bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-utility analysis of primary HPV testing through home-based self-sampling in comparison to visual inspection using acetic acid for cervical cancer screening in East district, Sikkim, India, 2023
Authors: Hariprasad Roopa , Bagepally Bhavani Shankara , Kumar Sajith , Pradhan Sangeeta , Gurung Deepsikka , Tamang Harki , Sharma Arpana , Bhatnagar Tarun 
Published: March 2024

AbstractIntroductionPrimary Human Papilloma Virus (HPV) testing offers higher sensitivity and specificity over Visual Inspection using Acetic acid (VIA) in cervical cancer screening. Self-sampling is a promising strategy to boost participation and reduce disparities. However, concerns about the initial costs hinder HPV testing adoption in low and middle-income countries. This study assesses the cost-utility of home-based HPV self-sampling versus VIA for cervical cancer screening in IndiaMethodsA cross-sectional study was conducted in East district, Sikkim, India, comparing the costs and utility outcomes of population-based cervical cancer screening through VIA and primary HPV screening through self-sampling. Cost-related data were collected from April 2021 to March 2022 using the bottom-up micro-costing method, while utility measures were collected prospectively using the EuroQoL-5D-5L questionnaire. The utility values were converted into quality-adjusted life days (QALDs) for an 8-day period. The willingness to pay threshold (WTP) was based on per capita GDP for 2022. If the calculated Incremental Cost-Effectiveness Ratio (ICER) value is lower than the WTP threshold, it signifies that the intervention is cost-effective.ResultsThe study included 95 women in each group of cervical cancer screening with VIA & HPV self-sampling. For eight days, the QALD was found to be 7.977 for the VIA group and 8.0 for the HPV group. The unit cost per woman screened by VIA and HPV self-testing was ₹1,597 (US$ 19.2) and ₹1,271(US$ 15.3), respectively. The ICER was ₹-14,459 (US$ −173.6), which was much below the WTP threshold for eight QALDs, i.e. ₹ 4,193 (US$ 50.4).ConclusionThe findings support HPV self-sampling as a cost-effective alternative to VIA. This informs policymakers and healthcare providers for better resource allocation in cervical cancer screening in Sikkim.
A protocol for the comparison of telephone and in-person interview modalities: duration, richness, and costs in the context of exploring determinants of equitable access to community health services in Meru, Kenya
Authors: Allen Luke N , Karanja Sarah , Tlhajoane Malebogo , Tlhakanelo John , Macleod David , Bastawrous Andrew 
Published: March 2024

AbstractBackgroundOur research team is conducting phenomenological interviews with people who have not been able to access health services in Meru County, Kenya, aiming to explore the barriers they face and their perceptions of how we could modify our community outreach services to improve accessibility. We plan to conduct an embedded study that compares in-person and telephone interview modalities in terms of the richness of the data and the resources required for each modality.Methods/DesignThis is a qualitative mode comparison study, embedded within a broader project to understand and address the issues that lead to inequitable access to local outreach clinics in Kenya. We will recruit at least 40 people who have been referred to local services but who have not been able to attend. We will conduct in-person interviews with half of these people, and telephone interviews with the other half. We will use random numbers to determine the modality that is used for each participant. All interviews will be conducted in the same month by a team of six research assistants who will use the same topic guide and analytic matrix for each interview. For all interviews conducted in each mode we will record and compare the mean duration; mean number of themes reported by each participant; total number of themes reported; interviewer rating of perceived richness; interviewer rating of perceived ease of building rapport; number of days taken by the team to complete all interviews; and all costs associated with conducting the interviews.DiscussionThe findings will help us to weigh up the relative strengths and weaknesses of each modality for our research context. Given that we are exploring a focused research question in a fairly homogenous population, we anticipate that there may not be a meaningful difference in the number of themes reported.
T2DFitTailor: A tool for type 2 diabetes patients to tailor exercise plan
Authors: Liu Cheng , Hou Xinyu , Xu Bingxiang , Liu Tiemin , Wang Ru 
Published: March 2024

