bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collarless polished tapered stem
Authors: Yates P. J. , Burston B. J. , Whitley E. , Bannister G. C. 
Published: December 2007

We retrospectively reviewed 175 patients (191 hips) who had undergone primary cemented total hip replacement between November 1992 and November 1995 using a collarless polished double-tapered femoral component after a minimum of ten years (mean 11.08; 10 to 12.8). All stems were implanted using contemporary cementing techniques with a distal cement restrictor, pressurised lavage, retrograde cementing with a gun and proximal pressurisation. Clinical outcome was assessed using the Harris Hip score. Radiological analysis was performed on calibrated plain radiographs taken in two planes. Complete radiological data on 110 patients (120 hips) and clinical follow-up on all the surviving 111 patients (122 hips) was available. The fate of all the hips was known. At final follow-up, the mean Harris Hip score was 86 (47 to 100), and 87 of 116 patients (75%) had good or excellent scores. Survival with revision of the stem for aseptic loosening as the endpoint was 100%; and survival with revision of the stem for any reason was 95.9% (95% confidence interval 87.8 to 96.8) at ten years. All the stems subsided vertically at the stem-cement interface in a predictable pattern, at an overall mean rate of 0.18 mm per year (0.02 to 2.16), but with a mean rate of 0.80 mm (0.02 to 2.5) during the first year. The mean total subsidence was 1.95 mm (0.21 to 24). Only three stems loosened at the cement-bone interface. There was excellent preservation of proximal femoral bone stock. There was a high incidence of Brooker III and IV heterotopic ossification affecting 25 patients (22%). The collarless polished tapered stem has an excellent clinical and radiological outcome at a minimum of ten years’ follow-up. The pattern and magnitude of subsidence of the stem within the cement mantle occurred in a predictable pattern, consistent with the design philosophy.
Sealing the skin barrier around transcutaneous implants
Authors: Pendegrass C. J. , Gordon D. , Middleton C. A. , Sun S. Ng. Man , Blunn G. W. 
Published: December 2007

Conventional amputation prostheses rely on the attachment of the socket to the stump, which may lead to soft-tissue complications. Intraosseous transcutaneous amputation prostheses (ITAPs) allow direct loading of the skeleton, but their success is limited by infection resulting from breaching of the skin at the interface with the implant. Keratinocytes provide the skin’s primary barrier function, while hemidesmosomes mediate their attachment to natural ITAP analogues. Keratinocytes must attach directly to the surface of the implant. We have assessed the proliferation, morphology and attachment of keratinocytes to four titaniumalloy surfaces in order to determine the optimal topography in vitro. We used immunolocalisation of adhesion complex components, scanning electron microscopy and transmission electron microscopy to assess cell parameters.We have shown that the proliferation, morphology and attachment of keratinocytes are affected by the surface topography of the biomaterials used to support their growth. Smoother surfaces improved adhesion. We postulate that a smooth topography at the point of epithelium-ITAP contact could increase attachment in vivo, producing an effective barrier of infection.
Rotational acetabular osteotomy for advanced osteoarthritis secondary to developmental dysplasia of the hip
Authors: Okano K. , Enomoto H. , Osaki M. , Shindo H. 
Published: December 2007

We evaluated the results of rotational acetabular osteotomy in 44 hips (42 patients) with advanced osteoarthritis secondary to developmental dysplasia. The mean age of the patients at surgery was 43.4 years (30 to 59) and the mean follow-up was 12.1 years (8 to 19). The mean Merle d’Aubigné clinical score improved from 10.8 points (8 to 15) pre-operatively to 13.5 points (6 to 18) at follow-up. Radiologically, this procedure produced adequate improvement regarding cover of the femoral head. At follow-up, the osteoarthritic stage assessed using the Japanese Orthopaedic Association grading, was improved in 11 hips (25%), unchanged in 22 (50%) and had progressed in 11 (25%). The mean pre-operative roundness index of the femoral head was significantly different in the 33 hips which had improved or maintained their osteoarthritic stage compared with the 11 which had progressed (53.7% vs 63.7%; p < 0.001). Osteoarthritis with a round femoral head is considered to be an indication for rotational acetabular osteotomy, even in advanced stages of the disease.
Percutaneous screw fixationversusconservative treatment for fractures of the waist of the scaphoid
Authors: McQueen M. M. , Gelbke M. K. , Wakefield A. , Will E. M. , Gaebler C. 
Published: December 2007

