bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disponibilidad de inventarios frente a la demanda en productos de Tiendas TuTi
Authors: Zambrano-Ponce Angelica , Zaldumbide-Peralvo David 
Published: March 2024

El presente estudio expuso como finalidad determinar qué acciones estratégicas permitirán optimizar la gestión de inventarios de Tiendas TuTi. Esta empresa es un supermercado con modelo de negocio de hard discount, donde responde a la necesidad de ahorro que buscan los consumidores.
Dentro de la investigación se denota que este supermercado refleja una alta demanda de productos, por lo que es necesario llevar a cabo una adecuada gestión de inventario realizando un análisis de la situación actual y proponiendo medidas que garanticen mejoras en los procesos y reducción en los costos. Se consideran dos variables importantes, la demanda de productos como variable independiente y la gestión de inventarios como variable dependiente.
La investigación tiene un enfoque mixto, un diseño no experimental, de tipo descriptiva pues se base en investigaciones para caracterizar el tema en estudio; y exploratoria, al no contar con datos sobre la gestión de inventario. Se consideró una muestra de 341 personas, sobre las cuales se aplicó la encuesta.
Entre los resultados se puede evidenciar que el principal problema es la inadecuada gestión d inventario, pues el 67% indicó que diariamente se ven enfrentados a sobreinventario o desabastecimiento, siendo la demanda el primordial elemento para determinar niveles óptimos de stock, donde el 74% estuvo de acuerdo con esta afirmación, dado esto se requiere establecer estrategias para enfrentar esta problemática, por lo que el 43% mencionó que la alternativa más adecuada es realizar un control de inventarios.
El procedimiento de fiscalización y su impacto en la recaudación tributaria del impuesto a la renta de primera categoría de las personas naturales en el distrito de Los Olivos durante el periodo 2019
Authors: Miranda-Suel José 
Published: March 2024

El estudio tuvo como objetivo principal analizar el procedimiento de fiscalización y su relación con la recaudación tributaria específicamente en el ámbito del Impuesto a la Renta de Primera Categoría, con el objetivo de poder contribuir a que los peruanos tomen consciencia de la relevancia de pagar no solo el aludido tributo, sino todos respecto del cual se encuentren obligados, y con ello formar parte del desarrollo del país. El lector obtendrá conocimientos sobre el procedimiento de inspección tributaria, la recaudación de impuestos, el tema de la evasión fiscal, la falta de conciencia y/o cultura tributaria y los esfuerzos que realiza el Estado para abordar esta problemática. Además, se brindarán recomendaciones para mejorar la comprensión y el debate sobre nuestra responsabilidad de cumplir con nuestras obligaciones fiscales y la relevancia de reducir la evasión fiscal. Es nuestro deber como ciudadanos contribuir a esta causa.
El estudio ha sido de diseño no experimental y cuantitativo, de alcance descriptivo-correlacional y, la técnica usada fue la encuesta. La investigación se dirigió específicamente a las personas naturales obligadas al pago del Impuesto a la Renta de Primera Categoría, durante el periodo 2019. Especialmente, a los arrendadores de bienes inmuebles en dicha jurisdicción, entre los cuales, se eligió a 40 de ellos, a fin de obtener una muestra en aras de lograr los objetivos del trabajo.
La investigación confirma que el método de fiscalización incide directamente en la recaudación del impuesto sobre la renta de primera categoría de las personas naturales en el distrito de Los Olivos. En pocas palabras, una técnica de auditoría fiscal más eficaz conduce a un mayor beneficio en la recaudación del impuesto sobre la renta de primera categoría, y lo contrario también es cierto.
Análisis de la evolución de las exportaciones de rosas del Ecuador – Perú y su participación en los mercados internacionales en los años 2018 - 2022
Authors: Chichande-Torres Nayeli , Morán-Apolo Kelly , Enderica-Armijos Hermán , Pizarro-Romero Kelvin 
Published: March 2024

