bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and validation of a predictive model for prolonged length of stay after PCI for patients with acute myocardial infarction.
Authors: He Pei , Tian Hongwei , Fan Juan , Hu Yueling , Li Fangfang , Yang Mingjuan , Shi Juan 
Published: March 2024

Abstract

Objective To construct and validate of a predictive model for prolonged length of stay after PCI for patients with acute myocardial infarction.
Methods A retrospective analysis was conducted on the clinical data of 592 patients with acute myocardial infarction who underwent PCI treatment. They were divided into a modeling group (414 cases) and a validation group (178 cases) in a ratio of 7:3.Define prolonged length of stay as hospitalization for more than 7 days after surgery.Single-factor and multi-factor logistic regression analysis were used to construct a predictive model and it was validated.
Results Female gender (OR = 5.72, 95%CI: 2.10-15.58), smoking(OR = 4.41, 95%CI:1.76–11.02), hypertension(OR = 2.32, 95%CI:1.27–4.24), hs-cTnT(OR = 1.12, 95%CI:1.02–1.26)and Killip functional classification were identified as independent factors associated with prolonged length of hospital stay after PCI in patients with acute myocardial infarction (P < 0.05).A column line graph predictive model was built using the aforementioned independent factors. The area under the curve (AUC) for predicting prolonged length of hospital stay after surgery was 0.852 for the modeling group and 0.831 for the validation group.The calibration curve of the predictive model showed good consistency in both groups.
Conclusion This model can effectively predict the risk of prolonged length of hospital stay after PCI in patients with acute myocardial infarction, providing a basis for clinical management and nursing guidance.
Reference Values for Incremental Shuttle Walk Test in healthy Indian Children and Adolescents
Authors: Agarwal Bela , Shah Monal , Mullerpatan Rajani 
Published: March 2024

Abstract
Purpose: Early identification of physical inactivity in children and adolescents using a simple reliable test like Incremental shuttle walk test (ISWT) can aid in prescription of evidence based early interventional programs to enhance cardiopulmonary exercise capacity.
Methods: Thousand participants recruited for study were stratified into 3 biological age groups-Group A: 5-8 years, Group B: 9-12 years and Group C: 13-17 years. Anthropometric measures were recorded and ISWT was performed as per standard protocol across a 10-meter shuttle walkway.
Results: Incremental shuttle walk distance was greater in males compared to females in all age groups(ISWD Group 1 females 395.36m, ISWD Group 2 females 492.16m,ISWD Group 3 females 582.22m (p= 0.00), ISWD Group 1 males 414.22m, ISWD Group 2 males 536.71m and ISWD Group 3 males 698.62m(p=0.00) ISWD demonstrated significant positive correlation with age (r=0.491, p=0.00) and weak negative correlation with gender (r-0.123,p=0.00).Stepwise linear regression analysis was performed to generate a predicative equation for ISWD with age and gender model ISWD (r2 = 0.611).
ISWD = 168.23 + (232.93*Height) - (86.47*Gender) + (11.42*Age) (Males 1, Females 0)
Conclusion: Reference values generated for ISWD can be used for prescription and regular monitoring of cardio pulmonary endurance of children and adolescents.
Can we Reduce Short Hospitalizations in Medical Wards?
Authors: Nir Yael Frenkel , Levy Yuval , Grossman Ehud , Klang Eyal 
Published: March 2024

Abstract

Background
Sheba Medical Center (SMC) is the largest hospital in Israel and has been coping with a steady increase in total Emergency Department (ED) visits. Over 140,000 patients arrive at the SMC's ED every year. Of those, 19% are admitted to the medical wards. Some are very short hospitalizations (one night or less). This puts a heavy burden on the medical wards. We aimed to identify the characteristics of short hospitalizations.
Methods
We retrospectively retrieved data of consecutive adult patients admitted to our hospital during January 1, 2013, to December 31, 2019. We limited the cohort to patients who were admitted to the medical wards. We divided the study group into those with short and those with non-short hospitalization.
Results
Out of 133,126 patients' admissions, 59,994 (45.0%) were hospitalized for short term. Patients in the short hospitalization group were younger and had fewer comorbidities. The highest rate of short hospitalization was recorded during night shifts (58.4%) and the rate of short hospitalization was associated with the ED daily patient load (r = 0.36, p < 0.001). The likelihood of having a short hospitalization was most prominent in patients with suicide attempt (80.0% of those admitted for this complaint had a short hospitalization), followed by hypertension (68.6%). However, these complaints accounted for only 0.7% of the total number of short hospitalizations. Cardiac and neurological complaints however, made up 27.4% of the short hospitalizations.
Conclusions
short hospitalizations in medical wards have special characteristics that may render them predictable. Lowering the ED load may decrease short hospitalizations. Referring patients with cardiac and neurological complains to short term units may decrease the rate of short hospitalizations in the medical wards and improve the care in these wards.
Reappraisal of the volcanic source of the widespread Rocourt Tephra in Belgium (78 – 80 ka)
Authors: Pouclet Andre , Juvigné Etienne , Pouclet André , Pirson Stéphane , Bardintzeff Jacques-Marie 
Published: March 2024

