bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile and cost-effective fabrication of wearable alpha-naphtholphthalein-based halochromic sensor for wound pH monitoring
Authors: Seo Hee Sung , Lim Hyejin , Lim Taekyung , Seo Keumyoung , Yang Jonguk , Kang Youngsoo , Han Shin Ji , Ju Sanghyun , Jeong Sang-Mi 
Published: March 2024

Abstract
The sensor, designed to be worn directly on the skin, is suitable for real-time monitoring of the recovery level of not only general wounds, but also difficult-to-heal wounds, such as those with chronic inflammation. Notably, healthy skin has a pH range of 4–6. When a wound occurs, the pH is known to be approximately 7.4. In this study, alpha-naphtholphthalein (Naph) was immersed in a cotton-blended textile to produce a wearable halochromic sensor that clearly changed color depending on the pH of the skin in the range 6–9, including pH 7.4, which is the skin infection state. The coating was performed without using an organic solvent by dissolving it in micelle form using cetyltrimethylammonium bromide, a surfactant, in water. Naph-based halochromic sensor shows light yellow, which is the dye’s own color, at pH 6, which is a healthy skin condition, and gradually showed a clear color change to light green-green-blue as pH increased. Even after washing and drying by rubbing with regular tap water, the color change due to pH was maintained more than 10 times. Naph-based halochromic sensors use a simple solution production and coating method and are not only reusable sensors that can be washed with water but also use environmentally friendly water, making them very suitable for developing commercial products for wound pH monitoring. In addition, it can be easily applied to medical supplies, such as medical gauze, patient clothes, and compression bandages, as well as everyday wear, such as clothing, gloves, and socks. Therefore, it is expected to be widely used as a wound pH sensor, allowing real-time monitoring of the skin condition of individuals with chronic skin inflammation, including patients requiring wound recovery.
Circular polarization sensitive opto-neuromorphic operation at plasmonic hot electron transistor using chiral gold nanoparticles
Authors: Namgung Seok Daniel , Kim Ryeong Myeong , Han Jeong Hyun , Nam Ki Tae 
Published: March 2024

Abstract
Opto-neuromorphic operation is critical for biological system to recognize the visual objects and mimicking such operation is important for artificial prosthesis as well as machine vision system for industrial applications. To sophisticatedly mimic biological system, regulation of learning and memorizing efficiency is needed, however engineered synthetic platform has been lack of controllability, which makes huge gap between biological system and synthetic platform. Here we demonstrated controllable learning and memorizing opto-neuromorphic operation at plasmonic hot electron transistor. Especially, circularly polarized light (CPL) sensitive synaptic characteristics and learning experience capability are enabled by incorporating chiral plasmonic nanoparticle. Furthermore, gate voltage gives rise to controllable neuromorphic operation due to hot electron injection and trapping effect, resulting in high remaining synaptic weight of ∼70% at negative gate voltage under CPL excitation. We believe that this discovery makes significant leap toward on-demand in-sensor computing as well as toward bio-realistic device.
Through the ages: a commentary on ‘Diversification of quantitative morphological traits in wheat’
Authors: Burgess Alexandra J 
Published: March 2024

This article comments on:
Yixiang Shan and Colin P. Osborne, Diversification of quantitative morphological traits in wheat, Annals of Botany, Volume 133, Issue 3, 1 March 2024, Pages 413–426 https://doi.org/10.1093/aob/mcad202
High yield clinical applications for photon counting CT in neurovascular imaging
Authors: Madhavan Ajay A , Bathla Girish , Benson John C , Diehn Felix E , Nagelschneider Alex A , Lehman Vance T 
Published: March 2024

