bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life of individuals with serious mental illness and family caregivers
Authors: de Medina-Moragas Alejandro Jesús , Lima-Serrano Marta , Fernández-Fernández María José , Lima-Rodríguez Joaquín Salvador 
Published: April 2024

Abstract
The well-being and satisfaction of individuals with serious mental illnesses (SMI) and their family caregivers are less than desirable. Research on the quality of life (QoL) of individuals with SMI and their caregivers, including disorders other than schizophrenia, is limited. Thus, this study aimed to investigate the self-perception of QoL in patients with SMI and their family caregivers and the associated factors. This cross-sectional study was conducted in patients with SMI and their caregivers who completed self-assessment instruments to determine their QoL. Social support and burden in caregivers and symptomatology levels in individuals with SMI were assessed. The physical aspect of QoL in individuals with SMI was associated with employment status and symptom severity. The physical component of caregivers’ QoL was associated with kinship relationship, the presence of other family members with disabilities, social support, and age. The mental component was associated with global symptomatology and the diagnosis of major depression in individuals with SMI and caregiver burden in family members. In conclusion, these findings on correlated factors of QoL in individuals with SMI and their caregivers could be used in developing therapeutic interventions for mental health.

Plain summary
A significant number of people with serious mental health problems and their families often endure poor quality of life. However, research on how these individuals truly feel about their lives is limited. This study aimed to explore the perceptions of quality of life among individuals with serious mental health issues and their family caregivers in Spain. We sought to understand the personal sentiments of these individuals and their caregivers regarding their quality of life and the factors that influence it. Our findings indicate that job status, symptoms of the illness, and family relationships play crucial roles in how these individuals view their quality of life. Additionally, caregivers' age, support they receive, and the challenges they face in their families can influence their feelings. This implies that, to enhance their lives, it is crucial to consider these factors and provide appropriate support.
The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment
Authors: Devita Maria , Debiasi Giulia , Anglani Mariagiulia , Ceolin Chiara , Mazzonetto Ilaria , Begliomini Chiara , Cauzzo Simone , Raffaelli Cecilia , Lazzarin Alessandro , Ravelli Adele , Bordignon Alessandra , De Rui Marina , Sergi Giuseppe , Bertoldo Alessandra , Mapelli Daniela , Coin Alessandra 
Published: April 2024

AbstractThe present study aims to investigate the relationship between cerebellar volumes and cognitive reserve in individuals with Mild Cognitive Impairment (MCI). A description of proxies of cerebellar cognitive reserve in terms of different volumes across lobules is also provided. 36 individuals with MCI underwent neuropsychological (MoCA, MMSE, Clock test, CRIq) assessment and neuroimaging acquisition with magnetic resonance imaging at 3 T. Simple linear correlations were applied between cerebellar volumes and cognitive measures. Multiple linear regression models were then used to estimate standardized regression coefficients and 95% confidence intervals. Simple linear correlations between cerebellar lobules volumes and cognitive features highlighted a significant association between CRIq_Working activity and specific motor cerebellar volumes: Left_V (ρ = 0.40, p = 0.02), Right_V (r = 0.42, p = 0.002), Vermis_VIIIb (ρ = 0.47, p = 0.003), Left_X (ρ = -0.46, p = 0.002) and Vermis_X (r = 0.35, p = 0.03). Furthermore, CRIq_Working activity scores correlated with certain cerebellar lobules implicated in cognition: Left_Crus_II, Vermis VIIb, Left_IX. MMSE was associated only with the Right_VIIB volume (r = 0.35, p = 0.02), while Clock Drawing Test scores correlated with both Left_Crus_I and Right_Crus_I (r = -0.42 and r = 0.42, p = 0.02, respectively). This study suggests that a higher cognitive reserve is associated with specific cerebellar lobule volumes and that Working activity may play a predominant role in this association. These findings contribute to the understanding of the relationship between cerebellar volumes and cognitive reserve, highlighting the potential modulatory role of Working activity on cerebellum response to cognitive decline.
Graphical Abstract
What we already know about corporate digital responsibility in IS research: A review and conceptualization of potential CDR activities
Authors: Carl K. Valerie , Hinz Oliver 
Published: April 2024

