bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the Non-Parametric Signals Test to a Company
Authors: Sampaio Nilo Antônio S. , Mazza Felipe Cury , De Siqueira Sílvio Sérgio Silveira , Miranda Junior João Ercio , De Abreu Laura Dutra , De Lima Rafael Martins 
Published: February 2024

Objective: The aim of this paper is to show the application of the Non-Parametric Sign Test in problems involving the testing of central tendency values.

Theoretical framework: Non-parametric methods are widely used in the study of populations that are taken in rank order (such as a movie that receives one to four star ratings). The use of non-parametric methods may also be necessary when the data has a ranking but no clear numerical interpretation, such as when accessing preferences. In terms of scale, non-parametric methods result in data that is "in order" (Thatcher et al., 2005)

Method: Data was taken from a company in the South of Rio de Janeiro and a case study was carried out using the Non-Parametric Sign Test.

Final Considerations: Initially it proved unfeasible to use a Parametric Test because the Anderson-Darling Test showed that the Assumption of Normality was not confirmed and finally the Non-Parametric Sign Test showed that the hypothetical Median really is the correct measure of Central Tendency.

Implications of the research: The use of Non-Parametric Tests is widespread in scientific literature and has proven to be highly effective in dealing with data where the assumptions of Normality are not confirmed.

Originality/value: Despite being well-known statistical tools, Non-Parametric Tests are widely used and can bring innovations to their application, as in the case of the company in question.
Methods of regional analgesia in abdominal surgery in pediatrics
Authors: Barminskiy A. V. , Egorov A. N. , Kirov M. Yu. 
Published: February 2024

Introduction. Adequacy of perioperative analgesia is one of the main issues of surgical care. Anatomo-physiological and psychological characteristics of childhood necessitate more thorough approach to this problem in pediatric anesthesiology, since ensuring optimal analgesia provides prevention of somatic perioperative complications and influences further physiological neuropsychiatric development of a child.The objective was to compare regional techniques of perioperative analgesia during abdominal interventions in children and to discuss the conditionsof their application and effectiveness.Materials and Methods. A literature search was conducted using PubMed, Medline, Embase, and Google Scholar databases. Both English – and Russian-language publications indexed in Scopus and RSCI were included in the search.Results. Among methods of regional anesthesia, neuroaxial blockade options, which have both high proven efficacy and several disadvantages and complications, remain the most popular techniques. Currently, the alternative methods are available, presented as interfascial blockades with anefficacy comparable to neuroaxial techniques and a wide safety profile. Among these techniques, we can distinguish rectus sheath block, transversus abdominis plane block, erector spinae plane block and other methods.Conclusion. Despite advances in pain management, inadequate postoperative analgesia in pediatric practice remains a serious problem. Therefore, it is important to optimize the treatment of postoperative pain in children by applying multimodal analgesia using modern regional blockades.
Hematological, biochemical, coagulation profiles of patients with cerebral palsy and epilepsy on the background of taking valproic acid in the perioperative period
Authors: Evreinov V. V. 
Published: February 2024

