bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Success Probability of Quantum Order Finding
Authors: Ekerå Martin 
Published: March 2024

We prove a lower bound on the probability of Shor’s order-finding algorithm successfully recovering the order
r
in a single run. The bound implies that by performing two limited searches in the classical post-processing part of the algorithm, a high success probability can be guaranteed, for any
r
, without re-running the quantum part or increasing the exponent length compared to Shor. Asymptotically, in the limit as
r
tends to infinity, the probability of successfully recovering
r
in a single run tends to one. Already for moderate
r
, a high success probability exceeding e.g. 1 - 10
-4
can be guaranteed. As corollaries, we prove analogous results for the probability of completely factoring any integer
N
in a single run of the order-finding algorithm.
Nitrosyl-heme and Heme Iron Intake from Processed Meats and Risk of Colorectal Cancer in the EPIC-Spain Cohort
Authors: Rizzolo-Brime Lucía , Lujan-Barroso Leila , Farran-Codina Andreu , Bou Ricard , Lasheras Cristina , Amiano Pilar , Aizpurua Amaia , Sánchez Maria-Jose , Molina-Montes Esther , Guevara Marcela , Moreno-Iribas Conchi , Gasque Alba , Chirlaque-López María Dolores , Colorado-Yohar Sandra M. , Huerta José María , Zamora-Ros Raul , Agudo Antonio , Jakszyn Paula 
Published: March 2024

Abstract

Background:
The International Agency for Research on Cancer classified processed meats (PM) as “carcinogenic” and red meat as “probably carcinogenic” for humans. The possible relationship between colorectal cancer risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds. The aim of this study was to determine the association between nitrosyl-heme and heme iron intake and colorectal cancer risk among participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain study.

Methods:
This prospective study included 38,262 men and women from the EPIC-Spain study. Food consumption was assessed using diet history and food composition tables. Heme iron and nitrosyl-heme intake were determined by estimating the intake of PM items and conducting laboratory analyses. HR estimates were obtained by proportional hazard models, stratified by age at recruitment and study center and adjusted for sex, total energy intake, education, smoking, body mass index, waist size, physical activity, lifetime alcohol, fibre, calcium, and familiar colorectal cancer history.

Results:
During a mean follow-up of 16.7 years, 577 participants were diagnosed with colorectal cancer. We found no overall association between nitrosyl-heme [HRT3vsT1, 0.98; 95% confidence interval (CI), 0.79–1.21] or heme iron intakes (HRT3vsT1, 0.88; 95% CI, 0.70–1.10) with colorectal cancer risk, nor according to tumor subtypes.

Conclusions:
Our study found no evidence supporting a link between nitrosyl-heme or heme iron intake and colorectal cancer risk in Spanish subjects.

Impact:
As research on nitrosyl-heme is preliminary, more heterogeneous studies are necessary to provide more convincing evidence on their role in colorectal cancer carcinogenesis.
Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Authors: Pakola Santeri A. , Peltola Katriina J. , Clubb James H.A. , Jirovec Elise , Haybout Lyna , Kudling Tatiana V. , Alanko Tuomo , Korpisaari Riitta , Juteau Susanna , Jaakkola Marjut , Sormunen Jorma , Kemppainen Jukka , Hemmes Annabrita , Pellinen Teijo , van der Heijden Mirte , Quixabeira Dafne C.A. , Kistler Claudia , Sorsa Suvi , Havunen Riikka , Santos Joao M. , Cervera-Carrascon Victor , Hemminki Akseli 
Published: March 2024

Abstract

Purpose:
TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus armed with TNFa and IL2, designed to induce T-cell infiltration and cytotoxicity in solid tumors.

Patients and Methods:
TUNIMO (NCT04695327) was a single-arm, multicenter phase I dose-escalation trial designed to assess the safety of TILT-123 in advanced solid cancers refractory to standard therapy. Patients received intravenous and intratumoral TILT-123. The primary endpoint was safety by adverse events (AE), laboratory values, vital signs, and electrocardiograms. Secondary endpoints included tumor response, pharmacokinetics, and predictive biomarkers.

