bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’intelligence artificielle, une révolution dans le développement des médicaments
Authors: Moingeon Philippe , Garbay Christiane , Dahan Muriel , Fermont Irène , Benmakhlouf Ali , Gouyette Alain , Poitou Pierre , Saint-Pierre Alain ,   le Groupe de Veille IA et Sciences pharmaceutiques
Published: April 2024

L’intelligence artificielle (IA) et l’apprentissage automatique produisent des modèles prédictifs qui aident à la prise de décisions dans le processus de découverte de nouveaux médicaments. Cette modélisation par ordinateur permet de représenter l’hétérogénéité d’une maladie, d’identifier des cibles thérapeutiques, de concevoir et optimiser des candidats-médicaments et d’évaluer ces médicaments sur des patients virtuels, ou des jumeaux numériques. En facilitant à la fois une connaissance détaillée des caractéristiques des patients et en prédisant les propriétés de multiples médicaments possibles, l’IA permet l’émergence d’une médecine de précision « computationnelle » offrant des traitements parfaitement adaptés aux spécificités des patients.
Efficacy of Subthreshold Micropulse Laser for Central Serous Chorioretinopathy
Authors: Fasler Katrin , Turgut Ferhat , Gunzinger Jeanne Martine , Sommer Chiara , Muth Daniel Rudolf , Kinzl Stephan , Nilius Henning , Zweifel Sandrine , Somfai Gabor Mark 
Published: April 2024

Abstract
Purpose To evaluate the efficacy of a subthreshold micropulse laser (SML) in patients with central serous chorioretinopathy (CSCR).
Methods Retrospective clinical study conducted at the Departments of Ophthalmology at a university and a municipal hospital in Zurich, Switzerland. We enrolled acute and chronic CSCR patients with persistent subretinal fluid (SRF) treated with SML. Two treatment protocols (fluorescein/indocyanine green angiography or optical coherence tomography guided) were evaluated for efficacy after 3 and 6 months. The primary outcomes of the study were reduction and percentage of eyes with complete resolution of SRF 3 and 6 months after SML treatment. Secondary endpoints included changes in central subfield thickness (CST) and visual acuity (VA) after 3 and 6 months.
Results The study involved 37 eyes (35 patients, 48.6% chronic). A statistically significant reduction in SRF height and CST could be shown, irrespective of SRF duration, type of CSCR, or chosen guidance after 3 and 6 months: SRF − 40 µm (p < 0.01), CST − 52 µm (p < 0.01). Percentage of eyes with complete resolution of fluid at 3 and 6 months after SML were 24.3 and 21.6%, respectively. No statistically significant functional improvement (VA) could be shown. Multivariable regression and linear mixed regression analyses did not identify statistically significant differences in SRF reduction, CMT change, or VA improvement with respect to the type of CSCR or the treatment plan used (p > 0.05).
Conclusion The effectiveness of SML in CSCR is under continuous debate. Our study findings demonstrate structural but only little functional changes with SML. In view of the shortage of verteporfin for photodynamic therapy, SML remains an important therapeutic option for CSCR patients.
Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation
Authors: Zhang Pengyu , von Ungern-Sternberg Saskia , Hastenplug Luisa , Solari Fiorella A. , Sickmann Albert , Kuijpers Marijke J. E. , Heemskerk Johan W. M. , Walter Ulrich , Jurk Kerstin 
Published: April 2024

