bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions that help to improve spontaneous adverse drug reaction reporting by patients: a protocol of a scoping review
Authors: Martinelli Romina P , Papazian M Gabriela 
Published: February 2024

AbstractWhen a new medical product is released to the market, a continuous pharmacovigilance process is initiated to guarantee patient safety by collecting and analyzing adverse drug reaction (ADR) reports. These ADRs are noxious and unintended responses to a medicine and are collected and analyzed in databases like EudraVigilance to determine safety profiles of the products and signal detection. The spontaneous reporting of suspected ADR could be performed by both health care workers and patients/consumers. However, the under-reporting is well known. Different initiatives have been developed to encourage reporting by health professionals, however, further work is required to support patients in taking a more active role in reporting adverse drug reactions. In this context, we will conduct a Scoping Review of the literature to inquire about what is known about actions or strategies to improve pharmacovigilance engagement by patients. We will conduct searches in MEDLINE/PubMed, Scielo, Latindex, DOAJ, CINAHL, LILACS, IAM, IMEMR, IMSEAR, WPRO, and Cochrane Library databases. Two reviewers will screen all identified records for relevance. Conflicts between reviewers will be solved by consensus. We will chart the data using data-charting forms. Findings will be reported according to PRISMA for Scoping Reviews (PRISMA-ScR). No quality assessment will be performed.
Integrative genomics sheds light on the immunobiology of tuberculosis in cattle
Authors: O’Grady John F. , McHugo Gillian P. , Ward James A. , Hall Thomas J. , Faherty O’Donnell Sarah L. , Correia Carolina N. , Browne John A. , McDonald Michael , Gormley Eamonn , Riggio Valentina , Prendergast James G. D. , Clark Emily L. , Pausch Hubert , Meade Kieran G. , Gormley Isobel C. , Gordon Stephen V. , MacHugh David E. 
Published: February 2024

AbstractMycobacterium boviscauses bovine tuberculosis (bTB), an infectious disease of cattle that poses a zoonotic threat to humans. Research has shown that bTB susceptibility is a heritable trait, and that the peripheral blood (PB) transcriptome is perturbed during bTB disease. Hitherto, no study has integrated PB transcriptomic, genomic and GWAS data to study bTB disease, and little is known about the genomic architecture underpinning the PB transcriptional response toM. bovisinfection. Here, we perform transcriptome profiling of PB from 63 control and 60 confirmedM. bovisinfected animals and detect 2,592 differently expressed genes that perturb multiple immune response pathways. Leveraging imputed genome-wide SNP data, we characterise thousands ofcis- andtrans-expression quantitative trait loci (eQTLs) and show that the PB transcriptome is substantially impacted by intrapopulation genomic variation. We integrate our gene expression data with summary statistics from multiple GWAS data sets for bTB susceptibility and perform the first transcriptome-wide association study (TWAS) in the context of tuberculosis disease. From this TWAS, we identify 136 functionally relevant genes (includingRGS10,GBP4,TREML2, andRELT) and provide important new omics data for understanding the host response to mycobacterial infections that cause tuberculosis in mammals.
Identification of Thioredoxin1 interacting proteins in neuronal cytoskeletal organization during autophagy
Authors: Islam Md Imamul , Sultana Shakila , Padmanabhan Nirmala , Rashid Mahmud-ur , Siddiqui Tabrez , Coombs Kevin , Vitiello Peter F. , Karimi-Abdolrezaee Soheila , Eftekharpour Eftekhar 
Published: February 2024