We randomly allocated 60 consecutive patients with fractures of the waist of the scaphoid to percutaneous fixation with a cannulated Acutrak screw or immobilisation in a cast. The range of movement, the grip and pinch strength, the modified Green/O’Brien functional score, return to work and sports, and radiological evidence of union were evaluated at each follow-up visit. Patients were followed sequentially for one year.Those undergoing percutaneous screw fixation showed a quicker time to union (9.2 weeks vs 13.9 weeks, p < 0.001) than those treated with a cast. There was a trend towards a higher rate of nonunion in the non-operative group, although this was not statistically significant. Patients treated by operation had a more rapid return of function and to sport and full work compared with those managed conservatively. There was a very low complication rate.We recommend that all active patients should be offered percutaneous stabilisation for fractures of the waist of the scaphoid.
The three-pin modified ‘Harrington’ procedure for advanced metastatic destruction of the acetabulum
Authors: Tillman R. M. , Myers G. J. C. , Abudu A. T. , Carter S. R. , Grimer R. J. 
Published: December 2007

Pathological fractures due to metastasis with destruction of the acetabulum and central dislocation of the hip present a difficult surgical challenge. We describe a series using a single technique in which a stable and long-lasting reconstruction was obtained using standard primary hip replacement implants augmented by strong, fully-threaded steel rods with cement and steel mesh, where required. Between 1997 and 2006, 19 patients with a mean age of 66 years (48 to 83) were treated using a modified Harrington technique. Acetabular destruction was graded as Harrington class II in six cases and class III in 13. Reconstruction was achieved using three 6.5 mm rods inserted through a separate incision in the iliac crest followed by augmentation with cement and a conventional cemented Charnley or Exeter primary hip replacement. There were no peri-operative deaths. At the final follow-up (mean 25 months (5 to 110)) one rod had fractured and one construct required revision. Of the 18 patients who did not require revision, 13 had died. The mean time to death was 16 months (5 to 55). The mean follow-up of the five survivors was 31 months (18 to 47). There were no cases of dislocation, deep infection or injury to a nerve, the blood vessels or the bladder.
Bishop Lucas of Túy and the Latin Chronicle Tradition in Iberia
Authors: Reilly Bernard F. 
Published: December 2007

Lucas, bishop of Tuy, was a canon of the shrine of San Isidoro in León, protégé of Queen Berenguela, and figure at the court of her son, King Fernando III, of Leon-Castile. He was also the compiler and author of a world chronicle, Chronicon Mundi , finished about 1238. This study is particularly directed to the final nineteen chapters of his work that treat his own times, between 1188 and 1236. It is an analysis of his attitudes toward the medieval Iberian kings and kingship of that period, toward those monarchs' activities in the reconquista directed against Muslim Iberia, and toward the contemporary Church and churchmen. Lucas' Chronicon , together with the De Rebus Hispaniae of Archbishop Rodrigo Jimenez de Rada finished in 1243, and the Cronica Latina Regum Castellae , completed after 1238 probably by the chancellor of the realm and later Bishop Juan of Soria and Burgos, form part of a remarkable contemporary trilogy of Latin historical works associated with the court of Fernando III. All have also been given a modern critical edition just recently, 2003, 1987, and 1997 respectively, putting their study on a new and more reliable scholarly level. While earlier scholarship had tended to be somewhat dismissive of the Chronicon of Lucas, it here emerges as a robust contribution to the very lively Latin historical compositions of the early thirteenth century in León-Castile.
The use of differential pulse anodic stripping voltammetry and diffusive gradient in thin films for heavy metals speciation in soil solution
Authors: Dytrtová Jana , Šestáková Ivana , Jakl Michal , Száková Jiřina , Miholová Daniela , Tlustoš Pavel 
Published: December 2007

