bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring and Discussing Health-Related Quality of Life in Adolescents With Type 1 Diabetes Improve Psychosocial Well-Being
Authors: de Wit Maartje , Delemarre-van de Waal Henriette A. , Bokma Jan Alle , Haasnoot Krijn , Houdijk Mieke C. , Gemke Reinoud J. , Snoek Frank J. 
Published: June 2008

OBJECTIVE—To test the effects of monitoring and discussing of health-related quality of life (HRQoL) in adolescents with type 1 diabetes in a multicenter randomized controlled trial.
RESEARCH DESIGN AND METHODS—Four centers were randomly assigned to the HRQoL intervention (46 adolescents) or control (45 adolescents) group, with three regular visits scheduled within 12 months in both groups. In the HRQoL intervention group, HRQoL of adolescents was assessed using the Pediatric Quality of Life Inventory, and outcomes were discussed face-to-face during the consultation. The control group received care as usual. Mean differences between the groups at 12 months in physical and psychosocial well-being (Child Health Questionnaire [CHQ]-CF87/PF50, Diabetes-Specific Family Conflict Scale, and Center for Epidemiological Studies Scale for Depression), satisfaction with care (Patients’ Evaluation of the Quality of Diabetes Care), and A1C were determined, controlling for baseline scores.
RESULTS—Mean scores on the CHQ subscales of psychosocial health (P &lt; 0.001), behavior (P &lt; 0.001), mental health (P &lt; 0.001), and family activities (P &lt; 0.001) improved in the HRQoL intervention group, except for adolescents with the highest A1C values. Adolescents in the HRQoL intervention group reported higher self-esteem (CHQ) at follow-up (P = 0.016), regardless of A1C, and were more satisfied with care (P = 0.009) than control subjects. No significant differences between the two groups over time were observed in A1C levels.
CONCLUSIONS—Periodic monitoring and discussion of HRQoL in adolescents with diabetes is appreciated and has positive effects on their psychosocial well-being, except for those in poorest control.
Genetic Determinants and Epidemiology of Cystic Fibrosis–Related Diabetes
Authors: Adler Amanda I. , Shine Brian S.F. , Chamnan Parinya , Haworth Charles S. , Bilton Diana 
Published: June 2008

OBJECTIVE—Longer survival of patients with cystic fibrosis has increased the occurrence of cystic fibrosis–related diabetes (CFRD). In this study we documented the incidence of CFRD and evaluated the association between mutations responsible for cystic fibrosis and incident CFRD, while identifying potential risk factors.
RESEARCH DESIGN AND METHODS—This was a population-based longitudinal study of 50 cystic fibrosis speciality clinics in the U.K. Subjects included 8,029 individuals aged 0–64 years enrolled in the U.K. Cystic Fibrosis Registry during 1996–2005. Of these, 5,196 with data and without diabetes were included in analyses of incidence, and 3,275 with complete data were included in analyses of risk factors. Diabetes was defined by physician diagnosis, oral glucose tolerance testing, or treatment with hypoglycemic drugs.
RESULTS—A total of 526 individuals developed CFRD over 15,010 person-years. The annual incidence was 3.5%. The incidence was higher in female patients and in patients with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene in classes I and II. In a multivariate model of 377 cases of 3,275 patients, CFTR class (relative risk 1.70 [95% CI 1.16–2.49], class I or II versus others), increasing age, female sex, worse pulmonary function, liver dysfunction, pancreatic insufficiency, and corticosteroid use were independently associated with incident diabetes.
CONCLUSIONS—The incidence of CFRD is high in Britain. CFTR class I and II mutations increase the risk of diabetes independent of other risk factors including pancreatic exocrine dysfunction.
Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
Authors: Hammer Sebastiaan , Jonker Jacqueline T. , Lamb Hildo J. , van der Meer Rutger W. , Zondag Wendy , Sepers Jan M. , de Roos Albert , Smit Johannes W.A. , Romijn Johannes A. 
Published: June 2008

OBJECTIVE—To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes.
RESEARCH DESIGN AND METHODS—Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10).
RESULTS—Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 h, P &lt; 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P &lt; 0.001), and plasma levels of nonesterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function.
CONCLUSIONS—Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.
Oxidation, Type 2 Diabetes, and Coronary Heart Disease: A Complex Interaction
Authors: Stranges Saverio , Dorn Joan M. , Donahue Richard P. , Browne Richard W. , Freudenheim Jo L. , Hovey Kathleen M. , Trevisan Maurizio 
Published: June 2008

