bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deterioration Models and Service Life Prediction of Vertical Assets of Urban Water Systems
Authors: Cabral M. , Loureiro D. , Amado C. , Covas D. 
Published: April 2024

AbstractThis study proposes a methodology for developing deterioration models and predicting the service lives of vertical assets of urban water systems (i.e., water storage tanks and pumping stations) using regression analysis. The main factors contributing to the deterioration of these assets are analyzed. Simple and multiple linear regression models of average and maximum deterioration are calculated for 22 water storage tanks and 17 wastewater pumping stations. Data on a set of four water storage tanks are used to validate the developed deterioration models. Service life prediction is carried out using the developed models and considering two maximum deterioration levels: the maximum recommended and admissible deterioration levels. Two water storage tanks are further studied to illustrate and discuss the effect of maintenance and rehabilitation interventions on asset service life by comparing the asset deterioration before and after the interventions. Results include simple linear regression models of average and maximum deterioration indices as a function of asset age and multiple linear regression models that incorporate other physical, operational and environmental factors. The results show that simple linear regression models of asset deterioration show a better predictive power than multiple regression models. Despite the higher data variability of multiple regression models, these models allow to include the random process of asset deterioration, through the calculation of the standard deviation. This study also shows that periodic interventions are a preferable maintenance and rehabilitation strategy over major sporadic rehabilitation interventions since it allows to maintain assets in good condition and to extend their service life almost indefinitely.
Benefit of Multivariate Model Calibration for Different Climatic Regions
Authors: Pool S. , Fowler K. , Peel M. 
Published: April 2024

AbstractHydrological models are traditionally calibrated against observed discharge. However, for a given model, similar performance for discharge simulation can be achieved through a variety of parameter combinations, some of which produce unrealistic simulations of non‐discharge variables. Thus, considering non‐discharge variables in calibration can help to reduce equifinality and give more realistic simulations. Few studies considered non‐discharge variables in calibration and evaluation and across a large sample of catchments. In this study, we calibrate the lumped SIMHYD model with several combinations of different hydrological variables such as discharge, actual evapotranspiration, soil wetness, and total water storage. The various calibration scenarios are conducted across 550 catchments in Australia spanning arid, tropical and temperate regions. We show that the performance of the discharge‐calibrated model for actual evapotranspiration, soil wetness, and total water storage is strongly related to the co‐seasonality of discharge and the respective variable. Considering actual evapotranspiration, soil wetness, or total water storage in addition to discharge in calibration improves the simulation of the added variable on average by 53%, 58%, and 41%, respectively, which comes at the expense of decrease in discharge performance by 5%. Cross‐benefits, that is, the improved simulation of a variable by considering another variable in calibration, mainly occurs between actual evapotranspiration and total water storage and are most pronounced in humid catchments with highly seasonal soil wetness. We also find that when using all four variables in model calibration, the trade‐off in model performance between discharge and the other variables gets more pronounced with increasing catchment wetness.
Counter‐Helical Magnetic Flux Ropes From Magnetic Reconnections in Space Plasmas
Authors: Jia Ying‐Dong , Qi Yi , Wang Xueyi , Miles Nathan , Russell C. T. , Wei Hanying 
Published: April 2024

AbstractMagnetic flux ropes are ubiquitous in various space environments, including the solar corona, interplanetary solar wind, and planetary magnetospheres. When these flux ropes intertwine, magnetic reconnection may occur at the interface, forming disentangled new ropes. Some of these newly formed ropes contain reversed helicity along their axes, diverging from the traditional flux rope model. We introduce new observations and interpretations of these newly formed flux ropes from existing Hall Magnetohydrodynamics model results. We first examine the time‐varying local magnetic field direction at the impact interface to assess the likelihood of reconnection. Then we investigate the electric current system to describe the evolution of these structures, which potentially accelerate particles and heat the plasma. This study offers novel insights into the dynamics of space plasmas and suggests a potential solar wind heating source, calling for further synthetic observations.
Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
Authors: Parmasad Jean-Louis A. , Ricke Konrad M. , Nguyen Benjamin , Stykel Morgan G. , Buchner-Duby Brodie , Bruce Amanda , Geertsma Haley M. , Lian Eric , Lengacher Nathalie A. , Callaghan Steve M. , Joselin Alvin , Tomlinson Julianna J. , Schlossmacher Michael G. , Stanford William L. , Ma Jiyan , Brundin Patrik , Ryan Scott D. , Rousseaux Maxime W. C. 
Published: April 2024

AbstractParkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor halt the progression of PD. Multiplications and mutations of the α-Syn gene (SNCA) cause PD-associated syndromes and animal models that overexpress α-Syn replicate several features of PD. Decreasing total α-Syn levels, therefore, is an attractive approach to slow down neurodegeneration in patients with synucleinopathy. We previously performed a genetic screen for modifiers of α-Syn levels and identified CDK14, a kinase of largely unknown function as a regulator of α-Syn. To test the potential therapeutic effects of CDK14 reduction in PD, we ablated Cdk14 in the α-Syn preformed fibrils (PFF)-induced PD mouse model. We found that loss of Cdk14 mitigates the grip strength deficit of PFF-treated mice and ameliorates PFF-induced cortical α-Syn pathology, indicated by reduced numbers of pS129 α-Syn-containing cells. In primary neurons, we found that Cdk14 depletion protects against the propagation of toxic α-Syn species. We further validated these findings on pS129 α-Syn levels in PD patient neurons. Finally, we leveraged the recent discovery of a covalent inhibitor of CDK14 to determine whether this target is pharmacologically tractable in vitro and in vivo. We found that CDK14 inhibition decreases total and pathologically aggregated α-Syn in human neurons, in PFF-challenged rat neurons and in the brains of α-Syn-humanized mice. In summary, we suggest that CDK14 represents a novel therapeutic target for PD-associated synucleinopathy.
Low thermal contact resistance boron nitride nanosheets composites enabled by interfacial arc-like phonon bridge
Authors: Zhan Ke , Chen Yucong , Xiong Zhiyuan , Zhang Yulun , Ding Siyuan , Zhen Fangzheng , Liu Zhenshi , Wei Qiang , Liu Minsu , Sun Bo , Cheng Hui-Ming , Qiu Ling 
Published: April 2024

AbstractTwo-dimensional materials with ultrahigh in-plane thermal conductivity are ideal for heat spreader applications but cause significant thermal contact resistance in complex interfaces, limiting their use as thermal interface materials. In this study, we present an interfacial phonon bridge strategy to reduce the thermal contact resistance of boron nitride nanosheets-based composites. By using a low-molecular-weight polymer, we are able to manipulate the alignment of boron nitride nanosheets through sequential stacking and cutting, ultimately achieving flexible thin films with a layer of arc-like structure superimposed on perpendicularly aligned ones. Our results suggest that arc-like structure can act as a phonon bridge to lower the contact resistance by 70% through reducing phonon back-reflection and enhancing phonon coupling efficiency at the boundary. The resulting composites exhibit ultralow thermal contact resistance of 0.059 in2 KW−1, demonstrating effective cooling of fast-charging batteries at a thickness 2-5 times thinner than commercial products.
Context-aware deep learning enables high-efficacy localization of high concentration microbubbles for super-resolution ultrasound localization microscopy
Authors: Shin YiRang , Lowerison Matthew R. , Wang Yike , Chen Xi , You Qi , Dong Zhijie , Anastasio Mark A. , Song Pengfei 
Published: April 2024

