bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and parametric analysis of a novel hybrid thermal management strategy for cylindrical lithium‐ion cells
Authors: Shahid Seham , Agelin‐Chaab Martin 
Published: April 2024

AbstractThis paper reports on a novel hybrid thermal management strategy. It uses secondary coolants (air and liquid) to withdraw heat simultaneously from the composite phase change material, resulting in increased heat extraction capability of the composite phase change material and improved thermal environment of the battery module. The significance of this strategy is that the fluid used in the liquid cooling stays stationary. Comprehensive experimental and numerical studies are performed, and parametric studies are conducted to reduce the volume of the phase change material, size of the air duct, and airflow Reynolds number. The numerical results showed that the maximum temperature was limited to 27.8°C, and a high‐temperature uniformity of 0.4°C was obtained. Furthermore, the required volume of the composite phase change material is reduced by ~50%. Additionally, beyond a 6 mm height of the air duct, the reduction in maximum pressure drop is not significant enough, and it is considered the optimal height, and a Reynolds number of 1950 is considered the optimal airflow Reynolds number. Therefore, the proposed thermal management concept for the battery module can sustain the thermal environment needed for the effective operation of Lithium‐ion batteries.
Does Tri‐Staple™ technology reduce the risk of anastomotic leakage in colorectal surgery? A propensity score matching analysis
Authors: Gerbasi Lucas Soares , Tustumi Francisco , Seid Victor Edmond , Araujo Sergio Eduardo Alonso 
Published: April 2024

AbstractBackground and ObjectivesThis study evaluates the Tri‐Staple™ technology in colorectal anastomosis.MethodsPatients who underwent rectosigmoidectomy between 2016 and 2022 were retrospectively evaluated and divided into two groups: EEA™ (EEA) or Tri‐Staple™ (Tri‐EEA). The groups were matched for age, sex, American Society of Anesthesiologists (ASA), and neoadjuvant radiotherapy using propensity score matching (PSM).ResultThree hundred and thirty‐six patients were included (228 EEA; 108 Tri‐EEA). The groups were similar in sex, age, and neoadjuvant therapy. The Tri‐EEA group had fewer patients with ASA III/IV scores (7% vs. 33%; p < 0.001). The Tri‐EEA group had a lower incidence of leakage (4% vs. 11%; p = 0.023), reoperations (4% vs. 12%; p = 0.016), and severe complications (6% vs. 14%; p = 0.026). There was no difference in complications, mortality, readmission, and length of stay. After PSM, 108 patients in the EEA group were compared with 108 in the Tri‐EEA group. The covariates sex, age, neoadjuvant radiotherapy, and ASA were balanced, and the risk of leakage (4% vs. 12%; p = 0.04), reoperation (4% vs. 14%; p = 0.014), and severe complications (6% vs. 15%; p = 0.041) remained lower in the Tri‐EEA group.ConclusionTri‐Staple™ reduces the risk of leakage in colorectal anastomosis. However, this study provides only insights, and further research is warranted to confirm these findings.
Post‐tuberculosis respiratory impairment in Gambian children and adolescents: A cross‐sectional analysis
Authors: Nkereuwem Esin , Agbla Schadrac , Njai Bintou , Edem Victory Fabian , Jatta Muhammed Lamin , Owolabi Olumuyiwa , Masterton Uma , Jah Fatoumatta , Danso Madikoi , Fofana Aunty Nyima , Samateh Wandifa , Darboe Muhammed Lamin , Owusu Sheila Ageiwaa , Bush Andrew , Kampmann Beate , Togun Toyin 
Published: April 2024

AbstractBackgroundAlthough post‐tuberculosis lung disease (PTLD) is a known consequence of pulmonary tuberculosis (pTB), few studies have reported the prevalence and spectrum of PTLD in children and adolescents.MethodsChildren and adolescent (≤19 years) survivors of pTB in the Western Regions of The Gambia underwent a respiratory symptom screening, chest X‐ray (CXR) and spirometry at TB treatment completion. Variables associated with lung function impairment were identified through logistic regression models.ResultsBetween March 2022 and July 2023, 79 participants were recruited. The median age was 15.6 years (IQR: 11.8, 17.9); the majority, 53/79 (67.1%), were treated for bacteriologically confirmed pTB, and 8/79 (10.1%) were children and adolescents living with HIV. At pTB treatment completion, 28/79 (35.4%) reported respiratory symptoms, 37/78 (47.4%) had radiological sequelae, and 45/79 (57.0%) had abnormal spirometry. The most common respiratory sequelae were cough (21/79, 26.6%), fibrosis on CXR (22/78, 28.2%), and restrictive spirometry (41/79, 51.9%). Age at TB diagnosis over ten years, undernutrition and fibrosis on CXR at treatment completion were significantly associated with abnormal spirometry (p = .050, .004, and .038, respectively).ConclusionChronic respiratory symptoms, abnormal CXR, and impaired lung function are common and under‐reported consequences of pTB in children and adolescents. Post‐TB evaluation and monitoring may be necessary to improve patient outcomes.
Estimating bacterial breakthrough behaviors based on bacterial retention profiles in porous media
Authors: Chen Fengxian , Yang Liqiong , Chen Xijuan , Zhuang Jie 
Published: April 2024

