bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in the rat submandibular gland is influenced by pre- and post-natal high-fat diet exposure
Authors: Sangsuriyothai Pornchanok , Watari Ippei , Serirukchutarungsee Saranya , Satrawaha Sirichom , Podyma-Inoue Katarzyna Anna , Ono Takashi 
Published: March 2024

Background: Incretins, i.e., glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) promote insulin secretion to reduce postprandial blood sugar. Previous studies found incretins in the salivary glands. However, the role of GLP-1 and GIP in the submandibular gland (SMG) is unclear. This study investigates the effects of a high-fat diet (HFD) on the expression of GLP-1 and GIP throughout the development of rat SMG.Methods: Pregnant 11-week-old Wistar rats were divided into two groups: those fed on a standard diet (n = 5) and those fed on a HFD (n = 5). From day 7 of pregnancy and throughout the lactation period, all the rats were fed on either a chow diet or HFD. The newborns were divided into four subgroups (n = 6): standard diet males (SM), HFD males (HM), standard diet females (SF), and HFD females (HF). The SMGs of 3- and 10-week-old rats from each subgroup were collected under general anesthesia. Moreover, body weight, food intake, and fasting blood sugar were measured. The mRNA expression of GLP-1 and GIP was quantified, and the localization was observed using immunohistochemistry (p &lt; 0.05).Results: GLP-1 mRNA expression was statistically significantly more upregulated in HM than in HF at 3 weeks. Moreover, GLP-1 mRNA expression was significantly higher in HM than in both SM and HF at 10 weeks. Although a decreasing trend was observed in GIP mRNA expression in both 3- and 10-week-old rats fed on a HFD, a significant difference between HM and SM only occurred at 3 weeks. Furthermore, the GIP mRNA expression of HM was lower than that of HF at 10 weeks. Immunohistochemical staining revealed GLP-1 and GIP expression mainly in the SMG duct system. Moreover, vacuolated cytoplasm in the duct was observed in rats fed on a HFD.Conclusion: Exposure to HFD during pre- and post-natal periods increased GLP-1 mRNA expression in the SMGs of male rats. However, GIP expression decreased following the HFD in male newborns. Furthermore, a decreasing trend of GIP mRNA expression was observed in male newborns after HFD feeding. Sex influenced incretin hormones secretion and obesity-related conditions. HFD during pre- and post-natal periods reprograms the epigenome, contributing to subsequent disease development.
Aerobic capacity and mitochondrial function in bipolar disorder: a longitudinal study during acute phases and after clinical remission
Authors: Giménez-Palomo Anna , Guitart-Mampel Mariona , Roqué Gemma , Sánchez Ester , Borràs Roger , Meseguer Ana , García-García Francesc Josep , Tobías Esther , Valls-Roca Laura , Anmella Gerard , Valentí Marc , Olivier Luis , de Juan Oscar , Ochandiano Iñaki , Andreu Helena , Radua Joaquim , Verdolini Norma , Berk Michael , Vieta Eduard , Garrabou Glòria , Roca Josep , Alsina-Restoy Xavier , Pacchiarotti Isabella 
Published: March 2024

BackgroundAerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. We aimed to assess longitudinally intra-individual differences in these factors during mood episodes and remission in BD.MethodsThis study included eight BD patients admitted to an acute psychiatric unit. Incremental cardiopulmonary exercise test (CPET) was conducted during acute episodes (T0), followed by constant work rate cycle ergometry (CWRCE) to evaluate endurance time, oxygen uptake at peak exercise (VO2peak) and at the anaerobic threshold. The second test was repeated during remission (T1). Mitochondrial respiration rates were assessed at T0 and T1 in peripheral blood mononuclear cells.ResultsEndurance time, VO2peak, and anaerobic threshold oxygen consumption showed no significant variations between T0 and T1. Basal oxygen consumption at T1 tended to inversely correlate with maximal mitochondrial respiratory capacity (r=-0.690, p=0.058), and VO2peak during exercise at T1 inversely correlated with basal and minimum mitochondrial respiration (r=-0.810, p=0.015; r=-0.786, p=0.021, respectively).ConclusionsOur preliminary data showed that lower basal oxygen consumption may be linked to greater mitochondrial respiratory capacity, and maximum oxygen uptake during the exercise task was associated with lower basal mitochondrial respiration, suggesting that lower oxygen requirements could be associated with greater mitochondrial capacity. These findings should be replicated in larger samples stratified for manic and depressive states.
Work stress and changes in heart rate variability among employees after first acute coronary syndrome: a hospital-based longitudinal cohort study
Authors: Hu Zhao , Cao Xingyu , Jing Pan , Zhang Bangying , Shi Yunke , Siegrist Johannes , Li Jian , Zhang Min 
Published: March 2024

BackgroundWork stress is considered as a risk factor for coronary heart disease, but its link with heart rate variability (HRV) among heart attack survivors is unknown yet. The aim of this study was to investigate associations between baseline work stress and the changes of HRV over one-year after onset of acute coronary syndrome (ACS).MethodsHundred and twenty-two patients with regular paid work before their first ACS episode were recruited into this hospital-based longitudinal cohort study. During hospitalization (baseline), all patients underwent assessments of work stress by job strain (JS) and effort-reward imbalance (ERI) models, and were assigned into low or high groups; simultaneously, sociodemographic and clinical data, as well depression, anxiety, and job burnout, were collected. Patients were followed up 1, 6, and 12 months after discharge, with HRV measurements at baseline and each follow-up point. Generalized estimating equations were used to analyze the effects of baseline work stress on HRV over the following 1 year.ResultsAfter adjusting for baseline characteristics and clinical data, anxiety, depression, and burnout scores, high JS was not associated with any HRV measures during follow-up (all p &gt; 0.10), whereas high ERI was significantly related to slower recovery of 5 frequency domain HRV measures (TP, HF, LF, VLF, and ULF) (all p &lt; 0.001), and marginally associated with one time domain measure (SDNN) (p = 0.069). When mutually adjusting for both work stress models, results of ERI remained nearly unchanged.ConclusionWork stress in terms of ERI predicted lower HRV during the one-year period after ACS, especially frequency domain measures.
How does the problem-oriented innovation system (PIS) help in the management of cardiovascular diseases?
Authors: Nasri Shohreh , Amani Javad , Safavi Gelayol , Ghazinoory Sepehr 
Published: March 2024

IntroductionCardiovascular diseases are a multifaceted and complex problem in the health system that can change the priorities of the economic, social, and even political systems of countries. Therefore, as a grand challenge (GC), its management requires adopting a systematic, interdisciplinary, and innovative approach. In Iran, the most common causes of death, have changed from infectious and diarrheal diseases to cardiovascular diseases since 1960.MethodsIn this study, the novel framework of the problem-oriented innovation system (PIS) has been used, and cardiovascular diseases in Iran have been selected as a case study. To this end, first, the main challenges related to cardiovascular diseases in Iran were identified in two layers of “governance-centered” (including legal and policy gaps, insufficient education, financing, lack and unbalanced distribution of medical personnel) and “society driven” (including unhealthy diet and lifestyle, uncontrolled and hard-to-regulate factors, and high costs) through a library research. Then, the functional-structural framework of the problem-oriented innovation system was used to analyze cardiovascular diseases and provide policy recommendations.ResultsThe findings indicate that based on the eight functions of the problem-oriented innovation system, an important part of cardiovascular diseases can be managed and controlled in three short-term, medium-term, and long-term periods.ConclusionIncreasing public awareness in the form of university courses, participation of the government with the private sector in building and equipping specialized cardiovascular centers, creating an electronic health record from birth, implementing a family health plan focusing on less developed areas, supporting agriculture and guaranteeing the purchase of agricultural products and healthy food, increasing the capacity of accepting students in medical and paramedical fields, and allocating pharmaceutical currency in the form of pharmaceutical subsidies directly to cardiovascular patients, are among the most important policy recommendations for this grand challenge.
Evaluation of salivary tumor necrosis factor α as a diagnostic biomarker in oral submucosal fibrosis and squamous cell carcinoma of the oral cavity and oropharynx: a cross sectional observational study
Authors: Abdul Aziz Shaikh Sabiha , Denny E Ceena , Kumarchandra Reshma , Natarajan Srikant , Sunny Johan , Shenoy Nandita , K. P Nandita 
Published: March 2024

