bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORPHEA WITH HIGH TITER OF FIBRONECTIN ANTIBODIES
Authors: STEFANATO CATHERINE M. , GORKIEWICZ‐PETKOW ANNA , JARZABEK‐CHORZELSKA MARIA , JABLONSKA STEFANIA , CHORZELSKI TADEUSZ 
Published: May 2007

AbstractA 20‐year‐old man with a 9‐year history of unusual subcutaneous morphea with nodular lesions in a circular arrangement and wooden‐hard symmetrical induration of the arms, had high liters of fibronectin antibodies. A possible role of fibronectin and antifibronectin antibodies in the pathogenesis of scleroderma is discussed.
SURVEY OF SKIN LESIONS IN THE FILIPINO ELDERLY
Authors: TIANCO ELIZABETH AMELIA V. , BUENDIA‐TEODOSIO GRACIA , ALBERTO NENITA L. 
Published: May 2007

AbstractOne hundred elderly Filipino patients, aged 60 and over were surveyed to identify past and present skin complaints, and the dermatologic findings on a total cutaneous examination. All patients were consulting at the dermatology clinical of a teaching hospital in the Philippines. The elderly were keen to recall past hypersensitivity reactions because of their dramatic symptoms. The most common dermatologic problem prompting consultation was lichen simplex chronicus. Although the population size was limited, dermatoses in the Filipino elderly were not uncommon, and they were also subject to the stigmata of aging. Similarities and differences to two American surveys are noted.
FACIAL PYOGENIC GRANULOMA‐LIKE LESIONS UNDER ISOTRETINOIN THERAPY
Authors: HAGLER JOSEPH , HODAK EMMILIA , DAVID MICHAEL , SANDBANK MIRIAM 
Published: May 2007

AbstractA male patient with severe cystic acne was treated with 13‐cis‐retinoic acid in a dosage of 1 mg/kg/day. Early flare‐up of his acne and multiple pyogenic‐like lesions on his face appeared during the second week of isotretinoin treatment. Histologic study of the lesions revealed granulation tissue. Possible etiologies for this phenomenon are discussed.
LYMPHEDEMA TREATED BY MICROWAVE AND ELASTIC DRESSING
Authors: OHKUMA MORIYA 
Published: May 2007

AbstractFor lymphedema, surgical treatment is contraindicated and other conservative treatments including oral medicine are not sufficient. Treatment with microwave and elastic dressing has been evaluated in 30 cases of lymphedema with 11 control patients who received only one of the two treatments. Twenty‐four patients were effectively treated. In six, edema was not decreased as compared with reduction due to daily physical activity. It was observed that the earlier the patient was treated after onset of edema, the better the results. Six of 10 control patients who received only elastic dressing showed slight decrease in edema. A patient who received only microwave did not show any improvement. There was no recurrence in half of the treated patients. Treatment of lymphedema by microwave and elastic dressing appears satisfactory, particularly when given at an early stage of the disease.
BIOEQUIVALENCE OF TOPICAL CORTICOSTEROIDS: A REGULATORY PERSPECTIVE
Authors: WILLIAMS ROGER L 
Published: May 2007

AbstractAfter reviewing the history of generic drug substitution policy in the United States, this paper discusses issues of equivalence as they apply to topical drug products. Documentation of bioequivalence of topical products has been problematic, and current methods are being re‐evaluated by the Food and Drug Administration, The FDA is currently evaluating various extensions of the basic methodology of the Stoughton‐McKenzie vasoconstrictor assay, in order to develop a more comprehensive pharmacodynamic methodology for documenting topical drug bioequivalence. A modern pharmacodynamic model is described, based on nonlinear dose‐response relationship, a baseline effect, and a maximum or plateau effect. The Agency's goal is a bio‐equivalent methodology that will be simple, readily performed, and based on more objective methods of measuring the vasoconstrictor response.
TOPICAL CORTICOSTEROIDS: QUALITY CONTROL CONSIDERATIONS
Authors: SHAH VINOD P. 
Published: May 2007

AbstractA simple procedure is developed, which can be used as a quality control test. The method utilizes commercially available diffusion cell assembly, synthetic membrane, and an appropriate receptor phase. The amount of drug released over time is determined using an HPLC method. From this, the drug release rate, flux, μg/cm2/min0.5 is calculated. This drug release rate can serve as a good quality control test to assure batch‐to‐batch uniformity.
PEDIULOSIS CAPITIS IN ISTANBUL
Authors: AYDEMIR ERTUǦ;RUL HASBI , ÜNAL GAVE , KUTLAR MELTEM , ONSUN NAHIDE 
Published: May 2007

