bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrophil extracellular trap formation and its implications in nonsteroidal anti‐inflammatory drug‐induced small intestinal injury
Authors: Moriyama Eiji , Nadatani Yuji , Higashimori Akira , Otani Koji , Ominami Masaki , Fukunaga Shusei , Hosomi Shuhei , Tanaka Fumio , Taira Koichi , Fujiwara Yasuhiro , Watanabe Toshio 
Published: April 2024

AbstractBackground and AimNonsteroidal anti‐inflammatory drugs (NSAIDs) damage the small intestine via neutrophil infiltration driven by the mucosal invasion of enterobacteria. The antimicrobial function of neutrophils is partially dependent on neutrophil extracellular traps (NETs). Excessive NET formation has been associated with several inflammatory diseases. Here, we aimed to investigate the role of NETs in NSAID‐induced small intestinal damage using human samples and an experimental mouse model.MethodsHuman small intestine specimens were obtained from NSAID users during double‐balloon enteroscopy. Wild‐type, protein arginine deiminase 4 (PAD4) knockout, and antibiotic‐treated mice were administered indomethacin to induce small intestinal injury. The expression of NET‐associated proteins, including PAD4, citrullinated histone H3 (CitH3), cell‐free DNA, and myeloperoxidase (MPO), was evaluated.ResultsThe double‐positive stained area with CitH3 and MPO, which is specific for neutrophil‐derived extracellular traps, was significantly high in the injured small intestinal mucosa of NSAID users. In a mouse model, small intestinal damage developed at 6 h after indomethacin administration, accompanied by increased mRNA levels of interleukin‐1β and keratinocyte chemoattractant and elevated NET‐associated protein levels of PAD4, CitH3, and MPO in small intestine and serum levels of cell‐free DNA. Both genetic deletion and pharmacological inhibition of PAD4 attenuated this damage by reducing the mRNA expression of inflammatory cytokines and NET‐associated proteins. Furthermore, mice pretreated with antibiotics showed resistance to indomethacin‐induced small intestinal damage, with less NET formation.ConclusionThese results suggest that NETs aggravate NSAID‐induced small intestinal injury. Therefore, NET inhibition could be a potential treatment for NSAID‐induced small intestinal injury.
Streamlined benefit analysis of products based on the Sustainable Development Goals: Integrating the voice of society into life cycle sustainability assessment
Authors: Möller Martin , Grießhammer Rainer 
Published: April 2024

AbstractConducting benefit analyses used to be a controversial endeavor. In the absence of a consistent normative framework, indicators had to be determined on a case‐by‐case basis, requiring time‐consuming stakeholder workshops. The 2030 Agenda provided the missing normative basis to enable the inclusion of benefit aspects in life cycle sustainability assessment (LCSA). However, given the 17 Sustainable Development Goals and their 169 targets, it has remained unclear which of these targets relate to products and services and should therefore be used as indicators in benefit analyses. Against this background, this paper presents a consistent and well‐defined indicator framework for product‐related benefit analyses, developed through a detailed alignment with the 2030 Agenda and comprising a set of 30 indicators. It also describes how benefit analysis can be integrated into the LCSA methodology to provide a sound, evidence‐based framework for research and policy making: First, it outlines a sustainability self‐assessment tool for corporate researchers and designers, embedded in a Stage‐Gate process as a “voice‐of‐society” perspective. Second, it discusses approaches to improve regulatory impact assessment for policy making, particularly in the area of chemicals management. An illustrative case study shows how the developed benefit indicators can address current shortcomings in socio‐economic analysis methodology, such as an unbalanced focus on the economic impacts and insufficient information on human and environmental impacts. Despite its limitations, such as the inherent focus on societal benefits and existing “blind spots” in the 2030 Agenda, the indicator set has the potential to enrich LCSA studies with previously neglected aspects.
Environmental performance of eco‐design strategies applied to the building sector
Authors: Ipsen Kikki Lambrecht , Pizzol Massimo , Birkved Morten , Amor Ben 
Published: April 2024

