bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA GATA6-AS1 is mediated by N6-methyladenosine methylation and inhibits the proliferation and metastasis of gastric cancer
Authors: Shen Jun-Jie , Li Min-Chang , Tian Shao-Qi , Chen Wen-Ming 
Published: March 2024

BACKGROUND
Through experimental research on the biological function of GATA6-AS1, it was confirmed that GATA6-AS1 can inhibit the proliferation, invasion, and migration of gastric cancer cells, suggesting that GATA6-AS1 plays a role as an anti-oncogene in the occurrence and development of gastric cancer. Further experiments confirmed that the overexpression of fat mass and obesity-associated protein (FTO) inhibited the expression of GATA6-AS1, thereby promoting the occurrence and development of gastric cancer.
AIM
To investigate the effects of GATA6-AS1 on the proliferation, invasion and migration of gastric cancer cells and its mechanism of action.
METHODS
We used bioinformatics methods to analyze the Cancer Genome Atlas (https://portal.gdc.cancer.gov/ . The Cancer Genome Atlas) and download expression data for GATA6-AS1 in gastric cancer tissue and normal tissue. We also constructed a GATA6-AS1 lentivirus overexpression vector which was transfected into gastric cancer cells to investigate its effects on proliferation, migration and invasion, and thereby clarify the expression of GATA6-AS1 in gastric cancer and its biological role in the genesis and development of gastric cancer. Next, we used a database (http://starbase.sysu.edu.cn/starbase2/ ) to analysis GATA6-AS1 whether by m6A methylation modify regulation and predict the methyltransferases that may methylate GATA6-AS1. Furthermore, RNA immunoprecipitation experiments confirmed that GATA6-AS1 was able to bind to the m6A methylation modification enzyme. These data allowed us to clarify the ability of m6A methylase to influence the action of GATA6-AS1 and its role in the occurrence and development of gastric cancer.
RESULTS
Low expression levels of GATA6-AS1 were detected in gastric cancer. We also determined the effects of GATA6-AS1 overexpression on the biological function of gastric cancer cells. GATA6-AS1 had strong binding ability with the m6A demethylase FTO, which was expressed at high levels in gastric cancer and negatively correlated with the expression of GATA6-AS1. Following transfection with siRNA to knock down the expression of FTO, the expression levels of GATA6-AS1 were up-regulated. Finally, the proliferation, migration and invasion of gastric cancer cells were all inhibited following the knockdown of FTO expression.
CONCLUSION
During the occurrence and development of gastric cancer, the overexpression of FTO may inhibit the expression of GATA6-AS1, thus promoting the proliferation and metastasis of gastric cancer.
Adolescents’ Perspective Regarding a Community-Wide Mass Drug Administration Program for Soil-Transmitted Helminths in India
Authors: Aruldas Kumudha , Johnson Jabaselvi , Saxena Malvika , Titus Angelin , Roll Amy , Ramesh Rohan Michael , Walson Judd L. , Means Arianna Rubin , Ajjampur Sitara Swarna Rao 
Published: March 2024

ABSTRACT.
This study was undertaken to understand the perspective of adolescents in endemic communities of India regarding soil-transmitted helminth (STH) infections and community-wide mass drug administration (cMDA). A multicountry community-based cluster-randomized trial, the Deworm3 trial, tested the feasibility of interrupting STH transmission with cMDA, where all individuals aged 1–99 are treated empirically with albendazole. Using a guideline based on the Consolidated Framework for Implementation Research, eight focus group discussions were conducted among 57 adolescents from the trial site in India and analyzed on ATLAS.ti 8.0 software using an a priori thematic codebook. Adolescents believed that adults could be a source of STH infection because they were not routinely dewormed like the children through the national deworming program. Perceived benefits of cMDA for all were better health and increased work efficiency. Perceived barriers to adults’ participation in cMDA was their mistrust about the program, fear of side effects, perceived low risk of infection, and absence during drug distribution. To encourage adult participation in cMDAs, adolescents suggested community outreach activities, engaging village influencers and health workers, and tailoring drug distribution to when adults would be available. Adolescents were confident in their ability to be change agents within their households for treatment compliance. Adolescents provided insights into potential barriers and solutions to improve adult participation in cMDA, identified best practices of cMDA delivery, and suggested that they have unique roles as change agents to increase their household participation in cMDA.
Strategic triangle ‘Russia — India — China’: Structure and problems of interaction
Authors: Zhu Xu 
Published: March 2024

