bluuebunny/crossref_metadata_2025_split huggingface dataset:
The arthropathy of relapsing polychondritis
Authors: O'Hanlan Michael , McAdam Lawrence P. , Bluestone Rodney , Pearson Carl M. 
Published: February 2007

AbstractTwenty‐three adults (11 males and 12 females) with well‐defined relapsing polychondritis (RP) are studied in order to characterize the arthropathy of RP. Arthritis was found in 19 patients‐as the presenting feature in 8 and as a significant symptom in 11 others. The usual pattern of involvement was mitratory, asymmetric, nonnodular, nonerosive, and seronegative, and affected large and small joints as well as parasternal articulations. In addition RP was seen in 3 patients with preexisting chronic polyarthritis or associated rheumatic disease.
Deforming arthritis of the hands in polymyositis
Authors: Bunch Thomas W. , O'Duffy J. Desmond , McLeod Richard A. 
Published: February 2007

AbstractArthritis of the hands with erosions, periosteal calcification, and interphalangeal thumb joint instability was seen in 6 patients with polymyositis. “Overlap” features such as Raynaud's phenomenon, positive LE clot test, and positive antinuclear antibody test were present, but clinically the primary disease was clearly polymyositis. This rather unusual constellation of roentgenographic findings strongly suggests the possibility of polymyositis.
A pathogenetic model for erosive synovitis. Lessons from animal arthritides
Authors: Hadler Nortin M. 
Published: February 2007

AbstractAdjuvant arthritis, streptococcal cell wall—induced arthritis, and Erysipelothrix insidiosa arthritis are laboratory models of relapsing, erosive synovitis. A review of the experimental literature suggests that their pathogenesis is similar. The persistence in macrophages in the pannus of nonbiodegradable microbial cell wall components containing the peptidoglycan moeity is the central event. Based on this experimental literature, a model for the pathogenesis of these arthritides is developed. This model is testable and relevant to erosive synovitis in man.
Altered lymphocyte reactivity in rheumatoid arthritis
Authors: Arthur Silverman H. , Johnson John S. , Vaughan John H. , McGlamory James C. 
Published: February 2007

AbstractBlastogenic transformation of peripheral lymphocytes with phytohemagglutinin (PHA), conconavalin A (Con A), and pokeweed mitogen (PWM) was studied in 29 patients with rheumatoid arthritis (RA). The PHA response was depressed in a subgroup of RA patients with erosive disease. The Con A response was also depressed and paralleled the PHA response. The PWM response was not depressed. These results lend support to the hypothesis of a functional defect of cellular immunity in RA. It was shown that lymphocyte responsiveness to a single mitogen concentration is not an adequate assessment of the overall responsiveness of the lymphocytes tested.
Controlled trial of cyclophosphamide in rheumatoid arthritis
Authors: Townes Alexander S. , Sowa James M. , Shulman Lawrence E. 
Published: February 2007

AbstractTwenty‐four patients with severe progressive rheumatoid arthritis were randomly assigned to cyclo‐phosphamide or placebo in a double‐blind crossover trial. Eleven patients who completed 9 months on cyclophosphamide (average dose: 1.8 mg/kg/day) demonstrated significant decrease in painful joints, swollen joints, and morning stiffness and increase in grip strength when compared to 11 patients on placebo. After crossover, significant improvement was observed in patients switched to cyclophosphamide, and deterioration within 2 months was observed in most patients changed from drug to placebo. Serum immunoglobulins and rheumatoid factor titers decreased with cyclophosphamide but antibody response to Vi antigen was unaffected. Primary delayed immune response to 2,4‐dinitrochlorobenzene was markedly depressed. Adverse effects were troublesome—hemorrhagic cystitis affected 4 patients and amenorrhea occurred in 3. Despite its striking beneficial effect, cyclophosphamide should be prescribed cautiously and only in severe resistant cases of rheumatoid arthritis.
Fine structural analysis of rabbit synovial cells. II. Fine structure and rosette‐forming cells of explant and monolayer cultures
Authors: Krey Phoebe R. , Scheinberg Morton A. , Cohen Alan S. 
Published: February 2007