AbstractUltrasound localization microscopy (ULM) enables deep tissue microvascular imaging by localizing and tracking intravenously injected microbubbles circulating in the bloodstream. However, conventional localization techniques require spatially isolated microbubbles, resulting in prolonged imaging time to obtain detailed microvascular maps. Here, we introduce LOcalization with Context Awareness (LOCA)-ULM, a deep learning-based microbubble simulation and localization pipeline designed to enhance localization performance in high microbubble concentrations. In silico, LOCA-ULM enhanced microbubble detection accuracy to 97.8% and reduced the missing rate to 23.8%, outperforming conventional and deep learning-based localization methods up to 17.4% in accuracy and 37.6% in missing rate reduction. In in vivo rat brain imaging, LOCA-ULM revealed dense cerebrovascular networks and spatially adjacent microvessels undetected by conventional ULM. We further demonstrate the superior localization performance of LOCA-ULM in functional ULM (fULM) where LOCA-ULM significantly increased the functional imaging sensitivity of fULM to hemodynamic responses invoked by whisker stimulations in the rat brain.
The CRISPR-Cas13a Gemini System for noncontiguous target RNA activation
Authors: Zhao Hongrui , Sheng Yan , Zhang Tenghua , Zhou Shujun , Zhu Yuqing , Qian Feiyang , Liu Meiru , Xu Weixue , Zhang Dengsong , Hu Jiaming 
Published: April 2024

AbstractSimultaneous multi-target detection and multi-site gene editing are two key factors restricting the development of disease diagnostic and treatment technologies. Despite numerous explorations on the source, classification, functional features, crystal structure, applications and engineering of CRISPR-Cas13a, all reports use the contiguous target RNA activation paradigm that only enables single-target detection in vitro and one-site gene editing in vivo. Here we propose a noncontiguous target RNA activation paradigm of Cas13a and establish a CRISPR-Cas13a Gemini System composed of two Cas13a:crRNA binary complexes, which can provide rapid, simultaneous, highly specific and sensitive detection of two RNAs in a single readout, as well as parallel dual transgene knockdown. CRISPR-Cas13a Gemini System are demonstrated in the detection of two miRNAs (miR-155 and miR-375) for breast cancer diagnosis and two small RNAs (EBER-1 and EBER-2) for Epstein-Barr virus diagnosis using multiple diagnostic platforms, including fluorescence and colorimetric-based lateral flow systems. We also show that CRISPR-Cas13a Gemini System can knockdown two foreign genes (EGFP and mCherry transcripts) in mammalian cells simultaneously. These findings suggest the potential of highly effective and simultaneous detection of multiple biomarkers and gene editing of multiple sites.
Crosslinking-induced patterning of MOFs by direct photo- and electron-beam lithography
Authors: Tian Xiaoli , Li Fu , Tang Zhenyuan , Wang Song , Weng Kangkang , Liu Dan , Lu Shaoyong , Liu Wangyu , Fu Zhong , Li Wenjun , Qiu Hengwei , Tu Min , Zhang Hao , Li Jinghong 
Published: April 2024

AbstractMetal-organic frameworks (MOFs) with diverse chemistry, structures, and properties have emerged as appealing materials for miniaturized solid-state devices. The incorporation of MOF films in these devices, such as the integrated microelectronics and nanophotonics, requires robust patterning methods. However, existing MOF patterning methods suffer from some combinations of limited material adaptability, compromised patterning resolution and scalability, and degraded properties. Here we report a universal, crosslinking-induced patterning approach for various MOFs, termed as CLIP-MOF. Via resist-free, direct photo- and electron-beam (e-beam) lithography, the ligand crosslinking chemistry leads to drastically reduced solubility of colloidal MOFs, permitting selective removal of unexposed MOF films with developer solvents. This enables scalable, micro-/nanoscale (≈70 nm resolution), and multimaterial patterning of MOFs on large-area, rigid or flexible substrates. Patterned MOF films preserve their crystallinity, porosity, and other properties tailored for targeted applications, such as diffractive gas sensors and electrochromic pixels. The combined features of CLIP-MOF create more possibilities in the system-level integration of MOFs in various electronic, photonic, and biomedical devices.
De novo design of pH-responsive self-assembling helical protein filaments
Authors: Shen Hao , Lynch Eric M. , Akkineni Susrut , Watson Joseph L. , Decarreau Justin , Bethel Neville P. , Benna Issa , Sheffler William , Farrell Daniel , DiMaio Frank , Derivery Emmanuel , De Yoreo James J. , Kollman Justin , Baker David 
Published: April 2024

