bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutation of SOCS2 induces structural and functional changes in mammary development
Authors: Ivanova Elitsa , Hue-Beauvais Cathy , Castille Johan , Laubier Johann , Le Guillou Sandrine , Aujean Etienne , Lecardonnel Jerome , Lebrun Laura , Jaffrezic Florence , Rousseau-Ralliard Delphine , Péchoux Christine , Letheule Martine , Foucras Gilles , Charlier Madia , Le Provost Fabienne 
Published: February 2024

ABSTRACT
Lactation is an essential process for mammals. In sheep, the R96C mutation in suppressor of cytokine signaling 2 (SOCS2) protein is associated with greater milk production and increased mastitis sensitivity. To shed light on the involvement of R96C mutation in mammary gland development and lactation, we developed a mouse model carrying this mutation (SOCS2KI/KI). Mammary glands from virgin adult SOCS2KI/KI mice presented a branching defect and less epithelial tissue, which were not compensated for in later stages of mammary development. Mammary epithelial cell (MEC) subpopulations were modified, with mutated mice having three times as many basal cells, accompanied by a decrease in luminal cells. The SOCS2KI/KI mammary gland remained functional; however, MECs contained more lipid droplets versus fat globules, and milk lipid composition was modified. Moreover, the gene expression dynamic from virgin to pregnancy state resulted in the identification of about 3000 differentially expressed genes specific to SOCS2KI/KI or control mice. Our results show that SOCS2 is important for mammary gland development and milk production. In the long term, this finding raises the possibility of ensuring adequate milk production without compromising animal health and welfare.
Αυτοαξιολόγηση σχολικής μονάδας και ηγεσία: Εμπειρίες από την ελληνική πραγματικότητα
Authors: Αρβανίτη Σωτηρία , Βασιλείου Αικατερίνη , Γεωργακοπούλου Ευθυμία , Καραπάνου Χριστίνα , Μποζιάρη Ελένη-Μαρίνα , Παπακαμμένου Σοφία , Πλαστήρα Ρόζα , Στεφανίδης Ιορδάνης , Λιακοπούλου Μαρία 
Published: February 2024

Σήμερα τα σχολεία καλούνται να αναλάβουν ένα υψηλότερο ποσοστό ευθύνης, να εγγυηθούν την ποιότητα του παρεχόμενου εκπαιδευτικού έργου. Η αποτελεσματικότητα του σχολείου συνδέεται άρρηκτα με τις ιδιαίτερες τοπικές και χρονικές συνθήκες μέσα στις οποίες λειτουργεί, αλλά και με τα υπερεθνικά κριτήρια αποτελεσματικότητας της εκπαίδευσης. Την τελευταία εικοσαετία δίνεται ιδιαίτερη έμφαση στην αυτοαξιολόγηση ως μια πρακτική βελτίωσης της αποτελεσματικότητας του παρεχόμενου εκπαιδευτικού έργου. Η αυτοαξιολόγηση, ιδανικά θα έπρεπε να έχει μια διπλή στόχευση: αφενός τη διασφάλιση της ποιότητα και αφετέρου τη βελτίωση της ποιότητας. Η εξισορρόπηση μεταξύ τοπικού και υπερεθνικού, λογοδοσίας και βελτίωσης αποτελεί μια μεγάλη πρόκληση που δημιουργεί πλήθος εντάσεων και αφήνει ένα τεράστιο περιθώριο ερμηνειών και επιλογών σε επίπεδο σχολικής μονάδας. Στο πλαίσιο αυτό είναι καθοριστικός ο ρόλος της ηγεσίας και του διευθυντή του σχολείου. Η παρούσα έρευνα εστιάζει στην αυτοαντίληψη του ρόλου των διευθυντών/ντριων και στη σύνδεση της αυτοαντίληψης και του στυλ ηγεσίας που υιοθετούν με τον τρόπο που αντιλαμβάνονται και πραγματοποιούν την διαδικασία της αυτοαξιολόγησης. Τα δεδομένα προκύπτουν από δεκαέξι ημιδομημένες συνεντεύξεις με διευθυντές/ντριες σχολείων. Από την ανάλυση και επεξεργασία των δεδομένων διαφαίνονται σημαντικές συνδέσεις μεταξύ του στυλ ηγεσίας των διευθυντών/ντριων και του τρόπου που αντιλαμβάνονται την αυτοαξιολόγηση.
Tyrosol and Hydroxytyrosol: Their Role in Cardioprotection
Authors: Guzowski Cezary , Murawska Joanna , Michalska Martyna , Winiarek Karolina , Czernicka Aleksandra , Kędziora-Kornatowska Kornelia 
Published: February 2024

