bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repensando o feminismo com Françoise Vergès - perspectivas do Sul Global
Authors: Da Silva Alana Pereira 
Published: April 2024

Para pensar em um feminismo descolonizador, Françoise Vergès se aproxima das produções intelectuais do Sul Global e realiza um diálogo com intelectuais africanas, latino-americanas e asiáticas. O feminismo decolonial concentra esforços em analisar os problemas sociais ocasionados pela colonialidade. Desse modo, Françoise Vergès ressalta a importância de um feminismo militante que traga à tona as estruturas racistas do Estado através da luta coletiva. Nesse sentido, a luta deve continuar sendo sobre equidade de gênero, mas enquanto este movimento não reconhecer o racismo de uma luta que se cristaliza apenas no gênero, mulheres racializadas permanecerão em situação de vulnerabilidade, o que denmostra que o feminismo, nesses moldes, precisa ser repensado.
Peningkatan Prestasi Belajar PKn melalui Metode Kooperatif Pada Siswa SD
Authors: Suhartini Christina 
Published: April 2024

<p>Abstract. The formulation of the problem in this study is whether the cooperative method can be used to improve PKn learning achievement for grade IV students of SD Negeri 2 Nanggulan, District of Cawas, Klaten Regency, second semester 2017/2018 academic year? The goal to be achieved is to prove that the cooperative method can be used to improve PKn learning achievement of grade IV students of SD Negeri 2 Nanggulan, District of Cawas, Klaten Regency, second semester of the school year 2017/2018. This research was conducted at Nanggulan Cawas Klaten Public Elementary School 2. While the time of the study was<br />conducted from February to March 2018. The subjects of this study were grade IV students of SD Negeri 2 Nanggulan Cawas Klaten in the second semester of the school year 2017/2018. This action research uses the classroom action research flow. The data analysis technique used uses several stages, namely data reduction, presentation and conclusion. From the results of the research carried out since planning, repairs to implementation and evaluation, it can be concluded that the cooperative method can be used to improve PKn learning achievement of fourth grade students of SDN 2 Nanggulan, District of Cawas, Klaten Regency, second semester 2017/2018 school year. This was proven before the improvement in the percentage of students' completeness in learning was only 27.78% or 5 students, in the improvement of the first cycle to 55.6% (of 18 students, which was not completed 8 students) and in the second cycle the percentage of student mastery reached 94, 44%. Of the 18 students, 17 of them have achieved mastery learning, while the one student is still incomplete.</p>
Upaya Peningkatkan Prestasi Belajar tentang Sistem Periodik Unsur melalui Metode KIMLA Pada Siswa Kelas X MIPA SMA
Authors: Setyawati Happy 
Published: April 2024

<p>Abstract. The national curriculum of learning takes place through the Scientific Approach, students are guided to be able to find learning material by themselves. Not all students can be easily active in learning, because they are afraid to ask questions, lazy even some do not understand so learning is increasingly confusing. Learning with the habits of students want to explain the teacher, making students less active in the learning process and the results obtained are not optimal. Chemistry is often considered to be an elusive lesson that causes student<br />dislike. Pleasant learning methods are needed so as to create joyful nuanced learning situations that make students absorbed, comfortable and excited. The learning method chosen in this study was the KIMLA learning method, namely the method of discussion using songs as a medium in learning Chemistry. With the KIMLA method, it is expected that there will be an increase in the activeness and learning achievement of students in the periodic Chemistry System Learning subject elements. This research is a Classroom Action Research conducted at<br />SMA 1 Ceper Klaten, in the odd semester of the 2018/2019 academic year in September 2018 - October 2019, the target in this study was the tenth grade students of MIPA 1 with 28 students consisting of 12 sons and 16 daughters. Data obtained through observation are direct observations when taking student learning activities data, and assessment sheets are continued by analysis of the average pre-action test scores, cycle 1 and cycle II. The criteria for the success of giving an action are if students get a minimum score of 67 KKM, with the percentage of learning completeness 75% of 28 students, while the success criteria for learning<br />activeness are 80%. Based on the results of the research and discussion it was concluded that there was an increase in the activeness of students to 96.4% and 100% learning outcomes completed with an average of 79.</p>
Upaya Meningkatkan Kompetensi Guru dalam Menyusun Silabus melalui Bimbingan dan Supervisi di SD Negeri 1 Kalinanas
Authors: Rusmiyati S 
Published: April 2024

