bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating factors influencing utilization of trauma-focused cognitive behavioral therapy among unaccompanied young refugees: an exploratory analysis
Authors: Kasparik Barbara , Farani Madina , Pfeiffer Elisa , Sachser Cedric , Rosner Rita 
Published: February 2025

Abstract

Background
Unaccompanied young refugees (UYRs) exhibit elevated levels of mental distress, including posttraumatic stress symptoms (PTSS), depression and anxiety. Despite the considerable psychological burden, UYRs frequently lack access to mental health care (MHC). The factors that contribute to higher rates of treatment utilization among UYR remain poorly understood. Untreated PTSS can result in chronic impairment, underscoring the importance of identifying these factors. The aim of this study is to investigate factors associated with the intention and actual utilization of MHC of UYRs living in child and youth welfare facilities in Germany.

Method
This study is part of the multi-site project BETTER CARE which aims to implement a stepped and collaborative care approach. A sample of N = 139 UYRs who had received a treatment recommendation for trauma-focused cognitive behavioral therapy (TF-CBT) was analyzed. Binomial logistic regression was performed to identify factors predicting the likelihood of intention to seek MHC. In addition, the association between intention to seek MHC and actual utilization was determined using a chi square test.

Results
The results demonstrated a significant correlation between age (η = 0.25, p <.01), length of stay in Germany (η = 0.28, p <.01), and severity of PTSD symptoms (η = 0.26, p <.01) with intention to use MHC. In the logistic regression analysis, PTSD emerged as a significant predictor of intended use (B = 2.66, p <.05). The utilization of MHC was found to be closely associated with the initial intention to use (χ²(1) = 88.846, p <.001).

Conclusions
The findings contribute to an expanding body of literature on the mental health requirements and service utilization patterns among UYRs, offering insights for policymakers, mental health professionals, and child welfare services striving to enhance care for this vulnerable population.
Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer
Authors: Zhang Siyue , Zhang Ning , Wan Tong , He Yinqiao , Hao Jie , Liu Yiwei , Liu Yidong , Chen Bing , Zhao Wenjing , Wang Lijuan , Luo Dan , Gao Chao , Yang Qifeng 
Published: February 2025

Abstract

Background
D-2-hydroxyglutarate (D-2HG), an oncometabolite derived from the tricarboxylic acid cycle. Previous studies have reported the diverse effects of D-2HG in pathophysiological processes, yet its role in breast cancer remains largely unexplored.

Methods
We applied an advanced biosensor approach to detect the D-2HG levels in breast cancer samples. We then investigated the biological functions of D-2HG through multiple in vitro and in vivo assays. A joint MeRIP-seq and RNA-seq strategy was used to identify the target genes regulated by D-2HG-mediated N6-methyladenosine (m6A) modification. RNA pull-down assays were further applied to identify the reader that could specifically recognize the m6A modification on angiopoietin like 4 (ANGPTL4) mRNA and RNA immunoprecipitation was used to confirm the findings.

Results
We found that D-2HG accumulated in triple-negative breast cancer (TNBC), exerting oncogenic effects both in vitro and in vivo by promoting TNBC cell growth and metastasis. Mechanistically, D-2HG enhanced global m6A RNA modifications in TNBC cells, notably upregulating m6A modification on ANGPTL4 mRNA, which was mediated by the inhibition of Fat-mass and obesity-associated protein (FTO), resulting in increased recognition of m6A-modified ANGPTL4 by YTH N6-methyladenosine RNA binding protein F1 (YTHDF1), thereby promoting the enhanced translation of ANGPTL4. As a secretory protein, ANGPTL4 subsequently activated the integrin-mediated JAK2/STAT3 signaling cascade in TNBC cells through autocrine signaling. Notably, the knockdown of ANGPTL4 or treatment with GLPG1087 (an integrin antagonist) significantly reduced D-2HG-induced proliferation and metastasis in TNBC cells. Additionally, ANGPTL4 was found to promote macrophage M2 polarization within the tumor microenvironment via paracrine signaling, further driving TNBC progression. The association of ANGPTL4 with poor prognosis in TNBC patients underscores its clinical relevance.

