bluuebunny/crossref_metadata_2025_split huggingface dataset:
The basal chordate amphioxus as a simple model for elucidating developmental mechanisms in vertebrates
Authors: Koop Demian , Holland Linda Z. 
Published: September 2008

AbstractThis review examines the basal chordate, amphioxus, as a simple model for providing insights into the development and evolution of the vertebrates, with which it shares many features, including a pharynx perforated with gill slits, a dorsal nerve cord, segmented muscles, and a notochord. Conversely, amphioxus is simpler than vertebrates in lacking neural crest and paired cephalic sensory organs. Amphioxus embryos are less derived than those of vertebrates, because it lacks large quantities of yolk and/or extra‐embryonic tissues. Embryogenesis involves only a simple folding of tissue layers. In addition, the amphioxus genome lacks the large‐scale gene duplications of vertebrates. However, in spite of the comparative simplicity of amphioxus, its developmental mechanisms are proving to be highly conserved with those of vertebrates. Thus, studies of amphioxus development can shed light on similar, but more complex, development of vertebrates. Such studies are especially interesting for their insights into the genetic basis of craniofacial birth defects in humans. Birth Defects Research (Part C) 84:175–187, 2008. © 2008 Wiley‐Liss, Inc.
Chicken embryo as a model for regenerative medicine
Authors: Coleman Cynthia M. 
Published: September 2008

AbstractAlthough the chick embryo, including its extraembryonic membranes, has long been used as a model for developmental biology, its potential as a model for the repair and regeneration of adult human tissues is often overlooked. The chick offers a well‐defined profile of intercellular and intracellular signaling pathways regulating the development of nearly every organ system in conjunction with great flexibility for chimeric and transgenic experiments. Depending upon the system of interest, the chick can either directly reflect the human condition, as in spinal cord repair or in chorioallantoic membrane wound healing, and therefore act as an in vivo model for repair, or mirror our aspired therapy as in limb generation or otic restoration and therefore act as our guide. With these unique opportunities, the chick embryo is certainly a model to be considered when aiming to develop a regenerative therapy for human applications. Birth Defects Research (Part C) 84:245–256, 2008. © 2008 Wiley‐Liss, Inc.
Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: A case report
Authors: Alsharif Mariam , Aslan Deniz L. , Jessurun Jose , Gulbahce H. Evin , Pambuccian Stefan E. 
Published: September 2008

AbstractA 42‐year‐old man presented with severe abdominal pain, constipation, and hematuria. The patient had a history of seminoma treated by chemotherapy followed by bilateral orchiectomy and retroperitoneal lymph node dissection 16 years earlier. A computed tomography (CT) scan showed a 8.0 × 6.0 × 5.0 cm mass in the retrovesical space, encompassing the left side of his proximal bladder, the prostate, and the rectum. A urine cytologic specimen showed loosely cohesive cell clusters composed of highly atypical large cells and occasional large, single cells with macronucleoli present in a background of mainly lymphocytes and histiocytes was diagnosed as recurrent seminoma. Prostate biopsies showed extensively necrotic seminoma with accompanying granulomatous reaction. The tumor cells were immunoreactive for c‐kit (CD117), placental‐like alkaline phosphatase (PLAP), D2‐40, and OCT4. To our knowledge, this is the second report on urine cytology of metastatic seminoma. Diagn. Cytopathol. 2008;36:734–738. © 2008 Wiley‐Liss, Inc.
Metastatic hepatocellular carcinoma with CD138 positivity: An unusual mimic of multiple myeloma?
Authors: Ramalingam Preetha , Adeagbo Bamidele , Bollag Ronie , Lee Jeffrey , Reid‐Nicholson Michelle 
Published: September 2008

