bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early teleostean basal ganglia development visualized by Zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression
Authors: Mueller Thomas , Wullimann Mario F. , Guo Su 
Published: January 2008

AbstractWe examined the brain expression patterns of zebrafish genes Lhx6, Lhx7, Dlx2a, GAD67, and Tbr2/eomesa; except for GAD67, expression domains are restricted to the forebrain. In particular, a distribution of transcripts in the early zebrafish telencephalon comparable to that of tetrapods is revealed. Expression domains of Lhx6 and Lhx7 are restricted to a ventral subdivision (Sdv) of the precommissural dorsal subpallium, interpreted here as the homologue of the mammalian medial ganglionic eminence (the adult pallidum in mammals). In contrast, there is no such expression in the dorsal subdivision (Sdd) of the dorsal subpallium, interpreted here as the homologue of the mammalian lateral ganglionic eminence (the adult caudatoputamen in mammals). The Lhx6 and Lhx7 genes are furthermore expressed in the zebrafish ventral subpallium (Sv, septum), and in the supra‐/postcommissurally lying posterior subdivision of the dorsal subpallium (Sdp; possible homologue of the subpallial amygdala). Also in support of this comparative interpretation, Dlx2a is generally expressed in all of the subpallium, including the ventricular zones of (all three subvidisions of) the dorsal as well as of the ventral subpallium. In contrast, Tbr2 is expressed in all of the zebrafish pallium and in a restricted zone of the ventral subpallium, comparable to the known restricted septal expression in mammals. The telencephalic expression of GAD67 largely coincides with that of Dlx2a. However, GAD67‐positive cells migrate (radially) into postmitotic zones of the peripheral subpallium (as does Dlx2a and Lhx6) as well as (tangentially) into pallial zones (as does Dlx2a, but not Lhx6). J. Comp. Neurol. 507:1245–1257, 2008. © 2008 Wiley‐Liss, Inc.
Diagnostic pitfalls in fine needle aspiration biopsy of the spleen
Authors: Friedlander Maria A. , Wei Xiao‐Jun , Iyengar Pratibha , Moreira Andre L. 
Published: January 2008

AbstractFine needle aspiration (FNA) of the spleen is rarely performed, due to fear of procedure complications. The objective of this study is to review the cytologic diagnoses of aspiration biopsy of the spleen performed in a cancer center.Archival material (9‐year period) was reviewed and correlated with histologic and ancillary test results, when available.Forty‐one splenic FNA specimens were identified. There were no reported procedure complications. Nineteen cases were diagnosed as malignant. Of these, 11 were lymphomas. Nineteen cases were diagnosed as benign. There was one false‐negative case and four false‐positive cases. Primary splenic neoplasms were rare and misinterpreted as malignant.It is important to be familiar with the normal cytology of this uncommonly aspirated organ in order to successfully identify neoplastic and malignant processes. The use of ancillary studies is important in the definitive classification of benign and malignant splenic lesions. Diagn. Cytopathol. 2008;36:69–75. © 2008 Wiley‐Liss, Inc.
Critical thresholds, evaluation and regional development
Authors: ten Brink Patrick , Miller Clare , Kettunen Marianne , Ramsak Klavdije , Farmer Andrew , Hjerp Peter , Anderson Jason 
Published: January 2008

AbstractThis paper is part of the Special Issue of European Environment devoted to the outputs of the EU SRDTOOLS project, which developed and applied a new model of regional sustainable development evaluation. This paper introduces as an evaluation criterion the idea of critical thresholds, which up to now have not been sufficiently integrated into thinking and decision making in the context of regional development. Decision making explicitly or implicitly accepts trade‐offs across economic, social, human and nature domains. Some of these trade‐offs, especially when they may threaten system integrity, are not sufficiently understood. The paper discusses how critical thresholds and trends can be integrated into evaluation methods and provides some insights from practical applications. It concludes that such integration into regional planning and evaluation should support objectives for sustainable development and improve decision making and environmental governance. Copyright © 2008 John Wiley & Sons, Ltd and ERP Environment.
Adsorption of Metal Ions on an Activated Carbon/L‐Lysine Derivative Hybrid Compound
Authors: García‐Martín Javier , Godino‐Salido M. Luz , López‐Garzón Rafael , Gutiérrez‐Valero M. Dolores , Arranz‐Mascarós Paloma , Stoeckli‐Evans Helen 
Published: January 2008

