bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital inclusive finance, green technological innovation, and carbon emissions from a spatial perspective
Authors: Lu Yang , Xia Ziyi 
Published: April 2024

AbstractBased on the panel data of 276 prefecture-level cities in China from 2011 to 2020, this study explores the impact of digital inclusive finance (DIF) on carbon emissions and the intrinsic mechanism of green technological innovation from a spatial perspective by constructing a spatial econometric model, a mediating effect model, and a threshold model. The results show that DIF significantly inhibits carbon emissions, exhibiting a spatial spillover effect. The transmission mechanism from a spatial perspective shows that green technological innovation plays a partial mediating role between DIF and carbon emissions, with the mediating effect accounting for approximately 59.47%. The heterogeneity analysis suggests that the impact of DIF on the reduction of carbon emissions is more pronounced in large and medium-sized cities and eastern regions. Further discussion reveals that the carbon reduction effect of DIF is also influenced by green technological innovation and industrial structure upgrading, showing threshold effects with marginal decreases and gradual increases, respectively.
Convolutional neural network algorithm trained on lumbar spine radiographs to predict outcomes of transforaminal epidural steroid injection for lumbosacral radicular pain from spinal stenosis
Authors: Kim Jeoung Kun , Chang Min Cheol 
Published: April 2024

AbstractLittle is known about the therapeutic outcomes of transforaminal epidural steroid injection (TFESI) in patients with lumbosacral radicular pain due to lumbar spinal stenosis (LSS). Using lumbar spine radiographs as input data, we trained a convolutional neural network (CNN) to predict therapeutic outcomes after lumbar TFESI in patients with lumbosacral radicular pain caused by LSS. We retrospectively recruited 193 patients for this study. The lumbar spine radiographs included anteroposterior, lateral, and bilateral (left and right) oblique views. We cut each lumbar spine radiograph image into a square shape that included the vertebra corresponding to the level at which the TFESI was performed and the vertebrae juxta below and above that level. Output data were divided into “favorable outcome” (≥ 50% reduction in the numeric rating scale [NRS] score at 2 months post-TFESI) and “poor outcome” (< 50% reduction in the NRS score at 2 months post-TFESI). Using these input and output data, we developed a CNN model for predicting TFESI outcomes. The area under the curve of our model was 0.920. Its accuracy was 87.2%. Our CNN model has an excellent capacity for predicting therapeutic outcomes after lumbar TFESI in patients with lumbosacral radicular pain induced by LSS.
Tunable magnetic confinement effect in a magnetic superlattice of graphene
Authors: Tosun Onur , Sarkar Preetha , Qian Chang , Gilbert Matthew , Chen Qian , Mason Nadya 
Published: April 2024

AbstractTwo-dimensional van der Waals materials such as graphene present an opportunity for band structure engineering using custom superlattice potentials. In this study, we demonstrate how self-assemblies of magnetic iron-oxide (Fe3O4) nanospheres stacked on monolayer graphene generate a proximity-induced magnetic superlattice in graphene and modify its band structure. Interactions between the nanospheres and the graphene layer generate superlattice Dirac points in addition to a gapped energy spectrum near the K and K′ valleys, resulting in magnetic confinement of quasiparticles around the nanospheres. This is evidenced by gate-dependent resistance oscillations, observed in our low temperature transport measurements, and confirmed by self-consistent tight binding calculations. Furthermore, we show that an external magnetic field can tune the magnetic superlattice potential created by the nanospheres, and thus the transport characteristics of the system. This technique for magnetic-field-tuned band structure engineering using magnetic nanostructures can be extended to a broader class of 2D van der Waals and topological materials.
Satellite-based entanglement distribution and quantum teleportation with continuous variables
Authors: Gonzalez-Raya Tasio , Pirandola Stefano , Sanz Mikel 
Published: April 2024

