bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of CT-based navigation, large femoral head, and dual-mobility liner on achieving the required range of motion in total hip arthroplasty
Authors: Konishi Toshiki , Hamai Satoshi , Kawahara Shinya , Hara Daisuke , Sato Taishi , Motomura Goro , Utsunomiya Takeshi , Nakashima Yasuharu 
Published: February 2025

AimsThis study aimed to investigate whether the use of CT-based navigation enhances: 1) the accuracy of cup placement; and 2) the achievement rate of required range of motion (ROM). Additionally, we investigated the impact of using a large femoral head and dual-mobility liner on the achievement rates.MethodsThis retrospective study analyzed 60 manual and 51 CT-based navigated primary total hip arthroplasties performed at a single facility. Postoperative CT scans and CT-based simulation software were employed to measure the cup orientation and to simulate the ROM. We compared the absolute errors for radiological inclination (RI) and radiological anteversion (RA) between the two groups. We also examined whether the simulated ROM met the required ROM criteria, defined as flexion > 110°, internal rotation > 30°, extension > 30°, and external rotation > 30°. Furthermore, we performed simulations with 36 mm femoral head and dual-mobility liner.ResultsThe absolute errors of RI and RA from the preoperative plan were significantly smaller in the CT-based navigation group (3.7° (SD 3.5°) vs 5.1° (SD 3.5°); p = 0.022, and 3.9° (SD 3.5°) vs 6.8° (SD 5.0°); p = 0.001, respectively). The proportion of cases achieving the required ROM in all directions was significantly higher in the CT-based navigation group (42% vs 63%; p = 0.036). The achievement rates of the required ROM were significantly higher with the use of a 36 mm ball or dual-mobility liner compared to the use of a 32 mm ball (65% vs 51%; p = 0.040 and 77% vs 51%; p ≤ 0.001, respectively).ConclusionCT-based navigation enhanced required ROM achievement rates by > 20%, regardless of the ball diameter. The improved accuracy of cup placement through CT-based navigation likely contributed to the enhancement. Furthermore, the use of large femoral heads and dual-mobility liners also improved the required ROM achievement rates. In cases with a high risk of dislocation, use of these devices is preferred.Cite this article: Bone Jt Open 2025;6(2):155–163.
Preparation and characterization of chitosan derived from slipper lobster (Thenus orientalis)
Authors: KARNILA RAHMAN , HASAN BUSTARI , IRIANI DIAN , PUTRA HARIFA SYAH , FAUZI MUHAMMAD , ZULFARINA ZULFARINA 
Published: February 2025

Abstract. Karnila R, Hasan B, Iriani D, Putra HS, Fauzi M, Zulfarina. 2024. Preparation and characterization of chitosan derived from slipper lobster (Thenus orientalis). Biodiversitas 25: 4360-4369. Slipper lobster (Thenus orientalis (Lund, 1793)) is a marine fishery commodity that can be utilized its large carapace (proportion >50%) to be converted into chitosan, but ideal, accurate and rapid characterization has not been developed in detecting chitosan and its derivatives as potential raw materials for nutraceuticals. In this study, the proportion and chemical composition of fan shrimp were analyzed, and the carapace of fan shrimp was determined for the degree of deacetylation of chitin and chitosan, then chitosan was evaluated for glycosidic chains using LCMS-MS from ESI sources. The method used was descriptive with 3 repetitions. The results showed that the largest proportion of the fan shrimp body was found in the carapace at 52.98%. The highest mineral content in the carapace is calcium at 752 mg/L and the lowest is phosphorus at 0.36 mg/L and higher than meat. The yield value of chitosan was 31.19% with a deacetylation degree of 80.15%. The glycosidic chain of chitosan has many amine groups from the structure of the compound 2-Amino-2-Deoxy-D-Glucose Chitosamine and 2-(Aminomethyl)-N-(3-isopropyl octahydro [1,2,4] triazolo [4,3-a] pyridine-6-il)-1 piperidinekar kotakamida which have high quality chitosan affinity, but there is a compound 5-Aminomethyl-2,4-Dihydro [1,2,4] Triazol-3-One Hydrochloride and N-[3-Methyl-2-(4-methyl-1-piperazinyl)-butyl] isoleucinamide hydrochloride which tends to be dissociated and cationized by HCl. Overall, these data suggest the glycosidic chain of slipper lobster has potential as a raw material for nutraceuticals and functional food ingredients.
Phenotypic and genotypic screening of Bacillus cereus local isolates for their antimicrobial resistance
Authors: FARHANI IZZADINI , DEWANTI-HARIYADI RATIH , LIOE HANIFAH NURYANI 
Published: February 2025