AbstractThe application of eco‐design principles in the building sector is considered a promising way to mitigate its substantial environmental impacts. However, quantitative evidence for this mitigation potential is lacking. The objective of this study was to quantify the environmental performance of diverse eco‐design strategies when applied to the building sector. A macroscale model capable of simulating the future demand for housing and related material flows within the urban building stock was developed based on an existing building stock model. These material flows were used to build inventories for a consequential life cycle assessment and, in turn, to quantify the potential environmental consequences of introducing eco‐design strategies in the building sector, assessed across 16 impact categories. Model outputs have a high level of uncertainty but are still useful for decision‐making, given the model's simplicity and transparency. The main results show that impact reductions can be obtained from specific uses of wood and wooden products, for example, when used for the walls in high‐rise buildings, whereas using hempcrete for partition walls increases the impact. Although the use of adaptability or disassembly strategies can reduce impacts, this pay‐off can only be obtained after a long period of implementation. In summary, the present study provides new quantitative insights into the ability of eco‐design strategies to mitigate environmental impacts in the building sector.
Regional transformation pathways for the bioeconomy: A novel monitoring approach for complex transitions
Authors: Siekmann Florian , Venghaus Sandra 
Published: April 2024

AbstractAddressing the complexities of transitioning to a sustainable bioeconomy, this paper presents a novel approach for developing regional transformation pathways (RTPs) based on narratives derived from the shared socioeconomic pathways. The methodology emphasizes a comprehensive understanding of underlying perspectives and perceptions, incorporating socio‐economic, environmental, and political dimensions. The developed indicator framework captures a balanced representation of diverse interests by integrating insights from stakeholder analyses. The case study in the Rheinisches Revier region, Germany, exemplifies the approach's applicability, providing valuable insights for decision‐making processes in the context of regional transitions toward a low‐carbon economy. The results consist of five developed RTPs, offering a multitude of potential future trajectories of possible directions for regional transformations. Understanding potential pathways and related consequences is crucial for informed decision‐making concerning resource use optimization since transformations of that scale influence the composition of supply chains and resource networks. This informed approach contributes to strategic planning and helps ensure resources are utilized efficiently and sustainably. By emphasizing the crucial role of transparency and reflection of assumptions in addressing the complexities of societal transformation processes, our approach seeks to support the implementation of a sustainable and inclusive bioeconomy at the regional level.
Small particles, big effects: How nanoparticles can enhance plant growth in favorable and harsh conditions
Authors: Wang Jie , Wu Honghong , Wang Yichao , Ye Wuwei , Kong Xiangpei , Yin Zujun 
Published: April 2024

ABSTRACTBy 2050, the global population is projected to reach 9 billion, underscoring the imperative for innovative solutions to increase grain yield and enhance food security. Nanotechnology has emerged as a powerful tool, providing unique solutions to this challenge. Nanoparticles (NPs) can improve plant growth and nutrition under normal conditions through their high surface‐to‐volume ratio and unique physical and chemical properties. Moreover, they can be used to monitor crop health status and augment plant resilience against abiotic stresses (such as salinity, drought, heavy metals, and extreme temperatures) that endanger global agriculture. Application of NPs can enhance stress tolerance mechanisms in plants, minimizing potential yield losses and underscoring the potential of NPs to raise crop yield and quality. This review highlights the need for a comprehensive exploration of the environmental implications and safety of nanomaterials and provides valuable guidelines for researchers, policymakers, and agricultural practitioners. With thoughtful stewardship, nanotechnology holds immense promise in shaping environmentally sustainable agriculture amid escalating environmental challenges.
An indicator color chart for quick detection of Pigment Red 53 in cosmetic products in Indonesia
Authors: Pratiwi Rimadani , Agita Kiva , Hasanah Aliya Nur 
Published: April 2024

