bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smartphone‐delivered approach bias modification for reducing harmful drinking amongst middle–older age adults: Secondary analyses of a single‐arm pilot study
Authors: Bolt Georgia L. , Piercy Hugh , Bradshaw Jennifer , Manning Victoria 
Published: March 2024

AbstractIntroductionNovel, scalable, low‐cost interventions are needed to reduce harmful drinking amongst middle–older adults. Approach bias modification (ApBM) is a promising form of cognitive training for preventing/reducing alcohol use that can be delivered via smartphone. This study explored the acceptability and preliminary effectiveness of smartphone delivered and personalised ApBM amongst Australians ≥55 years, an age cohort at risk of alcohol‐related harms.MethodsSecondary analyses in a middle–older adult subsample (≥55 years, n = 289) of an open‐label pilot study using a retrospective, repeated measures design. We explored acceptability (adherence, user mobile acceptability ratings, free‐text responses) and preliminary effectiveness (changes in drinking quantity and frequency, craving, dependence and proportion drinking within government‐recommended guidelines) of two sessions/week over 4 weeks of evidence‐based ApBM training, adapted to include personalisation and smartphone delivery amongst Australians ≥55 years.ResultsAlthough minor adaptations to training were suggested, the intervention was acceptable amongst survey completers, with 72% training adherence. Relative to baseline, there was a significant increase in the proportion of drinking within recommended single‐session and weekly guidelines post‐training (from 25% to 41% and 6% to 28%, respectively, p < 0.001), with past‐week standard drinks significantly decreasing by 18% (p < 0.001) and significant reductions in drinking days, mean craving and dependence scores (p < 0.001).Discussion and ConclusionsFindings suggest smartphone ApBM is acceptable amongst middle‐to‐older aged Australians and may support this ‘at risk’ cohort to remain within government‐recommended alcohol consumption guidelines to optimise healthy aging, although, in the context of a single‐arm study, preliminary results should be interpreted cautiously.
Evaluation of mortality, prognostic parameters, and treatment efficacy in mycosis fungoides
Authors: Porkert Stefanie , Griss Johannes , Hudelist‐Venz Mercedes , Steiner Irene , Valencak Julia , Weninger Wolfgang , Brunner Patrick M. , Jonak Constanze 
Published: March 2024

SummaryBackground and ObjectivesMycosis fungoides (MF), the most common primary cutaneous T‐cell lymphoma, is characterized by a variable clinical course, presenting either as indolent disease or showing fatal progression due to extracutaneous involvement. Importantly, the lack of prognostic models and predominantly palliative therapy settings hamper patient care. Here, we aimed to define survival rates, disease prediction accuracy, and treatment impact in MF.Patients and methodsHundred‐forty MF patients were assessed retrospectively. Prognosis and disease progression/survival were analyzed using univariate Cox proportional hazards regression model and Kaplan‐Meier estimates.ResultsSkin tumors were linked to shorter progression‐free, overall survival and a 3.48 increased risk for disease progression when compared to erythroderma. The Cutaneous Lymphoma International Prognostic Index identified patients at risk in early‐stage disease only. Moreover, expression of Ki‐67 >20%, CD30 >10%, CD20+, and CD7– were associated with a significantly worse outcome independent of disease stage. Only single‐agent interferon‐α and phototherapy combined with interferon‐α or retinoids/bexarotene achieved long‐term disease control in MF.ConclusionsOur data support predictive validity of prognostic factors and models in MF and identified further potential parameters associated with poor survival. Prospective studies on prognostic indices across disease stages and treatment modalities are needed to predict and improve survival.
Luther's interpretation of communicatio idiomatum in a new key
Authors: Pedersen Else Marie Wiberg 
Published: March 2024

