bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revolutionizing the workplace: A case study of the future of work program at Capital One
Authors: Khanna Shilpa , New J. Randolph 
Published: November 2008

AbstractToday's workplace designs are being revolutionized due to the changing nature of work and worker profiles, the impact of technology, and the need for organizational efficiency and flexibility. Our case study of the Future of Work (FOW) program at Capital One highlights how thoughtful segmentation of work styles, supportive HR policy, customized workplace design, and the optimal use of technology can enhance knowledge work. FOW results show clear success in terms of increased employee satisfaction leading to improved organizational performance along with better real estate asset utilization and flexibility. To assist HR leaders and planners, we suggest a practical model that shows the impact of workplace design requirements on employee behavior and ultimately on organizational outcomes. © 2008 Wiley Periodicals, Inc.
Evaluation of global optimization algorithms for parameter calibration of a computationally intensive hydrologic model
Authors: Zhang Xuesong , Srinivasan Raghavan , Zhao Kaiguang , Liew Mike Van 
Published: November 2008

AbstractWith the popularity of complex hydrologic models, the time taken to run these models is increasing substantially. Comparing and evaluating the efficacy of different optimization algorithms for calibrating computationally intensive hydrologic models is becoming a nontrivial issue. In this study, five global optimization algorithms (genetic algorithms, shuffled complex evolution, particle swarm optimization, differential evolution, and artificial immune system) were tested for automatic parameter calibration of a complex hydrologic model, Soil and Water Assessment Tool (SWAT), in four watersheds. The results show that genetic algorithms (GA) outperform the other four algorithms given model evaluation numbers larger than 2000, while particle swarm optimization (PSO) can obtain better parameter solutions than other algorithms given fewer number of model runs (less than 2000). Given limited computational time, the PSO algorithm is preferred, while GA should be chosen given plenty of computational resources. When applying GA and PSO for parameter optimization of SWAT, small population size should be chosen. Copyright © 2008 John Wiley & Sons, Ltd.
Consistency between hydrological models and field observations: linking processes at the hillslope scale to hydrological responses at the watershed scale
Authors: Clark M. P. , Rupp D. E. , Woods R. A. , Tromp‐van Meerveld H. J. , Peters N. E. , Freer J. E. 
Published: November 2008

AbstractThe purpose of this paper is to identify simple connections between observations of hydrological processes at the hillslope scale and observations of the response of watersheds following rainfall, with a view to building a parsimonious model of catchment processes. The focus is on the well‐studied Panola Mountain Research Watershed (PMRW), Georgia, USA. Recession analysis of discharge Q shows that while the relationship between dQ/dt and Q is approximately consistent with a linear reservoir for the hillslope, there is a deviation from linearity that becomes progressively larger with increasing spatial scale. To account for these scale differences conceptual models of streamflow recession are defined at both the hillslope scale and the watershed scale, and an assessment made as to whether models at the hillslope scale can be aggregated to be consistent with models at the watershed scale.Results from this study show that a model with parallel linear reservoirs provides the most plausible explanation (of those tested) for both the linear hillslope response to rainfall and non‐linear recession behaviour observed at the watershed outlet. In this model each linear reservoir is associated with a landscape type. The parallel reservoir model is consistent with both geochemical analyses of hydrological flow paths and water balance estimates of bedrock recharge. Overall, this study demonstrates that standard approaches of using recession analysis to identify the functional form of storage–discharge relationships identify model structures that are inconsistent with field evidence, and that recession analysis at multiple spatial scales can provide useful insights into catchment behaviour. Copyright © 2008 John Wiley & Sons, Ltd.
Glycosaminoglycans modulate inflammation and apoptosis in LPS‐treated chondrocytes
Authors: Campo Giuseppe M. , Avenoso Angela , Campo Salvatore , D'Ascola Angela , Traina Paola , Samà Dario , Calatroni Alberto 
Published: November 2008

