bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis Of Competency, Compensation, And Work Environment On Employee Performance With Satisfaction Employment As An Intervening Variable (Case Study of the Department of Industry, Trade, Energy and Mineral Resources North Sumatra Province)
Authors: Cut Maulita  , Mesra B  
Published: February 2024

This study aims to test and analyze the influence of competency (X1), compensation (X2), and work environment (X3) on employee performance (Y) which is mediated by satisfaction (Z). The population in this study was consumers with 120 samples taken. The research was conducted from December 2023 to Januari 2024. This study used quantitative data which was processed using SEM-PLS analysis model with Smart PLS 3.0. application. Data sources used primary data taken directly from respondents and secondary one was obtained from interviews with employees in the Department of Industry, Trade, Energy and Mineral Resources North Sumatra Province. The results of the research show that competence has a positive and significant effect on satisfaction. Compensation has a positive and insignificant effect on satisfaction, the work environment has a positive and insignificant effect on satisfaction. Satisfaction has a positive and insignificant effect on employee performance. The work environment has a positive and significant effect on employee performance. Competency has a positive and significant effect on employee performance. Compensation has a positive and insignificant effect on employee performance.
Atish-e Zaban: The Intercultural Musical Language of Sandeep Bhagwati and the Modalities of the Human Voice
Authors: Tabandeh Roozbeh 
Published: February 2024

This article is a musical analysis and formal study of Sandeep Bhagwati’s piece, Atish-e Zaban (composed and premiered in 2006). It touches on modalities of composing vocal music and, in particular, aspects of Bhagwati’s methods for creating intercultural encounters and sonic situations. Atish-e Zaban is a comprovisation piece scored for six a capella new music singers based on a series of poems in Urdu by the Pakistani poet, Faiz Ahmad Faiz (1911-1984). This text uncovers layers of Bhagwati’s overall approach to vocal composition, providing an analytic guide for listening and performing, and describing the comprovisation methods used to express the connotations of the poems.
Long-term Clinical and Radiographic Outcomes Following Surgical Treatment for Ankle Fracture-Dislocations: Do poor radiographic outcomes always matter?
Authors: Pehlivanoglu Tuna , Demirel Mehmet , Koyuncu Daghan , Valiyev Natiq , Akgül Turgut , Kilicoglu Onder Ismet 
Published: February 2024

Abstract
Background Ankle fractures constitute 10% of all traumatic fractures in clinical practice. Concurrent tibiotalar dislocations form 21-36% of all ankle fractures. Although mechanism of injury is similar to non-dislocated ankle fractures, fracture-dislocations cause more extensive bone and soft tissue damage. Treatment is a challenge for orthopedic surgeons due to concomitant pathologies. It is associated with malreduction, chronic pain and most importantly, posttraumatic osteoarthritis. We aimed to investigate the relationship between ankle osteoarthritis radiographic stage and clinical outcomes.
Methods 27 patients (17 female, 10 male) were included in the study. Records and data were retrospectively analyzed. Clinical status at the final follow-up was evaluated by a single orthopedic surgeon. Range of motion (ROM), American Orthopedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score, visual analogue scale (VAS) were the clinical parameters that were assessed. Radiological assessment was made by standard anteroposterior [AP], lateral, and mortise views. Pre-operative osseo-ligamentous injury pattern, presence of posterior malleolar fracture, syndesmosis injury and post-operative ankle osteoarthritis were investigated.
Results For 27 patients that were evaluated, at the final follow-up, mean AOFAS was 85 ± 8.12, and mean VAS during daily activities was 1.52 ± 0.70. Mean ankle dorsiflexion and plantar flexion were significantly lower on the affected sides (14.07 ± 7.97° and 36.30 ± 6.59°) than on the unaffected sides (28.15 ± 2.82° and 46.30 ± 2.97°), respectively (p < 0.001). No significant difference for inversion and eversion was observed. Twenty-four patients demonstrated radiographic signs of ankle osteoarthritis, and three remained without evidence of osteoarthritis. No significant difference was found among Takakura’s stages in any of the variables.
Conclusion The results illustrated that although post-traumatic osteoarthritis rate was high for ankle fracture-dislocation patients, surgical treatment achieved excellent functional results. Even if advanced stages of ankle arthritis according to Takakura’s classification developed, patients had satisfactory clinical and functional results.
Multiscale transport and 4D time-lapse imaging in precision-cut liver slices (PCLS)
Authors: Azam Iqra , Benson James D. 
Published: February 2024

Background
Monitoring cellular processes across different levels of complexity, from the cellular to the tissue scale, is important for understanding tissue structure and function. However, it is challenging to monitor and estimate these structural and dynamic interactions within three-dimensional (3D) tissue models.