AbstractBackgroundPigment Red 53 is a dangerous synthetic dye that is often added to cosmetics, even though its use in cosmetic products has been prohibited because of possible impacts on health. Faster and more sensitive detection of Pigment Red 53 is needed for onsite analysis to protect the community from illegal cosmetics that contain the dye. Indicator color charts are a kind of analytical method that can be used to detect Pigment Red 53 in cosmetic products, including lipstick, rouge, and eyeshadow. Such charts are practical, fast, and can be used for onsite analysis.MethodsIn this study, an indicator for Pigment Red 53 detection was obtained through a reagent reaction that caused a specific color change. An indicator color chart was then produced by setting out in paper form the series of colors which resulted from the reaction of specific chemical reagents and Pigment Red 53 solutions at concentrations of 10, 20, 40, 60, 80, and 100 ppm.ResultsThe testing results showed that the indicator color chart may be used as an initial screening method for the detection of Pigment Red 53 in cosmetic products with a detectable minimum concentration of 10 ppm. Out of nine samples, only one (Eyeshadow 3) tested positive for Pigment Red 53. Further analysis was carried out on the indicator color chart and the results showed good agreement with TLC and UV–Vis spectrophotometry methods.ConclusionThe results reported in this paper demonstrate that the indicator color chart is a good prospective method for onsite analysis to detect Pigment Red 53 in cosmetic samples, with a lower detection limit compared to polymer‐based indicators.
Same model, same data, but different outcomes: Evaluating the impact of method choices in structural equation modeling
Authors: Sarstedt Marko , Adler Susanne J. , Ringle Christian M. , Cho Gyeongcheol , Diamantopoulos Adamantios , Hwang Heungsun , Liengaard Benjamin D. 
Published: April 2024

AbstractScientific research demands robust findings, yet variability in results persists due to researchers' decisions in data analysis. Despite strict adherence to state‐of the‐art methodological norms, research results can vary when analyzing the same data. This article aims to explore this variability by examining the impact of researchers' analytical decisions when using different approaches to structural equation modeling (SEM), a widely used method in innovation management to estimate cause–effect relationships between constructs and their indicator variables. For this purpose, we invited SEM experts to estimate a model on absorptive capacity's impact on organizational innovation and performance using different SEM estimators. The results show considerable variability in effect sizes and significance levels, depending on the researchers' analytical choices. Our research underscores the necessity of transparent analytical decisions, urging researchers to acknowledge their results' uncertainty, to implement robustness checks, and to document the results from different analytical workflows. Based on our findings, we provide recommendations and guidelines on how to address results variability. Our findings, conclusions, and recommendations aim to enhance research validity and reproducibility in innovation management, providing actionable and valuable insights for improved future research practices that lead to solid practical recommendations.
Neuropsychological functioning and its correlates at 1 year follow‐up of severe COVID‐19
Authors: Costas‐Carrera Ana , Sánchez‐Rodríguez Marta Mónica , Ojeda Antonio , Rodríguez‐Rey Manuel Arturo , Martín‐Villalba Inés , Primé‐Tous Mireia , Valdesoiro‐Pulido Francisco , Segú Xavier , Borras Roger , Clougher Derek , Peri Josep Maria , Vieta Eduard 
Published: April 2024