AbstractPrevious studies reported that hyaluronic acid (HA), chondroitin sulphate (CS) and heparan sulphate (HS) were able to reduce the inflammatory process in a variety of cell types after lypopolysaccharide (LPS) stimulation. The aim of this study was to investigate the anti‐inflammatory effect of glycosaminoglycans (GAGs) in mouse articular chondrocytes stimulated with LPS. Chondrocyte treatment with LPS (50 µg/ml) generated high levels of TNF‐α, IL‐1β, IL‐6, IFN‐γ, MMP‐1, MMP‐13, iNOS gene expression and their related proteins, increased NO concentrations (evaluated in terms of nitrites formation), NF‐κB activation and IkBα degradation as well as apoptosis evaluated by the increase in caspase‐3 expression and the amount of its related protein. The treatment of chondrocytes using two different doses (0.5 and 1.0 mg/ml) of HA, chondroitin‐4‐sulphate (C4S), chondroitin‐6‐sulphate (C6S), HS, keratan sulphate (KS) and dermatan sulphate (DS) produced a number of effects. HA exerted a very small anti‐inflammatory and anti‐apoptotic effect while it significantly reduced NO levels, although the effect on iNOS expression and activity was extremely slight. C4S and C6S reduced inflammation mediators and the apoptotic process. C6S failed to decrease NO production, although iNOS expression and activity were significantly reduced. HS, like C4S, was able to reduce all the effects stimulated by LPS treatment. KS and DS produced no reduction in any of the parameters considered. These results give further support to the hypothesis that GAGs actively participate in the regulation of inflammatory and apoptotic processes. J. Cell. Biochem. 106: 83–92, 2009. © 2008 Wiley‐Liss, Inc.
Matrix vesicles originate from apical membrane microvilli of mineralizing osteoblast‐like Saos‐2 cells
Authors: Thouverey Cyril , Strzelecka‐Kiliszek Agnieszka , Balcerzak Marcin , Buchet René , Pikula Slawomir 
Published: November 2008

AbstractIn bone, mineralization is tightly regulated by osteoblasts and hypertrophic chondrocytes which release matrix vesicles (MVs) and control extracellular ionic conditions and matrix composition. MVs are the initial sites of hydroxyapatite (HA) mineral formation. Despite growing knowledge about their morphology and function, their biogenesis is not well understood. The purpose of this work was to determine the source of MVs in osteoblast lineage, Saos‐2 cells, and to check whether MVs originated from microvilli. Microvilli were isolated from the apical plasma membrane of Saos‐2 cells. Their morphology, structure, and function were compared with those of MVs. The role of actin network in MV release was investigated by using microfilament perturbing drugs. When examined by electron microscopy MVs and microvillar vesicles were found to exhibit similar morphology with trilaminar membranes and diameters in the same range. Both types of vesicles were able to induce HA formation. Their electrophoretic profiles displayed analogous enrichment in alkaline phosphatase, Na+/K+ ATPase, and annexins A2 and A6. MVs and microvillar vesicles exhibited almost the same lipid composition with a higher content of cholesterol, sphingomyelin, and phosphatidylserine as compared to plasma membrane. Finally, cytochalasin D, which inhibits actin polymerization, was found to stimulate release of MVs. Our findings were consistent with the hypothesis that MVs originated from cell microvilli and that actin filament disassembly was involved in their biogenesis. J. Cell. Biochem. 106: 127–138, 2009. © 2008 Wiley‐Liss, Inc.
On the nature of the π → π* ionic excited states: The V state of ethene as a prototype
Authors: Angeli Celestino 
Published: November 2008

