bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organocatalytic Synthesis of (2S,3R)‐3‐Hydroxy‐3‐methyl‐proline (OHMePro), a Component of Polyoxypeptins, and Relatives Using OHMePro Itself as a Catalyst.
Authors: Yoshitomi Yayoi , Makino Kazuishi , Hamada Yasumasa 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Arbutin Derivative from the Herb of Myrothamnus flabellifolia Welw.
Authors: Engelhardt C. , Petereit F. , Anke J. , Hensel A. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Bitriazolyl Nucleosides and Unexpectedly Different Reactivity of Azidotriazole Nucleoside Isomers in the Huisgen Reaction.
Authors: Xia Yi , Li Wei , Qu Fanqi , Fan Zhijin , Liu Xiufeng , Berro Charles , Rauzy Evelyne , Peng Ling 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 15‐Demethyl Brefeldin A (Ia) and Its 7‐epi Isomer (Ib).
Authors: Shen Xin , Yang Yong‐Qing , Hu Qi , Huang Jia‐Hui , Gao Jian , Wu Yi‐Kang 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthetic Studies on a Marine Natural Product, Palmerolide A (I): Synthesis of C1—C9 and C15—C21 Fragments.
Authors: Kaliappan Krishna P. , Gowrisankar Parthasarathy 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biaryl Cannabinoid Mimetics — Synthesis and Structure—Activity Relationship.
Authors: Worm Karin , Zhou Q. Jean , Stabley Gabriel J. , DeHaven Robert N. , Dolle Roland E. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Controlled Functional Group Presentations in Dendrimers as a Tool to Probe the Hyperbranched Architecture
Authors: Ambade Ashootosh V. , Chen Yangbin , Thayumanavan S. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dendrimer‐Like Polymers: A New Class of Structurally Precise Dendrimers with Macromolecular Generations
Authors: Taton Daniel , Feng Xiaoshuang , Gnanou Yves 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supramolecular Chemistry for the Self‐Assembly of Fullerene‐Rich Dendrimers
Authors: Hahn Uwe , Cardinali Francois , Nierengarten Jean‐Francois 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organometallic Methods for the Synthesis and Functionalization of Azaindoles
Authors: Song Jinhua J. , Reeves Jonathan T. , Gallou Fabrice , Tan Zhulin , Yee Nathan K. , Senanayake Chris H. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Developments in the Synthesis of Prostaglandins and Analogues
Authors: Das Saibal , Chandrasekhar Srivari , Yadav Jhillu Singh Yadav Jhillu Singh , Gree Rene 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Anellated, Chiral π‐Conjugated Systems: Tetraphenylenes and Helical β‐Oligothiophenes
Authors: Rajca Andrzej , Rajca Suchada , Pink Maren , Miyasaka Makoto 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Highly Enantioselective Oxazaborolidinone Catalysts for the Reactions of Acyclic α,β‐Unsaturated Ketones
Authors: Harada Toshiro , Kusukawa Takahiro 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Advances in Chemoinformatics
Authors: Agrafiotis Dimitris K. , Bandyopadhyay Deepak , Wegner Joerg K. , van Vlijmen Herman 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dendrimers and Magnetic Resonance Imaging
Authors: Langereis Sander , Dirksen Anouk , Hackeng Tilman M. , van Genderen Marcel H. P. , Meijer E. W. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Primary salivary gland‐type lung cancer
Authors: Molina Julian R. , Aubry Marie Christine , Lewis Jean E. , Wampfler Jason A. , Williams Brent A. , Midthun David E. , Yang Ping , Cassivi Stephen D. 
Published: October 2007