AbstractAdvances in new technologies affect private and professional lives alike, posing new opportunities and threats for companies, consumers, and society. In this context, the concept of corporate digital responsibility (CDR) gains traction enabling technologies benefitting humanity while exceeding mere technology advancements. Yet, theory and practice still lack a systematic in-depth understanding of the concept’s scope up to concrete activities. The aim of this paper is to enable a more concrete and deeper understanding of the concept scope by drawing on available knowledge in the thematically related discipline of information systems (IS) in general and electronic markets in particular. The study employs an extended systematic literature review to aggregate prior knowledge in this research domain relatable to the concept of CDR and to develop an in-depth classification of potential CDR activities inductively according to ten dimensions, corresponding sub-dimensions, and respective fields of action. This contributes to the overarching goal to develop the conceptualization of CDR and to anchor the concept in the context of electronic markets, thereby fostering human and social value creation.
SLC35A2 expression is associated with HER2 expression in breast cancer
Authors: Wang Yiran , Peng Xiaobo , Wu Meihong , Wang Bin , Chen Tianran , Zhan Xianbao 
Published: April 2024

AbstractThe role of SLC35A2 in breast cancer remains poorly understood, with limited available information on its significance. This study aimed to investigate the expression of SLC35A2 and clinicopathological variables in breast cancer patients. Immunohistochemical analysis of SLC35A2 protein was conductedon 40 adjacent non-neoplastic tissues and 320 breast cancer tissues. The study also assesed the association between SLC35A2 expression and breast cancer clinicopathological features of breast cancer, as well as its impact on overall survival. In comparison to adjacent non-neoplastic tissues, a significantly higher expression of SLC35A2 was observed in breast cancer tissues (P = 0.020), and this expression was found to be independently correlated with HER2 positivity (P = 0.001). Survival analysis indicated that patients with low SLC35A2 expression had a more favorable prognosis in HER2-positive subtype breast cancer (P = 0.017). These results suggest that SLC35A2 is overexpressed in breast cancer tissues compared to adjacent non-neoplastic tissues and may serve as a potential prognostic marker for HER2-positive subtype breast cancer. Furthermore, breast cancer patients with the HER2 positive subtype who exhibited decreased levels of SLC35A2 expression demonstrated improved long-term prognostic outcomes.
Are Biology Experts and Novices Function Pluralists?
Authors: Roberts Andrew J. , Bourrat Pierrick 
Published: April 2024

AbstractPhilosophers have proposed many accounts of biological function. A coarse-grained distinction can be made between backward-looking views, which emphasise historical contributions to fitness, and forward-looking views, which emphasise the current contribution to fitness or role of a biological component within some larger system. These two views are often framed as being incompatible and conflicting with one another. The emerging field of synthetic biology, which involves applying engineering principles to the design and construction of biological systems, complicates things further by adding intentional design as a source of function. In the current study we explored how biology experts and novices think about function in the context of single-celled, multi-celled, and synthetic organisms. We also explored the extent to which each group were function pluralists, and if they were function pluralists, which accounts of function tended to be endorsed together. The results showed a surprising degree of similarity between experts and novices in most contexts, although certain differences were apparent. Most surprisingly, we found evidence not only of function pluralism in both groups, but pluralism between backward-looking and forward-looking accounts. We discuss these findings in the context of the philosophical debate on function and consider the practical implications for public acceptance of synthetic biology. First, we argue that philosophers of biology should re-examine the purported incompatibility between accounts of function. Second, we argue that due to the introduction of an intentional aetiology in synthetic biology, there may be an inherent conflict between the views of experts and novices when thinking about synthetic biology.
Building stewardship capacity through fishers’ knowledge and advocacy in fisheries management: a case study from Southeast Alaska
Authors: Scalisi Emma D. , Beaudreau Anne H. , Mason Ellie 
Published: April 2024