Background Platelet glycoprotein VI (GPVI) stimulation activates the tyrosine kinases Syk and Btk, and the effector proteins phospholipase Cγ 2 (PLCγ2) and protein kinase C (PKC). Here, the activation sequence, crosstalk, and downstream effects of this Syk-Btk-PKC signalosome in human platelets were analyzed.
Methods and Results Using immunoblotting, we quantified 14 regulated phospho-sites in platelets stimulated by convulxin with and without inhibition of Syk, Btk, or PKC. Convulxin induced fast, reversible tyrosine phosphorylation (pY) of Syk, Btk, LAT, and PLCγ2, followed by reversible serine/threonine phosphorylation (pS/T) of Syk, Btk, and downstream kinases MEK1/2, Erk1/2, p38, and Akt. Syk inhibition by PRT-060318 abolished all phosphorylations, except Syk pY352. Btk inhibition by acalabrutinib strongly decreased Btk pY223/pS180, Syk pS297, PLCγ2 pY759/Y1217, MEK1/2 pS217/221, Erk1/2 pT202/Y204, p38 pT180/Y182, and Akt pT308/S473. PKC inhibition by GF109203X abolished most pS/T phosphorylations except p38 pT180/Y182 and Akt pT308, but enhanced most Y-phosphorylations. Acalabrutinib, but not GF109203X, suppressed convulxin-induced intracellular Ca2+ mobilization, whereas all three protein kinase inhibitors abolished degranulation and αIIbβ3 integrin activation assessed by flow cytometry. Inhibition of autocrine ADP effects by AR-C669931 partly diminished convulxin-triggered degranulation.
Conclusion Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk, and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.
Contemporary Management of Pulmonary Embolism: Review of the Inferior Vena Cava ﬁlter and Other Endovascular Devices
Authors: Lei KaChon , DiCaro Michael V. , Tak Nadia , Turnbull Scott , Abdallah Ala , Cyrus Tillman , Tak Tahir 
Published: April 2024

AbstractInferior vena cava (IVC) filters and endovascular devices are used to mitigate the risk of pulmonary embolism in patients presenting with lower extremity venous thromboembolism in whom long-term anticoagulation is not a good option. However, the efficacy and beneﬁt of these devices remain uncertain, and controversies exist. This review focuses on the current use of IVC ﬁlters and other endovascular therapies in clinical practice. The indications, risks, and beneﬁts are discussed based on current data. Further research and randomized controlled trials are needed to characterize the patient population that would beneﬁt most from these interventional therapies.
Post-COVID-19 Rhino-Orbito-Maxillary Mucormycosis Defect: Our Surgical Experience with Single Stage Delayed Reconstruction Using Free Flap
Authors: Kala Prakash Chandra , Dixit Pawan Kumar , Katrolia Deepti , Karmakar Shilpi , Humnekar Akhilesh , Singla Priyanka , Singh Apoorva Pratap 
Published: April 2024

Abstract
Introduction The effect of the second wave of COVID-19 was immense in India, specifically in the form of vicious COVID-19-associated mucormycosis. A higher number of radical debridements are required for disease control in combination with antifungal drugs in cases of COVID-19-associated mucormycosis, which results in complex maxillofacial defects. We aimed to evaluate the clinical outcomes in patients with rhino-orbito-maxillary defects due to COVID-19-associated mucormycosis undergoing a single stage delayed free flap reconstruction.
Methodology This prospective, single-center, multisurgeon study was performed on eight patients with COVID-19-associated rhino-orbito-maxillary mucormycosis in the department of burns and plastic surgery. The postoperative clinical outcome was evaluated using the University of Washington Quality of Life Questionnaire for patient's quality of life (QOL), aesthetic numeric analog (ANA) scale for patient's satisfaction for aesthetics, and the functional intraoral Glasgow scale for speech and deglutition at 1 and 3 months.
Results The median age of the study patients was 40 years, with 75% of the patients being males. Diabetes mellitus (DM) was present in all the patients. Mucormycosis was diagnosed within the first 3 months of COVID-19 infection. Maxillary defect was present in 62.5% of patients, out of which 50% had bilateral maxillary defects. There was significant improvement in the QOL and the aesthetics of patients from 1 to 3 months (p < 0.001). Speech and deglutition were also improved at 3 months, but the difference was not statistically significant.
Conclusion Single stage delayed free flap reconstruction can be advocated in patients with COVID-19-associated rhino-orbito-maxillary mucormycosis defect as there is considerable improvement in patients' QOL, aesthetics, speech, and deglutition over a period of time.
Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1
Authors: Aquino Camila Henriques de , Moscovich Mariana , Marinho Murilo Martinez , Barcelos Lorena Broseghini , Felício André C. , Halverson Matthew , Hamani Clement , Ferraz Henrique Ballalai , Munhoz Renato Puppi 
Published: April 2024

