bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of JAK2V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera
Authors: Ganly Peter , Hanrahan Vickie , Baker Bart , Romeril Ken 
Published: August 2006

AbstractOne hundred and forty four patients with a clinical indication of suspected polycythemia vera (PV), essential thrombocythemia, or idiopathic myelofibrosis were screened for JAK2V617F and the mutation frequency was 47, 51, and 50%, respectively. Previous investigations enabled 42 of 66 patients with suspected PV to be definitively diagnosed either as PV according to WHO criteria or to have this diagnosis excluded. Ninety‐six percent of those with PV were JAK2V617F, whereas all patients without PV did not have the mutation. Early screening of suspected PV patients for JAK2V617F rapidly identifies nearly all those with PV without invasive or less specific conventional investigations. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
Posttraumatic stress disorder in children affected by sickle‐cell disease and their parents
Authors: Hofmann Michel , de Montalembert Mariane , Beauquier‐Maccotta Bérengère , de Villartay Philippe , Golse Bernard 
Published: August 2006

AbstractChildren affected with sickle‐cell disease experience painful crises that may be life threatening, or felt as if they were. We evaluated by semistructured interviews and questionnaires the presence of posttraumatic stress disorder in 11 children affected by sickle‐cell disease and having suffered at least one hospitalization for a painful crisis, and in their parents (10 mothers, 1 father). Three children (27%) and four parents (40%) were diagnosed with the disorder. It was not correlated to the disease severity but, in parents, to a feeling of powerlessness over the child's illness (P = 0.04). Am. J. Hematol., 2006, © 2006 Wiley‐Liss, Inc.
Makrocyclisierung durch Ringschlussmetathese bei der Totalsynthese von Naturstoffen: Reaktionsbedingungen und Grenzen
Authors: Gradillas Ana , Pérez‐Castells Javier 
Published: August 2006

AbstractDer Aufbau von Makrocyclen durch Ringschlussmetathese (RCM) ist oft eine Schlüsselstufe bei der Synthese von Naturstoffen mit großen Ringen. Diese Reaktion bietet sich an wegen ihrer hohen Toleranz für funktionelle Gruppen sowie der Möglichkeit zu nachfolgenden Umwandlungen. Dabei ist die Wahl geeigneter Reaktionsbedingungen für den Erfolg der Synthese entscheidend. Im folgenden Aufsatz fassen wir Arbeiten zusammen, die sich mit der Entwicklung effizienter RCM‐Reaktionen im Rahmen der Totalsynthese makrocyclischer Naturstoffe befassen. Dies soll helfen, bei zukünftigen Synthesen die zeitraubende Phase der Optimierung der Reaktionsbedingungen zu reduzieren.
A Posterior Tale
Authors: Korn Edward L. , Freidlin Boris 
Published: August 2006

AbstractA vignette is presented that naively suggests that the posterior distribution of a parameter may not always contain everything that is needed for inference about that parameter. The resolution of this apparent paradox is discussed as well as its relation to real‐life problems involving data monitoring of clinical trials. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modelling Forest Dynamics: A Perspective from Point Process Methods
Authors: Comas Carlos , Mateu Jorge 
Published: August 2006

AbstractThis paper reviews the main applications of (marked) point process theory in forestry including functions to analyse spatial variability and the main (marked) point process models. Although correlation functions do describe spatial variability at distinct range of scale, they are clearly restricted to the analysis of few dominant species since they are based on pairwise analysis. This has over‐simplified the spatial analysis of complex forest dynamics involving “large” number of species. Moreover, although process models can reproduce, to some extent, real forest spatial patterns of trees, the biological forest‐ecological interpretation of the resulting spatial structures is difficult since these models usually lack of biological realism. This problem gains in strength as usually most of these point process models are defined in terms of purely spatial relationships, though in real life, forest develop through time.We thus aim to discuss the applicability of such formulations to analyse and simulate “real” forest dynamics and unwrap their shortcomes. We present a unified approach of modern spatially explicit forest growth models. Finally, we focus on a continuous space‐time stochastic process as an alternative approach to generate marked point patterns evolving through space and time. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Staurosporine induces tyrosine phosphorylation in Dictyostelium discoideum proteins
Authors: Andrioli Luiz Paulo , Souza Glaucia Mendes , da Silva Aline Maria 
Published: August 2006

