bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring the Long-Term Effectiveness of Miltefosine in Indian Post-Kala-Azar Dermal Leishmaniasis
Authors: Roy Sutopa , Moulik Srija , Roy Madhurima , Ghosh Manab K. , Chaudhuri Surya Jyati , Pandey Dhruv K. , Jain Saurabh , Dagne Daniel Argaw , Chatterjee Mitali 
Published: March 2024

ABSTRACT.
Post-kala-azar dermal leishmaniasis (PKDL), the dermal sequel to visceral leishmaniasis (VL), is characterized by hypopigmented macules (macular) and/or papules and nodules (polymorphic). Post-kala-azar dermal leishmaniasis plays a significant role in disease transmission, emphasizing the need for monitoring chemotherapeutic effectiveness. Accordingly, this study aimed to quantify the parasite burden in PKDL patients after treatment with miltefosine by a quantitative polymerase chain reaction (qPCR). A Leishmania kinetoplastid gene-targeted qPCR was undertaken using DNA from skin biopsy specimens of patients with PKDL at three time points, i.e., at disease presentation (week 0, n = 157, group 1), upon completion of treatment (week 12, n = 39, group 2), and at any time point 6 months after completion of treatment (week ≥36, n = 54, group 3). A cycle threshold (Ct) <30 was considered the cutoff for positivity, and load was quantified as the number of parasites/µg genomic DNA (gDNA); cure was considered when samples had a Ct >30. The parasite load at disease presentation (group 1) was 10,769 (1,339–80,441)/µg gDNA (median [interquartile range]). In groups 2 and 3, qPCR results were negative in 35/39 cases (89.7%) and 48/54 cases (88.8%), respectively. In the 10/93 (10.8%) qPCR-positive cases, the parasite burdens in groups 2 and 3 were 2,420 (1,205–5,661)/µg gDNA and 22,195 (5,524–100,106)/µg gDNA, respectively. Serial monitoring was undertaken in 45 randomly selected cases that had completed treatment; all cases in groups 2 or 3 had a Ct >30, indicating cure. Overall, qPCR confirmed an 89.2% cure (as 83/93 cases showed parasite clearance), and the persistent qPCR positivity was attributed to nonadherence to treatment or unresponsiveness to miltefosine and remains to be investigated.
Bacteriological Study of Proteus mirabilis Isolated from Different Clinical Samples
Authors: Albujassim Ameer S. , Al-khateeb Sumaya NajimAbedali , Alsherees Hashim , Rasool Inam abid Aljabar , Al-Nafakh Rana Talib , Yasir Saif jabbar , Alasady Raad Abdulameer , Hamza Al-Kraity Wijdan Rajh 
Published: March 2024

Abstract: This study focuses on isolating and identifying 17 strains of Proteus mirabilis from a total of 135 clinical samples obtained from patients who visited Hila Teaching Hospital between October 2014 and February 2015. The isolates collected from patients diagnosed with urinary tract infections accounted for 11 cases or 64.7% of the total. In contrast, patients with ear infections contributed 3 cases, making up 17.6% of the total. In addition, the isolates acquired from patients with diarrhea, wound, and vaginal infection each accounted for 1 (5.9%) of the total cases. The collected isolates have been cultivated on specialized media and identified using biochemical reactions.
Some virulence factors of all isolates are studied, and the results showed that all bacterial isolates 17(100%) produced hemolysin, urease, Bacteriocin (proticin), and swarming, while 16(94.1%) of isolate produced beta-lactamase. Antibiogram of P. mirabilis isolates has been studied and it has been found that all isolates were entirely resistant to Imipenem 17(100%), while most of the P. mirabilis isolates were sensitive to Ertapenem so the resistant only 3(17.6%). Furthermore, the resistance of isolates to Amoxicillin and Cefotaxime 14(82.3%), also 9(52.9%) of them were resistant to Amoxiclave, 11(64.7%) of them were resistant to Ceftriaxone and 4(23.5%) of them were resistant to Cefepime Clavulanic acid.
The Application of Brainstorming Method in Developing Ideas in The Production of Television Documentary Side of Life Episode Not The Same
Authors: Eko Wahyuanto  , Edi Giantoro  , Joehananto Djoko Teguh Widodo  , Risnaeni Yuniar  
Published: March 2024

