bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation hydrodynamics in a moving plasma with Compton scattering: Frequency-dependent solutions
Authors: Fukue Jun 
Published: April 2024

Abstract
Radiation hydrodynamical equations with Compton scattering are generally difficult to solve analytically, and usually examined numerically, even if in the subrelativistic regime. We examine the equations available in the subrelativistic regime of kBT$/$(mec2) ≲ 0.1, hν$/$(mec2) ≲ 0.1, and v$/$c ≲ 0.1, where T is the electron temperature, ν the photon frequency, and v the fluid bulk velocity. For simplicity, we ignore the induced scattering terms. We then seek and obtain analytical solutions of frequency-dependent radiative moment equations of a hot plasma with bulk motions for several situations in the subrelativistic regime. For example, in the static case of a plane-parallel atmosphere without bulk motions, where equations involve the generalized Kompaneets equation with subrelativistic corrections, we find the Wien-type solution, which reduces to the usual Milne–Eddington solution in the nonrelativistic limit, as well as the power-law-type one, which has a form of [hν$/$(kBT)]−4. In the moving case of an accelerating one-dimensional flow with bulk motions, we also find the Wien-type and the power-law-type solutions affected by the bulk Compton effect. Particularly, in the Wien-type solutions, due to the bulk Compton effect, the radiation fields gain momentum from the hot plasma in the low-frequency regime of hν &lt; 3kBT, while they lose it in the high-frequency regime of hν &gt; 3kBT.
Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis
Authors: Zhao Wen , Xu Fanglan , Shen Yumei , Ding Qifeng , Wang Yifei , Liang Leilei , Dai Wufei , Chen Yongbing 
Published: April 2024

Abstract
Cartilage tissue engineering offers hope for tracheal cartilage defect repair. Establishing an anti-inflammatory microenvironment stands as a prerequisite for successful tracheal cartilage restoration, especially in immunocompetent animals. Hence, scaffolds inducing an anti-inflammatory response before chondrogenesis are crucial for effectively addressing tracheal cartilage defects. Herein, we develop a shell–core structured PLGA@ICA-GT@KGN nanofilm using poly(lactic-co-glycolic acid) (PLGA) and icariin (ICA, an anti-inflammatory drug) as the shell layer and gelatin (GT) and kartogenin (KGN, a chondrogenic factor) as the core via coaxial electrospinning technology. The resultant PLGA@ICA-GT@KGN nanofilm exhibited a characteristic fibrous structure and demonstrated high biocompatibility. Notably, it showcased sustained release characteristics, releasing ICA within the initial 0 to 15 days and gradually releasing KGN between 11 and 29 days. Subsequent in vitro analysis revealed the potent anti-inflammatory capabilities of the released ICA from the shell layer, while the KGN released from the core layer effectively induced chondrogenic differentiation of bone marrow stem cells (BMSCs). Following this, the synthesized PLGA@ICA-GT@KGN nanofilms were loaded with BMSCs and stacked layer by layer, adhering to a ‘sandwich model’ to form a composite sandwich construct. This construct was then utilized to repair circular tracheal defects in a rabbit model. The sequential release of ICA and KGN facilitated by the PLGA@ICA-GT@KGN nanofilm established an anti-inflammatory microenvironment before initiating chondrogenic induction, leading to effective tracheal cartilage restoration. This study underscores the significance of shell–core structured nanofilms in temporally regulating anti-inflammation and chondrogenesis. This approach offers a novel perspective for addressing tracheal cartilage defects, potentially revolutionizing their treatment methodologies.
Gender and Parenthood Differences in Job Mobility and Pay Progression in the UK
Authors: Avram Silvia , Harkness Susan , Popova Daria 
Published: April 2024

