bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rubidium‐86 uptake by red blood cells of breast cancer patients
Authors: Telfer Nancy , Lee Yeu‐Tsu N. , Merrill Quenious , Bauer Franz K. 
Published: February 2007

AbstractThe red blood cell (RBC) uptake of rubidium‐86 (Rb‐86), a sensitive in vitro test of RBC membrane transport, was measured in 22 controls, 8 patients with benign breast lesions, and 30 stage I/II, 13 stage III/IV untreated breast cancers. Total Rb‐86 transport was measured. Following ouabain block, passive transport was determined, allowing calculation of active Rb‐86 uptake by difference.There was a significant decrease in total and passive uptake by RBCs from patients with breast cancer when compared to controls and those with benign lesions (total uptake 58.6 ± 6.1% versus 63.6 ± 3.9%, P < 0.01; passive uptake 38.7 ± 6.8% versus 42.7 ± 4.6%, P < 0.02). The Rb‐86 uptake returned towards normal in successfully treated stages‐II‐to‐IV patients. There were no correlations with the patient's age, hematocrit, or incubation hematocrit with RBC Rb‐86 uptakes. Results from incubation in Krebs‐Ringer solution were not consistent with a plasma blocking factor. The RBC potassium content was slightly increased in the cancer patients. This, along with decreased passive transport, eliminates the nonspecific malfunction of the Na‐K‐pump as an explanation, and suggests that the decreased uptake is a cancer‐related phenomenon.
Malignant fibrous histiocytoma: A retrospective evaluation of 24 patients
Authors: Tewfik H. H. , Tewfik F. A. , Latourette H. B. 
Published: February 2007

AbstractTwenty‐four patients with malignant fibrous histiocytoma are being analyzed: 54.2% occurred in the sixth, seventh, and eighth decades of life; 45.8% were located in the extremities. This is a soft tissue sarcoma noted for its pleomorphic histologic appearance. It is postulated that the origin cell is a histiocyte. The local recurrence or metastatic potential of this tumor is difficult to predict from its histological features. Local recurrence after complete excision is frequent. Also, there is a high incidence of distant metastases. Wide local excision with a wide margin around the tumor is the most important treatment modality. The use of postoperative radiotherapy and chemotherapy needs to be evaluated.
Urinary immunoglobulin A in the diagnosis of bladder cancer
Authors: Betkerur V. , Baumgartner G. , Talluri K. , Sharifi R. , Nagubadi S. , Guinan P. 
Published: February 2007

AbstractUrinary immunoglobulin A levels were measured in the urine of 13 patients with histologically diagnosed bladder cancer present, six patients with culture proven urinary tract infection, and 14 control individuals. There were statistically significantly higher immunoglobulin A levels in the urine of patients with bladder cancer than in either individuals with urinary tract infection or control individuals. Urinary immunoglobulin A may be a potentially useful test for the diagnosis and follow‐up of bladder cancer patients.
Solitary lung nodule due to dirofilaria immitis (dog “heartworm”)
Authors: Darrow John C. , Lack Ernest E. 
Published: February 2007

AbstractThe filarial parasite Dirofilaria immitis (dog “heartworm”) is the cause of a progressive zoonosis among canine species in the United States; it is rarely transmitted to man, in whom it can present as a solitary lung nodule. There are currently no reliable clinical or radiologic features to distinguish it from other solitary necrotizing granulomas, and thoracotomy is currently the only means of establishing the diagnosis. D. immitis can be identified and properly classified by routine light microscopy despite being immature and partially necrotic. Canine Dirofilariasis may well assume even greater medical importance because of its expanding geographic range and the concomitant increase in the number of cases observed among humans.
Surgery of hyperparathyroidism: A conservative approach
Authors: Wang Chiu‐An 
Published: February 2007

AbstractThe extent of surgery in the treatment of primary hyperparathyroidism should be based on the pathologic entity of the disease. In neoplasia (either the common adenoma or the rare carcinoma), excision of the diseases parathyroid will generally suffice to cure the disease, but in primary hyperplasia, the removal of all the diseased glands except for a small amount of glandular tissue is required. The pathologic diagnosis of primary hyperparathyroidism can usually be made by a macroscopic assessment of the parathyroid. It is further delineated by the density test and confirmed by Sudan fat‐frozen section examination.
Diagnostic studies of thyroid cancer
Authors: Rosen Irving B. 
Published: February 2007

