bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dried plums (prunes) reduce atherosclerosis lesion area in apolipoprotein E-deficient mice
Authors: Gallaher Cynthia M. , Gallaher Daniel D. 
Published: September 2008

Dried plums are a fruit high in pectin with substantial antioxidant activity. Previous studies in rats and man indicate that dried plums or plum fibre lower liver and plasma cholesterol, respectively. The apoE-deficient mouse, which develops atherosclerotic lesions rapidly when fed cholesterol, was used to determine the ability of dried plums to reduce atherosclerosis. Diets containing 0·15 % cholesterol and either 0 (B+C), 4·75 % (Lo DP) or 9·5 % (Hi DP) dried plum powder were fed for 5 months. An additional group fed the basal diet without cholesterol (B − C) was included as a negative control. Arterial trees were dissected, stained to visualize lesions, and lesion area was quantitated by imaging software. Urinary thiobarbituric acid-reactive substances (TBARS) excretion and serum amyloid P-component (SAP) were measured as indicators of oxidative stress and inflammation, respectively. Final serum cholesterol was significantly increased and serum TAG decreased in the B+C group and dried plum groups relative to the B − C group. Percentage arterial tree atherosclerotic lesion area was significantly lower in the B − C and Lo DP groups compared to the B+C group (P < 0·05), with a trend for a difference between the B+C and Hi DP groups (P = 0·075). SAP concentration was significantly lower in the B − C and Lo DP groups with the Hi DP group trending lower than the B+C group. Urinary TBARS excretion did not differ among the groups. These results suggest that consuming dried plums may help slow the development of atherosclerosis.
Effect of type and timing of oil supplements to sows during pregnancy on the growth performance and endocrine profile of low and normal birth weight offspring
Authors: Laws John , Litten Jennie C. , Laws Alison , Lean Ian J. , Dodds Peter F. , Clarke Lynne 
Published: September 2008

Eighty-eight multiparous sows were used to evaluate whether type and timing of oil supplementation during gestation influences the incidence of low birth weight (LBW). Sows were allocated (eight per treatment) commercial sow pellets (3 kg/d; control diet) or an experimental diet consisting of control diet plus 10 % extra energy in the form of excess pellets, palm oil, olive oil (OO), sunflower oil (SO) or fish oil; experimental diets were fed during either the first half (G1) or second half (G2) of gestation. Growth performance and endocrine profile of LBW ( < 1·09 kg) and normal birth weight (NBW; 1·46–1·64 kg) offspring were compared. Maternal dietary supplementation altered the distribution curve for piglet birth weight. SOG1 sows had a greater proportion of LBW piglets (P < 0·05), whilst it was reduced in the OOG1 group (P < 0·05). Growth rate of LBW piglets was lower compared with their NBW siblings (P < 0·05) when dietary supplementation was offered in G2 but were similar for G1. At birth, LBW offspring of supplemented animals possessed more fat compared with the control group (P < 0·05); LBW offspring of control animals exhibited a more rapid decline in fat free mass/kg prior to weaning. Plasma metabolites and insulin concentrations were influenced by maternal diet and birth weight. In conclusion, maternal dietary supplementation altered the distribution of piglet birth weights and improved the energy status of LBW piglets. Supplementation with MUFA during G1 reduced the incidence of LBW, whereas PUFA had the reverse effect.
Spectrum of nasal disease in an asthma clinic: when is an ENT opinion indicated?
Authors: Stanton A E , McGarry G W , Carter R , Bucknall C E 
Published: September 2008

