bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct bonding conditions of ferrite garnet layer on ion‐exchanged glass waveguides
Authors: Joudrier Anne‐Laure , Couchaud Maurice , Moriceau Hubert , Broquin Jean‐Emmanuel , Ferrand Bernard , Deschanvres Jean‐Luc 
Published: August 2008

AbstractIn order to realize an integrated optical isolator, a new hybrid optical structure has been proposed. This structure is composed of an active magneto‐optic garnet layer with a strong refractive index, transferred on a passive ion‐exchanged glass waveguide. Given the thermal restraints relating to the stability of the glass waveguides, the process used to achieve this hybrid structure is composed of two main steps: firstly, good quality garnet films were grown by liquid phase epitaxy, then these active films were bonded successfully on glass wafer. According to modelling, the thickness of the garnet layer does not exceed 300 nm for maintaining a good confinement. Good wafer bondings on ion‐exchanged glass waveguides are obtained. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Preparation of Heusler thin films: The quaternary alloy Co2Fe0.5Mn0.5Si
Authors: Ebke D. , Thomas A. , Hütten A. , Balke B. , Felser C. , Schmalhorst J. , Reiss G. 
Published: August 2008

AbstractIn this work the basic strategies for the preparation of Co2Mn0.5Fe0.5Si as an example for Heusler alloy thin films will be described. Texture and magnetic properties of these films will be discussed, especially with regard to different buffer layers and annealing temperatures. Finally, we will show the integration of Heusler thin films into magnetic tunnel junctions (MTJs) and calculate the effective spin polarization. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influences of partial melting and overheating on amorphization of Ge2Sb2Te5 during the reset process
Authors: Youm Min Soo , Kim Yong Tae , Sung Man Young 
Published: August 2008

AbstractIt is very important to observe the change in the atomic structure of melt‐quenched amorphous Ge2Sb2Te5 (GST) to discover the failure mechanism of phase‐change random access memory (PRAM) devices during the reset process. We fabricated the phase‐change devices and measured the initial resistance changes with various reset pulse amplitudes. For the observation of the atomic structure changes of GST thin films, we designed the specimens for transmission electron microscopy (TEM) and annealed them below and above the melting temperature of GST (Tm = 650 °C) before quenching. The annealed‐and‐quenched GST at 630 °C has a hexagonal structure with a grain size of about 10 nm after the partial melting. The annealed‐and‐quenched GST at 750 °C also has a hexagonal structure because of the latent heat. The observed atomic structures of GST are in accordance with the resistance changes inferred from the fabricated edge‐contact type of PRAM cell. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effect of vacancies on copper precipitation in n‐type Czochralski silicon
Authors: Wang Weiyan , Yang Deren , Ma Xiangyang , Que Duanlin 
Published: August 2008

AbstractThe effect of vacancies induced by the prior rapid thermal processing (RTP) at 900–1200 °C in Ar on copper (Cu) precipitation in n‐type silicon has been investigated by means of optical microscopy and transmission electron microscopy. It was revealed that in the sample without the prior RTP, the Cu precipitates appeared as spheres with sizes of about 100 nm and, moreover, induced stress in the matrix. In this case, they were preferentially delineated as etch pits. Whereas, for the samples with the prior RTP at 1000 °C and above, the Cu‐precipitate colonies, in which a number of sphere‐like Cu precipitates with sizes of 10–20 nm assembled on and around the climbing dislocations, formed with different depth profiles dependent on the prior RTP temperature. The formation of Cu‐precipitate colonies and their depth profile were tentatively explained in terms of the induced vacancies and their related defects. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis and detailed kinetic analysis using computerized glow‐curve deconvolution technique of nanocrystalline Sr3Al2O6:Pr3+ – A new phosphor for UV applications
Authors: Sharma Suchinder K. , Pitale Shreyas S. , Malik M. Manzar , Dubey R. N. , Qureshi M. S. 
Published: August 2008

AbstractPr3+‐doped nanocrystalline Sr3Al2O6 phosphor, synthesized through solution combustion route and calcined at 1100 °C is reported in this paper. The crystallinity checks followed by phosphorescence decay studies were performed to define the decaying rates of the present phosphor system. Thermoluminescence studies after UV‐irradiation were performed at room temperature and the glow peak obtained possesses three well‐defined temperature maxima at 383.75 K, 428 K and 509 K. Tm–Tstop and the repeated initial rise method (RIR) is applied to estimate approximate peak positions and the energy values for computerized glow‐curve deconvolution. The nonshifting Tm property is applied to define the order of kinetics. The calculated activation energy after deconvolution lies between 0.72 eV and 1.28 eV distributed into eight different levels. The frequency factor is of the order of 109 s–1 to 1011 s–1. The figure of merit for deconvolution is 1.6%. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Focused‐ion‐beam fabrication of ZnO nanorod‐based UV photodetector using the in‐situ lift‐out technique
Authors: Lupan Oleg , Chow Lee , Chai Guangyu , Chernyak Leonid , Lopatiuk‐Tirpak Olena , Heinrich Helge 
Published: August 2008