Abstract
The Rocourt Tephra (RT) is a widespread stratigraphic marker distributed in Germany, Belgium and the Netherlands, where it is used for stratigraphic correlations, dating of host sediments and of Middle Palaeolithic archaeological assemblages, sometimes including Neandertal remains. Its age is estimated between 78 and 80 ka. This tephra has been linked to the West Eifel Volcanic Field in Germany, but its corresponding source volcano is unknown. Such a discovery would make it possible to confirm or specify the age of the tephra, because this source volcano could be dated by various methods. It would also be possible to know the composition of the magma, which cannot be determined from the altered clasts of the tephra, as well as the original mineralogical composition, thereby strengthening the validity of the marker by providing more distinctive data. Two Eifel volcanoes have been cited as potential sources, the Dreiser Weiher and the Pulvermaar, based on their large sizes and broadly similar compositions. A study of the tephra layers derived from these two known volcanoes was carried out to compare their mineral compositions with that of the Rocourt Tephra. Neither of the two volcanoes can be the source of the RT.
Microbiome Diversity and Variations in Industrial Hemp Genotypes
Authors: Ahmad Waqar , Coffman Lauryn , Ray Ram , Balan Venkatesh , Weerasooriya Aruna , Khan Abdul Latif 
Published: March 2024

Abstract

Microorganisms like bacteria and fungi are crucial for host medicinal plant growth and development. However, environmental factors and host genotypes can influence microbiome composition and diversity in plants such as industrial hemp (Cannabis sativa L.), which can help us understand how they cope with climatic stresses and pathogenic attacks. We evaluated the endophytic and rhizosphere microbial communities of two cannabidiol (CBD; Sweet Sensi and Cherry Wine) and two fibers (American Victory and Unknown). The four hemp varieties showed significant variation in microbiome diversity. The roots had significantly abundant fungal and bacterial endophyte diversity indices, whereas the stem had higher fungal than bacterial diversity. Interestingly, the soil system showed no significant diversity variation across CBD vs. fiber genotypes. In fungal phyla, Ascomycota, Basidiomycota, and Mucuromycota were significantly more abundant in root and stem than leaves in CBD-rich genotypes compared to fiber-rich genotypes. The highly abundant bacterial phyla were Proteobacteria, Acidobacteria, and Actinobacteria. We found 16 and 11 core-microbiome bacterial and fungal species across genotypes, respectively. Sphingomonas, Pseudomonas, and Bacillus were the core bacterial microbiome of fiber genotypes with high abundance compared to CBD genotypes. Contrarily, Microbacterium, and Rhizobium were significantly higher in CBD than fiber. The Alternaria and Gibberella formed core-fungal microbiome of fiber-genotype than CBD. Contrarily, Penicillium, and Nigrospora were significantly more abundant in CBD than fiber genotypes. In conclusion, specific hemp genotypes recruit specialized microbial communities. Utilizing the core-microbiome species can help to maintain and improve the growth of hemp plants and to target specialized traits of the genotype.
Shedding light on bacterial fitness in a tug-of-war with liquid
crystal emulsions
Authors: Kolle Mathias , Vijayamohanan Harikrishnan , Feldstein Hannah , Totz Jan , Concellon Alberto , Li Jie , Swager Tim 
Published: March 2024