AbstractThe fine structure and plasma membrane receptors of explant and monolayer cells of normal rabbit synovium were studied. In explants about 10% of the cells were round and formed rosettes with IgG and C3 markers, whereas the remaining cells were stellate, resembled young fibroblasts, and had no receptors for IgG and complement. Monolayer cells looked like fibroblasts, produced fine extracellular fibrils and hyaluronate, and formed no rosettes. Thus early cultures contain both macrophages and fibroblasts but only the latter persist in monolayer.
Rheumatoid factor (antigammaglobulin) in women. Effects of oral contraceptive use on its prevalence
Authors: Sponzilli Ernest E. , Ramcharan Savitri , Wingerd John 
Published: February 2007

AbstractA total of 14,856 women, including 921 pregnant subjects, were tested for rheumatoid factor; 4,562 were using oral contraceptives at the time of testing. The prevalence of rheumatoid factor increased directly with age. The age‐adjusted prevalence of rheumatoid factor was lower in oral contraceptive users than in nonusers but this difference was not statistically significant. Rheumatoid factor remained positive in 39% of subjects undergoing retesting after an average interval of 16 months. Those women with higher titers of rheumatoid factor were more likely to remain positive (81%). Of the women having positive tests, 5.4% were identified as having rheumatoid disease.
Periarticular uptake of 99mtechnetium diphosphonate in psoriatics. Correlation with cutaneous activity
Authors: Namey Thomas C. , Rosenthall Leonard 
Published: February 2007

AbstractThe periarticular uptake of 99mtechnetium‐labeled diphosphonate (99mTcDP) was compared in 12 patients hospitalized for psoriasis and in 12 hospitalized for other dermatoses not associated with arthropathy. The 12 patients with psoriasis had recent onset disease of less than 5 years duration; neither group had historical or clinical evidence of arthritis. All psoriatics had markedly abnormal scans with symmetrically increased periarticular uptake about the imaged joints. None of the controls had similar findings. In 4 patients scanned with 99mtechnetium‐pertechnetate within 24 hours of their 99mTcDP scan, no evidence of inflammatory synovitis was found. Three of these patients were serially imaged with 99mTcDP at intervals of 2 weeks to 3 months after their initial study, when obvious clinical improvement in their psoriasis was apparent. Improvement in the radionuclide joint images was demonstrated in some of the patients, but none reverted to normal during the study period. In light of recent evidence for the preferential binding of 99mTcDP to immature collagen, it is suggested that psoriasis may represent a generalized, but uncharacterized, collagen disorder present in bone as well as skin, linking the cutaneous disease with the potential for arthropathy.
Characteristics of patients with serum antibodies to extractable nuclear antigens
Authors: Leibfarth James H. , Persellin Robert H. 
Published: February 2007

AbstractA distinguishing feature of the mixed connective tissue disease (MCTD) syndrome is the presence in the serum of antibody in high titer to ribonucleoprotein (RNP). To determine whether this was an exclusive observation, a large rheumatic disease population was surveyed for the presence of antibody in high titer to extractable nuclear antigens (ENA) including RNP. Of 650 sera examined, 440 (from 240 patients) had antinuclear antibody. Only 39 patients had serum antibody to ENA in titers ≧ 1:200 dilution. In 16 the anti‐ENA was shown by RNAse digestion to be anti‐RNP. Although many clinical and laboratory characteristics were similar in these two groups, the patients more closely resembled the previously described MCTD syndrome and, importantly, less often had severe renal and central nervous system disease manifestations. Thus the presence of serum antibodies to ENA that are predominantly RNAse‐sensitive (anti‐RNP) helps to identify a rheumatic disease syndrome and also appears to have prognostic value.
Antibodies to dAT detected by membrane filtration
Authors: Lentz Kenneth , Winfield John B. , Barland Peter 
Published: February 2007

AbstractSera from patients with active systemic lupus erythematosus caused the retention of the radioactively labeled synthetic polynucleotide 14C‐dAT on cellulose nitrate filters. The amount of 14C‐dAT bound correlated with the presence of hypocomplementemia and active renal disease. Sera containing only anti‐single‐stranded DNA antibodies did not bind 14C‐dAT but did bind 125I DNA from E coli that had been prefiltered to remove ssDNA contamination. Inhibition experiments also indicated the presence of antigenic differences between 14C‐dAT and prefiltered 125I‐E coli DNA. The data suggest that dAT carries one of the major antigenic specificities for antinative DNA antibodies in SLE, and that cellulose nitrate filtration fails to remove a significant proportion of contaminating single‐stranded DNA determinants in non‐synthetic DNA.
Aggregation of cartilage proteoglycans. Ii. Evidence for the presence of a hyaluronate‐binding region on proteoglycans from osteoarthritic cartilage
Authors: Brandt Kenneth D. , Palmoski Marshall J. , Perricone Elaine 
Published: February 2007

