineteen Teochew Opera scripts, dating from the sixteenth and seventeenth
centuries. The results of our analysis show that the historical Mandarin corpus operates with a duality of the “face”-related
expressions lian and mian, in a similar way to modern Mandarin, even though we also found
differences between the ways in which these expressions were used in former times and at present. Yet such differences are
eclipsed if we contrast historical Mandarin with the Teochew scripts where we found a very different “face” duality than in
Mandarin, namely a duality of yan and mian. This duality also differs from what one can witness
in present-day Minnan.
Corrigendum to “A Severi type theorem for surfaces in ℙ⁶”
Authors: De Poi Pietro , Ilardi Giovanna 
Published: February 2024

In Theorem 0.1 of the paper “A Severi type theorem for surfaces in

P

6

\mathbb {P}^6

” [Proc. Amer. Math. Soc. 149 (2021), pp. 591–605], we claimed to have given a complete classification of smooth surfaces in

P

6

\mathbb {P}^6

with one 4-secant plane through the general point of

P

6

\mathbb {P}^6

, but the classification is still incomplete.
Greek inspiration
Authors: Rozelle-Stone A. Rebecca 
Published: February 2024

Abstract
Weil’s education in philosophy was, from early on, classical; therefore, the story of her thought begins with an examination of the influence of ancient Greek philosophy and literature on her thinking. Having learned Greek at a young age, Weil was inspired by ideas she found in the writings of Homer, Sophocles, Aeschylus, Plato, and others. Weil was no mere exegete of their writings. Indeed, she often made unorthodox interpretations that fitted with her eclectic influences and unique Christian outlook, such as her claim that Plato is a mystic. This chapter is centred on four important social, political, and ethical themes that emerged from her deep familiarity with and admiration for the ancient Greek tradition, namely: the nature of power and balance (or equilibrium); justice (in contradistinction to ‘rights’); the relation between contradiction and truth; and desire for the good. The omission of Aristotle from the group of Greek thinkers that were explicitly formative in Weil’s philosophical development is also addressed at the outset of the chapter. In many ways, this chapter serves as a brief introduction to Weil’s metaphysics, which will be further elaborated in the remainder of the book.
Labour and politics
Authors: Rozelle-Stone A. Rebecca 
Published: February 2024

Abstract
This chapter explores Weil’s political philosophy, beginning with the experiences and corresponding ideas from her time in the factories, which she recorded in her Factory Journal, including the effects of monotonous factory work on the soul: fatigue, alienation, affliction, and humiliation. Weil understood the importance of governing bodies, social practices, customs, and opportunities for work and relationality that are scaled to reflect human needs in an ideal society, but what she observed in early 20th-century France was a society geared more towards machines, profit, automation, and efficiency than persons. While her reflections upon the problems of monotonous work and the conditions for dignified labour constitute the first part of this chapter, subsequent sections include her critiques of Marxist theory regarding the liberation of the workers and the notion of revolution itself, as well as the problems with political rhetoric and political parties. The end of the chapter examines Weil’s descriptions of the needs of the human soul and her vision for an ideal society, along with some possible limitations of these ideas.
Earthquakes and tsunamis
Authors: McGuire Bill 
Published: February 2024