AbstractThis article addresses an analysis of the physical effects required for the correct description of the ionic π → π* excited states in the frame of ab initio quantum chemistry, using the ionic V state of the ethene molecule as an example. The importance of the dynamic σ polarization (absent in methods where the σ skeleton is treated at a mean‐field level) has been recognized by many authors in the past. In this article a new physical effect is described, i.e. the spatial contraction of the π and π* molecular orbitals (or of the local p atomic orbitals) originated from the reduction of the ionicity due to the dynamic σ polarization. Such an effect is a second‐order effect (it appears only as a consequence of the dynamic σ polarization) but it cannot be ignored. Many of the difficulties found in the past in the calculation of the vertical excitation energy of the ionic states are attributed to an incomplete description of this contraction, while the few successes have been obtained when it has been fortuitously introduced by ad hoc procedures or when it is described in a brute force approach. Various strategies are proposed to allow for the spatial contraction of the p atomic orbitals. If this effect is considered at the orbital optimization step, it is shown that for the V state of ethene no Rydberg/valence mixing occurs and a simple perturbation correction (to the second order in the energy) on the π → π* singly excited configuration gives stable results with respect to the computational parameters and in good agreement with the experimental findings and with the best theoretical calculations. Moreover, our results confirm the indication of Müller et al. (J Chem Phys 1999, 110, 7176) that the transition to the V state of ethene conforms to the Franck‐Condon principle and that it is not necessary to appeal to a nonvertical transition to interpret the experimental data. The strategy reported in this article for ethene can be in principle generalized to the π → π* ionic excited states of other molecules. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2009
The Meissner and Pacinian sensory corpuscles revisited new data from the last decade
Authors: Vega José A. , García‐Suárez Olivia , Montaño Juan A. , Pardo Berta , Cobo Juan M. 
Published: November 2008

AbstractThis article reviews the biochemical, physiological, and experimental data cumulated during the last decade on the Meissner and Pacinian corpuscles. It includes information about (i) the localization of molecules recently detected in sensory corpuscles; (ii) the unsolved problem of the accessory fibers in sensory corpuscles and the occurrence of myelin within them; (iii) the development of sensory corpuscles, especially their neuronal and growth factor dependency; (iv) the composition and functional significance of the extracellular matrix as an essential part of the mechanisms involved in the genesis of the stimuli generated in sensory corpuscles; (v) the molecular basis of mechanotransduction; (vi) a miscellaneous section containing sparse new data on the protein composition of sensory corpuscles, as well as in the proteins involved in live–death cell decisions; (vii) the changes in sensory corpuscles as a consequence of aging, the central, or peripheral nervous system injury; and finally, (viii) the special interest of Meissner corpuscles and Pacinian corpuscles for pathologists for the diagnosis of some peripheral neuropathies and neurodegenerative diseases. Microsc. Res. Tech., 2009. © 2008 Wiley‐Liss, Inc.
One Pot Synthesis of Surface PEGylated Core–Shell Microparticles by Suspension Polymerization with Surface Enrichment of Biotin/Avidin Conjugation
Authors: Ting S. R. Simon , Nguyen T. L. Uyen , Stenzel Martina H. 
Published: November 2008

AbstractCore–shell microparticles that consist of poly(vinyl neodecanoate) (VND) crosslinked with poly(ethylene glycol dimethacrylate) (EGDMA) as the core and poly(ethylene glycol methacrylate) (PEGMA) ($\overline M _{\rm n}$ = 360 or $\overline M _{\rm n}$ = 526 g · mol−1) as the shell have been synthesized using suspension polymerization by a conventional free radical polymerization process. Interfacial tension and stability tests show that PEGMA acts as an amphiphilic macromonomer and is located on the oil/water interface of the suspension system, thus forming an outer layer during the polymerization. Kinetic studies of the monomers' conversion of VND, EGDMA, and PEGMA have been carried out using 1H NMR spectroscopy. EGDMA and PEGMA were found to have faster reaction rates compared to VND. Moreover, scanning electron microscopy showed that the polymerization of these particles starts from the shell and finishes towards the core. Consequently, the resulting microsphere is found to have a multi‐layer structure. Biotin was covalently bound to the surface by the PEGMA hydroxy groups. Conjugation of biotin with streptavidin PE (phycoerythrin) was subsequently carried out. Confocal microscopy was used to confirm the presence of fluorescing streptavidin. The amount of avidin conjugated to the microspheres was calculated by the release of a 2‐(4‐hydroxyphenylazo)benzoic acid/avidin complex using UV/vis spectroscopy. One avidin molecule was found to occupy 7 nm2 on the surface of the microspheres.magnified image
Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis
Authors: Huang Xinqiang , Yang Chaofeng , Jin Chengliu , Luo Yongde , Wang Fen , McKeehan Wallace L 
Published: November 2008

