bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Ipilimumab, Nivolumab, and Panitumumab in Patients With
KRAS
/
NRAS
/
BRAF
Wild-Type Microsatellite Stable Metastatic Colorectal Cancer
Authors: Somasundaram Ashwin , Moore Dominic T. , Turk Anita A. , Imanirad Iman , Cohen Stacey A. , Ciombor Kristen K. , Triglianos Tammy , McRee Autumn J. , Lee Michael S. , Sanoff Hanna K. 
Published: February 2025

PURPOSE

Panitumumab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), is standard therapy for patients with
KRAS/NRAS/BRAF
wild-type (WT), microsatellite stable (MSS), metastatic colorectal cancer (mCRC). We hypothesized that the addition of ipilimumab (anti–cytotoxic T-cell lymphocyte-4) and nivolumab (anti-PD1) to panitumumab would increase response rate.

METHODS

This is a phase II, multicenter, single-arm trial of panitumumab, ipilimumab, and nivolumab in
KRAS
/
NRAS
/
BRAF
WT, MSS mCRC. Eligible patients had received ≥1 previous lines of therapy and no previous anti-EGFR or immune checkpoint inhibitor. Patients received ipilimumab 1 mg/kg IV once every 6 weeks, nivolumab 240 mg IV once every 2 weeks, and panitumumab 6 mg/kg IV once every 2 weeks until progression, toxicity, or patient withdrawal. The primary outcome was overall response rate at 12 weeks. Using a Simon's two-stage design, with null and alternative hypothesis response rates of 22% and 35%, responses in ≥17 patients of 56 would be considered worthy of additional study.

RESULTS
In 56 patients enrolled between March 2018 and June 2020, the response rate was 32.1% (95% CI, 21.4 to 45.2; n = 18). The median progression-free survival was 6.0 months (95% CI, 5.5 to 7.4), and the median overall survival was 17.4 months (95% CI, 14.2 to 27.5). With a median follow-up of 43.3 months (95% CI, 41 to 55), four patients (10.7%) were alive without progression, including two patients with liver metastases. There was one treatment-related grade 5 myocarditis. The most common treatment-related grade 3 to 4 toxicities included lipase increased (9%), amylase increased (7%), ALT increased (5%), AST increased (5%), diarrhea (5%), hypophosphatemia (5%), and maculopapular rash (5%).

CONCLUSION
The combination of panitumumab, ipilimumab, and nivolumab demonstrated an acceptable response rate including a signal of durable response even among patients with liver metastases, suggesting activity of immune checkpoint inhibitors combined with anti-EGFR therapy in MSS mCRC.
Conocimientos y hábitos en finanzas personales de los universitarios del programa de Administración de Empresas de la Universidad Surcolombiana
Authors: Calderón Barrera Lilia Socorro , Rengifo Gónzalez Maber , Quiroz Cabrera Jaime Eduardo 
Published: February 2025

Objetivo: determinar los conocimientos y hábitos en finanzas personales (FP) de los estudiantes del programa de Administración de Empresas de la Universidad Surcolombiana en la sede de Garzón (Huila, Colombia). Metodología: se empleó un enfoque mixto, con alcance descriptivo, un diseño no experimental transeccional descriptivo y teoría fundamentada para crear el modelo de FP. El análisis estadístico se realizó con el software Statgraphics Centurion XVI, con un nivel de significancia inferior a 0.05. Se utilizó un cuestionario de 84 preguntas, validado por expertos, a una muestra de 175 estudiantes matriculados entre el 2019 y el 2023, con una población de 319 estudiantes, un margen de error del 5 % y un nivel de confianza del 95 %. Resultados principales: en promedio, el 44.78 % de los estudiantes aprobaron la prueba de conocimientos, y el 51.69 %, el test de hábitos. Ello indica que más de la mitad de los encuestados tiene falencias en cuanto a conocimientos y hábitos en FP. Conclusiones: los estudiantes requieren potenciar sus conocimientos y hábitos en materia de FP,liderados desde el Ministerio de Educación Nacional, las instituciones educativas públicas y privadas, además de incluir esta asignatura de manera transversal en los currículos.
ANÁLISE DA INFLUÊNCIA DAS FEIÇÕES ESTRUTURAIS DA FORMAÇÃO SERRA GERAL NA DISPONIBILIDADE HÍDRICA SUBTERRÂNEA DO SISTEMA AQUÍFERO SERRA GERAL
Authors: Johann Nery Bianca , Mancuso Malva Andrea , Emiliano Santos Caroline 
Published: February 2025