OBJECTIVE—The purpose of this study was to analyze the interrelationship among oxidation, myocardial infarction (MI), and type 2 diabetes in a population-based case-control study of MI.
RESEARCH DESIGN AND METHODS—Participants were 1,709 individuals from western New York: 257 women and men with incident MI and 1,452 healthy control subjects (aged 35–70 years). Lipid peroxidation was measured by plasma levels of thiobarbituric acid reactive substances (TBARS). History of type 2 diabetes was determined by self-reported history of medical diagnosis.
RESULTS—In multivariate analyses, there was no significant difference in TBARS levels between case and control subjects in both sexes. In subgroup analyses by diabetes status, diabetic subjects, regardless of MI status, exhibited significantly higher TBARS values than nondiabetic subjects. For diabetic women, TBARS values were 1.84 and 1.83 nmol/ml for case and control subjects, respectively. Values for nondiabetic women were 1.29 and 1.31 nmol/ml, respectively. In diabetic men, values were 1.65 and 1.97 nmol/ml for case and control subjects, respectively. Values for nondiabetic men were 1.36 and 1.36 nmol/ml, respectively.
CONCLUSIONS—Whereas type 2 diabetes may be an important correlate of lipid peroxidation, clinical coronary heart disease may not.
Association Between Parental History of Type 2 Diabetes and Glycemic Control in Urban African Americans
Authors: Gong Lucy , Kao Wen Hong Linda , Brancati Frederick L. , Batts-Turner Marian , Gary Tiffany L. 
Published: June 2008

OBJECTIVE—The purpose of this study was to examine the association between parental history of type 2 diabetes and glycemic control among diabetic urban African Americans.
RESEARCH DESIGN AND METHODS—Study participants included 359 African Americans with type 2 diabetes from Baltimore, Maryland, enrolled in Project Sugar 2. Participants underwent an interview-administrated questionnaire that asked about family history, sociodemographics, clinical characteristics, and knowledge and perception of adequate glycemic control. Regression analysis was used to determine the association between parental history of diabetes and glycemic control, as measured by A1C.
RESULTS—In the comparisons between participants with and without a parental history of diabetes, those with a positive parental history tended to be younger, have higher glucose levels, and have higher blood glucose levels before calling a doctor (all P &lt; 0.05). After adjustments for age, sex, and BMI, there was a significant association (P = 0.02) between A1C and parental history with the mean A1C difference between those with a positive and a negative parental history being 0.58%. However, after adjustment for duration of diabetes, the association was no longer significant (P = 0.11). However, there was a tendency for individuals with two diabetic parents to have higher A1C (P = 0.011).
CONCLUSIONS—From these results, we conclude that among the urban African American participants who were aware of their parental history of diabetes, a positive parental history was associated with worse glycemic control, partly due to longer duration of diabetes. Parental history did not appear to be associated with better knowledge or perception of adequate glycemic control.
Dysglycemia and a History of Reproductive Risk Factors
Authors: McDonald Sarah D. , Yusuf Salim , Sheridan Patrick , Anand Sonia S. , Gerstein Hertzel C. ,   for the DREAM Trial Investigators
Published: June 2008

OBJECTIVE—The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population.
RESEARCH DESIGN AND METHODS—We studied 14,661 women screened with an oral glucose tolerance test for the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication (DREAM) trial. Reproductive risk factors were compared in normoglycemic and dysglycemic women.
RESULTS—Dysglycemia was significantly associated with the number of children born (odds ratio 1.03 per child [95% CI 1.01–1.05]), age (1.05 per year [1.04–1.05]), non-European ancestry (1.09 [1.01–1.17]), preeclampsia/eclampsia (1.14 [1.02–1.27]), irregular periods (1.21 [1.07–1.36]), and gestational diabetes mellitus (GDM) (1.53 [1.35–1.74]). The relationship between GDM and dysglycemia did not differ across BMI tertiles (P = 0.84) nor did the relationships of other risk factors.
CONCLUSIONS—Reproductive factors, particularly GDM, are associated with dysglycemia in middle-aged women from many ethnicities. Reproductive factors can be used to counsel young women about their future risk of dysglycemia, whereas in middle age they may help screen for dysglycemia.
Health Care Use and Costs Associated With Use of a Health Club Membership Benefit in Older Adults with Diabetes
Authors: Nguyen Huong Q. , Maciejewski Matthew L. , Gao Sue , Lin Elizabeth , Williams Barbara , LoGerfo James P. 
Published: June 2008

