bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory Effect of Acorus tatarinowii Nasal in Situ Gel on Acetylcholinesterase
Authors: Xie Wuyun , Li Jianxin , Zhang Wenhui , Sun Qingwen , Chen Liang 
Published: April 2024

Acorus tatarinowii was a traditional Chinese medicine used to treat neurological diseases such as epilepsy with significant effects. When the oral dosage is too large, it has potential neurotoxic effects. However, the toxicity mechanism is still unclear. In this study network pharmacology methods were used to explore the mechanism of neurotoxicity of Acorus tatarinowii. The results showed that 5 toxic components of Acorus tatarinowii were identified, involving 73 neurotoxic targets. Among them, AKT1, CASP3, PTGS2, ESR1, EGFR, HIF1A, GSK3B, MMP9, SRC, and CCND1 may be key targets for Acorus tatarinowii to exert neurotoxic effects; KEGG pathway analysis found that the neurotoxicity caused by Acorus tatarinowii may be mainly related to Pathways in cancer, Endocrine resistance, and Chemical carcinogenesis-receptor activation. It was found that Acorus tatarinowii may exert neurotoxic effects through multiple components and targets.
POTENCIAIS EFEITOS DOS PROBIÓTICOS NO DESENVOLVIMENTO DO MICROBIOMA INTESTINAL DE NEONATOS PREMATUROS
Authors: Raulino Júlia Maria de Holanda , Moura Claudia Schmidt , Rocha Lucas Henrique Figueiredo , Silva Larissa Soares , Barbosa Vitória Sahena Martins Souza , Militão Gabrielle Guerra , Schenk Fernanda Santos , Cruz Noan da , Joter Kelcione Pinheiro Lima , Gomes Patrick Gouvea 
Published: April 2024

Este artigo tem por objetivo abordar os potenciais efeitos dos probióticos no desenvolvimento do microbioma intestinal de neonatos prematuros. Trata-se de uma revisão integrativa da literatura, realizada nos materiais indexados na Biblioteca Virtual em Saúde (BVS): Medical Literature Analysis and Retrieval System Online (MEDLINE) e a Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS). Foram utilizados os Descritores em Ciências da Saúde (DeCS) em cruzamento com o operador booleano AND, da seguinte forma: “Probióticos” AND “Microbioma Gastrointestinal” AND “Recém-nascido Prematuro”. Após a aplicação dos critérios de elegibilidade foram selecionados 9 (nove) estudos para compor essa revisão. O microbioma intestinal desempenha um papel crucial na saúde geral do neonato. Contudo, a sua composição pode ser particularmente vulnerável em bebês prematuros devido a uma série de fatores, incluindo imaturidade do trato gastrointestinal e exposição a intervenções médicas. Desse modo, os probióticos têm emergido como uma ferramenta promissora para o desenvolvimento imunológico, metabólico e neural do neonato pré-termo. Ademais, cepas probióticas específicas, especialmente o Lactobacillus, Bifidobacterium, apresentaram-se como alternativas profiláticas para o desenvolvimento de complicações gastrointestinais. Portanto, os potenciais efeitos benéficos na promoção da saúde infantil oferecem perspectivas emocionantes para melhorar os resultados a longo prazo.
Integrability and convergence of modified sum under some generalized coefficient class in L1-metric
Authors: Nagpal Priyanka , Singh Karanvir 
Published: April 2024

The class Sr', a generalization of the class S' of Fourier coefficients is used to investigate the integrability and convergence of modified sum under L1-metric. The criterion for L1-Convergence of rth derivative of modified sum hn is also obtained under the same class of Fourier coefficients.
PROFIT-SEEKING VS INNOVATION
Authors: Soldak Myroslava , Cherevatskyi Danylo , Lypnytskyi Denys 
Published: April 2024