En el ámbito del comercio internacional, la floricultura se considera como una de las actividades agrícolas más destacadas en la producción de cultivos de alto valor, de manera que contribuye significativamente a la generación de empleo e ingresos, es por ello que las exportaciones de rosas cumplen un papel importante en la economía de los países, siendo factible para el ingreso de divisas, impulsando así el crecimiento económico comercial a largo plazo, dado a que las operaciones de exportación generan una gran contribución para el Producto Interno Bruto del mercado nacional. Sin embargo, las diversas circunstancias suscitadas entre los años 2018 al 2022, como los cambios climáticos, la falta de posicionamiento de las rosas en el mercado exterior, el alto grado de competitividad en los mercados internacionales, la pandemia por COVID-19 y el conflicto bélico entre Rusia y Ucrania​, han afectado al sector exportador de rosas, impactando directamente a la economía de los diferentes países. Es por ello que el artículo se realiza con la finalidad de describir la evolución de las exportaciones de rosas de Ecuador – Perú y su participación en los mercados internacionales en los años 2018 – 2022, observando el potencial de exportación y competitividad en los mercados internacionales. Para corroborar el rigor científico se utilizaron métodos teóricos, empíricos y estadísticos. Los resultados presentados indujeron a concluir que las exportaciones de rosas experimentaron varios cambios durante los cinco años, donde Ecuador tuvo un crecimiento significativo en el año 2022 con una participación del 23%, siendo el 2 mayor exportador de rosas en el mundo. Por lo tanto, en Perú las exportaciones evidencian un decrecimiento de ventas, posicionándose en el puesto número 55 con una participación del 0,2 % a escala mundial, donde las exportaciones de rosas ecuatorianas tienen una mayor participación, fomentando así el crecimiento económico del país.
PERAN PELEMBAGAAN DALAM PROGRAM ONE VILLAGE ONE PRODUCT MELALUI EMPOWERMENT MASYARAKAT
Authors: Dyah Ratnasari Siwi , Saikhu Akhmad , Sunarto Sunarto 
Published: March 2024

Â One village one product (OVOP) merupakan konsep pengembangan ekonomi yang mengarahkan suatu wilayah mampu menciptakan produk bercirikan lokal dengan potensi sumberdaya lokal dan berdaya saing global. Tujuan Penelitian adalah untuk mengetahui: 1) proses pelaksanaan OVOP sebagai upaya pemberdayaan ekonomi masyarakat 2) untuk mengetahui model pelembagaan yang digunakan dalam pelaksanaan program OVOP. Jenis penelitian adalah penelitian kualitatif. Penelitian dilakukan di Desa Sadengrejo Kecamatan Rejoso, Kabupaten Pasuruan. Metode yang digunakan berupa metode interractive model. Teknik pengumpulan data melalui wawancara dan dokumentasi. Tahapan penelitian meliputi: reduksi data, penyajian data dan penarikan kesimpulan (verifikasi). Hasil penelitian menunjukkan bahwa: 1) Proses pelaksanaan OVOP meliputi: a) Pemetaan potensi, b) Menemukan sasaran pada basis desa tertinggal, c) OVOP dikembangkan secara kelompok, d) Memilih potensi lokal, e) Mengembangkan potensi lokal, f) Menguatkan kelembagaan dengan konsep pemberdayaan, g) Membuat perencanaan usaha. 2) Model pelembagaan yang digunakan dalam pelaksanaan OVOP adalah kombinasi antara buttom up dan top down, meskipun feedback belum berjalan secara efektif. Implikasi dari penelitian ini adalah bahwa program OVOP yang telah dilaksanakan memerlukan monitoring dan evaluasi untuk perbaikan pelaksanaan kegiatan selanjutnya.Kata Kunci:Â Pelembagaan, Empowerment, One Village One Product (OVOP)Â Â Â Â Â Â Â Â Â Â Â Â One village one product (OVOP) is an economic development concept that directs a region to be able to create products with local characteristics with local resource potential and global competitiveness. The research objectives are to determine: 1) the process of implementing OVOP as an effort to empower the community's economy 2) to determine the institutional model used in the implementation of the OVOP program. This type of research is qualitative research. The research was conducted in Sadengrejo Village, Rejoso, Pasuruan. The method used is an interactive model method. Data collection techniques through interviews and documentation. The research stages include: data reduction, data presentation and conclusion drawing (verification). The results showed that: 1) The OVOP implementation process includes: a) Potential mapping, b) Finding targets on a disadvantaged village basis, c) OVOP is developed in groups, d) Selecting local potential, e) Developing local potential, f) Strengthening institutions by the concept of empowerment, g) Making business plans. 2) The institutional model used in the implementation of OVOP is a combination of bottom up and top down, although the feedback has not been effective. The implication of this research is that the OVOP program that has been implemented requires monitoring and evaluation to improve the implementation of further activities.Keywords:Â Community, Empowerment, One Village One Product (OVOP)
Tension band high-strength suture combined with absorbable cannulated screws for treating transverse patellar fractures: finite element analysis and clinical study
Authors: Xiang Feifan , Xiao Yukun , Li Dige , Ma Wenzhe , Chen Yue , Yang Yunkang 
Published: March 2024