AbstractPatient with goiter usually has benign disease. While investigation is important, clinical factors weigh heavily in the diagnosis of cancer. Aside from serum calcitonin and CEA, biochemical findings are of little help. Radioisotope scanning is of fundamental importance and has an implication in histology. Ultrasonography has a diminishing role although its use has led to the widespread acceptance of needle aspiration. Needle aspiration cytology is now the most important maneuver in preoperative assessment and management of the goiter patient. Its results permit refined operative selection, the institution of safe conservative management, and greater organization in surgical treatment. Persistent cooperation between clinician and pathologist can yield a high rate of reliable preoperative cytological diagnosis obtained by needle aspiration.
Subtotal parathyroidectomy: Normalization of circulating parathormone
Authors: Paloyan Edward , Lawrence A. M. , Oslapas Raymond , Ernst Kazuko , Ahearn Mary Beth , Bellar Barbara 
Published: February 2007

AbstractSubtotal parathyroidectomy was performed in 52 consecutive patients with primary hyperparathyroidism. The postoperative results, 6–24 months following the operation, were evaluated according to a calcium‐parathormone normogram. In 48 patients the values returned to the normal zone. Two patients had persistent hypercalcemia. The other two patients remained in the hyperparathyroid zone of the normogram, with moderate elevations of serum parathormone, in spite of normocalcemia. The significance of the failure to achieve normal circulating parathormone levels in patients with postoperative eucalcemia is discussed. The importance of serum parathormone and calcium relationship in the evaluation of patients following parathyroidectomy is emphasized.
Gastrostomy and oesophagoplasty with a flap from the greater curvature of the stomach as stages of surgical and combined treatment of cancer of the thoracic oesophagus
Authors: Pirogov A. , Mamontov A. , Ryndin V. 
Published: February 2007

AbstractFour‐hundred fifty‐eight patients with cancer of the oesophagus were subjected to revisional laparotomy. Metastases into subphrenic lymph nodes were registered in 24% of the cases with a tumor in the bronchial segment; 42% with tumor in the subbronchial segment; 48% with tumor in the retropericardial segment; 71% with tumors in the sub‐, intra‐, and supraphrenic segments of the oesophagus. In 345 cases, laparotomy was followed by tube gastrostomy (Beck—Carrel method) with two operative deaths. Fifty‐six patients in good condition with a small tumor in the middle part of the oesophagus (≤5 cm) without any abdominal metastases were subjected to primary oesophagoplasty: a 30–32‐cm tube was formed out of the greater curvature of the stomach and placed retrosternally; gastrostomy was performed on the level of the thyroid cartilage (without any operative deaths). In two weeks, extirpation of the thoracic part of the oesophagus (with preoperative irradiation) was performed on patients with no abdominal metastases. Then the patients with primary oesophagoplasty were subjected to oesophago‐gastrostomy of the neck. From six to 12 months following the combined treatment, the gastrostomy tube of 45 patients was lengthened to 30–32 cm and used for retrosternal oesophagoplasty (six operative deaths). Oesophagoplasty was performed on 14 patients during the extirpation of the oesophagus (six operative deaths).
Association of insulinoma with subcutaneous nodular fat necrosis
Authors: Schwartz Robert Allen , Fleishman Jay S. 
Published: February 2007

AbstractA 57‐year‐old man first noted tender subcutaneous nodules on his extremities and abdomen. Six months later symptoms of insulin hypersecretion became evident and hyperinsulinemia was documented. An exploratory laparotomy revealed an islet cell tumor measuring 12 cm in diameter extending anteriorly from head of the pancreas with metastases in the liver. Evidence of parathyroid and pituitary hormone hypersecretion suggests that the insulinoma may be part of a multiple endocrine neoplasia syndrome. Histological examination of the subcutaneous nodules revealed the characteristic histology of nodular fat necrosis. This is the first report of the association of an insulin‐secreting islet cell carcinoma with subcutaneous nodular fat necrosis.
Carcinoma in choledochal cyst
Authors: Gupta Saroj , Kumar Anand , Gupta Sudarshan K. , Gupta Saroj 
Published: February 2007

