bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Levels of the Anti-inflammatory Protein CC10 Are Associated with Improvement in Bronchial Dysplasia and Sputum Cytometric Assessment in Individuals at High Risk for Lung Cancer
Authors: Chen Jiping , Lam Stephen , Pilon Aprile , McWilliams Annette , MacAulay Calum , Szabo Eva 
Published: March 2008

AbstractPurpose: CC10, a 10-kDa anti-inflammatory protein secreted by bronchiolar Clara cells, is infrequently expressed in non–small cell lung cancer and its overexpression in non–small cell lung cancer cell lines results in a less malignant phenotype. Several lines of evidence have shown that bronchial dysplasia and sputum atypia are predictors of lung cancer. We investigated whether changes in CC10 expression correlate with regression of bronchial dysplasia and/or improvement in sputum abnormalities as measured by image cytometry.Experimental Design: High-risk smokers enrolled in a chemoprevention trial underwent serial bronchoscopies with biopsies and bronchoalveolar lavage (BAL) collection, sputum assessment by image cytometry, and blood collection. CC10 was measured by competitive ELISA in BAL and plasma. Logistic regression analyses were done to determine the associations between CC10 levels and the improvement in bronchial dysplasia and sputum cytometric assessment.Results: The net change in the BAL CC10 levels in subjects with improved bronchial lesions or improved sputum cytometry assessment was significantly higher than in those without improvement (P &lt; 0.05). The odds ratio (95% confidence interval) associated with 1-unit increase in CC10 was 2.72 (1.31-5.64) for regression of dysplastic lesions and 2.94 (1.22-7.05) for improvement in sputum cytometry assessment after multivariate adjustment. Plasma CC10 was not significantly associated with either outcome.Conclusions: Higher BAL CC10 levels are significantly correlated with regression of bronchial dysplasia and improvement in sputum cytometry assessment in smokers with high lung cancer risk. Whether CC10 levels can predict clinical outcomes among high-risk populations warrants further investigation.
Structures and Electrical Properties of β- and θ-(BTM-TTP)2SbF6
Authors: Noda Manami , Yasuda Misaki , Nakano Yoshiaki , Ito Akihiro , Fueno Hiroyuki , Tanaka Kazuyoshi , Fujiwara Hideki , Sugimoto Toyonari , Misaki Yohji 
Published: March 2008

Abstract
Two kinds of (BTM-TTP)2SbF6 salts, where BTM-TTP is 2-[4,5-bis(methylthio)-1,3-dithiol-2-ylidene]-5-(1,3-dithiol-2-ylidene)-1,3,4,6-tetrathiapentalene, have been prepared. X-ray structure analyses have revealed that needle-like and plate-like crystals have the so-called β- and θ-type arrays of the donors, respectively. The β-type salt exhibits metallic conducting behavior down to 5 K, while the θ-type salt is a semiconductor even at room temperature.
Patterning of Gold Surfaces with Hexadecanethiol by Shear Force-based Scanning Capillary Microscopy
Authors: Yamada Hiroshi , Isaka Kohei , Koike Tohru , Matsue Tomokazu 
Published: March 2008

Abstract
A shear force-based scanning capillary microscope was fabricated by contacting a glass capillary with a quartz crystal tuning fork and was used for the patterning of gold surfaces with hexadecanethiol. A micrometer-sized pattern was successfully obtained by moving the capillary, through which the hexadecanethiol solution was introduced, along the gold surface. Dotted and line patterns were observed by high-resolution scanning electrochemical microscopy using a standing approach mode in (ferrocenylmethyl)trimethylammonium (FA+) solution without destroying the morphology of the surface.
Hierarchisierte Modelle in Advanced Planning and Scheduling (APS) (Hierarchical Models in Advanced Planning and Scheduling (APS))
Authors: Baumann Michael , Dimitrov Todor 
Published: March 2008