Abstract
Understanding disparities in the rates at which men and women’s wages grow over the life course is critical to explaining the gender pay gap. Using panel data from 2009 to 2019 for the United Kingdom, we examine how differences in the rates and types of job mobility of men and women—with and without children—influence the evolution of wages. We contrast the rates and wage returns associated with different types of job moves, including moving employer for family reason, moving for wage or career-related reasons, and changing jobs but remaining with the same employer. We find important gender and parenthood differences in the types of mobility experience, with mothers most likely to switch employers for family-related reasons and least likely to move for wage or career reasons, or to change jobs with the same employer. While job changes with the same employer and career related employer changes had large positive wage returns, changing employers for family-related reasons was associated with significant wage losses. We show that differences in job mobility between mothers and other workers are largest for young employees (under 30), the period over which wages also grow most rapidly in response to career related external, or internal, job moves. These mobility differences play an important role in explaining the rapid growth in the motherhood wage gap in the years after birth.
The response of gut and fecal bacterial communities of the European sea bass (Dicentrachus labrax) fed a low fish-plant meal and yeast protein supplementation diet
Authors: Meziti Alexandra , Nikouli Eleni , Papaharisis Leonidas , Ar. Kormas Konstantinos , Mente Elena 
Published: April 2024

Abstract
As aquaculture is nowadays the major fish-food production sector, continuous research is undergoing for aquafeeds that could replace conventional fishmeal in order to enhance its environmental and economic sustainability. Fish gut microorganisms might be involved in nutrient assimilation and thus they are crucial for their hosts’ well-being. In this study, the bacterial diversity was investigated by16S rRNA gene metabarcoding in order to investigate changes in midgut (M) and feces (F) microbiota of sea bass Dicentrachus labrax fed with conventional (C) and innovative-low fish meal diet (I), aiming at discovering microbiota that could be associated with the enhancement of host's health and productivity. Our results indicated that Proteobacteria (Pseudomonadota) prevailed in all samples followed by Firmicutes (Bacillota) or Bacteroidota (mostly in feces), while fecal communities were richer. Taxonomic distributions at the operational taxonomic unit level in midgut samples revealed differentially abundant fermentative species that prevailed in individuals fed with the innovative diet. Especially Staphylococcus was more abundant in MI samples implying enhancement from ingredients present only in the innovative diet and implying that this feed shapes rather favorable microbiota, which could support the digestion and good growth performance in aquaculture.
Differences between the glans and shaft of the penis: a review
Authors: Wei Letian , Zheng Lei , Jiang Hui , Jiang Tao 
Published: April 2024

Abstract

Introduction
The penis serves as a vital receptor in men, playing a significant role in sexual intercourse. While there are discernible disparities between the glans penis and the penile shaft, a comprehensive and detailed analysis of these distinctions is currently lacking.

Objectives
This study aimed to review the existing literature on the variances between the glans penis and the penile shaft, providing a systematic examination of their anatomical and histological dissimilarities.

Methods
Our investigation encompassed a thorough search of the published literature, including original articles, reviews, letters to the editor, and case reports focused on the penis. We conducted a comprehensive review of the anatomical and histological dissimilarities between the glans penis and the penile shaft.

Results
The following key differences were identified. First, regarding innervation, the glans penis and the penile shaft possess distinct neural pathways. The glans penis exhibits a 3-dimensional structure, while the penile shaft exhibits a 2-dimensional distribution. Notably, the nerves of the penile shaft extend penetrating branches into the corpus cavernosum. Furthermore, there are variations in nerve-specific antibodies between the 2 regions. Second, regarding composition, the glans penis and the penile shaft consist of dissimilar cavernous bodies. The glans penis contains unique epithelial structures and receptors, setting it apart from the penile shaft. Third, regarding the veins, there are disparities in the venous systems of the glans penis and the penile shaft. Fourth, regarding biothesiometry, variances in biothesiometry research have been observed between the 2 regions.

Conclusion
There are differences between the glans and the shaft. To further advance our understanding, future research should delve deeper into the discrepancies between the glans penis and the penile shaft. Additionally, a more specialized subdivision of the glans penis and the penile shaft would facilitate more precise and tailored treatments.
Ameliorative anti-coagulant, anti-oxidative and anti-ferroptotic activities of nanocurcumin and donepezil on coagulation, oxidation and ferroptosis in Alzheimer’s disease
Authors: Nawar Nagat F , Beltagy Doha M , Mohamed Tarek M , Tousson Ehab , El-Keey Mai M 
Published: April 2024