AbstractDeep brain stimulation (DBS) is recognized as an established therapy for Parkinson's disease (PD) and other movement disorders in the light of the developments seen over the past three decades. Long-term efficacy is established for PD with documented improvement in the cardinal motor symptoms of PD and levodopa-induced complications, such as motor fluctuations and dyskinesias. Timing of patient selection is crucial to obtain optimal benefits from DBS therapy, before PD complications become irreversible. The objective of this first part review is to examine the fundamental concepts of DBS for PD in clinical practice, discussing the historical aspects, patient selection, potential effects of DBS on motor and non-motor symptoms, and the practical management of patients after surgery.
Trisomy 18: Prenatal Diagnosis and Outcome in a Tertiary Care Fetal Medicine Center in South India
Authors: Mahajan Rahul Ashok , Elayedatt Rinshi Abid , Malhotra Khushboo , Krishnan Vivek 
Published: April 2024

AbstractEdwards' syndrome (trisomy 18) is the second most common aneuploidy known in humans, with an overall incidence of 1 in 6,000 live births. It occurs due to the presence of complete or part of an extra copy of chromosome 18 in all or a few body cells of the affected fetus, and it causes major anomalies in the organ systems. Despite this, an accurate diagnosis is often not made antenatally due to its very varied phenotype and the subtle nature of some of the common and consistent findings associated with this condition. This leads to lapses or delays in cytogenetic confirmation as well as delays in decision regarding termination of pregnancies with this mostly lethal fetal aneuploidy. We describe the prenatal profile of 45 confirmed cases of trisomy 18 at a tertiary fetal medicine unit. The presence of a combination of ultrasound (US) findings described in these cases will help alert sonologists and clinicians to suspect this condition and offer a confirmative cytogenetic test without delay for prenatal diagnosis. This study describes the prenatal diagnostic profile of cytogenetically confirmed trisomy 18 cases in a tertiary fetal medicine center in India. A retrospective analysis of records of 45 prenatally diagnosed trisomy 18 cases at a single tertiary fetal medicine center over a period of 11 years was done. Data were collected to describe maternal demography, indication for evaluation, major and minor US findings (trimester-wise), type of invasive test, and gestational age at diagnosis. Outcomes in terms of pregnancy termination, miscarriage, stillbirth, or livebirth were documented. Presenting at a mean maternal age and gestation age of 31.7 years and 22 + 5 weeks, respectively, 41/45 (91%) fetuses showed major and 40/45 (89%) showed minor US findings with an overall US sensitivity of 100%. The most common major US finding was a cardiac anomaly in 26 (57.8%) patients, while clenched fist with pointing index finger, observed in 17 (37.8%) cases, was the most common minor US finding. Fetal growth restriction (FGR) was noted in 20 (44.4%) patients. After cytogenetic confirmation, 37.8% underwent termination, 17.8% had a fetal demise, and only 11.1% had live birth with the longest survival noted at 5.5 months postnatally. Gender was documented in 13 fetuses with a male-to-female ratio of 0.6. A meticulously performed US examination can detect a combination of anomalies that could alert the sonologist to the possibility of trisomy 18. While the US profile could vary among fetuses, an understanding of the spectrum of the anomalies commonly seen in these fetuses would enable caregivers to reach an early accurate diagnosis, and offer appropriate genetic counseling and pregnancy decisions in these cases.
Decomposing the comprehensive efficiency of major cities into divisions on governance, ICT and sustainability: network slack-based measure model
Authors: Wu Yue , Chang Dong-Shang 
Published: April 2024

