bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal carcinoma: Analysis of management in two medical eras
Authors: Nazarian Homayoun K. , Giuliano Armando E. , Hiatt Jonathan R. 
Published: February 2007

AbstractTrends in presentation, diagnosis, management, and outcome were analyzed for 503 patients with colorectal cancer seen at the UCLA Medical Center between 1960 and 1970 (Group A; n = 210) and 1980 and 1985 (Group B; n = 293). Patients in the latter group exhibited a shift in site to the right side of the colon (18% in Group A vs. 31% in Group B; P < .01), an increase in the number of primary resections without colostomy (38% vs. 61%; P < .01), a lower overall complication rate (28% vs. 18%; P = .01), and a decline in 30‐day mortality (6.2% vs. 2%; P = .01). Although little difference was seen in detection of asymptomatic tumors, earlier lesions were treated in the latter group, accounting for substantially reduced rate of recurrence (69% in Group A vs. 44% in Group B; P < .01). Future management should include an emphasis on earlier detection in order to continue the trend toward enhanced survival. © 1993 Wiley‐Liss, Inc.
Carcinoma of the penis: The Indian experience
Authors: Kamat Murali R. , Kulkarni Jagdeesh N. , Tongaonkar Hemant B. 
Published: February 2007

AbstractA total of 150 evaluable patients with carcinoma of the penis were treated at the Tata Memorial Hospital between 1984 and 1987. The majority of patients were in the 4th to 7th decades. All patients presented with a growth on the penis, the biopsy of which revealed squamous carcinoma. The primary lesions were T1 in 34, T2 in 73, T3 in 41, and T4 in 2 patients, respectively. The inguinal nodes were not palpable (N0) in 77 patients, palpable but histologically not metastatic in 39 patients, and metastatic in 34 patients. The treatment of the primary lesion was surgery in 142 patients and radiation therapy in 8 patients. Patients with nonpalpable nodes were kept under surveillance and those with pathologically metastatic nodes were subjected to bilateral ilioinguinal lymphadenectomy. The size related 5 year survivals were 83.3% for T1 60.4% for T2 and 39.5% for T3 lesions. The 5 year survivals for patients with grade I lesions were 90.3%, for grade II 58.6%, and for grade III 16.7%. The 5 year survival rate for patients for N0 nodes was 75.4% while the 3 year survival rates for patients with N1 and N2 nodes were 40% and 38.8%, respectively. The factors signifying poor survival were perinodal extension and iliac node metastases. There were 8 penile stump recurrences, of which 6 could be salvaged. Metachronous inguinal node metastases developed in 16 patients among whom surgical lymphadenectomy was possible in 12 while 4 had unresectable metastases. © 1993 Wiley‐Liss, Inc.
A suitable model for experimental liver metastasis of human colon cancer xenografts using mice with severe combined immunodeficiency
Authors: Furukawa Toshiharu , Kubota Tetsuro , Watanabe Masahiko , Nishibori Hideki , Kuo Tsong‐Hong , Saikawa Yoshiro , Kase Sugurcj , Tanino Hirokazu , Teramoto Tatsuo , Ishibiki Kyuya , Kitajima Masaki 
Published: February 2007

AbstractStudies on liver metastasis of human colon cancer are limited because of a lack of suitable animal models. In this study, the usefulness of mice with severe combined immunodeficiency (SCID), which congenitally lack functional T and B lymphocytes, was evaluated in comparison with currently available nude mice. Three human colon cancer xenografts transplantable into nude mice were disaggregated enzymatically to obtain tumor cell suspensions, and implanted intrasplenically into SCID and nude mice. The incidence of splenic tumorigenesis and of liver metastases were significantly greater in SCID mice for all xenografts, in comparison with nude mice. In total, 33 of 36 SCID mice and 17 of 43 nude mice developed liver metastases. On the basis of this result, we conclude that SCID mice would be a more suitable model than nude mice for studying liver metastasis of human colon cancer. © 1993 Wiley‐Liss, Inc.
Colorimetric chemosensitivity testing using sulforhodamine B
Authors: Kubota Tetsuro , Takahara Tetsuya , Nagata Midori , Furukawa Toshiharu , Kase Suguru , Tanino Hirokazu , Ishibiki Kyuya , Kitajima Masaki 
Published: February 2007

