bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetics of inclusion‐body myositis
Authors: Needham M. , Mastaglia F.L. , Garlepp M.J. 
Published: March 2007

AbstractSporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion‐body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion‐body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM. Muscle Nerve, 2007
Pitfalls in the electrodiagnostic studies of sacral plexopathies
Authors: Tavee Jinny , Mays Maryann , Wilbourn Asa J. 
Published: March 2007

AbstractThis retrospective review characterizes the electrodiagnostic (EDX) features and etiologies of sacral plexopathies (SPs) and discusses difficulties in their identification. The EDX findings of 171 clinically suspected SPs were reviewed using the following criteria: reduced/absent sensory nerve action potentials (SNAPs) of the sural or superficial peroneal nerve, denervation of plexus‐innervated muscles, and the absence of paraspinal denervation. Sixty cases localized unequivocally to the sacral plexus. The majority were cancer‐related, followed by traumatic, idiopathic, and iatrogenic causes. Final diagnoses in the remaining 111 cases were indeterminate. Lesions localized to either the plexus or L4–5, S1 roots in 52 cases, the plexus or sciatic nerve in 32 cases, and were equally compatible with an SP, sciatic neuropathy, or radiculopathy in 27 cases. Findings in the EDX evaluation of SPs are often complex and difficult to localize to a specific site due to multiple complicating factors. Frequently, SPs cannot be diagnosed definitively by EDX assessment alone. Muscle Nerve, 2007
Client experiences in work rehabilitation in Sweden: a one‐year follow‐up study
Authors: Wallstedt‐Paulsson Eva , Erlandsson Lena‐Karin , Eklund Mona 
Published: March 2007

AbstractThis study, carried out in a work rehabilitation unit in Sweden, investigated how clients perceived their work experiences after a one‐year follow up. A semi‐structured interview was administered to 14 former clients and a content analysis was applied. Seven categories were derived from the results: ‘Expectations of the rehabilitation process’; ‘Social relationships’; ‘Client influences on the rehabilitation process’; ‘Occupations engaged in during the rehabilitation programme’; ‘Perceived outcome’; ‘Current occupations’; and ‘Future aspirations’. The dominating expectations were to find a job, with an overall desire for change. The social relationships with the staff and other clients were of great importance. The positive outcome of the rehabilitation was described as feeling better or having new skills. The perceived negative outcome was that the rehabilitation programme had not turned out as the client expected. The clients reported varying daily occupations after the rehabilitation experience and a majority were contented and optimistic about their future. The main conclusions of the study are that when planning a work rehabilitation programme, efforts have to be made to examine clients' interests and skills, and to develop a dialogue between clients and staff. Further research is needed to evaluate the work rehabilitation experience from the clients' perspective. Copyright © 2007 John Wiley & Sons. Ltd.
Treatment of pediatric non‐Hodgkin lymphoma in Hungary: 15 years experience with NHL‐BFM 90 and 95 protocols
Authors: Müller Judit , Csóka Monika , Jakab Zsuzsanna , Ponyi Andrea , Erlaky Hajna , Kovács Gábor 
Published: March 2007

AbstractRetrospective analysis was performed to assess the survival‐rates of children with non‐Hodgkin lymphoma (NHL), treated according to the NHL‐BFM (Berlin‐Frankfurt‐Münster)‐90 and ‐95 protocols between 1990 and 2004 in Hungary, and to compare our data with the international results. Ninety‐one patients had non‐B‐NHL, 108 B‐NHL, and 31 ALCL. Complete remission rate was 89%, while 12% relapsed later. The 5‐year‐overall‐survival was 78% and the event‐free survival was 75%. These results are lower than those reported by the BFM study group, but comparable from other European centers. In the last 5 years, the results showed 10% improvement and death during induction was reduced from 10 to 3%. Pediatr Blood Cancer 2008;50:633–635. © 2007 Wiley‐Liss, Inc.
Early‐onset sarcoidosis mimicking refractory cutaneous histiocytosis
Authors: Ohga Shouichi , Ichino Kiyomi , Urabe Kazunori , Ishimura Masataka , Takada Hidetoshi , Nishikomori Ryuta , Furue Masutaka , Hara Toshiro 
Published: March 2007

