bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic singing-induced swallowing exercise for dysphagia in advanced-stage Parkinson’s disease
Authors: Yeo Myung Sun , Hwang Jihye , Lee Hye Kyoung , Kim Soo Ji , Cho Sung-Rae 
Published: April 2024

BackgroundWith longer life spans and medical advancements, the rising number of patients with advanced-stage Parkinson’s disease (PD) warrants attention. Current literature predominantly addresses dementia and fall management in these patients. However, exploring the impact of swallowing function on patients with advanced PD is crucial. Previous research has demonstrated notable enhancements in the quality of life related to voice for participants following a group singing-intervention program. To further elucidate the effect of individual singing-induced swallowing exercises, our study aimed to investigate the quantitative and qualitative effects of therapeutic singing on swallowing function in patients with advanced PD in comparison to a matched usual care control group. The hypothesis of this study is that therapeutic singing-induced swallowing exercises can assist to maintain swallowing function in patients with advanced PD.MethodsThis prospective matched control study compared the effects of a 6-week therapeutic singing-based swallowing intervention on swallowing function and quality of life in patients with advanced PD. The intervention group received individual sessions with a music therapist and conventional individual physical therapy. The control group received the same standard physical therapy for 6 weeks without music intervention. The primary outcome measure was Video Fluoroscopic Dysphagia Scale (VDS).ResultsThe study revealed that the intervention group maintained swallowing function, whereas the control group experienced deterioration, indicating significant time-dependent changes in Penetration-Aspiration Scale (PAS), National Institutes of Health-Swallowing Safety Scale (NIH-SSS), and VDS. Analysis of PAS and NIH-SSS liquid food scores in both groups showed significant time effects. However, the intervention group exhibited no significant differences between the pre- and post-tests, indicating preservation of the swallowing function. VDS of liquid food indicated an interaction effect between time and group in the pharyngeal phase and total scores. The Swallowing-Quality of Life showed significant time-effect improvement in the intervention group.ConclusionTherapeutic singing exercises may help maintain swallowing function in advanced PD patients, potentially enhancing quality of life related to swallowing in those with advanced-stage diseases.Clinical trial registrationhttps://cris.nih.go.kr/cris/search/listDetail.do, identifier KCT0008644.
The stratified effects of repetitive transcranial magnetic stimulation in upper limb motor impairment recovery after stroke: a meta-analysis
Authors: Li Ran , Liu Sihan , Li Tianyuan , Yang Kun , Wang Xue , Wang Wenjiao 
Published: April 2024

BackgroundThe recovery of upper extremity motor impairment after stroke remains a challenging task. The clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS), which is believed to aid in the recovery process, is still uncertain.MethodsA systematic search was conducted in Medline (Ovid), Cochrane and Embase electronic databases from March 28, 2014, to March 28, 2023. The inclusion criteria consisted of randomized controlled trials that assessed the effects of rTMS on the recovery of upper limb motor impairment among stroke patients. Various measurements, including the Fugl Meyer Assessment Upper Extremity Scale (FMA-UE), Brunnstrom recovery stage, Action Research Arm Test (ARAT), and Barthel index, were evaluated both before and after the intervention.ResultsNineteen articles with 865 patients were included. When considering only the rTMS parameters, both inhibitory and excitatory rTMS improved FMA-UE (MD = 1.87, 95% CI = [0.88]–[2.86], p &lt; 0.001) and Barthel index (MD = 9.73, 95% CI = [4.57]–[14.89], p &lt; 0.001). When considering only the severity of upper limb hemiplegia, both less severe (MD = 1.56, 95% CI = [0.64]–[2.49], p &lt; 0.001) and severe (MD = 2.05, 95% CI = [1.09]–[3.00], p &lt; 0.001) hemiplegia benefited from rTMS based on FMA-UE. However, when considering the rTMS parameters, severity of hemiplegia and stroke stages simultaneously, inhibitory rTMS was found to be significantly effective for less severe hemiplegia in the acute and subacute phases (MD = 4.55, 95% CI = [2.49]–[6.60], p &lt; 0.001), but not in the chronic phase based on FMA-UE. For severe hemiplegia, inhibitory rTMS was not significantly effective in the acute and subacute phases, but significantly effective in the chronic phase (MD = 2.10, 95% CI = [0.75]–[3.45], p = 0.002) based on FMA-UE. Excitatory rTMS was found to be significantly effective for less severe hemiplegia in the acute and subacute phases (MD = 1.93, 95% CI = [0.58]–[3.28], p = 0.005) based on FMA-UE. The improvements in Brunnstrom recovery stage and ARAT need further research.ConclusionThe effectiveness of rTMS depends on its parameters, severity of hemiplegia, and stroke stages. It is important to consider all these factors together, as any single grouping method is incomplete.
Clinical significance of miR-9-5p in NSCLC and its relationship with smoking
Authors: Zhang Tian-Xiang , Duan Xin-Chun , Cui Yong , Zhang Ye , Gu Meng , Wang Zi-Yu , Li Wei-Ying 
Published: April 2024

