bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can biomarkers play a role in the decision about treatment of the clinically negative neck in patients with head and neck cancer?
Authors: Takes Robert P. , Rinaldo Alessandra , Pablo Rodrigo Juan , Devaney Kenneth O. , Fagan Johannes J. , Ferlito Alfio 
Published: January 2008

AbstractFor most patients with head and neck squamous cell cancer, a treatment decision concerning the neck is required. Since detection of small metastases in lymph nodes is difficult, many of the patients with no detectable metastases receive elective treatment of the neck. Additional information on the metastatic potential of the primary tumor before treatment may be useful to reduce the number of these elective procedures. Biomarkers may supply such information. Molecules involved in several pathways have been studied, but the complexity of the metastatic process makes it unlikely that a single marker for metastasis can de identified. Techniques allowing the study of many factors simultaneously seem to be the most promising ones. In recent years, microarray expression profiling and comparative genomic hybridization studies have yielded interesting results. If these results can be confirmed in larger studies, they may play a role in future clinical decision making on treatment of the clinically N0 neck. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Increased midsagittal tongue velocity as indication of articulatory compensation in patients with lateral partial glossectomies
Authors: Rastadmehr Orchid , Bressmann Tim , Smyth Ron , Irish Jonathan C. 
Published: January 2008

AbstractBackgroundThe purpose of this study was to describe the impact of partial lateral glossectomy on midsagittal tongue movement during speech.MethodsUsing B‐mode ultrasound, the midsagittal tongue movement of 10 patients with lateral partial glossectomy during a standardized reading passage was analyzed before and after surgery. Six normal adults served as control speakers. The main outcome measure was the tongue velocity during speech. The technique of defect reconstruction (local vs flap) was included as a covariate in the analysis.ResultsFollowing the surgery, all patients significantly increased the velocity of the midsagittal tongue movements during the reading passage.ConclusionThe results demonstrated that the patients with partial glossectomy compensated for the lateral tongue resections by increasing the velocity of the residual tongue during speech. The study provides first insights into the biomechanical aspects of spontaneous articulatory compensation following lateral tongue resections. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Heterotrimeric Gαq11 co‐immunoprecipitates with surface‐anchored GRP78 from plasma membranes of α2M*‐stimulated macrophages
Authors: Misra Uma Kant , Pizzo Salvatore Vincent 
Published: January 2008

AbstractWe have previously shown that a fraction of newly expressed GRP78 is translocated to the cell surface in association with the co‐chaperone MTJ‐1. Proteinase and methylamine‐activated α2M (α2M*) bind to cell surface‐associated GRP78 activating phosphoinositide‐specific phospholipase C coupled to a pertussis toxin‐insensitive heterotrimeric G protein, generating IP3/calcium signaling. We have now studied the association of pertussis toxin‐insensitive Gαq11, with GRP78/MTJ‐1 complexes in the plasma membranes of α2M*‐stimulated macrophages. When GRP78 was immunoprecipitated from plasma membranes of macrophages stimulated with α2M*, Gαq11, and MTJ‐1 were co‐precipitated. Likewise Gαq11 and GRP78 co‐immunoprecipitated with MTJ‐1 while GRP78 and MTJ‐1 co‐immunoprecipitated with Gαq11. Silencing GRP78 expression with GRP78 dsRNA or MTJ‐1 with MTJ‐1 dsRNA greatly reduced the levels of Gαq11 co‐precipitated with GRP78 or MTJ‐1. In conclusion, we show here that plasma membrane‐associated GRP78 is coupled to pertussis toxin‐insensitive Gαq11 and forms a ternary signaling complex with MTJ‐1. J. Cell. Biochem. 104: 96–104, 2008. © 2008 Wiley‐Liss, Inc.
Reactivity of alkylated phosphorothionates with steel: a tribological and surface‐analytical study
Authors: Heuberger Roman , Rossi Antonella , Spencer Nicholas D. 
Published: January 2008

