bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methylomes as key features for predicting recombination in some plant species
Authors: Peñuela Mauricio , Finke Jorge , Rocha Camilo 
Published: March 2024

AbstractKnowing how chromosome recombination works is essential for plant breeding. It enables the design of crosses between different varieties to combine desirable traits and create new ones. This is because the meiotic crossovers between homologous chromatids are not purely random, and various strategies have been developed to describe and predict such exchange events. Recent studies have used methylation data to predict chromosomal recombination in rice using machine learning models. This approach proved successful due to the presence of a positive correlation between the CHH context cytosine methylation and recombination rates in rice chromosomes. This paper assesses the question if methylation can be used to predict recombination in four plant species: Arabidopsis, maize, sorghum, and tomato. The results indicate a positive association between CHH context methylation and recombination rates in certain plant species, with varying degrees of strength in their relationships. The CG and CHG methylation contexts show negative correlation with recombination. Methylation data was key effectively in predicting recombination in sorghum and tomato, with a mean determination coefficient of 0.65 ± 0.11 and 0.76 ± 0.05, respectively. In addition, the mean correlation values between predicted and experimental recombination rates were 0.83 ± 0.06 for sorghum and 0.90 ± 0.05 for tomato, confirming the significance of methylomes in both monocotyledonous and dicotyledonous species. The predictions for Arabidopsis and maize were not as accurate, likely due to the comparatively weaker relationships between methylation contexts and recombination, in contrast to sorghum and tomato, where stronger associations were observed. To enhance the accuracy of predictions, further evaluations using data sets closely related to each other might prove beneficial. In general, this methylome-based method holds great potential as a reliable strategy for predicting recombination rates in various plant species, offering valuable insights to breeders in their quest to develop novel and improved varieties.
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
Authors: Yilmaz Esen , Acar Gozde , Onal Ummugulsum , Erdogan Ender , Baltaci Abdulkerim Kasim , Mogulkoc Rasim 
Published: March 2024

AbstractBackground: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors living with serious neurological sequelae; thus, it has recently attracted a lot of attention in the field of medical study. Purpose: The aim of this study was to determine the effect of naringin supplementation on neurogenesis and brain-derived neurotrophic factor (BDNF) levels in the brain in experimental brain ischemia–reperfusion. Study design: The research was carried out on 40 male Wistar-type rats (10–12 weeks old) obtained from the Experimental Animals Research and Application Center of Selçuk University. Experimental groups were as follows: (1) Control group, (2) Sham group, (3) Brain ischemia–reperfusion group, (4) Brain ischemia–reperfusion + vehicle group (administered for 14 days), and (5) Brain ischemia–reperfusion + Naringin group (100 mg/kg/day administered for 14 days). Methods: In the ischemia–reperfusion groups, global ischemia was performed in the brain by ligation of the right and left carotid arteries for 30 min. Naringin was administered to experimental animals by intragastric route for 14 days following reperfusion. The training phase of the rotarod test was started 4 days before ischemia–reperfusion, and the test phase together with neurological scoring was performed the day before and 1, 7, and 14 days after the operation. At the end of the experiment, animals were sacrificed, and then hippocampus and frontal cortex tissues were taken from the brain. Double cortin marker (DCX), neuronal nuclear antigen marker (NeuN), and BDNF were evaluated in hippocampus and frontal cortex tissues by Real-Time qPCR analysis and immunohistochemistry methods. Results: While ischemia–reperfusion increased the neurological score values, DCX, NeuN, and BDNF levels decreased significantly after ischemia in the hippocampus and frontal cortex tissues. However, naringin supplementation restored the deterioration to a certain extent. Conclusion: The results of the study show that 2 weeks of naringin supplementation may have protective effects on impaired neurogenesis and BDNF levels after brain ischemia and reperfusion in rats.
Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan
Authors: Usuki Kensuke , Kameda Takuro , Kawano Noriaki , Ito Tomoki , Hashimoto Yoshinori , Shide Kotaro , Kawano Hiroshi , Sekine Masaaki , Toyama Takanori , Iizuka Hiromitsu , Sato Seiichi , Takeuchi Masanori , Ishizaki Junzo , Maeda Kouichi , Nakai Michikazu , Yamashita Kiyoshi , Kubuki Yoko , Shimoda Kazuya 
Published: March 2024

AbstractMyeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or insertions of 8p11.2 were detected. Among the 10 patients with 8p11.2 translocations, three patients were diagnosed with MLN-FGFR1 abnormalities, which were confirmed by FISH analysis. Peripheral blood eosinophilia was observed in all three patients, and all progressed to AML or T-lymphoblastic lymphoma/leukemia. The prevalence of 8p11.2 translocations in clinical practice and the proportion of MLN-FGFR1 abnormalities in patients with 8p11.2 translocations in Japan were consistent with those in previous reports from Western countries.
Zinc oxide@citric acid-modified graphitic carbon nitride nanocomposites for adsorption and photocatalytic degradation of perfluorooctanoic acid
Authors: Navidpour Amir Hossein , Safaei Javad , Johir Md Abu Hasan , Ni Bing-Jie , Dashti Amir , Li Xiaowei , Zhou John L. 
Published: March 2024

AbstractPerfluorooctanoic acid (PFOA) is a highly persistent organic pollutant of global concern. A novel nanocomposite composed of ZnO nanoparticles and citric acid-modified g-C3N4 was synthesized by ball milling process. The synthesized nanocomposite was more efficient than pure ball-milled ZnO nanoparticles for PFOA elimination under visible light irradiation. The optimal hybrid photocatalyst, produced by the addition of 5 wt% of citric acid-modified g-C3N4, demonstrated significantly better performance for PFOA removal than pure ZnO nanoparticles under UV irradiation, with the apparent rate constants of 0.468 h−1 and 0.097 h−1, respectively. The addition of peroxymonosulfate (0.53 g L−1) significantly increased PFOA removal, clarifying the crucial effect of sulfate radicals on PFOA photodegradation. In comparison, citric acid-modified g-C3N4 was not effective for PFOA elimination under visible light irradiation, even with the addition of peroxymonosulfate. Further experiments under dark conditions identified surface adsorption on hybrid photocatalyst as a key process in total PFOA removal. In summary, PFOA removal by ZnO@citric acid-modified graphitic carbon nitride nanocomposites is due to the combined action from adsorption and photodegradation, with adsorption as the dominating mechanism.
Sustainability implications of lateral wander modes for autonomous trucks
Authors: Fahad Mohammad , Koren Csaba , Nagy Richard 
Published: March 2024

AbstractAutonomous trucks can bring changes in transport infrastructure in terms of sustainability based on the type of lateral wander mode used. In this research, two lateral wander modes, a zero wander and uniform wander mode are analyzed based on their applicability for sustainability by analyzing the CO2 emissions occurred during pavements life cycle. Both lateral wander modes have been analyzed in terms of occurrence of fatigue damage by using finite element analysis in ABAQUS. The fatigue damage predictions have then been used for planning the maintenance interventions for both lateral wander modes. Life cycle analysis has been performed for the analysis period of 30 years for the pavement section of 10 km. Results show that zero wander mode generates more emissions as a result of premature fatigue damage under channelized loading. The uniform wander mode leads to 20% less emissions when compared to zero wander mode. Moreover, the use of full depth reclamation during pavement’s life cycle improves the CO2 emissions by 15% when compared to traditional removal and reconstruction methods. Therefore, the uniform wander mode is favorable for improvement of pavement sustainability in terms of CO2 emissions.
Antibacterial activity of extracellular biosynthesized iron oxide nanoparticles against locally isolated β-lactamase-producing Escherichia coli from Egypt
Authors: Abou-Dobara Mohamed I. , Kamel May A. , El-Sayed Ahmed K. A. , El-Zahed Mohamed M. 
Published: March 2024

