bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating frugality and creativity urgencies: the role of diagnostic use of budgets and goal clarity
Authors: Appuhami Ranjith , Bhuiyan Faruk , Boedker Christina 
Published: April 2024

AbstractOrganizations increasingly promote individual creativity as a strategy to manage their performance and financial strain. Drawing on self-regulation and goal-setting theories, this study examines whether the diagnostic use of budgets stifles or stimulates managers’ creativity directly or indirectly through frugal spending behaviour and perceived goal clarity. Budgetary controls and frugal spending behaviour—with the focus on conserving resources and constraining spending—have traditionally been suggested as hindering individual creativity. However, by analysing survey data collected from middle-level managers in Indonesia, our findings show that the diagnostic use of budgets increases managers’ frugal spending behaviour which, in turn, enhances their creativity. Furthermore, the diagnostic use of budgets increases managers’ perceived goal clarity, with goal clarity and frugal spending behaviour fully mediating the relationship between the diagnostic use of budgets and creativity. The study contributes to the budgeting literature by showing that diagnostic use of budgets encourages managers’ frugal spending behaviour to effectively manage organisational costs and stimulate their creativity.
The public provision of goods in democracies: Do age and inequality matter?
Authors: Mitra Anirban 
Published: April 2024

Abstract
We build a multi-dimensional model of political decision-making with endogenous political parties to analyse the effect of inequality and demography on public spending. Voters differ in terms of income and age. Political competition determines in equilibrium the tax rate and the allocation of revenue between income redistribution and two forms of public spending—a capital good and a neutral good. All agents value the neutral good equally but the young like capital spending more than the old do. We show that the effect of age (resp., inequality) on equilibrium public spending can go in any direction based on the underlying level of inequality (resp., age). Our findings reconcile a large body of seemingly contradictory stylised empirical findings in public economics.
Nonlinear Stability and Asymptotic Behavior of Periodic Wave Trains in Reaction–Diffusion Systems Against $$C_{\textrm{ub}}$$-perturbations
Authors: de Rijk Björn 
Published: April 2024

AbstractWe present a nonlinear stability theory for periodic wave trains in reaction–diffusion systems, which relies on pure $$L^\infty $$

L
∞

-estimates only. Our analysis shows that localization or periodicity requirements on perturbations, as present in the current literature, can be completely lifted. Inspired by previous works considering localized perturbations, we decompose the semigroup generated by the linearization about the wave train and introduce a spatio-temporal phase modulation to capture the most critical dynamics, which is governed by a viscous Burgers’ equation. We then aim to close a nonlinear stability argument by iterative estimates on the corresponding Duhamel formulation, where, hampered by the lack of localization, we must rely on diffusive smoothing to render decay of the semigroup. However, this decay is not strong enough to control all terms in the Duhamel formulation. We address this difficulty by applying the Cole–Hopf transform to eliminate the critical Burgers’-type nonlinearities. Ultimately, we establish nonlinear stability of diffusively spectrally stable wave trains against $$C_{\textrm{ub}}$$

C
ub

-perturbations. Moreover, we show that the perturbed solution converges to a modulated wave train, whose phase and wavenumber are approximated by solutions to the associated viscous Hamilton–Jacobi and Burgers’ equation, respectively.
Impact of the reduction or replacement of NaCl during production and ripening of raw cured pork and turkey sausages
Authors: Wagner Mona , Ploetz Madeleine , Krischek Carsten 
Published: April 2024

