bluuebunny/crossref_metadata_2025_split huggingface dataset:
Citizens’ Sentiments or Governmental Rationales? Post-War Reconstruction of Bombed Cities in the Netherlands
Authors: van Meurs Wim , Brinkhorst Laura , Oprel Marieke 
Published: April 2024

Abstract
After large-scale destruction by acts of war or natural disasters, reconstruction of housing and infrastructure is up to the state. Typically, reconstruction is preceded by expropriation of real estate ‘in the public interest’. Because of the bombing of Dutch cities and the demolition of entire districts for the Atlantikwall, the Dutch government deployed this instrument after liberation. Thanks to the institution of the Ledger for Reconstruction, cities like Rotterdam and Arnhem were rebuilt. Yet, the Ledger was not invented in 1945 or in London, but in 1940 under German occupation, for Rotterdam. Given the large number of expropriated Dutch citizens and the huge sums involved, historians’ attention for these expropriations has been remarkably scarce. Mostly, they focus on reconstruction as net result and convey a message of national unity, progress and hope – the very message that was conveyed during those post-war years. This contribution therefore brings to the fore resistance and resentment as responses to the government’s heavy-handed policies of expropriation and reconstruction. And questions whether adopting an institution from the occupation period went uncontested after liberation.
Musings on Literary History Research: The Cambridge History of Chinese Literature as a Case Study
Authors: Xu Zhixiao 
Published: April 2024

Abstract
In the study of literary history, how can we transcend the traditional models found in existing works? How can we take literary history research in new directions? For scholars of literary history who aspire to break new ground in the field, these are questions that must be properly considered. Published outside of China, The Cambridge History of Chinese Literature offers us a paradigm for literary history writing. While some of its features might be debatable, it offers much inspiration and food for thought. In this case study, the author shares with our readers some of his insights and opinions regarding the study of literary history.
Land-Use Feedback under Global Warming—A Transition from Radiative to Hydrological Feedback Regime
Authors: Singh Arshdeep , Kumar Sanjiv , Chen Liang , Maruf Montasir , Lawrence Peter , Lo Min-Hui 
Published: April 2024

Abstract
This study examines the effects of land-use (LU) change on regional climate, comparing historical and future scenarios using seven climate models from phase 6 of Coupled Model Intercomparison Project–Land Use Model Intercomparison Project experiments. LU changes are evaluated relative to land-use conditions during the preindustrial climate. Using the Community Earth System Model, version 2–Large Ensemble (CESM2-LE) experiment, we distinguish LU impacts from natural climate variability. We assess LU impact locally by comparing the impacts of climate change in neighboring areas with and without LU changes. Further, we conduct CESM2 experiments with and without LU changes to investigate LU-related climate processes. A multimodel analysis reveals a shift in LU-induced climate impacts, from cooling in the past to warming in the future climate across midlatitude regions. For instance, in North America, LU’s effect on air temperature changes from −0.24° ± 0.18°C historically to 0.62° ± 0.27°C in the future during the boreal summer. The CESM2-LE shows a decrease in LU-driven cooling from −0.92° ± 0.09°C in the past to −0.09° ± 0.09°C in future boreal summers in North America. A hydroclimatic perspective linking LU and climate feedback indicates LU changes causing soil moisture drying in the midlatitude regions. This contrasts with hydrology-only views showing wetter soil conditions due to LU changes. Furthermore, global warming causes widespread drying of soil moisture across various regions. Midlatitude regions shift from a historically wet regime to a water-limited transitional regime in the future climate. This results in reduced evapotranspiration, weakening LU-driven cooling in future climate projections. A strong linear relationship exists between soil moisture and evaporative fraction in midlatitudes.