AbstractThioredoxin1 (Trx1) is a major cytoplasmic thiol oxidoreductase protein involved in redox signaling. This function is rendered by a rapid electron transfer reaction during which Trx1 reduces its substrate and itself becomes oxidized. In this reaction, Trx1 forms a transient disulfide bond with the substrate which is unstable and therefore identification of Trx1 substrates is technically challenging. This process maintains the cellular proteins in a balanced redox state and ensures cellular homeostasis. Trx1 levels are reduced in some neurodegenerative diseases; therefore, understanding the interactions between Trx1 and its substrates in neurons could have significant therapeutic implications. We utilized a transgenic mouse model expressing a Flag-tagged mutant form of Trx1 that can form stable disulfide bonds with its substrates allowing identification of the Trx1 interacting proteins. The involvement of Trx1 has been suggested in autophagy, we aimed to investigate Trx1 substrate after pharmacologic induction of autophagy in primary hippocampal neurons. Treatment of primary neurons by rapamycin, a standard autophagy inducer, caused significant reduction of neurite outgrowth and alterations in the cytoskeleton. Through immunoprecipitation and mass spectrometry, we have identified 77 Trx1 interacting proteins which were associated with a wide range of cellular functions including a major impact on cytoskeletal organization. The results were confirmed in Trx1 knocked-down cells and in nucleofected primary neurons. Our study suggests a novel role for Trx1 in regulation of neuronal cytoskeleton organization, marking the first investigation of Trx1-interacting proteins in primary neurons and confirming the multifaceted role of Trx1 in physiological and pathological states.
CapP mediates the structural formation of biofilm-specific pili in the opportunistic human pathogenBacillus cereus
Authors: Álvarez-Mena Ana , Shukkoor Muhammed Bilal Abdul , Caro-Astorga Joaquín , Berbon Melanie , Antequera-Gómez María Luisa , Grélard Axelle , Kauffmann Brice , Morvan Estelle , de Vicente Antonio , Habenstein Birgit , Loquet Antoine , Romero Diego 
Published: February 2024

SUMMARYPolymeric proteinaceous filaments are structural scaffolds that diversify the functionality of the bacterial extracellular matrix. Here, we report a previously uncharacterized bacterial factor calledbc1280that is exclusive toB. cereusgroup and indispensable for the establishment of a biofilm lifestyle. We propose that BC1280 is an essential chaperone for the assembly of the filamentous platform that tightly controls the polymerization of heteropili containing CalY and TasA as major subunits in a concentration-dependent manner. Additionally, BC1280 modulates the expression of EPS via an uncharacterized pathway that is activated by a protease and an ECF-type sigma factor. The pilus biogenesis system described in this work highlights the complexity of extracellular matrix assembly inB. cereusand introduces a singular three-part structuration mechanism during biofilm formation and maturation.Graphical abstractDuring the process of biofilm formation inB. cereus, TasA, CapP, and CalY serve as the main components, in addition to other factors, ensuring that the extracellular matrix correctly assembles. The three proteins are produced and processed by the signal peptidase SipW and subsequently secreted through the Sec pathway in an unfolded conformation. At early biofilm formation stages, CapP is initially present at low levels, associates with the cell wall and is secreted into the ECM where it interacts with unfolded subunits of CalY, facilitating CalY folding and initiating fibril growth. CalY serves as a nucleator for incorporating TasA subunits into the pilus, forming TasA-CalY heteropolymers. Once the ECM scaffold is established, CapP levels increase, forming stable complexes with CalY that prevent its folding and arrest filament growth.
Unveiling the coopetition pathway: the stakeholder influence in the specialty coffee market
Authors: Duarte Rodrigo Natal , Guimarães Elisa Reis , do Valle Maurício Ribeiro , Galina Simone Vasconcelos Ribeiro 
Published: February 2024