AbstractAdvances in satellite quantum communications aim at reshaping the global telecommunication network by increasing the security of the transferred information. Here, we study the effects of atmospheric turbulence in continuous-variable entanglement distribution and quantum teleportation in the optical regime between a ground station and a satellite. More specifically, we study the degradation of entanglement due to various error sources in the distribution, namely, diffraction, atmospheric attenuation, turbulence, and detector inefficiency, in both downlink and uplink scenarios. As the fidelity of a quantum teleportation protocol using these distributed entangled resources is not sufficient, we include an intermediate station for either state generation, or beam refocusing, in order to reduce the effects of atmospheric turbulence and diffraction, respectively. The results show the feasibility of free-space entanglement distribution and quantum teleportation in downlink paths up to the LEO region, but also in uplink paths with the help of the intermediate station. Finally, we complete the study with microwave-optical comparison in bad weather situations, and with the study of horizontal paths in ground-to-ground and inter-satellite quantum communication.
Equivariant 3D-conditional diffusion model for molecular linker design
Authors: Igashov Ilia , Stärk Hannes , Vignac Clément , Schneuing Arne , Satorras Victor Garcia , Frossard Pascal , Welling Max , Bronstein Michael , Correia Bruno 
Published: April 2024

AbstractFragment-based drug discovery has been an effective paradigm in early-stage drug development. An open challenge in this area is designing linkers between disconnected molecular fragments of interest to obtain chemically relevant candidate drug molecules. In this work, we propose DiffLinker, an E(3)-equivariant three-dimensional conditional diffusion model for molecular linker design. Given a set of disconnected fragments, our model places missing atoms in between and designs a molecule incorporating all the initial fragments. Unlike previous approaches that are only able to connect pairs of molecular fragments, our method can link an arbitrary number of fragments. Additionally, the model automatically determines the number of atoms in the linker and its attachment points to the input fragments. We demonstrate that DiffLinker outperforms other methods on the standard datasets, generating more diverse and synthetically accessible molecules. We experimentally test our method in real-world applications, showing that it can successfully generate valid linkers conditioned on target protein pockets.
A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells
Authors: Han Yunqiao , Sun Kui , Yu Shanshan , Qin Yayun , Zhang Zuxiao , Luo Jiong , Hu Hualei , Dai Liyan , Cui Manman , Jiang Chaolin , Liu Fei , Huang Yuwen , Gao Pan , Chen Xiang , Xin Tianqing , Ren Xiang , Wu Xiaoyan , Song Jieping , Wang Qing , Tang Zhaohui , Chen Jianjun , Zhang Haojian , Zhang Xianqin , Liu Mugen , Luo Daji 
Published: April 2024

AbstractPrenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m6A) methyltransferase, has hampered characterization of the essential role of METTL16-mediated RNA m6A modification in early embryonic development. Here, using cross-species single-cell RNA sequencing analysis, we found that during early embryonic development, METTL16 is more highly expressed in vertebrate hematopoietic stem and progenitor cells (HSPCs) than other methyltransferases. In Mettl16-deficient zebrafish, proliferation capacity of embryonic HSPCs is compromised due to G1/S cell cycle arrest, an effect whose rescue requires Mettl16 with intact methyltransferase activity. We further identify the cell-cycle transcription factor mybl2b as a directly regulated by Mettl16-mediated m6A modification. Mettl16 deficiency resulted in the destabilization of mybl2b mRNA, likely due to lost binding by the m6A reader Igf2bp1 in vivo. Moreover, we found that the METTL16-m6A-MYBL2-IGF2BP1 axis controlling G1/S progression is conserved in humans. Collectively, our findings elucidate the critical function of METTL16-mediated m6A modification in HSPC cell cycle progression during early embryonic development.
Facile preparation of a water-based antireflective SiO2 film with high transmittance for perovskite solar cells
Authors: Zhang Xuemin , Wang Ziao , Hou Peiran , Wu Senwei , Lu Jianfeng , Zhao Xiujian , Tian Shouqin 
Published: April 2024

An aqueous SiO2 AR film was prepared using sol–gel method and exhibited a high increase in transmittance of 3.5% compared to bare glass, leading to a 1.44% increase in the photovoltaic conversion efficiency of perovskite solar cells.
A closed‐loop representative day selection framework for generation and transmission expansion planning with demand response
Authors: Liu Haicheng , Li Haotian , Liu Hongli , Gu Chenjia , Li Qingtao , Ren Qiangyu 
Published: April 2024