AbstractPhosphorothionates are anti‐wear lubricant additives and potential replacements for zinc dialkyldithiophosphates. In this study, ball‐on‐disc tests have been carried out combinatorially under extreme pressure (EP) conditions (100–350 MPa at 10 N load). The tests were performed in oil containing triphenyl phosphorothionates substituted with alkyl chains of different lengths. Imaging, small‐area and angle‐resolved X‐ray photoelectron spectroscopy were performed following the tribotest to probe the modification, removal and growth of the surface film. The films were composed, depending on the test conditions, of (i) iron phosphate, (ii) iron phosphates with sulphates or (iii) a mixture of iron phosphates with sulphides and sulphates. With increasing load, the dimensional wear coefficients decreased. Upon increasing temperature from 30 to 150°C, the wear became more severe. These findings suggest the formation of a tribochemical film with some EP performance, despite the severe tribological test conditions applied in this work. Copyright © 2008 John Wiley & Sons, Ltd.
Chitosan Biotinylation and Electrodeposition for Selective Protein Assembly
Authors: Shi Xiao‐Wen , Liu Yi , Lewandowski Angela T. , Wu Li‐Qun , Wu Hsuan‐Chen , Ghodssi Reza , Rubloff Gary W. , Bentley William E. , Payne Gregory F. 
Published: January 2008

AbstractAn alternative route to protein assembly at surfaces based on using the unique capabilities of biological materials for the spatially selective assembly of proteins is described. Specifically, the stimuli‐responsive properties of aminopolysaccharide chitosan are combined with the molecular‐recognition capabilities of biotin‐streptavidin binding. Biotinylated chitosan retains its stimuli‐responsive properties and is capable of electrodepositing at specific electrode addresses. Once deposited, it is capable of binding streptavidin, which can mediate the subsequent assembly of biotinylated proteins. Spatially selective protein assembly using biotinylated Protein A and fluorescently‐labeled antibodies is demonstrated.magnified image
Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development
Authors: Webster Dean C. 
Published: January 2008

AbstractCombinatorial and high‐throughput experimentation is used to accelerate the rate of experimentation in macromolecular science. Combinatorial and high‐throughput methods are used in macromolecular science to discover and optimize catalysts for polymerization reactions, discover compositions that have specific desired properties, and systematically explore polymer structure–property relationships. The use of high‐throughput methods can enable the discovery of complex catalyst systems or polymer compositions that would not be feasible using conventional experimental methods. In addition, combinatorial data can be used as inputs into computer models to enable the accurate prediction of material properties as a function of composition.magnified image
Characterization of Solution‐Processed Double‐Walled Carbon Nanotube/Poly(vinylidene fluoride) Nanocomposites
Authors: Almasri Atheer , Ounaies Zoubeida , Kim Yeon Seok , Grunlan Jaime 
Published: January 2008

AbstractDispersion of CNTs in polymers can yield impressive property enhancements at low volume fractions, thus maintaining the inherent processability of the polymer. In particular, they can improve the electromechanical response of piezoelectric polymers by lowering the actuation voltage and increasing strain and stress response. In this work, piezoelectric PVDF and DWNTs are solution‐cast into films. SEM of fracture surfaces confirms good dispersion, and electrical conductivity measurements reveal a low percolation threshold (0.23 vol.‐%). The effect of CNTs on storage modulus, Tc, Tm and Tg of PVDF is studied. Electromechanical strain is observed at low actuation voltages, possibly due to enhanced local electric field in the presence of DWNTs.magnified image
Short Palm Tree Fibers Polyolefin Composites: Effect of Filler Content and Coupling Agent on Physical Properties
Authors: Bendahou Abdelkader , Kaddami Hamid , Sautereau Henry , Raihane Mustapha , Erchiqui Fouad , Dufresne Alain 
Published: January 2008

AbstractShort date palm tree lignocellulosic fibers have been used as a reinforcing phase in commodity thermoplastic matrices [poly(propylene) and low density polyethylene]. Compatibilization of the fibers was carried out with the use of maleic anhydride copolymers. The morphology, thermal and mechanical properties of the resulting composites were characterized using SEM, DSC and tensile tests. The reinforcing capability of the unmodified fibers was found to depend on the nature of the matrix and the main parameter governing the composite behavior was the degree of crystallinity of the matrix. Compatibilization was reported to enhance the mechanical performances for both sets of composites up to a critical amount of compatibilizer beyond which the degree of crystallinity of the matrix decreases.magnified image
Abnormal Transmittance of Refractive‐Index‐Modified ZnO/Organic Hybrid Films
Authors: Tsuzuki Takuya 
Published: January 2008

