bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Route to Regioselectively Functionalized Carbazoles, Dibenzofurans, and Dibenzothiophenes Through Anionic Cyclization of Benzyne‐Tethered Aryllithiums.
Authors: Sanz Roberto , Fernandez Yolanda , Castroviejo Ma. Pilar , Perez Antonio , Fananas Francisco J. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 2,4‐Disubstituted 5‐Aminoimidazoles Using Microwave Irradiation.
Authors: Soh Chai Hoon , Chui Wai Keung , Lam Yulin 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Synthesis of 2‐Substituted Imidazoles by Palladium‐Catalyzed Cross‐Coupling with Benzylzinc Reagents.
Authors: Utas Josefin E. , Olofsson Berit , Aakermark Bjoern 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Simple KHSO4‐Promoted Synthesis of 2‐Arylsubstituted Benzimidazoles by Oxidative Condensation of Aldehydes with o‐Phenylenediamine.
Authors: Ma Huiqiang , Wang Yulu , Wang Jinye 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Combinatorially Convenient Version of Synthesis of 5‐Substituted Oxazole‐4‐carboxylic Acid Ethyl Esters.
Authors: Tormyshev V. M. , Mikhalina T. V. , Rogozhnikova O. Yu. , Troitskaya T. I. , Trukhin D. V. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rearrangement of Cyclic Dithiocarbamates.
Authors: Trofimova T. P. , Pushin A. N. , Lys Ya. I. , Fedoseev V. M. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tandem Azidination— and Hydroazidination—Huisgen [3 + 2] Cycloadditions of Ynamides. Synthesis of Chiral Amide‐Substituted Triazoles.
Authors: Zhang Xuejun , Hsung Richard , You Linfeng 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cerium(IV) Ammonium Nitrate (CAN): A Very Efficient Reagent for the Synthesis of Tertiary Ethers.
Authors: Alvarez‐Manzaneda E. J. , Chaboun R. , Alvarez E. , Cabrera E. , Alvarez‐Manzaneda R. , Haidour A. , Ramos J. M. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Aza‐Wittig Reactions: Enantioselective Synthesis of β‐Quaternary Azacycles.
Authors: Lertpibulpanya Duanpen , Marsden Stephen P. , Rodriguez‐Garcia Ignacio , Kilner Colin A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Light‐Induced Iminyl Radical Cyclization Reactions of Acyloximes to Isoquinolines.
Authors: Alonso Rafael , Campos Pedro J. , Garcia Barbara , Rodriguez Miguel A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Spirocyclic Benzo[f]quinoline Derivatives by Cascade Heterocyclization of Dimedone, 2‐Naphthylamine, and Formaldehyde.
Authors: Kadutskii A. P. , Kozlov N. G. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Liquid‐Phase Parallel Synthesis of Combinatorial Libraries of Substituted 6‐Carbamoyl‐3,4‐dihydro‐2H‐benzo[1,4]thiazines.
Authors: Trifilenkov Andrey S. , Kobak Vladimir V. , Salina Marina A. , Kusovkova Julya A. , Ilyin Alexey P. , Khvat Alexander V. , Tkachenko Sergey E. , Ivachtchenko Alexandre V. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Condensed Tetrazolo‐1,3,5‐triazines. Part 3. Synthesis of 3‐R‐5‐Trinitromethyltetrazolo[1,5‐a]‐1,3,5‐triazin‐7‐ones.
Authors: Bakharev V. V. , Gidaspov A. A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Practical and Efficient Palladium‐Promoted Synthesis of Indole Systems Containing Medium‐ and Large‐Ring‐Fused Heterocycles.
Authors: Beccalli Egle M. , Broggini Gianluigi , Martinelli Michela , Paladino Giuseppe , Rossi Elisabetta 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lanthanoids in Organic Synthesis. Part 6. Diastereoselective Addition of Organocerium(III) Reagents Derived from 3‐Substituted Propargyl Bromides to Aldehydes.
Authors: Groth Ulrich , Kesenheimer Christian , Neidhoefer Juergen 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
[Pd(Ar‐BIAN)(alkene)]‐Catalyzed Highly Chemo‐, Regio‐, and Stereoselective Semihydrogenation of 1,2‐Allenyl Phosphonates and Related Compounds.
Authors: Guo Hao , Zheng Zilong , Yu Fei , Ma Shengming , Holuigue Alexandre , Tromp Dorette S. , Elsevier Cornelis J. , Yu Yihua 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient Method for the Synthesis of 2,5‐Difunctionalized Phospholes Bearing Ester Groups.