Neben der Vereinfachung von Planungsobjekten wie den Prozessen oder Ressourcen kann die Hierarchisierung dieser Planungsobjekte zu einer leichter beherrschbaren Modellierung führen. Ansätze stellen dabei das Ausschneiden irrelevanter Planungsobjekte oder deren ‘ünstliche’ Gruppierung dar. Durch die Anwendung dieser Ansätze wird eine schnelle und präzise Lieferterminermittlung ermöglicht und andererseits können langfristige Ressourcenbelastungen und Personen- und Materialbedarfe berechnet werden.
A simplification of complex production problems can be achieved by a hierarchical structuring. Methods such as abstraction, reduction or grouping of planning objects (resources or operations) allow a faster and more accurate calculation of delivery dates. At the same time they enable to forecast long term resource and personal loads and material requirements. Applying these methods we get an abstraction of a production problem using the same model description, that allows to apply known scheduling algorithms and simple and user friendly manipulation.
Soluble Interleukin‐1 Receptor Type II Levels in Gingival Crevicular Fluid in Aggressive and Chronic Periodontitis
Authors: Suzuki M. , Ishihara Y. , Kamiya Y. , Koide M. , Fuma D. , Fujita S. , Matsumura Y. , Suga T. , Kamei H. , Noguchi T. 
Published: March 2008

Background: Interleukin (IL)‐1 is closely related to the initiation and progression of periodontal disease. IL‐1 levels in the gingival crevicular fluid (GCF) of subjects with periodontitis are higher than those in periodontally healthy controls, and the levels of IL‐1 correlate with disease severity. However, soluble IL‐1 receptor type II (sIL‐1RII), which acts as a decoy receptor for IL‐1s, has not been investigated in detail in periodontal disease. The purpose of this study was to measure sIL‐1RII levels in the GCF of subjects with chronic or aggressive periodontitis; the correlation between the sIL‐1RII levels in GCF and clinical parameters also was examined.Methods: IL‐1β and sIL‐1RII were measured in 64 GCF samples collected from 47 subjects with chronic periodontitis (CP) and 17 subjects with aggressive periodontitis (AgP). The clinical characteristics of each site were recorded at the time of GCF sampling. IL‐1β and sIL‐1RII were measured by specific non–cross‐reactive enzyme‐linked immunosorbent assay.Results: The disease severity was comparable in CP and AgP. IL‐1β was detected in 98% of CP GCF samples and 88% of AgP GCF samples. sIL‐1RII was detected in 55% of CP GCF samples and 35% of AgP GCF samples. However, the concentrations of IL‐β and sIL‐1RII detected in GCF from subjects with CP or AgP were similar.Conclusion: sIL‐1RII was detected more often in CP GCF than in AgP GCF, and there was no correlation between GCF sIL‐1RII concentration and clinical parameters.
Sarcoidosis Presenting as Gingival Erosion in a Patient Under Long‐Term Clinical Control
Authors: Antunes Karinne B. , Miranda Águida M.M.A. , Carvalho Sônia R. da S. , Azevedo André L. da R. , Tatakis Dimitris N. , Pires Fábio R. 
Published: March 2008

Background: Sarcoidosis is an inflammatory granulomatous systemic disease that rarely affects the oral cavity. Gingival involvement has been reported in only a very limited number of cases, occasionally as the first manifestation of the disease. This article reports a case of sarcoidosis affecting the gingiva and alveolar mucosa in a patient previously treated for the systemic disease and considered under long‐term clinical control.Methods: A 57‐year‐old white female presented with a chief complaint of gingival pain in the maxillary right area lasting 3 years. Clinical examination revealed an erythematous, ill‐defined erosive macule on the buccal aspect of the maxillary right gingiva extending from the canine to the third molar. The medical history included a diagnosis of sarcoidosis 16 years prior to presentation, which was considered to be under clinical control for the last 11 years. An incisional biopsy was obtained.Results: Histopathology indicated the presence of an intense chronic inflammatory infiltrate and focal areas with non‐caseating granulomas. Periodic acid‐Schiff and Grocott's stains were negative for microorganisms, and the diagnosis was compatible with sarcoidosis. Systemic evaluation showed no involvement of other areas and organs, and the patient was managed with topical steroid therapy using silicone trays in conjunction with conventional periodontal therapy and oral hygiene instructions. Complete response was achieved after 6 months, and the patient remains in clinical follow‐up.Conclusion: Although sarcoidosis is a systemic disease that rarely affects the gingiva, the possibility of gingival involvement as the sole manifestation of the disease should be considered in the differential diagnosis of gingival lesions.
The Effect of Adjunctive Subantimicrobial Dose Doxycycline Therapy on GCF EMMPRIN Levels in Chronic Periodontitis
Authors: Emingil Gülnur , Atilla Gül , Sorsa Timo , Tervahartiala Taina 
Published: March 2008