AbstractIn power systems with a high proportion of renewable energy resources (RES), the inherent stochasticity and volatility of RES necessitate careful consideration in power system planning. Scenario analysis is commonly employed to address the stochastic nature in power system planning. Existing studies generally adopt an open‐loop structure, where representative days are selected first and planning decisions are subsequently made. However, this method may not accurately represent the operating status of a system owing to changes in the power generation structure during the planning process. To address this limitation, this paper introduces a closed‐loop framework for representative day selection within the context of generation and transmission expansion planning (G&TEP), incorporating demand response (DR). The framework comprises three layers: representative day selection, planning decisions, and long‐term operational simulation. Initially, an approach for selecting representative days is proposed by combining the clustering and optimization‐based methods. Subsequently, a G&TEP model that incorporates DR is presented in the second layer. Lastly, the framework encompasses a three‐layer closed‐loop structure, enabling dynamic adjustments and enhancements to the representative day selection process to ensure optimality. Case studies on the reliability and operational test system of a power grid with large‐scale renewable integration (XJTU‐ROTS) demonstrate the effectiveness of our proposed framework.
A novel meta‐learning network for partial discharge source localization in gas‐insulated switchgear via digital twin
Authors: Yan Jing , Wang Yanxin , Zhou Yang , Wang Jianhua , Geng Yingsan 
Published: April 2024

AbstractDue to the requirement for highly precise synchronous sampling and the substantial reliance on time difference calculations, the current partial discharge (PD) localization based on the time difference of arrival is only applicable in certain situations. As digital twin technology has advanced, it is possible to employ virtual models to support gas‐insulated switchgear (GIS) PD localization. To do this, we propose a meta‐learning (ML) network with the aid of digital twin for actual GIS PD localization. Firstly, a GIS digital twin model was established to acquire an auxiliary simulated sample library. Then, a temporal convolutional network is established to extract the discriminable features, effectively obtain the time dependence between features, and improve the accuracy of localization. Next, ML is adopted to quickly learn meta‐knowledge that can be applied across tasks, and the model's sensitivity to task changes is improved. Finally, the model is fine‐tuned through a limited number of samples from the target task, and high precise PD localization is achieved. The experimental results demonstrate that the ML has an average localization error of only 9.25 cm and a probability density rose to 93% within 20 cm, which is clearly superior to previous methods.
Prevalence of tick-borne pathogens in ticks collected from the wild mountain ungulates mouflon and chamois in 4 regions of France
Authors: Habib Jad , Zenner Lionel , Garel Mathieu , Mercier Antoine , Poirel Marie-Thérèse , Itty Christian , Appolinaire Joël , Amblard Thibaut , Benedetti Pierre , Sanchis Frédéric , Benabed Slimania , Abi Rizk Georges , Gibert Philippe , Bourgoin Gilles 
Published: April 2024

Ticks are major vectors of various pathogens of health importance, such as bacteria, viruses and parasites. The problems associated with ticks and vector-borne pathogens are increasing in mountain areas, particularly in connection with global climate change. We collected ticks (n = 2,081) from chamois and mouflon in 4 mountainous areas of France. We identified 6 tick species: Ixodes ricinus, Rhipicephalus bursa, Rh. sanguineus s.l., Haemaphysalis sulcata, H. punctata and Dermacentor marginatus. We observed a strong variation in tick species composition among the study sites, linked in particular to the climate of the sites. We then analysed 791 ticks for DNA of vector-borne pathogens: Babesia/Theileria spp., Borrelia burgdorferi s.l., Anaplasma phagocytophilum, A. marginale, A. ovis, and Rickettsia of the spotted fever group (SFG). Theileria ovis was detected only in Corsica in Rh. bursa. Babesia venatorum (2 sites), Borrelia burgdorferi s.l. (B. afzelii and B. garinii; 2 sites) and Anaplasma phagocytophilum (3 sites) were detected in I. ricinus. Anaplasma ovis was detected at one site in I. ricinus and Rh. sanguineus s.l. SFG Rickettsia were detected at all the study sites: R. monacensis and R. helvetica in I. ricinus at the 3 sites where this tick is present; R. massiliae in Rh. sanguineus s.l. (1 site); and R. hoogstraalii and Candidatus R. barbariae in Rh. bursa in Corsica. These results show that there is a risk of tick-borne diseases for humans and domestic and wild animals frequenting these mountain areas.
National and International Comparisons of Gynecological Research in Germany Based on a Bibliometric Analysis of Publications
Authors: Häussler Bertram , Schmalfeldt Barbara , Häussler Senta , Köninger Angela , Loos Stefan , Naumann Gert , Scharl Anton , Thaler Christian J. , Weiss Martin , Albrecht Martin 
Published: April 2024

