bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of proteomics technology to thrombosis research: the identification of potential therapeutic targets in cardiovascular disease
Authors: Howes Joanna-Marie , Keen Jeff N , Findlay John BC , Carter Angela M 
Published: September 2008

Thrombus formation underpins the development of cardiovascular diseases, including acute coronary syndromes and ischaemic stroke. A number of wellcharacterised cardiovascular risk factors which contribute to the development of the majority of cardiovascular events have been identified, including dyslipidaemia, hypertension and diabetes. Individuals with type 2 diabetes mellitus (T2DM) have a 3- to 5-fold increased risk for development of cardiovascular disease (CVD). They may have a cluster of haemostatic abnormalities, including elevated levels of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, which contribute to acute thrombotic events. It is clear that additional unidentified risk factors contribute to the pathogenesis of cardiovascular events, and so the search for novel biomarkers and effectors, particularly in individuals with T2DM, remains a major challenge of cardiovascular medicine. Plasma and cellular proteins which contribute to thrombus formation have the potential to confer a prothrombotic state and represent a link between genotype, environment and disease phenotype. The comprehensive analysis of these proteins is now increasingly facilitated through the continued development of proteomic technologies which provide multifaceted approaches to the identification of novel biomarkers and/or effectors of thrombus formation and on which future anticoagulant and thrombolytic therapies may be based. This review provides an overview of current proteomic technologies. It focuses on the recent studies in which these technologies have been applied in the search for novel proteins that may confer increased risk of acute cardiovascular diseases and therefore that may influence disease progression and therapy.
Comparing measures of cognitive bias relating to eating behaviour
Authors: Pothos Emmanuel M. , Calitri Raff , Tapper Katy , Brunstrom Jeffrey M. , Rogers Peter J. 
Published: September 2008

AbstractConsumption of and/or abstinence from substances with a high reward value (e.g. heroin, marijuana, alcohol, nicotine, certain foods) are associated with cognitive biases for information related to the substance. Such cognitive biases are important since they may contribute to difficulties in controlling intake of the substance. We examine cognitive biases for stimuli related to food. For the first time, we concurrently employ and compare five conceptually distinct measures of cognitive bias (dot probe, emotional Stroop, recognition, EAST, explicit attitudes). Contrary to expectations from current theory, the relation between the cognitive measures was weak and evident only in certain subsets of the population sample, as defined by gender and emotional‐, restrained‐ and external‐eating characteristics of our participants. We discuss some methodological implications of our findings. Copyright © 2008 John Wiley & Sons, Ltd.
Effects of mugshot commitment on lineup performance in young and older adults
Authors: Goodsell Charles A. , Neuschatz Jeffrey S. , Gronlund Scott D. 
Published: September 2008

AbstractTwo experiments assessed the effects of mugshot commitment on the ability to make a subsequent lineup identification. Young (17–37 years) and older (55–87 years) participants viewed a crime video featuring a younger (20 years) or older (64 years) culprit. Some participants viewed a 50‐photograph culprit‐absent mugbook. Following a 1‐week delay, participants returned to view a culprit present lineup. In Experiment 1, mugbook choosers tended to select their prior selection in the lineup and mugbook nonchoosers tended to reject the lineup. In Experiment 2, mugshot choosers rejected a lineup that did not contain their prior selection. Commitment to a prior selection and commitment to a selection strategy were the cause of the majority of lineup errors. As previously reported, mugshot exposure harms subsequent lineup identification, and this appears to be primarily the result of commitment effects. Copyright © 2008 John Wiley & Sons, Ltd.
Illustrating computational solvent screening: Prediction of standard Gibbs energies of reaction in solution
Authors: Peters Martina , Greiner Lasse , Leonhard Kai 
Published: September 2008