AbstractCD138 is a monoclonal anti‐syndecan‐1 antibody that is often used to identify plasma cells in the bone marrow of patients with multiple myeloma (MM). Several carcinomas may also express CD138 including prostate, colon, renal cell, and hepatocellular carcinoma (HCC). We report a case of metastatic HCC that presented as a soft tissue mass on the back of a 67‐year‐old male. Based on the clinical and radiologic findings, MM was strongly suspected. In addition, fine‐needle aspiration biopsy (FNAB) of the mass revealed neoplastic cells that were positive for CD138, both by immunohistochemistry (IHC) and flow cytometry. The cytomorphologic features however did not support a diagnosis of MM, but were consistent with metastatic HCC. Our case highlights the potential problems that may arise by over‐reliance on IHC and flow cytometry. Careful morphologic assessment as well as clinical and radiologic correlation are very important when evaluating any CD138‐positive neoplasm. This approach should improve diagnostic accuracy and reduce the risk of erroneous interpretation of aberrant IHC results. In addition, we examined the expression of CD138 in known cases of HCC. Diagn. Cytopathol. 2008;36:742–748. © 2008 Wiley‐Liss, Inc.
Fine‐needle aspiration biopsy of metastatic malignant melanoma resembling a malignant peripheral nerve sheath tumor
Authors: Bardarov Svetoslav , Michael Claire W. , Lucas David , Pang Yijun , Pu Robert T. 
Published: September 2008

AbstractWe report a case of metastatic malignant melanoma resembling a malignant peripheral sheath tumor, which posed a significant diagnostic challenge. The patient is a 76‐year‐old male, who presented in the emergency room with bilateral chest pain exacerbated by inspiration. The pain was present for 3 week and was not exacerbated by physical exercise. The diagnostic workup revealed bilateral parenchymal pulmonary infiltrates. The CT‐scan guided fine‐needle aspiration and the core biopsies of the largest pulmonary lesion revealed high‐grade spindle cell neoplasm with individual cell apoptosis and necrosis. The immunohistochemical profile on the cell block showed that the cells are positive for Vimentin. The S‐100 stain showed only focal positivity. The immunohistochemical stains for HMB45, Melan A, pancytokeratin, and smooth muscle actin were negative. Five years ago the patient was diagnosed with melanoma on the back with Clark level of IV. The melanoma was excised with clear margins and sentinel lymph nodes were negative. Careful examination of patient's previous slides revealed an area of spindle cell melanoma adjacent to a nodular type melanoma. Based on the patient's previous history, current clinico‐pathologic presentation and immunohistochemical profile, the diagnosis of metastatic malignant melanoma resembling peripheral nerve sheath tumor was favored over the diagnosis of metastatic malignant spindle cell neoplasm of unknown primary site, which by itself is very rare clinical scenario. Diagn. Cytopathol. 2008;36:754–757. © 2008 Wiley‐Liss, Inc.
Liesegang rings in fine needle aspirate of breast cysts with predominance of apocrine cells: A study of 14 cases
Authors: Gupta Raj K. 
Published: September 2008

AbstractFine needle aspirate (FNA) from 14 cases (age range 17–84 years), with Liesegang rings (LR's) in breast cysts seen over a period of 26 years comprised the material of this study from more than 38,000 FNA's of the breast which had been done for a variety of breast lesions. In six of the 14 cases, the aspirate was obtained under ultrasound guidance whereas in the remaining cases it was collected from a palpable lesion. The aspiration was performed using a 22 gauge needle and the syringe and needle contents were washed in a cytology container with 30% ethyl alcohol in physiologic saline. The cytologic preparations from half of the sample were made on a 5 micron Schleicher and Schuell filter and stained by Papanicolaou method whereas from the remainder of the sample a cell block was made and sections cut, stained with hematoxylin‐eosin (H&E) and used for immunohistochemical study.Filter preparations and cell blocks revealed cyanophilic, spherical, ring‐like structures of various sizes and shape mostly with double walls, and striations with amorphous material in the lumen and under polarized light were nonrefractile. Seen also were several apocrine cells and some macrophages and the LR's were found to be negative on immunostains for EMA and CK, and a panel of other special stains (Table I). Since LR's can be mistaken for ova, larvae, or parasites, it is important to be aware of their potential presence in aspirate samples of breast cysts to avoid a misdiagnosis. The exact mechanism of formation of LR's is not fully understood and certain views as proposed are discussed in this presentation. Diagn. Cytopathol. 2008;36:701–704. © 2008 Wiley‐Liss, Inc.
Diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease) by fine needle aspiration cytology
Authors: Kumar Bipin , Karki Smriti , Paudyal Punam 
Published: September 2008

AbstractSinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease) is a rare benign disease of unknown etiology presenting with massive lymphadenopathy. We report four cases of this disease retrieved from the archives of cytopathology laboratory, BPKIHS, Dharan, Nepal, during the period of January 2002 to October 2007. The cytologic morphology revealed lymphocytes, plasma cells, and single to multinucleated histiocytes with well preserved lymphocytes in their cytoplasm (emperipolesis or lymphophagocytosis). It is concluded that FNAC is a useful and reliable tool for the diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai‐Dorfman disease) and biopsy can be avoided in these patients, thereby reducing patient inconvenience and health care cost. Diagn. Cytopathol. 2008;36:691–695. © 2008 Wiley‐Liss, Inc.
Cytological detection of lymphoma in Douglas aspirate
Authors: Ljubić Nives , Sučić Mirna , Vasilj Ankica , Lang Nada , Dominis Mara , Batinica Anita Grgurević , Jurković Ljiljanka , Šiftar Zoran 
Published: September 2008

AbstractExcept in primary effusion lymphoma (PEL), serous effusions with lymphomatous cells in non‐Hodgkin lymphoma (NHL) are not frequently seen as first manifestation of disease. In NHL lymphoplasmacytic lymphoma (LPL) the spleen, lymph nodes, and bone marrow are frequently sites of disease and this type of NHL is usually associated with a serum paraprotein of IgM type accompanied by the clinical syndrome of Waldenström macroglobulinemia. Our patient with NHL LPL type presented in this report had less frequently seen involvement of gastrointestinal tract and clinically was first manifested as effusion in Douglas space. Cytological evaluation as well immunoanalyses of effusion in such cases is essential, and various ancillary studies, because of differential diagnostic problems of lymphomas in serous effusions, first include reactive lymphocytoses and small round‐cell tumors (SRCT). In our patient, cytology of effusion revealed cytomorphologically atypical lymphomatous cells with plasmocytoid differentiation. Immunocytochemical and flow cytometry analysis confirmed lymphoid cell differentiation and pathohistological diagnosis of CD20+ LPL was set after pathohistological analysis of resected ileum. Diagn. Cytopathol. 2008;36:729–733. © 2008 Wiley‐Liss, Inc.
Syntheses, Structures and Reactivities of [CpTc(CO)3X]+ and [CpRe(CO)3X]+ (Eur. J. Inorg. Chem. 27/2008)
Authors: Zobi Fabio , Spingler Bernhard , Alberto Roger 
Published: September 2008

AbstractThe cover picture shows new aspects of [Cp*Re(CO)3Br]+ and [Cp*Tc(CO)3Br]+ chemistry. High‐yield preparation of these basic complexes (especially for 999Tc) enabled a comparative exploration of the respective chemistries in water and organic solvents. The Lewis acidic ReIII and TcIII centres activate the CO ligands for directed substitutions and nucleophilic attack. The reaction with CH3OH gave a methyl formate complex which reduced to [Cp*M(CO)3] under acidic conditions. IR spectroscopy and kinetic studies with 13C‐labelled formate revealed the source for CO in [Cp*Re(CO)3]. Shown are the different colours of homologous Re and Tc complexes against a background of the Zurich lake area. The reactivity of the title compounds with alcohols implies potential for targeted inorganic medicinal chemistry if the OH group is pendent to a (radio)pharmaceutical. Details are discussed in the article by R. Alberto et al. on p. 4205 ff. We thank Dr. F. Wild for designing this picture.
An efficient chemo‐ and stereoselective synthesis of enaminones and enaminoesters using (bromodimethyl)sulfonium bromide under solvent‐free conditions
Authors: Das Biswanath , Kanth Boddu Shashi , Majhi Anjoy , Reddy Kongara Ravinder 
Published: September 2008