PurposeThis study aimed to understand coopetition in the context of Brazilian specialty coffee grower Small and medium enterprises (SMEs), based on the need to differentiate the beans in and outside the farm level, taking into account the stakeholders’ influence.Design/methodology/approachIn this study twenty semistructured interviews were carried out with coffee growers and managers of cooperatives, associations and supporting institutions involving two Brazilian coffee geographical indications. Data were analyzed using a mixed grid composed of qualitative, semantic and categorical factors.FindingsStrategic moves undertaken by coffee growers and stakeholders have shaped the pathway of coopetition among coffee growers, as determinants to frame it as a deliberate or emergent pattern (intentional or unplanned, respectively). Our findings provide evidence that coopetition development among firms is deliberate when influenced by firms’ or stakeholders’ cooperative moves and emergent when influenced by firms’ or stakeholders’ competitive moves.Originality/valueAlthough the firm/stakeholder relationship is often approached as a joint wealth creation effort, stakes are not always fairly distributed, so one of the parties may be negatively affected, with consequences for the development of coopetition. Underpinned by a stakeholder-oriented resource-based theoretical lens, this investigation of the development patterns of coopetition linked to the strategic actions undertaken by firms and stakeholders has resonance on competitive advantages.
An assessment of critical success factors in information security implementation in organizations in Ghana
Authors: Nterful Joshua , Adam Ibrahim Osman , Alhassan Muftawu Dzang , Abdul-Salam Abdallah , Gbambegu Umar Abubakar 
Published: February 2024

Purpose
This paper aims to identify the critical success factors in improving information security in Ghanaian firms.

Design/methodology/approach
Through an exploratory study of both public and private Ghanaian organizations. The study relied on a research model based on the technology–organization–environment (TOE) framework and a survey instrument to collect data from 525 employees. The data was analyzed using partial least squares-structural equation modeling (PLS-SEM).

Findings
The findings confirm the role of the technological, organizational and environmental contexts as significant determinants in the implementation of information security in Ghanaian organizations. Results from PLS-SEM analysis demonstrated a positive correlation between the technology component of information security initiative, organization’s internal efforts toward its acceptance and a successful implementation of information security in Ghanaian firms. Top management support and fund allocation among others will result in positive information security initiatives and positive attitudes toward securing the organization’s information assets.

Research limitations/implications
The authors discussed the implications of the authors’ findings for research, practice and policy.

Social implications
The results of this study will be useful for both governmental and non-governmental organizations in terms of best practices for increasing information security. Results from this study will aid organizations in developing countries to better understand their information security needs and identify the necessary procedures to address them.

Originality/value
This study contributes to filling the knowledge gap in organizational information security research and the TOE framework. Despite the TOE framework being one of the most influential theories in contemporary research of information system domains in an organizational context, there is not enough research linking the domains of information security and the TOE model.
Sustainability teaching in higher education: assessing arts and design faculty perceptions and attitudes
Authors: Kang Mihyun , Cholakis-Kolysko Katherine , Dehghan Negar 
Published: February 2024

Purpose
The purpose of this study is to examine the perceptions and attitudes of arts and design faculty on teaching sustainability in higher education institutions in the USA.

Design/methodology/approach
Arts and design faculty from nine universities in the USA were approached for the study, using both closed and open-ended questions in a survey instrument. Descriptive statistics and content analysis were used to analyze the collected data.

Findings
Results related to arts and design faculty’s perception of sustainability showed high confidence in teaching sustainability but lower confidence in inspiring students to take action on sustainability issues. Faculty also perceived time, resources, knowledge and support as barriers to the integration of the topic into the curriculum. This study revealed that the faculty’s attitude toward sustainability demonstrated their recognition that sustainability should be at the core of their discipline and that they support its integration into courses.

Research limitations/implications
This study is limited to arts and design faculty in higher education institutions in the USA. The results may not be generalizable to other fields or locations. In addition, the use of self-reported data may be subject to bias.

Practical implications
The findings of this study can inform the development of curriculum and pedagogy in arts and design sustainability education. It can also guide institutions in addressing the challenges and barriers related to incorporating sustainability into their curriculum.

Social implications
Prioritizing sustainability education is crucial in addressing global climate change and related issues. Art and design educators’ perspectives on teaching sustainability can contribute to constructing a sustainable future for everyone.

