bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen modifications predictive of lymph node metastasis in dogs with carcinoma in mixed tumours
Authors: Garcia Ana Paula Vargas , Taborda Daiana Yively Osorio , Reis Luana Aparecida , de Paula Ana Maria , Cassali Geovanni Dantas 
Published: March 2024

IntroductionMixed tumours in the canine mammary gland are the most common histological type in routine diagnosis. In general, these neoplasms have a favourable prognosis that does not evolve into metastatic disease. However, some cases develop into lymph node metastases and are associated with worse patient survival rates.MethodsHere is a retrospective study of 46 samples of primary mixed tumours of the canine mammary gland: 15 cases of benign mixed tumours (BMT), 16 cases of carcinoma in mixed tumours without lymph node metastasis (CMT), and 15 cases of carcinomas in mixed tumours with lymph node metastasis (CMTM). In addition, we selected 23 cases of normal mammary glands (NMT) for comparison. The samples were collected from biopsies performed during nodulectomy, simple mastectomy, regional mastectomy, or unilateral/bilateral radical mastectomy. We used multiphoton microscopy, second harmonic generation, and two-photon excited fluorescence, to evaluate the characteristics of collagen fibres and cellular components in biopsies stained with haematoxylin and eosin. We performed Ki67, ER, PR, and HER-2 immunostaining to define the immunophenotype and COX-2. We showed that carcinomas that evolved into metastatic disease (CMTM) present shorter and wavier collagen fibres as compared to CMT.Results and discussionWhen compared to NMT and BMT the carcinomas present a smaller area of fibre coverage, a larger area of cellular coverage, and a larger number of individual fibres. Furthermore, we observed a correlation between the strong expression of COX-2 and a high rate of cell proliferation in carcinomas with a smaller area covered by cell fibres and a larger number of individual fibres. These findings highlight the fundamental role of collagen during tumour progression, especially in invasion and metastatic dissemination.
Electric Field Characteristics of Rotating Permanent Magnet Stimulation
Authors: Robins Pei L. , Makaroff Sergey N. , Dib Michael , Lisanby Sarah H. , Deng Zhi-De 
Published: March 2024

Neurostimulation devices that use rotating permanent magnets are being explored for their potential therapeutic benefits in patients with psychiatric and neurological disorders. This study aims to characterize the electric field (E-field) for ten configurations of rotating magnets using finite element analysis and phantom measurements. Various configurations were modeled, including single or multiple magnets, and bipolar or multipolar magnets, rotated at 10, 13.3, and 350 revolutions per second (rps). E-field strengths were also measured using a hollow sphere (r=9.2 cm) filled with a 0.9% sodium chloride solution and with a dipole probe. The E-field spatial distribution is determined by the magnets’ dimensions, number of poles, direction of the magnetization, and axis of rotation, while the E-field strength is determined by the magnets’ rotational frequency and magnetic field strength. The induced E-field strength on the surface of the head ranged between 0.0092 and 0.52 V/m. In the range of rotational frequencies applied, the induced E-field strengths were approximately an order or two of magnitude lower than those delivered by conventional transcranial magnetic stimulation. The impact of rotational frequency on E-field strength represents a confound in clinical trials that seek to tailor rotational frequency to individual neural oscillations. This factor could explain some of the variability observed in clinical trial outcomes.
Water Supply via Pedicel Reduces Postharvest Pericarp Browning of Litchi (Litchi chinensis) Fruit
Authors: Fang Fang , Liu Bin , Fu Liyu , Tang Haiyao , Li Yanlan , Pang Xuequn , Zhang Zhaoqi 
Published: March 2024

