bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterotopic Ossification of the Abdomen: A Rare Sequela Following Trauma and Damage Control Laparotomy
Authors: Cherfan Patrick , Cobler-Lichter Michael D. , Kronenfeld Joshua P. , Weiss Zoe , Byers Patricia M. 
Published: March 2024

Heterotopic ossification (HO) of the abdomen is a rare yet highly morbid complication following blunt and penetrating trauma requiring damage control laparotomy. We present the case of a 22-year-old man, 20 months after life-threatening motor vehicle crash with major vascular injury requiring multiple abdominal surgeries. The patient was initially treated at a community hospital and subsequently developed a chronic left lower quadrant enterocutaneous fistula, accompanied by a gradually worsening diffuse abdominal pain. He was referred to our tertiary care center with extensive skin breakdown and an inability to control the fistula despite numerous wound care consultations. He also had severe abdominal deformities due to HO in the abdominal wall, peritoneum, paraspinal muscles, and parapelvic regions. As HO is largely underreported, it is crucial to refer those patients, once medically stabilized, to tertiary care centers for surveillance and possible treatment when symptomatic.
Direct aortic cannulation versus femoral arterial cannulation for early outcomes in acute type A aortic dissection: A study-level meta-analysis
Authors: Yamashita Yoshiyuki , Sicouri Serge , Kjelstrom Stephanie , Montone Georgia , Dokollari Aleksander , Ridwan Khalid , Clarke Nicholas , Rodriguez Roberto , Goldman Scott M. , Ramlawi Basel 
Published: March 2024

Purpose To investigate the impact of direct aortic cannulation (DAC) versus femoral arterial cannulation (FAC) on clinical outcomes of surgery for acute type A aortic dissection. Methods PubMed/MEDLINE, Scopus, and Cochrane Central Register of Controlled Trials were searched until August 25, 2023, to conduct a meta-analysis. Primary endpoints of the study were operative mortality and postoperative stroke. Secondary endpoints were cardiopulmonary bypass time, myocardial ischemic time, hypothermic circulatory arrest time, temporary neurological dysfunction (TND), combined stroke and TND, re-exploration for bleeding, and need for renal replacement therapy. A random-effect model was used to estimate the pooled effect size, and a leave-one-out method was used for the primary endpoints for sensitivity analysis. Results 15 studies met our eligibility criteria, including a total of 7941 samples. Operative mortality was significantly lower in the DAC group with a pooled odds ratio (OR) of 0.72 [95% confidence interval (CI): 0.61–0.85)]. Incidence of postoperative stroke was also lower in the DAC group with a pooled OR of 0.79 (95% CI: 0.66–0.94). However, after excluding one study with the greatest weight, the difference became nonsignificant. DAC was also associated with a lower incidence of postoperative TND, and re-exploration for bleeding with a pooled OR of 0.52 (95% CI: 0.37–0.73), and 0.60 (95% CI: 0.47–0.77), respectively. Conclusions This meta-analysis showed that patients who underwent ATAAD repair with DAC had a lower incidence of operative mortality, postoperative stroke, TND, and re-exploration for bleeding compared to those who underwent FAC.
Relationship between SIRI and android and gynoid fat related to obesity and cardiovascular risk: a cross-sectional study of NHANES 2017–2018
Authors: Zhang Xuanchun 
Published: March 2024

Objective Inflammation has a crucial role in several metabolic diseases, such as obesity. The author aimed to investigate the relationship between the system inflammation response index (SIRI) and android fat composition and distribution. Methods Data for individuals aged 8–59 years, SIRI, android percent fat, and android-to-gynoid ratio from the 2017 to 2018 National Health and Nutrition Examination Survey were used. Weighted multiple linear regression and smooth curve fitting were used to test for linear and nonlinear associations. Additional subgroup analyses were performed. Threshold effect analysis was performed using a two-linear regression model. Results Multiple linear regression showed a positive correlation between SIRI and android percent fat (β 0.92, 95% confidence interval [CI] 0.25–1.59) and between SIRI and the android-to-gynoid ratio (β 0.01, 95% CI 0.00–0.03) in 3783 Americans aged 8–59 years. The results showed that the effect of factors, other than smoking status, on the relationship between SIRI and android percent fat and android-to-gynoid ratio was not significant. There was a nonlinear relationship between SIRI and both android percent fat and android-to-gynoid ratio. Conclusions Elevated SIRI levels were associated with an increased android percent fat and android-to-gynoid ratio. Larger prospective studies are needed to validate the findings.
Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study
Authors: GamalEl Din Sameh Fayek , Nabil Ismail Nashaat , Moawad Hanan Hosni , Adel Iten Mohamed , Motawi Ahmad , Foaad Hisham 
Published: March 2024