AbstractThe new compound Nϵ‐(4‐amino‐1,6‐dihydro‐1‐methyl‐5‐nitroso‐6‐oxopyrimidin‐2‐yl)‐L‐lysine (H2L) has been synthesised and its molecular structure determined by single‐crystal X‐ray diffraction methods. The Brönsted acid/base character of H2L has been determined in water in the pH range 2.5–10.0, and the nature of the observed protonation steps determined by potentiometric and spectrophotometric methods. The adsorption of H2L on a commercial activated carbon (AC) in aqueous solution is irreversible, mainly due to the electronic behaviour of the π system of the pyrimidine moiety. The adsorption of H2L on the AC provides a route to develop NH3+‐CHR‐COO–‐type functions on the AC surface, thereby yielding a new hybrid material with an enhanced adsorption capacity for metal ions in aqueous solution. The adsorption of NiII, CuII, ZnII and CdII ions on the functionalised AC has been studied and the results analysed on the basis of the reactivity data for several pyrimidine ligand/metal ion systems. The results, which show an enhancement of the adsorption capacity of the new material with respect to the unfunctionalised AC, are compared with analogous materials studied previously.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Immobilisation of η3‐Allyldicarbonyl Complexes of MoII with Bidentate Nitrogen Ligands within Aluminium‐Pillared Clays
Authors: Alonso João Carlos , Neves Patrícia , Silva Carlos , Valente Anabela A. , Brandão Paula , Quintal Susana , Villa de Brito Maria J. , Pinto Patrícia , Félix Vítor , Drew M. G. B. , Pires João , Carvalho Ana Paula , Calhorda Maria José , Ferreira Paula 
Published: January 2008

AbstractMolybdenum(II) complexes [MoX(CO)2(η3‐allyl)(CH3CN)2] (X = Cl or Br) were encapsulated in an aluminium‐pillared natural clay or a porous clay heterostructure and allowed to react with bidentate diimine ligands. All the materials obtained were characterised by several solid‐state techniques. Powder XRD, and 27Al and 29Si MAS NMR were used to investigate the integrity of the pillared clay during the modification treatments. 13C CP MAS NMR, FTIR, elemental analyses and low‐temperature nitrogen adsorption showed that the immobilisation of the precursor complexes was successful as well as the in situ ligand‐substitution reaction. The new complex [MoBr(CO)2(η3‐allyl)(2‐aminodipyridyl)] was characterised by single‐crystal X‐ray diffraction and spectroscopic techniques, and NMR studies were used to investigate its fluxional behaviour in solution. The prepared materials are active for the oxidation of cis‐cyclooctene using tert‐butyl hydroperoxide as oxidant, though the activity of the isolated complexes is higher. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Application of New Organic Fuels in the Direct MgAl2O4 Combustion Synthesis
Authors: Ianoş Robert , Lazău Ioan , Păcurariu Cornelia , Barvinschi Paul 
Published: January 2008

AbstractThe paper presents a new version of MgAl2O4 solution‐combustion synthesis, based on the individual reactivity of Mg(NO3)2 and Al(NO3)3 with respect to various fuels. Beside the traditionally used fuels (urea, glycine, β‐alanine), new organic reducing agents [monoethanolamine, triethanolamine, tris(hydroxymethyl)aminomethane and triethylenetetramine] have also been used. The study of the individual reactivities of Mg(NO3)2 and Al(NO3)3 with respect to each of the previously mentioned fuels suggested that there is a predilection of the two metal nitrates for certain fuels: urea is the optimum fuel for Al(NO3)3, whereas monoethanolamine represents the most suitable fuel for Mg(NO3)2. It has been shown by X‐ray diffraction and thermal analysis that the use of a single fuel in the MgAl2O4 low‐temperature combustion synthesis leads to the formation of an amorphous powder. In this case, the formation of pure crystalline MgAl2O4 requires a subsequent thermal treatment at 900 °C with 1 h soaking time. On the other hand, the use of fuel mixtures containing urea and monoethanolamine or urea and β‐alanine proved to be the rational solution for the direct formation of MgAl2O4. It has been shown that, by using the above‐mentioned fuel mixtures, one can obtain pure nanocrystalline MgAl2O4 straight from the combustion reaction, no additional calcination being necessary. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis, Structure, and Catalytic Activity of TiIV and ZrIV Complexes Derived from (R)‐2,2′‐Diamino‐1,1′‐binaphthyl‐Based N4‐Donor Ligands
Authors: Xiang Li , Song Haibin , Zi Guofu 
Published: January 2008

