bluuebunny/crossref_metadata_2025_split huggingface dataset:
The stability and change of wellbeing across the lifespan: a longitudinal twin-sibling study
Authors: de Vries Lianne P. , Pelt Dirk H. M. , Bartels Meike 
Published: March 2024

AbstractBackgroundWellbeing is relatively stable over the life span. However, individuals differ in this stability and change. One explanation for these differences could be the influence of different genetic or environmental factors on wellbeing over time.MethodsTo investigate causes of stability and change of wellbeing across the lifespan, we used cohort-sequential data on wellbeing from twins and their siblings of the Netherlands Twin Register (NTR) (total N = 46.885, 56% females). We organized wellbeing data in multiple age groups, from childhood (age 5), to adolescence, up to old age (age 61+). Applying a longitudinal genetic simplex model, we investigated the phenotypic stability of wellbeing and continuity and change in genetic and environmental influences.ResultsWellbeing peaked in childhood, decreased during adolescence, and stabilized during adulthood. In childhood and adolescence, around 40% of the individual differences was explained by genetic effects. The heritability decreased toward old adulthood (35–24%) and the contribution of unique environmental effects increased to 76%. Environmental innovation was found at every age, whereas genetic innovation was only observed during adolescence (10–18 years). In childhood and adulthood, the absence of genetic innovation indicates a stable underlying set of genes influencing wellbeing during these life phases.ConclusionThese findings provide insights into the stability and change of wellbeing and the genetic and environmental influences across the lifespan. Genetic effects were mostly stable, except in adolescence, whereas the environmental innovation at every age suggests that changing environmental factors are a source of changes in individual differences in wellbeing over time.
Redes de afiliaciones socioculturales en El Tintal, Petén, Guatemala: Una perspectiva desde la cerámica
Authors: Patiño-Contreras Alejandro , Alvarado Najarro Silvia , Acuña Mary Jane 
Published: March 2024

ResumenA partir de los conceptos de modo y sistema cerámico, analizamos el rango de variación estilística en las cerámicas de El Tintal, Guatemala, como indicadores de conexiones sociales, económicas y políticas a nivel regional. Nuestro estudio muestra que la población de El Tintal participó en sistemas cerámicos con una distribución geográfica extensa durante los períodos preclásico medio y tardío, clásico temprano y clásico tardío. Durante los períodos preclásico terminal y clásico terminal, sin embargo, El Tintal participó en sistemas de afiliación con cobertura espacial limitada, aunque entre estos circulan conjuntos de cerámicas particulares a larga distancia. Con base en los resultados del estudio proponemos aquí algunas explicaciones a estos patrones en términos de dinámicas de interacción sociocultural y económicas.
The embedded Wh- in situ clause: French tout court? Les spasmes musculaires incontrôlés, je sais pas c’est quoi (France Info 20/10/21)
Authors: Ledegen Gudrun 
Published: March 2024

AbstractAlthough not studied by the generative approach (Shlonsky 2017), the embedded Wh- in situ clause nevertheless belongs to the French language spoken in a large amount of areas, and, we believe, to “français tout court” (Blanche-Benveniste & Jeanjean 1987): until now, it has mainly been studied in Quebec (Lefebvre & Maisonneuve 1982; Blondeau & Ledegen 2021) and in Reunion Island (Ledegen 2007a, 2007b, 2007c, 2016; Ledegen & Martin 2020), but it has recently been massively attested in the Multicultural Paris French project in the suburbs of Paris (Gardner-Chloros & Secova 2018) and Strasbourg (Marchessou 2018). These new data could be read as a language contact, as a recent linguistic change, or as a long-established “popular” structure (Guiraud 1966), different analytical hypotheses that will be detailed in this study. These recent data also argue in favour of the methodology of ecological corpora, obtained within the framework of a strong acquaintanceship and located at the pole of communicative proximity (Koch & Oesterreicher 2001). The examination of various existing corpora will reveal the structural functioning of the structure and contrast the corpora following the modes of interaction, the oral or written medium, as well as on the chronological axis.
Healthy lifestyle promotion via digital self-help for mental health patients in primary care: a pilot study including an embedded randomized recruitment trial
Authors: Kolaas Karoline , Axelsson Erland , Hedman-Lagerlöf Erik , Berman Anne H. 
Published: March 2024

Abstract

Aim:
This study piloted a digital self-help intervention facilitating healthy lifestyle for patients with mental health problems in primary care.

