bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of Luminescence from Lanthanide Metal–Organic Frameworks by Ytterbium and Calcium Doping: Application to Photonic Barcodes and Fingerprint Detection
Authors: Chen Jiabo , Li Musen , Sun Renrui , Xie Yao , Reimers Jeffrey R. , Sun Lining 
Published: March 2024

AbstractEmission from metal–organic frameworks (MOFs) made from Eu3+ and 1,3,5‐benzenetricarboxylic acid (BTC) is enhanced eightfold by doping with Y3+ and Ca2+ ions. The Ca2+ ions are shown to substitute into the MOFs, and the MOFs structure is shown to be retained at high Y3+ doping levels. The emission enhancement is shown to be associated with variations in the local electric field at the Eu3+ centers in the MOFs. Calculations indicate that the HOMO and LUMO levels vary considerably with both Y3+ doping and with low‐level Ca2+ doping. These then modulates Eu3+ concentration quenching, ligand‐metal energy transfer processes, and the local electric field at the Eu3+ centers, qualitatively accounting for the primary observed features. For UV excitation (250, 295, and 393 nm, respectively), the greatest emission enhancement comes from the doped MOFs with 10% Eu3+, 89% Y3+, and 1% Ca2+. In a photonic barcode application, the doped MOFs are shown to facilitate increased information storage density, and in a fingerprinting application, they are displayed to lead to higher photostability and reduced materials demand.
Efficient Sn–Pb Mixed Perovskite Solar Cells Via Minimizing Solvent Oxidation
Authors: Ge Ciyu , Jiang Borui , Zhu Jiaxing , Zhang Peiyan , Ma Ruiqi , Yan Shuyu , Liu Zhiqiang , Shaker Ahmed , Salem Marwa S. , Luo Jiajun , Xu Ling , Yang JiaKuan , Li Zhaoyang , Song Haisheng , Chen Chao , Tang Jiang 
Published: March 2024

AbstractTin (Sn)–lead (Pb) mixed perovskite solar cells (PSCs) stand out as the optimal choice for the bottom subcell of the all‐perovskite tandem solar cells. One of the major challenges impeding the further enhancement of Sn–Pb mixed PSCs power conversion efficiency (PCE) is the easy oxidation of Sn2+ to Sn4+ and a large number of Sn vacancies in the perovskite films. In this work, the sources of Sn2+ oxidation in the perovskite precursor solution are systematically investigated, focusing on the oxidation state of raw materials, solvent‐dissolved oxygen, and solvent oxidizing ability. It is discovered that compared to the commonly used dimethyl sulfoxide (DMSO) solvent, N, N'‐Dimethylpropyleneurea (DMPU) exhibits a weaker oxidizing ability while forming excellent coordination with the perovskite precursor. Using a mixed solvent of N, N‐Dimethylformamide (DMF), and DMPU as the precursor solvent not only obviates the need for additional antioxidants but also demonstrates reduced oxidation susceptibility toward Sn–Pb mixed perovskite. Utilizing a gas‐assisted technique without anti‐solvents, high‐efficiency Sn–Pb mixed PSCs are fabricated. These findings not only deepen the understanding of the oxidation phenomena in Sn–Pb perovskite precursor solutions but also provide essential guidance for the scalable production of Sn–Pb mixed PSCs and tandem solar cells.
Exosome Isolation Using Chitosan Oligosaccharide Lactate‐1‐Pyrenecarboxylic Acid‐Based Self‐Assembled Magnetic Nanoclusters
Authors: Kim Minse , Song Chi‐Yeon , Lee Jin Sil , Ahn Yu‐Rim , Choi Jaewon , Lee Sang Hoon , Shin SoJin , Na Hee Jun , Kim Hyun‐Ouk 
Published: March 2024