AbstractRecent years have seen a considerable shift from male doctors to female doctors in the field of gynecology. Female doctors are traditionally more involved with planning and maintaining their family. For gynecology, this could be associated with a risk that research activities will decrease, particularly if results are published in scientific journals.In view of this shift, a comparative observational study was carried for 2022 in which 1306 publications were matched to 1786 female and male doctors reported on the websites of the 44 locations of university gynecology departments in Germany. In addition, the volume of publications issued between 2014 and 2022 was compared for Germany, France, the United Kingdom, and the United States. In Germany, the volume of publications in Gynecology was additionally compared with the publication outputs of the specialties Urology and Trauma Surgery.Since 2014, the increase in the numbers of publications in the field of Gynecology in Germany was lower (225%) than that of the countries with which it was compared (238%/252%/260% for F/UK/USA). When Gynecology was compared with other medical specialties in Germany, the number of publications in Urology were found to have increased at a lower rate (196%) while the number of publications in the field of Trauma Surgery increased by more (286%) than that of Gynecology. At the start of 2023, the percentage of women who were working as doctors at the lowest hierarchical level (junior doctor) was 81%. The publication output per capita of female doctors working at lower levels in the medical hierarchy, i.e., working as junior doctors and senior physicians, was between 40% and 80% lower than that of male doctors working at the same level. However, female directors published as much as male directors did. In the lower hierarchy levels, men were up to 14% more likely to be without
an academic title. Predictors for more extensive publication activities by young female and male doctors include the extent and quality of publications by doctors in senior positions, the presence of a comprehensive cancer center or an institute for human genetics at the location where the young doctors were working, and joint publications with foreign authors.For the German Society of Gynecology and Obstetrics, the results suggest a number of approaches to promote young researchers. The support provided to young female doctors is especially important as this should help to retain them as junior researchers over the long term.
Flexed position of the wrist in the cast reliably prevents
displacement after physeal Salter-Harris I and II distal radius
fractures
Authors: Kralj Rok , Kurtanjek Mario , Gržan Ivan Silvije , Bumči Igor , Višnjić Stjepan , Žic Rado 
Published: April 2024

Abstract
Background Salter-Harris I and II fractures of the distal radius are
common injuries. In our facility, immobilisation is performed in a way that
counteracts angulation forces. The aim of our study was to determine whether
there are significant differences between patients with and patients without a
loss of reduction treated with this method and to determine what degree of
flexion reliably prevents secondary displacement.
Patients and methods We conducted a retrospective study of 112 patients
(mean age: 12 years) who had sustained a Salter-Harris type I or II fracture of
the distal radius and were treated with reduction. Patients were grouped
according to fracture type and whether they sustained a loss of reduction or
not. Patients were compared for gender, age, initial angulation, angulation
after reduction, degree of flexion/extension of the wrist in the cast, residual
angulation, duration of immobilisation, and complication rate. We also analysed
whether a 45-degree flexed position of the wrist in plaster provides reliable
protection against secondary displacement.
Results In group I, patients with no loss of reduction had a significantly
greater degree of wrist flexion in the cast, a significantly shorter duration of
immobilisation and significantly less residual angulation. Patients with an
apex-volar deformity with the wrist immobilised at more than 45 degrees of
flexion had no loss of reduction at all and had significantly less residual
angulation compared with patients with the wrist immobilised at less than 45
degrees of flexion. In this patient group, loss of reduction was noted in 28% of
cases. The patients in group II with loss of reduction showed a significantly
higher angulation after the reduction. During the follow-up examination, one
patient experienced physeal arrest followed by an ulnar impaction syndrome.
Other complications recorded were minor.
Conclusions In summary, based on our results, we recommend that all
physeal fractures of the distal radius with an apex-volar angulation can be
safely treated with reduction and immobilisation counteracting the forces of
angulation. For apex-dorsal fractures, palmar flexion of 45° allows for reliable
reduction.
Psychische Störungen in der ICD-11
Authors: Walter Henrik , Husemann Ronja , Hölzel Lars P. 
Published: April 2024

