bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia
Authors: Yang Jun , Epling-Burnette P. K. , Painter Jeffrey S. , Zou JianXiang , Bai Fanqi , Wei Sheng , Loughran Thomas P. 
Published: November 2007

Abstract
Clonal T-cell expansion in patients with T-large-granular lymphocyte (LGL) leukemia occurs by an undefined mechanism that may be related to Fas apoptosis resistance. Here, we demonstrate polarized expansion of CD8+ terminal-memory differentiation in such patients, as demonstrated by CD45RA expression and absence of CD62L expression, suggesting repeated stimulation by antigen in vivo. Elimination of antigen-stimulated T cells normally occurs through Fas-mediated apoptosis. We show that cells from LGL leukemia patients express increased levels of c-FLIP and display resistance to Fas-mediated apoptosis and abridged recruitment of proteins that comprise the death-inducing signaling complex (DISC), including the Fas-associated protein with death-domain (FADD) and caspase-8. Exposure to interleukin-2 (IL-2) for only 24 hours sensitized leukemic LGL to Fas-mediated apoptosis with enhanced formation of the DISC, and increased caspase-8 and caspase-3 activities. We observed dysregulation of c-FLIP by IL-2 in leukemic LGL, suggesting a role in Fas resistance. Our results demonstrate that expanded T cells in patients with LGL leukemia display both functional and phenotypic characteristics of prior antigen activation in vivo and display reduced capacity for Fas-mediated DISC formation.
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels
Authors: Au Patrick , Daheron Laurence M. , Duda Dan G. , Cohen Kenneth S. , Tyrrell James A. , Lanning Ryan M. , Fukumura Dai , Scadden David T. , Jain Rakesh K. 
Published: November 2007

Abstract
Tissue engineering requires formation of a de novo stable vascular network. Because of their ability to proliferate, differentiate into endothelial cells, and form new vessels, blood-derived endothelial progenitor cells (EPCs) are attractive source of cells for use in engineering blood vessels. However, the durability and function of EPC-derived vessels implanted in vivo are unclear. To this end, we directly compared formation and functions of tissue-engineered blood vessels generated by peripheral blood– and umbilical cord blood–derived EPCs in a model of in vivo vasculogenesis. We found that adult peripheral blood EPCs form blood vessels that are unstable and regress within 3 weeks. In contrast, umbilical cord blood EPCs form normal-functioning blood vessels that last for more than 4 months. These vessels exhibit normal blood flow, perm-selectivity to macromolecules, and induction of leukocyte-endothelial interactions in response to cytokine activation similar to normal vessels. Thus, umbilical cord blood EPCs hold great therapeutic potential, and their use should be pursued for vascular engineering.
Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythrocyte production by a different mechanism than erythropoietin
Authors: Rhodes Melissa M. , Kopsombut Prapaporn , Bondurant Maurice C. , Price James O. , Koury Mark J. 
Published: November 2007

AbstractErythroblasts adhere to central macrophages forming erythroblastic islands in hematopoietic tissues, but the function of these islands is not understood. Murine erythroblastic islands were reconstituted in vitro with macrophages and developmentally synchronous proerythroblasts. Erythroblasts cocultured with macrophages proliferated 3-fold greater than erythroblasts cultured alone. Direct contact with the macrophages was necessary for this enhanced erythroblast proliferation, which resulted from decreased transit time in the G0/G1 phase of cell cycle. Increased erythroblast proliferation in erythroblastic islands occurred over a wide range of erythropoietin concentrations and was the result of a mechanism different from the antiapoptotic effect of erythropoietin. Erythroblasts adherent to macrophages had slightly delayed enucleation, but otherwise differentiation was similar to erythroblasts cultured alone or those that became nonadherent in cocultures. These results suggest a mechanism for the development of anemias associated with abnormal macrophage function and for reduced responsiveness of those anemias to erythropoietin therapy.
NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities
Authors: Diermayr Stefan , Himmelreich Heike , Durovic Bojana , Mathys-Schneeberger Arina , Siegler Uwe , Langenkamp Ulrich , Hofsteenge Jan , Gratwohl Alois , Tichelli André , Paluszewska Monika , Wiktor-Jedrzejczak Wieslaw , Kalberer Christian P. , Wodnar-Filipowicz Aleksandra 
Published: November 2007

