bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating Residential Water Demand Under Systematic Shifts Between Uniform Price (UP) and Increasing Block Tariffs (IBT)
Authors: Chovar Vera A. M. , Vásquez‐Lavín F. A. , Ponce Oliva R. 
Published: April 2024

AbstractWe evaluate whether changing from a uniform price (UP) to an increasing block tariff (IBT) changes people's behavior. We exploit a unique setting in which the price scheme moves back and forth yearly from UP to IBT. We discuss the effectiveness of IBT in reducing summer consumption. This issue is relevant to many countries and policymakers interested in designing tariff structures. There is no evidence of how the same consumer may react to systematically switching from one tariff structure to another yearly. We estimate the residential water demand and its price elasticity using a generalized least squared random effect model for the UP and the discrete/continuous choice model for the IBT. In addition, we split the sample between low and high‐consumption groups. For the low consumption group unaffected by the tariff change, the elasticity in the nonsummer months is higher (more elastic) than in the summer. Consumers in this group reduce their elasticity from nonsummer to summer months (−0.299 vs. −0.071, respectively) and increase their consumption by 13%. The high consumption group increased its summer consumption, but only by 8.7%, and contrary to the first group, its elasticity increased significantly (from −0.299 to −0.568). The high‐consumption group is indeed affected by the change in tariff. From a policy perspective, this implies that the IBT structure is relevant. However, if the policy seeks to promote conservation, it needs to be adjusted to a lower decile of the water consumption distribution to affect a more significant portion of the population.
Impact of Seawater Inorganic Carbon Chemistry on Element Incorporation in Foraminiferal Shell Carbonate
Authors: Karancz S. , de Nooijer L. J. , Brummer G. J. A. , Lattaud J. , Haghipour N. , Rosenthal Y. , Reichart G. J. 
Published: April 2024

AbstractReconstruction of the marine inorganic carbon system relies on proxy signal carriers, such as element/calcium (El/Ca) ratios in foraminiferal shells. Concentrations of boron, lithium, strontium, and sulfur have been shown to vary with carbonate system parameters, but when comparing individual proxy reconstructions based on these elements, they are rarely in complete agreement. This is likely caused by the simultaneous effects of multiple environmental factors on element incorporation. Culture experiments with benthic foraminifera have revealed that the shell's S/Ca reflects the carbon chemistry and can potentially be used as a proxy for seawater []. Aiming to investigate the application potential of sulfur incorporation for carbonate speciation reconstruction, we present S/Ca ratios in five planktonic foraminiferal species, namely Globigerina bulloides, Globigerinoides ruber albus, Globigerinoides ruber ruber, Trilobatus sacculifer, and Neogloboquadrina incompta from core‐top sediments in regions with contrasting [], [], temperature, and salinity. Analyses of B/Ca and Mg/Ca ratios are included here since these elements have been shown to depend to a certain degree on carbon system parameters (e.g., calcite saturation state and pH, respectively) as well. Moreover, foraminiferal Mg/Ca values covary with S/Ca values and thereby might compromise its proxy application. In contrast to previously published results, this new data set shows a positive correlation between the incorporation of sulfur in the foraminifer's shell and seawater []. As the incorporation of sulfur and magnesium are positively correlated, S/Mg values of the same foraminifera may be used to improve inorganic carbon system reconstructions.
Three‐Dimensional Water Exchanges in the Shelf Circulation System of the Northern South China Sea Under Climatic Modulation From ENSO
Authors: Cui Lingbo , Liu Zhiqiang , Chen Ying , Cai Zhongya 
Published: April 2024