AbstractInto the debates about Christ's two natures, divine and human, and how they relate, Martin Luther threw his extended interpretation of the communicatio idiomatum, the communication of the person Christ's attributes. Luther's Christology is incarnational and it is fundamental to him that God can and will be known only as a human being (homo/Mensch), yet Christ's real presence is presented three dimensionally and in bodily intersectionality. Luther's complex understanding of Christ as really human and the Word incarnate is reflected in his intense work with the sacraments as well as with semantics and the art of translation. Luther aims at an inclusive Christology, sacramentology, and language. Hence Christ is human, not male; sacraments are seen as direct exchange between God and humans in the body of Christ; and ministry is reconfigured as a human function of preaching the Word (ministerium verbi), not a substitute representing divine sacredness.
Blaming the dead
Authors: Jefferson Anneli 
Published: March 2024

AbstractShould moral blame stop at the grave? We often blame the dead for the bad things they did while alive. But blaming the dead poses a prima facie challenge to accounts which take our blaming practices to aim at communicating moral disapproval to wrongdoers or at improving their moral agency. If these kinds of aims are made definitional for blame, blaming the dead becomes impossible. But even on accounts which say that paradigmatically, blame is a form of moral engagement which aims to effect changes in the wrongdoer, blaming the dead may seem unjustified, pointless or even irrational. In this paper, I explain how blaming the dead can be made sense of and justified. However, not all cases of blaming the dead fit this explanation, because blaming the dead is not a homogenous practice.
Disentangling the variability of symbiotic nitrogen fixation rate and the controlling factors
Authors: Yao Yanzhong , Han Bingbing , Dong Xunzhuo , Zhong Yunyao , Niu Shuli , Chen Xinping , Li Zhaolei 
Published: March 2024

AbstractSymbiotic nitrogen (N) fixation (SNF), replenishing bioavailable N for terrestrial ecosystems, exerts decisive roles in N cycling and gross primary production. Nevertheless, it remains unclear what determines the variability of SNF rate, which retards the accurate prediction for global N fixation in earth system models. This study synthesized 1230 isotopic observations to elucidate the governing factors underlying the variability of SNF rate. The SNF rates varied significantly from 3.69 to 12.54 g N m−2 year−1 across host plant taxa. The traits of host plant (e.g. biomass characteristics and taxa) far outweighed soil properties and climatic factors in explaining the variations of SNF rate, accounting for 79.0% of total relative importance. Furthermore, annual SNF yield contributed to more than half of N uptake for host plants, which was consistent across different ecosystem types. This study highlights that the biotic factors, especially host plant traits (e.g. biomass characteristics and taxa), play overriding roles in determining SNF rate compared with soil properties. The suite of parameters for SNF lends support to improve N fixation module in earth system models that can provide more confidence in predicting bioavailable N changes in terrestrial ecosystems.
Effects of thumb‐tack needling combined with sporting on older adult patients with knee osteoarthritis: A randomized active‐control clinical trial
Authors: Wang Qiaoling , Cai Genghui , Lu Tianxiang , Fu Xiaofen , Peng Le 
Published: March 2024

AimThe aim of this clinical study was to explore the effects of thumb‐tack needling combined with sporting (TTNS) therapy on the improvement of pain and joint function in older adult patients with knee osteoarthritis (KOA).MethodsA total of 120 older adult patients with KOA were randomly assigned to receive TTNS therapy or medicine treatment (Med group) only for 1 month. The patients were followed up for 3 months and clinical efficacies were evaluated using a visual analog scale to assess pain, the Lequesne scoring system to assess motor function, and the Western Ontario and McMaster University Osteoarthritis Index to assess KOA severity. Blood was collected to measure the levels of interleukin‐6 and tumor necrotic factor‐alpha using enzyme‐linked immunosorbent assay.ResultsThe data suggested that TTNS therapy resulted in a significantly higher clinical efficacy (P = 0.012). Visual analog scale score, Lequesne index, and Western Ontario and McMaster University Osteoarthritis Index of the TTNS group at the time of post‐treatment (1 month) and post‐follow‐up (3 months) were also lower compared with the Med group. Patients in the TTNS group also showed lower levels of serum tumor necrotic factor‐alpha and interleukin‐6.ConclusionsTTNS therapy is more efficacious than pharmacological treatment in improving the clinical outcomes of patients with KOA, which suggests its clinical utility in the management of KOA. Geriatr Gerontol Int 2024; 24: 415–420.
Meta‐analysis of Helicobacter pylori eradication therapy using vonoprazan as an acid suppressor compared with bismuth quadruple therapy
Authors: Yang Hui , Zhang Miao , Ma Gang , Yang Jiaqi , Wang Kemei , Jiang Shuangshuang , Dong Jiaqiang , Han Ying 
Published: March 2024