AbstractAims:To characterise the spectrum of nasal symptomatology and nasendoscopic abnormalities seen in patients attending an asthma clinic, and to relate these symptoms to the likelihood of finding nasendoscopic abnormalities which merit treatment.Methods:Forty-three patients attending a problem asthma clinic were enrolled in an observational study. Cardinal nasal symptoms – obstruction, congestion, hyposmia, rhinorrhoea, sneezing, epistaxis or other symptoms – were graded as none (zero), mild (one), moderate (two) or severe (three), giving a maximum nasal symptom score of 21. Asthma symptoms and lung function were measured. Nasendoscopy was then performed.Results:Obstruction was the most common cardinal nasal symptom (seen in 15 patients), the median nasal symptom score was 5.3 (range zero to 14) and only three patients had no nasal symptoms. There was no correlation between nasal symptom score and severity of asthma symptoms or forced expiratory volume in one second. Twenty-two patients had a normal appearance on ENT examination (median nasal symptom score four). The nasendoscopic abnormalities seen comprised polyps (n = 8; median nasal symptom score five), deviated nasal septum (n = 7; median nasal symptom score four), oedematous mucosa (n = 4; median nasal symptom score seven) and other abnormalities (n = 2). Individual nasal symptoms were poor predictors of individual nasal pathologies, with hyposmia the best individual predictor of any abnormality (positive predictive value 80 per cent). The presence of a combination of symptoms increased the likelihood of any nasendoscopic abnormality, with obstruction, rhinorrhoea and hyposmia together having a positive predictive value of 100 per cent.Conclusions:Nasal symptoms are much more frequent than structural abnormalities in patients attending a problem asthma clinic. The threshold for ENT referral should be lower when the patient complains of a symptom complex including hyposmia. Furthermore, concurrent hyposmia, obstruction and rhinorrhoea should be seen as an indication for ENT referral.
Endoscopic sinus surgery as day-case procedure
Authors: Bajaj Y , Sethi N , Carr S , Knight L C 
Published: September 2008

AbstractObjective:Functional endoscopic sinus surgery is the mainstay of surgical treatment for chronic sinusitis. Day-case surgery has the advantage over in-patient surgery of being cost-effective and resource sparing. The objectives of this study were to assess our results for day-case functional endoscopic sinus surgery.Methods:This was a retrospective case note review of day-case functional endoscopic sinus surgery procedures performed at Leeds General Infirmary from February 2004 to February 2007. We recorded patients' demographic data, operative details, post-operative course and follow-up results.Results:A total of 105 day-case functional endoscopic sinus surgery procedures were included in the study. Patients' ages ranged from 16 to 93 years; 44 (41.9 per cent) were female and 61 (58.1 per cent) were male. Of these patients, 39 (37.1 per cent) had chronic sinusitis and the rest (66; 62.8 per cent) had nasal polyposis and sinusitis. Sixty-one patients (58.1 per cent) underwent surgery on the morning operating list, while the rest (44; 41.9 per cent) underwent surgery in the afternoon. Of the 105 patients, 24 (22.8 per cent) had undergone previous nasal surgery. The majority of patients (90/105; 85.7 per cent) were discharged on the same day as surgery. The only complication recorded in this study was bleeding, noted in seven patients (6.7 per cent). At the follow-up appointment, 90/105 (85.7 per cent) patients were satisfied with their post-operative results.Conclusions:Day-case endoscopic sinus surgery can be performed safely as a day-case procedure. The most important factors for a successful outcome are correct patient selection, in terms of general health and social circumstances, and a dedicated day-case team.
Immunotherapy in head and neck cancer: current practice and future possibilities
Authors: Agada F O , Alhamarneh O , Stafford N D , Greenman J 
Published: September 2008

AbstractThe survival of patients with head and neck squamous cell carcinoma has changed little over the last 30 years. However, with recent advances in the fields of cellular and molecular immunology, there is renewed optimism with regards to the development of novel methods of early diagnosis, prognosis estimation and treatment improvement for patients with head and neck squamous cell carcinoma. Here, we present a critical review of the recent advances in tumour immunology, and of the current efforts to apply new immunotherapeutic techniques in the treatment of head and neck squamous cell carcinoma.
Head and neck tumour immunology: basic concepts and new clinical implications
Authors: Topping K P , Fletcher L M , Agada F O , Alhamarneh O , Stafford N D , Greenman J 
Published: September 2008

AbstractAn understanding of the immune system and its modes of action is fundamental to understanding the causes, natural history, management and treatment of many diseases. As such, a grasp of the principles of immunology is essential for every physician.This paper represents a succinct overview of the immune system, discussing the major components in turn, in respect of structure, function and integrated organisation, in relation to head and neck cancer.
Paediatric aneurysmal bone cysts of the head and neck
Authors: Fennessy B G , Vargas S O , Silvera M V , Ohlms L A , McGill T J , Healy G B , Rahbar R 
Published: September 2008