AbstractThe treatment of cells with staurosporine results in inhibition and less frequently activation of protein kinases, in a cell‐type specific manner. In the social amoeba Dictyostelium discoideum, staurosporine induces marked changes in cell morphology affecting growth and development. Here we describe that incubation of D. discoideum growing or starved cells with staurosporine results in a rapid and unexpected tyrosine phosphorylation on two polypeptides of ∼64 and ∼62 kDa. These proteins emerge as novel substrates for tyrosine phosphorylation opening up new perspectives for the study of cell signalling in D. discoideum. Copyright © 2006 John Wiley & Sons, Ltd.
Characterization of Peroxide‐Bound Heme Species Generated in the Reaction of Thermally Tolerant Cytochrome c552 with Hydrogen Peroxide
Authors: Ichikawa Yusuke , Nakajima Hiroshi , Watanabe Yoshihito 
Published: August 2006

AbstractPeroxide‐bound heme species have been considered difficult to detect under physiological conditions because of their intrinsically transient properties. Cytochrome c552 (cyt c552), from Thermus thermophirus HB8, bearing a mutation to an alanine at Met69 (M69A) reacts with hydrogen peroxide (H2O2) to generate a detectable hydroperoxo‐ferric heme ([Fe3+OOH]) species at ambient temperature. EPR measurements during appropriate reaction periods reveal that the [Fe3+OOH] species is in a preequilibrium state between the resting form of the cyt c552 variant and a subsequent intermediate, compound II with a protein radical. Addition of ascorbic acid to the reaction mixture of the cyt c552 variant and H2O2 does not affect the formation of the [Fe3+OOH] species,a result suggesting that the species is incompetent for the oxidation of even an oxidatively fragile substrate such as ascorbic acid. Another variant bearing an additional mutation to aspartic acid at Val49 (V49D/M69A) reveals that a highly hydrophobic heme cavity in cyt c552 accounts for the generation of the durable [Fe3+OOH] species. The less polar environment inside the cavity is expected to prevent H2O from approaching the cavity. This would suppress protonation of the distal oxygen atom of the [Fe3+OOH] species and retard subsequent dissociation of H2O from the OOH moiety.
The Consequences of Lysosomotropism on the Design of Selective Cathepsin K Inhibitors
Authors: Black W. Cameron , Percival M. David 
Published: August 2006

AbstractMany drug candidates contain a basic functional group that results in lysosomotropism—the accumulation of drug in the acidic lysosomes of a cell. When evaluating inhibitors of lysosomal enzymes, such as the cathepsins, this physical property can have a dramatic impact on the functional selectivity of the test compounds. A basic P3 substituent in cathepsin K inhibitors provides a means of achieving potent and selective enzyme inhibition. To evaluate the whole‐cell selectivity of the basic cathepsin K inhibitor L‐006235, we identified the irreversible pan‐selective cathepsin probe BIL‐DMK and used it to design whole‐cell enzyme‐occupancy assays. These cell‐based assays showed a dramatic reduction in selectivity against cathepsins B, L, and S relative to the selectivities observed in enzyme assays. Two‐photon confocal fluorescence microscopy showed punctated subcellular localization of L‐006235, which colocalized with BODIPY‐labelled Lysotracker, consistent with compound lysosomotropism. To address this potential problem, a series of potent cathepsin K inhibitors was developed by replacing the P2P3 amide bond with a metabolically stable trifluoroethylamine moiety. X‐ray crystallography has identified the binding of this functional group to active‐site residues in cathepsin K. This modification resulted in increased potency and selectivity that allowed the removal of the basic P3 substituent. The resulting nonbasic inhibitor L‐873724 is a 0.2 nMinhibitor of cathepsin K with cathepsin B, L, and S potencies that were not shifted between purified enzyme and whole‐cell assays; thus indicating that this compound is not lysosomotropic. L‐873724 exhibits excellent pharmacokinetics and is orally active in a monkey model of osteoporosis at 3 mg kg−1q.d.
A multifaceted approach to the treatment of phantom limb pain using hypnosis
Authors: Bamford Candy 
Published: August 2006

AbstractThis study looks at the efficacy of a multifaceted approach to the relief of phantom limb pain. Using hypnosis, four therapeutic interventions are incorporated into this treatment: hypnotic analgesia; visualization and movement of an imaginary limb to facilitate the movement of the phantom limb; psychological therapy and self‐hypnosis. Twenty‐five amputees completed a course of hypnosis averaging six weekly sessions. All patients were taught self‐hypnosis and encouraged to continue this practice on a daily basis. The levels, duration and frequency of all pains were recorded before and after each session with a follow‐up postal questionnaire sent out six months after treatments were completed. Results showed a highly significant (p < 0.001) reduction in pain levels from baseline to post treatment. Pain levels showed some increase by the six month follow‐up questionnaire but were still significantly lower than the baseline. This study supports these combined hypnotic techniques as a treatment for phantom limb pain. Copyright © 2006 British Society of Experimental & Clinical Hypnosis. Published by John Wiley & Sons, Ltd.
A qualitative study of the experience of self‐hypnosis or Johrei in metastatic breast cancer using interpretative phenomenological analysis
Authors: Bennett Bryan M. , Laidlaw Tannis M. , Dwivedi Prabudha , Naito Akira , Gruzelier John H. 
Published: August 2006

