bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pool Fires Within a Large Under-Ventilated Environment: Experimental Analysis and Numerical Simulation Using OpenFOAM
Authors: Cavazzuti Marco , Tartarini Paolo 
Published: March 2024

AbstractExperimental analyses and numerical simulations are carried out on a test case involving an heptane pool fire within a large under-ventilated environment. During the experiments, the temperature history at several locations within the room is monitored by means of thermocouples, and the fire radiative heat transfer estimated through a plate thermocouple. The experimental layout is then replicated numerically and tested using OpenFOAM CFD code. The study is a preliminary analysis performed for code validation purposes on a full-scale fire scenario. The results of the simulations are compared to the experimental results and critically analysed, finding a reasonable agreement overall. Critical issues in fire modelling are also highlighted. In fact, due to the problem complexity and the limitations of the numerical models available some important aspect that can significantly influence the outcome of the simulations must be calibrated a posteriori, somewhat limiting the general predictive applicability of the fire models. Primarily, these are the heat release rate history, the combustion efficiency, and, to a lesser extent, the convective heat transfer boundary condition at the wall.
Pancreatic adenocarcinoma treated with surgical resection, toceranib phosphate and firocoxib in a dog: a case report
Authors: Fuertes-Recuero Manuel , Vázquez-Fernández Esther , Lizasoain-Sánz Guillermo , Arroba-Alonso Amanda , Sánchez-López Alejandro , Martínez-de-Merlo Elena , Suárez-Redondo María , Ortiz-Diez Gustavo 
Published: March 2024

AbstractExocrine pancreatic carcinomas are rarely reported in dogs. A ductal pancreatic adenocarcinoma in a 10-year-old intact beagle is described in this report. The diagnosis was made based on clinical signs, imaging (abdominal ultrasound and CT scan) and histopathology. Treatment consisted of partial right lobe pancreatectomy followed by adjuvant therapy with toceranib phosphate (Palladia®) and firocoxib (Previcox®) for six months. The treatment was well tolerated, and the survival time was 445 days. To our knowledge, this is the longest survival reported in the literature for a dog diagnosed with exocrine pancreatic adenocarcinoma. The results described here may contribute to provide a better understanding about this neoplasia and potential treatment options.
Contextually aware intelligent control agents for heterogeneous swarms
Authors: Hepworth Adam J. , Hussein Aya S. M. , Reid Darryn J. , Abbass Hussein A. 
Published: March 2024

AbstractAn emerging challenge in swarm shepherding research is to design effective and efficient artificial intelligence algorithms that maintain simplicity in their decision models, whilst increasing the swarm’s abilities to operate in diverse contexts. We propose a methodology to design a context-aware swarm control intelligent agent (shepherd). We first use swarm metrics to recognise the type of swarm that the shepherd interacts with, then select a suitable parameterisation from its behavioural library for that particular swarm type. The design principle of our methodology is to increase the situation awareness (i.e. contents) of the control agent without sacrificing the low computational cost necessary for efficient swarm control. We demonstrate successful shepherding in both homogeneous and heterogeneous swarms.
Use of Online Communities among People with Type 2 Diabetes: A Scoping Review
Authors: Bujanda-Sainz de Murieta Arantxa , Soto-Ruiz Nelia , García-Vivar Cristina , San Martín-Rodríguez Leticia , Escalada-Hernández Paula 
Published: March 2024

Abstract
Purpose of Review
People with diabetes require continuous self-monitoring and face numerous decisions in their day-to-day lives. Therefore, on many occasions, they need more support than that provided by health professionals. In this context, peer support in online diabetes communities could be a useful tool. The purpose of the review is to describe, analyze and synthesize the available evidence on the use and health out-comes of online communities for people with type 2 diabetes mellitus. A scoping review was conducted in accordance with the Joanna Briggs Institute guidelines. Searches were performed PubMed, Web of Science, CINHAL, Scopus and Cochrane databases.

Recent Findings
From 1821 identified documents, 6 articles were included. These studies explored the characteristics of diabetes online communities and the population features. Besides, the results were classified according to whether they were clinical, psychosocial, or addressed people's experiences with the online community. The analysis underscores their value in facilitating communication, improving diabetes management, and enhancing psychosocial well-being. Future investigations should prioritize longitudinal assessments to elucidate the sustained impact of community engagement and optimize user participation for enhanced patient outcomes.

