bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Antara Kejenuhan Kerja (Burnout) dengan Motivasi Kerja Pada Perawat Pelaksana
Authors: Diyanto Velani Prastika , Supratman Supratman 
Published: February 2024

ABSTRACT Nurses are an important component in realizing quality health services, apart from that, nurses have medical services that have been recognized by the government. Nurses are in all units in the hospital, one of which is in the inpatient unit. The aim of this research is to determine the relationship between burnout and work motivation in executive nurses. Utilizing probability sampling techniques, the approach is quantitative. A total of 110 people participated in the study. The Maslach Burnout Inventory-Human Service Survey (MBI-HSS) questionnaire, which consists of 22 questions in the form of a Likert model scale with response options ranging from 1 to 4, is the tool utilized in this study. 1 denotes never, 2 seldom, 3 frequently, and 4 constantly. The study's findings indicate a strong correlation between implementation nurses work motivation and burnout. It can be concluded that the majority of nurse respondents at RSUD Dr. Moewardi is in the 30-40 year age range, which is considered a productive period with a high level of productivity. Keywords: Burnout, Executive Nurses, Work Motivation ABSTRAK Selain berperan penting dalam penyediaan layanan kesehatan berkualitas tinggi, perawat juga memiliki spesialisasi medis yang diakui secara resmi. Setiap unit rumah sakit, termasuk bangsal rawat inap, memiliki staf perawat. Tujuan penelitian ini adalah mengetahui Hubungan Antara Kejenuhan Kerja (Burnout) Dengan Motivasi Kerja Pada Perawat Pelaksana. Metode yang digunakan adalah kuantitatif dengan teknik probability sampling. Responden yang diteliti berjumlah 110 responden. Penelitian ini menggunakan kuesioner Maslach Burnout Inventory-Human Service Survey (MBI-HSS) yang terdiri dari 22 pertanyaan dengan skala model Likert dengan pilihan jawaban berkisar antara 1 sampai 4. 1 menunjukkan tidak pernah, 2 jarang, 3 sering, dan 4 terus-menerus. Temuan penelitian menunjukkan bahwa kelelahan dan motivasi penerapan perawat dalam pekerjaannya berkorelasi secara signifikan. Dapat disimpulkan bahwa sebagian besar responden perawat di RSUD Dr. Moewardi berada pada rentang usia 30-40 tahun, yang dianggap masa produktif dengan tingkat produktivitas yang tinggi. Kata kunci: Kejenuhan Kerja, Motivasi Kerja, Perawat Pelaksana
Efektivitas Media Lembar Balik Terhadap Tingkat Pengetahuan dan Sikap Ibu dalam Pemberian MP-ASI
Authors: Hasanah Devi Miftahul , Lesmana Hendy 
Published: February 2024

ABSTRACT Toddlers in the developing phase of growth and development are more susceptible to health issues arising from dietary deficiencies. Optimal nutrition during the early stages of life significantly influences the child's physical, cognitive, and social development. Parental variables associated with nutritional issues in toddlers encompass parental education and occupation and mother knowledge, attitudes, and behavior about nutrition. To enhance maternal knowledge, it is necessary to develop health education programs that promote awareness and understanding of health requirements. This will facilitate the adoption of healthy behaviors. This study aims to assess the efficacy of flip-sheet media in enhancing the knowledge and attitudes of mothers in delivering weaning food. The research approach employed in this study is quantitative, utilizing a Quasi-Experimental design with a post-test-only Control Group Design. The sample size for this study consisted of 64 moms with children between the ages of 6 and 24 months. The research consisted of a total sample size of 55 respondents, selected using the Purposive Sampling approach. The Mann-Whitney U test