AbstractBackgroundVonoprazan, a novel acid suppressant, has recently emerged as a regimen for eradicating Helicobacter pylori. However, uncertainties exist about the effectiveness and safety of VPZ‐based regimens compared with those of bismuth‐based quadruple therapy in eradicating H. pylori. The present meta‐analysis was performed to compare the effectiveness and safety of vonoprazan‐based regimens with those of bismuth quadruple therapy in eradicating H. pylori.Materials and MethodsAll randomized controlled trials and non‐randomized controlled trials comparing the vonoprazan‐based therapy with the bismuth quadruple therapy were included in this meta‐analysis. Information was also extracted by two evaluators, and if heterogeneity existed, a random‐effects model was used to calculate the combined relative ratio and 95% confidence interval; otherwise, a fixed‐effects model was used. And subgroup analyses were performed to explore the sources of heterogeneity.ResultsA total of 10 studies, comprising 2587 patients were included in the meta‐analysis. The results showed that the combined eradication rate of patients treated with the vonoprazan‐based regimen was significantly higher than that of patients treated with bismuth quadruple therapy, in both intention‐to‐treat and per‐protocol analyses, and the differences were statistically significant. Among the intention‐to‐treat analyses results: (90.28% vs. 83.64% [odds ratio (OR) = 1.85, 95% confidence interval (CI) (1.27, 2.70), p = 0.001]); in the per‐protocol analyses: (94.80% vs. 89.88%, [OR = 2.25, 95% CI (1.37, 3.69), p = 0.001]). The occurrence of adverse events was significantly lower in patients treated with vonoprazan‐based regimens than in those treated with bismuth quadruple therapy, (14.50% vs. 25.89%, [OR = 0.49, 95% CI (0.32, 0.75), p = 0.001]).ConclusionsFor eradicating H. pylori, vonoprazan‐based regimens are remarkably advantageous over bismuth quadruple therapy. Furthermore, vonoprazan‐based regimens exhibit a lower rate of adverse events than bismuth quadruple therapy.
Patient and public involvement in the development of the digital tool MyBoT to support communication between young people with a chronic condition and care providers
Authors: van Schelven Femke , van Weele Mara , van der Meulen Eline , Wessels Elise , Boeije Hennie 
Published: March 2024

AbstractIntroductionTo guide good practices in patient and public involvement (PPI), several calls have been made to share detailed accounts of practical experiences. We describe our collaboration with young people with a chronic condition (YPCC) in the development, testing and implementation of the digital communication tool MyBoT (Map your Burden of Treatment).MethodsMyBoT was developed by a team of academic researchers, some of whom were practising care providers, YPCC and designers. In addition to the two co‐researchers in the research team, various groups of YPCC were involved in decision‐making through participation in a design session, workshops and a dialogue session. The Involvement Matrix was used to reflect on the PPI of all YPCC.ResultsInitially, the two co‐researchers were involved in the roles of informer and co‐thinker, but their decision‐making power within the study increased over time. In the final stages of the study, the co‐researchers and researchers became partners. The other YPCC who participated in the different sessions and workshops were co‐thinkers in all stages of the study.ConclusionThe PPI of two YPCCs as co‐researchers within the research team ensured continuous involvement, whereas the PPI of various groups of YPCCs guaranteed a representative and inclusive approach. Researchers play an essential role in bringing all perspectives together, integrating them within the technical and financial constraints and ultimately building a tool that is tailored to its users' needs.Patient or Public ContributionYPCC played a significant role in the present study. Two YPCC—who are also co‐authors of this paper—were involved in all stages of this project as members of the research team. In addition, various YPCCs were involved in the development, testing and implementation stage of MyBoT by organizing design sessions, workshops and a dialogue session.
Effect of storage conditions and packaging on the quality of flaxseed in Chinese dried noodles during long‐term storage
Authors: Duan Yiting , Xie Xiaoqing , Kang Dan , Li Qi , Gao Yuan , Zhang Siyu , Yu Xiuzhu 
Published: March 2024

