bluuebunny/crossref_metadata_2025_split huggingface dataset:
The causal relationship between genetically predicted blood metabolites and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study
Authors: Pan Tingyu , Bai Le , Zhu Dongwei , Wei Yun , Zhao Qi , Feng Fanchao , Wang Zhichao , Xu Yong , Zhou Xianmei 
Published: April 2024

Background
Numerous metabolomic studies have confirmed the pivotal role of metabolic abnormalities in the development of idiopathic pulmonary fibrosis (IPF). Nevertheless, there is a lack of evidence on the causal relationship between circulating metabolites and the risk of IPF.

Methods
The potential causality between 486 blood metabolites and IPF was determined through a bidirectional two-sample Mendelian randomization (TSMR) analysis. A genome-wide association study (GWAS) involving 7,824 participants was performed to analyze metabolite data, and a GWAS meta-analysis involving 6,257 IPF cases and 947,616 control European subjects was conducted to analyze IPF data. The TSMR analysis was performed primarily with the inverse variance weighted model, supplemented by weighted mode, MR-Egger regression, and weighted median estimators. A battery of sensitivity analyses was performed, including horizontal pleiotropy assessment, heterogeneity test, Steiger test, and leave-one-out analysis. Furthermore, replication analysis and meta-analysis were conducted with another GWAS dataset of IPF containing 4,125 IPF cases and 20,464 control subjects. Mediation analyses were used to identify the mediating role of confounders in the effect of metabolites on IPF.

Results
There were four metabolites associated with the elevated risk of IPF, namely glucose (odds ratio [OR] = 2.49, 95% confidence interval [95%CI] = 1.13–5.49, P = 0.024), urea (OR = 6.24, 95% CI = 1.77–22.02, P = 0.004), guanosine (OR = 1.57, 95%CI = 1.07–2.30, P = 0.021), and ADpSGEGDFXAEGGGVR (OR = 1.70, 95%CI = 1.00–2.88, P = 0.0496). Of note, the effect of guanosine on IPF was found to be mediated by gastroesophageal reflux disease. Reverse Mendelian randomization analysis displayed that IPF might slightly elevate guanosine levels in the blood.

Conclusion
Conclusively, hyperglycemia may confer a promoting effect on IPF, highlighting that attention should be paid to the relationship between diabetes and IPF, not solely to the diagnosis of diabetes. Additionally, urea, guanosine, and ADpSGEGDFXAEGGGVR also facilitate the development of IPF. This study may provide a reference for analyzing the potential mechanism of IPF and carry implications for the prevention and treatment of IPF.
Prevalence and factors associated with psychological distress among key populations in Nigeria
Authors: Ochonye Bartholomew , Emmanuel Godwin , Abang Roger , Sanni Olaniyi Felix , Umoh Paul , Kalaiwo Abiye , Mwoltu Nanribet , Amechi Paul , Motilewa Olugbemi 
Published: April 2024

Background
Stigmatization and discrimination within healthcare settings deter key populations (KPs) from seeking mental health and psychosocial support (MHPS). Consequently, understanding the prevalence, associated factors, and impact of the MHPSS intervention on psychological distress among Nigeria’s KPs is crucial.

Method
This is a cross-sectional study focused on KPs, including Female Sex Workers (FSW), Men who have Sex with Men (MSM), and People Who Inject Drugs (PWID) enrolled in Heartland Alliance LTD/GTE across 17 One-Stop Shops (OSS) in six states of Nigeria. Data were extracted from the databases of the OSS. PD was assessed using the Mental Health Screening Form III (MHSF-III). Descriptive statistics and univariable and multivariable binary logistic regression models were done using IBM-SPSS version 28.

Results
The prevalence of PD among the KPs was 9.7%. Higher rates were observed among FSWs (12.0%). Of the 22310 KPs, the prevalence of PD was 9.7%. The major dependants of PD include being a PWID with PD prevalence of 8.5% and AOR of 1.95 (95% CI: 0.60–0.98, p = 0.015), alcohol intake with PD prevalence of 97.7% and AOR of 21.83 (95% CI: 15.13–56.83, p<0.001), and having experienced gender-based violence with PD prevalence of 99.0% and AOR of 25.70(95% CI: 17.10–38.73, p<0.001). All Participants (100%) were given brief intervention, and 1595 of 2159 (73.8%) were referred for further psychological intervention. The services with the highest proportion were psychoeducation (21.20%), followed by coping skills training (17.70%) and motivational enhancement (12.90%).