IntroductionTumor necrosis factorα(TNF-α) is known to be associated with chronic inflammation, and its expression has been shown to increase in advanced cancers. Chronic inflammation is a characteristic feature of oral submucous fibrosis (OSMF), which is a potentially malignant disorder (PMD). Squamous cell carcinoma (SCC) is associated with considerable mortality and morbidity and an early detection or monitoring would greatly help in achieving an effective cure. TNF-α was thus evaluated for use as a biomarker in the present study according to the stage of OSMF and histological grade of SCC in the oral cavity and oropharynx.MethodsThis study included 45 patients divided into 3 groups—OSMF group, SCC group and control group—each comprising 15 participants. Saliva samples were collected from each patient, and salivary TNF-α levels were estimated using an ELISA kit.ResultsStatistical analysis revealed no significant differences in TNF-α levels among the OSMF, SCC and control groups; however, there was an increase in the salivary TNF-α level in patients with stage 3 disease according to the clinical stage of OSMF, for which thepvalue was 0.027.DiscussionAn increase in the TNF-α concentration with increasing clinical stage suggested a role for TNF-α in the spread of OSMF involvement in anatomical structures of the oral cavity and oropharynx. No significant difference in salivary TNF-α levels was noted among the OSMF, SCC and control groups.ConclusionThe study showed a positive correlation of TNF-α with increasing stages of OSMF but was not a reliable biomarker in the categorization of the same.
What motivates bridge building across pernicious group divides? The effects of regulatory motives, framing, and fit on increasing constructive engagement across political and racial divisions
Authors: Coleman Peter T. , Phan Lan H. 
Published: March 2024

IntroductionToday, the U.S. and countless other democracies have found themselves dangerously divided across political and racial-ethnic differences. Under these conditions, more extreme actors often wield disproportionate influence, with moderate citizens tending to disengage politically, sparking a vicious cycle.MethodsSix studies (N = 2,179) were conducted to investigate ways to mobilize citizens to engage in bridge-building activities fostering intergroup tolerance and compassion. Derived from basic regulatory theories of motivation, we tested the effects of stronger prevention (mitigating negative outcomes) vs. promotion (seeking ideal outcomes) and assessment (evaluating the best way to proceed) vs. locomotion (just “getting it done”) motivational orientations and the fit vs. non-fit framing effects of how the activities were presented on differences in engagement with political and racial bridge-building activities across political, racial, and gender groups in the U.S. We hypothesized that individuals with stronger levels of each of the four motivational mindsets would be more likely to express willingness to engage in bridging activities when they were framed in ways consistent (fitting) vs. inconsistent (non-fitting) with their more chronic orientations.Results and discussionFindings supported our hypotheses with some qualifiers and revealed important political, racial, and gender group differences on motivation and bridge-building for different types of engagement activities.
Systematic Review of Longitudinal Evidence and Methodologies for Research on Neighborhood Characteristics and Brain Health
Authors: Michael Yvonne L. , Senerat Araliya M. , Buxbaum Channa , Ezeanyagu Ugonwa , Hughes Timothy M. , Hayden Kathleen M. , Langmuir Julia , Besser Lilah M. , Sánchez Brisa , Hirsch Jana A. 
Published: March 2024

