bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensor‐enabled Orthopedic Implants for Musculoskeletal Monitoring
Authors: Huang Jincai , Dong Hanqing , Zhang Wanmei , Cui Jixin , Li Qingang , Wang Junqiang , Zhao Zhe , Zang Xining 
Published: February 2025

AbstractNext‐generation smart implants, in addition to providing essential mechanical and physiological functions, can self‐monitor, assess bone tissue health, and enable personalized treatment customization. However, integrating traditional orthopedic implants with sensing technologies and their clinical translation remain significant challenges due to stringent implantation requirements and the harsh biological environment. This article emphasizes the importance of biomechanical monitoring and reviews key strategies for integrating sensors with orthopedic implants. Furthermore, this work outlines specific research directions and future perspectives for this rapidly evolving field. Through interdisciplinary design and optimization of key components, these smart implants’ transdermal and transmuscular sensing and communication capabilities are expected to become more efficient and robust, ensuring the technological foundation for successful clinical translation.
Bio‐Inspired Advanced Warehouse System for Data Handling and Management
Authors: Kalluru Sohit Reddy , Reddy Gurijala Prasanna Kumar , Reddy Puli Venkata Obula , Kalluru Lohit Reddy 
Published: February 2025

AbstractBig data analytics involves gathering data in a variety of forms and sources cleaning it up, customizing it, and then loading it into a data warehouse. Transformation algorithms are required for processing but this raises computation costs because it is stored across all locations in the data warehouse and has redundancy issues. Therefore, Extract, Transform, Load (ETL) is crucial to extract the data from various sources, transform it to meet analytical needs, and load it into a data warehouse. Hence, a novel Chimp‐based K‐means Tabu Warehouse System (CbKTWS) is proposed to handle large data in an ETL process based on cloud architecture. The key novelty of this work is managing the data resources in the data warehouse system with the help of chimp fitness. Moreover, the data is extracted using the chimp optimization's searching function and significant dimensional elimination of the information is executed by employing the habits created by a chimp optimizer during the transformation phase of the ETL process. Finally, the taboo search with the k‐means technique is used to create efficient data with a variety of nodes. Ultimately, the effectiveness of the suggested approach is assessed and contrasted with the earlier approaches using metrics like error, data accuracy, and processing time.
Ribonuclease 1 Induces T‐Cell Dysfunction and Impairs CD8+ T‐Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1
Authors: Yang Wen‐Hao , Huang Bao‐Yue , Rao Hsing‐Yu , Ye Peng , Chen Bi , Wang Hao‐Ching , Chung Chih‐Hung , Wu Heng‐Hsiung , Yen Hung‐Rong , Wang Shao‐Chun , Cha Jong‐Ho , Yan Xiuwen , Yang Muh‐Hwa , Hung Mien‐Chie 
Published: February 2025

AbstractT‐cell‐based immunotherapy holds promise for eliminating cancer through T‐cell activation. However, prolonged interaction between T cells and tumors and the presence of immunosuppressive factors can diminish T‐cell cytotoxicity, leading to treatment failure. Here, ribonuclease 1 (RNase1), which degrades RNA, reduced the expression of effector cytokines and increases immune checkpoint protein levels, inducing T‐cell dysfunction. RNase1 expression is positively associated with exhausted T‐cell gene signatures and immune checkpoint proteins across several cancer types. Cancer cells expressing RNase1 are resistant to CD8+ T‐cell‐mediated killing. RNase1 promotes tumor growth in immunocompetent, but not in immunodeficient, mouse models and inhibits CD8+ T‐cell activity in vivo. Mechanistically, RNase1 enters T cells and deactivates signal transducer and activator of transcription 1 (STAT1), causing T‐cell dysfunction. Loss of RNase1‐STAT1 interaction restores CD8+ T‐cell cytotoxicity. Notably, a study has found RNase1 might activate CD4+ T cells to inhibit breast cancer growth, while another has indicated it causes immunosuppression in liver cancer. The current research shows that RNase1 does not impact CD4+ T cells in vivo. Overall, the study supports the immunosuppressive role of RNase1 in cancer of negatively regulating STAT1 to impair CD8+ T‐cell cytotoxicity. Targeting the RNase1‐STAT1 interaction could prevent CD8+ T‐cell dysfunction in RNase1‐highly expressing cancer patients.
Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type‐Specific Cells
Authors: Pan Yizhen , Wang Zhuonan , Zhang Xiang , Zhao Wenpu , Zhang Haonan , Li Xuan , Jia Xiaoyan , Ji Qiuyu , Yin Bo , Bai Guanghui , Wu Tingting , Lee Zhiqi , Ding Jierui , Shi Lei , Zhang Jie , Salat David H. , Bai Lijun 
Published: February 2025