Abstract
In the soil solutions obtained in situ with suction cups from soils (Cambisol and Fluvisol) of pot experiment with Salix smithiana Smith, Lolium perenne L. and Thlaspi caerulescens J. &amp; C. Presl heavy metals species (Cd, Pb and Cu) were assayed by differential pulse anodic stripping voltammetry and diffusive gradient in thin films. Prediction of accumulation performed best at free metal ion concentrations in unchanged pH (in 10−3 mol L−1 NaClO4 base electrolyte). The speciation provided by differential pulse anodic stripping voltammetry according to pH can provide a detailed description of the soil solution matrix. The concentration of free metals in unchanged pH represents a small part of the total content and varied from 0.04 to 0.75% with two exceptions found for accumulating plants (the content of Cd2+ in the soil solution from T. caerulescens was about 6% and the content of Cu2+ in the soil solution from S. smithiana was about 30%). The available concentration as determined by diffusive gradient in thin films was not in correlation with the heavy metals concentration in plant biomass.
RETRACTED ARTICLE: Kinetic and anion degradation products study on photocatalytic degradation of reactive orange 5 solution with phosphotungstic acid
Authors: Zhong Junbo , Zhao Hong , Ma Di , Lian An , Li Minjiao , Xie Bin , Li Jianzhang 
Published: December 2007

Abstract
Increasing environmental pollution caused by toxic dyes is a matter of great concern due to their hazardous nature. So it is crucial to develop processes which can destroy these dyes effectively. It has been generally agreed that reactive orange 5 (KGN) can be effectively degraded in aerated phosphotungstic acid (HPA) in a homogeneous reaction system using near-UV irradiation. In this paper, photocatalytic degradation of reactive orange 5 solutions with phosphotungstic acid was investigated, especially more attention was paid to the kinetic model and the anion degradation products. The results revealed that the photocatalytic degradation reaction of KGN with HPA in a homogenous solution can be described by Langmuir-Hinshelwood equation and Langmuir-Hinshewood kinetic model described it well. The reaction manifested the first order with lower concentration(⩽30 mg L−1) with the limiting rate constant and the adsorption constant in this case being 0.8098 mg L−1 min−1 and 4.359 10−2 L mg−1, respectively. The degradation mechanism of KGN with HPA is different from that with TiO2, the anion products of the two reaction systems are the same. The difference in degradation mechanism of KGN with HPA from that with TiO2 is caused by the nature of the photocatalyst.
Synthesis and superconducting properties of Nd0.33Eu0.08Gd0.58Ba2Cu3Oz materials
Authors: Stoyanova-Ivanova Angelina , Terzieva Stanimira , Shivachev Boris , Mikli Valdek , Vladimirova Latinaka 
Published: December 2007

Abstract
We have studied the effect of the ratio of different rare-earth element on the superconducting properties and phase formation of (Nd0.33Eu0.08Gd0.58)Ba2Cu3Oz ceramic. Bulk NEG samples were prepared using the solid-state reaction process. The superconducting transition for Nd0.33Eu0.08Gd0.58Ba2Cu3Oz is T
c ≈90 K and the value of the critical current density (J
c) is 13.9 A/cm2 at 77 K under zero magnetic fields. This value is twice as high when compared with the (J
c) value of YBCO systems (J
c = 7.31 A/cm2). The obtained bulk sample was used for the production of superconducting Ag-sheathed tapes by OPIT method including hot rolling. The critical current density of the obtained tape (337 A/cm2) is one order higher than the one of the bulk sample.
Quantum phases for a generalized harmonic oscillator
Authors: Bracken Paul 
Published: December 2007

Abstract
An effective Hamiltonian for the generalized harmonic oscillator is determined by using squeezed state wavefunctions. The equations of motion over an extended phase space are determined and then solved perturbatively for a specific choice of the oscillator parameters. These results are used to calculate the dynamic and geometric phases for the generalized oscillator with this choice of parameters.
Efficacy of alternate day dosing of atorvastatin
Authors: Aghasadeghi Kamran , Zare Didar 
Published: December 2007

