bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental and behavioral phenotypes of pediatric patients with PTEN hamartoma tumor syndrome
Authors: MacFarland Suzanne P. , Duvall Melani , Kemajou Raissa Tchetcho , Baldino Sarah E. , Zelley Kristin , Black Chelsea , Thomas Allison , Thomas Nina H. , Ruffner Melanie , Li Yimei , Miller Judith S. , Brodeur Garrett M. , Shabason Emily 
Published: March 2024

AbstractOur study characterized the neurodevelopmental spectrum of individuals with PTEN Hamartoma Tumor Syndrome (PHTS), a syndrome that predisposes to both neurodevelopmental phenotypes and cancer risk. We aim to better understand life‐impacting neurodevelopmental features of PHTS. Our study recruited 20 children/adolescents with PHTS, who were then administered assessments for autism spectrum disorder (ASD) and other neurocognitive measures, including assessment of IQ, executive and adaptive functioning, and health‐related quality of life. Thirteen individuals (65%) were identified as having ASD, of which five were newly diagnosed during the study. Of those, ASD symptom severity was in the mild–moderate range for 77%. Overall, IQ was in the average range, with a mean of 92.61 (SD 24.45, p = 0.5), though there was a non‐statistically significant trend toward individuals without ASD having a higher mean IQ (102.7 vs 82.3; p = 0.1). Subjects had significant impairment in processing speed (mean 75.38, SD 24.75, p < 0.05), decreased adaptive functioning skills across all domains, and a trend toward having more executive functioning problems. Individuals with PHTS are at increased risk of neurodevelopmental disorders, including ASD and impaired executive and adaptive functioning. Although clear guidelines exist for cancer surveillance for individuals with PHTS, additional guidelines and screening for neurodevelopmental disorders are warranted.
Longitudinal normative standards for cognitive tests and composites using harmonized data from two Wisconsin AD‐risk‐enriched cohorts
Authors: Jonaitis Erin M. , Hermann Bruce P. , Mueller Kimberly D. , Clark Lindsay R. , Du Lianlian , Betthauser Tobey J. , Cody Karly , Gleason Carey E. , Christian Bradley T. , Asthana Sanjay , Chappell Richard J. , Chin Nathaniel A. , Johnson Sterling C. , Langhough Rebecca E. 
Published: March 2024

AbstractINTRODUCTIONPublished norms are typically cross‐sectional and often are not sensitive to preclinical cognitive changes due to dementia. We developed and validated demographically adjusted cross‐sectional and longitudinal normative standards using harmonized outcomes from two Alzheimer's disease (AD) risk‐enriched cohorts.METHODSData from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were combined. Quantile regression was used to develop unconditional (cross‐sectional) and conditional (longitudinal) normative standards for 18 outcomes using data from cognitively unimpaired participants (N = 1390; mean follow‐up = 9.25 years). Validity analyses (N = 2456) examined relationships between percentile scores (centiles), consensus‐based cognitive statuses, and AD biomarker levels.RESULTSUnconditional and conditional centiles were lower in those with consensus‐based impairment or biomarker positivity. Similarly, quantitative biomarker levels were higher in those whose centiles suggested decline.DISCUSSIONThis study presents normative standards for cognitive measures sensitive to pre‐clinical changes. Future directions will investigate potential clinical applications of longitudinal normative standards.Highlights
Quantile regression was used to construct longitudinal norms for cognitive tests.
Poorer percentile scores were related to concurrent diagnosis and Alzheimer's disease biomarkers.
A ShinyApp was built to display test scores and norms and flag low performance.
Hydrogels with Differentiated Hydrogen‐Bonding Networks for Bioinspired Stress Response
Authors: Zhao Wei , Wu Baohu , Lei Zhouyue , Wu Peiyi 
Published: March 2024

