bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal role of immune cells in obstructive sleep apnea hypopnea syndrome: Mendelian randomization study
Authors: Zhao Huang-Hong , Ma Zhen , Guan Dong-Sheng 
Published: February 2024

BACKGROUND
Despite being one of the most prevalent sleep disorders, obstructive sleep apnea hypoventilation syndrome (OSAHS) has limited information on its immunologic foundation. The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies (GWAS) and genotyping techniques using high-density genetic markers (e.g. , SNP or CNVs). But this tactic hasn't yet been applied to OSAHS. Using a Mendelian randomization analysis, we analyzed the causal link between immune cells and the illness in order to comprehend the immunological bases of OSAHS.
AIM
To investigate the immune cells' association with OSAHS via genetic methods, guiding future clinical research.
METHODS
A comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and OSAHS. Summary statistics for each immune cell feature were obtained from the GWAS catalog. Information on 731 immune cell properties, such as morphologic parameters, median fluorescence intensity, absolute cellular, and relative cellular, was compiled using publicly available genetic databases. The results' robustness, heterogeneity, and horizontal pleiotropy were confirmed using extensive sensitivity examination.
RESULTS
Following false discovery rate (FDR) correction, no statistically significant effect of OSAHS on immunophenotypes was observed. However, two lymphocyte subsets were found to have a significant association with the risk of OSAHS: Basophil %CD33dim HLA DR- CD66b- (OR = 1.03, 95%CI = 1.01-1.03, P < 0.001); CD38 on IgD+ CD24- B cell (OR = 1.04, 95%CI = 1.02-1.04, P = 0.019).
CONCLUSION
This study shows a strong link between immune cells and OSAHS through a gene approach, thus offering direction for potential future medical research.
Safety and efficacy comparison of remimazolam and propofol for intravenous anesthesia during gastroenteroscopic surgery of older patients: A meta-analysis
Authors: Li Fang-Zhuo , Zhao Cheng , Tang Yi-Xun , Liu Ji-Tong 
Published: February 2024

BACKGROUND
Remimazolam is characterized by rapid action and inactive metabolites. It is used as the general anesthetic for many clinical surgeries. In this study, we performed a meta-analysis to evaluate whether remimazolam is superior to propofol for gastroenteroscopy in older patients.
AIM
To compare the adverse events and efficacy of remimazolam and propofol during gastroenteroscopy in older adults.
METHODS
The PubMed, Web of Science, the Cochrane Library databases were queried for the relevant key words "remimazolam,” "and propofol,” "and gastrointestinal endoscopy or gastroscopy.” The search scope was "Title and Abstract,” and the search was limited to human studies and publications in English. Seven studies wherein remimazolam and propofol were compared were included for the meta-analysis.
RESULTS
We selected seven randomized controlled trials involving 1445 cases for the analysis. Remimazolam reduced the hypotension (relative risk, RR = 0.44, 95%CI: 0.29-0.66, P = 0.000), respiratory depression (RR = 0.46, 95%CI: 0.30-0.70, P = 0.000), injection pain (RR = 0.12, 95%CI: 0.05-0.25, P = 0.000), bradycardia (RR = 0.37, 95%CI: 0.24-0.58, P = 0.000), and time to discharge [weighted mean difference (WMD) = -0.58, 95%CI: -0.97 to -0.18, P = 0.005], compared to those after propofol administration. No obvious differences were observed for postoperative nausea and vomiting (RR = 1.09, 95%CI: 0.97-1.24, P = 0.151), dizziness (RR = 0.77, 95%CI: 0.43-1.36, P = 0.361), successful sedation rate (RR = 0.96, 95%CI: 0.93-1.00, P = 0.083), or the time to become fully alert (WMD = 0.00, 95%CI: -1.08-1.08, P = 0.998).
CONCLUSION
Remimazolam appears to be safer than propofol for gastroenteroscopy in older adults. However, further studies are required to confirm these findings.
Reconstruction of cervical necrotizing fasciitis defect with the modified keystone flap technique: Two case reports
Authors: Cho Wonseok , Jang Eun A , Kim Kyu Nam 
Published: February 2024