AbstractBACKGROUND.Primary salivary‐type lung cancers are rare tumors that include adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC). The clinicopathologic profiles, symptoms on presentation, and long‐term outcomes of patients with ACC and MEC as an overall group have not been defined recently.METHODS.In this study, the authors analyzed clinical outcome data from 62 patients who presented with a diagnosis of primary salivary‐type lung cancer at the Mayo Clinic (Rochester, Minn) from 1972 to 2002.RESULTS.The median age at diagnosis for patients with MEC was 40 years (range, 6–78 years); and, for patients ACC, the median age at diagnosis was 54 years (range, 21–76 years). ACC was observed more frequently among women and girls. The main presenting symptom for both tumors was cough (70%), followed by dyspnea (51.7%), wheezing (38.3%), obstructive pneumonia (30%), hemoptysis (28.3%), and fever (16.7%). Tissues were available for review from all patients. Among the ACC tumors, 29 (74.4%) were cribriform, 7 (17.9%) were tubular, and 3 (7.7%) were the solid type. Most MEC tumors (65%) were intermediate grade (grade 2), and 30% were low grade (grade 1). Most salivary‐type lung cancers presented in the trachea, in the carina, or in a main stem bronchus (70.7%). This location was observed more often (82.5%) for ACC tumors compared with MEC tumors (44.4%). Involvement of the lymph nodes was observed in 20% of patients and was more common among the patients with ACC (30.8%). Distant metastases were observed in 30.4% of the patients (15 patients in the ACC group [40.5%] compared with only 2 patients in the MEC group [10.5%]; P = .03). For patients who underwent complete surgical resection, the 3‐, 5‐, and 10‐year survival rates were 82%, 70%, and 63%, respectively. The survival rates for surgical MEC patients were 94% at 3 years and 87% at both 5 years and 10 years. For surgical ACC patients, the survival rates were 73%, 57%, and 45% at 3, 5, and 10 years, respectively. The survival rate for patients with ACC who did not undergo surgery was 74% at 3 years, 53% at 5 years, and 31% at 10 years. The difference in survival between surgical and nonsurgical patients was statistically significant (P < .01).CONCLUSIONS.Patients with MEC and ACC frequently have a good long‐term prognosis but do not always have indolent diseases. Local recurrence is likely if complete surgical resection is not achieved. ACC has a higher likelihood than MEC to metastasize. Overall, patients with MEC survive better than patients with ACC. Cancer 2007. © 2007 American Cancer Society.
Challenges in the recruitment of adolescents and young adults to cancer clinical trials
Authors: Burke Megan E. , Albritton Karen , Marina Neyssa 
Published: October 2007

AbstractThe adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, yet today AYAs have inferior survival rates to children and some adult cohorts. Survival rates are particularly poor for AYA‐specific diseases such as sarcomas. Research involving children and adults diagnosed with common malignancies such as acute lymphoblastic leukemia has resulted in improved survival rates. However, AYAs have not directly benefited from such research due to low rates of access to and accrual on clinical trials. AYAs are less likely to have insurance or access to healthcare, are more likely to see providers who are not part of research institutions, and are less likely to be referred to or to join clinical trials, all of which may contribute to worse outcomes. Few clinical trials target AYA‐specific diseases, leading to little information regarding how these diseases behave and what role the host plays. Tumor samples for this population are underrepresented in national tumor banks. Coupled with the need for more clinical trials that focus on AYA‐specific cancers, better collaboration between adult and pediatric cooperative groups as well as increased education among community oncologists and primary care providers will be needed to enhance participation in clinical trials with the goal to increase survival and improve quality of that survival. Cancer 2007. © 2007 American Cancer Society.
Functional delay of myelination of auditory delay lines in the nucleus laminaris of the barn owl
Authors: Cheng Shih‐Min , Carr Catherine E. 
Published: October 2007

AbstractIn the barn owl, maps of interaural time difference (ITD) are created in the nucleus laminaris (NL) by interdigitating axons that act as delay lines. Adult delay line axons are myelinated, and this myelination is timely, coinciding with the attainment of adult head size, and stable ITD cues. The proximal portions of the axons become myelinated in late embryonic life, but the delay line portions of the axon in NL remain unmyelinated until the first postnatal week. Myelination of the delay lines peaks at the third week posthatch, and myelinating oligodendrocyte density approaches adult levels by one month, when the head reaches its adult width. Migration of oligodendrocyte progenitors into NL and the subsequent onset of myelination may be restricted by a glial barrier in late embryonic stages and the first posthatch week, since the loss of tenascin‐C immunoreactivity in NL is correlated with oligodendrocyte progenitor migration into NL. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007
Distribution of neurotrophin‐3 during the ontogeny and regeneration of the lizard (Gallotia galloti) visual system
Authors: Santos E. , Monzón‐Mayor M. , Romero‐Alemán M.M. , Yanes C. 
Published: October 2007