Results:
Twenty patients were enrolled, with a median age of 58 years. Most prevalent cancer types included sarcomas (35%), melanomas (15%) and ovarian cancers (15%). No dose-limiting toxicities were observed. The most frequent treatment-related AEs included fever (16.7%), chills (13.0%), and fatigue (9.3%). Ten patients were evaluable for response on day 78 with RECIST 1.1, iRECIST or PET-based evaluation. The disease control rate by PET was 6/10 (60% of evaluable patients) and 2/10 by RECIST 1.1 and iRECIST(20%of evaluable patients). Tumor size reductions occurred in both injected and non-injected lesions. TILT-123 was detected in injected and non-injected tumors, and virus was observed in blood after intravenous and intratumoral injections. Treatment resulted in reduction of lymphocytes in blood, with concurrent lymphocyte increases in tumors, findings compatible with trafficking.

Conclusions:
TILT-123 was safe and able to produce antitumor effects in local and distant lesions in heavily pre-treated patients. Good tolerability of TILT-123 facilitates combination studies, several of which are ongoing (NCT04217473, NCT05271318, NCT05222932, and NCT06125197).
See related commentary by Silva-Pilipich and Smerdou, p. 3649
Impact of Off-Hour Admission on In-Hospital Outcomes for Patients With Stroke Receiving Reperfusion Therapy in China
Authors: Liu Zeyu , Yang Kaixuan , Gu Hongqiu , Wei Minping , Feng Xianjing , Yu Fang , Du Yang , Li Zixiao , Xia Jian 
Published: March 2024

BACKGROUND:
The structure and staffing of hospitals greatly impact patient outcomes, with frequent changes occurring during nights and weekends. This retrospective cohort study assessed the impact of admission timing on in-hospital management and outcomes for patients with stroke receiving reperfusion therapy in China using data from a nationwide registry.

METHODS:
Data from patients receiving reperfusion therapy were extracted from the Chinese Stroke Center Alliance. Hospital admission time was categorized according to day/evening versus night and weekday versus weekend. Primary outcomes were in-hospital death or discharge against medical advice, hemorrhage transformation, early neurological deterioration, and major adverse cardiovascular events. Logistic regression was performed to compare in-hospital management performance and outcomes based on admission time categories.

RESULTS:

Overall, 42 381 patients received recombinant tissue-type plasminogen activator (r-tPA) therapy, and 5224 underwent endovascular treatment (EVT). Patients admitted during nighttime had a higher probability of receiving r-tPA therapy within 4.5 hours from onset or undergoing EVT within 6 hours from onset compared with those admitted during day/evening hours (adjusted odds ratio, 1.04 [95% CI, 1.01–1.08];
P
=0.021; adjusted odds ratio, 1.72 [95% CI, 1.59–1.86];
P
<0.001, respectively). However, no significant difference was observed between weekend and weekday admissions for either treatment. No notable differences were noted between weekends and weekdays or nighttime and daytime periods in door-to-needle time for r-tPA or door-to-puncture time for EVT initiation. Furthermore, weekend or nighttime admission did not have a significant effect on the primary outcomes of r-tPA therapy or EVT. Nevertheless, in patients undergoing EVT, a higher incidence of pneumonia was observed among those admitted at night compared with those admitted during day/evening hours (adjusted odds ratio, 1.22 [95% CI, 1.05–1.42];
P
=0.011).

CONCLUSIONS:
Patients admitted at nighttime were more likely to receive r-tPA therapy or EVT within the time window recommended in the guidelines. However, patients receiving EVT admitted at night had an increased risk of pneumonia.
Drifting to the Periphery of the Ancient Greek World: on Images, Visions, and Dreams
Authors: Baracchi Claudia 
Published: March 2024

Abstract
The essay articulates a rhapsodic reflection on the place of images, their surfacing, and the invisible that sustains them. By way of introduction, it focuses on (1) the initial scenes of Pasolini’s Medea (1969). Following this spellbinding sequence, it addresses (2) the abiding philosophical attraction to the phenomenon of dreams and visions. This will lead to (3) the story of a momentous flight from the Eastern Mediterranean to the Western coast of Italy, sometime during the VI century BCE. One of the outcomes of this event was the founding of Velia, Elea in Attic Greek. These meanderings take us to the periphery of the region “we” call “the West.” More precisely, they point to the periphery of a certain received way of thinking and may contribute to unsettle it. For what begins to emerge from this rhapsody is an unusual profile of the most celebrated pre-classical thinker: Parmenides.
Lost in Place: Nearing Homelessness as Boundless Emptiness of Mind
Authors: Schroeder Brian 
Published: March 2024