OBJECTIVE—The purpose of this study was to determine whether elective use of a health plan–sponsored health club membership had an impact on health care use and costs among older adults with diabetes.
RESEARCH DESIGN AND METHODS—Administrative claims for 2,031 older adults with diabetes enrolled in a Medicare Advantage plan were obtained for this retrospective cohort study. Participants (n = 618) in the plan-sponsored health club benefit (Silver Sneakers [SS]) and control subjects (n = 1,413) matched on SS enrollment index date were enrolled in the plan for at least 1 year before the index date. Two-year health care use and costs of SS participants and control subjects were estimated in regressions adjusting for baseline differences.
RESULTS—SS participants were more likely to be male, had a lower chronic disease burden, used more preventive services, and had a lower prevalence of arthritis (P ≤ 05). SS participants had lower adjusted total health care costs than control subjects in the first year after enrollment (−$1,633 [95% CI −$2,620 to −$646], P = 0.001), and adjusted total costs in year 2 trended lower (−$1,230 [−$2,494 to $33], P = 0.06). Participants who made on average ≥2 SS visits/week in year 1 had lower total costs in year 2 ($2,141 [−$3,877 to −$405], P = 0.02) than participants who made &lt;2 visits/week.
CONCLUSIONS—Use of a health club benefit by older adults with diabetes was associated with slower growth in total health care costs over 2 years; greater use of the benefit was actually associated with declines in total costs.
Progression of Cardiovascular Autonomic Dysfunction in Patients With Type 2 Diabetes
Authors: Ko Seung-Hyun , Park Shin-Ae , Cho Jae-Hyoung , Song Ki-Ho , Yoon Kun-Ho , Cha Bong-Yun , Son Ho-Young , Yoo Ki-Dong , Moon Keon-Woong , Park Yong-Moon , Ahn Yu-Bai 
Published: June 2008

OBJECTIVE—We investigated whether cardiovascular autonomic dysfunction was associated with glycemic control status over time in patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS—From 1999 to 2000, cardiovascular autonomic nerve function testing (AFT) was performed on patients with type 2 diabetes (n = 1,021) and was followed-up in 2006 and February 2008. Tests for cardiovascular autonomic functions measured heart rate variability parameters (expiration-to-inspiration [E/I] ratio, responses to the Valsalva maneuver, and standing). AFT scores were determined from the results of the each test as follows: 0 for normal and 1 for abnormal. We began with those who had a score of 0 and assessed the changes in total score along with biannual A1C levels.
RESULTS—At follow-up, the development of cardiovascular autonomic dysfunction was 34.5% (E/I ratio 21.9%, Valsalva maneuver 77.8%, and posture 58.9%; n = 783). The development of cardiovascular autonomic dysfunction was higher in older patients (P &lt; 0.001); in those with longer duration of diabetes (P &lt; 0.001); of hypertension (P = 0.005), and of diabetic retinopathy (P &lt; 0.001); and in those who had higher levels of microalbuminuria (P = 0.002). Logistic regression analysis revealed that the development of cardiovascular autonomic dysfunction was strongly associated with the mean A1C level during the follow-up period (mean A1C &gt;9.0% vs. ≤7.0%, odds ratio 2.984, 95% CI 1.177–7.561; P = 0.021).
CONCLUSIONS—The development of cardiovascular autonomic dysfunction was independently associated with microvascular complications and glycemic control status during this 7.5-year follow-up in patients with type 2 diabetes.
Increased Risk of Cardiovascular Disease in Young Women Following Gestational Diabetes Mellitus
Authors: Shah Baiju R. , Retnakaran Ravi , Booth Gillian L. 
Published: June 2008

