bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of colon carcinoma with 111‐indium‐labeled anti‐CEA monoclonal antibodies (INDACEA) prior to surgery
Authors: Beatty J. David , Philben Vicki J. , Beatty Barbara G. , Williams Lawrence E. , Paxton Raymond J. , Shively Jack E. , Duda Rosemary B. , Vlahos William G. , Werner John L. , Sheibani Khalil , Kemeny M. Margaret , Kokal William A. , Riihimaki Daniel U. , Terz Jose J. 
Published: February 2007

AbstractPatients with primary and/or metastatic colorectal cancer who had been scheduled for operative intervention were injected intravenously with 200 μg of a high‐affinity anti‐carcinoembryonic antigen (CEA) monoclonal antibody labeled with 2 mCi of 111‐indium (Indacea). Patients were imaged by gamma camera at 24 and 48 hours. Primary tumors were identified in 3/10 cases and were not visualized in 3/10 cases. Four scans were considered equivocal. Hepatic metastases were identified as image defects in 5/13 cases and were not visualized in 8/13 cases. All tumors contained CEA by immunoperoxidase staining. In all cases, the primary tumor uptake (5.44 ± 1.07% ID/kg) was much higher than the uptake of the adjacent fat (0.18 ± 0.04% ID/kg). There was a direct correlation between tumor CEA content, tumor radioactivity, and the imaging of primary tumor by Indacea. High liver uptake (30.3 ± 3.0% ID/kg), seen when scanning all patients, was the main limitation of imaging and led to photopenic visualization of hepatic metastases. These results suggest that selection of patients with colorectal carcinoma on the basis of tumor CEA content will lead to improved rates of tumor imaging by Indacea in post‐surgical scanning.
Verrucous pseudonevoid melanoma
Authors: Suster Saul , Ronnen Meyer , Bubis Jose J. 
Published: February 2007

AbstractA case of an unusual variant of malignant melanoma resembling a papillomatous dermal nevus is presented here. The lesion was initially diagnosed as a Spitz nevus, and recurred locally five months after excision. The features which distinguish this lesion from the more common types of benign dermal nevi include the architectural atypia of the melanocytes, with a tendency for continuous proliferation of single cells along the dermoepidermal junction, as well as the presence of cytologic atypia with large hyperchromatic nuclei and mitoses. Despite its seemingly innocent appearance, distinction of this low‐grade variant of melanoma from its benign counterparts is of importance in order to avert the possibility of recurrence and potential metastases.
History, preliminary results, complications, and future prospects of intraoperative radiotherapy
Authors: Hoekstra H. J. , Sindelar W. F. , Kinsella T. J. , Oldhoff J. 
Published: February 2007

AbstractIntraoperative electron beam radiotherapy (IORT) is a new combined modality therapy in the treatment of cancer. IORT is delivered during a surgical procedure to a tumor or tumor bed and areas of possible local regional spread, with the ability to shield or physically move normal tissues and organs out of the treatment volume. IORT is feasible for various intraabdominal, retroperitoneal, pelvic, and other malignancies. It is possible to increase the total radiation dose, thereby improving the therapeutic ratio; a better local control without an increasing morbidity. Although the optimum use of IORT is still unknown, it is believed that its greatest value is in combination with maximal surgical resection of the tumor with or without external beam radiotherapy (EBRT). IORT is still an experimental treatment modality combining surgery, EBRT, and if necessary, chemotherapy. Because IORT is an expensive treatment method, it is important to determine which method is the best and most convenient for the patient. The answer can be given only when prospective, randomized clinical IORT trials and cost‐effectiveness studies are initiated.
Graft versus host disease following transfusion of normal blood products to patients with malignancies
Authors: Kessinger Anne , Armitage James O. , Klassen Lynell W. , Landmark James D. , Hayes James M. , Larsen Arden E. , Purtilo David T. 
Published: February 2007

AbstractA patient undergoing treatment with cytotoxic chemotherapy for Hodgkin's disease developed graft versus host disease (GVHD) following a transfusion of packed red cells. This is the 28th reported patient with a malignancy who did not have a bone marrow transplant and developed GVHD after transfusion of normal blood or blood products. All patients had received cytotoxic chemotherapy prior to acquiring GVHD. The underlying malignancies included lymphoma, acute leukemia, neuroblastoma, rhabdomyosarcoma, and glioblastoma. Twenty‐three of the 28 patients died of GVHD. The incidence of transfusion‐related GVHD in this patient population is low but the illness is often fatal as treatment is largely ineffective. Transfusion‐related GVHD can be prevented by irradiating all blood products with 1500 rad prior to administration.
Chylous ascites following retroperitoneal lymph node dissection successfully treated with peritoneovenous shunt
Authors: Savlov Edwin D. 
Published: February 2007

