bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different biologics for biological-naïve patients with psoriatic arthritis: a systematic review and network meta-analysis
Authors: Lin Jixia , Ren Yougang 
Published: March 2024

Aim: To systematically compare the efficacy and safety of biologics [tumor necrosis factor inhibitors (TNFi), interleukin (IL) inhibitors, phosphodiesterase-4 inhibitors (PDE4i), and Janus kinase inhibitors (JAKi)] for biological-naïve patients with psoriatic arthritis (PsA).Methods: PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched until 12 March 2023. Only head-to-head active comparison studies were included, and placebo-controlled studies without active biologic comparators were excluded. Outcomes included musculoskeletal endpoint [American College of Rheumatology (ACR) 20/50/70, resolution of enthesitis, resolution of dactylitis], function endpoint [Health Assessment Questionnaire-Disability Index (HAQ-DI) change, ∆ HAQ-DI ≥ 0.35], composite index endpoint [ACR 50 + Psoriasis Area Severity Index (PASI) 100], and adverse events. The Jadad scale and Newcastle-Ottawa scale (NOS) were adopted to evaluate the quality of eligible studies.Results: Totally 17 studies with head-to-head comparisons of these biologics were included in this systematic review and network meta-analysis. Compared with IL-17A inhibitors (IL-17Ai), TNFi were associated with a lower rate of achieving ACR 20 response [pooled risk ratios (RR) = 0.92, 95% credibility interval (CrI): 0.86, 0.98]. JAKi had the greatest possibility of achieving ACR 20 (50.25%) and ACR 50 (83.03%). The JAKi group had a higher rate of achieving ACR 70 response than the IL-17Ai group (pooled RR = 1.25, 95%CrI: 1.00, 1.57); TNFi were less effective than JAKi in terms of ACR 70 (pooled RR = 0.77, 95%CrI: 0.64, 0.94). ACR 70 was most likely to be achieved in patients using JAKi (97.48%). The IL-17Ai group had a higher rate of enthesitis resolution than the TNFi group [pooled RR = 1.22, 95% confidence interval (CI): 1.02, 1.47]. Compared with IL-17Ai, TNFi were associated with a lower rate of enthesitis resolution (pooled RR = 0.80, 95%CrI: 0.72, 0.88). Patients receiving IL-17Ai had the highest likelihood of achieving enthesitis resolution (82.76%), dactylitis resolution (58.66%) and the greatest HAQ-DI change (59.74%). IL-17Ai had a similar impact in achieving ∆ HAQ-DI ≥ 0.35 to TNFi (pooled RR = 1.15, 95%CI: 0.93, 1.41). Individuals receiving IL-17Ai had a higher rate of achieving combined ACR 50 and PASI 100 response than those receiving TNFi (pooled RR = 1.56, 95%CI: 1.29, 1.88). Patients receiving PDE4i were least likely to have adverse events (41.59%).Conclusion: In 2023, considering both efficacy and safety, IL-17Ai may be the better treatment option for biological-naïve patients with PsA requiring biological therapy.
Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats
Authors: Reyne Nicole , Cmielewski Patricia , McCarron Alexandra , Smith Ronan , Schneider-Futschik Elena , Eikelis Nina , Pirakalathanan Piraveen , Parsons David , Donnelley Martin 
Published: March 2024

Introduction:Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies has led to significant health improvements in individuals with this mutation. While numerous animal models of CF exist, few have a CFTR mutation that is amenable to the triple combination therapy elexacaftor-tezacaftor-ivacaftor (ETI).Methods: To determine the responsiveness of Phe508del rats to ETI, a baseline nasal potential difference was measured. Subsequently, they received ETI daily for 14 days, after which post-treatment nasal potential difference, lung mechanics (via flexiVent) and lung ventilation (via X-ray Velocimetry) were assessed.Results: Chloride ion transport in nasal airways was restored in Phe508del rats treated with ETI, but neither lung mechanics nor ventilation were significantly altered.Discussion: These findings validate the usefulness of this rat model for future investigations of modulator therapy in CF.
Growing through adversity: the relation of early childhood educator post-traumatic growth to young children’s executive function
Authors: Clark Caron A. C. , Hatton-Bowers Holly , Akhavein Kimia , Rasby Sarah , Parra Gilbert R. 
Published: March 2024

