bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear crease as a cytodiagnostic feature of papillary thyroid carcinoma in fine‐needle aspiration biopsies
Authors: Deligeorgi‐Politi Helen 
Published: February 2007

AbstractNuclear crease or grooving was found to be a diagnostic feature of papillary thyroid carcinoma (PTC) in fine‐needle aspiration (FNA) biopsies. The FNA biopsies of 37 cases of PTC, 50 cases of multinodular goiter, and 50 cases of follicular neoplasms (45 follicular adenomas and five follicular carcinomas) were examined. The diagnosis was histologically verified in all the cases. The nuclear crease was found to be present in 34 of 37 cases of PTC and in two of five cases of follicular carcinoma. There was no nuclear crease in any of the other cases examined. Thus, it is concluded that the nuclear crease is a fairly constant and characteristic feature of PTC in FNA biopsies and can be used as a valuable diagnostic criterion. Diagn Cytopathol 1987;3:307‐10.
Cytologic diagnosis and monitoring of Hodgkin's disease in cerebrospinal fluid: A case report
Authors: Shenoy Uma A. , Kushner James P. , Schumann G. Berry 
Published: February 2007

AbstractCentral nervous system (CNS) involvement in Hodgkin's disease is rare, but when the tumor extends into the CNS the route of tumor spread is similar to that seen in non‐Hodgkin's lymphoma. Reed‐Sternberg cells were identified in the cerebrospinal fluid (CSF) of a patient with Hodgkin's disease involving the CNS. Sequential cytologic examination of the CSF proved valuable in evaluating the efficacy of therapy. The ability to identify Reed‐Sternberg cells in the CSF makes CSF cytology a useful adjunct in the management of patients with established or suspected CNS involvement of Hodgkin's disease. Diagn Cytopathol 1987;3:323‐5.
Cytodiagnosis of hibernoma: A case report
Authors: Hashimoto Claire H. , Cobb Camilla J. 
Published: February 2007

AbstractCytologic examination of material obtained by fine‐needle aspiration of a supraclavicular mass revealed features that were consistent with a hibernoma. Subsequent histologic study following resection of the mass confirmed the cytologic impression. The clinical, histologic, and cytologic features of this rare tumor along with the differential diagnosis and pitfalls in the cytologic diagnosis are discussed in this article. Diagn Cyto‐pathol 1987;3:326‐9.
Fine‐catheter aspiration cytology of peritoneal cavity: A new system with potential for oncologic diagnosis
Authors: Stewart Richard J. , Gupta Raj K. 
Published: February 2007

AbstractFine‐catheter aspiration cytology of the peritoneal cavity is a new system for obtaining a sample of peritoneal cells in the absence of fluid or the need for lavage. Its potential use in the diagnosis of peritoneal malignancy is illustrated by two case reports. Diagn Cytopathol 1987;3:339‐41.
The diagnosis of chlamydial infection in a cytology laboratory: Ten months' experience using immunofluorescence with and without previous cytologic prediction
Authors: Lindner Luther E. , Nettum John A. 
Published: February 2007

AbstractA Chlamydiadiagnostic service has been established as part of a cytology laboratory, combining prediction of possible infection by routine cytology with definitive testing by immunofluorescence. The first 10 mo of operation have had good clinician acceptance with 527 specimens submitted and 128 reported as positive (24.3%). Routine cytology was more accurate in predicting chlamydial infection than was clinical evaluation (32.8% of cytologically suspected cases were positive versus 20.2% of clinically suspected cases); however, both failed to identify many infected women. The patient selection for testing must be improved since only about 22% of infected women in our population were tested. Nevertheless, the service identified a large number of patients infected with an important sexually transmitted pathogen. Chlamydial diagnosis has become a major component of the laboratory's workload and has been cost‐effective. Diagn Cytopathol.
Nasal eosinophilia in children: Its use in the nasal allergen provocation test
Authors: Jean René , Lellouch‐Tubiana Arielle , Brunet‐Langot Denise , Scheinmann Pierre , Pfister André 
Published: February 2007