AbstractA 10‐year‐old female was diagnosed as having early‐onset sarcoidosis (EOS) after a prolonged skin disease. A granuloma emerged on the face at age 2 and massive lesions extended to the rest of the body. Repeated biopsies indicated histiocytic proliferation. At age 7, fever, disseminated macular eruptions, and multinucleated giant cells in the bone marrow prompted vinblastine and prednisolone therapy. Five months after stopping therapy, hypercalcemic crisis occurred along with fever, cytopenias, and interferon‐γ‐nemia indicating a macrophage activation syndrome. A biopsy of nodules confirmed the diagnosis of sarcoidosis. The atypical EOS should be differentiated from histiocytosis. Pediatr Blood Cancer 2008;50:723–726. © 2007 Wiley‐Liss, Inc.
Immune response to conjugated meningococcal C vaccine in pediatric oncology patients
Authors: Yu Joyce W. , Borkowski Astrid , Danzig Lisa , Reiter Stephanie , Kavan Peter , Mazer Bruce D. 
Published: March 2007

AbstractBackgroundFollowing outbreaks of meningococcal disease in Quebec in 1991–1993 and 2000–2001, a mass vaccination campaign was performed. In 2001–2002, children aged 2 months to 20 years were immunized with the Meningococcal CRM197 vaccine (Menjugate™). We examined the response of pediatric oncology patients during or following maintenance chemotherapy and post‐bone‐marrow transplantation to Meningococcal C vaccine.ProcedureThis was an open label descriptive study of a cohort of patients from the oncology clinic at the Montreal Children's Hospital. A positive vaccine response was defined as a fourfold increase in specific IgG from baseline and a bactericidal assay using human complement (hBCA) titer >1:4.ResultsOf the 25 patients with ALL, 13 had a serologic response (average 60‐fold increase). The serologic responders had a higher mean B cell count (0.262) compared to non‐responders 0.068 × 10.9/L [t(23) = 2.843 (P < 0.05)]. Eleven of the 12 non‐responders and 4 of the responders were on maintenance chemotherapy. In addition, two of the five patients post‐bone‐marrow transplant, responded. Fifteen of the 34 patients (44%) had an adequate hBCA response (mean titer 61). The group included 14/18 serologic responders with hBCA response (P < 0.001) and 16/17 non‐serologic responders with no hBCA response (P < 0.001).ConclusionsMeningococcal C‐conjugate vaccine produced variable responses in children with common cancers. Proximity to chemotherapy and total B cell number may help predict likelihood of response. Pediatr Blood Cancer 2007;49:918–923. © 2007 Wiley‐Liss, Inc.
Complementary and alternative therapy use in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
Authors: Mertens Ann C. , Sencer Susan , Myers Cynthia D. , Recklitis Christopher , Kadan‐Lottick Nina , Whitton John , Marina Neyssa , Robison Leslie L. , Zeltzer Lonnie 
Published: March 2007

AbstractBackgroundLittle information is available on the use of complementary and alternative medicine (CAM) in long‐term survivors of childhood and adolescent cancer.ProcedureThe Childhood Cancer Survivor Study (CCSS) is a resource evaluating the long‐term effects of cancer and associated therapies in 5‐year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986 before the age of 21 years. A survey of CAM use during the previous year was distributed in 2000–2001 and completed by 9,984 survivors and 2,474 sibling controls.ResultsCAM use reporting was similar in cases (39.4%) and siblings (41.1%). Compared to female siblings, female survivors were more likely to use biofeedback (odds ratio (OR) = 3.3; 95% CI = 1.0–10.8) and hypnosis/guided imagery (OR = 3.2; 95% CI = 1.6–6.8); male survivors were more likely than male siblings to use herbal remedies (OR = 1.3; 95% CI = 1.1–1.6). Factors associated with CAM use in survivors included elevated scores on the brief symptom inventory (BSI)‐18 (OR = 1.6; 95% CI = 1.3–1.9), prolonged pain (OR  = 1.5; 95% CI = 1.3–1.7), and having seen a physician in the past 2 years (OR = 1.6; 95% CI = 1.4–1.8). Survivors reporting low alcohol intake and excellent or good general health reported lower levels of CAM use (OR = 0.7; 95% CI = 0.7–0.8 and OR = 0.8; 95% CI = 0.7–0.9, respectively).ConclusionsSurvivors have a similar reported use of CAM compared to a sibling cohort. However, our data suggest that survivors turn to CAM for specific symptoms related to previous diagnosis and treatment. Future research is needed to determine whether CAM use reflects unmet health needs in this population. Pediatr Blood Cancer 2008;50:90–97. © 2007 Wiley‐Liss, Inc.
Evidence of population mixing based on the geographical distribution of childhood leukemia in Ohio
Authors: Clark Brenda R. , Ferketich Amy K. , Fisher James L. , Ruymann Frederick B. , Harris Randall E. , Wilkins John R. 
Published: March 2007