Background: The aim of the present randomized, double‐masked, placebo‐controlled, parallel‐arm study was to examine the effectiveness of a 3‐month regimen of subantimicrobial dose doxycycline (SDD) in combination with scaling and root planing compared to scaling and root planing alone on levels of gingival crevicular fluid (GCF) extracellular matrix metalloproteinase inducer (EMMPRIN) in patients with chronic periodontitis.Methods: GCF samples were collected, and clinical parameters, including probing depth (PD), clinical attachment level, gingival index (GI), and plaque index, were recorded. Thirty chronic periodontitis subjects were randomized to receive SDD or placebo. The SDD group received SDD (20 mg, twice a day) for 3 months plus scaling and root planing, whereas the placebo group took placebo capsules twice a day for 3 months and received scaling and root planing. The subjects were reevaluated at 3 and 6 months. At each visit, all clinical parameters were measured and GCF was sampled. GCF EMMPRIN levels were determined by Western immunoblotting assay. Intragroup comparisons were tested by the Friedman test followed by the Wilcoxon signed‐rank test to analyze the significance of changes over time. The Mann‐Whitney test was used to determine differences between the SDD and placebo groups.Results: Significant improvements were observed in all clinical parameters in the SDD group over the 6‐month study period (P <0.025). The SDD group showed a significantly greater reduction in mean PD scores at 6 months and in mean GI scores at 3 and 6 months than the placebo group (P <0.05). From baseline to 6 months, the GCF EMMPRIN levels were reduced significantly in the SDD group (P <0.025). The GCF EMMPRIN level in the SDD group was significantly lower than that of the placebo group at 3 and 6 months (P <0.05).Conclusions: SDD therapy in combination with scaling and root planing reduced GCF EMMPRIN levels and improved clinical periodontal parameters in subjects with chronic periodontitis. The ability of SDD to downregulate, in vivo, the GCF levels of EMMPRIN, a unique upregulator of matrix metalloproteinase expression, is one of its beneficial host‐modulatory properties. These results expand the usefulness of SDD therapy as an adjunct to scaling and root planing in the long‐term management of periodontal disease.
Interleukin‐1 Gene Polymorphism, Diabetes, and Periodontitis: Results From the Study of Health in Pomerania (SHIP)
Authors: Struch Franziska , Dau Michael , Schwahn Christian , Biffar Reiner , Kocher Thomas , Meisel Peter 
Published: March 2008

Background: Periodontitis is a bacterial inflammatory disease leading to attachment loss with the consequence of tooth loss. There exists a multifactorial risk pattern including bacterial challenge, age, smoking, diabetes mellitus, as well as socioeconomic and genetic factors. An interleukin (IL)‐1 haplotype is associated with periodontitis. We report the relationship between type 2 diabetes, the IL‐1A/1B haplotype, and periodontitis in a population‐based study.Methods: In a cross‐sectional health survey in northeast Germany, we genotyped 1,515 subjects aged 40 to 60 years for the IL‐1 genotype, examined their periodontal status, and assessed diabetes, including the history of diagnosed diabetes, the use of antidiabetic medications, and hemoglobin A1c (HbA1c) measures.Results: Subjects with increased levels of HbA1c had more widespread and severe periodontal disease than normoglycemic subjects. There is a gene–environmental interaction because diabetic subjects bearing a variant IL‐1 genotype C/T or T/T had an enhanced risk for periodontal disease in comparison with their IL‐1 wild‐type counterparts. Bleeding on probing (P = 0.007), attachment loss (P = 0.009), and number of teeth (P <0.001) were associated significantly with diabetes and the IL‐1 genotype. Logistic regression and a matched‐pair analysis confirmed these results.Conclusion: Subjects with type 2 diabetes have an increased risk for periodontitis, which is aggravated further if combined with the variant IL‐1A/1B genotype.
Modified‐Release Subantimicrobial Dose Doxycycline Enhances Scaling and Root Planing in Subjects With Periodontal Disease
Authors: Preshaw Philip M. , Novak M. John , Mellonig James , Magnusson Ingvar , Polson Alan , Giannobile William V. , Rowland Randal W. , Thomas John , Walker Clay , Dawson Dolphus R. , Sharkey Dennis , Bradshaw Mark H. 
Published: March 2008