AbstractLocal environmental stewardship supports resilience of social-ecological systems through a wide range of actions that benefit both environmental and human wellbeing. Stewardship actions of harvesters have been recognized as an important component in building adaptive capacity of coastal fisheries undergoing change. In Southeast Alaska, where commercial fishing plays a key role in cultures and economies, concerns for local fisheries have arisen from declines in salmon returns, high price variability, and barriers to participation, among other issues. Here, we aimed to understand existing and potential pathways for stewardship actions of small-boat commercial fishers in Juneau, Alaska. We conducted semi-structured interviews with 22 commercial fishers, agency staff, and leaders of seafood associations to document fisher-led stewardship actions and ways that small-boat commercial fishers engage formally and informally with local management, explore the role of fishery management agencies in facilitating collaboration and communication with fishers in the Juneau area, and understand local perspectives on how the stewardship capacities of the fishery system can be better supported. We found that multiple pathways for stewardship exist in commercial salmon and shellfish fisheries, including formal and informal interactions with state fishery management staff and decision-makers, participation in fishing associations and advocacy organizations, knowledge sharing among fishers, and taking personal conservation actions to care for fisheries. We identified areas of relatively low social, financial, and institutional capital that may limit the effectiveness of these stewardship actions. Our findings highlight diverse perspectives of fishery participants on how these stewardship actions might be better supported through policy, advocacy, and collaboration.
Seismic Bearing Capacity of a Footing on Sloping Frictional Soil
Authors: Garzón-Roca Julio , Melentijevic Svetlana 
Published: April 2024

AbstractThis study presents the analysis of surficial strip footing on sloping frictional ground for an easy estimation of its seismic bearing capacity (by means of a seismic slope coefficient) to be used in conjunction with any other analytical solution provided for the static case. The influence of the slope angle and height, proximity of the slope to the crest, and value of the pseudo-static seismic coefficient is presented. A parametric study performed for the range of these geometrical and geotechnical parameters is conducted by the finite element method, also presenting the analysis of failure modes. The results are summarized in the form of non-dimensional charts that could be easily used for the estimation of the seismic bearing capacity by practitioners. An example of the application of charts is presented. It can be concluded that there is no influence of the sloping ground when the distance of the footing is greater than four times the width. For the horizontal seismic coefficients greater than 0.3 g, the shallow foundations should not be placed near the slope.
Structure-property relationship and emerging applications of nano- and micro-sized fillers reinforced sialon composites: a review
Authors: Ogunbiyi Olugbenga , Jamiru Tamba , Adekoya Gbolahan Joseph , Rominiyi Azeez Lawan 
Published: April 2024

AbstractOxonitridoaluminosilicates (SiAlON) are renowned in advanced ceramics for their exceptional properties: high temperature stability, excellent oxidation resistance, and good wear resistance. Incorporating micro- and nano-sized fillers into SiAlON matrices enhances their properties, yielding SiAlON composite materials with superior mechanical, tribological, and thermal characteristics. This review examines fabrication techniques for producing SiAlON micro/nanocomposites and the structure-property relationships governing their performance across different phase compositions (β, α, X, and O-phases). A comprehensive literature review scrutinized fabrication techniques and structure-property relationships from various databases and scholarly articles. Although SiAlON composites with micro/nano inclusions hold promise across applications, understanding their fabrication processes, structure-property relationships, and potential applications in different fields is crucial. The review highlights diverse fabrication techniques for SiAlON micro/nanocomposites and provides insights into their structure-property relationships. Additionally, emerging applications in structural domains, cutting tools, coatings, corrosion protection, solar cells, LEDs, biomedical realms, and filtration membranes are discussed. This review is a valuable resource for researchers and engineers interested in designing SiAlON products tailored for sophisticated applications. It emphasizes understanding fabrication processes and structure-property relationships to unlock SiAlON-based materials' full potential across industries.
Long-term effects of biochar one-off application on soil physicochemical properties, salt concentration, nutrient availability, enzyme activity, and rice yield of highly saline-alkali paddy soils: based on a 6-year field experiment
Authors: Jin Feng , Piao Junlong , Miao Shihao , Che Weikang , Li Xiang , Li Xuebin , Shiraiwa Tatsuhiko , Tanaka Tomoyuki , Taniyoshi Kazuki , Hua Shuang , Lan Yu 
Published: April 2024