The Side Of Life Television Documentary Program episode Not The Same is a program that presents information about the issue of sexual harassment to men by women. Male victims of sexual harassment are often not believed and even made into a joke by society. This documentary program presents information through the victim as a resource person in providing a chronology of events and feelings of victims who are not trusted by family and society. The creation of this television documentary program production work aims to produce a television documentary program by maximizing the role of the producer in developing ideas by using the brainstorming method which aims to make the production run well and have clear and abundant information so that it can be understood by the audience. The writer as a producer focuses on how the producer's creativity in developing ideas using the brainstorming method in television documentaries so that they can present information and knowledge. A television documentary program begins with some footage. Insert footage is used as the opening of the program followed by the program title and program episode. The Side Of Life program contains three sequences, each of which contains important and interesting information. Through the brainstorming method, it produces a program that is informative and becomes a medium for public education.
Pengaruh Tingkat Sosial Ekonomi dan Gender Terhadap Pemilihan Transportasi Untuk Perjalanan Kerja di Kota Manado
Authors: Tanor Lauri Sharen Debra , Waani Joice Elfrida , Rompis Semuel Yacob Recky 
Published: March 2024

Penelitian ini bertujuan untuk menganalisis pengaruh tingkat sosial ekonomi dan gender terhadap pemilihan moda transportasi untuk perjalanan kerja di Kota Manado. Penelitian ini menggunakan pendekatan kuantitatif dengan menyebarkan kuisioner kepada 400 responden, dan teknik analisis menggunakan Structural Equation Modeling (SEM) dengan menggunakan software SmartPLS 3. Data yang diperoleh dari kuisioner kemudian diinput kedalam SmartPLS 3, yang kemudian akan diolah datanya sehingga menghasilkan hasil analisis model pengukuran (outer model) dan analisis model structural (inner model). Model pengukuran bertujuan untuk untuk mengetahui hubungan antara indicator dan variabel, atau mengukur besar pengaruh indicator dalam menggambarkan variabel, dan model structural bertujuan untuk menggambarkan kekuatan dari estimasi antar konstruk, dan model pengukuran bertujuan untuk menggambarkan indicator dapat merepresentasikan variabel laten yang diukur. Hasil penelitian menunjukkan tingkat social ekonomi berpengaruh dengan pemilihan moda dengan nilai P Value 0.000, dan gender berpengaruh langsung terhadap pemilihan moda dengan nilai P Value 0.000. Tingkat social ekonomi berpengaruh signifikan tidak langsung terhadap pemilihan moda dengan faktor intervening keamanan dan kenyamanan. Sedangkan gender berpengaruh signifikan tidak langsung terhadap pemilihan moda melalu variabel intervening waktu, keamanan, dan kenyamanan.

Kata kunci— Pemilihan Moda Transportasi, Skala likert, Structural Equation Modeling (SEM), PLS
Analisis Risiko Penanggulangan Kebakaran (Studi Kasus Universitas Katolik De La Salle Manado)
Authors: Paat Denny , Tambas Arthur H , Umboh Markus K 
Published: March 2024