AbstractNowadays, extended spectrum β-lactamase (ESBL) producing Escherichia coli has been recognized and recorded worldwide as one of the main causing agents and a major contributor to nosocomial infections. The current study aimed to isolate and detect β-lactamase-producing E. coli and use it in the extracellular biosynthesis of iron oxide nanoparticles (Fe2O3 NPs). Fifteen Gram-negative (G-ve), lactose-fermenting, negative citrate and non-spore-forming coliform bacteria were isolated from the total bacterial isolates from water samples. Different tests were performed to detect β-lactamase-producing E. coli isolates including the chromogenic methods as acidimetric and iodometric techniques and the phenotypic methods as cloverleaf test and Masuda double-disc test. ESBL-producing E. coli was detected and confirmed by a modified double disc synergy test using ceftazidime, cefotaxime, ceftriaxone, amoxicillin combined with clavulanic acid, imipenem, cefepime, and cefoxitin. The quantitative assay of β-lactamase was done using a micro-iodometric assay. Among E. coli bacterial isolates, S1B1 isolate (the highest isolate of β-lactamase activity) was selected and tested for the extracellular biosynthesis of Fe2O3 NPs. The produced nanoparticles (NPs) were characterized by UV–visible spectroscopy, X-ray diffraction analysis, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscope and Zeta analysis. Results confirmed the successful biosynthesis of Fe2O3 NPs which displayed an absorption peak at 346 nm and a Fe2O3 crystallographic lattice plane at (104). Fe2O3 NPs were negatively charged spherical-shaped NPs with an average size of ≈ 24 ± 2 nm. The FTIR spectrum refers to the presence of NPs-associated proteins which act as stabilizing and capping agents. Antibacterial activity of Fe2O3 NPs was tested against Staphylococcus aureus ATCC25923, Bacillus cereus ATCC6633 (G+ve bacterium), Pseudomonas aeruginosa ATCC27853 (G-ve bacterium), as well as the β-lactamase-producing E. coli S1B1 strain. Fe2O3 NPs revealed moderate to strong antibacterial action against the tested strains with a minimum inhibition concentration (MIC) ranging from 25 to 40 µg/ml.
Lignin-impregnated biochar assisted with microwave irradiation for CO2 capture: adsorption performance and mechanism
Authors: Zhang Xueyang , Xu Haoliang , Xiang Wei , You Xinxiu , Dai Huantao , Gao Bin 
Published: March 2024

AbstractBamboo biochar was modified by lignin impregnation and microwave irradiation to enhance its performance for CO2 capture. The pore structure of lignin-impregnated biochar was significantly affected by the impregnation ratio. The maximum specific surface area of 377.32 m2 g−1 and micropore volume of 0.163 cm3 g−1 were observed on the biochar with an impregnation ratio of 1:20 (mass ratio of lignin to biochar). Lignin impregnation increased the CO2 adsorption capacity of biochar up to 134.46 mg g−1. Correlation analysis confirmed the crucial role of biochar’s pore structure in adsorption. The Avrami model fitted the CO2 capture curves well. The calculation of adsorption activation energy suggested that the adsorption process was dominated by physical mechanism assisted with partial chemical mechanism. Meanwhile, Langmuir isotherm analysis indicated that lignin impregnation transformed the larger pores of biochar into more uniform micropores, thereby making the adsorption process closer to monolayer adsorption. Both the high reusability (89.79–99.06%) after 10 successive cycles and the excellent CO2 selectivity in competitive adsorption confirmed that lignin-impregnated biochar is an outstanding adsorbent for CO2 capture.
Graphical Abstract
Exercise Interventions for the Prevention and Treatment of Anthracycline-Induced Cardiotoxicity in Women with Breast Cancer: A Systematic Review
Authors: Li Hongmei , Liu Haiyun , Wang Boliang , Jia Xiao , Yu Jingjing , Zhang Yurong , Sang Die , Zhang Yimin 
Published: March 2024

Abstract

Purpose
Anthracyclines have been one of the standard therapies for breast cancer (BC), and dose-related cardiotoxicity is one serious side effect. Exercise is an effective strategy for the prevention and management of BC, endorsed by experts in both exercise and oncology. However, there is a great deal of confusion about the effectiveness of exercise on anthracycline-induced cardiotoxicity and the exercise prescription (i.e., timing, type, and intensity) for cardiotoxicity, which limits its application in clinical settings. The aim of this article is to review the safety of exercise in BC patients receiving anthracyclines and its effectiveness in preventing cardiotoxicity.

Methods
Six electronic databases were searched using terms related to exercise, BC, anthracyclines, and cardiotoxicity for retrieving clinical randomized controlled trials in either Chinese or English. A summary of the included literature was also provided.