Conclusion
The study highlights the critical need for targeted mental health interventions among KPs in Nigeria, primarily focusing on those with a history of substance abuse and gender-based violence. Despite universal brief interventions, the proportion enrolled in further Psychosocial support indicates a need to improve mental health service utilization among the KPs in Nigeria.
Marginal fit of 3-unit implant-supported fixed partial dentures: Influence of pattern fabrication method and repeated porcelain firings
Authors: Giti Rashin , Farrahi Pardis 
Published: April 2024

BackgroundMarginal fit significantly impacts the long-term success of dental restorations. Different pattern fabrication methods, including hand-waxing, milling, or 3D printing, may affect restorations accuracy. The effect of porcelain firing cycles on the marginal fit of metal-ceramic restorations remains controversial, with conflicting findings across studies.PurposeThe aim was to evaluate the potential effects of multiple porcelain firings (3, 5, 7 cycles) as well as pattern fabrication method (conventional hand-waxing, milling, and 3D printing) on the marginal adaptation of 3-unit implant-supported metal-ceramic fixed partial dentures. It was hypothesized that neither the wax pattern fabrication method nor repeated ceramic firings would significantly affect the marginal adaptation of metal-ceramic crowns.MethodsIn this in-vitro study, 30 Cobalt-Chromium alloy frameworks were fabricated based on pattern made through three techniques: conventional hand-waxing, CAD-CAM milling, and CAD-CAM 3D printing (n= 10 per group). Sixteen locations were marked on each abutment to measure the vertical marginal gap at four stages: before porcelain veneering and after 3, 5, and 7 firing cycles. The vertical marginal gap was measured using direct microscopic technique at ×80 magnification. Mean vertical marginal gap values were calculated and two-way ANOVA and Tukey’s post hoc tests were used for inter-group comparisons (α = 0.05).ResultsThe 3D printing group showed significantly lower (P<0.001) mean vertical marginal gaps (60–76 μm) compared to the milling (77–115 μm) and conventional hand-waxing (102–110 μm) groups. The milling group exhibited a significant vertical gap increase after 3 firing cycles (P<0.001); while the conventional (P= 0.429) and 3D printing groups (P= 0.501) showed no significant changes after 7 firing cycles. Notably, the vertical marginal gap in all groups remained below the clinically acceptable threshold of 120 μm.ConclusionCAD-CAM 3D printing provided superior marginal fit compared to CAD-CAM milling and conventional hand-wax pattern fabrication methods. The impact of porcelain firing on the mean marginal gap was significant only in the milling group. All three fabrication techniques yielded clinically acceptable vertical marginal adaptation after repeated firings. Additive manufacturing holds promise to produce precise implant-supported prostheses.
Dietary total antioxidant capacity of Moroccan Type 2 Diabetes Mellitus patients
Authors: El Frakchi Najia , El Kinany Khaoula , El Baldi Marwa , Saoud Younes , El Rhazi Karima 
Published: April 2024

AimsA new approach to a healthy diet is the assessment of dietary Total Antioxidant Capacity (TAC). The aim of this study was to assess the dietary TAC among Moroccan Type 2 Diabetes Mellitus (T2DM) patients and identify the main food sources contributing to the total antioxidant capacity intake.MethodsA total of 254 patients with T2DM was included in the study. The usual dietary intakes were assessed by means of a validated food frequency questionnaire. The dietary TAC was estimated using published databases of the antioxidant content of foods measured by the FRAP (ferric ion reducing antioxidant potential) method.ResultsThe mean (SD) dietary TAC of the studied type 2 diabetes patients was 10.86 (3.42) mmol/day. Correlation analyses showed a positive association between dietary TAC and the consumption of healthy food groups, such as fruits and vegetables. Tea and coffee beverages (38.6%), vegetables (21.9%), cereals and pulses (18.8%), fruits and fruit juices (12.4%) were major food sources of dietary antioxidant intake. The relatively short list of twenty food items that contributed most to dietary TAC presented an important explanation of roughly 94%. These included tea, coffee, broad beans, artichoke, pepper, beetroot, sweet potatoes, pomegranate, mandarin, figs, strawberry, orange juice, olives, cashew nuts, almonds, sunflower seeds, dchicha and white beans.ConclusionsThis study supplies baseline dietary TAC data for Moroccan T2DM patients that may help to elucidate which aspects of the eating habits and behaviours require improvement and provide the opportunity to develop dietary guidelines as part of the nutritional diabetes management.
Translation and cross-cultural adaptation of Persian version of Evidence Based Medicine Questionnaire (EBMQ) in postgraduate medical students in Iran
Authors: Danaei Ziba , Madadizadeh Farzan , Sheikhshoaei Fatemeh , Dehdarirad Hossein 
Published: April 2024

