bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome–positive leukemia
Authors: Carpenter Paul A. , Snyder David S. , Flowers Mary E. D. , Sanders Jean E. , Gooley Theodore A. , Martin Paul J. , Appelbaum Frederick R. , Radich Jerald P. 
Published: November 2006

Abstract
Relapse occurs frequently after allogeneic hematopoietic cell transplantation (HCT) for treatment of high-risk Philadelphia chromosome–positive (Ph+) leukemia. Administration of imatinib early after HCT might provide an effective approach for preventing recurrent Ph+ leukemia, but the feasibility of this approach has not been systematically tested. Twenty-two patients, 15 with Ph+ acute lymphoblastic leukemia and 7 with high-risk chronic myelogenous leukemia, were enrolled in a prospective study and given imatinib from the time of engraftment until 365 days after HCT. Before day 90, adults (n = 19) tolerated a median average daily imatinib dose of 400 mg/d (range, 200-500 mg/d), and children (n = 3) tolerated 265 mg/m2/d (range, 200-290 mg/m2/d). The most common adverse events related to imatinib administration were grade 1-3 nausea, emesis, and serum transaminase elevations. We conclude that imatinib can be safely administered early after myeloablative allogeneic HCT at a dose intensity comparable to that used in primary therapy.
Mouse models of IgG- and IgM-mediated hemolysis
Authors: Schirmer David A. , Song Shuh-Chyung , Baliff Jeffrey P. , Harbers Stephanie O. , Clynes Raphael A. , Krop-Watorek Anna , Halverson Gregory R. , Czerwinski Marcin , Spitalnik Steven L. 
Published: November 2006

AbstractWell-characterized mouse models of alloimmune antibody-mediated hemolysis would provide a valuable approach for gaining greater insight into the pathophysiology of hemolytic transfusion reactions. To this end, mouse red blood cells (mRBCs) from human glycophorin A transgenic (hGPA-Tg) donor mice were transfused into non-Tg recipients that had been passively immunized with IgG or IgM hGPA-specific monoclonal antibodies (mAbs). In this novel murine “blood group system,” mRBCs from hGPA-Tg mice are “antigen positive” and mRBCs from non-Tg mice are “antigen negative.” Passive immunization of non-Tg mice with the IgG1 10F7 and IgG3 NaM10-2H12 anti-hGPA mAbs each induced rapid clearance of incompatible transfused hGPA-Tg-mRBCs in a dose-response manner. Using various knockout mice as transfusion recipients, both the complement system and activating Fcγ receptors were found to be important in the clearance of incompatible mRBCs by each of these IgG mAbs. In addition, the IgM E4 anti-hGPA mAb induced complement-dependent intravascular hemolysis of transfused incompatible hGPA-Tg-mRBCs accompanied by gross hemoglobinuria. These initial studies validate the relevance of these new mouse models for addressing important questions in the field of transfusion medicine.
Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors
Authors: Balko Justin M , Potti Anil , Saunders Christopher , Stromberg Arnold , Haura Eric B , Black Esther P 
Published: November 2006