AbstractTwo cases of choledochal cyst associated with adenocarcinoma are documented. The classical triad of jaundice, abdominal mass, and pain is not distinctive enough to make the preoperative diagnosis of a choledochal cyst and its associated malignancy. Operative cholangiogram is a very important investigation, as by the presence of a filling defect in the cyst it can suggest malignancy. In our cases the diagnosis of malignancy was made at operation, which was confirmed by histopathological examination. Internal drainage procedures in combination with chemotherapy by 5 FU rendered both the cases asymptomatic.
Combination chemotherapy in a prostate tumor model: Nb rat prostatic adenocarcinoma model
Authors: Drago Joseph R. , Worgul Thomas , Gershwin M. Eric 
Published: February 2007

AbstractThis report presents the experience with single and combination chemotherapy in the Noble rat prostatic adenocarcinoma model. The best single agent in treatment of these tumors is cyclophosphamide, the best combination was triple drug therapy cyclophosphamide, cis‐plati‐num, and adriamycin. This report examines the effect of the various chemotherapeutic regimens on tumor volume, number of metastasis, and complete tumor regression.
Malignant melanoma of the female genital system: A report of 48 patients and review of the literature
Authors: Ariel Irving M. 
Published: February 2007

AbstractMalignant melanoma of the female genital tract comprises 3% of all melanomas afflicting females. Melanoma of the vulva is most common, comprising 45 patients treated by the author. Thirty‐two percent had metastases to the regional lymph nodes on presentation. Five‐year survival is 31.6%. Radical vulvectomy and radical groin dissection is the treatment of choice. Only 80 melanomas of the vagina have been reported, with cures being an extreme rarity. Forty cases of the female urethra reported in the literature and only five survivors have been reported. Melanoma of the uterus is extremely rare, with no cures recorded. Melanoma of the ovary may occur within a teratoma but most frequently is metastatic.
Cancer to the inguinal nodes from an unknown primary site
Authors: Wallack Marc K. , Reynolds Barbara 
Published: February 2007

AbstractThree cases of metastatic cancer to inquinal lymph nodes from unknown primaries are presented. All three patients had exhaustive workups which produced no primary lesions. There were two cases of metastatic squamous cell carcinoma and one of melanoma. A review of the literature shows that it is unusual to have metastatic disease without detectable primary lesions to the inguinal lymph nodes. Furthermore, and more importantly, these cases open discussion of recent concepts of tumor biology. Based on these newer concepts, suggestions are made concerning the examination and treatment of these unusual lesions.
Heterotopic ossification in a lymph node with metastatic follicular carcinoma of thyroid: A case report
Authors: Wasiljew Bohdan K. , Apostol James V. , Rao M. Sambasiva 
Published: February 2007

AbstractMetastasis of follicular thyroid carcinoma in a cervical lymph node associated with heterotopic ossification in a 34‐year‐old white female is presented. Pertinent gross and microscopic pathology is described and the literature is reviewed briefly. Bone formation in thyroid neoplasm has not been reported previously, except for bone metastases of medullary carcinoma.
The antigenicity of synchronous cancers of the colon and rectum
Authors: Greco Ralph S. 
Published: February 2007

AbstractImmuno‐reactivity to tumor extracts in patients with colorectal cancer was evaluated by the direct leukocyte migration inhibition assay. Hypertonic potassium chloride extracts were prepared from a group of synchronous colorectal cancers and from single colorectal cancers. Both groups of extracts were tested in patients with single colorectal cancers. All patients were tested preoperatively, none were previously treated, and none had distant metastases. Synchronous extracts showed no significant migration inhibition in allogeneic assays. Single colorectal cancers showed highly significant inhibition to autologous extracts only and not to allogeneic extracts. These data support the contention that colorectal cancers are antigenically dissimilar.
Osteoclastome‐like giant cell thyroid carcinoma controlled by intensive radiation and adriamycin, in a patient with meningioma and multiple myeloma treated by radiation and cytoxan
Authors: Vizel–Schwartz Monique 
Published: February 2007

AbstractThe eighth case of osteoclastome‐like giant cell carcinoma of the thyroid, and the first one to be treated with adriamycin in addition to surgery and radiation, is reported. This rare variant of anaplastic thryoid carcinoma appeared in a patient operated on for meningioma and treated for multiple myeloma with cranial radiation and chronic administration of cytoxan.
Immunological detection of metastases from prostatic adenocarcinoma
Authors: Heaney John A. , Lin Julia C. , Daly James J. , Prout George R. 
Published: February 2007

