bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Class of Potent Influenza Virus Inhibitors: Polysubstituted Acylthiourea and Its Fused Heterocycle Derivatives.
Authors: Sun Chuanwen , Huang Hai , Feng Meiqing , Shi Xunlong , Zhang Xiaodong , Zhou Pei 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heterocyclic Compounds from 4H‐3,1‐Benzoxazin‐4‐one Derivatives as Anticancer Agent.
Authors: Abel‐Rahman Taha M. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Single‐Step Syntheses of 2‐Amino‐7‐chlorothiazolo[5,4‐d]pyrimidines: Intermediates for Bivalent Thiazolopyrimidines.
Authors: Liu Jian , Patch Raymond J. , Schubert Carsten , Player Mark R. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
3‐Arylpiperazinylethyl‐1H‐pyrrolo[2,3‐d]pyrimidine‐2,4(3H,7H)‐dione Derivatives as Novel, High‐Affinity and Selective α1‐Adrenoceptor Ligands.
Authors: Pittala Valeria , et al. et al. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Regiocontrolled Synthesis of Trialkyl‐Substituted Pyrazines.
Authors: Elmaaty Tarek Abou , Castle Lyle W. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Heterocyclic Ring Systems via [1,3,5]Triazino[1,2‐a]benzimidazole Derivatives.
Authors: Primofiore Giampaolo , Da Settimo Federico , Pardi Gianluca , Simorini Francesca , La Motta Concettina , Salerno Silvia , Taliani Sabrina , Marini Anna Maria 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of a Novel Series of 6‐Chloro‐1,4,2‐benzodithiazine 1,1‐Dioxide Derivatives with Potential Biological Activity.
Authors: Brzozowski Z. , Saczewski F. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Properties of New Tetrazines Substituted by Heteroatoms: Towards the World′s Smallest Organic Fluorophores.
Authors: Audebert Pierre , Miomandre Fabien , Clavier Gilles , Vernieres Marie‐Claude , Badre Sophie , Meallet‐Renault Rachel 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substituted 4‐Amino‐2‐benzazepin‐3‐ones via N‐Acyliminium Ion Cyclizations.
Authors: Ballet Steven , Urbanczyk‐Lipkowska Zofia , Tourwe Dirk 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation and Reactivity of 5‐Substituted Azepino[3,4‐b]indoles.
Authors: Montagne C. , Laurent N. , Joseph B. , Merour J.‐Y. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Short and Efficient Approach Towards Macrocyclic Lactones Based on a Sonogashira Reaction.
Authors: Krauss Juergen , Unterreitmeier Doris , Neudert Christine , Bracher Franz 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereospecific Addition of H—P Bond to Alkenes: A Simple Method for the Preparation of (Rp)‐Phenylphosphinates.
Authors: Han Li‐Biao , Zhao Chang‐Qiu 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of β‐Hydroxy Selenides Using Benzeneselenol and Oxiranes under Supramolecular Catalysis in the Presence of β‐Cyclodextrin in Water.
Authors: Sridhar R. , Srinivas B. , Surendra K. , Krishnaveni N. Srilakshmi , Rao K. Rama 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery, SAR, and X‐Ray Structure of Novel Biaryl‐Based Dipeptidyl Peptidase IV Inhibitors.
Authors: Moriarty Kevin J. , et al. et al. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Preliminary Biological Evaluation of (2S,1′R,2′S)‐ and (2S,1′S,2′R)‐2‐(2′‐Phosphonocyclopropyl)glycines, Two Novel Conformationally Constrained L‐AP4 Analogues.
Authors: Amori Laura , Serpi Michaela , Marinozzi Maura , Costantino Gabriele , Gavilan Diaz Monica , Hermit Mette Brunsgaard , Thomsen Christian , Pellicciari Roberto 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Multiple Component Approaches to C‐Glycosyl β‐Amino Acids by Complementary One‐Pot Mannich‐Type and Reformatsky‐Type Reactions.
Authors: Dondoni Alessandro , Massi Alessandro , Sabbatini Simona 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Deconjugation of Dehydroamino Acids: Stereoselective Synthesis of Racemic (E)‐Vinylglycines.
Authors: Alexander Paul A. , Marsden Stephen P. , Munoz Subtil Dulce M. , Reader John C. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Concise Enantioselective Synthesis of Furan Lignans (‐)‐Dihydrosesamin and (‐)‐Acuminatin and Furofuran Lignans (‐)‐Sesamin and (‐)‐Methyl Piperitol by Radical Cyclization of Epoxides.
Authors: Banerjee Biplab , Roy Subhas Chandra 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Polyacetylenic Acids (I) Isolated from Nanodea muscosa.
Authors: Alves Diego , Nogueira Cristina W. , Zeni Gilson 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hexylitaconic Acid: A New Inhibitor of p53—HDM2 Interaction Isolated from a Marine‐Derived Fungus, Arthrinium sp.
Authors: Tsukamoto Sachiko , Yoshida Takushi , Hosono Hidetaka , Ohta Tomihisa , Yokosawa Hideyoshi 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A General Method for the Synthesis of Bastaranes and Isobastaranes: First Total Synthesis of Bastadins 5 (I), 10, 12, 16, 20, and 21 (II).
Authors: Couladouros Elias A. , Pitsinos Emmanuel N. , Moutsos Vassilios I. , Sarakinos Georgios 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Desymmetrization and Diastereotopic Group Selection in 1,4‐Cyclohexadienes.
Authors: Studer Armido , Schleth Florian 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oral Cholesteryl Ester Transfer Protein (CETP) Inhibitors: A Potential New Approach for Treating Coronary Artery Disease
Authors: Sikorski James A. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Natural Products to Drugs: Daptomycin and Related Lipopeptide Antibiotics
Authors: Baltz Richard H. , Miao Vivian , Wrigley Stephen K. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Estimation of the Bond Dissociation Energies from the Kinetic Characteristics of Liquid‐Phase Radical Reactions
Authors: Denisov E. T. , Tumanov V. E. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Native State Kinetic Stabilization as a Strategy to Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin Amyloidoses
Authors: Johnson Steven M. , Wiseman R. Luke , Sekijima Yoshiki , Green Nora S. , Adamski‐Werner Sara L. , Kelly Jeffery W. 
Published: March 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry
Authors: Rothaeusler Kristina , Baumgarth Nicole 
Published: March 2006