AbstractA colorimetric chemosensitivity test was investigated using sulforhodamine B (SRB), which stains protein synthesized by cells, as an end‐point marker. Four cultured cell lines, 9 human tumor xenografts serially transplanted into nude mice, and 14 fresh surgical specimens were subjected to this assay. The optimal conditions for the assay were 3–5 × 104 cells per well in a 96‐microplate, an SRB concentration of 4%, and an incubation time of more than 10 minutes. When mitomycin C, doxorubicin, cisplatin, and 5‐fluorouracil were assessed by the SRB assay, the concentration‐effect curves revealed a sharp slope between plateaux at low and high concentrations, suggesting that this assay has an excellent sensitivity which can assess the effect of drugs as “all or none.” Although this high sensitivity resulted in good reproducibility of the assay for cultured cell lines, the predictive rate of the SRB assay for the chemosensitivity of human tumor xenografts in vivo was limited to 63.9%. As a result, this SRB assay is thought to be useful for evaluating the chemosensitivity of cultured cells as all or none, since it can assess directly cellular protein synthesis, which is one of the most important parameters of cell renewal, with excellent sensitivity. © 1993 Wiley‐Liss, Inc.
Major amputation for malignant melanoma: An epidemiological study
Authors: Ebskov Lars Bo 
Published: February 2007

AbstractThe annual number of amputations in Denmark as a consequence of malignant melanoma on the limbs has been constant during the period 1978–1987. In contrast, the number of malignant melanoma localized to the extremities increases. For lower limb amputation the mean age is 58 y for males and for females, 72 y. The sex ratio, male to female is 1:2.2. Of the 13 male amputees 7 (54%) had died after 18 mo, of the 28 female amputees 20 (74%) had died after 19 mo. An analysis (Kaplan‐Meier) shows a 5‐y survival rate of about 28%. The mortality is found to be related to sex and level of amputation. Six cases of upper extremity amputation are presented. A review of the literature in order to compare the demographic factors and to outline the indications for amputation reveals a number of differences, most significantly the higher mean age at time of amputation (about 65 y) in Denmark than the figures earlier published (about 45 y). The consensus seems to be that amputation is rarely indicated except as a form of palliation. © 1993 Wiley‐Liss, Inc.
Relationship between age and the time of surgery and prognosis after gastrectomy for gastric cancer
Authors: Moriguchi Sunao , Maehara Yoshihiko , Korenaga Daisuke , Sugimachi Keizo , Nose Yoshiaki 
Published: February 2007

AbstractWe did a retrospective study to assess the influence of age on the prognosis in 1,537 patients with gastric cancer and who underwent gastrectomy. The patients were classified into 7 groups by age at the time of surgery, and the relative survival rates were calculated after correcting for each patient's sex, age, and the operative calendar year, based on the life table data for the general Japanese population. The overall prognoses in patients under age 30 and over age 80 years were poor (for ages under 30 years, 30–39, 40–49, 50–59, 60–69, 70–79, and over 80 years, the 5‐year survival rates were 32.1%, 55.9%, 54.8%, 54.3%, 48.6%, 50.8%, and 31.5%, respectively). The poor prognoses in the youngest patients could be attributed to a high frequency of aggressive stage of the tumor. After curative gastrectomy, although the prognoses were excellent for every category in the first and second postoperative year, patients over age 80 years had a relatively poor prognosis after the third postoperative check‐up. The poor prognoses in the oldest patients were attributed to the number of deaths due to other diseases. We conclude that for the very young or old subjects, age is a significant prognostic factor for those treated by gastrectomy for gastric cancer. © 1993 Wiley‐Liss, Inc.
Preimmunization of mice with formalinized extracellular antigens of melanoma in combination with IL‐2 and surgical resection increased survival and tumor control in metastatic melanoma model
Authors: Shrayer David , Koness James , Kouttab Nichola , Bogaars Hendrix , Hearing Vincent J. , Gersten Douglas M. , Maizel Abby , Wanebo Harold 
Published: February 2007

