bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness Of Platelet Markers In Estimating The Amount Of Intraoperative Bleeding In Vertebra Surgery
Authors: ÇETİNBULUT Seliman , PALABIYIK Onur , KOCAYİGİT Havva , TAŞ TUNA Ayça , CEYLAN Davut 
Published: March 2024

AIMS: One of the most important steps in perioperative bleeding management is the predetermination of the patient at risk. Even if there is no hemostatic abnormality in vertebral surgery, which is a major surgery, severe bleeding can be encountered and many perioperative blood transfusions might be required. To date, there are no studies in the literature examining platelet markers in terms of predictivity in intraoperative bleeding during vertebral surgeries. In this study; we investigated the effectiveness of preoperative mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume lymphocyte count ratio (MPVLR), and platelet count to lymphocyte count ratio (PLR) values in predicting the amount of intraoperative bleeding in patients who will undergo vertebral surgery.
METHODS: After the approval from the ethics committee, patients who were planned for vertebral surgery by the neurosurgeon were identified. Patient demographic data such as gender, age, ASA score and body mass index (BMI), MPV, PDW, PCT, MPVLR, and PLR values were recorded. Total surgery time, the number of vertebral transpedicular screwing, and laminectomy levels performed as surgical procedures were recorded. The amount of intraoperative bleeding was determined by calculating the amount of blood accumulated in the aspirator and the amount of blood collected by the sponge during surgery.
RESULTS: Of the 63 patients included in the study, 60.3% (n=38) were female and 39.7% (n=25) were male. The mean age of the patients was 54.7 ± 11 years and the mean BMI was 29.6 ± 4.6. No correlation was found between the amount of bleeding and gender, age, MPV, PDW, PCT, MPVLR, or PLR values. A significantly high correlation was found between amount of bleeding and BMI, duration of surgery, and the number of transpedicular screwing segments.
CONCLUSION: Platelet markers do not appear to have an effect on the amount of bleeding. However, as the BMI increases, the duration of surgery prolongs and the number of transpedicular screw segments increases for which the amount of bleeding increases.
Automatic detection of thyroid nodules with a real-time artificial intelligence system in a real clinical scenario and the associated influencing factors
Authors: Xu Ya-Dan , Tang Yang , Zhang Qi , Zhao Zheng-Yong , Zhao Chong-Ke , Fan Pei-Li , Jin Yun-Jie , Ji Zheng-Biao , Han Hong , Xu Hui-Xiong , Shi Yi-Lei , Xu Ben-Hua , Li Xiao-Long 
Published: March 2024

BACKGROUND: At present, most articles mainly focused on the diagnosis of thyroid nodules by using artificial intelligence (AI), and there was little research on the detection performance of AI in thyroid nodules. OBJECTIVE: To explore the value of a real-time AI based on computer-aided diagnosis system in the detection of thyroid nodules and to analyze the factors influencing the detection accuracy. METHODS: From June 1, 2022 to December 31, 2023, 224 consecutive patients with 587 thyroid nodules were prospective collected. Based on the detection results determined by two experienced radiologists (both with more than 15 years experience in thyroid diagnosis), the detection ability of thyroid nodules of radiologists with different experience levels (junior radiologist with 1 year experience and senior radiologist with 5 years experience in thyroid diagnosis) and real-time AI were compared. According to the logistic regression analysis, the factors influencing the real-time AI detection of thyroid nodules were analyzed. RESULTS: The detection rate of thyroid nodules by real-time AI was significantly higher than that of junior radiologist ( P = 0.013), but lower than that of senior radiologist ( P = 0.001). Multivariate logistic regression analysis showed that nodules size, superior pole, outside (near carotid artery), close to vessel, echogenicity (isoechoic, hyperechoic, mixed-echoic), morphology (not very regular, irregular), margin (unclear), ACR TI-RADS category 4 and 5 were significant independent influencing factors (all P < 0.05). With the combination of real-time AI and radiologists, junior and senior radiologist increased the detection rate to 97.4% ( P < 0.001) and 99.1% ( P = 0.015) respectively. CONCLUSONS: The real-time AI has good performance in thyroid nodule detection and can be a good auxiliary tool in the clinical work of radiologists.
Predictors of Nursing Home Placement in a Cohort of European People with Alzheimer’s Disease and Other Dementia Cases Enrolled in SCU-B or Non SCU-B Centers: The RECage Study
Authors: Cesana Bruno Mario , Bergh Sverre , Ciccone Alfonso , Cognat Emmanuel , Fabbo Andrea , Fascendini Sara , Frisoni Giovanni B. , Froelich Lutz , Handels Ron , Jori Maria Cristina , Mecocci Patrizia , Merlo Paola , Peters Oliver , Tsolaki Magda , Defanti Carlo Alberto 
Published: March 2024