Abstract
Earthquakes are our planet’s way of releasing strain accumulated as a consequence of the relative movements of the tectonic plates. In doing so, they take an enormous toll on lives and livelihoods, to the extent that they are responsible—on average—for around 20,000 deaths a year. Earthquakes can happen anywhere on the planet, but the deadliest occur around the Pacific Rim and in a band stretching from southern Europe eastwards through central Asia and into China. Major submarine earthquakes on so-called mega-thrusts can trigger tsunamis that can take many tens of thousands of lives. Most people who die in earthquakes, however, do so due to building collapse, which is almost entirely the result of poor construction, leading to buildings that are unable to withstand the strong ground shaking caused by powerful seismic waves. The size of an earthquake is denoted by its Moment Magnitude, while the intensity of shaking is determined using the Modified Mercalli Scale. The locations of future earthquakes may be narrowed down by looking for seismic gaps, where a quake has not happened for longer than expected. Although there are sometimes precursory warning signs it is not, however, possible to accurately predict an earthquake, and it may never be possible. Consequently, the only way to reduce their impact is to build better, ensuring that structures are life-safe so that they stay upright when the ground shakes.
Effect of low- versus high-dose 4-factor prothrombin complex concentrate in factor Xa inhibitor–associated bleeding: A qualitative systematic review
Authors: Phillips Anna , Bradley Colby , Cash Julie , Sangiovanni Ryan , Wingerson Charles 
Published: February 2024

Abstract

Purpose
The purpose of this review is to evaluate current literature on the treatment of factor Xa inhibitor–associated bleeds with 4-factor prothrombin complex concentrate (4F-PCC), with a focus on the effect of low versus high dosing of 4F-PCC on hemostatic efficacy and safety outcomes.

Summary
A search of PubMed and EBSCOhost was performed to identify studies evaluating patients with a factor Xa inhibitor–bleed treated with 4F-PCC at either low or high doses. Studies of patients receiving alternative reversal agents such as fresh frozen plasma and andexanet alfa or where no comparator group was evaluated were excluded from the analysis. To assess the effect of these 4F-PCC dosing strategies, the primary outcome of interest was hemostatic efficacy. Four studies meeting inclusion criteria were included in this review. In each of the included studies, similar rates of hemostatic efficacy, hospital mortality, and venous thromboembolism were observed in the low- and high-dose cohorts.

Conclusion
These results suggest low- and high-dose 4F-PCC may confer similar clinical effectiveness and safety; however, these findings should be evaluated and confirmed with future prospective studies.
Large animal models of pressure overload-induced cardiac left ventricular hypertrophy to study remodelling of the human heart with aortic stenosis
Authors: Beslika Evangelia , Leite-Moreira Adelino , De Windt Leon J , da Costa Martins Paula A 
Published: February 2024

Abstract
Pathologic cardiac hypertrophy is a common consequence of many cardiovascular diseases, including aortic stenosis (AS). AS is known to increase the pressure load of the left ventricle, causing a compensative response of the cardiac muscle, which progressively will lead to dilation and heart failure. At a cellular level, this corresponds to a considerable increase in the size of cardiomyocytes, known as cardiomyocyte hypertrophy, while their proliferation capacity is attenuated upon the first developmental stages. Cardiomyocytes, in order to cope with the increased workload (overload), suffer alterations in their morphology, nuclear content, energy metabolism, intracellular homeostatic mechanisms, contractile activity, and cell death mechanisms. Moreover, modifications in the cardiomyocyte niche, involving inflammation, immune infiltration, fibrosis, and angiogenesis, contribute to the subsequent events of a pathologic hypertrophic response. Considering the emerging need for a better understanding of the condition and treatment improvement, as the only available treatment option of AS consists of surgical interventions at a late stage of the disease, when the cardiac muscle state is irreversible, large animal models have been developed to mimic the human condition, to the greatest extend. Smaller animal models lack physiological, cellular and molecular mechanisms that sufficiently resemblance humans and in vitro techniques yet fail to provide adequate complexity. Animals, such as the ferret (Mustello purtorius furo), lapine (rabbit, Oryctolagus cunigulus), feline (cat, Felis catus), canine (dog, Canis lupus familiaris), ovine (sheep, Ovis aries), and porcine (pig, Sus scrofa), have contributed to research by elucidating implicated cellular and molecular mechanisms of the condition. Essential discoveries of each model are reported and discussed briefly in this review. Results of large animal experimentation could further be interpreted aiming at prevention of the disease progress or, alternatively, at regression of the implicated pathologic mechanisms to a physiologic state. This review summarizes the important aspects of the pathophysiology of LV hypertrophy and the applied surgical large animal models that currently better mimic the condition.
‘Tanto di Capuccini come di Giesuiti’: Religious Orders, Exceptionalism and the Absolution of Heretics in Early Modern Italy
Authors: Wärnberg Jessica M 
Published: February 2024

