bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing
Authors: Mekkes Nienke J. , Groot Minke , Hoekstra Eric , de Boer Alyse , Dagkesamanskaia Ekaterina , Bouwman Sander , Wehrens Sophie M. T. , Herbert Megan K. , Wever Dennis D. , Rozemuller Annemieke , Eggen Bart J. L. , Huitinga Inge , Holtman Inge R. 
Published: March 2024

AbstractNeurodegenerative disorders exhibit considerable clinical heterogeneity and are frequently misdiagnosed. This heterogeneity is often neglected and difficult to study. Therefore, innovative data-driven approaches utilizing substantial autopsy cohorts are needed to address this complexity and improve diagnosis, prognosis and fundamental research. We present clinical disease trajectories from 3,042 Netherlands Brain Bank donors, encompassing 84 neuropsychiatric signs and symptoms identified through natural language processing. This unique resource provides valuable new insights into neurodegenerative disorder symptomatology. To illustrate, we identified signs and symptoms that differed between frequently misdiagnosed disorders. In addition, we performed predictive modeling and identified clinical subtypes of various brain disorders, indicative of neural substructures being differently affected. Finally, integrating clinical diagnosis information revealed a substantial proportion of inaccurately diagnosed donors that masquerade as another disorder. The unique datasets allow researchers to study the clinical manifestation of signs and symptoms across neurodegenerative disorders, and identify associated molecular and cellular features.
Liprin-α proteins are master regulators of human presynapse assembly
Authors: Marcó de la Cruz Berta , Campos Joaquín , Molinaro Angela , Xie Xingqiao , Jin Gaowei , Wei Zhiyi , Acuna Claudio , Sterky Fredrik H. 
Published: March 2024

ABSTRACTThe formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly of presynaptic specializations remains unclear. Guided by pioneering work in invertebrates, we hypothesized that in mammalian synapses, liprin-α proteins directly link trans-synaptic initial contacts to downstream steps. Here we show that, in human neurons lacking all four liprin-α isoforms, nascent synaptic contacts are formed but recruitment of active zone components and accumulation of synaptic vesicles is blocked, resulting in ‘empty’ boutons and loss of synaptic transmission. Interactions with presynaptic cell adhesion molecules of either the LAR-RPTP family or neurexins via CASK are required to localize liprin-α to nascent synaptic sites. Liprin-α subsequently recruits presynaptic components via a direct interaction with ELKS proteins. Thus, assembly of human presynaptic terminals is governed by a hierarchical sequence of events in which the recruitment of liprin-α proteins by presynaptic cell adhesion molecules is a critical initial step.
Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises
Authors: Alghamdi Faisal A. , Al-Kasim Fawaz , Alshhada Forat , Ghareeb Eatedal , Azmet Fauzia R. , Almudaibigh Adel , Baitalmal Lobna , Alnawfal Bedah , Alluqmani Rehab 
Published: March 2024

AbstractSickle cell anemia (SCA) is a globally prevalent inherited condition, with acute chest syndrome (ACS) being one of its most severe complications. ACS frequently leads to hospitalization, requires intensive care unit (ICU) admission, and can even result in death. This study aimed to discern the early indicators of impending ACS in children with SCA who were initially hospitalized due to painful vaso-occlusive crises (VOC). This was a retrospective, case‒control investigation of 120 patients aged 1–14 years seen at the King Saud Medical City in Riyadh, Saudi Arabia from January 2021 to December 2022. Patients were classified into cases and controls: those who developed and did not develop ACS during hospital stay, respectively. Demographic factors, laboratory results, vital and clinical signs, and treatment protocols were compared between these groups. The following were significant predictors of impending ACS: previous diagnosis of asthma, history of ACS, recent upper respiratory tract symptoms prior to admission, and need for a blood transfusion within the first 24 h of admission due to a drop in hemoglobin levels. Further regression analysis indicated that elevated steady-state mean corpuscular volume, leukocyte count, total bilirubin, and an increased absolute neutrophil count level 24 h after admission also foreshadowed impending ACS among patients admitted for VOC. The location of pain was also significant; the incidence of ACS was higher in patients with back pain, but lower in those with pain confined to the limbs. The ACS group had a longer average duration of hospital stay compared to those with VOC alone, (7.6 vs. 5.8 days). Among patients initially admitted for VOC, 15.7% were diagnosed with ACS. Most ACS cases were managed with transfusions and antibiotics, and nearly one-third of patients needed admission to an ICU or a high-dependency area.
Cathodoluminescence differentiates sedimentary organic matter types
Authors: Hackley Paul C. , McAleer Ryan J. , Jubb Aaron M. , Valentine Brett J. , Birdwell Justin E. 
Published: March 2024