Introduction: Recent research are focused on natural compounds for preventing cardiovascular diseases, with emphasis on tyrosol and hydroxytyrosol in olive oil. Cardiovascular diseases are linked to risk factors, and adopting a Mediterranean diet rich in these compounds is recognized for reducing risks. Understanding these compounds' actions may inform new strategies for preventing and treating cardiovascular diseases.
Aim: The aim of this paper is a systematic review of articles and research regarding the Role of tyrosol and hydroxytyrosol in Cardioprotection
Review methods: An systematic review of scientific literature was conducted using the following keywords: Tyrosol, hydroxytyrosol, cardioprotection, cardiovascular diseases, olive oil cardioprotective role. Thirty-four articles published until 2023 were searched and analyzed.
Abbreviated description of the state of knowledge: Tyrosol and hydroxytyrosol, prominent in olive oil, are studied for their potential cardioprotective properties. Linked to a Mediterranean diet, these compounds show promise in reducing cardiovascular disease risk. They counter oxidative stress, improve lipid profiles, and modulate inflammatory processes. Clinical studies suggest their positive impact, with tyrosol also explored as a potential anticoagulant. Ongoing research aims to uncover optimal doses and mechanisms, highlighting their significance in cardiovascular health.
Conclusions: Tyrosol and hydroxytyrosol, found in olive oil, show promise in cardioprotection by combating oxidative stress, improving lipid profiles, and modulating inflammation. Clinical studies suggest their positive impact on cardiovascular health. Tyrosol has potential as a anticoagulant and exhibits antioxidant effects. These compounds present a compelling avenue for future therapeutic interventions, with emphasis on understanding mechanisms and optimizing supplementation.
The Parenting Behaviours and Dimensions Questionnaire – Factor Structure and Psychometric Properties of the Polish Version
Authors: Lasota Agnieszka , Mróz Justyna 
Published: February 2024

The aim of the study was to examine the factor structure, internal consistency, and other psychometric properties of the Polish version of the Parenting Behaviours and Dimensions Questionnaire (PBDQ). In two studies, 1035 Polish parents of children between 6 months and 12 years of age completed the PBDQ, a sociodemographic questionnaire, and two measures (resilience and emotional control) to examine external validity. Exploratory and confirmatory factor analyses support a six-factor model of parenting dimensions, including emotional warmth, punitive discipline, anxious intrusiveness, autonomy support, permissive discipline, and democratic discipline. The results indicate that the Polish adaptation of the PBDQ has good reliability and validity. This measure allows for an alternative assessment of parental behaviours among Polish parents based on these positive and negative dimensions. The findings highlight the relationship between parental behaviours and other parent and child variables.
Stochastic Optimization Approaches for an Operating Room and Anesthesiologist Scheduling Problem
Authors: Tsang Man Yiu , Shehadeh Karmel S. , Curtis Frank E. , Hochman Beth R. , Brentjens Tricia E. 
Published: February 2024

Improving Operating Room, Surgery, and Anesthesiologist Scheduling Using Stochastic and Robust Optimization Efficient planning and scheduling of operating room (OR) activities is crucial for managing costs and delivering high-quality surgical care. However, this task is extremely complex for several reasons. First, it requires coordinating multiple resources, such as ORs and anesthesiologists. Second, in addition to limited OR capacity and time, there is a significant shortage of anesthesiologists required to perform surgeries. Third, surgery durations are uncertain and difficult to predict. Ignoring such uncertainty may lead to substantial overtime, idling, and surgery delays, among other schedule deficiencies. Thus, hospital managers could benefit greatly from advanced methodologies to improve OR utilization, surgical care, and quality as well as to minimize OR operational costs. In “Stochastic Optimization Approaches for an Operating Room and Anesthesiologist Scheduling Problem,” M. Y. Tsang, K. S. Shehadeh, F. E. Curtis, B.R. Hochman, and T. E. Brentjens propose computationally tractable stochastic programming and distributionally robust optimization methodologies for an integrated allocation, assignment, sequencing, and scheduling problem under uncertainty involving multiple ORs, anesthesiologists, and surgery types. Using real-world surgery data and a case study from a health system in New York, they conduct extensive experiments demonstrating the computational efficiency of the proposed methodologies, allowing for their implementation in practice. Moreover, they show the negative consequences of adopting the existing non-integrated approaches and provide valuable practical insights.
Transforming Wood into a High-Performance Engineering Material via Cellulose Nanocrystal Impregnation
Authors: Bajwa Dilpreet S. , Ara Ismat , Chan Ashton Oriel , Bajwa Sreekala G. , Hartman Kerry E. 
Published: February 2024