AbstractThe rapid urbanization and population growth in major cities have given rise to enduring urban challenges, prompting local governments to assess urban development performance and customize urban planning strategies to meet these challenges. This study aims to formulate an evaluation framework for the comprehensive efficiency of major cities, centering on governance, Information and Communication Technology (ICT), and sustainability as fundamental aspects. Distinct from prior research, the framework employs the network slack-based measure (SBM) to unravel efficiency, concurrently scrutinizing input/output slack and link efficiency. Utilizing the network SBM model, the study assesses the comprehensive operational efficiencies of 38 major Chinese cities spanning from 2015 to 2019. The application of the Kruskal–Wallis test discerns differences in comprehensive efficiency between coastal and inland areas. The results indicate that governance, ICT, and sustainability significantly influence the comprehensive operations of cities. In addition to general and short-term policies, the implementation of the National New-Type Urbanization Plan by the Chinese central government has led to an increase in the number of cities demonstrating sustainable efficiency. Despite fluctuations in the efficiency gap during the study period, coastal cities consistently outperform their inland counterparts in terms of efficiency. Persistent geographical disparities underscore the imperative for balanced development. While acknowledging positive strides in sustainable urbanization, the study emphasizes the ongoing necessity to address the adverse impacts of urban development, positioning governance, ICT, and sustainability as indispensable elements in confronting the multifaceted challenges inherent in urban development. The research findings contribute significantly to the field of urban efficiency evaluation, accentuating the collaborative impact of governance, ICT, and sustainability.
Measurement setup for Nernst and Seebeck effect at high temperatures and magnetic fields tested on elemental bismuth and full-Heusler compounds
Authors: Parzer M. , Schmid T. , Garmroudi F. , Riss A. , Mori T. , Bauer E. 
Published: April 2024

In this work, a measurement setup to study the Seebeck and Nernst effect at high temperatures and high magnetic fields is introduced and discussed. The measurement system allows for simultaneous measurements of both thermoelectric effects up to 700 K and magnetic fields up to 12 T. Based on theoretical concepts, measurement equations are derived that counteract constant spurious offset voltages and, therefore, inhibit systematic errors in the measurement setup. The functionality is demonstrated on polycrystalline samples of elemental bismuth as well as various full-Heusler materials, exhibiting an anomalous Nernst effect. In all samples, the measured Seebeck and Nernst coefficients align excellently with the reported values. This allows future research to substantially extend the measured temperature and field intervals, commonly limited to temperatures below room temperature. For the first time, the thermoelectric and thermomagnetic properties of these materials are reported up to temperatures of 560 K.
Identities in conflict
Authors: Garcés-Conejos Blitvich Pilar , Bou Franch Patricia 
Published: April 2024

AbstractThis paper explores the construction of Latino identity in Spain. The term Hispanic (Latino later became the label of choice) was added to the US census in the 1970s, initially as an ethnic category, but it has undergone a process of racialization, making Latinos a distinct racial group in the US. The concept ofLatinidadhas been extensively studied in the US context. This paper adopts a netnographic approach to examine howLatinidadis constructed in Spain. To conduct this qualitative research, NVivo was used to analyze a reference corpus of over 5,000 online comments triggered by a video discussing the situation of Latinos in Spain that had been posted on YouTube byEl País. The study employs a multidisciplinary approach, drawing from fields like identity, impoliteness, and raciolinguistics. It particularly focuses on perceptions of visible minorities and attitudes towards language varieties different from European Spanish.
Cosmography with next-generation gravitational wave detectors
Authors: Chen Hsin-Yu , Ezquiaga Jose María , Gupta Ish 
Published: April 2024

AbstractAdvancements in cosmology through next-generation (XG) ground-based gravitational wave (GW) observatories will bring in a paradigm shift. We explore the pivotal role that GW standard sirens will play in inferring cosmological parameters with XG observatories, not only achieving exquisite precision but also opening up unprecedented redshifts. We examine the merits and the systematic biases involved in GW standard sirens utilizing binary black holes, binary neutron stars, and neutron star-black hole mergers. Further, we estimate the precision of bright sirens, golden dark sirens, and spectral sirens for these binary coalescences and compare the abilities of various XG observatories (A♯, cosmic explorer, Einstein telescope, and their possible networks). When combining different sirens, we find sub-percent precision over more than 10 billion years of cosmic evolution for the Hubble expansion rateH(z). This work presents a broad view of opportunities to precisely measure the cosmic expansion rate, decipher the elusive dark energy and dark matter, and potentially discover new physics in the uncharted Universe with XG GW detectors.
Energy spectrum and superfluidity breakdown of Bose–Einstein condensates in optical lattice under density-dependent artificial gauge field
Authors: Zhou Ming-Zhi , Ma Yun-E , Xu Shi-Dong , Mi Lai-Lai , Zhang Ai-Xia , Xue Ju-Kui 
Published: April 2024