AbstractRecently we found that immunization with formalinized extracellular antigens (FECAs) could induce the production of specific antimelanoma antibodies and increase the defense mechanisms of antimelanoma cellular and humoral immunity. In experiments we used pathogen‐free female mice C57BL16 18‐20 g. We injected FECA (0.02 mg of protein/per S.C.— subcutaneous injection) for 1 month, once per week. Concurrently we injected S.C. human recombinant IL‐2: 100 U/g of weight (2,000 U/per mouse). Interleukin‐2 (IL‐2) was injected for 1 month, 5 daydweek. On days 7, 14, 21, and 28 we took retroorbital blood from mice for the study of anti‐FECA and anti‐IL‐2 antibody production with ELISA. Control and experimental mice were then given a subcutaneous injection with 0.5 × lo6 cells B16‐F10 melanoma in 25 p1 into the middle of the tail. By 18 days 100% developed local melanoma tumors. We resected tails of all control and experimental animals 5 mm distal the base of the tail under metaphan anesthesia. The production of antibodies to FECA and IL‐2 started after the 21st day and was higher in the group of mice immunized with FECA and with IL‐2 than in control animals. Combining preimmuni‐zation with FECA and IL‐2 and resection of local melanoma tumors decreased the mortality and the number of mice with local recurrence and metastatic melanoma tumors to the lungs. © 1993 Wiley‐Liss, Inc.
Risk of bilateral cervical lymph node metastases in papillary thyroid cancer
Authors: Noguchi Masakuni , Kinami Shinichi , Kinoshita Kazuo , Kitagawa Hirohisa , Thomas Michaei , Miyazaki Itsuo , Michigishi Takatoshi , Mizukami Yuji 
Published: February 2007

AbstractWe evaluated the risk of bilateral or contralateral cervical lymph node metastases in 135 patients with papillary thyroid cancer who underwent bilateral neck dissection. We confirmed that bilateral jugular lymph node metastases were frequent in patients with obvious carcinoma in both lobes of the gland, in those with cancers arising in the isthmus, in those with clinically detectable bilateral lymphadenopathy, and in those with recurrent thyroid cancer. However, only 24% of the patients who had cancer clinically confined to one lobe with no bilateral or contralateral lymphadenopathy had histologically detected bilateral or contralateral jugular lymph node metastases. But the occurrence of contralateral jugular lymph node metastases was significantly correlated with both clinical lymphadenopathy in the ipsilateral neck and contralateral paratracheal lymph node metastases. Bilateral lymph dissection might be beneficial for these patients. © 1993 Wiley‐Liss, Inc.
Changing role of splenectomy for hematologic disease
Authors: Marble Kimberly R. , Deckers Peter J. , Kern Kenneth A. 
Published: February 2007

AbstractIn the past decade the development of accurate imaging and the evolution of the medical management of hematologic diseases has led to changes in the indications for splenectomy for these disorders. To assess the impact of these developments, a multi‐institutional, retrospective review was undertaken. One hundred fifty‐six splenectomies were performed for hematologic disorders between July 1, 1979 and June 30, 1991. Patients were divided into 2 groups: those undergoing splenectomy from 1979–1985 (Period I), and those undergoing splenectomy from 1986–1991 (Period 11). Diseases were classified into 3 groups: cytopenic/anemic conditions, symptomatic splenomegaly, and Hodgkin's disease. Data was compared between the two periods using chi‐square analysis.More splenectomies were performed for hematologic disorders during Period II than Period I (P < .005). This increase is secondary to a rise in the number of splenectomies performed for cytopenidanemia during Period II. In contrast, splenectomies for splenomegaly and Hodgkin's disease decreased during Period II (P < .005 and < .05). More Hodgkin's patients were upstaged on the basis of positive laparotomy findings in Period II, compared to Period I (40% versus 10%, P = .01).Surgeons are now performing more splenectomies for cytopenic/anemic diseases, and fewer for splenomegaly and Hodgkin's disease. These results are consistent with recent trends: (1) earlier splenectomy in patients with cytopenidanemia; (2) earlier medical intervention in infiltrative splenic disorders; and (3) more reliance on radiologic staging in Hodgkin's disease and widespread use of combination chemotherapy, leaving surgical staging for those cases in which treatment would be changed by laparotomy findings. © 1993 Wiley‐Liss, Inc.
Oral cancer and human papillomaviruses: Is there a link?
Authors: Lakshmi S. , Nair S. Asha , Pillai M. Radhakrishna 
Published: February 2007

AbstractCancer of the oral cavity accounts for almost 56,000 new cases in India each year totalling almost 30% of all cancer cases in the country. Despite the numerous advances in etiology and epidemiology, the mechanisms involved in oral carcinogenesis remain obscure. Current research has provided some provocative results, suggesting an association between human papillomavirus (HPV) and development of squamous cell tumors including oral cancer. Evidence has been presented showing HPV infection of the oral mucosa and its relation to neoplastic changes. However a clear cut association as is evident in the uterine cervix is not yet available. However, considering the many similarities between oral and cervical oncogenesis, many of the HPV induced changes in the cervix may also be applicable to the oral mucosa. This paper studies the evidence for the possible role of HPV infection in oral carcinogenesis, the uterine cervix as a model for HPV mediated carcinogenesis, and tries to determine if similar mechanisms could exist in both cases. © 1993 Wiley‐Liss, Inc.
Oncocytic tumors of salivary gland type: A study with emphasis on nuclear DNA ploidy
Authors: Félix Ana , Fonseca Isabel , Soares Jorge 
Published: February 2007