Significance Statement
Land–atmosphere feedback involving soil moisture can increase local temperature and affect how land-use (LU) change impacts manifest in a warming climate. Conversely, an increased surface reflectance due to LU change can decrease local temperature in the midlatitude regions. Further, the LU change signal is often mixed with the internal climate variability, making it harder to separate. This study uses a novel technique to separate LU change impact from other climate forcing in the latest generation of climate and Earth system models. In the future climate, soil moisture drying lessens the cooling impact. A large-ensemble climate experiment analysis confirms a significant weakening of the LU-driven cooling impact in the midlatitudes. Both LU and climate changes exacerbate soil moisture drying, leading to a shift toward a water-limited system where hydrological feedback becomes more influential than radiative feedback.
Anticipation by redress: Transforming African mega-infrastructure futures
Authors: Cupers Kenny 
Published: April 2024

Critical scholarship has interpreted ongoing mega-projects of infrastructural expansion in Africa through the lens of colonialism. Deepening this scholarship, the article questions analytical models of global coloniality or colonial continuity. To avoid reductive accounts of the ways individuals and collectives engage mega-infrastructure projects, the article proposes an alternative model of historically informed analysis, more attentive to the contingent refractions of colonial relations in geographies of insurgency, dispossession, and racialization. In particular, the article analyzes how inheritances of the Kenyatta era (1963–1978) inform communities’ engagement with Kenya’s ongoing Lamu Port–South Sudan–Ethiopia Transport (LAPSSET) development corridor project. This analysis shows how the promise of infrastructure-led development reactivates violent histories of displacement and forced resettlement. These histories orient collective efforts to transform state-sanctioned infrastructural futures, framing anticipation as a mode of redress. Closer attention to the ways in which historical experience shapes collective subjectivity and everyday agency, the article concludes, will allow scholars to develop more situated and more accountable analyses of the coloniality of infrastructure. Abstract (Kiswahili):Usomi muhimu umefasiri miradi mikubwa inayoendelea ya upanuzi wa miundombinu barani Afrika kupitia lenzi ya ukoloni. Kukuza na kuthibitisha usomi huu, karatasi inahoji mifano ya uchanganuzi ya ukoloni wa kimataifa au mwendelezo wa ukoloni. Ili kuepuka akaunti za kupunguza jinsi ambavyo watu binafsi na vikundi hushiriki miradi mikubwa ya miundombinu, karatasi inapendekeza mtindo mbadala wa uchanganuzi wenye taarifa za kihistoria, makini zaidi kwa miondoko ya kawaida ya uhusiano wa kikoloni katika jiografia ya uasi, unyang'anyi na ubaguzi wa rangi. Hasa, jarida hilo linachanganua jinsi urithi wa enzi ya Kenyatta (1963-1978) unavyofahamisha ushirikiano wa jamii na mradi wa ukanda wa maendeleo wa Kenya wa Bandari ya Lamu–Sudan Kusini–Ethiopia Transport (LAPSSET). Uchambuzi huu unaonyesha jinsi ahadi ya maendeleo inayoongozwa na miundombinu inavyowezesha upya historia za vurugu za watu kuhama na kulazimishwa kupata makazi mapya. Historia hizi huelekeza juhudi za pamoja za kubadilisha hali ya baadaye ya miundombinu iliyoidhinishwa na serikali, na kutunga matarajio kama njia ya kurekebisha. Uangalifu wa karibu zaidi wa njia ambazo uzoefu wa kihistoria unaunda utii wa pamoja na wakala wa kila siku, karatasi inahitimisha, itaruhusu wasomi kukuza uchanganuzi uliowekwa zaidi na wa kuwajibika zaidi wa ukoloni wa miundombinu.
Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis
Authors: Piszczatowski Richard T. , Bülow Hannes E. , Steidl Ulrich 
Published: April 2024

Abstract
From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology. In this review, we provide an overview of the importance of HS and the proteoglycans (HSPGs) to which they are attached within the major cellular subtypes of the hematopoietic system. We summarize the roles of HSPGs, HS, and HS modifications within each main hematopoietic cell lineage of both myeloid and lymphoid arms. Lastly, we discuss the biological advances in the detection of HS modifications and their potential to further discriminate cell types within hematopoietic tissue.
O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies
Authors: Karampini Ellie , Doherty Dearbhla , Bürgisser Petra E. , Garre Massimiliano , Schoen Ingmar , Elliott Stephanie , Bierings Ruben , O’Donnell James S. 
Published: April 2024