AbstractBackgroundIncreased focus surrounds identifying patients with advanced non-small cell lung cancer (NSCLC) who will benefit from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). EGFR mutation, gene copy number, coexpression of ErbB proteins and ligands, and epithelial to mesenchymal transition markers all correlate with EGFR TKI sensitivity, and while prediction of sensitivity using any one of the markers does identify responders, individual markers do not encompass all potential responders due to high levels of inter-patient and inter-tumor variability. We hypothesized that a multivariate predictor of EGFR TKI sensitivity based on gene expression data would offer a clinically useful method of accounting for the increased variability inherent in predicting response to EGFR TKI and for elucidation of mechanisms of aberrant EGFR signalling. Furthermore, we anticipated that this methodology would result in improved predictions compared to single parameters alone bothin vitroandin vivo.ResultsGene expression data derived from cell lines that demonstrate differential sensitivity to EGFR TKI, such as erlotinib, were used to generate models fora prioriprediction of response. The gene expression signature of EGFR TKI sensitivity displays significant biological relevance in lung cancer biology in that pertinent signalling molecules and downstream effector molecules are present in the signature. Diagonal linear discriminant analysis using this gene signature was highly effective in classifying out-of-sample cancer cell lines by sensitivity to EGFR inhibition, and was more accurate than classifying by mutational status alone. Using the same predictor, we classified human lung adenocarcinomas and captured the majority of tumors with high levels of EGFR activation as well as those harbouring activating mutations in the kinase domain. We have demonstrated that predictive models of EGFR TKI sensitivity can classify both out-of-sample cell lines and lung adenocarcinomas.ConclusionThese data suggest that multivariate predictors of response to EGFR TKI have potential for clinical use and likely provide a robust and accurate predictor of EGFR TKI sensitivity that is not achieved with single biomarkers or clinical characteristics in non-small cell lung cancers.
Possible criteria for inpatient psychiatric admissions: which patients are transferred from emergency services to inpatient psychiatric treatment?
Authors: Ziegenbein Marc , Anreis Christoph , Brüggen Bernhard , Ohlmeier Martin , Kropp Stefan 
Published: November 2006

Abstract
Background
Patients with psychiatric problems often seek help and assistance in hospital emergency departments. An important task of emergency room staff is to decide whether such patients need to be admitted or whether they can be treated on an outpatient basis.

Methods
Psychiatric treatments given in the Central Interdisciplinary Emergency Department (CED) at the Medical University of Hannover (MHH) in 2002 were analysed.

Results
Of a total of 2632 patients seeking psychiatric help, 51.4% were admitted for inpatient treatment. Patients with dementia syndromes were admitted more frequently than patients with other psychiatric diseases. Suicidality was often the reason for admission. Accompanied patients were less likely to be hospitalised, unless a care-order was in force. Restraining measures and acute medication also had an impact on the rate of admissions.

Conclusion
The results may help psychiatrists in the emergency department to make a more effective decision regarding inpatient admission in the interest of the individual patient.
Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos
Authors: Chandrakanthan Vashe , Li Aiqing , Chami Omar , O'Neill Christopher 
Published: November 2006

Abstract
In the mouse, embryo culture results in a characteristic phenotype of retarded embryo preimplantation development and reduced numbers of cells within embryos. The expression of TRP53 is central to the regulation of the cell's capacity to proliferate and survive. In this study we found that Trp53 mRNA is expressed throughout the preimplantation stage of development. Levels of TRP53 protein expression were low during the cleavage stages and increased at the morula and blastocyst stages in B6 embryos collected from the reproductive tract. Embryos collected at the zygote stage and cultured for 96 h also showed low levels of TRP53 expression at precompaction stages. There were higher levels of TRP53 in cultured morula and the level in cultured blastocysts was clearly increased above blastocysts collected directly from the uterus. Immunolocalization of TRP53 showed that its increased expression in cultured blastocysts corresponded with a marked accumulation of TRP53 within the nuclei of embryonic cells. This pattern of expression was enhanced in embryos produced by in vitro fertilization and subjected to culture. The TRP53 was transcriptionally active since culture also induced increased expression of Bax, yet this did not occur in embryos lacking Trp53 (Trp53-/-). The rate of development of Trp53-/- zygotes to the blastocyst stage was not different to wildtype controls when embryos were cultured in groups of ten but was significantly faster when cultured individually. The results show that zygote culture resulted in the accumulation of transcription activity of TRP53 in the resulting blastocysts. This accounts for the adverse effects of culture of embryos individually, but does not appear to be the sole cause of the retarded preimplantation stage growth phenotype associated with culture in vitro.
Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment
Authors: Lewis Anne M , Varghese Sheelu , Xu Hui , Alexander H Richard 
Published: November 2006

