bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordination Dependence of Magnetic Properties within a Family of Related [FeII2] Complexes of a Triazine‐Based Ligand (Eur. J. Inorg. Chem. 7/2006)
Authors: Quesada Manuel , de Hoog Paul , Gamez Patrick , Roubeau Olivier , Aromí Guillem , Donnadieu Bruno , Massera Chiara , Lutz Martin , Spek Anthony L. , Reedijk Jan 
Published: March 2006

AbstractThe cover picture shows the crystal structures of three related iron(II) complexes obtained with a triazine‐based polypyridyl ligand, where minor structural changes result in very disparate magnetic properties, ranging from antiferromagnetic exchange through spin crossover to ferromagnetic coupling. These are clearly illustrated by the characteristic plots of the corresponding magnetic behaviours. The background map of Europe symbolizes the European collaboration responsible for the studies reported by P. Gamez, O. Roubeau, et al. on p. 1353 ff.
Antioxidative effect of the main sinapic acid derivatives from rapeseed and mustard oil by‐products
Authors: Thiyam Usha , Stöckmann Heiko , Zum Felde Thomas , Schwarz Karin 
Published: March 2006

AbstractAmongst oilseeds, rapeseed and mustard are rich sources of phenolic compounds, which also prominent in the by‐products of their respective oil processing or in commercial rapeseed and mustard press cakes. These cakes are rich sources of sinapic acid derivatives, which could be extracted as free sinapic acid or sinapine, the choline ester of sinapic acid. Sinapic acid is a widely investigated antioxidative compound. However, the main compound in the press cakes is present as sinapine. Investigations on the free‐radical‐scavenging activity of sinapic acid and sinapine indicate that sinapine had a significant but lower activity as compared to sinapic acid. Apart from this, sinapic acid, sinapine and different tocopherols were compared as antioxidants for inhibition of the formation of lipid oxidation products in purified rapeseed oils. The oxidation at 40 °C was monitored by the formation of hydroperoxides and propanal. The experiments indicate that in contrast to tocopherol mixtures addition of sinapic acid causes increasing inhibition of hydroperoxide formation when enhancing the concentration from 50 to 500 μmol/kg oil. Sinapine was not able to inhibit the formation of hydroperoxides, compared to sinapic acid. This indicates that sinapic acid‐rich extracts, as compared to sinapine‐rich fractions, could better inhibit the lipid oxidation in bulk lipid systems.
Effect of the full refining process on rice bran oil composition and its heat stability
Authors: Mezouari Samia , Eichner Karl , Kochhar S. Parkash , Brühl Ludger , Schwarz Karin 
Published: March 2006

AbstractThe effects of the chemical refining process on the minor compounds of rice bran oil and its heat stability were investigated. After 8 h of heating, about 50% and 30% of total tocopherols remained in crude and refined rice bran oil, respectively. The individual tocopherols were differently affected by the refining process. The order of heat stability of tocopherols and tocotrienols in crude oil was found to be different from that in fully refined oil. A similar tendency was observed for sterols. After 8 h of heating, 65% and 72% of total sterols, and 14% and 46% of sterol esters, of crude or fully refined rice bran oil, respectively, disappeared. The heating process led to a 4% and 10.3% increase in polymer contents in crude and refined rice bran oil, respectively. Although refined rice bran oil showed good heat stability, when compared to crude oil its heat stability was decreased to some extent.
Reactions of N‐, S‐ and O‐Nucleophiles with 3,4,6‐Tri‐O‐benzyl‐D‐glucal Mediated by Triphenylphosphane Hydrobromide versus Those with HY Zeolite
Authors: Rauter Amélia P. , Almeida Tânia , Vicente Ana I. , Ribeiro Verónica , Bordado João C. , Marques João P. , Ramôa Ribeiro Fernando , Ferreira Maria J. , Oliveira Conceição , Guisnet Michel 
Published: March 2006