Background: Nursing home placement (NHP) can be the final step of patients with Alzheimer’s disease. Objective: We aimed to identify NHP predictors among 508 people with dementia with a 3-year follow-up. Methods: We analyzed data from the international observational RECage study, involving 508 people with especially Alzheimer’s disease and comparing a cohort enrolled by five centers with a Special Care Unit for BPSD (behavioral and psychological symptoms of dementia) and another one enrolled by six centers lacking this facility. The tertiary objective of the study was to assess the possible role of the SCU-B in delaying NHP. We assessed the relationship of the baseline characteristics with NHP by means of univariate analysis followed by Cox’s multivariate model. Results: Patients’ mean age was 78.1 years, 54.9% were women. Diagnosis mean age was 75.4 (±8.32) years; the main diagnosis was Alzheimer’s disease (296; 58.4%). During follow-up, 96 (18.9%) patients died and 153 (30.1%) were institutionalized without a statistically significant difference between the two cohorts (p = 0.9626). The mean NHP time was 902 (95% CI: 870–934). The multivariable analysis without death as a competing risk retained four independent predictors of NHP: age increase (hazard ratio (HR) = 1.023, 95% CI: 1.000–1.046), patient education level increase (HR = 1.062, 95% CI: 1.024–1.101), Neuropsychiatric Inventory total increase (HR = 1.018; 95% CI: 1.011–1.026), and total Mini-Mental State Examination as a favorable factor (HR = 0.948, 95% CI: 0.925–0.971). Gender (females versus males: HR = 1.265, 95% CI: 0.899–1.781) was included in the final Cox’s model for adjusting the estimates for. Conclusions: Our data partially agree with the predictors of NHP in literature including the effect of high education level. No caregivers’ factors were statistically significant. Clinical trial registration: NCT03507504.
Alzheimer’s Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis
Authors: Trieu Calvin , van Harten Argonde C. , Leeuwis Anna E. , Exalto Lieza G. , Hooghiemstra Astrid M. , Verberk Inge M.W. , Allaart Cor P. , Brunner-La Rocca Hans-Peter , Kappelle L. Jaap , van Oostenbrugge Robert J. , Biessels Geert-Jan , Teunissen Charlotte E. , van der Flier Wiesje M. ,   on behalf of Heart-Brain Connection Consortium
Published: March 2024

