bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of an impedance-based method to monitor the insertion of the electrode array during cochlear implantation
Authors: Gottfried Timo M. , Galeazzi Pablo , Föger Aline , Dejaco Daniel , Tröger Andrea , Fischer Natalie , Innerhofer Veronika , Di Trapani Francesco , Weiss Nora , Seebacher Josef , Dierker Angelika , Schmutzhard Joachim 
Published: April 2024

Abstract
Purpose
Cochlear implantation is a prevalent remedy for severe-to-profound hearing loss. Optimising outcomes and hearing preservation, and minimising insertion trauma, require precise electrode placement. Objective monitoring during the insertion process can provide valuable insights and enhance surgical precision. This study assesses the feasibility and performance of an impedance-based method for monitoring electrode insertion, compared to the surgeon’s feedback.

Methods
The study utilised the Insertion Monitoring Tool (IMT) research software, allowing for real-time measurement of impedance and evoked compound action potential (eCAP) during electrode insertion in 20 patient implantations. This enabled an impedance-based method to continuously assess the status of each electrode during the insertion process. The feasibility and performance was evaluated and compared to the surgeon’s feedback approach. eCAP measurements focused merely on feasibility without searching specific responses.

Results
The IMT demonstrated feasibility in measuring real-time impedances and eCAP during the insertion of the electrode array. The impedance-based method exhibited potential for accurately monitoring the insertion depth with a high success rate. However, further development is needed to improve the number of usable contacts.

Conclusions
Objective monitoring with the impedance-based method shows promise as a valuable tool to enhance the precision of cochlear implant electrode insertion respecting insertion distance estimation. The IMT research software proved feasible in recording real-time impedances and eCAP during electrode insertion. While this impedance-based method exhibits high success rates, further improvements are required to optimise the number of usable contacts. This study highlights the potential of objective monitoring techniques to enhance cochlear implantation outcomes.
The extracellular matrix protein fibronectin promotes metanephric kidney development
Authors: Skoczynski Kathrin , Kraus Andre , Daniel Christoph , Büttner-Herold Maike , Amann Kerstin , Schiffer Mario , Hermann Kristina , Herrnberger-Eimer Leonie , Tamm Ernst R. , Buchholz Bjoern 
Published: April 2024

AbstractComplex interactions of the branching ureteric bud (UB) and surrounding mesenchymal cells during metanephric kidney development determine the final number of nephrons. Impaired nephron endowment predisposes to arterial hypertension and chronic kidney disease. In the kidney, extracellular matrix (ECM) proteins are usually regarded as acellular scaffolds or as the common histological end-point of chronic kidney diseases. Since only little is known about their physiological role in kidney development, we aimed for analyzing the expression and role of fibronectin. In mouse, fibronectin was expressed during all stages of kidney development with significant changes over time. At embryonic day (E) 12.5 and E13.5, fibronectin lined the UB epithelium, which became less pronounced at E16.5 and then switched to a glomerular expression in the postnatal and adult kidneys. Similar results were obtained in human kidneys. Deletion of fibronectin at E13.5 in cultured metanephric mouse kidneys resulted in reduced kidney sizes and impaired glomerulogenesis following reduced cell proliferation and branching of the UB epithelium. Fibronectin colocalized with alpha 8 integrin and fibronectin loss caused a reduction in alpha 8 integrin expression, release of glial-derived neurotrophic factor and expression of Wnt11, both of which are promoters of UB branching. In conclusion, the ECM protein fibronectin acts as a regulator of kidney development and is a determinant of the final nephron number.
Rice physical defenses and their role against insect herbivores
Authors: Balakrishnan Devi , Bateman Nick , Kariyat Rupesh R. 
Published: April 2024

Abstract

Main conclusion

Understanding surface defenses, a relatively unexplored area in rice can provide valuable insight into constitutive and induced defenses against herbivores.