AbstractExosomes are small extracellular vesicles that play a crucial role in intercellular communication and offer significant potential for a wide range of biomedical applications. However, conventional methods for exosome isolation have limitations in terms of purity, scalability, and preservation of exosome structural integrity. To address these challenges, an exosome isolation platform using chitosan oligosaccharide lactate conjugated 1‐pyrenecarboxylic acid (COL‐Py) based self‐assembled magnetic nanoclusters (CMNCs), is presented. CMNCs are characterized to optimize their size, stability, and interaction dynamics with exosomes. The efficiency of CMNCs in isolating exosomes is systematically evaluated using various analytical methods to demonstrate their ability to capture exosomes based on amphiphilic lipid bilayers. CMNC‐based exosome isolation consistently yields exosomes with structural integrity and purity similar to those obtained using traditional methods. The reusability of CMNCs over multiple exosome isolation cycles underscores their scalability and offers an efficient solution for biomedical applications. These results are supported by western blot analysis, which demonstrated the superiority of CMNC‐based isolation in terms of purity compared to conventional methods. By providing a scalable and efficient exosome isolation process that preserves both structural integrity and purity, CMNCs can constitute a new platform that can contribute to the field of exosome studies.
An AIE Controlled “Off‐On” Cu2+‐Sensitive Probe for Early Detection of Renal Fibrosis
Authors: Zhou Jie , Luo Fusui , Dong Xiaomeng , Ma Huili , Guan Min , Zhang Jin , Sun Yiwen , Feng Junfen 
Published: March 2024

AbstractEarly detection of renal fibrosis (RF) is very important given that it is irreversible when it progresses to the terminal stage. A key marker of RF pathogenesis is activation of myomyofibroblasts, and its targeted imaging may be a promising approach for early detection of RF, but no study has directly imaged activation of renal myomyofibroblasts. Cu2+ plays a major role in the fibrotic activity of myofibroblasts. Herein, inspired by that Cu2+ can complex with bovine serum albumin (BSA), BSA‐Ag2S quantum dots (QDs) with aggregation‐induced emission (AIE) property are synthesized. Then BSA‐Ag2S QDs are modified by chitosan (CS) with renal targeting and hyaluronic acid (HA) with myofibroblast targeting to obtain the AIE assay system (QDs@CS@HA). The system is simple to synthesize, and produces a rapid NIR fluorescence signal turn‐on response and a low detection limit of 75 × 10−9 m to Cu2+. In addition, cellular and animal experiments have shown that QDs@CS@HA has good biosafety and cell‐targeted imaging capability for RF. Based on the successful application of QDs@CS@HA and the mechanism of RF progression in early RF detection, it is expected that QDs@CS@HA may detect RF before the appearance of clinical symptoms.
Minimally Invasive Delivery of Percutaneous Ablation Agent via Magnetic Colloidal Hydrogel Injection for Treatment of Hepatocellular Carcinoma
Authors: Wu Wen‐Shu , Yan Xu , Chen Sheng , Du Yaxin , Hu Jinlong , Song Yonghong , Zha Zhengbao , Xu Yun‐Jun , Cao Baoqiang , Xuan Shou‐Hu , Liu Xingyu , Chen Bing , Dong Liang , Lu Yang , Yu Shu‐Hong 
Published: March 2024

AbstractPercutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means of target‐delivering heat. Conventional thermal ablation methods, such as radiofrequency or microwave ablation, to a certain extent, are subjected to extended ablation time as well as biosafety risks of unwanted overheating. Given its effectiveness and safety, percutaneous thermotherapy gains a fresh perspective, thanks to magnetic hyperthermia. In this respect, an injectable‐ and magnetic‐hydrogel‐construct‐based thermal ablation agent is likely to be a candidate for the aforementioned clinical translation. Adopting a simple and environment‐friendly strategy, a magnetic colloidal hydrogel injection is introduced by a binary system comprising super‐paramagnetic Fe3O4 nanoparticles and gelatin nanoparticles. The colloidal hydrogel constructs, unlike conventional bulk hydrogel, can be easily extruded through a percutaneous needle and then self‐heal in a reversible manner owing to the unique electrostatic cross‐linking. The introduction of magnetic building blocks is exhibited with a rapid magnetothermal response to an alternating magnetic field. Such hydrogel injection is capable of generating heat without limitation of deep penetration. The materials achieve outstanding therapeutic results in mouse and rabbit models. These findings constitute a new class of locoregional interventional thermal therapies with minimal collateral damages.
Moiré Pattern Controlled Phonon Polarizer Based on Twisted Graphene
Authors: Qin Zihao , Dai Lingyun , Li Man , Li Suixuan , Wu Huan , White Katherine E. , Gani Gilad , Weiss Paul S. , Hu Yongjie 
Published: March 2024