ZUSAMMENFASSUNGDas internationale Klassifikationssystem für Krankheiten und verwandte Gesundheitsprobleme wurde in seiner 11. Überarbeitung am 1.1.2022 verabschiedet. Bis die ICD-11 verbindlich in der Versorgungspraxis gilt, wird es noch eine bislang nicht festgelegte Zeit dauern. In der ICD-11 werden auf Basis des aktuellen Forschungsstandes grundlegende und spannende Änderungen vorgenommen, die bereits heute Studium und Weiterbildung in den relevanten Disziplinen prägen. Die psychischen Störungen werden in der ICD-11 im Kapitel „06 Psychische Störungen, Verhaltensstörungen oder neuronale Entwicklungsstörungen“ beschrieben. Das Kapitel umfasst 23 Kategorien und enthält eine Reihe neuer Diagnosen, einzelne Störungen entfallen bzw. werden in anderen Kapiteln des ICD-11 klassifiziert. Im Vergleich zur ICD-10 ergeben sich durch die Revision teils bedeutsame Veränderungen für die Diagnostik und damit auch für die Behandlung psychischer Erkrankungen.
Atopische Keratokonjunktivitis: Pathophysiologie, Klinik und potenzielle neue Therapiekonzepte
Authors: Lapp Thabo , Mann Caroline , Jakob Thilo , Reinhard Thomas , Maier Philip Christian 
Published: April 2024

ZusammenfassungDie atopische Dermatitis (AD) ist eine chronisch rezidivierende inflammatorische Hauterkrankung, die mit einer 2-gipfligen Altersverteilung sowohl im Kindes- und Jugendalter als auch im mittleren Erwachsenenalter auftritt. In bis zu 50% der AD-Patient*innen findet sich eine Augenbeteiligung, die potenziell visusbedrohend verlaufen kann. Klinisch zeigt sich in der Mehrzahl der Fälle eine atopische Blepharo(kerato)konjunktivitis (ABK) bzw. atopische Keratokonjunktivitis (engl. AKC); weitere klinische Varianten aus diesem Formenkreis der entzündlichen Augenoberflächenerkrankungen sind die Keratoconjunctivitis vernalis im Kindes- bzw. Jugendalter und die allergische Konjunktivitis. Neben der bereits erwähnten Blepharitis, Keratitis und Konjunktivitis sind bei der AD auch eine Lidbeteiligung mit konsekutiver Lidfehlstellung, einer Limbusinsuffizienz mit Ausbildung von Pseudopterygien, eine vernarbende Konjunktivitis mit Symblephara und Fornixverkürzung sowie Malignome der
Augenoberfläche wie konjunktivale intraepitheliale Neoplasien (CIN) und Plattenepithelkarzinome beschrieben. Zudem ist für den Keratokonus eine Assoziation mit der AD bzw. der AKC beschrieben. Während sich die Therapie der AD in der Dermatologie durch den Einsatz von Biologika in den letzten Jahren revolutionär weiterentwickelt hat, erfolgt der primäre Einsatz dieser Biologika bei ophthalmologischen Komplikationen noch sehr zurückhaltend. Die Behandlung erfolgt hier häufig mit Steroiden und Calcineurin-Inhibitoren in topischer Form. Der folgende Artikel fasst neuere Entwicklungen aus der dermatologischen Grundlagenforschung und der klinischen Forschung zusammen und beleuchtet diese im Kontext aktueller ophthalmologischer Therapiekonzepte.
Bedeutung von Magnesium im Gehirnstoffwechsel
Authors: Kisters Sophia , Gröber Uwe , Kisters Klaus 
Published: April 2024

ZusammenfassungJüngste Forschungen lassen auf die Wichtigkeit eines intakten Magnesiumhaushalts
bei Vorliegen einer Demenz oder von Störungen im zentralen Nervensystem
schließen. Die pathophysiologische Bedeutung von Magnesium muss daher aufgrund
seiner guten Wirksamkeit weiter untersucht und weitere Erhebungen sollten im
Sinne der Betroffenen forciert werden. In jedem Fall gilt es,
Magnesiummangelzustände bei Risikopatienten zu vermeiden, um fortwährenden
Einschränkungen vorzubeugen. Trotz einiger Studien zum Einsatz von Magnesium bei
Demenz liegen heute jedoch nur wenige Erhebungen zur Wirkweise des Mineralstoffs
bei dieser Erkrankung vor. Bei vaskulärer Demenz sind eine gute
Blutdruckeinstellung und Senkung erhöhter Interleukin-6-Spiegel von großer
Bedeutung. Dies wird durch eine Magnesiumtherapie erreicht.