Kejadian kebakaran yang terjadi pada gedung dapat disebabkan oleh banyak faktor. Penanggulangan bahaya kebakaran diperlukan dalam setiap manajemen bangunan. Penelitian ini menggunakan metode Principal Component Analysis untuk menganalisis risiko kebakaran pada gedung Universitas Katolik De La Salle Manado. Berdasarkan hasil penelitian, teridentifikasi 4 komponen faktor yang sudah diuji validasi risiko penyebab kebakaran. Komponen yang memiliki pengaruh penyebab tertinggi adalah komponen faktor manusia dan teknis dengan nilai 31,043 %. Dalam komponen ini terdiri dari kurangnya pengawasan dari pimpinan, peralatan alat pemadam yang tidak sesuai spesifikasi, jaringan pengkabelan yang kurang baik, ketidakpedulian serta pemahaman yang kurang mengenai prinsip dasar pencengahan kebakaran. Nilai selanjutnya diikuti oleh komponen faktor alam dan teknis dengan besar 23,419 % yang terdiri dari penyebab kebakaran karena unsur kesengajaan, panas ektrim, hujan lebat dan angin kencang. Pengaruh ketiga yaitu alam dan teknis dengan persentase 15,581 dan yang terakhir komponen yang disebabkan oleh human eror dengan besar persentase 8,423 %. Risiko yang dihasilkan kemudian dianalisis akar penyebabnya dengan menggunakan metode Fault Analysis Methode (FTA) sehingga bisa dianalisis strategi penanganan riskonya.

Kata kunci : Risiko, kebakaran, principal componen analysis, fault analysis methode.
Unilateral Periorbital Necrotizing Fasciitis – A Case Report
Authors: Trepka-Sirek Barbara , Sirek Sebastian , Mrukwa-Kominek Ewa , Niedzielska Iwona 
Published: March 2024

IntroductionPeriorbital necrotizing fasciitis is rare due to the excellent blood supply to the area, but nevertheless can sometimes lead to death. Knowledge of the symptoms of the disease enables rapid diagnosis, which reduces the possibility of serious complications of the disease and its mortality. To date, few publications describing the disease entity have been presented.Patient descriptionA 70-year-old male patient was admitted to the hospital with necrotizing fasciitis of the left upper eyelid region, diagnosed on the basis of fulminant development of necrosis and a positive bacteriological test for S. pyogenes.ResultsContrast-enhanced computed tomography showed the presence of a pathological inflammatory infiltrate within the eyelid of the left eye and subcutaneous tissue at the preseptal level of the orbit and left cheek. Blood tests showed leukocytosis (total white blood cell count of 17.33 x 109/ L with 87.1% neutrophils) and elevated C reactive protein parameters (240.64 mg/ L). Empirical intravenous antibiotic therapy was administered: 1 g of amoxicillin with 200 mg of clavulanic acid every 8 hours, 500 mg of metronidazole every 8 hours, and ciprofloxacin into the left and right conjunctival sacs 3 mg/ml every 6 hours. Surgical debridement of upper eyelid necrosis was performed on the second day of hospitalization.ConclusionsThe peculiar anatomical structure of the periocular region promotes the dynamic development of necrotizing fasciitis. The close proximity of the central nervous system and the eyeball threatens irreversible consequences, including loss of vision or death. Early appropriate targeted treatment can effectively stop the development of the disease and prevent severe complications.
Legislation for Video­‑Sharing Platforms on the European Audiovisual Market
Authors: Grzesiok-Horosz Agnieszka 
Published: March 2024

The progressing convergence of television and Internet services has caused a dynamic development of the audiovisual market. The decision to regulate the subject matter of video-sharing platforms (VSPs) in the amended Audiovisual Media Services Directive (AVMSD) was dictated by recognition that such platforms compete for the same viewers and incomes as other audiovisual media services. Coordination of legislation on the European level led to the necessity to introduce amendments to Polish law. The main purpose of this article is to present selected provisions of AVMSD and Poland’s Broadcasting Act concerning VSPs as an area of media policy, which previously had fallen outside the scope of institutional intervention and regulatory restrictions relating to the traditional media market. The central question that author attempted to resolve was whether measures used in relation to VSP providers are legitimate, necessary and proportional. The study explains the definition of video delivery services which is fundamental from the point of view of imposing some obligations on these types of services.
Peningkatan Kemampuan Menulis dengan Menggunakan pendekatan keterampilan Proses untuk Siswa Sekolah Dasar
Authors: Rahayu Sri , Rosdiana  
Published: March 2024