Results
Of 202 records screened, 10 were eligible. A total of 434 BC patients (stage I–IIIC, mean age ranged from 43.5 to 52.4 years) were included. The main findings were that: (1) Acute (a single bout) moderate-to-vigorous aerobic exercise could prevent NT-proBNP elevation beyond the threshold of acute myocardial injury; (2) Long-term (> 8 weeks) moderate-to-high intensity aerobic exercise (continuous or interval) could improve or maintain left ventricular ejection fraction and cardiorespiratory fitness in BC patients. However, the optimal timing, type, and intensity of exercise for people with BC to prevent cardiotoxicity remain unclear.

Conclusion
Moderate-to-vigorous intensity exercise may be an effective non-pharmacological approach to mitigate cardiotoxicities induced by anthracyclines in women with BC. However, the optimal exercise prescription for preventing cardiotoxicity remains unclear.
Designing sensory adaptive environments to enhance participation in healthcare for autistic children
Authors: Rios-Vega Lady , Carroll Amy , Dumont Rachel , Treadwell-Deering Diane , Fields Matthew , Schaaf Roseann 
Published: March 2024

Abstract
Purpose
Many autistic individuals experience sensory features that impact participation in healthcare. In this study, we aimed to identify the needs of autistic children during healthcare participation and, based on the findings, generate solutions to improve participation in healthcare.

Methods
A design-thinking approach with qualitative methods was used. First, observation of the environment and journey mapping were completed as part of the empathy stage of design thinking. Next, six parents of autistic children completed semi-structured interviews. The interviews were transcribed, and thematic analysis was used to identify themes. Next, healthcare providers participated in a group session to discuss experiences caring for autistic children. These data were also analyzed using qualitative methods, and themes emerged. Finally, healthcare providers and five interior design and architecture professionals reviewed the themes from both groups and the best available literature. They participated in a brainstorming session where solutions were collaboratively generated.

Results
Four main themes emerged from the parent's interviews, and three themes emerged from the healthcare provider’s input. Several solutions were identified during the brainstorming session, including a prototype for a sensory adaptive environment, sensory adaptations during medical procedures, and training for providers on sensory features in autism.

Conclusion
The design thinking method was appropriate to identify the problem and potential solutions to improve participation in healthcare for autistic children.
Performance of inert particles as lubricant additives compared to fully formulated industrial forming oils in sheet metal forming
Authors: Arinbjarnar Úlfar , Moghadam Marcel , Nielsen Chris Valentin 
Published: March 2024

AbstractThe increasingly restrictive legislation on the use of hazardous chemicals in lubricant formulation necessitates the use of less hazardous lubricant additives in the sheet metal forming industry. The tribological performance of calcium carbonate (CaCO3) as a green lubricant additive was evaluated in comparison to commercially available forming lubricants used in industry, some of which contain hazardous chemicals such as chlorinated paraffins to enable their function. The lubricants were tested by four-ball wear testing, four-ball weld load testing, and bending-under-tension. The ease of cleaning of surfaces formed with the different lubricants was evaluated by methods used in industry and the viscosity was evaluated using standard methods. The CaCO3 mixtures showed a better performance than commercial lubricants in four-ball wear testing, worse performance in four-ball weld load testing, worse cleanability, and a similar development of drawing force in bending-under-tension over 1000 consecutive strokes. When added to fully formed commercial lubricants, the particles degrade the performance of the lubricant in resisting adhesive wear but improve its capacity for resisting abrasive wear. Surfaces of formed parts after bending-under-tension testing with CaCO3 mixtures were scratched, while parts formed using commercial lubricants showed less scratching. The effect of including particles in a commercial lubricant depended on the application, either degrading it or improving it. It is therefore clear that the use of solid particles as lubricant additives should be constrained to selected applications where abrasive wear is a dominant wear mechanism.
Assessment of WRF-CO2 simulated vertical profiles of CO2 over Delhi region using aircraft and global model data
Authors: Ballav Srabanti , Patra Prabir K. , Naja Manish , Mukherjee Sandipan , Machida Toshinobu 
Published: March 2024