Mapeamento de áreas visando o potencial de produção hídrica subterrânea, subsidia políticas públicas que atendem o Objetivo de Desenvolvimento Sustentável 6 proposto pela ONU: disponibilidade e gestão sustentável da água para todos. Atendendo ao objetivo, este estudo buscou definir áreas hídricas potenciais de abastecimento subterrâneo, no âmbito da Bacia Hidrográfica do Rio da Várzea, avaliando a produtividade dos poços (capacidade específica) e a sua relação com os elementos geológico-estruturais da Formação Serra Geral: tipo de rocha; tipo de aquífero; espessura de solo; direção de lineamentos; intersecção entre lineamentos; e densidade de lineamentos. Os resultados indicam maior capacidade específica em poços sob as Fáceis Paranapanema, sob o Sistema Aquífero Serra Geral I e sob solos com espessura intermediária. Lineamentos nas direções SE-SSE e E-ESE apresentaram correlação proporcional entre a maior capacidade específica e a maior densidade de lineamentos. A análise de intersecções de lineamentos não apresentou significância, com exceção da maior classe de densidade (>0,1/km2). As direções de lineamentos com poços a menos de 1 km de distância, com maior capacidade específica, foram: ESE-SE e NE- ENE.
HISTÓRIAS DA GEOGRAFIA HUMANISTA NO BRASIL:
Authors: SOARES FAGNO 
Published: February 2025

Entrevista realizada em 29 de maio de 2023, com o geógrafo humanista brasileiro, Eduardo Marandola Jr., professor da Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas (Unicamp/Campus Limeira). Durante a entrevista, Eduardo Marandola Jr. tratou brevemente, de sua trajetória pessoal e de como a Geografia Humanista o alcançou. Realizou reflexões sobre o ofício do geógrafo humanista no século XXI, passando pelo temário dos estudos de Percepção do Meio Ambiente até o processo de fortalecimento dos estudos em Geografia Humanista e dos primeiros impactos causados pela abordagem fenomenológica na produção geográfica brasileira. Por fim, falou particularmente da contribuição dos geógrafos Yi-Fu Tuan e Lívia de Oliveira na chegada, difusão e consolidação dos estudos fenomenológicos na geografia brasileira.
Palavras-chaves: Geografia Humanista. Percepção. Espaço. Lugar.
Prevalence and associated factors of depression among adult refugees in East Africa: A protocol for systematic review and meta-analysis
Authors: Shibeshi Abdu Hailu , Moloro Abdulkerim Hassen , Kase Bizunesh Fantahun , Wubshet Betel Zelalem , Seid Abubeker Alebachew 
Published: February 2025

Introduction
Depression is a common mental health problem among adult refugees in East Africa. Refugees in this region face numerous challenges, including mental health issues, with depression being one of the most common and debilitating conditions. However, there is a lack of systematic reviews and meta-analyses that have been conducted to determine the pooled prevalence and associated factors of depression among adult refugees in East Africa. This study aims to assess the prevalence of depression and its associated factors among adult refugees in East Africa through an analysis of pooled data.

Materials and methods
A comprehensive search of MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, and African Journals Online (AJOL) will be conducted to identify studies that have reported the prevalence and associated factors of depression among adult refugees in East Africa. A checklist from the Joanna Briggs Institute (JBI) will be used to assess the methodological quality. The search will be limited to studies published in English. Data extraction, critical appraisal, and screening of all the retrieved articles will be conducted by two independent researchers. Statistical analysis will be performed using STATA-17 software packages. The meta-analysis will be conducted using a random-effects model. The heterogeneity of the studies will be assessed using the I2 statistic. The publication bias will be assessed using the funnel plot and Egger’s test. For determinants of depression, an effect size with a 95% confidence interval will be reported.

Ethics and dissemination
Ethical approval and informed consent are not required as this is a systematic review of existing publications. The final results will be published in a peer-reviewed journal and presented at national and international conferences.
PROSPERO registration number: CRD42024496728
Fashion Projects: 15 Years of Fashion in Dialogue, Francesca Granata (ed.) (2024)
Authors: Matheson Linda Florence 
Published: February 2025

Review of: Fashion Projects: 15 Years of Fashion in Dialogue, Francesca Granata (ed.) (2024)
Bristol: Intellect, 225 pp.,
ISBN 978-1-78938-893-0, h/bk, $134.95
ISBN 978-1-78938-894-7, e-book, $103.95
ISBN 978-1-78938-895-4, e-PDF, $103.95
Tribal and the Cultural Legacy of Streetwear, G. James Daichendt (ed.) (2024)
Authors: Reynders Dirk 
Published: February 2025