AbstractZnO nanorods and nanowires are promising candidates as new types of high‐sensitivity ultraviolet (UV) photodetectors due to their wide bandgap and large aspect ratio. In this study, single‐crystalline ZnO nanorods were grown on glass substrates by a hydrothermal method. Specific structural, morphological, electrical, and optical measurements were carried out. A single ZnO nanorod‐based photodetector was fabricated using the in‐situ lift‐out technique in a focused ion beam (FIB/SEM) instrument and characterized. With a source wavelength of 370 nm and an applied bias of 1 V, the responsivity of the ZnO nanorod is 30 mA/W. The single ZnO nanorod photodetector exhibits an ultraviolet (UV) photoresponse promising for potential applications as cost‐effective UV detectors. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A better understanding of the growth mechanism of Zn(S,O,OH) chemical bath deposited buffer layers for high efficiency Cu(In,Ga)(S,Se)2 solar cells
Authors: Hubert C. , Naghavi N. , Etcheberry A. , Roussel O. , Hariskos D. , Powalla M. , Kerrec O. , Lincot D. 
Published: August 2008

AbstractIn the field of Cu(Ga,In)(S,Se)2 photovoltaic technology, zinc sulphide based buffer layers prepared by Chemical Bath Deposition (CBD) have already demonstrated their potential to replace CdS. This paper aims on a better understanding of deposition mechanism of the Zn(S,O,OH) buffer layers. First, the influence of deposition parameters is studied from solution chemistry considerations by constructing solubility diagrams of ZnS, ZnO, and Zn(OH)2. Experimental studies are then carried out by the in situ quartz crystal microgravimetry (QCM) technique. A global equation for the growth rate is derived from these experiments. The morphology and composition of Zn(S,O,OH) films are then determined using scanning electron microscopy and X‐ray photoelectron spectroscopy techniques. Electro‐deposited‐CIS/Zn(S,O,OH)/ZnO and co‐evaporated‐CIGS/Zn(S,O,OH)/ZnO cells were prepared with efficiencies similar to that of reference CBD CdS buffer layers. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract Formulation
Authors: Pipingas Andrew , Silberstein Richard B. , Vitetta Luis , Rooy Cindy Van , Harris Elizabeth V. , Young Joanna M. , Frampton Christopher M. , Sali Avni , Nastasi Joseph 
Published: August 2008

AbstractDietary interventions may have the potential to counter age‐related cognitive decline. Studies have demonstrated an improvement in age‐related cognitive impairment in animals after supplementation with plant extracts containing flavonoids but there are few human studies. This double‐blind, controlled study examined the effects on cognitive performance of a 5 week supplementation with Enzogenol® Pinus radiata bark extract containing flavonoids, in 42 males aged 50–65 years, with a body mass index >25. Participants were supplemented for 5 weeks either with Enzogenol® plus vitamin C, or with vitamin C only. A battery of computerized cognitive tests was administered, and cardiovascular and haematological parameters were assessed prior to and following supplementation. The speed of response for the spatial working memory and immediate recognition tasks improved after supplementation with Enzogenol® plus vitamin C, whereas vitamin C alone showed no improvements. A trend in a reduction of systolic blood pressure was observed with Enzogenol® plus vitamin C, but not with vitamin C alone. The blood safety parameters were unchanged. The findings suggest a beneficial effect of supplementation with Enzogenol® on cognition in older individuals. Larger studies are needed to ascertain its potential as a preventive treatment for age‐related cognitive decline. Copyright © 2008 John Wiley & Sons, Ltd.
Antiplatelet activities of newly synthesized derivatives of piperlongumine
Authors: Park Byeoung‐Soo , Son Dong‐Ju , Choi Won‐Sik , Takeoka Gary R. , Han Sung Ok , Kim Tae‐Wan , Lee Sung‐Eun 
Published: August 2008

