bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulp washing: Influence of temperature on lignin leaching from kraft pulps
Authors: Eriksson Gunnar , Grén Urban 
Published: May 2007

Abstract
The leaching of lignin from the fibre wall was studied in order to investigate the effects in the clean end of the fibre line. The focus was set on the short time intervals representative for the washing operation in industrial applications. The influence of temperature, pulp type and kappa number was investigated. It could be seen that there are different diffusivities for the soluble lignin in the wall at short and long time of leaching, probably due to the existence of a more open structure in an outer layer of the fibre wall, in which the lignin diffuses more easily and which is also emptied relatively fast, while diffusion of the lignin from the inner layers is significantly slower. There is also a relation between the leaching of sodium ions out of the wall and the short diffusion time of lignin, indicating a possible ion-ion interaction with the lignin in the outer layer of the fibre wall. The diffusivity of lignin increases more rapidly at temperatures above 80-90 "C. This temperature effect was confirmed in the results of wash test equipment experiments, giving noticeable differences above 100 "C. It was found that the experimentally determined lignin diffusivity differs for different kappa number and for type of pulp. The general behaviour of the phenomena, however, is the same.
Calendering of coated paper and board in an extended soft nip
Authors: Wikström M. , Nylund T. , Rigdahl M. 
Published: May 2007

Abstract
Several coated paper products were calendered at different line loads with an extended soft nip, a conventional soft (polymer/steel) nip and a hard (steel/steel) nip. The central roll of the calender was heated to different temperatures; 140, 180 and 210 oC with the extended soft nip, 140 oC with the conventional soft nip and 140 and 180 "C with the hard nip. Calendering with the extended soft nip resulted in general in a paper product with a more uniform structure than that obtained when the other two types of nips were used. This was reflected in lower gloss variations of the coated surface and in a lower variance in the reflectance of paper samples subjected to a bum-out treatment. The latter may be interpreted in terms of a more uniform pore structure in the coating layer. Offset prints on a coated woodfree paper chiendered with the extended soft nip were less mottled than prints on the same paper calendered with the conventional soft nip. There was apparently a correlation between the variance in the bum-out reflectance of the paper samples and the mottle in the offset print. The effect of the extended soft nip on gloss, print gloss, surface roughness and bending stiffness is also reported.
Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes
Authors: Almuwaqqat Zakaria , Hui Qin , Liu Chang , Zhou Jin J. , Voight Benjamin F. , Ho Yuk-Lam , Posner Daniel C. , Vassy Jason L. , Gaziano J. Michael , Cho Kelly , Wilson Peter W. F. , Sun Yan V. 
Published: March 2024

ImportanceBody mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is a commonly used estimate of obesity, which is a complex trait affected by genetic and lifestyle factors. Marked weight gain and loss could be associated with adverse biological processes.ObjectiveTo evaluate the association between BMI variability and incident cardiovascular disease (CVD) events in 2 distinct cohorts.Design, Setting, and ParticipantsThis cohort study used data from the Million Veteran Program (MVP) between 2011 and 2018 and participants in the UK Biobank (UKB) enrolled between 2006 and 2010. Participants were followed up for a median of 3.8 (5th-95th percentile, 3.5) years. Participants with baseline CVD or cancer were excluded. Data were analyzed from September 2022 and September 2023.ExposureBMI variability was calculated by the retrospective SD and coefficient of variation (CV) using multiple clinical BMI measurements up to the baseline.Main Outcomes and MeasuresThe main outcome was incident composite CVD events (incident nonfatal myocardial infarction, acute ischemic stroke, and cardiovascular death), assessed using Cox proportional hazards modeling after adjustment for CVD risk factors, including age, sex, mean BMI, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, smoking status, diabetes status, and statin use. Secondary analysis assessed whether associations were dependent on the polygenic score of BMI.ResultsAmong 92 363 US veterans in the MVP cohort (81 675 [88%] male; mean [SD] age, 56.7 [14.1] years), there were 9695 Hispanic participants, 22 488 non-Hispanic Black participants, and 60 180 non-Hispanic White participants. A total of 4811 composite CVD events were observed from 2011 to 2018. The CV of BMI was associated with 16% higher risk for composite CVD across all groups (hazard ratio [HR], 1.16; 95% CI, 1.13-1.19). These associations were unchanged among subgroups and after adjustment for the polygenic score of BMI. The UKB cohort included 65 047 individuals (mean [SD] age, 57.30 (7.77) years; 38 065 [59%] female) and had 6934 composite CVD events. Each 1-SD increase in BMI variability in the UKB cohort was associated with 8% increased risk of cardiovascular death (HR, 1.08; 95% CI, 1.04-1.11).Conclusions and RelevanceThis cohort study found that among US veterans, higher BMI variability was a significant risk marker associated with adverse cardiovascular events independent of mean BMI across major racial and ethnic groups. Results were consistent in the UKB for the cardiovascular death end point. Further studies should investigate the phenotype of high BMI variability.
PARP Inhibitors for Breast Cancer Treatment
Authors: Morganti Stefania , Marra Antonio , De Angelis Carmine , Toss Angela , Licata Luca , Giugliano, Federica , Taurelli Salimbeni Beatrice , Berton Giachetti Pier Paolo Maria , Esposito Angela , Giordano Antonio , Bianchini Giampaolo , Garber Judy E. , Curigliano Giuseppe , Lynce Filipa , Criscitiello Carmen 
Published: March 2024

