bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic/circadian clocks and PCOS
Authors: Vatier Camille , Christin-Maitre Sophie 
Published: April 2024

Abstract
Polycystic ovary syndrome (PCOS) affects 6–20% of reproductive-aged women. It is associated with increased risks of metabolic syndrome, Type 2 diabetes, cardiovascular diseases, mood disorders, endometrial cancer and non-alcoholic fatty liver disease. Although various susceptibility loci have been identified through genetic studies, they account for ∼10% of PCOS heritability. Therefore, the etiology of PCOS remains unclear. This review explores the role of epigenetic changes and modifications in circadian clock genes as potential contributors to PCOS pathogenesis. Epigenetic alterations, such as DNA methylation, histone modifications, and non-coding RNA changes, have been described in diseases related to PCOS, such as diabetes, cardiovascular diseases, and obesity. Furthermore, several animal models have illustrated a link between prenatal exposure to androgens or anti-Müllerian hormone and PCOS-like phenotypes in subsequent generations, illustrating an epigenetic programming in PCOS. In humans, epigenetic changes have been reported in peripheral blood mononuclear cells (PBMC), adipose tissue, granulosa cells (GC), and liver from women with PCOS. The genome of women with PCOS is globally hypomethylated compared to healthy controls. However, specific hypomethylated or hypermethylated genes have been reported in the different tissues of these women. They are mainly involved in hormonal regulation and inflammatory pathways, as well as lipid and glucose metabolism. Additionally, sleep disorders are present in women with PCOS and disruptions in clock genes’ expression patterns have been observed in their PBMC or GCs. While epigenetic changes hold promise as diagnostic biomarkers, the current challenge lies in distinguishing whether these changes are causes or consequences of PCOS. Targeting epigenetic modifications potentially opens avenues for precision medicine in PCOS, including lifestyle interventions and drug therapies. However, data are still lacking in large cohorts of well-characterized PCOS phenotypes. In conclusion, understanding the interplay between genetics, epigenetics, and circadian rhythms may provide valuable insights for early diagnosis and therapeutic strategies in PCOS in the future.
Conditional Effects of the Spotlight: Electoral Institutions and the Enforcement of Global Corporate Norms
Authors: Lee Boram 
Published: April 2024

Abstract
Under what conditions do governments discipline powerful multinational companies for breaching global corporate norms? Existing international relations theories have shown that peer monitoring and transnational advocacy are crucial strategies that shine a spotlight on norm violations. Despite the importance of those strategies, governments in the Global North have not consistently condemned their home-grown multinational companies for breaking norms related to climate or human rights in the Global South. This paper argues that the effect of such spotlighting is crucially moderated by electoral institutions, and legislators in proportional representation systems are more likely than those in majoritarian systems to push multinational companies to comply with global norms when such issues are in the spotlight. I find supporting evidence from the OECD Guidelines’ Specific Instance process and case studies. This article shows that traditional strategies to promote norm compliance, such as transnational advocacy and peer pressure, work differently in different countries, and electoral systems in the Global North can have unintended distributional consequences for norm beneficiaries.
Negative association between host plant suitability and the fitness cost of resistance to Bacillus thuringiensis (Bacillales: Bacillaceae)
Authors: Carrière Yves , Tabashnik Bruce E 
Published: April 2024

