bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actions speak louder than words: modifications of the applied academic books and their reflections on students’ academic success, academic enjoyment, and academic resilience
Authors: Matar Hasan Alharbi Wael 
Published: March 2024

AbstractInnovation is the process of renewing and updating a domain, a product, or a service by introducing new methods, introducing new techniques, or generating effective concepts to produce new value. Considering universal as well as local books, a teacher may find some sections that need modifications and supportive sections. These changes may have an impact on language learners’ emotional and/or cognitive development. The purpose of this research was to shed light on the use of creative activities and their consequences on academic enjoyment, academic resilience, and academic performance. To that purpose, two groups of EFL (English as a foreign language) learners from Saudi Arabia (public schools) participated in this research and were requested to take pre-and post-tests to assess their level of academic engagement, academic resilience, and academic performance in language skills. According to the data analysis via the Multivariate Analysis of Variance (MANOVA), the experimental group outperformed their counterparts in the control group in terms of academic enjoyment, resilience, and academic performance due to considered modifications in the applied academic books. The study’s pedagogical ramifications are highlighted in the conclusion.
Assessment of perineural spread in advanced cutaneous squamous cell carcinomas treated with immunotherapy
Authors: Cavanagh Karda , McLean Luke S. , Lim Annette M. , Cardin Anthony , Levy Sidney M. , Rischin Danny 
Published: March 2024

Abstract
Background
Cutaneous squamous cell carcinoma (CSCC) has a propensity for perineural spread (PNS) which is associated with poorer treatment outcomes. Immunotherapy is the new standard of care treatment for advanced CSCC resulting in durable responses. PNS is not captured by traditional response assessment criteria used in clinical trials, e.g. RECIST 1.1, and there is limited literature documenting radiological PNS responses to immunotherapy. In this study we assess PNS responses to immunotherapy using a modified grading system.

Methods
This is an Australian single-center retrospective review of patients with advanced CSCC who were treated with immunotherapy between April 2018 and February 2022 who had evidence of PNS on pre-treatment magnetic-resonance imaging (MRI). The primary outcome was blinded overall radiological response in PNS using graded radiological criteria, post-commencement of immunotherapy. Three defined timepoints (< 5 months, 5–10 months, > 10 months) were reviewed. Secondary outcomes included a correlation between RECIST 1.1 and PNS assessments and the assessment of PNS on fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT).

Results
Twenty CSCC patients treated with immunotherapy were identified. Median age was 75.7 years and 75% (n = 15) were male. All patients had locoregionally advanced disease and no distant metastases. Median follow-up was 18.5 months (range: 2–59). 70% (n = 14) demonstrated a PNS response by 5 months. Three patients experienced pseudoprogression. One patient had PNS progression by the end of study follow up. RECIST 1.1 and PNS responses were largely concordant at > 10 months (Cohen’s Kappa 0.62). 5/14 cases had features suspicious for PNS on FDG-PET/CT.

Conclusions
PNS response to immunotherapy can be documented on MRI using graded radiological criteria. High response rates were seen in PNS with the use of immunotherapy in this cohort and these responses were largely concordant with RECIST 1.1 assessments. FDG-PET/CT demonstrated limited sensitivity in the detection of PNS.
Optimizing organically nano-fabricated Ni metal complexes for enhanced antioxidant and anticancer activity using response surface methodology
Authors: Aleti Swathi , Belwal Savita , Medala Mukunda Vani 
Published: March 2024

Abstract
Background
Researchers, prompted by the toxicity and side effects associated with cisplatin, are exploring alternative approaches for developing transition metal-based anticancer agents. Employing a green biochemical approach, we transformed Nickel pyridine dicarboxylic acid compounds into the nanoscale using the aqueous extract of Macrotyloma uniflorum (horse gram).

Results
Characterization of the biosynthesized nanoparticles involved electronic and IR spectroscopy. A scanning electron microscope revealed a predominant spherical shape for most Nickel nanoparticles (Ni-NPs), with XRD patterns indicating particle sizes ranging from approximately 30–150 nm. The nanoparticles were evaluated for their free radical scavenging efficiency and in vitro anti-malignant properties against HeLa and A549 cancer cell lines. Numerical optimization of the DPPH and MTT assays was conducted using response surface methodology (RSM), focusing on the effects of 3,4-pyridine dicarboxylic acid (ML1), 2,4-pyridine dicarboxylic acid (ML2), nickel nanoparticles concentration, and temperature. In this investigation, the incorporation of Horse Gram seed extract (Macrotyloma uniflorum) has unveiled its abundance in phenolic and flavonoid compounds, widely acknowledged for their robust antioxidant activity in the existing literature.