Introduction. Valproic acid is one of the commonly prescribed basic anticonvulsants for the treatment of epileptic seizures in children with cerebral palsy. Its active metabolites can cause hematological and coagulation disorders, cause valproate-induced steatohepatitis.The objective was to assess the level of hematological, biochemical and coagulation blood parameters in the perioperative period in children with severe forms of cerebral palsy during the treatment of concomitant epilepsy with valproic acid.Materials and methods. A prospective cohort study included 72 patients with cerebral palsy, spastic hip dislocations, who underwent reconstructive interventions on hip joints. Depending on the presence of concomitant epilepsy, the patients were divided into two groups. Perioperative laboratory blood parameters, complication incidence, the duration of stay in the intensive care unit and hospitalization were assessed.Results. In patients with epilepsy, the number of platelets in the blood was lower compared to the control group. The level of alkaline phosphatase before and after surgery in 34 % of children who took anticonvulsants exceeded the maximum value of the norm. Groups differed in terms of peri -operative coagulogram and thromboelastography. The frequency of complications in patients with epilepsy ranged from 0.08 % to 16.2 %.Conclusions. Basic therapy with valproic acid in children with severe forms of cerebral palsy and concomitant epilepsy is associated with a tendency to hypocoagulation, but was not accompanied by clinically significant thrombocytopenia or coagulopathy during hip surgery. Taking valproic acid drugs in patients with cerebral palsy and epilepsy was not accompanied by an increase in serum liver enzymes at all stages of observation, which minimized the likelihood of valproate-induced hepatotoxicity. Anticonvulsant therapy with valproate in children with severe forms of cerebral palsy and concomitant epilepsy did not increase the potential risk of complications in the perioperative period, did not affect the duration of stay of patients in the intensive care unit and hospitalization.
A pilot study of the clinical significance and outcomes of infections in the ICU caused by colistin-resistant Klebsiella pneumoniae
Authors: Sychev I. N. , Ignatenko O. V. , Yakovlev S. V. , Fedina L. V. , Burmistrova E. N. , Suvorova M. P. , Rastvorova T. D. , Strigunkova E. V. , Mukhamadiev R. Kh. 
Published: February 2024

The objective was to study the risk factors, outcomes of infections caused by colistin-resistant K. pneumonia (CRKP) and to evaluate the sensitivity of these microorganisms to antibacterial agents to determine the most adequate antibiotic therapy options.Materials and methods. Klebsiella pneumoniae strains isolated in the ICU of an acute care hospital between October 2020 and August 2022 were included in the study. Microorganisms were identified using an automatic analyzer PHOENIX. The determination of antibiotic sensitivity was studied by the method of serial micro-dilutions in agar with the determination of MIC EUCAST criteria were used to interpret sensitivity. Detection of carbapenemases was carried out by PCR. Clinical efficacy of starter therapy was evaluated as recovery/improvement and no effect.Results. The infection was characterized by a severe course in 58.9 % of patients, with SOFA scores ranging from 1 to 16 points (mean 5.8 points). 88.2 % of patients had received prior antibiotics, most commonly carbapenems. CRKP infections occurred more frequently in older men with comorbidity. The clinical efficacy of initial antibiotic therapy was 41.2 %. In 47.1 % of cases, there was no effect, which required adjustment of therapy. Excluding patients in whom it was impossible to evaluate the effect, eradication was achieved in 33.3 % of patients. 64.6 % of patients were discharged or transferred to another hospital; 6 patients died between 5 and 41 days after diagnosis of CRKP infection. Fatal outcome was more frequent in women ( p=0.042), patients with higher comorbidity index (p=0.027), in case of sepsis and/or septic shock ( p=0.011), and in earlier detection of CRKP after hospitalization ( p<0.001).Conclusion. The efficacy of initial antibiotic therapy after detection of CRKP infection has been shown to be associated with patient survival and reduced risk of mortality with an odds ratio of 3.5. We also identified risk factors for mortality in CRKP infection: comorbidity, sepsis, duration of hospitalization and female gender.
Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study
Authors: Masolitin S. V. , Protsenko D. N. , Tyurin I. N. , Shifman E. M. , Magomedov M. A. , Gelfand E. B. , Lomidze S. V. , Bykov A. O. , Grishina L. A. , Kolerova I. V. , Losev D. V. , Shukurova K. F. , Kashentseva N. A. , Gagieva N. A. 
Published: February 2024