Authors: Matano Yoshihiro , Miyajima Tooru , Nakabuchi Takashi , Matsutani Yuichiro , Imahori Hiroshi 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selenium‐Containing Heterocycles from Isoselenocyanates: Use of Hydrazine for the Synthesis of 1,3,4‐Selenadiazine Derivatives (III).
Authors: Sommen Geoffroy L. , Linden Anthony , Heimgartner Heinz 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sinularianins A and B, Novel Sesquiterpenoids from the Formosan Soft Coral Sinularia sp.
Authors: Chao Chih‐Hua , Hsieh Chi‐Hua , Chen Shin‐Pin , Lu Chung‐Kuang , Dai Chang‐Feng , Sheu Jyh‐Horng 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two New ent‐Kaurane Diterpenoids from Isodon Macrophyllus.
Authors: Zhang Ji Xia , Chen Zheng Yue , Wang Yong Xue , Qiu Pei Yong , Huang Sheng Xiong , Sun Han Dong 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Construction of the Clerodane Decalin Core by an Asymmetric Morita—Baylis—Hillman Reaction/Lewis Acid Promoted Annulation Strategy.
Authors: Rodgen Stacy A. , Schaus Scott E. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Enantioselective Synthesis of Condensed and Aromatic‐Ring‐Substituted Tyrosine Derivatives.
Authors: Knoer Sebastian , Laufer Burkhardt , Kessler Horst 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Synthesis of Sugar Iminopyrrolidine Derivatives via an Intramolecular Staudinger—Aza‐Wittig‐Type Reaction.
Authors: Ducatel Helene , Nguyen Van Nhien Albert , Pilard Serge , Postel Denis 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phosphomolybdic Acid Supported on Silica Gel: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2,3‐Unsaturated Glycopyranosides by Ferrier Rearrangement.
Authors: Yadav J. S. , Satyanarayana M. , Balanarsaiah E. , Raghavendra S. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Accessing Tetrahydrofuran‐Based Natural Products by Microbial Baeyer—Villiger Biooxidation.
Authors: Mihovilovic Marko D. , Bianchi Dario A. , Rudroff Florian 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Explicit Diversity Index (EDI): A Novel Measure for Assessing the Diversity of Compound Databases.
Authors: Papp Akos , Gulyas‐Forro Anna , Gulyas Zsolt , Dorman Gyoergy , Uerge Laszlo , Darvas Ferenc 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Characterization of DNA Primary Sequences by a New Similarity/Diversity Measure Based on the Partial Ordering.
Authors: Todeschini R. , Consonni V. , Mauri A. , Ballabio D. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Do the Neighboring Residues in a Polypeptide Affect the Electron Distribution of an Amino Acid Significantly? A Quantitative Study Using the Quantum Theory of Atoms in Molecules (QTAIM).
Authors: Lorenzo Luis , Gonzalez Mao Maria J. , Mandado Marcos , Mosquera Ricardo A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Comparative Analysis of Binding Energy of Chymostatin with Human Cathepsin A and Its Homologous Proteins by Molecular Orbital Calculation.
Authors: Yoshida Tatsusada , Lepp Zsolt , Kadota Yoshio , Satoh Yurie , Itoh Kohji , Chuman Hiroshi 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Parallel Screening: A Novel Concept in Pharmacophore Modeling and Virtual Screening.
Authors: Steindl Theodora M. , Schuster Daniela , Laggner Christian , Langer Thierry 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Absolute Net Charge and the Biological Activity of Oligopeptides.
Authors: Parthasarathi Laavanya , Devocelle Marc , Soendergaard Chresten , Baran Ivan , O'Dushlaine Colm T. , Davey Norman E. , Edwards Richard J. , Moran Niamh , Kenny Dermot , Shields Denis C. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Carbon‐Coated Core Shell Structured Copper and Nickel Nanoparticles Synthesized in an Ionic Liquid.