Abstract Background. Pediculosis capitis is a worldwide problem. We studied the prevalence of this infestation in Istanbul. Methods. We reviewed the records of the Dermatology Clinic of istanbul University Cerrahpaşa Medical Faculty from a 20–year period (1970–1989). Results. The number of cases of pediculosis capitis have gradually increased over this period, with a peak in 1981. Women are more involved than men. There has been a significant increase in cases in children of school and preschool ages. Conclusions. Many factors may have contributed to this increase: poor hygiene and socioeconomic conditions, lack of medical training, and probably some resistance to pediculicide preparations in the lice. The stigma attached to the disease may prevent people from coming forward.
ERYTHEMA NODOSUM VERSUS NODULAR VASCULITIS
Authors: VICO MARIA‐DOLORES SANZ , DE DIEGO VICTOR , YUS EVARISTO SÁNCHEZ 
Published: May 2007

Abstract Background. Erythema nodosum (en) is usually considered to be a septal panniculitis, and nodular vasculitis (nv) a lobular panniculitis. We tested the usefulness of this histologic classification in clarifying a frequent clinical dilemma: en versus nv. Methods. Over 3 years 109 patients with panniculitis were included in this study. After a history and a physical examination, a clinical diagnosis was made according to well‐established criteria. Results. From the study of 88 patients, we concluded that in the clinically typical cases, the clinico‐pathologic agreement was 93% and 94% for en and nv respectively, whereas it diminished to 79%, 72%, and 67% in the cases clinically diagnosed as en migrans, atypical en, and atypical nv, respectively. Moreover, septal and lobular panniculitis were always two clear‐cut, different, opposite patterns of hypodermal inflammation to these conditions. Conclusions. In the absence of a known pathogenetic mechanism, the histopathology remains the most objective discriminating marker between en and nv, mainly in the clinically atypical and doubtful cases.
NON‐MELANOMA SKIN CANCER AND KERATOACANTHOMA IN FILIPINOS: AN INCIDENCE REPORT FROM KAUAI, HAWAII
Authors: CHUANG TSU‐YI , REIZNER GEORGE T. , ELPERN DAVID J. , STONE JENNY L. , FARMER EVAN R. 
Published: May 2007

Abstract Background. Non‐melanoma skin cancer is the most common malignancy in the white population of the United States with an estimated 700,000 new cases each year. Regrettably, data on minority racial groups are either scarce or lacking entirely. Methods. This study was designed as a 5‐year prospective incidence study of non‐melanoma skin cancer and keratoacanthoma by using an island‐wide survey of Kauai's Filipino residents and covers the years of 1983 to 1987. Results. Seven basal cell carcinoma (incidence: 12.3/ 100,000), one squamous cell carcinoma (incidence: 1.8/ 100,000) and four keratoacanthoma (incidence: 7/100,000) patients are reported. Conclusions. To the best of our knowledge, this is the first population‐based incidence report on non‐melanoma skin cancer and keratoacanthoma in this population.
RISK OF CANCER IN RELATIVES OF PATIENTS WITH CUTANEOUS MELANOMA
Authors: OSTLERE LUCY S. , HOULSTON RICHARD S. , LAING JAMES HAMISH E. , RUSTIN GORDON J.S. , RUSTIN MALCOLM H.A. 
Published: May 2007

Abstract Background. Cutaneous malignant melanoma (CMM) is a recognized feature of the Lynch type II cancer‐family syndrome and the Li‐Fraumeni's syndrome. A significant contribution of these syndromes to the total burden of CMM would be reflected in an increased risk of nonmelanoma cancers in first degree relatives. Methods. Pedigrees were taken from 85 patients with CMM using a family history questionnaire. The relative risk of death from all cancers and individual cancers in first degree relatives was calculated. Results. Of the 85 questionnaires, those of 79 patients were completed and of adequate quality for analysis. The first degree relatives of CMM patients showed no increased risk of cancer death, the relative risk of cancer death being 1.0. Six patients (7.6%) had first degree relatives with CMM. One patient had a family history compatible with the dominant transmission of a predisposition to cancer. Conclusions. It is important to establish whether an increased cancer risk is present in relatives of patients with malignancies so that screening programs may be offered. This study provides little evidence to support seeing relatives for noncutaneous malignancies in the absence of a dominant family history of predisposition to cancers. The increased frequency of CMM in relatives suggests that relatives of CMM patients should be counseled on protection from the sun and examination of the skin for melanoma.
AGGRESSIVE TRICHOEPITHELIOMA VERSUS KERATOTIC BASAL CELL CARCINOMA
Authors: SAN JUAN ELIANA B. , GUANA ADRIANA L. , GOLDBERG LEONARD H. , KOLBUSZ ROBERT V. , ORENGO IDA F. , ALFORD EUGENE 
Published: May 2007