Abstract
Rapid and reliable quantification of bacterial dynamics at the cellular level is critical for pathogen sensing, live-dead bacterial assays, and monitoring of bacteria fitness and viability. Here, we demonstrate bacterial fitness quantification by capturing individual cells on topological defects of micro-scaleliquid crystal emulsion droplets. The emulsion droplets are composed of phase-separated nematic liquid crystal and fluorocarbon components and exhibit an asymmetric mass distribution. A topological singularity in the director field of the liquid crystal phase localizes tailormade surfactants that tether a single bacterium per droplet. Active motion of the bacterium induces a tilt and azimuthal rotation of the droplet trap, which is counteracted by gravity acting on the droplet center of mass. By comparing the observed dynamics of a tethered bacterium’s stochastic movement to a computational model of bacterial motion on spherical surfaces that is based on the classical Ornstein-Uhlenbeck process, we quantify the fitness of bacteria subjected to starvation over several days. This pathogen fitness sensing concept, which relies on the scalable chemical design of single bacterial cell traps, a robust optical readout, and a theoretical understanding of bacterial dynamics on spherical surfaces, offers opportunities for rapid pathogen activity assessment, micro-biological sensing, and biologically
powered micro-actuator systems.
OTULIN-related conditions: Report of a new case and review of the literature using GenIA
Authors: Caballero-Oteyza Andrés , Crisponi Laura , Peng Xiao P. , Wang Hongying , Mrovecova Pavla , Olla Stefania , Siguri Chiara , Marnissi Farida , Jouhadi Zineb , Aksentijevich Ivona , Grimbacher Bodo , Proietti Michele 
Published: March 2024

Abstract

OTULIN encodes an eponymous linear deubiquitinase (DUB), which through the regulation of M1-Ub dynamics, is essential for controlling inflammation as a negative regulator of the canonical NF-𝛋B signaling pathway. Biallelic loss-of-function (LOF) mutations in OTULIN cause an autosomal recessive condition named Otulin-Related Autoinflammatory Syndrome (ORAS), also known as Otulipenia or AutoInflammation, Panniculitis, and Dermatosis Syndrome (AIPDS). Monoallelic OTULIN LOF, also known as OTULIN Haploinsufficiency (OHI) or Immunodeficiency 107 (IMD107), has been linked to an incompletely penetrant, dominantly inherited susceptibility to invasive Staphylococcal infections. At the same time, a recent novel ORAS-like inflammatory syndrome was described in association with a heterozygous missense mutation that appears to exert dominant negative effects. In this manuscript, we report the identification of a novel homozygous missense mutation, c.595T>A; p.(Trp199Arg), in a Moroccan infant with an ORAS phenotype. We go on to systematically review the literature for OTULIN-related human disease phenotypes by using the GenIA databaseto collect, extract and harmonize all clinical, laboratory and functional data for published patients and variants. Our comprehensive synthesis of genotypic, phenotypic, and mechanistic data enables a more in-depth view of the diverse mechanisms and pathways by which the OTULIN pathogenic variants may lead to human immune disease. This review may help variant classification activities and the drafting of diagnostic and management guidelines; but it also identifies outstanding knowledge gaps and raises additional questions for future investigation.
The role of adsorbent microstructure and itspacking arrangement in optimising theperformance of an adsorption column
Authors: Salamanca Abel Valverde , Griffiths Ian M. 
Published: March 2024

Abstract

Physical adsorption takes place inside narrow pores where the attractive interac-tion between the surface of the adsorbent and the contaminant molecules is strongenough to retain the molecules. Adsorption columns involve a range of mass-transport mechanisms: advection through the free spaces between the adsorbentpellets, diffusion through the wider pores of the adsorbent, and adsorption at thesurface, where the narrower pores exist. The adsorbent specifications along withits assembly within the sorption column are key factors when optimizing the fil-tration of pollutants. In this work we present a mathematical model based onadvection–diffusion equations coupled with Langmuir kinetics that accounts fora geometrical approach to the porosity structure inside the adsorbent and thechannels through which the fluid flows. The model is tested using typical lab-scalevalues, and we use it to identify potential design optimisation of the adsorbentmass and its assembly.
Air conditioning of an off-grid remote school with an earth to air heat exchanger coupled indirectly to a solar cooling system
Authors: Ríos Juan , Velázquez Nicolás , Aguilar-Jiménez J.A. , Corona J.A. , Islas S. , Reyes-López J.A. , Luna A. 
Published: March 2024