AbstractThere are health concerns with regard to the consumption of sodium. Excessive consumption of sodium is suspected to cause high blood pressure, among other things. Therefore, sodium should be reduced or replaced during the production of food. In the present study, in the first part, raw fermented sausages from pork and turkey meat, produced with reduced NaCl concentrations, were investigated. In a second part, the salts, potassium chloride, magnesium chloride, and calcium chloride were added to the sausages, replacing 50% of NaCl. To elucidate, if the reduction or replacement influences the quality of the sausages, physicochemical and microbiological parameters of the products were analyzed. The data show that a reduction of sodium chloride partly influences the hardness and water activity results of raw fermented sausages, made from pork and turkey meat, the redness and nitrite content of the pork sausages, and the ripening losses and total viable counts of the turkey products. Raw fermented sausages with potassium, magnesium, and calcium as partial substitutes for sodium had differing water activity, pH, hardness, and microbiological results using pork and differing pH, hardness, and microbiological results using turkey meat. A bactericidal effect was observed in raw fermented sausages with calcium chloride in inoculation tests with Listeria monocytogenes due to the pH reduction due to calcium. The results indicate that reduction and replacement of NaCl can influence the final products. Therefore, the producers should carefully evaluate before alteration the NaCl content, if this change influences the product acceptability.
Heat transfer in Z-scan experiments
Authors: Miedzinski Rafal , Fuks-Janczarek Izabela , Kassab Luciana R. P. 
Published: April 2024

AbstractIn this study, we present the results of theoretical calculations concerning heat exchange in materials subjected to laser irradiation, with particular emphasis on Z-scan experiments. Using explicit difference methods, we model the temperature distribution in three-dimensional samples of various sizes, such as [4 $$\times$$
×
4 $$\times$$
×
2] mm, [5 $$\times$$
×
5 $$\times$$
×
2] mm, and [6 $$\times$$
×
6 $$\times$$
×
2] mm. The simulations encompass two different types of pulsed lasers with durations of 10 (ns) and 100 (ps), adjusting laser parameters to achieve a peak irradiance intensity of 5 GW/cm$${^2}$$

2

. The temperature distribution in samples, denoted as T(x, y, z, t), is computed using a novel laser heat source model specifically designed for this problem. The computational program Z-lambda enables not only the simulation of thermal processes during the Z-scan experiment but also post-experiment analysis. The development of this software was one of the main objectives of this study. The results indicate that the thermal analysis of Z-scan experiments requires consideration of factors such as laser pulse duration, laser repetition time, sample geometry, and heat exchange between the studied material and the surroundings. Especially in the Z-scan technique, controlling thermal parameters before the experiment is crucial for obtaining precise and reproducible results. It is noteworthy that sample heating during the experiment can significantly influence charge carrier density, subsequently affecting the parameters of nonlinear optics (NLO). Tools like the Z-lambda program allow for the optimization of laser parameters, minimizing sample heating, and reducing the thermal impact on NLO parameters.
The impact of the COVID-19 pandemic on renal cancer care
Authors: Yildirim Hilin , Bins Adriaan D. , van den Hurk Corina , van Moorselaar R. Jeroen A. , van Oijen Martijn G. H. , Bex Axel , Zondervan Patricia J. , Aben Katja K. H. 
Published: April 2024

Abstract
Purpose
To evaluate the impact of the COVID-19 pandemic on renal cell carcinoma (RCC) care in the Netherlands.

Methods
Newly diagnosed RCCs between 2018 and 2021 were selected from the Netherlands Cancer Registry; 2020–2021 was defined as COVID period and 2018–2019 as reference period. Numbers of RCCs were evaluated using 3-week-moving averages, overall and by disease stage and age. Changes in treatment were evaluated with logistic regression analyses. To evaluate possible delays in care, time to start of treatment was assessed. The cumulative number of metastatic RCC (mRCC) over time was assessed to evaluate stage shift.

Results
During the 1st COVID wave (weeks 9–22, 2020), the number of new RCC diagnoses decreased with 15%. Numbers restored partially in 2020, but remained 10% lower compared to 2018/2019. The decline was mostly due to a drop in T1a/T1b RCCs and in age > 70 years. 2021 showed similar numbers of new RCC diagnoses compared to 2018/2019 without an increase due to previously missed RCCs. Treatment-related changes during the 1st COVID wave were limited and temporarily; less surgery in T1a RCCs in favor of more active surveillance, and in mRCC targeted therapy was preferred over immunotherapy. Time to start of firstline treatment was not prolonged during the 1st COVID wave. No increase in mRCC was found until the end of 2021.