AbstractThe tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells which produce cytokines, growth factors, and adhesion molecules that promote tumor progression and metastasis. Of particular interest in this setting is interleukin-1 (IL-1), a pleiotropic cytokine with numerous roles in both physiological and pathological states. It is known to be up regulated in many tumor types and has been implicated as a factor in tumor progression via the expression of metastatic and angiogenic genes and growth factors. A number of studies have reported that high IL-1 concentrations within the tumor microenvironment are associated with a more virulent tumor phenotype. Solid tumors in which IL-1 has been shown to be up regulated include breast, colon, lung, head and neck cancers, and melanomas, and patients with IL-1 producing tumors have generally bad prognoses. The exact mechanisms by which IL-1 promotes tumor growth remain unclear, though the protein is believed to act via induction of pro-metastatic genes such as matrix metalloproteinases and through the stimulation of adjacent cells to produce angiogenic proteins and growth factors such as VEGF, IL-8, IL-6, TNFα, and TGFβ. The IL-1 receptor antagonist (IL-1ra) is a naturally occurring inhibitor to IL-1 and acts by binding to the IL-1 receptor without activating it. The protein has been shown to decrease tumor growth, angiogenesis, and metastases in murine xenograft models. Our focus in this review is to summarize the known data on the role of IL-1 in tumor progression and metastasis and the use of IL-1 inhibition as a novel therapeutic approach in the treatment of solid organ malignancies.
Clinicopathological Conference: Case Report—A Case of Anorexia and Weak Arm
Authors: Wiler Jennifer L. , Bailey Heatherlee 
Published: November 2006

AbstractThe authors present the case of a 49‐year‐old female who presented to the emergency department with a chief complaint of “not eating well.” She was found to have a heart murmur, a focal neurological deficit, and large mitral valve vegetation. The patient was later diagnosed with acute Pseudomonal endocarditis with septic emboli to the brain, liver, spleen, and kidneys. A discussion of the patient presentation, diagnostic evaluation, and outcome are reviewed.
Mapping Quantitative Trait Loci Using the Experimental Designs of Recombinant Inbred Populations
Authors: Kao Chen-Hung 
Published: November 2006

AbstractIn the data collection of the QTL experiments using recombinant inbred (RI) populations, when individuals are genotyped for markers in a population, the trait values (phenotypes) can be obtained from the genotyped individuals (from the same population) or from some progeny of the genotyped individuals (from the different populations). Let Fu be the genotyped population and Fv (v ≥ u) be the phenotyped population. The experimental designs that both marker genotypes and phenotypes are recorded on the same populations can be denoted as (Fu/Fv, u = v) designs and that genotypes and phenotypes are obtained from the different populations can be denoted as (Fu/Fv, v &gt; u) designs. Although most of the QTL mapping experiments have been conducted on the backcross and F2(F2/F2) designs, the other (Fu/Fv, v ≥ u) designs are also very popular. The great benefits of using the other (Fu/Fv, v ≥ u) designs in QTL mapping include reducing cost and environmental variance by phenotyping several progeny for the genotyped individuals and taking advantages of the changes in population structures of other RI populations. Current QTL mapping methods including those for the (Fu/Fv, u = v) designs, mostly for the backcross or F2/F2 design, and for the F2/F3 design based on a one-QTL model are inadequate for the investigation of the mapping properties in the (Fu/Fv, u ≤ v) designs, and they can be problematic due to ignoring their differences in population structures. In this article, a statistical method considering the differences in population structures between different RI populations is proposed on the basis of a multiple-QTL model to map for QTL in different (Fu/Fv, v ≥ u) designs. In addition, the QTL mapping properties of the proposed and approximate methods in different designs are discussed. Simulations were performed to evaluate the performance of the proposed and approximate methods. The proposed method is proven to be able to correct the problems of the approximate and current methods for improving the resolution of genetic architecture of quantitative traits and can serve as an effective tool to explore the QTL mapping study in the system of RI populations.
The Power of Legitimacy and the Legitimacy of Power: International Law in an Age of Power Disequilibrium
Authors: Franck Thomas M. 
Published: November 2006