AbstractType 2 Diabetes (T2D) poses a formidable global health challenge, with its escalating prevalence contributing significantly to increased morbidity, mortality, and healthcare costs. This chronic condition, characterized by insulin resistance and hyperglycemia, leads to a plethora of complications, intensifying its societal and economic impact. Exercise, as a fundamental element of T2D management, is universally recommended for its ability to improve glycemic control and mitigate cardiovascular risks. However, individual responses to exercise vary considerably among T2D patients, leading to inconsistencies in the effectiveness of generic exercise plans. This heterogeneity in response to different exercise interventions highlights the need for more personalized approaches, tailoring exercise plans to individual patient profiles to optimize therapeutic outcomes. Our study addresses this critical need through the development of the T2DFitTailor package, a novel R-based tool that customizes exercise recommendations for T2D patients. Utilizing a comprehensive analysis of individual parameters, T2DFitTailor accurately predicts the impact of specific exercise plans on the reduction of glycated hemoglobin (HbA1c) levels. This personalized approach to exercise prescription in T2D management is a significant step forward in optimizing treatment strategies. It allows for a more targeted, effective intervention, thereby improving patient outcomes and quality of life. T2DFitTailor, accessible at ‘https://cran.r-project.org/package=T2DFitTailor’, represents a notable contribution to T2D care, reflecting the ongoing shift towards more data-driven and personalized healthcare strategies. This tool provides a practical solution to meet the varied requirements of T2D patients, ensuring that exercise prescriptions are not only based on scientific evidence but also customized to suit individual health profiles and specific needs.
Coronary Microvascular Function Following Severe Preeclampsia
Authors: Honigberg Michael C. , Economy Katherine E. , Pabón Maria A. , Wang Xiaowen , Castro Claire , Brown Jenifer M. , Divakaran Sanjay , Weber Brittany N. , Barrett Leanne , Perillo Anna , Sun Anina Y. , Antoine Tajmara , Farrohi Faranak , Docktor Brenda , Lau Emily S. , DeFaria Yeh Doreen , Natarajan Pradeep , Sarma Amy A. , Weisbrod Robert M. , Hamburg Naomi M. , Ho Jennifer E. , Roh Jason D. , Wood Malissa J. , Scott Nandita S. , Di Carli Marcelo F. 
Published: March 2024

AbstractBackgroundPreeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating pro- and anti-angiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia-associated cardiovascular risk.MethodsWomen with singleton pregnancies complicated by severe antepartum-onset preeclampsia and a comparator group with normotensive deliveries underwent cardiac positron emission tomography (PET) within 4 weeks of delivery. A control group of pre-menopausal, non-postpartum women was also included. Myocardial flow reserve (MFR), myocardial blood flow (MBF), and coronary vascular resistance (CVR) were compared across groups. Soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) were measured at imaging.ResultsThe primary cohort included 19 women with severe preeclampsia (imaged at a mean 16.0 days postpartum), 5 with normotensive pregnancy (mean 14.4 days postpartum), and 13 non-postpartum female controls. Preeclampsia was associated with lower MFR (β=-0.67 [95% CI −1.21 to −0.13];P=0.016), lower stress MBF (β=-0.68 [95% CI, −1.07 to −0.29] mL/min/g;P=0.001), and higher stress CVR (β=+12.4 [95% CI 6.0 to 18.7] mmHg/mL/min/g;P=0.001) vs. non-postpartum controls. MFR and CVR after normotensive pregnancy were intermediate between preeclamptic and non-postpartum groups. Following preeclampsia, MFR was positively associated with time following delivery (P=0.008). The sFlt-1/PlGF ratio strongly correlated with rest MBF (r=0.71;P<0.001), independent of hemodynamics.ConclusionsIn this exploratory study, we observed reduced coronary microvascular function in the early postpartum period following severe preeclampsia, suggesting that systemic microvascular dysfunction in preeclampsia involves the coronary microcirculation. Further research is needed to establish interventions to mitigate risk of preeclampsia-associated cardiovascular disease.
Addressing anemia severity in antimony-resistantLeishmania donovaniinfection at the nexus of oxidative outburst and iron transit
Authors: Ghosh Souradeepa , Chigicherla Krishna Vamshi , Dasgupta Shirin , Goto Yasuyuki , Mukherjee Budhaditya 
Published: March 2024