AbstractPiperlongumine, a pyridone alkaloid isolated from Piper longum L., exhibited a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA) and platelet activating factor (PAF), without any inhibitory effect on that induced by thrombin. Piperlongumine was used as a lead compound for the synthesis of new antiplatelet agents. Seven synthetic compounds were newly synthesized from 3,4,5‐trimethoxycinnamic acid (TMCA). They were 1‐piperidin‐1‐yl‐3‐(3,4,5‐trimethoxy‐phenyl)prop‐2‐en‐1‐one (1′), 1‐morpholin‐4‐yl‐3‐(3,4,5‐trimethoxyphenyl)prop‐2‐en‐1‐one (2′), 1‐(3,5‐dimethylpiperidin‐1‐yl)‐3‐(3,4,5‐trimethoxyphenyl)prop‐2‐en‐1‐one (3′), 1‐(2‐methylpiperidin‐1‐yl)‐3‐(3,4,5‐tri‐methoxyphenyl)prop‐2‐en‐1‐one (4′), 1‐(3‐hydroxypiperidin‐1‐yl)‐3‐(3,4,5‐trimethoxyphenyl)‐ prop‐2‐en‐1‐one (5′), 1‐[3‐(3,4,5‐tri‐methoxyphenyl) acryloyl]‐piperidin‐2‐one (6′) and ethyl 1‐[3‐(3,4,5‐trimethoxyphenyl)‐acryloyl]piperidine‐4‐carboxylate (7′). Among those seven synthetic derivatives, 1‐(3,5‐dimethylpiperidin‐1‐yl)‐3‐(3,4,5‐trimethoxyphenyl)prop‐2‐en‐1‐one (3′) had the most inhibitory effect on platelet aggregation induced by collagen, AA and PAF. Copyright © 2008 John Wiley & Sons, Ltd.
Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women
Authors: Yan Fang‐Fang , Liu Yan , Liu Yun‐Fang , Zhao Yu‐Xia 
Published: August 2008

AbstractHormone replacement therapy (HRT) can ameliorate lipid metabolism after menopause, but it is not suitable for long‐term use because of serious side effects. Herba Epimedii is a widely used herbal medicine in many Asian countries, it potentially treats menopausal syndrome and its complications with few side effects and good curative effects. The study aimed to evaluate the effects of Herba Epimedii water extract on blood lipid and sex hormone levels. Ninety subjects were randomly divided into two groups: a trial group which received Herba Epimedii water extract and a control group which was administered an equal amount of water placebo. At the baseline and after 6 months of medication, serum estradiol (E2), progesterone (P), testosterone (T), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL‐C) and low density lipoprotein cholesterol (LDL‐C) concentrations were measured. The results indicated that Herba Epimedii water extract decreased the TC and TG levels (p < 0.01). Furthermore, Herba Epimedii water extract significantly increased the serum level of E2 (p < 0.01) compared with the pre‐treatment level. In conclusion, Herba Epimedii water extract produces its beneficial actions in postmenopausal women. Copyright © 2008 John Wiley & Sons, Ltd.
Effect of honey on intestinal morphology, intraabdominal adhesions and anastomotic healing
Authors: Gollu Avni , Kismet Kemal , Kilicoglu Bulent , Erel Serap , Gonultas Mehmet Alpaslan , Sunay Asli Elif , Akkus Mehmet Ali 
Published: August 2008

AbstractIn the present study, attempts have been made to determine the effects of honey on intestinal morphology, postoperative adhesions, and the healing of colonic anastomoses in the rats after colonic resection and anastomosis. Thirty‐six rats were randomly divided into three groups each including 12 animals. Colonic resection and anastomosis were performed on all animals. Rats were fed with standard rat chow in group I, standard rat chow plus 10 g/kg/day honey in group II and artificial honey including the same caloric amount with honey in group III. Adhesion scores, bursting pressures and histopathological examinations were evaluated. Colonic bursting pressures of honey group were significantly better than control and artificial honey groups. Histological analysis of anastomotic site showed that submucosa and muscularis propria were nearly filled with granulation tissue and regular fibrin matrix in honey group. There was statistically significant difference between the adhesion scores of honey vs artificial honey and control groups. The scores of histological changes of ileum in honey group were significantly different from other groups. These results indicate a protective role of honey against intraabdominal adhesions and anastomotic dehiscence. Copyright © 2008 John Wiley & Sons, Ltd.
Triterpenoids and a sterol from the stem‐bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities
Authors: Kwon Joo‐Hee , Chang Min‐Jung , Seo Hyo‐Won , Lee Jeong‐Hun , Min Byung‐Sun , Na MinKyun , Kim Jin Cheol , Woo Mi Hee , Choi Jae Sue , Lee Hyeong Kyu , Bae KiHwan 
Published: August 2008