Conclusions
Our study unveils a previously unrecognized role for D-2HG-mediated RNA modification in TNBC progression and targeting the D-2HG/FTO/m6A/ANGPTL4/integrin axis can serve as a promising therapeutic target for TNBC patients.
Language learners’ surface, deep, and organizing approaches to ChatGPT-assisted language learning: What contextual, individual, and ChatGPT-related factors contribute?
Authors: Rahimi Amir Reza , Mosalli Zahra 
Published: February 2025

Abstract
Researchers have significantly explored language learners' attitudes toward ChatGPT through the lens of technology acceptance models, particularly with its development and integration into computer-assisted language learning (CALL). However, further research in this area is necessary to apply a theoretical framework with a pedagogical-oriented perspective. Therefore, in this study, the researchers utilized students' approaches to the learning environment (SAL) and extended it by incorporating a multilevel perspective that encompasses contextual, individual, and ChatGPT-related factors. Accordingly, the researchers integrated ChatGPT into their language syllabus and guided learners in three universities in Ardabil City to use ChatGPT during the academic year 2023–2024. In the end, 214 participants answered the study questionnaire. The result of the partial least squares modeling (PLS-SEM), and Importance performance map analysis (IPMA) showed that ChatGPT leadership, where the university executive provides the atmosphere for the norms of ChatGPT integration, could significantly shape language learners’ organizing approach to using it in their daily academic schedule. Additionally, personalization and anthropomorphism were among the significant ChatGPT-related factors that shaped learners’ deep approach to using ChatGPT as a source for meaningful, cross-referenced CALL tool. However, low feedback reliability, privacy concerns, and the ChatGPT's perceived value contributed to language learners' surface approach to minimizing its use as a ChaGPT-related factor. On the basis of these findings, the study introduces a new conceptual framework for CALL and artificial intelligence language learning (AILL) and suggests that ChatGPT leadership should be promoted at a macro-contextual level that might cover other micro-contextual, personal, and ChatGPT-related factors, including ChatGPT's price-value, personalization, and language learners' motivation, which are important elements to shape learners' approaches to CHAGPTALL.
Current status of developed electrocatalysts for water splitting technologies: from experimental to industrial perspective
Authors: Tran Duy Thanh , Tran Phan Khanh Linh , Malhotra Deepanshu , Nguyen Thanh Hai , Nguyen Tran Thien An , Duong Nguyen Tram Anh , Kim Nam Hoon , Lee Joong Hee 
Published: February 2025

Abstract
The conversion of electricity into hydrogen (H2) gas through electrochemical water splitting using efficient electrocatalysts has been one of the most important future technologies to create vast amounts of clean and renewable energy. Low-temperature electrolyzer systems, such as proton exchange membrane water electrolyzers, alkaline water electrolyzers, and anion exchange membrane water electrolyzers are at the forefront of current technologies. Their performance, however, generally depends on electricity costs and system efficiency, which can be significantly improved by developing high-performance electrocatalysts to enhance the kinetics of both the cathodic hydrogen evolution reaction and the anodic oxygen evolution reaction. Despite numerous active research efforts in catalyst development, the performance of water electrolysis remains insufficient for commercialization. Ongoing research into innovative electrocatalysts and an understanding of the catalytic mechanisms are critical to enhancing their activity and stability for electrolyzers. This is still a focus at academic institutes/universities and industrial R&D centers. Herein, we provide an overview of the current state and future directions of electrocatalysts and water electrolyzers for electrochemical H2 production. Additionally, we describe in detail the technological framework of electrocatalysts and water electrolyzers for H2 production as utilized by relevant global companies.

Graphical Abstract
A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research
Authors: Ebert Max L. A. , Schmidt Vanessa F. , Öcal Osman , von Thaden Anne , Dietrich Olaf , Popper Bastian , Elges Sandra , Seidensticker Max , Ricke Jens , Kimm Melanie A. , Jeibmann Astrid , Wildgruber Moritz 
Published: February 2025

Abstract

Background
A variety of animal models has been developed for research on atherosclerosis and neointimal hyperplasia. While small animal models contain limits for translational research, we aimed to develop an atherosclerosis model with lumen-narrowing plaques to foster basic research in vascular biology, the development of new angioplasty devices, and vessel wall imaging approaches.

