bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poems Syndrome and Disease Produced by Other Monoclonal IGs
Authors: Cook Gordon , Rovira Montserrat 
Published: April 2024

AbstractPOEMS syndrome (acronym of: polyradiculoneuropathy, organomegaly, endocrinopathies, monoclonal protein and dermopathy/§skin) is a rare multisystemic disease due to an underlying plasma cell neoplasm. The pathogenesis of the syndrome is not well understood. Other names of the POEMS syndrome that are less frequently used are osteosclerotic myeloma, Takatsuki syndrome, or Crow-Fukase syndrome.
Histocompatibility
Authors: Spierings Eric , Madrigal Alejandro , Fleischhauer Katharina 
Published: April 2024

AbstractHuman leukocyte antigen (HLA) molecules are the most important histocompatibility antigens, due to their genetic polymorphism and their key role in peptide antigen presentation and T-cell alloreactivity. While full matching for the most relevant HLA loci had been regarded as a prerequisite for successful transplantation until recently, the introduction of posttransplant cyclophosphamide (PTCy) as immune prophylaxis has also allowed successful transplantation across multiple HLA mismatches, thus also enabling access to transplantation for patients without a fully compatible donor. The rules governing high-risk/nonpermissive HLA mismatches, identified in the past as immunopeptidome overlaps, expression levels, and predicted indirectly recognized HLA epitopes (PIRCHEs), will have to be redefined in the PTCy area to further improve patient outcomes.
Institutional Norms and the Cost of Doing Politics
Authors: Sawer Marian , Maley Maria 
Published: April 2024

AbstractWomen entering non-traditional workplaces commonly experience hostility in the form of sexual harassment. The parliamentary workplace has additional features that make reform difficult, despite feminist standard-setting in transnational bodies. Difficulties include applying employment law to MPs who are not employees in any real sense themselves but have almost complete power over their staff. Adversarial traditions normalise aggressive conduct rather than a respectful workplace and also make it likely that any complaint will be weaponised politically. Many are silenced by fear that to complain will damage their party as well as their own career. Another obstacle to reform has been the tradition of parliamentary privilege, the right of parliaments to regulate their own affairs free from external interference. This has held back the introduction of professional employment standards, on the grounds that the best form of accountability for parliamentarians is at the ballot box.
Citizens’ data afterlives: Practices of dataset inclusion in machine learning for public welfare
Authors: Ratner Helene Friis , Thylstrup Nanna Bonde 
Published: April 2024

AbstractPublic sector adoption of AI techniques in welfare systems recasts historic national data as resource for machine learning. In this paper, we examine how the use of register data for development of predictive models produces new ‘afterlives’ for citizen data. First, we document a Danish research project’s practical efforts to develop an algorithmic decision-support model for social workers to classify children’s risk of maltreatment. Second, we outline the tensions emerging from project members’ negotiations about which datasets to include. Third, we identify three types of afterlives for citizen data in machine learning projects: (1) data afterlives for training and testing the algorithm, acting as ‘ground truth’ for inferring futures, (2) data afterlives for validating the algorithmic model, acting as markers of robustness, and (3) data afterlives for improving the model’s fairness, valuated for reasons of data ethics. We conclude by discussing how, on one hand, these afterlives engender new ethical relations between state and citizens; and how they, on the other hand, also articulate an alternative view on the value of datasets, posing interesting contrasts between machine learning projects developed within the context of the Danish welfare state and mainstream corporate AI discourses of the bigger, the better.
Identification of β-aspartic semialdehyde and homocysteine as major reaction products of riboflavin-sensitized photooxidation of peptide-bound methionine
Authors: Krax Raphaela , Menneking Kira , Sajapin Johann , Hellwig Michael 
Published: April 2024