AbstractObjective:To provide an up to date review of the literature on aneurysmal bone cysts, including their diagnosis, pathology, pathophysiology, radiology and management.Method:Retrospective review of six cases over a 15-year period.Results:Six patients (age range, eight months to 17 years; mean, 9.6 years) presented with an aneurysmal bone cyst in the mandible (n = 3), maxilla (n = 2) or occipital soft tissue (n = 1). Each patient underwent primary excision, with one subsequent recurrence.Conclusion:Aneurysmal bone cysts are benign but locally destructive entities which may occasionally present to otolaryngologists, since they can involve the head and neck region, in particular the mandible.
Staining of nasal mucosa to examine remodelling
Authors: Ahmed S K , Williams J L , Drake-Lee A , Egginton S 
Published: September 2008

AbstractBackground and objective:The process of embedding tissue in paraffin degrades many important molecules involved in respiratory epithelial remodelling. We therefore examined alternative methods.Methods:Inferior turbinate and nasal polyp biopsies were either placed in formalin or immediately snap-frozen in the operating theatre. Novel protocols for staining remodelling markers were compared with current methods.Results:Our method, using a mixture of three lectins, stained a significantly greater proportion of samples, compared with using Ulex europeaus lectin alone (84 vs 62 per cent; p < 0.005). Comparison of different proliferation markers showed that Ki67 was more suitable than proliferating cell nuclear antigen for frozen sections.Conclusions:This study indicates that our robust, repeatable methods for examining whole mounts and for staining capillaries, cell proliferation and nuclei on the same section of nasal mucosa are superior to current methods. The use of fresh tissue that has not been paraffin-embedded would allow a greater suite of epitopes to be examined in the future.
Nasal bacterial carriage in adult epistaxis: is neomycin the answer?
Authors: Walker F D L , Baring D E C 
Published: September 2008

AbstractIntroduction:After treatment of epistaxis, patients are routinely supplied with an intranasal bactericidal cream containing neomycin. Neomycin cream is effective in preventing recurrent paediatric epistaxis. This study aimed to assess whether there is an increased rate of nasal bacterial infections in adult epistaxis patients.Methods:Between October 2004 and April 2005, nasal swabs were taken from adult patients presenting with epistaxis, and from a control group comprising elective ENT patients.Results:There were 23 controls and 26 epistaxis patients. Staphylococcus aureus was grown in 21 per cent and 23 per cent, respectively. There was no significant difference in bacterial carriage rates between the epistaxis and control groups.Conclusions:The epistaxis and control groups demonstrated the same bacterial species and the same proportion of bacterial carriage. Although the majority of bacterial species encountered were sensitive to neomycin, a significant proportion was not. These results do not support the routine use of neomycin in the prevention of recurrent adult epistaxis.
Economic viability of stapes surgery in Germany
Authors: Savvas E , Maurer J 
Published: September 2008

AbstractObjective:The purpose of this study was to determine the economic viability of stapes surgery in Germany. We compared the cost of the operation to the retail value and average cost of a lifelong supply of hearing aids.Study design:Retrospective study.Setting:Tertiary referral centre.Patients:One hundred and sixty-four consecutive cases of primary stapedotomy performed on patients with otosclerosis at our institution served as the representative group for the calculation. The post-operative air–bone gap average at the frequencies 500, 1000, 2000 and 4000 Hz was less than 10 dB for 62 per cent of the patients, and less than 20 dB for 92 per cent of the patients. There was a post-operative sensorineural hearing loss in 1.2 per cent of the patients.Results:Analysis showed that, even for an elderly patient aged 65 years with a life expectancy of 15 years, the cost of a lifelong supply of hearing aids was greater than that of a stapedotomy procedure. Based on our group of patients, the stapedotomy procedure proved to be €800000 K cheaper than treatment with an averagely priced hearing aid. The economic benefit was still present when taking into account possible revision surgery in 5–10 per cent of cases, and also when, in addition to the surgery, a post-operative hearing aid was required, in for example 20 per cent of cases.Conclusion:Stapes surgery is economically beneficial for the individual patient as well as for the general patient cohort, irrespective of age. The stapedotomy procedure also prevents the known disadvantages of conventional hearing aids, thus improving the patient's quality of life.
Early acquisition of gender agreement in the Spanish noun phrase: starting small
Authors: MARISCAL SONIA 
Published: September 2008