AbstractDirect C–N bond formation has been accomplished by reaction of 1,5‐anhydro‐3,4,6‐tri‐O‐benzyl‐2‐deoxy‐D‐arabino‐hex‐1‐enitol (3,4,6‐tri‐O‐benzyl‐D‐glucal) with N‐nucleophiles, using triphenylphosphane hydrobromide as catalyst in dichloromethane or THF. 2‐Deoxy‐S‐ and ‐O‐glycosides have also been prepared with thiols, sterols, flavonoids, alcohols and sugars as nucleophiles, with α‐stereoselectivity. Sterically demanding reagents such as sterols, flavonoids, sugars and an indole give only the α‐anomer in dichloromethane, while the purine nucleosides in THF were obtained as anomeric mixtures whilst maintaining the α‐stereoselectivity. This procedure has led to an easy and straightforward synthesis of a variety of biomolecules, in moderate to high yield, with the first use of triphenylphosphane hydrobromide for N‐ and S‐glycosylation. An alternative method for C–O and C–S bond formation uses HY zeolite to promote theFerrier rearrangement of 3,4,6‐tri‐O‐benzyl‐D‐glucal to give exclusively the corresponding 2,3‐unsaturated α‐O‐ and α‐S‐glycosides in moderate yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
A numerical approach for groundwater flow in unsaturated porous media
Authors: Quintana F. , Guarracino L. , Saliba R. 
Published: March 2006

AbstractIn this article, a computational tool to simulate groundwater flow in variably saturated non‐deformable fractured porous media is presented, which includes a conceptual model to obtain analytical expressions of water retention and hydraulic conductivity curves for fractured hard rocks and a numerical algorithm to solve the Richards equation. To calculate effective saturation and relative hydraulic conductivity curves we adopt the Brooks–Corey model assuming fractal laws for both aperture and number of fractures. A standard Galerkin formulation was employed to solve the Richards' equation together with a Crank–Nicholson scheme with Richardson extrapolation for the time discretization.The main contribution of this paper is to group an analytical model of the authors with a robust numerical algorithm designed to solve adequately the highly non‐linear Richards' equation generating a tool for porous media engineering. Copyright © 2006 John Wiley & Sons, Ltd.
Near‐tetraploidy in childhood B‐cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1‐positive leukemic cases
Authors: Attarbaschi Andishe , Mann Georg , König Margit , Steiner Manuel , Dworzak Michael N. , Gadner Helmut , Haas Oskar A. 
Published: March 2006

AbstractNear‐tetraploidy (82–94 chromosomes) makes up fewer than 1% of childhood acute lymphoblastic leukemia (ALL) cases and has been reportedly associated with a possibly poorer prognosis compared with other ploidy groups. We analyzed 783 patients enrolled in the ALL‐BFM‐Austria 86, ‐90, ‐95, ‐99/2000 and Interfant‐Austria 99 trials in order to assess its incidence, biological characteristics, and prognostic relevance. Twelve of 783 patients (1.5%) had a near‐tetraploid ALL. Fluorescence in situ hybridization revealed that eight of the nine B‐cell precursor (BCP) cases and none of the three T‐cell ALL cases had an ETV6/RUNX1 rearrangement. After a median follow‐up of 11.4 years, none of the patients has relapsed or died. Thus, near‐tetraploidy appears to be a specific feature of ETV6/RUNX1+ BCP ALL cases that in turn may explain its excellent outcome. © 2006 Wiley‐Liss, Inc.
Detectability assessment of interannual variations in terrestrial water storage from satellite gravimetry using an offline land surface model simulation
Authors: Nakaegawa Tosiyuki 
Published: March 2006