AbstractReaction of (R)‐bis(pyrrol‐2‐ylmethyleneamino)‐1,1′‐binaphthyl (1H2) or (R)‐N,N′‐bis(pyridin‐2‐ylmethyl)‐1,1′‐binaphthyl‐2,2′‐diamine (2H2) with Zr(NMe2)4 (1 equiv.) gives chiral zirconium amides 1‐Zr(NMe2)2·C7H8 (4·C7H8) or 2‐Zr(NMe2)2 (6) in good yields, respectively. Under similar conditions, 1H2 reacts with Ti(NMe2)4 (1 equiv.) to give chiral titanium amide 1‐Ti(NMe2)2·C6H6 (3·C6H6), whereas treatment of 2H2 with Ti(NMe2)4 (1 equiv.) leads to the isolation of bis(ligated) product (2)2‐Ti·C7H8 (5·C7H8) in 74 % yield. All complexes were characterized by various spectroscopic techniques, elemental analysis, and X‐ray diffraction analysis. Zirconium amides 4 and 6 are active catalysts for the asymmetric hydroamination/cyclization of aminoalkenes, and cyclic amines were obtained in good‐to‐excellent yields with moderate ee values (up to 59 %); titanium amides 2 and 5 were not active under the reaction conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Oxidative Ligand Rearrangement Due to Incipient Aminyl Radicals in the Oxidation of Iron(II) Species with Dioxygen
Authors: Çelenligil‐Çetin Remle , Paraskevopoulou Patrina , Dinda Rupam , Lalioti Nikolia , Sanakis Yiannis , Rawashdeh Abdel Monem , Staples Richard J. , Sinn Ekkehard , Stavropoulos Pericles 
Published: January 2008

AbstractThe ferrous complex [(L1)FeII–THF]–, featuring the trisamido‐amine ligand [(RNC6H4)3N]3–, where R is the electron‐rich 4‐tBu‐Ph moiety, can undergo a one‐electron oxidation by dioxygen to afford the corresponding [(L1)FeIII–OH]– complex, and a parallel two‐electron oxidation to generate the antiferromagnetically coupled diferric μ‐oxo compound [(L1re–1)Fe–O–Fe(L1re–1)]. The latter compound possesses a ligand that exhibits oxidative rearrangement and retention of the oxidation equivalent in a o‐diiminobenzosemiquinato moiety as a π radical. Ligand oxidation is perceived to initiate at an amido residue leading to formation of an electrophilic, metal‐bould aminyl radical that undergoes an 1,4‐(N‐to‐N) aryl migration reaction.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Identification of the Eight‐Membered Heterocycles Hicksoanes A–C from the Gorgonian Subergorgia hicksoni
Authors: Řezanka Tomáš , Hanuš Lumír O. , Dembitsky Valery M. , Sigler Karel 
Published: January 2008

AbstractNovel eight‐membered heterocycles, named hicksoanes A–C, were isolated from the gorgonian Subergorgia hicksoni. Their structures, including the absolute configuration of all three stereocenters, were determined by means of extensive spectroscopic data. Hicksoanes have a unique structure containing a triazocane cycle, which is substituted by isoleucine and tryptophan moieties. Hicksoanes A–C showed antifeeding activity against goldfish at natural concentration (≈10 μg mL–1).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Efficient Two‐Step Synthesis of Face‐to‐Face meso‐Substituted Bis(corrole) Dyads
Authors: El Ojaimi Maya , Gros Claude P. , Barbe Jean‐Michel 
Published: January 2008

AbstractThe synthesis of face‐to‐face meso‐substituted bis(corrole) systems was revisited. By using a new synthetic pathway, the reaction was generalized to any type of linker and the yield was considerably increased. The dyads were obtained in yields up to 20 % from a dialdehyde linker and dipyrromethane in a one‐step reaction. The best reaction conditions required a decreased amount of TFA catalyst (1.4 equiv.) and a large excess of dipyrromethane (up to 8 equiv). Under these conditions, four bis(corrole)s linked by 2,2′‐diphenyl ether, 9,9‐dimethylxanthene, anthracene, and dibenzofuran spacers were synthesized.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Rigid C3‐Symmetric Scaffolds Based on Adamantane
Authors: Pannier Nadine , Maison Wolfgang 
Published: January 2008

AbstractEfficient syntheses of rigid C3‐symmetric scaffolds based on adamantane are described. The scaffolds are available in multigram quantities and have been designed for conjugation to various natural products such as carbohydrates and peptides. They are thus valuable for the construction of strictly defined molecular architectures with threefoldgeometry for applications in bioorganic chemistry, catalysis or material science. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Core‐Extended Terrylenetetracarboxdiimides – Novel, Strongly Red Fluorescent Broadband Absorbers
Authors: Langhals Heinz , Poxleitner Simon 
Published: January 2008