Abstract
Alzheimer’s disease (ad) is a neurological condition that worsens over time and is characterized by the buildup of amyloid (Aβ) plaques in the brain parenchyma. Neuroprotection and cholinesterase inhibition have been the two primary techniques used in the creation of medications to date. In ad, a novel sort of programmed cell death known as ferroptosis takes place along with iron buildup, lipid peroxidation, and glutathione deficiency. The objective of the current investigation was to examine the neuroprotective and anti-ferroptotic role of nanocurcumin and Donepezil against model of aluminum chloride AlCl3 and D-galactose induced ad. The experiment was performed on 70 rats divided into (G1: control, G2: NCMN, G3: Donepezil, G4: ad-model, G5: Donepezil co-treatment, G6: NCMN co-treatment and G7: NCMN+Donepezil co-treatment). Hematological parameters and biochemical investigations as oxidative stress, liver function, kidney function, iron profile and plasma fibrinogen were evaluated. Treatment with Nanocurcumin alone or in combination with Donepezil improved oxidative stress, liver functions, and kidney functions, improve iron profile and decreased plasma fibrinogen.
Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function
Authors: Malany Keegan , Li Xiaohan , Vogel Christoph F A , Ehrlich Allison K 
Published: April 2024

Abstract
Macrophages play an essential role in the innate immune system by differentiating into functionally diverse subsets in order to fight infection, repair damaged tissues, and regulate inappropriate immune responses. This functional diversity stems from their ability to adapt and respond to signals in the environment, which is in part mediated through aryl hydrocarbon receptor (AHR)-signaling. AHR, an environmental sensor, can be activated by various ligands, ranging from environmental contaminants to microbially derived tryptophan metabolites. This review discusses what is currently known about how AHR-signaling influences macrophage differentiation, polarization, and function. By discussing studies that are both consistent and divergent, our goal is to highlight the need for future research on the mechanisms by which AHR acts as an immunological switch in macrophages. Ultimately, understanding the contexts in which AHR-signaling promotes and/or inhibits differentiation, proinflammatory functions, and immunoregulatory functions, will help uncover functional predictions of immunotoxicity following exposure to environmental chemicals as well as better design AHR-targeted immunotherapies.
Nerve Injury Triggers Time-dependent Activation of the Locus Coeruleus, Influencing Spontaneous Pain-like Behavior in Rats
Authors: Suárez-Pereira Irene , López-Martín Carolina , Camarena-Delgado Carmen , Llorca-Torralba Meritxell , González-Saiz Francisco , Ruiz Rocío , Santiago Martiniano , Berrocoso Esther 
Published: April 2024

Background
Dynamic changes in neuronal activity and in noradrenergic locus coeruleus (LC) projections have been proposed during the transition from acute to chronic pain. Thus, the authors explored the cellular cFos activity of the LC and its projections in conjunction with spontaneous pain-like behavior in neuropathic rats.

Methods
Tyrosine hydroxylase:Cre and wild-type Long–Evans rats, males and females, were subjected to chronic constriction injury (CCI) for 2 (short-term, CCI-ST) or 30 days (long-term, CCI-LT), evaluating cFos and Fluoro-Gold expression in the LC, and its projections to the spinal cord (SC) and rostral anterior cingulate cortex (rACC). These tests were carried out under basal conditions (unstimulated) and after noxious mechanical stimulation. LC activity was evaluated through chemogenetic and pharmacologic approaches, as were its projections, in association with spontaneous pain-like behaviors.

Results
CCI-ST enhanced basal cFos expression in the LC and in its projection to the SC, which increased further after noxious stimulation. Similar basal activation was found in the neurons projecting to the rACC, although this was not modified by stimulation. Strong basal cFos expression was found in CCI-LT, specifically in the projection to the rACC, which was again not modified by stimulation. No cFos expression was found in the CCI-LT LCipsilateral (ipsi)/contralateral (contra)→SC. Chemogenetics showed that CCI-ST is associated with greater spontaneous pain-like behavior when the LCipsi is blocked, or by selectively blocking the LCipsi→SC projection. Activation of the LCipsi or LCipsi/contra→SC dampened pain-like behavior. Moreover, Designer Receptor Exclusively Activated by Designer Drugs (DREADDs)–mediated inactivation of the CCI-ST LCipsi→rACC or CCI-LT LCipsi/contra→rACC pathway, or intra-rACC antagonism of α-adrenoreceptors, also dampens pain-like behavior.

Conclusions
In the short term, activation of the LC after CCI attenuates spontaneous pain-like behaviors via projections to the SC while increasing nociception via projections to the rACC. In the long term, only the projections from the LC to the rACC contribute to modulate pain-like behaviors in this model.

