bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reshaping Li–Mg hybrid batteries: Epitaxial electrodeposition and spatial confinement on MgMOF substrates via the lattice‐matching strategy
Authors: Wang Yongqin , Cheng Fulin , Ji Jiawen , Cai Chenyang , Fu Yu 
Published: March 2024

AbstractThe emergence of Li–Mg hybrid batteries has been receiving attention, owing to their enhanced electrochemical kinetics and reduced overpotential. Nevertheless, the persistent challenge of uneven Mg electrodeposition remains a significant impediment to their practical integration. Herein, we developed an ingenious approach that centered around epitaxial electrocrystallization and meticulously controlled growth of magnesium crystals on a specialized MgMOF substrate. The chosen MgMOF substrate demonstrated a robust affinity for magnesium and showed minimal lattice misfit with Mg, establishing the crucial prerequisites for successful heteroepitaxial electrocrystallization. Moreover, the incorporation of periodic electric fields and successive nanochannels within the MgMOF structure created a spatially confined environment that considerably promoted uniform magnesium nucleation at the molecular scale. Taking inspiration from the “blockchain” concept prevalent in the realm of big data, we seamlessly integrated a conductive polypyrrole framework, acting as a connecting “chain,” to interlink the “blocks” comprising the MgMOF cavities. This innovative design significantly amplified charge‐transfer efficiency, thereby increasing overall electrochemical kinetics. The resulting architecture (MgMOF@PPy@CC) served as an exceptional host for heteroepitaxial Mg electrodeposition, showcasing remarkable electrostripping/plating kinetics and excellent cycling performance. Surprisingly, a symmetrical cell incorporating the MgMOF@PPy@CC electrode demonstrated impressive stability even under ultrahigh current density conditions (10 mA cm–2), maintaining operation for an extended 1200 h, surpassing previously reported benchmarks. Significantly, on coupling the MgMOF@PPy@CC anode with a Mo6S8 cathode, the assembled battery showed an extended lifespan of 10,000 cycles at 70 C, with an outstanding capacity retention of 96.23%. This study provides a fresh perspective on the rational design of epitaxial electrocrystallization driven by metal–organic framework (MOF) substrates, paving the way toward the advancement of cutting‐edge batteries.
20π‐Electron Antiaromatic Benziphthalocyanines with Absorption Reaching the Near‐Infrared‐II Region
Authors: Yanagi Shunsuke , Takayama Orie , Toriumi Naoyuki , Muranaka Atsuya , Hashizume Daisuke , Uchiyama Masanobu 
Published: March 2024

AbstractAlthough second near‐infrared (NIR‐II, 1000–1500 nm) light has attracted considerable attention, especially for life sciences applications, the development of organic dyes with NIR‐II absorption remains a formidable challenge. Herein we report the design, synthesis, and electronic properties of 20π‐electron antiaromatic benziphthalocyanines (BPcs) that exhibit intense absorption bands in the NIR region. The strong, low‐energy absorption of the antiaromatic BPcs is attributed to electric‐dipole‐allowed HOMO‐LUMO transitions with narrow band gaps, enabled by the reduced structural symmetry of BPc compared with regular porphyrins and phthalocyanines. The combination of peripheral substituents and a central metal decreases the HOMO‐LUMO energy gaps, leading to the extension of the absorption bands into the NIR‐II region (reaching 1100 nm) under reductive conditions.
Metal‐Free Selective Synthesis of α,β‐Unsaturated Aldehydes from Alkenes and Formaldehyde Catalyzed by Dimethylamine
Authors: Peng Gongming , Ullah Naseeb , Streiff Stéphane , De Oliveira Vigier Karine , Pera‐Titus Marc , Wischert Raphael , Jérôme François 
Published: March 2024

Abstractα,β‐Unsaturated aldehydes are important building blocks for the synthesis of a wide range of chemicals, including polymers. The synthesis of these molecules from cheap feedstocks such as alkenes remains a scientific challenge, mainly due to the low reactivity of alkenes. Here we report a selective and metal‐free access to α,β‐unsaturated aldehydes from alkenes with formaldehyde. This reaction is catalyzed by dimethylamine and affords α,β‐unsaturated aldehydes in yields of up to 80 %. By combining Density Functional Theory (DFT) calculations and experiments, we elucidate the reaction mechanism which is based on a cascade of hydride transfer, hydrolysis and aldolization reactions. The reaction can be performed under very mild conditions (30–50 °C), in a theoretically 100 % carbon‐economical fashion, with water as the only by‐product. The reaction was successfully applied to non‐activated linear 1‐alkenes, thus opening an access to industrially relevant α,β‐unsaturated aldehydes from cheap and widely abundant chemicals at large scale.
Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid‐Controlled Divergent Chemoselectivity†
Authors: Chen Ling‐Ling , Cao Ren‐Fei , Ke Hua , Chen Zhi‐Min 
Published: March 2024

