bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin in the mammalian retina: Synthesis, mechanisms of action and neuroprotection
Authors: Felder‐Schmittbuhl Marie Paule , Hicks David , Ribelayga Christophe P. , Tosini Gianluca 
Published: April 2024

AbstractMelatonin is an important player in the regulation of many physiological functions within the body and in the retina. Melatonin synthesis in the retina primarily occurs during the night and its levels are low during the day. Retinal melatonin is primarily synthesized by the photoreceptors, but whether the synthesis occurs in the rods and/or cones is still unclear. Melatonin exerts its influence by binding to G protein‐coupled receptors named melatonin receptor type 1 (MT1) and type 2 (MT2). MT1 and MT2 receptors activate a wide variety of signaling pathways and both receptors are present in the vertebrate photoreceptors where they may form MT1/MT2 heteromers (MT1/2h). Studies in rodents have shown that melatonin signaling plays an important role in the regulation of retinal dopamine levels, rod/cone coupling as well as the photopic and scotopic electroretinogram. In addition, melatonin may play an important role in protecting photoreceptors from oxidative stress and can protect photoreceptors from apoptosis. Critically, melatonin signaling is involved in the modulation of photoreceptor viability during aging and other studies have implicated melatonin in the pathogenesis of age‐related macular degeneration. Hence melatonin may represent a useful tool in the fight to protect photoreceptors—and other retinal cells—against degeneration due to aging or diseases.
Longitudinal associations of meeting the WHO physical activity guidelines and physical fitness, from preschool to childhood
Authors: Tigerstrand Grevnerts Hanna , Delisle Nyström Christine , Migueles Jairo Hidalgo , Löf Marie 
Published: April 2024

AbstractThere is a well‐established relationship between physical activity (PA) and physical fitness in children, being the latter an important marker for present and future health; however, there is still insufficient knowledge for the transition from the preschool age to early childhood. Therefore, this study in Swedish children aimed to investigate the estimated effect of meeting the aerobic component of the PA guidelines at 4 and/or 9 years of age on physical fitness measured at 9 years of age. PA was assessed using a wrist‐worn ActiGraph accelerometer and identical data processing in 217 healthy children in Sweden (114 boys and 103 girls). Physical fitness test included cardiorespiratory (20 m shuttle run test), motor (4 × 10 m shuttle run), and muscular fitness (hand grip strength and long jump). A linear mixed model was run, investigating the interaction between meeting the PA guidelines and time (either 4 or 9 years of age) and each fitness component (at 4 and 9). Interactions by sex were also checked. Meeting the PA guidelines consistently (at 4 and 9 years) was significantly associated to better performance in physical fitness parameters for motor fitness (−0.76 s, p < 0.001) and lower body muscular fitness (+4.6 cm; p < 0.001) at 9 years. There was an interaction between meeting the PA guidelines and time point, for cardiorespiratory fitness (+4.58 laps; p < 0.001). This study shows that meeting the PA guidelines at 4 and 9 years of age is associated to higher physical fitness at 9 years of age.
Since you put it that way… Gender norms and interruptions at Supreme Court oral arguments
Authors: Gleason Shane A. 
Published: April 2024

AbstractObjectiveAt U.S. Supreme Court oral arguments, female attorneys are more likely to be interrupted than their male counterparts under some conditions. This makes it difficult for women to effectively construct a narrative and substantively impact case law. While existing work conceptualizes gender as a binary, I draw on recent work stressing gender is performative to deesentialize gender and explore how attorneys’ compliance with gender norms and subtle expectations about men's and women's behavior in a host of contexts, predicts interruptions at oral arguments.MethodsVia quantitative textual analysis of all oral arguments from 2004 to 2019 where one attorney argues for the petitioner and one for the respondent, I examine the extent to which gender norm compliance predicts interruptions.ResultsI find both male and female attorneys are interrupted more frequently when their oral arguments are not gender normative. Thus, an argument that is successful for a male attorney is not necessarily successful for a female attorney, and vice versa.ConclusionMy results underscore female attorneys are not less successful as a matter of course; attorney success is driven by attorney compliance with gender norms. This work also raises a number of normative questions I encourage future scholars to explore.
Inhibition of the RLR signaling pathway by SARS-CoV-2 ORF7b is mediated by MAVS and abrogated by ORF7b-homologous interfering peptide
Authors: Xiao Xiao , Fu Yanan , You Wanling , Huang Congcong , Zeng Feng , Gu Xinsheng , Sun Xiaoguang , Li Jian , Zhang Qiwei , Du Weixing , Cheng Gong , Liu Zhixin , Liu Long 
Published: April 2024