Methods
Endothelial denudation was performed via a minimally invasive approach through the auricular artery, followed by stent-retriever mediated endothelial injury in New Zealand White rabbits (n = 10). Along with a high-fat diet, the rabbits developed lumen-narrowing atherosclerosis and neointimal hyperplasia of the iliac arteries within a 6-week period after mechanical injury. The stent-retriever method was compared with a conventional rabbit model (n = 10) using balloon denudation via surgical access, and both models were analyzed with a particular focus on animal welfare. Fisher’s exact, Mann–Whitney U, and unpaired t-tests were used.

Results
The average time for the entire procedure was 62 min for the balloon group and 31 min for the stent-retriever group (p < 0.001). The stent-retriever model resulted in less periprocedural morbidity (including expenditure, intubation time, anesthetics, and end-tidal CO2 level) and mortality (40% mortality in the conventional group compared to 0% in the stent-retriever model, p = 0.011), while generating lumen-narrowing atherosclerotic lesions with key features as compared to humans as revealed by time-of-flight magnetic resonance imaging and histology.

Conclusion
We developed a minimally invasive model of iliac atherosclerosis with high reproducibility and improved animal welfare for translational research.

Relevance statement
This advanced rabbit model could allow for translational research in atherosclerosis, including pharmacological investigations as well as research on interventional angioplasty procedures.

Key Points

Rabbit models show similar lipid metabolism as humans.

Stent-retriever mediated endothelial denudation causes neointimal hyperplasia and lumen narrowing.

This minimal invasive model allows for clinical translation, including pharmacological investigations and vessel wall imaging.

Graphical Abstract
Comparative review of transcortical and trans-Sylvian approaches for surgical resection of giant insular gliomas: outcomes and challenges
Authors: Hamissou Moussa Maman Roufai , Agila Rafeq 
Published: February 2025

Abstract
The giant insular glioma is defined as occupying all zone of the insula according to the Berger-Sanai classification. It is often encountered with a large volume, extending to the surrounding areas, functional pathway, and vascular structure, making its surgical resection very challenging for a neurosurgeon. In the literature, some studies revealed that it is more likely not to achieve a great extent of resection and is associated with a high postoperative morbidity rate. However, those studies included different insular gliomas regarding the location, extension, and surgical approach addressed. The giant insular gliomas subtype has been reported in the literature combined with all the insular gliomas and different surgical methods, which may bias the outcomes. The main approaches for insular glioma surgery are transcortical (TC) and trans-Sylvian (TS) approaches. This review aims to evaluate the evidence supporting the use of TS and TC surgical approaches for the management of giant insular gliomas. It will also analyze the associated postoperative outcomes to provide insights into their effectiveness and safety.
Exploring the intricate relationship between public debts and economic development in Nigeria
Authors: Amu Christian Ugwueze , Kanu Success Ikechi , Akuwudike Hilary Chinedu , Okere Kingsley Ikechukwu 
Published: February 2025

Abstract
This study was carried out to ascertain the relationships between public debts and economic development in Nigeria. The specific objectives were to assess the effects of public debt on economic growth rate, aggregate demands, sectoral compositions and to find out if there exists any threshold relationship between debt accumulation and economic development in Nigeria. An ex-post facto research design was adopted in the study. With the aid of E-view statistical package, varied econometric analyses were conducted. Outcome of the study indicates that there exists a significant threshold relationship of between 50 and 60 percent for external debt, while a 15–17 percent threshold was established for domestic debt and debt accumulation in Nigeria. The study also reveals that external and domestic debts both have significant and largely negative impact on economic growth and development in Nigeria. The study therefore recommends that there is need for government at various levels in Nigeria to strive to reduce debt accumulation, especially in the long run by expanding her tax drag nets where necessary for overall and effective public financial management. There is also the need for a strong support for fiscal operations. Debt dependence in Nigeria was identified as a problem of fiscal federalism and claims to resource control among the federating units. It is also recommended that government must provide support for fiscal discipline. This could pave way for effective debt management practice in Nigeria.
Coral snake envenomation induced acute pancreatitis
Authors: Sajjad Erum , Sami Sumayya , Khanum Iffat 
Published: February 2025

Abstract

Background
Coral snakes belong to the elapid group. They are venomous and are highly neurotoxic, but their bites are not considered lethal to life. We describe a case of coral snake poisoning leading to acute pancreatitis, which is a very rare complication reported in literature after snake envenoming.