AbstractTraditional methods for assessing bacterial transport in soil or permeable sand aquifers, such as flow‐through experiments, breakthrough curve (BTC), and retention profile (RP) analysis, face challenges due to their complexity and the labor‐intensive nature of in situ implementations. This study seeks to address the question: How can the transport behavior of bacteria in soil be predicted in a simpler and more cost‐effective manner using RPs? We introduce an RP method designed to overcome these challenges by utilizing soil sampling at various depths to model bacterial breakthrough behaviors with greater efficiency. By employing the one‐site attachment/detachment model within the Hydrus 1D framework, our research compares the RP method (three RPs) against the conventional approach (BTC + RP), showcasing its efficacy through column experiments with bioluminescent Escherichia coli in humic acid‐coated sand. The results indicate that the accuracy of RP method aligns closely with traditional methods in predicting bacterial transport. This technique allows for the use of solid samples collected from a limited number of depths to predict breakthrough behaviors accurately, making it suitable for evaluating bacterial transport in settings such as farmlands, contaminated lands, riverbanks, and soil aquifer treatment systems. Our findings underscore the RP method's role in streamlining experimental procedures and its potential application in environmental science and agronomy.
Anti‐Coronavirus Activity of Certain Herbacetin Derivatives, A Theoretical Study
Authors: Rafiee Marjan A. 
Published: April 2024

AbstractFlavonoids are natural products commonly found in the human diet with anti‐viral activity. The electrochemical activity of flavonoids is effective in their inhibitory properties. Herbacetin is an anti‐coronavirus drug from the flavonoid family. To understand structure‐electrochemical activity relations, ab initio calculations on some selected herbacetin derivatives were carried out using Gaussian 09 in B3LYP/6‐311G*. The effect of the position and type of the various substituents in the ring A of the flavone backbone are considered. The oxygen charge density of the hydroxyl group on C8 (O8) in the considered herbacetins was compared using nuclear quadrupole coupling constants (NQCC) calculations. Results showed that the presence of the amino group in the ortho position of O8 has the most significant effect on increasing the charge density of the O8 atom (O8‐NQCC=9.23 MHz). Based on the proposed mechanism of these drugs, ortho‐amino herbacetin is expected to show a significant anti‐coronavirus effect. Comparison of calculated O8‐NQCCs of tangeretin and nobiletin with herbacetin shows that with the replacement of OH with OCH3, the charge density of oxygen atoms decreases (about 2 MHz). Therefore tangeretin and nobiletin have a lower drug effect than herbacetin. Natural bond orbital (NBO) results are in agreement with calculated NQCCs.
Highly Versatile, Non‐noble Metal‐Based Catalytic Process for the Production of Green Aromatics and High‐Octane Fuel from Bio‐Derived Hydrocarbon Mix
Authors: Kumar Mahesh , Prakash Tathod Anup , Singh Vijendra , Arumugam Selvamani , Viswanadham Nagabhatla 
Published: April 2024

AbstractThe present work deals with the value‐addition to bio‐derived hydrocarbon mix obtained as a side product in biorefinery for petrochemicals and fuel applications. One aspect of this study focused on developing a highly versatile, non‐noble metal‐based catalytic process to facilitate the production of green aromatics and high‐octane fuel from a renewable bio‐derived hydrocarbon mix. Considering the availability of various conventional/unconventional feedstocks viz. industrial petroleum naphtha and crude‐derived hydrocarbon mix, the catalyst development is also expanded for effective conversion of such feedstocks to produce aromatics. For this, a detailed understanding of the catalyst property‐activity relationship has been established with the help of characterization techniques like FTIR, XRD, NH3‐TPD, Pyridine‐IR, N2 adsorption‐desorption, HR‐TEM, XPS, TGA, etc. The studies revealed promising catalytic activity of 5Zn‐2Ga‐0.5Ba/H‐ZSM‐5 to exhibit very high aromatic selectivity (up to 80 %) and high‐octane fuel production (>100 RON) from all the feedstocks possessing different hydrocarbon composition. The catalyst showed good repeatability and recyclability at the tested reaction conditions.
Adsorption of Coomassie Brilliant Blue on a Novel Eco‐Friendly Nanogel from Simulated Water: Equilibrium, Kinetic, and Thermodynamic Studies
Authors: Khan Suhail Ayoub , Manchanda Ankita , Khan Tabrez Alam 
Published: April 2024