AbstractPrediction of thermodynamic properties of new compounds or mixtures is industrially important, especially when processes are established or alternatives for existing processes are evaluated. Of particular importance is the equilibrium constant, derived from the standard Gibbs energy of reaction in solution. Up to date, experimental determination is challenging, mirrored by a lack of data available. A straightforward computational way for the prediction using quantum mechanics and statistical thermodynamics is presented. The use of three standard quantum chemical methods for the determination of the ground state energies enables a comparison in terms of accuracy and computational cost. The results show that the two most laborious methods coupled cluster with single and double excitations and perturbative triple excitations and MP2 lead to comparable accuracy, whereas the fastest method density functional theory leads to considerable deviations. Hence, the method of choice for the prediction of standard Gibbs energies of reaction in solution with good accuracy at medium computational cost is MP2 combined with conductor‐like screening model for real solvents COSMO‐RS. © 2008 American Institute of Chemical Engineers AIChE J, 2008
Ferrocenylimidazoline palladacycles as efficient catalysts for the aza‐Claisen rearrangement reaction of allylic imidates
Authors: Cui Xiuling , Ma Ji , Yang Dejian , Wu Junliang , Song Maoping , Wu Yangjie 
Published: September 2008

AbstractChloride‐bridged palladacycle dimers 1 have been evaluated as catalysts for the aza‐Claisen rearrangement of allylic imidates 2 to the corresponding allyl amides 3. Cyclopalladated complexes 1b–e bearing electron‐donating substituents on imidazoline ring were identified as being superior catalysts because excellent yields were obtained without using silver salts for activation. In addition, a correlation between substituents on the imidazoline ring and catalytic activity of palladacycles was established. The electron‐deficient ligands and good solubility of catalysts in the reaction solution increase the catalytic activity. Copyright © 2008 John Wiley & Sons, Ltd.
Styrene polymerization with nickel complexes/methylaluminoxane catalytic system
Authors: Li Yongfei , Gao Meili , Wu Qing 
Published: September 2008

AbstractPolymerization of styrene using β‐diketiminate nickel (II) bromide complexes CH{C(R)NAr}2NiBr (R = CH3, Ar = 2,6‐iPr2C6H3, 1; R = CH3, Ar = 2,6‐Me2C6H3, 2; R = CF3, Ar = 2,6‐iPr2C6H3, 3; R = CF3, Ar = 2,6‐Me2C6H3, 4) in the presence of methylaluminoxane was studied. Compound 3 is the most active styrene polymerization catalyst of all the nickel complexes tested. The activity of these catalysts increases with increases in steric bulk of the substituents on the aryl rings. The electronic nature of the ligand backbone also affects the activity. Weight‐average molecular weight of the prepared polystyrene ranges from 21 000 to 72 000, with polydispersity indexes of 1.95–2.78. The microstructure of the obtained products is atactic polystyrenes from NMR analyses. Copyright © 2008 John Wiley & Sons, Ltd.
Dodo birds, doctors and the evidence of evidence
Authors: Freddi Jason 
Published: September 2008

AbstractThis paper asks what is evidence‐based psychology and looks at the ways in which psychoanalysts have sought to engage with the challenges posed by this method of deciding best science. The paper examines the evidence for the evidence‐based method and looks at how psychoanalysts have attempted to shift the scientific debate from evidence‐based models to practice‐based, outcome driven models and, ultimately, to a patient‐therapy approach that seeks to marry best practice with a spirit of open‐minded assessment of alternatives. Copyright © 2008 John Wiley & Sons, Ltd.
Sexual boundary violations in residential drug‐free therapeutic community treatment
Authors: Gottdiener William H. 
Published: September 2008

AbstractThe purpose of this study was to investigate the phenomenon of sexual boundary violations in residential therapeutic community (TC) programs for substance abusers using secondary data analysis methods. One hundred and ninety‐seven participants who had been treated in TCs in New York City were interviewed 30 days post‐discharge. Sexual boundary violations were reported by approximately one‐quarter of the sample. Possible psychodynamic causes (e.g. enactments, group dynamics) of sexual boundary violations are discussed. Implications for research, theory, and for prevention of sexual boundary violations in TC programs are addressed. Copyright © 2008 John Wiley & Sons, Ltd.
On the use of archetypes as benchmarks
Authors: Porzio Giovanni C. , Ragozini Giancarlo , Vistocco Domenico 
Published: September 2008