Background: We hypothesize that Alzheimer’s disease (AD)-related pathology may accelerate cognitive decline in patients with cardiovascular diseases. Objective: To investigate the association between blood-based biomarkers of AD, astrocyte activation, and neurodegeneration and cognitive decline. Methods: From the multi-center Heart-Brain study, we included 412 patients with heart failure, carotid occlusive disease or vascular cognitive impairment (age:68.6±9.0) and 128 reference participants (65.7±7.5). Baseline amyloid-β42/40 (Aβ42/40), phosphorylated-tau181 (pTau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) were determined using SiMoA (Quanterix). Memory, attention, language, and executive functioning were evaluated (follow-up:2.1±0.3 years). We applied linear mixed models with terms for biomarker, time and biomarker*time interactions, adjusted for age, sex, education, and site, to assess associations between biomarkers and cognitive decline. Results: Among patients, Aβ42/40 was not associated with cognitive performance at baseline. However, lower Aβ42/40 was associated with steeper decline in global cognition (β±SE:0.04±0.02). Higher pTau181 was associated with worse baseline performance on global cognition (–0.14±0.04) and memory (–0.31±0.09) and with steeper decline in global cognition (–0.07±0.02), memory (–0.09±0.04), attention (–0.05±0.02), and language (–0.10±0.03). Higher GFAP was associated with worse baseline performance on global cognition (–0.22±0.05), memory (–0.43±0.10), attention (–0.14±0.06), language (–0.15±0.05), and executive functioning (–0.15±0.05) and steeper decline in global cognition (–0.05±0.01). Higher NfL was associated with worse baseline performance on global cognition (–0.16±0.04), memory (–0.28±0.09), attention (–0.20±0.06), and executive functioning (-0.10±0.04), but was not associated with performance over time. In reference participants, no associations were found. Conclusions: Our findings suggest that blood-based biomarkers of AD-related pathology predict cognitive decline in patients with cardiovascular diseases.
Neural Computation-Based Methods for the Early Diagnosis and Prognosis of Alzheimer’s Disease Not Using Neuroimaging Biomarkers: A Systematic Review
Authors: Cabrera-León Ylermi , Báez Patricio García , Fernández-López Pablo , Suárez-Araujo Carmen Paz 
Published: March 2024

Background: The growing number of older adults in recent decades has led to more prevalent geriatric diseases, such as strokes and dementia. Therefore, Alzheimer’s disease (AD), as the most common type of dementia, has become more frequent too. Background: Objective: The goals of this work are to present state-of-the-art studies focused on the automatic diagnosis and prognosis of AD and its early stages, mainly mild cognitive impairment, and predicting how the research on this topic may change in the future. Methods: Articles found in the existing literature needed to fulfill several selection criteria. Among others, their classification methods were based on artificial neural networks (ANNs), including deep learning, and data not from brain signals or neuroimaging techniques were used. Considering our selection criteria, 42 articles published in the last decade were finally selected. Results: The most medically significant results are shown. Similar quantities of articles based on shallow and deep ANNs were found. Recurrent neural networks and transformers were common with speech or in longitudinal studies. Convolutional neural networks (CNNs) were popular with gait or combined with others in modular approaches. Above one third of the cross-sectional studies utilized multimodal data. Non-public datasets were frequently used in cross-sectional studies, whereas the opposite in longitudinal ones. The most popular databases were indicated, which will be helpful for future researchers in this field. Conclusions: The introduction of CNNs in the last decade and their superb results with neuroimaging data did not negatively affect the usage of other modalities. In fact, new ones emerged.
POLA PEMASARAN PRODUK DI BANK BRI SYARIAH CABANG PAMEKASAN
Authors: Bahri Mat 
Published: March 2024