Background
Evidence Based Medicine Questionnaire (EBMQ) was developed to assess the knowledge, practice and barriers towards the implementation of Evidence-Based Medicine (EBM). This study aimed to translate, cross-culturally adapt and psychometrically validate the Persian version of EBMQ.

Methods
This was an analytical cross sectional study. The EBMQ underwent translation and cross-cultural adaptation following best practices. Face validity was assessed by a panel of five experts. The content validity index (CVI) and content validity ratio (CVR) were evaluated by 15 experts who were familiar with EBM. The tool’s internal consistency and test-retest reliability over a 2-week period were evaluated using Cronbach’s α and intra-class correlation (ICC), respectively. To assess construct validity, the questionnaire was completed by 400 medical students. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used for construct validity assessment. All analyses were carried out using IBM SPSS v.24 and AMOS v.24. A significance level of 5% was considered.

Results
The CVR for 40 items was higher than 0.62, and their CVI score was 1.0, indicating good content validity. The scale demonstrated acceptable internal consistency and test-retest reliability (n = 30) with an ICC of 0.909 (95% CI: 0.866 to 0.941), and an overall alpha coefficient of 0.957. The structural validity was established through exploratory factor analysis (Bartlett’s test p<0.001; the Kaiser-Meyer-Olkin index = 0.862), and it was further confirmed by confirmatory factor analysis. A three-factor solution with 40 items, explaining 51.610% of the variance, exhibited the best fit indices Chi-square statistics/df = 4.23; RMSEA = 0.08; CFI = 0.95; NFI = 0.93; TLI = 0.92).

Conclusion
The Persian version of the EBMQ was a reliable and valid tool that could be utilized to assess the knowledge, practice and barriers of EBM for physicians in Persian language countries.
Survey from 61,748 schools in four States of India on sale of tobacco products near schools
Authors: Sarin Ashima , Seth Sanjay , Sethi Barkha , Singhavi Hitesh R. 
Published: April 2024

Background
Children form the most vulnerable strata of the society and the tobacco industry is known to target them. Article 16 of the Framework Convention of Tobacco Control (FCTC) calls for prohibition of tobacco sales to and by minors. Although interventions to stop such sales are based on sound science, it is widely acknowledged that many countries find implementation, full of challenges. In India, sales near educational institutions are banned by law, Section 6b of the Cigarettes & Other Tobacco Products Act (COTPA). We conducted a survey of violations in four states [Andhra Pradesh (AP), Karnataka (KA), Meghalaya (ML), Uttar Pradesh (UP)] of India to report the number of violations and to assess if there was an association between the schools with violations and variables such as gender, size, category, location of schools.

Methods
Schools in these States were asked to report the number of shops selling tobacco within 100 yards on an App circulated to all schools (289,392 in number). Chi-square tests, univariate and multivariate logistic regression performed to find association between schools with violations by Category of School, Size of School, Gender of students and location (Urban/Rural).

Findings
Responses were received from 61,748 (21.3%) schools of which 16,193 (26.2%) reported violations. It was observed that the percentages of the schools with violations were similar to the prevalence of tobacco usage in the state. Four states AP, KA, ML, UP reported violations 22.2%, 17.5%, 42.9% and 31.4% respectively. On chi-square tests, there was a significant association for the states of KA and ML with regards to variables like size, category, location of schools (p-value <0.001). For AP, all variables were significantly different (p-value <0.001) while for UP variables like size and gender were significant. On logistic regression, there was significant association between the variables like size (>100), category (Upper Primary) and location (urban) for tobacco shops violations in both KA and ML except for the school category that was secondary in ML. While for AP and UP, only size (>100), location (urban) of schools have a significant association with the violations of tobacco shops. Logistic regression of pooled data of four states school size (>100) and school category (primary) and location (urban) had significantly higher association of violation of tobacco shops.