Objective
The aim of this study was to design a method for imaging, tracking, and quantifying 3D changes in cell morphology (shape and size) within liver tissue, specifically a precision-cut liver slice (PCLS). A PCLS is a 3D model of the liver that allows the study of the structure and function of liver cells in their native microenvironment.

Methods
Here, we present a method for imaging liver tissue during anisosmotic exposure in a multispectral four-dimensional manner. Three metrics of tissue morphology were measured to quantify the effects of osmotic stress on liver tissue. We estimated the changes in the volume of whole precision cut liver slices, quantified the changes in nuclei position, and calculated the changes in volumetric responses of tissue-embedded cells.

Results
During equilibration with cell-membrane-permeating and non-permeating solutes, the whole tissue experiences shrinkage and expansion. As nuclei showed a change in position and directional displacement under osmotic stress, we demonstrate that nuclei could be used as a probe to measure local osmotic and mechanical stress. Moreover, we demonstrate that cells change their volume within tissue slices as a result of osmotic perturbation and that this change in volume is dependent on the position of the cell within the tissue and the duration of the exposure.

Conclusion
The results of this study have implications for a better understanding of multiscale transport, mechanobiology, and triggered biological responses within complex biological structures.
A microdeletion in Xp11.3 accounts for co‐segregation of retinitis pigmentosa and mental retardation in a large kindred
Authors: Zhang Lilei , Wang Tao , Wright Alan F. , Suri Mohnish , Schwartz Charles E. , Stevenson Roger E. , Valle David 
Published: January 2006

AbstractIn a previous report, Aldred et al. [1994] described a 5‐generation family in which severe retinitis pigmentosa (RP) co‐segregates with mild–moderate mental retardation as an X‐linked recessive phenotype mapping to the broad interval between Xp21‐q21. We re‐examined this family, initially analyzing RP2, a gene in the disease interval that was identified as a cause of RP after the initial report of this family. We found that the male propositus lacked the 5′ three exons of RP2 and that RP2 marks the centromeric boundary of a 1.27 Mb deletion that includes two other annotated genes (SLC9A7, CHST7), one predicted transcript encoding a zinc finger protein (FLJ20344) and two highly conserved miRNAs (mir221, mir222). We conclude that this family is segregating a contiguous gene deletion and that the absence of a functional RP2 accounts, at least in part, for the retinal degeneration while deletion of one or more of the other genes is likely responsible for the mental retardation phenotype. © 2006 Wiley‐Liss, Inc.
Association of Jacobsen syndrome and bipolar affective disorder in a patient with a de novo 11q terminal deletion
Authors: Böhm D. , Hoffmann K. , Laccone F. , Wilken B. , Dechent P. , Frahm J. , Bartels I. , Bohlander S.K. 
Published: January 2006

AbstractWe report on a young woman with Jacobsen syndrome (JBS) who was admitted to our psychiatric department because of a bipolar affective disorder (BPAD). Chromosome analysis was performed due to the fact that she had mental retardation, short stature, and subtle facial anomalies. A deletion of the distal long arm of chromosome 11 was found. A detailed mapping of the deletion breakpoint by quantitative real time PCR revealed a true terminal 11q deletion of approximately 8 Mb corresponding to the karyotype 46,XX,del(11)(q24.2). Polymorphic DNA marker analysis showed that the deletion is located on the paternal chromosome. Additionally, laboratory investigations revealed a low platelet count and magnetic resonance imaging of the brain showed white matter T2 hyperintensities in frontotemporal regions, which are unlikely to result from a demyelinating process as indicated by localized proton magnetic resonance spectroscopy. To our knowledge, this is the first report describing a BPAD in a case with JBS. © 2006 Wiley‐Liss, Inc.
Schimke immuno‐osseous dysplasia: A cell autonomous disorder?
Authors: Elizondo Leah I. , Huang Cheng , Northrop Jennifer L. , Deguchi Kimiko , Clewing Johanna M. , Armstrong Dawna L. , Boerkoel Cornelius F. 
Published: January 2006

