bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Characterization of Water‐Soluble Zinc, Cobalt(II) and Copper(II) Complexes with a Neutral Tripodal N,N,N‐Ligand: Crystal Structures of [(κ3N‐4‐TIPOiPr)Co(H2O)(κ2O‐NO3)]NO3 and [(κ3N‐4‐TIPOiPr)Cu(H2O)(κO‐SO4)], 4‐TIPOiPr = tris(2‐isopropylimidazol‐4(5)‐yl)phosphane oxide
Authors: Kunz Peter C. , Zribi Alya , Frank Walter , Kläui Wolfgang 
Published: April 2007

AbstractThe development of ligands bearing substituents to model a hydrophobic enzyme cavity and concurrently showing sufficient solubility in aqueous media seems somehow paradox. The zinc and cobalt(II) nitrato (4, 5) and copper(II) sulfato (6) complexes of the new tris(2‐isopropylimidazol‐4(5)‐yl)phosphane oxide ligand (4‐TIPOiPr, 2a) show exactly these properties; in addition, the structure of the CoII complex 5·MeOH·Et2O shows striking similarity to the active site of CoII‐substituted carbonic anhydrase. 2a and its metal complexes are stable towards hydrolysis which is in contrast to the known sensitivity of (imidazol‐2‐yl)phosphane oxides.
(TlMes2)[BF4] – Ein Salz mit linearem (Mes‐Tl‐Mes)+‐Ion
Authors: Kuzu Istemi , Neumüller Bernhard 
Published: April 2007

Abstract(TlMes2)[BF4] – A Salt with the Linear Cation (Mes‐Tl‐Mes)+TlMes3 was reacted with [BF3(OEt2)] in Et2O at 20 °C to give (TlMes2)[BF4] (1). 1 was characterized by NMR techniques, IR spectroscopy as well as by an X‐ray structure determination. According to this, 1 is built‐up by ifinite chains of cations and anions along [001]. The linear cations are rotated 90° to each other along the chains due to the coordination of the [BF4]− ion.
Replacement of Trimethylamine in Trimethylamine‐trispentafluoroethyl‐borane. Structures of [(C2F5)3BNMe3], [NMe4][(C2F5)3BOH], and K[(C2F5)3BCH2(CO)C6H5]
Authors: Bernhardt Eduard , Brauer David J. , Köckerling Martin , Pawelke Gottfried 
Published: April 2007

AbstractTrimethylamine‐tris(pentafluoroethyl)borane [(C2F5)3BNMe3] (1) reacts at 190 °C with water under displacement of the trimethylamine ligand to yield the hydroxy‐tris(pentafluoroethyl)borate [(C2F5)3BOH]− (2). In tributylamine 1 reacts with alkynes HC≡CR to form novel ethynyl‐tris(pentafluoroethyl)borate anions [(C2F5)3BC≡CR]− – R = C6H5 (3), C6H4CH3 (4), Si(CH(CH3)2)3 (5) – in moderate yields. Compound 3 adds water across the triple bond to form the novel anion [(C2F5)3BCH2(CO)C6H5]− (6). The structures of [(C2F5)3BNMe3], [NMe4][(C2F5)3BOH] and K[(C2F5)3BCH2(CO)C6H5] have been determined by x‐ray crystallography.
Synthesis, Structure, and Properties of Iron(II) and Manganese(II) Bis[Tris(1‐Ethyl‐4‐Methylimidazolyl‐κN)Phosphine] Complexes
Authors: Malkhasian Aramice Y. S. , Nikolovski Borislava , Kucera Benjamin E. , Loloee Reza , Chavez Ferman A. 
Published: April 2007

AbstractFeIIL2(OTf)2 (1) and MnIIL2(OTf)2 (2) (L = tris(1‐ethyl‐4‐methylimidazolyl‐κN)phosphine; OTf= trifluoromethanesulfonate) were synthesized and their X‐ray structures were determined. Both complexes possess distorted octahedral geometry with high spin electron configuration at ambient temperature. Compound 1 exhibits a quasi‐reversible wave with E1/2 of 0.745 V versus Ag/AgNO3. Variable temperature magnetic measurements indicate that no spin‐crossover phenomenon for 1 is observed between 2.5 and 300 K. In addition, a plot of 1/χM versus T(K) is linear with a Curie constant of 3.48 emu mol−1 K.
Terminale und verbrückende Koordination von Indium‐Indium‐Bindungen – bemerkenswerte Polymorphie an der Verbindung In2R2[(OCC6H5)2CH]2 [R = C(SiMe3)3]
Authors: Uhl Werner , Lawerenz Andreas , Zemke Sarina 
Published: April 2007