AbstractBiochar application can alleviate the adverse effects of saline-alkali stress on crops. However, the long-term effects of one-off biochar application on soil physicochemical properties, salt concentration, nutrient availability, soil enzyme activities, and rice yield under highly saline-alkali paddy soils remain unclear. Here, a 6-year paddy field study was conducted in a saline-alkali paddy field using two nitrogen application levels (0 and 225 kg ha−1) and four biochar application rates [0 (T0), 1.5% (T1.5), 3.0% (T3.0), and 4.5% (T4.5) biochar, w/w]. The results showed that compared with T0, the bulk density (BD) under T1.5, T3.0, and T4.5 treatments significantly decreased by 11.21%, 16.33%, and 25.57%, while total porosity (Tp) and saturated hydraulic conductivity (Ks) increased by 19.15–27.34% and 3217.78–5539.83%, respectively. Biochar consistently improved soil macro-aggregates, mean weight diameter (MWD), and the percentage of water-stable aggregates (PWSA) over the years. Additionally, one-off application of biochar continuously reduced the soil Na+ concentration, Na+/K+ ratio, Na+/Ca2+ ratio, saturated paste extract (ECe), exchangeable sodium percentage (ESP), and sodium adsorption ratio (SARe). However, it reduced the pH in 2021 and 2022 only. It enhanced the concentration of K+, Ca2+, Mg2+, and cation exchange capacity (CEC) over the 6-year study, indicating its longer-term positive impact. Furthermore, the one-off biochar application, especially under high application rate treatments (T3.0 and T4.5), significantly and continuously improved nutrient availability and soil enzyme activities. However, alkali-hydrolysable nitrogen (AN) decreased in the initial year of biochar application. The grain yield of T1.5, T3.0, and T4.5 surpassed that of T0 by 116.38%, 141.24%, and 145.20%, respectively. Notably, the rice yield reached its peak with the treatment of 3.0% (w/w) in all 6 years of study period. These findings offered new perspectives on repairing and improving soil quality and production ability of highly saline-alkali paddy soils.
Graphical Abstract
Virtual design on the heat pump refrigeration cycle: challenges and approaches
Authors: Hwang Yoon Jei , Park Noma 
Published: April 2024

AbstractVirtual product design (VPD) of the refrigeration cycle has long been a major subject of many engineers and manufacturers. Issues should be the question of how simulation gets close to the real world in virtual ways. It is especially true when we consider variable refrigerant flow (VRF) heat pumps, having various types of indoor unit combinations, long and complicated piping configurations, and simultaneous cooling and heating functions under extreme weather conditions. In this regard, model-based systems engineering (MBSE) or model-based design (MBD) guides a methodology to make a virtual model easily. Now, there are plenty of engineering platforms and tools to make a strong simulation model, which provides interfacing technology among multiple physics, different dimensions, and codes in different languages. In the study, the authors share their experience in the virtual design for a VRF heat pump system including the architecture, multiple physics, and the connection with the control SW. Modelica, an acausal and object-oriented modeling language, constructs the backbone of the model to describe the dynamic behavior of refrigerants and to combine external components in the form of functional mock-up units (FMUs). The developed virtual model is validated against measured data, showing it can reproduce all the essential physics of interest both in qualitative and quantitative ways.
Workflow and Outcome of Thrombectomy in Late Time Window: A Pooled Multicenter Analysis
Authors: Ademola Ayoola , Bala Fouzi , Menon Bijoy K. , Thornton John , Casetta Ilaria , Nannoni Stefania , Goyal Mayank , Herlihy Darragh , Fainardi Enrico , Power Sarah , Saia Valentina , Hegarty Aidan , Pracucci Giovanni , Demchuk Andrew , Mangiafico Salvatore , Boyle Karl , Michel Patrik , Hildebrand Kevin A. , Sajobi Tolulope T. , Hill Michael D. , Toni Danilo , Murphy Sean , Kim Beom Joon , Almekhlafi Mohammed A. 
Published: April 2024