AbstractThe heterogeneous injuries and resulting cognitive deficits pose significant challenges in the clinical management of mild traumatic brain injury (mTBI). However, the pathophysiological mechanisms related to heterogeneities of mTBI are still unclear. This study aims to explore the mechanisms underlying brain remodeling by examining the morphometric similarity (MS) alterations and corresponding transcriptomic signatures across adult and pediatric mTBI (adult mTBI: 112 acute patients, 47 follow‐up chronic patients, 66 healthy controls [HCs]; pediatric mTBI: 30 acute patients, 31 HCs). A healthy adult cohort (N = 840) is included to derive the modularized brain MS networks representing interregional cortical connectivity. Subsequently, cortical MS remodeling patterns are identified involving mostly MS increases in the frontal modules with typical high MS and decreases in the occipital module with typical low MS, with more pronounced changes observed in the developing brain with mTBI. The abnormal MS changes are correlated with variable cognitive impairments. Moreover, cortical MS remodeling is also associated with the genes enriched in CA1 pyramidal cells and neuron‐specific biological processes. The transcription‐related cortical remodeling in mTBI might reveal the disruption of brain cellular architecture. Therapeutic modalities to intervene in specific cortex and tackle CA1 over‐activation might better encircle the neurobiology of TBI.
Moisture Harvesting by the Structure Regulation of Hygroscopic Hydrogel for Energy and Water Sustainability
Authors: Du Yujie , Zheng Yongliang , Liu Hong , Zhao Shujing , Wang Xiaomian , Yang Lin 
Published: February 2025

AbstractWater and energy are the cornerstones of human development, with more than half of the world's population facing water scarcity issues. Atmospheric moisture is widely distributed around the globe, and the rational utilization of moisture can create tremendous value. Here, the sources of hygroscopic materials, methods of manufacturing hydrogels, properties of these hydrogels, and potential energy applications are concluded. To make the hydrogels with high hydrophilicity, ultrasonic oscillation, freeze drying, and spin coating can be used as the synthesis strategies. The main focus is on the characteristic parameters of hydrogels with water uptake, dehydration temperature, conductivity, mechanical stability, swelling behaviors, and heat transfer coefficient. These unique features will affect the performances of assembles, devices, and instruments. Subsequently, the potential applications of hydrogels are summarized, such as moisture harvesting and splitting with fuel production, dehumidification, thermal management in electronic devices, solar water evaporation, and electricity production. Finally, future directions and issues of interest are proposed to promote the diverse development of hydrogels and relational systems.
High‐Entropy Driven Self‐Assembled Dual‐phase Composite Air Electrodes with Enhanced Performance and Stability for Reversible Protonic Ceramic Cells
Authors: Hu Ao , Yang Chenghao , Li Yitong , Xia Kaisheng , Tian Yunfeng , Pu Jian , Chi Bo 
Published: February 2025

AbstractReversible proton ceramic cells (R‐PCCs) offer a transformative solution for dual functionality in power generation and energy storage. However, their potential is currently obstacles by the lack of high‐performance air electrodes combining high electrocatalytic activity with durability. Here, an innovative air electrode composed of high‐entropy driven self‐assembled xNiO‐Pr0.2La0.2Ba0.2Sr0.2Ca0.2Fe0.8Ni0.2−xO3−δ (N‐XFN) composites is presented, which result from the unique lattice distortion effects inherent in high‐entropy perovskites. The experimental results coupled with density functional theory (DFT) calculations verify that the lattice distortion at the high‐entropy A‐site significantly induces NiO nanoparticles exsolved from the B‐site, promoting the formation of a biphasic composite structure that dramatically increases the electrochemical active sites. Remarkably, R‐PCCs using the N‐XFN composite air electrode achieve an impressive peak power density of 1.30 W cm−2 in fuel cell mode and a current density of ‐2.52 A cm−2 at 1.3 V in electrolysis mode at 650 °C. In addition, the cells show excellent stability with reversibility over 830 h, including 500 h in electrolysis mode and 330 h in reversible operation at 650 °C. This research provides important insights into the design of high‐entropy perovskites, paving the way for advanced R‐PCCs technology.
Mechano‐Electrochemical Healing at the Interphase Between LiNi0.8Co0.1Mn0.1O2 and Li6PS5Cl in All‐Solid‐State Batteries
Authors: Lee Seonghyun , Kim Taehun , Kim Kanghyeon , Song Gawon , Park Junsung , Lee Minseon , Jung Hyeseung , Park Kyobin , Choi Seung Hyun , Song Juyeop , Lee Kyu Tae 
Published: February 2025