AbstractTerminal and Bridging Coordination of Indium‐Indium Bonds – Remarkable Polymorphism with the Compound In2R2[(OCC6H5)2CH]2 [R = C(SiMe3)3]Treatment of the dimeric indium(II) subhalide (In2R2Cl2)2 (1) [R = C(SiMe3)3] with four equivalents of lithium dipivaloylmethanide or lithium dibenzoylmethanide afforded by the release of lithium chloride the corresponding diindium diacetylacetonates (2 and 3). The In‐In single bonds of the products were terminally coordinated by chelating acectylacetonato ligands and the bulky alkyl groups. Three different crystal structures were determined for the dibenzoylmethanide derivative 3 which in the solid state adopted trans and gauche conformations across the In‐In bonds. In contrast to the terminally arranged acetylacetonato ligands of compounds 2 and 3 alkylbenzoato ligands R‐COO− (3,5‐dimethylbenzoate and p‐tert‐butylbenzoate) gave the bridging coordination of the In‐In bonds by two chelating carboxylato groups (4 and 5). This particular coordination caused a strong shortening of the In‐In bond length in 4 compared to the unsupported bonds in 2 and 3 (264.6 versus 274.7 to 279.3 pm).
Synthese und Kristallstruktur des Fluorid‐ino‐Oxosilicats Cs2YFSi4O10
Authors: Schäfer Marion C. , Schleid Thomas 
Published: April 2007

AbstractSynthesis and Crystal Structure of the Fluoride ino‐Oxosilicate Cs2YFSi4O10The novel fluoride oxosilicate Cs2YFSi4O10 could be synthesized by the reaction of Y2O3, YF3 and SiO2 in the stoichiometric ratio 2 : 5 : 3 with an excess of CsF as fluxing agent in gastight sealed platinum ampoules within seventeen days at 700 °C. Single crystals of Cs2YFSi4O10 appear as colourless, transparent and water‐resistant needles. The characteristic building unit of Cs2YFSi4O10 (orthorhombic, Pnma (no. 62), a = 2239.75(9), b = 884.52(4), c = 1198.61(5) pm; Z = 8) comprises infinite tubular chains $\rm ^{1}_{\infty} \{[Si_{4}O_{10}]^{4-}\}$ of vertex‐condensed [SiO4]4− tetrahedra along [010] consisting of eight‐membered half‐open cube shaped silicate cages. The four crystallographically different Si4+ cations all reside in general sites 8d with Si–O distances from 157 to 165 pm. Because of the rigid structure of this oxosilicate chain the bridging Si–O–Si angles vary extremely between 128 and 167°. The crystallographically unique Y3+ cation (in general site 8d as well) is surrounded by four O2− and two F− anions (d(Y–O) = 221–225 pm, d(Y–F) = 222 pm). These slightly distorted trans‐[YO4F2]7− octahedra are linked via both apical F− anions by vertex‐sharing to infinite chains $\rm ^{1}_{\infty} \{[YO^{t}_{4/1}F^{v}_{2/2}]^{6-}\}$ along [010] (∢(Y–F–Y) = 169°, ∢(F–Y–F) = 177°). Each of these chains connects via terminal O2− anions to three neighbouring oxosilicate chains to build up a corner‐shared, three‐dimensional framework. The resulting hexagonal and octagonal channels along [010] are occupied by the four crystallographically different Cs+ cations being ten‐, twelve‐, thirteen‐ and fourteenfold coordinated by O2− and F− anions (viz.[(Cs1)O10]19−, [(Cs2)O10F2]21−, [(Cs3)O12F]24−, and [(Cs4)O12F2]25− with d(Cs–O) = 309–390 pm and d(Cs–F) = 360–371 pm, respectively).
Isolation and Structural Characterization of Di‐ and Tetra‐protonated Forms of the Macrocyclic Hexaamine trans‐6,13‐Dimethyl‐1,4,8‐11‐tetraazacyclodecane‐6,13‐diamine
Authors: Bernhardt Paul V. , Lawrance Geoffrey A. , Skelton Brian W. , White Allan H. 
Published: April 2007

