bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Characterization and Gas Enhanced Oil Recovery in Tuscaloosa Marine Shale
Authors: Yisa F. O. , Saikia B. D. , Rao D. N. 
Published: March 2024

Abstract
This work experimentally determines the viability of enhanced oil recovery (EOR) by gas injection in core samples from Tuscaloosa Marine Shale (TMS) while investigating the effects of gas type, rock dimension, EOR modes and rock brittleness on the EOR performance. TMS is a promising play in Louisiana with estimated reserves of 7 billion barrels of oil. Experimental studies on EOR performance in several shale plays exist but none have been performed to study its viability in TMS.
An Eagle Ford sample with dimensions 1.0-inch diameter by 1.0-inch length, TMS cores with dimensions 1.0-inch diameter by 1.0-inch length, 1.0-inch diameter by 2.0-inchlength, and 1.5-inch diameter by 3.0-inch length from 5 wells were used for this study. The cores were cleaned prior to vacuuming and saturation with TMS oil. The coreflood experiments were run at a pressure of 2000 psi and temperature of 70°F. Nitrogen (N2) and carbon dioxide (CO2) were used as injectants for the enhanced oil recovery (EOR) experiments. X-ray Diffraction (XRD) was used to determine the mineralogical content of the TMS core plugs.
XRD tests show the fractured cores contain carbonates (5% to 50%) including quartz which makes the rock brittle and more favorable to complex fractures desirable for maximizing recovery in shales, while carbonates are absent in the unfractured cores. Samples E have fractures with higher wt% of quartz and carbonate but lower wt% of clay compared to samples B, C and L. The study shows gas EOR is promising in TMS with CO2 EOR recovery within 22% - 26% compared to N2 EOR recovery within 18% - 19.76%. Gas Assisted Gravity Drainage (GAGD) continuous mode showed higher recovery than GAGD Huff-n-Puff. The ratio of quartz/carbonates to clay in B and C (1.22 - 2.51: 1) was lower compared to the ratio in E (6:1) which explains why B1, B2 and C2 (1.0-in diameter by 2.0-incu length) did not disintegrate prematurely during the experiments compared to E1 with equal dimension. The samples with larger pore volumes, like EL1 (1.5-in diameter by 3.0-in length) displayed more structural integrity than E1(1-in diameter by 2-in length) which disintegrated during its 2nd experiment.
This study shows the potential of gas EOR in TMS shale which is insightful as CO2 sequestration has now become increasingly important. It identifies sweet spots for further exploitation and demonstrates the importance of mineralogical content in geomechanical properties in successfully planning EOR experiments. This extends to field applications of EOR. Furthermore, it reveals important findings regarding optimum saturation periods for shale cores in EOR experiments.
Continuous Feedback Loop Between Surface and Downhole for Autonomously Drilling a Section
Authors: Liu Qiuhua , Ba Samba , Goel Prateek , Kim Jinsoo 
Published: March 2024

Abstract
Advanced AI planner and connected intelligent systems are used to obtain a continuous feedback workflow between surface and downhole. This significantly increases the consistency and efficiency of well construction operations while minimizing human involvement and footprint, advancing efforts towards autonomous operations, and lowering the operational carbon footprints by an order of magnitude.
To send steering instructions to a rotary steerable system (RSS), one often uses modulations of flow or rotation per minute (RPM) called downlinks. The proposed workflow presented here includes an automated downlink detection and an AI planner to determine the optimum downlinking sequence for executing directional drilling decisions. The automated downlink detection is based on an intelligent system that will continuously monitor pressure and RPM waves at the surface and raise an automation event when it detects downlink patterns that match predefined patterns with a certain confidence level. Once the current steering mode is clearly identified and the geometric trajectory to follow has been generated, the next step is to define the optimum downlinking sequence to follow that trajectory path. This is done by the AI planner, which carefully analyzes the current state, the available downlinking map, and the desired state to derive the most favorable path to the desired state.
The autonomous workflow has been tested in the field in many different countries across the world. The automated downlink detection located at the surface has an average detection rate of more than 98% with more than 10,000 downlinks to be detected every month across numerous field locations. On rare occasions, where the surface downlink detection is not picking up the downlink signal, the downhole downlink detection will send downlink confirmation from downhole to surface via the measurement-while-drilling telemetry system. This makes the overall system exceptionally robust. In addition, the intelligent downlink sequence optimization will often find the shortest path from the current tool state to the desired state, thus increasing the efficiency of the drilling operations. With the native cloud monitoring system, domain experts can access the system at any time from wherever they can log into the secure robust network.
The synergy between surface systems and downhole systems has enabled the development of a unique autonomous well construction system that improves performance while reducing the carbon footprint, allowing domain experts from all over the world to remotely monitor their operations without any traveling needed.
Research on coupling coordination between ecological environment and high-quality development in Hebei Province
Authors: He Ling , Du Zhe , Chen Zhesi , Chen Shuqi 
Published: March 2024

