bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereoselective Synthesis of Tetrahydrofuran Spiro‐β‐Lactams by Ru‐Catalyzed Metathesis of 7‐Oxabicyclo[2.2.1]heptenes.
Authors: Csaky Aurelio G. , Medel Rocio , Murcia M. Carmen , Plumet Joaquin 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 3,4‐Disubstituted 2,5‐Dihydrofurans Starting from the Baylis—Hillman Adducts via Consecutive Radical Cyclization, Halolactonization, and Decarboxylation Strategy.
Authors: Gowrisankar Saravanan , Lee Ka Young , Kim Jae Nyoung 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Inter‐ and Intramolecular Radical Couplings of Ene‐ynes or Halo‐alkenes Promoted by an InCl3/MeONa/Ph2SiH2 System.
Authors: Hayashi Naoki , Shibata Ikuya , Baba Akio 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Polyfunctionally Substituted Thiophene, Thieno[2,3‐b]pyridine and Thieno[2,3‐d]pyrimidine Derivatives.
Authors: Wardakhan Wagnat W. , Shams Hoda Z. , Moustafa Hosam E. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chemoselective Reaction of Benz(g)indole Based Bisheterocycle Dicarboxylate Towards Hydrazine Hydrate: Synthesis and Antimicrobial Activity of New Triheterocycles‐5‐pyrrolylaminocarbonyl/mercaptooxadiazolyl/4‐allyl‐5‐me rcaptotriazolylmethoxy‐1‐furfuryl‐2‐methylbenz(g)indoles.
Authors: Donawade Dundappa S. , Raghu A. V. , Muddapur U. M. , Gadaginamath Guru S. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Single‐Site Hydroxyapatite‐Bound Zinc Catalyst for Highly Efficient Chemical Fixation of Carbon Dioxide with Epoxides.
Authors: Mori Kohsuke , Mitani Yohei , Hara Takayoshi , Mizugaki Tomoo , Ebitani Kohki , Kaneda Kiyotomi 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction of 3,3,5,5‐Tetramethylthiolane‐2,4‐dithione with Benzyne: Novel Formation of Benzodithiole.
Authors: Okuma Kentaro , Tsubone Taeko , Shigetomi Toshiyuki , Shioji Kosei , Yokomori Yoshinobu 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Synthesis and Antimicrobial Activity of Some New Methyl N‐Arylthiocarbamates, Dimethyl N‐Aryldithiocarbonimidates and 2‐Arylamino‐2‐imidazolines.
Authors: Servi Sueleyman , Genc Murat , Guer Seher , Koca Murat 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Isomeric 3‐Phenyl‐5‐(pyridylmethylene)‐2‐thiohydantoins and Their S‐Methylated Derivatives. Molecular and Crystal Structures of (5Z)‐3‐Phenyl‐5‐(pyridin‐2‐ylmethylene)‐2‐thiohydantoin and (5Z)‐2‐Methylthio‐3‐phenyl‐5‐ (pyridin‐2‐ylmethylene)‐3,5‐dihydro‐4H‐imidazol‐4‐one.
Authors: Majouga A. G. , Beloglazkina E. K. , Vatsadze S. Z. , Frolova N. A. , Zyk N. V. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
“Huisgen Reaction” of Aldonitrones with N‐Benzyl Maleimide Leading to Synthesis of 2,3‐Diaryl‐5‐benzyl‐2H‐3,3a,4,5,6,6a‐hexahydropyrrolo [3,4‐d]isoxazole‐4,6‐diones
Authors: Kaur Jaspreet , Singh Baldev , Singal Kewal Krishan 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Phosphine‐Catalyzed Synthesis of 6‐Substituted 2‐Pyrones: Manifestation of E/Z‐Isomerism in the Zwitterionic Intermediate.
Authors: Zhu Xue‐Feng , Schaffner Arnaud‐Pierre , Li Ronald C. , Kwon Ohyun 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cycloadditions of Aryl‐Substituted 1,2,4‐Triazines with 2‐Cyclopropylidene‐1,3‐dimethylimidazolidine — Zwitterions as Discrete Intermediates.
Authors: Ernd Michael , Heuschmann Manfred , Zipse Hendrik 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Preparation of 2‐Pyridylpyridines Using β‐N,N‐Dialkylated Aminoacroleins or Their Equivalent as Vinadinium Tetrafluoroborate.
