bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing CAR‐NK Cells Against Solid Tumors Through Chemical and Genetic Fortification with DOTAP‐Functionalized Lipid Nanoparticles
Authors: Shin Ha Eun , Han Jun‐Hyeok , Park Joo Dong , Park Minji , Han Jieun , Kang Min‐Ho , Lee Jung Seung , Park Chun Gwon , Park Juwon , Kim Hyun‐Young , Cho Duck , Park Wooram 
Published: March 2024

AbstractNatural killer (NK) cells are crucial in the innate immune response and show promise in cancer immunotherapy, but face challenges in activation and targeted gene delivery. In this study, bifunctional lipid nanoparticles (DLNPs) containing 1,2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP), designed to bolster the antitumor efficacy of chimeric antigen receptor‐modified NK (CAR‐NK) cells by facilitating activation and efficient CAR mRNA delivery are introduced. The DLNPs, created by functionalizing FDA‐approved LNP compositions, exhibit excellent mRNA encapsulation and colloidal stability. NK cells primed with DLNPs show increased cytotoxicity against cancer cells via extracellular signal‐regulated kinase/Mitogen‐Activated Protein Kinase pathway modulation and mitochondrial dynamics changes. The DLNPs enter NK cells predominantly through clathrin‐mediated endocytosis, boosting mRNA delivery and overcoming NK cells' resistance to genetic manipulation. CAR‐NK cells targeting glypican‐3, prevalent in hepatocellular carcinoma, show significant therapeutic effects in an orthotopic mouse model. These findings underscore the potential of DLNPs in enhancing CAR‐NK cell therapy for solid tumors, marking a significant stride in NK cell‐based cancer immunotherapy and broadening prospects for NK cell‐related disease interventions.
Hybrid Materials From Peptide Nanofibrils and Magnetic Beads to Concentrate and Isolate Virus Particles
Authors: Hayn Manuel , John Torsten , Bandak Juhaina , Rauch‐Wirth Lena , Abel Bernd , Münch Jan 
Published: March 2024

AbstractPeptide nanofibrils (PNFs) are considered a novel and highly efficient class of retroviral transduction enhancers due to their ability to efficiently bind virus particles and promote their attachment to the membrane of target cells. In this study, the virus‐binding properties of enhancing factor C (EF‐C) PNFs are used to develop a method for concentrating and isolating HIV‐1 particles without the need for centrifugation. Upon incubation in a virus‐laden sample, PNF‐coated magnetic beads facilitate magnetic separation, effectively depleting virus particles from the solution and consequently reducing its infectious nature. Remarkably, the isolated virus particles maintain their infectivity and exhibit an enhanced ability to infect target cells due to the complexation with EF‐C PNFs. This enhancement is pivotal for further virus propagation in cell cultures or detailed analysis. The presented method addresses the urgent need for more rapid, sensitive detection, and purification technologies for viral agents. It provides a tool to efficiently capture, isolate, and concentrate HIV‐1 particles. This may significantly improve the sensitivity of existing diagnostic tools and analytical tests.
Real Competitors to Ruby: The Triel Oxonitridoborates AlB4O6N, Al0.97Cr0.03B4O6N, and Al0.83Cr0.17B4O6N
Authors: Widmann Ingo , Kinik Gülsüm , Jähnig Maximilian , Glaum Robert , Schwarz Marcus , Wüstefeld Christina , Johrendt Dirk , Tribus Martina , Hejny Clivia , Bayarjargal Lkhamsuren , Dubrovinsky Leonid , Heymann Gunter , Suta Markus , Huppertz Hubert 
Published: March 2024

AbstractAlB4O6N, Al0.97Cr0.03B4O6N, and Al0.83Cr0.17B4O6N are the first representatives of the recently established structure‐family of oxonitridoborates containing Al3+. These compounds are isotypic to CrB4O6N and are synthesized in a multi‐anvil press under high‐pressure/high‐temperature conditions of 7.0 GPa/1350 °C. Structural refinement by single‐crystal X‐ray diffraction shows that they crystallize in the space group P63mc (no. 186) with two formula units per cell. Detailed characterization including high‐temperature X‐ray powder diffraction (HT‐XRD), electron probe microanalysis (EPMA), measurements of second harmonic generation (SHG), hardness, photoluminescence properties, vibrational spectroscopy, and band structure calculations reveal intriguing physicochemical properties that strongly resemble the famous material ruby.
Antibacterial Plasma Coating with Aggregation‐Induced Emission Photosensitizers to Prevent Surgical Site Infections
Authors: Sahu Resmarani , Ninan Neethu , Nguyen Ngoc Huu , Wang Jianzhong , Nguyen Manh Tuong , Vasilev Krasimir , Truong Vi Khanh , Tang Youhong 
Published: March 2024