ImportancePoly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors have revolutionized the treatment of patients with germline BRCA1/2-associated breast cancer, representing the first targeted therapy capable of improving outcomes in patients with hereditary tumors. However, resistance to PARP inhibitors occurs in almost all patients.ObservationsThis narrative review summarizes the biological rationale behind the use of PARP inhibitors in breast cancer, as well as the available evidence, recent progress, and potential future applications of these agents. Recent studies have shown that the benefit of PARP inhibitors extends beyond patients with germline BRCA1/2-associated metastatic breast cancer to patients with somatic BRCA1/2 variants and to those with germline PALB2 alterations. Moreover, these agents proved to be effective both in the metastatic and adjuvant settings. However, patients with metastatic breast cancer usually do not achieve the long-term benefit from PARP inhibitors observed in other tumor types. Mechanisms of resistance have been identified, but how to effectively target them is largely unknown. Ongoing research is investigating both novel therapeutics and new combination strategies to overcome resistance. PARP1-selective inhibitors, by sparing the hematological toxic effects induced by the PARP2 blockade, are promising agents to be combined with chemotherapy, antibody-drug conjugates, and other targeted therapies.Conclusions and RelevanceAlthough the efficacy of PARP inhibitors is well established, many questions persist. Future research should focus on identifying predictive biomarkers and therapeutic strategies to overcome resistance. Integrating well-designed translational efforts into all clinical studies is thereby crucial to laying the groundwork for future insights from ongoing research.
The Influence of Mo Content and Annealing on the Oxidation Behavior of Arc‐Melted Cr–xMo–8Si Alloys
Authors: Koliotassis Lisa , White Emma M. H. , Galetz Mathias C. 
Published: March 2024

The influence of Mo (10–40 at%) additions to Cr–8 at%Si is systematically studied by analyzing arc‐melted alloys in the as‐cast and annealed state. The oxidation resistance is tested by thermogravimetric analysis (TGA) at 1200 °C in air for up to 100 h. Samples are characterized by X‐ray diffraction, scanning electron microscopy, and wavelength‐dispersive X‐ray spectroscopy. The studied Cr–xMo–8Si alloy series shows a beneficial effect of Mo on the corrosion behavior. For all of the investigated Mo contents, no nitridation is observed and the oxide scale adhesion is improved. An increased amount of intermetallic A15 phase leads to the formation of a SiO2 scale beneath the Cr2O3 layer during high‐temperature exposure. The internal SiO2 layer inhibits further internal oxidation of the A15 phase. Uniform size and distribution of A15, benefits the formation of a duplex oxide scale. Cr–25Mo–8 at%Si, shows the most promising oxidation behavior. The TGA data follows the paralinear law, with both the growth rate, kp, and volatilization rate, kv, of Cr2O3 being reduced by adding 10–25 at% Mo. A binary Cr/Mo–Si phase diagram is generated in order to determine accurate annealing conditions and estimate the stability range of the metastable σ phase.
Polarization‐Sensitive Photodetector Based on Quasi‐1D (TaSe4)2I Nanowire Response to 10.6 µm
Authors: Wei Binbin , Zou Bingqian , Liu Jinxin , Wang Wenhui , Wang Wanqian , Cao Zhangyu , Han Tao , Li Feng , Luo Wei , Shan Lei , Long Mingsheng 
Published: March 2024