Comprehensive SummaryLewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first time. Various selenium‐containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z selectivities. As the substrates were 1‐ethynyl naphthol derivatives, linear selenium‐containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive; in contrast, cyclic selenium‐containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.
Ru(II)‐Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes
Authors: Luo Quan‐Jian , Wang Han‐Chi , Zhang Jing , Li Jin‐Heng , Sun Bo 
Published: March 2024

Comprehensive SummaryA new, selective Ru(II)‐catalyzed alkynylation reaction of isoquinolones, quinazolones and phthalazinones with readily available bromoalkynes has been developed. This reaction enables the selective construction of a new C(sp2)‐C(sp) bond through C—H activation and C—Br functionalization, and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone, quinazolone and phthalazinone derivatives with a wide substrate scope and high selectivity.
Knowledge, attitude, and practice toward postoperative self‐management among patients after percutaneous coronary intervention: A structural equation modeling analysis
Authors: Lei Hailing , Zhu Lin , Zhang Xin 
Published: March 2024

AbstractObjectiveThe knowledge, attitude, and practice (KAP) toward post‐percutaneous coronary intervention (PCI) self‐management among Chinese patients remains unknown. This study investigated the KAP toward postoperative self‐management among patients after PCI.HypothesisPatients exhibit poor knowledge, attitudes, and practices regarding post‐PCI self‐management, requiring enhanced education strategies.MethodsThis cross‐sectional study recruited patients after PCI at Jishuitan Hospital, Beijing, between November 2022 and May 2023. Inclusion criteria comprised patients 1–3 months post‐PCI, those capable of self‐care, and those willingly participating. The questionnaire (49 items) was designed with reference to current guidelines (the Cronbach α = .829). The final questionnaire included four dimensions with 49 items. The Pearson correlation analysis and structural equation modeling (SEM) were used to determine the relationship among knowledge, attitude, and practice.ResultsA total of 476 valid questionnaires were included. The knowledge, attitude, and practice scores were 8.24 ± 2.78 (possible range: 0–12), 21.61 ± 3.15 (possible range: 9–45), and 32.62 ± 3.75 (possible range: 10–50). The Pearson correlation analysis showed only knowledge scores were correlated with the attitude scores (r = .446, p < .001). The SEM showed that knowledge directly affects attitude (β = .616, p < .001) but had no influence on practice (β = .119, p = .155); attitude had no influence on practice (β = .015, p = .809).ConclusionThis study indicated that patients had poor knowledge, unfavorable attitudes, and unsatisfied practice toward post‐PCI self‐management. Strengthening patient health education through diverse approaches is imperative.
Illuminating the terminal nerve: Uncovering the link between GnRH‐1 neuron and olfactory development
Authors: Amato Enrico , Taroc Ed Zandro M. , Forni Paolo E. 
Published: March 2024

AbstractDuring embryonic development, the olfactory placode (OP) generates migratory neurons, including olfactory pioneer neurons, cells of the terminal nerve (TN), gonadotropin‐releasing hormone‐1 (GnRH‐1) neurons, and other uncharacterized neurons. Pioneer neurons from the OP induce olfactory bulb (OB) morphogenesis. In mice, GnRH‐1 neurons appear in the olfactory system around mid‐gestation and migrate via the TN axons to different brain regions. The GnRH‐1 neurons are crucial in controlling the hypothalamic‐pituitary‐gonadal axis. Kallmann syndrome is characterized by impaired olfactory system development, defective OBs, secretion of GnRH‐1, and infertility. The precise mechanistic link between the olfactory system and GnRH‐1 development remains unclear. Studies in humans and mice highlight the importance of the prokineticin‐2/prokineticin‐receptor‐2 (Prokr2) signaling pathway in OB morphogenesis and GnRH‐1 neuronal migration. Prokr2 loss‐of‐function mutations can cause Kallmann syndrome (KS), and hence the Prokr2 signaling pathway represents a unique model to decipher the olfactory/GnRH‐1 connection. We discovered that Prokr2 is expressed in the TN neurons during the critical period of GnRH‐1 neuron formation, migration, and induction of OB morphogenesis. Single‐cell RNA sequencing identified that the TN is formed by neurons distinct from the olfactory neurons. The TN neurons express multiple genes associated with KS. Our study suggests that the aberrant development of pioneer/TN neurons might cause the KS spectrum.
Correlation between morphological parameters and dosimetric parameters of the heart and spinal cord in the intermediate‐ and advanced‐stage esophageal cancer
Authors: Zhao Wenjuan , Lan Linzhen , Xu Bichun , Chen Di , Zeng Yusha , Guo Feibao , Zhang Huojun 
Published: March 2024