AbstractSurgical site infections (SSI) are major post‐operative complications following surgery. Reducing SSI is a global urgency as they account for huge pecuniary, physiological, and emotional burdens for patients. Antibiotic resistance is the main challenge for surgeons dealing with SSIs. Aggregation‐induced emission photosensitisers (AIE PS) with their distinct optical characteristics, biocompatibility, low toxicity, and target specificity, hold the potential for the treatment of SSI. Herein, a synergetic strategy combining plasma polymerization and AIE PS is adopted to develop coatings that can eradicate SSI‐causing bacteria. These coatings can preferentially kill Gram‐negative and Gram‐positive bacteria over mammalian cells after triggered by light irradiation. The cell viability and immunostaining studies confirmed their biocompatibility on mammalian cells. The antibacterial mechanistic studies explored their ability to generate reactive oxygen species (ROS), which is crucial for overcoming antibiotic resistance. Thus, this study opens an avenue toward antibacterial coatings to decrease the prevalence of SSI.
Liquid‐Assisted Laser Nanotexturing of Silicon: Onset of Hydrodynamic Processes Regulated by Laser‐Induced Periodic Surface Structures
Authors: Borodaenko Yulia , Pavlov Dmitriy , Cherepakhin Artem , Mitsai Eugeny , Pilnik Andrei , Syubaev Sergey , Gurbatov Stanislav O. , Modin Evgeny , Porfirev Aleksey P. , Khonina Svetlana N. , Shevlyagin Aleksandr V. , Gurevich Evgeny L. , Kuchmizhak Aleksandr A. 
Published: March 2024

AbstractUpon systematic studies of femtosecond‐laser processing of monocrystalline Si in oxidation‐preventing methanol, it is shown that the electromagnetic processes dominating at initial steps of the progressive morphology evolution define the onset of the hydrodynamic processes and morphology upon subsequent multi‐pulse exposure. Under promoted exposure quasi‐regular subwavelength laser‐induced periodic surface structures (LIPSSs) are justified to evolve through the template‐assisted development of the Rayleigh‐Plateau hydrodynamic instability in the molten ridges forming quasi‐regular patterns with a supra‐wavelength periodicity and preferential alignment along polarization direction of the incident light. Subsequent exposure promotes fusion‐assisted morphology rearrangement resulting in a spiky surface with random orientation, yet constant inter‐structure distance correlated with initial LIPSS periodicity. Along with the insight onto the physical picture driving the morphology evolution and supra‐wavelength nanostructure formation, this experiments also demonstrated that resulting quasi‐regular and random spiky morphology can be tailored by the intensity/polarization distribution of incident laser beam allowing on‐demand surface nanotexturing with diverse hierarchical surface morphologies exhibiting reduced reflectivity at visible and shortwave‐IR wavelengths. Finally, the practical attractiveness of the suggested approach for improving near‐IR photoresponse and expanding operation spectral range of vertical p‐n junction Si photodetector operating under room temperature and zero‐bias conditions via single‐step annealing‐free nanopatterning is highlighted.
Integrated CPU Monitoring Using 2D Temperature Sensor Arrays Directly Printed on Heat Sinks
Authors: Huber Robert , Belles Daniel , Bücher Tim , Franke Leonard , Amrouch Hussam , Lemmer Uli 
Published: March 2024

AbstractIn today's digital world, the demand for computer security and system reliability is a crucial element. Monitoring the CPU temperature during operation provides valuable insights but is currently limited to the embedded on‐chip sensors. The implementation of an extra security layer based on temperature monitoring can detect anomalies in an early stage, identify malware, and help mitigate attacks. The approach of integrating more on‐chip temperature sensors into the silicon is avoided due to space, power limitations, and cost constraints. However, the field of printed electronics and sensor technology has recently seen significant progress. This is the first work that introduces a fully‐printed temperature sensor array integrated onto the cooling unit of a CPU. It offers a novel approach for the practical implementation of such sensors into an operational computer system. The present sensor array, consisting of 396 sensor pixels, detects local hotspots induced by the underneath CPU cores, leading to an individual thermal fingerprint. This unique method paves the way for addressing pivotal elements of computer security, as deviations from expected thermal behavior can signal malicious activities. Additionally, this innovation facilitates reliability optimization. The detailed thermal map garnered provides insights into which cores are subjected to significant stress over time.
Protective action in the workplace in the time of COVID‐19: The role of worker representation
Authors: Ollé‐Espluga Laia , Payá Castiblanque Raúl , Llorens‐Serrano Clara , Esteve‐Matalí Laura , Navarro‐Giné Albert 
Published: March 2024

