bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide
Authors: van der Heijden Joost W. , Oerlemans Ruud , Tak Paul P. , Assaraf Yehuda G. , Kraan Maarten C. , Scheffer George L. , van der Laken Conny J. , Lems Willem F. , Scheper Rik J. , Dijkmans Ben A. C. , Jansen Gerrit 
Published: February 2009

AbstractObjectiveTo determine whether multidrug‐resistance efflux transporters are expressed on immune effector cells in synovial tissue from patients with rheumatoid arthritis (RA) and compromise the efficacy of methotrexate (MTX) and leflunomide (LEF).MethodsSynovial tissue biopsy samples obtained from RA patients before treatment and 4 months after starting treatment with MTX (n = 17) or LEF (n = 13) were examined by immunohistochemical staining and digital image analysis for the expression of the drug efflux transporters P‐glycoprotein, multidrug resistance–associated protein 1 (MRP‐1) through MRP‐5, MRP‐8, MRP‐9, and breast cancer resistance protein (BCRP), and the relationship to clinical efficacy of MTX and LEF was assessed.ResultsBCRP expression was observed in all RA synovial biopsy samples, both pretreatment and posttreatment, but not in control noninflammatory synovial tissue samples from orthopedic patients. BCRP expression was found both in the intimal lining layer and on macrophages and endothelial cells in the synovial sublining. Total numbers of macrophages in RA patients decreased upon treatment; in biopsy samples with persistently high macrophage counts, 2‐fold higher BCRP expression was observed. Furthermore, median BCRP expression was significantly increased (3‐fold) in nonresponders to disease‐modifying antirheumatic drugs (DMARDs) compared with responders to DMARDs (P = 0.048). Low expression of MRP‐1 was found on synovial macrophages, along with moderate expression in T cell areas of synovial biopsy specimens from one‐third of the RA patients.ConclusionThese findings show that the drug resistance–related proteins BCRP and MRP‐1 are expressed on inflammatory cells in RA synovial tissue. Since MTX is a substrate for both BCRP and MRP‐1, and LEF is a high‐affinity substrate for BCRP, these transporters may contribute to reduced therapeutic efficacy of these DMARDs.
A quality indicator set for systemic lupus erythematosus
Authors: Yazdany Jinoos , Panopalis Pantelis , Gillis Joann Zell , Schmajuk Gabriela , MacLean Catherine H. , Wofsy David , Yelin Edward ,   Systemic Lupus Erythematosus Quality Indicators Project Expert Panels
Published: February 2009

AbstractObjectiveTo systematically develop a quality indicator (QI) set for systemic lupus erythematosus (SLE).MethodsWe used a validated process that combined available scientific evidence and expert consensus to develop a QI set for SLE. We extracted 20 candidate indicators from a systematic literature review of clinical practice guidelines pertaining to SLE. An advisory panel revised and augmented these candidate indicators and, through 2 rounds of voting, arrived at 25 QIs. These QIs advanced to the next phase of the project, in which we employed a modification of the RAND/UCLA Appropriateness Method. A systematic review of the literature was performed for each QI, linking the proposed process of care to potential improved health outcomes. After reviewing this scientific evidence, a second interdisciplinary expert panel convened to discuss the evidence and provide final ratings on the validity and feasibility of each QI.ResultsThe final expert panel rated 20 QIs as both valid and feasible. Areas covered included diagnosis, general preventive strategies (e.g., vaccinations, sun avoidance counseling, and screening for cardiovascular disease), osteoporosis prevention and treatment, drug toxicity monitoring, renal disease, and reproductive health.ConclusionWe employed a rigorous multistep approach with systematic literature reviews and 2 expert panels to develop QIs for SLE. This new set of indicators provides an opportunity to assess health care quality in patients with SLE and represents an initial step toward the important goal of improving care in this patient population.
Rheumatoid arthritis, its treatments, and the risk of tuberculosis in Quebec, Canada
Authors: Brassard Paul , Lowe Anne‐Marie , Bernatsky Sasha , Kezouh Abbas , Suissa Samy 
Published: February 2009