Review of: Tribal and the Cultural Legacy of Streetwear, G. James Daichendt (ed.) (2024)
Bristol: Intellect Books, 240 pp.,
ISBN 978-1-78938-808-4, p/bk, EUR 29.99
Butts: A Backstory, Heather Radke (2022)
Authors: Sperling Joy 
Published: February 2025

Review of: Butts: A Backstory, Heather Radke (2022)
New York: Avid Reader Press, 310 pp.,
ISBN 978-1-98213-548-5, h/bk, $28.99
ISBN 978-1-98213-549-2, p/bk, $18.99
ISBN 978-1-98213-552-2, e-book, $14.99
Disseminated Varicella-Zoster and Acute Liver Failure in a Patient With Crohn's Disease on Systemic Immunosuppression
Authors: Shore Brandon , Fix Oren K. , Hansen Jonathan J. 
Published: February 2025

ABSTRACT
Approximately 4 million cases of varicella-zoster occur annually, most of which are self-limited and managed conservatively with supportive care with or without oral valacyclovir. However, varicella-zoster rarely disseminates leading to severe systemic illness affecting multiple organs. Disseminated varicella-zoster causes significant morbidity and mortality, particularly in immunocompromised individuals. In this study, we report a case of a 27-year-old immunosuppressed man who developed disseminated varicella-zoster infection culminating in multiorgan failure and death. We review the epidemiology, risk factors, diagnosis, prevention, and treatment of disseminated varicella-zoster.
Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice
Authors: Sharma Lokesh , Singh Ravineel B. , Ngeow Caden , van der Geest Rick , Duray Alexis M. , Tolman Nathanial J. , McVerry Bryan J. , Dela Cruz Charles S. , Alcorn John F. , Bain William , Robinson Keven M. 
Published: February 2025

AbstractInfluenza infections are often complicated by secondary bacterial infections such as MRSA pneumonia, which increase morbidity and mortality. Viral infections lead to an inflammatory response that includes elevated levels of IL‐6 and interferons. IL‐6 activates the JAK/STAT signaling pathway, amplifying downstream inflammation. Given the clinical efficacy of the JAK inhibitor baricitinib in reducing disease severity in COVID‐19, we evaluated its impact in a murine model of influenza, MRSA, and post‐influenza MRSA pneumonia. Additionally, because IL‐6 inhibitory therapies have improved outcomes during COVID‐19, we evaluated the impact of IL‐6 deletion on post‐influenza MRSA pneumonia. In our studies, baricitinib effectively inhibited the JAK/STAT pathway in the lungs, as demonstrated by decreased interferon‐stimulated genes (ISGs) and STAT3 phosphorylation. Despite this inhibition, baricitinib did not cause a global suppression of cytokines. Notably, baricitinib treatment did not impair either antiviral or antibacterial host immunity, inflammatory cell recruitment, or lung tissue injury. IL‐6 deficiency did not alter weight loss, inflammatory cell recruitment, or bacterial burden during post‐influenza MRSA pneumonia. These findings suggest that both JAK inhibition via baricitinib and IL‐6 deletion do not enhance host defense or limit tissue injury in murine models of influenza and post‐influenza MRSA pneumonia.
Grand Triebel-Lizorkin-Morrey spaces
Authors: Ho Kwok-Pun 
Published: February 2025

Abstract
This article studies the Triebel-Lizorkin-type spaces built on grand Morrey spaces on Euclidean spaces. We establish a number of characterizations on the grand Triebel-Lizorkin-Morrey spaces such as the Peetre maximal function characterizations, the Lusin area function characterizations, and the

g

λ

∗

{g}_{\lambda }^{\ast }

function characterizations. The boundedness of the Fourier multipliers on the grand Triebel-Lizorkin-Morrey spaces is also obtained.
Between core and periphery: the development in English of a modal adverb, an evaluative adverb and a discourse connector
Authors: Lewis Diana 
Published: February 2025

Abstract
In recent discourse approaches to the peripheries, sentence adverbs have received less attention than categories such as pragmatic markers or discourse connectors. This study compares the development of sentence adverbs and discourse connectors via a case study of evidential apparently, evaluative sadly, and discourse-connector instead. These expressions occur in present-day English in all three ‘peripheral slots’. The study shows that the three expressions evolved into peripheral stance expressions via similar mechanisms, the developments being favoured by occurrence in constructions which appear to provide ‘bridging contexts’. The expressions are viewed in the light of two models of the development of such peripherals: Grammaticalization theory and Diachronic Construction Grammar. The findings point to some compatibility with a discourse-prominence-based approach to grammaticality and some compatibility with a model of productivity within a higher-level modification schema. Apparent regularities in the diachronic development, together with parallels between sentence modifiers and constituent modifiers, and synchronic relations between the constituent source items and the emergent peripheral items, suggest that the ‘boundary’ between core and periphery is both permeable and gradient rather than clear-cut.
Preparation of Co/Cr-MOFs for efficient removal of fleroxacin and Rhodamine B
Authors: Wei Fuhua , Wang Yan , Ren Qinhui , Zhang Qin , Chen Hongliang , Liang Zhao 
Published: February 2025