AbstractIn this paper we explore the meaning and experience of living with breast cancer that had returned after conventional treatment. We focus on the process of learning and applying a specific psychological intervention to aid with the coping process. Of sixteen women who were randomized to self‐hypnosis training, Johrei training or a control wait‐list group, eight agreed to be interviewed. Interviews were recorded, transcribed and then analysed using interpretative phenomenological analysis. The major themes that conceptualized living with the return of breast cancer were self‐identity, self‐blame, social isolation and feelings of being constrained. The themes relating to psychological intervention were gaining a sense of control and empowerment, normalizing and re‐attribution, and a powerful military metaphor for dealing with the actual cancer. Copyright © 2006 British Society of Experimental & Clinical Hypnosis. Published by John Wiley & Sons, Ltd.
Pseudopolymorphism of Aliphatic Amine/4‐tert‐Butylcalix[4]arene Inclusion Compounds: Supramolecular Stabilization as a Route to Polar Clusters and Layers
Authors: Brown Philip O. , Udachin Konstantin A. , Enright Gary D. , Ripmeester John A. 
Published: August 2006

Abstract4‐tert‐Butylcalix[4]arene (4tBC4A) is a versatile host capable of forming a variety of 1:1 and 2:1 inclusion compounds typically stabilized through van der Waals interactions. Preliminary studies in our group have demonstrated that inclusion of n‐butylamine in 4tBC4A results in a series of pseudopolymorphic inclusion compounds, including a new 3:1 inclusion motif. Using a combination of SCXRD, TGA, solid state NMR, and PXRD, we now elaborate upon the relationship between these pseudopolymorphs. We also demonstrate that larger amines demonstrate a similar degree of pseudopolymorphism, allowing for the production of customized materials using self‐assembly guided by competing weak forces. Finally, we comment on the structural implications of the relative dominance such forces in the formation of calixarene‐based supramolecular frameworks.
Diastereoselective Multicomponent Cyclizations of Fischer Carbene Complexes, Lithium Enolates, and Allylmagnesium Bromide Leading to Highly Substituted Five‐ and Six‐Membered Carbocycles
Authors: Barluenga José , Pérez‐Sánchez Iván , Suero Marcos G. , Rubio Eduardo , Flórez Josefa 
Published: August 2006