Interpretation
This is the first large survey with responses from almost all parts of the four states in India. This study shows significant association with the size, category and location of schools. We anticipate that the lists of schools which have such violations can be used by enforcement agencies to take focused action. Such models will help develop effective tobacco control policies in developing countries with large populations where implementation remains a big challenge.
Can serum interleukin 34 levels be used as an indicator for the prediction and prognosis of COVID-19?
Authors: Karahan Doğu , Bolayir Hasan Ata , Bolayir Aslı , Demir Bilgehan , Otlu Önder , Erdem Mehmet 
Published: April 2024

Objective
Interleukin 34 (IL-34) is a molecule whose expression is increased in conditions such as autoimmune disorders, inflammation, and infections. Our study aims to determine the role of IL-34 in the diagnosis, follow-up, and prognosis of Coronavirus Disease-19 (COVID-19).

Method
A total of 80 cases were included in the study as 40 COVID-19 positive patient groups and 40 COVID-19 negative control groups. The COVID-19-positive group consisted of 20 intensive-care unit (ICU) patients and 20 outpatients. Serum IL-34, c-reactive protein (CRP), ferritin, D-dimer, troponin I, hemogram, and biochemical parameters of the cases were studied and compared between groups.

Results
IL-34 levels were significantly higher in the COVID-19-positive group than in the negative group. IL-34 levels increased in correlation with CRP in predicting the diagnosis of COVID-19. IL-34 levels higher than 31.75 pg/m predicted a diagnosis of COVID-19. IL-34 levels did not differ between the outpatient and ICU groups in COVID-19-positive patients. IL-34 levels were also not different between those with and without lung involvement.

Conclusion
While IL-34 levels increased in COVID-19-positive patients and were successful in predicting the diagnosis of COVID-19, it was not found to be significant in determining lung involvement, risk of intensive care hospitalization, and prognosis. The role of IL-34 in COVID-19 deserves further evaluation.
The effectiveness of savouring interventions on well-being in adult clinical populations: A protocol for a systematic review
Authors: Cullen Katie , Murphy Mike , Di Blasi Zelda , Bryant Fred B. 
Published: April 2024

Purpose
Savouring interventions aim to amplify the intensity and duration of positive feelings and positive affect. Research has shown that the potential benefits of savouring include the promotion of psychological well-being and diminution of negative affective states. Savouring strategies may be particularly useful amongst clinical populations in changing biobehavioural processes which can strengthen an individual’s propensity to exert control over how to develop, intensify and promote psychological well-being, while simultaneously mitigating negative affective states. This paper outlines a protocol for a systematic review that will be used to identify, critically appraise and synthesise findings of studies examining the effectiveness of savouring interventions in adult clinical populations. Savouring interventions will be defined broadly, operationalised as any savouring strategy focusing on past, present or future events or experiences whereby participants are instructed to attend to and amplify positive affect relating to same. The goal of our review is to include the extent of the literature on this topic and contribute to the overall evidence to support savouring interventions.

Methods
This protocol is carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Protocols Guidelines. The protocol has been registered with PROSPERO (CRD42023404857). The databases PsycINFO, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Scopus will be searched alongside a search of grey literature. An examination of the first 200 papers on Google Scholar will also be done to identify relevant papers. Studies describing randomised controlled trials evaluating the effects of savouring interventions as described within this article on adult clinical populations will be included in the review. Outcomes will include well-being, quality of life, depression, anxiety or stress. Study selection and data extraction will be completed by three independent reviewers to reduce risk of bias. Interrater percentage agreement and interrater reliability will be reported on same. The quality of studies will be assessed using criteria based on the Cochrane Collaboration’s tool for assessing risk of bias and the Jadad scale. A narrative synthesis with tables of study characteristics will be provided. Separate considerations of the three time perspectives of savouring interventions (past-focused, present-focused, and future-focused) will also be described.