Conclusions
The COVID-19 pandemic resulted in fewer RCC diagnoses, especially T1a/T1b tumors. Treatment-related changes appeared to be limited, temporarily and in accordance with the adapted guidelines. The diagnostic delay could lead to more advanced RCCs in later years but there are no indications for this yet.
Associations between gestational weight gain and weight development of the offspring: Differences depending on maternal pre-pregnancy BMI
Authors: Barzen Charlotte , Vogel Mandy , Kiess Wieland , Poulain Tanja 
Published: April 2024

Abstract
Purpose
Obesity rates are rising, and the gestational weight gain (GWG) of most women does not comply with current guidelines. This study assesses the association of pre-pregnancy BMI (ppBMI) and GWG with the child’s weight development and investigates whether associations with GWG differ depending on ppBMI.

Methods
Data were obtained from the cohort study LIFE Child (Germany), comprising 691 mother–child pairs. Children’s weight was followed until age five. Associations between maternal ppBMI, GWG, and children’s weight were evaluated using regression analyses.

Results
The association between GWG and birth weight (BW) was significantly positive in normal and underweight (n/u) women (βGWG = 0.05, p < 0.01, 95% confidence interval (CI) 0.03—0.07), but not in women with overweight or obesity (o/o) (βGWG = 0.0002, p = 0.99, 95% CI −0.03 to 0.03). The risk of giving birth to an infant who was large for gestational age (LGA) increased with rising GWG in n/u women (OR = 1.6, p < 0.01, 95% CI 1.23—2.25). Women with o/o were at increased risk for a LGA baby regardless of GWG (OR = 3, p < 0.01, 95% CI 1.34—6.97). This trend persisted in the child’s weight development during the first 5 years of life.

Conclusion
Women with o/o might increase their offspring’s risk for higher weight at birth and in early childhood. In n/u women, GWG might be the more influential factor. Women should strive for normal weight before conception and should be more attentive to GWG.
The boon and bane of nitrous oxide
Authors: Kronenberg Golo , Schoretsanitis Georgios , Seifritz Erich , Olbrich Sebastian 
Published: April 2024

AbstractNitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be small. The recreational and medical uses of N2O gradually diverged over time. N2O has analgesic and anesthetic effects, making it widely used in modern dentistry and surgery. New research has also begun studying N2O’s antidepressant actions. N-methyl-D-aspartate (NMDA) antagonism and opioid effects are believed to be the main underlying biochemical mechanisms. At this point, numerous questions remain open and, in particular, the conduct of larger clinical trials will be essential to confirm N2O’s use as a rapid-acting antidepressant. The N2O concentration delivered, the duration of a single inhalation, as well as the number of inhalations ultimately required, deserve to be better understood. Finally, the non-medical use of N2O has gained significant attention in recent years. Sudden deaths directly attributed to N2O are primarily due to asphyxia. Heavy, chronic N2O use may result in vitamin B12 deficiency, which, among other things, may cause megaloblastic anemia, venous thrombosis, myeloneuropathy, and skin pigmentation. Helpful biochemical tests include homocysteine and methylmalonic acid. The centerpiece of treatment is complete cessation of N2O use together with parenteral administration of vitamin B12.
Criminal behavior in alcohol-related dementia and Wernicke–Korsakoff syndrome: a Nationwide Register Study
Authors: Palm Anniina , Talaslahti Tiina , Vataja Risto , Ginters Milena , Kautiainen Hannu , Elonheimo Henrik , Suvisaari Jaana , Lindberg Nina , Koponen Hannu 
Published: April 2024

Abstract
Background
Chronic heavy alcohol use may lead to permanent brain damage, cognitive impairment, and dementia. While the link between alcohol use and crime is strong, virtually no research exists on the criminal behavior of patients with the alcohol-related neurocognitive disorders of Wernicke-Korsakoff syndrome (WKS) and alcohol-related dementia (ARD).

Methods
The study population included all persons diagnosed with WKS (n = 1149) or ARD (n = 2432) in Finland in 1998–2015. Data on diagnoses, mortality, and crime were obtained from Finnish nationwide registers. Crime incidences were calculated 4 years before and after diagnosis. Crime types, incidences, and mortality were compared between disorders and with the general population.