AbstractSulfide‐based all‐solid‐state batteries (ASSBs) are emerging as promising alternatives to lithium‐ion batteries due to their high energy density and enhanced safety. However, sulfide solid electrolytes, such as Li6PS5Cl (LPSCl), face significant chemo‐mechanical challenges at the interface with layered oxide cathodes, including Li[Ni0.8Co0.1Mn0.1]O2 (NCM811). During cycling, oxidative decomposition of LPSCl leads to interfacial void formation and mechanical contact loss, which significantly degrade ionic conduction. Strategies such as coating stable passivation layers have been explored to suppress LPSCl decomposition, but these approaches often involve trade‐offs, including increased cost, complex synthesis, and elevated interfacial resistance. Herein, the concept of mechano‐electrochemical healing at the LPSCl–NCM811 interface is introduced to address these issues. During charging, voids form due to LPSCl decomposition; however, this mechanical contact loss can be reversed through a healing mechanism during discharge at ≈2.2 V (vs Li/Li+). This process, driven by the lithiation of elemental sulfur − a decomposition product of LPSCl − restores interfacial contact and enhances ionic conduction. Consequently, mechano‐electrochemical healing achieves stable capacity retention over 300 cycles and superior rate capability even under pressure‐free conditions. These findings underscore the potential of electrochemical formation cycling as a practical strategy for improving the mechano‐electrochemical performance of ASSBs.
Asymmetrically coordinated nickel‐based catalysts for enhanced hydrogen evolution reaction
Authors: Li Shiyi , Wang Keyu , Liang Chen , Lei Linfeng , Wang Yixing , Zhuang Linzhou , Xu Zhi 
Published: February 2025

AbstractDeveloping non‐noble metal hydrogen evolution reaction (HER) catalysts with high efficiency for water dissociation in alkaline environments is crucial for achieving cost‐effective alkaline water electrolyzer. Surface engineering offers immense potential to design promising HER catalysts with enhanced performance, but it faces multiple challenges such as optimizing hydrogen adsorption energy. Herein, Ni‐based hydroxide catalysts doped with heteroatoms are synthesized via electrodeposition, forming a Co‐doped asymmetric S–Ni–F coordination structure, which requires the overpotential of only 20 mV to reach a current density of −10 mA cm−2, and remains stable for over 100 h at −0.5 A cm−2. DFT calculations reveal that sulfur and fluorine doping could effectively mitigate the energy associated with active hydrogen adsorption and facilitate water molecule dissociation. Furthermore, the electron coupling within the d‐orbital of the Ni–O–Co structure further amplifies the catalytic efficacy. This asymmetric structure offering a pathway for designing high‐efficiency and non‐noble metal alkaline HER catalysts.
Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances
Authors: Zhong Hui , Jiang Meiru , Yuan Kun , Sheng Fang , Xu Xiuyun , Cui Yong , Sun Xijia , Tan Wenfei 
Published: February 2025

AbstractBackgroundThe composition of the intestinal flora and the resulting metabolites affect patients' sleep after surgery.MethodsWe intended to elucidate the mechanisms by which disordered intestinal flora modulate the pathophysiology of postoperative sleep disturbances in hosts. In this study, we explored the impacts of anesthesia, surgery, and postoperative sleep duration on the fecal microbiota and metabolites of individuals classified postprocedurally as poor sleepers (PS) and good sleepers (GS), as diagnosed by the bispectral index. We also performed fecal microbiota transplantation in pseudo‐germ‐free (PGF) rats and applied Western blotting, immunohistochemistry, and gut permeability analyses to identify the potential mechanism of its effect.ResultsResearch finding shows the PS group had significantly higher postoperative stool levels of the metabolites tryptophan and kynurenine than the GS group. PGF rats that received gut microbiota from PSs exhibited less rapid eye movement (REM) sleep than those that received GS microbiota (GS‐PGF: 11.4% ± 1.6%, PS‐PGF: 4.8% ± 2.0%, p < 0.001). Measurement of 5‐hydroxytryptophan (5‐HTP) levels in the stool, serum, and prefrontal cortex (PFC) indicated that altered 5‐HTP levels, including reduced levels in the PFC, caused sleep loss in PGF rats transplanted with PS gut flora. Through the brain–gut axis, the inactivity of tryptophan hydroxylase 1 (TPH1) and TPH2 in the colon and PFC, respectively, caused a loss of REM sleep in PGF rats and decreased the 5‐HTP level in the PFC.ConclusionsThese findings indicate that postoperative gut dysbiosis and defective 5‐HTP metabolism may cause postoperative sleep disturbances. Clinicians and sleep researchers may gain new insights from this study.
Enzyme‐Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment‐Responsive Immunomodulation
Authors: Sun Caixia , Liu Songhan , Lau Jun Wei , Yang Hanyu , Chen Yun , Xing Bengang 
Published: February 2025