was employed to evaluate the data. This study demonstrates a notable correlation between the knowledge and attitude of mothers in providing weaning food through a flip sheet medium. Future researchers should conduct comparative studies between one health promotion medium and other media. Keywords: Flip-sheets, Weaning Food, Health Education, Mother’s Knowledge and Attitudes ABSTRAK Balita berada pada masa awal pertumbuhan dan perkembangan, maka mereka sangat rentan mengalami gangguan kesehatan akibat masalah gizi. Awal gizi yang baik akan sangat berakibat pada kehidupan yaitu pada perkembangan fisik, kognitif dan sosial anak. Faktor orang tua yang berhubungan dengan masalah gizi pada balita, antara lain pendidikan dan pekerjaan orang tua, serta pengetahuan, sikap, dan perilaku ibu tentang gizi. Upaya untuk meningkatkan pengetahuan ibu perlu dilaksanakan penyuluhan kesehatan untuk meningkatkan pengetahuan dan sikap tentang kebutuhan kesehatan agar mudah terjadinya perilaku sehat. Tujuan penelitian ini adalah menganalisis efektivitas media lembar balik terhadap tingkat pengetahuan dan sikap ibu dalam pemberian MP-ASI. Metode penelitian ini adalah kuantitatif dengan desain Quasi Experimental dengan Post Test Only Control Group Design. Populasi dalam penelitian ini sebanyak 64 ibu yang memiliki balita usia 6-24 bulan. Jumlah sampel penelitian ini adalah 55 responden yang dipilih menggunakan teknik Purposive Sampling. Data dianalisis dengan uji Mann Whitney U. Berdasarkan hasil penelitian ini menunjukkan ada pengaruh yang signifikan antara pengetahuan dan sikap ibu dalam pemberian MP-ASI terhadap media lembar balik. Peneliti selanjutnya direkomendasikan untuk membandingkan salah satu media promosi kesehatan dengan media lainnya. Kata Kunci: Lembar Balik, MP-ASI, Pendidikan Kesehatan, Pengetahuan dan Sikap Ibu
Pengetahuan Remaja Putri tentang Senam Dismenorea Wilayah RT 002 RW 014 Kelurahan Jatibening Tahun 2023
Authors: Anisa Delya , Rahmadyanti Rahmadyanti 
Published: February 2024

ABSTRACT The lack of knowledge among adolescent girls about Dismenorea exercises is a problem that needs attention. Dismenorea, if not properly managed, can disrupt activities and affect mental and physical functions such as weakness, restlessness, depression, severe cramps, and accumulation of menstrual blood in the pelvic cavity. Long-term use of pharmacological treatments can also lead to side effects such as kidney damage and bone thinning. This study aims to evaluate the knowledge of adolescent girls about Dismenorea exercises. The study design is descriptive, with a population consisting of all adolescent girls in Rt 002 Rw 014 of Jatibening Village. The research sample consists of 100 respondents, selected randomly. Data collection was done through a questionnaire. The results of the study show that out of 100 respondents in Rt 002 Rw 014 of Jatibening Village, 34 (34%) respondents have insufficient knowledge, 27 (27%) respondents have sufficient knowledge, and 39 (39%) respondents have good knowledge. Based on the research findings, it can be concluded that the knowledge of adolescent girls in Rt 002 Rw 014 is still lacking. Therefore, further research can explore the factors that contribute to the lack of knowledge among adolescent girls about Dismenorea exercises. Keywords: Knowledge, Adolescent Girls, Dismenorea Exercises ABSTRAK Kurangnya pengetahuan remaja putri tentang senam Dismenorea adalah masalah yang perlu diperhatikan. Dismenore, jika tidak ditangani dengan baik, dapat mengganggu aktivitas dan mempengaruhi fungsi mental dan fisik seperti kelemahan, kegelisahan, depresi, kram yang parah, dan penumpukan darah menstruasi di rongga panggul. Penggunaan pengobatan farmakologis dalam jangka waktu yang lama juga dapat menyebabkan efek samping seperti kerusakan