AbstractProteoglycan aggregates isolated from normal bovine knee cartilage were larger than those from osteoarthritic cartilage of the same joints and appeared relatively more resistant to digestion with leech hyaluronidase. Incubation of proteoglycan subunits from the arthritic cartilage with hyaluronic acid resulted in marked aggregation, comparable in magnitude to that shown by subunits from normal cartilage. The results indicate that the hyaluronate‐binding region of these proteoglycans was functionally intact and suggest that diminished aggregation of proteoglycans in osteoarthritic cartilage may be due to an abnormality in some other constituent of the aggregates.
Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferon
Authors: Yaron M. , Yaron I. , Smetana O. , Eylan E. , Herzberg M. 
Published: February 2007

AbstractPoly I:C (polyinosinic‐polycytidylic acid) stimulated hyaluronic acid production by rheumatoid and non‐rheumatoid human synovial fibroblasts. Stimulation was dose dependent and was inhibited by acetylsalicylic acid and indomethacin. Poly I and Poly C, when separately added, had no stimulatory effect on hyaluronic acid production, and Poly A:U had only a slight effect on this parameter. Cells grown with Poly I:C were virus resistant and interferon was detected in their medium. Human interferon had also a dose‐dependent stimulatroy effect on hyaluronic acid production by synovial cells. A possible interferon‐mediated relationship between virus infection and pathologic accumulation of joint fluid is suggested.
Chrysotherapy. A prospective study
Authors: Rothermich Norman O. , Philips Vol K. , Bergen Waldemar , Thomas Marvin H. 
Published: February 2007

AbstractA 4‐year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The standard weekly dosage of 50 mg was compared to that based on 1 mg/kg body weight; no significant differences were found. The rapidly absorbed aqueous thiomalate was compared to the slowly absorbed oil repository thioglucose; the latter produced significantly less side effects and an appreciably higher percentage of improvement. Almost half (43%) of nonresponders on standard regimen had a satisfactory clinical response at higher dosage levels without increase in toxicity. Some of these findings vary so much with traditional beliefs and practices that the authors urge caution in their interpretation. But generally speaking these problems are technical and do not detract from the conviction that chrysotherapy is valuable and comparatively safe in the management of rheumatoid arthritis and that it deserves more widespread application in clinical practice.
Serum antibody levels against t mycoplasmas in two north american indian populations predisposed to spondylitis
Authors: Ford Denys K. , Henderson Elizabeth 
Published: February 2007

AbstractSerum antibody levels against T mycoplasmas (Ureaplasma urealyticum) were determined by the metabolic inhibition method in several populations. A higher prevalence of antibody was found in Haida Indians and Bella Coola Indians than in blood donors, patients with rheumatoid arthritis, and patients attending a VD clinic. Antibody levels did not correlate with the presence of spondylitis or the histocompatibility antigen HLA‐B27, although both these Indian populations have a high prevalence of spondylitis and HLA‐B27.
Hypothyroidism presenting as a polymyositis‐like syndrome. Report of two cases
Authors: Hochberg Marc C. , Koppes Gerald M. , Edwards Corwin Q. , Barnes H. Verdain , Arnett Frank C. 
Published: February 2007

AbstractTwo patients with proximal muscle weakness and marked elevations of serum muscle enzymes were initially believed to have polymyositis; however electromyography and muscle biopsies were normal. Both patients were subsequently found to have hypothyroidism. Each regained her muscle strength, and serum enzymes normalized with thyroid hormone replacement. Because muscle weakness and an elevated creatine phosphokinase occur in most patients with hypothyroidism, thyroid dysfunction must be considered in the differential diagnosis of polymyositis.
Progressive systemic sclerosis in a family
Authors: Gray Robert G. , Altman Roy D. , Gray Robert G. , Altman Roy D. 
Published: February 2007