Authors: Jacob Davis S. , Genish Isaschar , Klein Lior , Gedanken Aharon 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Complex Rare‐Earth Tetrelides, RE5(SixGe1‐x)4: New Materials for Magnetic Refrigeration and a Superb Playground for Solid State Chemistry
Authors: Miller Gordon J. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organotin—Sulfur Intramolecular Interactions: Overview of Current and Past Compounds and the Biological Implications of Sn—S Interactions
Authors: Munguia Teresita , Cervantes‐Lee Francisco , Parkanyi Laszlo , Pannell Keith H. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1,3‐Dithiole‐2‐thiones and Tetrathiafulvalenes Using Oligo(1,3‐dithiole‐2,4,5‐trithione)
Authors: Abashev G. G. , Shklyaeva E. V. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A recombinant human RNASET2 glycoprotein with antitumorigenic and antiangiogenic characteristics
Authors: Smirnoff Patricia , Roiz Levava , Angelkovitch Boaz , Schwartz Betty , Shoseyov Oded 
Published: November 2006

AbstractBACKGROUND.Human RNASET2 is a T2‐RNase glycoprotein encoded by the RNASET2 gene, which is located on chromosome 6 (6q27). Deletion in 6q27 is associated with several human malignancies.BACKGROUND.A synthetic RNASET2 gene that was optimized for expression in the yeast Pichia pastoris was designed according to the cDNA sequence and was cloned under the control of the methanol‐induced promoter fused to the α‐mating secretion peptide. The recombinant protein was purified from the culture supernatant of transformed P. pastoris through an affinity Sepharose‐concanavalin A column. Actin‐binding activity was examined by membrane blotting using monoclonal mouse antiactin immunoglobulin M and by cross‐linking in solution to G‐actin using 1‐[3‐(dimethylamino)propyl]‐3‐ethyl‐carboimide methiodide. The antiangiogenic activity of RNASET2 (from 0.5 μM to 10 μM) was assessed by a human umbilical vein endothelial (HUVE) cell assay in the presence of 1 μg/mL angiogenin, basic fibroblast growth factor (bFGF), or recombinant human vascular endothelial growth factor (VEGF). Cell colony formation was examined in human colon HT29 cancer cells to assess the antitumorigenic activity of RNASET2 or the enzymatic‐inactivated RNASET2 (EI‐RNASET2) (1 μM each). In an athymic mouse xenograft model, LS174T human cancer cells were injected subcutaneously. When tumors were palpable, the mice were treated for 3 weeks with RNASET2 (1 mg/kg), paclitaxel (10 mg/kg or 15 mg/kg), or a combination of the 2 drugs.RESULTS.The recombinant RNASET2 was identified as a 27‐kilodalton glycoprotein that possessed the ability to bind actin in vitro. RNASET2 significantly inhibited clonogenicity in HT29 cells. EI‐RNASET2 produced a similar effect, suggesting that its antitumorigenic activity is unrelated to its RNase activity. In HUVE cells, RNASET2 inhibited angiogenin‐, bFGF‐, and VEGF‐induced tube formation in a dose‐dependent manner. In athymic mice, RNASET2 inhibited the development of an LS174T‐derived xenograft by 40%. A synergistic effect was obtained with combined RNASET2 and paclitaxel treatments.CONCLUSIONS.The current results suggested that RNASET2 represents a new class of antitumorigenic and antiangiogenic drugs, and the findings of this study emphasize the advantage of using agents like RNASET2 in combined therapy. Cancer 2006. © 2006 American Cancer Society.
Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis
Authors: Maertens Johan , Glasmacher Axel , Herbrecht Raoul , Thiebaut Anne , Cordonnier Catherine , Segal Brahm H. , Killar John , Taylor Arlene , Kartsonis Nicholas , Patterson Thomas F. ,   Caspofungin Combination Therapy Study Group
Published: November 2006

AbstractBACKGROUND.Caspofungin inhibits synthesis of β‐1,3‐glucan, an essential component of the Aspergillus cell wall. This echinocandin has demonstrated efficacy (45% success) as salvage monotherapy of invasive aspergillosis (IA). Interest remains as to whether caspofungin, in combination with other antifungal classes, can improve the efficacy against IA.METHODS.The study involved 53 adults with documented IA who were refractory to or intolerant of standard antifungal therapy and received caspofungin and 1 other mold‐active antifungal agent (at the investigator's discretion). Efficacy was assessed by signs, symptoms, and radiographs at the end of combination therapy and Day 84 after combination therapy initiation. Favorable (complete or partial) responses required significant clinical and radiographic improvement. Diagnoses and outcomes were assessed by an independent expert.RESULTS.Among the 53 patients enrolled the most common underlying diseases were acute leukemia (53%), lymphoma (11%), and chronic leukemia (6%). Pulmonary aspergillosis (81%) was the most common site, and most patients (87%) were refractory to prior therapy. Success at the end of combination therapy and Day 84 was 55% (29/53) and 49% (25/51), respectively. Fifty‐seven percent of patients with neutropenia and 54% who received an allogeneic hematopoietic stem cell transplant responded favorably. Survival at Day 84 was 55%. Combination therapy, dosed on average for 31.3 days, was well tolerated. Two (4%) serious drug‐related adverse events, both attributed to voriconazole, occurred. None of the patients discontinued caspofungin due to toxicity.CONCLUSIONS.Caspofungin in combination with a triazole or polyene was an effective alternative as salvage therapy for patients with recalcitrant Aspergillus infections. Cancer 2006. © 2006 American Cancer Society.