Abstract
This essay brings together the perspectives of phenomenology and East Asian philosophies through an engagement with Dōgen, Heidegger, Nishida, and Nishitani to address the concept of place in relation to the concept and feeling of homelessness. With respect to the notion of dwelling and finding one’s place in the world and with oneself, the experience of being and feeling lost psychologically will be considered as a way (dao) toward overcoming nihilism and as an opening to attaining an awakened mind.
Carbon Farming and the Commission Proposal for a Regulation on a Certification Framework for Carbon Removals: a Legal Perspective
Authors: Cavallin Elisa 
Published: March 2024

Abstract
Carbon farming is a term associated with land-based practices, agricultural practices that aim at reducing emissions and sequestering carbon. These are, for example, agroforestry practices and practices that result in the maintenance and enhancement of soil organic carbon through the exploitation of the carbon cycle and the sequestration potential of soils.
Given the evident links with climate change mitigation, the subject matter of carbon and carbon removals has seen important developments in the European Union (EU) in the past few years. This has culminated in the adoption of a Commission Communication on sustainable carbon cycles and a Commission Proposal for a Regulation on a certification framework for carbon removals.
This contribution is meant to address the content and the potentially problematic aspects of the Commission Proposal from a legal perspective.
Safe and Accurate Laparoscopic Total Gastrectomy for Remnant Gastric Cancer With Severe Adhesions Using Indocyanine Green Fluorescence Imaging: Guidance in Detection of the Accurate Dissection Layer to Avoid Organ Injury
Authors: Yamazaki Kimiyasu , Mochizuki Kiyotaka , Date Hiromi , Watanabe Ryohei , Aoki Takeshi 
Published: March 2024

Laparoscopic total gastrectomy (LTG) for remnant gastric cancer (RGC) requires advanced techniques due to severe postoperative adhesions and anatomic changes. We performed LTG in 2 patients with RGC using intraoperative indocyanine green (ICG) fluorescence imaging. Both cases previously underwent distal gastrectomy with Billroth-I reconstruction for gastric cancer and were subsequently diagnosed with early-stage gastric cancer of the remnant stomach. Indocyanine green (2.5 mg/body) was administered intravenously during surgery. The liver and common bile duct were clearly visualized during surgery using near-infrared fluorescence laparoscopy, and the adhesions between the hepatobiliary organs and remnant stomach were safely dissected. Laparoscopic total gastrectomy was successfully performed without complications, and the postoperative course was uneventful in both cases. Intraoperative real-time ICG fluorescence imaging allows clear visualization of the liver and common bile duct and can be useful in LTG for RGC with severe adhesions.
Comparison of Surgical Techniques for the Treatment of Congenital Nasal Pyriform Aperture Stenosis: A Systematic Review
Authors: Rosi-Schumacher Mattie , DiNardo Lauren A. , Reese Alyssa D. , Gupta Soumya , Nagy Ryan E. , Chakraborty Saptarshi , Carr Michele M. 
Published: March 2024

Introduction: Congenital nasal pyriform aperture stenosis (CNPAS) is a rare condition that results in neonatal respiratory difficulty. The purpose of this systematic review was to compare surgical outcomes of drilling versus dilation techniques in the treatment of CNPAS. Methods: Pubmed, Embase, and Cochrane Clinical Trials databases were searched for terms “congenital nasal pyriform aperture stenosis” or “pyriform aperture stenosis” from 2010 to 2021. Twenty-five studies were included that evaluated pediatric patients treated surgically for CNPAS with available outcomes data including complications, revisions, and length of stay. Results: A total of 51 patients with CNPAS were pooled from included studies. The median age was 29 days, 56.9% were female, and 54.9% were born full-term. The median pyriform aperture width before surgery was 5.00 mm (IQR = 4.10, 6.45). Forty (78.4%) patients underwent sublabial drilling, while 6 had a dilation procedure performed with hegar cervical dilators, 2 had a balloon dilation, and 3 were dilated with either an acrylic device, endotracheal tube, or bougie. There were no post-operative complications for 76.5% of patients, while a second surgery was required in 9 (17.6%) patients. The median length of stay was 11 days (IQR = 4, 26). No statistically significant difference was observed between sublabial drilling and surgical dilation techniques with respect to complications, need for revision surgery, or length of stay. Conclusion: Current literature is insufficient to determine if drilling or dilation is more effective in the treatment of CNPAS.
Virtual Reality Adaptive Training for Personalized Stress Inoculation
Authors: Finseth Tor , Dorneich Michael C. , Keren Nir , Franke Warren D. , Vardeman Stephen 
Published: March 2024

