bluuebunny/crossref_metadata_2025_split huggingface dataset:
An extra X chromosome among adult women in the Million Veteran Program: A more benign perspective of trisomy X
Authors: Davis Shanlee M. , Teerlink Craig C. , Lynch Julie A. , Klamut Natalia , Gorman Bryan R. , Pagadala Meghana S. , Panizzon Matthew S. , Merritt Victoria C. , Genovese Giulio , Ross Judith L. , Hauger Richard L. 
Published: March 2024

AbstractDespite affecting in 1 in every 1000 females, remarkably little is known about trisomy X syndrome (47,XXX), especially among older adults who are undiagnosed. In this study, we aimed to determine the prevalence of 47,XXX among females enrolled in the Million Veterans Program (MVP; mean age 50.2 ± 13.6 years), and compare broad health outcomes between females with 47,XXX and 46,XX matched controls. We identified 61 females with an additional X chromosome, corresponding to a prevalence of 103 per 100,000 females; 27.9% had been clinically diagnosed. Females with 47,XXX had taller stature (+6.1 cm, p < 0.001), greater rate of outpatient encounters (p = 0.026), higher odds of kidney disease (odds ratio [OR] = 12.3; 95% confidence interval [CI] 2.9–51.8), glaucoma (OR = 5.1; 95% CI 1.5–13.9), and congestive heart failure (OR = 5.6; 95% CI 1.4–24.2), and were more likely to be unemployed (p = 0.008) with lower annual income (p = 0.021) when compared with 46,XX controls of the same age and genetic ancestry. However, there were no differences in the rates of other encounter types, Charlson Comorbidity Index, all other medical and psychological diagnoses, military service history or quality of life metrics. In conclusion, in this aging and predominately undiagnosed sample, 47,XXX conferred few differences when compared with matched controls, offering a more reassuring perspective to the trisomy X literature.
4‐{3‐[(Pyridin‐4‐ylmethyl)amino]‐[1,2,4]triazolo[4,3‐b][1,2,4]triazin‐6‐yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator
Authors: Khatir Zahra Zakeri , Di Sotto Antonella , Percaccio Ester , Tuylu Kucukkilinc Tuba , Ercan Ayse , Chippindale Ann M. , Valipour Mehdi , Irannejad Hamid 
Published: March 2024

AbstractHepatocellular carcinoma is the most common type of primary liver cancer. However, multidrug resistance (MDR) is a major obstacle to the effective chemotherapy of cancer cells. This report documents the rational design, synthesis, and biological evaluation of a novel series of triazolotriazines substituted with CH2NH‐linked pyridine for use as dual c‐Met/MDR inhibitors. Compound 12g with IC50 of 3.06 μM on HepG2 cells showed more potency than crizotinib (IC50 = 5.15 μM) in the MTT assay. In addition, 12g inhibited c‐Met kinase at a low micromolar level (IC50 = 0.052 μM). 12g significantly inhibited P‐gp and MRP1/2 efflux pumps in both cancerous HepG2 and BxPC3 cells starting from the lower concentrations of 3 and 0.3 µM, respectively. 12g did not inhibit MDR1 and MRP1/2 in noncancerous H69 cholangiocytes up to the concentration of 30 and 60 µM, respectively. Current results highlighted that cancerous cells were more susceptible to the effect of 12g than normal cells, in which the inhibition occurred only at the highest concentrations, suggesting a further interest in 12g as a selective anticancer agent. Overall, 12g, as a dual c‐Met and P‐gp/MRP inhibitor, is a promising lead compound for developing a new generation of anticancer agents.
Synthesis of Diaryl Tellurides with Sodium Aryltellurites under Mild Conditions
Authors: Li Shan , Cao Yuan , Jiang Lvqi , Liu Jie 
Published: March 2024

