bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Shape of History
Authors: Masny Michal 
Published: February 2025

Abstract
Some philosophers believe in improvement: they think that the world is a better place than it used to be, and that future generations will fare even better. Others see decline: they claim that the condition of humanity has deteriorated and will continue to do so. Much ink has also been spilt over what explains these historical patterns. These two disagreements about the shape of history concern largely descriptive issues. But there is also a third, purely normative question that has been neglected: is it better if a history features a pattern of improvement rather than deterioration, holding other things equal? This paper develops an answer to this normative question and explores some of its implications for matters related to the future of humanity.
Neo-Latin: Literature
Authors: Maes Isabelle , Maleux Maxime , Smets Simon , Van Rooy Raf , Marsico Clementina , Luggin Johanna , Schaffenrath Florian , Šubarić Lav 
Published: February 2025

Abstract
This is a critical bibliographical survey of academic studies published in 2023 in the area of Neo-Latin Studies.
The Long Transition Towards Socialism and the End of Capitalism, written by Torkil Lauesen
Authors: Stoiljkovic Ivan 
Published: February 2025

Abstract
Torkil Lauesen’s analysis and practice is rooted in the understanding of imperialism as a major factor in the development of capitalism. It foregrounds the experience of the Global South and takes seriously revolutionary movements that won state power outside of the imperial core. The Long Transition Towards Socialism and the End of Capitalism is openly activist writing with an eye to the practical that has for far too long been missing from western academia.
The Socialist Transitional State and the Contradictions of the Multipolar World-system
Authors: Lauesen Torkil 
Published: February 2025

Abstract
The article analyses the role of the socialist transitional state in the emerging multipolar world-system. In the first section, I present the concept of the socialist transitional state. Using the analytic tool of the principal contradiction I describe the transformation from the bipolar world-system, into the unipolar world-system during neoliberal globalization, and finally into the into multipolarity. With the concept of the transitional state and multipolarity in place, I discuss how they interact in the world-system. First their position vis-à-vis a declining U.S. hegemony. Then I examine the contradictions within the multipolar world-system. Finally, I draw some strategic conclusions from this analysis, which can be useful in the future struggle to end capitalism and build socialism.
الأمثال الشَّحْرِيَّة: ذاكرة الثقافة الشفوية في ظفار، عُمان
Authors: الشحري محمد مستهيل 
Published: February 2025

ملخص البحث
‫يمكن القول بأن الأمثال الشحرية تشكّل جزءًا أساسيًا من الذاكرة الثقافية التواصلية ومن الخزان الثقافي الخاص في هذه الديار عبر التاريخ والتي تعكس بلا شك علاقة الإنسان بالأرض واستمراريته في أرض ظفار. يتناول البحث عددًا من الأمثال المنطوقة التي تعبر عن ثقافة مجتمعية تعتمد على الذاكرة في التواصل واكتساب المعرفة وتداول الثقافة. تكشف الأمثال عن المصادر الأولية في الثقافة الشعبية ومدى ارتباطها بالمعتقد الديني أو العرف الاجتماعي. وتتناول جزءا من ثقافة المجتمع تجاه المرأة فتقدر المرأة وتثمن دورها الاجتماعي، وتوضح الأمثال الشحرية عن نمط اقتصادي رعوي يشارك فيه الرجال والنساء معًا.‬
A Minaic Dedicatory Inscription by the Wife of King Waqahʾīl Ṣādiq
Authors: Al-Said Said 
Published: February 2025

Abstract
This study examines a newly discovered Minaic inscription that documents for the first time the wife of the Minaean king, Waqahʾīl Ṣādiq, offering sacrifices to the Minaean deity Wadd and dedicating both herself and her possessions to his protection. The research aims to analyze the inscription in terms of its structure and meaning while also exploring the implications of its vocabulary by comparing it to other ancient South Arabian inscriptions and Semitic languages. In addition, the study attempts to date the inscription to the reign of King Waqahʾīl Ṣādiq, probably around the 3rd century BCE.
Violence and nicotine replacement therapy in a high dependency mental health unit
Authors: Spiers Alistair , Chin Chew Sok , Ng Kyle YuWei , Taran Michael , Thornton Phoebe , Theodoros Theo , Coleman Mat 
Published: February 2025