AbstractDespite the withdrawal of pentavalent-antimonials in treating Visceral leishmaniasis for more than a decade, recent clinical isolates ofLeishmania donovani(LD) exhibit unresponsiveness towards pentavalent-antimony (LD-R). This antimony-unresponsiveness points towards a genetic adaptation that underpins LD-R’s evolutionary persistence and superiority over sensitive counterparts. This study highlights LD’s response to antimony exposure in terms of increased potential of scavenging host-derived iron within its parasitophorous vacuoles (PV). LD-R employs a strategy to both produce and rapidly scavenge host-iron in a ROS-dependant manner, and selectively reshuffle iron exporter, Ferroportin, around its PV. Higher iron utilization leads to subsequent iron-insufficiency, compensated by increased erythrophagocytosis facilitated by the breakdown of SIRPα, orchestrated by a complex interplay of two proteases, Furin and ADAM10. Understanding these mechanisms is crucial for managing LD-R infections and their associated complications, like anemia, and may also provide valuable insights into understanding resistance developed in other pathogens that rely on host iron.
Does owners’ leadership matter to relational behavior in mega construction projects? A role orientation perspective
Authors: Zheng Xian , Hu Xiao , Wu Chunlin , Bai Ju 
Published: March 2024

PurposeAlthough researchers have long recognized the importance of participating organizations’ (POs) relational behavior for mega construction projects (MCPs) performance, relational behavior may not be executed by POs without effective leadership from project owners. However, little is known about the mechanisms linking owners’ leadership styles to POs’ relational behavior. This study draws on full range leadership theory and role theory to examine the relationships between owners’ leadership styles (i.e. transformational and transactional) and relational behavior. POs’ role orientations (i.e. normative and economic) are considered as potential mediators.Design/methodology/approachData were collected from 175 managers deeply involved in MCPs. Hierarchical regression model and bootstrapping methods were performed on the data to examine the direct effects of owners’ leadership on POs’ relational behavior and the mediating effects of POs’ role orientations.FindingsThe results revealed that both owners’ transformational and transactional leadership positively affect POs’ relational behavior, despite the former being higher than the latter, and indirectly influence relational behavior via POs’ normative and economic role orientation, respectively.Practical implicationsThis study provides a clear picture of how owners’ leadership can motivate POs’ relational behavior to achieve high-quality inter-organizational relationships in MCPs. The findings can guide owners’ top manager selection by prioritizing those with transformational leadership, which is beneficial to achieving high-level relational behavior of POs. The results also imply that owners should pay greater attention to cultivating POs’ normative role orientation by encouraging teamwork and open communication to enhance their implementation of relational behavior.Originality/valueUnlike previous research focusing more on intra-organizational leader–follower relationship within one PO, this study is one of the first to empirically confirm owners’ leadership as a critical antecedent of POs’ relational behavior, thus enhancing the theoretical understanding of inter-organizational relationship management in MCPs. Based on role theory, this study considers a novel organizational psychology mechanism, i.e. POs’ role orientations, as the mediator to unravel how owners’ leadership affects POs’ relational behavior, which was rarely invoked in MCP leadership literature.
The effect of fabric structure on the pilling and abrasion resistance of interlock weft-knitted fabrics
Authors: Asayesh Azita , Kolahi Mahmoodi Fatemeh 
Published: March 2024

PurposePilling and abrasion resistance are two of the most important mechanical properties of the fabric that influence the appearance and performance of the fabric, particularly in the case of knitted fabrics. Since, these fabric features are affected by fabric structure the aim of present research is to investigate how utilizing miss stitches and tuck stitches in the fabric structure for design purposes will influence the pilling and abrasion resistance of interlock weft-knitted fabrics.Design/methodology/approachIn this research, interlock fabrics with different number of miss or tuck stitches on successive Wales were produced and pilling performance and abrasion resistance of the fabrics were investigated.FindingsThe results revealed that increasing the number of miss/tuck stitches on successive Wales decreases the abrasion resistance and enhances the pilling tendency of the fabric. The presence of miss/tuck stitches on both sides of the fabric improves the abrasion resistance and pilling performance of the fabric compared to fabrics containing these stitches on one side of the fabric. Furthermore, the fabric resistance against abrasion and pilling is higher in fabrics consisting of miss stitches compared to fabrics consisting of tuck stitches.Originality/valueThe use of tuck and miss stitches in designing the weft-knitted fabrics is a common method for producing fabrics with variety of knit patterns. Since pilling and abrasion resistance of the fabric influence on its appearance and performance, and none of the previous research studied the pilling and abrasion resistance of interlock-knitted fabrics from the point of presence of tuck and miss stitches on successive Wales of the fabric, this subject has been surveyed in the present research.
Integrating the bright and dark sides of temporal leadership on employees’ thriving at work
Authors: Wang Hui , Zhang Han , Zhu Jian 
Published: March 2024