Introduction . The choice of the method and time of initiation of extracorporeal detoxification (ECD) in septic shock (SSh) complicated by acute kidney injury (AKI) is a debatable problem.The objective was to evaluate the influence of various ECD tactics on the dynamics of markers of systemic endotoxicosis and acid-base status (ABS) in patients with SSh complicated by AKI.Materials and methods. Study included 57 patients. Group 1 – 36 patients used continuous veno-venous hemodiafiltration (CVVHDF) for urgent indications. Group 2 – 21 patients used early combined ECD (LPS-sorption and CVVHDF). A comparative analysis of the main laboratory parameters between the groups was performed.Results. Early combined ECD made it possible to reduce the concentration of leukocytes by the 3rd day of therapy from 20.6 to 12.5 ·109/l (39.3 %) from the initial level in group 2, and from 22.2 to 19.15·109/l (13.7 %) in group 1 ( p=0.04); C-reactive protein by the 5th day of therapy from 284 to 145 mg/l (48.9 %) in group 2, and from 299.3 to 199.8 mg/l (33.2 %) in group 1 ( p=0.02); procalcitonin by the 5th day of therapy from 7.2 to 1.6 ng/ml (77.8 %) in group 2, and from 7.8 to 4.45 ng/ml (42.9 %) in group 1 ( p= 0.02); pH by the 3rd day of therapy from 7.17 to 7.37 in group 2, and from 7.19 to 7.27 in group 1 (p =0.04); IL-6 level by the 5th day of therapy from 764.9 to 361.7 pg/ml (52.7 %) in group 2, and from 700.1 to 542.5 pg/ml (22.5 %) in group 1 (p=0.007).Conclusions. Early combined ECD more quickly reduces markers of systemic endotoxicosis and eliminates impairment of ABS, than CVVHDF.
The effect of renal replacement therapy on the concentration of tigecycline in the blood in patients with sepsis-associated acute kidney injury
Authors: Marukhov A. V. , Zakharov M. V. , Murzina E. V. , Buryakova L. V. , Sofronov G. А. , Zhurkovich I. K. , Ostrovidova E. V. , Lazarenko D. U. , Kriylova T. G. 
Published: February 2024

The objective was to evaluate the effect of renal replacement therapy on the concentration of tigecycline in the blood in the treatment of patients with sepsis and acute kidney injury.Materials and methods. The serum level of tigecycline was analyzed in three patients with sepsis-associated acute kidney injury against the back -ground of renal replacement therapy (RRT) in the hemodiafiltration mode. The quantitative content of tigecycline was determined by high-performance liquid chromatography.Results. Significant variability of serum tigecycline levels was revealed in patients with sepsis-associated acute kidney injury (AKI) under the conditions of the use of RRT. The use of standard dosage regimens of tigecycline in this situation may be accompanied by both a significant increase in the concentration of the drug in the blood relative to the target values, and its low level, which does not reach the values of the minimum inhibitory concentration (MIC) for pathogenic strains.Conclusion. Significant variability of serum concentrations of tigecycline in patients with sepsis-associated AKI against the background of RRT causes the emergence of potential risks associated with both insufficient safety of treatment due to possible accumulation and significant excess of the target concentration value against the background of inhibition of the functions of the physiological excretory systems of the body, so with the low effectiveness of antibacterial therapy in conditions of increasing the rate of elimination of the drug from the systemic bloodstream due to extracorporeal clearance and reducing the concentration of the antibiotic to subtherapeutic.
The effectiveness of succinate cardioprotection during vascular surgery in high cardiac risk patients
Authors: Kozlov I. A. , Sokolov D. A. , Lyuboshevsky P. A. 
Published: February 2024