AbstractCations derived by protonation of the ligand title compound (L1) have been structurally characterized in their di‐ and tetra‐ protonated forms in the salts [H2L1][ClO4]2·2H2O and [H4L1][ZnCl4]2·4H2O. In both structures, one half of the formula unit comprises the asymmetric unit of the structure, the macrocycle being centrosymmetric, with the two macrocycles adopting similar conformations. In both salts, a pair of diagonally opposed macrocyclic secondary amine groups are protonated; in the [H4L1]4+ salt, the additional pair of protons are accommodated on the exocyclic pendant amine groups. The dispositions of the pendent amines differ between the two structures, being ‘equatorial’ with respect to the macrocyclic ring in the [H2L1]2+ salt, and ‘axial’ in the [H4L1]4+ salt. In other structurally characterized compounds containing [H4L1]4+ the equatorial disposition was found in the ferricyanide adduct, while in the tetraperchlorate salt the axial disposition was identified. The differences in disposition of the exocyclic groups are ascribed to the extensive H‐bonding in the lattices.
Halogenido and Pseudohalogenido Complexes of (2,3,7,8,12,13,17,18‐Octaethyl‐5,15‐di‐p‐tolylcorrolato)manganese(IV)
Authors: Bröring Martin , Hell Christian , Steiner Melanie , Brandt Carsten D. 
Published: April 2007

AbstractA set of porphyrinoid manganese(IV) complexes with the 2,3,7,8,12,13,17,18‐octaethyl‐5,15‐di‐p‐tolylcorrolato ligand [(oedtc)MnIVX] (X = Cl, Br, I) was prepared by oxidation of a manganese(III) precursor. The most unexpected complex in this series, [(oedtc)MnIVI], was found to display significant thermal stability despite the unusual MnIV‐I bond and could be investigated by X‐ray diffraction. Attempted ligand exchange reactions of the chlorido derivative with the pseudohalide anions cyanide, azide, cyanate and thiocyanate yielded the desired [(oedtc)MnIVX] complex only as the isothiocyanate derivative while for the other species the reduction to manganese(III) was observed.
Metallkomplexe mit biologisch wichtigen Liganden. CLXVI Metallkomplexe mit Ferrocenylmethyl‐L‐cysteinat und 1,1′‐Ferrocenylbis‐(methyl‐L‐cysteinat) als Liganden
Authors: Freiesleben Doris , Hauck Thomas , Sünkel Karlheinz , Beck Wolfgang 
Published: April 2007

AbstractMetal Complexes of Biologically Important Ligands. CLXVI Metal Complexes with Ferrocenylmethylcysteinate and 1,1′‐Ferrocenylbis‐(methylcysteinate) as LigandsA series of complexes of transition metal ions ( Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+ ) and of lanthanide ions ( La3+, Nd3+, Gd3+, Dy3+, Lu3+ ) with the anions of ferrocenylmethyl‐L‐cysteine [(C5H5)Fe(C5H4CH(R)SCH2CH(NH3+)CO2−] (L1) and with the dianions of 1,1′‐ferrocenylbis(methyl‐L‐cysteine) [Fe(C5H4CH(R)SCH2CH(NH3+) CO2−)2] (R = H, Me, Ph) (L2) as N,O,S‐donors were prepared. With the monocysteine ferrocene derivative L1 as ligands complexes [MIIL12] or [CrIIIL12]Cl type complexes are formed whereas the bis(cysteine) ligand L2 yields insoluble complexes of type [ML2]n, presumably as coordination polymers. The magnetic moments of [MnIIL2]n, [PrIIIL2]n(OH)n and [DyIIIL2]n(OH)n exhibit “normal” paramagnetism.
Trivalent‐Intermediate Valent Cerium Ordering in CeRuSn – A Static Intermediate Valent Cerium Compound with a Superstructure of the CeCoAl Type
Authors: Riecken Jan F. , Hermes Wilfried , Chevalier Bernard , Hoffmann Rolf‐Dieter , Schappacher Falko M. , Pöttgen Rainer 
Published: April 2007