AbstractBackgroundShort‐term cognitive impairment is associated with SARS‐CoV‐2 infection but the long‐term impact is yet to be examined in detail. We aim to study the evolution of these symptoms in severe COVID‐19 patients admitted to the intensive care unit (ICU) between April and December 2020 1 year after hospital discharge and to analyze its clinical correlates.MethodA total of 58 patients agreed to participate in the 6 months follow‐up and 30 at 1 year after hospital discharge. Demographic, clinical and laboratory data were collected and a comprehensive neuropsychological battery including validated tests for the main cognitive domains was administered. To test the magnitude of neurocognitive sequelae, two standard deviations below normative group were considered. To compare the neuropsychological performance at 6 and 12 months follow‐up we used repeated measures tests. Finally, regression analyses were performed to test the main effects of medical and psychological factors on multiple cognition.ResultsAlmost half of the sample continued to have impaired performance on neuropsychological tests at 12 months follow‐up. In comparison with the results obtained at 6 months, significant improvements were found in immediate recall (d = 0.49), delayed recall (d = 0.45), and inhibitory control (d = 0.53). Medical variables predicted cognitive performance at 6 months but not at 12 months follow‐up, while anxiety and depression predicted cognitive deficits in the long‐term.ConclusionsA generalised improvement was observed in severe COVID‐19 patients at follow‐up. This improvement was particularly notable in verbal memory and executive functioning. However, a considerable proportion of the sample continued to present deficits at 1 year follow‐up.
Associations between neighbourhood safety, social cohesion, sleep quality and sleep duration among older adults in India: Findings from the Study on Global Aging and Adult Health (WHO‐SAGE), 2015
Authors: Muhammad T. , Pai Manacy , Anil Kumar A.H. Sruthi , Lekshmi P.R. , Sekher T.V 
Published: April 2024

AbstractBackgroundMost studies on later‐life health in India focus on families, with far less attention given to the health repercussions of neighbourhood conditions among older Indians. We address this limitation in existing research by examining the associations between perceptions of neighbourhood safety and social cohesion and sleep duration and sleep quality among older adults in India.MethodsData come from the Study on Global Aging and Adult Health (WHO‐SAGE), India 2015 wave 2, with a sample of 7118 adults aged 50 years and above. Sleep quality and duration were assessed using subjective responses. Multivariable logistic and linear regression analyses were employed to test the research hypotheses.ResultsPrevalence of poor sleep quality was higher among older adults living in unsafe neighbourhoods (4.46%) than peers residing in safe neighbourhoods (3.52%), and it was also higher among those living in neighbourhoods with poor social cohesion (5.31%) than counterparts who lived in socially cohesive communities (3.10%). Older adults in neighbourhoods with poor social cohesion had higher odds of reporting compromised sleep quality (adjusted odds ratio 1.75, CI: 1.22–2.51) than those living in socially cohesive neighbourhoods. Moreover, compared to those who perceived they were living in safe neighbourhoods, their peers who perceived their neighbourhoods as unsafe reported shorter sleep duration, with a negative beta coefficient of −0.27 (CI: −0.45 to −0.085).ConclusionThat perceived unsafety and poor social cohesion within one's neighbourhood are associated with compromised sleep reflects the significance of making neighbourhoods safer and more integrated for later‐life sleep health. In addition to micro‐level strategies (e.g., balanced nutrition and physical activity), efforts to improve sleep health should optimise macro‐level opportunities, such as rehabilitating and revitalising neighbourhoods, which may alleviate sleep disturbances and improve sleep outcomes among older adults.
Minority stressors and suicidal ideation in sexual minority individuals across adulthood
Authors: Canen Jenessa M. , Brausch Amy M. 
Published: April 2024

AbstractBackgroundSuicidal ideation occurs at relatively high rates among adults identifying as sexual minorities compared to those identifying as heterosexual, and minority stress is one explanation for this disparity. Minority stress is known to associate with increased suicidal ideation, but research on how minority stress associates with suicidal ideation in sexual minority adults across the adult lifespan is lacking.MethodsData were collected online from 284 sexual minority adults ranging in age from 18 to 85. Participants were recruited from Prolific and completed self‐report measures assessing past‐month suicidal ideation and multiple sexual minority stressors.ResultsThe minority stressors of acceptance concerns, concealment motivation, and difficulty processing one's identity were positively correlated with likelihood of past‐month suicidal deation. Age moderated the relationship between two minority stressors and suicidal ideation: identity uncertainty and internalized homonegativity. These relationships were only significant among older adults, compared to middle‐age and younger adults.ConclusionSpecific internalized minority stressors about one's sexual identity were significantly associated with past‐month suicidal ideation for older adults. More research is needed on how minority stress impacts recent suicidal ideation for sexual minority adults across the lifespan.
Severe acute respiratory syndrome coronavirus 2 infection in hematopoietic stem cell transplant recipients in Mexico City
Authors: Martinez‐Rivera Nancy , Franco Daniel , Acosta‐Maldonado Brenda L. , Alatorre‐Fernandez Pamela , Islas‐Muñoz Beda , Perez‐Jimenez Carolina , Martin‐Onraet Alexandra 
Published: April 2024