AbstractThis pediatric cytological and clinical study aimed at assessing the value of nasal eosinophilia during nasal provocation tests for identifying an offending allergen. The population studied comprised 50 children aged from 4 to 18 yr; 39 of these had well‐characterized allergic rhinitis, which in 21 cases was combined with asthma, and the remaining 11 had nonatopic chronic rhinitis. Nasal secretions, collected by nose blowing, were stained with May‐Grünwald‐Giemsa or Wright stain. The percentage of nasal eosinophils was obtained by examining the cells in the whole slides. Counts were carried out on secretions collected before challenge, after insufflation of saline solution (for verification), and 40 min after insufflation into each nostril of an allergen (housedust mite extract). The nasal provocation test was considered positive when insufflation of the allergen increased nasal eosinophilia by more than 10%, provided that the prechallenge proportion of eosinophils was less than 50%. No increase in specific bronchial resistance was noted. These results indicate that nasal provocation tests are safe, even in asthmatic children.
Respiratory cytopathology in chlorine gas toxicity: A study in 28 subjects
Authors: Shroff Chandralekha P. , Khade Megha V. , Srinivasan Mahalaxmi 
Published: February 2007

AbstractBronchial brushings to evaluate cytopathologic changes were collected from 28 patients exposed to a toxic atmospheric level (66 parts/million) of chlorine gas. Postexposure smears collected on day 5 showed basal‐cell and goblet‐cell hyperplasia, acute inflammation, and chromatolysis of columnar epithelial cells. Columnar epithelial cell syncytia were observed in 15 (53.57%) smears. Nine (32.14%) smears showed abundant nonpigmented alveolar macrophages. Seven (25%) smears from mucosal erosions showed proliferating fibroblasts and capillary fragments; on day 15 and day 25 repeat smears from these seven cases showed evidence of epithelial regeneration and repair byfibrosis. This latter feature could lead to chronic ventilatory incapacitation in patients exposed to toxic levels of chlorine gas.
The potential value of imprint cytology in cytochemical localization of steroid hormone receptors in ovarian cancer
Authors: Masood Shahla 
Published: February 2007

AbstractSteroid hormone receptors were studied in 45 patients with primary, recurrent, or metastatic ovarian cancer in cryostat‐frozen sections and imprint preparations. The ligands, 17 B‐estradiol‐6‐carboxymethyloxine‐bovine serum albumin fluorescein isothiocyanate (FITC‐BSA estradiol) and hydroxypro‐gesteronehemisuccinate bovine serum albumin tetramethylrho‐damine isothiocyanate (TMRITC‐BSA progesterone) were used in the fluorescent cytochemical method. Results were compared with standard dextran‐coated charcoal (DCC) biochemical assay. An overall significant correlation between biochemical values and cytochemical results was found. However, the imprint results were more sensitive and more specific than the frozen section results. A statistically significant difference (P < 0.05) was observed between touch preparation material and frozen section specimens by the fluorescent method.
Fine‐needle aspiration biopsy of tibial adamantinoma: A case report
Authors: Hales Martha S. , Ferrell Linda D. 
Published: February 2007

AbstractAdamantinoma of long bones is a rare, primary bone tumor of controversial histogenesis, usually arising in the anterior mid‐shaft of the tibia. This slowly growing, radiolucent, expansile tumor eventually causes thinning or destruction of overlying cortical bone. Fine‐needle aspiration biopsy (FNAB) is a rapid, safe, and relatively painless means of obtaining diagnostic material from bone tumors, provided the mass has eroded through or markedly attenuated the overlying cortex. A case is presented of primary adamantinoma of the tibia which was sampled first by FNAB and subsequently by surgical biopsy.
Nuclear grooves: A useful criterion in the cytopathologic diagnosis of papillary thyroid carcinoma
Authors: Shurbaji Muhammad S. , Gupta Prabodh K. , Frost John K. 
Published: February 2007

AbstractA recent report emphasized the usefulness of the grooved nucleus as a diagnostic criterion of papillary thyroid carcinoma (PTC) in histopathologic material. The present study was undertaken to evaluate whether grooved nuclei can serve as an additional diagnostic criterion for PTC in cytologic material obtained by fine‐needle aspiration (FNA). Slides from 124 consecutive thyroid FNAs were reviewed. Specimens included 11 PTCs, one follicular carcinoma, six follicular adenomas, eight follicular neoplasms not otherwise specified, 10 cases of chronic thyroiditis, and 88 colloid nodules/adenomatous goiters. Among the PTC cases, grooved nuclei were found in all 11 (100%), intranuclear inclusions in nine (82%), papillary fragments in seven (64%), and psammoma bodies in two (18%). Nuclear grooves were also observed in two of the 113 non‐PTC cases (1.8%), both of which were colloid nodules, one with extensive Hurthle‐cell change. The grooved nuclei were best identified on Papanicolaou‐stained material. They were inconspicuous and difficult to identify in air‐dried Diff‐Quik‐stained material. It appears that the recognition of grooved nuclei among tumor cells is a valuable diagnostic feature of PTC in cytologic material stained with polychromatic Papani‐colaou stain.
Immunocytochemical presentation of alpha‐fetoprotein‐producing gastric cancer in ascitic fluid: A case study
Authors: Kobayashi Tadao K. , Gotoh Takechika , Kamachi Masahiro , Watanabe Shinsuke , Sawaragi Isamu 
Published: February 2007