The objective was to study the occurrence of perioperative cardiovascular complications (CVС) and clinical and laboratory cardioprotection parameters in patients treated with an infusion of a succinate-containing drug during the intraoperative period of vascular surgery.Materials and methods. The study involved 120 patients with high cardiac risk (revised cardiac risk index > 2, risk of perioperative myocardial infarction or cardiac arrest > 1 %) who underwent elective vascular surgery. Patients were randomly divided into two groups. Patients of group 1 received intraoperative infusion of succinate-containing drug at a dose of succinate 0.35 [0.26–0.40] mg/kg/min– 1. Group II was a control group. In the perioperative period, the occurrence of perioperative CVC, the blood level of the N-terminal segment of natriuretic B-type prohormone (NT-proBNP) and cardiospecific troponin I (cTnI) were analyzed.Results. Perioperative CVC was registered in 11 (18.3 %) patients of group I and in 11 (18.3 %) patients of group II (p = 1.0). The level of NT-proBNP in patients of group I and group II was 207 [160–300] pg/ml and 229 [150.6–298.9] pg/ml (p = 0.817) before surgery, 234.2 [155.9–356] and 277 [177.7–404] pg/ml ( p = 0.207) after surgery and 240.5[149.3–306] and 235.5 [133–495.1] pg/ml ( p = 0.979) before discharge from the hospital. An increased level of cTnI after surgery was recorded in 4 (6.7 %) patients of group I and in 1 (1.7 %) patient ( p = 0.364) of group II.Conclusion. Intraoperative infusion of succinate-containing drug does not affect the occurrence of CVC in patients with high cardiac risk during vascular surgery. The succinate-containing drug does not affect the preoperative level of NT-proBNP and cTnI.
Online Sequence-Based Deep Learning Approach for Metallic Debossed and Embossed Turbomachinery Blade Text Recognition Application
Authors: Youssef A. , Mishra P. , Vitale M. , Schillaci G. , Veneri G. , Bettini A. , Anatriello G. , Burbui M. , Ceccherini F. 
Published: February 2024

Abstract
Extracting the engraved characters of metal parts in the industrial sphere remains a challenging task due to low visual contrast, uneven illumination, corroded surfaces, and cluttered backgrounds of metal part images. Affected by these factors, generally existing methods could not identify low-contrast text areas very well. Furthermore, the task is complicated by the fact that the embossed and deposed text can have a wide range of appearances, including variations in curvature, orientation, and distortion, which makes it more difficult to accurately recognize the text. In this paper, we investigate a sequence-based approach consisting of detection and recognition deep learning models for blade text recognition. These models are integrated into a feedforward pipeline that segments, detects, and recognizes embossed and debossed imprinted text on metal surfaces. The text localization model utilizes a U-shaped network with a VGG-16 architecture for feature extraction. On the other hand, the text recognition model is an end-to-end convolutional neural network designed for image-based text recognition, capable of handling arbitrary sequence lengths and orientations.
Modeling the Effect of Transient Viscous Forces on Sucker Rod Pump Performance and Run Lift
Authors: Aql A. A. , Al-Safran E. M. 
Published: February 2024

Abstract
The sucker rod pump is commonly used to lift heavy oil wells under thermal production to maximize the flow rate due to its high efficiency and reliability. However, rod fatigue and possible failure are commonly encountered when rod design does not incorporate the appropriate loads, especially in high-viscosity conditions. Although the existing commercial design tools solve the wave equation to predict rod string life, they do not incorporate the effect of liquid viscosity, resulting in prediction discrepancy and inappropriate rod design and pump operation. The aim of this study is to propose a theoretical model to investigate the effect of the transient frictional forces acting on sucker rod pump subsurface components, i.e. rod and pump. Furthermore, a sensitivity analysis case study is carried out to investigate the effect of various flow and design parameters on the rod top-of-section stresses, rod buckling tendency, and fatigue life. This work provides a comprehensive understanding of the underlying interaction between fluid flow behavior and rod dynamics.
Cased-Hole Saturation Tool is Crucial for Optimizing Production and Reducing Uncertainties in a Naturally Fracture Carbonated Reservoir, Offshore, Libya
Authors: Grada Abdurahman , Ahmed Hamza , Elgihani Anis , Almalti Abduallah , Imhimmid Abdulrraziq , Mansour Kareema , Mohamed Nureddin , Mohamed Mnani 
Published: February 2024