AbstractThe refractive index of ZnO/organic nanocomposite films was modified in the range from 1.44 to 1.55, while maintaining high visible transparency. The transparency of the nanocomposite films showed an abnormal behaviour as a function of the loading level of inorganic particles, because it did not decrease according to the Beer‐Lambert law, but rather saturated to a near‐constant value at high particle loading levels above ≈8 vol.‐%. On the other hand, the refractive index of the film showed good agreement with the Bruggemann model, linearly increased as particle concentration increased. This result indicates the possibility of fabricating highly transparent nanocomposite films with controlled refractive indices.magnified image
A Block Copolymer for Functionalisation of Polymersome Surfaces
Authors: van Dongen Stijn F. M. , Nallani Madhavan , Schoffelen Sanne , Cornelissen Jeroen J. L. M. , Nolte Roeland J. M. , van Hest Jan C. M. 
Published: January 2008

AbstractA block copolymer was designed to functionalise the surface of polystyrene‐based polymersomes via coaggregation. An α,ω‐diacetylene‐functionalised poly(ethylene glycol) (PEG) was coupled to an azide‐terminated polystyrene via a Cu(I)‐catalysed cycloaddition to produce a PS‐b‐PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this ‘anchor’ compound in the bilayer of a polymersome places its bio‐orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azido‐functionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.magnified image
Cellular Uptake of DNA Block Copolymer Micelles with Different Shapes
Authors: Alemdaroglu Fikri E. , Alemdaroglu N. Ceren , Langguth Peter , Herrmann Andreas 
Published: January 2008

AbstractThe cellular uptake of DNA block copolymer micelles composed of DNA‐b‐PPO in Caco‐2 cells was studied. In particular it was investigated if the shape of micelle aggregates influences the internalization. Rod‐like polymeric particles were taken up 12 times more efficiently than their spherical counter parts although they were composed of the same constituents. Furthermore, it was observed that internalization of all the micelle systems was more efficient than the pristine DNA controls. A cytotoxicity assay proved the non‐toxic nature of DNA‐b‐PPO micelle aggregates.magnified image
Responsive Backbones Based on Alternating Triazole‐Pyridine/Benzene Copolymers: From Helically Folding Polymers to Metallosupramolecularly Crosslinked Gels
Authors: Meudtner Robert M. , Hecht Stefan 
Published: January 2008

AbstractStep‐growth polymerization using Cu‐catalyzed 1,3‐dipolar cycloaddition reactions, commonly referred to as “click chemistry,” has been used to prepare poly[(1,2,3‐triazol‐4‐yl‐1,3‐pyridine)‐alt‐(1,2,3‐triazol‐1‐yl‐1,3‐phenylene)]s. The recently discovered strong preference of the 2,6‐bis(1,2,3‐triazol‐4‐yl)pyridine (BTP) subunits to adopt an anti–anti conformation enables the extended heteroaromatic polymer strands to adopt a helical conformation, as shown by circular dichroism (CD) spectroscopy. Addition of various transition metal ions leads to coordinative crosslinking and therefore efficient gelation of the polymer solutions. The integration of the BTP scaffold in the main chain of the described polymers illustrates a synthetically inspired approach to readily access new functional macromolecules with potential applications as sensing and magnetic/emissive materials.magnified image
Facile Fabrication of Monolayered Hollow Submicrospheres of PANI on Surfaces of Modified Polymer Films
Authors: Zhong Wenbin , Wang Yongxin , Yan Yan , Yang Wantai 
Published: January 2008

AbstractSummary: A novel strategy was developed in order to prepare monolayered polyaniline (PANI) submicrospheres on polymer substrates. The strategy involved two main steps, i.e., photografting of acrylate acid (AA) onto the surface of a polypropylene (PP) film, and subsequent oxidative polymerization of aniline on the grafted surface. It was found that the PANI monolayered hollow submicrospheres were immobilized on the surface of the PP film when the molar ratio of AA to aniline was about 1:1.6. A possible formation mechanism of the hollow PANI submicrosphere iss discussed.
Microsurgical reconstruction of obstetric brachial plexus palsy
Authors: Chen Liang , Gu Yu‐Dong , Wang Huan 
Published: January 2008

AbstractThe incidence of obstetric brachial plexus palsy is not declining. Heavy birth weight of the infant and breech delivery are considered two important risk factors and Caesarean section delivery seems to be a protective factor. There are two clinical appearances, that is, paralysis of the upper roots and that of total roots, and Klumpke's palsy involving the C8 and T1 roots is rarely seen. Computed tomography myelography (CTM) is still the best way of visualizing nerve roots. Surgical intervention is needed for 20–25% of all patients and clinical information is decisive for the indication of surgery. Most often, a conducting neuroma of the upper trunk is encountered, and it is believed that neuroma resection followed by microsurgical reconstruction of the brachial plexus gives the best results. © 2008 Wiley‐Liss, Inc. Microsurgery, 2008.
Expression and localization of the µ‐opioid receptor (MOR) in the equine cumulus–oocyte complex and its involvement in the seasonal regulation of oocyte meiotic competence
Authors: Dell'Aquila Maria Elena , Albrizio Maria , Guaricci Antonio Ciro , De Santis Teresa , Maritato Filippo , Tremoleda Jordi L. , Colenbrander Ben , Guerra Lorenzo , Casavola Valeria , Minoia Paolo 
Published: January 2008

