bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seltene Differenzialdiagnose bei osteolytischer Läsion des Unterkiefers einer jungen Erwachsenen
Authors: Shin Hyunkyu , Naros Andreas , Kieninger Sinja , Polligkeit Joachim , Fend Falko , Milla Jakob 
Published: April 2024

ZusammenfassungWir stellen einen seltenen Fall mit hämatologischer Neoplasie bei einer jungen Erwachsenen vor, welche zuerst 2008 beschrieben wurde und seit 2022 in beide gängigen Tumorklassifikationssysteme hämatologischer Neoplasien, ICC und WHO, aufgenommen wurde. Diese Neoplasie zeigt eine charakteristische immunhisthochemische ALK-Positivität und entsprechend molekular ein ALK-Fusionsgen. Patholg*innen sollten diese Entität kennen, zumal eine Unterscheidung zwischen dieser Erkrankung und anderen häufiger auftretenden Erkrankungen des gleichen Formenkreises sowie einer mesenchymalen Neoplasie mit ALK-Aberration herausfordernd ist.
Strong Symmetry Breaking in Coupled, Identical Lengyel–Epstein Oscillators via Folded Singularities
Authors: Awal Naziru M. , Epstein Irving R. , Kaper Tasso J. , Vo Theodore 
Published: April 2024

AbstractWe study pairs of symmetrically coupled, identical Lengyel-Epstein oscillators, where the coupling can be through both the fast and slow variables. We find a plethora of strong symmetry breaking rhythms, in which the two oscillators exhibit qualitatively different oscillations, and their amplitudes differ by as much as an order of magnitude. Analysis of the folded singularities in the coupled system shows that a key folded node, located off the symmetry axis, is the primary mechanism responsible for the strong symmetry breaking. Passage through the neighborhood of this folded node can result in splitting between the amplitudes of the oscillators, in which one is constrained to remain of small amplitude, while the other makes a large-amplitude oscillation or a mixed-mode oscillation. The analysis also reveals an organizing center in parameter space, where the system undergoes an asymmetric canard explosion, in which one oscillator exhibits a sequence of limit cycle canards, over an interval of parameter values centered at the explosion point, while the other oscillator executes small amplitude oscillations. Other folded singularities can also impact properties of the strong symmetry breaking rhythms. We contrast these strong symmetry breaking rhythms with asymmetric rhythms that are close to symmetric states, such as in-phase or anti-phase oscillations. In addition to the symmetry breaking rhythms, we also find an explosion of anti-phase limit cycle canards, which mediates the transition from small-amplitude, anti-phase oscillations to large-amplitude, anti-phase oscillations.
Staged neurosurgical approach for giant and progressive neonatal arachnoid cysts: a case series and review of the literature
Authors: Peraud Aurelia , Schuler-Ortoli Marie , Schaal Matthias , Reister Frank , Ehrhardt Harald , Friebe-Hoffmann Ulrike 
Published: April 2024

Abstract
Objectives
Prenatally diagnosed complex arachnoid cysts are very rare. While the true prenatal incidence is still unknown, they account for approximately 1% of intracranial masses in newborns. They rarely exhibit rapid growth or cause obstructive hydrocephalus, but if they increase to such a dimension during pregnancy, the ideal management is not well established. We present our detailed perinatal experience, covering prenatal diagnosis, a compassionate delivery process, and neonatal stabilization. Finally, a thorough postnatal neurosurgical intervention was performed. Initially, our focus was on the gradual reduction of cyst size as a primary effort, followed by subsequent definitive surgical treatment.

Methods
This case series shows the treatment course of three fetuses with antenatally diagnosed large arachnoid cysts. We present pre- and postnatal management and imaging, as well as the surgical treatment plan and the available clinical course during follow-up.