SummaryIn this study, Chinese dried noodles (CHDNs) were fortified with unhulled flaxseed flour (UHFF) and hulled flaxseed flour (HFF). The effects on texture properties and antioxidant activity during different storage conditions were investigated. The quality of wheat noodles can be significantly enhanced when UHFF and HFF were determined as 5% and 10%, respectively. During storage under various conditions for 60 days, the hardness, chewiness, total phenolic content (TPC) and antioxidant activity of the CHDNs gradually decreased over time. However, the resistance and extensibility initially increased and then declined in semi‐closed packaging storage under accelerated conditions. Antioxidant activity was found to have significant correlations with texture, packaging of flaxseed CHDNs during storage. In general, fully closed‐packaging CHDNs should be stored at room temperature; flaxseed CHDNs in semi‐closed packaging are recommended to be stored in cold storage, which is conducive to maintaining their texture and antioxidant activity.
Maternal‐driven immune education in offspring
Authors: Fernandes Krist Antunes , Lim Ai Ing 
Published: March 2024

SummaryMaternal environmental exposures, particularly during gestation and lactation, significantly influence the immunological development and long‐term immunity of offspring. Mammalian immune systems develop through crucial inputs from the environment, beginning in utero and continuing after birth. These critical developmental windows are essential for proper immune system development and, once closed, may not be reopened. This review focuses on the mechanisms by which maternal exposures, particularly to pathogens, diet, and microbiota, impact offspring immunity. Mechanisms driving maternal‐offspring immune crosstalk include transfer of maternal antibodies, changes in the maternal microbiome and microbiota‐derived metabolites, and transfer of immune cells and cytokines via the placenta and breastfeeding. We further discuss the role of transient maternal infections, which are common during pregnancy, in providing tissue‐specific immune education to offspring. We propose a “maternal‐driven immune education” hypothesis, which suggests that offspring can use maternal encounters that occur during a critical developmental window to develop optimal immune fitness against infection and inflammation.
BAUSTEIN—A design tool for configuring and representing design research
Authors: Schoormann Thorsten , Möller Frederik , Chandra Kruse Leona , Otto Boris 
Published: March 2024

AbstractToday's Information Systems (IS) design research projects pursue digital innovation to conquer complex societal challenges. Many of these projects reach out beyond disciplinary and organisational boundaries, as evident in interdisciplinary consortia and academia‐industry collaboration. The design activities in each project differ based on contextual requirements and the team's underlying design logic. As diversity increases, shared understanding is essential for project success. Established design research methodologies need complementary tools to support design researchers in configuring their design activities and representing them faithfully, dimensions that contribute to a shared understanding. This article presents Baustein as an instance of such design tools. Baustein is tailorable to the contextual requirements of each design research project, comprising an ensemble of card‐deck, ready‐made configurations, and a manual. To ensure theoretical and practical relevance, the design of Baustein is based on primary empirical data (workshop and interviews with 16 IS design researchers) and a literature analysis of 99 published IS design research projects. We demonstrate its proof‐of‐value through three main evaluation episodes, altogether involving over 110 IS design researchers. With Baustein, design research teams can balance the trade‐off between creative messiness and standardised configurations of design activities.
Evaluating the role of wound‐healing genes in conjunction with stool routine and serum tumor markers for colorectal cancer diagnosis and prognostic implications
Authors: Yu Kunze , Fang Xing 
Published: March 2024