Abstract
From the first history of the Society of Jesus, written in the late sixteenth century, to modern scholarship on the order, texts by and about Jesuits have suggested that their approach to sacramental confession distinguished them from other religious groups in the eyes of the laity and ecclesiastical hierarchy. Recent histories have suggested that the particular spirituality, approach and talent of the Society’s confessors compelled popes to single out the Jesuits for privileges, empowering the Society as a papal task force in the fight against heresy. Focusing on the privilege of absolving heretics in confession, this article challenges this notion, arguing that popes empowered religious orders, including the Jesuits, for pragmatic reasons, not because of their particular charism or way of proceeding. The article compares the status and character of religious orders that emerged in the same period as the Jesuits to show that it was the Society’s scale, availability and orthodoxy that compelled popes to grant them the privilege of absolving heretics, allowing them to reconcile heretics autonomously where papal inquisitors could not. Using records from the Jesuit archive and the archive of the Roman Inquisition, the article confirms this conclusion with a case-study of privileges granted to Jesuit and Capuchin missionaries in Savoy–Piedmont at the turn of the seventeenth century. There, popes empowered both orders alike depending on practical need and availability, and despite the fact that the Capuchins had initially refused to administer the sacrament of confession.
35th Sharing Session – On SEPs – Standing Committee on the Law of Patents, WIPO, Geneva
Authors: Tochtermann Lea 
Published: February 2024

Abstract
WIPO’s Standing Committee on the Law of Patents (SCP) is in the early stages of placing standard essential patents (SEPs) on its agenda. Taken up at the initiative of the delegation of Canada, initial deliberations on the topic show cautious efforts to assess the current situation on very basic terms with the goal of achieving an understanding of the matter. On this basis, the SCP will evaluate whether WIPO should envisage taking action in the future and what form such action should take.
A new tort of inducing a breach of trust?
Authors: Pawlowski Mark , Brown James 
Published: February 2024

Abstract
This article considers whether a new tort of inducing a breach of trust would be a welcome development in English law. It is envisaged that any such new tort would inevitably have similar characteristics to the existing tort of inducing a breach of contract, namely, that the defendant: (1) acted with the requisite knowledge of the existence of a trust and (2) deliberately intended to interfere with the duties of the trustee. Actual knowledge would not be essential as it would be enough that the defendant turned a blind eye to the facts. The new tort would allow a claimant to pursue a third party where his/her wrongdoing consisted solely of threats or persuasion falling short of actual participation in, or the facilitation of, a breach of trust. Moreover, the tort would impose liability on the third party without proof of dishonesty provided that s/he had knowledge of the trust and the requisite intention to cause a breach. Apart from the remedy of damages, the claimant would have the advantage of seeking an injunction to restrain any threatened or future inducement. Aggravated damages could also be recovered in appropriate circumstances.
Prenatal prednisone exposure impacts liver development and function in fetal mice and its characteristics
Authors: Dai Yongguo , Peng Yu , Lu Zhengjie , Mao Tongyun , Chen Kaiqi , Lu Xiaoqian , Liu Kexin , Zhou Xinli , Hu Wen , Wang Hui 
Published: February 2024

