bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan LKPD menggunakan pendekatan kontekstual pada materi teorema phytagoras
Authors: Royan Salsabila Zayyana , Supriatna Tatang 
Published: February 2024

This study aims to determine: the process of developing LKPD, the feasibility of the developed LKPD, the effectiveness of the LKPD and the constraints encountered when developing LKPD using the Contextual approach. The method used is research and development which is modified from the R&D research and development model through the 4D stages (Define, Design, Develop, Dessiminate). This research was conducted at Bina Mulia Mandiri Middle School with research subjects in limited trials, namely 15 students and 30 students as subjects in a wide trial. The results showed that the feasibility of teaching materials was categorized as very feasible and practical for use at Bina Mulia Mandiri Middle School based on the results of the validator and student response questionnaires. The obstacles that were encountered during the implementation of the research were that it was difficult for students to change their study habits so far, that is, they just sat watching the teacher explain, students sometimes ignored the instructions from the researcher.
Effects of eruption guidance appliance in the early treatment of Class III malocclusion
Authors: Velásquez Gonzalo , Aliaga-Del Castillo Aron , Valerio Marcelo Vinicius , Maranhão Olga Benário Vieira , Miranda Felicia , Janson Guilherme 
Published: February 2024

ABSTRACT

Objectives
To evaluate the dentoskeletal effects and effectiveness of the eruption guidance appliance in Class III patients in the mixed dentition.

Materials and Methods
The experimental group comprised 22 patients with Class III malocclusion and anterior cross-bite (12 males, 10 females, mean age 7.63 ± 0.96 years) treated with the eruption guidance appliance over a mean period of 1.72 ± 0.48 years. The control group comprised 22 untreated subjects (12 males, 10 females, mean age 7.21 ± 0.60 years) with Class III malocclusion. Lateral cephalometric radiographs were obtained at pretreatment (T1) and posttreatment (T2). Intergroup comparisons were performed with Mann-Whitney and t-tests (P &lt; .05).

Results
In the experimental and control groups, the anteroposterior relationship between the maxilla and mandible (ANB angle) remained stable during the treatment period (T1 to T2). The mandibular plane angle decreased in the experimental group and increased in the control group. In the experimental group, the lower anterior face height increase and maxillary molar vertical development were significantly smaller compared to controls. Positive overjet was achieved in 54% of the experimental group.

Conclusions
The eruption guidance appliance produced no change in the skeletal anteroposterior relationship. The anterior cross-bite/edge-to-edge relationship was corrected in only about half of the treated subjects.
Economic Crises in Recent World History: Analysis of Causes and Assessment of Consequences
Authors: Meshcheryakova A. B. 
Published: February 2024

The study «Economic Crises in History: Analysis and Consequences» provides a comprehensive overview of significant economic crises spanning different periods and regions of world history. The work extensively examines the following events: the Great Depression (1929–1933), the Asian Financial Crisis (1997), the Financial Crisis of 2008, the Eurozone Debt Crisis (2010–2012), the Crisis in Russia (1998), and the Oil Crisis of the 1970s.Each crisis is analyzed in terms of its causes, characteristics, impact on the economy and society, as well as measures taken to overcome its consequences. The study emphasizes the role of crises in correcting imbalances, stimulating innovations, and restructuring industries. Specific figures, such as unemployment rates, GDP contractions, changes in financial markets, and other economic indicators, are discussed within the context of each crisis.In the conclusion of the study, it is underscored that despite their complexity and negative consequences, crises can serve as catalysts for change, fostering structural reforms, improving efficiency, and contributing to the development of a resilient economy in the long term.
¿Difusión o cogeneración de conocimiento en Agroecología?
Authors: Reyes-Neuhauser María Victoria 
Published: February 2024