AbstractPolarization‐sensitive infrared (IR) photodetection plays an important role in fiber optic communication, environmental monitoring, and remote sensing imaging. Semiconductors with quasi‐1D crystal structures exhibit unique optical and electrical properties due to their 1D carrier transport channels and large surface area‐to‐volume ratio, offering the possibility of high‐performance photodetectors with high photogain (G), polarization sensitivity photodetection. Herein, an ultra‐broadband photodetection (405 nm–10.6 µm) based on a quasi‐1D (TaSe4)2I single‐crystal nanowire is reported. The (TaSe4)2I photodetector exhibits excellent polarization‐sensitive photodetection, with a high dichroic ratio of Imax/Imin = 2.32 under 637 nm illumination. Notably, the (TaSe4)2I nanowire photodetector exhibits a competitive performance in uncooled mid‐wave infrared (MWIR) detection with a high photoresponsivity (R) of 110.5 AW−1 and specific detectivity (D*) of 4.8 × 1010 cmHz1/2W−1. Moreover, in the long‐wave infrared (LWIR) spectral range, an R of 67.6 mAW−1 is demonstrated at room temperature (RT). The (TaSe4)2I nanowire photodetector enables significant advancements for polarization‐sensitive and uncooled MWIR and LWIR photodetection.
Unleashing a Dual‐Warhead Nanomedicine to Precisely Sensitize Immunotherapy for Pancreatic Ductal Adenocarcinoma
Authors: Zhang Di , Song Qingxu , Wang Wenjuan , Li Qian , Zhao Zhipeng , Jiang Yue , Luan Yuxia 
Published: March 2024

AbstractDespite remarkable achievements in cancer immunotherapy, significant challenges persist in pancreatic ductal adenocarcinoma (PDAC) treatment. Particularly, there is a critical issue of inadequate intratumoral infiltration of effector T cells, primarily attributed to the physical “hard” barrier caused by extracellular matrix (ECM) and the “soft” barrier imposed by immune suppression. Here, a dual‐warhead nanomedicine is reported that effectively targets and attacks the barriers to precisely sensitize PDAC immunotherapy. The nanomedicine is achieved by designing tumor cell membrane vesicle (TMV)‐coated polyamidoamine dendrimer‐condensed siRNA complexes, with hedgehog inhibitor encapsulated in TMV bilayers. With the precision‐guided stealth feature of TMV coating, the nanomedicine achieved powerful tumor‐targeting co‐delivery of hedgehog inhibitor and siRNA, resulting in a significant decrease in collagen I secretion and efficient silencing of the target gene to disrupt the ECM and immune suppression barriers. This nanomedicine enables robust immunity against PDAC progression and metastasis, offering a potent approach to PDAC therapy.
Evolution of Self‐Assembled Lignin Nanostructure into Dendritic Fiber in Aqueous Biphasic Photocurable Resin for DLP‐Printing
Authors: Wang Luyao , Wu Ruijie , Wang Qingbo , Backman Oskar , Eklund Patrik , Wang Xiaoju , Xu Chunlin 
Published: March 2024

AbstractThe design of lignin nanostructures where interfacial interactions enable enhanced entanglement of colloidal networks can broaden their applications in hydrogel‐based materials and light‐based 3D printing. Herein, an approach for fabricating surface‐active dendritic colloidal microparticles (DCMs) characterized by fibrous structures using nanostructured allylated lignin is proposed for the development of lignin‐based photocurable resins. With allyl‐terminated surface functionality of 0.61 mmol g−1, the entanglement between lignin‐DCM fibrils with a size of 1.4 µm successfully produces only lignin‐based hydrogels with structural integrity through photo‐crosslinking. The colloidal network of lignin dendricolloids reinforces the poly(ethylene glycol) (PEG) hydrogels during a digital light processing (DLP) 3D printing process by generating bicontinuous morphologies, resulting in six‐fold increases in toughness values with respect to the neat PEG hydrogel. The dual effectiveness of photoabsorption and free‐radical reactivity of lignin‐DCMs allow the light‐patterning of rather dilute PEG hydrogels (5–10%) with high geometric fidelity and structural complexity via DLP 3D printing. This study demonstrates a green and effective strategy for the design of 1D lignin‐DCMs that increases the versatility of the nanostructured biopolymer, opening up numerous opportunities for formulating functional hydrogels with robust structure‐property correlations.
Tough Adhesive Puncture Sealing Sutures with Swelling Triggered Bioadhesion for Enhanced Wound Closure
Authors: Ma Zhenwei , Nguyen Alex , Chung‐Tze‐Cheong Christopher , Mazy David , Ghezelbash Farshid , Yang Zhen , Liu Yin , Liu Shiyu , Lamer Stéphanie , Gao Zu‐hua , Obuseh Favour , Freedman Benjamin R. , Nault Marie‐Lyne , Li Jianyu 
Published: March 2024