AbstractStress response, an intricate and autonomously coordinated reaction in living organisms, holds a reversible, multi‐path, and multi‐state nature. However, existing stimuli‐responsive materials often exhibit single‐step and monotonous reactions due to the limited integration of structural components. Inspired by the cooperative interplay of extensor and flexor cells within Mimosa's pulvini, we present a hydrogel with differentiated hydrogen‐bonding (H‐bonding) networks designed to enable the biological stress response. Weak H‐bonding domains resemble flexor cells, confined within a hydrophobic network stabilized by strong H‐bonding clusters (acting like extensor cells). Under external force, strong H‐bonding clusters are disrupted, facilitating water diffusion from the bottom layer and enabling transient expansion pressure gradient along the thickness direction. Subsequently, water diffuses upward, gradually equalizing the pressure, while weak H‐bonding domains undergo cooperative elastic deformation. Consequently, the hydrogel autonomously undergoes a sequence of reversible and pluralistic motion responses, similar to Mimosa's touch‐triggered stress response. Intriguingly, it exhibits stress‐dependent color shifts under polarized light, highlighting its potential for applications in time‐sensitive “double‐lock” information encryption systems. This work achieves the coordinated stress response inspired by natural tissues using a simple hydrogel, paving the way for substantial advancements in the development of intelligent soft robots.
Achieving Strong Circularly Polarized Luminescence through Cascade Cationic Insertion in Lead‐free Hybrid Metal Halides
Authors: Song Tao , Wang Cheng‐Qiang , Lu Haolin , Mu Xi‐Jiao , Wang Bo‐Long , Liu Ji‐Zhong , Ma Bo , Cao Jing , Sheng Chuan‐Xiang , Long Guankui , Wang Qiang , Zhang Hao‐Li 
Published: March 2024

AbstractGenerating circularly polarized luminescence (CPL) with simultaneous high photoluminescence quantum yield (PLQY) and dissymmetry factor (glum) is difficult due to usually unmatched electric transition dipole moment (μ) and magnetic transition dipole moment (m) of materials. Herein we tackle this issue by playing a “cascade cationic insertion” trick to achieve strong CPL (with PLQY of ~100 %) in lead‐free metal halides with high glum values reaching −2.3×10−2 without using any chiral inducers. Achiral solvents of hydrochloric acid (HCl) and N, N‐dimethylformamide (DMF) infiltrate the crystal lattice via asymmetric hydrogen bonding, distorting the perovskite structure to induce the “intrinsic” chirality. Surprisingly, additional insertion of Cs+ cation to substitute partial (CH3)2NH2+ transforms the chiral space group to achiral but the crystal maintains chiroptical activity. Further doping of Sb3+ stimulates strong photoluminescence as a result of self‐trapped excitons (STEs) formation without disturbing the crystal framework. The chiral perovskites of indium‐antimony chlorides embedded on LEDs chips demonstrate promising potential as CPL emitters. Our work presents rare cases of chiroptical activity of highly luminescent perovskites from only achiral building blocks via spontaneous resolution as a result of symmetry breaking.
Interface‐Targeting Carrier‐Catalytic Integrated Design Contributing to Lithium Dihalide‐Rich SEI toward High Interface Stability for Long‐Life Solid‐State Lithium‐Metal Batteries
Authors: Zhou Xuanyi , Huang Fenfen , Zhang Xuedong , Zhang Biao , Cui Yingjie , Wang Zehua , Yang Qiong , Ma Zengsheng , Liu Jun 
Published: March 2024

AbstractThe generation of solid electrolyte interphase (SEI) largely determines the comprehensive performance of all‐solid‐state batteries. Herein, a novel “carrier‐catalytic” integrated design is strategically exploited to in situ construct a stable LiF‐LiBr rich SEI by improving the electron transfer kinetics to accelerate the bond‐breaking dynamics. Specifically, the high electron transport capacity of Br‐TPOM skeleton increases the polarity of C−Br, thus promoting the generation of LiBr. Then, the enhancement of electron transfer kinetics further promotes the fracture of C−F from TFSI− to form LiF. Finally, the stable and homogeneous artificial‐SEI with enriched lithium dihalide is constructed through the in situ co‐growth mechanism of LiF and LiBr, which facilitatse the Li‐ion transport kinetics and regulates the lithium deposition behavior. Impressively, the PEO‐Br‐TPOM paired with LiFePO4 delivers ultra‐long cycling stability over 1000 cycles with 81 % capacity retention at 1 C while the pouch cells possess 88 % superior capacity retention after 550 cycles with initial discharge capacity of 145 mAh g−1at 0.2 C in the absence of external pressure. Even under stringent conditions, the practical pouch cells possess the practical capacity with stable electric quantities plateau in 30 cycles demonstrates its application potential in energy storage field.
Mercury‐Group 13 Metal Covalent Bonds: A Systematic Comparison of Aluminyl, Gallyl and Indyl Metallo‐ligands
Authors: Griffin Liam P. , Ellwanger Mathias A. , Crumpton Agamemnon E. , Roy Matthew M. D. , Heilmann Andreas , Aldridge Simon 
Published: March 2024