AbstractThe one‐pot sequential reaction of a chromium alkoxycarbene complex, a ketone or ester lithium enolate, and allylmagnesium bromide enabled the selective synthesis of novel diastereomerically pure pentasubstituted cyclopentanols or tetrasubstituted 1,4‐cyclohexanediols, depending on the degree of substitution at the Cβ position of the enolate anion. A few exceptions have been encountered in which tetrasubstituted cyclopentanols or pentasubstituted 1,4‐cyclohexanediols were selectively formed. The use of 2‐iodoethoxycarbene complexes gave access to 1,2,4‐cyclohexanetriols. These multicomponent‐coupling reactions involved the formation of lithium alkylpentacarbonylchromates as key intermediates, which further evolved through intramolecular processes, such as insertion of an alkene, CO insertion or addition to a carbonyl group, and, moreover, could be trapped in intermolecular reactions with different electrophiles and styrene. The substitution pattern of the alkylchromate carbon chain has been proposed to control the nature of the annulation process.
Crystal Structures and Magnetic Properties of Alkali‐Metal Lanthanide Oxides A2LnO3 (A: Li, Na; Ln: Ce, Pr, Tb).
Authors: Hinatsu Yukio , Doi Yoshihiro 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Colloidal Upconverting NaYF4 Nanocrystals Doped with Er3+, Yb3+ and Tm3+, Yb3+ via Thermal Decomposition of Lanthanide Trifluoroacetate Precursors.
Authors: Boyer John‐Christopher , Vetrone Fiorenzo , Cuccia Louis A. , Capobianco John A. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Red Emitting Phosphors Based on Rare Earth Oxycarbonates.
Authors: Mayama Yuhei , Koyabu Kazuhiko , Masui Toshiyuki , Tamura Shinji , Imanaka Nobuhito 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Plasma Processing Approach to Molecular Surface Tailoring of Nanoparticles: Improved Photocatalytic Activity of TiO2.
Authors: Cho Jai , Denes Ferencz S. , Timmons Richard B. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Characterization and Structural Determination of a New Sodium Lanthanum Phosphate Thiosulfate, Na2La[PO4][S2O3].
Authors: Zhizhin Mikhail , Pounds Hillary A. , Spiridonov Felix M. , Komissarova Lydia N. , Dorhout Peter K. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cluster‐Type Basic Lanthanide Iodides [Ln6(μ6‐O)(μ3‐OH)8 (H2O)24]I8(H2O)8 (Ln: Nd, Eu, Tb, Dy).
Authors: Mudring Anja‐Verena , Timofte Tudor , Babai Arash 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Li9Nd2[PS4]5: A New Lithium Lanthanoid(III) Thiophosphate(V).
Authors: Komm Theresa , Schleid Thomas 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cs2Gd6N2Te7: The First Quaternary Nitride Telluride of the Lanthanides.
Authors: Lissner Falk , Schleid Thomas 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electrochemical Single Crystal Growth of Tb24O44 Microparticles.
Authors: Isota Shinya , Masui Toshiyuki , Tamura Shinji , Imanaka Nobuhito 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
β‐Homoamino Acids as Catalysts in Enantioselective Intra‐ and Intermolecular Aldol Reactions.
Authors: Limbach Michael 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Intramolecular Arylation of Aldehydes Promoted by Reaction with IPy2BF4/HBF4: Synthesis of Benzocyclic Ketones.
Authors: Barluenga Jose , Trincado Monica , Rubio Eduardo , Gonzalez Jose M. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed Coupling Reaction of 3‐Bromo Benzo[b]furan, ‐thiophene and ‐selenophene 2‐Carboxaldehyde. Preparation of Tetracyclic Heteroaromatic Derivatives.
Authors: Kirsch Gilbert , Deprets Stephanie 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalyst‐Free Oxidation of Alcohols at Room Temperature Using Water as Solvent.
Authors: Lei Ziqiang , Yang Yaoxia , Bai Xiangzhen 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amino Alcohols as Ligands for Nickel‐Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides with Arylboronic Acids.
Authors: Gonzalez‐Bobes Francisco , Fu Gregory C. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heck Coupling with Nonactivated Alkenyl Tosylates and Phosphates: Examples of Effective 1,2‐Migrations of the Alkenyl Palladium(II) Intermediates.
Authors: Hansen Anders L. , Ebran Jean‐Philippe , Ahlquist Marten , Norrby Per‐Ola , Skrydstrup Troels 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Synthesis of Esters and Amides from Unprotected Hydroxyaromatic and ‐aliphatic Carboxylic Acids.
Authors: Katritzky Alan R. , Singh Sanjay K. , Cai Chunming , Bobrov Sergey 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective Oxidation of Oximes to Carbonyl Compounds Using N‐Bromo‐N‐benzoyl‐4‐toluenesulfonamide.
Authors: Khazaei Ardeshir , Manesh Abbas Amini 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
tert‐Butyl Ethers: Renaissance of an Alcohol Protecting Group. Facile Cleavage with Cerium(III) Chloride/Sodium Iodide.
Authors: Bartoli Giuseppe , Bosco Marcella , Carlone Armando , Locatelli Manuela , Marcantoni Enrico , Melchiorre Paolo , Sambri Letizia 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Na2S2O4‐Promoted Radical Addition Reaction of Perfluoroalkyl Iodides with Allenes and the Pd(0)‐Catalyzed Stereoselective Sonogashira Coupling Reaction of Addition Products with Propargyl Alcohol.
Authors: Ma Shengming , Ma Zhichao 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Diastereoselective Silyl‐Modified Sakurai Multicomponent Reaction.
Authors: Pospisil Jioi , Kumamoto Takuya , Marko Istvan E. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rearrangement of Homoallylic Alcohols Induced by DAST.
Authors: Canova Sophie , Bellosta Veronique , Mignani Serge , Bigot Antony , Cossy Janine 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Study of Amidocarbonylation Reactions Catalyzed by Pd/HZSM‐5.
Authors: Yang Ke Wu , Jiang Xuan Zhen 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
1,2‐Bis(diphenylphosphino)carborane as a Dual Mode Ligand for Both the Sonogashira Coupling and Hydride‐Transfer Steps in Palladium‐Catalyzed One‐Pot Synthesis of Allenes from Aryl Iodides.
Authors: Nakamura Hiroyuki , Kamakura Takaya , Onagi Shinya 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Free‐Radical Version of the Strecker Synthesis of α‐Aminoamides Promoted by Aqueous H2O2/TiCl3/HCONH2 System.
Authors: Cannella Rosalba , Clerici Angelo , Panzeri Walter , Pastori Nadia , Punta Carlo , Porta Ombretta 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold‐Catalyzed Intermolecular Hydroamination of Allenes with Arylamines and Resulting High Chirality Transfer.
Authors: Nishina Naoko , Yamamoto Yoshinori 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.