Objective: Synthesize longitudinal research evaluating neighborhood environments and cognition to identify methodological approaches, findings, and gaps.Methods: Included studies evaluated associations between neighborhood and cognition longitudinally among adults &gt;45 years (or mean age of 65 years) living in developed nations. We extracted data on sample characteristics, exposures, outcomes, methods, overall findings, and assessment of disparities.Results: Forty studies met our inclusion criteria. Most (65%) measured exposure only once and a majority focused on green space and/or blue space (water), neighborhood socioeconomic status, and recreation/physical activity facilities. Similarly, over half studied incident impairment, cognitive function or decline (70%), with one examining MRI (2.5%) or Alzheimer’s disease (7.5%). While most studies used repeated measures analysis to evaluate changes in the brain health outcome (51%), many studies did not account for any type of correlation within neighborhoods (35%). Less than half evaluated effect modification by race/ethnicity, socioeconomic status, and/or sex/gender. Evidence was mixed and dependent on exposure or outcome assessed.Conclusion: Although longitudinal research evaluating neighborhood and cognitive decline has expanded, gaps remain in types of exposures, outcomes, analytic approaches, and sample diversity.
EFEKTIVITAS EDUKASI GIZI MENGGUNAKAN MEDIA FLASHCARD DAN POWERPOINT TERHADAP PENGETAHUAN, SIKAP DAN PERILAKU GIZI SEIMBANG PADA SISWA SEKOLAH DASAR
Authors: Tsania Nanda , Rahmat Mamat , Priawantiputri Witri , Fauziyah Roro Nur 
Published: March 2024

Background: Balanced nutrition is a daily food composition that contains nutrients both types and amounts according to body needs. Balanced nutrition is needed to student for their growth period. Most of elementary school student do not know about balanced nutrition because they are still focused on the concept of “4 sehat 5 sempurna” where they think that eating rice should be more than side dishes and vegetables, even some said that drinking milk alone is enough and does not need other food. Purpose: This research aims to determine the effectiveness of providing nutrition education using flashcard and powerpoint media on increasing knowledge, attitudes and behavior of balanced nutrition in students of SDN Pasirkaliki Mandiri 2 Cimahi. Method: The research design used was a quasi-experimental with pre-test and post-test control group. The sample using purposive sampling with 62 samples. Statistical analysis using Paired T-Test, Wilcoxon and T-Independent. Results: The results shows that there is an increase in knowledge about balanced nutrition in the intervention group (p=0.000) and the control group (p=0.000), attitudes in the intervention group (p=0.014) and the control group (p=0.004), behavior in the intervention group (p=0.004) and there was no increase in behavior regarding balanced nutrition in the control group (p=0.398). Conclusion: There is no difference in the average increase in knowledge, attitudes and behavior of balanced nutrition between flashcard educational media and powerpoint media. Recommendation: Flashcard educational media needs to be redeveloped both from the appearance and from the choice of language used to attract students so as to get better results.
Key words: Nutrition Education, Flashcard, Powerpoint, Balanced Nutrition
HUBUNGAN POLA ASUH DOMINAN ORANG TUA DENGAN KEJADIAN TEMPER TANTRUM PADA USIA BALITA
Authors: Angelin Jibrilian , Cahyaningsih Henny , Sofyana Haris , Kusmiati Sri , Nursyamsiyah Nursyamsiyah , Ariyanti Metia Ariyanti 
Published: March 2024