AbstractUsing the numerical calculations of exposure time (), this study investigated the three‐dimensional characteristics of water exchanges associated with the coastal‐shelf circulations of the Northern South China Sea (NSCS). The circulation connectivity and its interannual variability under the modulation of El Niño Southern Oscillation (ENSO) were investigated. The gradually increased from approximately 50 days over the outer shelf to more than 150 days in the shallower coastal seas with the Beibu Gulf displaying a significantly longer (approximately 300 days). The Beibu Gulf played an influential role in the water exchange that had a contribution of over 30% to in the most regions. The results from sensitivity experiments indicate that the wind forcing is the primary controller of and the boundary flux plays a secondary role. Specifically, the wind enhances water exchange in western NSCS, particularly in the Beibu Gulf and Yuexi region. Conversely, boundary fluxes facilitate exchanges in the eastern shelf, such as Yuedong region. Analysis revealed a clear modulation from ENSO on water exchange, wherein El Niño and La Niña years displayed symmetrical morphologies in distribution anomalies, albeit with varying intensities. During El Niño years, the weakened southwestward shelf current increased and the shelf water was less likely to reach the Beibu Gulf, and once arrived, these waters were trapped inside to elongate . In contrast, during La Niña years, the strengthened southwestward shelf current shortened and more shelf waters were transported away from the NSCS by an intensified southwestward shelf current.
Quantifying Supraglacial Debris‐Related Melt‐Altering Effects on the Djankuat Glacier, Caucasus, Russian Federation
Authors: Verhaegen Yoni , Rybak Oleg , Popovnin Victor V. , Huybrechts Philippe 
Published: April 2024

AbstractWe use a spatially distributed and physically based energy and mass balance model to derive the Østrem curve, which expresses the supraglacial debris‐related relative melt alteration versus the debris thickness, for the Djankuat Glacier, Caucasus, Russian Federation. The model is driven by meteorological data from two on‐glacier weather stations and ERA‐5 Land reanalysis data. A direct pixel‐by‐pixel comparison of the melt rates obtained from both a clean ice and debris‐covered ice mass balance model results in the quantification of debris‐related relative melt‐modification ratios, capturing the degree of melt enhancement or suppression as a function of the debris thickness. The main results show that the distinct surface features and different surface temperature/moisture and near‐surface wind regimes that persist over debris‐covered ice significantly alter the pattern of the energy and mass fluxes when compared to clean ice. Consequently, a maximum relative melt enhancement of 1.36 is modeled on the glacier for thin/patchy debris with a thickness of 0.03 m. However, insulating effects suppress sub‐debris melt under debris layers thicker than a critical debris thickness of 0.09 m. Sensitivity experiments show that especially within‐debris properties, such as the thermal conductivity and the vertical debris porosity gradient, highly impact the magnitude of the sub‐debris melt rates. Our results also highlight the scale‐dependency as well as the dynamic nature of the debris thickness‐melt relationship for changing climatic conditions, which may have significant implications for the climate change response of debris‐covered glaciers.
Patient-reported outcomes in Primary Spinal Intradural Tumours: a systematic review
Authors: Ali Ahmad M. S. , Mustafa Mohammad A. , Ali Omar M. E. , Gillespie Conor S. , Richardson George M. , Clark Simon , Wilby Martin J. , Millward Christopher P. , Srikandarajah Nisaharan 
Published: April 2024

Abstract
Study design
Systematic review.

Objectives
Primary Spinal Intradural Tumours (PSITs) are rare pathologies that can significantly impact quality of life. This study aimed to review patient reported outcomes (PROs) in PSITs.

Methods
A systematic search of Pubmed and Embase was performed to identify studies measuring PROs in adults with PSITs. PRO results were categorised as relating to Global, Physical, Social, or Mental health. Outcomes were summarised descriptively.

Results
Following review of 2382 records, 11 studies were eligible for inclusion (737 patients). All studies assessed surgically treated patients. Schwannoma was the commonest pathology (n = 190). 7 studies measured PROs before and after surgery, the remainder assessed only post-operatively. For eight studies, PROs were obtained within 12 months of treatment. 21 PRO measurement tools were used across included studies, of which Euro-Qol-5D (n = 8) and the pain visual/numerical analogue scale (n = 5) were utilised most frequently. Although overall QoL is lower than healthy controls in PSITs, improvements following surgery were found in Extramedullary tumours (EMT) in overall physical, social, and mental health. Similar improvements were not significant across studies of Intramedullary tumours (IMT). Overall QoL and symptom burden was higher in IMT patients than in brain tumour patients. No studies evaluated the effect of chemotherapy or radiotherapy.