AbstractHigh-resolution scanning electron microscopy (SEM) visualization of sedimentary organic matter is widely utilized in the geosciences for evaluating microscale rock properties relevant to depositional environment, diagenesis, and the processes of fluid generation, transport, and storage. However, despite thousands of studies which have incorporated SEM methods, the inability of SEM to differentiate sedimentary organic matter types has hampered the pace of scientific advancement. In this study, we show that SEM-cathodoluminescence (CL) properties can be used to identify and characterize sedimentary organic matter at low thermal maturity conditions. Eleven varied mudstone samples with a broad array of sedimentary organic matter types, ranging from the Paleoproterozoic to Eocene in age, were investigated. Sedimentary organic matter fluorescence intensity and CL intensity showed an almost one-to-one correspondence, with certain exceptions in three samples potentially related to radiolytic alteration. Therefore, because CL emission can be used as a proxy for fluorescence emission from sedimentary organic matter, CL emission during SEM visualization can be used to differentiate fluorescent from non-fluorescent sedimentary organic matter. This result will allow CL to be used as a visual means to quickly differentiate sedimentary organic matter types without employing correlative optical microscopy and could be widely and rapidly adapted for SEM-based studies in the geosciences.
Hierarchical organization of human physical activity
Authors: Búzás András , Makai András , Groma Géza I. , Dancsházy Zsolt , Szendi István , Kish Laszlo B. , Santa-Maria Ana Raquel , Dér András 
Published: March 2024

AbstractHuman physical activity (HPA), a fundamental physiological signal characteristic of bodily motion is of rapidly growing interest in multidisciplinary research. Here we report the existence of hitherto unidentified hierarchical levels in the temporal organization of HPA on the ultradian scale: on the minute's scale, passive periods are followed by activity bursts of similar intensity (‘quanta’) that are organized into superstructures on the hours- and on the daily scale. The time course of HPA can be considered a stochastic, quasi-binary process, where quanta, assigned to task-oriented actions are organized into work packages on higher levels of hierarchy. In order to grasp the essence of this complex dynamic behaviour, we established a stochastic mathematical model which could reproduce the main statistical features of real activity time series. The results are expected to provide important data for developing novel behavioural models and advancing the diagnostics of neurological or psychiatric diseases.
Laser assisted pulmonary metastasectomy promises a low local recurrence rate
Authors: Shalabi Ahmad , Ehab Ahmed , Shalabi Sundus F. , Kugler Gudrun , Schäfers H.-J. , Graeter Thomas 
Published: March 2024

AbstractPulmonary metastasectomy (PM) is consensually performed in a parenchyma-sparing manner to preserve functionally healthy lung tissue. However, this may increase the risk of local recurrence at the surgical margin. Laser assisted pulmonary metastasectomy (LPM) is a relatively recent innovation that is especially useful to resect multiple metastatic pulmonary nodules. In this study we investigated the rate of local recurrence after LPM and evaluated the influence of various clinical and pathological factors on local recurrence. Retrospectively, a total of 280 metastatic nodules with different histopathological entities were studied LPM from 2010 till 2018. All nodules were resected via diode-pumped neodymium: yttrium–aluminum-garnet (Nd:YAG) 1,318 nm laser maintaining a safety margin of 5 mm. Patients included were observed on average for 44 ± 17 months postoperatively. Local recurrence at the surgical margin following LPM was found in 9 nodules out of 280 nodules (3.21%). Local recurrence at the surgical margin occurred after 20 ± 8.5 months post operation. Incomplete resection (p =  < 0.01) and size of the nodule (p = < 0.01) were associated with significantly increased risk of local recurrence at the surgical margin. Histology of the primary disease showed no impact on local recurrence. Three and five-year survival rates were 84% and 49% respectively. Following LPM, the rate of local recurrence is low. This is influenced by the size of the metastatic nodules and completeness of the resection. Obtaining a safety margin of 5 mm seems to be sufficient, larger nodules require larger safety margins.
Photoredox-Catalyzed Oxidative C–H Alkylation of Glycine Derivatives with 4-Alkyl-1,4-dihydropyridines
Authors: Babu Madala Hari , Jang Eunbin , Sim Jaehoon , Jang Hyesu , Kim Sang Kyum 
Published: March 2024