Conclusion
The present study highlights the potential for refining the bio-toxicity and biochemical attributes of Ni-NPs to pave the way for a new generation of versatile anticancer agents with clinically established efficacy. Notably, the anticipated data closely corresponds with experimental outcomes, reinforcing the trustworthiness and validity of the RSM model for examining anticancer and antioxidant properties in this context. ML2 exhibited heightened antioxidant and anticancer activities in comparison to ML1 nanoparticles.

Graphical abstract
Adapting a coach-assisted web-based intervention for parents of adolescents who refuse school: qualitative study with users of the Partners in Parenting Plus programme
Authors: Smout Anna , Melvin Glenn , Jorm Anthony , Yap Marie B. H. 
Published: March 2024

Background
School refusal is a heterogenous problem which typically emerges in adolescence and co-occurs with internalising disorders. A substantial proportion of adolescents do not respond to existing treatment modalities; thus, novel, effective intervention options are needed. Partners in Parenting Plus (PiP+) is a coach-assisted, web-based intervention designed to empower parents to respond to adolescent internalising disorders.

Aims
To conduct a process evaluation of PiP+ and identify programme adaptations required to meet the needs of parents of adolescents who refuse school.

Method
Semi-structured interviews were conducted with 14 Australian mothers who had: (a) received the PiP+ programme (not tailored for school refusal) during a prior research trial; and (b) reported that their adolescent was refusing school during their participation in PiP+. Inductive thematic analysis was used to analyse interview transcripts.

Results
Participants were 41–53 years old (M = 47.8) and parenting adolescent children aged 14–17 years (M = 14.9). Three themes illustrated how PiP+ features met or could better meet the needs of parents of adolescents who were refusing school: (a) feeling heard, supported and respected; (b) relevance to me and my context; and (c) seeing positive changes. Participants had favourable views of PiP+, especially coached components. Participants requested programme enhancements to better meet the needs of parents of neurodiverse adolescents and discussed the impact of cumulative help-seeking ‘failures’ on self-efficacy and locus of control.

Conclusions
PiP+ was highly acceptable to the majority of parents navigating the issue of school refusal. This has implications for the enhancement of coach-assisted parenting interventions and the context-specific adaptation of PiP+ for school refusal.
Adiponectin Inhibits the Progression of Obesity-Associated Papillary Thyroid Carcinoma Through Autophagy
Authors: Li Changlin , Zhang Jiao , Dionigi Gianlorenzo , Liang Nan , Guan Haixia , Sun Hui 
Published: March 2024

Abstract

Context
Obesity is a risk factor for the development of papillary thyroid cancer (PTC). However, the molecular mechanisms by which obesity promotes PTC are unclear.

Objective
This study aims to identify adipokines that are linked to PTC progression.

Methods
An adipokine antibody array was used to determine the serum levels of 40 adipokines in normal-weight and obese PTC patients. Enzyme-linked immunosorbent assay was used to determine the serum levels of adiponectin. Recombinant human adiponectin was produced by human adipose-derived stem cells and used to treat PTC cells. Cell proliferation and migration were evaluated using the CCK8 and Transwell assays. Bioinformatics analysis was used to predict mechanisms by which adiponectin affects PTC.

Results
Adipokines differentially expressed between normal-weight and obese patients showed a gender-dependent pattern. Obese PTC patients had a significantly lower serum adiponectin level than normal-weight patients, especially in female individuals. Adiponectin levels were negatively correlated with aggressive features of PTC, including tumor diameter &gt; 1 cm, extrathyroidal extension, and lymph node metastasis. Recombinant human adiponectin inhibited the proliferation and migration of human PTC cells in vitro. Bioinformatics analysis identified adiponectin receptor 2 (ADIPOR2) and the autophagy pathway as possible mediators of adiponectin function in TC. In vitro experiments confirmed that adiponectin activated autophagy in PTC cells. These findings shed new lights into the role and mechanisms of adiponectin in TC pathogenesis.