Conclusion
Patients with PSITs suffer impaired PROs before and after surgery. This is particularly true for IMTs. PRO reporting in PSITs is hindered by a heterogeneity of reporting and varied measurement tools. This calls for the establishment of a standard set of PROs as well as the use of registries.
Methylation in cornea and corneal diseases: a systematic review
Authors: Xia Yutong , Chen Kuangqi , Yang Qianjie , Chen Zhitong , Jin Le , Zhang Liyue , Yu Xin , Wang Liyin , Xie Chen , Zhao Yuan , Shen Ye , Tong Jianping 
Published: April 2024

AbstractCorneal diseases are among the primary causes of blindness and vision loss worldwide. However, the pathogenesis of corneal diseases remains elusive, and diagnostic and therapeutic tools are limited. Thus, identifying new targets for the diagnosis and treatment of corneal diseases has gained great interest. Methylation, a type of epigenetic modification, modulates various cellular processes at both nucleic acid and protein levels. Growing evidence shows that methylation is a key regulator in the pathogenesis of corneal diseases, including inflammation, fibrosis, and neovascularization, making it an attractive potential therapeutic target. In this review, we discuss the major alterations of methylation and demethylation at the DNA, RNA, and protein levels in corneal diseases and how these dynamics contribute to the pathogenesis of corneal diseases. Also, we provide insights into identifying potential biomarkers of methylation that may improve the diagnosis and treatment of corneal diseases.
Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma
Authors: Cai Liuyang , Zhu Hengyan , Mou Qianqian , Wong Po Yee , Lan Linlin , Ng Cherrie W. K. , Lei Pu , Cheung Man Kit , Wang Daijuanru , Wong Eddy W. Y. , Lau Eric H. L. , Yeung Zenon W. C. , Lai Ronald , Meehan Katie , Fung Sherwood , Chan Kwan Chee A. , Lui Vivian W. Y. , Cheng Alfred S. L. , Yu Jun , Chan Paul K. S. , Chan Jason Y. K. , Chen Zigui 
Published: April 2024

AbstractDysbiosis of the human oral microbiota has been reported to be associated with oral cavity squamous cell carcinoma (OSCC) while the host-microbiota interactions with respect to the potential impact of pathogenic bacteria on host genomic and epigenomic abnormalities remain poorly studied. In this study, the mucosal bacterial community, host genome-wide transcriptome and DNA CpG methylation were simultaneously profiled in tumors and their adjacent normal tissues of OSCC patients. Significant enrichment in the relative abundance of seven bacteria species (Fusobacterium nucleatum, Treponema medium, Peptostreptococcus stomatis, Gemella morbillorum, Catonella morbi, Peptoanaerobacter yurli and Peptococcus simiae) were observed in OSCC tumor microenvironment. These tumor-enriched bacteria formed 254 positive correlations with 206 up-regulated host genes, mainly involving signaling pathways related to cell adhesion, migration and proliferation. Integrative analysis of bacteria-transcriptome and bacteria-methylation correlations identified at least 20 dysregulated host genes with inverted CpG methylation in their promoter regions associated with enrichment of bacterial pathogens, implying a potential of pathogenic bacteria to regulate gene expression, in part, through epigenetic alterations. An in vitro model further confirmed that Fusobacterium nucleatum might contribute to cellular invasion via crosstalk with E-cadherin/β-catenin signaling, TNFα/NF-κB pathway and extracellular matrix remodeling by up-regulating SNAI2 gene, a key transcription factor of epithelial-mesenchymal transition (EMT). Our work using multi-omics approaches explored complex host-microbiota interactions and provided important insights into genetic and functional basis in OSCC tumorigenesis, which may serve as a precursor for hypothesis-driven study to better understand the causational relationship of pathogenic bacteria in this deadly cancer.
Social isolation and the risk of Parkinson disease in the UK biobank study
Authors: Geng Tingting , Li Yaqi , Peng Yinshun , Chen Xiao , Xu Xinming , Wang Jian , Sun Liang , Gao Xiang 
Published: April 2024