AbstractTwisted van der Waals materials featuring Moiré patterns present new design possibilities and demonstrate unconventional behaviors in electrical, optical, spintronic, and superconducting properties. However, experimental exploration of thermal transport across Moiré patterns has not been as extensive, despite its critical role in nanoelectronics, thermal management, and energy technologies. Here, the first experimental study is conducted on thermal transport across twisted graphene, demonstrating a phonon polarizer concept from the rotational misalignment between stacked layers. The direct thermal and acoustic measurements, structural characterizations, and atomistic modeling, reveal a modulation up to 631% in thermal conductance with various Moiré angles, while maintaining a high acoustic transmission. By comparing experiments with density functional theory and molecular dynamics simulations, mode‐dependent phonon transmissions are quantified based on the angle alignment of graphene band structures and attributed to the coupling among flexural phonon modes. The agreement confirms the dominant tuning mechanisms in adjusting phonon transmission from high‐frequency thermal modes while having negligible effects on low‐frequency acoustic modes near Brillouin zone center. This study offers crucial insights into the fundamental thermal transport in Moiré structures, opening avenues for the invention of quantum thermal devices and new design methodologies based on manipulations of vibrational band structures and phonon spectra.
Unveiling Electric Field Induced Ultrafast Charge Transfer Dynamics and Photoresponse Enhancement in Gold‐Interlayered Bi2Se3
Authors: Saini Saurabh K. , Sharma Prince , Gautam Sudhanshu , Verma Sahil , Kumar Kapil , Gupta Arshi , Tawale J. S. , Husale Sudhir , Kushvaha Sunil Singh , Walia Sumeet , Singh Rajiv Kr. , Bano Sahiba , Mori Takao , Kumar Mahesh 
Published: March 2024

AbstractIn the realm of optoelectronic applications, the incorporation of a metal interlayer between layers of a topological material holds significant potential. The interlayer introduces benefits such as improved charge transfer efficiency, tunable band alignment, plasmonics effect, and enhanced light‐matter interactions, paving the way for more efficient and versatile optoelectronic devices. This work explores the incorporation of gold between Bi2Se3, resulting in an enhancement in the response time of photoresponse of interlayered systems (Bi2Se3‐Au‐Bi2Se3). The introduction of a gold interlayer between Bi2Se3 significantly influences the overlayer structure, crystallinity, crystallite size, and even phonon behavior. Moreover, the responsivity of the interlayered device at a bias (2 V) is found to have high responsivity with fast response and decay time (τr = 0.1 ms, and τd = 24 ms of interlayered systems) as compared to intrinsic Bi2Se3(τr = 0.6 ms, and τd = 28 ms). This change is attributed to the bandgap alteration of the Bi2Se3/Au interface, which is monitored through transient spectroscopy performed at different electric biases. This study suggests that incorporating a gold interlayer holds potential benefits for various optoelectronic applications.
Metamaterial Engineering for Superior HgTe cQD Photodetector Performance
Authors: Schwanninger Raphael , Nashashibi Shadi , Yarema Olesya , Koepfli Stefan M. , Fedoryshyn Yuriy , Wood Vanessa , Leuthold Juerg 
Published: March 2024