AbstractProgressive systemic sclerosis (PSS) developed in a 6‐year‐old boy and in his 38‐year‐old mother 9 years later. Both parent and child had Raynaud's phenomenon, integumental sclerosis, and pulmonary involvement, but they differed in other aspects of their disease. Previous descriptions of the familial occurrence of PSS are reviewed and compared to the present case reports. Environmental and genetic factors of possible etiologic significance are discussed.
Reiter's syndrome followingshigella flexneri 2a
Authors: Good Armin E. , Schultz Jane S. 
Published: February 2007

AbstractShigella flexneri 2a was isolated from a patient with Reiter's syndrome (RS) following a family outbreak of traveler's diarrhea. Among 3 members at risk, only the patient was positive for HLA‐B27. Data from 3 similar families support the hypothesis that susceptibility to RS is genetically transmitted. It is urged that every effort be made to culture and subtype Shigella and other enteric pathogens in RS following diarrhea. Concurrently, the patient had hepatitis, interpreted as a parallel enteric infection.
Skin basement membrane immunofluorescence in rheumatoid arthritis
Authors: Deboer Daniel C. , Moskowitz Roland W. , Michel Beno 
Published: February 2007

AbstractThirty‐nine patients with rheumatoid arthritis were studied for the presence of skin basement membrane immunofluorescence. Punch biopsies from normal sun‐exposed skin of the forearm were negative for basement membrane immunofluorescence in all cases, except one which was read as questionable. No correlation with serum antinuclear antibody or lupus erythematosus cells was observed. Skin immunofluorescence studies are helpful in differential diagnosis when patients with a clinical picture of rheumatoid arthritis present with serum antinuclear antibodies and lupus erythematosus cells. Positive basement membrane immunofluorescence is strong evidence of systemic lupus erythematosus.
Enhancement of in vitro immunoglobulin synthesis of rheumatoid lymphocytes by aggregated human gamma globulin
Authors: Yamasaki Kuniomi , Ziff Morris 
Published: February 2007

AbstractIn vitro immunoglobulin synthesis by lymphocytes of patients with rheumatoid arthritis (RA) was enhanced by the addition of heat‐aggregated human IgG. Stimulation occurred in the presence of fresh seropositive autologous plasma and was abolished by heat inactivation. By contrast, no significant stimulation was induced in lymphocytes from patients with miscellaneous arthritides and normal subjects cultured in the presence of either fresh autologous plasma or fresh normal AB serum. Although stimulation of RA lymphocytes did not occur in the presence of fresh AB serum, it did when purified IgM rheumatoid factor was added to this serum. These results suggest that immune complexes formed between aggregated IgG and rheumatoid factor in the presence of complement stimulate immunoglobulin synthesis in the peripheral blood lymphocytes of patients with RA.
The university rheumatic disease clinic
Authors: Henke Curtis J. , Yelin Edward H. , Ingbar Mary Lee , Epstein Wallace V. 
Published: February 2007

AbstractA medical school based rheumatic disease clinic provides patient services and educational activities and conducts clinical research. The patient population and routes of access to one such clinic are described, and the effect of direct and indirect costs influencing patient compliance are analyzed. It was found that the program cost of such a facility greatly exceeds the administrative cost. Alternatives to such high‐cost facilities are considered.
Antibody levels to enteric bacteria in juvenile rheumatoid arthritis
Authors: Gutowska‐Grzegorczyk Grazyna , Baum John 
Published: February 2007

AbstractIn order to determine the immunologic status and possible susceptibility to bacterial infection in children with juvenile rheumatoid arthritis (JRA), titers of hemagglutinating antibodies to E coli 055, E coli 086, common antigen, and Shigella polyvalent antigen were measured. Immunoglobulin G was the predominant antibody. IgA antibodies were found in higher titers in children with JRA. No significant differences were found between children with JRA and matched controls. These data show that children with JRA do not have any deficit in antibody production to specific bacterial antigens, and any increased appearance of infection in these children is more probably due to deficiencies in cellular factors.
Chalky joint effusion
Authors: Brandt Kenneth D. , Krey Phoebe R. 
Published: February 2007