Penelitian ini bertujuan untuk meningkatkan kualitas pembelajaran. Kualitas pembelajaran yang ditingkatkan dalam penelitian ini meliputi aktivitas dan hasil belajar peserta didik. Penelitian ini adalah Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam dua siklus. Subjek penelitian yaitu peserta didik kelas IV SDIP Assunnah Tamalate Makassar tahun pelajaran 2020/2021. Data yang diperoleh dalam penelitian ini adalah kuantitatif. Teknik pengumpulan data yang digunakan yaitu teknik tes dan non tes. Instrumen penelitian yang digunakan meliputi Rencana Pelaksanaan Pembelajaran (RPP), instrumen tes, dan instrumen non tes. Teknis analisis data yang digunakan penghitungan skor tes pilihan ganda,menentukan rata-rata kelas, dan persentase tuntas belajar. Nilai akhir pada tes formatif berbentuk pilihan ganda diperoleh dengan cara membagi jumlah jawaban benar dengan jumlah keseluruhan butir soal kemudian dikalikan seratus. Persentase aktivitas belajar peserta didik pada siklus I sebesar 66,67% atau 20 murid berada dalam kategori tuntas dan sebanyak 10 orang atau 33,33% berada dalam kategori tidak tuntas. Pada siklus II sebesar 100% atau 30 murid berada dalam kategori tuntas dan tidak ada lagi atau 0% berada dalam kategori tidak tuntas. Hasil aktivitas penelitian tersebut diatas membuktikan bahwa hasil belajar Bahasa Indonesia materi menulis paragraf pada peserta didik kelas IV SDIP Assunnah, Makassar melalui penerapan pendekatan keterampilan proses mengalami peningkatan. Peneliti memberikan saran untuk peningkatan kualitas pembelajaran. Saran yang diberikan oleh peneliti ditujukan untuk guru dan sekolah
S.Wahyuni Analisis Program Pembelajaran Tatap Muka (PTM) Terbatas pada Siswa Sekolah Dasar
Authors: Wahyuni Sri , H.M Arief  , Hisbullah  
Published: March 2024

Penyebaran virus covid-19 di awal tahun 2022 tersebar sangat cepat di penjuru dunia salah satunya Negara Indonesia teruama dibidang pendidikan, walaupun kondisi covid 19 pendidikan harus tertap berjalan agar anak-anak emas tidak ketinggalan dalam pembelajaran sehingga pemerintah menetapkan aturan pembelajaran tatap muka terbatas. Penelitian ini fokus pada mengetahui bagaimana perencanaan, pelaksanaan,evaluasi pembelajaran serta faktor pendukung dan penghambat dari program tatap muka terbatas siswa sekolah dasar.Penelitian ini menggunakan jenis penelitian deskriptif kualitatif. Teknik pengumpulan data dilakukan dengancara observasi, wawancara, dan dokumentasi. Teknik analisis data dilakukan dengan cara pengumpulan data, kondensasi data, penyajian data dan verifikasi atau penarikan kesimpulan. Adapun subjek penelitian ini adalah kepala sekolah dan 3 orang wali kelas pada kelas V SDN 1 Lalebbata. Hasil penelitian adalah perencanaan guru harus mempersiapkan administrasi guru sesuai dengan kondisi yang dialami seperti kalender pendidikan, promes, prota, silabus, RPP, buku absen, KKM, daftar nilai, buku paket, bahan ajar, dan tata tertib kelas. Untuk pelaksanaan pembelajaran setiap kelas membagi peserta didiknya menjadi dua bagian, ada yang shift pagi masuk pada pukul 07.30-09.00 dan untuk shift siang masuk pada pukul 09.30-11.00.Kegiatan guru terbatas sehingga guru hanya menyampaikan point-point penting materi tersebut guru juga tidak melakukan beberapa langkah pembelajaran didalam kelas yaitu guru tidak menyampaikan alokasi waktu pembelajaran, guru tidak menyediakan media pembelajaran yang menarik dan guru tidak menerapkan strategi pembelajaran secara berkelompok. Untuk evaluasi pembelajaran guru melakukan ulangan harian dan tugas-tugas harian seperti biasanya dan hasil belajar peserta didik juga membaik jika dibandingkan dengan pembelajaran yang dilakukan dirumah. Adapun program pembelajaran tatap muka terbatas yang seharusnya yaitu peneliti menggagas 6 langkah baru yaitu 1) Guru menyampaikan materi dengan cara menggunakan metode pembelajaran yang dapat menarik minat belajar peserta didik, 2) Guru memberikan materi pembelajaran yang berpusat kepada peserta didik, 3) Guru mengevaluasi pemahaman peserta didik, 4) Guru merancang rubrik penilaian 5) Guru berperan sebagai motivator, 6) Guru sebagai penyedia pengalaman belajar.
Problematika Pembelajaran Daring pada Masa Pandemi Covid 19 di Sekolah Dasar
Authors: Musbaing  
Published: March 2024