Objectives: We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED). Patients and methods: 30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls. Results: Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1.51, <1.51, sensitivity of 68.3%, 58.3%, specificity of 53.3%, 53.3%, lower bound of 0.558, 0.517, upper bound of 0.789, 0.757, total accuracy of 67.4%, 63.7% and p 0.003, 0.0025, respectively. Additionally, the best cut off point of pre-treatment and post treatment PLR in the ED treatment group was found <5.89, <5.99, sensitivity of 65%, 63.3%, specificity of 63.3%, 53.3%, lower bound of 0.515, 0.435, upper bound of 0.755, 0.687, total accuracy of 63.5%, 56.1% and p 0.027, 0.341, respectively. Conclusion: Daily 5 mg Tadalafil supplementation significantly improves erectile function through decreasing these markers as well as depression and anxiety.
Requirements for vibroacoustic methods of the quality assessment of vehicles traction electric motors
Authors: Migal Vasiliy , Arhun Shchasiana , Hnatov Andrii , Ulianets Olha , Shevchenko Igor 
Published: March 2024

The progression and refinement of traction electric motors play a pivotal role in the enhancement of vehicles. With constant advancements in power efficiency, diagnostic tools, and reliability, electric traction motors are becoming more economical in terms of operational costs. This article underscores the significance of methods used in assessing the technical proficiency of traction electric motors, coupled with their testing techniques. The vibration characteristics of these motors serve as a prime criterion in assessing their quality throughout their lifecycle – from design and manufacturing to operation. A groundbreaking proposition made in this article is the evaluation of electric traction motors’ health based on their vibration acceleration within an expansive frequency range of 5 Hz to 10 kHz. This contrasts the conventional approach which focuses on vibration speed in a restricted frequency spectrum up to 1000 Hz, as outlined by current standards. Such permissible vibration classes are essential in ensuring the high-quality design, technical finesse, and dependability of traction electric motors. Exceeding these vibration thresholds can result in rapid wear and tear, diminishing the motor’s reliability and lifespan. Hence, motors that surpass these permissible vibrations are not advised for vehicular use. Additionally, the article sheds light on requisite equipment controls for accurately gauging vibrations and noise levels in electric motors. Delving deeper into the nuances, the methods for mounting vibration transducers and electric motors on testing platforms are elucidated. These methods are pivotal in obliterating any hindrances that could impede the precise measurement of vibrations induced by an electric motor.
Near infrared spectroscopy for determination of moisture content in lyophilized formulation
Authors: Khanolkar Aruna , Pawale Pranita , Thorat Viraj , Patil Bhaskar , Samanta Gautam 
Published: March 2024

A non-invasive near infrared (NIR) spectroscopic method was developed for the quantitative moisture determination in a lyophilized injection formulation. The calibration samples were prepared by exposing lyophilized samples at different temperatures and relative humidity. The samples from different scales and different process parameters were considered for adding robustness to the model. The NIR spectra were collected using a Fourier-transform (FT) NIR with a diffuse reflectance probe and the same samples were further analyzed by the Karl Fisher (KF) method for moisture content. The pre-treated NIR spectra were used for quantitative method development for moisture content. Partial least squares regression was used to develop calibrations in the 5600-4950 cm−1 region with calibration coefficient of determination (R2) of 0.96 and root mean square error of calibration (RMSEC) of 0.149. The model was cross-validated internally using the Kernel algorithm with r2 = 0.96 and RMSECV = 0.15. The accuracy of the NIR method against the KF method, precision, and reproducibility were good and the model was robust in predicting different external validation samples. This work allowed NIR as an alternative measurement for moisture analysis as well as facilitate 100% monitoring before packaging and save the cost of sample and time of KF analysis.
Multimodal imaging of a case of retinal cavernous hemangioma
Authors: Guan Fanyu , Luo Wenting , Xia Guimei 
Published: March 2024