PurposeDrawing on conservation of resources theory, this study aims to examine the relationship between temporal leadership (TL) and employees’ thriving at work (TW) by focusing on the positive mediating role of perception of work-goal progress (PWP), the negative mediating roles of job-based psychological ownership (JPO) and the moderating role of synchrony preference (SP).Design/methodology/approachWe employed a dedicated data collection platform called Credamo for two waves of online questionnaires in China between March 2022 and April 2022. A total of 326 questionnaires were collected and analyzed to test the hypotheses.Findings(1) TL directly and positively affects TW. (2) TL indirectly and positively affects TW via PWP. (3) TL indirectly and negatively affects TW via JPO. (4) SP positively moderates the positive mediating effect of PWP on the relationship between TL and TW. (5) SP negatively moderates the negative mediating effect of JPO on the relationship between TL and TW.Practical implicationsSupervisors in organizations ought to discreetly practice TL and try to maximize the positive role of PWP and minimize the negative role of JPO.Originality/valueThe findings simultaneously discuss the effects of TL on TW from dark and bright perspectives. The influence of interaction between contextual and individual features on TW is also specified.
Does institutional quality moderate the human capital–inequality dynamics? Comparative evidence from LAC and SSA countries
Authors: Adeleye Bosede Ngozi 
Published: March 2024

AbstractAligning with Sustainable Development Goal 10, this study probes whether quality institutions matter in the drive towards reducing income inequality through human capital. An unbalanced panel data on the Gini index (measure of income inequality), human capital index and institutional quality index drawn across 83 Latin America and sub‐Saharan African (SSA) countries from 2010 to 2019 is used. For the most part, the consensus is that the interaction of human capital and quality institutions significantly reduces income inequality. For context, inequality reduces by −7.810 and −21.30 points for the full and SSA samples. Other findings reveal that the interaction effect is consistently negative at upper quantiles. Evidence from the margin plots reveals that the effect of human capital on inequality improves as institutional quality is strengthened. The downward trend of the plot within the 95% confidence interval shows that institutional quality enhances the impact of human capital on income inequality for the full sample and in SSA. This is a novel contribution to the literature as it suggests that quality institutions matter in the drive towards reducing the menace of income inequality. Policy recommendations are discussed.
Application of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage in primary intravaginal anejaculation
Authors: Gao Qingqiang , Chen Jianhuai , Wang Bin , Hang Youfeng , Gao Songzhan , Yang Jie , Dai Yutian 
Published: March 2024