Conclusions
This systematic review will provide important clinical insights into the potential efficacy of savouring interventions when working with adult clinical samples.
Assessing the COVID-19 pandemic’s impact on pediatric baseball and basketball-related craniofacial and neck injuries treated in United States emergency departments, 2003–2022
Authors: Wiener R. Constance , Lundstrom Eric W. 
Published: April 2024

Background
A large proportion of United States (U.S.) youth play basketball, baseball, softball, or T-ball. Each of the activities poses a documented risk of craniofacial and neck injuries. However, few studies have assessed the national prevalence of pediatric craniofacial and neck injuries in this population, particularly following the COVID-19 pandemic.

Methods
The National Electronic Injury Surveillance System (NEISS) dataset was used to identify pediatric craniofacial and neck injuries associated with basketball, baseball, softball, or T-ball from 2003–2022 in a cross-sectional study. The annual number of injuries before and after the onset of the COVID-19 pandemic with 95% confidence intervals were calculated. Interrupted time series analysis (ITSA) was used to estimate the pandemic’s impact on the monthly number of injuries incurred nationally.

Results
Both overall and stratified by sport involvement, the annual number and rate of injuries identified in NEISS decreased significantly after the COVID-19 pandemic. ITSA demonstrated that the monthly number of injuries decreased -4094.4 (95% CI = -5100, -3088.7) immediately after the beginning of the pandemic. The number of injuries began increasing towards pre-pandemic levels at a rate of 110.6 (95% CI = 64, 157.2) injuries per month after the initial plunge.

Conclusion
Prior to the-pandemic, there was a steady decline in craniofacial and neck injuries due to basketball, baseball, softball and T-ball among children, aged <18 years. The shutdown during the initial months of the COVID-19 pandemic resulted in a precipitous drop in such injuries. Current rates are approaching pre-pandemic levels and may exceed them. Continued efforts are needed to keep the pre-pandemic progress.
Obesity and the nervous system
Authors: Antonova K. V. , Tanashyan M. M. , Raskurazhev A. A. , Spryshkov N. E. , Panina A. A. , Lagoda O. V. , Ametov A. S. , Troshina E. A. 
Published: April 2024

The article discusses certain aspects of the relationship between neurological diseases and metabolic disorders that are extremely relevant in connection with the pandemic spread of obesity. The pathogenesis of damage to the nervous system (NS) is considered in detail. The influence of the main metabolic factors on the development of cerebrovascular diseases (CVD), incl. neuroinflammation, changes in hemostasis, etc. is demonstrated. The problem of the development of cognitive dysfunction against the background of obesity due to the formation of atrophic processes in brain structures is highlighted. Modern possibilities of evaluation and modulation of eating behavior due to brain stimulation using functional magnetic resonance imaging (fMRI) and navigational rhythmic transcranial magnetic stimulation (rTMS) are described.The problem of cerebrometabolic health is presented as a continuum of metabolic and cerebral disturbances. The mechanisms of interaction between the two most important systems of the body allow us to consider the changes that occur in them as an integral neuroendocrine alteration.
Analisis Lingkungan Pengendapan dan Karakteristik Material Organik Daerah Air Putih, Kota Samarinda, Indonesia
Authors: Jamaluddin Jamaluddin , Rahmawati Diana , . Maria 
Published: April 2024

Penelitian tentang lingkungan pengendapan dan karakteristik material organik pada serpih dan batubara yang terdapat pada daerah Air Putih, Kota Samarinda sangat penting untuk dikaji sebagai indikator kemampuan suatu batuan sedimen untuk menghasilkan hidrokarbon. Daerah penelitian termasuk kedalam Formasi Balikpapan yang kaya bahan organik. Stratigrafi batuan sedimen yang dijumpai daerah penelitian merupakan asosiasi fasies prodelta shales yang prograding menjadi delta front mouth bar. Nilai TOC pada percontoh batuan yang terdapat pada daerah penelitian berkisar 0,62 % - 64,39 % yang terdiri atas batulanau, serpih, dan batubara. Material organik pada Daerah Air Putih sebagian besar terendapkan di lingkungan laut dan beberapa sampel terendapakan pada lingkungan air tawar dalam kondisi reduksi. Komposisi maseral batubara pada sampel SMC daerah Air Putih terdiri atas huminit 73%, liptinit 26% dan inertinit 1% sedangkan serpih terdiri atas vitrinit 55%, liptinit 43% dan inertinit 2%. Akumulasi material organik pada daerah Air Putih pada umumnya berasosiasi dengan serpih hitam dan batubara pada lingkungan delta plain umumnya berupa material organik asal darat.