IntroductionEarly childhood educators (ECEs) play a critical role in supporting the development of young children’s executive functions (EF). EF, in turn, underpins lifelong resilience and well-being. Unfortunately, many ECEs report adverse childhood experiences (ACEs) that may compound high stress levels associated with an emotionally and physically demanding profession. ACEs have well-established negative implications for adult well-being and may dampen ECEs’ capacities to engage in emotionally responsive interactions with children. However, many individuals who experience ACEs also report post-traumatic growth experiences that foster empathy, self-determination, and resilience. Such post-traumatic growth may equip teachers with skills to engage in responsive interactions with children that support children’s EF. The aim of this study was to explore the relations of ECE ACEs and post-traumatic growth to the EF of children in their classrooms.MethodsFifty-three female ECEs self-reported on their ACEs and post-traumatic growth. Parents of 157 children (53% male, 47% female, M age = 4.38 years) rated children’s EF.ResultsIn a set of linear mixed models that accounted for multiple demographic factors and ECE perceived workplace stressors, ECE ACEs were not significantly related to children’s EF scores. However, controlling for ACEs, higher levels of ECE post-traumatic growth were associated with fewer parent-reported EF difficulties in children.DiscussionECEs may draw on the coping skills they have developed in times of adversity to model and promote healthy EF for children. Mental health supports to facilitate ECEs’ processing of their own trauma may be a fruitful means to foster positive early childhood environments that nurture the well-being and resilience of future generations.
Evaluation of a multi-site health services psychology training program for telehealth and integrated behavioral health
Authors: McCord Carly , Garney Whitney , Garcia Kristen , Macareno Blanca , Williamson Meredith 
Published: March 2024

IntroductionTraining future providers in telehealth and integrated care models can improve access and outcomes, especially among rural and underserved populations. The (blinded) project implemented behavioral health training for health service psychology doctoral students with three partner organizations. Trainees received both experiential and didactic training in telehealth and integrated behavioral health. Telehealth was utilized for remote warm hand-offs, hybrid shared appointments, therapy sessions, coordination with providers, and supervision. Program elements included opportunities for consultations with experts in other disciplines, supportive mentorship, exposure to various parts of a healthcare system, and interactions with diverse clients.MethodsThe (blinded) training program evaluated trainee outcomes using fourteen interviews and three focus groups. Interviews and focus groups examined aspects of the program that contributed to trainees’ knowledge, skills, and attitudes.ResultsEvaluation results revealed increased levels of trainee confidence, autonomy and independence. Training reportedly enabled improved ability to collaborate and communicate with other professions, increased flexibility and adaptability, and openness to others’ ideas. Trainees reported the program’s use of telehealth enhanced awareness of their own skills and team members’ perspectives of technology in care delivery.DiscussionDescriptions of the three care models, lessons learned, and qualitative results about trainee outcomes can be translated into best practices for workforce development and enhance psychology trainees’ self-awareness and ability to incorporate others’ viewpoints about technology and treatment approaches into healthcare.
Examining a sentiment algorithm on session patient records in an eating disorder treatment setting: a preliminary study
Authors: Huisman Sophie M. , Kraiss Jannis T. , de Vos Jan Alexander 
Published: March 2024