AbstractBackgroundRadiation therapy plays a pivotal role as the primary adjuvant treatment for esophageal cancer (EPC), emphasizing the critical importance of carefully balancing radiation doses to the target area and organs at risk in the radiotherapeutic management of esophageal cancer.AimsThis study aimed to explore the correlation between morphological parameters and dosimetric parameters of the heart and spinal cord in intermediate‐ and advanced‐stage esophagus cancer to provide a reference for clinical treatment.Methods and resultsA total of 105 patients with intermediate‐ and advanced‐stage EPC, who received treatment in our hospital from 2019 to 2021, were included. The morphological parameters were calculated by imaging. Intensity‐modulated radiation therapy plan was executed at Raystation4.7. The PTV‐G stood for the externally expanded planning target volume (PTV) of the gross tumor volume (GTV) and PTV‐C for the externally expanded volume of the clinical target volume (CTV). The prescription dose of PTV‐G and PTV‐C was set as 60Gy/30F and 54Gy/30F, respectively. The linear regression model was used to analyze the correlation between morphologic parameters of EPC and dosimetric parameters of the heart and spinal cord. In 105 cases, the total lung length was correlated with the spinal cord maximum dose (D2). The heart mean doses (Dmean) and heart V40 (the relative volume that receives 40 Gy or more) was correlated with PTV‐G volume, PTV‐G length; In middle‐ and upper‐segment EPC cases, only the total lung volume was correlated with the spinal cord Dmean, spinal cord D2, heart Dmean, and heart V40; In middle‐stage EPC cases, the heart Dmean was correlated with the PTV‐G volume, PTV‐G length. The total lung length was correlated with the spinal cord D2; In middle‐ and lower‐segment EPC, only the PTV‐G volume and PTV‐G length were correlated with the heart Dmean. All the aforementioned values were statistically significant.ConclusionsCombined with the unsegmented tumor and different locations, the organ at risk dose was comprehensively considered.
Covalent Tethering of Cobalt Porphyrins on Phenolic Resins for Electrocatalytic Oxygen Reduction and Evolution Reactions
Authors: Kong Jiafan , Qin Haonan , Yang Luna , Zhang Jieling , Peng Yuxin , Gao Yimei , Wu Yizhen , Nam Wonwoo , Cao Rui 
Published: March 2024

AbstractThe front cover artwork is provided by Rui Cao's group at Shaanxi Normal University. The image shows the design of Co‐porphyrin‐engineered phenolic resins with intramolecular phenolic hydroxyl groups to facilitate proton and electron transfers for efficient oxygen electrocatalysis, which is bioinspired by cytochrome c oxidases, and shows the excellent performance of Zn‐air batteries assembled with the hybrid material. Read the full text of the Research Article at 10.1002/cphc.202400017.
Graft‐versus‐leukaemia immunity is retained following treatment with post‐transplant cyclophosphamide alone or combined with tocilizumab in humanised mice
Authors: Sligar Chloe , Reilly Ellie , Cuthbertson Peter , Vine Kara L , Bird Katrina M , Elhage Amal , Alexander Stephen I , Sluyter Ronald , Watson Debbie 
Published: March 2024