AbstractMethionine is an essential amino acid for mammals and it is limiting for monogastric animals. It can be oxidized easily by UV light. This could influence the bioaccessibility and bioavailability of methionine. In this work, the photosensitized degradation of peptide-bound methionine in the presence of riboflavin was investigated in a model system. Capillary electrophoresis was employed to analyze the time course of the degradation. The products were identified by liquid chromatography coupled to mass spectrometry (LC–MS/MS). Benzoyl methionine was degraded by 50% during UV irradiation in the presence of riboflavin after 5.0 min with 10 mol% riboflavin and 6.4 min with 3 mol% riboflavin. Homocysteine (16–20 mol%) and β-aspartic semialdehyde (ca. 30 mol%) were found as major degradation products next to methionine sulfoxide (ca. 25 mol%). A smaller molar ratio of riboflavin led to a higher formation of aspartic semialdehyde. The formation of homocysteine was paralleled by the formation of formaldehyde. Furthermore, the experiment was transferred to small peptides, which showed the analogous degradation products of peptide-bound methionine.
Persistence of heterodimensional cycles
Authors: Li Dongchen , Turaev Dmitry 
Published: April 2024

AbstractA heterodimensional cycle is an invariant set of a dynamical system consisting of two hyperbolic periodic orbits with different dimensions of their unstable manifolds and a pair of orbits that connect them. For systems which are at least $C^{2}$

C
2

, we show that bifurcations of a coindex-1 heterodimensional cycle within a generic 2-parameter family create robust heterodimensional dynamics, i.e., a pair of non-trivial hyperbolic basic sets with different numbers of positive Lyapunov exponents, such that the unstable manifold of each of the sets intersects the stable manifold of the second set and these intersections persist for an open set of parameter values. We also give a solution to the so-called local stabilization problem of coindex-1 heterodimensional cycles in any regularity class $r=2,\ldots ,\infty ,\omega $
r
=
2
,
…
,
∞
,
ω
. The results are based on the observation that arithmetic properties of moduli of topological conjugacy of systems with heterodimensional cycles determine the emergence of Bonatti-Díaz blenders.
To house or oust: Honey bee (Apis mellifera) colonies can evaluate and evict drones of low quality
Authors: Gilchrist Izaak R. , Nixon Jonathan M. , Shultz Riley R. , Ginzel Matthew D. , Harpur Brock A. 
Published: April 2024

Abstract
Across the animal kingdom, males advertise their quality to potential mates. Males of low reproductive quality, such as those that are sick, may be excluded from mating. In eusocial species, there is some evidence that reproductive females gauge the quality of their mates. However, males often spend much more time with non-reproductive females when being raised or when returning from unsuccessful mating flights. Do non-reproductive workers evaluate the quality of male reproductives? Here we address this question using male honey bees (Apis mellifera), called drones, as a model. We generated immune-challenged drones by injecting them with lipopolysaccharide and tested: 1) do workers evict immune-challenged drones from their colony, 2) do cuticular hydrocarbon (CHC) profiles, body size, or mass change when drones are immune-challenged, and 3) are these changes used by workers to exclude low quality males from the colony? We found that an immune challenge causes changes in CHC profiles of drones and reduces their body mass. Workers selectively evict small and immune-challenged drones who, themselves, do not self-evict. This work demonstrates that some eusocial males undergo an additional layer of scrutiny prior to mating mediated by the non-reproductive worker caste.

Significance statement
Males of some species must advertise their quality to mates but, in the case of eusocial species, must they also advertise their quality to nestmates? By manipulating honey bee male quality, we found that small and immune-challenged drones are evicted from colonies overnight. Workers may not use a drone’s cuticular hydrocarbon profile to make this assessment. This is a new example of social immunity expressed against adult males and an example of worker involvement in reproductive decisions.
Image-based biomarkers for engineering neuroblastoma patient-specific computational models
Authors: Hervas-Raluy Silvia , Sainz-DeMena Diego , Gomez-Benito Maria Jose , García-Aznar Jose Manuel 
Published: April 2024