BackgroundClinicians collect session therapy notes within patient session records. Session records contain valuable information about patients’ treatment progress. Sentiment analysis is a tool to extract emotional tones and states from text input and could be used to evaluate patients’ sentiment during treatment over time. This preliminary study aims to investigate the validity of automated sentiment analysis on session patient records within an eating disorder (ED) treatment context against the performance of human raters.MethodsA total of 460 patient session records from eight participants diagnosed with an ED were evaluated on their overall sentiment by an automated sentiment analysis and two human raters separately. The inter-rater agreement (IRR) between the automated analysis and human raters and IRR among the human raters was analyzed by calculating the intra-class correlation (ICC) under a continuous interpretation and weighted Cohen’s kappa under a categorical interpretation. Furthermore, differences regarding positive and negative matches between the human raters and the automated analysis were examined in closer detail.ResultsThe ICC showed a moderate automated-human agreement (ICC = 0.55), and the weighted Cohen’s kappa showed a fair automated-human (k = 0.29) and substantial human-human agreement (k = 0.68) for the evaluation of overall sentiment. Furthermore, the automated analysis lacked words specific to an ED context.Discussion/conclusionThe automated sentiment analysis performed worse in discerning sentiment from session patient records compared to human raters and cannot be used within practice in its current state if the benchmark is considered adequate enough. Nevertheless, the automated sentiment analysis does show potential in extracting sentiment from session records. The automated analysis should be further developed by including context-specific ED words, and a more solid benchmark, such as patients’ own mood, should be established to compare the performance of the automated analysis to.
Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis
Authors: Tao Lin , Xiang Yuping , Zeng Xiaohong , Fu Lan , Li Junying , Chen Hong 
Published: March 2024

IntroductionCancer-related distress can be described as a complex and unpleasant combination of psychological (such as cognitive, behavioral, and emotional), social, and spiritual challenges that may impact an individual’s ability to effectively cope with the physical symptoms of cancer and its treatment. Existing literature has confirmed psychological distress (PD) as an important sequela of breast cancer diagnosis and treatment. However, the incidence and risk factors for PD in adult female patients with breast cancer remain unclear; therefore, focusing on the PD of female breast cancer patients is meaningful, as they are at highest risk of contracting breast cancer, and might differ in their coping styles from men.ObjectiveThis review aimed to identify the incidence and risk factors for PD in adult woman patients with breast cancer, and to help guide targeted intervention to prevent distress.MethodPubMed, Embase, Cochrane Library, CINAL, PsycINFO, China Knowledge Resource Integrated Database, Wanfang Database, the Chinese Biomedical Database, and Weipu Database were searched for data regarding the incidence and risk factors of PD in adult women with breast cancer.ResultsThe prevalence of PD, assessed using the distress thermometer, ranged between 11.2%–86.7%, and a meta-analysis of 47 studies with 15,157 adult female breast cancer patients showed that the pooled prevalence was 52.0%. Further, this study identified 40 risk factors. However, owing to the inclusion of at least two studies for a certain risk factor, 10 risk factors were merged for the meta-analysis. Independent risk factors included higher education level, late-stage tumor, emotional concerns, no medical insurance, modified radical mastectomy, and history of depression; age and neuroticism were not associated with PD; and higher monthly income was revealed as a protective factor against it.ConclusionThe incidence of PD in female patients with breast cancer is high and it involves 10 risk factors, though some are controversial owing to insufficient evidence. Further research is needed to explore the underlying mechanisms of PD and develop risk factor-based holistic intervention programs to reduce its incidence.Systematic review registrationThe protocol of this study has been registered in the database PROSPERO (registration ID: CRD42023433578).
Exploring a career pathway for home support workers in Ireland: a systematic scoping review of the international evidence
Authors: Morrow Elizabeth , Kelly Carmel , Killeen Clodagh , Naessens Edward , Lynch Mary 
Published: March 2024