AbstractBimetallic compounds containing direct metal‐group 13 element bonds have been shown to display unprecedented patterns of cooperative reactivity towards small molecules, which can be influenced by the identity of the group 13 element. In this context, we present here a systematic appraisal of group 13 metallo‐ligands of the type [(NON)E]− (NON=4,5‐bis(2,6‐diisopropylanilido)‐2,7‐di‐tert‐butyl‐9,9‐dimethylxanthene) for E=Al, Ga and In, through a comparison of structural and spectroscopic parameters associated with the trans L or X ligands in linear d10 complexes of the types LM{E(NON)} and XM′{E(NON)}. These studies are facilitated by convenient syntheses (from the In(I) precursor, InCp) of the potassium indyl species [{K(NON)In}⋅KCp]n (1) and [(18‐crown‐6)2K2Cp] [(NON)In] (1′), and lead to the first structural characterisation of Ag−In and Hg−E (E=Al, In) covalent bonds. The resulting structural, spectroscopic and quantum chemical probes of Ag/Hg complexes are consistent with markedly stronger σ‐donor capabilities of the aluminyl ligand, [(NON)Al]−, over its gallium and indium counterparts.
Design and hydraulic study of double‐partition dividing‐wall column
Authors: Guan Shengyi , Li Yongshuai , Li Gaoyang , Zhu Litao , Pan Hui , Ling Hao 
Published: March 2024

AbstractDividing‐wall column (DWC) provides tremendous advantages in terms of energy savings and capital costs for three‐component and even multi‐component separations. With increasing industrial application of three‐component DWCs, DWCs for separation of four‐component have received considerable research attention. The aim of this work is to investigate the design of the two‐staggered wall region and gas–liquid two‐phase flow behavior on the tray in a double‐partition DWC (DPDWC). The Aspen Plus was applied to simulate the steady state to obtain the gas–liquid‐phase flow rate in each region to serve as the basis for the tray design. In different task regions, the gas‐ and liquid‐phase flow varied in some ways. The drag models have variability for the study of fluid flow, and the Tomiyama model is more appropriate. Moreover, high‐velocity gradients and recirculating phenomenon can be discovered owing to the existence of multiple partitions in DPDWC.
Influence of N,N′‐ethylene bis oleamide on the flowability of the acrylonitrile‐butadiene‐styrene resin and lubrication mechanism
Authors: Sun Xiang , Lu Shulai , Song Zhenbiao , Kang Ning , Zhao Shicheng 
Published: March 2024

AbstractAs a high‐performance engineering plastic, the acrylonitrile‐butadiene‐styrene (ABS) resin possesses excellent heat resistance, chemical resistance, and toughness. However, there is a lack of flow properties of the ABS resin for many processing operations. With the aim of enhancing the flowability of the ABS resin, the effect of N,N′‐ethylene bis oleamide (EBO) as a new lubricant on the melt flow rate (MFR), torque value, and rheological behavior of the ABS resin was investigated. The result showed the MFR of the ABS resin with 2.0 wt% EBO was 22.1 g/10 min, which was improved by 49% compared with the pure ABS resin (14.8 g/10 min). The torque value of the ABS resin, including 2.0 wt% EBO (1.69 N m) was lower than that of the pure ABS resin (2.03 N m). The rheological study further indicated that EBO can reduce the complex viscosity of the ABS resin. The above results indicated that EBO was an effective lubricant for the ABS resin. A possible lubrication mechanism was proposed based on the consequences of the rotational rheometry, dynamic mechanical analysis, and molecular dynamics simulation. EBO decreased the entanglement density of the polystyrene‐acrylonitrile (SAN) molecular chains and increased the mobility of the SAN molecular chain segments. On the other hand, EBO increased the free space of motion of the SAN molecular chain segments due to the free‐volume effect thereby increasing the mean square displacement of the system. This work will provide a new way to achieve the high‐flow ABS resin and provide new insights into the lubrication mechanism of lubricants in the ABS resin thereby expanding the applications of the ABS resin.
A comparative study on grasping‐related muscles in five Accipitriformes species
Authors: Wang Lin , Liu Xiyuan , Zhang Zihui 
Published: March 2024