AbstractSMARCAL1 (SWI/SNF‐related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily a‐like protein 1) encodes a SWI/SNF ATP‐dependent chromatin remodeling protein. Mutations in SMARCAL1 cause the autosomal‐recessive multisystem disorder Schimke immuno‐osseous dysplasia (SIOD); this suggests that the SMARCAL1 protein is involved in the development or maintenance of multiple organs. Disease within these many tissues could arise by a cell autonomous or a cell non‐autonomous mechanism. Consistent with a cell autonomous mechanism, we did not find any disease recurrence in transplanted organs or protection of other tissues by the organ grafts. In order to better understand the role of SMARCAL1 during normal development and in the pathogenesis of SIOD, we characterized the spatial and temporal expression of the murine homolog (Smarcal1). The Smarcal1 mRNA and protein were expressed throughout development and in all tissues affected in patients with SIOD including the bone, kidney, thymus, thyroid, tooth, bone marrow, hair, eye, and blood vessels. Significantly, the expression profile of Smarcal1 in the mouse has led us to reexamine and identify novel pathology in our patient population resulting in changes in the clinical management of SIOD. The expression of Smarcal1 in affected tissues and the non‐recurrence of disease in grafted organs lead us to hypothesize a cell autonomous function for SMARCAL1 and to propose tissue‐specific mechanisms for the pathophysiology of SIOD. © 2006 Wiley‐Liss, Inc.
Andersen‐Tawil syndrome: Prospective cohort analysis and expansion of the phenotype
Authors: Yoon G. , Oberoi S. , Tristani‐Firouzi M. , Etheridge S.P. , Quitania L. , Kramer J.H. , Miller B.L. , Fu Y.H. , Ptáček L.J. 
Published: January 2006

AbstractAndersen‐Tawil syndrome (ATS) is an autosomal dominant multisystem disorder characterized by developmental, cardiac, and neuromuscular abnormalities. Approximately 70% of patients have mutations in KCNJ2, resulting in dysfunction of the inward‐rectifying potassium channel Kir2.1. Variable expression complicates the diagnosis of ATS, which in many cases, is not made until years after the first recognized symptom. To better define the distinctive clinical features of ATS and facilitate earlier diagnosis, we conducted a prospective, standardized evaluation of 10 subjects with confirmed KCNJ2 mutations. Detailed anthropometric, neurological, and cardiac evaluations were performed. Using this approach, we identified novel skeletal and dental findings and proposed additional diagnostic criteria for ATS dysmorphology. © 2006 Wiley‐Liss, Inc.
Narrowing candidate region for monosomy 9p syndrome to a 4.7‐Mb segment at 9p22.2‐p23
Authors: Kawara Hiroki , Yamamoto Toshiyuki , Harada Naoki , Yoshiura Koh‐ichiro , Niikawa Norio , Nishimura Akira , Mizuguchi Takeshi , Matsumoto Naomichi 
Published: January 2006

AbstractA 2‐year‐old boy with clinical manifestations of monosomy 9p syndrome and brown hair is described. G‐banding and chromosome FISH studies demonstrated complex rearrangements involving seven breakpoints in chromosomes 2 and 9, which included a 6.6‐Mb deletion at 9p22.2‐p23. This, together with previous studies in the literature, narrowed the shortest region of overlap (SRO) for the syndrome to a 4.7‐Mb interval. Candidate genes for trigonocephaly, mental retardation, and brown hair are discussed. © 2006 Wiley‐Liss, Inc.
Current perspectives on the genetic analysis of autism
Authors: Coon Hilary 
Published: January 2006