AbstractA massive lymphatic leak developed following radical retroperitoneal lymph node dissection for recurrent extragonadal seminoma. Chylous ascites persisted for over 3 months, with an average daily external drainage of 1.5 liters, and was successfully treated with a peritoneovenous shunt.
Pathological characteristics of gastric cancer that develop hematogenous recurrence, with special reference to the site of recurrence
Authors: Koga Shigemasa , Takebayashi Masataka , Kaibara Nobuaki , Nishidoi Hideaki , Kimura Osamu , Kawasumi Hiroki , Makino Masato 
Published: February 2007

AbstractThe pathologic characteristics of gastric cancer in 57 patients with hematogenous recurrence were pathologically analyzed by the site of recurrence. In recurrence of gastric cancer that developed in the liver, macroscopic observation revealed that cancers of Borrmann type 2 and 3 were most frequent. Microscopic examination revealed that the rate of occurrence of the medullary type of differentiated or poorly differentiated adenocarcinoma were high and that there were relatively frequent invasion by cancerous cells of the blood vessel that were closely related to the hematogenous metastasis. On the other hand, with respect to recurrence of gastric cancer that had developed in the lung or bone, Borrmann type 3 and 4, respectively, were more frequently observed. In these cases, microscopic analysis revealed that these cancers were poorly differentiated adenocarcinomas. In gastric cancer with bone recurrence, the rate of recurrence of the scirrhous type of tumor were higher than that of other types. It is important, for the management of patients after gastric cancer surgery, to predict possible hematogenous recurrence and its site by evaluation of the pathologic characteristics of the gastric cancer.
Presenting symptoms of neoplastic spinal cord compression
Authors: Copeman Michael C. 
Published: February 2007

AbstractThe cases of 28 patients with neoplastic spinal cord compression were reviewed. The most common presenting symptoms were: back pain (68%), bilateral leg weakness (61 %), urinary retention (36%), and bilateral leg numbness (32 %). Twelve patients (43 %) had known neoplastic disease prior to diagnosis of spinal cord compression. Only two patients (7%) were diagnosed within one week of the onset of major spinal symptoms. The commonest symptoms associated with delay in diagnosis were again back pain (50%) and bilateral leg weakness (38%). However, when certain symptoms were present, diagnosis was almost always delayed, particularly with unilateral leg weakness or pain (loo%), ataxic gait (go%), and back pain (68%). Symptoms in the neck, chest, and arms were also always associated with delayed diagnosis.
Adenocarcinoid tumor of appendix presenting as unilateral krukenberg tumor
Authors: Miller Rodney T. , Sarikaya Huseyin , Jenison Eric L. 
Published: February 2007

AbstractWe report a case of adenocarcinoid tumor of the appendix that presented initially as a unilateral Krukenberg tumor (a signet ring cell mucinous adenocarcinoma with prominent cellular stroma). The primary tumor in the appendix was discovered 10 months later at the time of a “second look” laparotomy. The ovarian metastasis showed both goblet cell elements and tubular formations with numerous argyrophilic cells, indicating that both components of these tumors may metastasize, a finding at variance with the conclusions of some authors who suggest that only the mucinous component may metastasize. Theories of histogenesis of these tumors are discussed, and 12 previously reported cases presenting as Krukenberg tumors (all bilateral) are reviewed. Because the primary tumor in the appendix may be small and easily missed, appendectomy is recommended in all patients with Krukenberg tumors when another primary site cannot be identified at the time of surgery.
Post‐circumcision carcinoma of the penis: II. Surgical management
Authors: Bissada Nabil K. 
Published: February 2007

AbstractPost‐circumcision penile carcinoma is a unique clinical entity that occurs in circumcision scars on the penile shaft. Excision is the only effective treatment. Surgical excision must be tailored to the wide spectrum of disease extention. While some primary tumors can be controlled by standard penectomy, others may require much more extensive resection while some can be adequately controlled without sacrificing the urethra or the corpora. Those who had a conservative operation for less extensive disease had the best results.
Carcinoma of the nasopharynx in northern israel: Epidemiology and treatment results
Authors: Stein M. , Kuten A. , Arbel M. , Ben‐Schachar M. , Epelbaum R. , Wajsbort R. , Klein B. , Cohen Y. , Robinson E. 
Published: February 2007