Abstract
Transgenic crops producing Bacillus thuringiensis (Bt) toxins are commonly used for controlling insect pests. Nearby refuges of non-Bt host plants play a central role in delaying the evolution of resistance to Bt toxins by pests. Pervasive fitness costs associated with resistance, which entail lower fitness of resistant than susceptible individuals in refuges, can increase the ability of refuges to delay resistance. Moreover, these costs are affected by environmental factors such as host plant suitability, implying that manipulating refuge plant suitability could improve the success of the refuge strategy. Based on results from a previous study of Trichoplusia ni resistant to Bt sprays, it was proposed that low-suitability host plants could magnify costs. To test this hypothesis, we investigated the association between host plant suitability and fitness costs for 80 observations from 30 cases reported in 18 studies of 8 pest species from 5 countries. Consistent with the hypothesis, the association between plant suitability and fitness cost was negative. With plant suitability scaled to range from 0 (low) to 1 (high), the expected cost was 20.7% with a suitability of 1 and the fitness cost increased 2.5% for each 0.1 decrease in suitability. The most common type of resistance to Bt toxins involves mutations affecting a few types of midgut proteins to which Bt toxins bind to kill insects. A better understanding of how such mutations interact with host plant suitability to generate fitness costs could be useful for enhancing the refuge strategy and sustaining the efficacy of Bt crops.
Cytoskeleton remodeling: a central player in plant–fungus interactions
Authors: Sinha Jyotsna , Singh Yeshveer , Verma Praveen Kumar 
Published: April 2024

Abstract
The eukaryotic cytoskeleton is a complex scaffold consisting of actin filaments, intermediate filaments, and microtubules. Although fungi and plants lack intermediate filaments, their dynamic structural network of actin filaments and microtubules regulates cell shape, division, polarity, and vesicular trafficking. However, the specialized functions of the cytoskeleton during plant–fungus interactions remain elusive. Recent reports demonstrate that the plant cytoskeleton responds to signal cues and pathogen invasion through remodeling, thereby coordinating immune receptor trafficking, membrane microdomain formation, aggregation of organelles, and transport of defense compounds. Emerging evidence also suggests that cytoskeleton remodeling further regulates host immunity by triggering salicylic acid signaling, reactive oxygen species generation, and pathogenesis-related gene expression. During host invasion, fungi undergo systematic cytoskeleton remodeling, which is crucial for successful host penetration and colonization. Furthermore, phytohormones act as an essential regulator of plant cytoskeleton dynamics and are frequently targeted by fungal effectors to disrupt the host’s growth–defense balance. This review discusses recent advances in the understanding of cytoskeleton dynamics during plant–fungus interactions and provides novel insights into the relationship between phytohormones and cytoskeleton remodeling upon pathogen attack. We also highlight the importance of fungal cytoskeleton rearrangements during host colonization and suggest directions for future investigations in this field.
Attack principles in sequent-based argumentation theory
Authors: Corsi Esther Anna 
Published: April 2024

Abstract
Attack principles have been introduced in semi-abstract argumentation frameworks and, in the present work, we interpret them in sequent-based argumentation frameworks. Thus, we investigate the role of minimality and consistency of the support set of an argument. Through the notion of preservation of strength, we introduce a formal criterion to sort out the attack principles; isolate the more “acceptable” ones, i.e. those easier to justify; and recover a new argumentative semantics for the non-classical logic that arises from dropping the rules $(\neg , r)$, $(\land , r)$ and $(\supset , l)$ from Gentzen’s classical sequent calculus for classical logic $\textsf{LK}$.
“I Knew Then Who I Was. I Was a Negro”: Black Armed Defense in Walter White’s A Man Called White
Authors: Chaney Michael 
Published: April 2024

Abstract
This essay investigates literary and autobiographical representations of the defense of Black-owned property in the face of anti-Black mob violence during the first decades of the twentieth century. In his autobiography, A Man Called White (1948), NAACP leader Walter White represents guns as desperate tools of an always tenuous security marked by the violence of the world wars, lynchings, and racially motivated massacres. The backdrop for these struggles is woven from White’s youth amid terrifying events that will later come to be known as the Atlanta “race riot” of 1906. Repeating those events in his autobiography, White unmasks the juridical and sociopolitical order of its civilizing appurtenances and invokes the gun as a symbol of Black armed self-defense. In White’s autobiography, even as guns are used to enforce anti-Blackness they may yet be turned against the white mob to secure Black lives at the local level and turned into legal arguments by a Black collective at the national level via an organization such as the NAACP.
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome
Authors: Tanaka Tsurugi , Urata Yoko , Harada Miyuki , Kunitomi Chisato , Kusamoto Akari , Koike Hiroshi , Xu Zixin , Sakaguchi Nanoka , Tsuchida Chihiro , Komura Airi , Teshima Ayaka , Takahashi Nozomi , Wada-Hiraike Osamu , Hirota Yasushi , Osuga Yutaka 
Published: April 2024

Abstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, but its pathology has not been fully characterized and the optimal treatment strategy remains unclear. Cellular senescence is a permanent state of cell-cycle arrest that can be induced by multiple stresses. Senescent cells contribute to the pathogenesis of various diseases, owing to an alteration in secretory profile, termed ‘senescence-associated secretory phenotype’ (SASP), including with respect to pro-inflammatory cytokines. Senolytics, a class of drugs that selectively eliminate senescent cells, are now being used clinically, and a combination of dasatinib and quercetin (DQ) has been extensively used as a senolytic. We aimed to investigate whether cellular senescence is involved in the pathology of PCOS and whether DQ treatment has beneficial effects in patients with PCOS. We obtained ovaries from patients with or without PCOS, and established a mouse model of PCOS by injecting dehydroepiandrosterone. The expression of the senescence markers p16INK4a, p21, p53, γH2AX, and senescence-associated β-galactosidase and the SASP-related factor interleukin-6 was significantly higher in the ovaries of patients with PCOS and PCOS mice than in controls. To evaluate the effects of hyperandrogenism and DQ on cellular senescence in vitro, we stimulated cultured human granulosa cells (GCs) with testosterone and treated them with DQ. The expression of markers of senescence and a SASP-related factor was increased by testosterone, and DQ reduced this increase. DQ reduced the expression of markers of senescence and a SASP-related factor in the ovaries of PCOS mice and improved their morphology. These results indicate that cellular senescence occurs in PCOS. Hyperandrogenism causes cellular senescence in GCs in PCOS, and senolytic treatment reduces the accumulation of senescent GCs and improves ovarian morphology under hyperandrogenism. Thus, DQ might represent a novel therapy for PCOS.
The effect of capacity constraints on the slope of the Phillips curve
Authors: Holm Martin B , Lerdalen Lars O , Vines David 
Published: April 2024

Abstract
How do capacity constraints affect the slope of the Phillips curve? In particular, do changes in output affect prices by more when firms face more strongly diminishing returns? Intuitively, one may conjecture that the answer is yes. With more strongly diminishing returns, marginal costs increase more when production increases, also raising prices by more. But this intuition is incomplete in models with sticky prices à la Calvo. In the standard New Keynesian model with Calvo pricing frictions, more strongly diminishing returns actually flatten the Phillips curve. The reason is the reluctance of firms who alter their prices to let their prices get too far out of line with the prices set by firms that do not adjust. We explain how the Phillips curve might be amended to avoid this implausible feature, for example, by using Rotemberg pricing or introducing wage stickiness.
Framing contestation and public influence on policymakers: evidence from US artificial intelligence policy discourse
Authors: Schiff Daniel S 
Published: April 2024

Abstract
As artificial intelligence (AI) policy has begun to take shape in recent years, policy actors have worked to influence policymakers by strategically promoting issue frames that define the problems and solutions policymakers should attend to. Three such issue frames are especially prominent, surrounding AI’s economic, geopolitical, and ethical dimensions. Relatedly, while technology policy is traditionally expert-dominated, new governance paradigms are encouraging increased public participation along with heightened attention to social and ethical dimensions of technology. This study aims to provide insight into whether members of the public and the issue frames they employ shape—or fail to shape—policymaker agendas, particularly for highly contested and technical policy domains. To assess this question, the study draws on a dataset of approximately five million Twitter messages from members of the public related to AI, as well as corresponding AI messages from the 115th and 116th US Congresses. After using text analysis techniques to identify the prevalence of issue frames, the study applies autoregressive integrated moving average and vector autoregression modeling to determine whether issue frames used by the public appear to influence the subsequent messaging used by federal US policymakers. Results indicate that the public does lead policymaker attention to AI generally. However, the public does not have a special role in shaping attention to ethical implications of AI, as public influence occurs only when the public discusses AI’s economic dimensions. Overall, the results suggest that calls for public engagement in AI policy may be underrealized and potentially circumscribed by strategic considerations.
Who engages whom?—Deficit communication in participatory science governance as democratic deficit
Authors: Maia Loureiro Paulo , Horta Hugo 
Published: April 2024