BackgroundIn prosperous nations like Ireland, home support workers (HSWs) play an increasingly vital role in providing person-centred care to ageing populations. However, challenges such as workforce shortages, role ambiguity, low pay, and limited career advancement, hinder workforce development and career building.MethodA scoping review using key terms for “HSWs” and “career pathways” was conducted following the Joanna Briggs Institute Methodology, examining electronic databases (Web of Science, PubMed, MEDLINE, EMBASE, CINAHL, PscyINFO, Social Care Online, Social Sciences Citation Index). Inclusion criteria were applied, and a thematic analysis followed and inductive-deductive approach.ResultsThe review encompassed 261 relevant articles from different countries. Four key themes were identified: (1) Data-driven decision-making on the future workforce, (2) Attracting and developing a competent and motivated home support workforce, (3) Enhancing working lives and retention at every stage of career pathways, and (4) Crafting career pathways to improve quality and impact.DiscussionLeadership, collaboration, and data-driven decision-making across policy, research and practice are pivotal for expanding and enhancing home support. Emphasising a shift towards preventative self-management models, supported by digitally skilled and regulated HSWs, could enhance independence and quality of care. Clear career structures, professional development, and inclusive organisational environments are essential to attract, retain, and empower a competent and motivated workforce, fostering quality and impact.ConclusionThis scoping review provides foundational evidence to establish career pathways for HSWs, identifying key areas for development such as data collection, care model transformation, career progression structures, and systems for safety and quality improvement.
Enhancing walking efficiency of adolescents with neurological impairments using an exosuit for ambulatory activities of daily living
Authors: Basla Chiara , Mariani Giulia , Wolf Peter , Riener Robert , van Hedel Hubertus J. A. 
Published: March 2024

Introduction: Children and adolescents with neurological impairments face reduced participation and independence in daily life activities due to walking difficulties. Existing assistive devices often offer insufficient support, potentially leading to wheelchair dependence and limiting physical activity and daily life engagement. Mobile wearable robots, such as exoskeletons and exosuits, have shown promise in supporting adults during activities of daily living but are underexplored for children.Methods: We conducted a cross-sectional study to examine the potential of a cable-driven exosuit, the Myosuit, to enhance walking efficiency in adolescents with diverse ambulatory impairments. Each participant walked a course including up-hill, down-hill, level ground walking, and stairs ascending and descending, with and without the exosuit’s assistance. We monitored the time and step count to complete the course and the average heart rate and muscle activity. Additionally, we assessed the adolescents’ perspective on the exosuit’s utility using a visual analog scale.Results: Six adolescents completed the study. Although not statistically significant, five participants completed the course with the exosuit’s assistance in reduced time (time reduction range: [-3.87, 17.42]%, p-value: 0.08, effect size: 0.88). The number of steps taken decreased significantly with the Myosuit’s assistance (steps reduction range: [1.07, 15.71]%, p-value: 0.04, effect size: 0.90). Heart rate and muscle activity did not differ between Myosuit-assisted and unassisted conditions (p-value: 0.96 and 0.35, effect size: 0.02 and 0.42, respectively). Participants generally perceived reduced effort and increased safety with the Myosuit’s assistance, especially during tasks involving concentric contractions (e.g., walking uphill). Three participants expressed a willingness to use the Myosuit in daily life, while the others found it heavy or too conspicuous.Discussion: Increased walking speed without increasing physical effort when performing activities of daily living could lead to higher levels of participation and increased functional independence. Despite perceiving the benefits introduced by the exosuit’s assistance, adolescents reported the need for further modification of the device design before using it extensively at home and in the community.
Stigmatized Stroke? A Qualitative Study of Perception of Stroke Among Community Residents With Hypertension
Authors: Wan Meijuan , Liu Xiaoxu , Zhang Mengdi , Cui Zixin , Zhao Wenjuan , Li Jianzhou , Lin Shumei 
Published: March 2024