Objective To evaluate a personalized adaptive training program designed for stress prevention using graduated stress exposure. Background Astronauts in the high-risk space mission environment are prone to performance-impairing stress responses, making preemptive stress inoculation essential for their training. Methods This work developed an adaptive virtual reality-based system that adjusts environmental stressors based on real-time stress indicators to optimize training stress levels. Sixty-five healthy subjects underwent task training in one of three groups: skill-only (no stressors), fixed-graduated (prescheduled stressor changes), and adaptive. Psychological (subjective stress, task engagement, distress, worry, anxiety, and workload) and physiological (heart rate, heart rate variability, blood pressure, and electrodermal activity) responses were measured. Results The adaptive condition showed a significant decrease in heart rate and a decreasing trend in heart rate variability ratio, with no changes in the other training conditions. Distress showed a decreasing trend for the graduated and adaptive conditions. Task engagement showed a significant increase for adaptive and a significant decrease for the graduated condition. All training conditions showed a significant decrease in worry and anxiety and a significant increase in the other heart rate variability metrics. Conclusion Although all training conditions mitigated some stress, the preponderance of trial effects for the adaptive condition supports that it is more successful at decreasing stress. Application The integration of real-time personalized stress exposure within a VR-based training program not only prepares individuals for high-stress situations by preemptively mitigating stress but also customizes stressor levels to the crew member’s current state, potentially enhancing resilience to future stressors.
Hydrogen treatment reduces electroencephalographic activity and neuronal death in rats with refractory status epilepticus by inhibiting membrane NR2B phosphorylation and oxidative stress
Authors: Jia Ruihua , Zhu Gemin , Zhao Rui , Li Tian , Jiang Wen , Cui Xiaoli 
Published: March 2024

Objective To investigate the effects of hydrogen therapy on epileptic seizures in rats with refractory status epilepticus and the underlying mechanisms. Methods Status epilepticus was induced using pilocarpine. The effects of hydrogen treatment on epilepsy severity in model rats were then monitored using Racine scores and electroencephalography (EEG), followed by western blot of plasma membrane N-methyl-D-aspartate receptor subtype 2B (NR2B) and phosphorylated NR2B expression. We also generated a cellular epilepsy model using Mg2+-free medium and used polymerase chain reaction to investigate the neuroprotective effects of hydrogen. Results There were no significant differences in Racine scores between the hydrogen and control groups. EEG amplitudes were lower in the hydrogen treatment group than in the control group. In epilepsy model rats, hippocampal cell membrane NR2B expression and phosphorylation increased gradually over time. Although hippocampal cell membrane NR2B expression was not significantly different between the two groups, NR2B phosphorylation levels were significantly lower in the hydrogen group. Hydrogen treatment also increased superoxide dismutase, mitochondrial (SOD2) expression. Conclusions Hydrogen treatment reduced EEG amplitudes and NR2B phosphorylation; it also decreased neuronal death by reducing oxidative stress. Hydrogen may thus be a potential treatment for refractory status epilepticus by inhibiting membrane NR2B phosphorylation and oxidative stress.
The Everted Acetabular Labrum: Outcomes of Surgical Management
Authors: Girardi Nicholas G. , Lee Jessica H. , Genuario James W. , Vogel Laura A. , Kraeutler Matthew J. , Keeter Carson , Mei-Dan Omer 
Published: March 2024