AbstractChildhood cancer is a devastating disease that requires continued research and improved treatment options to increase survival rates and quality of life for those affected. The response to cancer treatment can vary significantly among patients, highlighting the need for a deeper understanding of the underlying mechanisms involved in tumour growth and recovery to improve diagnostic and treatment strategies. Patient-specific models have emerged as a promising alternative to tackle the challenges in tumour mechanics through individualised simulation. In this study, we present a methodology to develop subject-specific tumour models, which incorporate the initial distribution of cell density, tumour vasculature, and tumour geometry obtained from clinical MRI imaging data. Tumour mechanics is simulated through the Finite Element method, coupling the dynamics of tumour growth and remodelling and the mechano-transport of oxygen and chemotherapy. These models enable a new application of tumour mechanics, namely predicting changes in tumour size and shape resulting from chemotherapeutic interventions for individual patients. Although the specific context of application in this work is neuroblastoma, the proposed methodologies can be extended to other solid tumours. Given the difficulty for treating paediatric solid tumours like neuroblastoma, this work includes two patients with different prognosis, who received chemotherapy treatment. The results obtained from the simulation are compared with the actual tumour size and shape from patients. Overall, the simulations provided clinically useful information to evaluate the effectiveness of the chemotherapy treatment in each case. These results suggest that the biomechanical model could be a valuable tool for personalised medicine in solid tumours.
Handling of long-term storage in multi-horizon stochastic programs
Authors: Kaut Michal 
Published: April 2024

AbstractThis paper introduces a method for incorporating long-term storage into the multi-horizon modelling paradigm, thereby expanding the scope of problems that this approach can address. The implementation presented here is based on the HyOpt optimization model, but the underlying concepts are designed to be adaptable to other models that utilize the multi-horizon approach. We demonstrate the effects of several formulations on a case study that explores the electrification of an offshore installation using wind turbines and a hydrogen-based energy storage system. The findings suggest that the formulations offer a realistic modelling of storage capacity, without compromising the advantages of the multi-horizon approach.
Teaching through their eyes: effects on optometry teachers’ adaptivity and students’ learning when teachers see students’ gaze
Authors: Korteland Robert-Jan , Kok Ellen , Hulshof Casper , van Gog Tamara 
Published: April 2024

AbstractAdaptive teacher support fosters effective learning in one-to-one teaching sessions, which are a common way of learning complex visual tasks in the health sciences. Adaptive support is tailored to student needs, and this is difficult in complex visual tasks as visual problem-solving processes are covert and thus cannot be directly observed by the teacher. Eye-tracking apparatus can measure covert processes and make them visible in gaze displays: visualizations of where a student looks while executing a task. We investigate whether live dynamic gaze displays help teachers in being more adaptive to students’ needs when teaching optical coherence tomography interpretation in one-to-one teaching sessions and whether this fosters learning. Forty-nine students and 10 teachers participated in a one-to-one teaching session in clinical optometry. In the control condition, teachers saw the learning task of the student and could discuss it with them, whereas in the gaze-display condition, teachers could additionally see where the student looked. After the 15-minute teaching session, a test was administered to examine achievement. Furthermore, students filled in the ‘questionnaire on teacher support adaptivity’, and teachers rated how adaptive their support was. Bayesian analyses provide some initial evidence that students did not experience support to be more adaptive in the gaze-display condition versus the control condition, nor were their post-test scores higher. Teachers rated their provided support as being more adaptive in the gaze-display versus the control condition. Further research could investigate if live dynamic gaze displays impact adaptive teaching when used over longer periods or with more teacher training.
Adapted Beamforming: A Robust and Flexible Approach for Removing Various Types of Artifacts from TMS–EEG Data
Authors: Metsomaa Johanna , Song Yufei , Mutanen Tuomas P. , Gordon Pedro C. , Ziemann Ulf , Zrenner Christoph , Hernandez-Pavon Julio C. 
Published: April 2024