AbstractThe detectability of the interannual variations of terrestrial water storage in 70 river basins acquired by satellite gravimetry was investigated using the Japan Meteorological Agency–Simple Biosphere (JMA–SiB) model. Terrestrial water storages for the monthly, seasonal, and annual averaging periods were computed from the output of a 10 year integration performed by the JMA‐SiB model. The satellite specification was assumed to be the same as for the NASA Gravity Recovery and Climate Experiment (GRACE). The total errors in the satellite‐gravimetry‐derived terrestrial water storage (including the instrument error, atmospheric error, and error due to the postglacial rebound) were computed for each period at each basin. The standard deviation of the interannual variation with the total error for three different time scales, averaging monthly, seasonal and annual results, was compared precisely in the continental‐scale river basins. The error‐signal ratio (i.e. the ratio of the total error to the standard deviation) was used to assess the detectability. The results demonstrate that the gravity satellite missions can detect the interannual variations in large river basins in most years, but the gravity satellite missions can detect those in small river basins only with the probability of 1 year out of 3 years or more. These characteristics were found in all the three averaging time scales. Copyright © 2006 John Wiley & Sons, Ltd.
Tumor suppressive activity of a variant isoform of manganese superoxide dismutase released by a human liposarcoma cell line
Authors: Mancini Aldo , Borrelli Antonella , Schiattarella Antonella , Fasano Stefania , Occhiello Antonella , Pica Alessandra , Sehr Peter , Tommasino Massimo , Nüesch Jürg P.F. , Rommelaere Jean 
Published: March 2006

AbstractA cell line derived from a pleiomorphic liposarcoma, named LSA, was previously reported to secrete (a) factor(s) exhibiting oncotoxic properties. The present article describes the isolation, purification and sequence analysis of a protein released by LSA cells into conditioned culture medium. This protein proved to be a variant isoform of manganese superoxide dismutase (MnSOD), hence its designation as LSA‐type‐MnSOD. This LSA‐type‐SOD differed from conventional SODs in its secretion by producer cells, contrasting with the normal localization of SODs in the mitochondrial matrix. Interestingly, during the protein purification process, LSA‐type‐SOD cosegregated with a cytotoxic activity directed against a number of tumor cell lines, as determined under in vitro conditions. This cytopathic effect was most likely due to LSA‐type‐SOD, since it could be fully reproduced using recombinant SOD that was expressed from cDNA clones isolated from LSA cells mRNA preparations and henceforth designated L‐rSOD. In addition to its manifestation in cell lines kept in tissue culture, the oncotoxicity of LSA‐type‐SOD was further reflected in a remarkable capacity of this protein for suppression of mammary tumors in Balb‐C‐FRIII mice. Animals subcutaneously injected with L‐rSOD in the tumor area showed a complete disruption of established mammary carcinomas, as monitored by nuclear magnetic resonance (NMR) scanning. Moreover, metastatic spreading, which was readily detected in the control group, was suppressed in the treated animals. Altogether these data suggest that LSA‐type‐SOD interferes with survival and spreading of neoplastically transformed cells and deserves to be future validated as a therapeutic agent against cancer, either alone or in combination with conventional treatments. © 2006 Wiley‐Liss, Inc.
Trends in survival and excess risk of death after diagnosis of cancerin 1980–1996 in New South Wales, Australia
Authors: Yu Xue Q. , O'Connell Dianne L. , Gibberd Robert W. , Coates Alan S. , Armstrong Bruce K. 
Published: March 2006