Cisplatin and gemcitabine with either vinorelbine or paclitaxel in the treatment of carcinomas of unknown primary site
Authors: Palmeri Sergio , Lorusso Vito , Palmeri Laura , Vaglica Marina , Porta Camillo , Nortilli Rolando , Ferraú Francesco , Comella Giuseppe , Massidda Bruno , Danova Marco 
Published: November 2006

AbstractBACKGROUND.To date, the standard treatment for patients who have carcinoma of unknown primary site has not been established.METHODS.In this randomized Phase II study, 66 previously untreated patients (33 patients per arm) with carcinomas of unknown primary site received cisplatin (35 mg/m2) and gemcitabine (1000 mg/m2) with either paclitaxel (70 mg/m2) or vinorelbine (25 mg/m2), and all drugs were administered intravenously on Days 1 and 8 of a 21‐day cycle. Twenty‐nine patients (44%) presented with ≥2 involved sites. The pathologic diagnosis was mainly adenocarcinoma (48 patients; 72.7%) and squamous carcinoma (7 patients; 10.6%).RESULTS.In the first arm, 16 patients (48.5%) experienced an objective response, and 9 patients (27.2%) had disease stabilization. In the vinorelbine‐containing arm, 14 patients (42.3%) experienced an objective response, and 8 patients (24.2%) had disease stabilization. The median response duration and the median time to progression were similar in both treatment arms; the median overall survival was 9.6 months (95% confidence interval, 7.11–12.09 months) for patients who received the cisplatin/gemcitabine/paclitaxel regimen and 13.6 months (95% confidence interval, 6.61–20.59 months) for patients who received the vinorelbine combination. Grade 3 and 4 toxicities were more frequent in the paclitaxel‐containing arm.CONCLUSIONS.Both combinations satisfied the 2‐step design, demonstrating antitumor activity without relevant differences in response rates or response duration; however, the vinorelbine‐containing regimen yielded superior results both in terms of overall survival (13.6 months vs 9.6 months) and in terms of treatment tolerability. Therefore, according to a pick the winner attitude, the combination of cisplatin/gemcitabine/vinorelbine may be considered in the design of future randomized, Phase III trials for patients with carcinomas of unknown primary site. Cancer 2006. © 2006 American Cancer Society.
High‐dose therapy and autologous stem‐cell transplantation can improve event‐free survival for indolent lymphoma
Authors: Vignot Steéphane , Mounier Nicolas , Larghero Jeérôme , Brice Pauline , Quero Laurent , de Bazelaire Ceédric , Ertault Marjan , Brière Josette , Madelaine Isabelle , Gisselbrecht Christian 
Published: November 2006

AbstractBACKGROUND.High‐dose therapy (HDT) and autologous stem‐cell transplantation (ASCT) remain controversial for indolent lymphoma patients.METHODS.The study was designed to evaluate the benefit of this strategy by retrospectively comparing for each patient the event‐free survival (EFS) after ASCT with the duration of the disease phase just before the phase including ASCT (ie, the last qualifying phase, LQP).RESULTS.A total of 109 indolent lymphoma (mostly follicular lymphoma) patients were treated with HDT and ASCT. Before ASCT, patients experienced a median of 2 disease phases (range, 1–4). After a median 5‐year follow‐up from ASCT, overall survival was 67% and EFS was 43%. When each of the 92 patients experiencing recurrence was taken as her/his own control, EFS was longer after ASCT than the duration of LQP (62%, P < .01). During LQP, 86 patients (93%) experienced recurrence in less than 5 years, compared with only 58 (63%) who experienced recurrence in the 5 years after ASCT (P < .01).CONCLUSION.HDT and ASCT can significantly increase EFS in comparison with the duration of the LQP for indolent lymphoma patients and can change disease course. This methodology has been found useful for evaluating new strategies, especially with monoclonal antibodies. Cancer 2007. © 2006 American Cancer Society.