AbstractPrecise modulation of dynamic and complex tumor microenvironment (TME) to disrupt tumorigenesis and reshape intratumoral immune infiltration has emerged as promising approaches for enhanced cancer therapy. Among recent innovations, proteolysis‐targeting chimeras (PROTACs) represent a burgeoning chemical knockdown technology capable of degrading oncogenic protein homeostasis and inducing dynamic alternations within carcinoma settings, offering potential for antitumor manipulation. However, achieving selectivity in PROTACs that respond to disease environmental stimulation and precisely perturb on‐target proteins remains challenging. The multi‐step synthesis and limited permeability, attributed to high‐molecular‐weight and heterobifunctional structures, further hinder their in vivo efficacy. Herein, we present a unique TME‐responsive enzyme‐activated clickable PROTACs, which features a short peptide‐tagged pomalidomide derivative to undergo tumor‐specific cleavage by cathepsin protease to induce orthogonal crosslinking of the exposed cysteine with 2‐cyanobenzothiazole‐labeled epigenetic protein‐ligand JQ1, facilitating in situ degrader formation within tumor regions only. Systematic protein profiling and proteomic analysis revealed that such TME‐specific clickable‐PROTACs not only selectively eliminate epigenetic proteins without tedious pre‐synthesis to bridge disparate small‐molecule bi‐warhead fragments, but also demonstrated superior tumor penetration compared to conventional high‐molecular‐weight PROTACs. Importantly, these clickable‐PROTACs efficiently downregulated immune checkpoint programmed death‐ligand 1 (PD−L1) both in vitro and in vivo, remodeling TME for enhanced therapeutics, especially in anti‐tumoral immunomodulation.
Quasi‐solid Fiber‐shaped Lithium‐ion Batteries with Fire Resistance
Authors: Cheng Xiangran , Lu Chenhao , Gong Xiaocheng , Li Chuanfa , Wang Jifeng , Qu Jiahe , Zhang Yunting , Song Tianbing , Zhang Yanan , Jiang Haibo , Wang Chuang , Long Yao , Cao Yuanhong , Wang Ying , Li Wei , Peng Huisheng , Wang Bingjie 
Published: February 2025

AbstractFlexible batteries such as scalable fiber‐shaped lithium‐ion batteries (FLIBs) hold great potential for powering wearable electronics due to their excellent electrochemical performance, flexibility, and weavability. However, the use of organic liquid electrolytes raises serious safety concerns, including leakage and combustion hazards. In this study, we develop fire‐resistant lithium cobalt oxide/graphite FLIBs by employing an in situ polymerized gel polymer electrolyte (GPE) incorporating 1,3,3,5,5‐pentafluoro‐1‐ethoxy‐cyclotriphosphazene (PFPN) as a flame retardant and triethylene glycol dimethacrylate (TEGDMA) as a crosslinker. This in situ polymerization of GPE is well‐suited for continuous FLIB production and enhances the electrolyte/electrode interface. The resulting GPE eliminates the inherent flammability of liquid electrolytes with zero self‐extinguishing time, attributed to a dual flame‐retardant mechanism: gas‐phase free radical scavenging and condensed‐phase carbon formation. Notably, the FLIBs using the flame‐retardant GPEs demonstrate no thermal runaway and maintain nonflammability under various abusive conditions, including mechanical abuse (cutting or collision), electrical abuse (overcharging or overdischarging), and thermal abuse (overheating or fire hazards). Additionally, these FLIBs achieve excellent cycling stability over 500 cycles, and retain 99.4 % of capacity after 10,000 bending cycles, highlighting their outstanding durability. This work presents an effective and straightforward approach to greatly enhance the safety and practicality of FLIBs for wearable applications.
Ether‐Embedded Covalent Organic Frameworks Enable Efficient Photocatalytic CO2 Reduction
Authors: Zhou Desen , Chen Qi , Zhang Jun , Wang Tielin , Liu Zhao‐Qing 
Published: February 2025