<p>Abstract. The purpose of this study is to improve the competence of teachers in SD<br />Negeri 1 Kalinanas in compiling learning syllabus documents. The study was conducted at SD Negeri 1 Kalinanas for ± 5 months starting July 2015 to December 2015. The number of teachers in SD Negeri 1 Kalinanas who attended Guidance and Supervision amounted to 9 teachers. Data collection is done through interviews, observation and documentation. From the interview, the results showed that overall the teachers at SD Negeri 1 Kalinanas stated that it was important to prepare the learning syllabus documents very well. The study was conducted in 2 cycles. In the pre cycle, the average value of 77 was obtained with a percentage of 52% achievement of all teachers in the syllabus preparation research indicator. In cycle 1 the average value was 84 with 67% achievement of all teachers in the syllabus preparation research indicators, and the second cycle on average 98 with a 95% percentage of achievement of all teachers in the syllabus preparation research indicators. There was an increase in teacher competency in the preparation of syllabus after Guidance and Supervision were carried out by the principal of SD 1 Kalinanas.</p>
Association between aqueous humor MMP-3 levels and varicella zoster virus-induced acute retinal necrosis
Authors: Wang Zhujian , liu yu , Zhou Min , Lei Boya , Wang Zhujian , Qing Chang 
Published: April 2024

Abstract

Objective This study aims to investigate the correlation between matrix metalloproteinase-3 (MMP-3) levels in the aqueous humor and the development of varicella-zoster virus-induced acute retinal necrosis (ARN).
Methods Twenty eyes in 20 patients diagnosed with ARN were enrolled, with all the medical records retrospectively reviewed. Aqueous humor samples were collected before the initial antiviral treatments, and MMP-3 levels were quan­tified using immunoturbidimetry. Controls consisted of fifteen eyes from age-related cataract (ARC) patients. Correla­tions between aqueous humor MMP-3 levels and ophthalmic examination results were analyzed using Spearman's cor­relation test.
Results MMP-3 were significantly higher in the aqueous humor of ARN patients compared to the controls. (P<0.001). The following correlations for aqueous humor MMP-3 levels were observed: A low negative correlation with BCVA was observed (r=-0.447, P=0.0483). A moderate positive correlation was found with the percentage of active retinal necrosis area (r=0.773, P=0.0001). A moderate negative correlation was identified with vitreous haze (r= -0.642, P= 0.0023). No significant correlation was found between MMP-3 levels and intraocular pressure or disease duration (P>0.05). The risk of retinal detachment (RD) was predicted by high MMP-3 levels (HR=4.473; 95% CI, 1.143-17.50; P=0.0314).
Conclusion It is suggested by our findings that MMP-3 may play a crucial role in the pathogenesis of ARN, and the detection of aqueous humor MMP-3 is deemed to hold clinical value for both the treatment and prognosis of ARN.
Education and Music Intervention to Reduce Anxiety: feasibility, potential efficacy and patient satisfaction in a pilot study
Authors: Batista Letícia de Carvalho , de Oliveira Milena Santos , Reis Juliana Paulucci , de Almeida Youri Eliphas , Fonseca Rafael de Jesus , Salvetti Marina de Góes , Butcher Rita de Cássia Gengo e Silva 
Published: April 2024