Results
Two girls and one boy were included in the current review. All three cases presented with prenatally diagnosed complex arachnoid cysts that increased in size during pregnancy. The mean gestational age at delivery was 35 weeks (range 32 to 37 weeks), and all patients were delivered by a caesarian section. Increasing head circumference and compression of brain structures were indications for delivery, as they are associated with a high risk of excess intracranial pressures and CSF diapedesis, as well as traumatic delivery and maternal complications. All cysts were supratentorial in location; one expanded into the posterior fossa, and one was a multicompartment cyst. All children underwent an initial surgical procedure within the first days of life. To relieve cyst pressure and achieve a reduction in head circumference, an ultrasound-guided or endoscopic-assisted internal shunt with drainage of the cyst to the ventricles or subdural/subarachnoid space was inserted. Definite surgical therapy consisted of cyst marsupialization and/or cysto-peritoneal shunt implantation. All children survived without severe neurodevelopmental impairments.

Conclusion
With the cases presented, we demonstrate that the slow reduction of immense cyst size as an initial procedure until optimal requirements for final surgical treatment were achieved has proven to be optimal for neurological outcome. Special emphasis has to be taken on the delicate nature of premature newborn babies, and surgical steps have to be thoroughly considered within the interdisciplinary team.
Comparative analysis of linear- and circular-stapled gastrojejunostomies in Roux-en-Y gastric bypass: a focus on postoperative morbidity using the comprehensive complication index
Authors: Sadiku Floni , Alceste Daniela , Serra Michele , Hehl Stefanie Josefine , Gero Daniel , Thalheimer Andreas , Bueter Marco , Widmer Jeannette 
Published: April 2024

Abstract
Purpose
The linear-stapled (LSA) and the circular-stapled anastomosis (CSA) are the two most commonly performed techniques for the gastrojejunostomy (GJ) during laparoscopic Roux-en-Y gastric bypass (RYGB). This study compared the outcome after both techniques with special focus on postoperative morbidity using the comprehensive complication index (CCI).

Methods
Five hundred eighty-eight patients operated between 01/2010 and 12/2019 were included in the final analysis and divided in two cohorts according to the surgical technique of the GJ (LSA (n = 290) or CSA (n = 298)). Before 09/2016, the CSA was exclusively performed for the GJ, while after 09/2016, the LSA was solely used.

Results
The mean CCI for patients with Clavien-Dindo complication grade ≥ 2 within the first 90 days after RYGB was 31 ± 9.1 in the CSA and 25.7 ± 6.8 in the LSA group (p < 0.001), both values still below the previously published benchmark cutoff (≤ 33.73). The C-reactive Protein (CRP)-levels on postoperative days (POD) 1 and 3 as well as the use of opioids on POD 1 were significantly higher in the CSA- than in the LSA-group (all p < 0.001). There were significantly more internal herniations in the CSA group during the first 24 postoperative months (p < 0.001).

Conclusion
Patients after RYGB with CSA were found to have higher CCI values during the first 90 PODs compared to patients in which the LSA was applied. To achieve optimal outcomes in terms of patient morbidity, the LSA seems to be the superior technique for GJ in RYGB.
Long-term quality of life after hybrid robot-assisted and open Ivor Lewis esophagectomy for esophageal cancer in a single center: a comparative analysis
Authors: Neuschütz Kerstin J. , Fourie Lana , Germann Nicolas , Pieters Anouk , Däster Silvio , Angehrn Fiorenzo V. , Klasen Jennifer M. , Müller-Stich Beat P. , Steinemann Daniel C. , Bolli Martin 
Published: April 2024

Abstract
Purpose
Due to improved survival of esophageal cancer patients, long-term quality of life (QoL) is increasingly gaining importance. The aim of this study is to compare QoL outcomes between open Ivor Lewis esophagectomy (Open-E) and a hybrid approach including laparotomy and a robot-assisted thoracic phase (hRob-E). Additionally, a standard group of healthy individuals serves as reference.

Methods
With a median follow-up of 36 months after hRob-E (n = 28) and 40 months after Open-E (n = 43), patients’ QoL was assessed using the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire Core 30 (QLQ-C30) and the EORTC Esophagus specific QoL questionnaire 18 (QLQ-OES18).

Results
Patients showed similar clinical-pathological characteristics, but hRob-E patients had significantly higher ASA scores at surgery (p < 0.001). Patients and healthy controls reported similar global health status and emotional and cognitive functions. However, physical functioning of Open-E patients was significantly reduced compared to healthy controls (p = 0.019). Operated patients reported reduced role and social functioning, fatigue, nausea and vomiting, dyspnea, and diarrhea. A trend towards a better pain score after hRob-E compared to Open-E emerged (p = 0.063). Regarding QLQ-OES18, hRob-E- and Open-E-treated patients similarly reported eating problems, reflux, and troubles swallowing saliva.

