bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors for Hamstring Graft Diameter in Anterior Cruciate Ligament Reconstruction
Authors: Tuman Jeffrey M. , Diduch David R. , Rubino L. Joseph , Baumfeld Joshua A. , Nguyen Henry S. , Hart Joseph M. 
Published: July 2007

Background The ability to accurately predict the diameter of autograft hamstring tendons has implications for graft choice and fixation devices used in anterior cruciate ligament (ACL) reconstruction. Purpose To determine whether simple anthropometric measurements such as height, mass, body mass index (BMI), age, and gender can be used to accurately predict the diameter of hamstring tendons for ACL reconstruction surgery. Study Design Cohort study (prevalence); Level of evidence, 2. Methods The authors conducted medical record reviews and telephone interviews of 106 consecutive patients with ACL reconstruction using quadrupled semitendinosus-gracilis autograft from 2004 to 2006. Data included anthropometric measurements (height, mass, gender, and age at the time of surgery). Hamstring diameter was obtained using cylindrical sizers in 0.5-mm increments and recorded in the patient's surgical record. Correlation coefficients (Pearson r) and stepwise, multiple linear regression were used to determine the relationship between the outcome variable (hamstring graft diameter) and the predictor variables (age, gender, height, mass, and BMI). Independent sample t tests were used to compare hamstring graft diameter between genders. Results Hamstring graft diameter was related to height (r = .36, P < .001), mass (r = .25, P = .005), age (r = —.16, P = .05), and gender (r = —.24, P = .006) but was not related to BMI (P > .05). Height was a statistically significant prediction variable (R2 = .13, P < .001). From the current data, a regression equation was calculated that suggested that a patient <147 cm (58 in) tall is likely to have a quadrupled hamstring graft diameter <7 mm in diameter (graft size = 2.4 + 0.03 × height in cm). Women had significantly smaller hamstring graft diameters (7.5 ± 0.7 mm) than did men (7.9 ± 0.9 mm, P = .01). Conclusions Of the parameters studied, height was the best predictor of hamstring tendon diameter, particularly in women.
RNA fingerprints provide direct evidence for the inhibitory role of TGFβ and PD-1 on CD4+ T cells in Hodgkin lymphoma
Authors: Chemnitz Jens M. , Eggle Daniela , Driesen Julia , Classen Sabine , Riley James L. , Debey-Pascher Svenja , Beyer Marc , Popov Alexey , Zander Thomas , Schultze Joachim L. 
Published: July 2007

AbstractA hallmark of various human malignancies is the expression of immunoinhibitory factors within the tumor microenvironment. There is indirect evidence based on in vitro experiments that tumor-infiltrating T cells in human malignancies are suppressed by such factors. Still, direct evidence of the influence of individual inhibitory factors on immune cells in human cancer in vivo is lacking. To address this question, we used Hodgkin lymphoma (HL) as a model because histopathological characteristics of HL are thought to be due mostly to the effects of a wide variety of cytokines, including TGFβ or membrane-bound receptors such as PD-1 that are suspected to contribute to immune evasion of tumor cells. Using a genome-wide transcriptional approach, we established specific RNA fingerprints of TGFβ and PD-1 signaling in human T cells in vitro. Applying these specific fingerprints, we directly demonstrate that CD4+ T cells in HL—but not in follicular lymphoma (FL)—are under the inhibitory influence of both TGFβ and PD-1 in vivo. This approach can be easily generalized to provide direct evidence of the impact of any given soluble or cell-bound factor on any cell type within diseased tissue.
Cited2 is required for normal hematopoiesis in the murine fetal liver
Authors: Chen Yu , Haviernik Peter , Bunting Kevin D. , Yang Yu-Chung 
Published: July 2007