Results
Altogether 35.6% of WKS patients and 23.6% of ARD patients had committed crimes in the 4 years preceding diagnosis, most commonly property and traffic crimes, followed by violent crimes. The incidence of criminal behavior decreased significantly after diagnosis; in WKS patients, the standardized criminality ratio (SCR), the ratio of observed to expected number of crimes (95% CI), was 3.91 (3.72–4.10) in 4 years before and 2.80 (2.61–3.00) in 4 years after diagnosis. Likewise, in ARD patients, the SCRs were 2.63 (2.51–2.75) before and 0.84 (0.75–0.92) after diagnosis. No significant difference emerged in mortality between persons with and without a criminal history.

Conclusions
Persons with alcohol-related neurocognitive disorders frequently engage in criminal behavior prior to diagnosis, especially multiple offending. In the 4 years before and after diagnosis, crime rates declined in a linear fashion, with a marked reduction after diagnosis.
Trace element partitioning in the lunar magma ocean: an experimental study
Authors: Haupt Cordula P. , Renggli Christian J. , Rohrbach Arno , Berndt Jasper , Schwinger Sabrina , Maurice Maxime , Schulze Maximilian , Breuer Doris , Klemme Stephan 
Published: April 2024

AbstractModeling the behavior of trace elements during lunar magma ocean solidification is important to further our understanding of the chemical evolution of the Moon. Lunar magma ocean evolution models rely on consistent datasets on how trace elements partition between a lunar silicate melt and coexisting minerals at different pressures, temperatures, and redox conditions. Here we report new experimental trace element partition coefficients (D) between clinopyroxene (cpx), pigeonite, orthopyroxene, plagioclase, olivine (ol), and silicate melt at conditions relevant for the lunar magma ocean. The data include Dcpx−melt at ambient and high pressures (1.5 GPa and 1310 °C), and partition coefficients at ambient pressure for pig, opx, ol, and pl. Overall, clinopyroxene is a phase that may control the fractionation of key geochemical trace element ratios, such as Lu/Hf and Sm/Nd, during the evolution of the lunar magma ocean. We explore the impact of the new silicate Dmineral−melt on the trace element evolution of the lunar magma ocean and we find that accessory phosphate minerals, such as apatite or whitlockite are of critical importance to explain the observed trace element and isotopic signature of the KREEP reservoir on the Moon. The new partition coefficients were applied to calculate the trace element evolution of the residual melts of the crystallizing lunar magma ocean and we propose a new trace element composition for the urKREEP reservoir. The new data will be useful for future thermo-chemical models in order to adequately predict the duration of the lunar magma ocean and the age of the Moon.
Hazard function analysis of prognosis after recurrent colorectal cancer
Authors: Ise Ichiro , Kawai Kazushige , Nakano Daisuke , Takao Misato , Natsume Soichiro , Kato Hiroki , Nakamori Sakiko , Dejima Akira , Yamaguchi Tatsuro 
Published: April 2024

Abstract
Background and objectives
Mean survival time (MST) is used as the indicator of prognosis in patients with a colorectal cancer (CRC) recurrence. The present study aimed to visualize the changes in death risk after a CRC recurrence using hazard function analysis (HFA) to provide an alternative prognostic indicator to MST.

Methods
The medical records of 725 consecutive patients with a recurrence following R0 radical surgery for CRC were retrospectively reviewed.

Results
The five-year, post-recurrence survival rate was 37.8%, and the MST was 3.5 years while the risk of death peaked at 2.9 years post-recurrence. Seven variables were found to predict short-term survival, including the number of metastatic organs ≥ 2, non-surgical treatment for the recurrence, and a short interval before recurrence. In patients with a recurrence in one organ, the MST was four years, the peak time of death predicted by HFA was 2.9 years, and the five-year survival rate was 45.8%. In patients with a surgical resection of the recurrence, the MST was 8 years, the peak time of death was 3.3 years, and the five-year survival rate was 62%.