A partir de su tesis doctoral, la autora desarrolla este artículo a fin de analizar más a fondo las respuestas encontradas a una de las preguntas centrales de dicho trabajo: a partir de los resultados del trabajo de campo llevado a cabo en tres experiencias de sistemas en transición de la Región Metropolitana de Buenos Aires, ¿qué modalidades de circulación de conocimiento en técnicas agroecológicas fueron puestas en juego y parecen haber prevalecido?
Para ese fin, cita autores y presenta definiciones de estos conceptos de modo sucinto, los cuales derivan de dos corrientes distintas en la Extensión Rural, que se han presentado muchas veces como contrapuestas: la “visión transferencista” versus las modalidades que apuestan a un conocimiento generado de modo conjunto por los diversos actores intervinientes en los procesos de transición agroecológica (paradigma constructivista).
El artículo presenta una reflexión acerca de la necesidad de analizar con cuidado la diferenciación de ambas modalidades, tomando en consideración que ha habido una tendencia entre los extensionistas a considerar que la mayoría de las experiencias realizadas recientemente – en especial en experiencias agroecológicas- ocurrieron según una modalidad de circulación de conocimiento cogenerado entre productores y extensionistas.
Además, ha habido una tendencia a sobrevalorar las posibilidades de los enfoques de tipo “agricultor a agricultor”, que han sido ampliamente utilizados en las experiencias de transición agroecológica. La autora analiza, de modo crítico, esas modalidades y da argumentos para debatir acerca de esos supuestos, a fin de contribuir a la reflexión sobre estas prácticas de la Extensión Rural recientemente.
Genome-Wide Association Study for Meat Quality Traits in a Multi-Breed Pig Population
Authors: Kamiński Stanisław , Tarczyński Krystian , Oleński Kamil , Zybert Andrzej , Sieczkowska Halina , Krzęcio-Nieczyporuk Elżbieta , Antosik Katarzyna , Szwaczkowski Tomasz 
Published: February 2024

Abstract
This study aimed at identifying genomic regions that affect nine pork quality traits in purebred and crossbred fatteners. A total of 259 fatteners represented by six purebreds/crosses were genotyped for 45556 SNP markers by Illumina Porcine SNP60 BeadChip. The following traits were recorded: glycogen potential (GP), glycogen content (GC), lactate content (LC), pH35, pH24, pH48, drip loss after 48 hours (DL48), colour lightness (L
*) and lean meat content (LMC). Multi-Locus Mixed Model methodology was applied to find associations between SNP markers and recorded traits. Several SNPs were found to be significantly associated with some pork quality traits: four SNPs (located on SSC7, SSC10 and SSC14) with GP, three SNPs (SSC10, SSC14) with GC, one SNP (SSC15) with DL48 and one SNP with pH48. Genetic variation explained by significant SNPs ranged from 7.6% to 9.1%. Moreover, some genes (e.g. CAPN10, ALDH5A1, PASK, SNITA1 and MYH7B) located in the close vicinity to significant markers are proposed to be candidate genes explaining the genetic background of the traits studied.
Gene Expression Level and Immunohistochemical Localization of Cannabinoid and Cannabinoid-Related Receptors in The Small Intestine of Holstein Bulls (Bos Taurus Taurus)
Authors: Osiak-Wicha Cezary , Muszyński Siemowit , Tomaszewska Ewa , Kras Katarzyna , Ropka-Molik Katarzyna , Zhyla Mykola , Arciszewski Marcin Bartłomiej 
Published: February 2024

Abstract
The gastrointestinal tract plays a crucial role in nutrient absorption, secretion, and motility, ensuring proper digestion and overall homeostasis. Regulation of this complex system involves the coordination of various communication pathways, including neural and humoral mechanisms. One such mechanism is the endocannabinoid system (ECS), a signaling network comprising endogenous cannabinoids, receptors, and enzymes involved in the regulation of physiological processes in mammals and non-mammalian species. While extensive research has been conducted on the ECS in monogastric animals, limited information is available on its presence and distribution in cattle. This study aimed to investigate the distribution and localization patterns of cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) and transient receptor potential vanilloid type 1 (TRPV1) in the bovine small intestine. The study included immunohistochemical analysis of intestinal tissue samples from Polish Holstein-Friesian breed bulls. Gene expression levels of CNR1, CNR2, and TRPV1 genes, encoding CB1R, CB2R, and TRPV1, respectively, were quantified using qPCR analysis. The results showed that all three receptors were expressed in the bovine small intestine, with TRPV1 exhibiting a significant upregulation in the jejunum compared to the duodenum and ileum. Immunoreactivity for CB1R and CB2R was predominantly observed in neurons of the enteric plexuses, while TRPV1 immunolabeling was detected in both enteric neurons and duodenal Brunner’s glands. These findings may establish an anatomical foundation for further investigations, lending support to the potential therapeutic efficacy of cannabinoid receptor agonists in alleviating gastrointestinal motility disorders associated with bovine enteropathies and optimizing milk production in dairy cattle.
Hippocampus and jejunum biochemical parameters related to physiological ageing of neurons in rats fed diets with copper nanoparticles and different fiber types
Authors: Krauze Magdalena , Juśkiewicz Jerzy , Fotschki Bartosz , Pinkosz Michalina , Ognik Katarzyna 
Published: February 2024