Abstract
This study exploited alloreactivity of natural killer (NK) cells for augmenting the recognition of human acute myeloid leukemia (AML). To circumvent the inhibitory effect of killer immunoglobulin receptor (KIR) signaling, we generated NK-cell lines with single KIR specificities for major human leukocyte antigen (HLA) class I allotypes. We demonstrated efficient cytolysis of KIR-HLA class I–mismatched primary AML blasts even at low effector-to-target ratios. To define the impact of tumor-associated activating NKG2D-ligands (NKG2D-L), 66 AML patients at diagnosis were analyzed. NKG2D-L were selectively expressed on monoblastic cells in AML M4 and M5 yet absent or weakly expressed on myeloblastic cells in all AML subtypes. Paucity of cell-surface NKG2D-L was not the result of shedding because levels of soluble ULBP1 ligand measured in AML plasma were in the normal range. Notably, purified NKG2D-L+ monoblastic cells were more susceptible to NK-mediated killing than NKG2D-L− myeloblastic cells. Accordingly, induction of cell-surface NKG2D-L by treatment with the histone deacetylase inhibitor, valproic acid, rendered cells more sensitive to NK cytolysis. These data suggest that adoptive transfer of selected populations of alloreactive HLA class I–mismatched NK cells in combination with pharmacologic induction of NKG2D-L merits clinical evaluation as novel approaches to immunotherapy of human AML.
A manually curated database of tetrapod mitochondrially encoded tRNA sequences and secondary structures
Authors: Popadin Konstantin Yu , Mamirova Leila A , Kondrashov Fyodor A 
Published: November 2007

Abstract

Background
Mitochondrial tRNAs have been the subject of study for structural biologists interested in their secondary structure characteristics, evolutionary biologists have researched patterns of compensatory and structural evolution and medical studies have been directed towards understanding the basis of human disease. However, an up to date, manually curated database of mitochondrially encoded tRNAs from higher animals is currently not available.

Description
We obtained the complete mitochondrial sequence for 277 tetrapod species from GenBank and re-annotated all of the tRNAs based on a multiple alignment of each tRNA gene and secondary structure prediction made independently for each tRNA. The mitochondrial (mt) tRNA sequences and the secondary structure based multiple alignments are freely available as Supplemental Information online.

Conclusion
We compiled a manually curated database of mitochondrially encoded tRNAs from tetrapods with completely sequenced genomes. In the course of our work, we reannotated more than 10% of all tetrapod mt-tRNAs and subsequently predicted the secondary structures of 6060 mitochondrial tRNAs. This carefully constructed database can be utilized to enhance our knowledge in several different fields including the evolution of mt-tRNA secondary structure and prediction of pathogenic mt-tRNA mutations. In addition, researchers reporting novel mitochondrial genome sequences should check their tRNA gene annotations against our database to ensure a higher level of fidelity of their annotation.
Carlos Poveda's Menu
Authors: ross marjorie 
Published: November 2007

Carlos Poveda's Domestic Landscapes are linked to a history of food and art that reaches back to Greco-Roman antiquity and becomes empowered with contemporary artists who sculpt or paint their works in edible materials to be devoured by spectators. Poveda's Landscapes, however, offer food that is symbolic——inedible.
He reinvents the organic by using industrial refuse that he converts, colors, and models in a cauldron in a process as akin to alchemy as to cooking. His is not a faithful transcription of meals in the style of classical still lifes, but rather an artistic overlapping of emotions, that surround the idea of the edible. Looking at his sculptures we may feel revulsion, but what sickens us is not so much his creation as the awareness it brings of our intrinsically predatory nature. He gives us an art form that not only fails to provoke appetite but also touches our deepest culinary memories and leads us back to a primal past by asserting the significance of food in our collective memory.
Ultimately, our strongest reaction to his work may be the fear that we won't be able to digest the absurdity of our daily life.
Probing Logics of Membership: Contributions on Statism and Nationalism in Germany and Beyond
Authors: Freyberg-Inan Annette 
Published: November 2007

Gregg O. Kvistad, The Rise and Demise of German Statism: Loyalty and Political Membership (Providence and Oxford: Berghahn Books, 1999)Hartmut Lehmann and Hermann Wellenreuther (eds.), German and American Nationalism: A Comparative Perspective (Oxford and New York: Berg, 1999)
Finding Oneself in History and Vice Versa: Remarks on &quot;George's Voice&quot;
Authors: Breines Paul 
Published: November 2007

