bluuebunny/crossref_metadata_2025_split huggingface dataset:
p53 correlates with improved survival in patients with esophageal adenocarcinoma
Authors: Sauter Edward R. , Keller Steven M. , Erner Susan M. 
Published: February 2007

AbstractEsophageal adenocarcinoma is a virulent malignancy that is rapidly increasing in incidence. Overexpression of p53, a tumor‐suppressor gene with prognostic significance in many malignancies, has not been adequately evaluated in this disease. The purpose of this study was to evaluate the pattern and importance of p53 protein accumulation in patients with esophageal adenocarcinoma. Immunohistochemical analysis was performed on formalin‐fixed, paraffin‐embedded tissue from 24 patients, all of whom had early stage disease. Nineteen of 24 patients underwent surgery, and 16 had complete tumor resection. p53 oncoprotein immuno‐reactivity was demonstrated in 50% (12/24) of patients overall and 50% (8/16) of patients undergoing esophagectomy. p53 overexpression was more common in patients with well‐differentiated tumors (P=0.07). The tissue surrounding tumor stained positive for p53 in six patients, four of whom had no evidence of Barrett's epithelium. Among the 16 patients who underwent esophagectomy, those whose tumors demonstrated p53 overexpression had a longer overall (28 vs. 13.5 months) and disease‐free (24.3 vs. 13 months) median survival. The difference in disease‐free survival was significant (P=0.05). Our findings suggest that p53 overexpression may serve as a marker of improved survival in patients with esophageal adenocarcinoma. © 1995 Wiley‐Liss, Inc.
Combined local hyperthermia and immunotherapy treatment of an experimental subcutaneous murine melanoma
Authors: Geehan Douglas M. , Fabian Dagmar F. , Lefor Alan T. 
Published: February 2007

AbstractImmunotherapy (IT) has become an accepted therapeutic modality for a limited number of tumor types. One of the limiting factors in the use of interleukin‐2 (IL‐2) has been dose‐related toxicity. We undertook these studies to study the effects of combined therapy on a murine melanoma. The B 16 melanoma was implanted in the right hindlimb of C57BL/6 mice and therapy begun on day 3 (microscopic tumor model) or day 10 (macroscopic tumor model). Animals were divided into four groups: No therapy, local hyperthermia (HT) alone (45°C ± 15 minutes on days 3 and 6 or days 10 and 13), HT + IL‐2 at 300,000 IU ip tid, and HT + IL‐2 at 600,000 IU ip tid. We have shown in multiple previous experiments that IL‐2 alone at these doses has no effect on tumor growth; these groups were omitted. In the microscopic model, tumors in the no treatment group were an average of 400 mm2. Animals treated with HT alone had a mean tumor size of 300 mm2. However, tumors in animals receiving both therapeutic modalities measured a mean of 100 mm2 (300,000 IU IL‐2 ip tid) and 80 mm2 (600,000 IU IL‐2 ip tid). In the macroscopic tumor model, tumors in animals receiving no treatment were an average of 7.5 times larger than on day 10, in animals receiving HT alone were an average of 5 times larger, animals receiving IL‐2 were 2.95 times larger (both dose levels). These results show that combined IT + HT therapy resulted in significantly (p < .05) reduced growth with both microscopic and macroscopic tumors compared to HT alone or no therapy in a murine subcutaneous melanoma model using doses significantly lower than those usually needed to observe a therapeutic response with IL‐2 used alone. This study further supports the use of this combined modality approach in patients with advanced malignancies.
Estrogen and progesterone receptors in malignant mixed mesodermal tumors of the ovary
Authors: Geisler John P. , Wiemann Michael C. , Miller Greg A. , Zhou Zhen , Geisler Hans E. 
Published: February 2007

AbstractMalignant mixed mesodermal tumors of the ovary occur in less than 1% of cases of ovarian cancer. They have a dismal prognosis and the most effective type of therapy is still not known.All cases of malignant mixed mesodermal tumor of the ovary between Jaunary 1, 1985 and May 1, 1994 operated on by the gynecologic oncology service are the subject of this report. Data were obtained from the hospital and office records of the patients.Nine patients who had their primary surgery by the gynecologic oncology service were found to have the diagnosis of malignant mixed mesodermal tumor of the ovary. Homologous tumors were found in five patients and heterologous tumors in four. Homologous tumors (mean survival 15.2 months) showed a better survival than heterologous tumors (mean survival 6.5 months; P = 0.001). An elevated estrogen receptor status was shown to correspond to longer survival (p < 0.0001). Six specimens were considered to be estrogen receptor positive and three were receptor negative. The mean survival in those patients who had a positive estrogen receptor status, 13.7 months, with a median of 7.5 months was significantly higher than those who were not positive, 6.7 months (P = 0.019) with a median of 6.25 months. All specimens were progesterone receptor negative.Malignant mixed mesodermal tumors of the ovary have a dismal prognosis, no effective therapy, and controversial prognostic indicators. Increasing estrogen receptor status appeared to correlate with longer mean survival. Larger, multi‐institutional studies need to be done to determine the overall significance of these findings.
Squamous cell carcinoma complicating idiopathic inflammatory bowel disease
Authors: Kulaylat Mahmoud N. , Doerr Ralph , Butler Brian , Satchidanand Sateesh K. , Singh Amarjit 
Published: February 2007