Case presentation
A young female patient presented with complaints of generalized weakness, muscle spasms, and respiratory distress after the coral snake bite 1 day ago. She had bilateral ptosis and muscle power of 3/5 in all her limbs at the time of presentation for which she received anti-venom along with low-dose intravenous neostigmine in our hospital which improved her ptosis and muscle weakness gradually over 3 days. On day 4th of her admission, she developed severe generalized abdominal pain and tenderness in the epigastrium. Acute pancreatitis was diagnosed after appropriate investigations which was treated with supportive therapy, and the patient improved clinically.

Conclusion
Acute pancreatitis after coral snake envenomation is a rare and serious complication. Timely identification and initiation of appropriate management can improve clinical outcome of the patient.
Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10
Authors: Zhu Jiaojiao , Hou Yanting , Yu Wei , Wang Jingzhou , Chu Xiaolong , Zhang Xueting , Pang Huai , Ma Dingling , Tang Yihan , Li Menghuan , Yuan Chenggang , Xie Jianxin , Wang Cuizhe , Zhang Jun 
Published: February 2025

Abstract
Type 2 diabetes mellitus (T2DM) has rapidly increased worldwide, emerging as the fifth leading cause of death. The treatment of T2DM is challenging due to the side effects of oral hypoglycemic drugs and the limited efficacy of long-term insulin therapy, which can lead to insulin resistance (IR). Consequently, there is significant in discovering new drugs that have minimal side effects and a pronounced hypoglycemic effect. In obesity, microRNA levels have been implicated in glucose metabolism disorders and T2DM, although many aspects remain unresolved. Here, we confirmed that visceral adipose tissue and serum microRNA-450a-5p content increased under obesity and T2DM, and it was significantly positively associated with fasting blood glucose, triglycerides, cholesterol, low-density lipoproteins-cholesterol levels of the subjects. In high-fat diet (HFD)-induced obese mice, microRNA-450a-5p expression was increased in the serum, liver, and white adipose tissue. Moreover, the adipose Dicer-knockout mouse model was constructed to identify adipose tissue as the main source of microRNA-450a-5p. microRNA-450a-5p could inactivate the insulin signal pathway by targeting the inhibited Dual Specificity Phosphatase 10 (DUSP10) and inducing IR and glucose metabolism disorders in vitro cultured hepatocytes and adipocytes. Additionally, microRNA-450a-5p was found to regulate DUSP10 expression and insulin signaling activity, influencing glucose tolerance and insulin sensitivity across various models, including normal diet, HFD-induced obese, adipose tissue-specific microRNA-450a-5p-knockout, and db/db mice. Furthermore, gallic acid might play a potential role in inhibiting glucose levels by decreasing microRNA-450a-5p expression. Thus, microRNA-450a-5p emerges as an attractive therapeutic target for addressing obesity, IR, and T2DM.
LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects
Authors: Wu Ruolan , Li Huilong , Wu Pingyun , Yang Qi , Wan Xueting , Wu Yuan 
Published: February 2025

ABSTRACT
Leucine Rich Repeat Containing protein 56 (LRRC56), also known as DNAAF12, is a member of the LRRC superfamily, whose dysfunction is associated with mucociliary clearance and laterality defects in humans. Here, we generated LRRC56-knockout mice using the CRISPR/Cas9 nuclease system to specifically target exons 4-5 of the LRRC56 gene. We observed that homozygous LRRC56 gene deletion is definitely deleterious, as 27.8% of LRRC56−/− mice died before adulthood. Among the surviving LRRC56−/− mice, the most prominent phenotypes included hydrocephalus, situs inversus, male infertility, and bronchiectasis. Transmission electron microscopy revealed defects in dynein arms of cilia and disorganized axonemal structure in flagella. Immunofluorescence analysis similarly revealed the absence of inner and outer dynein arm markers DNALI1 and DNAI2 in the cilia. Heterozygous LRRC56+/− mice developed normally, without exhibiting any symptoms of primary ciliary dyskinesia. In conclusion, the knockout of the LRRC56 gene in mice leads to a range of conditions consistent with primary ciliary dyskinesia. The absence of DNALI1 and DNAI2 signaling in knockout mouse cilia supports the critical role of the LRRC56 gene in dynein arm assembly.
Quality of information in gestational diabetes mellitus videos on TikTok: Cross-sectional study
Authors: Jiang Genyan , Chen Lei , Geng Lan , Zhang Yuhan , Chen Zhiqi , Zhu Yaqi , Ma Shuangshuang , Zhao Mei 
Published: February 2025