Conclusion
Adiponectin is involved in development of obesity-related PTC. Adiponectin can directly inhibit thyroid cancer growth and metastasis through the autophagy pathway.
100 What Are We Transfusing? A Prospective Trial Evaluating the Quality of Intraoperatively Salvaged Red Blood Cells in Spinal Deformity Surgery
Authors: Kurland David B. , Alber Daniel Alexander , Lau Darryl 
Published: March 2024

INTRODUCTION:
Intraoperative RBC salvage (aka Cell Saver) is widely employed in spinal deformity surgery. Unlike other surgical subspecialities wherein blood is immediately salvaged (with low potential RBC injury), modern approaches to spine surgery inherently result in collection of blood exposed to high-heat electrocautery, prolonged stasis, and abrasive pharmaceuticals, potentially resulting in RBC injury. However, this has not been studied in a scientific manner.

METHODS:
Patients undergoing spinal deformity surgery with Cell Saver were prospectively enrolled (N = 86). Comparison blood samples include baseline (arterial-line), allogenic (blood bank), and salvage (Cell Saver transfusate). Qualitative laboratory measures of RBC health and hemolysis were collected. Morphological assessment utilized Stimulated Raman Histology (SRH) and artificial intelligence based machine-learning algorithm. Functional RBC evaluation was measured via ektacytometry.

RESULTS:
Salvage blood differed significantly from baseline and allogenic blood, including an unpredictable range of RBC density (2.11-9.52 x 1000/uL), and significantly lower MCV (smaller RBCs) vs. baseline and allogenic samples (p = 0.015 and 4.05E-8, respectively). SRH revealed a high proportion (30.7%) of often irreversibly injured acanthocytes (shrunken and irregularly spiculated RBCs). Ektacytometry revealed that salvaged RBCs were poorly deformable and had impaired relaxation kinetics. Salvage blood samples had significantly higher intracellular components indicating active lysis: potassium (p = 0.019 and 8.2E-16), LDH (p = 3.3E-11 and 1.66E-6), and free-hemoglobin (p = 4.87E-7 and 0.001). The salvage blood mean hemolysis index (HI) was significantly higher than baseline (155x, p = 1.1E-10) and allogenic blood (7.23x, p = 2.29E-5).

CONCLUSIONS:
Intraoperative salvaged blood is composed of high proportions of irreversibly injured RBCs with HI even exceeding levels suitable for transfusion by US FDA and Council of Europe standards, properties that may decrease the suitability of salvaged RBCs as a blood replacement. Collection of postoperative laboratory data and perioperative outcomes are currently underway.
1074 A Prospective, Post Market, Multi-center, Open Label, Non-randomized Clinical Study of the Efficacy of Using a Cellular Bone Allograft (CBA) in Lumbar Fusion Surgery
Authors: Gunter Chris , Wind Joshua James 
Published: March 2024

INTRODUCTION:
Autologous bone grafting contains the osteoconductive, osteoinductive and osteogenic elements essential for bone healing in patients at a high-risk for nonunion. There is a lack of prospective lumbar fusion studies with comprehensive and objective outcome assessments that utilize alternatives to iliac crest bone grafting.

METHODS:
This analysis includes subjects with complete clinical and radiographic outcomes at 12-months (n = 221), and 24-months (n = 199) follow-up. Fusion was determined by independent review, characterizing motion (=3° and =3mm) from flexion/extension X-rays, AND the presence of bridging bone via CT.

RESULTS:
The mean age of the study cohort was 58.8 years with 63% being female, and a mean BMI of 30.7. Regarding the subjects reporting of risk-factors to bone healing (e.g., multilevel disease, BMI, nicotine use, diabetes), 86.5% of subjects reported at least a single risk factor, with 49% (n = 99) of subjects reporting multiple risk-factors to bone healing. Fusion success rates were 91.4% (202/221) at 12-months, and 91.9% (183/199) at 24-months. Patient reported outcomes included VAS Back and Leg Pain, ODI, and EQ-5D. Mean ODI significantly improved by 22.1 (p < 0.001) and 22.7 (p < 0.001) points from baseline at 12 and 24-months respectively. Back pain scores decreased significantly from baseline: 57.47 (28.62) to 18.46 (24.86) at 12 months, and 12.02 (21.01) at 24 months. VAS leg pain also significantly decreased from baseline to 12 and 24 months, with an overall decrease in mean score of 27.54 and 32.09 respectively.