AbstractHighly responsive, low noise, and inexpensive photodetectors that operate in the mid‐infrared (MIR) wavelength regime are in high demand for applications ranging from fundamental science to large scale industries. However, simultaneously achieving all this in one device architecture is very challenging. In this work, mercury telluride (HgTe) colloidal quantum dot (cQD) based photodetectors are systematically improved by the introduction of new metamaterial designs. The new designs are found by utilizing simulations. Thereby the structures are optimized to increase the responsivity and simultaneously decrease the noise spectral current density. This is achieved by focusing on improving the photogenerated charge carrier collection efficiency while reducing the active material volume without altering the near unity absorption. A standard metamaterial perfect absorber architecture based on disc resonators is used as a starting point for the optimization process. By optimizing the carrier extraction through contact engineering, resulting in a narrow slot metamaterial, an overall ≈13‐fold responsivity and ≈345‐fold detectivity increase is achieved. The final metamaterial design reaches a responsivity of 16.2 A W−1 and detectivity of 6×108 Jones at a wavelength of 2710 nm. The analysis therefore provides a route to improve the responsivity and noise characteristics of mid‐infrared photodetectors based on cost‐efficient colloidal quantum dots.
Gold‐Catalyzed Tandem Oxidation‐Migration of 3‐Propargyl Indoles: Synthesis of α‐Indol‐3‐yl α,β‐Unsaturated Carbonyls
Authors: Renedo Lorena , Álvarez Estela , Solas Marta , Suárez‐Pantiga Samuel , Fernández‐Rodríguez Manuel A. , Sanz Roberto 
Published: March 2024

Abstractα‐Indol‐3‐yl α,β‐unsaturated carbonyl compounds are synthesized from 3‐propargyl indoles, obtained by direct propargylation of indoles, via a gold‐catalyzed tandem oxidation‐1,2‐indole migration reaction in the presence of pyridine N‐oxides. Fine‐tuning of the catalyst and oxidant enables the reaction of 3‐propargyl indoles bearing different substituents. The order of oxidation and indole migration is determined by the terminal or internal nature of the alkyne moiety. In addition, the process can be coupled with additional reactions, allowing an increase in molecular complexity or the design of more elaborated tandem reactions. In this sense, indole derivatives bearing an alkenyl substituent at the alkyne position evolve through a gold‐catalyzed tandem oxidation‐1,2‐indole migration‐Nazarov cyclization producing α‐indolyl cyclopentenones.
Preparation of Hetero‐π‐Conjugated Compounds by Double Nucleophilic Addition to Haloalkynes and C−H Cyclization
Authors: Hata Takeshi , Tatsumi Yuta , Kanai Yuki , Takahashi Naoto , Shigeta Masayuki , Urabe Hirokazu 
Published: March 2024

AbstractWhen a mixture containing 1‐halo‐1‐alkyne, a dinucleophilic agent, and a base (Cs2CO3 or K3PO4) was heated in DMF, regio‐ and stereo‐selective nucleophilic addition of the dinucleophilic agent to the acetylenes occurred. This reaction yielded (Z,Z)‐bis(haloalkene), which subsequently underwent Pd‐catalyzed cyclization through C−H bond activation, resulting in the formation of two‐oxygen‐ or ‐nitrogen‐containing hetero‐π‐conjugated compounds. N‐(5‐Hydroxynaphthalen‐1‐yl)methanesulfonamide was treated with 2‐phenyl‐1‐chloroethyne followed by 1‐chloro‐1‐hexadecyne. After these reactions, Pd‐catalyzed double C−H cyclization was employed to produce 1H‐2‐phenyl‐7‐tetradecylbenzofuro[7,6‐g]indole. Notably, this compound transformed into a fan‐shaped structure at 86 °C and transitioned into a smectic A phase characterized by a layered structure.
Ruppert‐Prakash Reagent (TMSCF3)‐Catalyzed Chemoselective Esterification of Weinreb Amides
Authors: Miele Margherita , Castoldi Laura , Beccalli Egle , Pace Vittorio 
Published: March 2024