Abstract
It is of great significance to explore the ecological environment and high-quality development of Hebei Province and its coupling and coordination degree to promote the integrated development of Beijing-Tianjin-Hebei and realize the harmonious coexistence of human and nature. In this paper, the comprehensive index method is used to evaluate the ecological environment quality and high-quality development; the cold-hot spot analysis is used to analyse the spatial distribution pattern of the ecological environment quality, and the local spatial autocorrelation is used to analyse the spatial correlation characteristics; the coupling coordination degree model and geographic detector are used to measure the spatial correlation characteristics. The results show that: (1) there are obvious differences in the ecological environment quality of Hebei province, the relatively low ecological environment quality area is the most widely distributed, accounting for 42.22% of the total area, mainly in the central and eastern plains, and all levels of ecological environment quality show spatial aggregation characteristics; (2) there are only three levels of high-quality development,namely, relatively high,medium and relatively low, and the medium level has the widest distribution, accounting for 51.66% of the total area, and the province has a large area of distribution; (3) high-quality development and ecological environment quality interaction is significant, most of the regions are in the stage of coordinated development, the interaction between the two systems and the factors within the system synergistic effect is significant, any two factors interact with each other after the effect is greater than a single driving factor. The research results can provide decision-making reference for realizing the modernization of ecological civilization construction, high-quality development and harmonious coexistence between human and nature.
State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis
Authors: Pang Zhiping , Wang Le , Savani Rohan , Bernabucci Matteo , Lu Yi , Singh Ishnoor , Xu Wei , Ouaamari Abdelfattah El , Wheeler Michael , Grill Harvey J , Rossi Mark 
Published: March 2024

Abstract
Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy homeostasis. Glucagon-like peptide-1 (GLP-1, encoded by Gcg), secreted by a distinct population of neurons located within the nucleus tractus solitarius (NTS), suppresses feeding through projections to multiple brain targets1-3. Although GLP-1 analogs are proven clinically effective in treating type 2 diabetes and obesity4, the mechanisms of GLP-1 action within the brain remain unclear. Here, we investigate the involvement of GLP-1 receptor (GLP-1R) mediated signaling in a descending circuit formed by GLP-1R neurons in the paraventricular hypothalamic nucleus (PVNGLP-1R) that project to dorsal vagal complex (DVC) neurons of the brain stem in mice. PVNGLP-1R→DVC synapses release glutamate that is augmented by GLP-1 via a presynaptic mechanism. Chemogenetic activation of PVNGLP-1R→DVC neurons suppresses feeding. The PVNGLP-1R→DVC synaptic transmission is dynamically regulated by energy states. In a state of energy deficit, synaptic strength is weaker but is more profoundly augmented by GLP-1R signaling compared to an energy-replete state. In an obese state, the dynamic synaptic strength changes in the PVNGLP-1R→DVC descending circuit are disrupted. Blocking PVNGLP-1R→DVC synaptic release or ablation of GLP-1R in the presynaptic compartment increases food intake and causes obesity, elevated blood glucose, and impaired insulin sensitivity. These findings suggest that the state-dependent synaptic plasticity in this PVNGLP-1R→DVC descending circuit mediated by GLP-1R signaling is an essential regulator of energy homeostasis.
An assessment on the new impetus of green energy development and its impact on climate change: A non-linear perspective
Authors: Xu Bin , Xu Renjing 
Published: March 2024

Abstract

Green energy is an important path to address global climate change. Evaluating the impact of new economic variables on green energy is a prerequisite for effectively promoting green energy growth. The existing literature has used linear methods to investigate green energy, ignoring the non-linear relationships between economic variables. In view of this, based on the 2005–2021 panel data of China’s 30 provinces, this article adopts a data-driven non-parametric additive model to investigate the impact of new impetus on green energy development. The empirical results reveal that the impact of green finance on green energy development is more prominent in the later stage (a U-shaped impact). Fiscal decentralization also eexerts a positive U-shaped impact, meaning that in the later stage, expanding local fiscal autonomy has contributed to green energy growth. Similarly, the impact of oil prices on green energy shows a positive U-shaped pattern. In addition, the impact of foreign direct investment, environmental pressure, and fixed asset investment also exhibits obvious nonlinear characteristics. Furthermore, this article investigates the impact of green energy on climate change and its impact mechanisms. The results exhibit that the impact of green energy on climate change is gradually becoming prominent (a U-shaped pattern). Mechanism analysis shows that industrial structure and energy structure both peoduce a nonlinear impact on climate change.
Pilot Implementation Outcomes of a Community-Based Tele- Practice Model for Identification and Rehabilitation of Children with Hearing loss within a Public-health system of a Rural District in Southern India
Authors: Satheesh Karishmaa , Ramkumar Vidya , Joshi Deepashree , E Bommi 
Published: March 2024