Abstract
Photon-counting CT (PCCT) uses a novel X-ray detection mechanism that confers many advantages over that used in traditional energy integrating CT. As PCCT becomes more available, it is important to thoroughly understand its benefits and highest yield areas for improvements in diagnosis of various diseases. Based on our early experience, we have identified several areas of neurovascular imaging in which PCCT shows promise. Here, we describe the benefits in diagnosing arterial and venous diseases in the head, neck, and spine. Specifically, we focus on applications in head and neck CT angiography (CTA), spinal CT angiography, and CT myelography for detection of CSF-venous fistulas. Each of these applications highlights the technological advantages of PCCT in neurovascular imaging. Further understanding of these applications will not only benefit institutions incorporating PCCT into their practices but will also help guide future directions for implementation of PCCT for diagnosing other pathologies in neuroimaging.
Kidney involvement in Wilson's disease: a review of the literature
Authors: Dang Julien , Chevalier Kevin , Letavernier Emmanuel , Tissandier Come , Mouawad Sarah , Debray Dominique , Obadia Mickaël , Poujois Aurélia 
Published: March 2024

ABSTRACTWilson's disease (WD) is a rare inherited disease due to the mutation of the ATP7B gene, resulting in impaired hepatic copper excretion and its pathological accumulation in various organs such as the liver, the nervous system, or the kidneys. Whereas liver failure and neuropsychiatric disorders are the most common features, less is known about the renal complications. We conducted a review of the literature to define the characteristics and pathophysiology of kidney involvement during WD. This review shed light on strong evidence for direct copper toxicity to renal tubular cells. Excessive tubular copper accumulation might present with various degrees of tubular dysfunction, ranging from mild hydroelectrolytic and acid–base disorders to complete Fanconi syndrome. Proximal and distal renal tubular acidosis also favors development of nephrolithiasis, nephrocalcinosis, and bone metabolism abnormalities. Indirect complications might involve renal hypoperfusion as occurs in hepatorenal or cardiorenal syndrome, but also tubular casts’ formation during acute hemolysis, rhabdomyolysis, or bile cast nephropathy. Acute kidney failure is not uncommon in severe WD patients, and independently increases mortality. Finally, specific and long-term therapy by D-penicillamin, one of the most efficient drugs in WD, can cause glomerular injuries, such as membranous nephropathy, minimal-change disease, and, rarely, severe glomerulonephritis. Altogether, our study supports the need for interdisciplinary evaluation of WD patients involving nephrologists, with regular monitoring of tubular and glomerular functions, to provide adequate prevention of renal and bone involvement.
Seismic scattering regimes from multiscale entropy and frequency correlations
Authors: Eaton Will , Haindl Claudia , Nissen-Meyer Tarje 
Published: March 2024

SUMMARY
Seismic-wave scattering is observed, to variable degrees, on Earth, its moon and Mars. Current scattering models and data processing typically rely on two end-member phenomena: weak, single- or multiple-scattering events (ballistic) on the one hand, or intense scattering such that the wavefield retains no path information or bearing on its origin (diffuse).This study explores the existence of scattering behaviour intermediate between these end-members, as well as the properties of heterogeneous media that facilitate a transition between them. We apply multiscale entropy and frequency-correlation analysis to seismic coda, and observe a distinct transitional behaviour is present within a part of the investigated parameter space. Analysis of terrestrial, lunar and Martian seismograms further demonstrate the applicability of these new methods across a wide range of scattering behaviours, while also highlighting their shortcomings. Results from the planetary data indicate partially non-diffuse behaviour and low complexity within specific bandwidths of lunar wavefields, potentially contradicting the current paradigm that lunar wavefields are diffuse, and require continued study. Furthermore, Martian seismograms are shown to possess greater statistical entropy than lunar seismograms and diffuse energy properties, yet still display distinct phase arrivals, suggesting substantial scattering and transitional scattering behaviour on Mars. The robust, comparative nature of multiscale entropy and frequency-correlation analysis, applied to idealised simulation as well as three separate planetary bodies, provides a promising framework for future exploration of scattered wavefields across ballistic, transitional and diffuse regimes, that complements existing methods.
A Novel Approach for Single-Step Analyte Fractionation of Raw Milk Prior to Antibiotic Residue Trace Analysis as an Alternative to QuEchERS-Based Extraction
Authors: Steils Jan-Michael , Lang Maren , Kraus Melina , Schöne Klaus , Cashman John , Baumgartner Christian 
Published: March 2024

Abstract

Background
Antibiotic residues in milk are a well-known hazard in the dairy food chain. Detection methods for these residues, such as nonspecific microbiological inhibitor tests or group-specific receptor tests, are relatively inexpensive, easy to use, and widely applied to ensure food safety. In contrast, specific detection by liquid chromatography–tandem mass spectrometry (LC–MS/MS)—although a critical, complimentary method to confirm the results of nonspecific testing—is relatively costly, time-consuming, and laborious. Furthermore, sample processing before LC–MS/MS analysis requires unique preparation procedures for different groups of antibiotic compounds.