AbstractObjectiveTo determine the risk of tuberculosis (TB) among a cohort of patients with rheumatoid arthritis (RA) in Quebec and assess whether this risk is associated with exposure to nonbiologic disease‐modifying antirheumatic drugs (DMARDs).MethodsWe studied a cohort of patients with RA identified from the Quebec provincial physician billing and hospitalization databases for 1980–2003. TB incidence rates were determined for the period 1992–2003 and compared with the general population, standardized for age and sex using the standardized incidence ratio (SIR). Conditional logistic regression was used in a nested case–control analysis to estimate the rate ratio (RR) of TB related to nonbiologic DMARD exposure during the year before the index date.ResultsOf the 24,282 patients with RA in the cohort, 50 cases of TB were identified. The standardized incidence rate was 45.8 cases per 100,000 person‐years compared with 4.2 cases per 100,000 person‐years in the general population of Quebec (SIR 10.9, 95% confidence interval [95% CI] 7.9–15.0). The adjusted RR of TB was 2.4 (95% CI 1.1–5.4) with corticosteroid use and 3.0 (95% CI 1.6–5.8) with nonbiologic DMARD use.ConclusionThe age‐ and sex‐standardized incidence rate of TB in RA patients is 10 times that of the general population. At least some of this risk may be related to nonbiologic DMARD and corticosteroid therapies. Our data support the role of TB screening before initiation of any immunosuppressive therapy.
Bacterial Glycoprofiling by Using Random Sequence Peptide Microarrays
Authors: Morales Betanzos Carlos , Gonzalez‐Moa Maria J. , Boltz Kathryn W. , Vander Werf Brian D. , Johnston Stephen Albert , Svarovsky Sergei A. 
Published: February 2009

AbstractMicrobial fingerprints: We screened bacterial lipopolysaccharides (LPS) on random sequence peptide microarrays (see scheme); the results revealed distinct binding patterns for different bacteria. Most of the LPS binding sequences, which resemble natural antimicrobial peptides showed growth inhibition activity. This technology paves the way for systematic investigation of disease‐associated changes in poorly defined complex glycobiomolecules.magnified imageCurrent analytical methods have been slow in addressing the growing need for glyco‐analysis. A new generation of more empirical high‐throughput (HTP) tools is needed to aid the advance of this important field. To this end, we have developed a new HTP screening platform for identification of surface‐immobilized peptides that specifically bind O‐antigenic glycans of bacterial lipopolysaccharides (LPS). This method involves screening of random sequence peptide libraries in addressable high‐density microarray format with the newly developed luminescent LPS–quantum dot micelles. Screening of LPS fractions from O111:B4 and O55:B5 serotypes of E. coli on a microarray consisting of 10 000 20‐mer peptide features revealed minor differences, while comparison of LPS from E. coli O111:B4 and P. aeruginosa produced sets of highly specific peptides. Peptides strongly binding to the E. coli LPS were highly enriched in aromatic and cationic amino acids, and most of these inhibited growth of E. coli. Flow cytometry and isothermal titration calorimetry (ITC) experiments showed that some of these peptides bind LPS in‐solution with a Kd of 1.75 μM. Peptide selections against P. aeruginosa were largely composed of hydrogen‐bond forming amino acids in accordance with dramatic compositional differences in O‐antigenic glycans in E. coli and P. aeruginosa. While the main value of this approach lies in the ability to rapidly differentiate bacterial and possibly other complex glycans, the peptides discovered here can potentially be used off‐array as antiendotoxic and antimicrobial lead compounds, and on‐array/on‐bead as diagnostic and affinity reagents.
How to Build Molecules with Large Magnetic Anisotropy
Authors: Cirera Jordi , Ruiz Eliseo , Alvarez Santiago , Neese Frank , Kortus Jens 
Published: February 2009

AbstractPredicting single‐molecule magnets? Magnetic anisotropy, a property that plays a key role in single‐molecule magnets (SMMs), has been analyzed by using theoretical methods. Mononuclear complexes and the dependence of the magnetic anisotropy on their geometrical and electronic structure, as well as how such mononuclear complexes must be combined as building blocks to obtain polynuclear complexes with large anisotropy (see figure) are considered.magnified imageThe magnetic anisotropy of mononuclear transition‐metal complexes has been studied by means of electronic structure calculations based on density functional theory. The variation of the zero‐field splitting (ZFS) parameters has been analyzed for the following characteristic distortions: a tetragonal Jahn–Teller distortion, the Bailar twist, the Berry pseudorotation, and the planarization of tetrahedral complexes. Finally, the coupling of mononuclear building blocks in polynuclear complexes to obtain a large negative magnetic anisotropy necessary to improve their single‐molecule‐magnet (SMM) behavior has been studied.
Chemical and Structural Properties of Carbonaceous Products Obtained by Hydrothermal Carbonization of Saccharides
Authors: Sevilla Marta , Fuertes Antonio B. 
Published: February 2009