AbstractThe µ‐opioid receptor (MOR) was identified in equine oocytes, cumulus and granulosa cells. By RT‐PCR, a 441bp fragment was observed. By immunoblotting, a 65 kDa band was detected in samples of winter anestrous whereas in cells recovered in breeding season, two bands, 65 and 50 kDa, were found. The 65 kDa band was significantly more intense in winter anestrous specimens. In samples recovered in the breeding season, this band significantly decreased with the raise of follicle size and was heavier in compact oocytes and cumulus cells. The protein was localized on the oolemma and within the cytoplasm of oocytes and cumulus cells. In vitro oocyte maturation rate (MR), analyzed by confocal microscopy for nuclear chromatin, microfilaments and microtubules, was reduced after the addition of 3 × 10−8 M β‐endorphin in medium without additional hormones. Inhibitory effects of 10−3 M Naloxone in oocytes collected in anestrous and spring transition were observed, both in presence and absence of hormones added to culture medium. Increased MRs were observed in oocytes collected in anestrous and cultured in presence of 10−8 M Naloxone. The exposure to 10−3 M Naloxone induced significant intracellular calcium increases in cumulus cells recovered all over the year. β‐Endorphin 3 × 10−8 M induced significant calcium increases only in cumulus cells recovered in fall transition and anestrous. Naloxone 10−8 M did not induce intracellular calcium modifications. We conclude that the MOR is differentially expressed in equine cumulus–oocyte complexes in the different seasons of the year and plays a role in the seasonal regulation of meiotic competence of equine oocytes. Mol. Reprod. Dev. 75: 1229–1246, 2008. © 2008 Wiley‐Liss, Inc.
Effect of local neutralization of basic fibroblast growth factor or vascular endothelial growth factor by a specific antibody on the development of the corpus luteum in the cow
Authors: Yamashita Hiromichi , Kamada Daichi , Shirasuna Koumei , Matsui Motozumi , Shimizu Takashi , Kida Katsuya , Berisha Bajram , Schams Dieter , Miyamoto Akio 
Published: January 2008

AbstractActive angiogenesis and progesterone (P) synthesis occur in parallel during development of the corpus luteum (CL). Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are known to stimulate angiogenesis and P synthesis in vitro. The aim of the present study was to investigate the impact of bFGF or VEGF on the CL development in the cow by using a specific antibody against bFGF or VEGF. bFGF antibody, VEGF antibody, or saline as a control (n = 4 cows/treatment) were injected directly into the CL immediately after ovulation (Day 1), and the treatment was continued for 3 times/day over 7 days. Luteal biopsies were applied on Day 8 of the estrous cycle to determine the expression of genes associated with P synthesis and angiogenesis. Intraluteal injections with the bFGF antibody or the VEGF antibody markedly decreased the CL volume, plasma P concentration and StAR mRNA expression. bFGF antibody treatment decreased the mRNA expression of bFGF, FGF receptor‐1, VEGF120, and angiopoietin (ANPT)‐1, and increased ANPT‐2/ANPT‐1 ratio. However, VEGF antibody treatment decreased ANPT‐2 mRNA expression and ANPT‐2/ANPT‐1 ratio. These results indicate that local neutralization of bFGF or VEGF changes genes regulating angiogenesis and P synthesis, and remarkably suppresses the CL size and P secretion during the development of CL in the cow, supporting the concept that bFGF and VEGF control the CL formation and function. Mol. Reprod. Dev. 75: 1449–1456, 2008. © 2008 Wiley‐Liss, Inc.
Stages of smoking acquisition of young Taiwanese adolescents: Self‐Efficacy and decisional balance
Authors: Chen Huey‐Shys , Horner Sharon D. , Percy Melanie S. , Sheu Jiunn‐Jye 
Published: January 2008