AbstractOxidative α-C(sp3)–H alkylation of N-arylated glycine derivatives with 4-alkyldihydropyridine derivatives (alkyl-DHPs) as versatile alkyl radical precursors has been developed. Utilizing visible-light-driven photoredox catalysis and ammonium persulfate as an oxidizing agent, this methodology facilitates the site-selective alkylation of glycine derivatives, enabling the site-selective alkylation of peptides. The reaction exhibits broad substrate scope, including various alkyl radicals and acid-labile functional groups. This approach expands the synthetic toolbox in peptide chemistry, offering a mild and efficient method for the synthesis of modified peptides.
Promoting Planetary Health at Regional Level: A Qualitative Analysis of a Multisectoral Health and Environment Program
Authors: Siltanen U. , Prass M. , Puhakka R. , Lehtimäki J. , Haveri H. 
Published: March 2024

Abstract
The central idea of planetary health is a strong interdependency between human health and the environment. Thus far, practical initiatives often focus on a few narrow sectors at a time. We are lacking knowledge on the efficacy of broader interorganizational collaborations at the city or regional level.
Nature Step to Health – Lahti Regional Health and Environment Programme 2022–2032 in Finland is a planetary health program. It provides a practical example of regional collaboration between various organizations such as public healthcare, municipalities, and educational and research organizations in order to achieve tangible results in striving for more sustainable futures. The program facilitates collaboration and communicates to actors that can initiate projects and implement planetary health in their everyday work. This case study aims to find out how the program has succeeded in coordinating initiatives that could support different organizations to enhance sustainability and planetary health.
We conducted six semi-structured interviews about the experiences of practical actors participating in projects that relate to Nature Step to Health. The goal was to find out strengths as well as potential challenges or barriers in implementing planetary health in their organizations. The participants were generally positive about the measures, collaboration, and networking. The organization’s comprehensive approach to health promotion was considered a strength. Challenges raised by the participants were related to the difficulty to uptake the concept of combining health and sustainability in their work. There were also shortcomings in, for example, communication of the project, and lack of time and expertise.

Information
© The Authors 2024
Convergence of non-linear diagonal frame filtering for regularizing inverse problems
Authors: Ebner Andrea , Haltmeier Markus 
Published: March 2024

Abstract
Inverse problems are key issues in several scientific areas, including signal processing and medical imaging. Since inverse problems typically suffer from instability with respect to data perturbations, a variety of regularization techniques have been proposed. In particular, the use of filtered diagonal frame decompositions (DFDs) has proven to be effective and computationally efficient. However, existing convergence analysis applies only to linear filters and a few non-linear filters such as soft thresholding. In this paper, we analyze filtered DFDs with general non-linear filters. In particular, our results generalize singular value decomposition-based spectral filtering from linear to non-linear filters as a special case. As a first approach, we establish a connection between non-linear diagonal frame filtering and variational regularization, allowing us to use results from variational regularization to derive the convergence of non-linear spectral filtering. In the second approach, as our main theoretical results, we relax the assumptions involved in the variational case while still deriving convergence. Furthermore, we discuss connections between non-linear filtering and plug-and-play regularization and explore potential benefits of this relationship.
Relating permeability and electrical conductivity in partially saturated porous media by means of the Johnson–Koplik–Schwartz characteristic length
Authors: Duy Thanh Luong , Jougnot Damien , Solazzi Santiago G , Luo Haoliang , Hung Nguyen Manh , Van Nghia Nguyen , Van Do Phan , Huong Luong Thi Thanh 
Published: March 2024