A 43‐year‐old white man presented with an infiltrative le‐sion on the left nasolabial fold, which had grown slowly over 15 years. There was a history of moderate sun expo‐sure. Prior history was negative for cutaneous carcinomas. Family history was negative for trichoepithelioma. Physical examination revealed a patient with a fair complexion, blue eyes, light skin, and light brown hair. There was evidence of severe actinic damage manifested by marked solar elas‐tosis of the face. A 1.5 × 1.3 cm infiltrative, depressed, skin‐colored plaque, with elevated pearly borders was noted on the left nasolabial fold. There was nodule formation with superficial ulceration in the center of the lesion (Fig. 1). No other skin tumors were present.A punch biopsy showed a deeply infiltrating tumor. Sub‐sequently, the tumor was excised by Mohs micrographic surgery in six stages, revealing deep and wide clinically un‐detected invasion into the orbicularis oris, zygomaticus minor, and the levator labii superioris muscles. The final size of the defect was 5.0 × 5.0 cm (Fig. 2). Reconstruction was later performed by otolaryngology with satisfactory results. Pathological Study: The tumor was composed of multiple islands of basaloid cells embedded in a dense fibrotic stro‐ma. Some islands showed peripheral palisading of their cells (Fig. 3). Other areas contain numerous horn cysts with abrupt and complete keratinization surrounded by basaloid cells (Fig. 4). Areas of calcification and foreign body reac‐tion are present secondary to ruptured cysts. Stromal‐stro‐mal clefting characteristic of trichoepithelioma is seen adjacent to some tumor islands (Fig. 5). The tumor infil‐trates into the underlying muscle (Fig. 6). Stromal muco‐polysaccharide deposition and stromal‐tumor separation as seen in basal cell carcinoma (BCC) were not present.
DESMOPLASTIC TRICHOEPITHELIOMA AND MULTIPLE EPIDERMAL CYSTS
Authors: SUMITHRA SAMBAMURTHY , JAYARAMAN MURYGAIYA , YESUDIAN PATRICK 
Published: May 2007

A 22‐year‐old peanut vendor presented with an asympto‐matic annular plaque of 2 years duration on his face. It began as a small, firm papule and gradually increased in size and extent. His occupation involved long hours of ex‐posure to sunshine, but there was no associated burning sensation or irritation.Dermatologic examination revealed an oval, annular plaque over the right temple, about 4 cm × 3 cm. The rim was studded with miliary white papules 1 to 2 mm in size, and the center was depressed (Fig. 1). It had an indurated feel and was freely mobile over the underlying structures. Clinically, a differential diagnosis of colloid milium, granu‐loma annulare, or annular elastolytic granuloma was enter‐tained. In addition, numerous milia were scattered over the cheeks. He also had multiple, well‐defined, firm, white scro‐tal swellings, 1 to 3 cm in size. Systemic examination did not reveal any abnormality.Skin biopsies of the plaque and a scrotal cyst were per‐formed, and the sections stained with hematoxylin and eosin. The annular plaque, showed mild hyperplasia of the epidermis, numerous keratin cysts, islands of basophilic cells in the dermis, and abundant fibrous tissue compress‐ing the tumor cells into narrow strands (Fig. 2). Tumor stro‐mal retraction was conspicuous by its absence. A diagnosis of desmoplastic trichoepithelioma was made.The scrotal nodule revealed an epidermal cyst lined by stratified squamous epithelium and containing laminated keratin (Fig. 3). The patient was referred to the department of plastic surgery, where the plaque was excised in toto, and the defect repaired.
FATAL CHICKENPOX IN A PATIENT WITH NEPHROTIC SYNDROME
Authors: MATÉ EVA S. , FISHER BENJAMIN K. 
Published: May 2007