Objective: Few reports exist on the treatment of transverse patellar fractures (TPFs) using absorbable cannulated screws and high-strength sutures, and most screws and sutures lack good biomechanics and clinical trials. Therefore, this study aimed to demonstrate the biomechanical stability and clinical efficacy of tension-band high-strength sutures combined with absorbable cannulated screws (TBSAS) in treating TPFs (AO/OTA 34 C1).Methods: Finite element models of five internal fixation schemes were established: tension-band wire with K-wire (TBW), TBW with cerclage wire (TBWC), TBW with headless pressure screws (TBWHS), TBW with full-thread screws (TBWFS), and TBSAS. We comprehensively compared the biomechanical characteristics of the TBSAS treatment scheme during knee flexion and extension. Forty-one patients with TPFs in our hospital between January 2020 and August 2022 were retrospectively enrolled and divided into the TBSAS (n = 22) and TBWC (n = 19) groups. Clinical and follow-up outcomes, including operative time, visual analog scale (VAS) pain score, postoperative complications, Bostman score, and final knee range of motion, were compared between both groups.Results: Finite element analysis (FEA) showed that TBWHS and TBWFS achieved the minimum mean fracture interface relative displacement during knee flexion (45°, 0–500 N bending load) and full extension (0°, 0–500 N axial load). There was no significant difference between TBSAS (0.136 mm) and TBWC (0.146 mm) during knee flexion (500 N); however, TBSAS displacement was smaller (0.075 mm) during full extension (500 N). Furthermore, the stress results for the internal fixation and the patella were generally lower when using TBSAS. Retrospective clinical studies showed that the TBSAS group had a shorter operative time, lower VAS pain score at 1 and 2 months postoperatively, better Bostman knee function score at 3 and 9 months postoperatively, and better final knee joint motion than the TBWC group (all p &lt; 0.05). There were five cases (26.3%) of internal fixation stimulation complications in the TBWC group.Conclusion: TBSAS demonstrated excellent safety and effectiveness in treating TPFs. It is sufficient to meet the needs of TPF fixation and early functional exercise and effectively reduces metal internal fixation-induced complications and secondary surgery-induced trauma.
Sonotope patterns within a mountain beech forest of Northern Italy: a methodological and empirical approach
Authors: Farina Almo , Mullet Timothy C. 
Published: March 2024

According to the Sonotope Hypothesis, the heterogenous nature of the acoustically sensed, but not yet interpreted, environmental sounds (i.e., sonoscape) is created by the spatial and temporal conformation of sonic patches (sonotopes) as recently been described in a Mediterranean rural landscape. We investigated the Sonotope Hypothesis in a mountain beech forest of the Northern Apennines, Italy that is notoriously poor in soniferous species. Our aim was to test whether sonotopes were temporally distinct over seasonal and astronomical timeframes and spatially configured in relation to vegetation variables. We used the Acoustic Complexity Index (ACItf) to analyze the heterogeneity of sonic information gathered from an array of 11 sound recorders deployed within a lattice of eleven 4-ha hexagonal sample sites distributed throughout a 48-ha managed beech forest. We visualized and described the temporal patterns of ACItf between seasons (May–June and July–August 2021), across six astronomical periods (Night I, Morning Twilight, Morning, Afternoon, Evening Twilight, and Night II), and according to two aggregated frequency classes (≤2000 and &gt;2000 Hz). We introduced Spectral Sonic Signature (SSS) calculated from the sequence of ACItf values along frequency bins as a descriptor of the dynamic production of sounds across spatial and temporal scales. We calculated Mean Spectral Dissimilarity to compare SSS values across temporal periods and between sample sites. We identified sonotopes by grouping similar SSS for each sample site generated from cluster analyses and visualized their spatial arrangements. Frequencies ≤2000 Hz (mainly geophonies from wind and rain) were more prevalent than frequencies &gt;2000 Hz (mainly biophonies from songbirds). Despite there being no strong relationship to vegetation variables and minimal biophony and anthropophony, distinct sonotopes still emerged for every astronomical and seasonal period. This suggests that the sonoscape expresses distinct spatial and temporal sonotope configurations associated with the temporal and spatial patterns of geophysical events that generate geophonies with minimal animal or anthropogenic occurrences. A new strategy based on the reintroduction of indigenous trees and shrubs in managed clearings should be considered for enhancing local biodiversity conservation along with ecoacoustic monitoring based on the Sonotope Hypothesis.
CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production
Authors: Na Kwangmin , Lee Seul , Kim Dong Kwon , Kim Young Seob , Hwang Joon Yeon , Kang Seong-san , Baek Sujeong , Lee Chai Young , Yang Seung Min , Han Yu Jin , Kim Mi hyun , Han Heekyung , Kim Youngtaek , Kim Jae Hwan , Jeon Seunghyun , Byeon Youngseon , Lee Jii Bum , Lim Sun Min , Hong Min Hee , Pyo Kyoung-Ho , Cho Byoung Chul 
Published: March 2024