AbstractAlthough no definitive genetic mutations leading to autism susceptibility have been established, the field has many new resources to tackle this difficult problem. Numbers of families at many research sites are now large, and new collaborations among these groups will allow for collections of subjects with enough statistical power to detect relatively small gene effects. New technological advances in genotyping will allow for more fine‐grained genetic analysis, and more sophisticated techniques have been developed to address the vast amounts of data acquired. Researchers have also begun to focus on intermediate phenotypes associated with autism, such as elevated serotonin, increased head circumference, social difficulties, or language impairment or delay. These phenotypes may help to stratify affected cases into more genetically homogeneous subgroups, and may also occur in their clinically unaffected relatives. The study of intermediate phenotypes may allow investigators to find common gene variants that lead to autism susceptibility. Here we discuss the major intermediate phenotypes, and give an overview of current genetic analysis techniques. © 2006 Wiley‐Liss, Inc.
How a judge's overzealousness will help redefine mediation limits
Authors: Kichaven Jeff 
Published: January 2006

AbstractAlternatives editorial board member Jeff Kichaven, of Los Angeles, examines what he notes is the defining California appellate court decision of 2005, Travelers Casualty and Surety Co. v. Superior Court. The judge in the case proposed mediation and designed a system to deal with claims stemming from accusations against the Catholic Church involving sexual abuse. But a state appeals court found that the judge's good idea was coercive. Kichaven discusses why the judge's mistakes likely will benefit mediation over the long term.
Characterization of neurochemically specific projections from the locus coeruleus with respect to somatosensory‐related barrels
Authors: Simpson Kimberly L. , Waterhouse Barry D. , Lin Rick C.S. 
Published: January 2006

AbstractTactile information from the rodent mystacial vibrissae is relayed through the ascending trigeminal somatosensory system. At each level of this pathway, the whiskers are represented by a unique pattern of dense cell aggregates, which in layer IV of cortex are known as “barrels.” Afferent inputs from the dorsal thalamus have been demonstrated repeatedly to correspond rather precisely with this modular organization. However, axonal innervation patterns from other brain regions such as the noradrenergic locus coeruleus are less clear. A previous report has suggested that norepinephrine‐containing fibers are concentrated in the center/hollow of the barrel, while other studies have emphasized a more random distribution of monoaminergic projections. To address this issue more directly, individual tissue sections were histochemically processed for cytochrome oxidase in combination with dopamine‐β‐hydroxylase, the synthesizing enzyme for norepinephrine, or the neuropeptide galanin. These two neuroactive agents were of particular interest because they colocalize in a majority of locus coeruleus neurons and terminals. Our data indicate that discrete concentrations or local arrays of dopamine‐β‐hydroxylase‐ or galanin‐immunoreactive fibers are not apparent within the cores of individual barrels. As such, the data suggest that cortical inputs from the locus coeruleus are not patterned according to cytoarchitectural landmarks or the neurochemical identity of coeruleocortical efferents. While transmitter‐specific actions of norepinephrine and/or galanin may not be derived from the laminar/spatial connections of locus coeruleus axons, the possibility remains that the release of these substances may mediate distinctive events through the localization of different receptor subclasses, or the contact of their terminals onto cells with certain morphological characteristics or ultrastructural components. © 2006 Wiley‐Liss, Inc.
Web navigation support by means of proximity‐driven assistant agents
Authors: Loia Vincenzo , Pedrycz Witold , Senatore Sabrina , Sessa Maria I. 
Published: January 2006

AbstractThe explosive growth of the Web and the consequent exigency of the Web personalization domain have gained a key position in the direction of customization of the Web information to the needs of specific users, taking advantage of the knowledge acquired from the analysis of the user's navigational behavior (usage data) in correlation with other information collected in the Web context, namely, structure, content, and user profile data. This work presents an agent‐based framework designed to help a user in achieving personalized navigation, by recommending related documents according to the user's responses in similar‐pages searching mode. Our agent‐based approach is grounded in the integration of different techniques and methodologies into a unique platform featuring user profiling, fuzzy multisets, proximity‐oriented fuzzy clustering, and knowledge‐based discovery technologies. Each of these methodologies serves to solve one facet of the general problem (discovering documents relevant to the user by searching the Web) and is treated by specialized agents that ultimately achieve the final functionality through cooperation and task distribution.
Concept‐matching IR systems versus word‐matching information retrieval systems: Considering fuzzy interrelations for indexing Web pages
Authors: Garcés Pablo J. , Olivas José A. , Romero Francisco P. 
Published: January 2006