AbstractBackgroundThis study addresses the contribution of worker representation to health and safety in the pandemic context. To do so, we examine whether the self‐reported presence of representatives in workplaces is associated with the implementation of anti‐COVID‐19 protective action and with which type of measures their existence is most strongly associated (individual, collective or organizational). The article also explores how the presence of worker representatives and anti‐COVID‐19 protective measures are distributed according to workers' socio‐professional characteristics and company features.MethodsThis is a cross‐sectional study based on an online survey conducted in Spain (n = 19,452 workers). Multiple Correspondence Analysis was used for the multivariate description while the association between worker representation and protective measures was assessed by robust Poisson regressions.ResultsThe maps resulting from the Multiple Correspondence Analysis allow for the identification of patterns of inequalities in protection, with a clear occupational social class divide. The regression models show that protective measures are applied more frequently where worker representatives exist, this association being particularly strong in relation to organizational measures.ConclusionsThe presence of worker representation is systematically associated with a greater presence of protective measures, which could have implications for the reduction of social inequalities resulting from labor‐management practices.
Total Synthesis of Lobatamides A and C
Authors: Yasui Soichiro , Banjo Shona , Nagashima Yoshiyuki , Okada Yuto , Yoshikawa Kao , Nakata Keisuke , Chida Noritaka , Okamura Toshitaka , Sato Takaaki 
Published: March 2024

AbstractThe total synthesis of lobatamides A (1 a) and C (1 c) via a common bislactone intermediate is reported. The allylic aryl moiety including a trisubstituted Z‐olefin was constructed by hydroboration of a 1,1‐disubstituted allene and subsequent Migita‐Kosugi‐Stille coupling. Although the seco acid proved to be highly unstable even in the presence of weak bases, Zhao macrolactonization under acidic conditions via the α‐acyloxyenamide successfully provided the common bislactone intermediate. Hydrozirconation‐iodination of the terminal alkyne and subsequent copper‐mediated coupling with primary amides proceeded successfully in the presence of the sensitive bislactone framework. The developed synthetic route enables the late‐stage installation of enamide side chains, which are crucial structures for V‐ATPase inhibition.
Motion and interaction of in‐line bubbles in quiescent non‐aqueous solutions of hydrocarbon resin
Authors: Mei Li , Luo Denghan , Zhang Zhongyao , Chen Xiaopeng , Huang Lifang , Liang Jiezhen , Wei Xiaojie , Liu Bei , Wang Linlin 
Published: March 2024

AbstractHydrocarbon resin (HR) is an essential fine chemical. The preparation and application process of HR involves lots of gas–liquid heterogeneous reactions, and the bubbly flow behavior influences them significantly. Using high‐speed photography and digital image processing techniques, the motion and interaction of in‐line bubbles in non‐aqueous solutions of HR are examined in this article. The results show a critical gas flow rate that can change the bubbling regime. It can be observed that viscosity features prominently in changing the shape of bubbles and their motion. As the viscosity increases, the bubbles are more prone to coalescence, and the bubble coalescence process gradually changes from connected slip‐rising coalescence to connected‐rising coalescence. The viscosity transition region between non‐coalescent and coalescent systems in non‐aqueous solutions of HR occurs at 3.6–9.2 mPa·s. Further, a force analysis shows that in paired bubbles, the leading bubble can be viewed as an individual bubble unaffected by trailing bubble before the two bubbles collide, but in the wake of the leading bubble, the drag force on the trailing bubble decreases and the added mass force increases.
Improving dye removal ability and fouling resistance of thin‐film nanocomposite nanofiltration membranes using a new citric acid functionalized FSM‐16 mesoporous
Authors: Mohammadifar Ashkan , Rahimi Masoud , Zinadini Sirus 
Published: March 2024