AbstractAccipitriformes are diverse in their prey preferences and use their grasping feet for hunting. Little is known about the architectural design of muscles related to grasping among species of different sizes, diets, and foraging behaviors. In the present study, we report quantitative data and analysis of the pelvic musculature of the Japanese sparrowhawk (Accipiter gularis), Eurasian sparrowhawk (Accipiter nisus), common buzzard (Buteo buteo), northern goshawk (Accipiter gentilis), and cinereous vulture (Aegypius monachus). As expected, mass and architecture of the considered muscles were very different between the cinereous vulture and the four other species. The cinereous vulture allocates more mass and physiological cross‐sectional area (PCSA) to the proximally inserted flexor muscles, which indicates the rudimentary grasping ability of the foot and is a myological reflection of its carrion preference. Furthermore, in the cinereous vulture, muscles were built with the lowest architectural index (AI) compared with the other species, and the intrinsic foot muscles were short‐fibered, which is disadvantageous for rapid manipulation and foot dexterity. The other four species, as a whole, featured large flexor hallucis longus (FHL) muscles and better development of distally inserted flexors, reflecting their predatory lifestyle. Some differences were also found between the species that consumed birds and those that consumed mammals. The two avivorous species were superior in AI and fiber length of the intrinsic foot muscles which are suitable for good hunting speed and digit flexibility, the prerequisition for hunting agile prey.
MXene/Silk Fibroin Strengthened PVA–Based Eutectogel with Excellent Self–Healing Ability and Environmental Adaptability: Design, Synthesis, and Sensing Application
Authors: Zhai Hanlin , Yue Chen , Li Zhangpeng , Ma Limin , Wang Tingting , Zhang Hong , Wang Jinqing , Yang Shengrong 
Published: March 2024

AbstractA superelastic self–healing eutectogel was designed and prepared using poly (vinyl alcohol) (PVA) as the bulk skeleton material, while silk fibroin (SF) and two–dimensional (2D) MXene (Ti3C2TX) as reinforcing fillers. In brief, the eutectogel possesses a high tensile strength of 7.63 MPa, and its elongation at break reached 1115.2%, higher than most reported polymers (<1000%). In addition, the eutectogel–assembled sensor has a high ionic conductivity of 0.61 S/m and a high strain sensitivity of 5.17 kPa−1. Moreover, eutectogel shows excellent self–healing ability and can achieve self–healing quickly within 10 min, while its tensile strength and elongation at break can be restored to 84.7% and 97.4% of the initial levels. Besides, a stable electrical signal can be transmitted after 200 cycles at 30% strain. Finally, the eutectogel can withstand various environmental conditions, such as atmospheric or even vacuum evaporation and low–temperature freezing, while maintaining good mechanical and sensing performances. The assembled flexible sensors based on the eutectogel demonstrate their significant application prospects in wearable devices, especially human physiological monitoring.
Development of Anisotropic Electrically Conductive GNP‐Reinforced PCL‐Collagen Scaffold for Enhanced Neurogenic Differentiation under Electrical Stimulation
Authors: Ghosh Souvik , Roy Partha , Lahiri Debrupa 
Published: March 2024