Карл Маркс обнаружил тенденцию к понижению нормы прибыли как общее явление, проявляющееся на фоне стремления отдельного капиталиста максимизировать собственную прибыль. По мнению К. Маркса, причина — в эволюции органического состава капитала, сопровождающейся уменьшением его переменной составляющей, используемой на покупку рабочей силы. Увеличение капиталоемкости и снижение численности занятых на единицу продукции определяют тенденцию к снижению нормы прибыли.
Целью данной работы является качественная оценка взаимосвязи между техническим ростом и экономическим благополучием угледобывающих предприятий. На основе изучения и учета опыта Великобритании, Германии, Украины, Польши, Австралии и США была выдвинута следующая идея: повышение уровня механизации производства приводит к снижению рентабельности добычи угля.
Ключевые слова : инновации, механизация, тенденция снижения нормы прибыли, угольная промышленность.
Entrenamiento para cirujanos plásticos con Apple Vision Pro
Authors: Sanchez-Martínez Diego , Gracia-Rios Daniela , Padilla-Rojas Julián , Diaz-Chaker William 
Published: April 2024

Apple Vision Pro (AVP) represents a cutting-edge tool that, thanks to its advanced immersive technology, innovative interface and multiple applications, allow the plastic surgeon and the resident to have an experience that reinforces traditional methods of education and interaction. The following article describes a basic guide to PVA with an academic approach mentioning the software and applications that are useful to practice surgeries, make consultations, study anatomy, among other functions that help the progress of traditional education methods and likewise have better results in patients.
Las Apple Vision Pro (AVP) representan una herramienta de vanguardia que, gracias a su avanzada tecnología inmersiva, su novedosa interfaz y sus múltiples aplicaciones, permiten al cirujano plástico y al residente tener una experiencia que refuerza los métodos de educación e interacción tradicionales. En el siguiente artículo se describe una guía básica de las AVP con un enfoque académico mencionando el software y las aplicaciones que son de utilidad para practicar cirugías, realizar consultas, estudiar anatomía, entre otras funciones que ayuden al progreso de los métodos de educación tradicional y de la misma forma tener mejores resultados en los pacientes.
ФОРМУВАННЯ КРЕАТИВНОЇ ОСОБИСТОСТІ УЧНЯ НУШ ЧЕРЕЗ УРОКИ СЛОВЕСНОСТІ
Authors: Шавлова Людмила Валеріївна 
Published: April 2024

Автор розглядає вплив уроків української словесності у Новій українській школі (НУШ) на формування креативної особистості учнів. Дослідження фокусується на методиках, прийомах та підходах, спрямованих на стимулювання творчого мислення та розвиток уяви учнів під час уроків української літератури. Стаття пропонує практичні поради для вчителів щодо побудови уроків, які сприяють розвитку креативних здібностей учнів у контексті НУШ.
The Roman merchant ship sail plan: steering a windward passage.
Authors: Davey Christopher J. 
Published: April 2024

Two papers about the introduction of the spritsail during the Roman period in previous editions of Buried History are updated with additional references and hypotheses. A revised interpretation of Problem 7 in the Aristotelian corpus Mekhanika is given but the foregoing proposition that the introduction of spritsails made sailing to windward routine for Roman merchant sailing ships is retained. It is suggested that extremes of wind strength were the main inhibitors of windward sailing because it reduced boat speed, which in turn diminished lateral resistance and increased leeway.
COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas
Authors: Mohamed Amal H. , Eltyeb Ebtihal , Said Badria , Eltayeb Raga , Algaissi Abdullah , Hober Didier , Alhazmi Abdulaziz H. 
Published: April 2024

Background
COVID-19 and malaria cause significant morbidity and mortality globally. Co-infection of these diseases can worsen their impact on public health. This review aims to synthesize literature on the clinical outcomes of COVID-19 and malaria co-infection to develop effective prevention and treatment strategies.

Methods
A comprehensive literature search was conducted using MeSH terms and keywords from the start of the COVID-19 pandemic to January 2023. The review included original articles on COVID-19 and malaria co-infection, evaluating their methodological quality and certainty of evidence. It was registered in PROSPERO (CRD42023393562).

Results
Out of 1,596 screened articles, 19 met the inclusion criteria. These studies involved 2,810 patients, 618 of whom had COVID-19 and malaria co-infection. Plasmodium falciparum and vivax were identified as causative organisms in six studies. Hospital admission ranged from three to 18 days. Nine studies associated co-infection with severe disease, ICU admission, assisted ventilation, and related complications. One study reported 6% ICU admission, and mortality rates of 3%, 9.4%, and 40.4% were observed in four studies. Estimated crude mortality rates were 10.71 and 5.87 per 1,000 person-days for patients with and without concurrent malaria, respectively. Common co-morbidities included Diabetes mellitus, hypertension, cardiovascular diseases, and respiratory disorders.