AbstractBetween 1968 and 1984, 49 patients with carcinoma of the nasopharynx were treated at the Northern Israel Oncology Center. There were 6 stage I–II patients (12%) and 43 stage III‐IV patients (88%). According to ethnic origin, there were 27 (55%) non‐Ashkenazi Jews, 9 (18%) Ashkenazi Jews, and 13 (27%) Arabs. This distribution is different from the percentages of these ethnic groups in Northern Israel. All patients received combined cobalt 60 and 8–10 MeV electron beam radiotherapy to the primary tumor and the entire neck. Twelve stage III‐IV patients received three courses of chemotherapy using bleomycin, methotrexate, and cisplatin (BMP) prior to definitive radiotherapy. The following 5‐yr actuarial survival figures were achieved: all patients, 42%; stage I‐II, 63%; stage III‐IV, 37%; Arabs, 53%, non‐Ashkenazi Jews, 47%; Ashkenazi Jews, 22%; BMP + radiotherapy, 54%; radiotherapy alone, 42%. It is concluded that there is an ethnic‐related pattern of nasopharyngeal carcinoma in Northern Israel. Prognosis is better in non‐Ashkenazi Jews and Arabs with early‐stage lymphoepithelioma or anaplastic carcinoma, younger than 45 yr old, and receiving more than 5,500 cGy. Chemotherapy by BMP improves initial control rates with questionable benefit to long‐term survival.
Hormone receptors in breast cancer: A conservative determination of receptors' presence in tissue and ipsilateral normal mammary gland
Authors: Badellino F. , Canavese G. , Catturich A. , Battistini G. , Amoretti G. , Bertoglio S. , Boccardo F. , Paganuzzi M. , Tanara G. 
Published: February 2007

AbstractEstrogen (ER) and progesterone (PgR) receptors were evaluated in the tumor tissue (T) and in the mammary gland far from malignancy (D) in 36 breast cancers. Results were correlated with the pathological grading of the tumor and the axillary nodal status. It is suggested that a lower cancer malignancy with negative nodes and lower values of pathological grading (G1‐G2) may be associated with a high level of ER in the mammary parenchyma far from the tumor (D).
Merkel tumor of the lower lip: A case report and updated review of the literature work performed at the university of illinois
Authors: Dolezal Rudolph F. , Cohen Mimis , Taxy J. B. 
Published: February 2007

AbstractAn unusual case of Merkel cell carcinoma of the lower lip with metastasis to the submental nodes is presented. Clinical similarities and the histopathologic and prognostic differences between this tumor and basal or squamous cell carcinomas of the head and neck area are discussed and the current thoughts for treatment are presented. The capricious clinical course and the aggressive nature of the Merkel cell tumor is emphasized. A review of the existing literature is also included in an effort to familiarize the head and neck surgeon with this relatively new but potentially lethal pathological cutaneous entity.
Silicone elastomer catheter for chronic vascular access
Authors: Haid Max , Lipschultz Stephen A. , Caughron Annmarie 
Published: February 2007

AbstractThe Evanston and Glenbrook Hospitals' series of 157 consecutive silicone elastomer central venous catheter insertions is reviewed. The total experience was 12,721 patient days (34.85 patient years). The complication rate of insertion was 1.91%, but no patient required chest tube drainage. Seven catheters clotted and could not be salvaged. Seventeen catheters were removed for suspected bacterial infection. Peripheral blood culture was not predictive of catheter tip contamination, while culture of blood drawn through the catheter and insertion site cultures proved most useful. Five bona fide infections were documented for an infection rate of 3.18%. This corresponds to one infection per 2,544 patient days (6.97 patient years). The mean duration of service of the catheter was 81 days with a median of 36 days. The longest duration was 707 days. The silicone elastomer catheter provides safe, dependable venous access for most patients and may be inserted in an outpatient and therefore cost‐effective setting.
Use of carbon dioxide laser for the treatment of premalignant lesions of the oral mucosa
Authors: Flynn Michael B. , White Michael , Tabah R. J. 
Published: February 2007