IntroductionTo understand the immune system within the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC), it is crucial to elucidate the characteristics of molecules associated with T cell activation.MethodsWe conducted an in-depth analysis using single-cell RNA sequencing data obtained from tissue samples of 19 NSCLC patients. T cells were classified based on the Tumor Proportion Score (TPS) within the tumor region, and molecular markers associated with activation and exhaustion were analyzed in T cells from high TPS areas.ResultsNotably, tetraspanins CD81 and CD82, belonging to the tetraspanin protein family, were found to be expressed in activated T cells, particularly in cytotoxic T cells. These tetraspanins showed strong correlations with activation and exhaustion markers. In vitro experiments confirmed increased expression of CD81 and CD82 in IL-2-stimulated T cells. T cells were categorized into CD81highCD82high and CD81lowCD82low groups based on their expression levels, with CD81highCD82high T cells exhibiting elevated activation markers such as CD25 and CD69 compared to CD81lowCD82low T cells. This trend was consistent across CD3+, CD8+, and CD4+ T cell subsets. Moreover, CD81highCD82high T cells, when stimulated with anti-CD3, demonstrated enhanced secretion of cytokines such as IFN-γ, TNF-α, and IL-2, along with an increase in the proportion of memory T cells. Bulk RNA sequencing results after sorting CD81highCD82high and CD81lowCD82low T cells consistently supported the roles of CD81 and CD82. Experiments with overexpressed CD81 and CD82 showed increased cytotoxicity against target cells.DiscussionThese findings highlight the multifaceted roles of CD81 and CD82 in T cell activation, cytokine production, memory subset accumulation, and target cell cytolysis. Therefore, these findings suggest the potential of CD81 and CD82 as promising candidates for co-stimulatory molecules in immune therapeutic strategies for cancer treatment within the intricate TME.
Identification of novel hub genes for Alzheimer’s disease associated with the hippocampus using WGCNA and differential gene analysis
Authors: Chen Yang , Li Zhaoxiang , Ge Xin , Lv Huandi , Geng Zuojun 
Published: March 2024

BackgroundAlzheimer’s disease (AD) is a common, refractory, progressive neurodegenerative disorder in which cognitive and memory deficits are highly correlated with abnormalities in hippocampal brain regions. There is still a lack of hippocampus-related markers for AD diagnosis and prevention.MethodsDifferently expressed genes were identified in the gene expression profile GSE293789 in the hippocampal brain region. Enrichment analyses GO, KEGG, and GSEA were used to identify biological pathways involved in the DEGs and AD-related group. WGCNA was used to identify the gene modules that are highly associated with AD in the samples. The intersecting genes of the genes in DEGs and modules were extracted and the top ten ranked hub genes were identified. Finally GES48350 was used as a validation cohort to predict the diagnostic efficacy of hub genes.ResultsFrom GSE293789, 225 DEGs were identified, which were mainly associated with calcium response, glutamatergic synapses, and calcium-dependent phospholipid-binding response. WGCNA analysis yielded dark green and bright yellow modular genes as the most relevant to AD. From these two modules, 176 genes were extracted, which were taken to be intersected with DEGs, yielding 51 intersecting genes. Then 10 hub genes were identified in them: HSPA1B, HSPB1, HSPA1A, DNAJB1, HSPB8, ANXA2, ANXA1, SOX9, YAP1, and AHNAK. Validation of these genes was found to have excellent diagnostic performance.ConclusionTen AD-related hub genes in the hippocampus were identified, contributing to further understanding of AD development in the hippocampus and development of targets for therapeutic prevention.
An investigation into the potential association between nutrition and Alzheimer’s disease
Authors: He Mingyue , Lian Tenghong , Liu Zhan , Li Jinghui , Qi Jing , Li Jing , Guo Peng , Zhang Yanan , Luo Dongmei , Guan Huiying , Zhang Weijia , Zheng Zijing , Yue Hao , Zhang Wenjing , Wang Ruidan , Zhang Fan , Zhang Wei 
Published: March 2024