Abstract Background. We report our experience with two patients with adult onset of chickenpox in the setting of longstanding steroid therapy for nephrotic syndrome. Ours is a 430‐bed tertiary care teaching hospital. The Wellesley Hospital, Toronto, Ontario. Both patients presented as self‐referrals to the emergency department. Methods. The clinical suspicion of chickenpox was rapidly confirmed in both cases by a Tzanck smear preparation, by viral cultures of the vesicle, serology, and skin biopsy. In both patients therapy with high dose acyclovir, 10 mg/kg q8h, intravenously, was instituted based on clinical presentation. Results. Delay in clinical recognition and treatment in our first case resulted in death due to multiorgan failure (MOF). Improved awareness and rapid treatment of the second patient had a favorable outcome with no sequelae. Conclusions. Chickenpox is not only a childhood illness. Although rare in the adult population, it is associated even in the nonimmunocompromised host with increased morbidity and mortality. Steroid therapy predisposes to early dissemination and a potentially fatal outcome. Adults with immunosuppression should receive prompt systemic treatment with acyclovir.
LEISHMANIASIS RECIDIVA CUTIS IN AMERICAN CUTANEOUS LEISHMANIASIS
Authors: BITTENCOURT ACHILÉA L. , COSTA JACKSON M.L. , CARVALHO EDGAR M. , BARRAL ALDINA 
Published: May 2007

Abstract Background. Leishmaniasis recidiva cutis (LRC) consists of active lesions around or inside the scar of classical cutaneous leishmaniasis (CL). In the literature it is considered as an hyperergic form of CL because the patients show a strong response to intradermal testing with leishmania antigen and, histologically, the parasites are scarce or absent; a well‐organized granuloma is always observed. Methods. Three patients from Bahia (Brazil) with LRC were evaluated by clinical examination, biopsies, skin tests with leishmania antigen, serology, and culture. In addition, a specific lymphocyte blastogenesis test was done and the species of leishmania characterized. Results. The disease was caused by both L. amazonensis and L braziliensis and serological titers varied from 1/16 to 1/64. The patients presented histologic and immunologic aspects different from those referred to in the literature. From four biopsies obtained only two presented a granulomatous reaction and parasites varied from absent to a parasite index 3. In one patient an absence of T cell response to leishmania antigen was observed in the first evaluation with restoration of the response after cure. In the other two, the degree of the specific proliferative response was lower than that usually observed in patients with classical CL. Conclusions. These findings indicate that New World LRC can not be considered a hyperergic form of CL. With respect to its clinical aspects and response to treatment, LRC must be considered as an entity different from the classical CL.
AMERICAN CUTANEOUS LEISHMANIASIS: INTERMEDIATE FORM
Authors: HALMAI‐STUPAR OLGA , AROSEMENA‐SARKISSIAN REYNALDO , PAEZ ERICA , WEISS EDUARDO , RONDON ANTONIO 
Published: May 2007

A man of Portuguese nationality presented with increased volume of the forehead and multiple pustules, which subsequently ulcerated. The pustules appeared progressively on the rest of the face and in the right scapular region during a period of 2 years.Physical examination revealed multiple rounded ulcers of different sizes with erythematous and infiltrated borders covered by serosanguineous scabs on the face and right scapular region (Figs. 1 and 2).The otorhinolaryngologic examination showed an infiltrate of granulomatous aspect in the anterior third of the septum. Posterior rhinoscopy was normal.When the patient was first seen, complete hematology and hepatic and renal tests were normal. Additional tests included: HIV, nonreactive; venereal disease reference laboratory test, nonreactive; chest x‐ray, normal; Montenegro skin test, 14 mm; purified protein derivative, 0 mm.The skin biopsy revealed a granulomatous infiltrate with a dense infiltrate composed principally of plasmocytes, with few lymphocytes (Fig. 3).A skin smear stained with Giemsa and culture of biopsy material in blood agar were positive for the presence of Leishmania. Antibodies against Leishmania measured in an ELISA test were strongly positive, titer 1:6400. Typing of the isolate using absorbed polyclonal antisera revealed Leishmania braziiiensis.During hospitalization, the patient received systemic immunotherapy with a combined vaccine containing heat‐killed Leishmania mexicana promastigotes and bcg,1,2 as well as chemotherapy with meglumine antimoniate in a dose of 50 mg/kg/day IM, two cycles of 20 days with an in‐terval of 7 days of rest.The patient presented clinical healing of his lesions without relapse during a 2 year follow up after completion of therapy.
ROLE OF EMOTIONAL FACTORS IN ADULTS WITH ATOPIC DERMATITIS
Authors: GINSBURG IONA H. , PRYSTOWSKY JANET H. , KORNFELD DONALD S. , WOLLAND HENRIETTA 
Published: May 2007