Summary
The growing relevance of new technologies has led to a significant number of individuals with chronic illnesses seeking peer support. Online health communities have emerged as virtual spaces where individuals with shared health interests interact and form relationships. Within these digital spaces, individuals can engage in peer interaction, observe behaviors, and mutually benefit, potentially leading to improved attitudes toward the disease.
AIH Therapy: Beyond First-Line
Authors: Adao Irina , Klepper Arielle , Tana Michele 
Published: March 2024

Abstract
Purpose of Review
The purpose of the article is to review treatment options for patients with AIH for whom first-line therapy is not successful. We outline recommended approaches for providers and new therapies on the horizon.

Recent Findings
Budesonide, while advantageous in some respects, may not be as effective as predniso(lo)ne. Mycophenolate mofetil is most effective in the setting of azathioprine intolerance and less effective when the response to azathioprine has been inadequate. Infliximab is the biologic agent with the most evidence for use in AIH. Clinical trials studying interleukin 2, regulatory T cells, inhibitors of BAFF signaling, and immunoproteasome inhibitors have been initiated but more research is needed, particularly in Black people, Indigenous people, and People of Color.

Summary
While multiple agents have been reported as second- or third-line therapies, the evidence is limited. Future research will require multicenter collaboration and should explore therapeutics supported by molecular studies.
Peripheral artery disease: an underdiagnosed condition in familial hypercholesterolemia? A systematic review
Authors: Acitelli Elisa , Guedon Alexis F. , De Liguori Sara , Gallo Antonio , Maranghi Marianna 
Published: March 2024

Abstract
Purpose
Familial hypercholesterolemia (FH) is one of the most common inherited diseases characterized by elevated LDL-cholesterol levels, leading to early-onset atherosclerosis. While the association between FH and coronary and carotid artery disease is well-established, its association with peripheral artery disease (PAD) is less robust. This systematic review aims at exploring existing evidence on PAD prevalence and incidence in FH individuals.

Methods
A comprehensive search was conducted on MEDLINE and Embase databases, for studies published between January 2013 and December 2023, evaluating prevalence and incidence of PAD in FH patients. Literature reviews, case reports, responses to editors and non-English language articles were excluded.

Results
The initial research provided 53 results. After article screening, 28 articles were fully reviewed and 24 were finally included in the analysis. Among these, 19 reported PAD prevalence, while 5 PAD incidence over a mean follow-up time of 8.7 years. PAD prevalence and incidence ranged from 0.3 to 60% and from 0.5 to 4.2% respectively, probably reflecting the heterogeneity in PAD definition criteria.

Conclusion
This systematic review sheds light on the limited number of studies on PAD in FH patients. Particularly, considering the potential positive effects of newly available lipid-lowering strategies on PAD outcomes, addressing this research gap is pivotal for a more comprehensive understanding of peripheral vascular manifestations in FH patients and for optimal management of this population.
m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD
Authors: Ren Xin , Feng Zhuxiao , Ma Xiaodong , Huo Lijuan , Zhou Huiying , Bai Ayu , Feng Shujie , Zhou Ying , Weng Xuchu , Fan Changhe 
Published: March 2024

AbstractMajor depressive disorder (MDD) is a prevalent psychiatric condition often accompanied by severe impairments in cognitive and functional capacities. This research was conducted to identify RNA modification-related gene signatures and associated functional pathways in MDD. Differentially expressed RNA modification-related genes in MDD were first identified. And a random forest model was developed and distinct RNA modification patterns were discerned based on signature genes. Then, comprehensive analyses of RNA modification-associated genes in MDD were performed, including functional analyses and immune cell infiltration. The study identified 29 differentially expressed RNA modification-related genes in MDD and two distinct RNA modification patterns. TRMT112, MBD3, NUDT21, and IGF2BP1 of the risk signature were detected. Functional analyses confirmed the involvement of RNA modification in pathways like phosphatidylinositol 3-kinase signaling and nucleotide oligomerization domain (NOD)-like receptor signaling in MDD. NUDT21 displayed a strong positive correlation with type 2 T helper cells, while IGF2BP1 negatively correlated with activated CD8 T cells, central memory CD4 T cells, and natural killer T cells. In summary, further research into the roles of NUDT21 and IGF2BP1 would be valuable for understanding MDD prognosis. The identified RNA modification-related gene signatures and pathways provide insights into MDD molecular etiology and potential diagnostic biomarkers.
Contribution Analysis of Large Language Models and Data Augmentations for Person Names in Solving Legal Bar Examination at COLIEE 2023
Authors: Onaga Takaaki , Fujita Masaki , Kano Yoshinobu 
Published: March 2024