AbstractThe carbon dioxide laser was used for the treatment of 20 lesions of the oral mucosa in 14 patients. These lesions ranged histologically from bengin hyperkeratosis to verrucous carcinoma. The patients selected for this treatment were identified at high risk to develop malignant lesions in the oral cavity. Precise vaporization of the affected mucosa were carried out using the Cavitron 40–300‐A CO2 Surgical Laser. Destruction of the surface epithelium and submucosa was achieved by using defocused beam at a setting of 10W. Biopsies were taken at 1 cm intervals at the time of laser treatment. Fourteen of the 20 procedures were carried out under local anesthesia on an outpatient basis. Seven procedures were performed under general anesthesia and 2 patients required 24 h postoperative observation. Local control was achieved in 17 of the 20 treated sites. Two of the three treatment failures occurred in patients in whom the final histology revealed either in situ or invasive squamous carcinoma. Only one patient with dysplasia was not controlled after vaporization of the lesion by the carbon dioxide laser. The laser continues to show encouraging results as an alternative to surgical resection of precancerous mucosal lesions of the oral cavity. Vaporization of the dysplastic lesion(s) with carbon dioxide laser is recommended for patients with an identifiable risk for the development of intraoral malignancy. This is an effective, nonmorbid, inexpensive, quick, and relatively painless method of managing this condition.
Primary liposarcoma of the mediastinum in a child
Authors: Plukker J. T. H. M. , Joosten H. J. M. , Rensing J. B. M. , Van Haelst U. J. G. M. 
Published: February 2007

AbstractA case of primary anterior mediastinal liposarcoma occurring in a child is reported. A 5‐year‐old male child complained of exertional dyspnea and left chestpain. The chest roentgenogram showed a complete opacity of the left pleural space. After thoracotomy, the histological examination revealed mediastinal myxoid‐pleomorphic liposarcoma. Surgical resection was performed and chemotherapy was given; 10 months later a recurrence was noted in the mediastinum. The child died 17 months after establishing the diagnosis.
Papillary‐cystic neoplasm of the pancreas
Authors: Pezzi Christopher M. , Schuerch Conrad , Erlandson Robert A. , Deitrick John 
Published: February 2007

AbstractPapillary‐cystic neoplasm of the pancreas is a rare tumor which has recently been described as a distinct, clinicopathological entity. Forty‐four previously described cases from the literature and an additional 52 cases referred to in a brief abstract are reviewed. An additional case occurring in a 25‐year‐old woman is reported. This tumor occurs primarily in young women (mean age 23.3 years) and presents as a large abdominal mass (mean size 10.3 cm) in 63% of patients. Treatment is surgical resection of the involved portions of the pancreas and results of treatment are excellent following this form of therapy alone. The tumor appears to represent a low‐grade malignancy, possibly of ductal cell origin. Only two patients with recurrences and two patients with metastatic disease have been reported. Surgeons should be aware of this curable pancreatic malignancy as they are most often responsible for the evaluation and treatment of the patient presenting with a large abdominal mass.
Fine needle aspiration cytology of the pancreas
Authors: Oland J. , Rosen A. , Reif R. , Sayfan J. , Kent V. , Orda R. 
Published: February 2007

AbstractFine needle aspiration cytology has been increasingly used in recent years to diagnose pancreatic lesions. During a 6 year period, we performed 33 aspiration cytologies of the pancreas. Twenty‐one were performed during exploratory laparotomy, seven under the guidance of computed tomography and five guided by ultrasonography. In seven cases inflammatory lesions were found, while 26 cases were of malignant tumors. Out of these patients, 10 underwent additional tissue biopsy. The correlation between cytology and histology was 100%. We suggest that fine needle cytology of pancreatic and other intraabdominal lesions can be considered an accurate diagnostic procedure.
Islet cell function in long‐term surviving primates after segmental pancreatic allotransplantation
Authors: Du Toit Don F. , Heydenrych Jacobus , Smit Ben , Merwe Emuel Van Der , Louw Gabriel , Zuurmond Theuns , Els Daniel , Weideman Andre , Toit Lorraine Du , Wolfe‐Coote Sonja , Davids Henry 
Published: February 2007

AbstractIslet cell function was studied in pancreatectomized primates with functioning segmental pancreatic allografts more than 100 days after transplantation. Segmental allograft recipients were immunosuppresed with total lymphoid irradiation (TL1) and cyclosporine (CSA). After 100 days, islet function was assessed, at which stage immunosuppression was terminated. Glucose, insulin, glucagon, and C‐peptide response was assessed during intravenous glucose tolerance test (IVGTT) and during arginine and tolbutamide stimulation. In eight normoglycaemic primates in which immunosuppressive treatment had been stopped and with mean graft survival of 145 days, islet stimulation was associated with moderate glucose intolerance, reduced K‐values, hypoinsulinaemia, and low C‐peptide values. Postmortem findings in all animals intentionally killed revealed severe graft atrophy in the absence of significant rejection. Severe graft atrophy in normoglycaemic primates, together with significantly impaired graft function after segmental pancreatic transplantation compared to normal animals, suggest that transplantation of the whole pancreas may be mandatory if normal or near‐normal function is to be achieved.
Odyssey of a sailor's diagnosis since 1795 AD
Authors: Shetty M. R. 
Published: February 2007