AbstractBackground:Measurement of cell proliferation via BrdU incorporation in combination with multicolor cell surface staining would facilitate studies on cell subsets that require multiple markers for their identification. However, the extent to which the often harsh cell preparation procedures required affect the staining quality of more recently developed fluorescent dyes has not been assessed.Methods:Three cell preparation protocols for BrdU measurement were compared for their ability to maintain fluorescent surface staining and scatter parameters of in vivo BrdU‐labeled cells by flow cytometry. A 10‐color fluorescent panel was developed to test the quality of surface staining, following cell treatment and the ability to perform BrdU measurements on even small B lymphocyte subsets.Results:All cell preparation procedures affected the quality of fluorescent and/or scatter parameters to varying degrees. Paraformaldehyde/saponin‐based procedures preserved sufficient fluorescent surface staining to determine BrdU incorporation rates among all splenic B cell subsets, including B‐1a cells, which constitute roughly 0.5% of cells. Turnover rates of B‐1a cells were similar to immature B cells and higher than those of the other mature B cell subsets.Conclusion:Paraformaldehyde/saponin‐based cell preparation procedures facilitate detailed cell turnover studies on small cell subsets in vivo, revealing new functional information on rare cell populations. © 2006 International Society for Analytical Cytology
Comparison of three commonly used PCR‐based techniques to analyze MSI status in sporadic colorectal cancer
Authors: Deschoolmeester Vanessa , Baay Marc , Wuyts Wim , Marck Eric Van , Pelckmans Paul , Lardon Filip , Vermorken Jan B. 
Published: March 2006

AbstractSeveral retrospective studies have shown that a high level of microsatellite instability (MSI‐H) is an important prognostic factor of a more favorable outcome in stage II and III colorectal cancer (CRC) patients. In this study, three commonly used polymerase chain reaction (PCR)‐based MSI analysis techniques were compared (polyacrylamide gel electrophoresis followed by silver‐staining [SSPAGE], fluorescence capillary electrophoresis [FCE], and denaturing high‐performance liquid chromatography [DHPLC]) on a limited group of CRC patients, to identify the most optimal detection technique. Pathology blocks of 26 CRC patients were subjected to microdissection and the Bethesda reference panel was used for MSI analysis. Considering the samples analyzed by both SSPAGE and FCE, 8.7% were MSI‐H, 8.7% were MSI‐L, and 82.6% were MSS using SSPAGE. FCE resulted in 16% MSI‐H, 4% MSI‐L, and 80% MSS. Due to difficulties in analyzing the dinucleotide markers on DHPLC, we only analyzed the mononucleotide markers with this technique. The results were 100% concordant to those obtained by FCE. SSPAGE is time consuming, subjective, and less user‐friendly and interpretable. DHPLC was not feasible due to interpretation difficulties for the dinucleotide markers. We recommend the use of FCE to analyze MSI status. This technique is sensitive, reproducible, user‐friendly and leads to easy interpretation and high‐throughput. J. Clin. Lab. Anal. 20:52–61, 2006. © 2006 Wiley‐Liss, Inc.
St. John's wort does not interfere with therapeutic drug monitoring of 12 commonly monitored drugs using immunoassays
Authors: Dasgupta Amitava , Tso Gertie , Szelei‐Stevens Kathy 
Published: March 2006