Abstract. Farhani I, Dewanti-Hariyadi R, Lioe HN. 2024. Phenotypic and genotypic screening of Bacillus cereus local isolates for their antimicrobial resistance. Biodiversitas 25: 4507-4514. Bacillus cereus is a sporeformer bacterium that ranks second as Indonesia's most common cause of foodborne illnesses from 2000 to 2015. The bacterium produces cereulides and enterotoxins, which trigger emetic and diarrheal syndromes. The rise of antibiotic resistance in pathogens such as B. cereus could complicate treatment and allow the bacterium to act as the reservoir of antibiotic-resistant genes. Currently, antibiotic resistance in B. cereus has not been reported in Indonesia. This study aims to evaluate the antibiotic resistance of 21 B. cereus local isolates obtained from foods against eight different antibiotics. The phenotypic resistance was evaluated using the Kirby-Bauer disc diffusion method, while resistance genes were detected using a polymerase chain reaction targeting the bla1, tetL, and tetB genes. None of the isolates (0%; 0/21) showed resistance to chloramphenicol, ciprofloxacin, or erythromycin. However, all (100%; 21/21) were resistant to ampicillin, cefoxitin, cephalothin, and penicillin G. Additionally, 4.8% (1/21) were susceptible to erythromycin, while 33.3% (7/21) were resistant to tetracycline. The detection of resistance-encoding genes revealed that 100% (21/21) of the isolates possessed the bla1 gene, but tetL and tetB genes were absent in any of the isolates (0%; 0/21).
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human serum and plasma
Authors: Ott Myriam , Singh Neeraj , Bauland Friederike , Köppl Daniel , Kandler Kerstin , Gaudl Alexander , Geistanger Andrea , Ceglarek Uta , Rauh Manfred , Geletneky Christian , Taibon Judith 
Published: February 2025

Abstract

Objectives
Accurate measurement of serum cortisol is crucial for the diagnosis and management of adrenal disorders. Thus, we have developed a novel isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC MS/MS)-based candidate reference measurement procedure (RMP) to quantify cortisol in human serum/plasma, offering higher sensitivity and reliability compared to existing RMPs.

Methods
Quantitative Nuclear Magnetic Resonance spectroscopic (qNMR) methodology has been utilized to assign the absolute content (g/g) and SI-traceability to the reference materials. A novel two-dimensional heart-cut liquid chromatography (LC) approach was implemented for the LC-MS/MS, combined with a supported liquid extraction (SLE) sample preparation protocol. A multi-day validation experiment assessed precision and accuracy. Reproducibility was assessed by comparing procedure results between two independent laboratories, and measurement uncertainty (MU) was evaluated in compliance with current guidelines.

Results
The established RMP exhibited high sensitivity, with a quantification range of 0.800–600 ng/mL (2.21–1,655 nmol/L), exceeding the ranges of existing JCTLM-listed RMPs. Intermediate precision was ≤2.6 %, and repeatability ranged from 0.9 to 1.9 % across all concentration levels. The relative mean bias ranged from −1.3 to 1.4 % for all matrices and concentration levels. Measurement uncertainties (MU) for cortisol in single measurements were ≤2.8 % regardless of the concentration level and sample type. Using the certified International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference panel, the equivalence between the candidate RMP and the Joint Committee on Traceability in Laboratory Medicine (JCTLM) listed RMPs (NRMeth 57 and NRMeth 8) was assessed, revealing excellent agreement.

Conclusions
This RMP allows for highly sensitive and reproducible determination of cortisol. The performance of the RMP facilitates the standardization of routine assays and ensures traceability in the measurement of individual patient samples.
Propagation of waves from finite sources arranged in line segments within an infinite triangular lattice
Authors: Kapanadze David , Vashakidze Zurab 
Published: February 2025

Abstract
This paper examines the propagation of time-harmonic waves in a two-dimensional triangular lattice with a lattice constant

a
=
1

{a=1}

. The sources are positioned along line segments within the lattice. Specifically, we investigate the discrete Helmholtz equation with a wavenumber

k
∈

(
0
,

2
⁢

2

)