AbstractIn the year 1795, a British East Indiaman bound for China had a sick sailor on board who was diagnosed as having testis cancer by the ship's surgeon, who then treated him with an antiscorbutic diet, because scurvy was rampant among the sailors. He was completely cured of his cancer, as reported in the Edinburgh Medical and Surgical Journal by Livingstone in 1805. However, the sailor actually had scurvy and not testis cancer. This diagnostic error has been perpetuated in the medical literature until rectified by Shetty after 191 years. This is a reconstructed account of the sailor's case history and the ship's journey as it actually took place in 1795 AD.
Establishment and characterization of a malignant glioma cell line, GBM8401/TSGH, NDMC
Authors: Lee Wei‐Hwa , Yeh Ming‐Yang , Tu Yen‐Chang , Han Shou‐Hwa , Wang Yeou‐Chih 
Published: February 2007

AbstractA permanent human brain malignant glioma cell line, GBM8401/TSGH, NDMC, has been successfully established from a 31‐year‐old Chinese female with brain glioblastoma multiforme (GBM) in monolayer culture and has been subcultured for more than 100 passages during 24 months in vitro. The tumor cell doubling time in vitro was approximately 38 hr. The tumorigenicity in athymic nude mice was observed; the tumor volume doubling time was approximately 4 days. Glial fibrillary acidic protein (GFAP) and 10‐nm‐diameter intermediate filaments were identified by immunohistochemical peroxidase‐antiperoxidase (PAP), immunofluorescence assay, and transmission electron microscopic methods. The scanning electron microscope revealed numerous surface microvilli and various‐sized blebs. Karyotypic analysis showed this malignant glioma cell line to be of human origin, near‐diploid with a modal chromosome number of 48, XX.
Sexual function after surgery and combination chemotherapy in men with disseminated nonseminomatous testicular cancer
Authors: Nijman J. M. , Koops H. Schraffordt , Oldhoff J. , Kremer J. , Sleijfer D. T. H. 
Published: February 2007

AbstractBetween 1978 and 1982 the sexual functions of 54 patients with a nonseminomatous testicular tumor stage II or III were assessed before and after treatment with surgery and combination chemotherapy. Two years after completing therapy 54% of the patients experienced sexual functional disorders. Greatly reduced or absent antegrade ejaculation was reported by 26 patients; 18 of them had been treated with more or less extensive retroperitoneal lymph node dissection, whereas 8 had not. This means that the chemotherapy might be responsible for ejaculatory disorders in 30% of the patients. Only two patients reported a change in the quality of erection; seven patients experienced a decidedly diminished libido, and five patients noticed their orgasm had changed in a negative sense. The appearance of the contralateral testis changed in 21 patients, who showed “atrophy” of this testis. The findings of this study indicate that sexual and ejaculatory disorders in particular are quite common in men treated for a disseminated nonseminomatous testicular tumor. Many of these disorders seem to be owing to causes other than surgical intervention.
Hepatocellular carcinoma imaging
Authors: Lee Victor W. , Allard Jeffrey C. , Weiss Kenneth , Liebman Howard A. , Carter Anthony 
Published: February 2007

AbstractRadionuclide scintigraphy can give a specific diagnosis when a hypervascular “cold” defect on colloid scans “fills in” with gallium scanning. The majority of hepatocellular carcinomas will also accumulate hepatobiliary agents especially in delayed images. Magnetic resonance imaging is superior to other modalities in providing anatomic detail, such as location and relation to vessels, needed by the surgeon in operative planning.
Southern analysis of human head and neck cancer cells for homologous sequences using yeast gamma repair genes
Authors: Beckett Michael A. , Weichselbaum Ralph R. 
Published: February 2007

AbstractWe employed southern analysis to examine homology between yeast genes RAD 51, RAD 52, RAD 54, and RAD 55 for possible gamma repair genes in radioresistant or repair proficient human tumor cell lines and normal placental DNA. No homology was observed; however, other strategies including further gene restriction and transfection are underway to identify repair genes in human tumors. Understanding mechanisms of radiation repair might lead to more effective clinical radiation treatment protocols.