BackgroundMalnutrition is the most common nutritional issue in Alzheimer’s disease (AD) patients, but there is still a lack of a comprehensive evaluation of the nutritional status in AD patients. This study aimed to determine the potential association of various nutritional indices with AD at different stages.MethodsSubjects, including individuals with normal cognition (NC) and patients diagnosed with AD, were consecutively enrolled in this cross-sectional study. Demographics, body composition, dietary patterns, nutritional assessment scales and nutrition-related laboratory variables were collected. Binary logistics regression analyses and receiver operating characteristic (ROC) curves were used to indicate the association between nutrition-related variables and AD at different stages.ResultsTotals of 266 subjects, including 73 subjects with NC, 72 subjects with mild cognitive impairment due to AD (AD-MCI) and 121 subjects with dementia due to AD (AD-D) were included. There was no significant difference in dietary patterns, including Mediterranean diet and Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet between the three groups. Lower BMI value, smaller hip and calf circumferences, lower Mini Nutritional Assessment (MNA) and Geriatric Nutritional Risk Index (GNRI) scores, and lower levels of total protein, albumin, globulin, and apolipoprotein A1 were associated with AD (all p &lt; 0.05). Total protein and albumin levels had the greatest ability to distinguish AD from non-AD (AUC 0.80, 95% CI 0.74–0.84, p &lt; 0.001), increased by combining calf circumference, MNA score and albumin level (AUC 0.83, 95% CI 0.77–0.88, p &lt; 0.001). Albumin level had the greatest ability to distinguish NC from AD-MCI (AUC 0.75, 95% CI 0.67–0.82, p &lt; 0.001), and MNA score greatest ability to distinguish AD-MCI from AD-D (AUC 0.72, 95% CI 0.65–0.78, p &lt; 0.001).ConclusionNutritional status of AD patients is significantly compromised compared with normal controls, and tends to be worsened with AD progresses. Early identification and intervention of individuals with nutritional risk or malnutrition may be significantly beneficial for reducing the risk, development, and progression of AD.
When do drugs trigger criminal behavior? a machine learning analysis of offenders and non-offenders with schizophrenia and comorbid substance use disorder
Authors: Bender Ewa-Maria , Machetanz Lena , von Känel Roland , Euler Sebastian , Kirchebner Johannes , Günther Moritz Philipp 
Published: March 2024

IntroductionComorbid substance use disorder (SUD) is linked to a higher risk of violence in patients with schizophrenia spectrum disorder (SSD). The objective of this study is to explore the most distinguishing factors between offending and non-offending patients diagnosed with SSD and comorbid SUD using supervised machine learning.MethodsA total of 269 offender patients and 184 non-offender patients, all diagnosed with SSD and SUD, were assessed using supervised machine learning algorithms.ResultsFailures during opening, referring to rule violations during a permitted temporary leave from an inpatient ward or during the opening of an otherwise closed ward, was found to be the most influential distinguishing factor, closely followed by non-compliance with medication (in the psychiatric history). Following in succession were social isolation in the past, no antipsychotics prescribed (in the psychiatric history), and no outpatient psychiatric treatments before the current hospitalization.DiscussionThis research identifies critical factors distinguishing offending patients from non-offending patients with SSD and SUD. Among various risk factors considered in prior research, this study emphasizes treatment-related differences between the groups, indicating the potential for improvement regarding access and maintenance of treatment in this particular population. Further research is warranted to explore the relationship between social isolation and delinquency in this patient population.