AbstractBackgroundThis ecologic study examined the geographic distribution of childhood leukemias in Ohio, 1996–2000, among children aged 0–19 for evidence that population mixing may be a factor.Procedure(1) State incidence rates were compared to Surveillance, Epidemiology and End Results (SEER) rates for each year and for the 5‐year period, 1996–2000; (2) incidence rates for each of Ohio's 88 counties were compared to statewide rates; and (3) county incidence rates were compared based on population density, population growth, and rural/urban locale. SEER*Stat version 5.0 was used to derive age‐specific and 0–19 age‐adjusted rates. Expected values, standardized incidence ratios (SIRs), and Poisson P‐values were calculated with Excel using the indirect method of standardization.ResultsOf the 585 cases, 73.3% were acute lymphocytic leukemia (ALL), 16.6% acute myelogenous leukemia (AML), 3.2% acute monocytic leukemia (AMoL), and 2.6% chronic myelogenous leukemia (CML). Rates for total leukemia burden were significantly below national levels for all races (P = 0.00001), likely due to poor ascertainment of cases. Yearly incidence rates for 1996–2000 were stable for ALL and AML; CML rates declined over the period. Based on 2000 Census and intercensal population estimates for 1996–2000, statistically higher rates for ALL were noted for counties experiencing >10% population change 1990–2000 (P < 0.05), especially for ages 1–4 (P < 0.03) in counties with 10–20% growth. Counties 67.9–99.2% urban experienced fewer than expected cases of AML + AMoL (P < 0.06).ConclusionData support Kinlen's theory of population mixing and warrant further studies in Ohio, the US and other countries. Pediatr Blood Cancer 2007;49:797–802. © 2007 Wiley‐Liss, Inc.
The balance between durability, reliability, and affordability in structural composites manufacturing
Authors: Cabrera‐Ríos Mauricio , Castro José M. 
Published: March 2007

AbstractFiber reinforced structural composites will play a key role in the development of the next generation of transportation vehicles (passenger cars, vans, light trucks, and heavy trucks) because of their high strength‐to‐weight and stiffness‐to‐weight ratio compared with metals. An integrated assessment of the durability, reliability, and affordability of these materials is critical to facilitate the inclusion of these materials into new designs. The result of this assessment should provide information to find the balance between the three performance measures. This paper describes a method to develop this assessment in the fabrication of sheet molding compound (SMC) parts, and discusses the concept of Preform Insert Assembly (PIA) for improved affordability in the manufacturing of composite parts. POLYM. COMPOS., 28:233–240, 2007. © 2007 Society of Plastics Engineers
Phanerochaete chrysosporium soluble proteome as a prelude for the analysis of heavy metal stress response
Authors: Özcan Servet , Yıldırım Volkan , Kaya Levent , Albrecht Dirk , Becher Dörte , Hecker Michael , Ozcengiz Gulay 
Published: March 2007