AbstractSurgical sutures are gold‐standard wound closure devices. However, they are unable to form a tight seal with surrounding tissues, raising the risks of body fluid leakage and surgical site infection. Additionally, the use of sutures can result in cracking at suture roots, damage and micro‐trauma to soft tissues due to the slicing and compression of suture fibers after their placement. Bioadhesives capable of mimicking natural biological interfaces are appealing alternatives, but they cannot achieve the same level of strength as conventional surgical sutures. Here, a tough adhesive puncture sealing (TAPS) suture, featuring swelling‐triggered bioadhesion to mend the gap between the suture and the surrounding tissues with a soft yet tough adhesive interface is reported. This unique design principle of TAPS sutures is applicable to diverse soft tissues of various defect sizes and can be controlled by modulating the hydrogel swelling kinetics. The advantages of the TAPS sutures for meniscal tear repair and intestine tissue sealing ex vivo, corroborates their favorable applications in managing mechanically active musculoskeletal and gastrointestinal tissues are demonstrated. The design and performance of the TAPS sutures offer extensive possibilities for redesigning surgical tools and developing next‐generation medical devices for wound management and tissue repair.
Enhanced Performance in Cesium Tellurium Chlorine by Hafnium Alloying for X‐Ray Computed Tomography Imaging
Authors: Lai Jun'an , Wang Pengjiu , Zheng Baofeng , Xuan Tongtong , Wu Daofu , Wang Zixian , Wang Yijia , Zhang Wenxia , Du Juan , He Peng , An Kang , Tang Xiaosheng 
Published: March 2024

AbstractThe term “light yield” (LY) refers to the ability of scintillator materials to convert high‐energy radiation into visible light. A higher LY corresponds to improved energy and spatial resolution in detectors. The enhancement of scintillator material performance is a crucial aspect of their development. In this study, the Cs2TeCl6 (CTC) double perovskite microcrystals is synthesized, and the broadband yellow emission shows a high degree of matching with the Charge‐coupled Device (CCD). However, the LY of CTC is poor for practical applications in X‐ray imaging. The scintillation performance is significantly enhanced through hafnium alloying. The LY increased from ≈4167 to 38 523 photons/MeV, and the detection limit decreased from 948 to 258 nGy s−1. The underlying mechanism of Te4+ ions emission is systematically explored through density function theory (DFT) analysis, along with investigations into pressure‐dependent photoluminescence, temperature‐dependent photoluminescence, and low‐temperature thermoluminescence. Furthermore, a flexible X‐ray scintillator screen with an outstanding high spatial resolution of 15.9 lp mm−1 is successfully fabricated. This work not only represents a substantial advancement in the scintillation performance of Te4+ ions emission double perovskite microcrystals but also provides an effective strategy for the development of the next generation of halide scintillators.
Targeted Repair of Spinal Cord Injury Based on miRNA‐124‐3p–Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein
Authors: Fan Xiangchuang , Shi Lusen , Yang Zimeng , Li Yiwei , Zhang Chi , Bai Baoshuai , Chen Lu , Yilihamu Elzat Elham‐Yilizati , Qi Zhangyang , Li Wenxiang , Xiao Peng , Liu Mingshan , Qiu Jichuan , Yang Fan , Ran Ning , Shang Yifan , Liu Jiaxing , Zhang Tehan , Kong Xiaohong , Liu Hong , Zhou Hengxing , Feng Shiqing 
Published: March 2024