Conclusions
The present study established a novel method of assessing changes in mortality risk over time using HFA in patients with a CRC recurrence.
The mesenteric entry site as a potential weak point in gastrointestinal anastomoses – findings from an ex-vivo biomechanical analysis
Authors: Cira Kamacay , Janett Saskia Nicole , Micheler Carina , Heller Stephan , Obermeier Andreas , Friess Helmut , Burgkart Rainer , Neumann Philipp-Alexander 
Published: April 2024

Abstract
Purpose
Gastrointestinal disorders frequently necessitate surgery involving intestinal resection and anastomosis formation, potentially leading to severe complications like anastomotic leakage (AL) which is associated with increased morbidity, mortality, and adverse oncologic outcomes. While extensive research has explored the biology of anastomotic healing, there is limited understanding of the biomechanical properties of gastrointestinal anastomoses, which was aimed to be unraveled in this study.

Methods
An ex-vivo model was developed for the biomechanical analysis of 32 handsewn porcine end-to-end anastomoses, using interrupted and continuous suture techniques subjected to different flow models. While multiple cameras captured different angles of the anastomosis, comprehensive data recording of pressure, time, and temperature was performed simultaneously. Special focus was laid on monitoring time, location and pressure of anastomotic leakage (LP) and bursting pressures (BP) depending on suture techniques and flow models.

Results
Significant differences in LP, BP, and time intervals were observed based on the flow model but not on the suture techniques applied. Interestingly, anastomoses at the insertion site of the mesentery exhibited significantly higher rates of leakage and bursting compared to other sections of the anastomosis.

Conclusion
The developed ex-vivo model facilitated comparable, reproducible, and user-independent biomechanical analyses. Assessing biomechanical properties of anastomoses offers an advantage in identifying technical weak points to refine surgical techniques, potentially reducing complications like AL. The results indicate that mesenteric insertion serves as a potential weak spot for AL, warranting further investigations and refinements in surgical techniques to optimize outcomes in this critical area of anastomotic procedures.
Membrane potential dynamics of C5a-stimulated neutrophil granulocytes
Authors: Becker Stina , Swoboda Aljoscha , Siemer Henrik , Schimmelpfennig Sandra , Sargin Sarah , Shahin Victor , Schwab Albrecht , Najder Karolina 
Published: April 2024

AbstractNeutrophil granulocytes play a crucial role in host defense against invading pathogens and in inflammatory diseases. The aim of this study was to elucidate membrane potential dynamics during the initial phase of neutrophil activation and its relation to migration and production of reactive oxygen species (ROS). We performed ROS production measurements of neutrophils from healthy C57BL/6J mice after TNFα-priming and/or C5a stimulation. The actin cytoskeleton was visualized with fluorescence microscopy. Furthermore, we combined migration assays and measurements of membrane potential dynamics after stimulating unprimed and/or TNFα-primed neutrophils with C5a. We show that C5a has a concentration-dependent effect on ROS production and chemokinetic migration. Chemokinetic migration and chemotaxis are impaired at C5a concentrations that induce ROS production. The actin cytoskeleton of unstimulated and of ROS-producing neutrophils is not distributed in a polarized way. Inhibition of the phagocytic NADPH oxidase NOX2 with diphenyleneiodonium (DPI) leads to a polarized distribution of the actin cytoskeleton and rescues chemokinetic migration of primed and C5a-stimulated neutrophils. Moreover, C5a evokes a pronounced depolarization of the cell membrane potential by 86.6 ± 4.2 mV starting from a resting membrane potential of -74.3 ± 0.7 mV. The C5a-induced depolarization occurs almost instantaneously (within less than one minute) in contrast to the more gradually developing depolarization induced by PMA (lag time of 3—4 min). This initial depolarization is accompanied by a decrease of the migration velocity. Collectively, our results show that stimulation with C5a evokes parallel changes in membrane potential dynamics, neutrophil ROS production and motility. Notably, the amplitude of membrane potential dynamics is comparable to that of excitable cells.