AbstractA highly efficient new protocol has been developed for the formation of C−Te bonds, leading to both symmetrical and unsymmetrical diaryl tellurides. This protocol utilizes sodium aryltellurites (4), which can be easily prepared from low‐cost aryltelluride trichlorides and NaOH. The synthesis involves the use of 4 and arylazo sulfones as starting materials in the presence of (MeO)2P(O)H. A variety of diaryl tellurides are obtained in moderate to good yields using this method. Importantly, this innovative protocol eliminates the need for traditional, highly toxic aryltellurolating reagents such as diaryl ditellurides and elemental tellurium. This study will bring new vitality to the synthesis of tellurides.
Circular product design challenges: An exploratory study on critical barriers
Authors: Jugend Daniel , dos Santos Hugo Henrique , Garrido Susana , Siqueira Regiane Máximo , Mesa Jaime A. 
Published: March 2024

AbstractDespite the recognition that the adoption of the circular economy depends on aligning the new product development process with the principles of circularity, there are still few studies on the barriers to circular product design. This article aims to contribute to this topic by developing an exploratory study to identify and analyze these barriers in the Brazilian context. In addition to a theoretical analysis, the fuzzy analytic hierarchy process was utilized to evaluate the significance of various hindrances and obstacles to circular product design. To gain a better understanding of these barriers, semi‐structured interviews were also conducted. Experts in areas such as sustainability, marketing, and R&D from companies that develop products participated in this research. The results of the study reveal that the difficulties supply chains have in providing circular economy‐based products and reverse logistics systems are among the main barriers. Challenges such as low consumer valorization of these products and a lack of knowledge and technologies were also identified as relevant. By investigating a set of barriers to circular product design, this study extends knowledge about the difficulties companies face in the transition to circular business models.
EBV‐associated CNS infection in an immunocompetent adult: A case report and literature review
Authors: Srifuengfung Gwyn , Suppakitjanusant Pichatorn , Chaisrimaneepan Nattanicha 
Published: March 2024

Key Clinical MessageEBV infections rarely cause CNS involvement. For young adult patients with suspected CNS infection, bacterial and other common viral infections should be excluded first and treated empirically until proven otherwise. Challenges in diagnosing EBV‐associated CNS infection, emphasizing the role of CSF PCR in confirming the diagnosis.
Magneto‐Structural Correlation of Five‐Coordinate Trigonal Bipyramidal High Spin Cobalt(II) Complexes
Authors: Zhang Peng , Tian Yao‐Cheng , Wang Zhenxing , Lee Way‐Zen , Ye Shengfa 
Published: March 2024

AbstractHere, we combined magnetometry, multi‐frequency electronic paramagnetic resonance, and wave function based ab initio calculations to investigate magnetic properties of two high spin Co(II) complexes Co(BDPRP) (BDPRP=2,6‐bis((2‐(S)‐di(4‐R)phenylhydroxylmethyl‐1‐pyrrolidi‐nyl)methyl)pyridine, R=H for 8; R=tBu for 9). Complexes 8 and 9 featuring effective D3h symmetry were found to possess D=24.0 and 32.0 cm−1, respectively, in their S=3/2 ground states of
. Ligand field analyses revealed that the low‐lying d‐d excited states make either positive or vanishing contributions to D. Hence, total positive D values were measured for 8 and 9, as well as related D3h high spin Co(II) complexes. In contrast, negative D values are usually observed for C3v congeners. In‐depth analyses suggested that lowering symmetry from D3h to C3v induces orbital mixing between
and
and admixes excited state
into the ground state. Both factors turn the total D value progressively negative with the increasing distance (δ) of the Co(II) center out of the equatorial plane. Therefore, δ determines the sign and magnitude of final D values of five‐coordinate trigonal bipyramidal S=3/2 Co(II) complexes as measured for a series of such species with varying δ.
Corporate sustainability practices and financial performance: The moderating role of corporate controversies and Shariah screening
Authors: Lee Siew Peng , Isa Mansor 
Published: March 2024