Conclusion
Most patients with COVID-19 and malaria co-infection experienced short-term hospitalization and mild to moderate disease severity. However, at presentation, co-morbidities and severe malaria were significantly associated with higher mortality or worse clinical outcomes. These findings emphasize the importance of early detection, prompt treatment, and close monitoring of patients with COVID-19 and malaria co-infection.
Cultivating Resilience: Exploring Root Systems in Hydroponic Agriculture
Authors: Shivani . , Kaur Jasmeen , Sharma Pallavi , Shubham . , Kaushal Shilpa 
Published: April 2024

Hydroponic cultivation has emerged as a promising solution to address the challenges of conventional agriculture by offering efficient resource utilization and enhanced crop yields. At the core of this innovative farming technique lies the intricate relationship between plant roots and their surrounding environment. The success of hydroponic systems hinges upon the establishment of robust root systems, which serve as the anchors of growth in soilless mediums. Roots in hydroponic systems exhibit distinctive characteristics compared to those in traditional soil-based cultivation, with adaptations tailored to optimize nutrient uptake and water absorption in the absence of soil. Understanding these adaptations is crucial for maximizing the potential of hydroponic farming and overcoming limitations inherent in conventional agriculture. Additionally, various strategies for optimizing root performance within hydroponic systems are examined. Nutrient management techniques, such as nutrient film technique (NFT) and drip irrigation, play a vital role in ensuring adequate nutrient supply to support healthy root growth and overall plant development. Manipulation of root zone environments, including pH and oxygen levels, further enhances root function and nutrient uptake efficiency. These strategies contribute to the establishment of robust root systems capable of sustaining high levels of crop productivity in hydroponic environments. By shedding light on the significance of robust roots as the anchors of growth in hydroponic systems, this paper aims to inspire further exploration and innovation in sustainable agriculture practices, ultimately contributing to food security and environmental stewardship. Through a synthesis of current research findings, practical insights are provided to guide future advancements in hydroponic farming, fostering a more resilient and sustainable food production system.
Backbone Diversity Analysis in Catalyst Design
Authors: Maldonado Ana G. , Hageman Jos A. , Mastroianni Sergio , Rothenberg Gadi 
Published: February 2009

Abstractmagnified imageWe present a computer‐based heuristic framework for designing libraries of homogeneous catalysts. In this approach, a set of given bidentate ligand‐metal complexes is disassembled into key substructures (“building blocks”). These include metal atoms, ligating groups, backbone groups, and residue groups. The computer then rearranges these building blocks into a new library of virtual catalysts. We then tackle the practical problem of choosing a diverse subset of catalysts from this library for actual synthesis and testing. This is not trivial, since ‘catalyst diversity’ itself is a vague concept. Thus, we first define and quantify this diversity as the difference between key structural parameters (descriptors) of the catalysts, for the specific reaction at hand. Subsequently, we propose a method for choosing diverse sets of catalysts based on catalyst backbone selection, using weighted D‐optimal design. The computer selects catalysts with different backbones, where the difference is measured as a distance in the descriptors space. We show that choosing such a D‐optimal subset of backbones gives more diversity than a simple random sampling. The results are demonstrated experimentally in the nickel‐catalysed hydrocyanation of 3‐pentenenitrile to adiponitrile. Finally, the connection between backbone diversity and catalyst diversity, and the implications towards in silico catalysis design are discussed.
Performance features of Pt/BaO lean NOx trap with hydrogen as reductant
Authors: Clayton Robert D. , Harold Michael P. , Balakotaiah Vemuri 
Published: February 2009

AbstractThe performance of a model Pt/BaO/Al2O3 monolith catalyst was studied using H2 as the reductant. The dependence of product selectivities on operating parameters is reported, including the durations of regeneration and storage times, feed composition and temperature, and monolith temperature. The data are explained in terms of a phenomenological model factoring in the transport, kinetic, and spatio‐temporal effects. The Pt/BaO catalyst exhibits high cycle‐averaged NOx conversion above 100°C, generating a mixture of N2 and byproducts NH3 and N2O. The cycle‐averaged NOx conversion exhibits a maximum at about 300°C corresponding to the NOx storage maximum. The N2 selectivity exhibits a maximum at a somewhat higher temperature, at which point the NH3 selectivity exhibits a minimum. This trend conveys the intermediate role of NH3 in reacting with stored NOx. Both N2 and N2O are also formed during the storage steps from the oxidation of NHx species produced during the regeneration. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Nanoparticle‐Enhanced Fluorescence Imaging of Latent Fingerprints Reveals Drug Abuse
Authors: Wolfbeis Otto S. 
Published: February 2009