AbstractFibroblast growth factor (FGF) family signaling mediates cell‐to‐cell communication in development and organ homeostasis in adults. Of the FGF receptor (FGFR) isotypes, FGFR4 is the sole resident isotype present in mature parenchymal hepatocytes. FGFR1 that is normally associated with activated nonparenchymal cells appears ectopically in hepatoma cells. Ectopic expression and chronic activity of FGFR1 in hepatocytes accelerates diethylnitrosamine (DEN)‐initiated hepatocarcinogenesis by driving unrestrained cell proliferation and tumor angiogenesis. Hepatocyte FGFR4 mediates liver's role in systemic cholesterol/bile acid and lipid metabolism and affects proper hepatolobular restoration after damage without effect on cell proliferation. Here we ask whether FGFR4 plays a role in progression of hepatocellular carcinoma (HCC). We report that although spontaneous HCC was not detected in livers of FGFR4‐deficient mice, the ablation of FGFR4 accelerated DEN‐induced hepatocarcinogenesis. In contrast to FGFR1 that induced a strong mitogenic response and depressed rate of cell death in hepatoma cells, FGFR4 failed to induce a mitogenic response and increased the rate of cell death. FGFR1 but not FGFR4 induced cyclin D1 and repressed p27 expression. Analysis of activation of Erk, JNK, and PI3K‐related AKT signaling pathways indicated that in contrast to FGFR1, FGFR4 failed to sustain Erk activation and did not activate AKT. These differences may underlie the opposing effects of FGFR1 and FGFR4. These results suggest that in contrast to ectopic FGFR1 that is a strong promoter of hepatoma, resident FGFR4 that mediates differentiated hepatocyte metabolic functions also serves to suppress hepatoma progression. © 2008 Wiley‐Liss, Inc.
Optimal monopoly market area spanning in multidimensional commodity spaces
Authors: Péli Gábor , van Witteloostuijn Arjen 
Published: November 2008

AbstractA monopoly firm locates in multidimensional product characteristics' space by setting a price that maximizes its profits. The monopoly market area (MMA) it serves strikes the happy medium between lower price and larger MMA, assuming absence of price discrimination, by setting the price at the MMA margins. The MMA takes different shapes, such as hyperspheres or hypercubes, depending on how customers perceive the product distance from their ideal tastes. Commodity space dimensionality, a measure of customer taste elaboration, has a robust effect on optimization: the optimal MMA stretch increases and price decreases with dimensionality, with different customer sensitivity patterns in place. Copyright © 2008 John Wiley & Sons, Ltd.
Clinical and pathological characteristics of patients with Leucine‐rich repeat kinase‐2 mutations
Authors: Covy Jason P. , Yuan Wuxing , Waxman Elisa A. , Hurtig Howard I. , Van Deerlin Vivianna M. , Giasson Benoit I. 
Published: November 2008

AbstractMutations in LRRK2 are the single most common known cause of Parkinson's disease (PD). Two new PD patients with LRRK2 mutation were identified from a cohort with extensive postmortem assessment. One of these patients harbors the R793M mutation and presented with the typical clinical and pathological features of PD. A novel L1165P mutation was identified in a second patient. This patient had the classical and pathological features of PD, but additionally developed severe neuropsychological symptoms and dementia associated with abundant neurofibrillary tangles in the hippocampal formation; features consistent with a secondary diagnosis of tangle‐predominant dementia. α‐Synuclein‐containing pathological inclusions in these patients also were highly phosphorylated at Ser‐129, similar to other patients with idiopathic PD. These two PD patients also were characterized by the presence of occasional cytoplasmic TDP‐43 inclusions in the temporal cortex, a finding that was not observed in three other patients with the G2019S mutation in LRRK2. These findings extend the clinical and pathological features that may be associated with LRRK2 mutations. © 2008 Movement Disorder Society
A novel hereditary spastic paraplegia with dystonia linked to chromosome 2q24‐2q31
Authors: Gilbert Donald L. , Leslie Elizabeth J. , Keddache Mehdi , Leslie Nancy D. 
Published: November 2008