AbstractThis study examines the effects of corporate sustainability practices (CSP) on corporate financial performance (CFP). The study also examines the moderating role of corporate controversies and shariah compliance on the CSP‐CFP relationship. The results support the positive relationship between CSP and CFP. The study also finds that corporate controversies have a negative impact on financial performance and a negative moderating role on the CSP‐CFP relationship. This study also finds that Shariah compliance has a positive moderating role but loses its power when interacting with corporate controversies in influencing the impact of the CSP‐CFP relationship. An important implication of this study is that firms affected by controversy must find ways to mitigate the negative impact.
Harmonic suppression of active disturbance rejection control for virtual synchronous generators
Authors: Lin Jican , Liu Shenquan , Wang Gang 
Published: March 2024

SummaryVirtual synchronous generators (VSGs) are comprised of an outer power loop and inner cascaded control loops. The dynamic performance of the output interface is severely degraded when microgrid loads exhibit variability and nonlinearity. Therefore, robustness against load disturbances must be possessed by any voltage control scheme. In this paper, a proportional resonance‐linear active disturbance rejection control (PR‐LADRC) scheme based on an improved linear extended state observer (ILESO) is proposed for VSG voltage control. In comparison with the traditional linear extended state observer (LESO), the differential state variable of the output voltage is utilized to increase the observation bandwidth; consequently, the proposed ILESO can effectively overcome the disadvantage of phase lag when tracking disturbances. Additionally, a proportional resonance controller is incorporated into the LESO feedforward channel to suppress voltage harmonics. The proposed scheme enhances the disturbance observation bandwidth compared to traditional strategies, resulting in a substantial improvement in both the disturbance observation capability of LADRC and the harmonic suppression ability of the VSG system. Theoretical analysis and simulations are conducted to validate the effectiveness of the proposed PR‐LADRC approach.
Study on creep deformation and energy development of underground surrounding rock under four‐dimensional support
Authors: Ma Zhanguo , Sun Junyu , Gong Peng , Yan Pengfei , Cui Nan , Zhang Ruichong 
Published: March 2024

AbstractThere is an urgent need to develop optimal solutions for deformation control of deep high‐stress roadways, one of the critical problems in underground engineering. The previously proposed four‐dimensional support (hereinafter 4D support), as a new support technology, can set the roadway surrounding rock under three‐dimensional pressure in the new balanced structure, and prevent instability of surrounding rock in underground engineering. However, the influence of roadway depth and creep deformation on the surrounding rock supported by 4D support is still unknown. This study investigated the influence of roadway depth and creep deformation time on the instability of surrounding rock by analyzing the energy development. The elastic strain energy was analyzed using the program redeveloped in FLAC3D. The numerical simulation results indicate that the combined support mode of 4D roof supports and conventional side supports is highly applicable to the stability control of surrounding rock with a roadway depth exceeding 520 m. With the increase of roadway depth, 4D support can effectively restrain the area and depth of plastic deformation in the surrounding rock. Further, 4D support limits the accumulation range and rate of elastic strain energy as the creep deformation time increases. 4D support can effectively reduce the plastic deformation of roadway surrounding rock and maintain the stability for a long deformation period of 6 months. As confirmed by in situ monitoring results, 4D support is more effective for the long‐term stability control of surrounding rock than conventional support.
Heterospecific pollen avoidance strategy prevails in the generalized plant–pollinator network on Yongxing Island
Authors: Wang Xiang‐Ping , Cai Jin‐Chao , Tong Ma‐Yin , Shi Miao‐Miao , Zhao Zhong‐Tao , Li Shi‐Jin , Tu Tie‐Yao 
Published: March 2024