OBJECTIVE—To determine whether women with gestational diabetes mellitus (GDM) have an increased risk of cardiovascular disease (CVD) following pregnancy.
RESEARCH DESIGN AND METHODS—All women aged 20–49 years with live births between April 1994 and March 1997 in Ontario, Canada, were identified. Women with GDM were matched with 10 women without GDM and were followed for CVD.
RESULTS—The matched cohorts included 8,191 women with GDM and 81,262 women without GDM. Mean age at entry was 31 years, and median follow-up was 11.5 years. The hazard ratio for CVD events was 1.71 (95% CI 1.08–2.69). After adjustment for subsequent type 2 diabetes, the hazard ratio was attenuated (1.13 [95% CI 0.67–1.89]).
CONCLUSIONS—Young women with GDM had a substantially increased risk for CVD compared with women without GDM. Much of this increased risk was attributable to subsequent development of type 2 diabetes.
The identification and characterization of a new GTP-binding protein (Gbp45) involved in cell proliferation and death related to mitochondrial function
Authors: Kira Yukimi , Nishikawa Manabu 
Published: June 2008

AbstractWe describe the identification and characterization of a GTP-binding protein with a molecular weight of 45 kD (Gbp45). Gbp45 cDNA was found to overlap with a hypothetical human protein, PTD004, the sequence of which was previously deposited in the databases. The gene for PTD004 was recently found to be one of the ATPases, hOLA1 (human Obg-like ATPase 1). The Gbp45 gene encodes a protein of 396 amino acid residues. Immunocytochemical analysis and examination with GFP-tagged protein revealed that Gbp45 is primarily located in the cytosolic compartment. Immunoblot analysis showed that the Gbp45 protein is strongly expressed in the neuronal tissues and pancreas. T43N and T56N mutations resulted in a loss of Gbp45’s ability to bind to GTP and a loss of GTPase activity. In cultured cells, the transfection of wild-type Gbp45 accelerated cell proliferation, though T43N and T56N mutations induced cell death. Down-regulating Gbp45 expression decreased the cell proliferation rate and increased the rate of cell death induced by the inhibition of mitochondrial electron transport. These findings indicate that Gbp45 plays important roles in cell proliferation and death related to mitochondrial function.
Enhanced Osteoblast Adhesion to Epoxide‐Functionalized Surfaces
Authors: Trimbach David C. , Keller Brandis , Bhat Rahila , Zankovych Sergiy , Pöhlmann Rüdiger , Schröter Siegmund , Bossert Jörg , Jandt Klaus D. 
Published: June 2008

AbstractAs an alternative to expensive extracellular matrix (ECM) proteins generally applied as coatings in Petri dishes used for cell binding, an innovative system based on epoxide‐functionalized monolayers capable of protein binding is proposed. Since cells bind to material surfaces through proteins, protein‐binding surfaces should also promote cell binding. Here we investigate how the cell‐binding properties of an epoxide‐functionalized surface compares with ECM protein gel coated surfaces and tissue culture polystyrene control surfaces. Glass surfaces are functionalized with glycidoxypropyltriethoxysilane (GOPS), which results in an epoxide‐functionalized surface capable of binding proteins through an epoxide–amine reaction. Advancing contact angle measurements and atomic force microscopy measurements confirm the formation of a homogeneous GOPS monolayer. This monolayer is micropatterned with fluorescein‐labeled ECM protein gel by microcontact printing (µCP). Confocal laser scanning microscopy (CLSM) shows accurately transferred ECM protein gel micropatterns. Osteoblasts that are seeded on these micropatterned substrates show a clear preference for adhering to the epoxide‐functionalized areas. The morphology of these cultured osteoblasts is needle‐like with high aspect ratios. As controls, osteoblasts are cultured on GOPS‐functionalized surfaces, unstructured ECM protein gel surfaces, and tissue culture polystyrene (TCPS). The GOPS surfaces demonstrate a drastic increase in cell adhesion after 2 h, whilst the other tests show no adverse effects of this surface on the osteoblasts as compared to ECM and TCPS. CLSM shows healthy cell morphologies on each surface. It is demonstrated for the first time that epoxide groups outperform ECM protein gel in cell adhesion, thereby providing new routes for cost‐effective coatings that improve biocompatibility as well as exciting, new methodologies to control and direct cell adhesion.
Tandem Epoxidation‐Alcoholysis or Epoxidation‐Hydrolysis of Glycals Catalyzed by Titanium(IV) Isopropoxide or Venturello’s Phosphotungstate Complex
Authors: Levecque Pieter , Gammon David W. , Kinfe Henok Hadgu , Jacobs Pierre , De Vos Dirk , Sels Bert 
Published: June 2008