Conclusions
The global health status is not impaired after esophagectomy. Despite higher ASA scores, QoL of hRob-E patients is similar to that of patients operated with Open-E. Moreover, patients after hRob-E appear to have a better score regarding physical functioning and a better pain profile than patients after Open-E, indicating a benefit of minimally invasive surgery.
Successful adaptation of twinning concept for global neurosurgery collaborations—a validation study
Authors: Corell Alba , Jabang John N. , Manneh Job , Manneh Ebrima K. , Tisell Magnus , Brandt Christian , Majing Tomas , Smedberg Camilla , Förars Charlotte , Rebucas Sarinah , Goswell Pascal , Ronold Tove , Landén Caroline , Engström Anders , Sorto Pia , Uche Enoch , Wague Daouda , Sakho Youssoupha , Sundblom Jimmy 
Published: April 2024

Abstract

Introduction
Globally, many regions have an urgent, unmet need of neurosurgical care. A multi-step neurosurgical twinning technique, International Neurosurgical Twinning Modeled for Africa (INTIMA), was proved to be successful during a previous mission to Neurosurgical Unit, Enugu, Nigeria. The Swedish African Neurosurgical Collaboration (SANC) performed a developmental mission together with the local neurosurgical unit in The Gambia, adopting the INTIMA model.

Methods
A multidisciplinary team visited for a 2-week collaborative mission at the Neurosurgical Department of the Edward Francis Small Teaching Hospital in Banjul, The Gambia. The mission followed the data of neurosurgical operations during and after the mission as well as about the operations 3 months prior to and after the mission was collected.

Results
During the mission, a total of 22 operations was carried out, the most common being degenerative spinal conditions (n = 9). In the 3 months following the mission, 43 operations were performed compared to 24 during the 3 months leading up to the mission. The complexity of the performed procedures increased after the mission. An operating microscope (Möller-Wedel) was donated and installed and the neurosurgeons on site underwent training in microneurosurgery. The surgical nurses, nurses at the postoperative ward, and the physiotherapists underwent training. A biomedical engineer serviced multiple appliances and devices improving the patient care on site while training local technicians.

Conclusion
This study validated the use of the INTIMA model previously described in a mission by Swedish African Neurosurgical Collaboration (SANC). The model is sustainable and produces notable results. The core strength of the model is in the multidisciplinary team securing all the aspects and steps of the neurosurgical care. Installation of an operating microscope opened for further microsurgical possibilities, improving the neurosurgical care in The Gambia.
Parkinson's disease and vitamins: a focus on vitamin B12
Authors: Rekik Arwa , Santoro Carlo , Poplawska-Domaszewicz Karolina , Qamar Mubasher Ahmad , Batzu Lucia , Landolfo Salvatore , Rota Silvia , Falup-Pecurariu Cristian , Murasan Iulia , Chaudhuri Kallol Ray 
Published: April 2024

AbstractParkinson’s disease (PD) has been linked to a vast array of vitamins among which vitamin B12 (Vit B12) is the most relevant and often investigated specially in the context of intrajejunal levodopa infusion therapy. Vit B12 deficiency, itself, has been reported to cause acute parkinsonism. Nevertheless, concrete mechanisms through which B12 deficiency interacts with PD in terms of pathophysiology, clinical manifestation and progression remains unclear. Recent studies have suggested that Vit B12 deficiency along with the induced hyperhomocysteinemia are correlated with specific PD phenotypes characterized with early postural instability and falls and more rapid motor progression, cognitive impairment, visual hallucinations and autonomic dysfunction. Specific clinical features such as polyneuropathy have also been linked to Vit B12 deficiency specifically in context of intrajejunal levodopa therapy. In this review, we explore the link between Vit B12 and PD in terms of physiopathology regarding dysfunctional neural pathways, neuropathological processes as well as reviewing the major clinical traits of Vit B12 deficiency in PD and Levodopa-mediated neuropathy. Finally, we provide an overview of the therapeutic effect of Vit B12 supplementation in PD and posit a practical guideline for Vit B12 testing and supplementation.
Cellulosic fibers spun from stabilized imidazolium ionic liquids: identification of chromophores in the fibers after accelerated ageing
Authors: Rosenau Thomas , Potthast Antje , Zhang Jiaping , Barbini Stefano , Koide Mitsuharu , Rinner Uwe , Hettegger Hubert 
Published: April 2024