Abstract

Background
The current study is an effort to evaluate pilot outcomes of a comprehensive tele-practice model for identification and rehabilitation of hearing loss among children below 6 years of age which can then inform suitable adaptations prior to the implementation. The outcomes of tele-facilitator training, limited-efficacy measures, and caregiver acceptability and satisfaction with tele-practice were analysed.
Method
Two special educators were trained as tele-facilitators for tele-diagnostic testing. Screening was done using the validated SRESHT screener in the Perambalur district by trained nurses in UPHC’s at all 4 blocks until at least 5 children with ‘refer’ results were obtained. 5 children with hearing loss using amplification devices enrolled in the District Early Intervention Centre (DEIC) were enrolled for tele-rehabilitation. To measure the limited- efficacy, the outcomes of pre-pilot and post-pilot were compared. The caregiver acceptability and satisfaction with tele-practice was also assessed
Results
In all 12 children with ‘refer’ results loss underwent tele- diagnostic testing. Tele-rehabilitation outcomes were studied on 5 children with hearing loss already using amplification devices. When comparing the outcomes of limited -efficacy with the existing data it was found that the model identified older children with hearing loss. The time lapse between screening/hearing loss suspicion to diagnosis reduced from a median of 216 days to 8 days. For tele- rehabilitation the number of sessions attended in a span of 3 months increased from a median of zero to 3 sessions. Based on the satisfaction questionnaire, most people had a positive experience, and found the travel time to the testing site convenient and affordable. Few parents reported encountering difficulties as a result of inadequate ventilation and internet connectivity within the mobile van where tele-diagnostic testing was conducted.
Conclusion
The pilot outcomes suggests that a block level service enabled using tele- practice to overcome professional shortages, beneficial in reducing time gap between screening/suspicion to diagnosis and also enhanced attendance for rehabilitation. The pilot outcomes provided insights on adaptations related to screening site, test infrastructure and internet optimization that may be required before implementation.
Perceptions of Antenatal Attendees on Prevention of Mother-to-Child Transmission of Human Immunodeficiency Virus (HIV) Services in the Central Region of Ghana.
Authors: Opoku-Danso Rita , Habedi Debbie 
Published: March 2024

Abstract

Background: Prevention of Mother-to-Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) involves a range of interventions that can be implemented during pregnancy, delivery, and breastfeeding to reduce the risk of HIV transmission from mother to the child. However, the success of PMTCT programs largely depends on the uptake of services and the perceptions of the target population.
Aim:This study therefore aims to explore the perceptions of antenatal attendees on PMTCT services in the district hospitals in the central region of Ghana.
Methods: A descriptive cross-sectional study with a quantitative approach was conducted using antenatal attendees between the ages of 15 to 49 in the 11 district hospitals in the central region of Ghana. The convenient sampling procedure was used to sample 448 antenatal attendees from the district hospitals. Data were collected using a structured questionnaire. Statistical Package for Social Sciences (SPSS) version 25 was used to proceed the data.Descriptive and inferential statistics were used to analyzed the data. ANOVA was used to assess the statistical significance of difference between perceptions, beliefs and views among antenatal attendees across the three gestational ages.
Results: A total of 448 antenatal attendees were included in the study. Two hundred and nineteen (48.9%) perceived receiving poor care from midwives when tested positive, 318 (71%) admitted that they fear stigmatization associated with PMTCT of HIV services, 224 (50%) of them admitted that distance to the ANCs was a bother to them and 258 (57.6%) were uncomfortable to use condom for HIV prevention. Anova test reported statistically as perception [F (degree of freedom of the groups) = F-statistic 8.957; p-value = 0.001: p<0.05) beliefs, [F (degree of freedom of the groups) = F-statistic 3.138; p-value = 0.025: p<0.05) and views, [F (degree of freedom of the groups) = F-statistic 3.287; p-value = 0.021: p<0.05).
Conclusion: The antenatal attendees generally had poor perceptions towards the services, hence, affecting their participation in the services available. Thus, they had the perceptions of receiving poor care from ANC midwives, feared experiencing stigma when tested positive, hospitals located far from their homes and discomfort with the use of condoms to prevent further transmissions and complications. Also, the advancement in gestational age improves the antenatal attendees’ perception on PMTCT of HIV services.
Induction of complementary immunogenic necroptosis and apoptosis cell death pathways inhibits cancer metastasis and relapse
Authors: Achilefu Samuel , Egbulefu Christopher , Black Kvar , Su Xinming , Karmakar Partha , Habimana-Griffin LeMoyne , Sudlow Gail , Prior Julie , Onejeme Ezugo , Zheleznyak Alexander , Xu Baogang , Xu Yalin , Esser Alison , Mixdorf Matthew , Moss Evan , Manion Brad , Reed Nathan , Gubin Matthew , Lin Chieh-Yu , Schreiber Robert , Weilabaecher Katherine N. 
Published: March 2024