Background:
Patients with mental health problems show more unhealthy lifestyle behaviors than the general population and prior research indicates that healthy lifestyle behaviors can improve mental health.

Methods:
This pilot study assessed use of a self-help digital intervention for healthy lifestyle promotion and included an embedded randomized recruitment trial, where all patients were randomized to digital self-help plus treatment as usual (TAU) or to TAU only. Patients seeking help for mental health problems were recruited from two primary care clinics in Stockholm, Sweden, and offered participation in a healthy lifestyle promotion study via digital self-help. Outcome measures included use-related assessment of inclusion and follow-up rates at both clinics, participant characteristics, and intervention adherence. Secondary outcomes included depression (the Patient Health Questionnaire-9) and anxiety (the GAD-7) up to 10 weeks, and changes in alcohol and tobacco use, physical activity, and diet.

Results:
The study included 152 patients. The recruitment rate, initially low, increased after involving the clinicians more and maintaining more frequent contact with the patients. The 10-week missing data rate was 33/152 (22%). Participants were 70% (106/152) women, with a mean age of 42 years (SD = 14); fewer than half (38%, n = 58/152) had one or more high-risk unhealthy behaviors at inclusion. Psychiatric symptoms were moderate at baseline and declined in both groups after 10 weeks (d = 0.57–0.75). No between-group effects over time occurred on depression (b = 0.3 [95% CI −1.6, 2.2]; d = 0.06), anxiety (b = −0.7 [−2.5, 1.2]; d = 0.13), or lifestyle behaviors (b = 0.01 [−0.3, 0,3]; d = −0.01).

Conclusions:
Recruitment routines seemed to be decisive for reaching as many patients as possible. The relatively low rate of unhealthy lifestyle behaviors and small effect sizes suggests that the intervention may only suit patients at risk.

Trial registration:
ClinicalTrials.gov NCT03691116 (01/10/2018), focusing on the embedded trial. Retrospectively registered for the first clinic and prospectively for the second clinic.
Dying at home: What is needed? Findings from a nationwide retrospective cross-sectional online survey of bereaved people in Germany
Authors: Kasdorf Alina , Voltz Raymond , Strupp Julia 
Published: March 2024

AbstractObjectivesAccording to the “Last Year of Life in Cologne” study, 68% of patients with a serious and terminal illness wanted to die at home, but 42% died in hospital. Only 1 in 5 died at home. Most people want to spend their last days and hours at home, but the reality is that this is not always possible. Recommendations are needed on how best to support families to enable people to die at home – if this is their preferred place of death. Our aim was to identify the factors that make it possible for people to die at home and to analyze factors of dying at home.MethodsGermany-wide quantitative cross-sectional online survey of bereaved adult relatives.ResultsThe needs of 320 relatives of patients who wished to die at home were explored. Of these, 198 patients died at home and 122 did not. In the last 3 months of life, caregivers needed support in managing out-of-hours care (p < 0.001), financing (p = 0.012), preparing and organizing home care (both p < 0.001), communicating with the patient and medical staff (p = 0.012 and p = 0.009, respectively), and pain management (p < 0.001). Relatives whose next of kin did not die at home had higher needs, suggesting that these factors are key to home care of the dying.Significance of resultsThe process of dying at home begins long before the actual dying phase. To minimize caregiver burden and improve symptom management, advanced home care plans are needed, with ongoing reassessment of family preferences and abilities.
Intercession and Anamnesis in the Eucharist
Authors: Browning Ron 
Published: March 2024