ginjal dan penipisan tulang. Penelitian ini bertujuan untuk mengevaluasi pengetahuan remaja putri tentang senam Dismenorea. Desain penelitian ini bersifat deskriptif, dengan populasi yang terdiri dari semua remaja putri di Wilayah Rt 002 Rw 014 Kelurahan Jatibening. Sampel penelitian terdiri dari 100 responden, yang dipilih secara acak. Pengumpulan data dilakukan melalui kuesioner. Hasil penelitian menunjukkan bahwa dari 100 responden di Wilayah Rt 002 Rw 014 Kelurahan Jatibening, sebanyak 34 (34%) responden memiliki pengetahuan yang kurang, 27 (27%) responden memiliki pengetahuan yang cukup, dan 39 (39%) responden memiliki pengetahuan yang baik. hasil penelitian, dapat disimpulkan bahwa pengetahuan remaja putri di wilayah Rt 002 Rw 014 masih kurang. Oleh karena itu, penelitian selanjutnya dapat mengeksplorasi faktor-faktor apa saja yang menyebabkan kurangnya pengetahuan remaja putri tentang senam Dismenorea. Kata Kunci: Pengetahuan, Remaja Putri, Senam Dismenore
Efektivitas Terapi Musik K-Pop Terhadap Penurunan Tingkat Kecemasan Sebelum Pertunjukan Pada Dancer Remaja di Yapemri Depok
Authors: Fajariyah Nur , Utami Ladies Tri 
Published: February 2024

ABSTRACT Music therapy has the effect of sedation, stimulates the limbic system, which is the system that manages emotions. Anxiety in adolescents arises due to many reasons, such as the fear of failing in doing something, for example when you want to do a dance performance, which can cause excessive worry about failing, things like that can interfere with concentration and will also cause anxiety. Dancers who experience anxiety can affect their appearance before the show, and anxiety can be controlled by relaxing with therapy, one of which is music therapy. To determine the relationship between the effectiveness of K-POP music therapy and the decrease in the anxiety level of young dancers at YAPEMRI Depot. The methodology used in this study is a Quasi-Experimental method, by carrying out complementary therapy, namely music therapy, which is carried out for 15 minutes, and is also carried out regularly for 6 days. From the results of the study it was found that there was effectiveness of K-POP music therapy on reducing anxiety levels before competing in young dancers at YAPEMRI Depot with a value of p=0.000 or p<0.05. This study proved the effectiveness of K-POP music therapy in reducing anxiety levels. Keywords: Music Therapy, Anxiety, Adolescents, Dancer. ABSTRAK Terapi musik memiliki efek yaitu sedasi, merangsang sistem limbik yang dimana sistem ini merupakan yang mengelola emosi. Kecemasan pada remaja timbul akibat banyaknya sebab, seperti takutnya mengalami kegagalan dalam melakukan suatu hal, contohnya saat ingin melakukan pertunjukan tari, yang dapat menimbulkan rasa khawatir yang berlebihan akan mengalami kegagalan, hal seperti itu dapat menggangu konsenterasi dan juga akan menyebakan terjadinya kecemasan. Dancer yang mengalami kecemasan dapat mempengaruhi penampilan sebelum pertunjukan, dan kecemasan dapat dikontrol dengan melakukan relaksasi menggunakan terapi, salah satunya yaitu terapi musik. Mengetahui hubungan efektivitas terapi musik K-POP terhadap penurunan tingkat kecemasan dancer remaja di YAPEMRI Depok. Metodelogi yang digunakan pada penelitian ini merupakan metode Quasi Eksperimental, dengan melakukan terapi komplementer yaitu terapi musik, yang dilakukan selama 15 menit, dan juga dilakukan secara rutin selama 6 hari. Dari hasil penelitian didapatkan bahwa adanya efektivitas terapi musik K-POP terhadap penurunan tingkat kecemasan sebelum bertanding pada dancer remaja di YAPEMRI Depok dengan nilai p=0,000 atau p<0,05. Dalam penelitian ini terbukti adanya efektivitas terapi musik K-POP terhadap penurunan tingkat kecemasan Kata Kunci: Terapi Musik, Kecemasan, Remaja, Penari.