AbstractNew equiatomic stannide CeRuSn was synthesized from the elements by arc‐melting. CeRuSn was investigated by X‐ray powder and single crystal diffraction: C2/m, a = 1156.1(4), b = 475.9(2) and c = 1023.3(4) pm, β = 102.89(3)°, wR2 = 0.0466, 1229 F2 values and 38 variables. CeRuSn adopts a superstructure of the monoclinic CeCoAl type through a doubling of the subcell c axis. In the superstructure two crystallographically independent cerium sites occur. Based on the interatomic distances the two sites can be assigned to trivalent Ce2 and intermediate valent Ce1. This trivalent‐intermediate valent cerium ordering is underlined by magnetic susceptibility measurements χm(T): below 150 K χm, measured with decreasing temperature, follows a Curie‐Weiss law χm = Cm/(T–θp) giving Cm = 0.38 emuK/mol as Curie constant per CeRuSn mol; a value showing that only half of the cerium atoms are trivalent in CeRuSn (Cm = 0.807 emuK/mol for one free Ce3+ ion). A remarkable feature of the CeRuSn structure are the short Ce1–Ru1 (233 pm) and Ce1–Ru2 (246 pm) distances. The crystal chemistry of CeRuSn is discussed on the basis of a group‐subgroup scheme.
Copper(II) and Manganese(II) Coordination Polymers of 5‐Aminobenzene‐1,3‐dicarboxylic Acid (abdc) Ligand, Structural Studies of [Cu(μ4‐abdc) (DMF)]n and {[Mn(μ4‐abdc)(H2O)]·H2O}n
Authors: Xiao Hong‐Ping , Li Xin‐Hua , Morsali Ali , Wang Jia‐Guo , Zhang Wei‐Bing 
Published: April 2007

AbstractTwo new two‐dimensional CuII and MnII coordination polymers of 5‐aminobenzene‐1,3‐dicarboxylic acid (abdc) ligand, [Cu(μ4‐abdc)(DMF)]n and {[Mn(μ4‐abdc)(H2O)]·H2O}n, have been synthesized and characterized by elemental analysis and IR‐ spectroscopy. The single crystal X‐ray analyses show that the coordination number in these complexes is six, CuO5Cu and MnO5N. The compounds are structurally diverse and the coordination polymer obtained from copper show significant copper–copper interaction while the manganese coordination polymer shows Mn–Namino bond.
Potassium‐, Ammonium‐, Hydrazinium‐, Guanidinium‐, Aminoguanidinium‐, Diaminoguanidinium‐, Triaminoguanidinium‐ and Melaminiumnitroformate – Synthesis, Characterization and Energetic Properties
Authors: Göbel Michael , Klapötke Thomas M. 
Published: April 2007

AbstractEnergetic salts containing the nitroformate (trinitromethanide) anion with several nitrogen‐rich cations were investigated, including ammonium nitroformate (ANF), melaminium nitroformate (MNF), guanidinium nitroformate monohydrate (GNFH), aminoguanidinium nitroformate (AGNF), diaminoguanidinium nitroformate (DAGNF) as well as triaminoguanidinium nitroformate (TAGNF). All salts were characterized using vibrational spectroscopy (IR, Raman), mass spectrometry, multinuclear NMR spectroscopy and elemental analysis. The thermal decomposition of the salts was monitored using differential scanning calorimetry. In addition, the impact, friction and electrostatic sensitivity data were determined. Theoretical calculations were carried out in order to predict performance data such as detonation velocities and detonation pressures. The crystal structures of ANF, MNF, GNFH, AGNF, DAGNF and TAGNF were determined using single crystal X‐ray diffraction. In addition, a second polymorph of MNF was determined crystallographically as well as the crystal structures of MNF with methanol and MNF with dimethylsulfoxide. Finally, new polymorphs of potassium nitroformate (KNF) and hydrazinium nitroformate (HNF) were characterized using single crystal X‐ray diffraction.
Left Renal Vein Graft for Vascular Reconstruction in Abdominal Malignancy
Authors: Ohwada Susumu , Hamada Kunihiro , Kawate Susumu , Sunose Yutaka , Tomizawa Naoki , Yamada Tatsuya , Okabe Toshihiko , Ogawa Testushi , Sato Yoshihiro 
Published: April 2007