AbstractParkinson disease (PD) has become one of the most rapidly growing causes of disability among the older population and social isolation is a major concern in the PD community. However, the relationship between social isolation and future risk of PD remains unclear. This study included 192,340 participants aged 60 or older who were free of dementia and PD at baseline from the UK Biobank study. Social isolation was measured using a composite score derived from three questions on number in household, frequency of friend/family visits, and leisure/social activities. Incident PD cases were identified through electronic health records. Multivariable-adjusted Cox regression models were used to compute the hazard ratio (HR) and 95% confidence interval (CI). Among the 192,340 participants (mean [standard deviation] age, 64.2 [2.9] years; 103,253 [53.7%] women), 89,075 (46.3%) participants were in the least isolated group and 26,161 (13.6%) were in the most isolated group. Over a median follow-up of 12.5 years, 2048 incident PD cases were documented. Compared to the least isolated group, the multivariable-adjusted HRs (95% CIs) for PD were 1.00 (0.91−1.10) for the moderately isolated group and 1.19 (1.05−1.36) for the most isolated group (P-trend = 0.04). The observed association was independent of the genetic susceptibility to PD and consistent in subgroup analyses. Social isolation was associated with a higher risk of PD regardless of genetic risk. Our findings highlighted the importance of developing screening and intervention strategies for social isolation among older adults to reduce the risk of PD.
Underestimated burden of per- and polyfluoroalkyl substances in global surface waters and groundwaters
Authors: Ackerman Grunfeld Diana , Gilbert Daniel , Hou Jennifer , Jones Adele M. , Lee Matthew J. , Kibbey Tohren C. G. , O’Carroll Denis M. 
Published: April 2024

AbstractPer- and polyfluoroalkyl substances (PFAS) are a class of fluorinated chemicals used widely in consumer and industrial products. Their human toxicity and ecosystem impacts have received extensive public, scientific and regulatory attention. Regulatory PFAS guidance is rapidly evolving, with the inclusion of a wider range of PFAS included in advisories and a continued decrease in what is deemed safe PFAS concentrations. In this study we collated PFAS concentration data for over 45,000 surface and groundwater samples from around the world to assess the global extent of PFAS contamination and their potential future environmental burden. Here we show that a substantial fraction of sampled waters exceeds PFAS drinking water guidance values, with the extent of exceedance depending on the jurisdiction and PFAS source. Additionally, current monitoring practices probably underestimate PFAS in the environment given the limited suite of PFAS that are typically quantified but deemed of regulatory concern. An improved understanding of the range of PFAS embodied in consumer and industrial products is required to assess the environmental burden and develop mitigation measures. While PFAS is the focus of this study, it also highlights society’s need to better understand the use, fate and impacts of anthropogenic chemicals.
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Authors: Hacisuleyman Ezgi , Hale Caryn R. , Noble Natalie , Luo Ji-dung , Fak John J. , Saito Misa , Chen Jin , Weissman Jonathan S. , Darnell Robert B. 
Published: April 2024

AbstractLearning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are unclear. In this study, to monitor how depolarization impacts local dendritic biology, we employed a dendritically targeted proximity labeling approach followed by crosslinking immunoprecipitation, ribosome profiling and mass spectrometry. Depolarization of primary cortical neurons with KCl or the glutamate agonist DHPG caused rapid reprogramming of dendritic protein expression, where changes in dendritic mRNAs and proteins are weakly correlated. For a subset of pre-localized messages, depolarization increased the translation of upstream open reading frames (uORFs) and their downstream coding sequences, enabling localized production of proteins involved in long-term potentiation, cell signaling and energy metabolism. This activity-dependent translation was accompanied by the phosphorylation and recruitment of the non-canonical translation initiation factor eIF4G2, and the translated uORFs were sufficient to confer depolarization-induced, eIF4G2-dependent translational control. These studies uncovered an unanticipated mechanism by which activity-dependent uORF translational control by eIF4G2 couples activity to local dendritic remodeling.
The Caribbean and Mesoamerica Biogeochemical Isotope Overview (CAMBIO)
Authors: Ebert Claire E. , Hixon Sean W. , Buckley Gina M. , George Richard J. , Pacheco-Fores Sofía I. , Palomo Juan Manuel , Sharpe Ashley E. , Solís-Torres Óscar R. , Davis J. Britt , Fernandes Ricardo , Kennett Douglas J. 
Published: April 2024