Abstract
von Willebrand factor (VWF) undergoes complex posttranslational modification within endothelial cells (ECs) before secretion. This includes significant N- and O-linked glycosylation. Previous studies have demonstrated that changes in N-linked glycan structures significantly influence VWF biosynthesis. In contrast, although abnormalities in VWF O-linked glycans (OLGs) have been associated with enhanced VWF clearance, their effect on VWF biosynthesis remains poorly explored. Herein, we report a novel role for OLG determinants in regulating VWF biosynthesis and trafficking within ECs. We demonstrate that alterations in OLGs (notably reduced terminal sialylation) lead to activation of the A1 domain of VWF within EC. In the presence of altered OLG, VWF multimerization is reduced and Weibel-Palade body (WPB) formation significantly impaired. Consistently, the amount of VWF secreted from WPB after EC activation was significantly reduced in the context of O-glycosylation inhibition. Finally, altered OLG on VWF not only reduced the amount of VWF secreted after EC activation but also affected its hemostatic efficacy. Notably, VWF secreted after WPB exocytosis consisted predominantly of low molecular weight multimers, and the length of tethered VWF string formation on the surface of activated ECs was significantly reduced. In conclusion, our data therefore support the hypothesis that alterations in O-glycosylation pathways directly affect VWF trafficking within human EC. These findings are interesting given that previous studies have reported altered OLG on plasma VWF (notably increased T-antigen expression) in patients with von Willebrand disease.
Estimates of primary ciliary dyskinesia prevalence: a scoping review
Authors: Wee Wallace B. , Gatt Dvir , Seidl Elias , Santyr Giles , To Teresa , Dell Sharon D. 
Published: April 2024

BackgroundPrimary ciliary dyskinesia (PCD) is a rare multisystem genetic disease caused by dysfunctional motile cilia. Despite PCD being the second most common inherited airway disease after cystic fibrosis, PCD continues to be under-recognised globally owing to nonspecific clinical features and the lack of a gold standard diagnostic test. Commonly repeated prevalence estimates range from one in 10 000 to one in 20 000, based on regional epidemiological studies with known limitations. The purpose of this scoping review was to appraise the PCD literature, to determine the best available global PCD prevalence estimate and to inform the reader about the potential unmet health service needs in PCD. The primary objective of the present study was to systematically review the literature about PCD prevalence estimates.MethodsA scoping review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) methodology. Included studies estimated PCD prevalence and used cohort, clinical or genomic data. Case reports, conference abstracts, review articles, animal studies or non-English articles were excluded.ResultsA literature review identified 3484 unique abstracts; 34 underwent full-text review and eight met the inclusion/exclusion criteria. Seven articles were based on epidemiological studies of specific geographical regions and provided prevalence estimates that ranged from approximately one to 44.1 in 100 000. Only one study estimated global prevalence, using two large genomic databases, and calculated it to be ∼13.2 in 100 000 (based on pathogenic variants in 29 disease-causing genes).ConclusionsA population-based genomic approach for estimating global prevalence has found that PCD is much more prevalent than previously cited in the literature. This highlights the potential unmet health service needs of people living with PCD.
F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
Authors: Cao Zhiqin , Zhang Keke , Liu Jingruo , Pan Yu , Shi Jiayi , Li Luxin , Sun Xiaocan , Li Shiqi , Yuan Xiaohuan , Wu Dan 
Published: April 2024

Abstract
Background
Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation. We previously constructed and prepared truncated LAP (tLAP), and confirmed that tLAP inhibited liver fibrosis by affecting TGF-β1. SPACE peptide has both transdermal and transmembrane functions. SPACE promotes the delivery of macromolecules through the stratum corneum into the dermis. This study aimed to alleviate skin fibrosis through the delivery of tLAP by SPACE.

Methods
The SPACE-tLAP (SE-tLAP) recombinant plasmid was constructed. SE-tLAP was purified by nickel affinity chromatography. The effects of SE-tLAP on the proliferation, migration, and expression of fibrosis-related and inflammatory factors were evaluated in TGF-β1-induced NIH-3T3 cells. F127-SE-tLAP hydrogel was constructed by using F127 as a carrier to load SE-tLAP polypeptide. The degradation, drug release, and biocompatibility of F127-SE-tLAP were evaluated. Bleomycin was used to induce skin fibrosis in mice. HE, Masson, and immunohistochemistry were used to observe the skin histological characteristics.