Penelitian ini bertujuan, untuk mengetahui problematika pembelajaran daring pada masa pandemi Covid 19 pada pembelajaran tematik di kelas IV SD Inpres Bakung 2 Kota Makassar. Penelitian ini dilaksanakan di SD Inpres Bakung 2 Kota Makassar. Menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Subjek dalam penelitian ini adalah guru kelas IV SD Inpres Bakung 2 Kota Makassar, adapun sumber data terdiri dari informan utama dan informan pendukung. Aktivitas dalam analisis data yaitu data reduction, data display, conclusion daring/verification. Untuk uji keabsahan data meliputi triangulasi sumber, triangulasi teknik, dan triangulasi waktu. Hasil penelitian ini menunjukkan bahwa problematika pembelajaran daring pada pembelajaran tematik yaitu kurangnya pemahaman guru tentang inovasi pembelajaran daring dan kurang kreatifnya seorang guru menyediakan media yang mampu menarik dan membangkitkan motivasi belajar siswa. Selama pembelajaran daring berlangsung guru hanya menggunakan whatsapp group dengan mengirim foto tugas terkait materi yang dipelajari. Adapun upaya untuk mengatasi problematika ini guru harus mempunyai kesadaran untuk menyediakan media yang menarik, dan menciptakan strategi kelas yang aktif, inovasi, kreatif dan efektif.
Penanaman Nilai-Nilai Karakter dan Budaya Melalui Permainan Tradisional Pada Siswa Sekolah Dasar
Authors: Cahyani Amelia Putri , Oktaviani Devi , Ramadhani Putri Salma , Kamilah Sofi Nur , Caturiasari Jennyta , Wahyudin Dede 
Published: March 2024

Permainan tradisional merupakan permainan turun menurun dari nenek moyang akan tetapi permainan tradisonal sudah tersisihkan dikarenakan di zaman era modern penggunaan teknelogi sangat digunakan untuk kehidupan sehari-hari. Teknelogi yang selalu digunakan untuk komunikasi yaitu handphone. Handphone biasanya digunakan oleh anak-anak untuk bermain game online karena anak-anak bisa bermain game online di mana saja dan kapan pun, yang mengakibatkan anak-anak tidak bermain dengan teman sebayanya karena sudah asik dan fokus dengan game online yang ada di handphone. Di zaman era modern anak-anak kurang interaksi sosial di lingkungan sekitar yang mengakibatkan anak-anak memiliki rasa kurang percaya diri, menyendiri, dan pemalu diakibatkan oleh game oline yang ada di handphone dan kurang pembatasan waktu bermain game online oleh orang tua. Cara menanamkan nilai-nilai karakter budaya untuk siswa dengan melalui permainan tradisional karena permainan tradisional dapat membentuk jiwa berkerja sama, gotong royong, disiplin, dan tanggung jawab. Penelitian ini menggunakan metode kualitatif dengan kajian studi literatur. Peneliti sudah menganalisis permaianan tradisonal bisa memiliki nilai-nilai karakter budaya untuk siswa SD seperti: kemampuan sosial, etika dan moral, kemampuan emosional, dan penguatan identitas budaya.
Kilometre-scale simulations over Fennoscandia reveal a large loss of tundra due to climate warming
Authors: Lagergren Fredrik , Björk Robert G. , Andersson Camilla , Belušić Danijel , Björkman Mats P. , Kjellström Erik , Lind Petter , Lindstedt David , Olenius Tinja , Pleijel Håkan , Rosqvist Gunhild , Miller Paul A. 
Published: March 2024