AbstractHerein a novel gum acacia‐alginate nanogel (GAA) was synthesized via ultrasound‐assisted crosslinking by DPPH and applied for the removal of coomassie brilliant blue (CBB) dye. The fabrication of GAA and its interaction with CBB was specified via FTIR, XRD, SEM, and TEM techniques. The process parameters at which maximum adsorption efficiency, qe (80.12 mg/g), and % efficiency >94 % were achieved include dosage (0.8 g/L), time (80 min), initial dye concentration (20 mg/L), and pH (6). Ultrasound‐assisted uptake was greater than stirring‐assisted due to acoustic cavitation′s hydrodynamic and thermal processes. Pseudo‐second‐order model described the adsorption kinetics and the diffusion mechanism suggested that the rate‐determining step was controlled by both the intraparticle diffusion and the liquid film models. Isotherms showed an excellent fit to the Freundlich model based on higher R2 (0.998) and lower standard error of estimate values (SEE=0.367). The −ΔG° values (−8.152, −8.292, −8.433, −8.586 kJ/mol) indicated that the adsorption process was feasible and spontaneous. The removal of CBB ensued via hydrogen bonding, electrostatic, π‐π, and n‐π interactions. The maximum adsorption capacity of 182.096 mg/g, eco‐friendly characteristics along with regeneration competence depicted that GAA could be effective for scavenging CBB from wastewater.
Photocatalytic Degradation of Maxilon Dye Pollutants using Nano‐Architecture Functional Materials: A Review
Authors: Emmanuel Stephen Sunday , Adesibikan Ademidun Adeola , Olawoyin Christopher Olusola , Idris Mustapha Omenesa 
Published: April 2024

AbstractThe most essential task in the twenty‐first century is to fight the alarming growing pollution in the aquatic body in which effluent of one of the most colouring dye categories called maxilon dye is a major contributor. This review thus specifically focuses on the use of nanoparticles (NPs) for photocatalytic degradation of maxilon dye contaminants in water bodies. The work empirically presented the performance evaluation of NPs in degrading maxilon dyes under light irradiation alongside the underlying operational photocatalytic degradation mechanism. The stability of NPs was also critically analyzed by looking at the regenerability and reusability of expended NPs. From the study, it was discovered that ⋅OH and O2⋅ played a vital role in the genesis of the oxidizing capacity of NPs for the photocatalytic breakdown of maxilon dye. Moreover, it was found that the degradation performance of most NPs is greater than 80 % and the shortest degradation period is < 1 hour with pseudo‐first‐order (PFO) being the most common kinetic best‐fit to describe the adsorption process that occurred shortly before and during the degradation operation. At the end, knowledge gaps were identified in the area of regenerability, the lifecycle analyses of nano‐photocatalyst fabrication and utilization, cost analysis for industrial scale‐up, maxilon dye ecotoxicological study, and degradation pathways. The findings of this study can open up insightful innovation for readers and industries that are interested in pursuing zero water insecurity.
Temperature/GSH Dual Responsive Fluorinated Mesoporous Silica‐Coated Au NRs for Serum‐Resistant Gene Delivery**
Authors: Sun Weitao , Fu Chunhua , Zhang Zhongyu , Sun Wan 
Published: April 2024

AbstractMesoporous silica nanoparticles (MSN) are emerging as one of the most appealing candidates for gene carriers. Nevertheless, one major obstacle for their clinical application is the lack of efficient controlled release and gene delivery. In this study, a mesoporous silica‐modified gold nanorods (Au NRs) controlled release platform was synthesized. Then a thermosensitive copolymer was grafted to the surface of release platform, to impart the switching response of carrier under the photothermal of Au NRs. Fluorination were modified on the surface of MSN through a disulfide bond to achieve glutathione (GSH) response release and improve serum‐resistant ability. This gene carrier, with notable DNA condensation ability and negligible cytotoxicity, could be easily internalized into cells, enhanced green fluorescent protein expression in the presence of serum under laser irradiation. This work inspired us to solve the problem of traditional controllable sustained release and realize the performance of intracellular switch response to gene sustained release.
Prospect of Controlled Autoxidation to Produce High‐Value Products from the Low‐Value Petroleum Fractions
Authors: Siddiquee Muhammad N. 
Published: April 2024