AbstractThe photocatalytic conversion of carbon dioxide (CO2) into valuable solar fuels is a promising strategy for addressing energy crises and mitigating the greenhouse effect. However, the challenge of efficiently regulating photogenerated electrons to CO2 active sites remains a key hurdle for high‐performance CO2 reduction. Herein, an embedded functional group, ether group is introduced into porphyrin‐triazine COFs to regulate the transfer behavior of photogenerated electrons. The ether‐embedded COFs (TOT‐TAPP, BOD‐TAPP and QOB‐TAPP) demonstrate significantly faster charge transport and higher photoactivity compared with the corresponding non‐ether‐embedded counterpart COFs. The theoretical calculations and in situ characterizations reveal that the ether group could not only accelerate the separation of photogenerated charge carriers, but also lead to a more substantial accumulation of electrons at the CO2 adsorption region (C=N imine bond), thus greatly promoting the efficiency of CO2 photoreduction.
Chiral Communication between Enantiomeric Sergeants and Achiral Soldiers in Racemic Triblock Copolymers with Heterochiral Cores for Triggering Multiple Helicity Inversions
Authors: He Zixiang , Ma Haotian , Tang Zeyu , Cheng Xiaoxiao , Zhang Wei 
Published: February 2025

AbstractAmplification of asymmetry in complex supramolecular/polymer system results from the delicate interplay of chiral and achiral structures. Here, a novel approach to the racemic sergeants and soldiers (S&S) effect, using enantiomeric sergeants (Sgt.) and achiral soldiers (Sold.), achieves unique precise control over both intensity and sign of global chirality. Chiroptical assemblies of different dimensions in racemic S&S copolymers can be constructed in situ via polymerization‐induced chiral self‐assembly (PICSA). We systemically investigated chiral communication pathways between chiral‐chiral, chiral‐achiral, and two oppositely configured azobenzene (Azo) segments, which robustly affect the global chiroptical activity of the racemic S&S assemblies. Chain length‐, Sgt./Sold. ratios‐, and temperature‐dependent CD/UV/Vis, small‐angle X‐ray scattering (SAXS), wide‐angle X‐ray diffraction (WAXD), differential scanning calorimetry (DSC) and polarized optical microscopy (POM) results provided insights into the kinetics for chiroptical inversions. LC phase transitions, the helical preferences of the Sgt. and Sold. units, and the stability of the “chiral core” allow racemic S&S copolymer assemblies to exhibit chiral conflict between heterochiral blocks in an enantioselective fashion.
Elucidating the Biosynthesis and Function of an Autoinducing Peptide in Clostridium acetobutylicum
Authors: Zhu Chao , Wang Zixuan , Zhou Xiaoyu , Wu Youduo , Kang Wei , Wu Ren'an , Xue Chuang 
Published: February 2025

AbstractClostridia produce autoinducing peptides (AIPs) regulated by the accessory gene regulator (Agr) quorum sensing system, playing a critical role in intercellular communication. However, the biosynthetic pathway and regulatory functions of clostridial AIPs remain inadequately characterized. In this study, we employed chemical quantification, genetic investigations, and in vitro reconstitution experiments to elucidate the native Ca‐AIP in Clostridium acetobutylicum, a prominent industrial producer of acetone, butanol, and ethanol. Our findings identified a signal peptidase (Cac1760) and two CAAX metalloproteases (Cac0077 and Cac2478) as key players in N‐terminal cleavage, while AgrB was found to be essential for C‐terminal processing during Ca‐AIP biosynthesis. Notably, overexpression of agrBD led to a 4.4‐fold enhancement in Ca‐AIP formation, which corresponded with an increase in butanol production from 12.5 to 14.9 g/L, while preserving vegetative cell morphology. The direct involvement of Ca‐AIP in both butanol production and maintenance of cell morphology was further validated through exogenous supplementation. Collectively, these results provide novel insights into the biosynthesis of AIPs and propose a promising strategy for optimizing microbial processes in industrial applications.