This article is dedicated to John Tortorice, associate director of developmentin the library at the University of Wisconsin-Madison andGeorge Mosse’s life-partner. As muse and critic, John worked closelywith George on the latter’s memoir. After George’s death, John sawthe work into print, under the title, Confronting History (University ofWisconsin Press, 2000). The press did not accept the original titleJohn had generated, “Finding Myself in History.” This is unfortunatebecause it is a fine double entendre that fits the memoir perfectly. Toacknowledge that title and to honor John and the joy and new possibilitieshe brought into George’s life, I have borrowed from him in thetitle of these remarks.
Adorno's Scars, Bloch's Anacoluthon
Authors: Richter Gerhard 
Published: November 2007

Theodor W. Adorno, Aesthetic Theory, newly translated, edited, and with a translator’s introduction by Robert Hullot-Kentor (Minneapolis: University of Minnesota Press, 1997)Ernst Bloch, Literary Essays, trans. Andrew Joron, et. al. (Stanford: Stanford University Press, 1998)
New Patterns in the East? Differences in Voting Behavior and Consequences for Party Politics in Germany
Authors: Eith Ulrich 
Published: November 2007

On 9 November 1989, the government of the German DemocraticRepublic decided to open the Berlin Wall, effectively signaling thecollapse of the socialist system in East Germany. The subsequenttransformation of the country’s political structures, and in particularthat of its political parties, took place in two phases. In the firstphase, directly after the fall of the wall, the GDR’s political systemunderwent a radical democratic and pluralistic overhaul withoutWest German involvement—although the existence of a second Germanstate, the Federal Republic of Germany, naturally influencedthe goals, strategies, and scope of action of the actors concerned.
Book Reviews
Authors: McFalls Laurence , Anderson Jeffrey J. , Beck Vanessa 
Published: November 2007

Jennifer A. Yoder, From East Germans to Germans? The New Postcommunist Elitesn(Durham: Duke University Press, 1999)Review by Laurence McFallsHölscher, Jens and Anja Hochberg, eds., East Germany’s Economic Development Since Unification: Domestic and Global Aspects (New York: St. Martin’s Press, 1998)Review by Jeffrey J. AndersonBrigitte Young, Triumph of the Fatherland. German Unification and the Marginalization of Women (Ann Arbor: University of Michigan Press, 1999) Review by Vanessa Beck
Identical with What? Chartering the Unknown Waters of the Concept of Identity
Authors: Hess Andreas 
Published: November 2007

Andreas Glaeser Divided in Unity—Identity, Germany, and the Berlin Police (Chicago: University Of Chicago Press, 2000)Lutz Niethammer Kollektive Identität—Heimliche Quellen Einer Unheimlichen Kultur (Hamburg: Rowohlts Enzyklopädie, 2000)
Russians, Americans, and Their Germanies
Authors: Livingston Robert Gerald 
Published: November 2007

Hannes Adomeit, Imperial Overstretch: Germany in Soviet Policy from Stalin to Gorbachev (Baden-Baden: Nomos Verlagsgesellschaft, 1998 )W.R. Smyser, From Yalta to Berlin: The Cold War Struggle over Germany (New York: St. Martin’s Press, 1999)Angela E. Stent, Russia and Germany Reborn: Unification, The Soviet Collapse, and the New Europe (Princeton, New Jersey: Princeton Uni- versity Press, 1999)
Making Money: The Bundesbank and the German Political Economy
Authors: Zatlin Jonathan R. 
Published: November 2007

Stephen F. Frowen and Robert Pringle, eds., Inside the Bundesbank (St. Martins Press: New York, 1998)Peter A. Johnson, The Government of Money: Monetarism in Germany and the United States (Cornell University Press: Ithaca and London, 1998)Karl Kaltenthaler, Germany and the Politics of Europe’s Money (Duke University Press: Durham and London 1998)
A Nation in White: Germany’s Hygienic Consensus and the Ambiguities of Modernist Architecture
Authors: Rollins Williams 
Published: November 2007