Background
TikTok is an important channel for consumers to obtain and adopt health information. However, misinformation on TikTok could potentially impact public health. Currently, the quality of content related to GDM on TikTok has not been thoroughly reviewed.

Objective
This study aims to explore the information quality of GDM videos on TikTok.

Methods
A comprehensive cross-sectional study was conducted on TikTok videos related to GDM. The quality of the videos was assessed using three standardized evaluation tools: DISCERN, the Journal of the American Medical Association (JAMA) benchmarks, and the Global Quality Scale (GQS). The comprehensiveness of the content was evaluated through six questions covering definitions, signs/symptoms, risk factors, evaluation, management, and outcomes. Additionally, a correlational analysis was conducted between video quality and the characteristics of the uploaders and the videos themselves.

Results
A total of 216 videos were included in the final analysis, with 162 uploaded by health professionals, 40 by general users, and the remaining videos contributed by individual science communicators, for-profit organizations, and news agencies. The average DISCERN, JAMA, and GQS scores for all videos were 48.87, 1.86, and 2.06, respectively. The videos uploaded by health professionals scored the highest in DISCERN, while the videos uploaded by individual science communicators scored significantly higher in JAMA and GQS than those from other sources. Correlation analysis between video quality and video features showed DISCERN scores, JAMA scores and GQS scores were positively correlated with video duration (P<0.001). Content scores were positively correlated with the number of comments (P<0.05), the number of shares (P<0.001), and video duration (P<0.001).

Conclusion
We found that the quality of GDM video on TikTok is poor and lack of relevant information, highlighting the potential risks of using TikTok as a source of health information. Patients should pay attention to identifying health-related information on TikTok.
Machine learning identifies the association between second primary malignancies and postoperative radiotherapy in young-onset breast cancer patients
Authors: Lai Yulin , Huang Peiyuan 
Published: February 2025

Background
A second primary malignant tumor is one of the most important factors affecting the long-term survival of young women with breast cancer (YWBC). As one of the main treatments for breast cancer YWBC patients, postoperative radiotherapy (PORT) may increase the risk of second primary malignancy (SPM).

Methods
Machine learning components, including ridge regression, XGBoost, k-nearest neighbor, light gradient boosting machine, logistic regression, support vector machine, neural network, and random forest, were used to construct a predictive model and identify the risk factors for SPMs with data from the Surveillance, Epidemiology and End Results. Multivariate logistic regression analysis was used to assess the risk of SPM associated with PORT. The cumulative incidence of SPMs was determined by competing risk regression analysis.

Results
Among the 44223 YWBC patients included in our study, 3017 developed SPMs. Among all the clinical characteristics, PORT was the most common SPM. YWBC patients receiving PORT had significantly greater risks of second primary solid malignancies (SPSMs, RR = 1.61), including breast cancer (RR = 1.89), lung cancer (RR = 2.12) and thyroid cancer (RR = 1.48), but not second primary hematologic malignancies (RR = 1.32; 0.94–1.88). SPSMs were more common in YWBC individuals who were black, had a lower median household income and had fewer lymph nodes examined. Additionally, we developed a prediction nomogram with an area under the curve of 0.75 to assess the likelihood of developing SPMs.

Conclusion
YWBC patients receiving PORT had a greater risk of developing SPSMs (thyroid, lung, and breast cancer), indicating the necessity of long-term surveillance of these patients. Standard adjuvant PORT should not be recommended for breast cancer patients with favorable histology and a low risk of relapse.