AbstractObjectivesDonor haematopoietic stem cell transplantation treats leukaemia by inducing graft‐versus‐leukaemia (GVL) immunity. However, this benefit is often mitigated by graft‐versus‐host disease (GVHD), which is reduced by post‐transplant cyclophosphamide (PTCy) alone or combined with tocilizumab (TOC) in humanised mice. This study established a preclinical humanised mouse model of GVL and investigated whether PTCy alone or combined with TOC impacts GVL immunity.MethodsNOD‐scid‐IL2Rγnull mice were injected with 2 × 107 human peripheral blood mononuclear cells (hPBMCs) on day 0 and with 1 × 106 THP‐1 acute myeloid leukaemia cells on day 14. In subsequent experiments, mice were also injected with PTCy (33 mg kg−1) or Dulbecco's phosphate buffered saline (PBS) on days 3 and 4, alone or combined with TOC or control antibody (25 mg kg−1) twice weekly for 28 days. Clinical signs of disease were monitored until day 42.ResultsMice with hPBMCs from three different donors and THP‐1 cells showed similar survival, clinical score and weight loss. hCD33+ leukaemia cells were minimal in mice reconstituted with hPBMCs from two donors but present in mice with hPBMCs from a third donor, suggesting donor‐specific GVL responses. hPBMC‐injected mice treated with PTCy alone or combined with TOC (PTCy + TOC) demonstrated prolonged survival compared to control mice. PTCy alone and PTCy + TOC‐treated mice with hPBMCs showed minimal hepatic hCD33+ leukaemia cells, indicating sustained GVL immunity. Further, the combination of PTCy + TOC reduced histological damage in the lung and liver.ConclusionCollectively, this research demonstrates that PTCy alone or combined with TOC impairs GVHD without compromising GVL immunity.
Optimization strategies and advances in the research and development of AAV‐based gene therapy to deliver large transgenes
Authors: Kolesnik Valeria V. , Nurtdinov Ruslan F. , Oloruntimehin Ezekiel Sola , Karabelsky Alexander V. , Malogolovkin Alexander S. 
Published: March 2024

AbstractAdeno‐associated virus (AAV)‐based therapies are recognized as one of the most potent next‐generation treatments for inherited and genetic diseases. However, several biological and technological aspects of AAV vectors remain a critical issue for their widespread clinical application. Among them, the limited capacity of the AAV genome significantly hinders the development of AAV‐based gene therapy. In this context, genetically modified transgenes compatible with AAV are opening up new opportunities for unlimited gene therapies for many genetic disorders. Recent advances in de novo protein design and remodelling are paving the way for new, more efficient and targeted gene therapeutics. Using computational and genetic tools, AAV expression cassette and transgenic DNA can be split, miniaturized, shuffled or created from scratch to mediate efficient gene transfer into targeted cells. In this review, we highlight recent advances in AAV‐based gene therapy with a focus on its use in translational research. We summarize recent research and development in gene therapy, with an emphasis on large transgenes (>4.8 kb) and optimizing strategies applied by biomedical companies in the research pipeline. We critically discuss the prospects for AAV‐based treatment and some emerging challenges. We anticipate that the continued development of novel computational tools will lead to rapid advances in basic gene therapy research and translational studies.
Relay node selection scheme and deep sleep period for power management in energy‐harvesting wireless sensor networks
Authors: Bengheni Abdelmalek 
Published: March 2024

SummaryThis paper presents Relay node selection scheme and Deep sleep period for power management in Energy Harvesting Wireless Sensor Networks (RD‐EHWSN), a new energy‐saving scheme founded on asynchronous duty cycling. RD‐EHWSN reduces sensor node energy consumption and guarantees equilibrium energy use between sensor nodes in WSN with the energy harvesting capacity by adjusting these sensor nodes duty cycles more drastically and deeply by according to the estimated value of its residual energy on the basis of future‐presented harvested energy, and this is done through the use of a new proposed energy threshold policy. RD‐EHWSN also grips the benefit of transmitter initiated using the low power listening (LPL) technique with short preamble messages and uses a new relay node selection procedure to achieve the load balancing in WSN. We implemented RD‐EHWSN by using OMNeT++/MiXiM. For evaluation, we compared it with PS‐EHWSN, under multiple concurrent multihop traffic flows scenarios and scenarios in which nodes can harvest different energy harvesting rate. In all experiments, RD‐EHWSN significantly outperformed the PS‐EHWSN scheme; the results of simulation demonstrate that our scheme enhances the general yielding of WSN thru lessening the energy consumption and the mean latency, as well as raising the packet delivery ratio and the throughput. Moreover, RD‐EHWSN improves the WSN lifetime and ensures it operates in good condition in the case where the energy harvesting rate is lower by comparing it with the PS‐EHWSN scheme.
Analytical investigation of CdSe/CdS/ZnSe‐based single‐core double‐shell nanotextured vertical nanopillar array antenna for broadband photodetection applications
Authors: Baruah Smriti , Borah Janmoni , Maity Santanu , Rajasekaran Subramaniam 
Published: March 2024