Authors: Kuwabara Hirokazu , Umihara Ken , Furugori Yasushi , Itoh Isamu 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 2‐Pyridylpyridines via Aza‐Diels—Alder Reactions Between 3‐Pyridyl‐1,2,4‐triazines and Some Vinyl Alkanoates.
Authors: Shintou Taichi , Ikeuchi Fumiaki , Kuwabara Hirokazu , Umihara Ken , Itoh Isamu 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diels—Alder Reactions of N‐Acyl‐2‐alkyl(aryl)‐5‐vinyl‐2,3‐dihydro‐4‐pyridones.
Authors: Comins Daniel L. , Kuethe Jeffrey T. , Miller Teresa M. , Fevrier Florence C. , Brooks Clinton A. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Titanium(IV) Chloride Catalyzed One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones and Thiones
Authors: Nagawade Rahul R. , Kotharkar Sandeep A. , Shinde Devanand B. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction Between Alkyl or Aryl Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of N,N′‐Dimethylbarbituric Acid: Synthesis of 4H‐Pyrano[2,3‐d]pyrimidines.
Authors: Maghsoodlou Malek Taher , Hazeri Norollah , Navvabian Hossein , Razmjoo Zahra , Marandi Ghasem 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Alkoxycarbonyloxyethyl Ester Prodrugs of FR900098 with Improved in vivo Antimalarial Activity.
Authors: Ortmann Regina , Wiesner Jochen , Reichenberg Armin , Henschker Dajana , Beck Ewald , Jomaa Hassan , Schlitzer Martin 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Stereoselective One‐Pot Procedure to Prepare Bis‐ and Tris‐chalcogenide Alkenes via Addition of Disulfides and Diselenides to Terminal Alkynes.
Authors: Venturini Moro Angelica , Nogueira Cristina W. , Barbosa Nilda B. V. , Menezes Paulo Henrique , Teixeira da Rocha Joao Batista , Zeni Gilson 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Steryl Epoxide, Secobutanolide and Butanolides from the Stem Wood of Machilus zuihoensis.
Authors: Cheng Ming‐Jen , Tsai Ian‐Lih , Lee Shoiw‐Ju , Jayaprakasam Bolleddula , Chen Ih‐Sheng 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Prenylated Anthronoid Antioxidants from the Stem Bark of Harungana madagascariensis
Authors: Kouam Simeon F. , Ngadjui Bonaventure T. , Krohn Karsten , Wafo Pascal , Ajaz Asma , Choudhary M. Iqbal 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Approach for the Removal of Metal Ions from Water: Adsorption onto Aquatic Plants and Microwave Reaction for the Fabrication of Nanometals.
Authors: Chefetz B. , Sominski L. , Pinchas M. , Ginsburg T. , Elmachliy S. , Tel‐Or E. , Gedanken A. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Aerobic, Metal‐Catalyzed Oxidation of Alcohols
Authors: Marko Istvan E. , Giles Paul R. , Tsukazaki Masao , Gautier Arnaud , Dumeunier Raphael , Dodo Kanae , Philippart Freddi , Chelle‐Regnault Isabelle , Mutonkole Jean‐Luc , Brown Stephen M. , et al. et al. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Solid‐State Dye Lasers Based on Dipyrromethene Dyes: Recent Developments
Authors: Alvarez M. , Amat‐Guerri F. , Campo L. , Costela A. , Garcia‐Moreno I. , Garcia O. , Gomez C. , Gutierrez C. , Liras M. , Sastre R. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation and Characterization of Novel Ionic Liquids Based on Schiff Base Cation
Authors: Qing‐Hai Cai , Hong Wang , Chao Jin , Bin Lu , Feng Wu , Yong‐Kui Shan 
Published: October 2005