AbstractCited2 (cAMP-responsive elementbinding protein [CBP]/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]–rich tail 2) is a newly identified transcriptional modulator. Knockout of the Cited2 gene results in embryonic lethality with embryos manifesting heart and neural tube defects. Cited2−/− fetal liver displayed significant reduction in the numbers of Lin−c-Kit+Sca-1+ cells, Lin−c-Kit+ cells, and progenitor cells of different lineages. Fetal liver cells from Cited2−/− embryos gave rise to markedly reduced number of colonies in the colony-forming unit assay. Primary and secondary transplantation studies showed significantly compromised reconstitution of T-lymphoid, B-lymphoid, and myeloid lineages in mice that received a transplant of Cited2−/− fetal liver cells. Competitive reconstitution experiments further showed that fetal liver hematopoietic stem cell (HSC) function is severely impaired due to Cited2 deficiency. Microarray analysis showed decreased expression of Wnt5a and a panel of myeloid molecular markers such as PRTN3, MPO, Neutrophil elastase, Cathepsin G, and Eosinophil peroxidase in Cited2−/− fetal livers. Decreased expression of Bmi-1, Notch1, LEF-1, Mcl-1, and GATA2 was also observed in Cited2−/− Lin−c-Kit+ cells. The present study uncovers for the first time a novel role of Cited2 in the maintenance of hematopoietic homeostasis during embryogenesis and thus provides new insights into the molecular regulation of hematopoietic development.
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
Authors: Kim Nayoung , Saudemont Aurore , Webb Louise , Camps Montserrat , Ruckle Thomas , Hirsch Emilio , Turner Martin , Colucci Francesco 
Published: July 2007

AbstractThe signal transduction pathways that lead activated natural killer (NK) cells to produce cytokines, releases cytotoxic granules, or do both, are not clearly dissected. For example, phosphoinositide 3-kinases (PI3Ks) are key players in the execution of both functions, but the relative contribution of each isoform is unknown. We show here that the catalytic isoform p110δ, not p110γ, was required for interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and granulocyte macrophage colony-stimulating factor (GM-CSF) secretion, whereas neither was necessary for cytotoxicity. Yet, when both p110δ and p110γ isoforms were inactivated by a combination of genetic and biochemical approaches, cytotoxicity was decreased. NK-cell numbers were also affected by the lack of p110δ but not p110γ and more severely so in mice lacking both subunits. These results provide genetic evidence that p110δ is the dominant PI3K isoform for cytokine secretion by NK cells and suggest that PI3Ks cooperate during NK-cell development and cytotoxicity.
Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon
Authors: Binette Tanya M. , Taylor Fletcher B. , Peer Glenn , Bajzar Laszlo 
Published: July 2007

AbstractThrombin activatable fibrinolysis inhibitor (TAFI), when activated, forms a basic carboxypeptidase that can inhibit fibrinolysis. Potential physiologic activators include both thrombin and plasmin. In vitro, thrombomodulin and glycosaminoglycans increase the catalytic efficiency of TAFI activation by thrombin and plasmin, respectively. The most relevant (patho-) physiologic activator of TAFI has not been disclosed. Our purpose was to identify the physiologic activator of TAFI in vivo. Activation of protein C (a thrombin-thrombomodulin–dependent reaction), prothrombin, and plasminogen occurs during sepsis. Thus, a baboon model of Escherichia coli–induced sepsis, where multiple potential activators of TAFI are elaborated, was used to study TAFI activation. A monoclonal antibody (mAbTAFI/TM#16) specifically inhibiting thrombin-thrombomodulin–dependent activation of TAFI was used to assess the contribution of thrombin-thrombomodulin in TAFI activation in vivo. Coinfusion of mAbTAFI/TM#16 with a lethal dose of E coli prevented the complete consumption of TAFI observed without mAbTAFI/TM#16. The rate of fibrin degradation products formation is enhanced in septic baboons treated with the mAbTAFI/TM#16; therefore, TAFI activation appears to play a key role in the extent of fibrin(ogen) consumption during E coli challenge, and thrombin-thrombomodulin, in a baboon model of E coli–induced sepsis, appears to be the predominant activator of TAFI.
CD45RO enriches for activated, highly mutated human germinal center B cells
Authors: Jackson Stephen M. , Harp Natessa , Patel Darshna , Zhang Jeffrey , Willson Savannah , Kim Yoon J. , Clanton Christian , Capra J. Donald 
Published: July 2007