AbstractWe have previously described the spontaneous regeneration of retinal ganglion cell axons after optic nerve (ON) transection in the adult Gallotia galloti. As neurotrophin‐3 (NT‐3) is involved in neuronal differentiation, survival and synaptic plasticity, we performed a comparative immunohistochemical study of NT‐3 during the ontogeny and regeneration (after 0.5, 1, 3, 6, 9, and 12 months postlesion) of the lizard visual system to reveal its distribution and changes during these events. For characterization of NT‐3+ cells, we performed double labelings using the neuronal markers HuC‐D, Pax6 and parvalbumin (Parv), the microglial marker tomato lectin or Lycopersicon esculentum agglutinin (LEA), and the astroglial markers vimentin (Vim) and glial fibrillary acidic protein (GFAP). Subpopulations of retinal and tectal neurons were NT‐3+ from early embryonic stages to adulthood. Nerve fibers within the retinal nerve fiber layer, both plexiform layers and the retinorecipient layers in the optic tectum (OT) were also stained. In addition, NT‐3+/GFAP+ and NT‐3+/Vim+ astrocytes were detected in the ON, chiasm and optic tract in postnatal and adult lizards. At 1 month postlesion, abundant NT‐3+/GFAP+ astrocytes and NT‐3−/LEA+ microglia/macrophages were stained in the lesioned ON, whereas NT‐3 became downregulated in the experimental retina and OT. Interestingly, at 9 and 12 months postlesion, the staining in the experimental retina resembled that in control animals, whereas bundles of putative regrown fibers showed a disorganized staining pattern in the OT. Altogether, we demonstrate that NT‐3 is widely distributed in the lizard visual system and its changes after ON transection might be permissive for the successful axonal regrowth. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2008
TLR‐mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
Authors: Barr Tom A. , Brown Sheila , Ryan Gemma , Zhao Jiexin , Gray David 
Published: October 2007

AbstractIn addition to their role in humoral immunity, B lymphocytes are important antigen‐presenting cells (APC). In the same way as other APC, B cells make cytokines upon activation and have the potential to modulate T cell responses. In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll‐like receptors (TLR) in the control of secretion of IL‐6, IL‐10, IL‐12 and IFN‐γ by B cells. Production of some cytokines was restricted to particular subsets. Marginal zone and B1 cells were the predominant source of B cell IL‐10 in the spleen. Conversely, follicular B cells were found to express IFN‐γ mRNA directly ex vivo. The nature of the activating stimulus dramatically influenced the cytokine made by B cells. Thus, in response to combined TLR stimulation, or via phorbol esters, IFN‐γ was secreted. IL‐10 was elicited by T‐dependent activation or stimulation through TLR2, 4 or 9. This pattern of cytokine expression contrasts with that elicited from dendritic cells. QRT‐PCR array data indicate that this may be due to differential expression of TLR signalling molecules, effectors and adaptors. Our data highlight the potentially unique nature of immune modulation when B cells act as APC.
Both CD133+ and CD133– medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK‐mediated cytotoxicity
Authors: Castriconi Roberta , Dondero Alessandra , Negri Francesca , Bellora Francesca , Nozza Paolo , Carnemolla Barbara , Raso Alessandro , Moretta Lorenzo , Moretta Alessandro , Bottino Cristina 
Published: October 2007