AbstractColorectal cancer is a common malignant digestive tract tumour with high morbidity and mortality. Early detection, treatment and diagnosis are crucial for preventing and treating colorectal cancer, which develops through multi‐stage accumulation and gene participation, affecting tumour marker levels. Chronic wounds can lead to the development of certain cancers, such as colorectal cancer. The prolonged inflammation and tissue repair caused by chronic wounds can trigger cellular changes, potentially promoting cancerous cell growth in the colon. The formation and progression of colorectal cancer involve changes in tumour markers, such as carcinoembryonic antigen (CEA), sugar chain antigen 19–9 (CA199) and CA125. This study explores the clinical application value of a stool routine combined with serum tumour marker detection in diagnosing colorectal cancer. The experiment team examined the clinical information of 56 colorectal cancer patients alongside a control group of 56 healthy patients. Distinct stool characteristics and heightened occult blood rates were evident in colorectal cancer cases. The combined approach integrating stool routine and serum tumour markers improved diagnostic accuracy, displaying enhanced sensitivity and specificity compared with individual markers or stool routines alone. Bioinformatics analysis indicated increased CEA and CA125 levels in colorectal cancer tissues versus normal tissues, hinting at potential prognostic implications. Exploring wound‐healing genes like Vascular Endothelial Growth Factor A (VEGFA), Tumour Protein 53 (TP53) and Transforming Growth Factor Alpha (TGFA) revealed heightened expression in colorectal cancer, suggesting their potential role in disease progression. These markers showed associations with various immune cell types, suggesting their impact within the tumour microenvironment (p < 0.05). Single‐cell RNA sequencing data highlighted varying CEA expressions across different cell populations in colorectal cancer. The findings indicated that integrating clinical assessments with accurate biomarkers may provide valuable insights into prognostic implications.
The impact of glucocorticoids therapy on cutaneous wounds in Kawasaki disease: A meta‐analysis of randomized controlled trials
Authors: Hu Jian , Gao Lichao , Fu Songling , Wang Wei , Xie Chunhong , Zhang Yiying , Ke Haiyan , Gong Fangqi 
Published: March 2024

AbstractKawasaki disease (KD) is one of the most challenging diseases that is defined as an acute vasculitis that affects the coronary arteries primarily in children. It causes complications if left untreated at early stages, ultimately leading to death. Corticosteroids have been recognized to treat and cause great impact on the patients with KD. Glucocorticoid is one of the main corticosteroids that are being used to treat KD and cutaneous wounds. However, ineffectiveness of a few glucocorticoids can limit the efficacy of this treatment. This study particularly aimed to elucidate the impact of glucocorticoids on cutaneous wounds in KD. To perform the meta‐analysis, a comprehensive literature survey was conducted to unveil the studies and research conducted on Kawasaki patients that revealed different glucocorticoids in the form of specific interventions influencing KD. The literature was searched using numerous keywords, screened and data was extracted to perform the meta‐analysis and then it was conducted using the metabin function of R package meta. A total of 2000 patients from both intervention and control groups were employed to carry out the meta‐analysis to analyse and evaluate the impact of glucocorticoids on curing KD and cutaneous wounds in patients. The results disclosed that glucocorticoids along with other steroids, mainly IVIG (intravenous immunoglobulin), was an effective intervention to patients suffering from Kawasaki. The results depicted significant outcomes with the values (risk ratio [RR]: 1.08, 95% confidence interval [CI]: 0.58–2.00, p < 0.01) and enlightened the fact that adopting different glucocorticoids may significantly improve the efficacy of skin lesions along with KD. Hence, interventions of glucocorticoids must be utilized in the clinical practice to reduce the incidence of skin wounds and adverse effects caused due to KD.
Kurt Rowland's Visual Education: A Quiet Force in Post‐War Art Pedagogy
Authors: Goodwin Donna , Uhrmacher P. Bruce 
Published: March 2024

AbstractThis paper introduces the life and work of art educator and designer Kurt Rowland (1920–1980) who authored the first set of textbooks on visual education and played a role in the shifting world of art and design education in post‐war Britian. We detail the foundational experiences of his extraordinary life in the first half of the 20th century including surviving the Spanish Civil War and La Retirada, being a ‘friendly enemy alien’, and becoming one of the Dunera boys forced into Australian internment camps. He later went on to develop a new aspect of art and design education he called visual education. We explore Rowland's notion of a visual education, explicating its features, appraising its import, and situating Rowland's ideas to those of his contemporaries. We explore his motivations and how his work advanced art pedagogy. Finally, we argue that Kurt Rowland has been absent in recent literature on art and design education and that his work, which contains elements that have continued relevance today, should not be overlooked.