PurposeDysregulated expression of microRNA (miRNAs) in lung cancer has been wildly reported. The clinicopathologic significance of miR-9-5p in non-small-cell lung cancer (NSCLC) patients and its effect on NSCLC progression were explored in this study.Patients and methodsA total of 76 NSCLC patients were included. miR-9-5p expression was evaluated by real-time quantitative polymerase chain reaction (RT-qPCR). Then, in vitro experiments including cell growth curve assays, colony formation assays, and transwell migration assays were performed. Further clinicopathological and prognostic values were explored using bioinformatics analysis of the TCGA database.ResultsmiR-9-5p expression was significantly increased in tumor tissues (both P &lt; 0.0001). miR-9-5p expression was relatively higher in larger tumors (P = 0.0327) and in lung squamous carcinoma (LUSC) (P = 0. 0143). In addition, miR-9-5p was significantly upregulated in the normal lung tissues of cigarette smokers (P = 0.0099). In vitro, miR-9-5p was correlated with cell proliferation and migration. After that, bioinformatics analysis of the TCGA database indicated that miR-9-5p was correlated with tumor size (P = 0.0022), lymphatic metastasis (P = 0.0141), LUSC (P &lt; 0.0001), and smoking history (P &lt; 0.0001). Finally, a prognostic study indicated high miR-9-5p expression was correlated with poor prognosis in LUAD (P = 0.0121).ConclusionUpregulation of miR-9-5p may have an oncogenic effect in NSCLC and may be related to smoking. The conclusion of this study may help find new prognostic and therapeutic targets for NSCLC and the exploration of the relationship between smoking and lung cancer.
Pharmacokinetics of desflurane uptake and disposition in piglets
Authors: Lu Chih-Cherng , Ho Shung-Tai , Hu Oliver Yao-Pu , Hsiong Cheng-Huei , Cheng Yuan-Chen , Hsu Che-Hao , Lin Tso-Chou 
Published: April 2024

Introduction:Many respiratory but few arterial blood pharmacokinetics of desflurane uptake and disposition have been investigated. We explored the pharmacokinetic parameters in piglets by comparing inspiratory, end-tidal, arterial blood, and mixed venous blood concentrations of desflurane.Methods:Seven piglets were administered inspiratory 6% desflurane by inhalation over 2 h, followed by a 2-h disposition phase. Inspiratory and end-tidal concentrations were detected using an infrared analyzer. Femoral arterial blood and pulmonary artery mixed venous blood were sampled to determine desflurane concentrations by gas chromatography at 1, 3, 5, 10, 20, 30, 40, 50, 60, 80, 100, and 120 min during each uptake and disposition phase. Respiratory and hemodynamic parameters were measured simultaneously. Body uptake and disposition rates were calculated by multiplying the difference between the arterial and pulmonary artery blood concentrations by the cardiac output.Results:The rates of desflurane body uptake increased considerably in the initial 5 min (79.8 ml.min−1) and then declined slowly until 120 min (27.0 ml.min−1). Similar characteristics of washout were noted during the subsequent disposition phase. Concentration–time curves of end-tidal, arterial, and pulmonary artery blood concentrations fitted well to zero-order input and first-order disposition kinetics. Arterial and pulmonary artery blood concentrations were best fitted using a two-compartment model. After 2 h, only 21.9% of the desflurane administered had been eliminated from the body.Conclusion:Under a fixed inspiratory concentration, desflurane body uptake in piglets corresponded to constant zero-order infusion, and the 2-h disposition pattern followed first-order kinetics and best fitted to a two-compartment model.
Activating values intervention: an integrative pathway to well-being
Authors: Russo-Netzer Pninit , Atad Ofer Israel 
Published: April 2024