AbstractSt. John's wort, a popular herbal remedy for depression, is known to interact with many Western drugs because of the ability of its components to induce liver enzymes. Lower concentrations of various drugs due to increased clearance have been reported. Because immunoassays are commonly used in clinical laboratories for therapeutic drug monitoring, we studied the potential interference of St. John's wort with commonly monitored therapeutic drugs. Drug‐free serum pools were supplemented with St. John's wort to achieve in vitro St. John's wort concentrations mimicking in vivo concentrations after both recommended use and overdose. Concentrations of digoxin, tricyclic antidepressants (TCAs), phenytoin, carbamazepine, theophylline, valproic acid, quinidine, phenobarbital, procainamide, and N‐acetyl procainamide were measured in serum. Pooled serum specimens from patients who were taking a particular drug were also supplemented in vitro with concentrations of St. John's wort to investigate whether observed concentrations changed after supplementation with St. John's wort. The effect of St. John's wort on cyclosporine and tacrolimus (FK 506) was studied in whole blood. We found no significant interference from St. John's wort with any assay studied. Moreover, when drug‐free serum was supplemented with very high concentrations of hypericin (2 µg/mL) and hyperforin (2 µg/mL) pure standard, we observed no apparent drug level with any immunoassay. The presence of both hypericin and hyperforin was also confirmed by thin layer chromatography (TLC) in both preparations of St. John's wort. We conclude that immunoassays may be used to measure levels of therapeutic drugs in patients who self‐medicate with St. John's wort. J. Clin. Lab. Anal. 20:62–67, 2006. © 2006 Wiley‐Liss, Inc.
Serum level of sialic acid (SA) and carbohydrate‐deficient transferrin (CDT) in type 2 diabetes mellitus with microvascular complications
Authors: Cylwik Bogdan , Chrostek Lech , Jakimiuk Barbara , Popławska Anna , Szmitkowski Maciej 
Published: March 2006

AbstractSialic acid (SA) is responsible for the composition of different isoforms of transferrin and is reported to be a marker of microvascular complications in type 2 diabetes mellitus. Therefore, we explored the serum concentration of SA, and the less sialylated isoforms of transferrin, termed carbohydrate‐deficient transferrin (CDT), in relation to the presence of microvascular complications in type 2 diabetes mellitus. We studied 21 patients with type 2 diabetes with microangiopathy and 22 patients without complications who were hospitalized at a diabetic clinic. The prevalence of microvascular complications was based on clinical history, fundoscopy, and laboratory tests. Blood samples were taken for measurements of SA, CDT, total transferrin, glucose, HbA1c, fibrinogen, C‐reactive protein (CRP), and indicators of renal dysfunction (i.e., creatinine, urea, albumin excretion rate (AER), and glomerular filtration rate (GFR)). A rise in serum SA and a decrease in CDT concentrations were observed in both diabetic groups with and without complications, and there were no differences between the two groups of patients. There was a statistically significant correlation between serum SA and CDT in diabetic subjects with microvascular complications, but not in patients without such complications. This proves that the serum changes in CDT and SA levels in the course of type 2 diabetes mellitus are associated with each other in the presence of microangiopathy. J. Clin. Lab. Anal. 20:68–73, 2006. © 2006 Wiley‐Liss, Inc.
Principles for psychosocial treatment of personality disorder: Summary of the APA Division 12 Task Force/NASPR review
Authors: Critchfield Kenneth L. , Benjamin Lorna Smith 
Published: March 2006