Abstract Background. The role of anger in the onset or perpetuation of episodes of atopic dermatitis in adults has long been considered an important factor. The objective was to investigate whether atopic patients feel ineffective in dealing with anger and assertiveness when compared with psoriasis patients and control patients. Methods. Thirty‐four adult patients with atopic dermatitis were compared to 28 patients with psoriasis and 32 controls, dental patients without major skin disease. Standard measures of anxiety, anger, assertion, depression, and locus of control as well as a measure of anger effectiveness, designed for this study, were used. Results. There were significant differences between atopic dermatitis patients and controls in that atopics felt angry more readily but were less likely to express it, were more anxious and less assertive, and felt less effective in expressing anger. The only difference between psoriasis patients and controls was less ability to express anger. Atopic patients were more chronically anxious than those with psoriasis. Conclusions. Adult atopic dermatitis patients are often chronically anxious and feel ineffective in handling anger which suggests that psychological interventions may prove helpful.
STUDY OF THE PARTNERS OF WOMEN WITH HUMAN PAPILLOMAVIRUS INFECTION
Authors: KOKELJ FRANCO , BARAGGINO EZIO , STINCO GIUSEPPE , WIESENFELD URI 
Published: May 2007

Abstract Background. Genital human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases, and it has been identified as a significant risk factor for the development of dysplasia and cancer of the uterine cervix. The possible influence of male HPV lesions on female cervix oncogenesis has not been elucidated so far. In the present study we evaluate the male partners of women with clinical or subclinical HPV infection with particular interest in the clinical features of this infection in both partners. Methods. We examined 81 male partners of women affected with human papillomavirus infections. Condylomata acuminata were searched for by visual inspection. Subclinical lesions were searched by 5 power optical magnification lens after application of 5% acetic acid. Results. In men we observed the following percentage of infection: 67% of the partners of women affected with condylomata acuminata, 46% of the partners of women affected with subclinical lesions (acetic acid positive), and 40% of the partners of women with association of HPV and cervical intraepithelial neoplasia. Conclusions. Our data stress that very often the partners of women with HPV subclinical infection, especially when associated with CIN, do not present lesions, and consequently primary prevention may be very difficult.
XERODERMA PIGMENTOSUM VARIANT: DNA PLOIDY ANALYSIS OF VARIOUS SKIN TUMORS AND NORMAL‐APPEARING SKIN IN A PATIENT
Authors: CHI HYUNG‐IN , KAWACHI YASUHIRO , OTSUKA FUJIO 
Published: May 2007

Abstract Background. The patient with xeroderma pigmentosum provides an appropriate human model for the evaluation of tumor development and progression. Methods. We describe a patient with variant‐type xeroderma pigmentosum who developed actinic keratoses, a squamous cell carcinoma, and its metastasis into a lymph node. DNA ploidy was measured and analyzed in cells of these tumors and the patient's sun‐exposed as well as sun‐shielded skin. Results. The sun‐shielded skin showed a normal diploid dna distribution pattern, while the sun‐exposed skin had an increased number of hyperdiploid cells. The actinic keratosis showed further increased hyperdiploid cells. The squamous cell carcinoma showed a large number of hyperdiploid cells and formed an aneuploid cell fraction. Histographically, the aneuploid cell fraction became more apparent and was revealed to be a major fraction in the metastatic squamous cell carcinoma. Conclusions. The changes in the DNA ploidy pattern well reflect the clinical and histologic characteristics of the respective skin conditions and likely provide the cellular basis for the sequential or stepwise carcinogenic process in the patient's xeroderma pigmentosum skin. Further studies are necessary to determine whether the present results explain the similar carcinogenic process in sun‐damaged skin of the nonpredisposed general population.
SENILE DRY SKIN TYPE SJÖGREN'S SYNDROME
Authors: ASO KAZUO 
Published: May 2007

Abstract Background. Elderly patients may show asteatotic dermatitis complicating Sjögren's syndrome (sjs) that we have named “senile dry skin type sjs.” To define the condition further, we have examined a group of patients with sjs and have recorded clinical and laboratory findings in these patients. Patients and Materials. Of the 36 patients, 11 were men and 25 were women, with a mean age of 72 years. In addition to the subjective sensation of dryness of the eyes and oral cavity and objective signs of dryness revealed by the Schirmer test, the rose bengal test, minor labial gland biopsy, and sialography were carried out, as well as other hematologic and immunologic tests. Results. The following abnormal laboratory tests were found: elevated erythrocyte sedimentation rate (85%), mild hepatic dysfunction (50%), and anemia (45%), leukopenia (42%), and thrombocytopenia (16%). Immunologic abnormalities were also observed, such as: positive antinuclear antibody (55%), an increase in gamma globulin (28%), and a positive rheumatoid factor (20%). In 11 of the 36 patients (30%), the subjective sensation of dryness was absent and only objective signs of dryness were present. Conclusions. The present study suggests that dry–skin–dermatitis associated with sjs is rather common in the elderly.