AbstractCarbon‐rich‐quick scheme: A carbon‐rich solid product made up of uniform micrometer‐sized spheres of tunable diameter has been synthesized by the hydrothermal carbonization of saccharides. These microspheres possess a core–shell chemical structure based on the different nature of the oxygen functionalities between the core and the outer layer (see figure).magnified imageA carbon‐rich solid product, here denoted as hydrochar, has been synthesized by the hydrothermal carbonization of three different saccharides (glucose, sucrose, and starch) at temperatures ranging from 170 to 240 °C. This material is made up of uniform spherical micrometer‐sized particles that have a diameter in the 0.4–6 μm range, which can be modulated by modifying the synthesis conditions (i.e., the concentration of the aqueous saccharide solution, the temperature of the hydrothermal treatment, the reaction time, and type of saccharide). The formation of the carbon‐rich solid through the hydrothermal carbonization of saccharides is the consequence of dehydration, condensation, or polymerization and aromatization reactions. The microspheres thus obtained possess, from a chemical point of view, a core–shell structure consisting of a highly aromatic nucleus (hydrophobic) and a hydrophilic shell containing a high concentration of reactive oxygen functional groups (i.e., hydroxyl/phenolic, carbonyl, or carboxylic).
Enhanced Pd‐Catalyzed Hydrogenation of Olefins within Polymeric Microreactors under Organic/Aqueous Biphasic Conditions
Authors: Lan Yang , Zhang Minchao , Zhang Wangqing , Yang Li 
Published: February 2009

AbstractA microreactor of hollow polymeric microspheres with Pd nanoparticles immobilized in its wall is designed for hydrogenation of olefins under organic/aqueous biphasic catalysis. The microreactor has an ability to encapsulate and concentrate olefins within the vacancy of the hollow microspheres in the aqueous phase, and therefore hydrogenation within the microreactors runs efficiently with concentrated reactants under organic/aqueous biphasic condition (see scheme).magnified image
Highly Enantioselective Organocatalytic Addition of Aldehydes to N‐(Phenylmethylene)benzamides: Asymmetric Synthesis of the Paclitaxel Side Chain and Its Analogues
Authors: Dziedzic Pawel , Schyman Patric , Kullberg Martin , Córdova Armando 
Published: February 2009