Abstract
Cr/Co-MOFs were synthesized via a solvothermal method using chromium acetate and cobalt chloride hexahydrate as metal ions, and trimeric acid as the organic ligand. The structures of Cr/Co-MOFs were characterized using Fourier infrared spectroscopy, X-ray diffraction, and scanning electron microscopy techniques. These Cr/Co-MOFs were used for removing organic contaminants in wastewater treatment. Fleroxacin and Rhodamine B (RhB) were specifically selected as target molecules in this study to evaluate the removal efficiency based on the mass of Co/Cr-MOFs, concentrations of organic contaminants, and adsorption time. Experimental findings indicated that at a Co/Cr-MOFs dosage of 100 mg, with initial concentrations of Fleroxacin (30 ppm) and RhB (20 ppm), removal efficiencies achieved were 95% and 99%, respectively. Within a timeframe of 5 h, Co/Cr-MOFs attained adsorption capacities amounting to 269.6 mg·g−1 for fleroxacin and 289.5 mg·g−1 for RhB. The interaction between Co/Cr-MOFs and fleroxacin, as well as RhB, is primarily attributed to factors such as pore size, hydrogen bonding, electrostatic charge, and π–π interactions. Moreover, theoretical analysis corroborated these experimental results by demonstrating conformity between the adsorption process and both second-order kinetic model equations alongside Langmuir isotherm model equations. Collectively, the experimental data combined with theoretical investigations underscore the practical significance associated with employing Co/Cr-MOFs for effective eradication of organic pollutants.
Analyzing the effects of solid fraction and heat treatment on the mechanical properties of 3D printed polymer lattices
Authors: Markandan Kalaimani , Ibrahim Abdirahman Yasin , Natarajan Elango , Khalili Pooria , Naidu Dewika 
Published: February 2025

Abstract
Additive manufacturing techniques have made it possible to create lighter and stronger lattice structures with intricate repeating geometric patterns which can be utilized for various industrial applications. Although several studies have reported on the effects of lattices with varying geometry on mechanical properties, fewer studies have investigated the effects of post-processing parameters on mechanical properties of these lattices. As such, this study investigates the effects of solid fraction of octet truss-based lattices and the effect of heat treatment on the mechanical properties of 3D printed octet truss lattices. Experimental findings revealed that Young’s Modulus and strength of lattices were enhanced upon heat treatment where tensile strength and stiffness of lattices with 40 % solid fraction improved by 20.55 % and 29.11 % respectively. Besides, it was found that the lattices without and with heat treatment obeyed the Ashby’s classic scaling law reasonably well for both modulus-density and strength-density relationship.
Influence of the viscosity of polymer melts on the coextrusion process based on wall slip conditions
Authors: Deng Xiaozhen , Chen Tianrong , Xiao Bing , Ren Zhong , Tang Gang , Xu Fang , Yan Xiaoxiao 
Published: February 2025

Abstract
Three-dimensional viscoelastic flow numerical models for the polymer coextrusion process were established on the basis of two different wall conditions and solved via finite element methods. The influence of polymer melt viscosity on the coextrusion process was investigated by analyzing die swell, melt interlayer interface stability and flow field distribution under two different wall slip conditions, namely, sticky adhesive condition and fully slip non adhesive condition. The results indicate that in the traditional coextrusion process with sticky adhesive condition, the die swell, interface stability and flow field distribution change with the melt viscosity, but the effects of the shell melt viscosity differ from those of the core melt viscosity. The die swell, interface offset degree and radial flow strength (orthogonal to the flow direction) increase with increasing shell melt viscosity and decrease with increasing core melt viscosity. The die pressure drop, shear rate and first normal stress difference increase with increasing shell or core melt viscosity, but the influence of the shell melt viscosity is much greater than that of the core melt viscosity. In the gas-assisted coextrusion process with fully slip non adhesive condition, the die swell, interface stability and flow field distribution are not affected by the viscosity of both polymer melts which means that the flow behavior in the coextrusion channels is independent of the polymer viscosity. There is no die swell or interface deviation phenomenon, nor any melt radial flow. The die pressure drop, shear rate and first normal stress difference are close to zero, except in the close vicinity of the die inlet. This approach not only ensures product quality but also solves the problem of material selection for polymer coextruded products. In addition, the goal of energy conservation and consumption reduction has been achieved, and the energy savings and consumption reduction effects are particularly significant for high-viscosity melts.
Temperature and pups influence daytime roosting behavior of the great fruit-eating bat, Artibeus lituratus, in an urban southern Brazilian habitat
Authors: Generoso Sam , Quintas Schaucoski Victor , Miranda João M.D. , Colares Renato , Carvalho Fernando 
Published: February 2025