Abstract(Bromodimethyl)sulfonium bromide has efficiently been employed for chemo‐ and stereoselective conversions of β‐dicarbonyl compounds into β‐enaminones and β‐enaminoesters by a treatment with amines at room temperature under solvent‐free conditions. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:630–633, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20477
Stereoselective synthesis of enantiopure cyclic α‐aminophosphonic acids: Direct observation of inversion at phosphorus in phosphonate ester silyldealkylation by bromotrimethylsilane
Authors: Alfonsov Vladimir A. , McKenna Charles E. , Bayandina Evgenia V. , Kashemirov Boris A. , Yarmieva Liliya N. , Punegova Lyudmila N. , Kataeva Olga N. 
Published: September 2008

AbstractThe paper describes a simple, direct synthesis of enantiopure cyclic α‐aminophosphonic acids on the basis of silyldealkylation and followed by hydrolysis of the parent diastereoisomeric cyclic 1,4,2‐oxazaphosphorines, which have been obtained by intramolecular stereospecific nucleophilic addition of phosphites to imines. In this approach, the high diastereoselectivity of the stereocontrolling penultimate step is preserved by conversion of the intermediate ester to the final phosphonic acid under very mild, nonracemizing conditions. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:575–582, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20480
An efficient and green method for the synthesis of N‐phosphoramino o‐hydroxylphenyl α‐aminophosphonic monoesters
Authors: Zhang Jianfeng , Wang Yadan , Cui Zhanwei , Wang Fei , Miao Zhiwei , Chen Ruyu 
Published: September 2008

AbstractAn efficient and green method to the synthesis of N‐protected o‐hydroxylphenyl α‐amino‐alkylphosphonic monoesters is described. It consists of the three‐component Mannich‐type reaction of phosphoramides, carbonyl compounds (aldehydes or ketones), and 2‐chlorobenzo[1,3,2] diox‐aphospholes under solvent‐free and catalyst‐free conditions, followed by hydrolysis. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:596–601, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20483
Synthesis and fungicidal activity of O‐alkyl O‐aryl O‐2‐(stearamido)ethyl phosphates
Authors: Han Liang , Gao Jian‐Rong , Li Zheng‐Ming 
Published: September 2008

AbstractN‐stearoylethanolamine (NAE18:0) was reacted with O‐alkyl O‐aryl chlorophosphate and a series of O‐alkyl O‐aryl O‐2‐(stearamido)ethyl phosphates were synthesized to explore their antifungal activity. Compared with parent NAE18:0, title compounds without substitution or with methyl substitution on a benzene ring exhibited improved antifungal activity. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:602–608, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20485
A novel stereoselective synthesis of (2Z)‐2‐arylsulfanylallylic alcohols by tin–lithium exchange of (E)‐α‐stannylvinyl sulfides
Authors: Xu Yaping , Hao Wenyan , Wang Dong , Cai Mingzhong 
Published: September 2008

AbstractTin–lithium exchange reaction of (E)‐α‐stannylvinyl sulfides 1 with n‐butyllithium gave (Z)‐α‐arylsulfanylvinyllithiums 2, which reacted with aldehydes or ketones 3 to afford stereoselectively (2Z)‐2‐arylsulfanylallylic alcohols 4 in good to high yields. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:639–643, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20487
Organotin(IV) esters of (E)‐3‐furanyl‐2‐phenyl‐2‐propenoic acid: Synthesis, investigation of the coordination modes by IR, multinuclear NMR (1H, 13C, 119Sn) and In Vitro biological studies
Authors: Sadiq‐ur‐Rehman  , Ali Saqib , Shahzadi Saira 
Published: September 2008