Abstract
One of the more important factors responsible for synaptic dysfunction of neurons is a neurological ageing. It is a natural consequence of occurrence of biochemical pathways in cells, promoting oxidation processes, an increase in the amount of free oxygen radicals that damage DNA, disorders in calcium ion homeostasis, interactions between lipids of cell membranes, formation of neurofibrillary tangles and deposition of toxic protein deposits. Diet modifications can delay neurometabolism disorders that occur as a result of aging, as well as limit the development of neurodegenerative diseases. The aim of this study on rats was to verify the hypothesis regarding the effect of dietary addition of copper nanoparticles (CuNPs; instead of standard CuCO3) in combination with various dietary fibers on changes in hippocampus and jejunum biochemical parameters related to metabolic disorders appearing with neurological ageing in rats. Male rats were fed a control diet with containing fiber α-cellulose and a standard or enhanced content of Cu provided as CuCO3 (6.5 or 13 mg/kg diet). The diets of other groups were deprived of CuCO3 and the animals were fed diets supplemented with two CuNPs aforementioned doses, and additionally combined with four different types of dietary fiber: α-cellulose (control fiber), pectin, inulin or psyllium (Plantago psyllium). The addition of dietary CuNPs increased the level of acetylcholinesterase (AChE) and decreased the levels of Tau protein, glycosylated AChE (GAChE) and Ca/calmodulin dependent protein kinase II alpha (CAMK2α) in the examined organs. To sum up, both applied doses of CuNPs, 6.5 mg and 13 mg per kg of a diet, can beneficially modulate some important parameters describing metabolic and neurodevelopmental status in the hippocampal and small intestinal tissue of rats. With regard to the fiber type added to rats’ diet, the Plantago psyllium fiber strengthened the mentioned effects of copper nanoparticles. The observed effects should be confirmed in a model study of neurodegeneration.
IDENTIFIKASI SLUM AREA DI KOTA BANDA ACEH : STUDI KASUS DI GAMPONG JAWA KECAMATAN KUTARAJA
Authors: Aqsar Muharrir Al , Desfandi Mirza 
Published: February 2024

ABSTRACTThis study reveals the characteristics of slums in Gampong Java, including facilities and infrastructure, physical, social, economic, and hazards. This research uses qualitative methods with data collection techniques through observation, in-depth interviews, and documentation. Samples were taken by Cluster Random Sampling technique from the population of Gampong Java. This research focused on Tengku Muda Hamlet or the 5th alley which is a slum. Descriptive analysis is performed on the collected data. Factors that lead to slums include lack of basic services, limited access to sanitation facilities, uninhabitable houses, high building density, and illegal construction. This research is expected to provide a better understanding of the slum area in Gampong Java and provide important input in efforts to overcome the slum area in Banda Aceh City.Keywords: Slum, characteristics, Gampong Java, Banda Aceh ABSTRAKPenelitian ini mengungkapkan ciri-ciri permukiman kumuh di Gampong Jawa, termasuk sarana dan prasarana, fisik, sosial, ekonomi, dan bahaya. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan data melalui observasi, wawancara mendalam, dan dokumentasi. Sampel diambil dengan teknik Cluster Random Sampling dari populasi Masyarakat Gampong Jawa. Penelitian ini difokuskan pada Dusun Tengku Muda atau lorong ke-5 yang merupakan kawasan kumuh. Analisis deskriptif dilakukan terhadap data yang terkumpul. Faktor-faktor yang menyebabkan kawasan kumuh antara lain kurangnya pelayanan dasar, akses terbatas terhadap fasilitas sanitasi, rumah tidak layak huni, kepadatan bangunan yang tinggi, dan pembangunan ilegal. Penelitian ini diharapkan dapat memberikan pemahaman yang lebih baik tentang slum area di Gampong Jawa dan memberikan masukan penting dalam upaya penanggulangan slum area di Kota Banda Aceh .Kata kunci: Kawasan kumuh, karakteristik, Gampong Jawa, Banda Aceh
Perbandingan Kerja Binomial GLMM <i>Tree </i>dan BIMM <i>Forest </i>untuk Memodelkan Status Bekerja Penduduk
Authors: Sirodj Dwi Agustin Nuriani , Notodiputro Khairil Anwar , Sartono Bagus 
Published: February 2024