AbstractEasily side‐tracked: A simple route to the paclitaxel side chain and its analogues is based on the (R)‐proline‐catalyzed addition of aldehydes to N‐(phenylmethylene)benzamides, followed by oxidation of the resulting protected α‐hydroxy‐β‐benzoylaminoaldehydes (92–99 % ee). Esterification of the subsequent phenylisoserine derivatives with baccatin III gives paclitaxel analogues (see scheme).magnified imageA simple highly enantioselective organocatalytic addition of aldehydes to N‐(phenylmethylene)benzamides is presented. The application of (R)‐proline as the catalyst and subsequent oxidation of the protected α‐hydroxy‐β‐benzoylaminoaldehydes (92–99 % ee) gives access to esterification‐ready phenylisoserine derivatives such as the protected paclitaxel (taxol) side chain. Esterification of these derivatives with baccatin III gives access to the cancer chemotherapeutic substance paclitaxel and its analogues that do not exist in nature.
ChemInform Abstract: Structural Stability and Elastic and Electronic Properties of Rhenium Borides: First Principle Investigations.
Authors: Gou Huiyang , Wang Zhibin , Zhang Jingwu , Yan Shuting , Gao Faming 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Conversion of Layered Ruddlesden—Popper‐Related Structure Y2O3‐Doped Sr2CeO4 into Fast Oxide Ion‐Conducting Fluorite‐Type Y2O3‐Doped CeO3.
Authors: Gerlach Ryan Georg , Bhella Surinderjit Singh , Thangadurai Venkataraman 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure and Electrical Resistivity of NdCo2Al8.
Authors: He Wei , Zhong Haichang , Liu Hongrui , Zhang Jiliang , Zeng Lingmin 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sintering, Chemical Stability and Electrical Conductivity of the Perovskite Proton Conductors BaCe0.45Zr0.45M0.1O3‐ δ (M: In, Y, Gd, Sm).
Authors: Lv Jingde , Wang Ling , Lei Dai , Guo Hongxia , Kumar R. V. 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Frustration and Spin Disorder in Isostructural M(μ‐OH2)2[Au(CN)2]2 (M: Mn, Fe, Co) Coordination Polymers Containing Double Aqua‐Bridged Chains: SQUID and μSR Studies.
Authors: Lefebvre Julie , Tyagi Pooja , Trudel Simon , Pacradouni Vighen , Kaiser Christina , Sonier Jeff E. , Leznoff Daniel B. 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magneto Transport Characterization of the Sn‐Doped TbMnO3 Manganites.
Authors: Pekala M. , Drozd V. , Fagnard J. F. , Vanderbemden Ph. , Ausloos M. 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Structure of Er6Ni2Sn.
Authors: Prokes K. , Sechovsky V. , Syshchenko O. 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of CuII and NiII Substituted Polytungstates and Molybdates.
Authors: Dey K. C. , Sharma V. 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure and Magnetism of [n‐BuNH3]12 [Cu4(GeW9O34)2] ×14H2O Sandwiching a Rhomblike Cu48+ Tetragon Through α‐Keggin Linkage.
Authors: Yamase Toshihiro , Abe Hiroko , Ishikawa Eri , Nojiri Hiroyuki , Ohshima Yuhgo 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Characterization and Crystal Structure of a Novel Os(II)‐Supported Tungstoarsenate [HAsW7O28Os(dmso)3]6‐.
Authors: Bi Li‐Hua , Li Bao , Wu Li‐Xin , Shao Kui‐Zhan , Su Zhong‐Min 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nd2K2IrO7 and Sm2K2IrO7: Iridium(VI) Oxides Prepared under Ambient Pressure.
Authors: Mugavero Samuel J. III , Smith Mark D. , Yoon Won‐Sub , zur Loye Hans‐Conrad 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cycloaddition of Alkynyl Ketones with N‐Tosylimines Catalyzed by Bu3P and DMAP: Synthesis of Highly Functionalized Pyrrolidines and Azetidines.
Authors: Meng Ling‐Guo , Cai Peijie , Guo Qingxiang , Xue Song 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Encapsulated Molecular Catalysts in Polysiloxane Gels: Ruthenium Cluster‐Catalyzed Isomerization of Alkenes.
Authors: Motoyama Yukihiro , Abe Motonori , Kamo Kazuyuki , Kosako Yusuke , Nagashima Hideo 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Nonsymmetric Pincer‐Catalyzed Suzuki—Miyaura Arylation of Benzyl Halides and Other Nonactivated Unusual Coupling Partners.
Authors: Ines Blanca , Moreno Isabel , SanMartin Raul , Dominguez Esther 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Methods for Chemoselective O‐tert‐Butoxycarbonylation of Phenols and Their Regeneration from the O‐t‐Boc Derivatives.
Authors: Chankeshwara Sunay V. , Chebolu Rajesh , Chakraborti Asit K. 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient One‐Pot Synthesis of β‐Amino/β‐Acetamido Carbonyl Compounds via ZrCl4‐Catalyzed Mannich‐Type Reaction.
Authors: Sanjeeva Reddy Cherkupally , Purnachandra Reddy Gurrala 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Elimination of β‐Thioalkoxy Alcohols under Mitsunobu Conditions. A New Synthesis of Conjugated Enynes from Propargylic Dithioacetals.
Authors: Chen Chih‐Wei , Luh Tien‐Yau 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: L‐Selectride‐Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules.
Authors: Ghosh Arun K. , Kass Jorden , Anderson David D. , Xu Xiaoming , Marian Christine 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New One‐Pot, Four‐Component Synthesis of 1,2‐Amino Alcohols: TiCl3/t‐BuOOH‐Mediated Radical Hydroxymethylation of Imines.
Authors: Clerici Angelo , Ghilardi Alessandra , Pastori Nadia , Punta Carlo , Porta Ombretta 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amino‐Sugar Modular Ligands—Useful Cores for the Formation of Asymmetric Copper 1,4‐Addition Catalysts.
Authors: De Roma Antonella , Ruffo Francesco , Woodward Simon 
Published: February 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.