AbstractWe studied nine cases of oncocytic tumors of salivary gland type in order to evaluate their clinico‐pathologic profiles and nuclear DNA patterns as criteria for the differential diagnosis between benign and malignant forms. The tumors were located at the parotid gland, palate, and orbit. The age of the patients ranged between 35 and 85 years and the sex ratio (F:M) was 1:0.8. Seven tumors were capsulated and typical cytology: they were composed of polyhedrical cells with large, eosinophilic, and granular cytoplasm and dark nucleus. The remaining two tumors exhibited malignancy criteria for the oncocytic tumors: atypia, pleomorphism, and mitosis. The evaluation of the nuclear DNA content was also distinct: benign tumors had a DNA diploid pattern and the malignant neoplasms displayed a DNA aneuploid pattern. These observations point to DNA nuclear assessment as an additional criterion to discriminate neoplasms with divergent clinical behavior and prognosis. © 1993 Wiley‐Liss, Inc.
Preliminary experience with a modified tenckhoff catheter for intraperitoneal chemotherapy
Authors: Nguyen Hoa N. , Averette Hervy E. , Wyble Lindsay , Sevin Bernd‐Uwe , Donato Daniel , Penalver Manuel 
Published: February 2007

AbstractThis study reports our preliminary experience with a modified Tenckhoff catheter for intraperitoneal chemotherapy, primarily designed to be larger, longer, and have more perfusion holes. There were 137 catheters implanted in 125 ovarian cancer patients from June 1988 to December 1990, among which 116 were actually used for intraperitoneal chemotherapy. A total of 559 cycles of intraperitoneal chemotherapy was given with a range of 1 to 16 uses per catheter. There were seven infections (6.0%), four inflow obstructions (3.4%), three bowel perforations (2.6%), and one leakage (0.8%). Among patients with catheter infection, three had delayed bowel perforation. Although the incidence of inflow obstruction was reduced from 5.5 to 3.4%, the improvement did not reach statistical significance. The frequency of delayed bowel perforation and infection were similar to the literature experience of other catheters. An unused catheter should be removed to avoid this serious complication. Further study is needed to evaluate fully the performance of this catheter system. © 1993 Wiley‐Liss, Inc.
Treatment and prognosis of primary thymic carcinoma
Authors: Yano Tokujiro , Hara Nobuyuki , Ichinose Yukito , Asoh Hiroshi , Yokoyama Hideki , Ohta Mitsuo 
Published: February 2007

AbstractFrom 1972 to 1990, we treated eight cases of thymic carcinoma (6 squamous cell and 2 small cell carcinomas). According to the classification by Masaoka et al., they consisted of one stage I, four stage III, one stage IVa, and two stage IVb. A complete resection of the primary tumor could be done in only three patients; the others had diagnostic biopsy and then radiation treatment. Four of five patients had a prolonged regression of the primary tumors after irradiation at 40‐61.2 Gy. Six patients suffered from extrathoracic metastases. All patients received systemic chemotherapy with different regimens to counter either metastatic or locally recurrent lesions. Only two patients (with a regimen including cyclophosphamide, doxorubicin, and vincristine) obtained a partial response. The median survival of the eight patients was 70 months after surgical operation. The identification of an effective drug combination may thus improve the long‐term prognosis of thymic carcinoma since radiotherapy is able to control primary lesions, even in the case of unresectable advanced disease. © 1993 Wiley‐Liss, Inc.
Intraperitoneal cisplatin with sodium thiosulfate protection in rats with intestinal anastomoses
Authors: Wile Alan G. , Dileo Stephanie K. , Gossett Denise A. , Lao Xiao Y. 
Published: February 2007