The American Society of International Law (ASIL), incorporated by Act of Congress in 1950, was founded in 1906 “to promote the establishment and maintenance of international relations on the basis of law and justice.” As we celebrate the centennial of this, the Society’s principal publication, it is appropriate to examine the present and future prospects of this project. Is it still a compelling aspiration in the era of U.S. superpower-dom?The founding of the Society and initiation of the Journal (AJIL) must be seen in the context of the then-prevalent American commitment to the idea that a world of international law and international tribunals would be a natural, even historically inevitable, extrapolation of a good American idea. Speaking in 1890 to the first Pan-American Conference, President Benjamin Harrison congratulated the delegates on formulating a hemispheric arbitration agreement. “We rejoice,” he said, “that you have found in the organization of our Government something suggestive and worthy of imitation.” At The Hague in 1907, Secretary of State Elihu Root, the founding president of the ASIL, called for the creation of an international court “which would pass upon questions between nations with the same impartial and impersonal judgment that the Supreme Court of the United States gives to questions arising between citizens of the different States.”
Uniform stochastic ordering and related inequalities
Authors: Keilson Julian , Sumita Ushio 
Published: November 2006

AbstractStochastic order between univariate random variates may be called uniform when such order persists under conditioning to a broad family of intervals. The ordering is local when it holds for any finite interval (a, b), however small. Local order in multivariate settings has been described by Whitt (1980, 1981), by Karlin and Rinott (1980), and by others. The prevalence of uniform and local order in a variety of simple stochastic‐process settings is displayed, and inequalities arising from such orderings developed.
An explicit formula for the risk of James‐Stein estimators
Authors: Egerton M. F. , Laycock P. J. 
Published: November 2006

AbstractExpressions for the risk of a Stein estimator and its principal derivatives involve a well‐defined. but nonevaluated. expectation term. Stein (1966) has suggested a second‐order approximation. In this paper we present an alternative exact expression.
Shortest confidence and prediction intervals for the log‐normal
Authors: Dahiya Ram C. , Guttman Irwin 
Published: November 2006

AbstractWe provide the shortest prediction interval forX, and the shortest confidence interval for the median ofX, whenXhas the log‐normal distribution for both the case σ2, the variance of logX, known and unknown. Tables are given to assist the practitioner in constructing these intervals. A real‐life example is provided to illustrate the results.
Matthew Arnold and Science
Authors: Dudley Fred A. 
Published: November 2006

The central axiom of Mathew Arnold's cultural arithmetic is well known; less familiar is this curiously precise elaboration:And, as the discipline of conduct is three-fourths of life, for our aesthetic and intellectual disciplines, real as these are, there is but one-fourth of life left; and if we let art and science divide this one-fourth fairly between them, they will have just one-eighth of life each.
Structure and morphology of polyethylene/polypropylene in‐reactor alloys synthesized by spherical high‐yield Ziegler–Natta catalyst
Authors: Fu Zhisheng , Zhang Yanzhong , Fan Zhiqiang , Xu Junting 
Published: November 2006

AbstractA series of spherical polyethylene/polypropylene (PE/PP) in‐reactor alloys were synthesized with spherical high‐yield Ziegler–Natta catalyst by sequential multistage polymerization in slurry. The morphology of PE/PP alloy granule was evaluated by optical microscopy, scanning electron microscopy, and transmission electron microscopy. The results show PE/PP in‐reactor alloy with excellent morphology, high porosity, and narrow distribution of the particle size. The PE/PP in‐reactor alloys show excellent mechanical properties with good balance between toughness and rigidity. It was fractionated into five fractions by temperature‐gradient extraction fractionation, and every fractionation was analyzed by FTIR, 13C‐NMR, DSC, and WAXD. The PE/PP in‐reactor alloy was found to contain mainly five portions: PP, PE, segmented copolymer with PP and PE segment of different length, ethylene‐b‐propylene copolymer, and an ethylene–propylene random copolymer. The characteristic chain structure leads to good compatibility between the fractions of the alloy that shows a multiphase structure. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2075–2085, 2007
Numerical simulation of reactive extrusion processes of PA6
Authors: Wu Lili , Jia Yuxi , Sun Sheng , Zhang Guofang , Zhao Guoqun , An Lijia 
Published: November 2006