Objectives: To understand the perception of stroke in the hypertensive population. Hypertension is the primary risk factor for stroke, and current approaches to stroke prevention are inadequate and often fragmented. Understanding the perception of stroke among individuals with hypertension is crucial for a targeted approach. However, empirical evidence on this perception is limited.Methods: A qualitative design involved thematic analysis of focus groups and interview data from urban China with hypertension. Audio recordings were transcribed and subjected to thematic analysis.Results: Three themes were identified. Hypertensive participants first identified stroke patients by their obvious physical disability, and then identified the disease as a negative thing. Finally, they wanted to stay away from stroke, but paradoxically, there is a contradictory approach to avoidance and prevention, such as being willing to prevent the disease or simply avoiding socializing with stroke patients.Conclusion: Hypertensive patients hold complex and diverse perceptions of stroke, including a certain stigma. Future public health education should prioritize improving media promotion and fostering interaction between patients with hypertension and stroke in the community.
ASUHAN KOMPREHENSIF PADA NY. D DENGAN KPD DAN HIPERTENSI GESTASIONAL DISERTAI PENERAPAN PIJAT ENDORPHIN DAN AROMATHERAPHY
Authors: Khoerotun Nisa Rifka , Pulungan Yulinda 
Published: March 2024

Asuhan kebidanan komprehensif adalah asuhan yang diberikan secara menyeluruh dan berkesinambungan, diantaranya yaitu pada saat bersalin. Hal ini dilakukan untuk mendeteksi adanya komplikasi dalam persalinan seperti Ketuban Pecah Dini dan Hipertensi Gestasional. Dalam proses persalinan terjadi sebuah kombinasi antara proses fisik dan pengalaman emosional bagi seorang perempuan. Salah satu upaya dalam mengatasi kecemasan dan meningkatkan kemajuan persalinan adalah dengan memberikan asuhan pijat endorpin dan aromaterapi. Pijat endorpin adalah teknik sentuhan ringan yang dapat membantu memberikan rasa tenang dan nyaman dalam proses persalinan serta meningkatkan hormon oksitosin yang jarang diketahui oleh banyak orang. Selain itu, pemberian aromaterapi sereh dan minyak zaitun dengan metode uap air serta inhalasi mampu memberikan kenyaman ataupun ketenangan pada saat menghadapi persalinan. Sehingga persalinan dapat berjalan dengan lebih nyaman, tenang dan fokus dengan kontraksi yang lebih stabil. Laporan pada studi kasus ini menggunakan metode studi penelaahan kasus (case study) yang terdiri dari unit tunggal. Unit tunggal merupakan satu orang ibu yang diberikan asuhan sejak masa kehamilan hingga KB dengan penerapan asuhan kebidanan 7 Langkah Varney pada pengkajian awal disertai menggunakan metode SOAP ( Subjektif, objektif, analisis, penatalaksanaan) dan dilakukan sejak 2 Februari 2023 hingga 7 April 2023. Didapatkan hasil bahwa aromaterapi sereh kombinasi minyak zaitun dan pemberian pijat endorphin mempengaruhi/1penurunan kecemasan pada saat bersalin. Selain itu, dengan adanya kenyaman pada ibu mampu meningkatkan konsentrasi pada ibu dan peningkatan kontraksi dengan lebih stabil pada janin. Sehingga Persalinan dapat berjalan dengan baik.
Kata Kunci : Pijat Endorpin, Aromaterapi, KPD, Hipertensi
ANALISIS PENGARUH KEPEMILIKAN INSTITUSIONAL, KOMISARIS INDEPENDEN, LEVERAGE, UKURAN PERUSAHAAN DAN PROFITABITAS TERHADAP TAX AVOIDANCE (Studi Empiris pada Industri Barang Konsumsi yang Terdaftar di Bursa Efek Indonesia tahun 2014-2018)
Authors: Widaryanti Widaryanti 
Published: March 2024

This study aims to obtain empirical evidence on the effect of institutional ownership, independent commissioners, leverage, firm size and profitability on tax avoidance. This esearch is focused on the Consumer Goods Industry Listed on the Indonesia Stock Exchange in 2014-2018. The observations in this study were as many as 85 samples. Research obtained by on probability sampling method, namely purposive sampling technique. The technique used in his research is multiple linear regression analysis. The results of this analysis indicate that everage and firm size have an effect on tax avoidance, but institusional ownership, independent ommissioners and profitability have no effect on tax avoidance.Keywords: Institutional Ownership, Independent Commissioner, Leverage, Firm Size, Profitability, Tax Avoidance.