Background: Previous studies showed that adjunctive subantimicrobial dose doxycycline (SDD; 20 mg, twice daily) provides significant clinical benefits to scaling and root planing (SRP). A modified‐release SDD formulation containing 40 mg doxycycline (SDD‐40) to be taken once daily has been developed. The aim of this study was to investigate the efficacy of SDD‐40 when used as an adjunct to SRP for the treatment of periodontitis.Methods: A 9‐month, double‐masked, randomized, placebo‐controlled, multicenter study was conducted to test the efficacy of adjunctive SDD‐40 in 266 subjects with periodontitis. Subjects were treated by SRP and randomized to receive SDD‐40 or placebo for 9 months with evaluations at 3, 6, and 9 months.Results: Adjunctive SDD‐40 provided significantly greater clinical benefits than placebo at all time points. At month 9, at sites with baseline probing depths (PD) ≥6 mm, 72% to 76% of sites in the SDD‐40 group demonstrated clinically significant PD reductions and clinical attachment level (CAL) gains ≥2 mm compared to 56% to 58% of sites in the placebo group (P <0.0001); 48% to 52% of sites in the SDD‐40 group demonstrated PD reductions and CAL gains ≥3 mm compared to 32% of sites in the placebo group (P <0.0001). In moderate sites (baseline PD 4 to 6 mm), adjunctive SDD‐40 provided significant clinical benefits compared to placebo for mean CAL (all time points: P <0.05), PD (3 months: P = 0.002; 6 and 9 months: P = 0.001), and bleeding on probing (BOP) (3 months: P <0.01; 6 months: P <0.02; 9 months: P <0.05). In deep sites (baseline PD ≥7 mm), SDD‐40 provided significant benefits over control for mean CAL (3 months: P <0.05; 6 and 9 months: P <0.01), PD (all time points: P <0.001), and BOP (3 months: P <0.05; 6 months: not statistically significant; 9 months: P <0.05). Compliance with study medication was high (>92%) with no significant differences in adverse events between groups and no evidence of microbiologically significant changes or development of antibiotic resistance in the subgingival flora in either group.Conclusion: SDD‐40 used as an adjunct to SRP resulted in significantly greater clinical benefits than SRP alone in the treatment of periodontitis.
Photoionization of 3d electrons of Xe, Cs and Ba endohedral atoms: comparative analyses
Authors: Amusia Miron , Baltenkov Arkadiy , Chernysheva Larissa 
Published: March 2008

Abstract
We demonstrate rather interesting manifestations of co-existence of resonance features in characteristics of the photoionization of 3d-electrons in Xe, Cs and Ba endohedral atoms. It is shown that for all of the considered atoms the reflection by the fullerene shell of photoelectrons produced by the 3d subshell photoionization affects greatly partial photoionization cross-sections of 3d
5/2 and 3d
3/2 levels and respective angular anisotropy parameters, both dipole and non-dipole adding to all of them additional maximums and minimums. The results obtained demonstrate distinctive differences between the three atoms. The calculations are performed treating the 3/2 and 5/2 electrons as electrons of different kinds with their spins “up” and “down”. The effect of the C60 shell is accounted for in the frame of the “orange” skin potential model. It is essential that in the considered photon frequency region the presented resonance features are not affected by the C60polarization.
Electro-optical properties of all-oxide p-CuAlO2/n-ZnO: Al transparent heterojunction thin film diode fabricated on glass substrate
Authors: Banerjee Arghya , Chattopadhyay Kalyan 
Published: March 2008

Abstract
We report on the fabrication of all transparent heterojunction thin film diodes of the form glass/n-ZnO: Al/p-CuAlO2 produced by a combinatorial chemical and physical technique and on a study of their electro-optical properties. The n-ZnO: Al layer was deposited by a sol-gel-dip-coating process whereas the p-CuAlO2 layer was deposited by direct current sputtering techniques. The diode structure, with a total thickness of 1100 nm showed around 60% transmittance in the visible region. The current-voltage characteristics of the device showed a rectifying nature, with a low turn-on voltage around 0.8 V, having a rectification ratio > 50 at ± 2 V. The low turn-on voltage and moderate visible transmittance of the transparent diode indicate its potential application in the field of “Transparent” or “Invisible Electronics”.
Boundary sources in the Doran-Lobo-Crawford spacetime
Authors: Culetu Hristu 
Published: March 2008

Abstract
We take a null hypersurface (causal horizon) generated by a congruence of null geodesics as the boundary of the Doran-Lobo-Crawford spacetime to be the place where the Brown-York quasilocal energy is located. The components of the outer and inner stress tensors are computed and shown to depend on time and on the impact parameter b of the test-particle trajectory. The spacetime is a solution of Einstein’s equations with an anisotropic fluid as source. The surface energy density σ on the boundary is given by the same expression as that obtained previously for the energy stored on a Rindler horizon. For time intervals long compared to b (when the stretched horizon tends to the causal one), the components of the stress tensors become constant.
Effects of ion implantation on yellow luminescence in unintentional doped n-type GaN
Authors: Zhang Limin , Zhang Xiaodong , You Wei , Yang Zhen , Wang WenXiu , Ge Qing , Liu Zhengmin 
Published: March 2008