ABSTRACTNativist and constructivist accounts differ in their characterization of children's knowledge of grammatical categories. In this paper we present research on the process of acquisition of a particular grammatical system, gender agreement in the Spanish noun phrase, in children under three years of age. The design of the longitudinal study employed presents some variations in relation to classical studies. The aim was to obtain a large corpus of NP data which would allow different types of analysis of the children's productions to be carried out. Intra-individual variability in early NP types was analyzed and measured, and an elicitation task for adjectives was used. Results show that the acquisition of NP and gender agreement is a complex process which advances as the children gradually integrate different pieces of evidence: phonological, distributional and functional. The reduction of variability as the grammatical process advances is a key feature for its explanation.
Developmental differences in the effects of phonological, lexical and semantic variables on word learning by infants
Authors: STORKEL HOLLY L. 
Published: September 2008

ABSTRACTThe influence of phonological (i.e. individual sounds), lexical (i.e. whole-word forms) and semantic (i.e. meaning) characteristics on the words known by infants age 1 ; 4 to 2 ; 6 was examined, using an existing database (Dale & Fenson, 1996). For each noun, word frequency, two phonological (i.e. positional segment average, biphone average), two lexical (i.e. neighborhood density, word length) and four semantic variables (i.e. semantic set size, connectivity, probability resonance, resonance strength) were computed. Regression analyses showed that more infants knew (1) words composed of low-probability sounds and sound pairs, (2) shorter words with high neighborhood density, and (3) words that were semantically related to other words, both in terms of the number and strength of semantic connections. Moreover, the effect of phonological variables was constant across age, whereas the effect of lexical and semantic variables changed across age.
Obligatory grammatical categories and the expression of temporal events*
Authors: WINSKEL HEATHER , LUKSANEEYANAWIN SUDAPORN 
Published: September 2008

ABSTRACTThai has imperfective aspectual morphemes that are not obligatory in usage, whereas English has obligatory grammaticized imperfective aspectual marking on the verb. Furthermore, Thai has verb final deictic-path verbs that form a closed class set. The current study investigated if obligatoriness of these grammatical categories in Thai and English affects the expression of co-occurring temporal events and actions depicted in three different short animations. Ten children aged four years, five years, six years and seven years, and ten adults as a comparison group from each of the two languages participated. English speakers explicitly expressed the ongoingness of the events more than Thai speakers, whereas Thai speakers expressed the entrance and exit of protagonists depicted in the animations significantly more than English speakers. These results support the notion that obligatory grammatical categories shape how Thai and English speakers express temporal events or actions.
A common contrast pooling rule for suppression within and between the eyes
Authors: MEESE TIM S. , CHALLINOR KIRSTEN L. , SUMMERS ROBERT J. 
Published: September 2008

AbstractRecent work has revealed multiple pathways for cross-orientation suppression in cat and human vision. In particular, ipsiocular and interocular pathways appear to assert their influence before binocular summation in human but have different (1) spatial tuning, (2) temporal dependencies, and (3) adaptation after-effects. Here we use mask components that fall outside the excitatory passband of the detecting mechanism to investigate the rules for pooling multiple mask components within these pathways. We measured psychophysical contrast masking functions for vertical 1 cycle/deg sine-wave gratings in the presence of left or right oblique (±45 deg) 3 cycles/deg mask gratings with contrast C%, or a plaid made from their sum, where each component (i) had contrast 0.5Ci%. Masks and targets were presented to two eyes (binocular), one eye (monoptic), or different eyes (dichoptic). Binocular-masking functions superimposed when plotted against C, but in the monoptic and dichoptic conditions, the grating produced slightly more suppression than the plaid when Ci ≥ 16%. We tested contrast gain control models involving two types of contrast combination on the denominator: (1) spatial pooling of the mask after a local nonlinearity (to calculate either root mean square contrast or energy) and (2) “linear suppression” (Holmes & Meese, 2004, Journal of Vision4, 1080–1089), involving the linear sum of the mask component contrasts. Monoptic and dichoptic masking were typically better fit by the spatial pooling models, but binocular masking was not: it demanded strict linear summation of the Michelson contrast across mask orientation. Another scheme, in which suppressive pooling followed compressive contrast responses to the mask components (e.g., oriented cortical cells), was ruled out by all of our data. We conclude that the different processes that underlie monoptic and dichoptic masking use the same type of contrast pooling within their respective suppressive fields, but the effects do not sum to predict the binocular case.
Membrane frizzled-related protein is necessary for the normal development and maintenance of photoreceptor outer segments
Authors: WON JUNGYEON , SMITH RICHARD S. , PEACHEY NEAL S. , WU JIANG , HICKS WANDA L. , NAGGERT JÜRGEN K. , NISHINA PATSY M. 
Published: September 2008

