bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regiospecificity in the Reaction of 2,3‐Dichloronaphthazarins with Azide Anions. Synthesis of Echinamine A — A Metabolite Produced by the Sea Urchin Scaphechinus mirabilis.
Authors: Pokhilo Nataly D. , Yakubovskaya Alla Ya. , Denisenko Vladimir A. , Anufriev Victor Ph. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lindleyanin (I) and Bergapten‐8‐yl Sulfate (II) from Pleurospermum lindleyanum.
Authors: Tan Jun‐Jie , Tan Chang‐Heng , Wang Yong‐Qiang , Jiang Shan‐Hao , Zhu Da‐Yuan 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Concentricolide, an anti‐HIV Agent from the Ascomycete Daldinia concentrica.
Authors: Qin Xiang‐Dong , Dong Ze‐Jun , Liu Ji‐Kai , Yang Liu‐Meng , Wang Rui‐Rui , Zheng Yong‐Tang , Lu Yang , Wu Yun‐Shan , Zheng Qi‐Tai 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Total Syntheses of (‐)‐clasto‐Lactacystin β‐Lactone and 7‐epi‐(‐)‐clasto‐Lactacystin β‐Lactone.
Authors: Hayes Christopher J. , Sherlock Alexandra E. , Selby Matthew D. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Marinomycins A—D, Antitumor‐Antibiotics of a New Structure Class from a Marine Actinomycete of the Recently Discovered Genus “Marinispora”.
Authors: Kwon Hak Cheol , Kauffman Christopher A. , Jensen Paul R. , Fenical William 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Approach to Synthesis of Questiomycin A: Oxidative Cyclocondensation of ortho‐Aminophenol.
Authors: Giurg M. , Wiech E. , Piekielska K. , Gebala M. , Mlochowski J. , Wolanski M. , Ditkowski B. , Peczynska‐Czoch W. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel and Stereocontrolled Asymmetric Synthesis of a New Naturally Occurring Styryllactone, (+)‐Cardiobutanolide.
Authors: Matsuura Daisuke , Takabe Kunihiko , Yoda Hidemi 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of (S)‐Plakolide A and Revision of the Absolute Stereochemistry of the Natural (‐)‐Plakolide A.
Authors: Kanayama Masaru , Nishiwaki Keiji , Matsuo Keizo 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Floresolide B and Δ6,7‐Z‐Floresolide B.
Authors: Nicolaou K. C. , Xu Hao 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Do Ion Tethered Functional Groups Affect IL Solvent Properties? The Case of Sulfoxides and Sulfones.
Authors: Sharma Nawal K. , Tickell Morgan D. , Anderson Jared L. , Kaar Joel , Pino Veronica , Wicker Benjamin F. , Armstrong Daniel W. , Davis James H. Jr. , Russell Alan J. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Chiral Phosphorus Ligands with Spirobiindan Backbone for Asymmetric Hydrogenations
Authors: Xie Jian‐Hua , Zhu Shou‐Fei , Fu Yu , Hu Ai‐Guo , Zhou Qi‐Lin 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Alkylperoxy Sulfonic Acids: Thermostability and Oxidizing Properties
Authors: Safiullin R. L. , Zaripov R. N. , Enikeeva L. R. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metal—Ligand Bifunctional Catalysis for Asymmetric Hydrogenation
Authors: Noyori Ryoji , Sandoval Christian A. , Muniz Kilian , Ohkuma Takeshi 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyclodextrins as Supramolecular Hosts for Organometallic Complexes
Authors: Hapiot F. , Tilloy S. , Monflier E. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vinylic Tellurides: From Preparation to Their Applicability in Organic Synthesis
Authors: Zeni Gilson , Luedtke Diogo S. , Panatieri Rodrigo B. , Braga Antonio L. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Poison Frog Alkaloids: Novel, Potent and Subtype‐Selective Blockers of Neuronal Nicotinic Acetylcholine Receptors
Authors: Toyooka Naoki , Nemoto Hideo , Tsuneki Hiroshi 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Progress in the Pursuit of Therapeutic Adenosine Receptor Antagonists
Authors: Moro Stefano , Gao Zhan‐Guo , Jacobson Kenneth A. , Spalluto Giampiero 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular Activity of Sirolimus and Its Possible Application in Tuberous Sclerosis Treatment
Authors: Jozwiak Jaroslaw , Jozwiak Sergiusz , Oldak Monika 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Functionally‐Substituted Alkoxyethylenes in Reactions with Nucleophiles. Part 2. Synthesis of Noncyclic Structures, Benzene Derivatives, 5‐, 7‐Membered, and Macroheterocycles
Authors: Dyachenko V. D. , Tkachev R. P. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Developments in Stereoselective Palladium‐Catalyzed Allylic Alkylations of Preformed Enolates
Authors: Braun Manfred , Meier Thorsten 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pseudoproline Dipeptides in Fmoc Solid‐Phase Peptide Synthesis
Authors: Doerner Barbara , Steinauer Rene , Barthelemy Sophie , White Peter D. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Interconversion and tissue distribution of pentoxifylline and lisofylline in mice
Authors: Wyska Elżbieta , Pȩkala Elżbieta , Szymura‐Oleksiak Joanna 
Published: May 2006