AbstractNo sweat! The sweat in a latent fingerprint (LFP) can contain orally ingested drugs and their metabolites. In a new method for drug detection, primary antibodies(Abs) against drug metabolites are conjugated to magnetic nanoparticles (NPs). The LFP is incubated with the NPs, excess particles removed, and the LFP treated with a fluorescently labeled secondary antibody. Fluorescence imaging then allows characterization.magnified image
Giant Pores in a Chromium 2,6‐Naphthalenedicarboxylate Open‐Framework Structure with MIL‐101 Topology
Authors: Sonnauer Andreas , Hoffmann Frank , Fröba Michael , Kienle Lorenz , Duppel Viola , Thommes Matthias , Serre Christian , Férey Gérard , Stock Norbert 
Published: February 2009

AbstractLarge, larger, …︁ Replacement of 1,4‐benzenedicarboxylate by 2,6‐naphthalenedicarboxylate in the MIL‐101 structure leads to an isoreticular mesoporous framework containing cages with diameters of 39 and 46 Å. High‐throughput methods are employed to determine appropriate reaction conditions. The microcrystalline compound is characterized by molecular simulation techniques, powder X‐ray diffraction, N2‐sorption, and TEM investigations.magnified image
Intermolecular Methoxycarbonylation of Terminal Alkynes Catalyzed by Palladium(II) Bis(oxazoline) Complexes
Authors: Kato Keisuke , Motodate Satoshi , Mochida Tomoyuki , Kobayashi Takuya , Akita Hiroyuki 
Published: February 2009

AbstractBoxing clever: Direct conversion of a terminal alkyne group into a β‐methoxyacrylate is realized with the aid of the bis(oxazoline) ligand (box). Acetyl and ketal protecting groups, free hydroxy groups, and acid‐sensitive glycosidic bonds are not affected under the reaction conditions. The one‐pot synthesis of (±)‐dihydrokawain from the homopropargyl alcohol is also achieved. tfa=trifluoroacetatemagnified image
Düsseldorfer Deckel – eine elegante Baugrubenaussteifung
Authors: Coßmann Rudolf , Hartmann‐Linden Ralf , Maurischat Udo , Veith Norbert 
Published: February 2009

AbstractEine Deckelbauweise für tiefe Baugruben mit einer Schlitzwandumschließung ist ein seit Jahrzehnten erprobtes Bauverfahren. Bei der Baugrube für das Bürohochhaus Sky Office in Düsseldorf mit 4 Untergeschossen wurde anstelle einer Rückverankerung mit Temporärankern eine Deckelbauweise ausgeführt, wobei die Gesamtfläche der Deckelöffnungen mehr als 50% der Deckenfläche betrug. Durch frühzeitige Einbindung aller am Bau Beteiligter und durch den bereits in der Planungsphase festgelegten Einsatz der Beobachtungsmethode während der Bauausführung konnte eine sichere und wirtschaftliche Bauweise realisiert werden (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Zu Verformungsverhalten und Rissgefährdung einer mineralischen Abdichtung im Deponiebau – infolge gekoppelter zyklischer hydraulischer und mechanischer Beanspruchung
Authors: Schanz Tom 
Published: February 2009

AbstractDas Verformungsverhalten einer mineralischen Abdichtung unter Umwelteinflüssen ist ein wichtiges Forschungsthema mit dem Schwerpunkt teilgesättigter Böden im Deponiebau. In Abhängigkeit von der kritische Saugspannung führen Setzungen zusammen mit Quellen und Schwinden des Bodens zu Rissen; andererseits können Initialrisse durch mechanische Kompression in solchen Bereichen geschlossen werden. In diesem Beitrag werden in Form von Feldmessungen die Auswirkungen von Schwellen und Schrumpfen auf eine verdichtete polymerverbesserte Bentonit‐Sand‐Mischung dargestellt. Zwei Methoden zur Beschreibung des Verformungsverhaltens von mineralischen Abdichtungen im Deponiebau unter gekoppelter hydraulisch‐mechanischer Beanspruchung werden vorgeschlagen, die exemplarisch auf das Testfeld einer mineralischen Abdichtung angewendet und verglichen werden (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Vascular engineering using human embryonic stem cells
Authors: Hanjaya‐Putra Donny , Gerecht Sharon 
Published: February 2009