AbstractAtorvastatin is a synthetic inhibitor of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. It has a longer half life and longer duration of action than that of all other available HMG-CoA inhibitors. We evaluated the efficacy of alternate-day dosing of atorvastatin in comparison with the standard one-daily dose on total cholesterol, low and High-density lipoprotein (LDL and HDL) and triglycerides. This study is a randomized, blinded, and controlled clinical trial. Sixty-six patients with LDL cholesterol of more than 100 mg/dl were enrolled. Baseline fasting lipid profile (total cholesterol, LDL, HDL and triglyceride), liver function tests and creatine kinase were drawn. Patients were randomized to three atorvastatin dose groups. Group I received 10 mg of atorvastatin every day, group II received 20 mg of atorvastatin every day, and group III received 20 mg every other day. After 6 weeks of treatment with atorvastatin, fasting lipid profiles, liver function tests and creatine kinase concentrations were re-taken. Compliance to treatment was assessed at each visit. Of the sixty-six patients enrolled, sixty completed the study. All three regimens significantly reduced total cholesterol and LDL compared to baseline. No statistically significant difference existed between the three groups in regards to total or a percentage decrease in total cholesterol and LDL cholesterol at 6 weeks compared to baseline. All regimens were well tolerated and none of the patients showed significant elevation of liver enzyme or creatine kinase during the course of the study. In conclusions the alternate-day dosing of atorvastatin is an efficacious and safe alternate to daily dosing and yet inexpensive.
Can CYP1A1 siRNA be an effective treatment for lung cancer?
Authors: Mohammed Kulthum , Shervington Amal 
Published: December 2007

AbstractAbstract: Previously, we identified a novel correlation between the upregulated expression of telomerase (hTERT) and cytochrome P450 1A1 (CYP1A1) in A549 human lung cancer cell line. The expression correlation was confirmed by silencing CYP1A1 expression using siRNA technology and observing a silencing of hTERT transcription. Furthermore, silencing CYP1A1 and subsequently downregulating hTERT resulted in the reduction of cancer cell viability by more than 40%, which appeared as early as 24 hours after the treatment. The concomitant downregulation of CYP1A1 and hTERT resulted in rapid cell death. This finding can be further exploited to develop new molecular targets for the treatment of lung cancer.
The cytoplasmic domain of chondrolectin interacts with the β-subunit of rab geranylgeranyl transferase
Authors: Claessens An , Weyn Christine , Merregaert Joseph 
Published: December 2007

AbstractMouse chondrolectin (chodl) was isolated out of the tail tip of four-day old 129/SvJ mice as a by-product of a PCR-based subtractive cDNA library screening. The gene is predominantly expressed in adult skeletal muscle, heart, testes and lungs and in embryonic stadia. Chodl is the mouse homologue of human chondrolectin (CHODL), a gene that encodes for a type Ia transmembrane protein and that is expressed in human testis, prostate, heart and skeletal muscle tissue. CHODL-splice variants (CHODL f, CHODL fΔE, CHODL ΔE) are detected in human leukocytes. The proteins of the chondrolectin family belong to the family of C-type lectins. As the members of this protein family are important for a wide array of biological processes, the function of chodl was investigated by searching for its protein interaction partners. The β-subunit of Rab geranylgeranyl transferase (Rabggtb) was isolated 8 times after a complete Sos recruitment system (SRS) screen with the cytoplasmic domain of chodl. The interaction was confirmed with in vitro transcription/translation and co-immunoprecipitation (co-IP) experiments.
Ordering of diagnostic information in encoded medical images. Accuracy progression
Authors: Przelaskowski A. , Jóźwiak R. , Krzyżewski T. , Wróblewska A. 
Published: December 2007

AbstractA concept of diagnostic accuracy progression for embedded coding of medical images was presented. Implementation of JPEG2000 encoder with a modified PCRD optimization algorithm was realized and initially verified as a tool for accurate medical image streaming. Mean square error as a distortion measure was replaced by other numerical measures to revise quality progression according to diagnostic importance of successively encoded image information. A faster increment of image diagnostic importance during reconstruction of initial packets of code stream was reached. Modified Jasper code was initially tested on a set of mammograms containing clusters of microcalcifications and malignant masses, and other radiograms. Teleradiologic applications were considered as the first area of interests.
Digital holographic cameras and data processing for remote monitoring and measurements of mechanical parts
Authors: Michałkiewicz A. , Kujawińska M. , Stasiewicz K. 
Published: December 2007