AbstractCellulosic fibers spun from 1,3-dialkylimidazolium ionic liquids are effectively stabilized against cellulose degradation by the addition of antioxidants, but this protective effect comes at the expense of chromophore generation from the degradation products of the stabilizers. In this study, we identified the oxidation and degradation products of four natural antioxidants, α-tocopherol, N-methyl-α-tocopheramine, propyl gallate, and hydroxytyrosol, formed upon accelerated ageing of the fibers. Ageing was performed according to standard protocols under either dry or moist conditions and the extraction was done with supercritical carbon dioxide. Chromophore formation in spinning dope, upon dry ageing and moist ageing were compared. In total, 16 different oxidation/degradation products were isolated, their structure confirmed by comprehensive analytical characterization with full NMR resonance assignment in the 1H and 13C domains as well as by comparison with authentic samples, and their formation pathways discussed. Knowledge of the chemical structures of the degradation products originating from the stabilizers now provides a good starting point for optimization of the fiber bleaching stage.
Graphical abstract
Using a NEAT approach with curriculums for dynamic content generation in video games
Authors: Hind Daniel , Harvey Carlo 
Published: April 2024

AbstractThis paper presents a novel exploration of the use of an evolving neural network approach to generate dynamic content for video games, specifically for a tower defence game. The objective is to employ the NeuroEvolution of Augmenting Topologies (NEAT) technique to train a NEAT neural network as a wave manager to generate enemy waves that challenge the player’s defences. The approach is extended to incorporate NEAT-generated curriculums for tower deployments to gradually increase the difficulty for the generated enemy waves, allowing the neural network to learn incrementally. The approach dynamically adapts to changes in the player’s skill level, providing a more personalised and engaging gaming experience. The quality of the machine-generated waves is evaluated through a blind A/B test with the Games Experience Questionnaire (GEQ), and results are compared with manually designed human waves. The study finds no discernible difference in the reported player experience between AI and human-designed waves. The approach can significantly reduce the time and resources required to design game content while maintaining the quality of the player experience. The approach has the potential to be applied to a range of video game genres and within the design and development process, providing a more personalised and engaging gaming experience for players.
Respiratory outcomes after cleft palate closure in Robin sequence: a retrospective study
Authors: Sullivan Nathaniel A. T. , Lachkar Nadia , Don Griot J. Peter W. , Kruisinga Frea H. , Leeuwenburgh-Pronk Wendela G. , Broers Chantal J. M. , Breugem Corstiaan C. 
Published: April 2024

Abstract
Objectives
There is a paucity of information about the possible risk factors that could identify patients with Robin sequence (RS) who are more prone to developing obstructive airway complications after palate closure. This study aimed to compare the respiratory complication rates in patients with RS and isolated cleft palate (ICP).

Materials and methods
In this retrospective study, we reviewed the medical records of 243 consecutive patients with RS and ICP who were treated at Amsterdam University Medical Centers over the past 25 years. We collected preoperative data on previous treatment, diagnostic findings, surgical technique, weight, and presence of congenital anomalies.

Results
During cleft palate closure, patients with RS were older (11.9 versus 10.1 months; p = 0.001) and had a lower gestational age than those with ICP (37.7 versus 38.5 weeks; p = 0.002). Patients with RS had more respiratory complications (17 versus 5%; p = 0.005), were more often non-electively admitted to the pediatric intensive care unit (PICU) (13 versus 4.1%; p = 0.022), and had a longer hospital stay duration (3.7 versus 2.7 days; p = 0.011) than those with ICP. The identified risk factors for respiratory problems were a history of tongue-lip-adhesion (TLA) (p = 0.007) and a preoperative weight of < 8 kg (p = 0.015). Similar risk factors were identified for PICU admission (p = 0.015 and 0.004, respectively).