Results
SE-tLAP inhibited the proliferation, migration, and expression of fibrosis-related and inflammatory factors in NIH-3T3 cells. F127-SE-tLAP significantly reduced ECM production, collagen deposition, and fibrotic pathological changes, thereby alleviating skin fibrosis.

Conclusion
F127-SE-tLAP could increase the transdermal delivery of LAP, reduce the production and deposition of ECM, inhibit the formation of dermal collagen fibers, and alleviate the progression of skin fibrosis. It may provide a new idea for the therapy of skin fibrosis.
Identification of the principal neuropeptide MIP and its action pathway in larval settlement of the echiuran worm Urechis unicinctus
Authors: Yang Zhi , Zhang Long , Zhang Wenqing , Tian Xinhua , Lai Wenyuan , Lin Dawei , Feng Yuxin , Jiang Wenwen , Zhang Zhengrui , Zhang Zhifeng 
Published: April 2024

Abstract
Background
Larval settlement and metamorphosis represent critical events in the life history of marine benthic animals. Myoinhibitory peptide (MIP) plays a pivotal role in larval settlement of marine invertebrates. However, the molecular mechanisms of MIP involved in this process are not well understood.

Results
In this study, we evaluated the effects of thirteen MIP mature peptides on triggering the larval settlement of Urechis unicinctus (Xenopneusta, Urechidae), and determined that MIP2 was the principal neuropeptide. Transcriptomic analysis was employed to identify differentially expressed genes (DEGs) between the MIP2-treated larvae and normal early-segmentation larvae. Both cAMP and calcium signaling pathways were enriched in the DEGs of the MIP2-treated larvae, and two neuropeptide receptor genes (Spr, Fmrfar) were up-regulated in the MIP2-treated larvae. The activation of the SPR-cAMP pathway by MIP2 was experimentally validated in HEK293T cells. Furthermore, fourteen cilia-related genes, including Tctex1d2, Cfap45, Ift43, Ift74, Ift22, Cav1 and Mns1, etc. exhibited down-regulated expression in the MIP2-treated larvae. Whole-mount in situ hybridization identified two selected ciliary genes, Tctex1d2 and Cfap45, were specially expressed in circumoral ciliary cells of the early-segmentation larvae. Knocking down Tctex1d2 mRNA levels by in vivo RNA interference significantly increased the larval settlement rate.

Conclusion
Our findings suggest that MIP2 inhibits the function of the cilia-related genes, such as Tctex1d2, through the SPR-cAMP-PKA pathway, thereby inducing larval settlement in U. unicinctus. The study contributes important data to the understanding of neuropeptide regulation in larval settlement.
Green-fabricated silver nanoparticles from Quercus incana leaf extract to control the early blight of tomatoes caused by Alternaria solani
Authors: Khatoon Javaria , Mehmood Ansar , Khalid Abd ur Rehman , Khan Muhammad Abdul Rauf , Ahmad Khawaja Shafique , Amjad Muhammad Shoaib , Bashir Urooj , Raffi Muhammad , Proćków Jarosław 
Published: April 2024

Abstract
Background
Early blight (EB) of Tomatoes, caused by Alternaria solani, is a serious fungal disease that adversely affects tomato production. Infection is characterized by dark lesions on leaves, stems, and fruits. Several agrochemicals can be used to control infection, these chemicals may disrupt environmental equilibrium. An alternative technology is needed to address this significant fungal threat. This study was designed to control the growth of EB in tomatoes caused by A. solani, using green-fabricated silver nanoparticles (Ag-NPs).

Results
Ag-NPs were synthesized through an environmentally friendly and cost-effective approach using leaf extract of Quercus incana Roxb. (Fagaceae). The physico-chemical characterization of the Ag-NPs was conducted through UV-visible spectroscopy, scanning electron microscopy, X-ray diffraction analysis, and Fourier transform infrared spectrometry. The Ag-NPs produced were round with a mean diameter of 27 nm. The antifungal activity of these Ag-NPs was assessed through in vitro Petri plate and in vitro leaflet assays against A. solani. The green fabricated Ag-NPs exhibited excellent antifungal activity in vitro at a concentration of 100 mg/l against A. solani, inhibiting growth by 98.27 ± 1.58% and 92.79 ± 1.33% during Petri plate and leaflet assays, respectively.