AbstractIntroductionPrimary intravaginal anejaculation (PIAJ) is a relatively uncommon male sexual dysfunction characterized by an inability to achieve intravaginal ejaculation during all sexual intercourse. Effective treatment options for this condition are lacking. We aimed to explore the clinical effect of the sexual therapy combined with vacuum negative pressure hydropneumatic/pneumatic bubble massage (VNPHP/PBM) on primary intravaginal anejaculation, and its possible mechanism.MethodsA total of 95 PIAJ patients were randomly divided into three groups, including group A with 32 patients treated with the sexual therapy combined with VNPHP/PBM, group B with 32 patients treated with the sexual therapy and group C with 31 patients treated with VNPHP/PBM. The efficacy of therapeutic regimes, latency of the somatosensory evoked potentials of dorsal nerve (DNSEP), glans penis (GPSEP) and penile shaft sensory threshold (PSST), measures of sexual behavior of patients, as well as the self‐rating anxiety scale (SAS) sores of patients and their partners, were compared before and after treatment among three groups.ResultsThe total effective rate of group A (84.38%) was higher than those of groups B and C (53.13% and 41.94%), however, no differences were found between groups B and C. The ratios of patients and their partners with anxiety, frequency of observing erotic films of patients, ratios of patients with special self‐masturbation and frequency of masturbation decreased significantly in the three groups after the treatment. The decrease in the ratios of patients and their partners with anxiety, frequency of observing erotic films of patients in groups A and B were higher than those of group C, however, no differences were identified between groups A and B. The decrease in the ratios of patients with special self‐masturbation and frequency of masturbation in group A were higher than those of group B, however, no differences were found between groups A and C, B and C. There were no differences in the latency of DNSEP, GPSEP, and PSST among the three groups before and after treatment.ConclusionThe sexual therapy combined with VNPHP/PBM has good therapeutic effects on PIAJ, which might be achieved by reducing the anxiety level of patients and their partners, improving sexual behavioral patterns, rather than increasing the sensitivity of penis including dorsal nerve and glans penis.
A case of lethal suicidal intoxication with propafenone and diazepam
Authors: Yan Shuangbing , Xin Ting , Luo Xiaojie , Wang Yu , Chen Bingwei 
Published: March 2024

AbstractDiazepam poisoning is a common emergency situation, but propafenone poisoning is relatively rare. We reported a case of propafenone poisoning combined with diazepam. An 18‐year‐old female patient was admitted to our hospital with an overdose of oral propafenone and diazepam. The patient was treated with medication that proved to be useful, but the sinus rhythm could not be recovered, and cardiac arrest occurred. A bipolar temporary pacemaker and extracorporeal membrane oxygenation (ECMO) were installed. However, even with multiple electrode positions, effective capture could not be achieved. The patient eventually died. We should be alert to the possibility of co‐poisoning.
Parental differential treatment of siblings linked with internalizing and externalizing behavior: A meta‐analysis
Authors: Jensen Alexander C. , Thomsen Alexandra E. 
Published: March 2024

AbstractThis meta‐analysis linked relative and absolute parental differential treatment (PDT) with internalizing and externalizing behavior of children and adolescents. Multilevel meta‐analysis data represented 26,451 participants based on 2890 effect sizes coming from 88 sources, nested within 43 samples. Participants were between 3.18 and 18.99 years of age (Mage = 12.64, SD = 3.89; 51.31% female; 82.23% White; 54.68% from the United States). Less‐favored treatment (relative PDT) was linked to more internalizing and externalizing behavior. Additionally, greater differences in parenting between siblings (absolute PDT) were linked to more internalizing and externalizing behavior. Some links were moderated by other factors. For example, some effects were stronger when PDT was reported by children, and others, when siblings were closer in age.
Genebe.net: Implementation and validation of an automatic ACMG variant pathogenicity criteria assignment
Authors: Stawiński Piotr , Płoski Rafał 
Published: March 2024

AbstractWe present GeneBe, an online platform streamlining the automated application of American College of Medical Genetics and Genomics (ACMG), Association for Molecular Pathology (AMP), and the College of American Pathologists (CAP) criteria for assessment of pathogenicity of genetic variants. GeneBe utilizes automated algorithms that evaluate 17 criteria from 28, closely aligning with current guidelines and leveraging data from diverse sources, including ClinVar. The user‐friendly web interface enables manual refinement of assignments for specific criteria based on site‐collected data. Our algorithm demonstrates a high correlation (r = 0.90) of assigned pathogenicity scores compared to expert assessments from the ClinGen Evidence Repository and substantial concordance with ClinVar verdict assignments (κ = 0.69). Comparative analysis with other published tools reveals that GeneBe performs similarly to VarSome while being superior over TAPES and InterVar. In contrast to some other tools, GeneBe's web implementation is tracker‐free and third‐party request‐free, safeguarding user privacy. Additionally, GeneBe offers an Application Programming Interface (API) for enhanced flexibility and integration into existing workflows and is provided free of charge for research purposes. GeneBe is available at https://genebe.net.