AbstractBenchmarking plays a relevant role in performance analysis, and statistical methods can be fruitfully exploited for its aims. While clustering, regression, and frontier analysis may serve some benchmarking purposes, we propose to consider archetypal analysis as a suitable technique. Archetypes are extreme points that synthesize data and that, in our opinion, can be profitably used as benchmarks. That is, they may be viewed as key reference performers in the comparison process. We suggest a three‐step data driven benchmarking procedure, which enables users: (i) to identify some reference performers, (ii) to analyze their features, (iii) to compare observed performers with them. An exploratory point of view is preferred, and graphical devices are adopted throughout the procedure. Finally, our approach is presented by means of an illustrative example based onThe Timesleague table of the world top 200 universities. Copyright © 2008 John Wiley & Sons, Ltd.
Interleukin‐18 and gestosis: correlation with Helicobacter pylori seropositivity
Authors: Pugliese Agostino , Beltramo Tiziana , Todros Tullia , Cardaropoli Simona , Ponzetto Antonio 
Published: September 2008

AbstractThe aim of this brief communication was to determine the correlation between pre‐eclampsia (PE), Helicobacter pylori pathogenic strains seropositivity, and interleukin‐18 (IL‐18) levels. To this purpose 25 pre‐eclamptic women and 25 healthy parturient women of similar age were evaluated for:

IL‐18 levels, by ELISA
H. pylori seropositivity, by anti‐IgG ELISA
Anti‐Cag‐A antibodies using a commercial immunoblot assay.
We report similar values of IL‐18 in our pre‐eclamptic patients and in healthy parturient women (respectively 350 ± 150 vs. 399 ± 132 pg ml−1; p = 0.23). However the seropositivity for H. pylori was 84 and 32% (p < 0.001), and anti‐Cag‐A antibodies were present respectively in 80 and 28% of the two populations. On the basis of our data we hypothesize that H. pylori infection from Cag‐A strains can be involved in some cases of PE and that the microorganism could modulate IL‐18 release. In fact, differences on IL‐18 production have been described by different authors between pre‐eclamptic and healthy pregnant women, independently from infective pathology. Copyright © 2008 John Wiley & Sons, Ltd.
Improved inter‐modality image registration using normalized mutual information with coarse‐binned histograms
Authors: Nam Haewon , Renaut Rosemary A. , Chen Kewei , Guo Hongbin , Farin Gerald E. 
Published: September 2008

AbstractIn this paper we extend the method of inter‐modality image registration using the maximization of normalized mutual information (NMI) for the registration of [18F]‐2‐fluoro‐deoxy‐D‐glucose (FDG)‐positron emission tomography (PET) with T1‐weighted magnetic resonance (MR) volumes. We investigate the impact on the NMI maximization with respect to using coarse‐to‐fine grained B‐spline bases and to the number of bins required for the voxel intensity histograms of each volume. Our results demonstrate that the efficiency and accuracy of elastic, as well as rigid body, registration is improved both through the use of a reduced number of bins in the PET and MR histograms, and of a limited coarse‐to‐fine grain interpolation of the volume data. To determine the appropriate number of bins prior to registration, we consider the NMI between the two volumes, the mutual information content of the two volumes, as a function of the binning of each volume. Simulated data sets are used for validation and the registration improves that obtained with a standard approach based on the Statistical Parametric Mapping software. Copyright © 2008 John Wiley & Sons, Ltd.
Development and evaluation of a stabilized whole‐blood preparation as a process control material for screening of paroxysmal nocturnal hemoglobinuria by flow cytometry
Authors: Richards Stephen J. , Whitby Liam , Cullen Matthew J. , Dickinson Anita J. , Granger Viv , Reilly John T. , Hillmen Peter , Barnett David 
Published: September 2008

AbstractBackground:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder in which correct diagnosis is essential for effective patient management. Demonstration of deficiency of glycosylphosphatidylinositol (GPI)‐linked antigens from red cells and/or granulocytes by flow cytometry represents a highly specific diagnostic test for PNH. Currently, no external quality assessment (EQA) programme or reference material is available for whole‐blood PNH testing (red cells and leucocytes) by flow cytometry.Methods:In order to address this issue, we report the development of a stabilized whole‐blood PNH sample. We present the results of a detailed time course study by flow cytometry that demonstrates the stability of GPI‐linked antigen expression on granulocytes and red cells in a stabilized PNH peripheral blood sample, using a previously described method.Results:The PNH cells, as well as the coexisting normal red cell and granulocyte populations, remained stable for up to 120 days, both in terms of immunophenotypic and light scatter characteristics. Subsequent samples were used for a PNH EQA programme and issued to 92 laboratories worldwide.Conclusions:This study has highlighted that PNH testing by flow cytometry has significant problems with regard to false‐positive and ‐negative results. In addition, the variation in GPI‐linked antigen detection methods has highlighted the urgent need for standardized protocols. © 2008 Clinical Cytometry Society
Experience‐dependent refinement of the inhibitory axons projecting to the medial superior olive
Authors: Werthat Florian , Alexandrova Olga , Grothe Benedikt , Koch Ursula 
Published: September 2008