AbstractElectroencephalogram (EEG) recorded as response to transcranial magnetic stimulation (TMS) can be highly informative of cortical reactivity and connectivity. Reliable EEG interpretation requires artifact removal as the TMS-evoked EEG can contain high-amplitude artifacts. Several methods have been proposed to uncover clean neuronal EEG responses. In practice, determining which method to select for different types of artifacts is often difficult. Here, we used a unified data cleaning framework based on beamforming to improve the algorithm selection and adaptation to the recorded signals. Beamforming properties are well understood, so they can be used to yield customized methods for EEG cleaning based on prior knowledge of the artifacts and the data. The beamforming implementations also cover, but are not limited to, the popular TMS–EEG cleaning methods: independent component analysis (ICA), signal-space projection (SSP), signal-space-projection-source-informed-reconstruction method (SSP–SIR), the source-estimate-utilizing noise-discarding algorithm (SOUND), data-driven Wiener filter (DDWiener), and the multiple-source approach. In addition to these established methods, beamforming provides a flexible way to derive novel artifact suppression algorithms by considering the properties of the recorded data. With simulated and measured TMS–EEG data, we show how to adapt the beamforming-based cleaning to different data and artifact types, namely TMS-evoked muscle artifacts, ocular artifacts, TMS-related peripheral responses, and channel noise. Importantly, beamforming implementations are fast to execute: We demonstrate how the SOUND algorithm becomes orders of magnitudes faster via beamforming. Overall, the beamforming-based spatial filtering framework can greatly enhance the selection, adaptability, and speed of EEG artifact removal.
Healthier Food Choices: From Consumer Information to Consumer Empowerment in EU Law
Authors: Gokani N. 
Published: April 2024

AbstractThis article evaluates the European Union’s efforts to regulate consumer food information with the aim of improving consumer nutrition as part of its broader consumer protection agenda. With nearly a million deaths attributed to unhealthy diets annually, the EU’s New Consumer Agenda, its Farm to Fork Strategy, and Europe’s Beating Cancer Plan all highlight the objective of empowering consumers to make informed, healthy food choices. This underscores the EU’s longstanding emphasis on regulating information to protect consumers, an approach which is even stronger with nutrition more specifically. This article shows that the EU food information law is based on two beliefs. First, consumers are given food information that is sufficient, accurate, non-misleading, clear and easy to understand and they are, therefore, well-informed. Second, well-informed consumers are empowered. This article argues that both of these beliefs are misguided. The current food information rules do not truly inform consumers well and do not, on their own, empower consumers to make healthy dietary decisions. Consequently, this article expresses scepticism about the ability of the current rules to promote improved nutrition. In light of the critiques of the current rules, this article offers suggestions for an improved food information paradigm. In addition to rules that would more effectively inform consumers, such a paradigm would acknowledge the limitations of information to empower healthier food choices and, therefore, give greater weight to more substantive interventions. This would align food law with broader trends in consumer protection law and thereby genuinely promote healthier nutrition.
Algebraic properties of the maps $$\chi _n$$
Authors: Schoone Jan , Daemen Joan 
Published: April 2024

AbstractThe Boolean map$$\chi _n :\mathbb {F}_2^n \rightarrow \mathbb {F}_2^n,\ x \mapsto y$$χn:F2n→F2n,x↦ydefined by$$y_i = x_i + (x_{i+1}+1)x_{i+2}$$yi=xi+(xi+1+1)xi+2(where$$i\in \mathbb {Z}/n\mathbb {Z}$$i∈Z/nZ) is used in various permutations that are part of cryptographic schemes, e.g.,Keccak-f (the SHA-3-permutation), ASCON (the winner of the NIST Lightweight competition), Xoodoo, Rasta and Subterranean (2.0). In this paper, we study various algebraic properties of this map. We consider$$\chi _n$$χn(through vectorial isomorphism) as a univariate polynomial. We show that it is a power function if and only if$$n=1,3$$n=1,3. We furthermore compute bounds on the sparsity and degree of these univariate polynomials, and the number of different univariate representations. Secondly, we compute the number of monomials of given degree in the inverse of$$\chi _n$$χn(if it exists). This number coincides with binomial coefficients. Lastly, we consider$$\chi _n$$χnas a polynomial map, to study whether the same rule ($$y_i = x_i + (x_{i+1}+1)x_{i+2}$$yi=xi+(xi+1+1)xi+2) gives a bijection on field extensions of$$\mathbb {F}_2$$F2. We show that this is not the case for extensions whose degree is divisible by two or three. Based on these results, we conjecture that this rule does not give a bijection on any extension field of$$\mathbb {F}_2$$F2.
Identifying and testing drivers of consumers’ attitude towards last-mile delivery modes
Authors: Klink Benjamin Dominique , Schweizer Samuel 
Published: April 2024