A contemporary world order is based on an increasingly complex system of interstate relations, which implies the need to thoroughly consider the international context, even when analyzing bilateral interactions. From this point of view, the concept of a ‘strategic triangle’, developed during the Cold War and applied primarily to analyze the dynamics of relationships between the USSR, the USA and the PRC, appears to have significant epistemological potential. In current conditions, it is of particular interest to use this concept to study the logic of relations in the ‘Russia–India–China’ (RIC) triangle. This research pursues two interrelated goals. On the one hand, it is aimed at identifying specific features of this new ‘strategic triangle’, its inner structure and logic of interactions between its participants. On the other hand, it assesses the applicability of the theoretical models developed during the Cold War to the relations within the framework of the RIC strategic triangle. The author examines the history, general dynamics and contemporary features of interaction within each pair of bilateral relations in this ‘triangle’. The research has confirmed the hypothesis that the relations between Russia, India, and China, indeed, form a specific subsystem of international relations, which can be described as a ‘strategic triangle’. At the same time, unlike the Sino-American-Soviet ‘strategic triangle’, it is the logic of cooperation, rather than rivalry, which generally prevails within the framework of the RIC.However, the RIC ‘triangle’ can also be described as an inherently inconsistent system. While China and Russia maintain close strategic cooperation in almost all areas, in the case of India and Russia, economic cooperation does not match the achieved level of political contacts, and Sino-Indian relations, despite the generally positive dynamics during the recent years, remain at a low level. All this points to the need to develop a new theoretical and methodological framework for analyzing trilateral relations between Russia, India and China as a special subsystem of the contemporary world politics, one that will be free from Cold War stereotypes.
Understanding The Simpsons
Authors: Fink Moritz 
Published: March 2024

Accolades such as the best TV show of the twentieth century or the longest-running scripted series on American prime-time television have not only elevated The Simpsons to the comedy pantheon, they have come to suggest the very dinosaur character of the program. But the label The Simpsons not just refers to a show that seems to belong to a bygone television era; it implies a rich narrative universe, including a set of iconic figures, familiar across continents and generations.
Through a transmedia-studies lens, Understanding The Simpsons traces the yellow-branded franchise's trajectory, from its original conception shaped by alternative media traditions to its astounding, long-lived impact as a cult phenomenon in popular culture. Examining the legacy of online fan forums and bootleg T-shirts from the show's heyday in the early 1990s, as well as the meaning of The Simpsons in contemporary digital culture, this book demonstrates how one of the most popular comedy series of all times has redefined the intersection between the corporate media and participatory culture – and is alive, indeed.
An Approach to Improving Compliance of Treatment in Asymptomatic Bacteriuria
Authors: Lewis Johnathan , Dye Angelic , Koehler Tracy , Grill Justin , Baribeau Sarah , Bryant Caleb 
Published: March 2024

INTRODUCTION Asymptomatic bacteriuria (ASB) is the presence of bacteria in the urine without attributable signs or symptoms of a urinary tract infection (UTI). This condition is often inappropriately treated per the 2019 Infectious Disease Society of America guidelines. This quality improvement project aimed to reduce improper treatment of ASB via a three-phase spaced repetition approach over a 12-month 2021-2022 period within a Michigan emergency department (ED), targeting 43 ED clinicians. METHODS During Phase I, a 20-minute teleconference educational intervention was delivered by an Infectious Disease physician and pharmacist. During Phase II, a “hard stop” was implemented within the electronic health record preventing reflex urinalysis culture without indication. During Phase III, a latent period of no intervention took place. The authors’ goal was to achieve > 80% compliance to ASB treatment guidelines. RESULTS Overall compliance after the project initiative was 66.7%, an absolute increase of 16.7% from baseline compliance. Using data from 54 patients, this represented a statistically significant (p = 0.01) increase from baseline but fell short of the target of > 80%. DISCUSSION Although the authors fell short of their goal of a 30% increase, data from the project suggests a spaced repetition approach to education and workflow changes could be an effective method to increasing medical provider compliance with treatment of ASB. CONCLUSION Identifying the ideal strategy to change treatment patterns of ED clinicians for ASB to align with guidelines remains key. There is still a need for ongoing efforts in this realm for progress to be made. Keywords: asymptomatic bacteriuria, urinary tract infection, compliance, spaced repetition, antibiotics.
Secondary Postoperative Hemorrhage in the Pediatric Tonsillectomy Patient- is there a correlation between hemorrhage and tonsilloliths?
Authors: Ross Andrew , Mnatsakanian Ani , Markovicz Jacob , Desai Sruti , Anderson Brian , Shifman Holly , Engebretsen Steven , Wentland Carissa , Thottam Prasad , Haupert Michael 
Published: March 2024

