bluuebunny/crossref_metadata_2025_split huggingface dataset:
The realisation of text coherence trough conceptual metaphors in the Albanian and English language
Authors: Idrizi Faik , Çeliku Arbër 
Published: April 2024

‘Coherence’ as a linguistic notion is one of the seven basic criteria of textuality (Dressler 1981). There are many linguistic elements through them coherence can be achieved, but the focus of this article will be the conceptual metaphor in the Albanian language as an specific element, which is not to find in any other language. The reason of conducting such contrastive research consists of three guidelines: First, although Albanian and English belong to the same language family: Indo-European, also they are inflectional languages, but they have their own mechanism expressing linguistic phenomena. Secondly, the Albanian language, building an independent group within the Indo-European family group, provides some differences in the morpho-syntactic level compared to German and English as languages of the same group. Third, metaphors are not only a linguistic phenomenon, but, first of all, a cultural one. There is a big difference between Albanian and English. This article focuses not only to express the linguistic differences of the realization of text coherence trough metaphors in Albanian and English, but also builds an methodological-didactic frame, especially for learners of both languages to avoid mistakes in the process of text constitution in these languages.
Modern technologies in the development of higher education teachers’ professional competence
Authors: Manchenko T. V. , Guchetl I. N. 
Published: April 2024

The relevance of the research. The current stage of the historical development of the world community is characterized by the acceleration of scientific, technical and social progress, the large-scale dissemination of new ideas and technologies. Therefore, the reproduction of knowledge carriedout on an innovative basis is relevant and has an increasing impact on the rate of economic growth. The problem statement. The modern education system is gradually beginning to fully use theresources of the competency-based approach. In vocational education this approach is the conceptual basis for the implementation of an innovation system. The problem of the research is to identify the features of the formation of professional competence of higher education teachers. The purpose of the article is to substantiate modern technologies for developing the professional competence of vocational education teachers to increase their readiness to train future specialists on innovative principles. The research methods used are theoretical analysis of scientific literature on the research problem; study of regulatory documents in the field of education; analysis and synthesis; systematization and generalization; survey. The results and key conclusions. The need for continuous professional development of teachers based on innovative principles and updating of the problem under consideration has been identified. The use of modern pedagogical technologies of distance learning, project-based learning and production technologies for the formation of professional competence of higher education teachers, as well as modern forms of training future qualified specialists, have been justified.
Educational models and technologies in the era of digital transformation
Authors: Salova T. L. 
Published: April 2024

At present digital transformation of the society faces the problem of a shortage of a highly qualified personnel - specialists in the field of the latest information technologies, intellectual scientists with a high-quality fundamental education. The solution to this problem lies in the introduction of new educational models and technologies. The purpose of the research is to study the strategy for the formation of a new conceptual scheme of modern education. It has been emphasized that two leading educational models are currently being successfully implemented and complement each other: the classical model of «completed» education with the basic principle of «education once and for life», covering the need of the society for the generation and dissemination of knowledge, as well as the storage of cultural ideals, and the second model, called the «lifelong education model», which meets the principle of «lifelong education», corresponding to the rapid changes in technology and the nature of digital transformations of the society. The article pays special attention to new educational technologies such as: 1) analytical technologies, which are based on the analysis of big data from educational institutions in real time; 2) adaptive (or intellectual) learning, which is based on the principles of personalization of learning and building an individual educational trajectory; 3) Smart education, using learning tools in an interactive educational environment with elements of distance and mobile education. The methodological basis of the research is a systematic approach and general methods of scientific knowledge, such as analysis, synthesis, generalization. The relevance of the topic is associated with increased attention to the problem of matching the quality of the Russian education with the promising tasks of the digital transformation of the Russian society. Key conclusion. A high professional level of the personnel reserve, which will be able to practically implement state digitalization programs, is possible and is associated with the construction of a new concept of modern education.
Development of commodity franchising models in modern socio-economic conditions
Authors: Филатов В.В. , Минайченкова Е.И. , Полянская О.А. , Токарева М.В. 
Published: April 2024