AbstractThis paper describes our system for COLIEE 2023 Task 4, which automatically answers Japanese legal bar exam problems. We propose an extension to our previous system in COLIEE 2022, which achieved the highest accuracy among all submissions using data augmentation. We focus on problems that include mentions of person names. In this paper, we present two main contributions. First, we incorporate LUKE as our deep learning component, which is a named entity recognition model trained on RoBERTa. Second, we fine-tune the pretrained LUKE model in multiple ways, comparing fine-tuning on training datasets that include alphabetical person names and ensembling different fine-tuning models. We confirmed that LUKE and its fine-tuned model on person type problems improve their accuracies. Our formal run results show that LUKE and our fine-tuning approach using alphabetical person names were effective, achieving an accuracy of 0.69 in the COLIEE 2023 Task 4 formal run.
Nano/Micro-Structural Supramolecular Biopolymers: Innovative Networks with the Boundless Potential in Sustainable Agriculture
Authors: Saberi Riseh Roohallah , Hassanisaadi Mohadeseh , Vatankhah Masoumeh , Varma Rajender S. , Thakur Vijay Kumar 
Published: March 2024

AbstractSustainable agriculture plays a crucial role in meeting the growing global demand for food while minimizing adverse environmental impacts from the overuse of synthetic pesticides and conventional fertilizers. In this context, renewable biopolymers being more sustainable offer a viable solution to improve agricultural sustainability and production. Nano/micro-structural supramolecular biopolymers are among these innovative biopolymers that are much sought after for their unique features. These biomaterials have complex hierarchical structures, great stability, adjustable mechanical strength, stimuli-responsiveness, and self-healing attributes. Functional molecules may be added to their flexible structure, for enabling novel agricultural uses. This overview scrutinizes how nano/micro-structural supramolecular biopolymers may radically alter farming practices and solve lingering problems in agricultural sector namely improve agricultural production, soil health, and resource efficiency. Controlled bioactive ingredient released from biopolymers allows the tailored administration of agrochemicals, bioactive agents, and biostimulators as they enhance nutrient absorption, moisture retention, and root growth. Nano/micro-structural supramolecular biopolymers may protect crops by appending antimicrobials and biosensing entities while their eco-friendliness supports sustainable agriculture. Despite their potential, further studies are warranted to understand and optimize their usage in agricultural domain. This effort seeks to bridge the knowledge gap by investigating their applications, challenges, and future prospects in the agricultural sector. Through experimental investigations and theoretical modeling, this overview aims to provide valuable insights into the practical implementation and optimization of supramolecular biopolymers in sustainable agriculture, ultimately contributing to the development of innovative and eco-friendly solutions to enhance agricultural productivity while minimizing environmental impact.
MRI quantitative hemodynamic parameter histogram assement of hepatocellular carcinoma development in a rabbit VX2 liver cancer model
Authors: Guo Rui , Song Zhiqiang , Zuo Pengpeng , An Jiajia , Deng Defeng , Li Jinfang , Wu Ying , Ma Jing 
Published: March 2024

Abstract
Background
Nowadays, liver cancer is the second leading cause of cancer death in the world. Therefore, it is very important to understand tumor progression and evaluate tumor microcirculation for treatment strategy.

Objective
To explore the application of MRI quantitative hemodynamic parameter histogram analysis in the development of a rabbit VX2 liver cancer.