AbstractIntraperitoneal (IP) cisplatin administered at the time of intraabdominal malignancies such as gastric cancer may prevent or delay intraabdominal recurrence. Perioperative IP cisplatin raises concerns regarding systemic toxicity and retardation of wound healing. Systemic cisplatin toxicity may be reduced by administering its antidote, sodium thiosulfate (STS). A preclinical study of IP cisplatin in rats undergoing a small intestinal anastomosis was carried out. All animals that had received only cisplatin died in the postoperative period as a consequence of cisplating toxicity. Tensile strength of the intestinal anastomoses was determined on the tenth postoperative day in the surviving animals. Animals that had received intravenous (IV) cisplatin with STS had significantly lower tensile strengths than both those receiving IP cisplatin with STS and STS alone. This study demonstrates the safety of perioperative cisplatin with STS protection by the avoidance of systemic toxicity and minimizing the cisplatin‐related retardation of wound healing. © 1993 Wiley‐Liss, Inc.
Evaluation of the current incidence of nodal metastasis from prostate cancer
Authors: Bundrick W. Stewart , Culkin Daniel J. , Mata John A. , Zitman Rogeri I. , Venable Dennis D. 
Published: February 2007

AbstractTo determine the influences of transrectal ultrasonography, prostate‐specific antigen (PSA), and heightened public awarencess of prostate cancer stage at diagnosis, we prospectively evaluated our most recent 173 patients who had a pelvic lymphadenectomy from 1987 to 1991. All patients had clinically localized prostate cancer and underwent bilateral limited pelvic lymph node dissections (N = 173); 19 (10.7%) were found to have nodal metastasis. Pathologic tumor stage and grade information was available for 168 patients who had a simultaneous radical prostatectomy. Clinical T‐stage data revealed that only one patient had a T3 lesion. Pathologic T stage showed 7.1% to be T1a (12/168), 4.1% to be T1b (7/168), 13.7% to be T2a (23/168), 34.5% to be T2b (58/168), and 40.5% to be T3 lesions (68/168). Metastatic nodal involvement was not seen in any T1a, T1b, or T2a lesions. A Gleason's score of less than 5 lesions was predictive of no nodal metastasis. The clinical stage was upstaged pathologically in none of the T1a, 16.7% of the clinical T1b, 75% of the T2a, and 73% of the T2b, lesions. With regard to serum PSA, 27% of those patients with a level > 20 ng/ml had nodal metastasis (6/22) in this series. Although an elevated PSA was not predictive of tumor nodal metastasis, no patient with a normal PSA had nodal metastasis. Although the distribution of pathologic T stages is similar to that reported in the literature, our low incidence of nodal metastasis may suggest that prostate cancer is being diagnosed earlier. © 1993 Wiley‐Liss, Inc.
Resection margin in patients with gastric cancer associated with esophageal invasion: Clinicopathological study
Authors: Yokota Takashi , Sawai Kiyoshi , Yamaguchi Toshiharu , Taniguchi Hiroki , Shimada Shinya , Yoneyama Chihiro , Takahashi Toshio 
Published: February 2007

AbstractWe investigated the correlations between resection margin involvement by carcinoma and a number of clinicopathological features in patients with gastric cancer and esophageal invasion. From January 1968 to December 1988, 1,040 patients with carcinoma of the stomach underwent gastric resection. Thirty‐nine patients had tumor infiltration of the esophagus on histological examination of the resected specimens. The patients were divided into two groups on microscopic examination: those in whom the resection margin was less than 5 mm wide, and those in whom it exceeded 5 mm microscopically. There were 6 and 33 patients in the narrow and wide margin groups, respectively. There were statistically significant differences in tumor size, depth of cancer invasion, and macroscopic appearance between the two groups. The risk of resection margin involvement was high in tumors with the following features: large Borrmann type 4 tumor (macroscopic appearance and size) and infiltrative carcinoma (depth of invasion). © 1993 Wiley‐Liss, Inc.
Limb‐sparing treatment with surgery and intraoperative radiotherapy (IORT) for a second local recurrence of myxoid liposarcoma in the popliteal region, after previous surgery and high‐dose radiation
Authors: Wijffels Robbert T. M. , Mehta Dinesh M. , Spauwen Paul H. M. , Hoekstra Harald J. 
Published: February 2007

AbstractA 46‐year‐old man with a second local recurrence of a myxoid liposarcoma in the fossa poplitea, after surgery and high‐dose external beam radiotherapy, was successfully treated by a limb‐sparing procedure combining marginal excision, intraoperative radiotherapy and reconstructive surgery. After a 48‐month follow‐up, there was no evidence of disease, and the function of the leg and knee was normal. © 1993 Wiley‐Liss, Inc.