Abstract
Examining intercession and anamnesis in the Anglican Eucharist first, a theology of the world in which its brokenness as embraced by the compassion of Christ, is seen to undergird intercession, whereby a ‘natural’ link is found with the anamnesis. Turning to the historical background of relationship between these two topics – in the Early Church, noted are two particular forms as recorded by Justin Martyr and Cyril of Jerusalem; in the English Reformation, it is seen that intercession was maintained as a part of the canon (and therefore had some connection with the anamnesis), and then, the modern period displays a departure in Anglican provinces from the Reformation order with only a loose principle, or none, maintained in its position between Word and Sacrament. The retrieval of Christ overcoming the powers of evil in his redemptive work, as recorded in Hippolytus’ liturgical form, has made its way into the modern liturgy, providing implications for the connection between anamnesis and intercession. The liturgiology of the Orthodox Church strengthens the theme. Present concerns regarding the Anglican practice of Eucharistic intercession are raised and improvements are suggested. It is concluded that, theologically, intercession and anamnesis hold an intimate connection in the Eucharist.
Dependence of Tropical Cyclone Weakening Rate in Response to an Imposed Moderate Environmental Vertical Wind Shear on the Warm‐Core Strength and Height of the Initial Vortex
Authors: Gao Qi , Wang Yuqing 
Published: March 2024

AbstractThis study investigated the dependence of the early tropical cyclone (TC) weakening rate in response to an imposed moderate environmental vertical wind shear (VWS) on the warm‐core strength and height of the TC vortex using idealized numerical simulations. Results show that the weakening of the warm core by upper‐level ventilation is the primary factor leading to the early TC weakening in response to an imposed environmental VWS. The upper‐level ventilation is dominated by eddy radial advection of the warm‐core air. The TC weakening rate is roughly proportional to the warm‐core strength and height of the initial TC vortex. The boundary‐layer ventilation shows no relationship with the early weakening rate of the TC in response to an imposed moderate VWS. The findings suggest that some previous diverse results regarding the TC weakening in environmental VWS could be partly due to the different warm‐core strengths and heights of the initial TC vortex.
Organic Carbon Sources in Surface Sediments on the Northern South China Sea
Authors: Lin Baozhi , Liu Zhifei , Eglinton Timothy I. , Wiesner Martin G. , Blattmann Thomas M. , Haghipour Negar 
Published: March 2024

AbstractThe burial of organic carbon (OC) in marine sediments regulates CO2 content in the atmosphere. However, the OC sources and their effect on the OC preservation in sediments of the continental marginal sea remain elusive. Here, we survey the abundance, stable carbon and radiocarbon isotopes of OC, as well as mineral surface area and grain size in surface sediments from the shelf to the abyssal plain of the South China Sea. We found that the marine OC comprises the 63 ± 9% and 78 ± 14% of sedimentary OC off South China and Luzon, respectively. The petrogenic OC contributing to sedimentary OC in these sites is generally higher than that of soil OC (22 ± 10% vs. 12 ± 6%). The sedimentary OC off Taiwan is predominantly derived from petrogenic OC, accounting for 57 ± 10%, with remaining consisting of marine OC (36 ± 10%) and soil OC (6 ± 1%). High soil OC contents are found in fine sediments on the inner shelf off South China, and high petrogenic OC contents occur in fine sediments off Taiwan. Marine OC contents are high in fine sediments on the middle shelf and upper slope off South China, but low in coarse sediments on the outer shelf and upper slope, and fine sediments on the lower slope and abyssal plain. The OC sources, mineral surface area, and oxygen exposure time of OC together control the preservation of OC in sediments with their relative importance differing on varying depositional settings of this sea.
Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses
Authors: Chi Hang , Zhao Suo-Qun , Chen Ru-Yi , Suo Xing-Xing , Zhang Rong-Rong , Yang Wen-Hui , Zhou Dong-Sheng , Fang Min , Ying Bo , Deng Yong-Qiang , Qin Cheng-Feng 
Published: March 2024