BACKGROUND
Cervical necrotizing fasciitis (CNF) is a rare, aggressive form of deep neck space infection with significant morbidity and mortality rates. Serial surgical debridement acts as the cornerstone of CNF treatment; however, it often results in defects requiring complex reconstructions.
CASE SUMMARY
We report two cases in which the keystone flap (KF) was used for CNF defect coverage: Case 1, an 85-year-old patient with CNF in the anterior neck, and Case 2, a 54-year-old patient with CNF in the posterior neck. Both patients received empirical intravenous antibiotic therapy and underwent serial debridement, enabling adequate wound preparation and stabilization. The final defect size measured 5.5 cm × 12 cm in Case 1 and 6 cm × 11 cm in Case 2. For defect coverage, we employed an 8 cm × 19 cm type II KF based on perforators from the superior thyroid artery in Case 1 and a 9 cm × 18 cm type II KF based on perforators from the transverse cervical artery in Case 2. Both flaps showed complete survival. No postoperative complications occurred in both cases, and favorable outcomes were observed at 7- and 6-month follow-ups in case 1 and 2, respectively.
CONCLUSION
We effectively treated CNF-associated defects using the KF technique; KF is viable for covering CNF defects in carefully selected cases.
Delayed neurological dysfunction following posterior laminectomy with lateral mass screw fixation: A case report and review of literature
Authors: Yan Rui-Zhong , Chen Chao , Lin Chu-Ran , Wei Yan-Hui , Guo Zhi-Jian , Li Ya-Kun , Zhang Quan , Shen He-Yi , Sun Hao-Lin 
Published: February 2024

BACKGROUND
While most complications of cervical surgery are reversible, some, such as symptomatic postoperative spinal epidural hematoma (SEH), which generally occurs within 24 h, are associated with increased morbidity and mortality. Delayed neurological dysfunction is diagnosed in cases when symptoms present > 3 d postoperatively. Owing to its rarity, the risk factors for delayed neurological dysfunction are unclear. Consequently, this condition can result in irreversible neurological deficits and serious consequences. In this paper, we present a case of postoperative SEH that developed three days after hematoma evacuation.
CASE SUMMARY
A 68-year-old man with an American Spinal Injury Association (ASIA) grade C injury was admitted to our hospital with neck pain and tetraplegia following a fall. The C3-C7 posterior laminectomy and the lateral mass screw fixation surgery were performed on the tenth day. Postoperatively, the patient showed no changes in muscle strength or ASIA grade. The patient experienced neck pain and subcutaneous swelling on the third day postoperatively, his muscle strength decreased, and his ASIA score was grade A. Magnetic resonance imaging showed hypointense signals on T1 weighted image (T1WI) and T2WI located behind the epidural space, with spinal cord compression. Emergency surgical intervention for the hematoma was performed 12 h after onset. Although hypoproteinemia and pleural effusion did not improve in the perioperative period, the patient recovered to ASIA grade C on day 30 after surgery, and was transferred to a functional rehabilitation exercise unit.
CONCLUSION
This case shows that amelioration of low blood albumin and pleural effusion is an important aspect of the perioperative management of cervical surgery. Surgery to relieve the pressure on the spinal cord should be performed as soon as possible to decrease neurological disabilities.
Illness presenteeism among physicians and trainees: Study protocol of a scoping review
Authors: Madrazo Lorenzo , Choo-Foo Jade , Domecq Marie-Cécile , LaDonna Kori A. , Humphrey-Murto Susan 
Published: February 2024

Background
Illness presenteeism (IP) is the phenomenon where individuals continue to work despite illness. While it has been a prevalent and longstanding issue in medicine, the recent onset of the COVID-19 pandemic and the growing movement to improve physician wellness brings renewed interest in this topic. However, there have been no comprehensive reviews on the state of literature of this topic.

Purpose
The main aim of this scoping review is to explore what is known about presenteeism in physicians, residents, and medical students in order to map and summarize the literature, identify research gaps and inform future research. More specifically: How has illness presenteeism been defined, problematized or perceived? What methods and approaches have been used to study the phenomenon? Has the literature changed since the pandemic?

Method
Using the Arksey and O’Malley framework several databases will be searched by an experienced librarian. Through an iterative process, inclusion and exclusion criteria will be developed and a data extraction form refined. Data will be analyzed using quantitative and qualitative content analyses.

Potential implications of results
By summarizing the literature on IP, this study will provide a better understanding of the IP phenomena to inform future research and potentially have implications for physician wellness and public health.
Reducción significativa de la satisfacción de las madres respecto a la atención del embarazo y la preparación para la lactancia durante la pandemia COVID
Authors: Segura Barrachina Sara , Ferrándiz Mares Claudia , Pérez López Alba Isabel , López-Cano Ausejo Rebeca , García Tamarit Pilar , Jareño Roglán Enrique Jesús , Bosch Marco María Teresa 
Published: February 2024