Abstract
Interactions of light-sensitive drugs and materials with Cerenkov radiation-emitting radiopharmaceuticals generate cytotoxic reactive oxygen species (ROS) to inhibit localized and disseminated cancer progression, but the cell death mechanisms underlying this radionuclide stimulated dynamic therapy (RaST) remain elusive. Using ROS-regenerative nanophotosensitizers coated with a tumor-targeting transferrin-titanocene complex (TiO2-TC-Tf) and radiolabeled 2-fluorodeoxyglucose (18FDG), we found that adherent dying cells maintained metabolic activity with increased membrane permeabilization. Mechanistic assessment of these cells revealed that RaST activated the expression of RIPK-1 and RIPK-3, which mediate necroptosis cell death. Subsequent recruitment of the nuclear factors kappa B and the executioner mixed lineage kinase domain-like pseudo kinase (MLKL) triggered plasma membrane permeabilization and pore formation, respectively, followed by the release of cytokines and immunogenic damage-associated molecular patterns (DAMPs). In immune-deficient breast cancer models with adequate stroma and growth factors that recapitulate the human tumor microenvironment, RaST failed to inhibit tumor progression and the ensuing lung metastasis. A similar aggressive tumor model in immunocompetent mice responded to RaST, achieving a remarkable partial response (PR) and complete response (CR) with no evidence of lung metastasis, suggesting active immune system engagement. RaST recruited antitumor CD11b+, CD11c+, and CD8b+ effector immune cells after initiating dual immunogenic apoptosis and necroptosis cell death pathways in responding tumors in vivo. Over time, cancer cells upregulated the expression of negative immune regulating cytokine (TGF-β) and soluble immune checkpoints (sICP) to challenge RaST effect in the CR mice. Using a signal-amplifying cancer-imaging agent, LS301, we identified latent minimal residual disseminated tumors in the lymph nodes (LNs) of the CR group. Despite increased protumor immunogens in the CR mice, RaST prevented cancer relapse and metastasis through dynamic redistribution of ROS-regenerative TiO¬2 from bones at the early treatment stage to the spleen and LNs, maintaining active immunity against cancer progression and migration. This study reveals the immune-mechanistic underpinnings of RaST-mediated antitumor immune response and highlights immunogenic reprogramming of tumors in response to RaST. Overcoming apoptosis resistance through complementary necroptosis activation paves the way for strategic drug combinations to improve cancer treatment.
Workplace Learning: The Bidirectional Relationship between Stress and Self-Regulated Learning in Undergraduates
Authors: Marsch Stephan , Yanagida Takuya , Steinberg Evelyn 
Published: March 2024

Abstract

The present study focused on the relationships between various aspects of self-regulated learning (SRL) and stress among undergraduate health science students in workplace settings. Although both constructs are associated with academic achievement (Ahmady et al., 2021; Cho et al., 2017), it is still unclear how they influence each other. Using longitudinal data, the aim of the present study was to examine whether perceived stress in the previous week impacts SRL-aspects in the current week and, conversely, whether SRL-aspects in the previous week impacts stress in the current week.
Subjects were 192 undergraduate health sciences students in their workplace placements. SRL-aspects and stress were assessed using scales and previously tested single-item measures. The 21 SRL-aspects used in this study included cognition (learning strategies), motivation, emotion, perception of the learning environment, and regulation of these areas on a metalevel (monitoring and control). Data collected over 15 weeks were analyzed using multilevel vector autoregressive models, with the data nested within weeks and one model dedicated to each SRL-aspect and its relationship with stress.
Among the 21 path estimates assessing the impact of prior stress on individual SRL-aspects, 10 were statistically significant. For individual SRL-aspects impacting stress, 7 out of 21 paths were statistically significant (p < .05). Notably, no model showed statistical significance of effects in both directions. Except for two results, cross-lagged relationships were negative, indicating that better SRL-aspects from the previous week resulted in reduced stress in the current week and vice versa. The effects for the cross-lagged paths from SRL-aspects to stress were predominantly of medium size, whereas the influence of stress on individual SRL-aspects was predominantly small.
The present study highlights a potentially causal and mostly negative relationship between stress and various aspects of SRL, but also that the individual relationships require differentiated consideration. The results can be used to develop targeted interventions in the practical part of the training of health science students to reduce stress and improve specific aspects of SRL. Furthermore, these findings underscore assumptions regarding connections between anxiety and increased stress, negative relationships between stress and motivation, and the importance of effective time management strategies for stress reduction.