Introduction Nicotine withdrawal is associated with aggression on mental health wards. This study examined whether the introduction of an inhaled form of Nicotine Replacement Therapy (NRT) improved acceptability and reduced observed aggression on a high dependency mental health unit (HDU), at a tertiary level metropolitan hospital. Method This retrospective cohort study included tobacco smokers admitted to the HDU over two consecutive years, following a smoking ban at the hospital. Transdermal patch and gum forms of NRT were available in the first year, with an inhaled form introduced the following year. Aggression was quantified using the Brøset violence checklist. Statistical analysis included the chi-squared test of independence and student’s t-test. Results Of the 89 people admitted, 85% smoked tobacco. Of these, 71% had a history of violence and 33% had been incarcerated for this. NRT use increased from 26% to 33% in the second year. Use of NRT was associated with a significant reduction in aggression across the study period, and the overall aggression was lower in the second year. Conclusion Greater choice of NRT agents can lead to improved use and acceptance, associated with reduced inpatient aggression. Acceptance, dosing and administration of NRT can all be improved by assertive policy.
The risks of exposure to surgical smoke in operating room staff: A cross-sectional observational study
Authors: Gjini Enkeleda , Terzoni Stefano , Carelli Lara , Lodini Roberta , Ferrara Filippo , Rosato Mattia , Ricci Cristian , Santoro Giusy , Ferrara Paolo 
Published: February 2025

Background Electromedical equipment, widely used in surgical procedures, generates a gaseous byproduct called surgical smoke (SS) that is potentially harmful to healthcare personnel in the operating theater. Surgical smoke evacuation devices have proven effective in limiting staff exposure but are not always adequately used in the operating room. The potential risks of such exposure could be better explored in the literature, and in-depth studies are lacking in the Italian setting. Objective To study individual health impact and knowledge by operating room staff regarding exposure to surgical smoke during professional activity. Methods Cross-sectional observational study on a convenience sample. All healthcare personnel working within the operating compartment of a public hospital in Lombardy, Northern Italy, were invited to answer a survey questionnaire created according to literature evidence. Results 101 healthcare professionals responded; 91.1% reported one or more symptoms attributable to SS exposure. Surgical face masks were the most frequent devices against SS (75.2%). 44.6% of the sample did not know what devices are recommended against SS exposure. Conclusions Improving the healthcare professionals’ knowledge of the danger related to SS is crucial to protecting their health in the surgical compartment.
Which Prognostic Models Best Predict Clinical Disease Progression, Worsening, and Activity in People with Multiple Sclerosis? A Cochrane Review Summary with Commentary
Authors: Amatya Bhasker , Khan Fary 
Published: February 2025

Background Prognostic models have the potential to support people with Multiple Sclerosis (pwMS) and clinicians in treatment decision-making, enable stratified and precise interpretation of interventional trials, and offer insights into disease mechanisms. Despite many researchers being involved in developing these models to predict clinical outcomes in multiple sclerosis (MS), no widely accepted prognostic model is currently used in clinical practice. Objective Commentary on the review by Reeve et al. (2023) to identify and summarise multivariable prognostic models, and their validation studies for quantifying the risk of clinical disease progression, worsening, and activity in pwMS. Methods This review included studies evaluating statistically developed multivariable prognostic models aiming to predict clinical disease progression, worsening, and activity, as measured by disability, relapse, conversion to definite MS, conversion to progressive MS, or a composite of these in adult individuals with MS. Results The review included 57 studies, comprising 75 model developments, 15 external validations, and six author-reported validations. Only two models were validated multiple times externally, and none by independent researchers. The outcomes evaluated included disease progression (41%), relapses (8%), conversion to definite MS (18%), and conversion to progressive MS (28%). All models required specialist skills, 59% needed specialized equipment, and 52% lacked sufficient details for application or independent validation. Reporting quality was poor, and most models had a high risk of bias. The findings suggest increases in the number of participants on treatment, diverse diagnostic criteria, the use of biomarkers, and machine learning over time. Conclusions Despite the development of many prognostic prediction models in pwMS, current evidence is insufficient to recommend any of these models for clinical use due to the high risk of bias, poor reporting, and lack of independent validation. The review's findings necessitate a cautious approach to integrating existing MS prognostic models into rehabilitation practice.
A framework to standardize gait study protocols in Parkinson's disease
Authors: Mancini Martina , Hausdorff Jeffrey M , Pelosin Elisa , Bonato Paolo , Camicioli Richard , Ellis Terry D , Klucken Jochen , Gifford Larry , Fasano Alfonso , Nieuwboer Alice , Kopil Catherine , Klapper Katharina , Kirsch Leslie , Dexter David T , Fuest Rosie , Miller Vicki , Asis Angelica , Müller Martijn LTM , Stephenson Diane , Mirelman Anat 
Published: February 2025