ABSTRAK
Orang tua banyak menemui permasalahan dalam proses tumbuh kembang anak seiring dengan semakin kompleksnya keterampilan yang harus dipelajari anak serta bertambahnya usia anak. Salah satunya adalah perilaku temper tantrum atau sering disebut tantrum. Anak-anak usia 2-5 tahun meluapkan frustasinya dengan mengamuk, jika hal tersebut berlangsung terlalu sering maka dikatakan tidak normal. Pentingnya pola asuh orang tua dalam menghadapi masalah yang terjadi pada anak karena ikatan kebersamaan dan ikatan emosional yang dapat mengidentifikasi diri mereka sebagai anggota keluarga. Penelitian ini bertujuan untuk mengetahui hubungan pola asuh dominan orang tua dengan kejadian temper tantrum pada usia balita. Penelitian ini menggunakan jenis penelitian studi korelasi.Teknik sampling yang digunakan adalah total sampling dengan jumlah responden sebanyak 48 anak usia 1-5 tahun. Instrumen yang digunakan adalah Kuisioner Pola Asuh Orang Tua dan Kuesioner Temper Tantrum. Hasil uji analisis chi square dengan tingkat kesalahan (Alpha) 0,05 diperoleh hasil yang signifikan (p=0,015). Maka disimpulkan Ho ditolak sehingga adanya hubungan pola asuh dominan orang tua dengan kejadian temper tantrum pada usia balita. Bagi setiap orang tua diharapkan dapat memberikan pola asuh yang baik yaitu pola asuh yang diberikan sesuai dengan tempat, kondisi, dan masalahnya sehingga tidak menimbulkan kebingungan dan stres bagi anak.
Kata Kunci : Pola asuh orang tua, perilaku temper tantrum

ABSTRACT
Many parents encounter problems in the process of growth and development of children along with the increasingly complex skills that must be learned by children and increasing age of the child. One of them is temper tantrum behavior or often called tantrum. Children aged 2-5 years express their frustration by throwing a tantrum, if it goes on too often it is said to be abnormal. The importance of parenting parents in dealing with problems that occur in children because of the bond of togetherness and emotional ties that can identify themselves as family members. This study aims to determine the relationship of dominant parenting with the incidence of temper tantrums at the age of five. This study uses a correlation study. The sampling technique used is total sampling with 48 respondents aged 1-5 years. The instruments used were the Parenting Parenting Questionnaire and the Temper Tantrum Questionnaire. Chi square analysis test results with an error rate (Alpha) of 0.05 obtained significant results (p = 0.015). So it was concluded that Ho was rejected so there was a relationship between the dominant parenting style with the incidence of temper tantrums at the age of five. For every parent, it is expected to be able to provide good parenting, namely parenting provided according to the place, condition, and the problem so that it does not cause confusion and stress for the child.
Keywords: Parenting method, temper tantrum behavior
Hubungan Self Care dengan Kualltas Hidup pada Pasien Congestlve Heart Fallure (CHF)
Authors: Santika Chiara Sukma , Rohyadi Yosep , Setiawan Asep , Fathudin Yogasliana 
Published: March 2024

Prevalensi penyakit gagal jantung di Indonesia berdasarkan diagnosis dokter sebesar 1,5% atau sekitar 1.017.290 penduduk. Kematian terbanyak yang sebelumnya disebabkan oleh penyakit infeksi kini beralih ke penyakit kardiovaskular dan degeneratif yang diprediksi menjadi 5 kali lebih banyak penyebab kematian dibandingkan dengan penyakit infeksi. Tujuan penelitian ini adalah untuk mengetahui hubungan self care dengan kualitas hidup pada pasien CHF. Gagal jantung merupakan keadaan darurat medis akibat dari jumlah darah yang dipompa jantung manusia dalam setiap menit (cardiac output) tidak dapat memenuhi kebutuhan metabolisme normal tubuh, hal ini menyebabkan penurunan fungsional tubuh yang memengaruhi tindakan perlakuan pasien terhadap self care dalam kehidupan nya, perlakuan self care yang buruk menyebabkan penurunan kualitas hidup yang mana merupakan tingkatan yang menggambarkan keunggulan hidup seseorang individu. Desain penelitian menggunakan descriptive correlational. Teknik pengumpulan sampel menggunakan purposive sampling, Sehingga sampel didapatkan 90 responden. Alat ukur menggunakan kuisioner Minnesota living with heart failure dan Self care heart failure index. Dilakukan Analisa data metode Chi Square. Diperoleh hasil penelitian , adanya hubungan antara self care dengan kualitas hidup dengan nilai p value 0.00. Perlunya perilaku self care yang baik dalam upaya peningkatan kualitas hidup penting bagi pasien CHF dan perlunya pengembangan skill bagi tenaga kesehatan khususnya perawat mengenai Pendidikan Kesehatan kepada penderita CHF dalam penerapan self care yang baik dalam kehidupan sehari – hari.
PENGARUH BREASTCARE TERHADAP PEMBENGKAKAN PAYUDARA PADA IBU NIFAS DI UPT PUSKESMAS CIPAMOKOLAN
Authors: Faridah Fitri , Widaningsih Neneng 
Published: March 2024