Abstract
The demand for wood in construction has led to shortages of strong wood types, causing a shift to costlier alternatives like concrete and nonbiodegradable materials, prompting the investigation of modifying softwoods for better engineering properties. This study investigates the optimization of a multistep impregnation process utilizing functionalized cellulose nanocrystals (f-CNCs) to enhance softwood properties. The process involves alkali delignification, ultrasonication, and vacuum pressure treatment to improve wood porosity and in turn improve CNC impregnation with uniform dispersion. Microstructural analyses through field emission scanning electron microscopy and atomic force microscopy (AFM) offer detailed insights into cell wall morphology and surface topography, whereas Fourier transform infrared spectroscopy highlights compositional shifts resulting from f-CNC impregnation. Mechanical testing demonstrates significant improvements for treated woods, particularly a 67 percent increase in modulus of elasticity for the 2 percent CNC-treated group compared with the control group; a 71 percent increase in modulus of rupture was observed for 2 percent CNC-, 3 percent NaOH-, and 2 percent acetic acid-treated group compared with the control sample. The sample delignified with 3 percent NaOH and impregnated by 2 percent f-CNC emerged as particularly effective. This research sets the stage for potential advancements in strengthening softwood using CNC, including a novel AFM method and alternative impregnation techniques like the Lowry method, inviting further exploration.
Measures of retention in HIV care: A protocol for a mixed methods study
Authors: Rehman Nadia , Garcia Michael Cristian , Jones Aaron , Ma Jinhui , Mertz Dominik , Mbuagbaw Lawrence 
Published: February 2024

Introduction
Retention in HIV care is necessary to achieve adherence to antiretroviral therapy, viral load suppression, and optimal health outcomes. There is no standard definition for retention in HIV care, which compromises consistent and reliable reporting and comparison of retention across facilities, jurisdictions, and studies.

Objective
The objective of this study is to explore how stakeholders involved in HIV care define retention in HIV care and their preferences on measuring retention.

Methods
We will use an exploratory sequential mixed methods design involving HIV stakeholder groups such as people living with HIV, people involved in providing care for PLHIV, and people involved in decision-making about PLHIV. In the qualitative phase of the study, we will conduct 20–25 in-depth interviews to collect the perspectives of HIV stakeholders on using their preferred retention measures. The findings from the qualitative phase will inform the development of survey items for the quantitative phase. Survey participants (n = 385) will be invited to rate the importance of each approach to measuring retention on a seven-point Likert scale. We will merge the qualitative and quantitative findings phase findings to inform a consensus-building framework for a standard definition of retention in care.

Ethical issues and dissemination
This study has received ethics approval from the Hamilton Integrated Research Ethics Board. The findings will be disseminated through peer-reviewed publications, conference presentations, and among stakeholder groups.

Limitations
This study has limitations; we won’t be able to arrive at a standard definition; a Delphi technique amongst the stakeholders will be utilized using the framework to reach a consensus globally accepted definition.
Anthropometric parameters as a predictor for abdominal wall thickness in a patient with gastrostomy
Authors: Mahawongkajit Prasit , Saengwijit Autchariya , Wongvisavavit Poon , Havanond Chittinad , Orrapin Saritphat 
Published: February 2024

Background
Enteral feeding tubes play essential roles in clinical management and nutritional support. Knowledge of the abdominal wall is beneficial in surgical practice and safe for gastrostomy. Anthropometric parameters are currently used for clinical assessment in many clinical applications. That might be beneficial if we applied anthropometric measurement for thickness prediction of the abdominal wall to the schedule of patients’ gastrostomy care. This study aimed to evaluate the anthropometric parameters of abdominal wall thickness (AWT).

Methods
We conducted a cross-sectional study with anthropometric parameters and CT-measured anterior AWT were assessed and analyzed.

Results
The data are collected from January 2020 to March 2021. Arm circumference and body mass index were strongly correlated with AWT at left upper quadrant area and anterior AWT at middle area. The data was created in an TAWT (Thammasat AWT) chart to represent body parameters to AWT.

Conclusions
Arm circumference is related to AWT. A TAWT chart is designed to help medical personnel evaluate the thickness of the abdominal wall and could guide estimating the gastrostomy tube length.
Arterial oxygen desaturation during moderate hypoxia hinders sensorimotor performance
Authors: Keeler Jason M. , Listman Jennifer B. , Hite M. Jo , Heeger David J. , Tourula Erica , Port Nicholas L. , Schlader Zachary J. 
Published: February 2024

Introduction
Moderate hypoxia may impact cognitive and sensorimotor performance prior to self-recognized impairments. Therefore, rapid and objective assessment tools to identify people at risk of impaired function during moderate hypoxia is needed.