AbstractThe aim of this study was to assess the interconversion pharmacokinetics and tissue distribution of pentoxifylline and the active (R)‐enantiomer of its metabolite M1, lisofylline in male CD‐1 mice. Both compounds were administered intravenously at a dose of 50 mg/kg on two separate occasions. Serum and tissues were collected at different time points following drug administration. In addition, the (S)‐enantiomer of M1 was administered to a group of mice and serum samples were obtained. Analyte concentrations were measured by chiral HPLC. All serum concentration versus time data were fitted simultaneously to a pharmacokinetic model incorporating interconversion processes of parent drug and metabolites. The estimated conversion clearance of (−)‐(R)‐M1 to pentoxifylline (CL21) was six times greater than that for the reverse process (CL12). The interconversion of pentoxifylline and (+)‐(S)‐M1 was faster as reflected by the values of conversion clearances CL13and CL31which were approximately 16 and 7 times greater in comparison with the corresponding clearances for the interconversion of pentoxifylline and (−)‐(R)‐M1. When fitting pharmacokinetic data of both parent compounds to a one‐compartment model, the values of elimination clearances assessed were close to those obtained on the basis of the interconversion model. After administration of pentoxifylline, tissue‐to‐serum AUC ratios ranged from 0.1 for liver and lungs to 0.32 for brain tissue. Serum levels of its metabolite, (−)‐(R)‐M1 were very low, whereas its tissue levels exceeded serum concentrations. The highest value of metabolite‐to‐parent AUC ratio (4.98) was observed in lungs. When (−)‐(R)‐M1 was given as a parent drug, tissue‐to‐serum AUC ratios in liver, kidney, and lungs were very close and ranged from 0.64 to 0.72. At the same time, levels of its metabolite, pentoxifylline were relatively low both in serum and all tissues studied. In consequence, metabolite‐to‐parent AUC ratios did not exceed the value of 0.27. In conclusion, reversible metabolism plays a modest role in the disposition of pentoxifylline and (−)‐(R)‐M1. It seems that pentoxifylline has less favourable pharmacokinetic properties than (−)‐(R)‐M1 due to lower concentrations attained in target organs. High levels of (−)‐(R)‐M1 observed after pentoxifylline administration in certain tissues such as liver or lungs suggest that pentoxifylline may constitute an effective prodrug for (−)‐(R)‐M1 in these organs. Chirality, 2006. © 2006 Wiley‐Liss, Inc.
Chiral Recognition of D‐Kyotorphin by Lipidic Membranes: Relevance Toward Improved Analgesic Efficiency
Authors: Lopes Sílvia C. D. N. , Fedorov Alexandre , Castanho Miguel A. R. B. 
Published: May 2006

AbstractD‐Kyotorphin (D‐KTP), the most potent isomer of the endorphin‐like dipeptide kyotorphin (KTP), is a good drug candidate for the treatment of chronic pain and is thought to be involved in receptor‐mediated processes. According to the “membrane catalysis” model, ligands interact with membrane lipids to attain high local concentrations in the receptor vicinity and to adopt the necessary conformation for docking. Therefore, the interaction and recognition of D‐KTP by membranes is potentially important to its increased analgesic effect. In spite of the neutral net charge of D‐KTP at pH 7.4, fluorescence spectroscopy reveals that the interaction with large unilamellar vesicles is more extensive than was observed for KTP. The tyrosine residue interacts extensively with rigid membranes, with a location and well‐defined orientation in the bilayer. This suggests not only that D‐KTP meets the structural constraints needed for receptor–ligand interaction in a manner similar to that of KTP, but also that the stronger membrane interaction and ability to discriminate rigid membrane domains might contribute to its improved analgesic effect.
High‐dose cytosine arabinoside in the treatment of acute myeloid leukemia
Authors: Kern Wolfgang , Estey Elihu H. 
Published: May 2006