Objective
To simplify and speed up specific antibiotic residue detection, a low-cost, passive, and single-step method to fractionate analytes in raw milk was developed.

Methods
Untreated raw milk was fractionated into its water and fat/protein phases using a Fractionation of Milk for Trace Analysis of Contaminants and Residues for Antibiotics (FraMiTrACR® AB) fractionation unit. The water fraction was then analyzed by LC–MS/MS. The analyte fractionation method was evaluated against a Quick Easy Cheap Effective Rugged and Safe (QuEChERS)-based method for sample preparation.

Results
Our method allows qualitative and quantitative detection of substances from the penicillin, cephalosporin, macrolide, lincosamide, sulfonamide, tetracycline, and fluoroquinolone groups of antibiotics. Detection limits are below the legally prescribed maximum residue levels, allowing reliable, specific, and rapid validation of a positive result in nonspecific microbiological inhibitor tests.

Conclusion
Analyte fractionation by FraMiTrACR AB is a faster alternative to QuEChERS-based sample preparation for the detection of antibiotic substances in milk.

Highlight
This method describes a low-cost, environmentally friendly, passive, and single-step milk analyte fractionation. As an alternative to QuEChERS-based preparation, this fractionation method simplifies and speeds up the process for specific antibiotic residue detection.
Influence of temperature variability on the feeding behavior and blood consumption of Triatoma infestans (Hemiptera: Reduviidae)
Authors: Álvarez-Duhart Bárbara , Cavieres Grisel , González Avia , Cattan Pedro E , Bozinovic Francisco , Clavijo-Baquet Sabrina 
Published: March 2024

Abstract
The transmission and incidence of vector-borne diseases rely on vector distribution and life history traits such as survival, fecundity, and feeding. Since arthropod disease vectors are ectotherms, these vital rates are strongly influenced by temperature. Chagas disease is a neglected tropical disease caused by the protozoan parasite, Trypanosoma cruzi. This parasite is transmitted when the feces of the infected triatomine enter the bloodstream of the host. One of the most important vector-species of this disease in the Southern Cone region of South America is Triatoma infestans. In this study, we evaluated the role of constant and variable environmental temperature on the feeding behavior of T. infestans. Fifth-instar nymphs were acclimatized to 4 thermal treatments comprising 2 temperatures (27 °C and 18 °C) with and without diurnal thermal variability (27 ± 5 °C and 18 ± 5 °C). Individuals were fed weekly for 7 wk to quantify their feeding. Our results showed lower feeding frequency in nymphs acclimatized to cold temperature compared to those from warmer temperature treatments. However, treatments with thermal variability presented a nonlinear effect on feeding, with an increased feeding rate in the cold, variable treatment and a decreased feeding rate in the warm, variable treatment. Individuals maintained under cold treatments, the variable temperature exhibited a higher feeding rate and the lowest amount of ingested blood among all treatments. Thus, natural diurnal temperature variation cannot be ignored if we are to make more accurate T. cruzi transmission risk predictions now and in the future.
Empowering social media users: nudge toward self-engaged verification for improved truth and sharing discernment
Authors: Tu Fangjing 
Published: March 2024

Abstract
How can we empower social media users to better discern the veracity of news and share less false news? This survey experiment (N = 636) assessed the effectiveness of two interventions—signing a Pro-Truth Pledge and utilizing a Fact-Checking Guide. Results showed that utilizing the Fact-Checking Guide increased skepticism of news posts, likelihood to verify news posts, verification engagement, and reduced intention to share news without regard to news veracity. Before and after comparisons indicated that after verification engagement activities, truth and sharing discernment improved with higher factual accuracy ratings for true news, lower accuracy ratings for false news, and a greater likelihood to share true news compared to false news. Individual’s engagement in verification was identified as a crucial mechanism through which the Fact-Checking Guide intervention led to better truth and sharing discernment. The study could inform social media designs that promote a truthful news environment.
Modeling of a tissue expander with a radiofrequency identification port in postmastectomy radiation therapy planning
Authors: Matsubayashi Fumiyasu , Takahashi Taro , Miyauchi Hikaru , Ito Yasushi , Harada Arisa , Yoshioka Yasuo 
Published: March 2024