AbstractFive pentacyclic triterpenoids (1–5) and a sterol (6) were isolated from the stem‐bark of Styrax japonica. The six compounds, 1–6, were determined to be 3β‐acetoxy‐28‐hydroxyolean‐12‐ene (1), 3β‐acetoxyolean‐12‐en‐28‐acid (2), 3β‐acetoxyolean‐12‐en‐28‐aldehyde (3), 3β‐acetoxy‐17β‐hydroxy‐28‐norolean‐12‐ene (4), taraxerol (5) and stigmasterol (6), respectively, by spectroscopic means, including the 2D‐NMR technique. Compound 4 is a newly discovered natural compound. The protein tyrosine phosphatase 1B (PTP1B) inhibitory activities of the isolated compounds (1–6) were determined in vitro. Among the isolated compounds, 3β‐acetoxyolean‐12‐en‐28‐acid (2) and 3β‐acetoxyolean‐12‐en‐28‐aldehyde (3) had the most potent inhibitory PTP1B activity, with IC50 values of 7.8 and 9.3 µm, respectively. Copyright © 2008 John Wiley & Sons, Ltd.
Effects ofPolygala tenuifoliaroot extract on proliferation of neural stem cells in the hippocampal CA1 region
Authors: Park Hyun‐Ju , Lee Kiwon , Heo Hwon , Lee Myoungsun , Kim Jong Woo , Whang Wei Wan , Kwon Yunhee Kim , Kwon Hyockman 
Published: August 2008

AbstractNeurogenesis persists in the adult mammalian brain and can be a target for modulation for therapeutic purposes. This study investigated the effect of aPolygala tenuifoliaroot extract on the proliferation of a stem cell population in the rat hippocampus. The root extract ofP. tenuifolia(2 mg/kg/day, 14 times intraperitoneal injections) increased the incorporation of bromodeoxyuridine (BrdU) into cells in the hippocampal CA1 region. This activity was enriched in the saponin‐containing fraction. The majority of cells labelled with BrdU were immunoreactive to nestin or Tuj1 and the percentages of nestin/BrdU‐ and Tuj1/BrdU‐double positive cells were increased by theP. tenuifoliaroot extract, suggesting that theP. tenuifoliaroot extract promotes the proliferation of neural stem cells. In addition, this extract promoted the neurite outgrowth of rat neuronal precursor cells, HiB5. These activities ofP. tenuifoliaroot extract may contribute to the therapeutic benefits of herbal medicines containingP. tenuifoliaroot for the treatment of patients with insomnia, neurosis and dementia. Copyright © 2008 John Wiley & Sons, Ltd.
Antimalarial activity of natural product extracts from Papua New Guinean and Australian plants against Plasmodium falciparum
Authors: Fernandez Liza S. , Jobling Michael F. , Andrews Katherine T. , Avery Vicky M. 
Published: August 2008

AbstractIn the search for new antimalarial compounds, a subset of a natural product extract library prepared from plant samples collected from Papua New Guinea and Australia was screened for in vitro activity against the chloroquine‐sensitive 3D7 and chloroquine‐resistant Dd2 strains of Plasmodium falciparum. Using the incorporation of (3H)‐hypoxanthine into parasite nucleic acid as a marker of growth, 93 of the 794 extracts screened displayed >40% inhibition against 3D7 infected erythrocytes at 312 µge/mL. Antimalarial activity was confirmed in 48 of these extracts against both 3D7 and Dd2 infected erythrocytes at concentrations between 78 and 390 µge/mL, 14 of which caused >90% growth inhibition of 3D7 at the lowest concentration screened. Extracts were also tested for mammalian cell cytotoxicity to evaluate selectivity of action. Copyright © 2008 John Wiley & Sons, Ltd.
Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study
Authors: Santos Vagner R. , Gomes Rafael T. , Mesquita Ricardo A. de , Moura Mariela D. G. de , França Esdras C. , Aguiar Evandro G. de , Naves Marcelo D. , Abreu José A. S. , Abreu Sheila R. L. 
Published: August 2008