AbstractTo date, there is no consensus regarding the influence of different CD45 isoforms during peripheral B-cell development. Examining correlations between surface CD45RO expression and various physiologic processes ongoing during the germinal center (GC) reaction, we hypothesized that GC B cells, like T cells, that up-regulate surface RO should progressively acquire phenotypes commonly associated with activated, differentiating lymphocytes. GC B cells (IgD−CD38+) were subdivided into 3 surface CD45RO fractions: RO−, RO+/−, and RO+. We show here that the average number of mutations per IgVH transcript increased in direct correlation with surface RO levels. Conjunctional use of RO and CD69 further delineated low/moderately and highly mutated fractions. Activation-induced cytidine deaminase (AID) mRNA was slightly reduced among RO+ GC B cells, suggesting that higher mutation averages are unlikely due to elevated somatic mutation activity. Instead, RO+ GC B cells were negative for Annexin V, comprised mostly (93%) of CD77− centrocytes, and were enriched for CD69+ cells. Collectively, RO+ GC B cells occupy what seems to be a specialized niche comprised mostly of centrocytes that may be in transition between activation states. These findings are among the first to sort GC B cells into populations enriched for live mutated cells solely using a single extracellular marker.
The distal location of the iron responsive region of the hepcidin promoter
Authors: Truksa Jaroslav , Lee Pauline , Peng Hongfan , Flanagan Jonathan , Beutler Ernest 
Published: July 2007

Abstract
The response of hepcidin transcription to iron has been repeatedly documented in living mice, but it is difficult to demonstrate the response in ex vivo systems. We have hydrodynamically transfected mice with plasmid constructs composed of a murine hepcidin 1 promoter and fragments of the promoter fused to a firefly luciferase reporter. This method enabled us to quantitate the response of the hepcidin promoter to short-term feeding of a high-iron diet to mice that have been maintained on an iron-deficient diet. We show that the region of the promoter between 1.6 Kb and 1.8 Kb upstream from the start of translation is essential for the response to iron. The promoter region between −260 bp and −1.6 Kb is not essential for the iron responsiveness of hepcidin promoter. The iron-responsive region that we have mapped is the same region required for the in vitro response of HepG2 cells to stimulation with bone morphogenetic proteins and differs from the LPS/IL-6 responsive area.
The revised WHO diagnostic criteria for Ph-negative myeloproliferative diseases are not appropriate for the diagnostic screening of childhood polycythemia vera and essential thrombocythemia
Authors: Teofili Luciana , Giona Fiorina , Martini Maurizio , Cenci Tonia , Guidi Francesco , Torti Lorenza , Palumbo Giovanna , Amendola Angela , Leone Giuseppe , Foà Robin , Larocca Luigi M. 
Published: July 2007

Abstract
In the proposed revised World Health Organization (WHO) criteria for the diagnosis of BCR-ABL− myeloproliferative diseases (MPDs), exclusion criteria have been replaced by the presence of JAK2 mutations. We applied these criteria to 45 children with MPDs: 13 with polycythemia vera (PV) and 32 with essential thrombocythemia (ET). Among these 45 patients, 12 with ET and 5 with PV had a familial history of MPD, and had been investigated for hereditary mutations of the erythropoietin receptor, thrombopoietin, or MPL genes. We found that the JAK2V617F mutation in children occurs less frequently than in adults, and that exon 12 JAK2 mutations are absent. On the basis of the revised WHO criteria, a significant proportion of childhood PVs were misdiagnosed. Furthermore, all familial ET, including patients carrying the hereditary MPLSer505Asn activating mutation, were erroneously diagnosed as MPDs. Our observations suggest that childhood MPDs require a set of specific diagnostic criteria.
Applying negative rule mining to improve genome annotation
Authors: Artamonova Irena I , Frishman Goar , Frishman Dmitrij 
Published: July 2007

Abstract

Background
Unsupervised annotation of proteins by software pipelines suffers from very high error rates. Spurious functional assignments are usually caused by unwarranted homology-based transfer of information from existing database entries to the new target sequences. We have previously demonstrated that data mining in large sequence annotation databanks can help identify annotation items that are strongly associated with each other, and that exceptions from strong positive association rules often point to potential annotation errors. Here we investigate the applicability of negative association rule mining to revealing erroneously assigned annotation items.

Results
Almost all exceptions from strong negative association rules are connected to at least one wrong attribute in the feature combination making up the rule. The fraction of annotation features flagged by this approach as suspicious is strongly enriched in errors and constitutes about 0.6% of the whole body of the similarity-transferred annotation in the PEDANT genome database. Positive rule mining does not identify two thirds of these errors. The approach based on exceptions from negative rules is much more specific than positive rule mining, but its coverage is significantly lower.