Model prediksi berbasis pada pohon keputusan saat ini banyak dikembangkan di berbagai bidang. Pengembangan metode yang dilakukan diantaranya memasukkan pengaruh acak ke dalam model. Generalized linier mixed model (GLMM) Tree menjadi salah satu model yang dapat mengakomodasi adanya pengaruh acak dan dilakukan dengan metode partisi rekursif hanya saja waktu komputasi yang dibutuhkan relatif lebih lama. Selanjutnya metode alternatif lainnya adalah Binary Mixed Model (BiMM) Forest yang menggabungkan prinsip kerja Bayesian GLMM dan Random Forest. Dari kedua metode yang akan digunakan maka permasalahan yang dihadapi adalah bagaimana kinerja dari metode GLMM Tree dan BiMM Forest jika diterapkan untuk klasifikasi status bekerja penduduk di Kabupaten Bogor dan Kabupaten Pangandaran. Dari hasil analisis tampak bahwa metode BiMM Forest memiliki kinerja yang lebih baik di bandingkan dengan GLMM Tree untuk kedua daerah. Selain itu ditunjukkan pula bahwa peubah yang penting dalam proses klasifikasi status bekerja penduduk di Kabupaten Bogor dan Kabupaten Pangandaran adalah peubah terkait aspek pendidikan, sosial, dan ekonomi.
Analisis Program Muhadharah Usbuiyah terhadap Penanaman Karakter Percaya Diri Santriwati di PP. Riyadul Fattah Al-Barqi Lampung
Authors: Effendi Fikriansyah , Erika Kurnia Sari  , Retno Wulang Ningsih  
Published: February 2024

Pendidikan karakter merupakan hal penting yang harus ditanamkan pada santri. Muhadharah merupakan salah satu kegiatan yang dapat menanamkan pendidikan karakter. Maka dari itu, Pondok Pesantren Riyadul Fattah AL-Barqi Desa Purwodadi Kecamatan Gisting Kabupaten Tanggamus mempunyai cara untuk menanamkan pendidikan karakter melalui kegiatan muhadharah. Tujuan penelitian ini adalah: Untuk mengetahui penanaman karakter santriwati dalam pembiasaan Muhadharah Usbuiyah di Pondok Pesantren Riyadul Fattah Al- Barqi Desa Purwodadi Kecamatan Gisting Kabupaten Tanggamus. Metode penelitian ini menggunakan pendekatan kualitatif-Deskriptif. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data model Matthew B. Milles yang meliputi: kondensasi data, penyajian data, serta verifikasi dan kesimpulan. Keabsahan data mengguanakan triangulasi sumber dan teknik.
Penelitian ini memperoleh kesimpulan penanaman nilai pendidikan karakter percaya diri dalam kegiatan muhadharah di Pondok Pesantren Riyadul Fattah Al-Barqi Desa Purwodadi Kecamatan Gisting Kabupaten Tanggamus yaitu para santriwati terlihat percaya diri dalam berpidato
Effect of oral vitamin E supplementation on lipid profile in diabetes mellitus: evidence based case report
Authors: Wulandari Indah Sri , Sutanto Krisadelfa 
Published: February 2024

Introduction: Diabetes mellitus, a prominent non-communicable disease, presents as a chronic condition associated with various complications, including heart disease, nerve damage, chronic kidney disease, and dyslipidemia. A pivotal abnormality in diabetic dyslipidemia is insulin resistance, which stimulates the production of Hepatic VLDL1 (very-low-density lipoprotein 1). The resulting overproduction of VLDL1 is metabolically linked to an abundance of small, dense LDL (low-density lipoprotein) particles and a reduction in large, cholesterol-rich HDL2 (high-density lipoprotein). Conversely, vitamin E, known for its antioxidant and anti-inflammatory properties, acts as a remover of peroxyl radicals, preventing lipid oxidation and safeguarding polyunsaturated fatty acids (PUFA) within cells and plasma lipoproteins.
Method: This study investigates the impact of oral vitamin E supplementation on the lipid profile in diabetic patients. Employing advanced search techniques on databases like PubMed, Cochrane Library, and Google Scholar, we conducted a comprehensive literature search using MeSH terms, advanced search methods, and specific eligibility criteria. The results yielded one systematic review with a meta-analysis and two randomized controlled trials (RCTs) that met the predefined PICO and eligibility criteria.
Results: The systematic review and meta-analysis, along with one RCT, reported no significant reduction in lipid profiles with oral vitamin E supplementation in diabetic patients. In contrast, the other RCT observed an improvement in lipid profiles among diabetic patients receiving oral vitamin E supplementation.
Conclusion: Supplementing with oral vitamin E does not enhance the lipid profile of individuals with diabetes mellitus.
Effect of omega-3 supplementation on osteoarthritis: An evidence-based case report
Authors: Ferdi Jessica , Diana Sunardi  
Published: February 2024