AbstractThe Caribbean & Mesoamerica Biogeochemical Isotope Overview (CAMBIO) is an archaeological data community designed to integrate published biogeochemical data from the Caribbean, Mesoamerica, and southern Central America to address questions about dynamic interactions among humans, animals, and the environment in the region over the past 10,000 years. Here we present the CAMBIO human dataset, which consists of more than 16,000 isotopic measurements from human skeletal tissue samples (δ13C, δ15N, δ34S, δ18O, 87Sr/86Sr, 206/204Pb, 207/204Pb, 208/204Pb, 207/206Pb) from 290 archaeological sites dating between 7000 BC to modern times. The open-access dataset also includes detailed chronological, contextual, and laboratory/sample preparation information for each measurement. The collated data are deposited on the open-access CAMBIO data community via the Pandora Initiative data platform (https://pandoradata.earth/organization/cambio).
The first absolute gravity and height reference network in Sicily
Authors: Greco Filippo , Berrino Giovanna , Riguzzi Federica , Mazzoni Augusto , Amendola Matteo , Carbone Daniele , Contrafatto Danilo , Dardanelli Gino , Brutto Mauro Lo , Maltese Antonino , Messina Alfio , Mirabella Luca , Ricciardi Giuseppe , Samperi Luca 
Published: April 2024

AbstractThe purpose of this work is to provide the methodological and instrumental framework for the establishment of a new absolute gravity and height reference network in Sicily. The aim of the network is to contribute to the new reference systems in the Italian area, useful for the scientific and technological activities related to the gravity field and to the proper definition of a modern height system in this region. The network is composed of 5 stations, evenly distributed to form a large mesh, which roughly covers the entire Sicily. Since four of the five selected stations were measured also in the 1990s, it was also possible to evaluate whether long-term gravity changes occurred at these sites (basic requirement for a reference network) and check the long-term ground deformation patterns, using data from the closest GPS/GNSS stations. The observed gravity changes over a time interval of about 30 years at the absolute stations and in the surrounding areas, confirm the long-term stability of the selected areas/sites.
A large normative connectome for exploring the tractographic correlates of focal brain interventions
Authors: Elias Gavin J. B. , Germann Jürgen , Joel Suresh E. , Li Ningfei , Horn Andreas , Boutet Alexandre , Lozano Andres M. 
Published: April 2024

AbstractDiffusion-weighted MRI (dMRI) is a widely used neuroimaging modality that permits the in vivo exploration of white matter connections in the human brain. Normative structural connectomics – the application of large-scale, group-derived dMRI datasets to out-of-sample cohorts – have increasingly been leveraged to study the network correlates of focal brain interventions, insults, and other regions-of-interest (ROIs). Here, we provide a normative, whole-brain connectome in MNI space that enables researchers to interrogate fiber streamlines that are likely perturbed by given ROIs, even in the absence of subject-specific dMRI data. Assembled from multi-shell dMRI data of 985 healthy Human Connectome Project subjects using generalized Q-sampling imaging and multispectral normalization techniques, this connectome comprises ~12 million unique streamlines, the largest to date. It has already been utilized in at least 18 peer-reviewed publications, most frequently in the context of neuromodulatory interventions like deep brain stimulation and focused ultrasound. Now publicly available, this connectome will constitute a useful tool for understanding the wider impact of focal brain perturbations on white matter architecture going forward.
EEG and fNIRS datasets based on Stroop task during two weeks of high-altitude exposure in new immigrants
Authors: Ji Xiang , Bao Botao , Li Lin Z. , Pu Jiangbo , Lin Yu , Zhang Xin , Chen Zemeng , Li Ting 
Published: April 2024

AbstractMaintaining sufficient cerebral oxygen metabolism is crucial for human survival, especially in challenging conditions such as high-altitudes. Human cognitive neural activity is sensitive to fluctuations in oxygen levels. However, there is a lack of publicly available datasets on human behavioural responses and cerebral dynamics assessments during the execution of conflicting tasks in natural hypoxic environments. We recruited 80 healthy new immigrant volunteers (males, aged 20 ± 2 years) and employed the Stroop cognitive conflict paradigm. After a two-week exposure to both high and low-altitudes, the behavioural performance, prefrontal oxygen levels, and electroencephalography (EEG) signals were recorded. Comparative analyses were conducted on the behavioural reaction times and accuracy during Stroop tasks, and statistical analyses of participants’ prefrontal oxygen levels and EEG signals were performed. We anticipate that our open-access dataset will contribute to the development of monitoring devices and algorithms, designed specifically for measuring cerebral oxygen and EEG dynamics in populations exposed to extreme environments, particularly among individuals suffering from oxygen deficiency.