{k\in(0,2\sqrt{2})}

, where input data is prescribed on finite rows or columns of lattice sites. We focus on two main questions: the efficacy of the numerical methods employed in evaluating the Green’s function, and the necessity of the cone condition. Consistent with a continuum theory, we employ the notion of radiating solution and establish a unique solvability result and Green’s representation formula using difference potentials. Finally, we propose a numerical computation method and demonstrate its efficiency through examples related to the propagation problems in the left-handed two-dimensional inductor-capacitor metamaterial.
Why less is sometimes more
Authors: Berger Bernhard J. , Plump Christina , Drechsler Rolf 
Published: February 2025

Abstract
Explaining and understanding AI-generated policies of control problems is crucial for the acceptance of such policies. Based on an optimisation challenge that took place at GECCO 2024, we describe different solutions for optimising generated policies for the well-known game 2048. At the same time, these generated policies aim to be simpler to understand and, thus, their decisions explainable in contrast to current solutions for 2048, as, e.g., neural network-based models. Our approach uses only Boolean expressions in the policy, and the optimisation shows that such a policy has advantages compared to more complex policy variants. The optimisation generates better results in a shorter time than for non-Boolean expressions. Additionally, the Boolean policies are smaller in size and can be reduced even more when applying existing techniques for term rewriting and simplification. These simplifications, again, may aid in understanding the policy’s decision.
Corrosion behavior of a dissimilar Inconel 625 superalloy and AISI 316L stainless steel weld
Authors: Dokme Fatih , Kulekci Mustafa Kemal , Engin Kaan Emre , Esme Ugur 
Published: February 2025

Abstract
Corrosion significantly impacts the welding of dissimilar components, leading to a decrease in the lifespan of products. The primary aim of this research is to examine the corrosion behavior of the weld region in dissimilar welding of Inconel 625 and AISI 316L plates with a thickness of 20 mm. The plates are weld together by using continuous current gas tungsten arc welding (CCGTA) and pulsed current gas tungsten arc welding (PCGTAW) methods. The process employs ERNiCr-3, TIG 316L, and a twisted combination of both filler metals (ERNiCr-3+TIG 316L). Specimens with dimensions of 12 mm × 20 mm × 42 mm are obtained by cutting the weld samples for corrosion tests. The divided parts are each submerged in a 100 ml pool of sulfuric acid and are maintained for a combined duration of 240 h. A weight loss investigation is undertaken, in addition to metallurgical characterizations of the specimens. Energy Dispersive Spectroscopy (EDS) in conjunction with Scanning Electron Microscopy (SEM) are utilized to conduct metallurgical investigations. It is observed that twisted filler metal and CCGTA welding method results in the highest amount of mass loss. The least corroded sample is obtained by using twisted filler metal combined with PCGTA welding method.
Realizing electronically reconfigurable intrinsic chirality: from no absorption to maximal absorption of any desirable spin
Authors: Khan Muhammad Ismail , Khan Tayyab Ali , Abdelbaky Moustafa , Wong Alex M. H. 
Published: February 2025

Abstract
Circular dichroism – the spin-selective absorption of light – finds diverse applications in medicine, antennas and microwave devices. In this work, we propose and experimentally demonstrate an ultrathin electronically reconfigurable chiral metasurface which exploits the intrinsic symmetries of the meta-molecule to realize any spin absorption based on the handedness of the chirality chosen. We construct the left-chiral and right-chiral states by reconfiguring the meta-molecule into two enantiomeric states, which achieve strong circular dichroism exceeding 82 % at the design frequency of 9.5 GHz. The meta-molecule can be switched into a third (non-chiral) state which is isotropic and transparent. The achieved circular dichroism characteristics remain insensitive to incidence angles up to ±45°. The proposed reconfigurable chiral metasurface achieves left- and right- circular dichroism at the same frequency and with high efficiency, and is an attractive candidate for wide-ranging practical applications in imaging, wireless communication and medicine.
HIV-1 infection facilitates Alzheimer’s disease pathology in humanized APP knock-in immunodeficient mice
Authors: Bhattarai Shaurav , Kadry Rana , Yeapuri Pravin , Lu Yaman , Foster Emma G. , Zhang Chen , Dash Prasanta , Poluektova Larisa Y. , Gorantla Santhi , Mosley R. Lee , Gendelman Howard E. 
Published: February 2025

Abstract

Objectives
Amyloid-β (Aβ) plaque deposition in the brain is a principal pathological feature of both Alzheimer’s disease (AD) and progressive human immunodeficiency virus type one (HIV-1) infection. Both enable Aβ assembly and Aβ protein aggregation. The potential link between HIV-1 and AD remains uncertain, supporting the need for a reliable animal model. HIV-1 is tropic and pathogenic for humans. It does not replicate in mice. The restricted species tropism has slowed progress in basic research activities. The current study seeks to correct animal model limitations.