AbstractBackgroundAdvanced abdominal malignancies are occasionally invasive for the major blood vessels, such as the portal vein (PV), inferior vena cava (IVC), and major hepatic veins (HVs), and complete removal of the tumors is required for patients undergoing vascular resection and reconstruction. We used left renal vein (LRV) grafts for vascular reconstruction in patients with these malignancies and evaluated their clinical relevance.MethodsA total of 113 patients underwent vascular resection including the PV (42 patients), IVC (68 patients), and HV (3 patients) for hepatobiliary‐pancreatic or abdominal tumor resection. Of these, 11 patients underwent vascular reconstruction with a LRV graft of the PV, superior mesenteric vein (SMV), and HVs in 3 patients each, and the IVC in 2 patients. The HVs were resected with segmentectomy involving Couinaud’s segments VII, VIII, and IV; VII, VIII, and II; or III, IV, VIII in each patient. The PV and SMV were resected in 5 patients undergoing pancreaticoduodenectomy for pancreatic carcinoma, and in 1 patient being treated with extended right hepatectomy and pancreaticoduodenectomy for hepatic hilar carcinoma. The IVC was partially resected in 1 patient with advanced colon cancer and 1 with malignant schwannoma.ResultsThe mean graft length of LRV obtained was 3.6 (3.5–4.0) cm. The graft was used as a tube in 9 patients, and as a patch in 2 patients. The mean duration of clamping time was 41.9 (35–60) min. Portal vein thrombosis was encountered in 2 patients, and anastomotic stenosis in 1 patient. Other morbidity was not related to vascular reconstruction. One patient who underwent extended right hepatectomy and pancreaticoduodenectomy died of liver failure in the hospital. The serum creatinine level after surgery did not deteriorate except in the one patient who died in the hospital. Graft patency was maintained during the follow‐up period in all patients.ConclusionsA LRV graft may enhance the possibility of vascular reconstruction without deteriorating serum creatinine level, and it provides sound graft patency.
Optimization of Deacidification of Mixtures of Sunflower Oil and Oleic Acid in a Continuous Process
Authors: Prieto González M. M. , Bada J. C. , León M. , Graciani E. 
Published: April 2007

AbstractMixtures of refined sunflower seed oil and oleic acid were deacidified using nitrogen as stripping gas in a pilot‐plant scale continuous deodorizer. To optimize the process, two different levels were tested for the classical operating parameters of oil temperature, nitrogen flow rates, oil mass flow rates and initial free fatty acid contents. In addition, two heating procedures were tested, including one using separate electrical heating of the oil and gas distillates to maintain the same temperature in both parts of the deodorizer, and another in which only the oil was heated and controlled, resulting in a temperature difference between the oil and the gas distillates. The statistical technique of blocking with paired comparisons was used to analyze the final free fatty acid content, rate of free fatty acid loss with respect to the processed oil flow rate, free fatty acid content in the distillates recovered by condensation, and efficiency. The results showed that the oil temperature and maintaining the same temperature in the oil and the gas distillates produced the most relevant effects, having a positive effect on most of the responses.
Temperature Effects on the Deacidification of Mixtures of Sunflower Oil and Oleic Acid
Authors: Prieto González M. M. , Bada J. C. , Graciani E. 
Published: April 2007

AbstractAlthough it is well known that oil temperature is an essential factor for determining the deacidification mass rate and the final free fatty acids content, the influence of the temperature of the gas distillates above the liquid phase in the deodorizer on the oil temperature is much less understood. An extensive study of the effect of the temperature of the oil and of the gas distillates was undertaken in a continuous deodorizer, comparing the results with those obtained using a batch process. Variations in temperature from the temperature obtained without additional heating of the gases to a higher temperature than that of the oil were assayed for the gas distillates at the head of the deodorizer. It was possible to obtain low outlet free fatty acid contents at lower oil temperatures by controlling the overheating of the distillates, even for very high initial free fatty acids content, indicating that this is an essential variable to consider in distillation. However, increasing the temperature of the gas distillates above that of the oil sometimes produces a negative effect in deacidification.
Low‐trans Shortening and Spread Fats Produced by Electrochemical Hydrogenation
Authors: List G. R. , Warner K. , Pintauro P. , Gil M. 
Published: April 2007

AbstractPartially hydrogenated soybean oils (90–110 IV) were prepared by electrochemical hydrogenation at a palladium/cobalt or palladium/iron cathode, moderate temperature (70–90 °C) and atmospheric pressure. The trans fatty acid (TFA) contents of 90–110 IV products ranged from 6.4 to13.8% and the amounts of stearic acid ranged from 8.8 to 15.4% (the higher stearic acid contents indicated that some reaction selectivity had been lost). The solid fat values and melting point data indicated that electrochemical hydrogenation provides a route to low‐trans spreads and baking shortenings. Shortenings produced by conventional hydrogenation contain 12–25% trans fatty acids and up to 37% saturates, whereas shortening fats produced electrochemically had reduced TFA and saturate content. Electrochemical hydrogenation is also a promising route to low‐trans spread and liquid margarine oils. Compared to commercial margarine/spread oils containing 8–12% TFA, the use of electrochemical hydrogenation results in about 4% TFA.
Risikokalkulationen bei erblichen Krebserkrankungen
Authors: Fischer C. , Bickeböller H. 
Published: April 2007