AbstractHigh-resolution regional model simulation of CO2 may be more beneficial to reduce the uncertainty in estimation of CO2 source and sink via inverse modeling. However, the study of atmospheric CO2 transport with regional models is rare over India. Here, weather research and forecasting chemistry model adjusted for CO2 (WRF-CO2) is used for simulating vertical profile of CO2 and its assessment is performed over Delhi, India (27.4–28.6° N and 77–96° E) by comparing aircraft observations (CONTRAIL) and a global model (ACTM) data. During August and September, the positive vertical gradient (~ 13.4 ppm) within ~ 2.5 km height is observed due to strong CO2 uptake by newly growing vegetation. A similar pattern (~ 4 ppm) is noticed in February due to photosynthesis by newly growing winter crops. The WRF-CO2 does not show such steep increasing slope (capture up to 5%) during August and September but same for February is estimated ~ 1.7 ppm. Generally, CO2 is quite well mixed between ~ 2.5 and ~ 8 km height above ground which is well simulated by the WRF-CO2 model. During stubble burning period of 2010, the highest gradient within 2.5 km height above ground was recorded in October (− 9.3 ppm), followed by November (− 7.6 ppm). The WRF-CO2 and ACTM models partially capture these gradients (October − 3.3 and − 2.7 ppm and November − 3.8 and − 4.3 ppm respectively). A study of the seasonal variability of CO2 indicates seasonal amplitudes decrease with increasing height (amplitude is ~ 21 ppm at the near ground and ~ 6 ppm at 6–8 km altitude bin). Correlation coefficients (CC) between the WRF-CO2 model and observation are noted to be greater than 0.59 for all the altitude bins. In contrast to simulated fossil CO2, the biospheric CO2 is in phase with observed seasonality, having about 80% at the lowest level and gradually declines with height due to mixing processes, reaching around 60% at the highest level. The model simulation reveals that meteorology plays a significant role of the horizontal and vertical gradient of CO2 over the region.
Mise à jour du diagnostic différentiel et du traitement des douleurs articulaires de la ménopause
Authors: Dan Diana 
Published: March 2024

RésuméLes douleurs articulaires de la ménopause sont une plainte fréquente, qui accompagne les symptômes classiques liés à la déprivation oestrogénique, comme les bouffées de chaleur, les problèmes uro-génitaux et les troubles de l’humeur. Les diagnostics différentiels de la douleur autour de la ménopause sont nombreux et variés, cette période de vie étant marquée par une haute prévalence de maladies rhumatismales. Cet article passe en revue les caractéristiques et la prise en charge de l’arthralgie de la ménopause, discute le diagnostic différentiel et propose une démarche diagnostique de première intention. Quelques pathologies rhumatismales d’intérêt faisant partie du diagnostic différentiel y seront également illustrées de manière succincte.
Trends in use of composite endpoints in clinical trials: A comparison between acute heart failure trials and COVID-19 trials
Authors: Shi Lan , Lindsell Christopher John , Liu Dandan 
Published: March 2024

Abstract
Composite endpoints can encode multiple pieces of information and are increasingly adopted in clinical trials. Advocacy for using composite endpoints began decades ago in cardiovascular trials, leading to incorporation of patient-oriented outcomes and consideration of a hierarchical ranking system. The use of composite endpoints in coronavirus disease (COVID-19) trials has evolved similarly. We conducted a literature review to investigate the use of composite endpoints in acute heart failure and COVID-19 clinical trials. The results showed more frequent use of patient-oriented outcomes and ordinal composite endpoints in COVID-19 trials, which might be driven by global consensus on a set of common outcome measures.
What Does it Take to Become a Judge in Spain? An Informal First Step into a Formal World
Authors: Iglesias Sara , Bustos Gisbert Rafael 
Published: March 2024

AbstractOne of the most prominent informal institutions that affect access to the judicial career is the system of coaching to prepare for the state exams to access the judiciary. This Article focuses on the relevance and impact of that informal institution, together with other informal aspects that affect the process of judicial selection. It is claimed that the system of preparation for judicial state exams has a crucial impact on the composition of the judiciary. Its informality and peculiar features however raise important democratic concerns due to its lack of transparency, the important economic barriers it imposes, and its longstanding impact on judicial culture.