Abstract
Bouri Field is an offshore saturated oil-bearing structure. The reservoir is a fractured carbonated deposit, and during production, gas and water are moving into the oil zone at the top and bottom, respectively. Consequently, monitoring the contacts is essential to optimizing field production. Unfortunately, the Gas-Oil contact (GOC) remains an uncertain parameter which directly impacts the selection of the targeted zone. Since the gas is flared out and limited gas capacity is allowed in the surface facilities, therefore, reducing gas production is essential. In addition to gas production issue, many wells stopped producing because of high water cut. At the early stages of the production history, the reservoir pressure was high enough to enhance lifting the fluid naturally all the way to the surface. However, some wells struggle to flow naturally when the reservoir pressure gradually decreases. Even though, there are many reasons behind the high-water production, nevertheless, understanding the Oil-Water contact (OWC) will be extremely valuable in managing the undesired water. This paper presents work has been done to evaluate the current field contacts by performing cased hole saturation logging tool to optimize production and reactivate shut-in wells to a number of 17 wells in Bouri field.
Well by well analysis was carried out to assess the field potential. The thorough evaluation included reviewing the wells events and operations, production and pressure history, fracture signatures, water production analysis. Considering set of criteria, a systematic approach was followed to select the key wells to be used for the saturation logging campaign to identify the regional contacts. These contacts will be an essential input to the workover program to mitigate the damage and control the unwanted water.
As a result of the study, five wells were chosen for the saturation logging campaign. The campaign revealed a dramatic change in the contact. In some areas, the OWC has raised and covered considerable interval of the reservoir thickness. While in other areas, the gas has expanded and found its way to the perforation. By correlating the saturation profiles form the key wells, the oil zone was identified along the field and a perforation, water shut-off and stimulation campaigns were proposed accordingly. A acritical water cut was which above the wells cannot produce naturally was detected around 60% to 80% depends on the wells’ locations. Three wells considered for Electrical Submersible Pumps (ESP) to extend the wells life and maintain the production.
It was recommended to perform borehole images to understand the fracture locations and density to be considered for any fracture network analysis. Building an accurate simulation model is another reason to update the saturation profile of such complex field.
Advanced Production Diagnostics and Optimized Drilling Strategy: Unlocking the True Potential of Production Data Using Physics and Machine Learning
Authors: Haider S. 
Published: February 2024

Abstract
Reliable well survival statistics forecast for shale wells is crucial for investment decisions, optimized drilling rates, and energy security policies. At present, the industry lacks a standard analytical or data-driven solution for survival probability estimation in both space and time. We present a state-of-the-art physics-guided and data-driven model for well survival statistics forecast with an error of less than 5%. The implications include optimized long-term drilling strategy, robust well production diagnostics, and profitable economic decisions.
Post pressure interference time, τ, the production rate of an unconventional well declines exponentially. Early and accurate estimation of τ is of utmost importance. Using 5000 wells (from Barnett, Marcellus, Haynesville, and Eagle Ford) as the training sample, we developed a universal neural network model to estimate the pressure interference time, τ, of a well. The estimated τ is coupled with the physics-based physical scaling curve to estimate the well survival statistics with time. Finally, the well survival statistics is used to calculate the residual production rate and its consequences on future well fracking strategy.
The robustness of the neural network model (ANN) is tested on a test set comprising 6000 wells from Barnett, Haynesville, Eagle Ford, and Marcellus. Using initial well production data, and a single ANN model the predicted pressure interference time τ, has an R2 of 0.98. The well survival statistics estimates for the next 10 years in the future achieved an accuracy of 95%, 93%, 96%, and 95% for Barnett, Marcellus, Haynesville, and Eagle Ford respectively. We found that with time τ has decreased for all the plays (Barnett, Haynesville, Eagle Ford and Marcellus). The estimated well survival statistics is shown to have a strong effect on the optimized and profitable drilling strategy.
We have used production data and a physics-informed neural network to unlock future production diagnostics with high certainty. The new and robust state-of-the- art hybrid model estimates the future pressure interference time of wells with an accuracy of 98%. The model calculates the future well survival statistics with time with an average accuracy of 95%. Early and accurate estimation of future production diagnostics governed future investment decisions, re-fracking strategy, and improved energy security strategy.