Introducción: Debido a la pandemia por el SARS-CoV-2 se produjeron importantes restricciones para la atención presencial y de aforo en los centros sanitarios, lo cual ha desembocado en la merma en algunos aspectos de la calidad de la atención sanitaria y de la satisfacción de los usuarios. El objetivo de este trabajo es valorar el grado de satisfacción de las madres respecto a la asistencia del seguimiento de su embarazo durante la pandemia.
Pacientes y métodos: 1 321 madres que dieron a luz entre marzo de 2019 y mayo de 2021. Estudio descriptivo retrospectivo, basado en encuestas en forma de formularios online.
Resultados: El 42 % de las madres consideran satisfactoria la atención a su embarazo frente al 58 % que la considera insatisfactoria. Si comparamos con los embarazos atendidos antes del inicio del primer confinamiento, el grado de satisfacción se reduce de forma significativa a partir del 14 de marzo del 2020, de un 75 % a un 41 % (p < 0,001). Las causas de insatisfacción que verbalizan con más frecuencia han sido la escasa preparación para el parto y la lactancia, la reducción de las visitas presenciales a los centros y la frecuente ausencia forzada de acompañante en las consultas y exploraciones.
Conclusiones: Las restricciones impuestas por la pandemia han afectado de forma significativa a la satisfacción de las mujeres embarazadas respecto al seguimiento de su embarazo y la preparación para el parto y la lactancia.
A Presença das Literaturas Africanas de Língua Portuguesa no Poliedro – Sistema de Ensino
Authors: Gonçalo de Araújo Elana , Maria Marta dos Santos Silva Nóbrega 
Published: February 2024

As literaturas africanas de língua portuguesa, comparadas com as de outros países, são consideradas recentes. Situadas, panoramicamente, em uma divisão colonial e pós-colonial, essas literaturas ainda são pouco exploradas nas escolas brasileiras, ainda que seu ensino tenha se tornado obrigatório em conformidade com o que preceitua a Lei 10.639/03. Um dos ganhos da leitura e do estudo dessas literaturas constitui-se em possibilidades de trocas interculturais, decoloniais e antirracistas que apresentam implicações psicológicas, sociais, culturais e políticas bastante significativas para o meio educacional do ensino básico. E neste sentido que o presente artigo descreve e analisa o modo como as literaturas africanas de língua portuguesa são abordadas no material produzido pelo Poliedro – Sistema de Ensino, tendo como referência as orientações contidas na Base Nacional Comum Curricular.
Modeling the repetitions‐in‐reserve‐velocity relationship: a valid method for resistance training monitoring and prescription, and fatigue management
Authors: Jukic Ivan , Prnjak Katarina , Helms Eric R. , McGuigan Michael R. 
Published: February 2024

AbstractEstablishing a relationship between repetitions left in reserve and the mean absolute velocity (RIR‐velocity relationship) during resistance training (RT) could allow for objective monitoring, prescription, and real‐time adjustment of the training load and set‐volume. Therefore, we examined the goodness of fit and prediction accuracy of general and individual RIR‐velocity relationships in the free‐weight back squat exercise. The effects of sex, training status and history, as well as personality traits, on the goodness of fit and the accuracy of these relationships were also investigated. Forty‐six resistance‐trained people (15 females and 31 males) performed a one‐repetition maximum (1RM) test, and two repetitions to failure (RTF) tests 72 h apart. We found greater goodness of fit of individual RIR‐velocity relationships compared to general RIR‐velocity relationships. Individual, but not general RIR‐velocity relationships established in the first testing session yielded acceptable prediction accuracy of RIR (mean error <2 repetitions) in the subsequent testing session, regardless of the load used. Similar results were obtained when both general and individual RIR‐velocity relationships were averaged across the loads, suggesting that a single RIR‐velocity relationship covering a range of loads can be used instead of traditional RT methods, potentially allowing for better fatigue management and more efficient adaptation.
Agentenbasiertes Redesign und Neuinterpretation von OPC UA Designstrategien zur Flexiblen Fähigkeitsbasierten Produktion
Authors: Lober Andreas , Lehmann Joel , Weber Jakob , Reichwald Julian , Ollinger Lisa , Völker Sven , Baumgärtel Hartwig 
Published: February 2024