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and characterized by dysregulated immune response. Studies have shown that the SARS-CoV-2 accessory protein ORF7b induces host cell apoptosis through the tumor necrosis factor alpha (TNF-α) pathway and blocks the production of interferon beta (IFN-β). The underlying mechanism remains to be investigated. In this study, we found that ORF7b facilitated viral infection and production, and inhibited the RIG-I-like receptor (RLR) signaling pathway through selectively interacting with mitochondrial antiviral-signaling protein (MAVS). MAVS
439-466
region and MAVS Lys461 were essential for the physical association between MAVS and ORF7b, and the inhibition of the RLR signaling pathway by ORF7b. MAVS
K461
/K63 ubiquitination was essential for the RLR signaling regulated by the MAVS–ORF7b complex. ORF7b interfered with the recruitment of tumor necrosis factor receptor-related factor 6 (TRAF6) and the activation of the RLR signaling pathway by MAVS. Furthermore, interfering peptides targeting the ORF7b complex reversed the ORF7b-suppressed MAVS-RLR signaling pathway. The most potent interfering peptide V disrupts the formation of ORF7b tetramers, reverses the levels of the ORF7b-inhibited physical association between MAVS and TRAF6, leading to the suppression of viral growth and infection. Overall, this study provides a mechanism for the suppression of innate immunity by SARS-CoV-2 infection and the mechanism-based approach via interfering peptides to potentially prevent SARS-CoV-2 infection.

IMPORTANCE
The pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and continues to be a threat to public health. It is imperative to understand the biology of SARS-CoV-2 infection and find approaches to prevent SARS-CoV-2 infection and ameliorate COVID-19. Multiple SARS-CoV-2 proteins are known to function on the innate immune response, but the underlying mechanism remains unknown. This study shows that ORF7b inhibits the RIG-I-like receptor (RLR) signaling pathway through the physical association between ORF7b and mitochondrial antiviral-signaling protein (MAVS), impairing the K63-linked MAVS polyubiquitination and its recruitment of tumor necrosis factor receptor-related factor 6 (TRAF6) to MAVS. The most potent interfering peptide V targeting the ORF7b–MAVS complex may reverse the suppression of the MAVS-mediated RLR signaling pathway by ORF7b and prevent viral infection and production. This study may provide new insights into the pathogenic mechanism of SARS-CoV-2 and a strategy to develop new drugs to prevent SARS-CoV-2 infection.
Impact of multiple weak layers on deformation of the interior of Qaidam Basin, northern Tibetan Plateau
Authors: Yang Huitong , Tan Wei , Wu Lei , Zhang Yongshu , Wang Bo , Zhang Junyong , Wei Xuebing , Tang Pengcheng , Mao Liguang , Wang Chuanwu , Chen Yan , Tang Jianchao , Huang Kai , Xiao Ancheng , Lin Xiubin , Chen Hanlin 
Published: April 2024

Abstract
The Qaidam Basin is the largest sedimentary basin within the Tibetan Plateau, with up to ~15-km-thick deposits accumulated in the Cenozoic. Understanding how it deformed in response to the far-field effects of India-Eurasia collision is critical to improving our knowledge of the mechanism underlying northward plateau growth. Unlike typical compressional basins, where upper-crustal deformation concentrates at their margins, the Qaidam Basin features the development of many NW- to WNW-striking folds across the entire basin. Why crustal shortening occurred in the interior of Qaidam Basin, ~100 km away from the margins, together with the underground geometries beneath these folds, remains unknown. Herein, based on newly acquired three- and two-dimensional (3-D and 2-D) seismic reflection data, borehole logging, and scaled physical analog modeling, we investigated the geometries, kinematics, and formation mechanisms of the folds within the interior of Qaidam Basin. For the first time, we reveal three local weak layers in the Lulehe, Upper Xiaganchaigou, and Shangyoushashan Formations, respectively. They consist mainly of mudstone intercalated with evaporites and limestones, and they have different spatial distributions that are likely confined by major faults and folds. These mechanically weak layers became locally thickened or thinned in response to tectonic loading and/or facilitated detachment slip to form many décollement folds that were observed at the surface. The shallow deformation above the weak layers is largely decoupled from underlying basement-involved faulting and folding, which mostly terminate upward in these weak layers. Analog modeling results suggest that the lowermost and widely distributed décollement layer in the Lulehe Formation likely facilitated long-distance rapid propagation of deformation into the basin interior. In sum, our study highlights the significance of multiple weak layers during Cenozoic deformation in the Qaidam Basin interior.
The effects of weathering and sediment source mixing on whole-rock geochemical provenance studies, Cook Inlet forearc basin, south-central Alaska, USA
Authors: Kapolas A. , Finzel E.S. , Horkley L.K. , Peate D.W. 
Published: April 2024