AbstractThe Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing processes. mRNA-encoded antibodies have emerged as a powerful and universal platform for rapid antibody production. Herein, by using the established lipid nanoparticle (LNP)-encapsulated mRNA platform, we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against orthopoxviruses. In vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing antibodies. More importantly, mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus (VACV) lethal challenge mouse model, and a unique mRNA antibody cocktail, Mix2a, exhibited superior in vivo protection by targeting both intracellular mature virus (IMV)-form and extracellular enveloped virus (EEV)-form viruses. In summary, our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform, highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as other emerging viruses.
Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells
Authors: Liu Wuming , Ren Yifan , Wang Tao , Wang Mengzhou , Xu Yujia , Zhang Jia , Bi Jianbin , Wu Zheng , Zhang Yuanyuan , Wu Rongqian 
Published: March 2024

AbstractAcute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis are involved in the pathogenic mechanisms of AP. CIRP is a stress-response protein and a damage-associated molecular pattern (DAMP) molecule. In our previous studies, we discovered that excessive CIRP can directly damage pancreatic acinar cells. Nonetheless, the precise involvement of CIRP in AP is still unexplored. The primary aim of this study was to examine the potential involvement of CIRP in the development of pyroptosis and mitochondrial dysfunction in AP. To study this, an L-arginine-induced AP mouse model was used. Our results showed that Caspase-1-mediated pyroptosis and mitochondria-derived reactive oxygen species (ROS) were crucial factors in the occurrence of tissue damage and inflammation in AP. A substantial increase in the CIRP serum levels was observed in AP mice. Blocking CIRP by either CIRP gene knockout or systemic administration of C23, a competing inhibitor of CIRP, reduced ROS accumulation and pyroptosis in AP mice. These effects were associated with attenuated pancreatic injury and inflammation. In addition, CIRP-triggered mitochondrial dysfunction, autophagy impairment, and pyroptosis in pancreatic acinar cells were prevented by TAK242, an inhibitor of CIRP receptor TLR4. In conclusion, CIRP can induce mitochondrial dysfunction and pyroptosis in pancreatic acinar cells, and blocking CIRP may be a valuable approach to treating patients with AP.
Optimizing the corrosion performance of rust layers: role of Al and Mn in lightweight weathering steel
Authors: Tang Yihao , Guo Yuxing , Ji Pengfei , Li Bo , Xia Chaoqun , Zhang Shuzhi , Zhang Junsong , Zhang Xinyu , Liu Riping 
Published: March 2024

AbstractIn this study, the corrosion behavior of AlMn lightweight weathering steel (LWS) in the simulated marine atmosphere was investigated by means of the dry/wet corrosion cycle test. The results showed that Al was present as FeAl2O4 and enriched in the inner layer, which significantly optimizes the rust layer in terms of compactness, elemental distribution, phase constitution, and electrochemical properties. The Mn oxides promoted the formation of FeAl2O4 and enhanced the anti–rupture ability of the LWS’s rust layer.
Association between T1w/T2w ratio in white matter and cognitive function in Alzheimer’s disease
Authors: Lee Sae-Nal , Woo Sung-Ho , Lee Eun Ja , Kim Kwang Ki , Kim Hang-Rai 
Published: March 2024