AbstractSurvival from almost all cancers has improved during the last 30 years. There is debate over the reasons for the improvement. We examined trends in survival for 28 cancers from 1980 to 1996 in New South Wales (NSW), Australia, with adjustment for disease spread at diagnosis. NSW Central Cancer Registry data were used to estimate 5‐year relative survival and relative excess risk of death for patients diagnosed in 1980–84, 1985–88, 1989–92 and 1993–96. Statistical significance of variation in excess deaths between periods of diagnosis was assessed using Poisson regression, with adjustment for age, sex, duration of follow‐up, histology and spread of disease at diagnosis. There were statistically significant falls in excess deaths for 20 of the cancers with a 25% fall for all cancers combined. Cancers of the prostate, liver, thyroid, breast, gallbladder, body of uterus, rectum, cervix and ovary had falls of >30%. The falls varied by spread of disease; the largest being in localised and regionally spread tumours. Overall survival, when unadjusted for spread of cancer, generally fell in parallel with that in the specific categories of spread, which implies that stage migration did not contribute importantly to survival trends. While acknowledging the limitations of incomplete data on stage of cancer at diagnosis, we conclude that falls in excess deaths in NSW from 1980 to 1996 are unlikely, for many cancers, to be attributed to earlier diagnosis or stage migration; thus advances in cancer treatment have almost certainly contributed to them. © 2006 Wiley‐Liss, Inc.
Cathepsin S expression: An independent prognostic factor in glioblastoma tumours—a pilot study
Authors: Flannery Thomas , McQuaid Stephen , McGoohan Caroline , McConnell Robert S. , McGregor Gordon , Mirakhur Meenakshi , Hamilton Peter , Diamond James , Cran Gordon , Walker Brian , Scott Christopher , Martin Lorraine , Ellison David , Patel Chirag , Nicholson Clare , Mendelow David , McCormick Derek , Johnston Patrick G. 
Published: March 2006

AbstractCysteine proteinases have been implicated in astrocytoma invasion. We recently demonstrated that cathepsin S (CatS) expression is up‐regulated in astrocytomas and provided evidence for a potential role in astrocytoma invasion (Flannery et al., Am J Path 2003;163(1):175–82). We aimed to evaluate the significance of CatS in human astrocytoma progression and as a prognostic marker. Frozen tissue homogenates from 71 patients with astrocytomas and 3 normal brain specimens were subjected to ELISA analyses. Immunohistochemical analysis of CatS expression was performed on 126 paraffin‐embedded tumour samples. Fifty‐one astrocytoma cases were suitable for both frozen tissue and paraffin tissue analysis. ELISA revealed minimal expression of CatS in normal brain homogenates. CatS expression was increased in grade IV tumours whereas astrocytoma grades I–III exhibited lower values. Immunohistochemical analysis revealed a similar pattern of expression. Moreover, high‐CatS immunohistochemical scores in glioblastomas were associated with significantly shorter survival (10 vs. 5 months, p = 0.014). With forced inclusion of patient age, radiation dose and Karnofsky score in the Cox multivariate model, CatS score was found to be an independent predictor of survival. CatS expression in astrocytomas is associated with tumour progression and poor outcome in glioblastomas. CatS may serve as a useful prognostic indicator and potential target for anti‐invasive therapy. © 2006 Wiley‐Liss, Inc.
Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women
Authors: Larsson Susanna C. , Bergkvist Leif , Wolk Alicja 
Published: March 2006

AbstractProcessed meat consumption has been associated with an increased risk of stomach cancer in some epidemiological studies (mainly case–control). Nitrosamines may be responsible for this association, but few studies have directly examined nitrosamine intake in relation to stomach cancer risk. We prospectively investigated the associations between intakes of processed meat, other meats and N‐nitrosodimethylamine (the most frequently occurring nitrosamine in foods) with risk of stomach cancer among 61,433 women who were enrolled in the population‐based Swedish Mammography Cohort. Information on diet was collected at baseline (between 1987 and 1990) and updated in 1997. During 18 years of follow‐up, 156 incident cases of stomach cancer were ascertained. High consumption of processed meat, but not of other meats (i.e., red meat, fish and poultry), was associated with a statistically significant increased risk of stomach cancer. After adjustment for potential confounders, the hazard ratios for the highest compared with the lowest category of intake were 1.66 (95% CI = 1.13–2.45) for all processed meats, 1.55 (95% CI = 1.00–2.41) for bacon or side pork, 1.50 (95% CI = 0.93–2.41) for sausage or hotdogs and 1.48 (95% CI= 0.99–2.22) for ham or salami. Stomach cancer risk was 2‐fold higher among women in the top quintile of N‐nitrosodimethylamine intake when compared with those in the bottom quintile (hazard ratio = 1.96; 95% CI = 1.08–3.58). Our findings suggest that high consumption of processed meat may increase the risk of stomach cancer. Dietary nitrosamines might be responsible for the positive association. © 2006 Wiley‐Liss, Inc.
24,25‐dihydroxyvitamin D3 binds to catalase
Authors: Larsson Dennis , Anderson Deryk , Smith Nathan M. , Nemere Ilka 
Published: March 2006