AbstractSquamous cell carcinoma of the colon and rectum, originating proximal to the transitional zone, is a rare complication of idiopathic inflammatory bowel disease (IIBD). To date there are only 15 single case reports of such an occurrence. This carcinoma develops more commonly in females and in patients with pancolonic disease of more than 8 years' duration. The rectum is affected in two thirds of the cases. Squamous cell changes, in the vicinity of the primary adenocarcinoma, are present in 27% of cases. The carcinoma is in a pathologically advanced stage in one third of the cases. Colectomy is the main therapeutic modality. Survival following surgical resection ranged from 7 months to 21 years. We present an additional case of rectal squamous cell carcinoma (SCC) complicating chronic ulcerative colitis in a 33‐year‐old woman who had the disease for 15 years. Multiple biopsies of a gross lesion located 5 cm above the dendate line were consistent with invasive basaloid cell carcinoma. The patient received 5‐FU, mitomycin C, and radiotherapy prior to a proctocolectomy and ileostomy. The only histopathologic finding at pathologic review of the surgical specimen was severe squamous dysplasia.
Nuclear DNA content and nucleolar organizer regions in colorectal cancer
Authors: Adachi Yosuke , Kido Akinori , Mori Masaki , Matsushima Tetsuya , Shimono Reishi , Inoue Tetsuya , Sugimachi Keizo 
Published: February 2007

AbstractThe prognostic value of nuclear DNA content and argyrophilic nucleolar organizer regions (AgNOR) is still controversial in colorectal cancer. Sixty patients with colorectal cancer were studied by flow cytometric DNA analysis and AgNOR measurement, and their prognostic significance was tested. DNA index was closely linked to depth of invasion and lymph node metastasis, while AgNOR count did not correlate with such parameters. The survival curve was stongly influenced by depth of invasion, lymph node metastasis, and Dukes' stage but was not affected by DNA ploidy and AgNOR count. These results indicate that neither DNA ploidy nor AgNOR count correlates with survival of patients, although DNA ploidy is linked to progression of colorectal cancer.
Renal cell carcinoma: Comparison of the tnm and robson stage groupings
Authors: Guinan Patrick , Saffrin Robert , Stuhldreher David , Frank Walter , Rubenstein Marvin 
Published: February 2007

AbstractThis review compares the two major staging systems for renal cell carcinoma: the TNM and Robson systems. For purposes of worldwide clinical and scientific consistency, the TNM system is recommended. However, the primary tumor size cutoff of 2.5 cm. does not prognostically differentiate between stages I and II. A review of 337 patients with renal cell carcinoma, of whom 122 had stage I or II disease revealed that a 2.5‐cm cutoff did not predict survival differences, while cutoffs of 5.0, 7.5, and 10.0 cm did. Because 7.5 cm most closely approximates the mean renal cell cancer diameter as noted by SEER data, it is recommended that the TNM primary tumor cutoff be changed to 7.5 cm.
Tumor necrosis factor alpha stimulates gluconeogenesis from alanine in vivo
Authors: Blumberg David , Hochwald Steven , Burt Michael , Donner David , Brennan Murray F. 
Published: February 2007

AbstractAn increase in gluconeogenesis contributes to the cachexia seen in severe injury, sepsis, and malignancy by converting amino acids from skeletal muscle to glucose. Since tumor necrosis factor α (TNFα) may mediate this cachexia, we examined the effect of this cytokine on gluconeogenesis. Twenty‐eight male Fischer rats were injected intraperitoneally with TNFα (250 μg/kg) or saline, and after 4 hours, isolated hepatocytes were obtained by in situ collagenase liver perfusion. Hepatocytes were incubated with alanine (10 mM), and rates of gluconeogenesis were determined. Plasma lactate, glucose, insulin, glucagon, cortisol, and amino acids were measured. TNFα administration resulted in a 50% increase in gluconeogenesis from alanine (P <0.05) and a three‐fold increase in plasma glucagon (P = 0.01). Total and glucogenic plasma amino acids decreased with TNFα injection (P < 0.05). In vivo TNFα causes an increase in hepatic gluconeogenesis associated with increased plasma glucagon.
Vocal cord paralysis in patients with thoracic esophageal carcinoma
Authors: Tachimori Yuji , Kato Hoichi , Watanabe Hiroshi , Ishikawa Tsutomu , Yamaguchi Hajime 
Published: February 2007