В статье рассмотрено развитие моделей товарного франчайзинга в современных социально-экономических условиях. Проведенный анализ развития моделей товарного франчайзинга на международном рынке трех иностранных брендов («L'Occitane en Provence», «Truccabocca» и «Mango») показал, что на успех компании в продаже франшиз влияют не только выгодные условия сделки, но и менталитет страны, которую они представляют общественности. Показано, что товарный франчайзинг в России на данном этапе находится на стадии развития, хотя потенциальные возможности его внедрения достаточно широки. Также можно сделать вывод о довольно грамотном функционировании представителей российского бизнеса в форме товарного франчайзинга. Именно данная форма бизнеса позволяет получить возможность использовать уже отработанные и оправдавшие себя технологии, известную марку, возможность обучаться и получать необходимые консультации. Все эти возможности могут предоставить те, кто уже имеет опыт, знания, обладает технологическими секретами предпринимателей, т.е. располагает капиталом не материальным, но весьма ценным и эффективным, если его правильно использовать. Грамотное использование всех сторон товарного франчайзинга позволит успешно вести бизнес.
The article considers the development of commodity franchising models in modern socio-economic conditions. The analysis of the development of commodity franchising models in modern socio-economic conditions on the international market of three foreign brands ("L'Occitane en Provence", "Truccabocca" and "Mango") showed that the success of the company in selling franchises is influenced not only by favorable terms of the transaction, but also by the mentality of the country they represent to the public. It is shown that commodity franchising in Russia is currently under development, although the potential for its implementation is quite wide. It is also possible to draw conclusions about the fairly competent functioning of representatives of Russian business in the form of commodity franchising. It is this form of business that allows you to get the opportunity to use already proven and proven technologies, an already well-known and popular brand, the opportunity to study and receive the necessary consultations along the way. All these opportunities can be provided by those who already have experience, knowledge, and technological secrets of entrepreneurs, i.e. they have capital that is not material, but very valuable and effective if used correctly. Proper use of all aspects of commodity franchising will allow you to successfully conduct business in the right direction.
Improving national risk management standards for innovation risk management
Authors: Шаповалова В.Н. , Горчак М.О. 
Published: April 2024

В статье исследованы экономические и управленческие аспекты управления рисками инновационного предпринимательства. Раскрыты особенности инновационной деятельности с учетом государственных электронных торгов. Выявлены возможности и угрозы инновационной деятельности в условиях электронной системы торговли. Показано, что действующие национальные стандарты менеджмента рисков, в том числе рисков инновационного предпринимательства, нуждаются в переосмыслении. Предлагается несколько вариантов совершенствования моделей менеджмента риска инноваций в условиях бюджетного финансирования инноваций, в условиях небюджетного финансирования инноваций, в условиях государственно-частного партнерства.
The article examines the economic and managerial aspects of risk management of innovative entrepreneurship. The features of innovation activity, taking into account the state electronic trading, are disclosed. The possibilities and threats of innovative activity in the context of an electronic trading system are identified. It is shown that the current national standards of risk management, including the risks of innovative entrepreneurship, need to be rethought and revised. Several options are proposed for improving innovation risk management models in terms of budget financing of innovations, in terms of non-budget financing of innovations, in terms of public-private partnership.
Research of the features of the labor market of the Vladimir region
Authors: Быкова М.Л. 
Published: April 2024

В статье приводится исследование трудовых ресурсов как фактора производства на территории Владимирской области. Важность грамотного управления кадровым потенциалом территорий признана отечественными и зарубежными авторами. В современных условиях, сопряженных с высокой степенью риска и неопределенности, грамотное управление производственными процессами на основе эффективного использования кадровых возможностей представляется актуальным инструментом преодоления текущих вызовов и проблем. Отмечается важность исследования трудового потенциала региона в условиях цифровой трансформации общества. Происходящее усложнение трудовых функций обусловливает появление новых требований к персоналу. Проанализировано, как меняются основные показатели, характеризующие изменения на рынке труда Владимирской области, построена модель изменения среднемесячной заработной платы в регионе с учетом сезонной компоненты, а также рассмотрено влияние уровня безработицы на величину валового производства в регионе. Представленные расчеты свидетельствуют о необходимости грамотного управления трудовым потенциалом и могут быть использованы при построении курса развития Владимирской области.
The article presents a study of labor resources as a factor of production in the territory of the Vladimir region. The importance of competent management of the human resources potential of the territories is recognized by domestic and foreign authors. In modern conditions associated with a high degree of risk and uncertainty, competent management of production processes based on the effective use of human resources is an important tool for overcoming current challenges and problems. It should also be noted the importance of studying the labor potential of the region in the context of the digital transformation of society. The ongoing complication of labor functions leads to the emergence of new requirements for personnel. The article analyzes how the main indicators characterizing changes in the labor market of the Vladimir region change, a model of changes in the average monthly salary in the region is constructed, taking into account the seasonal component, and the influence of the unemployment rate on the gross output in the region is considered. The presented calculations indicate the need for competent management of labor potential and can be used in building the course of development of the Vladimir region.
Modern state of science in Russia: analysis and perspectives for the development of scientific and industrial cooperation
Authors: Садыков С.Ф. , Соколов А.П. , Аблязина С.М. 
Published: April 2024