Abstract
Nonlinear feedback between the gauge field and the material field can yield novel quantum phenomena. Here, the interplay between a density-dependent artificial gauge field and Bose–Einstein condensates (BECs) trapped in an optical lattice is studied. The energy spectrum and superfluidity represented by energetic and dynamical stabilities of the system are systematically discussed. A density-dependent artificial gauge field with a back-action between the BECs dynamics and the gauge field induces an effective atomic interaction that depends on the quasi-momentum and density of the condensates, resulting in a symmetry-broken energy spectrum and exotic stability phase diagram, that is, the system is only stable in a certain range of atoms density and under a limited lattice strength. The density-dependent artificial gauge field changes the sequence for the emergence of energetic and dynamical instability and the regimes of the energetic and dynamical instabilities are significantly separated, offering an efficient way to examine the energetic and dynamical instabilities of superfluids separately. In particular, the density-dependent artificial gauge field, as a mechanism for transferring momentum to the fluid, results in dynamic instability of the condensates even in free space. Our results provide deep insights into the dynamical response of superfluid systems to gauge fields and have potential applications for the coherent control of exotic superfluid states.
Gaussian-kernel weighted neighborhood preserving embedding algorithm and its application in fault detection
Authors: Wang Hancheng , Li Peng , Ai Mingxi , Wu Jiande , Yang Chuangyan , Pan Deen 
Published: April 2024

Abstract
Fault detection in industrial processes is essential for enhancing production safety. Despite the application of the neighborhood preserving embedding (NPE) algorithm in fault detection as a manifold learning technique, a notable limitation exists-NPE overlooks local geometric structure, leading to suboptimal fault detection and occasional false alarms. This paper introduces the Gaussian kernel weighted NPE (KW-NPE) algorithm to address this challenge. Specifically designed for precise weight assignment in local structures, KW-NPE strategically employs the Gaussian kernel method to project the spatial neighborhood set and capture comprehensive local structural characteristics. The weight assignment, dependent on feature values, enhances the retention of intrinsic structure during dimensionality reduction. A novel objective function further augments this process.To assess performance, a comprehensive composite index is introduced in a case study, amalgamating the false alarm rate and fault detection rate. The effectiveness of the KW-NPE algorithm is demonstrated through extensive simulations and its application to the Tennessee Eastman process dataset, highlighting its superiority over conventional approaches.
3D printed self-sensing cementitious composites using graphite and carbon microfibers
Authors: Liu Han , Laflamme Simon , D’Alessandro Antonella , Ubertini Filippo 
Published: April 2024

Abstract
Cementitious materials possessing self-sensing properties conferred through the incorporation of conductive fillers have attracted significant interest in the research community due to their potential application to structural health monitoring of civil infrastructure. A key advantage of cementitious sensors is that they can be organically embedded within cementitious structures to provide extremely robust monitoring capabilities. Of interest to this paper, the integration of cementitious sensors could be critical in empowering the 3D printing of cementitious composites by enabling real-time monitoring of additive manufacturing. Such integration could be achieved by 3D printing self-sensing cementitious nodes during the fabrication process. 3D printed self-sensing cementitious sensors could also be topologically engineered to achieve new opportunities in sensing of existing and new concrete and other cementitious structures. This paper presents one of the earliest studies, if not the first, on the 3D printing of self-sensing functionalized composites. The self-sensing cementitious composite sensors are fabricated using a cementitious matrix doped with graphite (G) and carbon microfibers. Various mixtures are studied, in particular G-only, G with milled carbon microfibers (MCMF), G with chopped carbon microfibers (CCMF), and G with MCMF and CCMF. A study of the percolation curves reveals that it is possible to attain electrical percolation using these conductive particles to create strain-sensitive sensors by leveraging the boosted piezoresistive effect. A study of strain sensing performance conducted on various specimens fabricated using different mixture types reveals the optimal concentration of dopants under different types of conductive particles. It is found that the optimal mixture that yields optimal performance also improves the Young’s Modulus of the specimens by 42.2% compared to cement-only specimens. Overall, this optimal mixture composed of 10% weight-to-cement G (10 wt% G), 0.250 wt% MCMF, and 0.125 wt% CCMF yielded a static gauge factor of 622, a resolution of 167

μ
ε

, an accuracy of 19.24

μ
ε

, and a Young’s Modulus of 798 MPa.