AbstractVenturello’s phosphotungstate complex and titanium(IV) isopropoxide [Ti(O‐i‐Pr)4] were successfully used as catalysts for the epoxidation‐alcoholysis of glycals using hydrogen peroxide [H2O2]. Reaction substrates included a range of variously protected glycals and different alcohols were used as solvents. Ti(O‐i‐Pr)4 was only effective in methanol as solvent, but gave methyl glycosides in high yields and high selectivities. The Venturello complex proved to be a very versatile and efficient catalyst. Apart from epoxidation‐alcoholysis in alcoholic solvents it also showed activity in biphasic conditions to allow for glycosylation of long‐chain alcohols and was very effective in the stereoselective dihydroxylation of benzylated glucal.
Synthesis and properties of silica–polyimide hybrid films derived from colloidal silica particles and polyamic acid
Authors: Shang Zhenping , Lü Changli , Lü Xiaodan , Gao Lianxun 
Published: June 2008

AbstractA series of SiO2/polyimide hybrid films with different contents and sizes of SiO2 particles were prepared by blending polyamic acid (PAA) and SiO2 nanoparticles obtained from Stöber method, followed by a step thermal imidization process. The size and content effect of SiO2 particles on the mechanical and thermal properties was studied. It was found that as the silica particles were introduced into polyimide matrix, Tgs of hybrid films increased on the whole and there was a maximum value of Tg for the hybrid film with 10‐nm SiO2 particles. TGA indicated that the thermal stability for hybrid films decreased with the increasing content and size of SiO2 particles. Dynamic mechanical thermal analysis (DMTA) indicated that the modulus of hybrid films increased, while the tensile strength and elongation at break decreased as the size of SiO2 particles increases from 10 to 25 nm and to 65 nm. All polyimide hybrid films were amorphous according to X‐ray determination. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Investigation into the flame retardant properties of soybean fabric treated with sulphamic acid
Authors: Vynias D. , Carr C. M. 
Published: June 2008

AbstractThe effect of sulfamic acid and urea treatments on the flame retardant properties of soybean fabric has been investigated by Limiting Oxygen Index (L.O.I.), Thermogravimetric Analysis (TGA), and X‐ray Photoelectron Spectroscopy (XPS) in order to characterize both the bulk and surface properties. The sulfamic acid finish significantly reduced the soybean fabric flammability and appeared to function in the solid phase with increased char formation. Incorporation of urea into the formulation increased the level of reaction and associated weight gain. However, the wash durability of the sulfamic acid modification of the soybean fabric was limited, but after treatment with a cationic fixing agent, Matexil FC‐ER significantly increased the wash fastness and related flame retardant effect. XPS analysis demonstrated the substantivity of the cationic fixing agent to soybean fiber surface and its binding effect on the sulfamate at the fiber surface. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Synthesis and characterization of poly(methyl methacrylate) nanoparticles by emulsifier‐free emulsion polymerization with a redox‐initiated system
Authors: Chiu Tso‐Pei , Don Trong‐Ming 
Published: June 2008

AbstractIn this study, the emulsifier‐free emulsion polymerization of methyl methacrylate (MMA) was initiated directly by a Cu2+/HSO redox system. Latex particles with negative charge due to the bonded anionic sulfite ion were successfully synthesized after 2 h of reaction at 40–60°C. Scanning electron microscopy pictures showed a uniform particle size distribution, and the average size decreased from 223 to 165 nm wit increasing reaction temperature from 40 to 60°C. The initiation step in the polymerization mechanism was proven to be a redox reaction, in which Cu2+ oxidized the bisulfite ion to produce an anionic sulfite radical and proton. The produced anionic sulfite radical then initiated the polymerization of MMA. Moreover, Cu2+ not only served as one component in the redox initiator system but also as a chain‐transfer agent that terminated growing polymer chains to produce chains with unsaturated end groups [poly(methyl methacrylate) (PMMA)CHCH2]. For this system, about 17% PMMACHCH2 was produced. The tacticities of the PMMA latex prepared at 40–60°C were almost the same, about 62–64% syndiotactic, 33–35% heterotactic, and 3% isotactic. These PMMA latexes had almost the same glass‐transition temperature, 125–127°C, regardless of the reaction temperatures, and their weight‐average molecular weights were in the range between 254,000 and 315,000. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008