Abstract
Plants have evolved a multi-layered defense system against the wide range of pests that constantly attack them. Physical defenses comprised of trichomes, wax, silica, callose, and lignin, and are considered as the first line of defense against herbivory that can directly affect herbivores by restricting or deterring them. Most studies on physical defenses against insect herbivores have been focused on dicots compared to monocots, although monocots include one of the most important crops, rice, which half of the global population is dependent on as their staple food. In rice, Silica is an important element stimulating plant growth, although Silica has also been found to impart resistance against herbivores. However, other physical defenses in rice including wax, trichomes, callose, and lignin are less explored. A detailed exploration of the morphological structures and functional consequences of physical defense structures in rice can assist in incorporating these resistance traits in plant breeding and genetic improvement programs, and thereby potentially reduce the use of chemicals in the field. This mini review addresses these points with a closer look at current literature and prospects on rice physical defenses.
N-myc downstream–regulated gene 1 can promote vasculogenic mimicry and angiogenesis in urothelial carcinoma
Authors: Louis Ereny Kamal , Abdelkawi Islam F. , Refaiy Abeer , Ahmed Asmaa M. 
Published: April 2024

AbstractUrothelial carcinoma (UC) of the bladder is a common cause of cancer-related death worldwide. Vasculogenic mimicry (VM) is a process by which the malignant cells can generate vascular-like structures formed of periodic acid–Schiff (PAS) positive/CD31 negative extracellular matrix independent of angiogenesis and thus promotes tumor progression. N-myc downstream–regulated gene 1 (NDRG1) is a protein that can modulate tumor angiogenesis; however, its role in regulating tumor angiogenesis and VM formation has not been previously investigated in UC. This study aims to evaluate the role of intra-tumor microvessel density (MVD) (as a surrogate measure of angiogenesis), VM, and NDRG1 in UC and their correlation with different clinicopathologic features, then assess the correlation between them in UC. Sixty specimens of UC of the bladder were included. PAS-CD31 immunohistochemical double staining method was used to evaluate the intra-tumor MVD and VM. Immunohistochemical expression of NDRG1 was also examined. VM and NDRG1 expression were detected in 41.7% and 83.3% of UC specimens respectively. The mean of intra-tumor MVD, VM area, and NDRG1 was significantly higher in tumors with higher grade, lymphovascular invasion, and higher T stage. NDRG1 expression was positively correlated with MVD and VM. We can suggest that MVD, VM, and NDRG1 may serve as poor prognostic markers for UC. The positive correlation between NDRG1 and both MVD and VM may provide the first evidence that NDRG1 can induce tumor angiogenesis and VM in UC which may offer a novel pathway for further therapeutic strategies.
An initiative to implement a triage and referral system to make exercise and rehabilitation referrals standard of care in oncology
Authors: Schmitz Kathryn H. , Chongaway Andrew , Saeed Anwaar , Fontana Toni , Wood Kelley , Gibson Susan , Trilk Jennifer , Adsul Prajakta , Baker Stephen 
Published: April 2024

Abstract
Background
Clinical guidelines suggest that patients should be referred to exercise while undergoing cancer treatment. Oncology clinicians report being supportive of exercise referrals but not having the time to make referrals. Toward the goal of making exercise referrals standard of care, we implemented and evaluated a novel clinical workflow.

Methods
For this QI project, a rehabilitation navigator was inserted in chemotherapy infusion clinics. Patients were offered a validated electronic triage survey. Exercise or rehabilitation recommendations were communicated to patients during a brief counseling visit by the rehabilitation navigator. The implementation approach was guided by the EPIS framework. Acceptability and feasibility were assessed.

Results
Initial meetings with nursing and cancer center leadership ensured buy-in (exploration). The education of medical assistants contributed to the adoption of the triage process (preparation). Audit and feedback ensured leadership was aware of medical assistants’ performance (implementation). 100% of medical assistants participated in implementing the triage tool. A total of 587 patients visited the infusion clinics during the 6-month period when this QI project was conducted. Of these, 501 (85.3%) were offered the triage survey and 391 (78%) completed the survey (acceptability). A total of 176 (45%) of triaged patients accepted a referral to exercise or rehabilitation interventions (feasibility).