Purpose
Test the hypothesis that reductions in arterial oxygen saturation during moderate normobaric hypoxia (FiO2 = 14%) decreases gamified sensorimotor performance as measured by alterations of motor acuity.

Methods
Following three consecutive days of practice, thirty healthy adults (25 ± 5 y, 10 females) completed three bouts of the tablet-based gamified assessment (Statespace Labs, Inc.) of motor acuity at Baseline and 60 and 90 min after exposure to 13.8 ± 0.2% (hypoxia) and 20.1 ± 0.4% (normoxia) oxygen. The gamified assessment involved moving the tablet to aim and shoot at targets. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Performance metrics included shot time and shot variability. Arterial oxyhemoglobin saturation estimated via forehead pulse oximetry (SpO2). Data were analyzed using linear mixed effects models.

Results
Compared to normoxia (99±1%), SpO2 was lower (p<0.001) at 60 (89±3%) and 90 (90±2%) min of hypoxia. Shot time was unaffected by decreases in SpO2 (0.012, p = 0.19). Nor was shot time affected by the interaction between SpO2 decrease and baseline performance (0.006, p = 0.46). Shot variability was greater (i.e., less precision, worse performance) with decreases in SpO2 (0.023, p = 0.02) and depended on the interaction between SpO2 decrease and baseline performance (0.029, p< 0.01).

Conclusion
Decreases in SpO2 during moderate hypoxic exposure hinders sensorimotor performance via decreased motor acuity, i.e., greater variability (less precision) with no change in speed with differing decreases in SpO2. Thus, personnel who are exposed to moderate hypoxia and have greater decreases in SpO2 exhibit lower motor acuity, i.e., less precise movements even though decision time and movement speed are unaffected.
Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs
Authors: Masters Allison K. , Ward Jessica L. , Guillot Emilie , Domenig Oliver , Yuan Lingnan , Mochel Jonathan P. 
Published: February 2024

Objective
To characterize the dose-exposure-response effect of spironolactone on biomarkers of the classical and alternative arms of the renin-angiotensin-aldosterone system (RAAS) in healthy dogs.

Animals
Ten healthy purpose-bred Beagle dogs.

Procedures
Study dogs were randomly allocated to 2 spironolactone dosing groups (2 mg/kg PO q24hr, 4 mg/kg PO q24hr). The dogs received 7-day courses of spironolactone followed by a 14-day washout period in a crossover (AB/BA) design. Angiotensin peptides and aldosterone were measured in serum using equilibrium analysis, and plasma canrenone and 7-α-thiomethyl spironolactone (TMS) were quantified via liquid chromatography-mass spectrometry/mass spectroscopy (LC-MS/MS). Study results were compared before and after dosing and between groups.

Results
Following spironolactone treatment, dogs had a significant increase in serum aldosterone concentration (P = 0.07), with no statistical differences between dosing groups. Significant increases in angiotensin II (P = 0.09), angiotensin I (P = 0.08), angiotensin 1–5 (P = 0.08), and a surrogate marker for plasma renin activity (P = 0.06) were detected compared to baseline following spironolactone treatment during the second treatment period only. Overall, changes from baseline did not significantly differ between spironolactone dosages. RAAS analytes were weakly correlated (R < 0.4) with spironolactone dosage and plasma canrenone or plasma TMS. There were no adverse clinical or biochemical effects seen at any spironolactone dosage during treatment.

Conclusions
Treatment with spironolactone increased serum aldosterone concentration in healthy dogs and impacted other biomarkers of the classical and alternative arms of the RAAS. There was no difference in effect on the RAAS between 2 and 4 mg/kg/day dosing. Dosage of 4 mg/kg/day was safe and well-tolerated in healthy dogs.
Professional relationships during crisis interventions: A scoping review
Authors: Steimle Larissa , von Peter Sebastian , Frank Fabian 
Published: February 2024

Introduction
A crisis can be described as subjective experience that threatens and overwhelms a person’s ability to handle a specific situation. In dealing with crises some people are looking for support from professionals. The “professional relationship” between people experiencing a crisis and professionals plays an important role in the successful management of a crisis which has been widely researched in many contexts. However, regarding outpatient services (e. g. crisis resolution home treatment teams), yet empirical evidence remains limited.

Objective
We aim to explore descriptions of supportive professional relationships during outpatient crisis interventions in empirical literature. Accordingly, a scoping review was conducted to identify types of evidence, map the key concepts, and point out research gaps.