Abstract
Background
People undergoing cardiac catheterization experience anxiety. Musical and educational interventions have been tested separately and have been shown to reduce anxiety in this patient profile. This pilot study aimed to assess the feasibility and potential effectiveness of a complex intervention called Education and Music Intervention to Reduce Anxiety (EMIRA), in addition to participant credibility, expectations and satisfaction.
Methods
This is a randomized, blind, pilot clinical trial, carried out in an emergency department specializing in cardiology. Feasibility was assessed according to recruitment, retention, attrition and recruitment time rates. The potential for efficacy was assessed through the effect of EMIRA on state anxiety, blood pressure, heart rate, respiratory rate and chest pain intensity, comparing the intervention group (IG) and control group (CG) before (T1), immediately after (T2) and two to four hours after (T3) the intervention. To estimate participant satisfaction with the intervention, a visual numerical scale was used. Participant credibility and expectations regarding EMIRA were determined using a previously validated instrument. The significance level adopted was 5%.
Results
A total of 47 potential participants were approached over a period of 54 days. Recruitment, retention, and attrition rates were, respectively, 93.6%, 90.9%, and 10%. No participant withdrew from continuing in the study after recruitment. No significant difference was observed between CG and IG in relation to the analyzed outcomes. The mean score for satisfaction, credibility and expectations were high. There was a negative correlation between satisfaction and the difference in SBP between T1 and T2.
Conclusions
EMIRA is a complex intervention with an educational and musical component. The results suggest that a larger-scale clinical trial is feasible, participants were satisfied and had positive attitudes towards the intervention. However, EMIRA did not promote a significant change in the outcomes analyzed.
Trial registration
RBR-857nczs
Effects of ephedrine and phenylephrine on the Analgesia Nociception Index (ANI) and Nociception Level (NOL)
Authors: Kuroki Masahiro , Onodera Yu , Okada Masayuki , Nakane Masaki 
Published: April 2024

Abstract

Purpose: Nociceptive monitor values is thought to be influenced by vasopressors; however, no study has investigated this in detail. Therefore, this study aimed to investigate the effect of vasopressors on nociceptive monitors using Analgesia Nociception Index (ANI) and Nociception Level (NOL).
Methods: This prospective observational study was conducted between February and April, 2023. Data were obtained during anesthesia induction only to exclude surgical invasion. Blood pressure, heart rate, ANI, and NOL were measured 5 min after ephedrine or phenylephrine administration during hypotension. Low ANI and high NOL values indicate severe pain. Statistical analyses were performed on the values before and after vasopressor administration for each parameter.
Results: Twelve patients (male, 10; female, 2) with a mean age of 71.3 ± 6.7 years were included. ANI and NOL, before versus after ephedrine administration were 76.3 ± 11.8 versus 33.6 ± 8.1 (p < 0.001) and 2.1 ± 1.5 versus 27.6 ± 10.5 (p < 0.001), respectively. ANI and NOL, before versus after phenylephrine administration were 75.7 ± 9.2 versus 53.0 ± 15.3 (p = 0.010) and 4.0 ± 3.5 versus 21.5 ± 4.3 (p < 0.001), respectively. The mean time beyond the pain threshold (ANI < 50 and NOL > 25) for ephedrine and phenylephrine was 58.0 s and 21.0 s for ANI, and 29.3 s and 1.0 s for NOL, respectively.
Conclusion: The use of vasopressors, albeit a short time, significantly altered the nociceptive monitor values, and in some cases, exceeded the values considered to be the threshold for pain.
Salivary analysis to unveil the paradigma of stress of domestic horses reared in the wild
Authors: Bazzano Marilena , Marchegiani Andrea , Gualana Francesca La , Petriti Begi , Spaterna Andrea , Laus Fulvio 
Published: April 2024

Abstract
Horse welfare is the product of multiple factors, including behavioral and physiological adjustments to cope with stressful situation regarding environment and housing condition. Collectively, it is supposed that a horse kept in the wild has a lower level of stress than other housing system, and the aim of the present study was to investigate the level of stress in domestic horses reared in the wild and then moved to human controlled housing, through saliva analysis. Twelve clinically healthy Catria (Italian local breed) mares, usually reared in the wild, were moved into collective paddocks for a folkloric event. Saliva samples were obtained before and after the change of housing condition to evaluate stress biomarkers including salivary cortisol, salivary alpha-amylase, and butyrylcholinesterase. The mares were also scored using the Welfare Aggregation and Guidance (WAG) Tool to highlight the presence of abnormal behaviors. Despite the absence of differences in behavioral scores between wild and paddocks, salivary cortisol and butyrylcholinesterase were found to be overexpressed in the wild and statistically decreased when mares were moved to paddocks. The highest concentrations in stress biomarkers like salivary cortisol and butyrylcholinesterase in the wild was unexpected, but the need for managing hierarchical relationships, and the exposure to feral animals, predators, and weather changes, might explain these findings. The overall results of the present study may provide further knowledge toward stress response in domesticated horses living in the wild moved to human controlled housing system.
Management and Outcomes in Pulmonary Arterial Hypertension Patients with Sepsis
Authors: Flynn Spencer , Chen Haidee , Kerbel Russell , Gupta Summer , Jasuja Sonia , Saggar Rajan , Channick Richard , Sherman Alexander 
Published: April 2024