Conclusions
Implementation of a validated triage tool by medical assistants and brief counseling by a rehabilitation navigator resulted in 45% of infusion patients accepting a referral to exercise or rehabilitation. The triage process showed promise for making exercise referrals standard of care for patients undergoing cancer treatment.
Electrochemical determination of fenitrothion pesticide based on ultrathin manganese oxide nanowires/molybdenum titanium carbide MXene ionic nanocomposite and molecularly imprinting polymer
Authors: Yola Bahar Bankoğlu , Kotan Gül , Akyıldırım Onur , Atar Necip , Yola Mehmet Lütfi 
Published: April 2024

Abstract A novel molecularly imprinted electrochemical sensor is presented based on one-dimensional ultrathin manganese oxide nanowires/two-dimensional molybdenum titanium carbide MXene (MnO2NWs@Mo2TiC2 MXene) for fenitrothion (FEN) determination. After the synthesis of MnO2NWs@Mo2TiC2 MXene ionic nanocomposite was successfully completed with a facile hydrothermal and the pillaring methods, a new type molecular imprinted electrochemical sensor based on MnO2NWs@Mo2TiC2 MXene was constructed with cyclic voltammetry (CV) polymerization including pyrrole monomer and FEN target molecule. After the characterization studies including spectroscopic, electrochemical and microscopic methods, the analytical applications of the prepared sensor were performed. A linearity of 1.0×10−9–2.0×10−8 mol L−1 was obtained and the values of the quantification limit (LOQ) and the detection limit (LOD) were 1.0×10−9 mol L−1 and 3.0×10−10 mol L−1, respectively. The studies of selectivity, stability and reproducibility of the constructed sensor based on MnO2NWs@Mo2TiC2 nanocomposite and molecularly imprinting polymer (MIP) were carried out in detail. Finally, the developed sensor was applied to white flour samples with the values close to 100%.
Graphical Abstract
Disturbance Level Mediates the Differential Resistance of Tropical Dry Forest Soil and Vegetation Attributes to High-Intensity Hurricanes
Authors: Montiel-González Cristina , Bravo-Monzón Ángel E. , Flores-Puerto José Israel , Valadez-Cortés Fabiola , Azcoytia-Escalona Luz Elena , García-Oliva Felipe , Arena-Ortiz María Leticia , Alvarez-Añorve Mariana Yolotl , Avila-Cabadilla Luis Daniel 
Published: April 2024

AbstractHurricanes are extreme climatic events frequently affecting tropical regions such as the tropical dry forests (TDFs) in Mexico, where its frequency/intensity is expected to increase toward the year 2100. To answer how resistant is a Mexican tropical dry forest to a high-intensity hurricane, and if its degree of resistance was mediated by its conservation degree, we evaluated the effect of a category 4 hurricane over the tree community, soil nutrients, and soil enzymatic activity in two contrasting TDF ecosystems: Old-Growth Forest (OGF) and Secondary Forest (SF). In general, vegetation richness and diversity showed very high resistance one year after the hurricane, but several structural attributes did not, especially in the OGF where the tree mortality related to vegetation structure and spatial distribution of individuals was higher. Then, in the short term, SF vegetation appeared to be more resistant, whereas the OGF, with more biomass to lose, appeared to be more vulnerable. Conversely, most soil attributes showed low resistance in both stages, but especially in SF which could face more severe nutrient limitations. The response of TDF to high-intensity hurricanes, in terms of above- and belowground processes, was in part dependent on its disturbance level. Moreover, an increase in the intensity/frequency of hurricanes could lead this TDF toward a high nutrient limitation (especially by phosphorus) for the plants and consequently toward a loss of soil functioning, especially in the SF. This eventually could produce a severe degradation in fundamental attributes and functions of the ecosystem.
Entity linking for English and other languages: a survey
Authors: Guellil Imane , Garcia-Dominguez Antonio , Lewis Peter R. , Hussain Shakeel , Smith Geoffrey 
Published: April 2024