AbstractEngineering vascularized tissue constructs remains a major problem in regenerative medicine. The formation of such a microvasculature—like the vasculogenesis in early embryogenesis that it closely resembles—is guided by biochemical and biophysical cues, such as growth factors, extracellular matrix proteins, hypoxia, and hydrodynamic shear. As they undergo spontaneous and directed vascular differentiation, human embryonic stem cells can be used as a model system to explore central issues in engineering vascularized tissue constructs and, potentially, to elucidate vasculogenic and angiogenic mechanisms involved in such vascular diseases as limb and cardiac ischemia. Because the conventional spontaneous differentiation approach can only isolate small quantities of vascular cells, recent efforts have sought to develop controlled approaches, including the development of three‐dimensional scaffolds to reengineer the microenvironments of early embryogenesis. This review focuses on emerging approaches to deriving and directing vasculatures from human embryonic stem cells and efforts to engineer 3D vasculatures from such derivatives. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009
Mass spectrometric analysis of innovator, counterfeit, and follow‐on recombinant human growth hormone
Authors: Jiang Haitao , Wu Shiaw‐Lin , Karger Barry L. , Hancock William S. 
Published: February 2009

AbstractWe have performed a detailed characterization of recombinant human growth hormone that included the identification of the entire sequence with disulfide linkages as well as subtle modifications by a sensitive liquid chromatography coupled online with tandem mass spectrometry (LC‐MS) approach using the accurate peptide mass (FTICR MS) and sequence assignment (MS/MS measurement). The extent of oxidation, deamidation, and chain cleavages were measured by the ratio of peak areas of the nonmodified peptide vs. the sum of peak area of the nonmodified and modified peptides in the same LC‐MS analysis. The subtle but distinct differences were found in the recombinant human growth from the three manufacturers (the follow‐on, counterfeit, and the original innovator products). In relative comparison, the follow‐on product had the highest degree of oxidation at methionine residues, followed by the counterfeit product, and the original innovator product had the least amount of oxidation at all three sites with the similar oxidation order. In cases, the oxidation order was Met14 > Met125 > Met170. In contrast, the follow‐on had the least amount of deamidation at aspargine (Asn149), and the counterfeit had the highest degree of deamidation at this site. For the chain cleavage, the follow‐on product had the highest cleavage occurring at T 10 peptide (between Asn99 and Ser100), the counterfeit had the highest cleavage on T4 peptide, (between Glu30 and Phe31), and the original innovator product with the least amount of cleavages on both sites. These subtle but distinct differences are likely because of nonidentical manufacturing, formulation procedures, and storage conditions. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009
Particle‐Based Synthesis of Peptide Arrays
Authors: Breitling Frank , Felgenhauer Thomas , Nesterov Alexander , Lindenstruth Volker , Stadler Volker , Bischoff F. Ralf 
Published: February 2009

AbstractHigh‐density peptide arrays with solid amino acid particles: Intermittent “freezing” of activated amino acid derivatives within solid particles allows a laser printer or a chip to spatially address these “postal packages”. Subsequent parallel coupling is started simply by melting a whole layer of 20 different amino acid particles, freeing the hitherto immobilized amino acids and resulting in the coupling of all 20 different amino acids to the support in a single coupling step.magnified imageLithographic methods allow for the combinatorial synthesis of >50 000 oligonucleotides per cm2, and this has revolutionized the field of genomics. High‐density peptide arrays promise to advance the field of proteomics in a similar way, but currently lag behind. This is mainly due to the monomer‐by‐monomer repeated consecutive coupling of 20 different amino acids associated with lithography, which adds up to an excessive number of coupling cycles. Combinatorial synthesis based on electrically charged solid amino acid particles resolves this problem. A color laser printer or a chip addresses the different charged particles consecutively to a solid support, where, when completed, the whole layer of solid amino acid particles is melted at once. This frees hitherto immobilized amino acids to couple all 20 different amino acids to the support in one single coupling reaction. The method should allow for the translation of entire genomes into sets of overlapping peptides to be used in proteome research.