Background: An everted acetabular labrum (EL) is a pathologic variant in which the labrum is flipped to the capsular side of the acetabular rim. An iatrogenic EL is a known complication of a poorly executed labral repair, and a recent study described the native acetabular EL. Purpose: To analyze surgical outcomes after advancement or reconstruction of an EL in a native hip. Study Design: Cohort study; Level of evidence, 3. Methods: This was a multicenter retrospective review of prospectively collected data on primary hip arthroscopic surgeries performed between 2013 and 2023. An EL was identified arthroscopically as a labrum–femoral head gap while off traction in the native hip. All patients with EL who were analyzed in this study underwent arthroscopic labral repair and advancement or labral augmentation or reconstruction. Patients with hip dysplasia also underwent periacetabular osteotomy with or without a derotational femoral osteotomy. Patient-reported outcomes (PROs) were assessed using the 12-item International Hip Outcome Tool (iHOT-12) and the Nonarthritic Hip Score. PROs were obtained preoperatively and up to 24 months after surgery. PROs were compared with those of a case-matched control cohort in a 1:2 ratio. Only patients with PROs available at ≥1 year postoperatively were included in the outcome analysis. Results: A total of 111 patients (129 hips) with EL during the study period were identified, with PROs available in 96 hips. The mean age of patients with EL was 30.5 years, and women made up 87% of the cohort. Of the 129 hips with an EL, an isolated diagnosis of an EL was present in 11.6% of hips. Deficient acetabular coverage (lateral center-edge angle <25°) was seen in 40.6% of EL hips. No difference was seen in iHOT-12 scores between EL and control groups at 12- or 24-month follow-up ( P = .18 and .94, respectively). Patients with EL reported a significant improvement of PROs at latest follow-up ( P < .001 for iHOT-12 and Nonarthritic Hip Score). Conclusion: Surgical management of a native EL with restoration of the labral seal on the femoral head and correction of concomitant pathologies resulted in significant clinical improvement, with postoperative outcome scores comparable to those of patients without an EL. These findings provide evidence supporting surgical intervention for a native EL.
Augmented anastomotic ureteral reconstruction using buccal mucosal graft, initial experience
Authors: Reyad Ahmed M , Abd Elhamed Ahmed Mamdouh , Elsherief Ahmed Mahmoud , Abdelhaleem Hassan Ali , Mahmoud Tarek Ahmed 
Published: March 2024

Objective: To assess the augmented anastomotic ureteral reconstruction using buccal mucosal graft based on omental flap for managing ureteral stricture. Subjects and methods: This prospective cohort study was conducted on 13 patients with ureteric strictures of different lengths secondary to Bilhalziasis, iatrogenic (post endoscopy) and post inflammatory etiology in upper and mid ureteral segments were treated with buccal mucosal patch grafts and The graft is fixed to the undersurface or the posterior surface of the omentum before doing graft anastomosis to the ureteral walls as to ensure the process of graft take sticky to the principles of tissue transfer. All patients were subjected to full history taking, clinical examination for assessment of pain, lower or upper urinary track symptoms and laboratory investigation (complete blood count, CRP, liver function test and kidney function test (serum urea and creatinine). Results: The mean operative time was 148.85 min and mean hospital stay was 3 days. Mean blood loss was ranged from 20 to 210 ml and Stent was removed after 8–12 weeks. The mean follow up was 13 months, all patients had a non-obstructive RI value <0.7 with a non-obstructed drainage pattern on the diuretic renogram except one patient who had severe postoperative UTI necessitating nephrostomy tube insertion his drainage curve was plateau. Conclusion: BMG ureteroplasty is a valuable option for a carefully selected patient. The fixation of the graft on the back surface of the omentum allows for better anatomical reconstruction without any twisting to the omental pedicle.
Force transmission and height adjustment stability of the new height adjustable long pillow ballastless track
Authors: He Zhenxing , Luo Cheng , Wang Shuzhen , Yun Jianfeng , Feng Quanbao 
Published: March 2024

To address the settlement issue in high-speed railway foundations, the present study introduces a novel ballastless track system called NHABT (New height-adjustable ballastless track). This paper outlines the structural characteristics of the track and provides a detailed explanation of the methodology employed for height adjustment. To account for the unique properties of the NHABT structure, this study establishes finite element and vehicle-track coupling dynamics models. Firstly, under wheel load conditions, the study investigates the stress distribution of the NHABT structure and analyzes the influence of track bed length, thickness, and height adjustment on the force transfer characteristics of the NHABT structure. Secondly, the impact of height adjustment on the quality of vehicle operation and the stability of the NHABT structure is examined. The results indicate that adjusting the NHABT structure within a range of 20 to 200 mm is achievable by changing the side support pad or sleeper. The maximum stress occurs in the folded corner area on both sides of the sleeper groove. The force transfer characteristics of the NHABT structure are not affected by the length of the track bed, but its thickness significantly influences the stress in the folding corner area of the sleeper groove. The vehicle running quality and the stability of the NHABT structure after the adjustment are maintained at the same level as before the adjustment.