Purpose Herein, we reported a case of retinal cavernous hemangioma (RCH) and its multimodal imaging. Case presentation Many grape-like lesions were incidentally found along the distal portion of the vascular arcade in a 23-year-old man's superonasal quadrant of the retina. The best-corrected visual acuity was 20/20 in both eyes. The fluorescein angiography showed saccular lesions that slowly filled with hypofluorescence in the early stage and clusters of aneurysms with hyperfluorescence and a special “fluorescein cap” appearance in the late stage. The optical coherence tomography angiography (OCTA) B-scan revealed multilocular cavernous spaces with different sizes in the inner retinal layers, varying signals, and an epiretinal membrane. The enface OCTA of retina showed grape-like changes and multiple highly reflective signal cavities with clear and complete boundaries. Conclusion Different multimodal images are better for understanding the characteristics of RCH and more convenient for its diagnosis and follow-up.
Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?
Authors: Jolly Amy A , Brown Robin B , Tozer Daniel J , Hong Young T , Fryer Tim D , Aigbirhio Franklin I , O’Brien John T , Markus Hugh S 
Published: March 2024

Background: Fatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD. Methods: Notably, 36 patients with moderate-to-severe SVD underwent neuropsychometric testing, combined positron emission tomography and magnetic resonance imaging (PET–MRI) scan, and blood draw for the analysis of inflammatory blood biomarkers. Microglial signal was taken as a proxy for neuroinflammation, assessed with radioligand 11C-PK11195. Of these, 30 subjects had full PET datasets for analysis. We assessed global 11C-PK11195 binding and hotspots of 11C-PK11195 binding in the normal-appearing white matter, lesioned tissue, and combined total white matter. Peripheral inflammation was assessed with serum C-reactive protein (CRP) and using the Olink cardiovascular III proteomic panel comprising 92 biomarkers of cardiovascular inflammation and endothelial activation. Fatigue was assessed using the fatigue severity scale (FSS), the visual analog fatigue scale, and a subscale of the Geriatric Depression Scale. Results: Mean (SD) age was 68.7 (11.2) years, and 63.9% were male. Of these, 55.6% showed fatigue on the FSS. Fatigued participants had higher disability scores ( p = 0.02), higher total GDS scores ( p = 0.02), and more commonly reported a history of depression ( p = 0.04). 11C-PK11195 ligand binding in the white matter was not associated with any measure of fatigue. Serum CRP was significantly associated with average fatigue score on FSS (ρ = 0.48, p  = 0.004); this association persisted when controlling for age, sex, disability score, and depression (β = 0.49, 95% CI (0.17, 2.26), p = 0.03). Blood biomarkers from the Olink panel showed no association with fatigue. Conclusion: In symptomatic SVD patients, neuroinflammation, assessed with microglial marker 11C-PK11195, was not associated with fatigue. We found some evidence for a role of systematic inflammation, evidenced by an association between fatigue severity and raised CRP, but further studies are required to understand this relationship and inform whether it could be therapeutically modified to reduce fatigue severity. Data access statement: Data for this study are available from the corresponding author upon reasonable request.
Long-term survivorship of the Herbert ulnar head prosthesis: a multicentre retrospective cohort study
Authors: Maling Lucy C. , Smith Andrew M. , Williamson Mark 
Published: March 2024