AbstractThe internal electric field of the human body plays a crucial role in regulating various biological processes, such as, cellular interactions, embryonic development and the healing process. Electrical stimulation (ES) modulates cytoskeleton and calcium ion activities to restore nervous system functioning. When exposed to electrical fields, stem cells respond similarly to neurons, muscle cells, blood vessel linings, and connective tissue (fibroblasts), depending on their environment. This study develops cost‐effective electroconductive scaffolds for regenerative therapy. This was achieved by incorporating carboxy functionalized graphene nanoplatelets (GNPs) into a Polycaprolactone (PCL)‐collagen matrix. ES was used to assess the scaffolds′ propensity to boost neuronal differentiation from MSCs. This study reported that aligned GNP‐reinforced PCL‐Collagen scaffolds demonstrate substantial MSC differentiation with ES. This work effectively develops scaffolds using a simple, cost‐effective synthesis approach. The direct coupling approach generated a homogeneous electric field to stimulate cells cultured on GNP‐reinforced scaffolds. The scaffolds exhibited improved mechanical and electrical characteristics, as a result of the reinforcement with carbon nanofillers. In vitro results suggest that electrical stimulation helps differentiation of mesenchymal stem‐like cells (MSC‐like) towards neuronal. This finding holds great potential for the development of effective treatments for tissue injuries related to the nervous system.
Biocompatible Gold Nanoparticles‐Modified Fluorine Doped Tin Oxide Electrode for the Fabrication of Enzyme‐Free Glucose Sensor
Authors: Abu Nayem S. M. , Islam Santa , Shah Syed Shaheen , Awal Abdul , Ghann William , Anand Deepak , Ahmad Irshad , Uddin Jamal , Aziz Md. Abdul , Saleh Ahammad A. J. 
Published: March 2024

AbstractThis work demonstrates the use of jute stick extract as a reducing and stabilizing agent for the synthesis of spherical gold nanoparticles (AuNPs). In UV‐Vis spectroscopy, peak at 550 nm was used to confirm the formation of AuNPs. The spherical surface morphology of AuNPs was determined through SEM and TEM analysis. While XRD investigation revealed the crystallinity of the prepared AuNPs. To ensure the biocompatibility of synthesized AuNPs, a bacterial investigation was conducted with negative results towards bacterial strain. The, modified FTO with AuNPs were able to detect glucose in CV analysis and the constructed sensor displayed a wide linear range of 50 μM to 40 mM with a detection limit of 20 μM. Scan rate analysis was performed to determine the charge transfer coefficient (0.42) and Tafel slope (102 mV/decade). Furthermore, the interfacial surface mechanism is illustrated to understand the interaction of glucose with the electrode surface in an alkaline medium and the product formation through the dehydrogenation and hydrolysis process. The prepared sensor also showed good stability, reproducibility, and anti‐interference capabilities. In the case of real sample analysis, we used a blood serum sample. A low RSD value (<10 %) suggests the practical use of AuNPs/FTO in real‐life applications.
Construction and validation of artificial intelligence pathomics models for predicting pathological staging in colorectal cancer: Using multimodal data and clinical variables
Authors: Tan Yang , Liu Run , Xue Jia‐wen , Feng Zhenbo 
Published: March 2024

AbstractObjectiveThis retrospective observational study aims to develop and validate artificial intelligence (AI) pathomics models based on pathological Hematoxylin–Eosin (HE) slides and pathological immunohistochemistry (Ki67) slides for predicting the pathological staging of colorectal cancer. The goal is to enable AI‐assisted accurate pathological staging, supporting healthcare professionals in making efficient and precise staging assessments.MethodsThis study included a total of 267 colorectal cancer patients (training cohort: n = 213; testing cohort: n = 54). Logistic regression algorithms were used to construct the models. The HE image features were used to build the HE model, the Ki67 image features were used for the Ki67 model, and the combined model included features from both the HE and Ki67 images, as well as tumor markers (CEA, CA724, CA125, and CA242). The predictive results of the HE model, Ki67 model, and tumor markers were visualized through a nomogram. The models were evaluated using ROC curve analysis, and their clinical value was estimated using decision curve analysis (DCA).ResultsA total of 260 deep learning features were extracted from HE or Ki67 images. The AUC for the HE model and Ki67 model in the training cohort was 0.885 and 0.890, and in the testing cohort, it was 0.703 and 0.767, respectively. The combined model and nomogram in the training cohort had AUC values of 0.907 and 0.926, and in the testing cohort, they had AUC values of 0.814 and 0.817. In clinical DCA, the net benefit of the Ki67 model was superior to the HE model. The combined model and nomogram showed significantly higher net benefits compared to the individual HE model or Ki67 model.ConclusionThe combined model and nomogram, which integrate pathomics multi‐modal data and clinical‐pathological variables, demonstrated superior performance in distinguishing between Stage I–II and Stage III colorectal cancer. This provides valuable support for clinical decision‐making and may improve treatment strategies and patient prognosis. Furthermore, the use of immunohistochemistry (Ki67) slides for pathomics modeling outperformed HE slide, offering new insights for future pathomics research.