AbstractA straightforward TMSCF3‐catalyzed conversion of Weinreb amides into esters through the treatment with sodium alkoxides is reported. The procedure documents a genuine selectivity for the esterification of primary alcohols with Weinreb amides featuring diverse substitution pattern. The constitutive N‐methoxy fragment of these acylating agents is responsible for the unique reactivity they display, thus enabling to explore alkoxides as competent nucleophilic elements. The protocol is compatible with the fully transfer of stereochemical information embodied in the starting material, as well as, guarantees the preparation of pharmaceuticals. Mechanistic investigations revealed that under the adopted reaction conditions (NaOR, R primary) TMSCF3 does not release the trifluoromethyl (CF3−) anion – as occurs with tertiary alkoxides – but rather it catalytically activates the amidic bond.
An Efficient Low‐Cost Device for Sampling Exhaled Breath Condensate EBC
Authors: Khorshid Mehran , Bakhshi Sichani Soroush , Barbosa Estrada Dimna L. , Neefs Werner , Clement Alexander , Pohlmann Gerhard , Epaud Ralph , Lanone Sophie , Wagner Patrick 
Published: March 2024

AbstractWhile exhaled breath condensate EBC is not yet used in routine clinical diagnostics and disease monitoring, recent publications indicate that exhaled air and EBC contain a wide range of molecular biomarkers that are characteristic of various medical conditions. This includes evidently lung disorders such as asthma, COPD, and cystic fibrosis, but also diabetes and several types of cancer go along with specific biomarkers exhaled from the airways. In addition, EBC samples can be collected in a non‐invasive way and, due to their small volume, they can be easily stored frozen between collection and analysis. Several home‐made EBC‐collection systems for research purposes are documented in literature while there are also a few systems from commercial suppliers that are not yet certified as medical products. In this work, a novel collection device is presented in which the EBC is condensed and frozen inside stainless steel tubes, tightly surrounded by an aluminum cylinder that is precooled in a kitchen freezer. The device is low cost, easy to use by patients at home or in a clinic, and its collection efficiency of up to 500 µL min−1of respiration is on the high side.
Effect of the Substrate Materials in the Fabrication of an Electrode Based on Mixed Nickel‐Iron Oxide Electrocatalyst
Authors: Tsuji Yuuri , Fiorani Andrea , Einaga Yasuaki 
Published: March 2024

AbstractThe effect of different substrate materials in the fabrication of an electrode intended for use in the water oxidation reaction is investigated. The electrocatalyst is nickel‐iron oxide (NiFeOx) which is deposited by chronoamperometry on nickel, iron, titanium, and stainless steel substrates. The process of electrodeposition is optimized to achieve the lowest overpotential for the water oxidation reaction. The four electrodes are characterized by scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), and glow‐discharge optical emission spectroscopy (GDOES) to describe the effect of the substrate on the nature of the electrocatalyst layer. Electrochemical tests in 1 m NaOH are applied on the four electrodes to assess the stability and the retention of the electrocatalytic properties of the whole electrode. All electrodes show similar overpotential of ≈0.3 V at 10 mA cm−2 implying that the substrate do not affect the electrocatalytic activity of the NiFeOx. After use, the overpotential increases in a range of 30–50 mV for nickel, iron, and titanium substrates, while stainless steel retains the lowest overpotential with an increase of 10 mV. This limited variation can be the effect of smaller NiFeOx nanoparticles compared to other substrates. XPS analysis reveals that after galvanostatic electrolysis, the oxidation state of Fe shifts slightly from Fe(II) to Fe(III), likely Fe3O4 and Fe2O3, while NiO/Ni2O3 change partially to Ni(OH)2.
Remodeling of the Intra‐Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein‐Based Conduit
Authors: Wang Jia‐Yi , Yuan Ya , Zhang Shu‐Yan , Lu Shun‐Yi , Han Guan‐Jie , Bian Meng‐Xuan , huang Lei , Meng De‐Hua , Su Di‐Han , Xiao Lan , Xiao Yin , Zhang Jian , Gong Ning‐Ji , Jiang Li‐Bo 
Published: March 2024