Hubungan Pengetahuan dan Sikap Dengan Pelaksanaan Perawatan Metode Kanguru
Authors: Hanum Parida , Winasis Tyas , Sartika Titin , Tambunan Tia Oktaviani , Hulu Trinias Oktaviani , Siregar Try Hidayati 
Published: February 2024

ABSTRACT The kangaroo method of care is a method that has been proven to reduce the incidence of infections, breastfeeding problems and increase maternal satisfaction and improve the relationship between mother and baby. WHO reports that LBW has a risk of death 20 times greater than babies with normal birth weight. LBW are susceptible to infectious diseases because the body's anti-immune substances are less than perfect. The aim of this research was to determine the relationship between knowledge and attitudes with the implementation of the kangaroo method of care at UPT Puskesmas Sedinginan. This type of research uses descriptive correlation to see a relationship between knowledge and attitudes and the implementation of kangaroo method care. The population in this study were all mothers who gave birth to LBW babies, namely 50 people. The sample in this study was all mothers who gave birth to LBW babies, namely 50 people. Sampling in this study used the Total Sampling technique. Analysis of research data is univariate and bivariate analysis. The results of the research explain that there is a relationship between mother's knowledge and attitudes and the implementation of kangaroo method care with a P value of 0.006. It is hoped that this research suggestion can provide knowledge information to mothers about kangaroo care methods. Keywords: Knowledge, Attitude, Kangaroo Method ABSTRAK Perawatan metode kanguru merupakan salah satu metode yang terbukti dapat menurunkan kejadian infeksi, masalah menyusui dan meningkatkan kepuasan ibu serta meningkatkan hubungan antara ibu dan bayi. WHO melaporkan, BBLR memiliki resiko kematian 20 kali lebih besar dari bayi dengan berat badan lahir normal. BBLR mudah mengalami penyakit infeksi karena zat anti kekebalan tubuh kurang sempurna. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dan sikap dengan pelaksanaan perawatan metode kanguru di UPT Puskesmas Sedinginan. Jenis penelitian ini menggunaan deskriptif korelasi untuk melihat sebuah hubungan antara pengetahuan dan sikap dengan pelaksanaan perawatan metode kanguru. Populasi dalam penelitian ini adalah seluruh ibu yang melahirkan bayi BBLR yaitu sebanyak 50 orang. Sampel dalam penelitian ini adalah seluruh ibu yang melahirkan bayi BBLR yaitu sebanyak 50 orang. Pengambilan sampel pada penelitian ini menggunakan teknik Total Sampling. Analisa data penelitian adalah anlias univariat dan bivariat. Hasil penelitian menjelaskan bahwa ada hubungan antara pengetahuan dan sikap ibu dengan pelaksanaan perawatan metode kanguru di UPT Puskesmas Sedinginan dengan nilai Pvalue 0,006. Saran penelitian ini diharapkan dapat memberikan informasi pengetahuan kepada ibu tentang perawatan metode kanguru. Kata Kunci: Pengetahuan, Sikap, Metode Kanguru
CD8+ NKs as a potential biomarker of complete response and survival with lenalidomide plus R-GDP in the R2-GDP-GOTEL trial in recurrent/refractory diffuse large B cell lymphoma
Authors: Hontecillas-Prieto Lourdes , García-Domínguez Daniel J. , Palazón-Carrión Natalia , Martín García-Sancho Alejandro , Nogales-Fernández Esteban , Jiménez-Cortegana Carlos , Sánchez-León María L. , Silva-Romeiro Silvia , Flores-Campos Rocío , Carnicero-González Fernando , Ríos-Herranz Eduardo , de la Cruz-Vicente Fátima , Rodríguez-García Guillermo , Fernández-Álvarez Rubén , Martínez-Banaclocha Natividad , Gumà-Padrò Josep , Gómez-Codina José , Salar-Silvestre Antonio , Rodríguez-Abreu Delvys , Gálvez-Carvajal Laura , Labrador Jorge , Guirado-Risueño María , Provencio-Pulla Mariano , Sánchez-Beato Margarita , Marylene Lejeune , Álvaro-Naranjo Tomás , Casanova-Espinosa María , Rueda-Domínguez Antonio , Sánchez-Margalet Víctor , de la Cruz-Merino Luis 
Published: February 2024

BackgroundDiffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma worldwide. DLBCL is an aggressive disease that can be cured with upfront standard chemoimmunotherapy schedules. However, in approximately 35-40% of the patients DLBCL relapses, and therefore, especially in this setting, the search for new prognostic and predictive biomarkers is an urgent need. Natural killer (NK) are effector cells characterized by playing an important role in antitumor immunity due to their cytotoxic capacity and a subset of circulating NK that express CD8 have a higher cytotoxic function. In this substudy of the R2-GDP-GOTEL trial, we have evaluated blood CD8+ NK cells as a predictor of treatment response and survival in relapsed/refractory (R/R) DLBCL patients.Methods78 patients received the R2-GDP schedule in the phase II trial. Blood samples were analyzed by flow cytometry. Statistical analyses were carried out in order to identify the prognostic potential of CD8+ NKs at baseline in R/R DLBCL patients.ResultsOur results showed that the number of circulating CD8+ NKs in R/R DLBCL patients were lower than in healthy donors, and it did not change during and after treatment. Nevertheless, the level of blood CD8+ NKs at baseline was associated with complete responses in patients with R/R DLBCL. In addition, we also demonstrated that CD8+ NKs levels have potential prognostic value in terms of overall survival in R/R DLBCL patients.ConclusionCD8+ NKs represent a new biomarker with prediction and prognosis potential to be considered in the clinical management of patients with R/R DLBCL.Clinical trial registrationhttps://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-001620-29 EudraCT, ID:2014-001620-29.
Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases
Authors: Perico Luca , Casiraghi Federica , Sônego Fabiane , Todeschini Marta , Corna Daniela , Cerullo Domenico , Pezzotta Anna , Isnard-Petit Patricia , Faravelli Silvia , Forneris Federico , Thiam Kader , Benigni Ariela , Remuzzi Giuseppe 
Published: February 2024

IntroductionIn autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells. However, current first-line treatments rely on non-specific and general suppression of the immune system, exposing patients to severe side effects. For this reason, identification of targeted therapies for autoimmune diseases is an unmet clinical need.MethodsHere, we designed a novel class of immunotherapeutic molecules, Bi-specific AutoAntigen-T cell Engagers (BiAATEs), as a potential approach for targeting the small subset of autoreactive B cells. To test this approach, we focused on a prototype autoimmune disease of the kidney, membranous nephropathy (MN), in which phospholipase A2 receptor (PLA2R) serves as primary nephritogenic antigen. Specifically, we developed a BiAATE consisting of the immunodominant Cysteine-Rich (CysR) domain of PLA2R and the single-chain variable fragment (scFv) of an antibody against the T cell antigen CD3, connected by a small flexible linker.ResultsBiAATE creates an immunological synapse between autoreactive B cells bearing an CysR-specific surface Ig+ and T cells. Ex vivo, the BiAATE successfully induced T cell-dependent depletion of PLA2R-specific B cells isolated form MN patients, sparing normal B cells. Systemic administration of BiAATE to mice transgenic for human CD3 reduced anti-PLA2R antibody levels following active immunization with PLA2R.DiscussionShould this approach be confirmed for other autoimmune diseases, BiAATEs could represent a promising off-the-shelf therapy for precision medicine in virtually all antibody-mediated autoimmune diseases for which the pathogenic autoantigen is known, leading to a paradigm shift in the treatment of these diseases.
C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types
Authors: Broce Iris J. , Sirkis Daniel W. , Nillo Ryan M. , Bonham Luke W. , Lee Suzee E. , Miller Bruce L. , Castruita Patricia A. , Sturm Virginia E. , Sugrue Leo S. , Desikan Rahul S. , Yokoyama Jennifer S. 