SUMMARY
In this work, we revisit the seminal concept of Johnson–Koplik–Schwartz (JKS) length Λ, that is a characteristic length representing an effective pore size which controls various transport-related properties of porous media, such as, the permeability and the electrical conductivity. We present a novel closed-form equation that predicts the behaviour of Λ in partially saturated media, for different saturation states. Using previous models in the literature that predict the intrinsic and relative electrical conductivities under partially saturated conditions, we infer the JKS length Λ and the electrical formation factor F as functions of water saturation and properties associated with the pore-size distribution of the probed porous medium. The proposed method permits to estimate the effective permeability and the relative permeability directly from electrical conductivity measurements, thus opening new-avenues for the remote characterization of partially saturated media. We believe that this new model will prove useful for various characterization and modelling applications from reservoir (CO2 or hydrogen storage) to vadose zone studies.
Healthy lifestyle interventions within the curriculum in school-age children: systematic review and meta-analysis
Authors: Balderas-Arteaga Nydia , Mendez Kenia , Gonzalez-Rocha Alejandra , Pacheco-Miranda Selene , Bonvecchio Anabelle , Denova-Gutiérrez Edgar 
Published: March 2024

Abstract
Childhood obesity is a major public health challenge. Previous research has identified the impact of school-based interventions for preventing and treating obesity; we hypothesized that when curricular changes are integrated, results could be exponentiated. This study aimed to systematically review and conduct a meta-analysis of the published literature analyzing information about school-based interventions inserted in the curriculum. The Cochrane Handbook methodology was followed. An electronic search was conducted in five databases, with a specific design strategy per database. Randomized controlled trials or quasi-experimental studies of children with nutrition and physical activity (PA) interventions inserted into the school curricula were included. The risk of bias was assessed with the Risk of Bias tool. The mean differences were pooled using a fixed-effects model for the meta-analysis. The certainty of the evidence was evaluated according to the guidelines of the Grading of the Recommendations, Assessment, Development, and Evaluations working group (Protocol ID: CRD42021270557). After the screening and selection process, 12 studies were included. The interventions identified, based on the school curricula, include classroom activities and homework, among others. A meta-analysis with five intervention groups presented an overall mean difference of −0.14 body mass index (BMI) Z-score (95% CI: −0.25, −0.03) after this intervention with high certainty of the evidence. This systematic review and meta-analysis suggest that nutrition and PA lessons inserted into the curricula and supported with additional activities (i.e. homework, workshops, etc.) could increase nutrition knowledge and improve attitudes toward fruit, vegetables, and water consumption, and BMI Z-score reduction.
In vitro and in silico analysis unravelled clinically desirable attributes of Bacillus altitudinis L-asparaginase
Authors: Lailaja V P , Hari Vishnu , Sumithra T G , Anusree V N , Suresh Gayathri , Sanil N K , Sharma S.R Krupesha , Gopalakrishnan A 
Published: March 2024

Abstract

Aims
To identify a marine L-asparaginase with clinically desirable attributes and characterize the shortlisted candidate through in silico tools

Methods and results
Marine bacterial strains (number = 105) isolated from marine crabs were evaluated through a stepwise strategy incorporating the crucial attributes for therapeutic safety. The results demonstrated the potential of eight bacterial species for extracellular L-asparaginase production. However, only one isolate (Bacillus altitudinis CMFRI/Bal-2) showed clinically desirable attributes, viz. extracellular production, type-II nature, lack of concurrent L-glutaminase and urease activities, and presence of ansZ (functional gene for clinical type). The enzyme production was 22.55 ± 0.5 µM/mg protein/min within 24 h without optimization. The enzyme also showed good activity and stability in pH 7–8 and temperature 37°C, predicting the functioning inside the human body. The Michealis-Menten constant (Km) was 14.75 µM. Detailed in silico analysis based on functional gene authenticating the results of in vitro characterization and predicted the nonallergenic characteristic of the candidate. Docking results proved the higher affinity of the shortlisted candidate to L-asparagine than L-glutamine and urea.