Zusammenfassung
Um zukünftige Produktionssysteme und -prozesse auf Flexibilität, Interoperabilität und Anpassungsfähigkeit auszurichten, sind Konzepte zur Realisierung durchgängiger, horizontaler und vertikaler Integration von Assets (physischen Betriebsmittel) notwendig. In der vorliegenden Arbeit werden ein konventioneller und ein fähigkeitsbasierter Ansatz zur Kommunikation und Steuerung in Produktionsumgebungen mittels Open Platform Communications Unified Architecture (OPC UA) untersucht. Der Schwerpunkt liegt auf der intelligenten Orchestrierung von fähigkeitsbasierten Steuerungslogiken, die in Kombination mit Agentensystemen eine erhöhte Flexibilität und Anpassungsfähigkeit bieten. Dieser Ansatz ermöglicht es, auf Produktionsfähigkeiten rekonfigurierbar zuzugreifen und sie zu effizienten Produktionsservices zu aggregieren. Die Arbeit beleuchtet die Potenziale und Herausforderungen beider Ansätze und zeigt, wie fähigkeitsbasierte Systeme zur Evolution von Produktionssystemen im Sinne der Industrie 4.0 beitragen können. Durch die Verwendung von OPC UA und die Integration von Multi-Agenten-Systemen mit Digitalen Zwillingen stellt das eingeführte Konzept des Skill Orchestration Agenten (SkillOA) einen fortgeschrittenen Ansatz dar, der nicht nur die Effizienz und Leistungsfähigkeit von Produktionsprozessen steigert, sondern auch eine adaptive und dynamische Rekonfiguration von Produktionssystemen ermöglicht, ohne den Quellcode von Maschinensteuerungen anpassen zu müssen. Die Diskussion umfasst die Bewertung der Leistung und Effizienz von fähigkeitsbasierten Architekturen, die Wirksamkeit des Einsatzes von OPC UA zur Unterstützung dieser Architekturen und die notwendigen Anpassungen im Konzept eines Ressourcenagenten für eine effektive Selbst-Rekonfiguration.
Does Uncertainty Matter for the Fiscal Consolidation and Investment Nexus?
Authors: Bournakis Ioannis , Ramírez-Rondán Nelson R. 
Published: February 2024

Abstract
The aim of this research paper is to investigate whether there are non-linearities in the relationship between fiscal consolidation and investment. To achieve this, we take into account the overall state of the economy, as represented by the level of uncertainty. We analyzed a sample of 27 OECD countries from 1996 to 2019 and identified two different regimes of low and high uncertainty. We found that the relationship between fiscal policy and investment is significantly different in these two regimes. In the low uncertainty regime, fiscal tightening has no significant effect on investment. In contrast, in the high uncertainty regime, fiscal tightening has a negative impact on investment, which is three times larger than in the low uncertainty regime. Our results are robust, and have been confirmed through a range of sensitivity tests.
Behavior of solutions of a discrete population model with mutualistic interaction
Authors: Babu Sibi C. , Dilip D. S. , Mathew Smitha Mary 
Published: February 2024

Abstract
We focus on the stability analysis of two types of discrete dynamic models: a discrete dynamic equation and a discrete dynamics system consisting of two equations with mutualistic interaction given by

x

n
+
1

=
a
+

b

x

n

λ

−

(

x

n
−
1

+

x

n
−
k

)

c
+

x

n
−
1

+

x

n
−
k

{x}_{n+1}=a+\frac{b{x}_{n}{\lambda }^{-\left({x}_{n-1}+{x}_{n-k})}}{c+{x}_{n-1}+{x}_{n-k}}

and

x

n
+
1

=

a

1

+

b

1

y

n

λ

−

(

y

n
−
1

+

x

n
−
k

)

c

1

+

y

n
−
1

+

x

n
−
k

,

y

n
+
1

=

a

2

+

b

2

x

n

λ

−

(

x

n
−
1

+

y

n
−
k

)

c

2

+

x

n
−
1

+

y

n
−
k

,

{x}_{n+1}={a}_{1}+\frac{{b}_{1}{y}_{n}{\lambda }^{-({y}_{n-1}+{x}_{n-k})}}{{c}_{1}+{y}_{n-1}+{x}_{n-k}},\hspace{1.0em}{y}_{n+1}={a}_{2}+\frac{{b}_{2}{x}_{n}{\lambda }^{-\left({x}_{n-1}+{y}_{n-k})}}{{c}_{2}+{x}_{n-1}+{y}_{n-k}},

respectively, where

k
∈

{

2
,
3
,

…

}

k\in \left\{2,3,\ldots \right\}

, the constants

a
,

a

1

,
≥
0

a,{a}_{1},\ge 0

,

b
,

b

1

>
0

b,{b}_{1}\gt 0

, and

c
,

c

1

≥
0

c,{c}_{1}\ge 0

be the initial densities, finite rate of increase and the limiting constant associated with the density of the species, respectively, and

a

2

≥
0

{a}_{2}\ge 0

,

b

2

>
0

{b}_{2}\gt 0

, and

c

2

≥
0

{c}_{2}\ge 0

be the initial densities, finite rate of increase, and the limiting constant associated with the density of the mutually interacting species, respectively.