AbstractComplexes [Me2SnL2 (I), Me3SnL (II), Et2SnL2 (III), n‐Bu2SnL2 (IV), n‐Bu3SnL (V), n‐Oct2SnL2 (VI)], where L is (E)‐3‐furanyl‐2‐phenyl‐2‐propenoate, have been synthesized and structurally characterized by vibrational and NMR (1H, 13C and 119Sn) spectroscopic techniques in combination with mass spectrometric and elemental analyses. The IR data indicate that in both the di‐ and triorganotin(IV) carboxylates the ligand moiety COO acts as a bidentate group in the solid state. The 119Sn NMR spectroscopic data, 1J[119Sn,13C] and 2J[119Sn, 1H], coupling constants show a four‐coordinated environment around the tin atom in triorganotin(IV) and five‐coordinated in diorganotin(IV) carboxylates in noncoordinating solvents. The complexes have been screened against bacteria, fungi, and brine‐shrimp larvae to assess their biological activity. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:612–620, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20488
A new convenient way to synthesize 1,3,4‐thiadiazol‐2‐yl urea derivatives under microwave irradiation
Authors: Li Kejian , Chen Wenbin 
Published: September 2008

AbstractA simple and efficient method was developed for the synthesis of 1‐(substituted)‐3‐(5‐(substituted)‐1,3,4‐thiadiazol‐2‐yl) ureas from heterocyclic amino compounds and phenyl‐5‐(pyridine‐3‐yl)‐1,3,4‐thiadiazol‐2‐ylcarbamate(2) or phenyl‐5‐(trifluoro‐methyl)‐1,3,4‐thiadiazol‐2‐ylcarbamate(5) under solvent conditions using microwave irradiation. The products were obtained in satisfactory yield as we expected. The reactions can be realized by conventional heating, but we find that the condition of microwave is better according to the reaction time. New 1‐(substituted)‐3‐(5‐(substituted)‐1,3,4‐thiadiazol‐2‐yl) urea derivatives are reported. The products were characterized by1H NMR, ESI‐MS, and Elemental analysis. The crystal structure of compound6hwas determined by X‐ray single crystal diffraction. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:621–629, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20489
Bismuth‐catalyzed cyclization of amino‐1,6‐enynes
Authors: Komeyama Kimihiro , Miyagi Motoyoshi , Takaki Ken 
Published: September 2008

AbstractBi(OTf)3 effectively catalyzed the cyclization of amino‐1,6‐enynes, leading to bicyclic amine and cyclopentadienyl amino compounds. The selectivity of the products depends on the substitution pattern of the olefinic moiety. 19F NMR trace experiment of the reaction and other results indicate a novel alkynophilicity of the bismuth species. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:644–648, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20490
2D free‐breathing dual navigator‐gated cardiac function validated against the 2D breath‐hold acquisition
Authors: Peters Dana C. , Nezafat Reza , Eggers Holger , Stehning Christian , Manning Warren J. 
Published: September 2008

AbstractPurposeTo develop and validate a free‐breathing cardiac cine acquisition, with potential to simplify cardiac MR studies, provide registered slices, and increase spatial resolution.Materials and MethodsA 2D free‐breathing (FB) navigator‐gated cine radial acquisition for cardiac function was developed that used two navigators (one placed prior to the QRS, and another 500 msec after the QRS complex, after systole) to provide complete motion‐compensated assessment of systole, without loss of end‐diastole. Eleven subjects were studied.ResultsThe 2D FB method provided results visually and quantitatively similar to the 2D breath‐hold (BH) methods. Comparison of volumes measured with FB to those measured by standard 2D BH cine resulted in mean bias ± 2 standard deviations of 1.0 mL ± 13.7 mL, 1.1 mL ± 7.6 mL, 3.0 g ± 18.8 g, and 0.3% ± 2.5%, for end‐diastolic volume, end‐systolic volume, left ventricular (LV) mass, and ejection fraction, respectively. Slice misregistration was identified in four (36%) of the BH studies, but none (0%) of the FB studies. In subjects with slice misregistration, there was greater discordance in LV volume measurements (P < 0.05 for end‐diastolic mass).ConclusionThe FB cine acquisition provided results qualitatively and quantitatively similar to 2D BH methods with improved slice registration. J. Magn. Reson. Imaging 2008;28:773–777. © 2008 Wiley‐Liss, Inc.
Noninvasive estimation of hepatic steatosis using plain CT vs. Chemical‐shift MR imaging: Significance for living donors
Authors: Yoshimitsu Kengo , Kuroda Yousuke , Nakamuta Makoto , Taketomi Akinobu , Irie Hiroyuki , Tajima Tsuyoshi , Hirakawa Masakazu , Ishigami Kousei , Ushijima Yasuhiro , Yamada Tomomi , Honda Hiroshi 
Published: September 2008