Methods
MEDLINE, PsycINFO, CINAHL and Social Science Citation Index were searched for studies reporting empirical data on the professional relationship between people experiencing a crisis (18+) and professionals (e. g. social workers, psychiatrists) during a crisis intervention, defined as a short-term, face-to-face, low threshold, time-limited, outpatient, and voluntary intervention to cope with crises. Studies were excluded if they were published before 2007, in languages other than English and German, and if they couldn’t be accessed. Included studies were summarized, compared, and synthesized using qualitative content analyses.

Results
3.741 records were identified, of which 8 met the eligibility criteria. Only one study directly focused on the relationship; the others addressed varied aspects. Two studies explored the perspectives of service users, five focused on those of the professionals and one study examined both. The empirical literature was categorized into three main themes: strategies used to develop a supportive professional relationship, factors influencing the relationship and the nature of these relationships.

Discussion
The results reveal a gap in understanding the nature of supportive professional relationships from the service users’ perspective, as well as how professionals construct these relationships.
Protection of prior SARS-CoV-2 infection, COVID-19 boosters, and hybrid immunity against Omicron severe illness: A population-based cohort study of five million residents in Canada
Authors: Wu Shishi , Li Yanhong , Baral Stefan , Mishra Sharmistha , Koh Maria , Golding Haley , Kwong Jeffrey C. , Wei Xiaolin 
Published: February 2024

Background
Evidence on protection of different patterns of infection- and vaccine-acquired immunity against Omicron-associated severe illness is useful in planning booster vaccination strategies. We examined protection of prior SARS-CoV-2 infection, a third or a fourth COVID-19 vaccine dose, and hybrid immunity against Omicron-associated severe illness.

Methods and findings
This population-based cohort study followed five million individuals with at least one SARS-CoV-2 RT-PCR test before November 21, 2021 until an Omicron-associatedhospitalization or death. We used Cox regression models to estimate risks of Omicron-associated hospitalization and a composite severe outcome (hospitalized and death), among individuals with infection- and/or vaccination-acquired immunity. Individuals who were unvaccinated and had no history of a prior infection severed as the reference group. Both adjusted hazard ratios (HR) and corresponding protection (one minus adjusted HR), with 95% confidence intervals (CIs), were reported. Three doses provided 94% (95%CI 93–95) and 93% (95%CI 91–94) protection against Omicron-associated hospitalization at 2–3 and ≥3 months post-vaccination respectively, similar to the protection conferred by three doses and a prior infection (2–3 months: 99%, 95%CI 97–100; ≥3 months: 97%, 95%CI 92–99) and four doses (1 month: 87%, 95%CI 79–92; 1–2 months: 96%, 95%CI 92–98). In individuals ≥65 years old, protection of four doses increased to 95% (95%CI 91–98) at 1–2 months, significantly higher than that of three doses over the follow-up period. Similar results were observed with the composite severe outcome.

Conclusion
At least three antigenic exposures, achieved by vaccination or infection, confers significant protection against Omicron-associated hospitalization and death in all age groups. Our findings support a third dose for the overall population, regardless of prior infection status, and a fourth dose for the elderly to maintain high level of immunity and substantially reduce risk of severe illness at individual level.
The Complete Works of W. H. Auden: Poems, Volume I: 1927–1939, W. H. Auden (2022)
Authors: Gowar Mick 
Published: February 2024

Review of: The Complete Works of W. H. Auden: Poems, Volume I: 1927–1939, W. H. Auden (2022)
Princeton, NJ: Princeton University Press, 848 pp.,
ISBN 978-0691219295, h/bk, £48.0

The Complete Works of W. H. Auden: Poems, Volume II: 1940–1973, W. H. Auden (2022)
Princeton, NJ: Princeton University Press, 1120 pp.,
ISBN 978-0691219301, h/bk, £48.0
Life’s a Gamble: Penetration, the Invisible Girls and Other Stories, Pauline Murray (2023)
Authors: Alonso Maritxu 
Published: February 2024

Review of: Life’s a Gamble: Penetration, the Invisible Girls and Other Stories, Pauline Murray (2023)
London: Omnibus Press, 192 pp.,
ISBN 978-1-91317-270-1, h/bk, £25
I Want You Around: The Ramones and the Making of Rock ‘N’ Roll High School, Stephen B. Armstrong (2023)
Authors: Makagon Daniel 
Published: February 2024

Review of: I Want You Around: The Ramones and the Making of Rock ’N’ Roll High School, Stephen B. Armstrong (2023)
London: Backbeat Books, 394 pp.,
ISBN 978-1-49306-449-6, p/bk, $22.95