Published: February 2024

IntroductionA hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 (C9orf72) is recognized as the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and ALS-FTD. Identifying genes that show similar regional co-expression patterns to C9orf72 may help identify novel gene targets and biological mechanisms that mediate selective vulnerability to ALS and FTD pathogenesis.MethodsWe leveraged mRNA expression data in healthy brain from the Allen Human Brain Atlas to evaluate C9orf72 co-expression patterns. To do this, we correlated average C9orf72 expression values in 51 regions across different anatomical divisions (cortex, subcortex, and cerebellum) with average gene expression values for 15,633 protein-coding genes, including 54 genes known to be associated with ALS, FTD, or ALS-FTD. We then performed imaging transcriptomic analyses to evaluate whether the identified C9orf72 co-expressed genes correlated with patterns of cortical thickness in symptomatic C9orf72 pathogenic HRE carriers (n = 19) compared to controls (n = 23). Lastly, we explored whether genes with significant C9orf72 imaging transcriptomic correlations (i.e., “C9orf72 imaging transcriptomic network”) were enriched in specific cell populations in the brain and enriched for specific biological and molecular pathways.ResultsA total of 2,120 genes showed an anatomical distribution of gene expression in the brain similar to C9orf72 and significantly correlated with patterns of cortical thickness in C9orf72 HRE carriers. This C9orf72 imaging transcriptomic network was differentially expressed in cell populations previously implicated in ALS and FTD, including layer 5b cells, cholinergic neurons in the spinal cord and brainstem and medium spiny neurons of the striatum, and was enriched for biological and molecular pathways associated with protein ubiquitination, autophagy, cellular response to DNA damage, endoplasmic reticulum to Golgi vesicle-mediated transport, among others.ConclusionConsidered together, we identified a network of C9orf72 associated genes that may influence selective regional and cell-type-specific vulnerabilities in ALS/FTD.
Efficacy of polyethylene glycol loxenatide for type 2 diabetes mellitus patients: a systematic review and meta-analysis
Authors: Liu Yibo , Ma Wenjing , Fu Hui , Zhang Zhe , Yin Yanyan , Wang Yongchun , Liu Wei , Yu Shaohong , Zhang Zhongwen 
Published: February 2024

Objective: Some studies have proved that polyethylene glycol loxenatide (PEG-Loxe) has significant effects on controlling blood glucose and body weight in patients with type 2 diabetes mellitus (T2DM), but there is still some controversy over the improvement of blood lipid profiles (BLP) and blood pressure (BP), and more evidences are needed to verify such effects. Therefore, this study was conducted to provide a comprehensive evaluation of the efficacy of PEG-Loxe in improving blood glucose (BG), BLP, BP, body mass index (BMI), and body weight (BW) in patients with T2DM for clinical reference.Methods: Randomized controlled trials (RCT) in which PEG-Loxe was applied to treat T2DM were retrieved by searching PubMed, Cochrane Library, Embase, Medline, Scopus, Web of Science, China National Knowledge Infrastructure, China Scientific Journal, Wanfang Data, and SinoMed databases. Outcome measures included BG, BLP, BP, BMI, and BW. RevMan 5.3 software was used to perform data analysis.Results: Eighteen trials were identified involving 2,166 patients. In experimental group 1,260 patients received PEG-Loxe alone or with other hypoglycemic agents, while in control group 906 patients received placebo or other hypoglycemic agents. In the overall analysis, PEG-Loxe significantly reduced the levels of glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2-h postprandial blood glucose (2-h PBG), BMI, and BW compared with control group. However, it had no obvious effect on total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP).Conclusion: PEG-Loxe has better hypoglycemic effects compared with placebo in patients with T2DM, but could not significantly improved TG, LDL-C, HDL-C, SBP, and DBP. And the combination of conventional hypoglycemic drugs (CHD) and PEG-Loxe could more effectively improve the levels of HbA1c, FPG, 2-h PBG, TC, TG, BMI, and BW compared with CHD in T2DM patients.Systematic Review Registration:www.inplasy.com, identifier INPLASY202350106