CONCLUSIONS:
These study findings provide additional support for the viability and efficacy of CBAs in spinal fusion. The fusion rates observed in this study are comparable to ICBG fusion rates reported in the literature.
1077 Operative Management and Outcomes in Spinal Hemangioblastoma: A Multi-institutional Case Series of 59 Patients
Authors: Blitz Sarah , Friedman Gabriel , Coumans Jean-Valery , Chi John H. , Shin John H. , Curry William T. , Barker Fred , Chapman Paul H. , Chiocca E. Antonio , Borges Lawrence F. 
Published: March 2024

INTRODUCTION:
Hemangioblastoma is a rare benign neoplasm that accounts for 2-5% of all spinal cord tumors and is associated with von-Hippel Landau (VHL) disease in about 25-30% of patients. Symptomatic spinal hemangioblastomas are typically managed with en bloc microsurgical resection, but the infrequent nature of these lesions has limited the detailed characterization of reported management and surgical outcomes in the literature.

METHODS:
We retrospectively reviewed all patients with pathology-proven spinal hemangioblastoma. We collected information about demographics, preoperative symptoms and imaging, intraoperative characteristics, and postoperative course. We analyzed what variables influence postoperative changes in motor scores and McCormick scores.

RESULTS:
We included 59 patients (35 sporadic, 24 VHL). The average age of diagnosis was 48.7 (± 16.1) for sporadic tumors and 35.1 (± 12.6) for those associated with VHL (p = 0.001). Most tumors were cervical (46.6%) or thoracic (34.5%) and both intradural (93.2%) and intramedullary (71.2%). Most patients (69.5%) had multiple spinal tumors. The average lesion volume was 0.98 (± 1.1) cm3. The average symptom duration before surgery was 24.7 (± 73.2) months. Adjuvant therapies included radiation (6.8%) and chemotherapy (1.7%). At 1 month postoperatively, 4.4% had motor loss in any muscle group and 31.1% had motor gain, while 18.6% had a decreased McCormick score and 28.8% had an improved score at 1 month. While 72.9% of patients had numbness/paresthesia preoperatively, only 59.3% did at 1 month. Duration of pre-operative symptoms and time from diagnosis to surgery were not found to influence outcomes.

CONCLUSIONS:
Overall, surgical planning should be guided by symptom management. In this population, duration of preoperative symptoms and timing of surgery did not influence post-operative functional outcomes.
1226 Early Versus Delayed Fractionated Stereotactic Radiotherapy for Nonfunctioning Pituitary Adenoma
Authors: Sathe Anish , Siu Alan , Kang KiChang , Kayne Allison , Vinjamuri Shreya , Kelly Patrick David , Shi Wenyin , Evans James J. , Farrell Christopher James 
Published: March 2024

INTRODUCTION:
Stereotactic radiosurgery (SRS) can be used to treat residual or recurrent pituitary adenomas with good control rates. Fractionated stereotactic radiotherapy (FSRT) is a viable alternative with similar outcomes. It is currently unknown whether FSRT should be performed early for residual tumor or delayed until progression occurs.

METHODS:
A retrospective review of patients who underwent FSRT for a NFPA between January 2004 to December 2022 at a single institution was performed. We compared the endocrinologic, ophthalmologic, and radiographic outcomes in FSRT delivered as ADJ and PRG treatment.

RESULTS:
75 patients were analyzed, with a median follow-up of 53 months. FSRT was administered to 35 and 40 patients as ADJ and PRG, with a median time to treatment of 5.5 and 40 months, respectively. The tumor control rate was 94.3% for ADJ and 95.0% for PRG. Treatment resulted in four (11.4%) versus seven (17.5%) new endocrinopathies and two (5.7%) versus one (2.5%) new visual deficits for ADJ versus PRG. A survival analysis of time-to-new endocrinopathy showed no difference between the two cohorts. Median time from surgery to new endocrinopathy was 15.5 months for ADJ and 102.0 months for PRG (p = 0.02). The rate of new endocrinopathy at five years was 22.2% in for ADJ and 18.8% for PRG (p = 0.80).