ABSTRACT:Background:We investigated the impact of workflow times on the outcomes of patients treated with endovascular thrombectomy (EVT) in the late time window.Methods:Individual patients’ data who underwent EVT in the late time window (onset to imaging >6 hours) were pooled from seven registries and randomized clinical trials. Multiple time intervals were analyzed. Mixed-effects logistic regression was used to estimate the likelihood of functional independence at 90 days (modified Rankin Scale 0–2). Mixed-effects negative binomial regression was used to evaluate the relationship between patient characteristics and workflow time intervals.Results:608 patients were included. The median age was 70 years (IQR: 58–71), 307 (50.5%) were female, and 310 (53.2%) had wake-up strokes. Successful reperfusion was achieved in 493 (81.2%) patients, and 262 (44.9%) achieved 90-day mRS 0–2. The estimated odds of functional independence decreased by 13% for every 30 minute delay from emergency department (ED) arrival to imaging time and by 7% from ED arrival to the end of EVT in the entire cohort. Also, the estimated odds of functional independence decreased by 33% for every 30 minute delay in the interval from arterial puncture to end of EVT, 16% in the interval from arrival in ED to end of EVT and 6% in the interval from stroke onset to end of EVT among patients who had a wake-up stroke.Conclusion:Faster workflow from ED arrival to end of EVT is associated with improved functional independence among stroke patients treated in the late window.
Examining Crime-Specific and Crime-General Theories of Crime Causation at Place: The Case of Property and Violent Crime on Street Segments in Tel Aviv-Yafo
Authors: Amram Shai , Weisburd David , Shay Maor 
Published: April 2024

AbstractWe use data on street segments in Tel Aviv-Yafo to examine whether general or specific crime factors are key to understanding crime rates on street segments. We pose two questions. (1) What causal factors explain the property and violent crimes at the same locations? (2) What are the differences and similarities between the risk factors of the two crime types? Our study capitalizes on data drawn from the Israeli Central Bureau of Statistics (CBS) to identify social and opportunity data at the street segment level. The dependent variable is the average counts of violent and property crimes in Tel Aviv-Yafo between 2010 and 2014. Zero-inflated negative binomial (ZINB) regression explains violent and property crime variations. While many of the significant factors that explain crime are similar between the two crime types, there are also distinct criminogenic factors predicting violent and property crime. Overall, our results support the position of common or general crime causes at places, but at the same time, they suggest the importance of understanding specific causes for specific crime types.
Internal and External Crime Hot Spots: From Neural to Micro-Geographical Networks
Authors: Leshem Rotem 
Published: April 2024

AbstractAntisocial behaviour arises from a complex interplay of innate and environmental factors, with the brain’s adaptability to shifting environmental demands playing a pivotal role. An important but scantly studied environmental factor – micro-geographic hot spots of crime – covers a broad array of problems that produce frequent triggers for antisocial behaviour. Despite the established influence of neural substrates and various environmental factors on antisocial behaviour, the impact of residing in high-risk, violent crime hot spots in Israel, as well as other global locales, remains understudied. This paper aims to elucidate the intricate interplay between neurobiological mechanisms and crime hot spots in the context of antisocial behaviour. Its objectives are twofold: first, to acquaint researchers with the existing literature on the subject; and second, to catalyse further research and robust discourse in this domain. The article commences by reviewing the behavioural manifestations of antisocial tendencies within the framework of crime hot spots. Subsequently, it delves into the influence of crime hot spots on neurocognitive substrates, particularly emphasizing their impact on developmental trajectories associated with antisocial tendencies and the expression of antisocial behaviours. In closing, the paper offers implications and conclusions pertinent to crime hot spots in Israel.