В статье представлены результаты комплексного анализа научного потенциала России в сопоставлении с зарубежными странами на фоне геополитических напряжений и введенных санкций. Выявлено отставание Российской Федерации от ведущих мировых экономик в аспекте инновационной активности бизнес-сектора, подчеркивается критическая необходимость стимулирования инновационных инициатив. Успех технологического развития страны значительно зависит от эффективности взаимодействия ключевых стейкхолдеров: вузов, научных учреждений, бизнес-сообщества и государственных структур. Стратегическое партнерство и системное взаимодействие между этими секторами выступают фундаментальным условием для ускорения инновационных процессов. Результаты исследования также подтверждают необходимость углубления сотрудничества между университетами и предприятиями в рамках научно-производственной кооперации.
The article presents the results of a comprehensive analysis of Russia’s scientific potential in comparison with foreign countries against the background of geopolitical tensions and imposed sanctions. The article reveals that the Russian Federation lags behind the world’s leading economies in terms of innovation activity of the business sector, emphasizing the critical need to stimulate innovation initiatives. The success of technological development of the country significantly depends on the effectiveness of interaction between key stakeholders: universities, scientific institutions, business community and government agencies. Strategic partnership and systemic interaction between these sectors is a fundamental condition for the acceleration of innovation processes. The results of the study also confirm the need to deepen cooperation between universities and enterprises in the framework of scientific and industrial cooperation.
Features and ways of effective management based on modeling macroeconomic imbalances
Authors: Кириченко А.О. , Золкин А.Л. , Гиршевич О.Л. , Атаева Л.Б. 
Published: April 2024

Исследование проблем макроэкономической нестабильности и разработка стратегий ее преодоления остаются в центре внимания научного сообщества и практического применения в экономической политике. В рамках данного исследования поднимается задача анализа макроэкономических индикаторов, таких как уровень занятости населения и безработицы, объем и динамика роста валового внутреннего продукта, ставка рефинансирования, а также другие важные параметры. Особое внимание уделяется построению и анализу экономических моделей, которые позволяют систематизировать полученные данные и выявить взаимосвязи между различными макроэкономическими факторами и их влиянием на общее состояние экономики на разных уровнях. Статья затрагивает теоретические и практические аспекты экономического моделирования макроэкономических показателей, определяя ключевые взаимосвязи между индикаторами и факторами влияния на макроуровне. Рассмотрение моделей проводится через различные методы представления: от графического и математического, до словесного описания с использованием уравнений, что позволяет всесторонне анализировать и интерпретировать макроэкономические процессы.The study of the problems of macroeconomic instability and the development of strategies to overcome it remain in the focus of attention of the scientific community and practical application in economic policy. Within the framework of this study, the task of analyzing macroeconomic indicators such as the level of employment and unemployment, the volume and dynamics of gross domestic product growth, the refinancing rate, as well as other important parameters is raised. Special attention is paid to the construction and analysis of economic models that allow us to systematize the data obtained and identify the relationship between various macroeconomic factors and their impact on the overall state of the economy at different levels. The article touches on the theoretical and practical aspects of economic modeling of macroeconomic indicators, identifying the key relationships between indicators and factors of influence at the macro level. The models are considered through various methods of representation: from graphical and mathematical, to verbal description using equations, which allows a comprehensive analysis and interpretation of macroeconomic processes.
Optimization of transaction costs as a factor in increasing the competitiveness of enterprises
Authors: Костенко С.Г. 
Published: April 2024

В статье анализируется роль оптимизации транзакционных издержек в повышении конкурентоспособности предприятий. Для повышения конкурентоспособности важно знать о существовании транзакционных издержек, их формировании, факторах, определяющих их стоимость, связи с понесенными рисками и т. д. На практике низкая осведомленность о транзакционных издержках затрудняет эффективный анализ, хотя предприятия могут интуитивно предпринимать определенные действия в этом отношении. Лучшие возможности оптимизации затрат появляются при их сознательном и продуманном формировании для повышения конкурентоспособности.
The article analyzes the role of optimization of transaction costs in increasing the competitiveness of enterprises. To increase competitiveness, it is important to know about the existence of transaction costs, their formation, the factors determining their value, the relationship with the risks incurred, etc. In practice, low awareness of transaction costs makes it difficult to effectively analyze, although enterprises can intuitively take certain actions in this regard. The best opportunities for cost optimization appear when they are consciously and thoughtfully formed to increase competitiveness.
Identification of CRISPR/Cas12a (Cpf1) guideRNA Sequence Targeting the Mitochondrial DNA D-loop Region in Wild Pig (Sus scrofa) Through Homology Difference and Mismatch Analysis
Authors: Zein Muhammad Ihda Hamlu Liwaissunati , Hardianto Ari , Irkham Irkham , Hartati Yeni Wahyuni 
Published: April 2024