Pericarp browning is the key factor for the extension of shelf life and the maintenance of the commercial value of harvested litchi fruit. Water loss is considered a leading factor of pericarp browning in litchi fruit. In this study, based on the distinct structure of litchi fruit, which is a special type of dry fruit with the aril as the edible part, the effects of water supply via pedicel (WSP) treatment on pericarp browning and the fruit quality of litchi were investigated. Compared with the packaging of the control fruit at 25 °C or 4 °C, the WSP treatment was found to significantly reduce pericarp browning and the decay of litchi fruit. The WSP-treated fruit had a higher L* value, total anthocyanin content, and pericarp water content, and the pericarp was thicker. The WSP treatment significantly suppressed the increase in the electrolyte leakage of the pericarp and maintained higher ascorbic acid (AA) contents in the aril. In addition, the WSP treatment was effective in reducing the activity and gene expression of browning-related genes Laccase (ADE/LAC) and Peroxidase (POD) during the storage period. In conclusion, the WSP treatment could be an effective method to delay pericarp browning and maintain the quality of harvested litchi fruit, and this further supports that litchi fruit has dry fruit characteristics.
Diversity of Genetic and Vegetative Compatibility Group of Colletotrichum coccodes Isolates from Chile Using Amplified Fragment Length Polymorphism Markers
Authors: Alananbeh Kholoud M. , Rivera Viviana , Bravo Ivette Acuña , Secor Gary , Gudmestad Neil C. 
Published: March 2024

Colletotrichum coccodes (Wallr.) Hughes is an asexual fungus with five vegetative compatibility groups. It was postulated that C. coccodes was isolated at the center of origin of potato at one time, and due to the movement of potato around the globe, the fungus was established on each continent but became bottlenecked and genetically unable to form stable heterokaryons via vegetative compatibility grouping (VCG) studies. The objectives of this study were (i) to determine if the VCGs around the world are related to the VCGs in Chile, (ii) to determine the diversity of C. coccodes populations in Chile, and (iii) to find any evidence for a cryptic sexual life cycle for this fungus. Worldwide C. coccodes populations have been found to be genetically correlated and belong to one or more C. coccodes-identified VCGs. The most distributed VCG in Chile was VCG2, which is the most common VCG in North America. We hypothesize that one or more VCGs had spread from Chile to the rest of the world. Precautions and further studies should be investigated by using other molecular markers and gene sequencing.
Workshop Instrumen Kelayakan Sistem Informasi untuk Bisnis UMKM
Authors: Najwa Nina fadilah , Trisnadoli Anggy , Muslim Istianah 
Published: March 2024

Persaingan bisnis antar Usaha Mikro, Kecil dan Menengah (UMKM) semakin ketat seiring dengan perkembangan Teknologi Informasi. Dalam perencanaan bisnis UMKM perlu dilakukan analisis kelayakan bisnis untuk mengetahui bisnis tersebut diproyeksikan akan mendapatkan keuntungan atau bahkan kerugian. Dalam pembuatan bisnis tentunya ada investasi yang harus dikeluarkan oleh pengusaha. Analisis kelayakan penting untuk megantisipasi kendala dan menimalkan resiko kegagalan pengembangan bisnis. Salah satu metode yang dapat membantu pengusaha bisnis dalam menganalisis kelayakan bisnisnya adalah menggunakan Metode TELOS yang terdiri dari lima faktor kelayakan, yaitu Teknis (Technical Factor), Ekonomi (Economic Factor), Hukum (Legal Factor), Operasional (Operational Factor), dan Jadwal (Schedule Factor). Pada kegiatan Pengabdian kepada Masyarakat ini dilakukan pelatihan penggunaan sistem informasi kelayakan bisnis kepada pelaku UMKM. Sistem informasi kelayakan bisnis ini telah dikembangkan dan dapat diakses secara bebas oleh UMKM. Adapun mitra kegiatan Pk M ini adalah Caraka Corp yang bergerak di bidang konsultasi dan pengembangan bisnis UMKM. Caraka Corp membantu tim PkM dalam menyediakan peserta UMKM yang akan dilatih. Peserta pelatihan kelayakan sistem informasi untuk bisnis UMKM telah terlaksana sesuai dengan jadwal yang telah direncanakan
PENGARUH SOCIAL MEDIA MARKETING TIKTOK TERHADAP MINAT BELI KONSUMEN PADA PRODUK SCARLETT WHITENING
Authors: Bessie Juita L. D. , Wie Windi Efrinda 
Published: March 2024