Background Research over the past twenty years has shown that gait outcomes have a high sensitivity for diagnosing Parkinson's disease (PD), for detecting the effects of interventions, and for monitoring disease progression, even in early disease. However, the lack of standardization in protocols and reported gait measures is impeding data aggregation across study sites and contributes to heterogeneity in the results, thus limiting the adoption of gait outcomes in clinical trials. Objective To provide recommendations for a minimum set of gait measures to be adopted in projects evaluating people with PD to enhance standardization across the field. Methods The Gait Advisors Leading Outcomes for Parkinson's (GALOP) committee is an advisory committee for the MJFF. Based on a five-step approach, GALOP generated recommendations for standardizing protocols that assess quantitative gait measures, following expert consensus on best practices. Results Built on the literature and consensus amongst experts, we recommend a minimum set of meta-data to accompany gait protocols and a minimum gait assessment protocol to be performed at a comfortable speed. Suggestions on challenging testing are provided. Conclusions To support and empower the scientific community, we have generated recommendations to collect and share gait data gathered from people with PD using an open data repository. Standardizing gait protocols and outcomes in PD has the potential of accelerating research and clinical trials, harmonizing protocols across study sites, fostering collaborations, and in the long run, improving patient care and quality of life.
Structuring and centralizing breast cancer real-world biomarker data from pathology reports through C-LAB® artificial intelligence platform
Authors: Le Borgne Florent , Garnier Camille , Morisseau Camille , Navarrete Yanis , Echeverria Yanina , Mir Juan , Calafell Jaume , Perennec Tanguy , Kerdraon Olivier , Frenel Jean-Sébastien , Raimbourg Judith , Campone Mario , Paz Maria Fe , Bocquet François 
Published: February 2025

Purpose To evaluate the effectiveness of C-LAB®, an artificial intelligence (AI) platform, in extracting, structuring, and centralizing biomarker data from breast cancer pathology reports within the challenging, heterogeneous dataset of the Institut de Cancérologie de l’Ouest (ICO). Methods C-LAB® was deployed at the ICO to analyze HER2 and hormonal receptor data from breast cancer pathology reports. During the development phase, 292 anatomic pathology reports were used to design and refine the rule-based extraction algorithm through an iterative process of monitoring and adjustments. After finalizing the algorithm, it was applied to a total of 2323 anatomic pathology reports. To evaluate the platform's accuracy, performance metrics could only be calculated for a subset of these reports that were also available in the structured National Epidemiological Strategy and Medical Economics (ESME) database. Out of the 2323 pathology reports belonging to 487 patients analyzed by C-LAB®, 666 corresponded to 97 patients present in the ESME database. These reports were used as the gold standard for performance assessment, as ESME provides structured data against which the outputs of the C-LAB® algorithm could be compared. Results C-LAB® achieved over 80% agreement with human extractions (precision, recall, and F1-score) in structuring biomarker data from complex, unstructured pathology reports, despite dataset variability and optical character recognition errors. While the ESME database served as a benchmark, its reliance on single manual data entry without secondary review introduces potential inaccuracies, suggesting the observed performance reflects close alignment between human and algorithmic extractions rather than absolute accuracy. C-LAB® demonstrates significant potential to reduce manual workload, centralize data, and enable scalable, real-time reporting. Conclusion AI technologies like C-LAB® show significant potential in creating accessible and actionable digital factories from complex pathology data, aiding in the precision management of diseases such as breast cancer diagnostics and treatment.
Radiomics analysis based on plain X-rays to detect spinal fractures with posterior wall injury
Authors: Liu Wangmi , Zhang Xiaxuan , Tang Ruofu , Yu Chengcheng , Sun Guofang 
Published: February 2025