Abstract
Urbanization affects animal behavior, making ethology crucial for understanding its full impact. Artibeus lituratus is the most captured bat species in urban environments in Brazil, yet its ethology has never been studied in the country. Furthermore, there is much to be uncovered about the roles temperature and offspring play in influencing bat behavior. Thus, this study aimed to analyze the behavior of a group of roosting A. lituratus, and to test the influence of temperature and presence of offspring on their behaviors. A group of A. lituratus was observed roosting under palm leaves, on the Campus of Universidade do Extremo Sul Catarinense. Ad libitum sampling was used for behavior description, whereas Scan sampling was used to analyze the activity patterns and test the influence of temperature and offspring. Sixteen behaviors were distinguished. The bats were observed during daytime, and were the most active between 09:00 and 16:00, and lowest at 07:00, 8:00, and 17:00. Ambient temperature was positively correlated with behaviors “active” and “self-grooming”, and negatively correlated with “inactive”. “Allogrooming” was more abundant when offspring were present. This study provides the first ethological insights into A. lituratus in Brazil, emphasizing the roles of temperature and offspring in shaping their behavior.
Prognostic implications of PCSK9 expression in HER2-positive breast cancer
Authors: Wu Zongwen , Wu Dina , Huang Chengsheng , Zhang Jinhua , Sun Shijun , Chen Yingzhi , Sun Yanxiang , Ma Shihui 
Published: February 2025

Abstract

Objectives
PCSK9 is critical in cholesterol homeostasis and anti-tumor immunity modulation. This study aims to investigate PCSK9’s role in HER2-positive breast cancer (BC) as a potential prognostic marker.

Methods
The impact of PCSK9 on HER2-positive BC was analyzed by virtue of data from The Cancer Genome Atlas (TCGA). Moreover, PCSK9 expression in tumor cells from 92 HER2-positive patients was assessed through immunohistochemistry (IHC). Then, it was found that this expression was correlated with various clinicopathological parameters including histological grading, hormone receptor (HR) status, and patient survival.

Results
PCSK9 expression positively correlated with pathohistological grading and hormone receptor status, but negatively with patient survival. GSEA showed low PCSK9 expression groups enriched in immune-related pathways, while high expression groups favored coagulation pathways. CIBERSORT analysis revealed a notable negative association between PCSK9 expression and γδ T cells, suggesting PCSK9’s role in modulating tumor microenvironment (TME) immune reactivity. Low PCSK9 expression was associated with a more favorable response to neoadjuvant therapy in patients.

Conclusions
PCSK9 expression in HER2-positive BC is a significant prognostic indicator, with higher levels related to worse clinical outcomes. These results suggest PCSK9’s potential utility in predicting treatment responses and guiding therapeutic strategies for HER2-positive BC patients.
Die Energiewende als gesellschaftliche Transformation: Potenziale der Zivilgesellschaft nutzen
Authors: Schubert Peter , Benning Laura , Schlüter Robert , Krimmer Holger 
Published: February 2025

Zusammenfassung
Das Gelingen der Energiewende wird maßgeblich von dauerhafter Akzeptanz und Unterstützung in der Bevölkerung abhängig sein. Dieses Papier untersucht das Potenzial von Energiegenossenschaften, zur Förderung dieser Akzeptanz und zur Mitgestaltung der Energiewende vor Ort beizutragen. Die Ergebnisse zeigen eine Vielzahl an gesellschaftlichen Mehrwerten des genossenschaftlichen Modells, die in energiewirtschaftlichen Diskussionen jedoch häufig vernachlässigt werden. Gleichwohl stehen Energiegenossenschaften vor mehreren Herausforderungen, wie dem Druck zur Professionalisierung, einem Mangel an politischer Unterstützung und einer noch zu geringen Vielfalt innerhalb der Mitgliedschaft. Darüber hinaus zeigt sich die Notwendigkeit, dass sich Kommunen künftig stärker als bislang als Netzwerke von Akteuren unterschiedlicher gesellschaftlicher Sektoren begreifen, um gesellschaftlichen Wandel gemeinsam zu gestalten.