AbstractThe development of superior thin‐film nanocomposite (TFN) membranes with good separation performance and anti‐fouling capacity is required to address the larger‐scale freshwater need. In this study, a new citric acid‐functionalized FSM‐16 (CA‐FSM‐16) mesoporous was successfully synthesized and characterized. Subsequently, it was introduced on the surface of the sodium hydroxide/cyanuric chloride‐activated PES membrane to fabricate the CA‐FSM‐16 TFN membrane. It was investigated how various CA‐FSM‐16 loadings affected the overall physicochemical characteristics and performance of the membrane. The SEM analysis confirmed the TFN structure of the fabricated membranes. All manufactured membranes displayed improved hydrophilicity and flux. For the pristine membrane, the salt (Na2SO4) rejection was measured 73.20 ± 2.10%, whereas for the TFN‐0.08 membrane, it was measured 91.40 ± 1.80%. The dye rejection experiment in cross‐flow filtration showed that the TFN‐0.08 membrane had the maximum licorice retention among the membranes (99.10 ± 2.00%). In addition, the CA‐FSM‐16 TFN membranes demonstrated superior antifouling performance, especially the optimum membrane (TFN‐0.08), which showed a high flux recovery ratio (FRR) of 97.10 ± 1.90% and a low irreversible fouling ratio (DRir) of 2.90%. The introduction of CA‐FSM‐16 on the surface of the PES membrane via the surface modification method was a potentially useful technology to fabricate a high‐performing TFN membrane for water treatment applications.
An ethical framework for geophysical survey in historic Black cemeteries
Authors: Lowry Sarah 
Published: March 2024

AbstractHistoric Black cemeteries in the south‐eastern United States are actively threatened by development, neglect, environmental degradation and vandalism. Geophysical archaeological tools are often championed as a solution to document unmarked graves, determine cemetery boundaries and help preserve these spaces. This process can be problematic as geophysical instruments themselves do not find graves; rather, the data collected are reviewed by a skilled professional to interpret where graves might be present. Archaeological geophysical practitioners thus hold a great responsibility to conduct themselves in an ethical manner. Important considerations include archaeological ethics, professionalism and honest communication, as well as centring the needs of preservation within the communities of descendants and stakeholders, if possible, in the way we process, interpret and communicate results.
Exploring enigmas: Information seeking after exposure to virtual reality awe elicitors
Authors: Urban Alex , Bossaller Jenny Simpson 
Published: March 2024

AbstractBecause of awe's properties as a knowledge emotion, awe elicitors can increase awareness of knowledge gaps, boost scientific interest, and promote inquiry. However, the relationship between awe and exploratory behavior, such as information seeking, remains unclear. Using a multi‐method approach, this study asked how and to what extent awe fosters information seeking. This question was examined through a two‐pronged approach. First, in a laboratory setting, participants (n = 32) were exposed to a variety of awe elicitors through a virtual reality (VR) head‐mounted display. Participants' quantitative and qualitative responses were gathered immediately after exposure in the laboratory as well as 24 h later through questionnaires. Second, after establishing a stratified sample of participants who voluntarily conducted information seeking (n = 8), the study shifted to phenomenologically‐informed interviews. This study found that exposure to specific VR scenes piqued participants' curiosity, especially toward representations of phenomena with unknown or unexplained origins. However, self‐motivated exploration only occurred in limited circumstances, particularly toward awe elicitors tinged with supernatural causality. In sum, this study introduces a new research direction within information science, illustrates how understudied awe elicitors pique curiosity, and provides a nuanced, qualitative report on the phenomenon of technology‐induced awe.
Surface Nitriding Enables Improved Intercalation Pseudocapacitance of T−Nb2O5 for Lithium‐Ion Batteries
Authors: Fang Wei , Zhang Lingling , Yang Ming , Zhang Hongyuan , Wu Lina , Dong Enjie , Xiao Xiangjun , Zhang Yan , Lou Shuaifeng , Yin Geping 
Published: March 2024