AbstractBACKGROUNDThe use of high‐dose cytosine arabinoside (HDAraC) during induction may improve outcomes in patients with acute myeloid leukemia (AML) compared with standard‐dose AraC (SDAraC). The objective of this review was to assess the impact of HDAraC during induction therapy for patients with AML based on results from randomized trials.METHODSAll randomized trials in the field were identified by using a predefined search strategy. Trials that assessed the impact of HDAraC compared with SDAraC as induction therapy for adult patients with AML in a randomized fashion and that reported the relevant endpoints were included. Data were extracted from each trial by both reviewers according to prespecified criteria.RESULTSNo differences between HDAraC and SDAraC were found with regard to complete remission rates (relative risk, 1.00; 95% confidence interval [95% CI], 0.92‐1.10). The weighted mean difference (WMD) for median recurrence‐free survival (RFS) was 4.19 in favor of HDAraC (95% CI, 0.59‐7.78; P = .02). The WMD for 4‐year RFS was 10.98 in favor of HDAraC (95% CI, 1.02‐20.94; P = .03). The WMD for median overall survival (OS) was − 0.22 for HDAraC compared with SDAraC (95% CI, − 2.76‐2.32; P = .9). Data regarding the median OS was heterogeneous between studies (chi‐square P = .00), with 2 studies in favor of HDAraC and 2 studies in favor of SDAraC. The WMD for 4‐year OS was 6.21 in favor of HDAraC (95% CI, 2.70‐9.72; P = .0005).CONCLUSIONSInduction therapy with HDAraC improved long‐term disease control and overall survival in adults age < 60 years with de novo AML. It remains unknown whether patients should receive HDAraC during induction or if it is to be given during postremission therapy. Further analyses should focus on this issue and on the effects of HDAraC in prognostically different subgroups of patients with AML. Cancer 2006. © 2006 American Cancer Society.
The metabolic syndrome and risk of incident colorectal cancer
Authors: Ahmed Rehana L. , Schmitz Kathryn H. , Anderson Kristin E. , Rosamond Wayne D. , Folsom Aaron R. 
Published: May 2006

AbstractBACKGROUNDThe authors tested the hypothesis that the metabolic syndrome (≥3 of the following components: high blood pressure, increased waist circumference, hypertriglyceridemia, low levels of high‐density lipoprotein cholesterol, or diabetes/hyperglycemia) is a risk factor for colorectal cancer.METHODSData from the Atherosclerosis Risk in Communities (ARIC) multicenter prospective cohort study were used. Metabolic syndrome components and other risk factors were collected during 1987 to 1989 from the 14,109 men and women in these analyses. One hundred ninety‐four incident colorectal cancers were identified through the Year 2000. Multivariate Cox proportional hazards regression analyses were used to examine associations.RESULTSBaseline metabolic syndrome (≥3 components vs. 0 components) had a positive association with age‐adjusted and gender‐adjusted colorectal cancer incidence (relative risk [RR], 1.49; 95% confidence interval [95%CI], 1.0‐2.4); this association was attenuated after multivariate adjustment (RR, 1.39; 95%CI, 0.9‐2.2). There was a dose‐response association between colorectal cancer incidence and the number of metabolic syndrome components present at baseline (P for trend = .006) after multivariate adjustment. Analysis of gender revealed that the multivariate‐adjusted association of metabolic syndrome with colorectal cancer was stronger in men (RR, 1.78; 95%CI, 1.0‐3.6) and weaker in women (RR, 1.16; 95%CI, 0.6‐2.2).CONCLUSIONSIn this population‐based cohort, metabolic syndrome was a risk factor for incident colorectal cancer in men but not women. Evidence is growing that the metabolic syndrome may be a marker for a physiologic milieu of growth that encourages tumor initiation, promotion, and/or progression. Cancer 2006. © 2006 American Cancer Society.
Overexpression of jun activation domain‐binding protein 1 in nonsmall cell lung cancer and its significance in p27 expression and clinical features
Authors: Osoegawa Atsushi , Yoshino Ichiro , Kometani Takuro , Yamaguchi Masafumi , Kameyama Toshifumi , Yohena Tomofumi , Maehara Yoshihiko 
Published: May 2006