Abstract
Prednisone, a widely used glucocorticoid drug in human and veterinary medicine, has been reported to cause developmental toxicity. However, systematic studies about the effect of prednisone on fetal liver development are still unclear. We investigated the potential effects of maternal exposure to clinically equivalent doses of prednisone during different gestational stages on cell proliferation and apoptosis, cell differentiation, glucose and lipid metabolism, and hematopoiesis in the liver of fetal mice, and explored the potential mechanisms. Results showed that prenatal prednisone exposure (PPE) could suppress cell proliferation, inhibit hepatocyte differentiation, and promote cholangiocyte differentiation in the fetal liver. Meanwhile, PPE could result in the enhancement of glyconeogenesis and bile acid synthesis and the inhibition of fatty acid β-oxidation and hematopoiesis in the fetal liver. Further analysis found that PPE-induced alterations in liver development had obvious stage and sex differences. Overall, the alteration in fetal liver development and function induced by PPE was most pronounced during the whole pregnancy (GD0–18), and the males were relatively more affected than the females. Additionally, fetal hepatic insulin-like growth factor 1 (IGF1) signaling pathway was inhibited by PPE. In conclusion, PPE could impact fetal liver development and multiple functions, and these alterations might be partially related to the inhibition of IGF1 signaling pathway.
Kielin/chordin‐like protein deficiency aggravates pressure overload‐induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice
Authors: Xu Yao , Zheng Zihui , Pan Heng , Zhao Mengmeng , Zhang Jishou , Peng Shanshan , Liu Jianfang , Pan Wei , Yin Zheng , Xu Shuwan , Wei Cheng , Qin Juan‐Juan , Lin Yingzhong , Wan Jun , Wang Menglong 
Published: February 2024

AbstractTargeting cardiac remodeling is regarded as a key therapeutic strategy for heart failure. Kielin/chordin‐like protein (KCP) is a secretory protein with 18 cysteine‐rich domains and associated with kidney and liver fibrosis. However, the relationship between KCP and cardiac remodeling remains unclear. Here, we aimed to investigate the role of KCP in cardiac remodeling induced by pressure overload and explore its potential mechanisms. Left ventricular (LV) KCP expression was measured with real‐time quantitative PCR, western blotting, and immunofluorescence staining in pressure overload‐induced cardiac remodeling in mice. Cardiac function and remodeling were evaluated in wide‐type (WT) mice and KCP knockout (KO) mice by echocardiography, which were further confirmed by histological analysis with hematoxylin and eosin and Masson staining. RNA sequence was performed with LV tissue from WT and KO mice to identify differentially expressed genes and related signaling pathways. Primary cardiac fibroblasts (CFs) were used to validate the regulatory role and potential mechanisms of KCP during fibrosis. KCP was down‐regulated in the progression of cardiac remodeling induced by pressure overload, and was mainly expressed in fibroblasts. KCP deficiency significantly aggravated pressure overload‐induced cardiac dysfunction and remodeling. RNA sequence revealed that the role of KCP deficiency in cardiac remodeling was associated with cell division, cell cycle, and P53 signaling pathway, while cyclin B1 (CCNB1) was the most significantly up‐regulated gene. Further investigation in vivo and in vitro suggested that KCP deficiency promoted the proliferation of CFs via P53/P21/CCNB1 pathway. Taken together, these results suggested that KCP deficiency aggravates cardiac dysfunction and remodeling induced by pressure overload via P53/P21/CCNB1 signaling in mice.
Efficacy and Safety of Valbenazine in Japanese Patients With Tardive Dyskinesia and Schizophrenia/Schizoaffective Disorder or Bipolar Disorder/Depressive Disorder
Authors: Nagano Mieko , Susuta Yutaka , Masui Hideaki , Watanabe Yumi , Watanabe Koichiro 
Published: February 2024

Abstract

Purpose
This post hoc analysis investigated whether a patient's underlying psychiatric disease (schizophrenia/schizoaffective disorder [SCHZ] or bipolar disorder/depressive disorder [MOOD]) influenced the efficacy or safety of valbenazine for tardive dyskinesia (TD) in an Asian population.