AbstractThere is increasing evidence that the vitamin D metabolite, 24,25‐dihydroxyvitamin D3 (24,25(OH)2D3) has endocrine actions. In the current work, we report that an endogenous binding protein for 24,25(OH)2D3 is catalase, based on sequence analysis of the isolated protein. An antibody (Ab 365) generated against equivalent protein recognized bovine catalase and a 64 kDa band in subcellular fractions of chick intestine. A commercially available anti‐catalase antibody reduced specific [3H]24,25(OH)2D3 binding in subcellular fractions of chick intestine by greater than 65%, relative to the same fractions treated with an unrelated antibody (Ab 099). The same commercially available anti‐catalase was able to block the inhibitory actions of 24,25(OH)2D3 on 32P uptake in isolated intestinal epithelial cell suspensions. We subsequently characterized binding of steroid to commercially available catalase, and found that between 0 and 5 nM of enzyme added to subcellular fraction P2 (20,000g, 10‐min post‐nuclear pellet) resulted in a linear increase in the amount of [3H]24,25(OH)2D3 specifically bound. Additional studies indicated that 25(OH)D3 was an effective competitor for binding, whereas 1,25(OH)2D3 only poorly displaced [3H]24,25(OH)2D3. Saturation analyses with added catalase yielded a physiologically relevant affinity constant (KD = 5.6 ± 2.7 nM) and a Bmax = 209 ± 34 fmols/mg protein, comparable to previous studies using purified basal lateral membranes or vesicular fractions. Moreover, in a study on subcellular fractions isolated from chickens of varying ages, we found that in females, both specific [3H]24,25(OH)2D3 binding and catalase activity increased from 7‐ to 58‐week‐old birds, whereas in males, elevated levels of both parameters were expressed in preparations of 7‐ and 58‐week‐old birds. The data suggest that signal transduction may occur through modulation of hydrogen peroxide production. J. Cell. Biochem. 97: 1259–1266, 2006. © 2005 Wiley‐Liss, Inc.
Positive correlation between the expression of X‐chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer
Authors: Martínez‐Arribas Fernando , Agudo David , Pollán Marina , Gómez‐Esquer Francisco , Díaz‐Gil Gema , Lucas Raul , Schneider José 
Published: March 2006

AbstractIn a recent report, it has been postulated that the ubiquitous RBM proteins might constitute a novel family of apoptosis modulators. We measured the expression of the X‐chromosome RBM genes (RBMX, RBM3, and RBM10) in 122 breast cancers by means of differential RT‐PCR. Using the same method, we also studied the expression of the apoptosis‐related genes Bcl‐2 and Bax. Markers of hormone dependence (estrogen and progesterone receptors), proliferation (Ki67 and DNA‐ploidy), angiogenesis (VEGF and CD105), as well as oncogene (c‐erb‐B2), and tumor suppressor gene (p53) expression were also analyzed. The expression of all X‐chromosome RBM genes was significantly associated with the expression of the proapoptotic Bax gene (RBMX, P = 0.039; RBM3, P < 0.001; RBM10 large variant, P < 0.001; RBM10 small variant, P < 0.001). Furthermore, the expression of both RBM10 variants was significantly associated with the expression of the VEGF gene (large variant, P = 0.004; small variant, P = 0.003). We also found an association of borderline significance (P = 0.05) between the expression of RBM3, the large variant of RBM10 and wild‐type p53. Expression of the small RBM10 variant, finally, was associated with high proliferation of the tumors (Ki67 ≥ 20%; P = 0.037). The expression of both RBM10 variants seems to be interdependent to a significant degree (r = 0.26, P = 0.006). From these results, it seems that the X‐chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. J. Cell. Biochem. 97: 1275–1282, 2006. © 2005 Wiley‐Liss, Inc.
Cellular and molecular mechanisms of nicotine's pro‐angiogenesis activity and its potential impact on cancer
Authors: Mousa Sarah , Mousa Shaker A. 
Published: March 2006