AbstractA wide variety of clinical problems and relational styles are collected under the diagnostic heading of personality disorder (PD). These disorders involve maladaptive, persistent ways of thinking, feeling, and behaving that are associated with both functional impairment and disturbed interpersonal relationships. Personality disorders are difficult to treat, and challenge a therapist's ability to intervene helpfully, in part because the maladaptive patterns can impact the therapy relationship itself. Therapeutic principles were derived by Task Force review from the small body of research conducted to date with this family of disorders and include characteristics of clients and therapists, their relationship together, and essential elements of technique. The importance of a collaborative relationship as well as a treatment that is comprehensive, empathic, patiently applied, and flexibly tailored to presenting problems are dominant themes across principles. Treatment research with PD is in its early stages and many important areas remain uncharted. The Task Force principles are here summarized in hopes of providing general guidance to clinicians working with PD, as well as to outline research needs for the area. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 661–674, 2006.
Participation in treatment and Alcoholics Anonymous: A 16‐year follow‐up of initially untreated individuals
Authors: Moos Rudolf H. , Moos Bernice S. 
Published: March 2006

AbstractThis study focused on the duration of participation in professional treatment and Alcoholics Anonymous (AA) for previously untreated individuals with alcohol use disorders. These individuals were surveyed at baseline and 1 year, 3 years, 8 years, and 16 years later. Compared with individuals who remained untreated, individuals who obtained 27 weeks or more of treatment in the first year after seeking help had better 16‐year alcohol‐related outcomes. Similarly, individuals who participated in AA for 27 weeks or more had better 16‐year outcomes. Subsequent AA involvement was also associated with better 16‐year outcomes, but this was not true of subsequent treatment. Some of the association between treatment and long‐term alcohol‐related outcomes appears to be due to participation in AA. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 735–750, 2006.
Therapeutic factors in treating anxiety disorders
Authors: Newman Michelle G. , Stiles William B. 
Published: March 2006

AbstractThis article is a condensation of several chapters from Principles of Therapeutic Change That Work edited by L.G. Castonguay and L.E. Beutler. The authors present the work of M.G. Newman, W.B. Stiles, A. Janeck, and S.R. Woody (2006), who outline an integrative model for effective psychotherapy of anxiety disorders. The authors also summarize, review, and extend several chapters on the current knowledge about therapeutic technique factors (S.R. Woody & T.H. Ollendick, 2006), participant factors (M.G. Newman, P. Crits‐Christoph, M.B. Connelly Gibbons, & T.M. Erickson, 2006), and relationship factors (W.B. Stiles & B.E. Wolfe, 2006), which are related to anxiety disorder treatment outcome. The authors then place these factors and their practice implications within a common framework. Their integration is based on (a) the concept of appropriate responsiveness, and (b) a distinction between actions and achievements. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 649–659, 2006.
Immature dependence and self‐criticism predict the recurrence of major depression
Authors: Mongrain Myriam , Leather Faith 
Published: March 2006

AbstractThis research examined the associations of unipolar depression with immature dependence and self‐criticism (S.J. Blatt et al., 1995) in a sample of graduate students with a diagnosed history of depression. A battery of tests was completed by 158 students, and a subset (n =102) was reached approximately 20 months later for the assessment of new depressive onsets. Self‐criticism and neuroticism were uniquely associated with a past history of depression, and self‐criticism and immature dependence interacted in predicting past occurrences of depression. Self‐criticism was increasingly associated with past depressive episodes as level of immature dependence increased. The interaction of immature dependence and self‐criticism was also evident in predicting future occurrence of depression after controlling statistically for the effects of current symptoms, neuroticism, certain Axis II diagnoses, and number of previous depressive episodes. This interactive effect suggests that individuals with high levels of both self‐criticism and immature dependence are particularly prone to depressive episodes. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 705–713, 2006.
Effects of a group forgiveness intervention on forgiveness, perceived stress, and trait‐anger
Authors: Harris Alex H. S. , Luskin Frederic , Norman Sonya B. , Standard Sam , Bruning Jennifer , Evans Stephanie , Thoresen Carl E. 
Published: March 2006

AbstractThe goal of this study was to evaluate the effects of a 6‐week forgiveness intervention on three outcomes: (a) offense‐specific forgiveness, (b) forgiveness‐likelihood in new situations, and (c) health‐related psychosocial variables, such as perceived stress and trait‐anger. Participants were 259 adults who had experienced a hurtful interpersonal transgression from which they still felt negative consequences. They were randomized to a forgiveness‐training program or a no‐treatment control group. The intervention reduced negative thoughts and feelings about the target transgression 2 to 3 times more effectively than the control condition, and it produced significantly greater increases in positive thoughts and feelings toward the transgressor. Significant treatment effects were also found for forgiveness self‐efficacy, forgiveness generalized to new situations, perceived stress, and trait‐anger. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 715–733, 2006.