IntroductionThe present study expands the existing knowledge base regarding positive psychology interventions (PPIs), by employing an integrative approach to explore the potential benefits of translating values into action.MethodsParticipants (n = 476) were randomly assigned to the Activating Values intervention, the affirmation-only, or the control (no treatment) group. The intervention involved participants choosing a life area they valued, affirming its importance, identifying a specific action related to that valued area, and then planning and carrying out that chosen action within the following week. Data was collected at baseline and three follow-up points: one, two, and three weeks after the intervention.ResultsResults suggest that the intervention contributes to the participants’ well-being, including increased self-insight, sense of coherence, and prioritizing meaning, and decreased symptoms of psychopathology. Exploratory content analyses provide a deeper understanding of the content and frequency of activities chosen and the enabling conditions.DiscussionThe discussion explores the findings within this intersection as well as ramifications for brief, scalable interventions to support and promote well-being.
Impact of acute and chronic exposure to sulfamethoxazole on the kinetics and microbial structure of an activated sludge community
Authors: Pala-Ozkok Ilke , Katipoglu-Yazan Tugce , Olmez-Hanci Tugba , Jonas Daniel , Ubay-Cokgor Emine , Orhon Derin 
Published: April 2024

The aim of this study was to reveal the microbial and kinetic impacts of acute and chronic exposure to one of the frequently administered antibiotics, i.e., sulfamethoxazole, on an activated sludge biomass. Respirometric analysis and model evaluation of the oxygen utilization rate profiles were the backbone of this study. The results showed that continuous exposure to sulfamethoxazole resulted in the inhibition of substrate storage and an increase in the endogenous decay rates by twofold, which was supported by analysis of the resistance genes. A mild inhibition on the growth and hydrolysis kinetics was also observed. Moreover, sulfamethoxazole had a binding impact with available organic carbon, resulting in a slightly less oxygen consumption. DNA sequencing and antibiotic resistance gene analyses showed that continuous exposure to sulfamethoxazole caused a change in the community structure at the species level. Resistant bacteria including Arthrobacter sp. and members of the Chitinophagaceae and Intrasporangiaceae families were found to have dominated the bacterial community. The impact of intermittent exposure was also investigated, and the results indicated a drop in the severity of the impact after 20 days of intermittence.
Clinical progression of parotid salivary gland sialadenosis based on the selected <i>H. pylori</i> eradication therapy
Authors: Konovalova Т. А. , Kozlova M. V. , Chorbinskaya S. A. , Purveeva K. V. 
Published: April 2024