AbstractSubstantial amounts of low‐value light petroleum fractions and low‐value heavy petroleum fractions, such as light naphtha, HVGO, and vacuum residue, are generated during the upgrading and refining of conventional and unconventional petroleum resources. The oil industry emphasizes economic diversification, aiming to produce high‐value products from these low petroleum fractions through cost‐effective and sustainable methods. Controlled autoxidation (oxidation with air) has the potential to produce industrially important oxygenates, including alcohols, and ketones, from the low‐value light petroleum fractions. The produced alcohols can also be converted to olefin through catalytic dehydration. Following controlled autoxidation, the low‐value heavy petroleum fractions can be utilized to produce value‐added products, including carbon fiber precursors. It would reduce the production cost of a highly demandable product, carbon fiber. This review highlights the prospect of developing an alternative, sustainable, and economic method to produce value‐added products from the low‐value petroleum fractions following a controlled autoxidation approach.
Gauged permutation invariant matrix quantum mechanics: path integrals
Authors: O’Connor Denjoe , Ramgoolam Sanjaye 
Published: April 2024

AbstractWe give a path integral construction of the quantum mechanical partition function for gauged finite groups. Our construction gives the quantization of a system ofd,N × Nmatrices invariant under the adjoint action of the symmetric groupSN. The approach is general to any discrete group. For a system of harmonic oscillators, i.e. for the non-interacting case, the partition function is given by the Molien-Weyl formula times the zero-point energy contribution. We further generalise the result to a system of non-square and complex matrices transforming under arbitrary representations of the gauge group.
TLR5 agonist in combination with anti-PD-1 treatment enhances anti-tumor effect through M1/M2 macrophage polarization shift and CD8+ T cell priming
Authors: Lee Junseok , Im Keon-Il , Gil Sojin , Na Hyemin , Min Gi-June , Kim Nayoun , Cho Seok-Goo 
Published: April 2024

AbstractImmune checkpoint inhibitors have revolutionized anti-tumor therapy, notably improving treatment responses in various tumors. However, many patients remain non-responsive and do not experience benefits. Given that Toll-like receptors (TLRs) can counteract tumor immune tolerance by stimulating both innate and adaptive immune responses, TLR agonists are being explored as potential immune adjuvants for cancer treatment. In this study, we assessed the potential of enhancing the efficacy of immune checkpoint inhibitors by activating innate immunity with a TLR5 agonist. In a mouse tumor model, combination therapy with TLR5 agonist and anti-PD-1 significantly inhibited tumor growth. The TLR5 agonist shifted the balance from M2-like to M1-like macrophages and upregulated the expression of co-stimulatory molecules in macrophages. Furthermore, TLR5 agonist promoted the activation and tumor infiltration of CD8+ T cells. As a result, the TLR5 agonist augmented the anti-tumor efficacy of anti-PD-1, suggesting its potential in modulating the tumor microenvironment to enhance the anti-tumor response. Our findings point toward the possibility of optimizing immune checkpoint inhibitor therapy using TLR5 agonists.
Antioxidant supplementation may effect DNA methylation patterns, apoptosis, and ROS levels in developing mouse embryos
Authors: Uysal Fatma , Sukur Gozde , Bozdemir Nazlican , Cinar Ozgur 
Published: April 2024

AbstractThis study was designed to address the question: does antioxidant-containing embryo culture media affect DNA methyltransferases, global DNA methylation, inner cell mass/trophoblast differentiation, intracellular reactive oxygen species (ROS) levels, and apoptosis? Mouse zygotes were cultured in embryo culture media containing MitoQ, N-acetyl-l-cysteine (NAC), acetyl-l-carnitine (ALC), α-lipoic acid (ALA), or the mixture of NAC + ALC + ALA (AO) until the blastocyst stage, whereas in vivo-developed blastocysts were used as control. Protein expression levels of Dnmt1, 3a, 3b, and 3l enzymes were analyzed by immunofluorescence and western blot, while global DNA methylation, apoptosis, and ROS levels were evaluated by immunofluorescence. NAC, ALC, and MitoQ significantly increased the levels of all Dnmts and global methylation. ALA significantly induced all Dnmts, whereas global methylation did not show any difference. NAC and mixture AO applications significantly induced Nanog levels, ALA and MitoQ increased Cdx2 levels, while the other groups were similar. ALA and MitoQ decreased while ALC increased the levels of intracellular ROS. This study illustrates that antioxidants, operating through distinct pathways, have varying impacts on DNA methylation levels and cell differentiation in mouse embryos. Further investigations are warranted to assess the implications of these alterations on the subsequent offspring.
Pancreatic head resection for carcinoma of the ampulla vateri – better long-term prognosis, but more postoperative complications
Authors: Kuesters Simon , Sundheimer Johanna , Wittel Uwe A. , Chikhladze Sophia , Fichtner-Feigl Stefan , Biesel Esther A. 
Published: April 2024