AbstractA 4 base pair deletion in a splice donor site of the Mfrp (membrane-type frizzled-related protein) gene, herein referred to as Mfrprd6/rd6, is predicted to lead to the skipping of exon 4 and photoreceptor degeneration in retinal degeneration 6 (rd6) mutant mice. Little, however, is known about the function of the protein or how the mutation causes the degenerative retinal phenotype. Here we examine ultrastructural changes in the retina of Mfrprd6/rd6 mice to determine the earliest effects of the mutation. We also extend the reported observations of the expression pattern of the dicistronic Mfrp/C1qtnf5 message and the localization of these and other retinal pigment epithelium (RPE) and retinal proteins during development and assess the ability of RPE cells to phagocytize outer segments (OSs) in mutant and wild-type (WT) mice. At the ultrastructural level, OSs do not develop normally in Mfrprd6/rd6 mutants. They are disorganized and become progressively shorter as mutant mice age. Additionally, there are focal areas in which there is a reduction of apical RPE microvilli. At P25, the rod electroretinogram (ERG) a-wave of Mfrprd6/rd6 mice is reduced in amplitude by ~50% as are ERG components generated by the RPE. Examination of β-catenin localization and Fos and Tcf-1 expression, intermediates of the canonical Wnt pathway, showed that they were not different between mutant and WT mice, suggesting that MFRP may operate through an alternative pathway. Finally, impaired OS phagocytosis was observed in Mfrprd6/rd6 mice both in standard ambient lighting conditions and with bright light exposure when compared to WT controls.
A pattern for almost compositional functions
Authors: BRINGERT BJÖRN , RANTA AARNE 
Published: September 2008

AbstractThis paper introduces a pattern for almost compositional functions over recursive data types, and over families of mutually recursive data types. Here “almost compositional” means that for all of the constructors in the type(s), except a limited number of them, the result of the function depends only on the constructor and the results of calling the function on the constructor's arguments. The pattern consists of a generic part constructed once for each data type or family of data types, and a task-specific part. The generic part contains the code for the predictable compositional cases, leaving the interesting work to the task-specific part. Examples of the pattern are given, implemented in dependent type theory with inductive families, in Haskell with generalized algebraic data types and rank-2 polymorphism, and in Java using a variant of the Visitor design pattern. The relationships to the “Scrap Your Boilerplate” approach to generic programming, and to general tree types in dependent type theory, are investigated by reimplementing our operations using those frameworks.
Hoare type theory, polymorphism and separation
Authors: NANEVSKI ALEKSANDAR , MORRISETT GREG , BIRKEDAL LARS 
Published: September 2008

AbstractWe consider the problem of reconciling a dependently typed functional language with imperative features such as mutable higher-order state, pointer aliasing, and nontermination. We propose Hoare type theory (HTT), which incorporates Hoare-style specifications into types, making it possible to statically track and enforce correct use of side effects.The main feature of HTT is the Hoare type {P}x:A{Q} specifying computations with preconditionPand postconditionQthat return a result of typeA. Hoare types can be nested, combined with other types, and abstracted, leading to a smooth integration with higher-order functions and type polymorphism.We further show that in the presence of type polymorphism, it becomes possible to interpret the Hoare types in the “small footprint” manner, as advocated by separation logic, whereby specifications tightly describe the state required by the computation.We establish that HTT is sound and compositional, in the sense that separate verifications of individual program components suffice to ensure the correctness of the composite program.