Abstract
The provenance of most basin systems today is interpreted based on radiogenic ages or the geochemical composition of detrital minerals, which has all but replaced the use of whole-rock geochemical approaches that can effectively complement provenance information inferred from detrital approaches. Here, we further investigate previous provenance models developed using detrital zircon U-Pb geochronology by applying whole-rock major and trace element geochemistry of fine-grained clastic rocks from the late Oligocene–middle Miocene Tyonek Formation, late Miocene Beluga Formation, and Pliocene Sterling Formation in the Cook Inlet Basin, Alaska, USA. When taken alone, our new geochemical data suggest solely intermediate igneous sediment sources to the basin. When paired with existing detrital zircon U-Pb data, however, significant mixing of felsic and mafic sediment sources is evident, which indicates that thorough mixing of geochemically distinct source terranes can mask the input from individual sources in whole-rock geochemical studies. Furthermore, we demonstrate that both weathering and provenance influence the major element chemistry of sediment source terranes as well as the resultant basinal strata. Our conclusions indicate that the combination of whole-rock geochemistry with other detrital approaches provides a robust interpretation of sedimentary basin provenance.
The Permian Cornubian granite batholith, SW England; Part 1: Field, structural, and petrological constraints
Authors: Searle Michael P. , Shail Robin K. , Pownall Jonathan M. , Jurkowski Christopher , Watts Anthony B. , Robb Laurence J. 
Published: April 2024

Abstract
The Permian Cornubian granite batholith (295–275 Ma) in SW England includes seven major plutons and numerous smaller stocks extending for ~250 km from the Isles of Scilly in the WSW to Dartmoor in the ENE. The granites are peraluminous and classified as crustal melt S-type, predominantly two-mica granites, and biotite or tourmaline monzo- and syenogranites, with subordinate minor topaz granite and lithium mica granite. The granites and their host rocks are pervasively mineralized with tin (cassiterite), tungsten (wolframite, ferberite), copper (chalcopyrite, chalcocite, bornite), arsenic (arsenopyrite), and zinc (sphalerite) mineralized lodes. Quartz-muscovite selvedges (greisen-bordered) also contain enrichment of lithophile elements such as boron (tourmaline), fluorine (fluorite), and lithium (lithium-micas such as lepidolite and zinnwaldite). They are derived from both muscovite and biotite dehydration melting of pelitic-psammitic rocks and intruded from a common source along the length of the batholith. Pressure estimates from andalusite and cordierite-bearing hornfels in the contact metamorphic aureole (150 ± 100 MPa) show that the granites intruded to 3 km depth. Cupolas around the Land's End and Tregonning granites show aplite-pegmatite dikes and tourmaline + quartz + muscovite veins (greisen) that are frequently mineralized. Synchronous intrusions of lamprophyre dikes suggest an additional heat source for crustal melting may have been from underplating of alkaline magmas. The lack of significant erosion means that the source region is not exposed. In an accompanying paper (Part 2; Watts et al., 2024), gravity modeling reveals possible solutions for the shape and depth of the granite and the structure of the lower crust. We present a new model for the Land's End, Tregonning, and Carnmenellis granites showing a mid-crustal source composed of amphibolite facies migmatites bounded by prominent seismic reflectors, with upward expanding dikes feeding inter-connected granite laccoliths that show inflated cupolas with shallow contact metamorphism. The Cornubian granites intruded &gt;90 m.y. after obduction of the Lizard ophiolite complex, and after Upper Devonian–Carboniferous Variscan compressional, and later extensional, deformation of the surrounding Devonian country rocks. Comparisons are made between the Cornubian batholith and the Patagonian batholith in Chile, the Himalayan leucogranites, and the Baltoro granite batholith along the Karakoram range in northern Pakistan.
Suicide in National Collegiate Athletic Association athletes: a 20-year analysis
Authors: Whelan Bridget M , Kliethermes Stephanie A , Schloredt Kelly A , Rao Ashwin , Harmon Kimberly G , Petek Bradley J 
Published: April 2024