AbstractNeurons in the medial superior olive (MSO) analyze interaural time differences (ITDs) by comparing the arrival times of the two excitatory inputs from each ear using a coincidence detection mechanism. They also receive a prominent inhibitory, glycinergic projection from the ipsilateral medial nucleus of the trapezoid body (MNTB), which contributes to the fine‐tuning of ITD analysis. Here, we investigated developmental changes of the axonal arborisation pattern of single Microruby‐labeled MNTB neurons projecting to the MSO region. During the first 2 weeks after hearing onset, the axonal arborisation of MNTB neurons was significantly refined resulting in a narrowed projection area across the tonotopic axis of the MSO and a redistribution of the axonal endsegments to a mostly somatic location. Rearing the animals in omnidirectional noise prevented the structural changes of single MNTB projections. These results indicate that the functional elimination of inhibitory inputs on MSO neurons after hearing onset, as described previously, is paralleled by a structural, site‐specific refinement of the inputs and is dependent on the normal acoustic experience of the animal. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008
Extrinsic embryonic sensory stimulation alters multimodal behavior and cellular activation
Authors: Markham Rebecca G. , Shimizu Toru , Lickliter Robert 
Published: September 2008

AbstractEmbryonic vision is generated and maintained by spontaneous neuronal activation patterns, yet extrinsic stimulation also sculpts sensory development. Because the sensory and motor systems are interconnected in embryogenesis, how extrinsic sensory activation guides multimodal differentiation is an important topic. Further, it is unknown whether extrinsic stimulation experienced near sensory sensitivity onset contributes to persistent brain changes, ultimately affecting postnatal behavior. To determine the effects of extrinsic stimulation on multimodal development, we delivered auditory stimulation to bobwhite quail groups during early, middle, or late embryogenesis, and then tested postnatal behavioral responsiveness to auditory or visual cues. Auditory preference tendencies were more consistently toward the conspecific stimulus for animals stimulated during late embryogenesis. Groups stimulated during middle or late embryogenesis showed altered postnatal species‐typical visual responsiveness, demonstrating a persistent multimodal effect. We also examined whether auditory‐related brain regions are receptive to extrinsic input during middle embryogenesis by measuring postnatal cellular activation. Stimulated birds showed a greater number of ZENK‐immunopositive cells per unit volume of brain tissue in deep optic tectum, a midbrain region strongly implicated in multimodal function. We observed similar results in the medial and caudomedial nidopallia in the telencephalon. There were no ZENK differences between groups in inferior colliculus or in caudolateral nidopallium, avian analog to prefrontal cortex. To our knowledge, these are the first results linking extrinsic stimulation delivered so early in embryogenesis to changes in postnatal multimodal behavior and cellular activation. The potential role of competitive interactions between the sensory and motor systems is discussed. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008
Synthesis and Enzymatic Incorporation of Modified Deoxyadenosine Triphosphates
Authors: Lam Curtis , Hipolito Christopher , Perrin David M. 
Published: September 2008

AbstractSeveral deoxyadenosine triphosphates containing modifications at the 8‐position have been synthesized. Suitably protected 8‐bromodeoxyadenosines were coupled with five imidazole‐containing moieties by nucleophilic aromatic substitution or Sonagashira coupling to give modified nucleosides that were then triphosphorylated. Incorporation assays were performed for these modified residues with many commercially available DNA polymerases, and it was found that two of the modified dATPs could be effectively taken up as substrates by Sequenase V2.0. These two residues are candidates for substrates in combinatorial selections in the search for improved catalysis from DNAzymes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of New Allocolchicinoids with Seven‐ and Eight‐Membered B‐Rings by Enyne Ring‐Closing Metathesis
Authors: Boyer François‐Didier , Hanna Issam 
Published: September 2008