AbstractBACKGROUNDDecreased expression of p27, which is an inhibitor of cyclin‐dependent kinase, is associated with cancer aggressiveness. It is believed that Jun activation domain‐binding protein 1 (Jab1) plays a role in p27 degradation in a manner that is independent from the role played by S‐phase kinase‐associated protein 2 (Skp2). To examine the clinical significance of Jab1 in nonsmall cell lung cancer (NSCLC), the protein expression of Jab1 in tumor tissues was investigated with regard to the expression of p27 and Skp2.METHODSThe clinicopathologic features and immunohistochemical expression levels of Jab1, p27, and Skp2 proteins were studied in 138 specimens from patients who underwent surgical resection for NSCLC. Survival analyses were performed by using the Kaplan–Meier method and Cox regression models.RESULTSHigh Jab1 expression (>50% of cancer cell nuclei stained) was observed in 81 specimens (59%). In Skp2‐negative specimens (n = 81), an inverse correlation between the protein expression of p27 and Jab1 was observed both with the chi‐square test (P = .02) and with the Mann–Whitney U test (P = .02). High Jab1 expression levels were related to poor outcomes in 118 patients who underwent complete resection, with a 5‐year overall survival rate of 43.9% for patients who had high Jab1 expression and 63.1% for patients who had low Jab1 expression (P = .01). This difference was greater in patients who had Skp2‐negative specimens (51.9% vs. 79.3% (P = .02), but it was not significant in patients who had Skp2‐positive specimens. The multivariate analysis revealed that Jab1 expression was an independent prognostic factor for survival in patients with NSCLC (relative risk, 2.247; P = .01).CONCLUSIONSThe current results showed for the first time that high Jab1 protein expression is related to poor outcome in patients with NSCLC and that this protein may be a target of therapy in NSCLC. Cancer 2006. © 2006 American Cancer Society.
Ewing sarcoma‐family tumors that arise after treatment of primary childhood cancer
Authors: Spunt Sheri L. , Rodriguez‐Galindo Carlos , Fuller Christine E. , Harper JoAnn , Krasin Matthew J. , Billups Catherine A. , Khoury Joseph D. 
Published: May 2006

AbstractBACKGROUNDUnlike osteosarcoma, the Ewing sarcoma family of tumors (ESFT) has rarely been reported as secondary malignant neoplasms after treatment of childhood cancer. ESFT arising as a second cancer was reviewed and characterized at our childhood cancer center.METHODSA retrospective review was undertaken of 11,183 patients age <21 years who were treated for a primary cancer between March 1962 and December 2003 at St. Jude Children's Research Hospital. All cases of ESFT were confirmed to have a rearranged EWS gene.RESULTSSix cases of ESFT (1.3% of 479 second cancers) were identified in patients previously treated for lymphoma (n = 3), leukemia (n = 1), retinoblastoma (n = 1), or Wilms tumor (n = 1). None of these patients had a family history suggestive of a familial cancer syndrome. The median time between diagnosis of primary cancer and diagnosis of ESFT was 5.9 years (range, 3.1‐18.3 years). ESFT occurred in typical anatomic locations: rib (n = 2), chest wall soft tissues (n = 2), pelvis (n = 1), and extremity (n = 1). One tumor arose at the margin of a previous radiotherapy field and 1 arose distant from previous radiotherapy fields; all other patients had not received radiotherapy. Three patients are alive at the time of this report, including 2 whose ESFT was diagnosed more than 8 years ago.CONCLUSIONSESFT occurs rarely after treatment of a primary cancer during childhood, and most cases do not appear to be related to radiation therapy. Long‐term survival can be achieved in some patients, and therefore secondary ESFT should be treated with curative intent. Cancer 2006. © 2006 American Cancer Society.
Transdisciplinary studies of surgical oncology trial accrual
Authors: Albrecht Terrance L. , Kuerer Henry , Ruckdeschel John C. , Mendez Jane , Harper Felicity 
Published: May 2006

AbstractBACKGROUNDA key objective of the National Institutes of Health Roadmap Initiative during the past 2 years has been to address scientific problems and issues through innovative research collaborations that cut across disciplines, traditions, and agendas.METHODSRecognizing an opportunity to focus on the growing problem of low accrual to cancer surgical trials, the authors organized a multidisciplinary network of 21 clinical researchers and social/behavioral scientists to meet, review the issues, and organize working groups to study the problem. The authors, as representatives of the Karmanos Cancer Institute (Detroit, MI) and the American College of Surgeons Oncology Group, were awarded a Roadmap‐affiliated grant from the National Cancer Institute under the “Meetings and Networks for Methodological Development in Interdisciplinary Research” funding mechanism.RESULTSThe overarching objective that guided the methodological developments of this network was to apply state‐of‐the‐science methodologies and analytical strategies to examine the biobehavioral and interpersonal factors that facilitate or impede patients' treatment decision‐making.CONCLUSIONSIn this brief report, the authors describe the objectives of their multidisciplinary network and their progress to date. Cancer 2006. © 2006 American Cancer Society.