This study aims to determine and analyze: (1) The effect of Entertainment, Interaction, Trendiness, Customization, and e-WOM has a partial effect on Consumer Buying Interest in Scarlett Whitening products. (2) The effect of Entertainment, Interaction, Trendiness, Customization, and e-WOM simultaneously affects Consumer Buying Interest in Scarlett Whitening products. The number of samples is 50 respondents, and the sampling technique used was purposive. The data is collected using Google form questionnaires. The analysis techniques used are quantitative descriptive, Multiple Linear Regression Analysis, and hypothesis testing through t-test and F-test, using the SPSS 22 application. The results of the descriptive analysis show that overall respondents gave a high category perception assessment of Entertainment, Interaction, Trendiness, and Customization and a very high category perception assessment of e-WOM. The results of the t-test and F-test show that partially and simultaneously, Entertainment, Interaction, Trendiness, Customization, and e-WOM have a significant effect on Consumer Buying Interest. Based on the value of Adjusted R2 the contribution of the variables Entertainment, Interaction, Trendiness, Customization, and e-WOM toward Consumer Buying Interest are 97.2%. While 2.8% was influenced by other variables outside the focus of this study.
Keywords: Entertainment; Interaction; Trendiness; Customization; e-WOM; Consumer Buying Interest
THE EFFECT OF NON-PERFORMING LOANS ON BANK LIQUIDITY DURING THE COVID-19 PANDEMIC
Authors: Christanto Felicia , Susanto Grace Febiola 
Published: March 2024

This study aims to determine the impact of the Covid-19 pandemic on banking liquidity in Indonesia. This study used data samples from 25 banks in Indonesia listed on the stock exchange from 2016 Q1 – 2021 Q4. Data collection for 6 years was chosen to determine banking trends before and during the pandemic. The research method used was regression panel data using the independent variable non-performing loan ratio and the dependent variable loan-to-deposit ratio to measure bank liquidity. The period before the COVID-19 pandemic (2016 Q1 - 2020 Q1) and after the COVID-19 pandemic (2020 Q2 - 2021 Q4) used dummy variables. The result was that the ratio of non-performing loans affected bank liquidity during the COVID-19 pandemic. This is due to the disruption of bank cash inflow because many debtors have difficulty fulfilling obligations to the bank.
Keywords: Banking Liquidity; Credit Risk; Non-Performing Loans
MARKETING MIX EFFECT TOWARDS CONSUMER SATISFACTION AND ITS IMPACT ON LOYALTY:
Authors: Ratnawati Ema , Mubarokah Mubarokah , Wijayati Prasmita Dian 
Published: March 2024

The purpose of this study is to analyze the effect of 4P’s marketing mix (product, price, place, promotion) on consumer satisfaction and analyze the effect of satisfaction on consumer loyalty. This research involves quantitative data collection by distributing questionnaires to a purposively selected sample of 100 consumers of Jeruk Pecel Tulen soy sauce in Surabaya City. The analysis method used is the PLS-SEM (Partial Least Square – Structural Equation Modeling). The results showed that the 4P’s marketing mix variables have a positive relationship with consumer satisfaction, but not all of them have a significant effect. The variables of product and price have a positive and significant effect on satisfaction, while the variables of place and promotion do not have a significant effect on the satisfaction of consumers. Furthermore, satisfaction has a positive and significant effect on consumer loyalty of Jeruk Pecel Tulen soy sauce. The limitation of this study is that other variables can measure customer satisfaction and loyalty besides the marketing mix. However, conducting this research can provide insights for future research in helping companies build stronger relationships with consumers, increase consumer loyalty, and ultimately drive business growth.
Keywords: Marketing Mix; Consumer Satisfaction; Consumer Loyalty
URGENSI EVENT IMAGE DAN TOURISM EXPERIENCE DALAM MENCIPTAKAN REVISIT INTENTION PADA DESA WISATA KABUPATEN SUMENEP
Authors: Yulistira Silvia Rahma , A. S. Fathor 
Published: March 2024