AbstractSpastic paraplegias (HSPs) and dystonias (DYTs) typically localize to different neuroanatomic systems. We report clinical and genetic data from large Ohio kindred with autosomal dominant (AD) HSP and DYT. Single and multipoint linkage using microsatellite and single nucleotide polymorphism array genotyping were performed on a large, multigenerational family with a novel, AD, highly penetrant neurological disease causing spasticity and DYT. Age of onset of spasticity and weakness is from the first year to the sixth decade, and age of onset of DYT from the first to third decade. There is no ataxia or apparent cognitive involvement. Neuroimaging and peripheral neurophysiology are normal. Generalized DYT improved markedly with deep brain stimulation in 1 child. The disease locus was mapped to a region on chromosome 2q 24–31, flanked by markers rs1424937–rs1559510, proximal to SPG13, in a region where there are no known HSP or DYT genes. A secondary analysis for candidate genes segregating with the DYT phenotype revealed two candidate regions with parametric lod scores above 2.0. On the basis of clinical presentation and linkage results, we conclude that this disease is a novel neurological disorder. Identifying the causative gene may elucidate an important pathway for pyramidal and extrapyramidal disorders. © 2008 Movement Disorder Society
Quasi‐lumped design of UMTS diplexer using combined CPW and microstrip
Authors: Xu Wei‐Qin , Ho Min‐Hua , Hsu Chung‐I. G. 
Published: November 2008

AbstractIn this letter, we propose a novel design of a universal mobile telecommunications system diplexer using a combined coplanar waveguide (CPW) and microstrip structure. The diplexer is composed of two bandpass filters (BPFs), which are termed the transmitting (Tx) and receiving (Rx) filters. The filter's characteristics analyzed by a circuit model of the LC lumped elements are implemented using the CPW and microstrip. A transmission zero is implanted for each filter to reject the signal of the other filter's band. The two filters are in a parallel‐cascade layout and a microstrip is used to couple the I/O signals from/to the filters. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 150–152, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23952
Interconnection loss from substrate effects on LNA performance and design accuracy
Authors: Tseng S.‐C. , Meng C. C. , Liao H.‐Y. , Lin Y.‐C. , Teng Y.‐H. 
Published: November 2008

AbstractA 5.2 GHz 0.18‐μm SiGe BiCMOS low noise amplifier is implemented with guided‐wave interconnections in this letter. These interconnections reduce the substrate skin and proximity effects and hence are suitable for high frequency circuits. The guided interconnections bring 1.7‐dB gain and 0.55‐dB noise figure enhancement for the low noise amplifier. In addition, accurate and simple design methodology relies on the complete models of components and interconnections when the postsimulation from the rc extraction is not enough for the high frequency circuit design. The measurement results give excellent agreements with the schematic simulation. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 144–146, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23968
Parametric analysis of Sierpinski‐like fractal patch antenna for compact and dual band WLAN applications
Authors: Li Hui , Khan Salman , Liu Jingxian , He Sailing 
Published: November 2008

AbstractA Sierpinski‐like fractal patch antenna with a slant strip in the first iteration is proposed in this article. The parameters of this kind of antenna are analyzed and optimized for dual WLAN application. The added slant strip provides simple probe feeding for compactness and also helps bandwidth enhancement due to multiple modes, which can be evident from current distribution. Measured return loss below −10 dB is from 2.38–2.45 GHz and 5.17–5.83 GHz, coinciding well with dual band WLAN standard. The boresight gain and radiation pattern in different planes are also presented. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 36–40, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23974
Rigorous mode‐matching analysis of energy tunneling through an ultranarrow epsilon‐near‐zero channel
Authors: Pan Yongmei , Xu Shanjia 
Published: November 2008

AbstractOn the basis of the rigorous mode‐matching procedure, we demonstrate theoretically that electromagnetic waves can be squeezed and tunneled through very narrow channel waveguides at cutoff frequency, which mimics the response of ε‐near‐zero (ENZ) materials. Because of the infinite phase velocity of the wave propagation in ENZ material, this tunneling phenomenon possesses distinct anomalous properties: the phase of the wave along the narrow channel is almost uniform and it is fundamentally independent of its geometry. All of these theoretical predictions agree well with the experimental results. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 163–166, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23994