Conclusion
In conclusion, this study suggests the practical application of green-fabricated Ag-NPs from Q. incana leaf extract against A. solani to effectively control EB disease in tomatoes.
Prevalence and associated risk factors of resistant hypertension among Chinese hypertensive patients in primary care setting
Authors: Chan Kilpatrick Kiupak , Chiang Lapkin , Choi Clarence Chuenming , Li Yimchu , Chen Catherine Xiarui 
Published: April 2024

Abstract
Introduction
Hypertension (HT) is a major public health problem globally, and it is the commonest chronic disease with a prevalence of 27% among people aged 15 years or above in Hong Kong. There is emerging literature confirmed that patients with resistant hypertension (RHT) give its increased risk for adverse clinical outcomes and higher rate of documented target organ damage. This study aims to identify the prevalence of RHT among Chinese hypertensive patients managed in public primary care setting of Hong Kong and exploring its associated risk factors.

Methodology
This is a cross-sectional descriptive study. Chinese hypertensive patients aged 30 or above with regular follow-up between 1st July 2019 and 30th June 2020 in 10 public primary care clinics under the Hospital Authority of Hong Kong were included. Demographic data, clinical parameters and drug profile of patients were retrieved from its computerized record system. The prevalence of RHT was identified and the associated risk factors of RHT were explored by multivariate logistic regression analysis.

Results
Among the 538 sampled Chinese hypertensive patients, the mean age was 67.4 ± 11.5 years old, and 51.9% were female. The mean duration of hypertension was 10.1 ± 6.4 years, with a mean systolic and diastolic blood pressure of 128.8 ± 12.3 and 72.9 ± 10.8 mmHg respectively. 40 out of 538 patients were found to have RHT, giving an overall prevalence of 7.43%. Four factors were found to be associated with increased risk of RHT, in ascending order of odds ratio: duration of hypertension (OR 1.08), male gender (OR 2.72), comorbid with type 2 diabetes mellitus (T2DM, OR 2.99), and congestive heart failure (CHF, OR 5.39).

Conclusion
The prevalence of RHT among Chinese hypertensive patients in primary care setting of Hong Kong is 7.43%. RHT is more common in male patients, patients with longer duration of hypertension, concomitant T2DM and CHF. Clinicians should be vigilant when managing these groups of patients and provide aggressive treatment and close monitoring.
Home care needs assessment among caregivers of children and adolescents with osteogenesis imperfecta: a cross-sectional study
Authors: Wang Xinyi , Li Yuqing , Zhong Yaping , Wang Min , Liu Xuehua , Han Wenxuan , Chen Huifang , Ji Ji 
Published: April 2024

Abstract
Background
Children and adolescents with complex medical issues need home care services; however, few studies have provided insight into the unmet home care needs of the families of patients with osteogenesis imperfecta (OI). In this study, we aimed to assess the home care needs of caregivers of children and adolescents with OI and the associated factors.

Methods
A self-administered questionnaire was administered online to 142 caregivers of patients with OI aged 3–17 years between May and October 2022 from 25 provinces in China. The questionnaire comprised 15 questions on demographic variables and 14 questions on home care needs. Chi-square analysis was used to compare group differences for categorical variables. Multivariate binary logistic regression analysis was conducted to examine predictors of caregivers’ home care needs.

Results
The study findings indicated that 81.5% of caregivers had high home care needs. The three leading types of home care needs were helping the child carry out physical fitness recovery exercises at home (72.5%), understanding precautions regarding treatment drugs (72.5%), and relieving the child’s pain (70.4%). OI patients’ poor self-care ability (adjusted odds ratio = 5.9, 95% confidence interval = 1.8–19.0) was related to caregivers’ high level of home care needs.

Conclusions
The findings of this study suggest that future scientific research and nursing guidance should focus on OI patients’ physical training, medication management, pain relief, fracture prevention, and treatment. In addition, caregivers of patients with poor self-care ability should receive special attention in the development of interventions. This study can help with addressing the unmet home care needs of caregivers of children and adolescents with OI. It is vital to develop a personalized intervention plan based on patients’ self-care ability.