Originality/value
This study provides insight into the perception and attitude of sustainability among arts and design faculty in higher education in the USA and highlights areas for improvement such as training and resources to better integrate sustainability into the curriculum.
Entrepreneurship in times of economic stress: unraveling the U-shaped relationship between the internality of causal attributions and growth
Authors: Monteiro Guilherme Fowler A. , Artes Rinaldo 
Published: February 2024

PurposeThis paper examines the relationship between entrepreneurs' internality of causal attributions and firm growth during an economic crisis. We propose a U-shaped relationship between the two variables, arguing that the highest-growth entrepreneurs are those with either the highest or lowest levels of internal attribution (IA) during such periods.Design/methodology/approachTo test our hypothesis, we analyze a database of 804 interviews with entrepreneurs in Brazil during a period of economic stress. Due to the existence of endogeneity, we estimate a model of simultaneous equations in two stages.FindingsWe find evidence of a U-shaped relationship. This means that during economic stress, the fastest-growing entrepreneurs are those who rely more on their own effort (high IA) and those who attribute their success to the economic crisis (low IA).Practical implicationsTailoring interventions based on attribution patterns and recognizing the U-shaped relationship ensures effective support during economic stress. Entrepreneurial support programs should align with internality levels, emphasizing external awareness or skill development accordingly. Policymakers should take attributions into account when promoting financial resilience. Entrepreneurs would benefit from awareness programs on attributions for reflective decision-making. Ecosystems should foster collaboration by recognizing diverse attributions, enhancing a collective understanding of entrepreneurial responses in crises.Originality/valueOur results have important implications for understanding the role of entrepreneurs in economic crises. Our results are relevant because they challenge the usual claim that entrepreneurs with high IA are the ones who perform better in situations where external economic conditions are adverse.
The role of digital literacy and digital data security awareness in online privacy concerns: a multi-group analysis with gender
Authors: Saritepeci Mustafa , Yildiz Durak Hatice , Özüdoğru Gül , Atman Uslu Nilüfer 
Published: February 2024

PurposeOnline privacy pertains to an individual’s capacity to regulate and oversee the gathering and distribution of online information. Conversely, online privacy concern (OPC) pertains to the protection of personal information, along with the worries or convictions concerning potential risks and unfavorable outcomes associated with its collection, utilization and distribution. With a holistic approach to these relationships, this study aims to model the relationships between digital literacy (DL), digital data security awareness (DDSA) and OPC and how these relationships vary by gender.Design/methodology/approachThe participants of this study are 2,835 university students. Data collection tools in the study consist of personal information form and three different scales. Partial least squares (PLS), structural equation modeling (SEM) and multi-group analysis (MGA) were used to test the framework determined in the context of the research purpose and to validate the proposed hypotheses.FindingsDL has a direct and positive effect on digital data security awareness (DDSA), and DDSA has a positive effect on OPC. According to the MGA results, the hypothesis put forward in both male and female sub-samples was supported. The effect of DDSA on OPC is higher for males.Originality/valueThis study highlights the positive role of DL and perception of data security on OPC. In addition, MGA findings by gender reveal some differences between men and women.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-03-2023-0122
Building a community of practice through a doctoral research group
Authors: Heron Marion , Dippold Doris , Gravett Karen , Ahmad Adeeba , Aljabri Samaher , Abuorabi Al-Adwan Razan , Ghosh Priyanki , Kabooha Raniah , Makram Mohammad , Mousawa Dina , Mudhaffer Ayesha , Ucar Longford Beyza , Wang Lingyu , Zhou Junyi , Zhu Fengmei 
Published: February 2024

Purpose
The purpose of this paper is to highlight the role an intentional and cohesive research group for doctoral researchers and supervisors can play in surfacing and de-mystifying many of the implicit doctoral literacy practices involved in doctoral study.