ObjectivesTo determine the incidence rate of suicide from 2002 to 2022 among athletes from the National Collegiate Athletic Association (NCAA) and assess for potential differences by, sex, race, division and sport.MethodsNCAA athlete deaths over a 20-year period from 2002 to 2022 were identified. Poisson regression models were built to assess changes in incidence rates over time. Linear and quadratic fits between year and suicide incidence for males and females were evaluated.ResultsOf 1102 total deaths, 128 (11.6%) deaths by suicide were reported (male n=98, female n=30). The overall incidence was 1:71 145 athlete-years (AYs). Over the last decade, suicide was the second most common cause of death after accidents. The proportion of deaths by suicide doubled from the first 10 years (7.6%) to the second 10 years (15.3%). The suicide incidence rate for males increased linearly (5-year incidence rate ratio 1.32 (95% CI 1.14 to 1.53)), whereas a quadratic association was identified among female athletes (p=0.002), with the incidence rate reaching its lowest point in females in 2010–2011 and increasing thereafter. Male cross-country athletes had the highest suicide incidence rate (1:29 815 AYs) and Division I and II athletes had a higher suicide incidence rate than Division III athletes. No significant differences in suicide incidence rates by sex, race or sport were identified.ConclusionDeaths by suicide among NCAA athletes increased in both males and females throughout the 20-year study period, and suicide is now the second most common cause of death in this population. Greater suicide prevention efforts geared towards NCAA athletes are warranted.
TENDINopathy Severity assessment–Achilles (TENDINS-A): evaluation of reliability and validity in accordance with COSMIN recommendations
Authors: Murphy Myles Calder , McCleary Fergus , Hince Dana , Chimenti Ruth , Chivers Paola , Vosseller J Turner , Nimphius Sophia , Mkumbuzi Nonhlanhla Sharon , Malliaras Peter , Maffulli Nicola , de Vos Robert-Jan , Rio Ebonie Kendra 
Published: April 2024

ObjectiveTo evaluate the construct validity (structural validity and hypothesis testing), reliability (test–retest reliability, measurement error and internal consistency) and minimal important change (MIC) of the 13-item TENDINopathy Severity assessment–Achilles (TENDINS-A).MethodsParticipants with Achilles pain completed an online survey including: demographics, TENDINS-A, Foot and Ankle Outcome Score (FAOS) and Victorian Institute of Sport Assessment–Achilles (VISA-A). Exploratory factor analysis (EFA) assessed dimensionality. Confirmatory factor analysis (CFA) assessed structural validity (root mean square error of approximation (RMSEA); Comparative Fit Index (CFI); Tucker-Lewis Index (TLI); standardised root measure square (SRMS)). Correlations between TENDINS-A and the FAOS or VISA-A assessed hypothesis testing. Intraclass correlation (ICC) assessed test–retest reliability. Cronbach’s alpha assessed internal consistency. SE of the measurement (SEM) assessed measurement error. A distribution-based approach assessed MIC.Results79 participants (51% female) with a mean (SD) age=42.6 (13.0) years, height=175.0 (11.7) cm and body mass=82.0 (19.1) kg were included. EFA identified three meaningful factors, proposed as pain, symptoms and function. The best model identified using CFA for TENDINS-A had structural validity (RMSEA=0.101, CFI=0.959, TLI=0.947, SRMS=0.068), which included three factors (pain, symptoms and function), but excluded three items from the original TENDINS-A. TENDINS-A exhibited moderate positive correlation with FAOS (r=0.598, p<0.001) and a moderate negative correlation with VISA-A (r=−0.639, p<0.001). Reliability of the TENDINS-A was excellent (ICC=0.930; Cronbach’s α=0.808; SEM=6.54 units), with an MIC of 12 units.ConclusionsOur evaluation of the revised 10-item TENDINS-A determined it has construct validity and excellent reliability, compared with the VISA-A and FAOS which lack content and construct validity. The TENDINS-A is recommended as the preferred patient-reported outcome measure to assess disability in people with Achilles tendinopathy.
On the Impact of Lower Recall and Precision in Defect Prediction for Guiding Search-based Software Testing
Authors: Perera Anjana , Turhan Burak , Aleti Aldeida , Böhme Marcel 
Published: April 2024