AbstractA case of primary gastric cancer without hepatic metastasis showing extremely high alpha‐fetoprotein (AFP) levels is reported. This case illustrates the application of the immunoperoxidase technique to ascitic fluid cytology. Papanicolaoustained smears of the ascites permitted the diagnosis of a metastatic carcinoma. A positive reaction to AFP was demonstrated in the tumor cells in the ascitic fluid cellular samples as well as in the paraffin‐embedded tissue section of the primary gastric carcinoma. Rising AFP levels were also detected in ascitic fluid. AFP fractionation using lectin‐affinity‐crossed‐line immunoelectrophoresis showed the hepatic rather than yolk sac type. Reports of such occurrences are few; no study, to the best of our knowledge, has previously documented cytological and immunocytochemical diagnosis in ascitic fluid. AFP‐producing gastric cancer should be considered in the differential diagnosis.
Renal‐cell carcinoma with intranuclear inclusions metastatic to thyroid: A diagnostic problem in aspiration cytology
Authors: Gritsman Andrey Y. , Popok Steven M. , Ro Jae Y. , Dekmezian Roupen H. , Weber Randal S. 
Published: February 2007

AbstractA case of renal‐cell carcinoma (RCC) exhibiting prominent intranuclear inclusions in a metastasis to the thyroid is presented. RCC had been treated in this patient by right nephrectomy 7 yr earlier and by left partial nephrectomy 5 yr earlier; the patient had also received radiation to the neck 4 yr earlier for carcinoma in situ of the left true vocal cord. Aspiration performed on a rapidly enlarging mass in the left lobe of the thyroid revealed both clusters of tumor cells and single tumor cells with prominent intranuclear inclusions. Definitive distinction between a primary and metastatic neoplasm was difficult on the aspiration specimen. Subsequent thyroidectomy confirmed the diagnosis of metastatic renal‐cell carcinoma with intranuclear inclusions by histologic, immunohistochemical, and ultrastructural analysis. The differential diagnosis by aspiration cytology of thyroid neoplasms that contain intranuclear inclusions is discussed.
Cytologic detection of amyloid in duodenal and ureteral brushings
Authors: Korat Orly , Yachnis Anthony T. , Ernst Carolyn S. 
Published: February 2007

AbstractTwo cases of amyloidosis diagnosed on cytology brush specimens are described. Gastrointestinal involvement in a patient with primary amyloidosis and renal involvement in a patient with multiple myeloma were diagnosed on duodenal and ureteral brush specimens, respectively. Familiarity with the staining characteristics of amyloid should increase it as a consideration in the differential diagnosis of certain specimen types.
Acquired gluteal myospherulosis secondary to intramuscular injections of petrolatum‐based hormones: A case report diagnosed by fine‐needle aspiration cytology
Authors: Vuong Phat N. 
Published: February 2007

AbstractA case of acquired myospherulosis of the right gluteal region diagnosed by FNA cytology is reported in a woman who had received a series of intramuscular injections of petrolatumbased hormones. The lesion is characterized by inflammatory pseudocystic nodules containing saccular formations with erythrocytes or “bags of marbles.” It results from a physical process similar to the emulsion phenomenon between nonresorbent oily material and plasma. This process gives rise to sequestration of blood corpuscles by oily materials and thus development of foreign body granulomas.
Fine‐needle aspiration cytology of histiocytosis X: A case report
Authors: Layfield Lester J. , Bhuta Sunita 
Published: February 2007

AbstractThe cytologic features of a case of histiocytosis X diagnosed by fine‐needle aspiration biopsy of a right cervical lymph node in a 15‐mo‐old girl are reported. Characteristic reticuloendothelial cells with abundant cytoplasm and grooved nuclei were observed. Electron microscopy of the aspiration‐derived specimen revealed Birbeck granules. The cytologic pattern and electron microscopic demonstration of Birbeck granules allowed definite diagnosis of lymph node involvement by histiocytosis X, negating the need for open biopsy. The cytologic differential diagnosis and current diagnostic criteria for histiocytosis X are discussed.
Fine‐needle aspiration cytology of chondromyxoid fibroma: A case report
Authors: Layfield Lester J. , Ferreiro Jorge A. 
Published: February 2007