AbstractStrongly red fluorescent and broadband absorbing benzoterrylenehexacarboxtriimide (8) and yellow fluorescent dibenzoterryleneoctacarboxtetraimide (9) were prepared by the Diels–Alder reaction of readily soluble terrylenetetracarboxdiimides and subsequent condensation with primary amines. Applications such as for solar energy systems are discussed.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Resolution of Racemic N‐Benzyl α‐Amino Acids by Liquid‐Liquid Extraction: A Practical Method Using a Lipophilic Chiral Cobalt(III) Salen Complex and Mechanistic Studies
Authors: Dzygiel Pawel , Reeve Toby B. , Piarulli Umberto , Krupicka Martin , Tvaroska Igor , Gennari Cesare 
Published: January 2008

AbstractThe efficient resolution of racemic N‐benzyl α‐amino acids (N‐Bn‐AA) has been achieved by a liquid‐liquid extraction process using the lipophilic chiral salen–cobalt(III) complex [CoIII(3)(OAc)]. As a result of the resolution by extraction, one enantiomer (S) of the N‐benzyl α‐amino acid predominated in the aqueous phase, while the other enantiomer (R) was driven into the organic phase by complexation to cobalt. The complexed amino acid (R) was then quantitatively released by a reductive (CoIII → CoII) counter‐extraction with aqueous sodium dithionite or L‐ascorbic acid in methanol. Thereductive cleavage allowed to recover the [CoII(3)] complex in good yield, which could be easily re‐oxidized to[CoIII(3)(OAc)] with air/AcOH and reused with essentially no loss of reactivity and selectivity. Investigation on the nitrogen substitution indicates that the presence of a single benzyl group on the amino acid nitrogen is important to obtain high enantioselectivity in the extraction process. The kinetic vs. thermodynamic nature of the resolution process was also investigated with an enantiomeric exchange experiment, which shows that the liquid‐liquid extraction with [CoIII(3)(OAc)] is an equilibrium process operating under thermodynamic control. In the absence of a suitable crystal structure of the [CoIII(3)(N‐Bn‐AA)] complexes, computational and spectroscopic studies were used to investigate how the N‐benzyl α‐amino acids are accommodated in the “binding pocket” of the chiral cobalt complex. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Shape optimization using adjoint variable method for reducing drag in Stokes flow
Authors: Shinohara Kazunori , Okuda Hiroshi , Ito Satoshi , Nakajima Norihiro , Ida Masato 
Published: January 2008

AbstractTo minimize the drag of a 3D object placed under Stokes flow, an adjoint variable method based on the variational principle was formulated and applied to the finite element method. The optimality condition of the present method consists of the state equations, the adjoint equations, and the sensitivity equations. As related techniques, a smoothing method for the surface mesh, a method to guarantee the constant volume condition, and a mesh relocation technique using the biharmonic equation were developed. These techniques are crucial in realizing shape optimization. To overcome such difficulties as heavy computational burden and large memory requirements, the present system was implemented with the data compression technology supplied with the parallel software library HEC‐MW. Also, by utilizing HEC‐MW, the program was efficiently parallelized, and the number of program lines was dramatically reduced. By the proposed shape optimization method, the drag on a cylinder was reduced by about 25% under a Stokes flow condition. Copyright © 2008 John Wiley & Sons, Ltd.
Finite element approximation of the modified Boussinesq equations using a stabilized formulation
Authors: Codina Ramon , González‐Ondina José M. , Díaz‐Hernández Gabriel , Principe Javier 
Published: January 2008

AbstractIn this work, we present a finite element model to approximate the modified Boussinesq equations. The objective is to deal with the major problem associated with this system of equations, namely, the need to use stable velocity‐depth interpolations, which can be overcome by the use of a stabilization technique. The one described in this paper is based on the splitting of the unknowns into their finite element component and the remainder, which we call the subgrid scale. We also discuss the treatment of high‐order derivatives of the mathematical model and describe the time integration scheme. Copyright © 2008 John Wiley & Sons, Ltd.
Two‐temperature Euler equations for a plasma with slowing down of suprathermal particles
Authors: Sentis R. , Chaland F. 
Published: January 2008

AbstractIn the hot plasma simulations when the main flow is modeled by two‐temperature Euler equations, it is often useful to deal with slowing down of suprathermal particles created by fusion. Then a kinetic equation has to be addressed for these particles. We focus in this paper on the coupling between the fluid model and the kinetic equation; specially details for a coherent treatment of the electrostatic field are given. We emphasize some details of the numerical simulations and we give numerical results. Copyright © 2008 John Wiley & Sons, Ltd.
A framework for discontinuous fluctuation distribution
Authors: Hubbard M. E. 
Published: January 2008