Ada dua permasalahan yang menjadi fokus penelitian, yaitu; pertama,bagaimana pola pemasaran produk yang di terapkan di Bank BRI Syariah Cabang Pamekasan.? Kedua, apa pola pemasaran yang efektif di Bank BRI Syariah Cabang Pamekasan.? Penelitian ini termasuk jenis penelitian studi kasus dengan menggunakan pendekatan kualitatif. Sumber datanya adalah ketua pimpinan cabang, manajer marketing, customer service, dan nasabah. Teknik pengumpulan datanya menggunakan observasi, wawancara, dan dokumentasi. Metode analisis datanya adalah metode analisis deskriptif-kualitatif. Dari hasil penelitian, diperoleh temuan bahwa: pertama, pola pemasaran produk di Bank BRI Syariah adalah: seluruh proses dimulai dari analisis pasar mengantarkan produk ke pelanggan dan menerima umpan balik. Prosesnya bertujuan untuk mengetahui pasar yang tepat bagi produk dan penempatannya sedemikian rupa sehingga mendapat respon pelanggan yang baik. Ini mencakup promosi dan penjualan produk ke khalayak sasarannya, yaitu calon pembeli dan pelanggan tetap. Berbagai aktifitas yang terlihat dalam pemasaran produk melibatkan analisis pasar, identifikasi permintaan konsumen, perancangan dan pengembangan produk, penetapan harga, penerapan produk baru, komunikasi, periklanan, penentuan posisi, pendistribusian, penjualan, review dan umpan balik. Kedua, Efektivitas pemasaran yang efektif di Bank BRI Syariah Cabang Pamekasan adalah: perkembangannya cukup baik, mengingat indikator penghargaan yang diraih di ukur dari kinerja keuangan atau perolehan laba perusahaan selama 3 tahun terakhir. Tidak perlu di tanyakan lagi bahwa mengamati seorang pemasar melakukan suatu perilaku yang sering meningkatkan kemungkinan bahwa si pengamat melakukan perintah tersebut. Telah tertulis dalam literatur ekonomi bahwa berbagai situasi pemasaran akan efektif mengubah sebuah pasar.
اثر استخدام تطبيقات التحليل البايوميكانيكي في تصحيح والتطوير الاداء المهاري لحركة الطعن بسلاح الشيش للمبارزة
Authors: Assis  prof .Dr. Serco Muhammad Saleh  
Published: March 2024

ان استعمال الوسائل والاجهزة الحديثة تحرر الطالب او المتعلم من الاساليب المتبعة فضلاً عن الاقتصاد الكبير في الجهد والوقت تماشياً مع سرعة العصر ، ويعد البرمجيات التحليلية احد هذه التقنيات التي يسعى المعلم الى استعمالها في العملية التعليمية في مجالات كافة ومنها مجالنا الرياضي،والهدف من الدراسة، التعرف على بعض المتغيرات البايوكينماتيكية لحركة الطعن لدى عينة البحث، التعرف على تاثير برمجيات التحليل الحركي في تعلم و تصحيح بعض الاخطاء مهاري لحركة الطعن لدى عينة البحث،استخدم الباحث منهج التجريبي لملائمة من طبيعة البحث، يتكون عينة البحث من طالبات مرحلة الرابعة في كلية الترية البدنية وعلوم الرياضة/قسم التربية الاساسية بجامعة السليمانية الذين يدرسون مقرر مادة المبارزة وإجراءات البحث وطرق الحصول على المعلومات، تم استخراج المتغيرات الخاصة بالمهارة الطعن من قبل الباحث عن طريق تطبيق برنامج (kinovea) والذي بعد ان تم تجميع مقاطع التصوير من الكاميرات هو عبارة عن برنامج خاص في مجال البيوميكانيك الرياضي، وايضا تحميل و استخدام البرمجيات التحليل الحركي من قبل الطالبات، آما في الباب الرابع فقد تم عرض النتائج من خلال جدولين وعرض كتابي ومناقشتها وفي الباب الخامس تم عرض الاستنتاجات وأهمها استخدام التحليل الحركي و استخراج البيانات الوصفية لمهارة الطعن يؤثر تاثيرا اجابيا على تحسين و التطوير اداء مهارة الطعن،و اظهرت النتائج بان استخدام التطبيقات التحليل البايوكينماتيكي يؤثر على تحسين والتطوير مهارة الطعن.
التحليل الحاسوبي للنمو الحركي (المشي) على وفق بعض المتغيرات البايوكنماتيكية لأطفال بعمر ٣-٤ سنوات
Authors: Teacher .Dr. Farid Fouad Rasheed  
Published: March 2024