AbstractTwo novel ionic liquids, N,N′‐disalicylideneethylenediaminium acetate and N,N′‐disalicylideneethylenediaminium trifluoroacetate, were prepared and characterized by IR, 1H NMR, DTA‐TG and elemental analysis. The experimental results indicate that the new ionic liquids possess lower melting point and higher electrical conductivity. It is noteworthy that the ionic liquids reported herein are the first member of the ionic liquid family with the Schiff base functional group in the cation.
Stereotactic radiosurgery (SRS)
Authors: Combs Stephanie E. , Widmer Verena , Thilmann Christoph , Hof Holger , Debus Juergen , Schulz‐Ertner Daniela 
Published: October 2005

AbstractBACKGROUNDThis article describes the results of a study of stereotactic radiosurgery (SRS) in the treatment of patients with recurrent malignant glioma.METHODSThirty‐two patients with recurrent glioblastoma multiforme (GBM) were treated for 36 lesions with SRS from 1993 to 2001. Nineteen patients were male and 13 were female. The median age at primary diagnosis of the tumor was 56 years (range, 33–76 yrs). At the time of initial diagnosis a total neurosurgical resection was performed in 7, a subtotal resection in 21, and a biopsy in 4 patients. Histology evaluations revealed glioblastoma multiforme (WHO Grade IV) in all 32 patients. In all patients radiotherapy was performed as the first‐line therapy, applied as fractionated external beam radiotherapy. The median interval between primary irradiation and reirradiation was 10 months. The median dose applied was 15 Gy (range, 10–20 Gy) prescribed to the 80% isodose line that encompassed the target volume. No concomitant chemotherapy was applied.RESULTSTreatment was well tolerated by all patients. No acute toxicities > CTC Grade II occurred. No severe long‐term toxicities including radionecrosis were observed. The median follow‐up time was 13 months (range, 1–89 mo). All patients died of tumor progression during follow‐up. The median overall survival from primary diagnosis of the tumor was 22 months (range, 9–133 mo). The survival rate at 1 year was 90%, and 49% and 26% at 2 and 3 years, respectively. Median overall survival after SRS was 10 months. At 6 and 12 months after SRS, survival rates were 72% and 28%, respectively. Median progression‐free survival after SRS was 7 months.CONCLUSIONSSRS offers effective treatment as a salvage therapy for a subgroup of patients with smaller lesions of recurrent GBM. Cancer 2005. © 2005 American Cancer Society.
Primary pediatric brain tumors
Authors: Wong Tai‐Tong , Ho Donald M. , Chang Kai‐Ping , Yen Sang‐Hue , Guo Wan‐You , Chang Feng‐Chi , Liang Muh‐Lii , Pan Hung‐Chi , Chung Wen‐Yuh 
Published: October 2005

AbstractBACKGROUNDThe purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan.METHODSThe authors reviewed the database of primary pediatric brain tumors in patients < 18 years of age collected in Taipei Veterans General Hospital (Taipei VGH) from 1975 to May 2004. Age and gender distribution, location, and classification of brain tumors were analyzed. Intracranial tumors with diagnostic imaging were included. Nontumoral lesions, cysts, and vascular malformations were excluded.RESULTSThe mean age of these 986 patients was 7.8 years, and the male to female ratio was 1.4:1. Supratentorial (including pineal–quadrigeminal) located tumors (58.3%) was predominant to infratentorial tumors (41.1%). In these series, 886 patients had either histologic diagnosis (842 patients) or clinical diagnosis (44 patients). The most common 5 categories of tumors were astrocytic tumors (31.1%), germ cell tumors (14.0%), medulloblastomas (13.3%), craniopharyngiomas (8.3%), and ependymal tumors (5.8%). Atypical teratoid/rhabdoid tumors (AT/RTs), a rare but highly malignant tumor, were 2.1%. The high incidence of primary intracranial germ cell tumors correlated with reported series from Japan and Korea. For the remaining 100 patients without diagnostic classifications, the majority were most likely astrocytic tumors in brain stem.CONCLUSIONSThe authors analyzed a large hospital series of primary brain tumors in children. Both histologically verified and unverified tumors were recruited to avoid selective bias. Although it was not a study of a population‐based brain tumor registry, it could still be representative of primary pediatric brain tumors in Taiwan. Cancer 2005. © 2005 American Cancer Society.
Sexual functioning in patients with hepatocellular carcinoma
Authors: Steel Jennifer , Hess Stephanie A. , Tunke Laura , Chopra Kapil , Carr Brian I. 
Published: October 2005