Background: Osteoarthritis is marked by mild inflammation, causing cartilage damage that leads to bone remodelling and potentially reduces the quality of life. Omega-3 has anti-inflammatory properties, which can help mitigate cartilage damage.
Objective: This research aims to determine the role of omega-3 in relieving pain in patients with osteoarthritis.
Methods: A literature search was conducted using advanced searching on three large databases: PubMed, Cochrane, and Scopus. The search used Mesh terms according to the criteria. After assessing the relevance and suitability of the literature, two articles were selected and critically evaluated based on Oxford Center for Evidence-Based Medicine.
Results: Two systematic review-meta-analyses that meet the PICO and eligibility criteria were found. One of the literature sources does not demonstrate the effect of omega-3 supplementation on joint pain, while the other literature source shows the beneficial effects of omega-3 in reducing joint pain in osteoarthritis.
Conclusion: Omega-3 supplementation can alleviate joint pain in individuals with osteoarthritis. Providing omega-3 may be worth considering.
Nutrient-rich food index 9.3 score and food choice values among female online food delivery users during COVID-19 pandemic
Authors: Palupi Nadya Suci , Chandra Dian Novita , Februhartanty Judhiastuty , Khusun Helda , Hanisa Nisrina , Dewi Dian Kusuma 
Published: February 2024

Background: The COVID-19 pandemic has transformed eating habits, leading to an increased reliance on online food delivery. It's crucial to comprehend the diet quality and food choices among female users during this period.
Objective: This study aims to explore the association between diet quality score and the food choice motives among female online food delivery users during the COVID-19 pandemic
Methods: This online cross-sectional study involved surveying 405 female users recruited through consecutive sampling. The Food Choice Values Questionnaire (FCVQ) was utilized to understand their food choices, while nutrient intake and diet quality were assessed using the Nutrient-Rich Food 9.3 Index Score (NRF 9.3). Subsequently, the collected data underwent both univariate and multivariate analyses. Potential biases might arise due to time constraints during the pandemic and reliance on self-reported online data. Moreover, the method used to measure nutrient intake might not be ideal for this demographic, lacking tailored tests. Nonetheless, it’s important to highlight that the survey underwent prior validation among Indonesian adults, affirming its broad applicability.
Results: Female users showed low average NRF 9.3 scores (241.67), indicating poor diet quality. Their prioritized food choice motives were also low. Significant associations surfaced between NRF 9.3 scores and food choice motives—tradition (p<0.01, r: 0.229), comfort (p<0.01, r: 0.223), organic (p<0.01, r: 0.231), safety (p<0.001, r: 0.162), weight control/health (p<0.01, r: 0.171), and income (p<0.05).
Conclusion: The NRF 9.3 score is likely to increase when there are higher scores for tradition, comfort, and organic factors, and when income exceeds the minimum regional wage.
A autoavaliação do atendimento em saúde pela população transgênera
Authors: Santos Esther Lucia Martins Marinho dos , Bellemo Ana Isabel Sobral 
Published: February 2024

Objetivo: Entender e conhecer a autopercepção do atendimento em saúde pela população transgênero, no intuito de refletir ações prestadas pelos profissionais de saúde. Métodos: Estudo quantitativo transversal realizado através de um formulário criado pelas autoras, disponibilizado na plataforma do Google Forms e que aceitaram a sua participação através da assinatura do Termo de Consentimento Livre e Esclarecido (TCLE) com a utilização de gráficos gerados pelo GraphPad Prism 10.5. Resultados: Participaram 34 indivíduos transgêneros, na maioria moradores do Estado de São Paulo, somente 70,5% já começaram o Processo Transexualizador, porém somente 33,3% referem ter recebido orientações da equipe. 78,1% afirmam ainda sofre com preconceitos ligados ao atendimento de saúde. Conclusão: Mesmo assegurado por leis federais, o indivíduo transexual enfrenta barreiras em seu acesso ao atendimento em saúde mostrando o desrespeito na sua essência. O estudo traz a necessidade de estabelecer uma maior educação em saúde para a equipe multiprofissional e a conscientização da sociedade no respeito a população transexual. A recepção e o acolhimento dessa população no sistema de saúde vão além da humanização, da ética e do respeito aos direitos humanos, tratando-se de uma mudança cultural.