AbstractOf 478 consecutive patients with intrathoracic esophageal carcinoma, 5% had vocal cord paralysis. In two thirds of the patients with vocal cord paralysis, the paralysis was caused by a metastatic lymph node located along the recurrent laryngeal nerve. These findings indicate that the possibility exists for radical surgery by esophagectomy and resection of the metastatic lymph node infiltrating the recurrent laryngeal nerve, even in patients with vocal cord paralysis. However, in only two patients was radical surgery accomplished. None of the 24 patients with paralysis survived without disease for more than 1 year. Thus, in patients with vocal cord paralysis, the need for combined therapy should be emphasized.
Characteristics of non‐small cell lung cancer 3 cm or less in diameter
Authors: Tateishi Masahiro , Fukuyama Yasurou , Hamatake Motoharu , Kohdono Satoshi , Mitsudomi Tetsuya , Ishida Teruyoshi , Sugimachi Keizo 
Published: February 2007

AbstractWe retrospectively investigated 308 cases of non‐small cell lung cancer of ≥3 cm diameter. There were 204 adenocarcinomas, 78 squamous cell carcinomas, 15 large cell carcinomas, and 11 other carcinomas. According to TNM staging, there were one case stage 0, 208 stage I, 22 stage II, 49 stage IIIA, 15 stage IIIB, and 13 cases stage IV. T1 disease was seen in 262 cases, T2 in 19, T3 in 10, T4 in 16, and Tis in 1. No disease was seen in 217 cases, N1 in 30, N2 in 60, and N3 in 1. The 5‐year survival rate of all case was 63%. There were statistically significant differences amont T status (T1 vs. T3, T4), N status (N0 vs. N1, N2), and M status (M0 vs. M1) (P < 0.01). The 5‐year survival rates of cases with adenocarcinoma and squamous cell carcinoma were 60% and 64%, respectively. In 204 cases of adenocarcinoma, T3 disease was found in one case, T4 disease in 15 (7%), and nodal involvement (N1 + N2) was present in 69 (34%). In 78 cases of squamous cell carcinoma T3 was seen in 6 (8%), T4 in 1, and nodal involvement in 14 (18%). The incidence of T3 disease, T4, and N(+) varied significantly according to histology (P < 0.05). Our investigation suggested that cases of small‐sized lung cancer were often at an advanced stage at detection, and that the spread of disease differed according to histology. The patient with small‐sized lung cancer should be offered a standard operation regardless of histology.
Primary gastrointestinal lymphoma: 30‐year experience at the cancer institute, madras, india
Authors: Ramesh Chandran R. , Hemanth Raj E. , Chaturvedi Harit K. 
Published: February 2007

AbstractA retrospective study was conducted of 49 patients with primary gastrointestinal lymphoma to analyze clinicopathological features, prognostic factors, and results of treatment. Intestinal lymphomas (63%) were more common than gastric lymphomas (29%). Endoscopic biopsy was diagnostic in 64% of gastric lymphomas, while 97% of intestinal lymphomas required laparotomy for diagnosis. Lymphoblastic (35%) and diffuse large cell (33%) lymphomas were the most frequent histologic types. Complete remission (CR) was achieved in 61% of patients, with a 5‐year survival of 72% in those who achieved CR. The overall 5‐year survival and disease‐free survival were 47% and 40%, respectively. All disease‐related mortality occurred within 2 years of diagnosis, with 79% occurring in the first year. There was no overall significant difference in survival between the different treatment groups. Stage, extent of surgical resection, response to treatment, serosal involvement, multimodality treatment, and performance status were significant prognostic factors. Achievement of complete remission and complete surgical resection were the most favorable independent prognostic factors on multivariate analyses. © 1995 Wiley‐Liss, Inc.
Overexpression of p‐glycoprotein in untreated AFP‐producing gastric carcinoma
Authors: Dhar Dipok Kumar , Nagasue Naofumi , Yoshimura Hiroshi , Tachibana Mitsuo , Tahara Hideki , Matsuura Hiroshi , Abe Shun'Ichi , Chang Yu‐Chung , Nakamura Teruhisha 
Published: February 2007