AbstractThis article presents a semantic‐based Web retrieval system that is capable of retrieving the Web pages that are conceptually related to the implicit concepts of the query. The concept of “concept” is managed from a fuzzy point of view by means of semantic areas. In this context, the proposed system improves most search engines that are based on matching words. The key of the system is to use a new version of the Fuzzy Interrelations and Synonymy‐Based Concept Representation Model (FIS‐CRM) to extract and represent the concepts contained in both the Web pages and the user query. This model, which was integrated into other tools such as the Fuzzy Interrelations and Synonymy based Searcher (FISS) metasearcher and the fz‐mail system, considers the fuzzy synonymy and the fuzzy generality interrelations as a means of representing word interrelations (stored in a fuzzy synonymy dictionary and ontologies). The new version of the model, which is based on the study of the cooccurrences of synonyms, integrates a soft method for disambiguating word senses. This method also considers the context of the word to be disambiguated and the thematic ontologies and sets of synonyms stored in the dictionary.
Image clustering for the exploration of video sequences
Authors: Torra Vicenç , Lanau Sergi , Miyamoto Sadaaki 
Published: January 2006

AbstractIn this article we present a system for the exploration of video sequences. The system, GAMBAL for the Exploration of Video Sequences (GAMBAL‐EVS), segments video sequences, extracting an image for each shot, and then clusters such images and presents them in a visualization system. The system allows the user to find similarities between images and to proceed through the video sequences to find the relevant ones.
Construction and evaluation of a kinetic scheme for RecA‐mediated DNA strand exchange
Authors: Xiao Jie , Lee Andrew M. , Singleton Scott F. 
Published: January 2006

AbstractThe Escherichia coli RecA protein is the prototype of a class of proteins playing a central role in genomic repair and recombination in all organisms. The unresolved mechanistic strategy by which RecA aligns a single strand of DNA with a duplex DNA and mediates a DNA strand switch is central to understanding its recombinational activities. Toward a molecular‐level understanding of RecA‐mediated DNA strand exchange, we explored its mechanism using oligonucleotide substrates and the intrinsic fluorescence of 6‐methylisoxanthopterin (6MI). Steady‐ and presteady‐state spectrofluorometric data demonstrate that the reaction proceeds via a sequential four‐step mechanism comprising a rapid, bimolecular association step followed by three slower unimolecular steps. Previous authors have proposed multistep mechanisms involving two or three steps. Careful analysis of the differences among the experimental systems revealed a previously undiscovered intermediate (N1) whose formation may be crucial in the kinetic discrimination of homologous and heterologous sequences. This observation has important implications for probing the fastest events in DNA strand exchange using 6MI to further elucidate the molecular mechanisms of recombination and recombinational repair. © 2006 Wiley Periodicals, Inc. Biopolymers 81: 473–496, 2006This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Classification of lactic acid bacteria with UV‐resonance Raman spectroscopy
Authors: Gaus K. , Rösch P. , Petry R. , Peschke K.‐D. , Ronneberger O. , Burkhardt H. , Baumann K. , Popp J. 
Published: January 2006

AbstractUV‐resonance Raman spectroscopy is applied as a method for the identification of lactic acid bacteria from yogurt. Eight different strains of bacteria from Lactobacillus acidophilus, L. delbrueckii ssp. bulgaricus, and Streptococcus thermophilus were investigated. At an excitation wavelength of 244 nm signals from nucleic acids and proteins are selectively enhanced. Classification was accomplished using different chemometric methods. In a first attempt, the unsupervised methods hierarchical cluster analysis and principal component analysis were applied to investigate natural grouping in the data. In a second step the spectra were analyzed using several supervised methods: K‐nearest neighbor classifier, nearest mean classifier, linear discriminant analysis, and support vector machines. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 286–290, 2006This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com