Abstract

INTRODUCTION: Sepsis is a common cause of death in patients with pulmonary arterial hypertension (PAH). Treatment requires careful fluid management and hemodynamic support. This study compares patients with or without PAH presenting with sepsis with a focus on initial fluid resuscitation.
METHODS: This retrospective analysis compared adults with and without PAH admitted for sepsis at two academic hospitals between 2013-2022. Prior PAH diagnosis was verified by review of right heart catheterization data and sepsis present on admission was verified by chart review. Demographics, vital signs, laboratory values, imaging results, treatment approaches, and all-cause mortality data were obtained. Controls were propensity score weighted by age, sex, and Charlson Comorbidity index. Logistic regression models controlling for age and Charlson comorbidity indices were used to examine factors associated with survival.
RESULTS: Thirty patients admitted for sepsis with pre-existing PAH were compared to 96 matched controls. Controls received significantly more fluids at 24 hours compared to PAH patients (mean 1503 mL v. 406 mL, p<0.001), while PAH patients were more likely to receive vasoactive medications (23.3% vs. 8.3%, p=0.037). At 30 days, 7 PAH patients (23.3%) and 13 control patients (13.5%) had died (p=0.376). PAH patients that received more fluids had decreased mortality (OR 0.93, 95% CI 0.84-0.98, p=0.03) and patients who received fluids had shorter mean time to antibiotics (2.3 hours v. 6.5 hours, p=0.04), although decreased time to antibiotics was not associated with mortality. Patients who received no fluids more often had previously identified right ventricular systolic dysfunction (62.5% v. 28.6%, p=0.136).
CONCLUSION: Patients with PAH and sepsis have high mortality and receive different treatments than controls, with more reliance on vasopressors and less on fluid resuscitation. PAH patients who received less fluids had higher mortality and those who received no fluids had a longer time to receiving antibiotics, indicating a potential delay in recognizing sepsis. Timely recognition of sepsis and dynamic decision-making around fluid resuscitation remains critical in this high-risk population.
Diagnostic performance of a new algorithm combining simple, non invasive and inexpensive tests for predicting the presence of liver severe fibrosis and cirrhosis in patients with chronic hepatitis b
Authors: Nana Jean , Bosson Jean Luc , Skaare Kristina , Vermorel Céline , Leroy Vincent , Asselah Tarik , Adler Michael , Zarski Jean-Pierre 
Published: April 2024

Abstract
Background
Various non-invasive methods for scoring fibrosis have been developed to overcome the limitations of liver biopsy. These technics have been not fully validated for the assessment of liver fibrosis in chronic hepatitis B. The objective of this study was to evaluate the usefulness of new combining simple, non-invasive and inexpensive tests in terms of predicting liver severe fibrosis and cirrhosis in patients with chronic hepatitis B.
Methods
There is a prospective cross-sectional study conducted on 408 consecutive patients from 3 centers who benefited from a liver biopsy for chronic hepatitis B. Using our cohort, we derived a decision tree, with a cost matrix penalizing type II error, predicting patients in stages F0-F1, F2 or F3-F4. The final decision contains nine leafs using the following variables: prothrombin time, platelets, ALT, GGT and age.
Results
408 patients in training set were used to create a “decision tree algorithm”. Our “decision three algorithm” classified patients in F0-F1, F2 or F3-F4. Considering F0-F1 and F2 as negative test result, specificity was 97.6% and negative predictive value was 88.3%.
Conclusion
A new algorithm combining simple, non-invasive and inexpensive test has a better diagnostic value than usual scores in predicting fibrosis in patients with chronic hepatitis B.
Study Design and Rationale of the ECMC-GART Phase 3 Clinical Study: Early-Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions
Authors: ren kang , Wang Wenhui , Liu Xiaoliang , Sun Shuai , Hu Ke , Zhang Fuquan , Qiu Jie , Yang Bo , Hou Xiaorong 
Published: April 2024