Conclusion
Comprehensively, the study highlighted B. altitudinis type II asparaginase as a competent candidate for further research on clinically safe asparaginases.
Tectonic and Crustal Processes Drive Multi-Million Year Arc Magma Evolution Leading up to Porphyry Copper Deposit Formation in Central Chile
Authors: Large Simon J E , Nathwani Chetan L , Wilkinson Jamie J , Knott Thomas R , Tapster Simon R , Buret Yannick 
Published: March 2024

Abstract
Subduction zone magmatism is a major control of volcanism, the generation of modern continental crust and the formation of economically important porphyry Cu–(Mo–Au) deposits. Reading the magmatic record of individual arc segments and constraining the rates of magmatic changes are critical in order to fully understand and quantify the processes that drive magma evolution in subduction settings during arc growth. This study focuses on the San Francisco Batholith and the Rio Blanco-Los Bronces porphyry deposit cluster in central Chile, which provides an igneous rock record over ~13.5 Myr of arc evolution. We use whole-rock geochemistry, zircon geochronology and Hf isotope geochemistry to track changes in the crustal magmatic system of this arc segment during crustal thickening and porphyry Cu deposit formation. By combining the analytical dataset with Monte Carlo fractional crystallisation and assimilation fractional crystallisation modelling, we test a model for significant crustal involvement during magma evolution. Systematic and continuous increases in Dy/Yb, La/Yb, V/Sc and Sr/Y in the magmas over time indicate a transition in the main fractionation assemblage from plagioclase-dominated to amphibole-dominated that reflects deeper crystallisation and/or a higher meltwater content. Concomitant decreases in εHf and Th/La as well as increasing Ba/Th are best explained by assimilation of progressively deeper crustal lithologies from low (Chilenia) to high Ba/Th (Cuyania) basement terranes. Our study highlights that an increasingly hydrous magma and a deepening locus of crustal magma differentiation and assimilation, driven by crustal thickening contemporaneous with increased tectonic convergence and ingression of the aseismic Juan Fernandez ridge, can account for all investigated aspects of the multi-Myr magmatic evolution leading up to the formation of the Rio Blanco-Los Bronces porphyry Cu deposits. Our findings corroborate the importance of high-pressure differentiation of hydrous magma for the formation of Andean-style porphyry deposits. Once magmas favourable for porphyry Cu mineralisation were generated in the lower crust, multiple episodes of efficient magma migration into the upper crust fed several, discrete, shallow magmatic-hydrothermal systems over ~3.5 Myr to form the world’s largest known Cu resource at Rio Blanco-Los Bronces.
Depth of technological capability: a new approach to the technological development of latecomer oil service companies
Authors: Tarighi Sina 
Published: March 2024

Purpose
The purpose of this study is to define and develop a new technological development path for latecomer firms in developing countries.

Design/methodology/approach
An analytical framework for development based on the technological capability (TC) dimensions is developed and examined in the drilling sector. Since the process of TC accumulation is dynamic, the case study approach is the best method for an exploratory theory-building study. Through a comparative case study of two Iranian drilling contractors, a new path for the technological development of latecomer oil service companies is proposed.

Findings
The study of two cases indicates that despite having similar scope and levels of TC, one of them demonstrated superior technical performance. To address this difference, the concept of operational efficiency is introduced which is considered the outcome of increasing the depth of TC.

Practical implications
Although upgrading the level of technological and innovation capability is an important path for technological development, latecomers that suffer from various disadvantages can perform their routine activities with superior performance and develop through their basic operational/production capabilities. Also, specialized indicators designed for assessing the level and depth of TC in the drilling industry have important insights for evaluating the technological and competitive position of oil service companies.

Originality/value
To the best of the author’s knowledge, this study takes the first step in defining and elaborating on the concept of depth of TC as a development path for latecomers. It also introduced a novel approach to the global operational/production efficiency frontier as a target for their catch-up.