AbstractHeterospecific pollen (HP) deposition varies widely among species in communities, which has been explicated by two adaptation strategies: HP avoidance and HP tolerance. Studies of the plant–pollinator network have uncovered that oceanic island communities are highly generalized and strongly connected. It remains unclear, however, which strategy prevails in such communities. We examined stigma pollen deposition on 29 plant species, and assessed patterns of HP load size and diversity in the Yongxing Island community. We assessed the effects of phenotypic specialization and species‐level network structural properties of plant species on pollen deposition among species. The hypothesis of three accrual patterns of HP within species was tested by illustrating the relationship between conspecific pollen (CP) and HP receipt. Extensive variation occurred among species in HP receipt, while 75.9% of species received less than 10% HP and one species received more than 40% HP throughout the community. Flower size strongly drives the variation of HP receipt, while network structural properties had no effect on the pollen receipt. Nineteen species showed no relationship between the number of HP and CP loads, and they received smaller HP load sizes and lower HP proportions. Most plant species evolved HP avoidance strategy, and HP receipt was an occasional event for most plant species in the generalized community. HP and CP receipts are independent of each other in plant species with the HP avoidance mechanism. Our results highlight that plants in the generalized pollination system may preferentially select to minimize the HP load on stigmas.
Adherence to heart failure treatment in patients with peripartum cardiomyopathy
Authors: Hoevelmann Julian , Sliwa Karen , Schaar Juel Maalouli , Briton Olivia , Böhm Michael , Meyer Markus R. , Viljoen Charle 
Published: March 2024

AbstractAimsPeripartum cardiomyopathy (PPCM) is characterized by left ventricular (LV) dysfunction developing towards the end of pregnancy or in the first months postpartum. Although about 60% of women with PPCM (the majority of which are prescribed evidence based heart failure [HF] medications) show LV recovery within 6 to 12 months, others remain with persistently impaired LV function. Poor adherence to medical therapy represents a major cause of avoidable hospitalizations, disability, and death in other cardiovascular conditions. In this study, we aimed to determine drug adherence to HF therapy among women with PPCM and to identify possible associations between drug adherence and LV recovery, functional status and psychological well‐being.Methods and resultsIn this single‐centre, prospective, observational study, we included 36 consecutive women with PPCM. Adherence to HF treatment was assessed by (i) verifying the collection of pharmacy refills and (ii) using liquid chromatography high‐resolution mass spectrometry (LC‐HRMS). Participants were thereby classified as ‘adherent’ (i.e. all prescribed HF drugs were detectable by LC‐HRMS), ‘partially adherent’ (i.e. at least one prescribed drug detectable) or ‘non‐adherent’ (i.e. none of the prescribed drugs detectable). Health state index scores were assessed by EQ‐5D‐5L and HADS‐A/D (for anxiety/depression). Patients' median age was 32.4 years (IQR 27.6–36.1). At the adherence visit (which occurred at a median of 16 months [IQR 5–45] after PPCM diagnosis), prescription included beta‐blockers (77.8%), angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers (75%), mineralocorticoid receptor antagonists (47.2%) and loop diuretics (95.2%). Less than two thirds of patients (63.9%) collected all their pharmacy refills in the 6 months prior to adherence visit. According to LC‐HRMS, 23.5% participants were classified as adherent, 53.0% as partially adherent, and 23.5% as non‐adherent. Adherence was associated with significantly lower LVEDD at follow‐up (47 mm [IQR 46–52), vs. 56 mm [IQR 49–64] with partial adherence, and 62 mm [IQR 55–64] with non‐adherence, P = 0.022), and higher LVEF at follow‐up (60% [IQR 41–65]), vs. partially adherence (46% [IQR 34–50]) and non‐adherence (41.0% [IQR 29–47], P = 014). Adherent patients had a lower overall EQ‐ 5D score (5.5 [IQR 5–7.5], vs. 6 [IQR 5–7] in partially adherent, and 10 [IQR 8–15] in non‐adherent patients, P = 0.032) suggestive of a better self‐rated health status.ConclusionsAdherence to HF therapy was associated with favourable LV reverse remodelling in PPCM and better self‐rated health status. Our study highlights the importance of drug adherence for functional recovery. Drug adherence should be an important component of patient communication and specific interventions in PPCM.
Enhanced S‐ARIMAX model performance and state‐of‐health prediction accuracy with battery pack degradation factor combinations
Authors: Lee Dongjae , Lee Pyeong‐Yeon , Baek Insu , Kang Deokhun , Kim Jonghoon 
Published: March 2024