AbstractPeripheral nerve injury (PNI) remains a challenging area in regenerative medicine. Nerve guide conduit (NGC) transplantation is a common treatment for PNI, but the prognosis of NGC treatment is unsatisfactory due to 1) neuromechanical unmatching and 2) the intra‐conduit inflammatory microenvironment (IME) resulting from Schwann cell pyroptosis and inflammatory‐polarized macrophages. A neuromechanically matched NGC composed of regenerated silk fibroin (RSF) loaded with poly(3,4‐ethylenedioxythiophene): poly(styrene sulfonate) (P:P) and dimethyl fumarate (DMF) are designed, which exhibits a matched elastic modulus (25.1 ± 3.5 MPa) for the peripheral nerve and the highest 80% elongation at break, better than most protein‐based conduits. Moreover, the NGC can gradually regulate the intra‐conduit IME by releasing DMF and monitoring sciatic nerve movements via piezoresistive sensing. The combination of NGC and electrical stimulation modulates the IME to support PNI regeneration by synergistically inhibiting Schwann cell pyroptosis and reducing inflammatory factor release, shifting macrophage polarization from the inflammatory M1 phenotype to the tissue regenerative M2 phenotype and resulting in functional recovery of neurons. In a rat sciatic nerve crush model, NGC promoted remyelination and functional and structural regeneration. Generally, the DMF/RSF/P:P conduit provides a new potential therapeutic approach to promote nerve repair in future clinical treatments.
PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics
Authors: Wu Bingchen , Castagnola Elisa , McClung Colleen A. , Cui Xinyan Tracy 
Published: March 2024

AbstractSubstantial evidence has shown that the Circadian Locomotor Output Cycles Kaput (Clock) gene is a core transcription factor of circadian rhythms that regulates dopamine (DA) synthesis. To shed light on the mechanism of this interaction, flexible multielectrode arrays (MEAs) are developed that can measure both DA concentrations and electrophysiology chronically. The dual functionality is enabled by conducting polymer PEDOT doped with acid‐functionalized carbon nanotubes (CNT). The PEDOT/CNT microelectrode coating maintained stable electrochemical impedance and DA detection by square wave voltammetry for 4 weeks in vitro. When implanted in wild‐type (WT) and Clock mutation (MU) mice, MEAs measured tonic DA concentration and extracellular neural activity with high spatial and temporal resolution for 4 weeks. A diurnal change of DA concentration in WT is observed, but not in MU, and a higher basal DA concentration and stronger cocaine‐induced DA increase in MU. Meanwhile, striatal neuronal firing rate is found to be positively correlated with DA concentration in both animal groups. These findings offer new insights into DA dynamics in the context of circadian rhythm regulation, and the chronically reliable performance and dual measurement capability of this technology hold great potential for a broad range of neuroscience research.
Systemic Administration of Cowpea Mosaic Virus Demonstrates Broad Protection Against Metastatic Cancers
Authors: Chung Young Hun , Zhao Zhongchao , Jung Eunkyeong , Omole Anthony O. , Wang Hanyang , Sutorus Lucas , Steinmetz Nicole F. 
Published: March 2024

AbstractThe key challenge in cancer treatment is prevention of metastatic disease which is therapeutically resistant and carries poor prognoses necessitating efficacious prophylactic approaches that prevent metastasis and recurrence. It is previously demonstrated that cowpea mosaic virus (CPMV) induces durable antitumor responses when used in situ, i.e., intratumoral injection. As a new direction, it is showed that CPMV demonstrates widespread effectiveness as an immunoprophylactic agent – potent efficacy is demonstrated in four metastatic models of colon, ovarian, melanoma, and breast cancer. Systemic administration of CPMV stimulates the innate immune system, enabling attack of cancer cells; processing of the cancer cells and associated antigens leads to systemic, durable, and adaptive antitumor immunity. Overall, CPMV demonstrated broad efficacy as an immunoprophylactic agent in the rejection of metastatic cancer.