Abstract
The purpose of this study was to evaluate the dose attenuation of Motiva Flora® (Flora, Establishment Labs, Alajuela, Costa Rica) tissue expander with a radiofrequency identification port locator and to develop a model for accurate postmastectomy radiation therapy planning. Dose attenuation was measured using an EBT3 film (Ashland, Bridgewater, NJ), and the optimal material and density assignment for the radiofrequency identification coil for dose calculation were investigated using the AcurosXB algorithm on the Eclipse (Varian Medical Systems, Palo Alto, CA) treatment planning system. Additionally, we performed in vivo dosimetry analysis using irradiation tangential to the Flora tissue expander to validate the modeling accuracy. Dose attenuations downstream of the Flora radiofrequency identification coil was 1.29% for a 6 MV X-ray and 0.99% for a 10 MV X-ray when the coil was placed perpendicular to the beam. The most suitable assignments for the material and density of the radiofrequency identification coil were aluminum and 2.27 g/cm3, respectively, even though the coil was actually made of copper. Gamma analysis of in vivo dosimetry with criteria of 3% and 2 mm did not fail in the coil region. Therefore, we conclude that the model is reasonable for clinical use.
Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation
Authors: Hayashi Ryota , Okumura Hikaru , Isono Mayu , Yamauchi Motohiro , Unami Daiki , Lusi Rahmartani Tania , Yamamoto Masamichi , Kato Yu , Uchihara Yuki , Shibata Atsushi 
Published: March 2024

Abstract
Ionizing radiation (IR)-induced double-strand breaks (DSBs) are primarily repaired by non-homologous end joining or homologous recombination (HR) in human cells. DSB repair requires adenosine-5′-triphosphate (ATP) for protein kinase activities in the multiple steps of DSB repair, such as DNA ligation, chromatin remodeling, and DNA damage signaling via protein kinase and ATPase activities. To investigate whether low ATP culture conditions affect the recruitment of repair proteins at DSB sites, IR-induced foci were examined in the presence of ATP synthesis inhibitors. We found that p53 binding protein 1 foci formation was modestly reduced under low ATP conditions after IR, although phosphorylated histone H2AX and mediator of DNA damage checkpoint 1 foci formation were not impaired. Next, we examined the foci formation of breast cancer susceptibility gene I (BRCA1), replication protein A (RPA) and radiation 51 (RAD51), which are HR factors, in G2 phase cells following IR. Interestingly, BRCA1 and RPA foci in the G2 phase were significantly reduced under low ATP conditions compared to that under normal culture conditions. Notably, RAD51 foci were drastically impaired under low ATP conditions. These results suggest that HR does not effectively progress under low ATP conditions; in particular, ATP shortages impair downstream steps in HR, such as RAD51 loading. Taken together, these results suggest that the maintenance of cellular ATP levels is critical for DNA damage response and HR progression after IR.
Microcystic serous cystadenoma of the pancreas causing biliary obstruction: a case report and review of the literature
Authors: Bland Sydney , Thompson III William 
Published: March 2024

Abstract
Cystic tumors account for 15% of pancreatic tumors. Of these, serous microcystic adenomas represent 1–2% of pancreatic exocrine neoplasms. While typically benign, a small percentage possess malignant potential. Given imaging improvements, serous cystadenomas are being identified more frequently. A 63-year-old female was admitted with complaints of jaundice and unintentional weight loss. Abdominal computed tomography scan showed a 16 cm obstructive pancreatic mass near the porta hepatis region. Endoscopic ultrasonography and fine needle aspiration biopsy indicated a large pancreatic head cystic mass favoring serous microcystadenoma causing biliary and some pyloric obstruction. Malignant potential could not be ruled out because of size and symptoms. A pylorus-preserving pancreaticoduodenectomy revealed a cystic tumor invading the pancreatic duct and adhering to the duodenum of the pancreatic head. Pathology confirmed a 15 cm benign pancreatic serous cystadenoma. Although most serous cystadenomas are benign, surgical resection was prudent given the size, symptoms, and adjacent organ involvement.
Stop exsanguination by inflation: management of aorta-esophageal fistula bleeding
Authors: Pagano Kristina M , Fokin Alexander A , Parra Michael , Puente Ivan 
Published: March 2024