Abstract
Background
Pancreatoduodenectomies are complex surgical procedures with a considerable morbidity and mortality even in high-volume centers. However, postoperative morbidity and long-term oncological outcome are not only affected by the surgical procedure itself, but also by the underlying disease. The aim of our study is an analysis of pancreatoduodenectomies for patients with pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (CAMP) concerning postoperative complications and long-term outcome in a tertiary hospital in Germany.

Methods
The perioperative and oncological outcome of 109 pancreatic head resections performed for carcinoma of the ampulla vateri was compared to the outcome of 518 pancreatic head resections for pancreatic ductal adenocarcinoma over a 20 year-period from January 2002 until December 2021. All operative procedures were performed at the University Hospital Freiburg, Germany. Patient data was analyzed retrospectively, using a prospectively maintained SPSS database. Propensity score matching was performed to adjust for differences in surgical and reconstruction technique. Primary outcome of our study was long-term overall survival, secondary outcomes were postoperative complications and 30-day postoperative mortality. Postoperative complications like pancreatic fistula (POPF), postpancreatectomy hemorrhage (PPH) and delayed gastric emptying (DGE) were graded following current international definitions. Survival was estimated using Kaplan Meier curves and log-rank tests. A p-value < 0.05 was considered statistically significant.

Results
Operation time was significantly longer in PDAC patients (432 vs. 391 min, p < 0.001). The rate of portal vein resections was significantly higher in PDAC patients (p < 0.001). In CAMP patients, a pancreatogastrostomy as reconstruction technique was performed more frequently compared to PDAC patients (48.6% vs. 29.9%, p < 0.001) and there was a trend towards more laparoscopic surgeries in CAMP patients (p = 0.051). After propensity score matching, we found no difference in DGE B/C and PPH B/C (p = 0.389; p = 0.517), but a significantly higher rate of clinically relevant pancreatic fistula (CR-POPF) in patients with pancreatoduodenectomies due to ampullary carcinoma (30.7% vs. 16.8%, p < 0.001). Long-term survival was significantly better in CAMP patients (42 vs. 24 months, p = 0.003).

Conclusion
Patients with pancreatoduodenectomies due to ampullary carcinomas showed a better long-term oncological survival, by reason of the better prognosis of this tumor entity. However, these patients often needed a more elaborated postoperative treatment due to the higher rate of clinically relevant pancreatic fistula in this group.
Electricity generation and real oily wastewater treatment by Pseudomonas citronellolis 620C in a microbial fuel cell: pyocyanin production as electron shuttle
Authors: Varnava Constantina K. , Persianis Panagiotis , Ieropoulos Ioannis , Tsipa Argyro 
Published: April 2024

AbstractIn the present study, the potential of Pseudomonas citronellolis 620C strain was evaluated, for the first time, to generate electricity in a standard, double chamber microbial fuel cell (MFC), with oily wastewater (OW) being the fuel at 43.625 mg/L initial chemical oxygen demand (COD). Both electrochemical and physicochemical results suggested that this P. citronellolis strain utilized efficiently the OW substrate and generated electricity in the MFC setup reaching 0.05 mW/m2 maximum power. COD removal was remarkable reaching 83.6 ± 0.1%, while qualitative and quantitative gas chromatography/mass spectrometry (GC/MS) analysis of the OW total petroleum and polycyclic aromatic hydrocarbons, and fatty acids revealed high degradation capacity. It was also determined that P. citronellolis 620C produced pyocyanin as electron shuttle in the anodic MFC chamber. To the authors’ best knowledge, this is the first study showing (phenazine-based) pyocyanin production from a species other than P. aeruginosa and, also, the first time that P. citronellolis 620C has been shown to produce electricity in a MFC. The production of pyocyanin, in combination with the formation of biofilm in the MFC anode, as observed with scanning electron microscopy (SEM) analysis, makes this P. citronellolis strain an attractive and promising candidate for wider MFC applications.