SummaryThe photon‐trapping nanostructures greatly contributes in minimizing the light reflectance losses occurring due to air–semiconductor refractive mismatch in photodetector devices. Here we have proposed a vertically oriented CdSe/CdS/ZnSe tri material‐based multiple core–shell nanopillar array structure to act as a light‐trapping efficient antenna for broadband photodetection applications. The nanopillar structure consist of diamond shaped nanotexturization over its three layer pillar interfaces. The proposed nanotexturization over the triple‐layered nanopillar structure would feature multiple scattering mechanisms for the trapped photons enhancing their optical path length along with the defect‐free confinement of the exciton pairs. The lattice compatibility of the CdS and ZnS shell layers forms a bridge between the lattice‐mismatched CdSe core and ZnSe shell leading towards the attainment of a reduced strain as well as high photochemical stability and photo quantum efficiency. As compared to the single‐layered CdSe/ZnSe nanotextured core–shell nanopillar structure the double‐layered nanotextured CdSe/CdS/ZnSe exhibits a high photoresponsivity of 0.425 A/W and external quantum efficiency of 0.98 is attained. The obtained results exhibit that the double‐shell layered‐based nanotextured nanopillar array structure would be a well‐competent alternative as compared to the planar counterpart for next‐generation photodetector applications.
Commentary: Can an effective end‐of‐life intervention for advanced dementia be viewed as moral?
Authors: Scheeres‐Feitsma Trijntje M. , Schaafsma Petruschka , van der Steen Jenny T. , van Delden Johannes J. M. 
Published: March 2024

AbstractWe comment on Dr. Terman's considerations on the moral justification of ceasing assisted feeding and hydration for people with advanced dementia. The core idea of his paper is that an advance directive can solve future dilemmas regarding assisted feeding. We submit that this static instrument is unfit for the complex and dynamic nature of assessing how to deal with refusals to eat, in particular for people with dementia. It overvalues the past in relation to the present situation and leaves no room for the possibility of changing wishes. Moreover, the perspectives of professional caregivers and families are not addressed because the focus is entirely on individual autonomy in early dementia. Multiple perspectives should be considered in interpreting directives and the actual situation in light of the patient's view of life in order to realistically account for what is morally justifiable in care in advanced dementia.
Fasting to stop suffering in advanced dementia
Authors: Allen William Lawrence 
Published: March 2024

AbstractMany healthcare providers think withholding food and fluids from advance dementia patients, even if those patients requested that when competent, is immoral. This means such patients suffer unnecessarily long. Patients have the ethical right when capacitated to specify that they want assistance with food and drink stopped when they have advanced dementia. Physicians should implement these patient choices when advance dementia patients can no longer feed themselves. In some states there may be legal barriers to this practice.The perpetual placement of food and drink within reach of patients who are unable to feed themselves is futile, so there is no need for it. The best way for persons concerned about suffering in advanced dementia is to add a supplement to one's advance directive specifying under what circumstances one wants food and fluids assistance stopped.
Solitary fibrous tumor of deep parotid gland preoperatively classified as salivary gland neoplasm of uncertain malignant potential by the Milan system for reporting salivary gland cytopathology: A common diagnosis for a rare entity
Authors: Gokozan Hamza Numan , Scognamiglio Theresa 
Published: March 2024

AbstractSolitary fibrous tumor (SFT) is a rare fibroblastic tumor with spindle cell morphology, which is characterized by a prominent branching vasculature and a NAB2‐STAT6 gene rearrangement. SFT may occur in any anatomical site and may involve salivary glands, including the parotid gland. We present a young female with a primary parotid SFT diagnosed as “neoplasm—Salivary gland neoplasm of uncertain malignant potential (SUMP)” per the Milan system for reporting salivary gland cytopathology by fine‐needle aspiration (FNA) with surgical pathology follow‐up. Cytomorphology of SFT is diverse and overlaps with more common entities causing a diagnostic challenge. Non‐diagnostic FNA results are not uncommon. Thankfully, the majority of SFTs involving the salivary gland can be identified as “neoplasm” on FNA. The Neoplasm‐SUMP subcategory is considered for the majority of cases, which would warrant a diagnostic excision with clear surgical margins, which is also curative in most cases. The Neoplasm‐SUMP also perfectly encompasses the neoplastic behavior of SFT, which runs on a scale from indolent to malignant.