AbstractExtracting named entities text forms the basis for many crucial tasks such as information retrieval and extraction, machine translation, opinion mining, sentiment analysis and question answering. This paper presents a survey of the research literature on named entity linking, including named entity recognition and disambiguation. We present 200 works by focusing on 43 papers (5 surveys and 38 research works). We also describe and classify 56 resources, including 25 tools and 31 corpora. We focus on the most recent papers, where more than 95% of the described research works are after 2015. To show the efficiency of our construction methodology and the importance of this state of the art, we compare it to other surveys presented in the research literature, which were based on different criteria (such as the domain, novelty and presented models and resources). We also present a set of open issues (including the dominance of the English language in the proposed studies and the frequent use of NER rather than the end-to-end systems proposing NED and EL) related to entity linking based on the research questions that this survey aims to answer.
Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA
Authors: Gong Yizi , Shen Chanjuan , Meng Ting , Lin Wei , Hu Xueling , Tang Rong , Xiong Qi , Ooi Joshua D. , Eggenhuizen Peter J. , Chen Jinbiao , Zhou Ya-Ou , Luo Hui , Xu Jia , Liu Ning , Xiao Ping , Xiao Xiangcheng , Zhong Yong 
Published: April 2024

AbstractAnti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) patients with dual positivity for proteinase 3-ANCA (PR3-ANCA) and myeloperoxidase-ANCA (MPO-ANCA) are uncommon. We aimed to investigate these idiopathic double-positive AAV patients’ clinical features, histological characteristics, and prognosis. We reviewed all the electronic medical records of patients diagnosed with AAV to obtain clinical data and renal histological information from January 2010 to December 2020 in a large center in China. Patients were assigned to the MPO-AAV group or PR3-AAV group or idiopathic double-positive AAV group by ANCA specificity. We explored features of idiopathic double-positive AAV. Of the 340 patients who fulfilled the study inclusion criteria, 159 (46.76%) were female, with a mean age of 58.41 years at the time of AAV diagnosis. Similar to MPO-AAV, idiopathic double-positive AAV patients were older and had more severe anemia, lower Birmingham Vasculitis Activity Score (BVAS) and C-reactive protein (CRP) levels, less ear, nose, and throat (ENT) involvement, higher initial serum creatinine and a lower estimated glomerular filtration rate (eGFR) when compared with PR3-AAV (P < 0.05). The proportion of normal glomeruli of idiopathic double-positive AAV was the lowest among the three groups (P < 0.05). The idiopathic double-positive AAV patients had the worst remission rate (58.8%) among the three groups (P < 0.05). The relapse rate of double-positive AAV (40.0%) was comparable with PR3-AAV (44.8%) (P > 0.05). Although there was a trend toward a higher relapse rate of idiopathic double-positive AAV (40.0%) compared with MPO-AAV (23.5%), this did not reach statistical significance (P > 0.05). The proportion of patients who progressed to ESRD was 47.1% and 44.4% in the idiopathic double-positive AAV group and MPO-AAV group respectively, without statistical significance. Long-term patient survival also varied among the three groups (P < 0.05). Idiopathic double-positive AAV is a rare clinical entity with hybrid features of MPO-AAV and PR3-AAV. MPO-AAV is the “dominant” phenotype in idiopathic double-positive AAV.
Fusing Diverse Decision Rules in 3D-Radiomics for Assisting Diagnosis of Lung Adenocarcinoma
Authors: Ren He , Wang Qiubo , Xiao Zhengguang , Mo Runwei , Guo Jiachen , Hide Gareth Richard , Tu Mengting , Zeng Yanan , Ling Chen , Li Ping 
Published: April 2024