Purpose Spinal fractures, particularly those involving posterior wall injury, pose a heightened risk of instability and significantly influence treatment strategies. This study aimed to improve early diagnosis and treatment planning for spinal fractures through radiomics analysis based on plain X-ray imaging. Methods This retrospective study analyzed plain X-rays of patients with spinal fractures at the thoracolumbar junction. Radiomic features were extracted from both anteroposterior and lateral plain spine radiographs to evaluate the utility of radiomics in detecting posterior wall injury. Diagnostic accuracy, sensitivity, and specificity of the radiomics models were assessed and compared with the performance of a spine surgeon. Results A total of 100 patients were included in the study, and four radiomic features were identified to construct radiomic signatures. In the training set, the RandomForest, ExtraTrees, and eXtreme Gradient Boosting (XGBoost) models achieved an area under the curve (AUC) of 1. In the validation set, the highest AUC value was 0.889, achieved by the RandomForest and XGBoost models. The diagnostic accuracy, sensitivity, and specificity of the radiomics models outperformed those of the spine surgeon. Conclusions Radiomics analysis based on plain X-ray imaging demonstrates significant potential for detecting posterior wall injury following spinal fractures. This approach offers a promising tool for early diagnosis and informed clinical decision-making in the management of spinal fractures.
Self-medication with NSAIDs and purchase of branded and over-the-counter medicines: Analysis of a national survey in Peru
Authors: Benites-Meza Jerry K , Pinedo-Castillo Liseth , Cabanillas-Lazo Miguel , Boyd-Gamarra María A , Herrera-Añazco Percy , Mougenot Benoit , Benites-Zapata Vicente A 
Published: February 2025

Background: This study aimed to determine the association between self-medications with nonsteroidal anti-inflammatory drugs (NSAIDs) and the purchase of branded and over-the-counter medications in Peru. Design and methods: This secondary analysis used a representative survey of Peru from 2014 to 2016. The exposure variable was self-medication with NSAIDs, defined as “the purchase of NSAIDs for oneself without a prescription.” The outcome was the purchase of branded and over-the-counter medications. Crude prevalence ratios (cPR) and adjusted prevalence ratios (aPR) with their respective 95% confidence intervals (95% CI) were calculated. Results: Of the total of 2158 participants, 52.80% were women with an average age of 40.24 years. The prevalence of self-medication with NSAIDs was 68.21%, whereas the rates of purchasing branded and over-the-counter medications were 63.78% and 13.16%, respectively. The adjusted Poisson regression analysis showed an association between self-medication with NSAIDs and the purchase of branded (aPR = 1.18; 95% CI: 1.12–1.25; p < 0.001) and over-the-counter (aPR = 2.38; 95% CI: 1.95−2.90; p < 0.001) medications. Conclusions: Approximately 7/10 users who self-medicate with NSAIDs chose branded medications, whereas nearly 1/5 opt for over-the-counter medications. Self-medication with NSAIDs was associated with a higher likelihood of purchasing branded and over-the-counter medications.
Implementation of the virtual transitional care stroke intervention for older adults with stroke and multimorbidity: A qualitative descriptive study
Authors: Markle-Reid Maureen , Fisher Kathryn , Walker Kimberly M. , Cameron Jill I. , Dayler David , Fleck Rebecca , Gafni Amiram , Ganann Rebecca , Hajas Ken , Koetsier Barbara , Mahony Robert , Pollard Chris , Prescott Jim , Rooke Tammy , Whitmore Carly 
Published: February 2025