AbstractThe cytologic presentation of a case of chondromyxoid fibroma studied by fine‐needle aspiration in a 17‐yr‐old black male is described. The cytologic features of chondromyxoid fibroma are presented, and the differential diagnosis of intraosseous cartilaginous neoplasms is reviewed, emphasizing the cytomorphologic differentiation of chondromyxoid fibroma from chondrosarcoma, enchondroma, and chondroblastoma.
Fine‐needle aspiration cytology of an adult rhabdomyoma of the head and neck
Authors: Bertholf Marsha F. , Frierson Henry F. , Feldman Philip S. 
Published: February 2007

AbstractThe cytologic features of a multifocal adult rhabdomyoma of the head and neck, as observed in a fine‐needle aspiration specimen, are described. Cross‐striations and characteristic cytoplasmic “crystals” were conspicuous in the cytologic preparations and also during ultrastructural examination. The cytologic features of adult rhabdomyoma are distinctive, allowing a rapid specific diagnosis.
The fine‐needle aspiration appearance of the follicular variant of thyroid papillary carcinoma: A report of three cases
Authors: Hugh Judith C. , Duggan Máire A. , Chang‐Poon Vivien 
Published: February 2007

AbstractThe follicular variant of thyroid papillary carcinoma (FVTPC) is an uncommon neoplasm with the architectural features of a follicular lesion and the nuclear characteristics of a papillary carcinoma. The fine‐needle aspiration (FNA) appearance is underreported in the literature. Three cases of histologically confirmed FVTPC that were aspirated prior to surgery are presented. Although the cytological features were suspicious or confirmatory of a low‐grade thyroid carcinoma, they did not convey a specific diagnosis of the FVTPC. We suggest that this variant is recognizable as a neoplasm requiring surgical excision on FNA, but that the cytological appearance does not allow its specific diagnosis.
Fine‐needle aspiration cytology of breast: Its impact on surgical practice with an emphasis on the diagnosis of breast abnormalities in young women
Authors: Gupta Raj K. , Naran Sarla , Buchanan Andrew , Fauck Robert , Simpson John 
Published: February 2007

AbstractFine‐needle aspiration cytology (FNAC) of the breast is a minimally invasive yet maximally diagnostic method, often precluding the need of an open biopsy. In young women, in whom breast cancer is a rare disorder, it is also important that carcinoma is recognized without delay so that an appropriate plan of management can be adopted. In this study, we reviewed our experience in a total of 3,226 needle aspirates of breast with particular emphasis on the diagnosis of carcinoma in women under the age of 30. Diagn Cytopathol 1988;4:206–209.
Nephrogenic adenoma of the urinary bladder: A comparison of its cytologic and histopathologic features in ten cases
Authors: Rutgers Joanne L. , Young Robert H. 
Published: February 2007

AbstractWe studied the cytologic features of ten cases of nephrogenic adenoma, a benign proliferative lesion of urothelium that is typically associated with prior trauma or urothelial irritation. The typical cytologic features consisted of numerous vacuolated polygonal cells, including signet‐ring‐like cells, that were isolated or formed papillae or loose groups. Columnar cells and occasional glandular structures were also seen. The cells typically exhibited no or only mild nuclear atypia. There was often a background of acute inflammation. The differential diagnosis of urinary cytologic specimens with these features includes degenerative changes, changes induced by instrumentation, and, most importantly, adenocarcinoma and low‐grade papillary transitional‐cell carcinoma. Diagn Cytopathol 1988;4:210–216.
Epithelial repair versus carcinoma in esophageal brush cytology
Authors: Hoover Lola , Berman Jules J. 
Published: February 2007

AbstractThe distinction between repair atypia and carcinoma in esophageal brushings is often difficult. To establish criteria for making this distinction, the cytologic smears from 121 consecutive esophageal brushings and the companion biopsies were reviewed. The most reliable criteria for malignancy included sharply angulated nuclear rims, a high nuclear/cytoplasmic ratio, and coarsely granular chromatin. Nuclei bearing these features were not numerous and had to be carefully sought. Nuclear pleomorphism was a more consistent feature, but it showed considerable overlap with epithelial repair. Cytologic features of multiple nucleoli, macronucleoli, and loss of polarity were common to both repair and carcinoma. Adherence to the criteria established in this study permits the distinction between repair atypia and carcinoma in almost all cases; however, there are lesions of the esophagus with such overlap between the features of repair and carcinoma that it may not be possible to reach a definitive diagnosis. Specific examples, with illustrations, are discussed as diagnostic guides.
Immunocytochemical staining of different cell types in vaginal smears by monoclonal anti‐DNA methylase antibodies
Authors: Naujoks H. , Siracky J. , Drahovsky D. , Pfeifer G. P. 
Published: February 2007