Abstract
Aortoesophageal fistula is rare and typically presents itself to the emergency department as Chiari’s Triad of mid-thoracic pain, sentinel arterial hemorrhage, and exsanguination after a symptom-free interval. However, fatal bleeding may be the first and last presentation of an aortoesophageal fistula. When a patient experiences massive hematemesis without witnesses, EMS may assume that bleed is of a traumatic mechanism. We present a case of a 59-year-old male with no previous medical history who was transported to a trauma center unconscious and with massive bleeding of unknown origin. Computed tomography revealed a thoracic aortic aneurysm and an aortoesophageal fistula. Bleeding was not controlled and the patient expired. Trauma bay personnel should follow an algorithm which includes a prompt tamponade of the bleed using a Sengstaken–Blakemore tube or esophageal balloon paralleled by massive transfusion and obtaining an early computed tomography scan to manage patients with massive gastroesophageal bleeding until appropriate surgical interventions can be initiated.
Anterior segment migration of intravitreal dexamethasone implant in a patient with scleral fixation intraocular lens implant: a case report
Authors: ALBalawi Hani B , Alali Naif M , Altemani Abdullah H , Magliyah Moustafa S , ASharari Khaled S , ALRubayyi Maram S , Hashem Faris , Alenezi Saad H 
Published: March 2024

Abstract
Corticosteroids are crucial for treating inflammatory ocular conditions. The development of dexamethasone revolutionized targeted ocular therapy. Ozurdex, a dexamethasone implant, effectively treats various eye conditions but carries risks such as implant migration. This is a case of anterior segment migration of intravitreal dexamethasone implant, Ozurdex, in a patient with scleral fixation intraocular lens implant in whom conservative management with supine positioning and pharmacologic pupil dilation can help retain the implant back in the vitreous. Patients at high risk of Ozurdex migration should avoid its use. Educate patients on the risk of implant migration and signs of migration to present immediately to an ophthalmology emergency department to avoid corneal damage. It is essential to identify high-risk patients before considering Ozurdex migration. In some cases, conservative management can be initiated while preparing for surgical removal.
A diagnostic dilemma: a case report of concomitant duodenal Dieulafoy lesion and gastric ulcer
Authors: Wallace Lauren , Gallagher Peter J 
Published: March 2024

Abstract
Dieulafoy lesions (DL) are an uncommon cause of gastrointestinal bleeding which is often difficult to diagnose due to the rarity of the condition and varying clinical presentations. This case describes an unusual presentation of upper gastrointestinal bleeding in an 85-year-old female with findings on two separate gastroscopies of both a gastric ulcer and duodenal DL. The pathophysiology of DL remains poorly understood and despite shared risk factors, these two pathologies are rarely reported concurrently. The presence of a concomitant gastric ulcer further complicated the diagnosis and treatment of the duodenal DL in this case. This highlights the importance of clinician awareness of this pathology and its presentation and the need for early repeat endoscopy.
Understanding diabetic cheiroarthropathy: a focus on clinical presentation
Authors: Persad-Paisley Elijah M , Lee Chanbin , Bhatt Reena A 
Published: March 2024

Abstract
Diabetic cheiroarthropathy (DCA) is a relatively uncommon and underdiagnosed complication of poorly controlled diabetes. It is caused by non-enzymatic glycation of collagen that ultimately leads to microvascular damage and polyarticular stiffness. If diagnosed early, optimal management of serum glucose levels may lessen joint stiffness and prevent microvascular and macrovascular complications associated with diabetes mellitus. We review the case of a 55-year-old male with type 2 diabetes mellitus who was diagnosed with DCA after complaints of chronic joint stiffness and immobility.