This research was motivated by a decrease in the number of visitors to the Kedatim Mangrove Tourism, Sumenep Regency. This research aims to determine the influence of event image and tourism experience on the intention to visit again, both directly and through the intervening variable of tourism satisfaction at Kedatim Mangrove Tourism. The sampling technique used was purposive sampling with a total sample of 100 visitors. The data collection technique was carried out by distributing questionnaires to respondents. The data analysis technique used is Partial Least Square. The research results show that event image (X1) does not have a significant effect on intention to revisit. Tourist experience (X2) has a significant effect on the intention to visit again. The image of the event (X1) has a significant effect on tourism satisfaction. Tourist experience (X2) has a significant effect on tourist satisfaction. Tourist satisfaction (Z) does not affect interest in returning to visit. Event image (X1) has no significant effect on the intention to revisit through tourism statistics. Tourist experience (X2) does not have a significant effect on the intention to visit again through tourism satisfaction.
Keywords: Event Image; Tourism Experience; Tourism Statisfaction; Revisit Intention
PENGARUH BIAYA PRODUKSI DAN BIAYA PENJUALAN TERHADAP LABA BERSIH PADA SUBSEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Putra Andri Eko , Oktariansyah Oktariansyah , Rahayu Dita 
Published: March 2024

This study aims to determine the effect of Production Cost and Sales Cost on the Net Profit of companies in the food and beverage sub-sector listed on the Indonesian Stock Exchange. The method in this study is the quantitative method. The population in this study includes 26 companies listed on the Indonesian Stock Exchange. Six companies were selected as the research sample. The data in this study is the secondary data obtained from audited annual reports and reported to the Indonesian Stock Exchange. The data analysis techniques in this study are classical hypothesis tests, i.e. normality test, multicollinearity test, heteroscedasticity test, autocorrelation test, multiple linear regression analysis, hypothesis testing, and coefficient of determination test. The results obtained from this study indicated that Production Costs have no significant influence on the Net Profit, while Sales Costs have a significant effect on the Net Profit, and at the same time, Production Costs and Sales Costs affect profits simultaneously.
Keywords: Production Cost; Sales Cost; Net Profit
DESKRIPSI TINGKAT PENGETAHUAN KESEHATAN REPRODUKSI DAN PERSEPSI KONTROL PERILAKU SEKSUAL REMAJA DI KARANG TARUNA GAJAH MUDA SELOJARI
Authors: Kumalasari Nurya , Sahara Rizki 
Published: March 2024

Latar belakang; Remaja adalah fase yang rentan dengan kenakalan terutama seksualitas. Seksual yang masih dianggap tabu menjadikan kurangnya pengetahuan pada remaja sehingga lebih banyak remaja telah melakukan perilaku seksual sebelum menikah. Tujuan untuk mendeskripsikan tingkat pengetahuan dan kontrol perilaku seksual remaja karang tarunaMetode; Penelitian ini menggunakan rancangan deskriptif dengan pendekatan studi deskriptif. Populasi penelitian ini adalah remaja karang taruna di Selojari dengan jumlah sampel 46. Tehnik pengambilan sampel dengan random sampling yang digunakan yaitu pertanyaan dengan kuesioner dan telah dilakukan uji validitas dan reabilitas terlebih dahulu.Hasil; Remaja berumur 16-18 tahun; jenis kelamin mayoritas perempuan; tingkat pengetahuan kesehatan reproduksi yaitu kategori kurang sebanyak 29,4 %; cukup 58,8 %; baik 11,8 %. Persepsi kontrol perilaku baik sebanyak 51,8% dan buruk 48,2%.Kesimpulan; ; tingkat pengetahuan remaja tentang kesehatan reproduksi sebagian besar memiliki tingkat pengetahuan cukup yaitu 58,8% (27 orang), dan persepsi kontrol perilaku baik 51,8 %. Kata kunci; Pengetahuan, Kesehatan Reproduksi, Kontrol Perilaku, Remaja
PENGARUH PIJAT IBU HAMIL TERHADAP PENURUNAN NYERI PUNGGUNG PADA IBU HAMIL TRIMESTER III DI WILAYAH KERJA PUSKESMAS KAYEN KABUPATEN PATI
Authors: Ni'amah Siti , Sulistiyaningsih Sri Hadi 
Published: March 2024