AbstractThis paper describes a new numerical scheme for the approximation of systems of hyperbolic conservation laws. It generalizes the fluctuation distribution framework by allowing the underlying representation of the solution to be discontinuous. Steady‐state numerical results are presented for the Euler equations of gasdynamics. Copyright © 2008 John Wiley & Sons, Ltd.
CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: Evidence for a common genetic association
Authors: Bell Diana , Luna Mario A. , Weber Randal S. , Kaye Frederic J. , El‐Naggar Adel K. 
Published: January 2008

AbstractTranslocations and gene fusions have an important early role in tumorigenesis. The t(11;19) translocation and its CRTC1/MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors. To determine whether Warthin's tumor and mucoepidermoid carcinoma are genetically related, we used reverse transcriptase‐polymerase chain reaction and DNA sequencing to analyze microdissected components of three tumors consisting of Warthin's tumor and mucoepidermoid carcinoma. We also investigated a metastatic melanoma to Warthin's tumor and a Warthin's carcinoma of the parotid gland for comparison. The fusion transcript was identified in both Warthin's tumor and matching mucoepidermoid carcinoma components of all three tumors, in the Warthin's carcinoma, and in the Warthin's tumor component but not in the metastatic melanoma. The results provide evidence for a link between the t(11;19) fusion gene and the development of a subset of Warthin's tumors with concurrent mucoepidermoid carcinoma and possible malignant transformation to Warthin's carcinoma. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045‐2257/suppmat. © 2008 Wiley‐Liss, Inc.
Non‐Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene
Authors: Pineda M. , Castellsagué E. , Musulén E. , Llort G. , Frebourg T. , Baert‐Desurmont S. , González S. , Capellá G. , Blanco I. 
Published: January 2008

AbstractHereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal disorder caused by mutations in DNA mismatch repair (MMR) genes. Tumors of the HNPCC‐spectrum are associated with microsatellite instability (MSI) and loss of MMR protein expression. Lymphomas are not considered to be HNPCC‐related tumors. We report and analyze a case of an HNPCC patient with three colorectal cancers and a B‐cell non‐Hodgkin lymphoma. Quantitative multiplex PCR of short fluorescent fragments detected a novel MSH2 rearrangement involving exons 9 and 10, which proved to be the pathogenic cause of the disease in the family. Tumor tissues including the lymphoma showed MSI and loss of MSH2 expression. Multiplex ligation‐dependent probe amplification analysis revealed a somatic loss of the wild‐type MSH2 allele in the lymphoma. These results support the fact that the total loss of a MMR gene can lead to lymphomagenesis, as seen in biallelic MMR‐deficient families and knockout mice. Moreover, this is the first report of a B‐cell non‐Hodgkin lymphoma with a loss of the MSH2 protein expression, linked to a heterozygous germline MSH2 mutation in an HNPCC family. © 2008 Wiley‐Liss, Inc.
Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia
Authors: Horsley Sharon W. , Colman Susan , McKinley Mark , Bateman Caroline M. , Jenney Meriel , Chaplin Tracy , Young Bryan D. , Greaves Mel , Kearney Lyndal 
Published: January 2008

AbstractIn a small fraction (∼2%) of cases of childhood acute lymphoblastic leukemia (ALL) clinical presentation of leukemia is preceded, some 2–9 months earlier, by a transient, remitting phase of nonclassical aplastic anemia, usually in connection with infection. The potential “preleukemic” nature of this prodromal phase has not been fully explored. We have retrospectively analyzed the blood and bone marrow of a child who presented with aplastic anemia 9 months before the development of ETV6‐RUNX1 fusion gene positive ALL. High resolution SNP genotyping arrays identified 11 regions of loss of heterozygosity, with and without concurrent copy number changes, at the presentation of ALL. In all cases of copy number change, the deletion or gain identified by single nucleotide polymorphism (SNP) analysis was confirmed in the ALL blasts by FISH. Retrospective analysis of aplastic phase bone marrow showed that the ETV6‐RUNX1 fusion was present along with all of the additional genetic changes assessed, albeit subclonal to ETV6‐RUNX1. These data identify for the first time the leukemic genotype of an aplasia preceding clinical ALL and indicate that multiple secondary genetic abnormalities can contribute to a dominant subclone several months before a diagnosis of ALL. These data have implications for the biology of ALL and for management of similar patients. © 2008 Wiley‐Liss, Inc.