Conclusion
Mining of both negative and positive association rules is a potent tool for finding significant trends in protein annotation and flagging doubtful features for further inspection.
Gastric carcinoma: review of the results of treatment in a community teaching hospital
Authors: Heemskerk Vincent H , Lentze Fanneke , Hulsewé Karel WE , Hoofwijk Anton GM 
Published: July 2007

Abstract

Background
The aim of this study is to provide data on long term results of gastric cancer surgery and in particular the D1 gastric resection.

Methods
In the period 1992-2004, 235 male and female patients with a median age of 69 and 70 years respectively, were included with a stage I through IV gastric carcinoma, of which 37% was stage IV disease. Whenever possible a gastric resection was performed. In case of obstructive tumour growth palliation was provided by means of a gastro-enterostomy.

Results
Gastrectomy with curative intent was achieved in 50%, palliative resection in 22%, palliative surgery (gastro-enterostomy) in 10% and in 18% irresectability led to surgical exploration only. Patients in the curative intent group demonstrated a 47% survival after 5 years and up to 34% after 10 years. However metastases where seen in 32% of the patients after gastrectomy with curative intent. After palliative resection one year survival was 57%, whereas 19% survived more than 3 years. Overall postoperative morbidity and mortality rates were 40% and 13% respectively.

Conclusion
Long term survival after surgery for gastric cancer is poor and is improved by early detection and radical resection. However, palliative resection showed improved survival compared to gastro-enterostomy alone or no resection at all which may be an effect of adjuvant therapy.
High-throughput analysis of spatio-temporal dynamics in Dictyostelium
Authors: Sawai Satoshi , Guan Xiao-Juan , Kuspa Adam , Cox Edward C 
Published: July 2007

AbstractWe demonstrate a time-lapse video approach that allows rapid examination of the spatio-temporal dynamics of Dictyostelium cell populations. Quantitative information was gathered by sampling life histories of more than 2,000 mutant clones from a large mutagenesis collection. Approximately 4% of the clonal lines showed a mutant phenotype at one stage. Many of these could be ordered by clustering into functional groups. The dataset allows one to search and retrieve movies on a gene-by-gene and phenotype-by-phenotype basis.
A Review of wheel wear and rolling contact fatigue
Authors: Tunna J , Sinclair J , Perez J 
Published: July 2007

Railway wheels lives are limited by wear and the formation of rolling contact fatigue (RCF) damage. This review describes how the forces that cause wear and RCF on wheels are generated. It is demonstrated that shear stresses at and just below the surface are driven by forces generated during steady-state curving. Repeated applications of plastic shear stresses causes shear deformation of the material at and just below the wheel's surface. This can eventually lead to the formation and growth of surface cracks. Depending on the contact conditions, the surface cracks can develop into either wear or RCF. Tangential and normal forces, contact pressure, creepage, and the presence of fluid are important factors in determining the amount of wear and RCF. High strength wheel steels have been developed to withstand severe service loads. New materials and treatments are being developed to extend wheel life. The references quoted in this review show that RCF and wear of rails and wheels have been the subject of investigation for over 25 years. Several well-developed models exist for predicting wheel and rail wear. New models are emerging for rail RCF. These need to be further developed to be applicable to wheels.
Novel 2D Interpenetrated Structure and Occurrence of the Spin-crossover Phenomena of Assembled Complexes, Fe(NCX)2(bpp)2 (X = S, Se, BH3; bpp = 1,3-Bis(4-pyridyl)propane)
Authors: Atsuchi Masaki , Higashikawa Hiroyuki , Yoshida Yusuke , Nakashima Satoru , Inoue Katsuya 
Published: July 2007

Abstract
Assembled complexes, Fe(NCX)2(bpp)2 (X = S, Se, BH3; bpp = 1,3-bis(4-pyridyl)propane), have been synthesized. Fe(NCS)2(bpp)2 had a novel 2D interpenetrated structure and showed a temperature-independent HS state, while Fe(NCSe)2(bpp)2 and Fe(NCBH3)2(bpp)2 exhibited a slight decrease in χMT and a complete spin-crossover phenomenon (T1⁄2=123 K), respectively.
A Multifunctional Heterogeneous Catalyst: Titanium-containing Mesoporous Silica Material Encapsulating Magnetic Iron Oxide Nanoparticles
Authors: Mori Kohsuke , Kondo Yuichi , Morimoto Shotaro , Yamashita Hiromi 
Published: July 2007