AbstractBiological evolution has led to precise and dynamic nanostructures that reconfigure in response to pH and other environmental conditions. However, designing micrometre-scale protein nanostructures that are environmentally responsive remains a challenge. Here we describe the de novo design of pH-responsive protein filaments built from subunits containing six or nine buried histidine residues that assemble into micrometre-scale, well-ordered fibres at neutral pH. The cryogenic electron microscopy structure of an optimized design is nearly identical to the computational design model for both the subunit internal geometry and the subunit packing into the fibre. Electron, fluorescent and atomic force microscopy characterization reveal a sharp and reversible transition from assembled to disassembled fibres over 0.3 pH units, and rapid fibre disassembly in less than 1 s following a drop in pH. The midpoint of the transition can be tuned by modulating buried histidine-containing hydrogen bond networks. Computational protein design thus provides a route to creating unbound nanomaterials that rapidly respond to small pH changes.
Circular design strategies and economic sustainability of construction projects in china: the mediating role of organizational culture
Authors: Chen You , Yin Xiaomin , Lyu Chunwei 
Published: April 2024

AbstractThis research aims to elucidate the relationship between circular design strategies (CDS) and the economic sustainability of construction projects (ESCP), examining the mediating role of organizational culture (OC). Motivated by the imperative to develop a sustainable circular economy (CE) model in the building industry, our study focuses on a crucial dimension of CE processes. Specifically, we investigate how construction firms’ organizational values shape their pursuit of desired economic outcomes within CE theory. Through a comprehensive analysis of 359 responses from a cross-sectional survey of Chinese construction firms employing Partial Least Squares-Structural Equation Modeling (PLS-SEM), our findings reveal a positive albeit weakly impactful association between CDS and ESCP. Simultaneously, OC is identified as a factor detrimental to ESCP. Notably, this study unveils the influential roles of hierarchical culture (HC) and group culture (GC) in shaping the current state of ESCP in China. Emphasizing the significance of CDS, we propose that contract administrators proactively reposition their organizations to adopt strategies conducive to achieving the necessary economic output for construction projects. The originality aspect lies in this research contributes to the existing body of knowledge by offering empirical insights into the theoretical framework, marking the first such empirical study in northern China. We conclude by critically examining research outcomes and limitations while providing insightful recommendations for future research to foster sustainable construction practices in the Chinese context.
In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study
Authors: Brogini Silvia , Crovace Alberto , Piccininni Antonio , Serratore Giuseppe , Marchiori Gregorio , Maglio Melania , Guglielmi Pasquale , Cusanno Angela , De Napoli Luigi , Conte Romina , Fini Milena , Ambrogio Giuseppina , Palumbo Gianfranco , Giavaresi Gianluca 
Published: April 2024

AbstractCranial reconstructions are essential for restoring both function and aesthetics in patients with craniofacial deformities or traumatic injuries. Titanium prostheses have gained popularity due to their biocompatibility, strength, and corrosion resistance. The use of Superplastic Forming (SPF) and Single Point Incremental Forming (SPIF) techniques to create titanium prostheses, specifically designed for cranial reconstructions was investigated in an ovine model through microtomographic and histomorphometric analyses. The results obtained from the explanted specimens revealed significant variations in bone volume, trabecular thickness, spacing, and number across different regions of interest (VOIs or ROIs). Those regions next to the center of the cranial defect exhibited the most immature bone, characterized by higher porosity, decreased trabecular thickness, and wider trabecular spacing. Dynamic histomorphometry demonstrated differences in the mineralizing surface to bone surface ratio (MS/BS) and mineral apposition rate (MAR) depending on the timing of fluorochrome administration. A layer of connective tissue separated the prosthesis and the bone tissue. Overall, the study provided validation for the use of cranial prostheses made using SPF and SPIF techniques, offering insights into the processes of bone formation and remodeling in the implanted ovine model.
Darcy Forchhiemer imposed exponential heat source-sink and activation energy with the effects of bioconvection over radially stretching disc
Authors: Nihaal K. M. , Mahabaleshwar U. S. , Joo S. W. 
Published: April 2024