Despite being in use for over 25 years, long-term data regarding the Herbert ulnar head prosthesis remain scarce. The aim of the present multicentre observational study was to describe the survivorship of this implant in the UK. Retrospective data were collected from clinical records and via telephone consultation. Data were submitted for 227 primary and five revision ulnar head prostheses. Indications for surgery included distal radioulnar joint osteoarthritis, inflammatory arthritis and failed ulnar head resection surgery. The mean follow-up was 5.5 years (range 1 month–21 years) with 91% ( n = 108) and 87% ( n = 44) survival at 5 and 10 years, respectively. Indications for reoperation included pain, instability, aseptic loosening and distal impaction. In total, 12 patients had implant removal, eight had revision arthroplasty and five underwent soft tissue stabilization. Overall, reassuring mid- to long term survivorship data for the ulnar head prosthesis were found. We recommend the use of arthroplasty registries for implant surveillance. Level of evidence: IV
Long-term outcome of the Sauvé-Kapandji procedure in patients with post-traumatic distal radioulnar joint disorders
Authors: Debeij Gijs P. , Hannemann Pascal F. W. , Ten Bosch Jan A. 
Published: March 2024

The aims of this study were to retrospectively assess the occurrence of complications or need for secondary wrist procedures after the Sauvé-Kapandji procedure, and to prospectively assess patient-reported outcomes at long-term follow-up. All patients treated with the Sauvé-Kapandji procedure in our tertiary referral hospital between January 2008 and September 2021 were identified and contacted to complete the Quick Disabilities of the Arm, Shoulder, and Hand and the Patient-Rated Wrist/Hand Evaluation outcome measures. In total, 30 patients, with a median follow-up of 82 months, were included in this study. Complications occurred in 6 of 30 patients, which resulted in six secondary wrist procedures. Mean Quick Disabilities of the Arm, Shoulder, and Hand and Patient-Rated Wrist/Hand Evaluation scores were 30.1 and 33.6, respectively. We conclude that in respect of long-term outcomes, the Sauvé-Kapandji procedure can still be deemed to be a useful procedure, especially in patients with few other reconstructive options. Level of evidence: IV
Virtual assessment and management of chronic cough: A scoping review
Authors: Pommer Alexa , Sarmento Antonio , Singer Alexander , Loewen Hal , Torres-Castro Rodrigo , Sanchez-Ramirez Diana C 
Published: March 2024

BackgroundChronic cough is a frequent reason for seeking consultation with primary care providers. The recent widespread adoption of virtual care offers a promising alternative that can be used to optimize the assessment and management of this condition. The objective of this review was to map and identify the strategies used to assess and/or manage chronic cough virtually, and to explore their impact on cough severity and patient satisfaction with virtual care.MethodsA scoping review was conducted in MEDLINE, EMBASE, and CINAHL in May 2023. Research questions were defined based on the Population, Concept, Context mnemonic, and literature search was conducted using a three-step approach. Study selection involved the steps of identification, screening, eligibility, and inclusion. A descriptive synthesis was performed, and quantitative variables were presented as absolute and relative frequencies.ResultsA total of 4953 studies were identified and seven met the inclusion criteria. The following mHealth and telehealth strategies were identified: diagnostic website, specialized online clinic, online speech language therapy, and remote follow-up to assess the effectiveness of in-person interventions. Results indicated that these virtual strategies can be useful to assess chronic cough, treat, and track chronic cough symptoms. Overall, patients were satisfied with the approaches.ConclusionAlthough literature is scarce, evidence suggests that virtual strategies for the assessment and management of chronic cough may be effective and are well-received by patients. However, further research is needed to identify the type and characteristics of virtual approaches leading to optimize and facilitate the care of patients with this condition. This will also help develop a strong body of evidence to support their incorporation into guidelines and clinical practice.
Causes of Intraoperative Neuromonitoring Events in Adult Spine Deformity Surgery: A Systematic Review
Authors: Cottone Chloe , Kim David , Lucasti Christopher , Scott Maxwell M. , Graham Benjamin C. , Aronoff Nell , Hasanspahic Bilal , Kowalski David , Bird Justin , Patel Dil 
Published: March 2024