Abstract
Background: Endometrial cancer (EC) represents a prevalent malignancy amongst women on a global scale, with adjuvant therapy strategy remaining inconsistent and controversial. Identifying subtypes integrated with molecular characteristics improves the understanding of cancer biology and consequently helps physicians make personalized therapeutic decision-making. Presented herewith is a study protocol detailing a phase III trial poised to integrate molecular profiling with traditional parameters for the stratification of early-stage EC. The ECMC-GART aims to compare the survival outcomes of integrated molecular classification with the conventional stratification system to provide evidence for further decision-making.
Methods: The ECMC-GART trial is a randomized, national multicenter, Phase III, open-labeled, non-inferiority clinical study (Clinical trial registration: NCT05524389). The hypothesis is that adjuvant radiotherapy decision for early-stage endometrial cancer, which is based on molecular classification, can achieve de-escalation of adjuvant treatment without reducing local tumor control and survival, potentially further reducing radiotherapy-related toxicity and improving quality of life, compared to conventional risk stratification. The enrolled early-staged EC patients (FIGO stage I-II) will be randomized 2:1 into the experimental arm (molecular-clinicopathological classification-based treatment) and the control arm (conventional risk stratification-based treatment). The primary endpoint is the 3-year local recurrence rate. The secondary outcomes include failure-free survival, overall survival, de-escalation rate of treatment, acute and late toxicities, and Health-related cancer-specific quality of life (QLQC-30). The ECMC-GART is intended to enroll 624 EC patients to achieve the purpose of non-inferiority design ultimately.
Discussion: The ECMC-GART will determine whether the molecular classification-based treatment is not inferior to the treatment based 15on previous conventional risk stratification, potentially allowing for de-escalation and individualized treatment recommendations.
Trial registration: ClinicalTrails.gov, NCT05524389. Registered 23 November 2022, https://clinicaltrials.gov/study/NCT05524389
Vortex-like vs. turbulent mixing of a Viscum album preparation affects crystalline structures formed in dried droplets
Authors: Kokornaczyk Maria Olga , Acuña Carlos ,   Alfonso Mier y Terán3, Castelan Mario , Baumgartner Stephan 
Published: April 2024

Abstract

The droplet evaporation method could provide a fairly inexpensive tool for testing the effects of flow in liquids as an alternative to the methods used today.
production of microparticles and microbubbles.
We applied turbulent mixing vs. laminar flow induced by a vortex vs. diffusion based mixing during the production of Viscum album quercus L. 10-3 following the guidelines for manufacturing homeopathic preparations. The so obtained differently mixed variants of the preparation were analyzed by means of the droplet evaporation method. The crystalline structures formed in dried droplets were photographed and analyzed by means of a computer supported image analysis and deep-learning.
Computer supported evaluation and deep-learning reveled that the patterns of turbulent succussed variant are characterized by smaller complexity, whereas those obtained from the vortex mixed sample by greater complexity vs. the diffusion-based mixed control variant.
Enhancing the Security of Botnet Attacks Detection Using Parallel Gradient Descent Optimized Four Layered Network (PGDOFLN)
Authors: Maheswari Uma , Perumal K 
Published: April 2024

Abstract

Internet of Things (IoT) gadget proliferation has resulted in unprecedented connectedness as well as simplicity, but it has raised serious security concerns. Botnet attacks can threaten the security, integrity and accessibility of critical data and services and IoT networks are susceptible to them. To increase the security to identify botnet attacks in IoT networks, this study suggests a model based on a Parallel Gradient Descent Optimized Four Layered Network (PGDOFLN).We gathered the CICIDS2017 dataset from Kaggle, which is used to train and assess the proposed model. Using a robust scalar to handle missing values allows for the normalization of data, the t-distributed stochastic neighbor embedding (t-SNE) technique is utilized for extracting the feature and the LASSO method is used for feature selection. This study on attack detection is based on PGDOFLN and uses a Python program. The simulated results showed that the suggested method outperforms existing methods with an accuracy (0.95), recall (0.95), precision (1.00), and f1 score (0.97). This study supports continuing attempts to protect IoT networks and safeguard private information, vital infrastructure, and sensitive data.