“White, everything white.” White was the color of the WeimarRepublic, or at least so it seemed to cultural critic J. E. Hammannwriting in the journal Die Form in 1930. In his article Hammann didnot just note the trend toward white in interior design, but rather hewas determined to understand the greater significance in his fellowGermans’ overwhelming color preference. White, Hammann surmised,was a “characteristic mark of the way in which we grasp ourage,” a “chief indicator of the times,” and a powerful evocation ofthe “new spirit” behind Weimar’s “modern weltanschauung” (121f.).
Environmentalists, Nuclear Waste, and the Politics of Passive Exclusion in Germany
Authors: Hunold Christian 
Published: November 2007

In this essay I examine the dispute between the German GreenParty and some of the country’s environmental nongovernmentalorganizations (NGOs) over the March 2001 renewal of rail shipmentsof highly radioactive wastes to Gorleben. My purpose indoing so is to test John Dryzek’s 1996 claim that environmentalistsought to beware of what they wish for concerning inclusion in theliberal democratic state. Inclusion on the wrong terms, arguesDryzek, may prove detrimental to the goals of greening and democratizingpublic policy because such inclusion may compromise thesurvival of a green public sphere that is vital to both. Prospects forecological democracy, understood in terms of strong ecologicalmodernization here, depend on historically conditioned relationshipsbetween the state and the environmental movement that fosterthe emergence and persistence over time of such a public sphere.
Democracy, Federalism, and the European Union: The Pitfalls of Combining Explanation and Normative Theory
Authors: Parsons Craig 
Published: November 2007

Erik Oddvar Eriksen and John Erik Fossum, eds., Democracy in the European Union (New York: Routledge, 2000)Dusan Sidjanski, The Federal Future of Europe: From the European Community to the European Union (Ann Arbor: Michigan University Press, 2000)
“Ein Staatsmann mit Geschichte”: Joschka Fischer's German Past
Authors: Sa'adah M. Anne 
Published: November 2007

Joschka Fischer (b. 1948), Germany’s foreign minister and for severalyears one of the country’s most popular politicians, is a man ofthe moment, of consequence both domestically and beyond hiscountry’s borders. Nationally prominent as leader of the “realo” factionof the Greens, he was instrumental in turning a protest movementinto the partner in power of the Social Democratic Party(SPD). During the Kosovo crisis, he was a key figure in securingGerman participation in the NATO intervention. He has played aninfluential role in the unfolding debate about institutional reformwithin the European Union. During the latest round of Israeli-Palestinianviolence, he has actively tried to bring the parties to the table.
Stars on the Screen, Strangers on the Streets
Authors: Hall Sara 
Published: November 2007

Jans B. Wager, Dangerous Dames. Women and Representation in the Weimar Street Film and Film Noir (Athens: Ohio University Press, 1999)Katharina von Ankum, ed., Women in the Metropolis: Gender and Modernity in Weimar Culture (Berkeley: University of California Press, 1997)
The GDR: Internal and External Constraints
Authors: Kopstein Jeffrey 
Published: November 2007

Gareth Pritchard, The Making of the GDR: From Anti-Fascism to Stalinism, 1945-1953 (Manchester and New York: Manchester University Press, 2000)M.E. Sarotte, Dealing with the Devil: East Germany and Ostpolitik, 1969-1973 (Chapel Hill and London: The University of North Carolina Press, 2001)
Clash Over Corporate Accountability and the Holocaust
Authors: Simpson Christopher 
Published: November 2007

The most deceitful aspect of Gerald Feldman’s commentary on mybook is his tacit claim that he is engaged in something other thancharacter assassination. As in other academic jihads he has pursued inthe past, Feldman’s most effective weapon has been his capacity forad hominem attack. Straightforward debate concerning disputed historicalevidence is considerably further down his list.
On Ethnic Essence and the Notion of German Victimization: Martin Walser and Asta Scheib’s Armer Nanosh and the Jew within the Gypsy
Authors: Margalit Gilad 
Published: November 2007

This article discusses a screenplay of the television thriller ArmerNanosh (Poor Nanosh), written in 19891 by the famous Germanauthor Martin Walser and Asta Scheib.2 The screenplay deals withthe relations between Germans and Germany’s Sinti, or Gypsy, populationin the shadow of Auschwitz,3 a subject that has hardly beentouched upon by postwar German authors and dramatists.
Parliamentary Control and Foreign Policy in Germany: The Bundestag’s Use of Formal, Instrumentalities in Overseeing the Administration’s Foreign Policy
Authors: Anderson James Ryan 
Published: November 2007