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) or CRISPR-associated (Cas) System has become a major gene editing tool. Gene editing with CRISPR requires the Cas protein and the corresponding guide RNA (gRNA). However, low cleavage efficiency and off-target effects can impede the application of the CRISPR/Cas system. Therefore, the determination of specific gRNAs is essential. In biosensor applications, CRISPR/Cas12a can enhance specificity and sensitivity in identifying target genes due to the trans-cleavage activity of Cas12a (Cpf1). The mtDNA D-loop sequence is the most variable part of mtDNA, making it suitable for distinguishing between species. Consequently, the objective of this study was to determine the gRNA sequence of the D-loop of wild pig mtDNA in silico. Candidate gRNAs were predicted using the Benchling application with the assistance of the GenBank database. The gRNA candidates were subsequently subjected to a homology difference analysis using BLAST nucleotide and a mismatch test using Jalview. Among several candidates, candidate 1 was selected as the best option, with an Off-target value of 99.8. The homology difference analysis against competitors and the mismatch test against the Sus genus resulted in high E-values and high percentage values, respectively. This suggests that the candidate will not recognize other species but can detect members of the Sus scrofa species. These gRNA candidates can be selectively and sensitively applied to biosensors for the detection of meat adulteration.
HIGHLIGHTS

The D-loop exhibits high variability, make it useful for distinguishing between species
gRNA as an enabler of CRISPR/Cas12a to identify the target and initiate cleavage activity
The candidate 1 was selected with the sequence 5'-GAT TGT CGT GCC GGA TCA TGA GTT-3'
The application of this strategy is aimed at determining the halal status of food products
The application will encompass both quantitative and qualitative aspects

GRAPHICAL ABSTRACT
Purification of IgY Anti-SARS-CoV-2-Chicken Nucleocapsid and Elimination of Its Low-temperature Storage-induced Aggregates
Authors: Idar Idar , Yusuf Muhammad , Anshori Jamaludin Al , Subroto Toto 
Published: April 2024

Even though the COVID-19 pandemic has ended, the virus is still circulating. It is important to detect it, as its symptoms are similar to other endemic diseases, e.g. dengue fever. Detection can be done using birds’ specific immunoglobulin Y, IgY Anti-SARS-CoV-2-Chicken Nucleocapsid (IgY anti-N), obtained by immunising chickens with the SARS CoV2 nucleocapsid protein. However, IgY purification requires further research, as commonly used ligands are unsuitable. Another common problem with IgY anti-N is aggregation, even when stored at low temperatures. Thus, this research aims to purify IgY anti-N and eliminate low-temperature storage-induced aggregates. In this study, polyethene glycol (PEG) was used for delipidation. The resulting IgY was divided into 2 parts, one of which was stored at 4 °C and purified within the next 1 or 2 days (labelled as IgY 4 °C), while the other was stored at −20 °C and purified within a period of 1 or 2 years (labelled as IgY −20 °C). The next step involved purifying both samples using hydrophobic chromatography and sequential anion exchange. Peaks resulting from the hydrophobic column were analyzed using High-Performance Liquid Chromatography (HPLC) and Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE). Another purification result was analysed using PAGE. The migration of each separation step result was observed using native, denaturing and non-reducing PAGE. The study showed, qualitatively, that using two-step chromatographic techniques, hydrophobic interaction and ion exchange chromatography significantly increased the purity of IgY during purification. Additionally, the results demonstrated that hydrophobic chromatography purifies IgY and removes aggregates that may arise from storage. Moreover, similar to immunoglobulin G, IgY anti-N was found to have an uncommon migration in native PAGE compared to other proteins.
HIGHLIGHTS

PEG precipitation for delipidation of egg yolk containing IgY
Two-step chromatographic method for IgY purification: hydrophobic interaction and ion exchange
Hydrophobic interaction chromatography can purify and also remove the aggregate of the IgY sample
Native PAGE cannot be used to calculate antibody molecular weight

GRAPHICAL ABSTRACT