Methods
We created an AD mouse to address the need to develop an small animal model that allows studies of viral infection by making a knock-in (KI) with the human amyloid precursor protein (APP)KM670,671NL Swedish mutation to the mouse genome. The resulting founder mice were crossed with immunodeficient NOG (NOD. Cg-Prkdc

scid

Il2rg

tm1Sug
Tg(CMV-IL-34)1/Jic) to generate NOG/APPKM670,671NL/IL-34 (NAIL) mice. The mice were reconstituted with human hematopoietic stem cells to generate NAIL mice with functional adaptive and innate human immune systems. Four-month-old, humanized NAIL mice were infected with HIV-1ADA, a macrophage-tropic viral strain then evaluated for viral infection and AD pathology.

Results
Productive HIV-1 infection was confirmed by plasma HIV-1 RNA levels in infected NAIL mice. The viral load increased by tenfold between day 10 and day 25 post-infection. By day 25, viral DNA confirmed the establishment of HIV-1 reservoirs in CD45+ cells from the immune tissues of infected NAIL mice. Additionally, p24 measurements in lymphoid and brain tissues of NAIL mice validated productive HIV-1 infection. Amyloid burden from infected NAIL mice was increased. Immunofluorescence staining revealed co-localization of Aβ fibrils and HLA-DR+ microglia in infected NAIL mice.

Conclusions
These results highlight the AD-HIV model’s unique pathobiological and infectious features where the viral and immune responses can now be measured.
Paul’s Style and the Problem of the Pastoral Letters: Assessing Statistical Models of Description and Inference
Authors: Pracht Erich Benjamin , McCauley Thomas 
Published: February 2025

Abstract
In this study, we combine the core competencies of a New Testament scholar and a mathematician to conduct a stylometric analysis of the Pauline and Pastoral Letters based on 18 epistolary modes of discourse, which we argue are at least as stylistically relevant as traditional features such as term frequencies. By focusing on features of this type, we apply discrete probability models – namely, the binomial, Poisson, and negative binomial distributions – to determine which ones are the best fit for each feature. With our approach, we have found a way to utilize Paul’s authentic letters as a standard of measurement by which the style(s) of the Pastorals can be compared, an essential first step to statistical inference that is generally lacking in Pauline stylometry. With few exceptions, we find that the Pastoral Letters do not contain stylistic differences with the authentic Paulines at a statistically significant level, a finding that disputes many previous studies (especially in the qualitative tradition) that assume stylistic difference, but which is in line with an emerging trend in computational analyses of the Pauline and Pastoral Letters.
Dynamics of closed-form invariant solutions and formal Lagrangian approach to a nonlinear model generated by the Jaulent–Miodek hierarchy
Authors: Usman Muhammad , Hussain Akhtar , Zidan Ahmed M. 
Published: February 2025

Abstract
This study focuses on a (3 + 1)-dimensional nonlinear evolution model derived from the Jaulent–Miodek hierarchy. Our research employed analytical tools to scrutinize the invariance characteristics of this model. However, our primary emphasis is on utilizing the potent Lie group method, which effectively reveals the inherent symmetries within the model and explores solutions that remain invariant under group transformations using symmetry algebra. Furthermore, we investigated the application of Ibragimov’s approach to examine the conservation laws relevant to the model under consideration. This theorem is employed to identify and analyze the conservation laws associated with the (3 + 1)-dimensional nonlinear evolution model, which is essential for understanding the behavior of the system. Our research is significant as it contributes to exploring this particular model and addresses a specific gap in the group theoretic approach within this context.
Evergreen Automation Systems
Authors: Mücksch Christian , Neustadt Andreas 
Published: February 2025

Die Konzeption des „Evergreen Automatisierungssystems“ zielt darauf ab, in der Prozessautomatisierung Innovation und effektives Lebenszyklusmanagement zu integrieren. Die Einführung und Beherrschung solcher Systeme sind mit einer Reihe von Herausforderungen verbunden, die dieser Beitrag detailliert aufzeigt. Die Vision besteht in der Schaffung nachhaltiger und widerstandsfähiger Automatisierungssysteme, die Effizienzsteigerungen ermöglichen und gleichzeitig den komplexen Anforderungen moderner Automatisierungsumgebungen entsprechen.
AAS Submodel Generator
Authors: Heitkamp Dennis , Benndorf Gesa 
Published: February 2025