AbstractA patient with long‐standing progressive systemic sclerosis developed calcification of the suprapatellar pouch. Chalky white synovial fluid from the knee joint contained many crystals that were characterized as apatite by X‐ray diffraction. In this case massive amounts of crystals were presumably shed into the fluid from the heavily calcified synovium.
Rheumatology manpower in california
Authors: Yelin Edward H. , Henke Curtis J. , Epstein Wallace V. 
Published: February 2007

AbstractCalifornian specialists in the treatment of rheumatic diseases were surveyed to determine the spatial distribution of rheumatologic services in the state, the amount of patient care time available for the rheumatic diseases in each county, the physicians' capacity to treat all rheumatic disease patients who seek their care, and their perception of the need for more specialists in their area. The data resulting from the survey are analyzed by four methods to assess the sufficiency of medical manpower resources.
Quantitation of precipitating antibodies to certain soluble nuclear antigens in sle
Authors: Maddison Peter J. , Reichlin Morris 
Published: February 2007

AbstractElectrophoresis in polyacrylamide gels in the presence of sodium dodecyl sulfate was used to separate and quantitate the components of a washed immune precipitate. Serum was from patients with systemic lupus erythematosus known to have antibodies to soluble nuclear ribonucleoprotein (RNP) or to a soluble nuclear non‐nucleic acid protein (Sm). Amounts of antibody that was predominantly IgG ranged from 0.2 to 8 mg/ml of patients' serum, and in some cases accounted for over 20% of the total serum IgG. Results demonstrate that some patients respond to the disease by producing large amounts of a specific antibody, and that these antibodies can contribute significantly to hypergammaglobulinemia.
Immune complexes and complement catabolism in ankylosing spondylitis
Authors: Gabay R. , Zubler R. H. , Nydegger U. E. , Lambert P. H. 
Published: February 2007

AbstractIn serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly ( > 2 SD ), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.
Association of renal papillary necrosis and ankylosing spondylitis
Authors: Lourie Seth H. , Denman Susan J. , Schroeder Edward T. 
Published: February 2007

AbstractThree patients with ankylosing spondylitis developed renal papillary necrosis. All had received prosta‐glandin synthetase inhibitors including phenylbutazone, indomethacin, or ibuprofen. One patient had sickle trait. These drugs are not commonly associated with papillary necrosis in man, but may adversely effect renal medullary blood flow. An underlying renal vascular abnormality related to ankylosing spondylitis is also considered. Patients with ankylosing spondylitis who are taking prostaglandin synthetase inhibitors should be routinely screened for hematuria.
Phytomitogen‐induced, lymphokine‐mediated cartilage proteoglycan degradation
Authors: Herman Jerome H. , Musgrave Diane S. , Dennis Marie V. 
Published: February 2007

AbstractThe significance of T‐cell activation in the immunopathogenesis of articular disease has been studied in an in vitro model to assess the capacity of phytomitogen‐induced lymphokines to degrade cartilage matrix proteoglycans. Supernatants derived from T‐cell activation of normal human peripheral blood lymphocytes were shown to contain a monocyte‐dependent, serum‐inhibitable, dialyzable factor or factors capable of inducing significant proteoglycan degradation, as assessed by release of macroprecipitable 35S‐labeled proteoglycan from heterologous cartilage substrates.
Papular mucinosis with myopathy, arthritis, and eosinophilia
Authors: Mcadam Lawrence P. , Pearson Carl M. , Pitts William H. , Sadoff Leonard , Verity M. Anthony 
Published: February 2007

AbstractA patient with biopsy‐proven papular mucinosis, plus the characteristic IgG lambda light chain para‐proteinemia, also developed a severe proximal myopathy, seronegative inflammatory polyarthritis, and marked eosinophilia. Muscle enzymes were elevated, EMG was compatible with polymyositis, and muscle biopsy revealed an atypical necrotizing vacuolar myopathy. Synovial biopsy revealed an inflammatory synovitis with Class II synovial fluid. No mucin deposition was detectable in muscle or synovium. During 7 years of observation, corticosteroids and various immunosuppressive agents were successively administered with little benefit. Recently, weekly intravenous methotrexate and low‐dose oral corticosteroids have resulted in clinical and laboratory improvement. It is suggested that the pathology in papular mucinosis may include serious rheumatic manifestations in addition to the cutaneous involvement.