Methods
Five New Zealand white rabbits were randomly selected each time for liver Dynamic contrast- enhanced MR perfusion (DCE-MRI) imaging at the 1st, 2nd, 3rd, 4th and 5th weeks after liver tumor implantation. The dynamic changes and the significant differences between the tumor volume and related derived parameters during tumor progression were compared and analyzed.

Results
In the development of the VX2 liver cancer model, the tumor volume between the end of 1 ~ 5w group (F = 44.11; P = 0.000) was statistically significant (P < 0.01), and the significant differences were found between the 5th week and the 1st, 2nd, 3rd, 4th week, the 4th week and the 1st, 2nd week, the 3rd week and the 5th week (P < 0.01), respectively. The skewness and kurtosis of the volume transport constant (Ktrans) value, the maximum, 90th percentile and skewness of the reverse reflux rate constant (Kep) value, and the skewness, kurtosis, 75th and 90th percentiles of the plasma fraction (Vp) value were statistically significant (P < 0.05) at the end of each week. The 10th, 25th, 50th percentiles of the Kep value, the 10th, 25th percentiles of the extracellular space (EES) fraction (Ve) value, the 10th percentile of the Vp value was positively correlated with tumor volume (r > 0, P < 0.05). The expression of α-smooth muscle actin (α-SMA) was negatively correlated with the mean, 75th percentile of the Ktrans value, the 50th, 75th percentiles of the Kep value, the mean, minimum of the Vp value (r < 0, P<0.05). It was positively correlated with the skewness, kurtosis of the Ktrans value, the skewness of the Vp value (r > 0, P<0.05).

Conclusions
MRI quantitative hemodynamic parameter histogram analysis can reflect the progress of the rabbit VX2 liver cancer. In particular, the skewness, kurtosis and percentiles of Ktrans, Kep and Vp can reflect the microvascular information and can be used as biomarkers to assess the development of Hepatocellular Carcinoma(HCC).
CACA guidelines for holistic integrative management of lung cancer
Authors: Wang Jun ,   Society of Lung Cancer of China Anti-Cancer Association
Published: March 2024

AbstractLung cancer (LC) is among the malignant tumors with the highest disease burden in the world, accounting for approximately 11.4% of all cancer cases, and LC was the 2nd most common type of malignant tumor. The editing of the CACA Guidelines for Holistic Integrative Management of Lung Cancer aimed to facilitate the enhancement of lung cancer diagnosis and comprehensive treatment in China.The CACA Guidelines for Holistic Integrative Management of Lung Cancer include the epidemiology, the early detection, the comprehensive diagnosis, the treatment (including surgical, medical and radiological treatment), rehabilitation, and some general principles for both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).The main objective of this guideline is to standardize the clinical diagnosis and treatment process of lung cancer, with a specific focus on enhancing the management of this disease in China.
Invariant measures for -free systems revisited
Authors: DYMEK AURELIA , KUŁAGA-PRZYMUS JOANNA , SELL DANIEL 
Published: March 2024

AbstractFor
$\mathscr {B} \subseteq \mathbb {N} $
, the
$ \mathscr {B} $
-free subshift
$ X_{\eta } $
is the orbit closure of the characteristic function of the set of
$ \mathscr {B} $
-free integers. We show that many results about invariant measures and entropy, previously only known for the hereditary closure of
$ X_{\eta } $
, have their analogues for
$ X_{\eta } $
as well. In particular, we settle in the affirmative a conjecture of Keller about a description of such measures [G. Keller. Generalized heredity in
$\mathcal B$
-free systems. Stoch. Dyn.21(3) (2021), Paper No. 2140008]. A central assumption in our work is that
$\eta ^{*} $
(the Toeplitz sequence that generates the unique minimal component of
$ X_{\eta } $
) is regular. From this, we obtain natural periodic approximations that we frequently use in our proofs to bound the elements in
$ X_{\eta } $
from above and below.
The Role of Judicial Associations in Preventing Rule of Law Decay in Romania: Informal Communication and Strategic Use of Preliminary References
Authors: Doroga Sorina , Bercea Raluca 
Published: March 2024