INTRODUCTION Tonsillectomy with or without adenoidectomy is one of the most common ambulatory procedures performed in children under 15. One rare yet serious complication of tonsillectomy is postoperative hemorrhage. Chronic tonsillitis, which is an indication for tonsillectomy, has been shown to have an increased risk for postoperative hemorrhage. Tonsilloliths or tonsil stones have been associated with cryptic tonsillitis. This 2020-2021 study examined whether tonsilloliths were a risk factor for post-tonsillectomy hemorrhage in a convenience sample of 187 pediatric patients. METHODS This was a cross-institutional 12-month retrospective cohort study investigating pediatric patients who had undergone tonsillectomy. Exclusion criteria included patients who had received prior airway surgeries (e.g., supraglottoplasty), patients with significant comorbidities such as chromosomal abnormalities or congenital disorders, and patients with pre-existing bleeding disorders. Demographic, clinical, and operative data was extracted from each chart. Postoperative adverse events and bleeding were also recorded. These factors were then compared between the tonsillolith and no tonsillolith patient groups. RESULTS A total of 187 pediatric patients met the inclusion criteria. Seventy-three (39%) of the patients had tonsilloliths and 114 (61%) did not have tonsilloliths at the time of surgery. The tonsillolith subgroup had a higher median age (10 vs 3, P < 0.001) when compared to the no tonsillolith subgroup. The most common indication for tonsillectomy was obstructive sleep apnea/sleep disordered breathing (N= 148, 79.1%). There was no statistical difference found between presence of tonsillolith and indication for surgery (P = 0.06). Only five (2.7%) of sample patients experienced postoperative bleeding and there was no association found between postoperative bleeding and presence of tonsilloliths (P = 0.38). CONCLUSION In the current study there was no association found between the presence of tonsilloliths (indicating low grade chronic inflammation) and hemorrhage after tonsillectomy. Continued larger sample evaluations of possible risk factors for post-tonsillectomy hemorrhage patterns are encouraged.
Multiscale Modeling of Heart Disease and Musculoskeletal Performance
Authors: McCulloch Andrew 
Published: March 2024

Computational modeling in physiology can be integrative in several different ways. In this seminar I will use examples from our research at UC San Diego on heart disease and musculoskeletal performance to illustrate these approaches and how they can be used together. Biophysically based multiscale models integrate structurally across scales of biological organization from molecular to organism. I will show how we have combined atomistic molecular modeling, subcellular scale Markov state models, whole cell systems models with organ and system scale continuum and lumped parameter models to predict therapeutic mechanisms of 2-deoxyATP as a myosin activator in heart failure. Systems modeling of biological networks integrate the functions of biochemical modules into the emergent properties of signaling pathways that regulate genome-scale transcription. I will show how we have applied this approach to elucidate the signaling interactions that control mechanoregulated gene expression in cardiac myocytes. And statistical models and machine learning enabling the development of clinical data integration tools for better diagnosis and management of congenital heart disease and arrhythmias.While our research on the heart has focused on disease mechanisms and pathogenesis, studying trained athletes is giving us new insights into the biological principles underlying elite human performance especially in the musculoskeletal system. I will end with an overview of how we are now applying the modeling and experimental strategies we have used for studying heart disease to understand the effects of exercise training especially on skeletal muscle biology and human movement competency.
Post-partum cerebral venous sinus thrombosis: A case report
Authors: Jain Shruti , Bhushan Mehak , Talwar Vandana 
Published: March 2024

Introduction: Cerebral venous sinus thrombosis (CVST) is a rare and life-threatening condition that may be encountered during pregnancy and puerperium. The diagnosis of CVST is a challenge because of its varied presentation.
Case Report: A 28-year-old woman presented with headache, projectile vomiting, and generalized tonic–clonic seizures 10 days after delivery by cesarean section. She had an uneventful antenatal period of 38 weeks of gestation. High clinical suspicion and the availability of magnetic resonance venography helped in making a diagnosis of CVST. She was successfully managed with a low-molecular-weight heparin (LMWH) and anti-epileptic therapy with no residual complications.
Discussion: Pregnancy induces several prothrombotic changes in the coagulation system that predispose to CVST. These changes persist for six to eight weeks after birth. Infection and cesarean section are the additional risk factors for CVST during puerperium. The symptoms of CVST depend on the sinuses and veins involved, raised intracranial pressure, and the extent of brain parenchymal injury.
Conclusion: Greater awareness of the disease and the availability of imaging modalities have contributed to the early diagnosis and favorable outcomes in these cases. LMWH is the main stay of treatment in this disease.
Model Pendidikan Akhlak dalam Kitab Nashoihul Ibad Karya Syeikh Imam Nawawi Al-bantani
Authors: Sya'diyah Siti Aminatus , Fauzi Ahmad , Maghfiroh Ummi Lailia 
Published: March 2024