AbstractThe objective of this study was to assess relationships of the stages of smoking acquisition with self‐efficacy and decisional balance in young Taiwanese adolescents. A random sample of 401 students was recruited. Students who were at the precontemplation stage had higher self‐efficacy to resist smoking initiation than those who were at the decision‐making or maintenance stages. Ratings of benefits of smoking were significantly higher for those in the maintenance stage than in the precontemplation or decision‐making stages. In a discriminant function analysis, self‐efficacy and decisional balance correctly predicted 77.4% of membership in the three stages. Health educators could use stage‐specific skills and strategies based on self‐efficacy and decision balance constructs to develop smoking prevention programs. © 2008 Wiley Periodicals, Inc. Res Nurs Health 31:119–129, 2008
Pursuing common agendas: A collaborative model for knowledge translation between research and practice in clinical settings
Authors: Baumbusch Jennifer L. , Kirkham Sheryl Reimer , Khan Koushambhi Basu , McDonald Heather , Semeniuk Pat , Tan Elsie , Anderson Joan M. 
Published: January 2008

AbstractThere is an emerging discourse of knowledge translation that advocates a shift away from unidirectional research utilization and evidence‐based practice models toward more interactive models of knowledge transfer. In this paper, we describe how our participatory approach to knowledge translation developed during an ongoing program of research concerning equitable care for diverse populations. At the core of our approach is a collaborative relationship between researchers and practitioners, which underpins the knowledge translation cycle, and occurs simultaneously with data collection/analysis/synthesis. We discuss lessons learned including: the complexities of translating knowledge within the political landscape of healthcare delivery, the need to negotiate the agendas of researchers and practitioners in a collaborative approach, and the kinds of resources needed to support this process. © 2008 Wiley Periodicals, Inc. Res Nurs Health 31:130–140, 2008
Development and testing of the diabetes self‐management instrument: A confirmatory analysis
Authors: Lin Chiu‐Chu , Anderson Robert M. , Chang Chao‐Sung , Hagerty Bonnie M. , Loveland‐Cherry Carol J. 
Published: January 2008

AbstractThe purpose of this study was to develop and psychometrically test a new instrument for measuring self‐management of adults with type 2 diabetes. Data were collected from 634 diabetic adults recruited from three teaching hospitals in Taiwan. Construct validity was determined by confirmatory factor analysis (CFA). Tests of internal consistency and test–retest were used to assess the reliability of the diabetes self‐management instrument (DSMI). Initial results of CFA did not fully support the proposed five‐factor model. After the model was modified, the fit indices indicated that this model fits the data best. This model was further cross validated in a second sample. Cronbach's alpha coefficient of the DSMI total scale was .94. The test–retest correlations for the DSMI total scale were acceptable (r = .73, p < .01). © 2008 Wiley Periodicals, Inc. Res Nurs Health 31:370–380, 2008
Preparation of interpenetrating polymer network composed of poly(ethylene glycol) and poly(acrylamide) hydrogels as a support of enzyme immobilization
Authors: Lee Yeol , Kim Dae Nyun , Choi Dongkil , Lee Woojin , Park Jinwon , Koh Won‐Gun 
Published: January 2008

AbstractPoly(ethylene glycol)(PEG)‐based interpenetrating polymeric network (IPN) hydrogels were prepared for the application of enzyme immobilization. Poly(acrylamide)(PAAm) was chosen as the other network of IPN hydrogel and different concentration of PAAm networks were incorporated inside the PEG hydrogel to improve the mechanical strength and provide functional groups that covalently bind the enzyme. Formation of IPN hydrogels was confirmed by observing the weight per cent gain of hydrogel after incorporation of PAAm network and by attenuated total reflectance/Fourier transform infrared (ATR/FTIR) analysis. Synthesis of IPN hydrogels with higher PAAm content produced more crosslinked hydrogels with lower water content (WC), smaller Mc and mesh size, which resulted in enhanced mechanical properties compared to the PEG hydrogel. The IPN hydrogels exhibited tensile strength between 0.2 and 1.2 MPa while retaining high levels of hydration (70–81% water). For enzyme immobilization, glucose oxidase (GOX) was immobilized to PEG and IPN hydrogel beads. Enzyme activity studies revealed that although all the hydrogels initially had similar enzymatic activity, enzyme‐immobilizing PEG hydrogels lost most of the enzymatic activity within 2 days due to enzyme leaching while IPN hydrogels maintained a maximum 80% of the initial enzymatic activity over a week due to the covalent linkage between the enzyme and amine groups of PAAm. Copyright © 2008 John Wiley & Sons, Ltd.