AbstractA 2‐D reference map in pI range 3–10 was constructed for the soluble protein fraction of Phanerochaete chrysosporium growing vegetatively under standard conditions. Functional annotation could be made for 517 spots out of 720 that were subjected to MALDI‐TOF‐MS analysis, according to the specific accession numbers from the P. chrysosporium genomic database. Further analysis of the data revealed 314 distinct ORFs, 118 of which yielded multiple spots on the master gel. Functional classification of the proteins was made according to the eukaryote orthologous groups defined in the organism's genome website. The functional class of PTMs, protein turnover and chaperones was represented with the highest number (63) of the identified ORFs. Six proteins were assigned to the hypothetical proteins and 29 were predicted to have a signal peptide sequence. Subcellular localization predictions were also made for the identified proteins. Of the protein spots detected on the master gel, 380 were found to be probably phosphorylated and 96 of these matched to the identified proteins. The reference map was efficiently used in the identification of the proteins differentially expressed under cadmium and copper stress. Three new ribosomal proteins as well as zinc‐containing alcohol dehydrogenase, glucose‐6‐phosphate isomerase, flavonol/cinnamoyl‐CoA reductase, H+‐transporting two‐sector ATPase, ribosomal protein S7, ribosomal protein S21e, elongation factor EF‐1 alpha subunit were demonstrated as the most strongly induced.
2‐DE analysis of a new human cell line EM‐G3 derived from breast cancer progenitor cells and comparison with normal mammary epithelial cells
Authors: Selicharová Irena , Smutná Kateřina , Šanda Miloslav , Ubik Karel , Matoušková Eva , Buršíková Eva , Brožová Markéta , Vydra Jan , Jiráček Jiří 
Published: March 2007

AbstractWe performed a 2‐DE analysis of proteins of the newly established spontaneously immortalized clonal cell line EM‐G3 derived from a primary lesion of infiltrating ductal breast carcinoma. EM‐G3 cells may represent progenitors of the mammary epithelial cells spontaneously immortalized in early phase of cancerogenesis. We compared the protein profile of EM‐G3 line with proteins from populations of normal mammary epithelial cells (NME), and determined the phenotype of both types of cells. NME cells are a mixture of both main cell types in breast epithelia, myoepithelial and luminal cells. The EM‐G3 breast cancer cell line has a unique basal‐like phenotype. We identified proteins that are differently expressed in these cells. Cytokeratin 16, cytokeratin 19, squamous cell carcinoma antigen 1, caphepsin B and caspase 14 were predominantly expressed by NME cells. Cytokeratin 13, isoelectric variant of annexin 5, isoelectric variant of chloride intracellular channel protein 1, glyoxalase 1 and glutamine synthetase were predominantly expressed by EM‐G3 cells. The proteins up‐regulated in EM‐G3 cells may represent potential protein markers of mammary epithelial cells progenitors and may be important in early phase of carcinogenesis.
Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine‐induced model of convulsive status epilepticus
Authors: Greene Nicholas D. E. , Bamidele Abiodun , Choy ManKin , de Castro Sandra C. P. , Wait Robin , Leung Kit‐Yi , Begum Shajna , Gadian David G. , Scott Rod C. , Lythgoe Mark F. 
Published: March 2007

AbstractConvulsive status epilepticus is associated with subsequent hippocampal damage and development of mesial temporal sclerosis in a subset of individuals. The lithium pilocarpine model of status epilepticus (SE) in the rat provides a model in which to investigate the molecular and pathogenic process leading to hippocampal damage. In this study, a 2‐DE‐based approach was used to detect proteome changes in the hippocampus, at an early stage (2 days) after SE, when increased T2 values were detectable by magnetic resonance imaging. Gel image analysis was followed by LC‐MS/MS identification of protein species that differed in abundance between pilocarpine‐treated and control rats. The most significantly up‐regulated species in the experimental animals was identified as heat shock 27‐kDa protein, in line with findings in humans and in other experimental models of epilepsy. Additional up‐regulated species included dihydropyrimidinase‐related protein‐2, cytoskeletal proteins (α‐tubulin and ezrin) and dihydropteridine reductase. In summary, the hippocampus of rats subject to pilocarpine‐induced SE exhibits specific changes in protein abundance, which likely relate to pathogenic, neuroprotective and neurogenic responses.
Novel heterocyclic poly(arylene ether ketone)s: Synthesis and polymerization of 4‐(4′‐hydroxyaryl)(2H)phthalazin‐1‐ones with methyl groups
Authors: Cheng Lin , Ying Lei , Feng Juan , Wang Chen Yi , Li Jian Ling , Xu Zhen 
Published: March 2007