AbstractIn six patients with known prostatic adenocarcinoma, extraprostatic (metastatic) tumor was suspected on radiographic or radionucleotide studies. When cytological examination of tissue obtained by needle aspiration or biopsy was nondiagnostic, radial gel immunodiffusion was used to identify the presence of prostatic acid phosphatase in the tissue. Four specimens demonstrated prostate‐specific acid phosphatase activity, permitting the diagnosis of metastatic prostatic adenocarcinoma. The technique is simple and highly specific.
Current report on the interferon program at Roswell Park Memorial Institute
Authors: Murphy Gerald P. 
Published: February 2007

AbstractAn overview of the interferon program at Roswell Park Memorial Institute (RPMI), is presented. This program encompasses three interrelated areas of research and new drug development: (a) basic research on purification and characterization of animal and human interferons (leukocyte, fibroblast, and immune); (b) large scale manufacture and preclinical testing of human fibroblast interferon (HFIF); and (c) clinical trials with HFIF to determine its safety of administration as well as antiviral, antitumor, and immunomodulatory activities in patients with neoplastic or viral disease. The antitumor effect of HFIF produced at RPMI as assessed by intralesional injection of various metastatic nodules resulted in an overall 71% local response. Phase I studies in 13 patients demonstrated that HFIF can be administered safely by the subcutaneous, intramuscular, and intravenous routes in doses up to 25 million units per day without any serious untoward effects. Intrathecal administration of HFIF into patients with CNS leukemia was also well tolerated. Pharmacokinetic studies indicated significant levels of HFIF in serum and cerebrospinal fluid after intravenous and intrathecal administration, respectively. Coincidental with the HFIF systemic administration during the Phase I trials, favorable responses in several laboratory, immune, and clinical parameters were observed. These results provide the rationale for conducting phase II and phase III clinical trials with HFIF produced at RPMI.
Prostate cancer mortality among catholic priests
Authors: Michalek Arthur M. , Mettlin Curtis , Priore Roger L. 
Published: February 2007

AbstractTo investigate the possible role of celibate lifestyles in the etiology of prostate cancer, analyses of mortality from cancers of the prostate and other sites among an average annual cohort of 6,226 Roman Catholic clergymen in New York State from 1965 through 1977 were conducted. The death certificates of 1006 (95%) priests were reviewed. Of these 156 deaths were attributable to malignant neoplasms. Clerics experienced mortality ratios of 15% less for all causes of death and 30% less for cancer mortality, given mortality patterns among New York State white males of comparable ages. Twelve deaths from prostatic cancer were observed while 19.8 were expected. This represents a mortality experience significantly less than that of the general noncelibate population. Lower mortality ratios were found also for cancers of the lung, colo‐rectum, and stomach. Higher mortality ratios were found for malignant melanoma and unspecified respiratory organs.
Effect of cimetidine on human leukocyte function
Authors: Majeski James A. , Alexander J. Wesley 
Published: February 2007

AbstractIn vitro studies of the effects of cimetidine on neutrophil and monocyte chemotaxis revealed no differences between the treated cells and control cells. In vitro studies were performed on neutrophils and monocytes from 20 patients who were treated with oral cimetidine for duodenal ulcer disease. Neutrophil studies from these patients revealed no effect by cimetidine. A significant augmentation of chemotaxis was found in monocytes from patients receiving the drug. Studies of neutrophil phagocytosis from cimetidine‐treated patients were exactly identical to control values. These studies indicate cimetidine to have a stimulatory effect on monocyte chemotaxis and no effect on neutrophil function.
Cystic lymphangioma of stomach and jejunum: Report of one case
Authors: Colizza S. , Tiso B. , Bracci F. , Cudemo R. G. , Bigotti A. , Crisci E. 
Published: February 2007

AbstractA case of cystic lymphangioma of stomach and jejunum is reported. The patient, a woman aged 58, was referred to the hospital for a melena of 4 days duration, which was interpreted as related to an old history of hypertrophic gastritis and duodenal ulcer. A conservative treatment with transfusions, cimetidine i.v., and gastric washout with antacids was started, but the hemorrhage appeared unresponsive, so an explorative laparotomy was performed. At the operation a soft pliable cystic mass in the anterior wall of the stomach was found; a smaller one was felt in the second jejunal loop. A Billroth II gastroduodenal resection was performed. The diagnosis of nature was only microscopic. At 9 months follow‐up the patient is well, free of the disease.
Delayed hypersensitivity reactions vs chemotherapy and immunotherapy responses in women with ovarian adenocarcinoma
Authors: Piver M. Steven , Blumenson Leslie , Barlow Joseph J. , Senko Reggie 
Published: February 2007