Study Design Systematic review. Objectives Intraoperative neuromonitoring (IOMN) has become a standard practice in the detection and prevention of nerve damage and postoperative deficit. While multicenter studies have addressed this inquiry, there have been no systematic reviews to date. This systematic review identifies the leading causes of IONM alerts during adult spinal deformity (ASD) surgeries. Methods Following PRISMA guidelines, a literature search was performed in PubMed and Embase. IONM alert causes were grouped by equivalent terms used across different studies and binned into larger categories, including surgical maneuver, Changes in blood pressure/temperature, Oxygenation, Anesthesia, Patient position, and Unknown. Results Inclusion criteria were studies on adult patients receiving ASD correction surgery using IONM with documented alert causes. 1544 references were included in abstract review, 128 in full text review, and 16 studies qualified for data extraction. From those studies, there was a total of 3945 adult patients with 299 IONM alerts. Surgical maneuver led the alert causes (258 alerts/86.3%), with signal loss most commonly occurring at correction or osteotomy (101/33.8% and 95/31.8% respectively). Pedicle screw placement caused 35 alerts (11.7%). Changes in temperature and blood pressure were the third largest category (34/11.4%). Conclusions The most frequent causes of IONM alerts in ASD surgery were surgical maneuvers such as correction, osteotomy, and pedicle screw placement. This information provides spine surgeons with a quantitative perspective on the causes of IONM changes and show that most occur at predictable times during ASD surgery.
Obsessive-Compulsive Disorder: A Medical School Curriculum and Textbook Review
Authors: Lahey Chelsea A. , Fawcett Emily J. , Pevie Noah , Seim Rowan B. , Fawcett Jonathan M. 
Published: March 2024

OBJECTIVES We conducted a curriculum review of Canadian undergraduate medical programs to identify why aggressive obsessions (among those with obsessive-compulsive disorder [OCD]) are so often misidentified by primary care physicians and professional students. METHODS This study involved standardized interviews with representatives from Canadian medical schools regarding the content, time, and teaching styles used to deliver curricula related to OCD. Further, we utilized a set of standardized criteria to assess the OCD content of recommended textbooks from these schools. RESULTS Canadian medical curricula failed to provide a comprehensive picture of OCD. One-third of medical programs did not provide an example of aggressive obsessions to students, with textbook case examples centered heavily (70%) on contamination or symmetry. Only 25% of programs (and 60% of textbooks) discussed the composition of the Unacceptable Thought Domain to include aggressive, sexual, and religious obsessions. Finally, over half of medical programs failed to indicate that aggressive obsessions are ego-dystonic and do not lead people to harm themselves or others. CONCLUSION A series of recommendations are provided for medical schools intended to improve the comprehensiveness of OCD-related training.
Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study
Authors: Zammitti Christopher , Tisminetzky Mayra , Mehawej Jordy , Abu Hawa O , Miozzo Ruben , Gore Joel M , Lessard Darleen , Bamgbade Benita A , Yarzebski Jorge , Gurwitz Jerry H , Goldberg Robert J 
Published: March 2024

Background Multiple chronic conditions (MCCs) are common in patients hospitalized with acute myocardial infarction (AMI). We examined the association of 12 MCCs with the risk of a 30-day hospital readmission and/or dying within one year among those discharged from the hospital after an AMI. We also examined the five most prevalent pairs of chronic conditions in this population and their association with the principal study endpoints. Methods The study population consisted of 3,294 adults hospitalized with a confirmed AMI at the three major medical centers in central Massachusetts on an approximate biennial basis between 2005 and 2015. Patients were categorized as ≤1, 2-3, and ≥4 chronic conditions. Results The median age of the study population was 67.9 years, 41.6% were women, and 15% had ≤1, 32% had 2-3, and 53% had ≥4 chronic conditions. Patients with ≥4 conditions tended to be older, had a longer hospital stay, and received fewer cardiac interventional procedures. There was an increased risk for being rehospitalized during the subsequent 30 days according to the presence of MCCs, with the highest risk for those with ≥4 conditions. There was an increased, but attenuated, risk for dying during the next year according to the presence of MCCs. Individuals with diabetes/hypertension and those with heart failure/chronic kidney disease were at particularly high risk for developing the principal study outcomes. Conclusion Development of guidelines that include complex patients, particularly those with MCCs and those at high risk for adverse short/medium term outcomes, remain needed to inform best treatment practices.