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Cost-Effectiveness of Sleeve Gastrectomy and Gastric Bypass as Revisional Surgery on Antidiabetic Reimbursement: A Nationwide Cohort Study
Authors: Thereaux Jérémie , Bennani Mohammed , Khemis Jean , Ohayon Elisabeth , Visnovec Buissez Isabelle , Lafourcade Alexandre , Quiriconi Laëtitia , Philippe Caroline , Oppert Jean-Michel 
Published: April 2024

Objective:
This study compared the effectiveness of 4 main revisional bariatric surgery (RBS) sequences after sleeve gastrectomy (SG) and adjustable gastric banding (AGB), on the reimbursement of antidiabetic treatments in France.

Background:
Few large-scale prospective cohort studies have assessed the changes in antidiabetic treatments after RBS.

Method:
This nationwide observational population-based cohort study analyzed data from the French National Health Insurance Database. All patients who underwent primary SG and AGB in France between January 2012 and December 2014 were included and followed up until December 31, 2020. The changes in categories and costs of reimbursed antidiabetic treatments across different RBS sequences were assessed (presented as follows: bariatric surgery (BS)-RBS).

Results:
Among the 107,088 patients who underwent BS, 6396 underwent RBS, 2400 SG-GBP (SG converted to gastric bypass [GBP] during follow-up), 2277 AGB-SG, 1173 AGB-GBP, and 546 SG-SG. Pre-RBS insulin was used in 10 (2.9%), 4 (0.9%), 8 (2.4%), and 10 (2.6%) patients, respectively. Two years after RBS, the treatment discontinuation or decrease (the change of treatment to a lighter one category rates [eg, insulin to bi/tritherapy]) was 47%, 47%, 49%, and 34%, respectively. Four years after RBS, the median annual cost per patient compared with baseline was lower (P < 0.01) for all sequences, except SG-SG (P = 0.24). The most notable effect concerned AGB-GBP (median of more than 220 euros to 0).

Conclusions:
This study demonstrated the positive impact of RBS over a 4-year follow-up period on antidiabetic treatments reimbursement, through the reduction or discontinuation of treatments and a significant decrease in costs per patient.
Use of Darvadstrocel (Allogenic Stem Cell Therapy) for Crohn’s Fistulas in Real Clinical Practice: The National Project to Implement Mesenchymal Stem Cell for the Treatment of Perianal Crohn’s Fistula (the PRIME Study)
Authors: Herreros Maria Dolores , Ramirez Jose-Manuel , Otero-Piñeiro Ana M. , Martí-Gallostra Marc , Badiola Izaskun , Enríquez-Navascues Jose M. , Millan Monica , Barreiro Erica , de la Portilla de Juan Fernando , Suárez Alecha Javier , Garcia-Olmo Damian ,   The National Project to Implement Mesenchymal Stem Cell for the Treatment of Perianal Crohn’s Fistula (the PRIME Study) Group
Published: April 2024

BACKGROUND:
Perianal fistulas may affect 15–50% of patients with Crohn’s disease. Treatment is complex, requiring a multidisciplinary approach. Darvadstrocel (allogenic mesenchymal cells obtained from lipoaspirates) was approved in 2018 by the European and Spanish Agencies of Medicines and Medical Products as a treatment for fistulas in Crohn’s disease. Recent European Crohn’s and Colitis Organisation and Spanish Working Group on Crohn’s Disease and Ulcerative Colitis guidelines state that darvadstrocel is effective with a favorable safety profile and a strong level of evidence (2).

OBJECTIVE:
Presenting real-world effectiveness data for darvadstrocel in a Spanish population.

DESIGN:
Observational retrospective cohort study with prospective data gathering.

SETTINGS:
Fourteen institutions.

PATIENTS:
From November 2019-April 2022, all patients (73) treated with darvadstrocel in these institutions were included, fulfilling the following criteria: 1) complex fistula/s in a patient with Crohn’s disease; 2) failure of conventional and antitumor necrosis factor treatment; 3) absence of collections >2 cm confirmed by pelvic MRI scan at the time of surgery.

INTERVENTIONS:
Darvadstrocel treatment.