AbstractThe Darcy–Forchheimer model is a commonly used and accurate method for simulating flow in porous media, proving beneficial for fluid separation, heat exchange, subsurface fluid transfer, filtration, and purification. The current study aims to describe heat and mass transfer in ternary nanofluid flow on a radially stretched sheet with activation energy. The velocity equation includes Darcy–Fochheimer porous media effects. The novelty of this study is enhanced by incorporating gyrotactic microorganisms which are versatile and in nanofluid can greatly improve the thermal conductivity and heat transfer properties of the base fluid, resulting in more efficient heat transfer systems. Furthermore, the governing PDEs are reduced to ODEs via appropriate similarity transformations. The influence of numerous parameters is expanded and physically depicted through the graphical illustration. As the Forchheimer number escalates, so do the medium's porosity and drag coefficient, resulting in more resistive forces and, as a result, lowering fluid velocity. It has been discovered that increasing the exponential heat source/sink causes convective flows that are deficient to transport heat away efficiently, resulting in a slower heat transfer rate. The concentration profile accumulates when the activation energy is large, resulting in a drop in the mass transfer rate. It is observed that the density of motile microorganisms increases with a rise in the Peclet number. Further, the results of the major engineering coefficients Skin-friction, Nusselt number, Sherwood number, and Microorganism density number are numerically examined and tabulated. Also, the numerical outcomes were found to be identical to the previous study.
Development and validation of a questionnaire for assessing visual and auditory spatial localization abilities in dual sensory impairment
Authors: Xiong Yingzi , Nemargut Joseph Paul , Bradley Chris , Wittich Walter , Legge Gordon E. 
Published: April 2024

AbstractSpatial localization is important for social interaction and safe mobility, and relies heavily on vision and hearing. While people with vision or hearing impairment compensate with their intact sense, people with dual sensory impairment (DSI) may require rehabilitation strategies that take both impairments into account. There is currently no tool for assessing the joint effect of vision and hearing impairment on spatial localization in this large and increasing population. To this end, we developed a novel Dual Sensory Spatial Localization Questionnaire (DS-SLQ) that consists of 35 everyday spatial localization tasks. The DS-SLQ asks participants about their difficulty completing different tasks using only vision or hearing, as well as the primary sense they rely on for each task. We administered the DS-SLQ to 104 participants with heterogenous vision and hearing status. Rasch analysis confirmed the psychometric validity of the DS-SLQ and the feasibility of comparing vision and hearing spatial abilities in a unified framework. Vision and hearing impairment were associated with decreased visual and auditory spatial abilities. Differences between vision and hearing abilities predicted overall sensory reliance patterns. In DSI rehabilitation, DS-SLQ may be useful for measuring vision and hearing spatial localization abilities and predicting the better sense for completing different spatial localization tasks.
Effectiveness of stress arousal reappraisal and stress-is-enhancing mindset interventions on task performance outcomes: a meta-analysis of randomized controlled trials
Authors: Bosshard Michel , Gomez Patrick 
Published: April 2024

AbstractStress arousal reappraisal (SAR) and stress-is-enhancing (SIE) mindset interventions aim to promote a more adaptive stress response by educating individuals about the functionality of stress. As part of this framework, an adaptive stress response is coupled with improved performance on stressful tasks. The goal of this meta-analysis is to evaluate the effectiveness of these interventions on task performance. The literature search yielded 44 effect sizes, and a random-effects model with Knapp-Hartung adjustment was used to pool them. The results revealed an overall small significant improvement in task performance (d = 0.23, p < 0.001). The effect size was significantly larger for mixed interventions (i.e., SAR/SIE mindset instructions combined with additional content, k = 5, d = 0.45, p = 0.004) than SAR-only interventions (k = 33, d = 0.22, p < 0.001) and SIE mindset-only interventions (k = 6, d = 0.18, p = 0.22) and tended to be larger for public performance tasks than cognitive written tasks (k = 14, d = 0.34, p < 0.001 vs. k = 30, d = 0.20, p = 0.002). Although SAR and SIE mindset interventions are not “silver bullets”, they offer a promising cost-effective low-threshold approach to improve performance across various domains.