Latar belakang; Kehamilan trimester III terjadi perubahan fisik dan psikologis. Kondisi tersebut menyebabkan ibu hamil mengalami keluhan yang komplek seperti ketidaknyamanan salah satunya nyeri pada punggung. Salah satu solusi untuk mengatasi ketidak nyamanan tersebut adalah pijat ibu hamil. Penelitian ini bertujuan untuk mengetahui pengaruh pijat hamil terhadap penurunan nyeri punggung pada ibu hamil trimester di wilayah kerja Puskesmas Kayen Kabupaten Pati .Metode: Jenis penelitian menggunakan pra-eksperiment - one group pre post test design . Populasi penelitian sebanyak 30 Ibu hamil Trimester III dengan teknik sampling total sampling. Variable independent pijat pada ibu hamil dan variable dependent penurunan nyeri punggung pada ibu hamil. Instrument penelitian menggunakan SOP, analisa data menggunakan uji statistic t test adalah sebesar 0,819 dengan nilai probabilitas jauh dibawah 0,05.Hasil: penelitian ini menunjukkan sebelum melakukan pijat ibu hamil sejumlah 16 ibu hamil (53,3%) mengalami nyeri ringan setelah melakukan pijat ibu hamil 25 ibu hamil (83,3%) mengalami nyeri ringan dan 5 ibu hamil (16,7%) mengalami nyeri sedang.Kesimpulan: ada pengaruh Pijat ibu hamil terhadap penurunan nyeri punggung ibu hamil Trimester III di Wilayah Kerja Puskesmas Kayen Kabupaten Pati Kata Kunci: Pijat Ibu Hamil, Penurunan Nyeri Punggung.
PENGARUH PARITAS DAN GAYA HIDUP TERHADAP KEJADIAN BBLR PADA IBU DENGAN PRE EKLAMPSIA BERAT
Authors: Sahara Rizki , Wigati Dhiyan Nany 
Published: March 2024

Latar belakang : BBLR merupakan penyebab kematian neonatal tertinggi pada tahun 2022. Salah satu komplikasi dari pre-eklampsia pada ibu adalah lahirnya bayi dengan berat badan rendah dan kelahiran premature, didukung dengan teori menjelaskan bahwa paritas merupakan salah satu faktor yang mempengaruhi kejadian BBLR. Dewasa ini gaya hidup masyarakat mengalami pergeseran dengan banyaknya konsumsi makanan tidak sehat dan kebiasaan lain yang mempengaruhi menurunnya derajat kesehatan terlebih pada ibu hamil.Metode : Desain penelitian merupakan penelitian kuantitatif dengan menggunakan desain kasus dan kontrol (case control) dan pendekatan retrospektif. Menggunakan sampel sebanyak 64 sampel yang dibagi menjadi 32 sampel untuk kelompok kasus dan 32 sampel dalam kelompok control.Hasil : Hasil analisis penelitian ini menunjukkan adanya hubungan yang signifikan antara paritas dan gaya hidup dengan kejadian berat bayi lahir rendah pada ibu dengan Pre-eklampisa berat yang ditandai dengan maing - masing p value 0.002 dan 0.000. paritas mempunyai pengaruh lebih besar terhadap kejadian BBLP pada ibu Pre-eklampsia dibandingakan dengan gaya hidup.Kesimpulan : Paritas dan gaya hidup mempunyai hubungan yang signifikan terhadap kejadian BBLR pada ibu dengan Pre-eklampsia Berat. Paritas mempunyai pengaruh lebih besar terhadap kejadian berat bayi lahir endah pada ibu dengan Pre-eklampsia. Kata kunci : Paritas, Gaya hidup, BBLR, Pre-eklampsia.
ASUHAN KEBIDANAN BALITA SAKIT DIARE AKUT PADA AN. K UMUR 4 TAHUN 6 BULAN DENGAN FOKUS INTERVENSI PEMBERIAN MADU MURNI DI PUSKESMAS TOROH I
Authors: Zulichah Mariza Siti , Sahara Rizki , Himawati Laily 
Published: March 2024