الملخص
ان عملية تطور النمو والمشي للطفل حتى الوصول الى سن البلوغ هي عملية ديناميكية مستمرة يتعرض لها الطفل خلال حياته فتحصل مجموعة من التغيرات المهمة منها معدل سرعة النمو وتطور القدرات الحركية والبدنية الخاصة بنوع النشاط الرياضي الممارس, فمشكلة البحث تضمنت مناقشة الانماط الحركية للطفل بنمط حركة المشي كنموذج متاح للملاحظة والمعالجة الحركية ,حيث يتضمن النموذج الكامل للمشي (متوسط زمن ارتكاز القدمين اثناء المشي ,متوسط زمن الخطوة للقدمين ,متوسط زمن المرجحة للقدمين , متوسط طول الخطوة للقدمين), اما منهجية البحث واجراءاته تتكون عينة البحث من (35 ) طفل بأعمار (3-4) سنوات من روضة (قطر الندى الاهلية) وهي نفس عينة المجتمع البحثي, فقد تم اختيارها بالطريقة العمدية لعدد المحاولات الصحيحة في المشي وفقا للشروط التي وضعها الباحث وهي (المحافظة على خصائص المشي لاكبر عدد من السرعات وعدم الانتقال مبكرا الى حركة .
تم تقسيم عينة البحث الى مجموعتين مجموعة بعمر (3 سنوات) واخرى بعمر (4 سنوات ) حيث تم تحليل( 8 محاولات لكل عمر ) . .واستنتج الباحث امكانية التعرف على المستوى الكمي لدينامكية تطور حركة المشي لدى الاطفال بعمر (3-4) سنوات مع امكانية التعرف على المستوى الكيفي لحركة المشي.
The interplay between HPV, other Sexually Transmissible Infections and genital microbiome on cervical microenvironment (MicroCervixHPV study)
Authors: Gonçalves-Nobre J. Guilherme , Matos Andreia , Carreira Mariana , Santos Ana Carolina , Veiga Luisa Carvalho , Ginete Catarina , Brito Miguel , Pires Marina , Pereira Hermínia , Cardoso Carlos , Bicho Manuel , Bicho Maria Clara 
Published: March 2024

BackgroundThe importance of Cervicovaginal Microbiota in protecting against infections (such as HPV) is already well established, namely through Lactobacillus spp., as well as the mechanism through which HPV leads to Cervical Neoplasia. However, it is not possible to classify HPV as a complete carcinogen. Thus, the importance of exploring Cervicovaginal dysbiosis with the intention of deciphering this interaction with HPV, takes on greater relevance. The main objectives of this study were: 1) Comparison of the MCV composition of women with or without HPV and women with ASCUS or LSIL; 2) Characterization of cytokines present in the vaginal microenvironment; 3) Evaluation of the blood count ratios as prognostic systemic inflammatory biomarkers; 4) Correlation between MCV, HPV serotypes and cytokines.MethodsThis was a retrospective, observational, multicenter, cross-sectional study. CVM analysis was performed by isolation RNA and sequencing on a NGS platform. Cytokine concentrations of CVM were obtained through Multiplex platform. Statistical analysis was performed in SPSS v 26.0. An α of 0.05 was considered statistically significant.ResultsHighlighting the core of the study, CVM types of CST I and CST IV were found to influence the emergence of cervical lesions. Neutrophil-to-Lymphocyte ratio was found to impact the prognosis of ASCUS. Within CVM, Lactobacillus prevent the growth of other CST IV species, while the latter express symbiotic relationships with each other and show affinity for specific HPV serotypes. At last, RANTES chemokine is significantly elevated in cervicovaginal infections.ConclusionThe importance of using vaginal cytokine profiles and CVM is highlighted in the hypothesis of prevention of Cervical Neoplasia development, as well as in its use as a prognostic biomarker. Taken together, these insights are one step closer to personalized medicine.
Alteration in gut microbiota is associated with immune imbalance in Graves’ disease
Authors: Liu Yalei , Tang Shasha , Feng Yu , Xue Binghua , Cheng Chaofei , Su Yong , Wei Wei , Zhang Lijun , Huang Zhoufeng , Shi Xiaoyang , Fang Yuanyuan , Yang Junpeng , Zhang Yun , Deng Xinru , Wang Limin , Ren Hongyan , Wang Chongjian , Yuan Huijuan 
Published: March 2024