Abstract
This article builds on the evolving relationship between science and society, focusing on the increasing emphasis on public participation in science decision-making processes. Public participation in science is often regarded as an embodiment of democratic principles that grant citizens the opportunity to engage with and influence scientific and technological developments. However, deficit models of science communication in participatory governance may be turning into democratic deficits. This article critically examines the deficit model of science communication, highlighting its potential democratic deficit. Drawing on empirical evidence from two case studies in a rural, socio-economically underdeveloped region in Portugal, the authors analyse the dynamics between agency and structure in hierarchical decision-making structures and power relations. We recommend policy implications to enhance the democratic quality of participatory science governance processes, based on convergence of initiatives, transparency, and new prospects for science communication.
Feeding pattern in preterm neonates admitted in neonatology unit: a descriptive cross-sectional study
Authors: Kiran Sneha , Bhatta Mukesh , Bhatta Nisha K. , Yadav Shankar P. , Subedi Rejeena , Shah Abhishek 
Published: April 2024

Background:
The components of breast feeding including sucking, swallowing, and breathing, develop at different gestational ages, and are incomplete in preterm. Other modes of feeding like nasogastric/orogastric and cup are used till matured breast feeding skills appear.

Material and methods:
This descriptive cross-sectional study was done over a period of 1 year with objectives to observe the different feeding patterns in the preterm neonates, assess the time required to start feeding from the day of admission, and observe the time taken for transition from one feeding pattern to another feeding pattern. A total of 116 admitted preterm neonates born less than 34 weeks were included. The ethical clearance and informed consent were obtained. The time of admission, the duration between the time of admission and start of feeding, type of feeding, mode of feeding, and progression of feeding from one mode to another was noted, and appropriate statistical analysis done.

Results:
Cup feeding (57.8%) was the most common mode of starting of feeding followed by orogastric feeding (42.2%). Mothers breast milk was the most common feed. The median duration of starting of feed from the day of admission was 2 days. The time gap between day of admission and starting of orogastric feed and cup feeding were 2 days and 5 days, respectively. The median time taken for transition from orogastric feed to cup feed and from cup feed to mothers breast feed was 5 days and 6 days, respectively. Babies with a higher age at starting of feeding took significantly lesser time to transit from cup feeding to mother’s breast feeding (P=0.01). Babies with Respiratory Distress Syndrome had a significantly higher transit time from orogastric feeding to cup feeding (P<0.001).

Conclusion:
The rate of advancement of feed depends on maturation of feeding skills, gestational age, birth weight, presence of comorbidities, and nursing care.
Previously unrecognized Morgagni’s hernia presenting with bowel obstruction: a rare case report
Authors: Slimi Youness , Mahmoudi Mohammed , Frikal Mohammed , Derkaoui Anas , Deflaoui Tarik , Jabi Rachid , Bouziane Mohammed 
Published: April 2024

Introduction and importance:
Morgagni’s hernia (MH) is a rare entity, it is defined by the protrusion of abdominal viscera through an anterior retrosternal diaphragmatic defect. It is mainly diagnosed during the perinatal and neonatal periods. A few cases have been reported in adults. The objective of this study was to report the case of a patient with an unrecognized MH, review the current literature on Morgani hernias in the adult population, and assess their clinical characteristics and therapeutic approach reported in adults. We here describe a rare case of a MH presenting with bowel obstruction as the primary symptom in adult life.