k

k

, a positive integer represents a time delay in the system and

λ
≥
1

\lambda \ge 1

shows a decay factor based on the sum of two past time step population densities. Our main objective is to understand the impact of mutualistic interactions on the stability of discrete dynamic systems. To illustrate the boundedness and stability of these models, we also provide animated plots and bifurcation diagrams.
Diagnostic and prognostic implications of bacteremia in patients with complicated pleural infection
Authors: Kim Chang Ho , Park Ji Eun , Cha Jung Guen , Lim Jae Kwang , Park Jongmin , Lee Yong Hoon , Choi Sun Ha , Seo Hyewon , Yoo Seung Soo , Lee Shin Yup , Cha Seung Ick , Park Jae Yong , Lee Jaehee 
Published: February 2024

Abstract

Objectives
The clinical significance of bacteremia in patients with complicated pleural infection is still uncertain. We aimed to examine the incidence and clinical significance of bacteremia in patients with complicated pleural infection.

Methods
This retrospective study comprised of consecutive patients who received pleural drainage due to complicated parapneumonic effusion or empyema. The clinical, laboratory, and radiologic data and clinical outcome were compared between patients with and without bacteremia. Additionally, the factors associated with overall mortality were evaluated in these patients.

Results
Of 341 patients included in the analysis, 25 (7 %) had a positive blood culture. Blood culture testing added 2 % identification of causative pathogen compared to pleural fluid culture alone. By multivariable analysis, radiologic features of cavitary lesion, a RAPID score≥5, and a positive microbial culture in pleural fluid were independently associated with bacteremia. Despite these clinical distinctions, there was ultimately no significant difference in in-hospital mortality between patients with and without bacteremia (3 vs. 4 %, p=1.0). The only factor significantly associated with overall mortality among patients with complicated pleural infections was a higher RAPID score [HR=1.96 (95 % CI=1.35–2.84)].

Conclusions
The rate of bacteremia in patients with complicated pleural infection was 7 %. Blood culture testing demonstrated limited diagnostic yield and had minimal impact on clinical outcomes compared to pleural fluid culture. Therefore, it seems that blood culture testing is more advantageous for specific patients with suspected pleural infection who have cavitary lesions or a RAPID score≥5.
Exploring the crystal and molecular structures of methenolone and drostanolone enanthate
Authors: Turza Alexandru , Miclăuș Maria O. , Borodi Gheorghe 
Published: February 2024

Abstract
Methenolone and drostanolone are two popular synthetic anabolic-androgenic agents and dihydrotestosterone derivatives which belong to the steroid family. Two esterified prodrugs of methenolone and drostanolone, in the form of methenolone and drostanolone enanthate, have been described from a structural point of view. The crystal structure of drostanolone enanthate was determined by single crystal X-ray diffraction, while the crystal structure of methenolone enanthate was solved by the powder X-ray diffraction technique. The nature and magnitudes of intermolecular interactions were analysed quantitatively by means of crystal lattice energies and Hirshfeld surfaces.
Isolation, structural elucidation, and biological activity of a novel isocoumarin from the dark septate endophytic fungus Phialocephala fortinii
Authors: Bando Kei , Kushibe Ryoga , Kitaoka Naoki , Tamai Yutaka , Narisawa Kazuhiko , Matsuura Hideyuki 
Published: February 2024

Abstract
A novel isocoumarin was isolated from the mycelia of the dark septate endophytic fungus Phialocephala fortinii. The chemical structure was determined to be 8-hydroxy-6-methoxy-3,7-dimethyl-1H-2-benzopyran-1-one based on mass spectrometry, 1H-nuclear magnetic resonance (NMR), and 13C-NMR spectroscopic analyses, including 2D-NMR experiments. The isolated compound inhibited root growth of Arabidopsis thaliana, suggesting its potential as a plant growth regulator.
PROGRAMAS RELACIONADOS CON NEGOCIOS INTERNACIONALES Y EN EL EXTERIOR
Authors: Rincón-Báez William Umar , Becerra Plaza Gisèle Eugenia , Arias-Velandia Nicolas 
Published: February 2024

Para el duodécimo boletín del Observatorio de Ciencias Administrativas de ASCOLFA, se presentan los datos de los programas relacionados con negocios internacionales y exterior del área de conocimiento (AC) de Economía, Administración, Contaduría y afines. Se estudian sus características y sus resultados en las pruebas de estado, en las bases de datos del Sistema Nacional de Información de la Educación Superior (SNIES) y en las competencias genéricas en FTP-ICFES1.