AbstractThe low electrical conductivity limits the application of T−Nb2O5 as anode materials for practical applications. The large‐grain T−Nb2O5 nanowires with nitrogen doping are obtained by simple hydrothermal and annealing treatments. After nitriding with ammonia, an amorphous layer of NbON as an intermediate is formed and then the new crystalline NbN is generated with the deepening of the nitriding degree, causing homogeneous pores on the surface of the T−Nb2O5 and thus increasing the specific surface area. Meanwhile, the formation of the nitriding layer enhances the electrical conductivity, inducing a pseudo‐capacitance mechanism. Therefore, the N−T−Nb2O5 nanowire demonstrates superior electrochemical performance. Specifically, the 45N−T−Nb2O5 nanowires delivered a first reversible specific capacity of 238.33 mAh g−1 at 0.1 C, higher than of theoretical capacity (201.6 mAh g−1). However, the excessive nitride will be completely converted into NbN, reducing the initial lithium storage of the material due to the lack of a lithium storage site, which has not been previously discussed. Besides, at the high rate of 100 C, with the deepening of nitride degree of the T−Nb2O5, the higher the rate performance. Therefore, to find the balance between the high rate performance and the initial lithium storage amount, the nitride degree should be strictly controlled.
The quantum mechanics of skincare: A context for the biochemistry curriculum
Authors: McPherson Peter A. C. , Alphonso Lynsey , Johnston Ben M. 
Published: March 2024

AbstractDesigning a relevant and engaging curriculum for biochemistry undergraduates can be challenging for topics which are at the periphery of the subject. We have used the framework of context‐based learning as a means of assessing understanding of quantum theory in a group of students in their junior year. Our context, the role of retinol in skincare, provides a basis for the simple application of quantum mechanical principles to a biological context in an adaptation of the polyene in a box concept. As part of the learner journey, they gain experience of practical computational chemistry, which provided an in silico alternative to traditional laboratory work during the SARS‐CoV‐19 pandemic. Student feedback was overwhelmingly positive, and this approach is now firmly embedded in the undergraduate curriculum.
How consumers' economic and psychological vulnerabilities impact their consumption regulation during crisis
Authors: Karaosmanoglu Elif , Okan Mehmet , Işıksal Didem Gamze , Altinigne Nesenur , Demir Ozge , İdemen Elif 
Published: March 2024

AbstractThis paper focuses on the economic and psychological vulnerabilities that are intensified due to the effects of the COVID‐19 pandemic on individuals' health, education and living standards. The deteriorating mental and financial conditions of individuals, called psychological and economic vulnerability, have made an impact on consumers' consumption patterns and habits. This study has proposed that when consumer vulnerabilities increase, consumers will be more likely to express prosocial behaviours and assume higher social capital change that may influence their consumption regulations. The findings are based on a panel survey of 786 individuals via CATI in two waves of data collection in Türkiye (Wave I: 20 July–10 August 2020; Wave II: 20 November–10 December 2020). In Wave I, it is found that when individuals face economic and psychological vulnerability, their tendency to show prosocial behaviour is negatively affected. In Wave II, when the COVID‐19 cases peaked, while economic vulnerability still leads to lower prosocial behaviour, psychological vulnerability gets reversed and results in higher prosocial behaviour. Interestingly, in both waves, when consumers perceive positive social capital change due to increased prosocial behaviour, they are less likely to show consumption regulation.
An introduction to rural minority‐serving community colleges
Authors: Rockey Marci , Collins Jasmine D. 
Published: March 2024

AbstractRacially minoritized communities in rural areas experience some of the most challenging conditions related to poverty, educational access, and educational attainment in the nation (Farrigan, 2021; Hillman, 2016). For residents in these communities, community colleges are the most common entry point into postsecondary education (Byun et al., 2017), yet little attention has been paid to the many two‐year institutions that are both rural and minority‐ serving. This chapter introduces the landscape of rural, minority‐serving community colleges (RMSCCs) and offers future directions for research and practice to bring more visibility to these essential institutions.
Legionella‐induced dysarthria and rhabdomyolysis with acute renal failure achieving recovery
Authors: El Sharu Husam , Ahmad Soban , Coore Hunter 
Published: March 2024

Key Clinical MessageLegionnaires' disease, often presenting as pneumonia, can uncommonly manifest with extrapulmonary symptoms such as cerebellar involvement and rhabdomyolysis. This case emphasizes the successful resolution of dysarthria and renal dysfunction with prompt Legionella treatment, underscoring the importance of vigilance for diverse manifestations in Legionella infections.AbstractLegionnaires' disease usually presents with pneumonia and a few extrapulmonary manifestations, such as neurological, musculoskeletal, and cutaneous manifestations. However, cerebellar involvement and rhabdomyolysis as an association with Legionella are not frequently encountered. We present a case of Legionella‐induced rhabdomyolysis requiring hemodialysis and dysarthria that resolved with Legionella treatment.