Design/methodology/approach
This participatory, collaborative project, involving 11 doctoral researchers and three supervisors, was conducted in two stages. In the first stage, doctoral researchers and supervisors engaged in a discussion which resulted in a shared concept map. The concept map was then used as a prompt for stimulated recall interviews in which the participants reflected on the connections and peer learning afforded by the research group.

Findings
Drawing on ideas from Communities of Practice theory, the data revealed that the research group, including both supervisors and doctoral students, developed knowledge, relational connections and an awareness of a range of doctoral literacies.

Practical implications
This paper makes suggestions for how those in doctoral education can develop and embed research groups into institutional practices.

Originality/value
This study demonstrates the significant role a research group which is structured, intentional and guided plays in supervisors’ and doctoral students’ development of doctoral literacies and the fundamental intellectual and relational connections afforded by participating in such communities.
Digital Skills Mobilization within Incumbent Organizations: The Agentic Role of Digital Champions
Authors: D'angelo Stefano , Ghezzi Antonio , Cavallo Angelo 
Published: February 2024

AbstractIn a world increasingly influenced by digital technologies, incumbent organizations are urged to equip their employees with digital skills to unlock the transformative power of digitalization for their strategy and business model. Yet, extant research lacks guidance on how to mobilize and implement effective initiatives to develop digital skills in incumbents. Therefore, through an in‐depth case study of a utility company, this paper explores how an incumbent can mobilize its digital skills to embrace digital transformation. Based on the process perspective of resource mobilization, we shed light on the mechanisms for searching, accessing and transferring digital skills, namely: (i) unearthing dormant digital skills; (ii) awakening digital skill‐holders; and (iii) disseminating digital skills. In the investigation of these mechanisms, we uncover the agentic role of digital champions, who become an organizational capability for mobilizing digital skills in incumbents. We also document how digital technologies, as operant resources, can transversally support all stages of the mobilization of digital skills aimed at developing and leveraging digital skills in incumbents. In doing so, we explore the role of digitalization, both as the content of resource mobilization, in terms of digital skills, and as the means through which mobilization is enacted, in terms of digital assets and initiatives. Based on the findings of this study, we contribute to knowledge at the interface between digitalization and resource mobilization in the broader context of digital transformation.
The effect of the anti‐coagulant EDTA on the deposition and adhesion of whole blood deposits on non‐porous substrates
Authors: Hughes Deborah A. , van Oorschot Roland A. H. , Szkuta Bianca , Conlan Xavier A. 
Published: February 2024

AbstractAn investigation into whether the addition of a commonly used anti‐coagulant agent like ethylenediaminetetraacetic acid (EDTA) has an impact on the adhesion potential of blood to non‐porous substrates was conducted. Two non‐porous substrates (aluminum and polypropylene) exhibiting six different surface roughness categories (R1–R6) were used as test substrates upon which either whole blood or blood treated with EDTA was deposited. Samples were exposed to different drying periods (24 hours, 48 hours, and 1 week) before undergoing a tapping agitation experiment in order to evaluate the adhesion to the surface. Clear differences in adhesion potential were observed between whole blood and blood treated with EDTA. Blood treated with EDTA displayed a stronger adhesion strength to aluminum after a drying time of 24 h pre‐agitation, while whole blood presented with a stronger adhesion strength at the drying time of 48 h and 1 week. Both EDTA‐treated and EDTA‐untreated blood was shown to dislodge less easily on polypropylene with the only difference observed on smooth surfaces (0.51–1.50 μm surface roughness). Thus, when conducting transfer studies using smooth hydrophobic substrates like polypropylene or considering the likelihood of transfer given specific case scenarios, differences in adhesion strength of blood due to hydrophobic substrate characteristics and a decreased surface area need to be considered. Overall, whole blood displayed a better adhesion strength to aluminum, emphasizing that indirect transfer probability experiments using EDTA blood on substrates like aluminum should take an increased dislodgment tendency into account in their transfer estimations.