Abstract
The effects of Si, O, C and N ion implantation with different implantation doses on yellow luminescence (YL) of GaN have been investigated. The as-grown GaN samples used in the work were of unintentional doped n-type, and the photoluminescence (PL) spectra of samples had strong YL. The experimental results showed that YL of ion implanted samples exhibited marked reductions compared to samples with no implantation, while the near band edge (NBE) emissions were reduced to a lesser extent. The deep-level centers associated with YL may be produced in GaN films by O and C ion implantation, and identities of these deep-level centers were analyzed. It was also found that the dose dependence of YL was analogous with the one of the intensity ratios of YL to the near band edge (NBE) emission (I
YL/I
NBE) for ion implanted samples. The possible reason for this comparability has been proposed.
Monte Carlo study on bilayer thin films magnetic properties dependence with discontinouos anisotropy parameters
Authors: Bîrsan Eugen 
Published: March 2008

Abstract
In the last few years there has been significant interest in the field of thin films, due to numerous specific phenomena related to the low dimension of these systems, and to the large opportunities in development of high technologies based on their specific magnetic and electronic properties. When dealing with systems of reduced dimensionality it is important to take into account the influence of magnetic anisotropies. In this paper we investigate the magnetic properties of bilayer thin film. This behavior is modeled using Monte Carlo simulations, in the Extended Anisotropic Heisenberg Model. The magnetization, out-of-plane and in-plane magnetic susceptibilities, and also the specific heat bearings according to temperature are investigated in order to find the potential magnetic ordering phases and the critical temperatures, for two sets parameter assignments. For quasi-uniform anisotropy parameters of the film we detect the ferromagnetism-paramagnetism transition and then, by changing the model parameters values, we relieve a short range ferromagnetic ordering phase arising from the antiferromagnetic base layer coupling influence and from easy-plane anisotropy discontinuity on the layers interface.
Relativistic solution in D-dimensions to a spin-zero particle for equal scalar and vector ring-shaped Kratzer potential
Authors: Ikhdair Sameer , Sever Ramazan 
Published: March 2008

Abstract
The Klein-Gordon equation in D-dimensions for a recently proposed ring-shaped Kratzer potential is solved analytically by means of the conventional Nikiforov-Uvarov method. The exact energy bound states and the corresponding wave functions of the Klein-Gordon are obtained in the presence of the non-central equal scalar and vector potentials. The results obtained in this work are more general and can be reduced to the standard forms in three dimensions given by other works.
Cell separation with horizontal cell electrophoresis under near-isopycnic conditions on a “density cushion”
Authors: Wilk Anna , Urbańska Katarzyna , Woolley David , Korohoda Włodzimierz 
Published: March 2008

AbstractThis report describes an improvement made to the horizontal cell electrophoresis methodology. It involves using two liquid layers differing in density to produce an interface described as a “density cushion”. The electrophoretic system that employed an anti-convective porous matrix to separate red blood cells (RBC) and charged dyes effectively was found to be unsuitable for some other mammalian cells. The “density cushion” method was found to be more versatile and applicable to studies on the separation of a variety of cell types. The experiments described show the differences between the electrophoretic mobilities of a human eosinophilic leukaemia cell line (Eol-1) and RBC, both with and without the modification of the cell surface properties.
Abbreviated dose rituximab for immune‐mediated hematological disorders
Authors: Fairweather Helen , Tuckfield Annabel , Grigg Andrew 
Published: March 2008

AbstractAs rituximab, a monoclonal antibody targeting CD20, depletes B cells, there is considerable interest in its use in immune‐mediated disorders. The majority of studies employ a four‐dose regimen based on practice in lymphoma therapy. We describe our experience with one or two doses of 375 mg/m2 of rituximab in 12 patients with relapsed and refractory immune‐mediated hematological disorders. Eleven patients (92%) achieved a complete remission that has been sustained in 7 for a median of 14.5 (10.5–22) months. Four patients (36%) relapsed after responses of 1–18.5 months. This preliminary experience suggests that one or two doses of rituximab may have response and relapse rates comparable to multidose regimens while potentially providing considerable cost savings. Further prospective studies are planned. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.