Background Older adults with stroke and multimorbidity experience frequent care transitions, which are often poorly coordinated and fragmented. We conducted a pragmatic randomized controlled trial (RCT) to test the implementation and effectiveness of the Transitional Care Stroke Intervention (TCSI), a 6-month, multi-component, evidence-informed intervention to support older adults with stroke and multimorbidity using outpatient stroke rehabilitation services. The TCSI was designed to support self-management, improve health outcomes, and enhance the quality and experience of care transitions. Objective To explore the facilitators and challenges to implementing the TCSI, from the perspective of healthcare providers (HCPs) (n = 12) and Managers (n = 3). Methods Data collection and analysis were guided by the Consolidated Framework for Implementation Research (CFIR). Data were collected from study documents, individual and group interviews conducted with HCPs and a Care Coordinator, and surveys from managers. Data were analyzed using thematic analysis. Results Intervention implementation was facilitated by: a) strong collaborative and interdependent HCP team relationships, b) dedicated resources (funding, staffing) to support intervention delivery, c) training and ongoing support, customized to individual HCP needs, d) organizational readiness, strong leadership, and effective champions, e) structures to facilitate virtual information-sharing, and f) regular monitoring of intervention implementation. Implementation challenges included: a) COVID-19 related challenges (staff turnover, community service disruptions), b) poor communication with community service providers, c) documentation burden (intervention-related), and d) virtual care delivery. Conclusions This research enhances understanding of the diversity of factors influencing implementation of the TCSI, and the conditions under which implementation is more likely to succeed.
Healthcare professionals’ attitudes towards social prescribing in specialist children’s weight management services
Authors: Garside Megan , Homer Catherine , Dayson Christopher , Dowrick Lorna , Pickering Katie , Wright Neil 
Published: February 2025

Abstract

Background
Addressing increasing rates of childhood obesity is a global priority. High numbers of children and young people are living with obesity and experience significant physical and mental health impacts. Social prescribing research has shown it can help improve young people’s physical and mental health, meaning it may be a helpful way to provide additional, personalised support to young people who are living with obesity, and to help to address the health inequalities experienced by this group. This study aimed to provide an overview of the current understanding and use of social prescribing from healthcare professionals working in specialist weight management services in England, and to identify perceived benefits and barriers to future implementation of social prescribing in these services.

Methods
A national survey was distributed online between April and July 2023 to healthcare professionals working within specialist weight management clinics across England to gather information regarding their current use and understanding of social prescribing.

Results
Thirty-eight completed surveys were analysed, with good representation from services across England. Staff felt they had an understanding of what social prescribing is and were willing to use it. Anticipated benefits included improvements to wellbeing and providing opportunities for physical activity and family support. Reported barriers included limited capacity from staff and a need for more training around how to identify appropriate community-based services to link with.

Conclusion
Healthcare professionals working in children’s weight management services felt social prescribing could be beneficial for the families they worked with. However, to support implementation in their services, there is a need for further resource, such as staff time and training, to help develop relationships between clinical services and community-based services.
Renal disorders in Autoimmune Polyendocrinopathy Candidiasis Ectodermal dystrophy (APECED): a systematic review
Authors: Shafiei Mohammadreza , Hosseini Solale , Ghadimi Soodeh , Mirzaee Mahbubeh , Keikhah Mohammadamin , Ardalan Nastaran , Mohkam Masoumeh , Tamiji Mehrdad , Jamee Mahnaz 
Published: February 2025

Abstract

Background
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyendocrine syndrome type I (APS-I) is an inborn error of immunity (IEI) with an immune dysregulation phenotype, mainly characterized by endocrine and non-endocrine manifestations including adrenal insufficiency, chronic mucocutaneous candidiasis, and ectodermal dystrophy. Renal disorders seem to be a significant morbidity in APECED patients, requiring further investigations.

Methods
The literature search was conducted in PubMed, Web of Science, and Scopus databases using relevant keywords, and included articles were systematically reviewed regarding the clinical and immunological features. APECED patients with at least one nephrological complication were included.

Results
Ninety-three APECED patients from 30 studies were identified. More than half of the patients (38,52%) presented nephrocalcinosis. The second and third most prevalent renal complications were tubulointerstitial nephritis (TIN) (23,31%), and hypertension (13,18%), respectively. Other less frequent renal disorders including renal tubular acidosis (RTA) glomerulonephritis were also reported among patients. Additionally urinary tract infections (UTI), were also common among cases (15,20.5%).

Conclusions
Renal complications in APECED represent a significant issue that should be monitored and considered in managing these patients to preserve renal function and improve patients’ outcomes.