Case presentation:
A 52-year-old man presented to the emergency department with a bowel obstruction. The abdominal CT tomography showed an intestinal bowel obstruction above the hiatal hernia with an intrathoracic ascending colon. Exploratory laparotomy revealed a bilateral strangulated diaphragmatic hernia of Morgagni. The patient underwent closure of the diaphragmatic defect under tension by X-stitch. The recovery was uneventful, and the patient is in good health after 12 months of follow-up.

Clinical discussion:
The Morgagni hernias are usually asymptomatic; complications such as strangulation of the herniated colon or herniated stomach by stricture are exceptional. Surgical treatment is always recommended for MH. Postoperative complications are rare in simple diaphragmatic hernias, and the course is generally favorable.

Conclusion:
MH is the rarest form of congenital diaphragmatic hernia, with nonspecific symptomatology contributing to the delay in diagnosis. The cure is surgical, and the open surgical approach is preferable in emergency cases, while laparoscopic surgery is favored in elective settings and is associated with shorter hospitalization. Further studies are crucial in order to elucidate etiology and optimal therapeutic approach.
The fulfilled promise and unmet potential of umbilical cord blood
Authors: Ropa James , Van’t Hof Wouter 
Published: April 2024

Purpose of review
Here, we review classic and emerging uses of umbilical cord blood and highlight strategies to improve its utility, focusing on selection of the appropriate units and cell types for the intended applications.

Recent literature
Recent studies have shown advancements in cord blood cell utility in a variety of cellular therapies and have made strides in elucidating manners to select the best units for therapy and target new ways to improve the various cell subpopulations for their respective applications.

Summary
Umbilical cord blood is a proven source of cells for hematopoietic cell transplantation and research and is an important potential source for additional cellular therapies. However, cord blood utility is limited by low “doses” of potent cells that can be obtained from individual units, a limitation that is specific to cord blood as a donor source. In addition to traditional CD34+ progenitor cells, cord blood lymphocytes are being pursued as therapeutic entities with their own unique properties and characteristics. Thus, selection of ideal units depends on the intended therapeutic entity and target, and identification of differential potency parameters is critical to drive effective banking strategies accommodating successful clinical use of cord blood in broader cell therapy settings.
Combined Transcranial Doppler and Melatonin Levels to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
Authors: Su Yan , Cao Yonggui , Zang Haoran , Gao Wuzhou , Liu Xuewu , Li Fuqing , An Qingming , Dai Zhicheng 
Published: April 2024

Objective:
To investigate the early prediction value of transcranial Doppler ultrasound (TCD) combined with serum melatonin level for delayed cerebral ischemia (DCI) caused by subarachnoid hemorrhage (SAH).

Methods:
This paper is a prospective study. A total of 120 patients with SAH treated were included. The patients were divided into the DCI group (40 cases) and non-DCI group (80 cases) according to whether DCI occurred 14 days after SAH (DCI usually occurs 4 to 14 d after bleeding). Baseline data, serum melatonin level, and TCD test results within 24 hours after admission were compared between the 2 groups. Multivariate logistic analysis was used to analyze the factors affecting the occurrence of DCI after SAH. The value of serum melatonin level, middle cerebral artery mean blood flow velocity (MBFV) and their combination in predicting DCI in SAH patients was evaluated.

Results:
Univariate analysis showed that there were statistically significant differences in the proportion of Fisher grade, Hunt-Hess grade, serum melatonin level, middle cerebral artery systolic blood flow velocity (Vs), MBFV and pulse index (PI) between the 2 groups (P<0.05). Serum melatonin levels, middle cerebral artery Vs, MBFV, and PI in the DCI group were higher than those in non-DCI group. Logistic regression (LR) analysis showed that serum melatonin level (OR=1.796, 95% CI: 1.575-4.123) and middle cerebral artery MBFV (OR=3.279, 95% CI: 2.112-4.720] were the influencing factors for DCI in SAH patients (P<0.05).

Conclusion:
Middle cerebral artery MBFV and serum melatonin levels were higher in patients with SAH complicated with DCI, and the combination of the 2 could provide a reference for early clinical prediction of DCI in patients with aneurysmal subarachnoid hemorrhage (aSAH).