AbstractThe present study examined the mechanisms of nicotine's effect on angiogenesis and its impact on tumor growth. Nicotine demonstrated significant (P < 0.01) stimulation of the release of endothelial cell growth factor, basic fibroblast growth factor (b‐FGF) but not vascular endothelial growth factor (VEGF). In a concentration‐dependent manner, nicotine induced endothelial cell tube formation. Additionally, in the chick chorioallantoic membrane (CAM) model of angiogenesis, nicotine effectively induced the generation of new blood vessels (P < 0.01), an effect that is mediated via b‐FGF. The pro‐angiogenesis effect of nicotine in the CAM model was maximally blocked by either anti‐integrin αvβ3or inhibitor of mitogen activated protein kinase (MAPK, ERK 1/2). In the CAM tumor implant model, nicotine doubled (P < 0.01) the growth rate of breast, colon, and lung cancer. These data indicated that the pro‐angiogenesis effect is mediated via b‐FGF and induced through the nicotinic receptor, αvβ3integrin, and MAPK. J. Cell. Biochem. 97: 1370–1378, 2006. © 2005 Wiley‐Liss, Inc.
Paxillin modulates squamous cancer cell adhesion and is important in pressure‐augmented adhesion
Authors: Conway William C. , Van der Voort van Zyp Jochem , Thamilselvan Vijayalakshmi , Walsh Mary F. , Crowe David L. , Basson Marc D. 
Published: March 2006

AbstractPaxillin is an adapter protein regulating signaling and focal adhesion assembly that has been linked to malignant potential in many malignancies. Overexpression of paxillin has been noted in aggressive tumors. Integrin‐mediated binding through the focal adhesion complex is important in metastatic adhesion and is upregulated by extracellular pressure in malignant colonocytes through FAK and Src activation. Neither head and neck cancers nor paxillin have been studied in this regard. We hypothesized that paxillin would play a role in modulating squamous cancer adhesion both at baseline and under conditions of increased extracellular pressure. Using SCC25 tongue squamous cancer cells stably transfected with either an empty selection vector or paxillin expression and selection vectors, we studied adhesion to collagen, paxillin, FAK, and Src expression and phosphorylation in cells maintained for 30 min under ambient or 15 mmHg increased pressure conditions. Paxillin‐overexpressing cells exhibited adhesion 121 ± 2.9% of that observed in vector‐only cells (n = 6, P < 0.001) under ambient pressure. Paxillin‐overexpression reduced FAK phosphorylation. Pressure stimulated adhesion to 118 ± 2.3% (n = 6, P < 0.001) of baseline in vector‐only cells, similar to its effect in the parental line, and induced paxillin, FAK, and Src phosphorylation. However, increased pressure did not stimulate adhesion or phosphorylate paxillin, FAK, or Src further in paxillin‐overexpressing cells. Metastasizing squamous cancer cell adhesiveness may be increased by paxillin‐overexpression or by paxillin activation by extracellular pressure during surgical manipulation or growth within a constraining compartment. Targeting paxillin in patients with malignancy and minimal tumor manipulation during surgical resection may be important therapeutic adjuncts. J. Cell. Biochem. © 2006 Wiley‐Liss, Inc.