Conclusions
The possible risk factors for these outcomes were a low preoperative weight and history of TLA. Closer postoperative surveillance should be considered for patients with these risk factors.

Clinical relevance
Identifying risk factors for respiratory complications could provide clinicians better insight into their patients and allows them to provide optimal care for their patients.
Impact of the COVID-19 pandemic on maxillofacial trauma surgery in Germany - implications from the national DRG database
Authors: Meisgeier Axel , Pienkohs Simon , Moosdorf Laura , Neff Andreas 
Published: April 2024

Abstract
Purpose
The COVID-19 pandemic has affected the personal and social lives of millions of people and also impacted the etiological factors of midfacial trauma such as falls, interpersonal violence or traffic accidents. The aim of this study was to analyze the influence of the COVID-19 pandemic on maxillofacial trauma surgery in the German healthcare system.

Methods
Nationwide data regarding the national diagnosis-related-group (DRG) inpatient billing system used in all German hospitals was received from the German Federal Statistical Office. Various trauma-associated procedures of the Operation and Procedure Classification System (OPS), a German modification of the International Classification of Medical Procedures (ICPM), were statistically associated with different epidemiological factors between 2012 and 2021.

Results
A statistically significant decrease (p < 0.05) in surgeries regarding maxillofacial fractures was registered during the years 2020 and 2021. Young male patients had the largest decline in maxillofacial trauma surgeries during this period (p < 0.05). In contrast. elderly patients 80 years and older showed a dramatic increase in the frequency of fractures in both the midface and the mandible (p < 0.05).

Conclusions
During the COVID 19 pandemic there has been a shift in the number, composition and etiology of maxillofacial fracture surgeries. Measures of social distancing and personal risk avoidance had a societal positive effect on the frequency of facial injuries. This stands in contrast to the drastic increase in fractures of elderly people who should be protected primarily by the measures taken. These results can help to understand these influences better in future pandemics.

Trial registration
German Clinical Trials Register No: DRKS00032778.
A Predictor-Corrector Algorithm for Semidefinite Programming that Uses the Factor Width Cone
Authors: Kirschner Felix , Klerk Etienne de 
Published: April 2024

AbstractWe propose an interior point method (IPM) for solving semidefinite programming problems (SDPs). The standard interior point algorithms used to solve SDPs work in the space of positive semidefinite matrices. Contrary to that the proposed algorithm works in the cone of matrices of constant factor width. We prove global convergence and provide a complexity analysis. Our work is inspired by a series of papers by Ahmadi, Dash, Majumdar and Hall, and builds upon a recent preprint by Roig-Solvas and Sznaier [arXiv:2202.12374, 2022].
The geometry of the vergence-accommodation conflict in mixed reality systems
Authors: Wang Xiaoye Michael , Southwick Daniel , Robinson Ian , Nitsche Michael , Resch Gabby , Mazalek Ali , Welsh Timothy N. 
Published: April 2024

AbstractMixed reality technologies, such as virtual (VR) and augmented (AR) reality, present promising opportunities to advance education and professional training due to their adaptability to diverse contexts. Distortions in the perceived distance in such mediated conditions, however, are well documented and have imposed nontrivial challenges that complicate and limit transferring task performance in a virtual setting to the unmediated reality (UR). One potential source of the distance distortion is the vergence-accommodation conflict—the discrepancy between the depth specified by the eyes’ accommodative state and the angle at which the eyes converge to fixate on a target. The present study involved the use of a manual pointing task in UR, VR, and AR to quantify the magnitude of the potential depth distortion in each modality. Conceptualizing the effect of vergence-accommodation offset as a constant offset to the vergence angle, a model was developed based on the stereoscopic viewing geometry. Different versions of the model were used to fit and predict the behavioral data for all modalities. Results confirmed the validity of the conceptualization of vergence-accommodation as a device-specific vergence offset, which predicted up to 66% of the variance in the data. The fitted parameters indicate that, due to the vergence-accommodation conflict, participants’ vergence angle was driven outwards by approximately 0.2°, which disrupted the stereoscopic viewing geometry and produced distance distortion in VR and AR. The implications of this finding are discussed in the context of developing virtual environments that minimize the effect of depth distortion.