Relevance. In approximately 50.82% of instances, sialadenosis of the parotid salivary gland (PSG) emerges as a sequel to gastrointestinal (GI) disorders. This condition is characterized by diminished saliva production (hyposalivation) and enlargement (hypertrophy) of the gland. In Russia, the prevalence of GI diseases linked to acid-related issues and H. pylori infection (HP) is notably high. The therapeutic approach to this pathology focuses on the eradication of HP, employing various treatment strategies that incorporate the use of a proton pump inhibitor (PPI). The efficacy of PPIs hinges on their ability to inhibit the proton pump, which is situated in the endothelial lining of the smooth muscle vessels, including those that encase the acinar cells of the PSG. An essential aspect of parotid secretion is its protective role, which is executed through the production of secretory immunoglobulin A (sIgA) within the gland's ductal system. Therefore, exploring the clinical progression of PSG sialadenosis under eradication therapy regimens holds substantial significance.Materials and methods. Between 2021 and 2023, 80 patients with parotid salivary gland (PSG) sialadenosis and Helicobacter pylori stomach infection were studied. They were divided into treatment groups: Group I (25 patients, aged 45.81 ± 6.39 years) received quadruple therapy (standard-dose PPI, amoxicillin 1,000 mg, clarithromycin 500 mg twice daily, and bismuthate tripotassium dicitrate 120 mg four times daily); Group II (55 patients, aged 47.79 ± 7.15 years) underwent standard triple therapy (double-dose PPI, amoxicillin 1,000 mg, and clarithromycin 500 mg twice daily). A control group consisted of 20 nearly healthy individuals (average age 26.46 ± 4.12 years). All subjects underwent comprehensive dental and PSG assessments, including questionnaires, sialometry, and measurement of (sIgA) levels in parotid secretion.Results. After eradication therapy, Group I patients treated with quadruple therapy exhibited a 1.2-fold reduction in PSG secretory function (p = 0.048) and a 1.2-fold decrease in sIgA concentration (p = 0.035) compared to initial levels. Group II patients receiving triple therapy demonstrated a significant 3.6-fold decline in PSG sialometry parameters (p = 0.002) and a 1.8-fold reduction in sIgA levels (p = 0.006) by the 14th day post-eradication, relative to pre-treatment figures. Conclusion. Therefore, patients with GI acid-related conditions linked to HP infection should be evaluated by a dentist for potential PSG sialadenosis. The presence of PSG sialadenosis in individuals with HP stomach infection warrants consideration in the selection and administration of eradication therapy.
The impact of leadership style in team-based primary care – staff satisfaction and motivation
Authors: Bhatti Sara , Bale Stephanie , Gul Sehar , Muldoon Laura , Rayner Jennifer 
Published: April 2024

Background
Leadership styles, beliefs, and behaviours are an important and critical component to the delivery of quality care in any primary care organisation. The human resource crisis in health care has resulted in greater investments in team-based care; however, some leaders may not have experience working in team-based settings.

Aim
To explore what leadership characteristics, styles, and behaviours were most conducive to employee satisfaction, motivation, and delivery of care in a team-based primary care setting.

Design & setting
A qualitative study involving 16 community health centre (CHC) staff from six CHCs across Ontario, Canada.

Method
Thematic analysis of qualitative interviews using a framework based on transformational leadership (TL) theory.

Results
The following three themes emerged from our findings as having a noticeable impact on staff motivation, morale, delivery of care, and client outcomes: transparent and open communication; opportunities to collaborate in decision making; and staff recognition and appreciation. The results of our study indicate it is critical that leaders adopt leadership styles and approaches in which every team member is informed, heard, and appreciated.

Conclusion
This study described the leadership styles and characteristics that lead to improved employee satisfaction, motivation, and morale in a team-based primary care setting, and the impact this could and does have on quality and delivery of care. Future research is needed to better understand the impact of leadership in a variety of roles within a team-based environment, specifically in a multidisciplinary setting.
Bioequivalence of zolpidem hemitartrate: new formulations of 5 mg SL, 10 mg and 12.5 mg XR and comparison of their bioavailabilities
Authors: Aihara Camila Kaori , Guimarães Camila Leles , Rezende Vinicius Marcondes , Sverdloff Carlos Eduardo , Sessa Renata Gebara de Grande Di , Monaco Thiago de Oliveira , Bellorio Karini Bruno , Vêncio Sérgio Alberto Cunha 
Published: April 2024

Objective: To evaluate pharmaceutical bioequivalence between two formulations of 5 mg zolpidem hemitartrate sublingual and, 10 and 12.5 mg extended-release formulations tablets in healthy subjects under fasting and fed conditions. Methods: An open label, monocentric, randomized, 2 x 2 crossover study in 40 healthy adults under fasting conditions comparing two formulations of zolpidem 5mg sublingual tablets. Analyte concentrations in human plasma were determined using a validated liquid chromatography with a tandem mass spectrometer detector method (LC-MS/MS). The same design was utilized to evaluate the other formulations.
Results: Statistical analysis has determined geometric mean of test / reference ratio, confidence intervals, and power of the test to the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞. The geometric mean ratio (90%CI) of the test drug/reference drug for zolpidem 5mg were 99.89 to 113.57% for Cmax, 97.15% to 108.40% for AUC0-t, and 97.22% to 108.13% for AUC0-∞. Power of the test was 99.35% for Cmax and 100% AUC0-t, and AUC0-∞. Conclusion: Both test and reference are bioequivalent for all formulations and, therefore, they are interchangeable, according to the Brazilian criteria (Anvisa resolution RE nº 1170/2006), since confidence intervals for Cmax and AUC0-t ratios were within 80% and 125%.
Influência dos aspectos biopsicossociais na dor, funcionalidade e qualidade de vida de pacientes e cuidadores de um hospital da rede pública do Recife
Authors: Soares Meyrian Luana Teles de Sousa Luz , Nascimento Carina Alves do , Costa Marinete Júlia de Mendonça , Silva Ozielson Gomes da 
Published: April 2024