Zusammenfassung
Wir konzentrieren uns auf Risikoberechnungen bei familiärem Brust- und Eierstockkrebs, da diese ein wichtiges Thema in der genetischen Beratung darstellen. Ratsuchende mit Mutationen in einem der beiden Gene BRCA1 oder BRCA2 haben eine sehr hohe Erkrankungswahrscheinlichkeit. Ist kein Test möglich oder dieser negativ, basiert die Entscheidung über eine intensivierte Vorsorge oder prophylaktische Maßnahmen auf Risikoberechnungen. Wir beschreiben einige der zugrunde liegenden Modelle sowie Untersuchungen zu deren vergleichender Validierung. Nur in einer prospektiven Studie wurden mehrere Modelle zur Berechnung der Brustkrebserkrankungswahrscheinlichkeit verglichen. Das einzige Modell in der Studie, das BRCA1/2, zusätzliche genetische Faktoren und einige weitere Risikofaktoren berücksichtigt (IBIS), zeigte die beste Vorhersagekraft. Es wurden nicht alle neueren Modelle berücksichtigt (kein BOADICEA) und keine neueren Risikofaktoren einbezogen.
Effects of long-term intervention with low- and high-glycaemic-index breakfasts on food intake in children aged 8–11 years
Authors: Henry C. Jeya K. , Lightowler Helen J. , Strik Caroline M. 
Published: April 2007

The aim of the present study was to investigate the effects of long-term intervention of low-glycaemic-index (GI) v. high-GI breakfasts on energy and macronutrient intakes in children aged 8–11 years. Preadolescent children were assigned to one of two groups in a random cross-over design. Each group was given low-GI and high-GI breakfasts on two non-consecutive days per week for 10 weeks per breakfast type. Each breakfast provided approximately 1273 kJ (300 kcal) and was closely matched for macronutrient and dietary fibre content. Subsequent food intake at an ad libitum buffet lunch was recorded and daily energy and macronutrient intakes were measured by 24 h recall and 3 d food diaries. There was a tendency towards a reduced energy intake at lunch following the low-GI breakfast compared with the high-GI breakfast, although the mean difference of 75 kJ (18 kcal) was not significant (P = 0·406). In particular, there was a trend towards a reduced energy intake in the low-GI arm compared with the high-GI arm among boys. In addition, data from the 3 d food diaries showed that there was a tendency towards a reduced energy intake during the low-GI compared with the high-GI study period. In conclusion, although the difference in energy intake following the low-GI and high-GI breakfasts was not statistically significant, the reduced energy intake following the low-GI breakfast is encouraging. Both dietary fibre and carbohydrate type may affect GI, thus their potential and relative modulating effect on appetite requires further investigation.
Tinnitus rehabilitation: a mindfulness meditation cognitive behavioural therapy approach
Authors: Sadlier M , Stephens S D G , Kennedy V 
Published: April 2007

AbstractBackground:Chronic tinnitus is a frequent symptom presentation in clinical practice. No drug treatment to date has shown itself to be effective. The aim of the present study was to investigate the effects of cognitive behavioural therapy and meditation in tinnitus sufferers.Methodology:Patients were selected from a dedicated tinnitus clinic in the Welsh Hearing Institute. A waiting list control design was used. Twenty-five chronic tinnitus sufferers were consecutively allocated to two groups, one receiving a cognitive behavioural therapy/meditation intervention of four one hour sessions with the other group waiting three months and subsequently treated in the same way, thereby acting as their own control. The main outcome was measured using the Hallam tinnitus questionnaire. A four to six month follow up was conducted.Results:These showed significant statistical reductions in tinnitus variables both in the active and also in the control group. Post-therapy, no significant change was found after the waiting list period. The improvement was maintained at the four to six month period.Conclusion:The positive findings give support for the use of cognitive behavioural therapy/meditation for chronic tinnitus sufferers.