Abstract
Magnetic iron oxide nanoparticles coated with mesoporous silica involving single-site titanium oxide moiety have been first developed by adopting a two-step coating method. The catalytic performance and magnetically separable ability were demonstrated in the oxidation of 2,6-di-tert-butylphenol using hydrogen peroxide.
Adsorption of n-Alkanes in Faujasite Zeolites: Molecular Simulation Study and Experimental Measurements
Authors: Wender Aurélie , Barreau Alain , Lefebvre Catherine , Di Lella Angela , Boutin Anne , Ungerer Philippe , Fuchs Alain H. 
Published: July 2007

An application of a previously developed force field for the adsorption of hydrocarbons onto silicalite (Pascual et al. 2003) to linear alkane/sodium faujasite systems is reported. In order to extend this force field from siliceous to cationic zeolites, it is proposed that account be taken of the polarization component of the zeolite-molecule interaction energy. A first-order polarization term is explicitly considered for this purpose, using standard molecular polarizabilities. Polarization appears to amount to 30–40% of the zeolite-alkane interaction energy as a consequence of the strong electric field created by the sodium cation distribution and the negatively charged framework. This approach is compared with the experimental adsorption isotherms of ethane, propane, n-octane and n-decane in NaY taken from the literature and with original measurements of n-butane isotherms in NaY obtained by thermogravimetric methods. Henry constants and heats of adsorption at zero coverage of n-alkanes (n = 6–10) have also been compared with experimental measurements. Although no specific parameter was invoked for extending the force field, general agreement between the simulation results and experiment was satisfactory. Cation redistribution upon alkane adsorption was not observed in these simulations.
Control expectancies as predictors of psychotherapy outcome: A systematic review
Authors: Delsignore Aba , Schnyder Ulrich 
Published: July 2007

Purpose Patient expectancies are known as a common factor contributing to psychotherapy outcome. Among expectancies, specific control expectancies (such as the perceived responsibility for change) can be considered of special clinical interest because of their connection with the engagement of patients in therapy. Attempts to study control beliefs in relation to psychotherapy outcome have been made by the locus of control research but received less attention in recent years. Based on findings from the expectancies literature (also including outcome and patient role expectancies), this systematic review proposes ways to reactivate the promising field of control expectancies in the psychotherapy context.Methods The PsychInfo and PubMed databases were searched with the keywords ‘expectancies’, ‘expectations’, ‘locus of control’, and ‘role expectancies’; these terms were cross‐referenced with the terms ‘patient’, ‘client’, ‘psychotherapy’, ‘treatment’, and ‘outcome’. A total of 35 studies published in the last 25 years and focusing on the relationship between patient expectancies and psychotherapy outcome were identified and included in this review.Results The review of the literature shows a modest direct relationship between specific expectancies and clinical improvement. Studies focusing on the association between global expectancies and outcome led to rather inconsistent findings.Conclusions The study of control expectancies in psychotherapy has been neglected in the past years probably due to mixed results. The main reasons for inconsistency can be found in the scarcity of specific assessment measures for treatment expectancies as well as in the limited knowledge about process variables in the past. Implications for future control expectancies research are discussed, and a new rating scale is proposed as a possible tool for measuring control expectancies in the specific context of psychotherapy.
An Apparatus to Evaluate the Pace of Baseball Field Playing Surfaces
Authors: Brosnan James T. , McNitt Andrew S. , Schlossberg Maxim J. 
Published: July 2007

Abstract
During a baseball game, the ball will strike the playing surface at a variety of speeds and angles. The speed at which the ball travels after impact with the playing surface has been referred to as the pace of the surface. Wide variations in pace can reduce the safety and playability of baseball field surfaces. Pace can be quantified by measuring the coefficient of restitution. The coefficient of restitution is defined as the ratio of two velocities; the velocity of a baseball after impact with the surface divided by the velocity of the ball prior to impact. An apparatus was developed to measure the coefficient of restitution of a baseball striking various playing surfaces. The apparatus, termed Pennbounce, uses infrared screens to measure the coefficient of restitution of baseballs propelled at varying angles and velocities. Pennbounce was used to measure the pace of traditional synthetic turf (Astroturf), infilled synthetic turf (Fieldturf), natural turfgrass, and skinned infield surfaces. Baseballs were propelled at the surfaces using two velocities and impact angles. Surface pace was highest on traditional synthetic turf, skinned infield, infilled synthetic turf, and natural turfgrass areas, respectively.