AbstractBACKGROUNDThe objectives of the current study were to assess the rates of sexual dysfunction in patients with hepatocellular carcinoma (HCC) and compare the rates of sexual morbidity with a sample of patients diagnosed with chronic liver disease (CLD) and the general population. It was expected that patients diagnosed with HCC would have a greater prevalence of sexual dysfunction than those diagnosed with CLD and the general population, respectively. Furthermore, those patients who reported a sexual dysfunction would also have a poorer quality of life (QOL).METHODSTwenty‐one men diagnosed with HCC and 23 men diagnosed with CLD completed a battery of questionnaires that included the Sexual History Questionnaire and the Functional Assessment of Cancer Therapy‐Hepatobiliary.RESULTSResults indicated that 41% of patients reported a current sexual problem (29% of HCC patients and 71% of patients with CLD) and 43% met the Diagnostic and Statistical Manual of Mental Disorders–4th edition (DSM‐IV) criteria for at least 1 type of sexual dysfunction (25% of patients with HCC and 75% of patients with LD). Of the total sample, 68% reported being diagnosed with a comorbid medical condition or taking a medication that had potential sexual side effects. After eliminating cases with comorbid medical conditions and/or who were taking medications that contributed to sexual morbidity, the rate of sexual problems were found to be similar to that of the general population. Clinically significant differences were found with regard to the QOL. People who were experiencing sexual problems also reported a poorer QOL.CONCLUSIONSAlthough a large percentage of sexual dysfunction may have been secondary to comorbid medical problems and medications, treatment of the sexual dysfunction is still warranted. Cancer 2005. © 2005 American Cancer Society.
Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation
Authors: Peccatori Jacopo , Barkholt Lisbeth , Demirer Tanner , Sormani Maria Pia , Bruzzi Paolo , Ciceri Fabio , Zambelli Alberto , Da Prada Gian Antonio , Pedrazzoli Paolo , Siena Salvatore , Massenkeil Gero , Martino Rodrigo , Lenhoff Stig , Corradini Paolo , Rosti Giovanni , Ringden Olle , Bregni Marco , Niederwieser Dietger 
Published: October 2005

AbstractBACKGROUNDThe objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy.METHODSThe authors studied 70 patients with advanced RCC who underwent allogeneic transplantation with a fludarabine‐based, reduced‐intensity regimen. Ten parameters were analyzed at the time of transplantation for their power to predict survival. Clinical features were examined first univariately; then, variables that were correlated significantly with survival in the univariate analysis were included in a multivariate Cox regression model.RESULTSFactors that were found to be associated significantly with limited survival were performance status, the number of metastatic sites, the presence of mediastinal metastasis, hemoglobin level, C‐reactive protein (CRP) level, lactate dehydrogenase (LDH) level, and neutrophil counts. All these variables were included in a multivariate Cox regression model, and three were retained in the final model. Patients were classified according to the score estimated by the final Cox model in two groups (above or below the median value): The median survival was 3.5 months for patients who had a poor prognosis patients versus 23 months for patients who had a good prognosis.CONCLUSIONSThe current findings suggested that three easily available parameters (performance status, CRP level, and LDH level) could be used to stratify patients with advanced RCC who are candidates for allografting and to assist clinicians in decision‐making and selection of an appropriate treatment program. Cancer 2005. © 2005 American Cancer Society.
The contour integral method for loaded cracks
Authors: Pereira J. P. , Duarte C. A. 
Published: October 2005

AbstractAn extension of the contour integral method (CIM) for the computation of stress intensity factors for loaded cracks is presented. Numerical solutions of the two‐dimensional linear elasticity equations are computed with the p‐version of the generalized finite element method. Polynomial enrichment functions as well as enrichment with near crack tip asymptotic expansion are used. The robustness of the formulation with respect to the size of the extraction domain and the convergence of the computed stress intensity factors and energy release rate are analysed. Copyright © 2005 John Wiley & Sons, Ltd.
GCF: a general coupling framework
Authors: Ford R. W. , Riley G. D. , Bane M. K. , Armstrong C. W. , Freeman T. L. 
Published: October 2005

AbstractCoupled modelling is increasingly necessary to make progress in understanding the science of complex physical phenomena and a number of bespoke (‘custom’) coupled solutions to specific scientific challenges have emerged in recent years. These coupled models generally consist of some framework code in which individual models are embedded. The framework code promotes the required interoperation of the models to solve the larger problem being addressed. Bespoke solutions limit the ability of scientists to share models and to couple them together flexibly to produce (efficient) implementations to address new problems. This paper presents an approach, GCF, which addresses several of these limitations. Individual model sharing and flexibility in composition and deployment is achieved by imposing some lightweight development rules for single models and capturing information relating to the models themselves, to their composition into coupled models and to their deployment onto computational resources as machine‐readable metadata. These metadata can be processed to support the generation of an implementation of the coupled model required by the developer. For example, lean and efficient framework code for the specific coupled model and deployment described by the developer can be generated. Alternatively, GCF‐compliant models can be automatically adapted for use within other, existing frameworks. This paper presents the design and implementation of a bespoke framework generator to achieve the former, and the flexibility in the composition of GCF‐compliant models is demonstrated. Copyright © 2005 John Wiley & Sons, Ltd.
The CCA component model for high‐performance scientific computing
Authors: Armstrong Rob , Kumfert Gary , McInnes Lois Curfman , Parker Steven , Allan Ben , Sottile Matt , Epperly Thomas , Dahlgren Tamara 
Published: October 2005