Abstract

This work presents the results of indirectly coupling an Earth to Air Heat Exchanger to a 35 kW absorption cooling system. The study considers the weather, building, and soil conditions of a school located in the off-grid remote community of Puertecitos, Baja California, Mexico. TRNSYS simulation software was used to analyze the thermal behavior of the Earth to Air Heat Exchanger under different operation modes, in order to reduce the thermal load of the classrooms. The results show that during the months of May and June an Earth to Air Heat Exchanger with a diameter of 0.15 m, operating from Mondays to Fridays with and mass flow of 715 kg/h, is capable to reduce the thermal load of each classroom by 268.4 kWht, equivalent to 25% of the energy to be removed for maintaining the classrooms at 25°C, which is reflected in a reduction of 12.89% and 18.25% of the electrical energy and water consumption, respectively. For the period from August to October, the thermal load was reduced by 225.2 kWht, equivalent to 15.4% of the energy to be removed for maintaining the classrooms temperature at 25°C, causing an increase of 1.33% in electrical energy consumption, but reducing the consumption of auxiliary heat and water by 94.82% and 11.07%, respectively. The annual savings in auxiliary heat, electrical energy and water are 513.52 kWht, 136.05 kWhe and 6,084.03 kg, which represent 94.82%, 4.61% and 14.3% of the annual consumption of these resources.
Association of TYR Gene Polymorphisms with Coat Colors in Chinese Raccoon Dog
Authors: Guo Ruonan , Yang Yahan , Wang Yuanyuan , Liu Jiahui , Qu Xinyu , Huang Qingkun , Yang Tong’ao 
Published: March 2024

Abstract
Background
The TYR gene has been documented to exhibit an association with the dominant white coat color in certain mammalian species. To understand the genotypic profile underlying coat color in Chinese wild-type raccoon dogs and white mutant raccoon dogs, TYR gene was amplified and variations in them were analyzed by DNA sequencing.
Results
In this study, Sequence analysis revealed that 11 single nucleotide polymorphisms SNPs were detected, and four of them were missense mutations (c.329A > G、c.479A > G、c.1497G > C、c.1523A > C) resulting in amino acid mutations (Cln110Arg, Asn160Ser, Cys1497Phe, His1523Pro). These four SNPs showed a low-to-moderate PIC value ranging from 0 to 0.351. The genotype distribution of all mutations in two raccoon populations of different coat color not reached significant level (p>0.05).
Conclusion
Overall, the results of this study suggest that TYR gene may lead to a mutation in raccoon dogs fur color to white.
Optimizing the proportion of GGBS, fly ash, and nano silica in the replacement of SCGC
Authors: Mallia Bhanu Priya , Garanayak Lasyamayee , Basa Bidyadhar , Tiadi Narayan 
Published: March 2024

Abstract

This study aims to investigate and optimize the proportion of Ground Granulated Blast Furnace Slag (GGBS), fly ash, and Nano silica in the replacement of Self-Compacting Geo-Polymer Concrete (SCGC) to enhance its performance in terms of strength, workability, and durability. The research focuses on evaluating the fresh properties of Normal Self-Compacting Concrete (SCC) and Self-Compacting Geo-Polymer Concrete (GPC) using NaOH and Na2SiO3 as activating agents. Tests such as slump flow, slump flow T50 cm, J-ring, v-funnel, v-funnel at t5 min, and L-box were conducted to assess the flow ability, passing ability, and workability of the concrete mixes. The results of the tests indicate that the concrete mixes largely satisfy the EFNARC Guidelines, with the optimized mix designs showing promising results. The slump flow values, T500mm slump flow time, V-funnel values, and L-box test results were within the specified range, demonstrating the suitability and effectiveness of the optimized mixes. The findings highlight the impact of GGBS content and Nano Silica addition on the flow and passing ability of the concrete mixes.
The progeny production from a single Myzus persicae was dependent on aphid density on Arabidopsis thaliana’s foliage
Authors: Mondal Hossain Ali , Paul Bablu , Ahmad Farzana , Gurung Albina , Mallick Moumita 
Published: March 2024