AbstractAdoptive cellular immunotherapy has been proposed as an additional treatment of medulloblastoma, an intracranial tumor characterized by a particularly poor prognosis. However, little is known on the ability of the immune system to effectively attack this tumor. In this study, we show that activated human NK cells efficiently kill medulloblastoma cell lines in vitro. NK‐mediated killing involved different activating receptors (including NKp46, NKp30, DNAM‐1 and NKG2D) and correlated with the presence of their specific ligands on tumor cells. In contrast, the absence of major adhesion interactions, such as LFA‐1/ICAM did not impair the NK‐mediated cytotoxicity. Medulloblastoma expressed a number of tumor‐associated molecules including CD146 and CD133, considered a marker for cancer stem cells. Remarkably, both CD133‐positive and CD133‐negative cell lines were susceptible to lysis. Tumor cells also expressed molecules that are currently used as diagnostic tools for neuroblastoma cell identification. In particular, B7 homolog 3 (B7‐H3) was expressed by all the medulloblastoma cell lines analyzed, while the presence of GD2 and NB84 was restricted to given cell lines and/or marked a defined tumor cell subset.
IL‐21 regulates experimental colitis by modulating the balance between Treg and Th17 cells
Authors: Fantini Massimo C. , Rizzo Agelamaria , Fina Daniele , Caruso Roberta , Becker Christoph , Neurath Markus F. , MacDonald Thomas T. , Pallone Francesco , Monteleone Giovanni 
Published: October 2007

AbstractRegulatory T (Treg) cells play a key role in the maintenance of the immune system homeostasis. Treg cells can be generated in the periphery under control of TGF‐β, a cytokine involved in the negative control of the immune system. However, TGF‐β cooperates with IL‐6 in the generation of Th17 cells, a novel class of effector cells involved in numerous inflammatory diseases, including colitis. Therefore, TGF‐β emerges as a mediator of both anti‐inflammatory and pro‐inflammatory processes, depending on the local cytokine milieu. Here we demonstrate that IL‐21, a type‐1 cytokine produced by T cells and involved in the pathogenesis of immune‐mediated diseases, prevents the TGF‐β‐dependent expression of FoxP3, the master regulator of Treg cell commitment, and the induction of suppressive capacity in naive CD4+ T cells, while promoting the differentiation of Th17 cells. In vivo, CD4+ naive T cells activated in the presence of TGF‐β and IL‐21 failed to suppress colitis while inducing an inflammatory response characterized by high levels of IL‐17 and RORγt, the transcription factor expressed by Th17 cells. Therefore, IL‐21 emerges as a key modulator of TGF‐β signaling, leading to the reciprocal differentiation of Treg and Th17 cells.
In Situ Amperometric Characterization of Liposome Suspensions with Concomitant Oxygen Reduction
Authors: DeNardis Nadica Ivošević , Žutić Vera , Svetličić Vesna , Frkanec Ruža , Tomašić Jelka 
Published: October 2007

AbstractAmperometry of oxygen reduction at the dropping mercury electrode (DME) was applied for in situ characterization of liposome suspensions in terms of concentration, level of polydispersity and potential range of adhesion. Liposomes prepared from egg‐phosphatidylchloline/cholesterol/dicetylphosphate in the molar ratio of 7 : 5 : 1 were suspended in phosphate‐buffered saline (PBS). Adhesion signals of single liposomes in air‐saturated suspensions were detected in the broad potential range (from −100 to −1200 mV vs. 0.1 M Ag/AgCl reference electrode) as transient enhacements of oxygen reduction. Measured concentration range in air‐saturated suspensions was 106–108 liposomes/L.
Preparation and Characterization of Mixed‐Valent Nickel Oxide/Nickel Hexacyanoferrate Hybrid Films and Their Electrocatalytic Properties
Authors: Chen Shen‐Ming , Liou Ching‐Yeoung , Thangamuthu R. 
Published: October 2007