AbstractTo analyze the complicated relationships among the variables during the reactive extrusion process of polyamide 6 (PA6), and then control the chemical reaction and the material structures, the process of continuous polymerization of caprolactam into PA6 in a closely intermeshing co‐rotating twin screw extruder was simulated by means of the finite volume method, and the influences of three key processing parameters on the reactive extrusion process were discussed. The simulated results of an example were in good agreement with the experimental results. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2331–2336, 2007
Influence of grafted polypropylene on the mechanical properties of mineral‐filled polypropylene composites
Authors: Toro Patricio , Quijada Raúl , Peralta Ronald , Yazdani‐Pedram Mehrdad 
Published: November 2006

AbstractThe purpose of this work was to study how mineral fillers would behave in a polypropylene (PP) matrix when PP modified with maleic anhydride (MA) and/or itaconic acid (IA) was used as a coupling agent in the preparation of mineral‐filled PP composites. The composites were characterized with tensile mechanical measurements and morphological analysis. The optimum amount of the coupling agent to be used to obtain composites with improved mechanical properties was established. The results indicated that these coupling agents enhanced the tensile strength of the composites significantly, and the extent of the coupling effect depended on the nature of the interface that formed. The incorporation of coupling agents enhanced the resistance to deformation of the composite. The behavior of IA‐modified PP as a coupling agent was similar to that of a commercial MA‐modified PP for the filled PP composites. Evidence of improved interfacial bonding was revealed by scanning electron microscopy studies, which examined the surfaces of fractured tensile test specimens; their microstructures confirmed the mechanical results with respect to the observed homogeneous or optimized dispersion of the mineral‐filler phase in these composites. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2343–2350, 2007
Investigation of conductivity characteristics of nitrile butadiene rubber vulcanizates filled with semiconducting carbide ceramic
Authors: Todorova Z. , El‐Tantawy F. , Dishovsky N. , Dimitrov R. 
Published: November 2006

AbstractSiC‐ and B4C‐filled NBR rubber composites were prepared with various volume fractions of filler by a conventional roll‐mill method. The morphological structures of the NBR–SiC and NBR–B4C composites were analyzed by scanning electron microscopy. The dependence of room‐temperature volume resistivity (ρv) on the concentration of filler in the two systems was studied. In addition, variation in the number of current carriers (n), mobility carriers (μ), dielectric constant (ε), and dielectric loss factor (tan δ) on filler concentration in the two systems were investigated in detail. The applicability of composites as negative temperature coefficient (NTCR) linear thermistors was studied by the dependence of volume resistivity on temperature. The resistivity showed negative temperature dependence and changed linearly with temperature parallel. The conduction mechanism of the conductivity of the two composites was analyzed in terms of the computed activation energy and hopping energy. Change in volume resistivity as a function of frequency for the two systems was also investigated. Finally, the dependence of volume resistivity on applied pressure and possible real applications of these composites as transducers in pressure sensors were also studied. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2158–2165, 2007
Diffusion properties of reactive dyes into net modified cotton cellulose with triazine derivative
Authors: Xie Kongliang , Sun Yan , Hou Aiqin 
Published: November 2006

AbstractCotton fabric is chemically modified with a 1,3,5‐triazine derivative containing multireactive and multicationic groups. The diffusion properties of the reactive dyes into net modified cotton cellulose are investigated. When the dyeing temperature is raised, the dye uptake increases gradually and approaches equilibrium after dyeing for 60 min. The diffusion coefficients at different temperatures and the activation energy of the dye are discussed. Compared with unmodified cellulose, the diffusion kinetics of the dye in the net modified cotton cellulose show significant changes. The activation energies of dyes in net modified cotton fibers are much lower than those of dyes in unmodified cotton. The dyeing behavior of the modified cotton is analyzed and compared with the unmodified cotton. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2166–2171, 2007