Abstract
A rapid colony formation on crop foliage is a highly relevant issue on agricultural and horticultural yield loss. Arabidopsis thaliana-Myzus persicae interaction model was explored for monitoring of the progeny production from a single aphid from an elevated level of an initial aphid densities like five, ten and twenty aphids’ release. The hypothesis was that each aphid contributed an equal number of progenies from every inoculum. The progeny production per aphid is also linked to host resistance and inversely corelated. To test this hypothesis, three different aphids’ density like five, ten and twenty adult aphids were inoculated with six biological replications on Arabidopsis thaliana foliage to monitor progeny proliferation from a single aphid in temporal scale like 0-, 12-, 24-, 36-, 60- and 108-hours’ time points after release. From the result, it was found that progeny contribution from a single aphid was dependent on aphid density on foliage. Another parameter, the marginal progeny production from a single aphid was also aphid density dependent. Thus, host resistance response was dependent on aphid density. In another perspective, aphids on host foliage were not independent, rather they communicated to each other through vascular sap. Therefore, the aphid density mediated herbivore on vascular sap was ‘footprinted’ in a density dependent manner and may be treated as molecular language among aphids.
Superiority of neutrophil count over other inflammatory markers in predicting gestational diabetes: A prospective cohort study
Authors: Hashemipour Sima , kalantarian Seyedeh Sareh , Panahi Hamidreza , Kelishomi Sara Esmaeili , Ghasemi Amirabbas , Chopani Sarah Mirzaeei , Kolaji Sepideh , Badri Milad , Ghobadi Arefeh , khairkhahan Seyyed Mohammad Reza Hadizadeh , Lalooha Fatemeh , Movahed Farideh , Abbasi Mahnaz , Elmizadeh Khadijeh 
Published: March 2024

Abstract

Background: To investigate the predictive values of blood cell components and blood cells-derived inflammatory indices for predicting gestational diabetes mellitus (GDM).
Methods: This study is part of the Qazvin Maternal and Neonatal Metabolic Study (QMNMS) in Iran (2018-2021. The association of blood cells and blood cell-derived inflammatory indices including neutrophil to lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), systemic immune inflammation index (SII), and aggregate systemic inflammatory response index (AISI) in early pregnancy with early insulin resistance and development of GDM in following months was investigated using univariate and multivariate statistical analysis.
Results: The final analysis was performed on 612 participants. GDM developed in 96 participants (15,7%). In univariate analysis, neutrophil quartiles had the highest predictive value for GDM development. Lymphocytes and monocytes quartiles were not associated with GDM development. In the fully adjusted model, neutrophil quartiles remained the strongest predictors of GDM development with relative risks of 3.7, 4.2, and 8.3 for 2nd, 3rd, and 4th neutrophil quartiles compared to the first quartile (P<0.001). Other inflammatory indices including NLR, SIRI, SII, and AISI had no additional yield to predict GDM. Despite the strong associate of neutrophil quartiles with GDM, there was no association between neutrophil counts and early pregnancy insulin resistance assessed by Homeostasis of Model Assessment -Insulin Resistance (HOMA-IR).
Conclusion: Neutrophil count is the best predictor of GDM development among blood cell components and blood cell-derived inflammatory indices. The role of neutrophils in GDM development is independent of early pregnancy insulin resistance.
Aquaponic growth of basil (Ocimum basilicum) with African catfish (Clarias gariepinus) in standard substrate combined with a Humicacid Fiber-Substrate (HFS)
Authors: Knaus Ulrich , Hübner Hyo-Dschung Dirk , Küchenmeister Christian , Appelbaum Samuel , Iten Walter , Palm Harry W. 
Published: March 2024

Abstract

A major challenge in agriculture, horticulture and aquaponics practices is the reduction of mineral fertilisers and peat to reduce CO2 emissions and increase sustainability. This study used a three-phase-natural fertiliser, the Humicacid Fiber-Substrate (HFS), made from natural regenerative organic and mineral-fractions (Humus-Mineral-Complex), to reduce the peat content in plant pots for aquaponics farming. Basil (Ocimum basilicum) growth was compared with i) 100% standard media substrate ("Einheitserde", white peat 80%, clay 20%), and ii) 85% "Einheitserde" and 15% of HFS under irrigation with aquaculture process waters from an extensive and intensive production of African catfish (Clarias gariepinus) under coupled aquaponic conditions. The substitution with 15% HFS and use of intensive fish water resulted in comparable plant growth to a fertiliser solution as control, and in higher leaf width and leaf green weight and lower root dry weight compared with the standard media substrate "Einheitserde". Basil leaf chlorophyll content from the aquaponics was higher compared with local market plants. This suggests the possible substitution of the peat substrate "Einheitserde" with at least 15% HFS to reduce the natural peat fraction. Further studies on crop-specific substrates are needed to reduce peat in aquaponics farming plant cultivation.