AbstractFifty‐one previously untreated women with FIGO Stages III and IV ovarian adenocarcinoma underwent sequential monthly skin testing utilizing Keyhole Limpet Hemocyanian, Varidase, mumps, monilia, and a purified protein derivative Tuberculin (PPD) prior to each course of systemic chemotherapy (with or without Corynebacterium parvum). The purpose of the study was to evaluate the patients' ability to demonstrate a delayed cutaneous hypersensitivity reaction to these sensitizing antigens and response to therapy. There was no statistically significant correlation with response to therapy and: 1) Positive pretherapy skin test reactions vs anergy to pretherapy skin tests. 2) Negative pretherapy and positive post‐therapy skin tests. 3) Anergy pre‐ and post‐therapy vs positive skin tests pre‐ or post‐therapy. 4) Age of the patient vs skin test reactivity. 5) Skin test reactivity to any one of the five antigens tested. 6) Skin test reactivity in response to therapy in those women also receiving Corynebacterium parvum. It is concluded that the battery of skin tests utilized do not predict the patient's response to systemic chemotherapy in advanced ovarian adenocarcinoma.
Effects of hepatic artery ligation and intraarterial embolization on liver tumor growth—an experimental study in rats
Authors: Carlsson G. , Ekelund L. , Hafström Lo , Jonsson N. , Stigsson L. 
Published: February 2007

AbstractThe effect of hepatic artery ligation and intraarterial embolization was investigated in rats with liver tumors. Only a temporary reduction in tumor growth was registered after both procedures as compared to controls. There was a somewhat more pronounced effect in the ligated animals then in the embolized ones. No clear cut differences in the extent of tumor necrosis could be found between the groups at the end of the experimental period.
Acute hodgkin disease masquerading as splenic abscess
Authors: Bloom R. A. , Freund U. , Perkes E. H. , Weiss Y. 
Published: February 2007

AbstractA splenic abscess was erroneously diagnosed in a 65‐year‐old patient. The diagnosis was established on clinical, radiological and ultrasonographic data. At laparotomy the spleen was markedly enlarged by tumoral tissue and contained a large cystic lesion. The histological diagnosis was typical Hodgkin disease with lymphocytic depletion.Ultrasonography adds valuable information in the diagnosis of splenic lesions. Hodgkin disease should be included in the differential diagnosis of cystic lesions detected in the spleen by this method.
Surgical treatment of locally far‐advanced lung carcinoma
Authors: Takita Hiroshi , Edgerton Francis , Conway Donna , Marabella Patrick C. , Vincent Ronald G. 
Published: February 2007

AbstractIt has been our policy to employ radical lung resection as a primary treatment whenever possible in locally far‐advanced lung cancer. In order to assess the therapeutic results, a total of 132 patients with locally far‐advanced lung cancer who had radical lung resection were reviewed. Postoperative mortality was 10%. A significant difference in survival was seen between those patients receiving no adjuvant therapy, radiation or single agent chemotherapy and those receiving cis‐platinum‐based polychemotherapy and/or immunotherapy (respective median survivals 14.25 and 25.68 months, P <0.05 Breslow test of failure rates). Aggressive surgery followed by effective adjuvant therapy in locally far‐advanced Stage III lung carcinoma appears to produce acceptable survival results.
Dimethyltriazenoimidazole carboxamide therapy of islet cell carcinoma of the pancreas
Authors: Awrich Alan E. , Peetz Michael , Fletcher William S. 
Published: February 2007

AbstractFour patients with metastatic glucagonoma and one patient with metastatic diarrheogenic islet cell carcinoma of the pancreas were treated with dimethyltriazenoimidazole carboxamide (DTIC), 250 mg/M2 daily for five days repeated every four weeks. All patients responded clinically and chemically in one or more ways by a reduction in plasma glucagon levels, improved glucose tolerance, decreased measureable tumor, weight gain, and resolution of necrolytic migratory erythema and diarrhea. This experience and other cases from the literature call for the investigation of DTIC as the initial therapy in metastatic islet cell carcinoma of the pancreas and as being of possible benefit in other tumors of neuroendocrine origin.