Os aspectos psicossociais na dor persistente, principalmente em cervicalgias e lombalgias, têm sido descritos como fatores que precipitam as dores, contribuem para a sua cronificação, além de gerar incapacidade física. O monitoramento e o diagnóstico precoce contribui para minimizar possíveis complicações e alterações na qualidade de vida desses indivíduos. Avaliar os aspectos biopsicossociais em pacientes e cuidadores em um serviço de referência da rede pública de Recife – PE. O estudo foi quantitativo, do tipo transversal descritivo. A amostra foi composta por indivíduos internados e seus cuidadores admitidos na enfermaria adulto de um hospital de referência. Após assinatura do termo de concordância, realizaram uma avaliação inicial para coleta de dados antropométricos e sóciodemográficos, bem como foram submetidos a aplicação dos questionários cinético-funcionais FABQ, Escala de Tampa e SF12. Os dados foram coletados e expostos em tabelas e gráficos do Microsoft Excel 2010, utilizando medidas de tendência central e proporção, sendo considerados significativos quando inferiores a 5%. 41 cuidadores (68,33%) e 19 pacientes (31,67%), cuja média das medidas antropométricas foram peso, altura, IMC e idade, respectivamente, de 73,92 (±5.86), 1,65 (±0.88)m, 27.41 (± 4.74) e 40,7 (± 8.15) anos. Entre as principais queixas dos cuidadores, 37,67% corresponderam a lombalgia, já entre os pacientes 89,47% estavam associadas a síndrome do imobilismo. A média dos participantes em relação aos questionários utilizados considerando SF- 12 Físico, SF-12 Mental, Escala TAMPA, FAB-Q (Atividade física), FABQ (Trabalho) e FABQ (Total) foi de 41.04; 42.56; 42.48; 11.73; 22.30 e 34.0, respectivamente. A média do resultado da Escala TAMPA para cinesiofobia dos cuidadores subdividido por dias, considerando 1 a 2 dias; 3 a 4 dias; 5 a 9 dias; 10 a 30 dias e tempo superior a 3 meses, foi de 38.26; 38.0; 41.12; 36.80 e 47.0, respectivamente. Já o resultado do grupo dos pacientes foi de, respectivamente: 45.85; 53.75; 48.0 e 52.33. Os fatores biopsicossociais apresentaram influência na dor, funcionalidade e qualidade de vida entre os pacientes e cuidadores avaliados no respectivo serviço da rede pública.
Movimento CoopEducação: fomento da cultura cooperativista, empreendedora e financeira em escolas
Authors: Oliveira Desley Raul Alves , Oliveira Ighor Thadeu Silva 
Published: April 2024

O Movimento CoopEducação é o programa educacional do Sicoob Sarom que se apresenta como uma proposta de ensino-aprendizagem, onde as escolas participantes do programa têm a oportunidade de contribuir para o desenvolvimento dos eixos da educação cooperativista, empreendedora e financeira em sua prática pedagógica, transformando o ambiente escolar em um espaço propício para o desenvolvimento de habilidades e competências que serão úteis ao longo de toda a vida adulta.
Baseado nos princípios e valores do cooperativismo, esse programa prepara os estudantes para que sejam capazes de assimilar as teorias e os conceitos abordados nas disciplinas em sala de aula e posteriormente aplicá-los no seu cotidiano, desenvolvendo assim, habilidades e competências do comportamento empreendedor, financeiro e da cultura da cooperação.
Neste relato de experiência, apresentaremos como a cooperação pode ser uma alternativa para enfrentar os desafios socioeconômicos, construir relações mais justas e solidárias e criar condições para um ambiente mais saudável e produtivo para todos.