Abstract. The Fennoscandian boreal and mountain regions harbour a wide range of vegetation types, from boreal forest to high alpine tundra and barren soils. The area is facing a rise in air temperature above the global average and changes in temperature and precipitation patterns. This is expected to alter the Fennoscandian vegetation composition and change the conditions for areal land use such as forestry, tourism and reindeer husbandry. In this study we used a unique high-resolution (3 km) climate scenario with considerable warming resulting from strongly increasing carbon dioxide emissions to investigate how climate change can alter the vegetation composition, biodiversity and availability of suitable reindeer forage. Using a dynamical vegetation model, including a new implementation of potential reindeer grazing, resulted in simulated vegetation maps of unprecedented high resolution for such a long time period and spatial extent. The results were evaluated at the local scale using vegetation inventories and for the whole area against satellite-based vegetation maps. A deeper analysis of vegetation shifts related to statistics of threatened species was performed in six “hotspot” areas containing records of rare and threatened species. In this high-emission scenario, the simulations show dramatic shifts in the vegetation composition, accelerating at the end of the century. Alarmingly, the results suggest the southern mountain alpine region in Sweden will be completely covered by forests at the end of the 21st century, making preservation of many rare and threatened species impossible. In the northern alpine regions, most vegetation types will persist but shift to higher elevations with reduced areal extent, endangering vulnerable species. Simulated potential for reindeer grazing indicates latitudinal differences, with higher potential in the south in the current climate. In the future these differences will diminish, as the potentials will increase in the north, especially for the summer grazing grounds. These combined results suggest significant shifts in vegetation composition over the present century for this scenario, with large implications for nature conservation, reindeer husbandry and forestry.
MẪN CẢM CHÉO VÀ PHẢN ỨNG DA LIÊN QUAN TỚI THUỐC CHỐNG ĐỘNG KINH CÓ VÒNG THƠM
Authors: Khiêm Nguyễn Văn , Hương Lê Thị Minh , Quang Vũ Văn , Đĩnh Nguyễn Văn 
Published: March 2024

Động kinh là một bệnh lý hay gặp của hệ thần kinh. Tỷ lệ bệnh nhân động kinh ước tính khoảng 1% dân số. Các thuốc chống động kinh (AEDs - antiepileptic drugs) giúp kiểm soát tốt các cơn động kinh, tuy nhiên một số phản ứng quá mẫn với AEDs cũng đã được ghi nhận. Các tác dụng phụ của AEDs gồm có các biểu hiện sớm (buồn ngủ, chóng mặt, các biểu hiện ở dạ dày ruột, thậm chí làm co giật nặng lên) và các biểu hiện muộn (các đợt loạn thần, các rối loạn hành vi, trầm cảm, suy giảm nhận thức, loãng xương, giảm bạch cầu). Các phản ứng trên da thuộc nhóm các biểu hiện sớm, từ các phản ứng nhẹ như phát ban da (MPE), tới các phản ứng da nặng (SCARs) bao gồm Hội chứng Steven-Johnson (SJS), hoại tử thượng bì nhiễm độc (TEN), phản ứng với thuốc có triệu chứng toàn thân có tăng bạch cầu ái toan (DRESS) và ban mụn mủ cấp tính toàn thân (AGEP).
Việc sử dụng các thuốc chống động kinh có vòng thơm (aromatic) như Carbamazepine, Oxcarbazepine, Phenytoin, Phenobarbital, Lamotrigine, Primidone và Zonisamide thường có liên quan tới phát ban trên da và các triệu chứng, dấu hiệu khác của quá mẫn do thuốc. Bệnh nhân bị phản ứng dị ứng hoặc quá mẫn với AEDs có tỷ lệ mẫn cảm chéo cao (40-80%), điều này gợi ý rằng cần tránh các thuốc chống động kinh có cấu trúc hóa học tương đồng ở những quần thể có nguy cơ cao.