AbstractBackgroundHematopoietic stem cell transplant (HSCT) recipients are among patients with highest risk of adverse coronavirus disease 2019 (COVID‐19) outcomes.ObjectiveWe compared clinical outcomes in post‐HSCT patients with COVID‐19 before and during the Omicron period.Study DesignThis was a retrospective study including patients post‐HSCT with severe acute respiratory syndrome coronavirus 2 infection from April 2020 to March 2023 at Instituto Nacional de Cancerología, Mexico City. We describe their clinical characteristics and report the variables associated with severe clinical disease, hospitalization, and death.ResultsFifty‐three patients were included; 31 (58.5%) from the pre‐Omicron period and 22 (41.5%) from the Omicron period. Median age was 42‐years old (interquartile range 26–53), and 31 patients (59%) were men. Only four patients (16%) had received a vaccine prior to COVID‐19 diagnosis in the pre‐Omicron period versus 20 (91%) in the Omicron period (p < 0.001). COVID‐19 severe cases were more common before Omicron: seven patients (23%) versus two patients (9%). Only one patient (3%) received an antiviral in the pre‐Omicron period compared to 11 patients (50%) during the Omicron period (p < 0.01). COVID‐19‐associated mortality was almost double in the pre‐Omicron period (16% vs. 9%, p = 0.6).ConclusionsThis study reports patients with a high proportion of severe outcomes during the first 2 years of the pandemic. Outcomes improved during Omicron with better access to vaccines and antivirals and no in‐hospital cases. Variables associated with worse outcomes were similar to other reports. Strengthening infection control measures in the hospital and better access to preventive strategies and therapeutic options are mandatory in these high‐risk patients.
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Nutri‐cereal tissue‐specific transcriptome atlas during development: Functional integration of gene expression to identify mineral uptake pathways in little millet (Panicum sumatrense)
Authors: Pahari Shankar , Vaid Neha , Soolanayakanahally Raju , Kagale Sateesh , Pasha Asher , Esteban Eddi , Provart Nicholas , Stobbs Jarvis A. , Vu Miranda , Meira Debora , Karunakaran Chithra , Boda Praveen , Prasannakumar Mothukapalli K. , Nagaraja Alur , Jain Ashwani Kumar 
Published: April 2024

SUMMARYLittle millet (Panicum sumatrense Roth ex Roem. & Schult.) is an essential minor millet of southeast Asia and Africa's temperate and subtropical regions. The plant is stress‐tolerant, has a short life cycle, and has a mineral‐rich nutritional profile associated with unique health benefits. We report the developmental gene expression atlas of little millet (genotype JK‐8) from ten tissues representing different stages of its life cycle, starting from seed germination and vegetative growth to panicle maturation. The developmental transcriptome atlas led to the identification of 342 827 transcripts. The BUSCO analysis and comparison with the transcriptomes of related species confirm that this study presents high‐quality, in‐depth coverage of the little millet transcriptome. In addition, the eFP browser generated here has a user‐friendly interface, allowing interactive visualizations of tissue‐specific gene expression. Using these data, we identified transcripts, the orthologs of which in Arabidopsis and rice are involved in nutrient acquisition, transport, and response pathways. The comparative analysis of the expression levels of these transcripts holds great potential for enhancing the mineral content in crops, particularly zinc and iron, to address the issue of “hidden hunger” and to attain nutritional security, making it a valuable asset for translational research.