Industry 4.0 concepts use the Asset Administration Shell (AAS) to represent physical and non-physical assets, facilitating interoperability along the whole product lifecycle. Today, the AAS is barely established in brownfield plants, mainly due to the required manual effort and expert knowledge for setup. This study proposes automated AAS submodel generation, using Large Language Models (LLMs) in order to map data from diverse sources into AAS structures. Experimental results show high accuracy and efficiency. Future work will improve image preprocessing and expand template support.
Utility of artificial intelligence in dermatology: Challenges and perspectives
Authors: Sachdev Sanpreet Singh , Tafti Farheen , Thorat Rohit , Kshirsagar Minal , Pinge Sujata , Savant Suyog 
Published: February 2025

Medicine is entering a transformative era with disruptive technologies such as virtual reality, genomic prediction, data analytics, personalized medicine, stem cell therapy, 3-D printing, and nanorobotics. Dermatology is significantly impacted by these advancements, particularly through artificial intelligence (AI). AI, defined as devices performing functions typically requiring human intelligence, plays an increasingly prominent role in healthcare. John McCarthy coined the term AI in 1956. In dermatology, AI aids in diagnosis, treatment planning, and understanding diseases across communities. Machine learning and deep learning, subsets of AI, require extensive datasets and robust analysis to improve accuracy and performance. AI's integration into dermatology is revolutionizing the field by enabling precision, reducing errors, and minimizing staffing needs. AI tools support dermatologists in diagnosing and treating various conditions, from psoriasis and acne to dermatitis and ulcers. Convolutional neural networks (CNNs) enhance the classification of skin lesions, while predictive models optimize treatment strategies based on patient data. AI's role extends to oncology, where it improves skin cancer detection through image analysis and histopathological assessment. Despite its potential, AI in dermatology faces challenges such as data quality, representativeness, algorithm transparency, and ethical considerations. Addressing biases, standardizing imaging protocols, and enhancing human-machine collaboration are crucial for maximizing AI's benefits.AI holds immense promise in dermatology, offering innovative solutions to enhance patient care and diagnostic accuracy. The future of AI in dermatology includes advancements in vision-language models, federated learning, and precision medicine approaches. Overcoming challenges related to data privacy, regulatory standards, and model evaluation is essential for successful integration into clinical practice. Collaborative efforts among stakeholders are vital to drive progress and realize the full potential of AI, ultimately improving patient outcomes globally.
Vitiligo patients experiencing sensorineural hearing loss: A single-center experience in a tertiary care centre
Authors: Shukla Stuti , Saxena Rohit , Suhag Arushi , Rizvi Sama 
Published: February 2025

Vitiligo is an autoimmune disease distinguished by the gradual and progressive loss of melanocytes, resulting in loss of pigmentation of macules and patches over the skin. The disease's pathophysiology is complex, involving genetic predispositions, environmental triggers, and immune-mediated inflammation, which collectively result in the destruction of myelocytes by autoreactive CD8+ T cells. During the course of the disease, the occurrence of a sensorineural hearing loss (SNHL) is associated with a wide range of factors, including age, age of onset, gender, type and site of vitiligo, and disease duration.To study sensorineural hearing loss in vitiligo patients. This study was conducted in a tertiary care center over a period of one year. A total of 100 patients were included in the study after obtaining informed and written consent from each participant. The results of the audiometry tests were used to classify the patients into different categories of hearing loss based on the WHO classification system. The majority of cases with SNHL are observed in the 41-60 years age group, accounting for 66.7% of the total hearing loss cases. The younger age groups (1-20 years and 21-40 years) show significantly lower rates, 11.1% and 22.2% independently. More than 40 years of age at onset is linked with the development of disease, with male gender comprising 88.9% of the total cases, whereas in the females the numbers are as low as 11.1%. The remarkable risk factors include younger male age group, later onset of the disease, involvement of the head and neck region with prolonged duration of the disease. Preliminary screening and early detection of hearing loss in patients with vitiligo, its monitoring and active interventional planning is recommended for patients having the risk factors to expect the correct treatment and absolute reversal. All cases of vitiligo must be vigilantly screened for hearing loss for accurate and timely prevention as well as treatment.