AbstractP‐glycoprotein (P‐gly), which is responsible for the phenotypic expression of multidrug resistance in cancerous tissue was stained immunohistochemically in previously untreated α‐fetoprotein (AFP)‐producing (n = 20) and nonproducing gastric cancers (n = 20). P‐gly, AFP, and carcinoembry‐onic antigen(CEA) were stained in formalin‐fixed paraffin‐embedded tissue sections immunohistochemically using the monoclonal antibody JSB‐1, anti‐AFP, and anti‐CEA, respectively. DNA ploidy pattern was determined by Fluorescence Activated Cell Sorter (FACS) analyzer.P‐gly was significantly overexpressed in AFP producing gastric cancers (60%) than in AFP nonproducing ones (20%) (P < 0.01). When the result of P‐gly staining was analyzed among the AFP‐positive cases, P‐gly positivity did not emerge either as a significant prognostic factor or as a predictor of the metastatic potentiality of the tumor. The intrinsic overexpression of P‐gly in AFP producing gastric cancers proves its biological and morphological similarities to hepatocellular carcinoma. The significantly (P < 0.05) higher incidence of P‐gly in diploid tumors indicate that expression of this phenotype might be related to the differentiation of the tumor.P‐gly was overexpressed in AFP producing gastric carcinoma and the existing drug resistance, frequent recurrence, and poor prognosis might be explained by presence of P‐gly in this carcinoma. © 1995 Wiley‐Liss, Inc.
Treatment of breast cancer in elderly patients
Authors: Van Dalsen Annette D. , De Vries Johannes E. 
Published: February 2007

AbstractThe objective of this study was to analyze the treatment and its results in breast cancer of the elderly. Special attention was given to the primary treatment with tamoxifen alone. We reviewed 210 patients over 70 years old with breast cancer treated between 1980 and 1992. Mean follow‐up time was 41 months. Tamoxifen was given as primary treatment in 34 patients without distant metastases; 147 patients without distant metastases underwent surgery. Local or regional recurrence occurred in 6% of the patients who had surgery. Local progressive disease was reported in 27% of those treated with tamoxifen (P < 0.005). These patients had further surgery. There was no difference between the two groups in overall survival of patients and occurrence of metastases. We concluded that optimal treatment of breast cancer in the elderly should include surgery. Only patients with very limited life expectancy should receive tamoxifen alone. © 1995 Wiley‐Liss, Inc.
Typical medullary carcinoma of the breast: A clinical and pathological analysis of 52 cases
Authors: Reinfuss Marian , Stelmach Andrzej , Mitus Jerzy , Rys Janusz , Duda Krzysztof 
Published: February 2007

AbstractFifty‐two women with typical medullary breast carcinoma, diagnosed according to criteria of Ridolfi et al. [Cancer 40:1365–1385, 1977] are described. At the time of diagnosis, 90% of the patients were stages I and II. The primary tumor size was ≦ to 4 cm in 46 (88.5%) and > 4 cm in 6 (11.5%) patients. Axillary lymph nodes were microscopically negative in 35 (67.3%) and positive in 17 (32.7%) patients. All 52 women underwent the Patey operation. Seventeen patients with microscopically positive axillary lymph nodes received postoperative irradiation. Of the 52 treated patients, 44 (84.6%) survived 10 years NED. The only prognostic factor was the microscopical axillary lymph nodes status. In the group of pNO patients, 97.1% survived 10 years NED, pN+ 58.8% only. The sole causes of unsuccessful treatment were distant metastases to lungs, hepar, and bones. Typical medullary carcinoma is a favorable histological type of breast carcinoma with very good prognosis for pNO patients. © 1995 Wiley‐Liss, Inc.
Collagen promotes perianastomotic tumour growth in an experimental animal model
Authors: Reinbach Diana , McGregor John R. , Dahill Steven W. , Docherty James G. , O'Dwyer Patrick J. 
Published: February 2007

AbstractLocal application of growth factors promote wound healing and may find clinical application for use in high‐risk intestinal anastomoses such as that following anterior resection. Since viable tumour cells are present in the bowel lumen and circulation after curative colorectal cancer surgery, it is unclear what effect such factors may have on tumour recurrence. The aim of this study was to examine the effect of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) in a collagen suspension on perianastomotic tumour growth in an animal model. Significantly (P < 0.05) more animals in the collagen treated groups developed anastomotic tumours. The area of tumour growth at the anastomosis was also significantly greater for the collagen (median 14.7 mm2) and collagen + EGF (median 10.8 mm2) groups compared with controls (median 0.78 mm2). We were unable to demonstrate any promotion of tumour by growth factors alone. Collagen promotes perianastomotic tumour growth in this model and is not a suitable vehicle for growth factor application in colorectal cancer surgery. © 1995 Wiley‐Liss, Inc.
Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer
Authors: James Iii H. Wallace , Willett Christopher G. , Shellito Paul C. , Coen John J. , Hoover Herbert C. 
Published: February 2007