AbstractThis study aimed to develop an interpretable diagnostic model for subtyping of pulmonary adenocarcinoma, including minimally invasive adenocarcinoma (MIA), adenocarcinoma in situ (AIS), and invasive adenocarcinoma (IAC), by integrating 3D-radiomic features and clinical data. Data from multiple hospitals were collected, and 10 key features were selected from 1600 3D radiomic signatures and 11 radiological features. Diverse decision rules were extracted using ensemble learning methods (gradient boosting, random forest, and AdaBoost), fused, ranked, and selected via RuleFit and SHAP to construct a rule-based diagnostic model. The model’s performance was evaluated using AUC, precision, accuracy, recall, and F1-score and compared with other models. The rule-based diagnostic model exhibited excellent performance in the training, testing, and validation cohorts, with AUC values of 0.9621, 0.9529, and 0.8953, respectively. This model outperformed counterparts relying solely on selected features and previous research models. Specifically, the AUC values for the previous research models in the three cohorts were 0.851, 0.893, and 0.836. It is noteworthy that individual models employing GBDT, random forest, and AdaBoost demonstrated AUC values of 0.9391, 0.8681, and 0.9449 in the training cohort, 0.9093, 0.8722, and 0.9363 in the testing cohort, and 0.8440, 0.8640, and 0.8750 in the validation cohort, respectively. These results highlight the superiority of the rule-based diagnostic model in the assessment of lung adenocarcinoma subtypes, while also providing insights into the performance of individual models. Integrating diverse decision rules enhanced the accuracy and interpretability of the diagnostic model for lung adenocarcinoma subtypes. This approach bridges the gap between complex predictive models and clinical utility, offering valuable support to healthcare professionals and patients.
A whole ecosystem approach to pear psyllid (Cacopsylla pyri) management in a changing climate
Authors: Reeves Laura A. , Garratt Michael P. D. , Fountain Michelle T. , Senapathi Deepa 
Published: April 2024

AbstractWhole ecosystem-based approaches are becoming increasingly common in pest management within agricultural systems. These strategies consider all trophic levels and abiotic processes within an ecosystem, including interactions between different factors. This review outlines a whole ecosystem approach to the integrated pest management of pear psyllid (Cacopsylla pyri Linnaeus) within pear (Pyrus communis L.) orchards, focusing on potential disruptions as a result of climate change. Pear psyllid is estimated to cost the UK pear industry £5 million per annum and has a significant economic impact on pear production globally. Pesticide resistance is well documented in psyllids, leading to many growers to rely on biological control using natural enemies during the summer months. In addition, multiple insecticides commonly used in pear psyllid control have been withdrawn from the UK and Europe, emphasising the need for alternative control methods. There is growing concern that climate change could alter trophic interactions and phenological events within agroecosystems. For example, warmer temperatures could lead to earlier pear flowering and pest emergence, as well as faster insect development rates and altered activity levels. If climate change impacts pear psyllid differently to natural enemies, then trophic mismatches could occur, impacting pest populations. This review aims to evaluate current strategies used in C. pyri management, discuss trophic interactions within this agroecosystem and highlight potential changes in the top-down and bottom-up control of C. pyri as a result of climate change. This review provides a recommended approach to pear psyllid management, identifies evidence gaps and outlines areas of future research.
Climate change will likely facilitate invasion of Asian orchid Eulophia graminea into new areas
Authors: Kolanowska Marta , Rewicz Agnieszka , Ackerman James D. 
Published: April 2024

AbstractClimate change plays an increasing role in the global biodiversity crisis. Alteration in local climatic conditions not only can negatively affect native biodiversity but also can accelerate the introduction and spread of invasive species. In this study the ecological niche modelling approach was used to evaluate possible changes in the distribution of suitable niches of invasive orchid Eulophia graminea within its native (Asia) and non-native geographical range (America, Australia). We mapped the current potential range of this species and analysed three various projections of future climate (for 2100) each with four different climate change scenarios (SSPs). Calculated niche overlap indexes indicated low similarity of niches occupied by native and invasive populations of E. graminea and Australian populations seem to be the most unique, while American and Asian groups share partially similar niches. The occurrence of the American population of E. graminea was correlated especially with the temperature seasonality, while the Asian and Australian populations with annual precipitation and precipitation of the wettest quarter. As indicated in our analyses within Asia and America, E. graminea does not occupy all climatically suitable niches. On the other hand, in Australia the species studied already occupies all appropriate niche space. Climate change will likely be favorable for species studied to expand its range if the biotic components of its niche space (e.g., mycorrhizal fungi) will respond similarly. The most significant range expansion is predicted to occur in Australia which is interesting considering the marginally suitable habitats that E. graminea currently occupies.