Defect predictors, static bug detectors, and humans inspecting the code can propose locations in the program that are more likely to be buggy before they are discovered through testing. Automated test generators such as search-based software testing (SBST) techniques can use this information to direct their search for test cases to likely buggy code, thus speeding up the process of detecting existing bugs in those locations. Often the predictions given by these tools or humans are imprecise, which can misguide the SBST technique and may deteriorate its performance. In this article, we study the impact of imprecision in defect prediction on the bug detection effectiveness of SBST.
Our study finds that the recall of the defect predictor, i.e., the proportion of correctly identified buggy code, has a significant impact on bug detection effectiveness of SBST with a large effect size. More precisely, the SBST technique detects 7.5 fewer bugs on average (out of 420 bugs) for every 5% decrements of the recall. However, the effect of precision, a measure for false alarms, is not of meaningful practical significance, as indicated by a very small effect size.
In the context of combining defect prediction and SBST, our recommendation is to increase the recall of defect predictors as a primary objective and precision as a secondary objective. In our experiments, we find that 75% precision is as good as 100% precision. To account for the imprecision of defect predictors, in particular low recall values, SBST techniques should be designed to search for test cases that also cover the predicted non-buggy parts of the program, while prioritising the parts that have been predicted as buggy.
Seneca’s Thyestes: Ode 920-969 as an Amoibaion
Authors: Słomak Iwona 
Published: April 2024

Abstract
This article aims to revise the editorial and interpretive tradition that regards Thy. 920-969 as a monody. Based on a systematic analysis of attribution differences in three selected plays by Seneca and, comparatively, in several other problematic places, it confirms earlier general findings: the A-branch of the MS tradition shows traces of conscious interpolation, while the codex Etruscus (E-branch) contains largely mechanical errors, which—in the case of Thy. 920-969—makes its attribution more plausible. The article further discusses the problematic passages of the ode that might have motivated interpolations, provides a critique of the interpretive assumptions supporting the A reading, and demonstrates that the attribution in the E-branch is correct in the light of the rules of Senecan poetics, as well as from the point of view of the internal logic of the text and the ethopoeia of the eponymous hero.
Underwater advertisement call of the threatened Telmatobius rubigo (Anura: Telmatobiidae)
Authors: Akmentins Mauricio Sebastián , Gastón María Soledad , Boullhesen Martín 
Published: April 2024

Abstract
Underwater Passive Acoustic Monitoring (UPAM) has been used infrequently to register subsurface vocal behaviour in anurans. This study describes the underwater advertisement call of Telmatobius rubigo based on recordings made with UPAM technique. Telmatobius rubigo call is a low-frequency trill composed of 6 to 22 pulses with amplitude modulation. The spectral and temporal characters showed differences from other Telmatobius species. The UPAM, combined with automated call identification software, showed effectiveness in monitoring the calling behaviour of this aquatic Andean frog in their natural environment. UPAM and soundscape/riverscape analysis should be incorporated as a non-invasive tool for monitoring threatened aquatic species.
Arctic Indigenous Peoples and International Law
Authors: Olsvig Sara , Cullen Miriam 
Published: April 2024

Abstract
Arctic Indigenous Peoples have, through their own persistence, advanced the development of the Western European legal norms in a system that once facilitated their colonisation. The fiftieth anniversary of the Arctic Peoples’ Conference took place in 2023. The occasion was marked with another Conference, this time in Ilulissat, Greenland. It was a moment to reflect on the achievements of Arctic Indigenous Peoples, to build upon the 1973 resolutions and to address contemporary challenges. The resultant Joint Statement addresses the need for enhanced engagement in the forums of international law, intergenerational justice, intersecting rights to wellbeing, land, water and natural resources, and to address the risks posed by climate change and colonialism.