AbstractEnzymatic methylation of mammalian DNA is closely related to the replication process; also, the synthesis of DNA meth‐ylase, an enzyme that is responsible for this process, is cell cycle related. A monoclonal antibody against DNA methylase recognizes proliferatively active cells in the heterogenous population. We used this antibody to identify the proliferative state of different cell types in normal vaginal smears and in smears of patients with precancerous lesions and cervical cancer. In all preparations, the normal epithelial cells remained unstained. The majority of cancer cells gave a positive immunocytochemical signal indicating the presence of DNA methylase antigen and the proliferative state. Staining was also observed in dyskaryotic cells, particularly in nuclei of parabasal‐type cells. Diagn Cytopathol 1988;4:230–233.
Primary spindle‐cell sarcomas of the breast: Diagnosis by fine‐needle aspiration
Authors: Stanley Michael W. , Tani Edneia M. , Horwitz Charles A. , Tulman Scott , Skoog Lambert 
Published: February 2007

AbstractPrimary breast sarcomas (excluding cystosarcoma phyllodes and its sarcomatous recurrences) are rare neoplasms. Few have been described in the aspiration cytology literature. We report the cytologic features of two cases of stromal sarcoma (both with the pattern of malignant fibrous histiocytoma) and two cases of angiosarcoma. The dominant cytologic features included individual atypical spindle cells and fragments of collagenous stroma. Tumor giant cells were present in one stromal sarcoma. Features of possible significance in the diagnosis of angiosarcoma include obvious vessel formation by atypical spindle cells, bridging of adjacent tumor fragments by spindle cells, and microacinar structures lined by atypical spindle cells. The differential diagnostic considerations in spindle‐cell breast aspirations are discussed.
Fine‐needle aspiration of metastatic atrial myxoma
Authors: Moriarty Ann T. , Nelson William A. , George Kathryn , Waller Bruce F. 
Published: February 2007

AbstractAtrial myxoma is the most common primary neoplasm of the heart, but “metastatic” or embolic phenomena are rare. The first reported case of “metastatic” atrial myxoma diagnosed by fine‐needle aspiration biopsy is presented. It occurred in a 54‐yr‐old woman with multiple metastatic lesions. The cytologic and histologic findings of the fine‐needle aspiration biopsy and subsequent surgical excision are presented as is a discussion of the incidence, origin, and clinical findings of atrial myxoma and the characteristics of its emboli. Diagn Cytopathol 1988;4:250–253.
A history of aspiration biopsy with special attention to prostate biopsy
Authors: Johenning Paul W. 
Published: February 2007

AbstractThe history of needle biopsy is outlined from the early 19th century when the first use of needles for biopsy was recorded. The development of aspiration biopsy, largely at Memorial Hospital in New York in the 1930s, followed by its virtual disappearance in the 1940s and 1950s, and its reemergence in the 1960s, is traced. Special attention is given to the history of aspiration biopsy of the prostate from its origins up to the present day. Diagn Cytopathol 1988;4:265–268.
Fluorescence of blastomyces and other fungi in papanicolaou‐stained pulmonary cytology preparations: Comparison with light microscopy
Authors: Subramony Charu , Cason Zelma , Gong Jody C. , Evers Carl G. 
Published: February 2007

AbstractIn this study, 152 Papanicolaou‐stained pulmonary cytologic smears from 15 known cases of pulmonary fungal infection were randomly mixed with 194 control pulmonary smears. All slides were examined for fungi by three observers, first by light microscopy and then by fluorescent microscopy. The results of the light and fluorescent microscopy were compared. It was concluded that when both methods were used for fungal detection, the yield of positive results was higher.
Aspiration cytology of retinoblastoma: Light and electron microscopic correlations
Authors: Akhtar Mohammed , Ali M. Ashraf , Sabbah Rajeh , Sackey Kwesi , Bakry Mohammed 
Published: February 2007

AbstractA series of 16 cases of retinoblastoma diagnosed by fine‐needle aspiration biopsy (FNAB) and confirmed by histologic examination is reviewed, and the salient cytomorphologic features are described. Two types of cells were encountered in the aspiration smears; type I cells were undifferentiated while type II cells showed more differentiation and frequently revealed cytoplasmic processes that are probably indicative of early photoreceptor differentiation. Flexner‐Wintersteiner rosettes characteristic of retinoblastoma were found in 10 of 16 cases. These findings were further correlated with ultrastructural examination of the tumors in nine cases. It is concluded that the presence of rosettes and type II cells with cytoplasmic processes are the two features that are most helpful in the FNAB diagnosis of retinoblastoma.