AbstractBased on green chemistry, a simple and efficient direct synthesis of 4‐(4′‐hydroxyaryl)(2H)phthalazin‐1‐ones (2a–2f) was developed in a two‐step reaction, in which the Friedel–Crafts acylation reaction of six phenols with phthalic anhydride was initially carried out and then followed by cyclization with hydrazine hydrate in good to excellent yields with high regioselectivity. A number of novel heterocyclic poly(arylene ether ketone)s were prepared conveniently from several unsymmetrical, twist, and noncoplanar phthalazinone‐containing monomers (2a–2f) and an activated difluoro monomer via a NC coupling reaction. It was very interesting that the obtained monomers and polymers exhibited diverse properties with the variation of the number and location of the substituted methyl groups. All these polymers had a high molecular weight with Mn and ηinh in the range of 44,960–169,000 Da and 0.38–0.79 dL/g, respectively. Actually, the obtained polymers displayed excellent thermal properties with Tg's ranging from 222 to 248 °C and 5% weight loss temperatures in nitrogen higher than 430 °C. Moreover, these polymers were readily soluble in common organic solvents, such as N‐methyl‐2‐pyrrolidone, chloroform, pyridine, and m‐cresol, and could be cast into flexible and colorless or nearly colorless films by spin‐coating or casting processes. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1525–1535, 2007
Thermally curable benzoxazine monomer with a photodimerizable coumarin group
Authors: Kiskan Baris , Yagci Yusuf 
Published: March 2007

AbstractA new monomer, 4‐methyl‐9‐p‐tolyl‐9,10‐dihydrochromeno[8,7‐e][1,3]oxazin‐2(8H)‐one, possessing both benzoxazine and coumarin rings in its structure was synthesized by the reaction of 4‐methyl‐7‐hydroxycoumarin, paraformaldehyde, and p‐toluidine in methanol at 40 °C and characterized with spectral analysis. Upon photolysis around 300 nm, this monomer underwent dimerization via the [2πs+2πs] cycloaddition reaction. Photodimerization reactions were investigated with UV and 1H NMR spectroscopy measurements. The thermal ring‐opening reaction of the benzoxazine ring was demonstrated with differential scanning calorimetry measurements. The thermal behavior of the cured product was also investigated with thermogravimetric analysis. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1670–1676, 2007
Helical poly(phenylacetylene) derived from L‐tyrosine: A promising candidate for functional helical polymers carrying transformable N‐ and C‐termini
Authors: Zhao Haichao , Sanda Fumio , Masuda Toshio 
Published: March 2007

AbstractA novel optically active phenylacetylene derivative, N‐(tert‐butoxycarbonyl)‐4‐ethynyl‐L‐phenylalanine methyl ester (1), was synthesized from L‐tyrosine and polymerized with a rhodium catalyst. The corresponding polymer [poly(1)] with a moderate molecular weight was obtained in a high yield. The alkaline hydrolysis of poly(1) gave poly[N‐(tert‐butoxycarbonyl)‐4‐ethynyl‐L‐phenylalanine] [poly(2)] carrying free carboxy groups. Polarimetric, CD, and UV–vis spectroscopy analyses revealed that poly(1) took a predominantly one‐handed helical structure in MeOH and toluene, and poly(2) took a helical structure in MeOH. The secondary structures of poly(1) and poly(2) could be tuned with heat and solvents. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1691–1698, 2007
Integrated scenarios for assessing biodiversity risks
Authors: Spangenberg Joachim H. 
Published: March 2007

AbstractThe rapid loss of biodiversity (however measured) constitutes an urgent need to develop policy strategies that reduce the anthropogenic pressures on biodiversity. To go beyond short‐term curative measures, such strategies must address the driving forces causing the pressures in an integrated fashion, covering a wide range of policy domains. The development of scenarios and their illustration by modelling are essential tools to study the aggregate human impacts on biodiversity, and to derive well founded policy options to preserve it. However, so far socio‐economic, climate and biodiversity models exhibit a wide range of assumptions concerning population development, economic growth and the resulting pressures on biodiversity. This paper summarizes the efforts undertaken in the framework of the ALARM project by an interdisciplinary team of economists, climatologists, land use experts and modellers to identify pressures and drivers, and to derive effective policy strategies. It describes the challenges of such a kind of work, bringing together different world views necessarily inherent to the different fields of investigation, presents preliminary results, indicates necessary policy priorities and suggests urgent issues for future research. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.