MAIN OUTCOME MEASURES:
Clinical response (closure of ≥50% of external openings), complete clinical closure (100% of external openings) and radiological closure (no fluid collection >2 cm, no edema or inflammation) evaluated 6 months after treatment.

RESULTS:
Clinical response was observed in 63 patients (86.3%), complete clinical closure in 50 patients (68.5%) and radiological closure in 45 patients (69.2%). Combined clinical and radiological response was observed in 41 patients (63.1%). Not all clinically healed patients had radiological closure and vice versa. No serious adverse events were reported.

LIMITATIONS:
Retrospective.

CONCLUSIONS:
Study results were consistent with those reported in previous clinical trials, real-world efficacy findings from the INSPIRE study (assessing darvadstrocel effectiveness in Europe, Israel, Switzerland, UK, and Japan) and previously published literature. Darvadstrocel was effective and demonstrated a favorable safety profile when used in normal clinical practice for treatment of fistulas in Crohn’s disease. See Video Abstract.
Prevention and treatment of hypertensive left ventricular hypertrophy
Authors: Tatavarthy Manvita , Stathopoulos John , Oktay Ahmet Afşin 
Published: April 2024

Purpose of reviewLeft ventricular (LV) hypertrophy (LVH) is a well recognized target organ adaptation to longstanding uncontrolled hypertension and other cardiovascular risk factors. It is also a strong and independent predictor of many cardiovascular disorders.Recent findingsThis focused review explores the current concepts in screening, diagnosis, prevention, and treatment of LVH in patients with hypertension. Currently, the primary screening and diagnostic tools for LVH are ECG and 2D echocardiography. Implementing machine learning in the diagnostic modalities can improve sensitivity in the detection of LVH. Lifestyle modifications, blood pressure control with antihypertensive therapy, and management of comorbidities aid in preventing and reversing LV remodeling.SummaryLVH is a common and often silent complication of hypertension. Prevention and reversal of LV remodeling are crucial for cardiovascular risk reduction in patients with hypertension.
Current state of endothelial cell therapy
Authors: Koo Ellen H. 
Published: April 2024

Purpose of review
Currently, there is heightened interest surrounding endothelial cell therapy for the treatment of corneal edema. The purpose of this review article is to describe and summarize the background information as well as the research surrounding the emerging treatment modalities for endothelial cell therapy.

Recent findings
Marked advancements have been made in the translational research in this area, and increasing refinements have been demonstrated in the treatment protocols for cell therapy. Human clinical trials in this field are ongoing, specifically, in the area of injected human corneal endothelial cells (HCECs), with early results showing favorable safety and efficacy profiles.

Summary
Efficient and effective delivery of HCECs to patients with corneal edema and dysfunction now appears feasible, and the results from ongoing human clinical trials are much anticipated. Adjunct therapeutics—in the form of pharmacological agents and/or surgical techniques, such as descemetorhexis—will likely continue to play an important role in defining the future of endothelial cell therapy.
Legislative Health Notes: Preliminary Learnings From Piloting a New Policy Analysis Tool
Authors: Carignan Stefanie , Lindberg Ruth , Tung Gregory J. , Sullivan Jennifer , Stone Cynthia , Pollack Porter Keshia M. 
Published: April 2024

Context:
In 2018, the Health Impact Project (the Project) developed and tested a new health in all policies (HiAP) tool called “legislative health notes” to provide state and local legislators with peer-reviewed evidence, public health data, and local data that illustrate potential positive and negative health and equity effects of proposed bills.

Objectives:
The Project sought to refine the health note methodology while piloting the tool in the Colorado and Indiana General Assemblies, and with the Council of the District of Columbia, and worked with affiliates to introduce them in North Carolina, Ohio, and California.

Design and Participants:
External partners solicited feedback on health notes via semistructured interviews and surveys from legislators, legislative staff, and expert reviewers who were familiar with health notes in each of these jurisdictions.

Results:
Respondents shared that health notes were nonpartisan, were easy for nonexperts to understand, and would be more effective if delivered earlier in the legislative process.

Conclusion:
In response to informant feedback, practitioners can explore adding high-level summaries, increasing focus on health equity implications and the potential to work with legislators during the policy formulation phase. Data from this pilot suggest that legislative health notes are a promising nonpartisan and standardized tool to better understand the health and equity implications of proposed legislation.