AbstractPurposeTo compare plain computed tomography (CT) and chemical‐shift MR imaging (CSI) for establishing a noninvasive method to estimate the degree of steatosis.Materials and MethodsA total of 58 patients who had histological proof of liver tissue and underwent CT and/or CSI within two weeks, were studied. They consisted of 38 living donor candidates and 20 liver surgery patients without hepatitis or cirrhosis. The CT index (CTI) and MR index (MRI) were defined and correlated to histological grades of steatosis. Correlation was also performed exclusively for mild steatosis (grades 0–2).ResultsBoth plain CT (ρ = 0.74, P < 0.0001) and CSI (ρ = 0.83, P < 0.0001) had good correlation with histological grades of steatosis, showing no significant difference between them. For mild steatosis, CSI (ρ = 0.77, P < 0.0001) had better correlation than CT (ρ = 0.49, P = 0.001) (P = 0.049). Accuracy in differentiation between grade 0–1 vs. grade 2–4 steatosis was 85% using a CTI >6, and 91% using an MRI <0.03 as criteria. That between grade 0–2 and grade 3–4 was 91% using a CTI >–8 and 88% using an MRI <0.25 as criteria.ConclusionBoth plain CT and CSI were useful in estimating the degree of steatosis but CSI was superior to CT in differentiating mild steatosis. These indices may at least partially replace percutaneous biopsy in evaluating grades of steatosis for living donors. J. Magn. Reson. Imaging 2008;28:678–684. © 2008 Wiley‐Liss, Inc.
Diffusion tensor imaging of the auditory pathway in sensorineural hearing loss: Changes in radial diffusivity and diffusion anisotropy
Authors: Lin YuChun , Wang JiunJie , Wu CheMing , Wai YauYau , Yu JenFang , Ng ShuHang 
Published: September 2008

AbstractPurposeTo prospectively compare diffusion tensor imaging (DTI) measures of axial diffusivity (λ∥), radial diffusivity (λ⟂), mean diffusivity (MD), and fractional anisotropy (FA) along the auditory pathway of patients with sensorineural hearing loss (SNHL) and normal controls.Materials and MethodsIn 37 individuals with SNHL and 10 healthy controls, two regions of interest (ROIs) positioned along the auditory pathway—the lateral lemniscus (LL) and the inferior colliculus (IC)—were investigated bilaterally using diffusion tensor imaging at 3 T. SNHL patients were divided into three groups: patients with bilateral hearing loss, patients with unilateral hearing loss, and patients with partial hearing loss. DTI measures (λ∥, λ⟂, MD, FA) of both ROIs were determined in all subjects.ResultsThe FA value was reduced and the λ⟂ was increased both at the lateral lemniscus and the inferior colliculus of patients with SNHL compared with controls. Similar changes were seen between the ipsilateral and contralateral LL and IC for patients of unilateral profound hearing loss. No changes were observed in any other parameters.ConclusionIn SNHL patients DTI showed a high radial diffusivity that consequently led to a decreased fractional anisotropy in the LL and the IC. J. Magn. Reson. Imaging 2008;28:598–603. © 2008 Wiley‐Liss, Inc.