In a little more than a decade, Germany’s role in international affairs—particularly from a military perspective—has radically changed. WhereasGerman participation during the Persian Gulf War of 1991 wasbasically limited to providing financial support to the internationalcoalition led by the United States, by the end of 2001, German soldierswere operating under combat conditions in the United Nations peacekeepingmission to Afghanistan. During (and even before) this transition,little attention has been devoted to the German Bundestag’sconstitutional role as overseer of executive foreign affairs activities.
Immigration and German Cities: Exploring National Policies and Local Outcomes
Authors: Heisler Barbara Schmitter 
Published: November 2007

The presence of sizable foreign-born populations (which include citizensand non-citizens) in advanced industrial societies is the result ofnational policies on immigration, refugees, and labor migration. Theconsequences of these policies, however, are most visible at the locallevel, where newcomers work, settle, and raise their families. Whilenot all immigrants live in cities, they have been particularly concentratedin urban environments. Thus, it is hardly surprising that manyof the socioeconomic, cultural, and political issues and problemsassociated with immigration and the process of immigrant settlementare played out and magnified in cities.
In Search of a Future: Leipzig Since the Wende
Authors: Kolinsky Eva 
Published: November 2007

In the political and economic history of Germany, Leipzig alreadyheld a special place long before unification. Since the middle ages, ithas hosted one of the most important trade fairs in Europe. Whenindustrialization turned Germany in the late nineteenth century intoa leading European power, outpacing France and closely rivalingBritain, Leipzig added to its established and internationally acclaimedfur and book trade a mighty industrial sector in lignite-based chemicalsand vehicle production. At the turn of the century, Leipzig wasone of the largest and most affluent cities of Germany and indeedEurope. A rich stock of Gründerzeit houses remains to testify to thisillustrious past.
The New Berlin
Authors: Strom Elizabeth , Mayer Margit 
Published: November 2007

National and world events shape all cities, but in Berlin they have aphysical presence. For Berliners, the Cold War was tangible, manifestedas a wall and death strip guarded by armed soldiers and attackdogs. Today that wall is gone and, if national power brokers and thereal estate development community have their way, Berlin will soonbe a “normal” European city and German capital. Not only will theghosts of the Nazi past be exorcised, but any tangible inheritance ofthe postwar period—in East Berlin the legacies of state socialism, inWest Berlin the strange fruits of a subsidized economy—will disappear.
Integration and Political Representation in a Multicultural City: The Case of Frankfurt am Main
Authors: Klopp Brett 
Published: November 2007

Cities have long been the destination of those on the move. Migrationand especially immigration always raise issues of inclusion andexclusion, of rights and obligations, and of the meaning of membershipand citizenship. The particular form and content of thesedebates vary, just as host countries, national and local governments,and immigrant populations vary. Over the past few decades, patternsof immigration have begun to shift away from classical immigrationcountries (the United States, Canada, Australia) toward the democraciesof the European Union. “In this troubled world, WesternEurope has in fact, become a fragile island of prosperity, peace,democracy, culture, science, welfare and civil rights,” according tourban sociologist, Manuel Castells. “However, the selfish reflex oftrying to preserve this heaven by erecting walls against the rest ofthe world may undermine the very fundamentals of European cultureand democratic civilization, since the exclusion of the other isnot separable from the suppression of civil liberties and a mobilizationagainst alien cultures.”
Capitalist Futures and Socialist Legacies: Urban Development in East Germany Since 1990
Authors: Häußermann Hartmut 
Published: November 2007

Since unification, the political, economic, and institutional structuresin the new federal states have been patterned in accordance with theWest German model. This is due in part to the extension of theWestern legal framework to the eastern Länder. The fact that thepolitical and economic actors of the once-socialist country are nowsubject to the institutional conditions of the West encourages convergencetowards the western model. But questions have been raised asto whether the cities in the new federal states are also adaptingrapidly to the western model of urban development. Their layoutand architecture resulted, after all, from the investment decisionsmade by several generations and cannot be shifted or transformed asrapidly as legal or institutional frameworks.
A Celebration of Democracy: The 1998 Bundestag Election
Authors: Dalton Russell J. 
Published: November 2007

Free elections are celebrations of the democratic process, and theGermans celebrated in an unprecedented way on September 27,1998. After sixteen years of Christian Democratic rule, the publicused its democratic power to change the government. Indeed, for thefirst time in the history of the Federal Republic, voters rejected a sittingchancellor and chose a new government through the ballot box.