Methods
We analyzed data from J-KINECT, a multicenter, phase II/III, randomized, double-blind study, which consisted of a 6-week placebo-controlled period followed by a 42-week extension where Japanese patients with TD received once-daily 40- or 80-mg valbenazine. We compared the change from baseline in Abnormal Involuntary Movement Scale total score and Clinical Global Impression of TD score between patients with SCHZ and those with MOOD, and incidence of treatment-emergent adverse events.

Results
Of 256 patients included in the placebo-controlled period, 211 continued to the long-term extension. The mean change from baseline in Abnormal Involuntary Movement Scale total score at week 6 (95% confidence interval) was −1.8 (−3.2 to −0.5) and −3.3 (−4.7 to −1.9) in the valbenazine 40- and 80-mg groups, respectively (SCHZ group), and −2.4 (−3.9 to −0.9) and −3.5 (−5.1 to −1.9) in the valbenazine 40- and 80-mg groups, respectively (MOOD group), demonstrating improvement at either dose level over placebo, regardless of the underlying disease. These results were maintained to week 48, and improvements of Clinical Global Impression of TD scores were similar. There were no notable differences in the incidence of serious or fatal treatment-emergent adverse events by underlying disease; differences in the incidence of worsening schizophrenia and depression were attributed to underlying disease progression.

Conclusions
Safety and efficacy of long-term valbenazine therapy for TD did not vary according to underlying psychiatric disease.
“I Hate Sim!”—Using Psychotherapeutic Concepts to Help Educators Attend to Challenging States of Mind During Simulation Prebriefs
Authors: Drake Gareth , Drewek Katherine 
Published: February 2024

Summary Statement
This article outlines the theoretical development of an approach to simulation prebriefing that we have adopted at Great Ormond Street Children's Hospital. Many educators struggle with anxious or reticent learners during simulation. This reticence often becomes apparent first during the simulation prebrief. Previous work highlights key points to cover in a prebrief. Less work has been done on the dilemma of how to engage such learners while also attempting to maintain a pedagogically effective stance for the entire group. This article pulls together current best practice guidance on prebriefing before exploring pertinent concepts from psychotherapeutic and pedagogical domains—the therapeutic setting, the therapeutic stance, and epistemic trust—which we believe can usefully and practically be applied to simulation practice in the service of engaging reticent learners while enhancing the psychological safety of both learners and educators.
Single Testicular Biopsy: Changes in the vascular architecture of the tunica albuginea
Authors: Oliveira Filho Antonio Barbosa de , Peruquetti Rita Luiza , Rasmussen Lucas Trevizani , Cesar Marcos Teixeira , Cêntola Crescêncio Alberto Pereira , Cedenho Agnaldo Pereira 
Published: February 2024

AbstractOpen testicular biopsy is a commonly indicated procedure for diagnosis of testicular histopathology prior to referral to testicular sperm extraction (TESE) or microsurgical testicular sperm extraction (M-TESE) in men with non-obstructive azoospermia (NOA). There are known hematological changes resulting from the rupture of the blood–testis barrier in the TESE and M-TESE procedures, but changes to the microvasculature have not yet been described when the open biopsy is performed prior to spermatozoid collection for intracytoplasmic sperm injection. In this experimental study, open biopsy was performed on testes from adult rabbits. After a 45 days recovery period, the animals underwent a laparotomy for the surgical removal of the aortic patch, both gonadal arteries, the vasa deferentia, and both testicles. The laparotomy was followed by an angiography. The comparative results demonstrate a breakdown in the vascularization of the testicles biopsied relative to the microvasculature pattern of the tunicae albugineae of the intact testicles. The vascular damage resulting from open testicular biopsy reflects one more negative impact on spermatogenic function of previously lesioned testicles besides the known alterations (fibrosis, decrease in testosterone levels, hematological changes). Therefore, we suggest that the M-TESE should be the choice method for sperm retrieval in men with NOA and it should be planned and performed with simultaneous diagnostic and therapeutic objectives in order to increase the patient’s chances of reproductive success.