AbstractDenture stomatitis presents as a chronic disease in denture‐bearing patients, especially under maxillary prosthesis. Despite the existence of a great number of antifungal agents, treatment failure is observed frequently. Propolis, a natural bee product, possesses well‐documented antifungal and anti‐inflammatory activities. The purpose of this study was to evaluate the clinical efficacy of a new Brazilian propolis gel formulation in patients diagnosed with denture stomatitis. Thirty complete‐denture wearers with denture stomatitis were enrolled in this pilot study. At baseline, clinical evaluation was performed by a single clinician and instructions for denture hygiene were provided. Fifteen patients received Daktarin®(Miconazole gel) and 15 received Brazilian propolis gel. All patients were recommended to apply the product four times a day during one week. Clinical evaluation was repeated by the same clinician after treatment. All patients treated with Brazilian propolis gel and Daktarin®had complete clinical remission of palatal edema and erythema. This new Brazilian propolis gel formulation had efficacy comparable to Daktarin®and could be an alternative topical choice for the treatment of denture stomatitis. Copyright © 2008 John Wiley & Sons, Ltd.
Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes
Authors: Illouz Severine , Alexandre Eliane , Pattenden Clare , Mark Louise , Bachellier Philippe , Webb M'Balu , Berry David , Dennison Ashley , Richert Lysiane 
Published: August 2008

AbstractCurcumin (CUR) is a major component of a dietary spice derived from the roots of Curcuma longa. It has strong antioxidant activities and hepatoprotective properties. Primary human hepatocytes are clinically used in transplantation or in bioartificial liver devices for the treatment of patients with liver failure. Fresh and cryopreserved hepatocytes are also used in vitro for the study of drugs in pharmacotoxicology. We aimed to assess whether CUR could improve human liver cell viability and prevent oxidative damage responsible for large cell loss during cell preparation. Our study showed beneficial effects of CUR (25 µM) on freshly isolated human hepatocytes, increasing significantly metabolic activity of viable attached cells when seeded with CUR for 24 h. However CUR added during the cell isolation process did not have any significant impact on cell isolation outcomes or on cryopreservation outcomes. Conversely, CUR added during the thawing of frozen cells had a negative effect on the cell attachment capacity of hepatocytes that were cryopreserved in the presence or absence of CUR. In conclusion, although having positive effects on viability and challenge of oxidative stress on cultured human hepatocytes, CUR had no beneficial effect on cell isolation or cryopreservation outcomes. Copyright © 2008 John Wiley & Sons, Ltd.
Gallotannin ameliorates the development of streptozotocin‐induced diabetic nephropathy by preventing the activation of PARP
Authors: Chandak Prakash Gopaldas , Gaikwad Anil Bhanudas , Tikoo Kulbhushan 
Published: August 2008

AbstractPoly(ADP‐ribose) polymerase (PARP) is known to be activated under conditions of oxidative stress and/or radiation exposure. The role of this enzyme has been well demonstrated in the streptozotocin (STZ) induced model of diabetes. Inhibition of PARP by specific inhibitors is known to prevent the development of STZ induced diabetic nephropathy by reduction in oxidative stress induced apoptosis. This study shows for the first time the role of poly(ADP‐ribose) glycohydrolase (PARG) inhibitors as an alternative approach for inhibition of PARP. Gallotannin (20 mg/kg/day, i.p.) treatment for 4 weeks led to a significant reduction in the levels of plasma creatinine which is a well known marker for diabetic nephropathy. Treatment with gallotannin resulted in protection up to a certain level of glomerular damage, suggesting compensatory glomerular hypertrophy. As a PARG inhibitor gallotannin treatment also showed protection in PARP cleavage which is a hallmark for apoptotic cell death signifying the protective role of gallotannin in cell death signaling. Copyright © 2008 John Wiley & Sons, Ltd.
Neuroprotective effect of genistein in 6‐hydroxydopamine Hemi‐parkinsonian rat model
Authors: Baluchnejadmojarad Tourandokht , Roghani Mehrdad , Nadoushan Mohammad Reza Jalali , Bagheri Maryam 
Published: August 2008

AbstractA large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson's disease (PD). Phytoestrogens such as genistein have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether genistein administration at a high dose would attenuate behavioral and structural abnormalities in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6‐hydroxydopamine (6‐OHDA, 12.5 µg/5 µL of saline‐ascorbate)‐lesioned rats were intraperitoneally pretreated with a single and high dose of genistein (10 mg/kg) 1 h before surgery. Apomorphine‐induced rotations and the number of Nissl‐stained neurons in the substantia nigra pars compacta (SNC) were counted after 2 weeks. Genistein administration could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6‐OHDA toxicity. Genistein administration has a protective effect against 6‐OHDA toxicity. Copyright © 2008 John Wiley & Sons, Ltd.