AbstractRecurrent rectal or rectosigmoid cancer is a difficult therapeutic problem. A treatment program of external beam irradiation, surgery, and intraoperative irradiation has been used for 41 patients. The 5‐year actuarial local control and disease‐free survival of all 41 patients was 30% and 16%, respectively. Subset analysis demonstrated differences in outcome by extent of surgical resection. The 5‐year actuarial local control and disease‐free survival of 27 patients undergoing complete resection was 47% and 21%, respectively. By contrast, the outcome of 14 patients undergoing partial resection was poor, with a 5‐year actuarial local control and survival of 21% and 7%, respectively. Late complications included soft tissue or peripheral nerve injury, with many of these resolving within 4–18 months. Local control and disease‐free survival rates are favorable in comparison with the results achieved by aggressive surgery. Patients who achieve a gross total resection at intraoperative irradiation have a markedly better prognosis than that of patients with residual gross disease. © 1995 Wiley‐Liss, Inc.
Sinus histiocytosis mimicking metastatic melanoma in lymph nodes of a patient with a large joint prosthesis: Case report and review of the literature
Authors: Charny Caleb K. , Jacobowitz Glenn , Melamed Jonathan , Tata Mona , Harris Matthew N. 
Published: February 2007

AbstractMalignant melanoma metastases to regional lymph nodes may be mimicked by several non‐neoplastic processes, including sinus histiocytosis induced by fragments shed from joint prostheses. A patient who had an elective lymph node dissection for malignant melanoma and was found to have “post‐prosthesis lymph node histiocytosis” resembling metastatic disease is described. Knowledge of the patient's past history of a total shoulder joint replacement along with the use of polarized light microscopy to identify birefringent particles of prosthetic debris allows for an accurate histologic diagnosis. © 1995 Wiley‐Liss, Inc.
Analysis of proliferative activity using antiproliferating cell nuclear antigen antibody in colorectal cancer
Authors: Nakae Shiro , Nakamura Takeshi , Shirono Junko , Yoshioka Hiroshi , Ikegawa Ryuichiro , Miyamura Kazuo , Kawasaki Kentaro , Saitoh Yoichi , Tabuchi Yoshiki 
Published: February 2007

AbstractUsing anti‐PCNA antibody (PC10), an immunohistochemical study of the expression of PCNA in formalin‐fixed and paraffin‐embedded materials of colorectal cancer patients was performed and correlation of PCNA expression with clinicopathological findings and DNA ploidy pattern was studied. PCNA labeling rate (PCNA LR) was estimated in the advancing margin of the tumor and ranged from 23.8% to 77.9%. There was a significant difference in lymphatic vessel invasion, liver metastasis and Dukes' stage between the groups with high (>48.7) and low (<48.7) PCNA LR (P < 0.05). No differences were seen in tumor size, histological type, lymphnode metastasis or DNA ploidy pattern. In patients with younger age, infiltration to neighboring organs, a high degree of venous invasion, and peritoneal dissemination, the frequency of high PCNA LR tended to be higher (P<0.1). The results above suggest that a high proliferative activity as defined by evaluation of the PCNA LR at the advancing margin of the tumor may be one of the parameters of malignant potential and helpful as a predictor of liver metastasis in colorectal cancer. © 1995 Wiley‐Liss, Inc.
Venous gas embolism during cryosurgery for bone tumors
Authors: Bart Schreuder H. W. , Van Beem Herman B. H. , Veth René P. H. 
Published: February 2007

AbstractCryosurgery using liquid nitrogen is a method for treating benign‐ and low‐malignant skeletal tumors. The advantage of preserving the supportive function of bone should be compared to the risk for its complications; postoperative fracture is well known, but less so the occurrence of intraop‐erative venous gas embolism. This paper describes 17 patients: 2 patients who had serious hemodynamic complications during cryosurgery and a study of 15 patients in whom end‐tidal N2 tension was measured in an attempt to investigate the clinical incidence of venous gas embolism during cryosurgery. In the 15 cases analyzed, we did not detect any exhaled N2 during cryosurgery. © 1995 Wiley‐Liss, Inc.