Abstract
The importance of developing moral education which includes holistic and sustainable aspects has highlighted attention to the moral education model. The book "Nashoihul Ibad" written by Sheikh Imam Nawawi Al-bantani is widely recognized as one of the main references in efforts to enrich Islamic morals. This research aims to conduct an analysis of the moral education model contained in the book "Nashoihul Ibad". The research method uses library research. The research results explain that moral education in the Nashoihul Ibad book consists of three models: First, moral education by instilling awareness about divinity and its relationship with humans. Second, moral education through the formation of noble attitudes and behavior and relationships with fellow humans. Third, moral education further develops personal qualities including fortitude, honesty, courage and responsibility in a social context.

Keywords: Moral Education, Syeikh Imam Nawawi Al-bantani, Book Nashoihul Ibad

Abstrak
Pentingnya pengembangan pendidikan akhlak yang meliputi aspek holistik dan berkelanjutan telah menyoroti perhatian terhadap model pendidikan akhlak. Kitab "Nashoihul Ibad" yang ditulis oleh Syeikh Imam Nawawi Al-bantani diakui secara luas sebagai salah satu rujukan utama dalam upaya memperkaya akhlak Islam. Penelitian ini bertujuan untuk melakukan analisis terhadap model pendidikan akhlak yang terdapat dalam kitab “Nashoihul Ibad”. Metode penelitian menggunakan kajian kepustakaan (library research). Hasil penelitian menjelaskan bahwa pendidikan akhlak dalam kitab Nashoihul Ibad terdiri dari tiga model: Pertama, pendidikan akhlak dengan menanamkan kesadaran mengenai ketuhanan dan hubungannya dengan manusia. Kedua, pendidikan akhlak melalui pembentukan sikap dan perilaku mulia (noble behavior) dan hubungannya dengan sesama manusia. Ketiga, pendidikan akhlak lebih mengembangkan pada kualitas diri meliputi ketabahan, kejujuran, keberanian, dan tanggung jawab dalam konteks sosial.

Kata Kunci: Pendidikan Akhlak, Syeikh Imam Nawawi Al-bantani, Kitab Nashoihul Ibad
Determinantes da desigualdade de renda no Maranhão: uma interpretação para o período de 2012 a 2019
Authors: Pereira Edyr de Jesus Alves , Brito Alexsandro Sousa , Silva Jadson Pessoa da , Azevedo Vanessa Ragone , Silva Saulo Pinto 
Published: March 2024

Evidências da literatura apontam a informalidade, educação e o nível de inserção econômica feminina como determinantes principais da desigualdade de renda. No Maranhão, o nível de desigualdade de renda mensurada pelo GINI da renda domiciliar per capta de todas as fontes (calculada com base nos microdados da PNADC Anual) demonstra uma reversão da queda iniciada em 2013. Nesse sentido, o artigo objetiva analisar a dinâmica da desigualdade de renda trimestral ao longo de quase uma década, para propor uma interpretação sobre quais são os principais determinantes da dinâmica da desigualdade de renda no Maranhão. Para responder ao problema, procedeu-se a uma análise exploratória de dados. Entre os resultados, destacam-se: a) a informalidade no setor privado, ao invés da informalidade em geral, é o principal determinante da desigualdade de renda no Maranhão, b) a desocupação da força de trabalho feminina foi o segundo mais importante determinante da dinâmica da desigualdade de renda no Maranhão, o período em tela.
Implementação do uso da biometria na entrega de EPI’s em porto privado na cidade de Manaus
Authors: Ferreira Eliane de Melo , Pereira Ketlen Silva de Araújo , Freitas Rosana da Silva , Roberto José Carlos Alves , Almeida Victor da Silva 
Published: March 2024