AbstractFast growing technology and requirements for testing of different types of materials and devices require new methods and systems for investigation of their parameters. Among the quantities of high interest are shape, deformation, roughness, local materials constants, displacement, and strain fields of elements under load. In the paper, we present novel solutions for digital holographic cameras, which allow for remote monitoring and measurement of the above mentioned quantities at small mechanical objects or at restricted areas of interest at big structures. The systems have compact design, “black box” measurement approach, and allows for fast and accurate measurements performed directly at the element and often in outdoor environment. The principles of digital and optoelectronic reconstruction and phase manipulation are described together with the exemplary measurement results obtained by means of the cameras presented.
Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity
Authors: Gash Don M. , Rutland Kathryn , Hudson Naomi L. , Sullivan Patrick G. , Bing Guoying , Cass Wayne A. , Pandya Jignesh D. , Liu Mei , Choi Dong‐Yong , Hunter Randy L. , Gerhardt Greg A. , Smith Charlie D. , Slevin John T. , Prince T. Scott 
Published: December 2007

AbstractObjectiveTo analyze a cluster of 30 industrial coworkers with Parkinson's disease and parkinsonism subjected to long‐term (8–33 years) chronic exposure to trichloroethylene.MethodsNeurological evaluations were conducted on the 30 coworkers, including a general physical and neurological examination and the Unified Parkinson's Disease Rating Scale. In addition, fine motor speed was quantified and an occupational history survey was administered. Next, animal studies were conducted to determine whether trichloroethylene exposure is neurotoxic to the nigrostriatal dopamine system that degenerates in Parkinson's disease. The experiments specifically analyzed complex 1 mitochondrial neurotoxicity because this is a mechanism of action of other known environmental dopaminergic neurotoxins.ResultsThe three workers with workstations adjacent to the trichloroethylene source and subjected to chronic inhalation and dermal exposure from handling trichloroethylene‐soaked metal parts had Parkinson's disease. Coworkers more distant from the trichloroethylene source, receiving chronic respiratory exposure, displayed many features of parkinsonism, including significant motor slowing. Neurotoxic actions of trichloroethylene were demonstrated in accompanying animal studies showing that oral administration of trichloroethylene for 6 weeks instigated selective complex 1 mitochondrial impairment in the midbrain with concomitant striatonigral fiber degeneration and loss of dopamine neurons.InterpretationTrichloroethylene, used extensively in industry and the military and a common environmental contaminant, joins other mitochondrial neurotoxins, MPTP (1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) and some pesticides, as a risk factor for parkinsonism. Ann Neurol 2007
Neuropathological basis of magnetic resonance images in aging and dementia
Authors: Jagust William J. , Zheng Ling , Harvey Danielle J. , Mack Wendy J. , Vinters Harry V. , Weiner Michael W. , Ellis William G. , Zarow Chris , Mungas Dan , Reed Bruce R. , Kramer Joel H. , Schuff Norbert , DeCarli Charles , Chui Helena C. 
Published: December 2007

AbstractObjectiveMagnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present.MethodsThis report includes 93 subjects from a longitudinally followed cohort recruited for the study of Alzheimer's disease (AD) and subcortical cerebrovascular disease (CVD). MR images were analyzed to quantify cortical gray matter volume, hippocampal volume, white matter hyperintensities, and lacunes. Neuropathological examination quantified CVD parenchymal pathology, AD pathology (defined as Consortium to Establish a Registry for Alzheimer's Disease scores and Braak and Braak stage), and hippocampal sclerosis. Subjects were pathologically classified as 12 healthy control subjects, 46 AD, 14 CVD, 9 mixed AD/CVD, and 12 cognitively impaired patients without significant AD/CVD pathology. Multivariate models tested associations between magnetic resonance and pathological findings across the entire sample.ResultsPathological correlates of cortical gray matter volume were AD, subcortical vascular pathology, and arteriosclerosis. Hippocampal volume was related to AD pathology and hippocampal sclerosis, and the effects of hippocampal sclerosis were greater for subjects with low levels of AD pathology. White matter hyperintensities were related to age and to white matter pathology. Number of MRI lacunes was related to subcortical vascular pathology.InterpretationIn this clinical setting, the presence of lacunes and white matter changes provide a good signal for vascular disease. The neuropathological basis of MR defined cerebral cortical and hippocampal atrophy in aging and dementia is complex, with several pathological processes converging on similar brain structures that mediate cognitive decline. Ann Neurol 2008