AbstractTotal syntheses of allocolchicines 4 and 5, with the ester functionality in the C‐ring at the C10 or C11 positions, is reported. An asymmetric synthesis of (7S)‐allocolchicine 5 is also described. The main features included the elaboration of a common intermediate, the AB bicyclic ring system, in which the construction of the seven‐membered ring was achieved by an enyne ring‐closing metathesis (RCM) reaction. A subsequent Diels–Alder/aromatization sequence afforded the set of functionalized ring‐C allocolchicinoids with high regioselectivity. This strategy was also applied for the synthesis of allocolchicine 6, containing an eight‐membered B‐ring.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Forecasting volatility with outliers in GARCH models
Authors: Charles Amélie 
Published: September 2008

AbstractIn this paper, we detect and correct abnormal returns in 17 French stocks returns and the French index CAC40 from additive‐outlier detection method in GARCH models developed by Franses and Ghijsels (1999) and extended to innovative outliers by Charles and Darné (2005). We study the effects of outlying observations on several popular econometric tests. Moreover, we show that the parameters of the equation governing the volatility dynamics are biased when we do not take into account additive and innovative outliers. Finally, we show that the volatility forecast is better when the data are cleaned of outliers for several step‐ahead forecasts (short, medium‐ and long‐term) even if we consider a GARCH‐t process. Copyright © 2008 John Wiley & Sons, Ltd.
Expectations, use and judgmental adjustment of external financial and economic forecasts: an empirical investigation
Authors: Gönül Sinan , Önkal Dilek , Goodwin Paul 
Published: September 2008

AbstractA survey of 124 users of externally produced financial and economic forecasts in Turkey investigated their expectations and perceptions of forecast quality and their reasons for judgmentally adjusting forecasts. Expectations and quality perceptions mainly related to the timeliness of forecasts, the provision of a clear justifiable rationale and accuracy. Cost was less important. Forecasts were frequently adjusted when they lacked a justifiable explanation, when the user felt they could integrate their knowledge into the forecast, or where the user perceived a need to take responsibility for the forecast. Forecasts were less frequently adjusted when they came from a well‐known source and were based on sound explanations and assumptions. The presence of feedback on accuracy reduced the influence of these factors. The seniority and experience of users had little effect on their attitudes or propensity to make adjustments. Copyright © 2008 John Wiley & Sons, Ltd.
Sports forecasting: a comparison of the forecast accuracy of prediction markets, betting odds and tipsters
Authors: Spann Martin , Skiera Bernd 
Published: September 2008

AbstractThis article compares the forecast accuracy of different methods, namely prediction markets, tipsters and betting odds, and assesses the ability of prediction markets and tipsters to generate profits systematically in a betting market. We present the results of an empirical study that uses data from 678–837 games of three seasons of the German premier soccer league. Prediction markets and betting odds perform equally well in terms of forecasting accuracy, but both methods strongly outperform tipsters. A weighting‐based combination of the forecasts of these methods leads to a slightly higher forecast accuracy, whereas a rule‐based combination improves forecast accuracy substantially. However, none of the forecasts leads to systematic monetary gains in betting markets because of the high fees (25%) charged by the state‐owned bookmaker in Germany. Lower fees (e.g., approximately 12% or 0%) would provide systematic profits if punters exploited the information from prediction markets and bet only on a selected number of games. Copyright © 2008 John Wiley & Sons, Ltd.
Parsimonious modeling and forecasting of corporate yield curve
Authors: Yu Wei‐Choun , Salyards Donald M. 
Published: September 2008

AbstractThis paper investigates the sensitivity of out‐of‐sample forecasting performance over a span of different parameters of l in the dynamic Nelson–Siegel three‐factor AR(1) model. First, we find that the ad hoc selection of l is not optimal. Second, we find a substantial difference in factor dynamics between investment‐grade and speculative‐grade corporate bonds from 1994:12 to 2006: 4. Third, we suggest that the three‐factor model is sufficient to explain the main variations of corporate yield changes. Finally, the parsimonious Nelson–Siegel three‐factor AR(1) model remains competitive in the out‐of‐sample forecasting of corporate yields. Copyright © 2008 John Wiley & Sons, Ltd.