AbstractPolynuclear mixed‐valent nickel oxide and nickel hexacyanoferrate hybrid film was prepared on glassy carbon electrode by multiple scan cyclic voltammetry. The film growth was monitored using electrochemical quartz crystal microbalance (EQCM). The cyclic voltammogram of the nickel hexacyanoferrate film is characterized by single redox couple whereas nickel oxide/nickel hexacyanoferrate hybrid film exhibits two redox couples. Cyclic voltammetric features suggest that the charge transfer process in both films resembles that of surface‐confined redox species. In stronger basic solution (pH ≥9), nickel hexacyanoferrate film was gradually converted into nickel oxide film during potentiodynamic cycling. The peak potential of nickel oxide redox couple moved into more negative side with increasing pH of contacting solution whereas the peak potential of nickel hexacyanoferrate redox couple remains the same. Electrocatalytic behavior of hybrid film coated electrodes toward ascorbic acid, hydrazine and hydroxylamine was investigated using cyclic voltammetry technique. Analytical application of nickel oxide/nickel hexacyanoferrate hybrid film electrode was tested in amperometry and flow injection analysis.
Electrochemical DNA Biosensors Based on Palladium Nanoparticles Combined with Carbon Nanotubes
Authors: Chang Zhu , Fan Hao , Zhao Kun , Chen Miao , He Pingang , Fang Yuzhi 
Published: October 2007

AbstractPalladium nanoparticles, in combination with multi‐walled carbon nanotubes (MWCNTs), were used to fabricate a sensitivity‐enhanced electrochemical DNA biosensor. MWCNTs and palladium nanoparticles were dispersed in Nafion, which were used to modify a glassy carbon electrode (GCE). Oligonucleotides with amino groups at the 5′ end were covalently linked onto carboxylic groups of MWCNTs on the electrode. The hybridization events were monitored by differential pulse voltammetry (DPV) measurement using methylene blue (MB) as an indicator. Due to the ability of carbon nanotubes to promote electron‐transfer and the high catalytic activities of palladium nanoparticles for electrochemical reaction of MB, the sensitivity of presented electrochemical DNA biosensors was remarkably improved. The detection limit of the method for target DNA was 1.2×10−13 M.
Voltammetric Analysis of Trace Levels of Platinum Group Metals – Principles and Applications
Authors: Locatelli Clinio 
Published: October 2007

AbstractThe compelling use of autocatalytic converters, containing platinum group metals (PGMs), has been the cause, in the environmental and biological matrices, of an increasing concentration of such metals. For this reason, in the last decade, the literature has reported several papers regarding analytical procedures for the determination of Pt(II), Pd(II) and Rh(III) in real samples, generally employing spectroscopic methods. The present review intends to highlight the contribution of the voltammetric techniques for the determination of these metals, including also those less investigated, i.e. Iridium, Osmium and Ruthenium.
Molecular identification of COL6A3‐CSF1 fusion transcripts in tenosynovial giant cell tumors
Authors: Möller Emely , Mandahl Nils , Mertens Fredrik , Panagopoulos Ioannis 
Published: October 2007

AbstractTenosynovial giant cell tumors (TGCTs) are benign lesions of the tendon sheaths that primarily affect the fingers, ankles, or feet. Cytogenetic data have shown that 1p13 is most frequently involved in structural aberrations and that 2q37 is its most common translocation partner. The genes involved in the translocation t(1;2)(p13;q37) were recently identified: the colony‐stimulating factor‐1 (CSF1 or M‐CSF1) at 1p13 and the collagen type VI alpha‐3 (COL6A3) at 2q37. Based upon the suggestion that a fusion of these genes through the translocation would result in overexpression of CSF1 due to a strong COL6A3 promoter, we performed RT‐PCR on six TGCT cases with t(1;2) to search for a putative COL6A3‐CSF1 fusion gene. Such fusion transcripts were detected in three cases of which one was an in‐frame fusion. In all cases, however, the breakpoints in CSF1 appeared downstream of exon 5, indicating that the amino‐terminal part of CSF1, which interacts with its receptor CSF1R, is not encoded by the the chimeric transcripts we identified. The pathogenetic mechanism of these chimeric transcripts is therefore unclear. © 2007 Wiley‐Liss, Inc.