AbstractSpinal cord injury (SCI) has no effective treatment modalities. It faces a significant global therapeutical challenge, given its features of poor axon regeneration, progressive local inflammation, and inefficient systemic drug delivery due to the blood–spinal cord barrier (BSCB). To address these challenges, a new nano complex that achieves targeted drug delivery to the damaged spinal cord is proposed, which contains a mesoporous silica nanoparticle core loaded with microRNA and a cloaking layer of human umbilical cord mesenchymal stem cell membrane modified with rabies virus glycoprotein (RVG). The nano complex more readily crosses the damaged BSCB with its exosome‐resembling properties, including appropriate size and a low‐immunogenic cell membrane disguise and accumulates in the injury center because of RVG, where it releases abundant microRNAs to elicit axon sprouting and rehabilitate the inflammatory microenvironment. Culturing with nano complexes promotes axonal growth in neurons and M2 polarization in microglia. Furthermore, it showed that SCI mice treated with this nano complex by tail vein injection display significant improvement in axon regrowth, microenvironment regulation, and functional restoration. The efficacy and biocompatibility of the targeted delivery of microRNA by nano complexes demonstrate their immense potential as a noninvasive treatment for SCI.
Harnessing Atomically Dispersed Cobalt for the Reductive Catalytic Fractionation of Lignocellulose
Authors: Li Xiancheng , Ma Rumin , Gao Xueying , Li Helong , Wang Shuizhong , Song Guoyong 
Published: March 2024

AbstractThe reductive catalytic fractionation (RCF) of lignocellulose, considering lignin valorization at design time, has demonstrated the entire utilization of all lignocellulose components; however, such processes always require catalysts based on precious metals or high‐loaded nonprecious metals. Herein, the study develops an ultra‐low loaded, atomically dispersed cobalt catalyst, which displays an exceptional performance in the RCF of lignocellulose. An approximately theoretical maximum yield of phenolic monomers (48.3 wt.%) from lignin is realized, rivaling precious metal catalysts. High selectivity toward 4‐propyl‐substituted guaiacol/syringol facilitates their purification and follows syntheses of highly adhesive polyesters. Lignin nanoparticles (LNPs) are generated by simple treatment of the obtained phenolic dimers and oligomers. RCF‐resulted carbohydrate pulp are more obedient to enzymatic hydrolysis. Experimental studies on lignin model compounds reveal the concerted cleavage of Cα–O and Cβ–O pathway for the rupture of β‐O‐4 structure. Overall, the approach involves valorizing products derived from lignin biopolymer, providing the opportunity for the comprehensive utilization of all components within lignocellulose.
Robust Anode‐Free Sodium Batteries with Durably Sodophilic Interfaces by Suppressing Sodium‐Alloy Transformation
Authors: Xie Chunlin , Wu Hao , Dai Jiawen , Fu Zhouhao , Zhang Rui , Ji Huimin , Zhang Qi , Tang Yougen , Qiu Tian , Wang Haiyan 
Published: March 2024

AbstractAnode‐free sodium batteries (AFSBs) are a desirable choice for high‐energy‐density and low‐cost battery systems. However, the rapid capacity decline resulting from irreversible sodium plating and stripping remains a big challenge for AFSBs. Herein, a copper‐dominated Cu2Sb composite coating employing a co‐sputtering strategy is designed to improve the sodophilicity of copper foils. The Cu2Sb coating can construct a durably sodophilic and stable interface by suppressing the alloying transition of the sodophilic phase and alleviating the volumetric deformation of the coating. This stable alloy interface can greatly enhance sodium nucleation and improve ion transport at the interface by forming homogeneous NaF‐rich solid electrolyte interphase (SEI) film. Ultimately, the AFSB assembled using this unique substrate with a highly loaded Na3V2(PO4)3 (NVP) cathode (≈10 mg cm−2) can cycle 600 cycles deliver a discharge capacity of 75.4 mAh g−1 with a capacity retention of 74.2%, which is much higher than those of the untreated one or antimony coating one (<30% after 200 cycles). This co‐sputtering strategy provides new insights into the design of sodophilic coatings with sodium‐alloying ability and can be extended to the optimization of zinc‐metal batteries.