BackgroundGraves’ disease (GD), characterized by immune aberration, is associated with gut dysbiosis. Despite the growing interest, substantial evidence detailing the precise impact of gut microbiota on GD’s autoimmune processes remains exceedingly rare.ObjectiveThis study was designed to investigate the influence of gut microbiota on immune dysregulation in GD.MethodsIt encompassed 52 GD patients and 45 healthy controls (HCs), employing flow cytometry and enzyme-linked immunosorbent assay to examine lymphocyte and cytokine profiles, alongside lipopolysaccharide (LPS) levels. Gut microbiota profiles and metabolic features were assessed using 16S rRNA gene sequencing and targeted metabolomics.ResultsOur observations revealed a disturbed B-cell distribution and elevated LPS and pro-inflammatory cytokines in GD patients compared to HCs. Significant differences in gut microbiota composition and a marked deficit in short-chain fatty acid (SCFA)-producing bacteria, including ASV263(Bacteroides), ASV1451(Dialister), and ASV503(Coprococcus), were observed in GD patients. These specific bacteria and SCFAs showed correlations with thyroid autoantibodies, B-cell subsets, and cytokine levels. In vitro studies further showed that LPS notably caused B-cell subsets imbalance, reducing conventional memory B cells while increasing naïve B cells. Additionally, acetate combined with propionate and butyrate showcased immunoregulatory functions, diminishing cytokine production in LPS-stimulated cells.ConclusionOverall, our results highlight the role of gut dysbiosis in contributing to immune dysregulation in GD by affecting lymphocyte status and cytokine production.
Clinical efficacy of probiotics in the treatment of alcoholic liver disease: a systematic review and meta-analysis
Authors: Xiong Shi-Ying , Wu Gui-Sheng , Li Chun , Ma Wenzhe , Luo Huai-Rong 
Published: March 2024

ObjectiveAlcoholic liver disease (ALD) is a liver damage disease caused by long-term heavy drinking. Currently, there is no targeted pharmaceutical intervention available for the treatment of this disease. To address this, this paper evaluates the efficacy and safety of probiotic preparation in treating ALD through conducting a meta-analysis, and provides a valuable insight for clinical decision-making.MethodsA systematic search was conducted across databases, including PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, Wanfang, and CBM from the inception dates to October 15, 2023, to identify clinical randomized controlled trials on probiotic preparations in the treatment of ALD. After the literature underwent screening, data extraction, and quality assessment, RevMan 5.3 and Stata 14.2 were employed for data analysis and processing.ResultsA total of 9 randomized controlled trials fulfilled the inclusion criteria. The results of the meta-analysis showed that probiotic preparation could significantly improve the liver function of patients with alcoholic liver disease compared with the control group. Probiotic intervention led to a significant reduction in the levels of alanine aminotransferase (MD=-13.36,95%CI:-15.80,-10.91;P&lt;0.00001),aspartate aminotransferase (MD=-16.99,95%CI:-20.38,-13.59;P&lt;0.00001),γ-glutamyl transpeptidase (MD=-18.79,95% CI:-28.23,-9.34; P&lt;0.0001). Concurrently, the level of serum albumin (MD=0.19,95% CI:0.02,0.36;P=0.03) was increased. Furthermore, probiotic intervention could also modulate the composition of intestinal flora in patients with alcoholic liver disease, leading to an augmentation in Bifidobacteria and a reduction in Escherichia coli. However, in patients with alcoholic liver disease, probiotic intervention showed no significant effects on total bilirubin (MD=-0.01,95% CI:-0.17,0.15;P=0.91), tumor necrosis factor-α (MD=0.03,95% CI:-0.86,0.92;P=0.94) and interleukin-6 (MD=-5.3,95% CI:-16.04,5.45;P=0.33).ConclusionThe meta-analysis indicates that probiotics can improve liver function in alcoholic liver disease, reduce inflammatory responses, regulate intestinal flora, which have potential value in the treatment of alcoholic liver disease.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023472527.