CONCLUSIONS:
FSRT is effective in treating NFPA for residual and progressive tumors, with excellent tumor control rates comparable to SRS and a low risk of developing new endocrinopathies and visual deficits. The delayed treatment in the PRG cohort resulted in a greater duration until the development of a new endocrinopathy, suggesting that observation followed by FSRT on tumor progression may delay the onset of hypopituitarism while maintaining similar effectiveness in tumor control.
1247 Bridging the Gap: ALIF Outshines TLIF in Radiographic Reduction of L5-S1 Spondylolisthesis
Authors: Baig Ammad , Gassie Kelly , Monsour Molly , Carballo Cesar , Alayli Adam , Lockard Gavin , Gordon Jonah , Liaw Deborah , Pressman Elliot , Hidalgo Adolfo , Alikhani Puya 
Published: March 2024

INTRODUCTION:
Both the ALIF and TLIF are established surgical approaches for treating Grade 1 or 2 L5-S1 spondylolisthesis. Additionally, each procedure poses different complication profiles. There is a rising debate regarding ALIF versus TLIF regarding multiple outcomes including reduction of spondylolisthesis, thus, we aimed to compare our rates of radiographic reduction.

METHODS:
We conducted a retrospective review of isolated L5-S1 TLIF or ALIF surgeries at our tertiary care center from 2012-2022. These cases were reviewed for demographics, follow-up, preoperative parameters, surgical characteristics, postoperative parameters, radiographic outcomes, reduction rates and complications encountered. The inclusion criteria were minimum age of 18 years and a grade 1 or 2 spondylolisthesis at L5-S1 treated with ALIF or TLIF. We excluded patients with previous instrumentation, trauma, infection, and no spondylolisthesis.

RESULTS:
Of the 156 patients screened, 98 patients were specifically treated for this condition. The ALIF group (n = 40) had a higher rate of complete reduction of spondylolisthesis (90%) compared to the TLIF group (n = 58) (62.1%, p = 0.008). The TLIF group had a higher rate of partial reduction (84%, n = 21) compared to the ALIF group (16%, n = 4). Gender distribution differed significantly between the groups, with the ALIF group comprising 30% males and 70% females, while the TLIF group included 62.1% males and 37.9% females (p = 0.004). Baseline radiographic measures revealed a significant difference in Sagittal Vertical Axis (SVA), with the ALIF group exhibiting a lower average SVA (1.1 ± 3.3) compared to the TLIF group (4.3 ± 2.5, p = 0.005).

CONCLUSIONS:
Although further research is required, when discussing options with patients regarding surgical approaches for Grade 1-2 spondylolisthesis, ALIF demonstrates higher radiographic reduction rates than TLIF at L5-S1.
138 Inflammatory Neuropathy in the Military: Effects on Readiness and Retention
Authors: Scanlon Michaela Marie , Woodle Samuel , Puffer Ross 
Published: March 2024

INTRODUCTION:
Neuralgic amyotrophy (NA), or Parsonage-Turner Syndrome, is a complex, multifocal presumed inflammatory disorder of the peripheral nervous system. Presentation varies widely though it classically presents following a precipitating event and begins with a period of sudden onset pain followed by functional loss and atrophy. Prognosis is generally favorable with recovery rates near 80% by 2-3 years. Currently, no data exists on the natural history or surgical management of NA in the active duty (AD) military population, who are subject to uniquely physical work demands. As such, the impact of NA on military readiness and retention remains poorly understood.

METHODS:
AD service-members with a clinic ICD-10 diagnosis of NA were identified from the MHS medical record between the years 2011-2022 and data were obtained retrospectively through individual chart review.

RESULTS:
Over an eleven-year period, forty-one active duty patients were identified (27 males, 12 females, average age 39.6) with an ICD-10 diagnosis of NA. Average time to diagnosis from symptom presentation was 152 days (SD 177). Workup included EMG/NCS in nearly all patients, but advanced imaging in only 9/41 (22%). Ten patients underwent surgical intervention (7 nerve transfers, 1 neurolysis only, 1 tendon transfer, 1 cervical spine decompression). Full recovery was observed for 13/41 (32%) patients while 26/41 (63%) gained only partial improvement (two with unknown recovery/lost in follow-up). Only 1/10 (10%) surgical patients had full recovery. Eight patients underwent a medical board evaluation and were discharged from military service (20%).

CONCLUSIONS:
Neuralgic amyotrophy is a complex disease with a prolonged recovery course that can impact military readiness and active duty retainment.