Latar belakang : Pengertian Penyakit Diare endemis diindonesia dan juga merupakan peyakit potensial kejadian luar biasa (KLB) yang sering disertai kematian. Penyakit Diare masih merupakan masalah kesehatan masyarakat indonesia. Berdasarkan kajian dari analisa beberapa survay yang dilakukan pada balita, Diare adalah 1.5 kali pertahun. Kematian balita akibat diare terjadi karena tidak ditolong secara dini dan tidak diberikan pengobatan secara tepat. Secara teoritis diberikan 10% dari penderita diare akan meninggal akibat terjadinya proses dehidrasi berat bila tidak diberikan pengobatan. Tujuan penelitian ini adalah untuk mengetahui apakah pengaruh pemberian madu murni terhadap penurunan frekuensi diare pada balita.Metode : Rancangan penelitian yang peneliti gunakan adalah rancangan penelitian studi kasus. Jenis penelitian studi kasus deskriptif ini menggunakan metode observasi partisipatif. Subjek dalam penelitian ini adalah ibu hamil trimester I hamil 11Rancangan penelitian yang peneliti gunakan adalah rancangan penelitian studi kasus. Jenis penelitian studi kasus deskriptif ini menggunakan metode observasi partisipatif. Subjek dalam penelitian ini adalah balita yang berusia 4 tahum 6 bulan.Hasil : Hasil penelitian menunjukan diagnosa pada An.K dengan pemberian madu murni. Evaluasi pelaksanaan pemberian madu murni pada kasus An.K dengan pemberian madu murni untuk menurunkan frekuensi maupun konsistensi diare pada balita.Kesimpulan : Terjadi penurunan frekuensi mapun konsistensi diare pada balita setelah diberikan pengobatan pemberian madu murni. Kata kunci : Pemberian madu, Frekuensi diare, Anak Balita.
HUBUNGAN TINGKAT STRES DENGAN KEJADIAN HIPERTENSI PADA PASIEN RAWAT INAP DI RUMAH SAKIT MARDI RAHAYU KUDUS
Authors: Pujiastuti Cicilia , Hindriyastuti Sri , Winarsih Biyanti Dwi 
Published: March 2024

Latar belakang; Hipertensi menjadi salah satu penyakit tidak menular yang perlu diwaspadai yang ditandai dengan peningkatan darah diatas normal secara persisten. Hipertensi saat ini semakin meningkat jumlahnya. Tingginya prevalensi hipertensi disebabkan kebiasaan yang tidak sehat. Faktor psikologis seperti stress juga menjadi faktor pemicu peningkatan tekanan darah, terutama pada kelompok dewasa akhir dan lansia. Penelitian ini bertujuan untuk mengetahui hubungan tingkat stres dengan kejadian hipertensi pada pasien rawat inap di RS Mardi Rahayu Kudus.Metode; Jenis penelitian bersifat korelasi dengan desain cross sectional. Populasi penelitian ini adalah penderita hipertensi di rawat inap Rumah Sakit Mardi Rahayu Kudus. Teknik sampling dengan purposive sampling sehingga besar sampel sebanyak 36 responden. Pengumpulan data dengan kuesioner. Analisa data secara statistik dengan uji Chi Square.Hasil; Hasil uji statistik dengan menggunakan chi-squre didapatkan nilai p-value 0,000.Kesimpulan; Terdapat hubungan signifikan antara tingkat stres dengan kejadian hipertensi pada pasien rawat inap di Rumah Sakit Mardi Rahayu Kudus karena nilai p (0.000) < 0.05 pada taraf signifikansi 5%. Kata Kunci : Tingkat Stres, Hipertensi, Pasien Rawat Inap.