AbstractThis Article explores the manner in which, faced with the rule of law crisis generated by the 2017–2019 national legislative reforms, the Romanian judicial associations, organized as NGOs, have fulfilled their declared purpose of safeguarding judicial independence. By relying on effective communication tactics—including international networking and lobbying or informal discussions with high-level EU representatives—coupled with a strategic use of preliminary references, they have shed light on some of the most sensitive elements of the Romanian context, garnering both internal and international support in the process. In particular, by taking advantage of the CJEU’s increased willingness to engage with questions concerning the rule of law and the organization of the national judicial systems, the Romanian judicial associations have managed to design strategies capable of triggering preliminary rulings on the most heated and politically charged questions concerning the judiciary. This Article seeks to highlight the specific features and informal elements of such strategies.
Schrödinger’s Judiciary—Formality at the Service of Informality in Hungary
Authors: Vincze Attila 
Published: March 2024

AbstractThere are two contrasting claims regarding the Hungarian judiciary. The Government asserts that it is in the best shape, while many other voices label it as captured or dependent. This article shows how both of these claims can be true, depending on the interplay between formality and informality and shows how a few small loopholes allow some actors to rig the judicial system. Therefore, the Hungarian judiciary is similar to Schrödinger’s cat, which is claimed to be dead and alive at the same time.The synergy between formality and informality requires a network of a handful of trusted people in managerial positions to administer case allocation, promotion, and disciplinary systems, which seem to be very effective tools. Few small technical loopholes and some special remedies suffice to micromanage important cases precisely because key positions are captured which work as gatekeepers or emergency brakes. Most of these tools are legal in a very formal technical sense of the word because they rely on acts of Parliament. A formal legalism, a very thin understanding of the Rule of law, and a majoritarian mindset serve as a legitimizing ideology for the whole legal system.
Mapping the evidence on psychosocial interventions for migrant populations: Descriptive analysis of a living database of randomized studies
Authors: Cadorin Camilla , Purgato Marianna , Turrini Giulia , Prina Eleonora , Cabral Ferreira Madalena , Cristofalo Doriana , Bartucz Monica B. , Witteveen Anke B. , Sijbrandij Marit , Papola Davide , Barbui Corrado 
Published: March 2024

Abstract
Migrant mental health is a pressing public health issue with wide-ranging implications. Many randomized controlled trials (RCTs) have been conducted in this population to assess the effects of psychosocial interventions. However, the available evidence is characterized by controversy and fragmentation, with studies focusing on different migrant populations, interventions, outcomes, delivery modalities and settings. Aiming to promote systematic reviews of the effectiveness of psychosocial interventions in different migrant groups, we have developed a living database of existing RCTs. The development of the database provides an opportunity to map the existing RCT evidence in this population. A total of 135 studies involving 24,859 participants were included in the living database. The distribution of studies by year of publication aligns with the increasing global migrant population in recent years. Most studies focus primarily on adult participants, with a limited representation of children and adolescents, and a prevalence of female participants, which is consistent with epidemiological data, except for older adults, who are underrepresented in research. Studies predominantly focus on refugees and asylum seekers, likely due to their elevated risk of mental health issues, despite the substantial presence of economic migrants worldwide. While studies mainly involve migrants from the Middle East and East Asia, epidemiological data suggest a broader geographic representation, with migrants coming from Eastern Europe, Latin America and South Asia. The present descriptive analysis of RCTs on mental health and psychosocial interventions for migrant populations provides valuable insights into the existing research landscape. It should be used to inform future research efforts, ensuring that studies are more representative of the global migrant population and more responsive to the mental health needs of migrants in different contexts.
Vulnerability, Recognition, and the Ethics of Pregnancy: A Theological Response
Authors: Kamitsuka Margaret D. 
Published: March 2024

AbstractVulnerability is a notion discussed in feminist philosophy as a basis for a morality that widens our sense of those whose deaths are grievable. Vulnerability and grievability also factor in reproductive ethics. This essay employs recognition theory to analyze critically how these notions are mobilized in conservative Christian anti-abortion writings and in feminist philosophy. This analysis exposes weaknesses and misrecognition in both sets of discourses. In response, I offer theological arguments for recognizing fetal value without implying a right to life and for acknowledging how human finitude and the precarity of pregnancy render gestational hospitality a discretionary, not obligatory, moral act.