No que se refere a segurança do trabalho, a Norma Regulamentadora nº 6 regulamenta a execução do trabalho com uso de Equipamentos de Proteção Individual (EPI), sem estar condicionada a setores ou atividades econômicas específicas, e é sobre esta norma e suas tecnologias que será tratado, pois, toda atividade é iniciada com a entrega de equipamentos de proteção individual. Foi observado que o sistema de entrega ainda é muito arcaico e consequentemente falho, devido a entrega ser realizada de forma manual através de ficha que é preenchido depois da entrega do EPI, qual tipo de EPI entregue sendo assinada pelo colaborador, neste caso, a pesquisa foi realizada voltada para o segmento de navegação, porto privado de Manaus. O estudo foi realizado por meio bibliográfico com a utilização de artigos pesquisados no Google acadêmico sobre a entrega de EPI’s por meio de biometria em portos pelo Brasil, a pesquisa também foi descritiva e de natureza quantitativa, nos estudos realizados ficou claro que este meio tecnológico torna a entrega mais eficaz, tendo em vista podem ser inseridos pontos específicos a qual o próprio colaborador pode realizar a retirada do equipamento. No momento da retirada são verificados os dados do colaborador, quais EPI’s já foram entregues, quais ele poderá adquirir, os prazos de validade que estão sendo solicitados e depois de quanto tempo poderá ser solicitado novamente, além disso foi realizada entrevista com alguns técnicos de segurança que trabalham no porto e estes afirmaram que sim, com a implantação da biometria para entrega de EPI’s torna uma forma mais eficaz de proteger a integridade dos colaboradores, além da entrega ser realizada de forma mais adequada possível.
Auditoria e seus benefícios na gestão empresarial para o setor energético
Authors: Costa Ariele Biá da Silva da , Silva Monaliza Brígido da , Batista Regiane Figueiredo , Roberto José Carlos Alves 
Published: March 2024

Esta pesquisa tem como abordagem central sobre a auditoria e seus benefícios na gestão empresarial. Sendo o objetivo desse estudo ressaltar a importância do papel da auditoria e seus benefícios na gestão empresarial no setor energético em destaque na atualidade. Com isso a pesquisa se justifica por demonstrar as contribuições realizadas pela auditoria em suas principais relevâncias através de seus métodos, conceitos e benefícios dos serviços que podem ser alcançados com a auditoria trazendo para a prática uma ferramenta de apoio nas tomadas de decisões da gestão. A pesquisa suscita a notabilidade em conhecer a prática da auditoria para os processos de gestão empresarial e tomadas de decisões nos processos gerenciais. Constatou-se por meio da pesquisa que a auditoria uni benefícios gerais e permite demonstrar sua importância de ser aplicada nas mais diversas áreas da contabilidade para a gestão empresarial como forma de mensurar processos com mais veracidade de conhecimento. Por fim, a auditoria nas organizações assegura identificar novos métodos, promover a elaboração de novas estratégias e maior controle em seus sistemas operacionais e financeiros, em conformidade com as leis e regulamentos aplicáveis em cada caso, além gerar novas oportunidades de aperfeiçoamento para o desempenho das organizações.
تفسير نور الأنوار ومصباح الأسرار للسيد رضي الدين محمد بن محمد تقي الموسوي النجفي الشيرازي (ت 1112هـ) من سورة الحج الآيات (1 – 20) دراسة وتحقيق
Authors: أ. د. علي شكر داود  , الباحث. كاظم عيسى كاظم  
Published: March 2024

يهدف هذا البحث الموسوم (تفسير نور الأنوار ومصباح الأسرار للسيد رضي الدين محمد بن محمد تقي الموسوي النجفي الشيرازي (ت 1112ه) من سور الحج الآيات (1 – 30) .. دراسة وتحقيق) إلى التعريف بواحد من التفاسير المهمة المخزونة في رفوف مكتبات حفظ المخطوطات، حيث إن الخوض في العلم بكتاب الله تعالى من أشرف ما يشتغل به المشتغلون، خصوصاً إذا كان الاشتغال بعلم تفسير القرآن الكريم.
لقد كان للمفسر السيد رضي الدين أسلوب خاص في تفسيره، ويغلب عليه النقل عن الأئمة D، كما أنه يبدأ كل سورة بروايات عن فضل السورة وثواب تلاوتها، وغير ذلك من المميزات التي امتاز بها تفسيره مدار البحث.
ومما تجدر الإشارة إليه أن كثرة التفاسير للقرآن الكريم، منذ نزوله وحتى الآن وستستمر، ما هو إلا دليل على أن القرآن بحر لا ينضب من الفوائد والمعاني المتجددة، كما أن الاختلاف بين المفسرين هو اختلاف تنوع لا تضاد.