AbstractThis study addresses the critical need for accurate state‐of‐health (SOH) predictions in lithium‐ion batteries, crucial for maintaining efficient battery operation and extending lifespan. We propose a novel approach utilizing the Seasonal autoregressive integrated moving average with exogenous variables (S‐ARIMAX) model, integrating multiple battery degradation factors as exogenous variables for precise SOH estimation. Our methodology involves correlation analysis to identify optimal factors, which are then incorporated into distinct cases of the S‐ARIMAX model. We evaluate the model's performance using mean absolute percentage error (MAPE) and identify voltage deviation as a highly correlated exogenous variable significantly impacting predictive accuracy. Notably, our findings underscore the S‐ARIMAX model's superiority in longer cycles, demonstrating a MAPE as low as 0.1113 at 160 cycles, emphasizing the model's adeptness at capturing cyclic patterns for precise long‐term SOH forecasts. Comparing S‐ARIMAX and ARIMAX models highlights the pivotal role of seasonality, particularly in long‐term predictions. The study's quantitative findings emphasize the necessity of integrating highly correlated variables and accounting for seasonal patterns in optimizing lithium‐ion battery SOH predictions. Our approach presents practical implications for maintaining battery performance and lifespan in electric vehicles and energy storage systems, underlining the importance of selecting strongly correlated variables and integrating seasonal components for accurate and reliable SOH forecasts.
Electricity price forecasting using quantile regression averaging with nonconvex regularization
Authors: Jiang He , Dong Yao , Wang Jianzhou 
Published: March 2024

AbstractElectricity price forecasting (EPF) is an emergent research domain that focuses on forecasting the future electricity market price both deterministically and probabilistically. EPF has attracted enormous interest from both practitioners and scholars since the deregulation of the power market and wide applications of renewable energy sources, such as wind and solar energy. However, forecasting the electricity price accurately and efficiently is an extremely challenging task because of its high volatility, randomness, and fluctuation. Although quantile regression averaging (QRA) has been demonstrated to be efficacious in probabilistic EPF since the global energy forecasting competition in 2014 (GEFCom2014), it is sensitive to nuisance variables especially when the number of variables is large. The forecasting accuracy will be negatively affected by these nuisance variables. To address these challenges, this study investigates a nonconvex regularized QRA in probabilistic forecasting. Two types of nonconvex regularized QRA select the important inputs obtained from point forecasting to obtain more accurate forecasting outcomes. To demonstrate the effectiveness of the proposed EPF model, two real datasets from the European power market are considered.
Investigating potato flour processing methods and ratios for noodle production
Authors: Buzera Ariel , Gikundi Evelyne , Kajunju Napoleon , Ishara Jackson , Orina Irene , Sila Daniel 
Published: March 2024

AbstractA partial substitution of wheat flour with potato flour processed by various procedures was used to determine an optimal potato pretreatment method for noodle processing. Wheat flour was substituted with 10%, 30%, and 50% potato flour. Potato flour (PF) was processed using two different methods, including freeze‐drying (FD) and low‐temperature blanching, then oven drying (LTB_OD). The results showed that substituting wheat flour with freeze‐dried (FD) flour (44.29 μm) significantly decreased the mean particle size of the blended flour, while LTB_OD flour (223.09 μm) increased the mean particle size. The pasting properties of wheat flour significantly improved when potato flour was added, with FD flour blends having the highest results. The highest dough development time (14.46 min) was attained when LTB_OD potato flour was substituted up to 50%. The microstructure images showed a poor and discontinuous gluten framework when potato flour content reached 50%. Adding potato flour decreased noodles' brightness (L*) while increasing their yellowness (b*). Noodles made from wheat and LTB_OD flour blends resulted in the highest cooking loss. The texture properties of noodles deteriorated when potato flour content reached 30%. Substituting up to 30% with freeze‐dried flour and 10% LTB_OD resulted in noodles with the highest overall liking scores. The study suggests that for optimal noodle processing, substituting wheat flour with FD potato flour is more favorable than using LTB_OD, as it improves particle size, pasting properties, and overall liking scores while minimizing adverse effects on texture and cooking loss.