AbstractMany online businesses strive to optimize last-mile delivery cost by implementing delivery modes aimed at cutting costs through automation or collaboration. Convincing consumers to adopt cost-efficient last-mile delivery modes is imperative to successfully achieve this goal. Yet, evidence on consumers’ attitude towards different delivery modes is scarce and causes of differences in attitude are currently not well understood. Based on qualitative interviews with e-food industry experts, we identify potential drivers of consumers’ attitude towards last-mile delivery modes. We test these drivers experimentally, finding privacy concerns to fully mediate differences in attitude of in-home and in-garage delivery when compared to timed in-person delivery. In addition, we find evidence indicating the presence of privacy calculus in delivery mode choice. Next to reducing customer risk, providing added customer value could therefore be a viable approach to encourage consumer adoption of more cost-efficient last-mile delivery.
Evaluation of Siblings’ Perceived Relationship Outcomes with Their Parents in an Open Trial of the SIBS Intervention for Children with Chronic Disorders
Authors: Fredriksen Trude , Vatne Torun M. , Haukeland Yngvild B. , Czajkowski Nikolai O. , Wakefield Claire E. , Fjermestad Krister W. 
Published: April 2024

AbstractThe SIBS intervention aims to prevent mental health problems for siblings of children with chronic disorders and has shown promising results. The mechanisms behind these changes have not been examined. Parent-child relationship quality is a predictor of mental health in siblings. Our first objective was to investigate whether sibling-perceived relationship quality between siblings and parents changes over time after participating in SIBS. Second, as the intervention requires participation of only one parent, we examined with a dual scale (anxiety and avoidance attachment style) whether relationship quality was associated with which parent participated. Third, as SIBS aims to promote parents‘ communication skills, we examined whether sibling-perceived communication quality with parents predicted relationship quality over time. The sample comprised 99 siblings (M = 11.5 years, SD = 2.0; range 8–16; 54% girls, 46% boys) of children with chronic disorders and one parent per sibling (63% mothers). We administered the questionnaires at pre-intervention, at three- and 6-months post-intervention. We applied growth curve models for relationship quality over time with communication quality as a predictor, controlling for parent gender. We found significant improvement in sibling-perceived relationship quality with the participating and the non-participating parent on the relationship anxiety scale over time, with small to medium effect sizes. Higher communication quality significantly predicted improvement of relationship quality in all four relationship outcomes. We conclude that change in relationship quality may be part of the positive outcomes of the SIBS intervention and is mainly explained by communication enhancement. Controlled trials of the SIBS intervention are indicated.
Learning Reliable Dense Pseudo-Labels for Point-Level Weakly-Supervised Action Localization
Authors: Dang Yuanjie , Zheng Guozhu , Chen Peng , Gao Nan , Huan Ruohong , Zhao Dongdong , Liang Ronghua 
Published: April 2024

AbstractPoint-level weakly-supervised temporal action localization aims to accurately recognize and localize action segments in untrimmed videos, using only point-level annotations during training. Current methods primarily focus on mining sparse pseudo-labels and generating dense pseudo-labels. However, due to the sparsity of point-level labels and the impact of scene information on action representations, the reliability of dense pseudo-label methods still remains an issue. In this paper, we propose a point-level weakly-supervised temporal action localization method based on local representation enhancement and global temporal optimization. This method comprises two modules that enhance the representation capacity of action features and improve the reliability of class activation sequence classification, thereby enhancing the reliability of dense pseudo-labels and strengthening the model’s capability for completeness learning. Specifically, we first generate representative features of actions using pseudo-label feature and calculate weights based on the feature similarity between representative features of actions and segments features to adjust class activation sequence. Additionally, we maintain the fixed-length queues for annotated segments and design a action contrastive learning framework between videos. The experimental results demonstrate that our modules indeed enhance the model’s capability for comprehensive learning, particularly achieving state-of-the-art results at high IoU thresholds.