Salah satu masalah yang sering muncul pada masa nifas adalah pembengkakan payudara. Pembengkakan payudara erat kaitannya dengan penundaan menyusui, pengosongan payudara yang tidak efektif dan posisi menyusui yang tidak tepat pada ibu menyusui. Hal ini dapat berisiko terhadap pemberian susu formula akibat payudara terasa nyeri dan tidak nyaman sehingga cakupan ASI Eksklusif tidak memenuhi target cakupan. Strategi non farmakologis yang dapat dilakukan untuk mengatasi masalah yaitu breast care menggunakan minyak zaitun. Breast care atau perawatan payudara merupakan upaya untuk mencegah, mengurangi, dan mengatasi pembengkakan payudara. Kandungan minyak zaitun dapat merelaksasikan otot payudara. Tujuan dari laporan ini untuk mengetahui pengaruh breastcare terhadap pembengkakan payudara pada ibu nifas. Metode penelusuran artikel dengan menggunakan data based Google Scholar, Pubmeed dan Cochrane Library sesuai dengan kriteria inklusi dan eksklusi. Sedangkan, metode intervensi dilakukan 2 kali sehari (pagi dan sore) dengan durasi 10-15 menit selama 7 hari menggunakan minyak zaitun. Hasil laporan dari penilaian pembengkakan payudara menggunakan Six Point Engorgement Scale (SPES) sebelum dan sesudah intervensi menunjukkan perbedaan yang signifikan dengan penurunan 4 skala. Dapat disimpulkan bahwa breast care dengan menggunakan minyak zaitun berpengaruh terhadap pembengkakan payudara pada ibu nifas.
EVIDENCE-BASED CASE REPORT (EBCR) PENCEGAHAN HYPOTERMI MENGGUNAKAN PLASTIK
Authors: Ekawati Ina , Nur Hadianti Dian 
Published: March 2024

Angka Kematian pada bayi baru lahir khususnya pada BBLR salah satunya disebabkan karena hipotermia. Penanganan hipotermia pada BBLR banyak metode yang dilakukan, diantaranya: metode inkubator, metode kanguru dan metode kantong plastik. Tujuan penelitian ini adalah ingin mengetahui pengaruh penggunaan plastik pada BBL dengan BBLR dalam mencegah hypotermi. metode penetiliah adalah telaah jurnal dengan penelusuran artikel dengan menggunakan data based Pubmeed dan Cochrane Library. Hasil Penelitian pada kasus ini penggunaan plastik untuk menghangatkan bayi sangatlah berpengaruh. Dimana BBL dengan BBLR pada saat itu suhunya 360C dan setelah di bungkus plastik, kurang lebih 15 menit kemudian suhu naik menjadi normal 36,90C. Sejalan dengan hasil penelitiian dari Valizadeh,Leila dkk bahwa Hasil penelitian menunjukkan bahwa penggunaan penutup plastik efektif dalam mengatur suhu tubuh bayi prematur usia kehamilan 28-30 minggu dan berat lahir 800-1250 gr yang dirawat di NICU pada hari ke-2 dan ke-3 rawat inap.