AbstractLoss of myelin in the brain may lead to cognitive decline in Alzheimer's disease (AD). The ratio of T1 weighted/T2 weighted (T1w/T2w) on magnetic resonance imaging has been used as a proxy for myelin content in the brain. Using this approach, we investigated the correlation between the white matter (WM) T1w/T2w ratio and both cognitive scores and disease progression in AD. A total of 93 participants who were cognitively unimpaired or diagnosed with mild cognitive impairment or AD dementia were recruited between March 2021 and November 2022. All participants were assessed using neuropsychological tests, and a subset of the participants was assessed every 1 year to monitor disease progression. We observed significant positive associations between the WM T1w/T2w ratio and executive function within the fornix, sagittal stratum, anterior internal capsule, and body of the corpus callosum (False discovery rate [FDR]-corrected P-value < 0.05). There was a marginal interaction between the WM T1w/T2w ratio of the left anterior internal capsule and the longitudinal change in sum of boxes of the Clinical Dementia Rating Scale (FDR-corrected P-value = 0.05). The present study demonstrated that the WM T1w/T2w ratio was associated with executive function and disease progression, suggesting that it may be a novel neuroimaging marker for AD.
A new unit distribution: properties, estimation, and regression analysis
Authors: Karakaya Kadir , Rajitha C. S. , Sağlam Şule , Tashkandy Yusra A. , Bakr M. E. , Muse Abdisalam Hassan , Kumar Anoop , Hussam Eslam , Gemeay Ahmed M. 
Published: March 2024

AbstractThis research commences a unit statistical model named power new power function distribution, exhibiting a thorough analysis of its complementary properties. We investigate the advantages of the new model, and some fundamental distributional properties are derived. The study aims to improve insight and application by presenting quantitative and qualitative perceptions. To estimate the three unknown parameters of the model, we carefully examine various methods: the maximum likelihood, least squares, weighted least squares, Anderson–Darling, and Cramér-von Mises. Through a Monte Carlo simulation experiment, we quantitatively evaluate the effectiveness of these estimation methods, extending a robust evaluation framework. A unique part of this research lies in developing a novel regressive analysis based on the proposed distribution. The application of this analysis reveals new viewpoints and improves the benefit of the model in practical situations. As the emphasis of the study is primarily on practical applications, the viability of the proposed model is assessed through the analysis of real datasets sourced from diverse fields.
Acellular porcine Achilles tendon patch encapsulating tendon-derived stem cells for rotator cuff repair in a rabbit model
Authors: Wen Huawei , Fang Yushun 
Published: March 2024

AbstractCurrently, the predominant method for repairing rotator cuff involves surgical suture techniques, but the failure rate remains notably high. Failure of the rotator cuff insertion to provide adequate biomechanics during early healing is considered a major cause of failure. Addressing this problem, biological augmentation emerges as a promising strategy for enhancing the biomechanical properties during early stages. Tendon-derived stem cells (TDSCs), which facilitate the differentiation of repair-supportive cells, hold the potential to improve the efficacy of patch application. The study aims to assess the behavior of TDSCs in acellular porcine Achilles tendon (APAT) patches and to explore the capacity of the APAT patch encapsulating TDSCs in promoting both tendon-to-bone healing and biomechanical enhancements in a rabbit rotator cuff repair model. Transmission electron microscopy (TEM) analyses validated the complete cellular clearance of native cells from APAT patches, with uniform distribution of TDSCs. Immunofluorescence staining confirmed successful TDSCs attachment, while population doubling time (PDT) underscored increased TDSCs proliferation on APAT patches. Quantitative polymerase chain reaction (qPCR) demonstrated upregulation of tenocyte and osteocyte related genes in TDSCS cultured within the patches. In the subsequent in vivo experiment, fifty-four rabbits were used to create rotator cuff injury models and randomly assigned to a control group, an APAT patch group, and an APAT patch with TDSCs group. Histological analysis showed that the APAT patch with TDSCs group had significantly enhanced tendon-to-bone healing and a distinctly organized tendon-fibrocartilage-bone structure, as compared to the APAT patch group. In addition, the biomechanical properties of the APAT patch with TDSCs group were significantly improved. In conclusion, APAT patches promote TDSC proliferation and stimulate tenogenic and osteogenic differentiation. APAT patches encapsulating TDSCs have shown considerable potential in promoting tendon-to-bone healing of rotator cuff injuries, indicating that their use in rotator cuff repair surgery is clinically meaningful.