AbstractThe Common Component Architecture (CCA) is a component model for high‐performance computing, developed by a grass‐roots effort of computational scientists. Although the CCA is usable with CORBA‐like distributed‐object components, its main purpose is to set forth a component model for high‐performance, parallel computing. Traditional component models are not well suited for performance and massive parallelism. We outline the design pattern for the CCA component model, discuss our strategy for language interoperability, describe the development tools we provide, and walk through an illustrative example using these tools. Performance and scalability, which are distinguishing features of CCA components, affect choices throughout design and implementation. Copyright © 2005 John Wiley & Sons, Ltd.
Coupling climate models with the Earth System Modeling Framework and the Common Component Architecture
Authors: Zhou S. J. 
Published: October 2005

AbstractTypical Earth system models involve coupled model components in high‐performance computing (HPC) environments. In the last few years, several frameworks have been developed for HPC applications. Two of them are component‐based frameworks: the Earth System Modeling Framework (ESMF) defining a component interface for Earth system models and the Common Component Architecture (CCA) defining a generic component model. The purpose of this work is to investigate the relationship between ESMF and CCA to deploy the best features of ESMF and CCA into a ESMF–CCA prototype and examine the prototype through a representative coupled climate model. Copyright © 2005 John Wiley & Sons, Ltd.
MpCCI—a tool for the simulation of coupled applications
Authors: Joppich W. , Kürschner M. 
Published: October 2005

AbstractMany industrial and scientific applications are characterized by the interaction of different disciplines, such as fluid–structure interactions. For the individual disciplines sophisticated and validated solvers exist. This paper describes basic ideas, implementation details and application of MpCCI (mesh‐based parallel code coupling interface), a tool for the coupling of different simulation codes. Copyright © 2005 John Wiley & Sons, Ltd.
A Problem Solving Environment for interactive modelling of multiway data
Authors: van Stokkum Ivo H. M. , Bal Henri E. 
Published: October 2005

AbstractA prototype Problem Solving Environment (PSE) is presented for problems in interactive modelling of multiway data. Multiway data result from measurements as a function of two or more independent variables. The PSE comprises a parameter estimation loop and a model adjustment loop. The model can be specified hierarchically using mathematically described building blocks which encapsulate the model assumptions. A typical case study of three‐way data illustrates the need for interactive model adjustment. Requirements for interactive problem solving are discussed. Copyright © 2005 John Wiley & Sons, Ltd.
Integration of two ocean models within Cactus
Authors: Dijkstra Fokke , van der Steen Aad J. 
Published: October 2005

AbstractWe describe our experiences with the integration of two ocean models (THCM and MOM4) within a computational framework, in this case Cactus. The use of a framework like Cactus offers many advantages to computational scientists. When integrating existing code some problems are still encountered. The main problems are structural ones caused by mismatches between data structures and parallelization models. We discuss these problems and try to offer directions for improvement of the available frameworks. Copyright © 2005 John Wiley & Sons, Ltd.
Impact of Structure and Morphology on Charge Transport in Semiconducting Oligomeric Thin‐Film Devices
Authors: Melzer Christian , Brinkmann Martin , Krasnikov Victor V. , Hadziioannou Georges 
Published: October 2005

AbstractWe investigated various thin‐film morphologies of vacuum‐deposited highly luminescent 2,5‐di‐n‐octyloxy‐1,4‐bis[4′‐(styryl)styryl]benzene (Ooct‐OPV5) in a typical light‐emitting‐diode device structure. Important modifications in the thin‐film morphology and structure were obtained by changing the substrate temperature in the range 23–90 °C. Structural analysis by X‐ray and electron diffraction provided clear evidence for polymorphism in evaporated thin films of Ooct‐OPV5. Concomitantly, the hole mobility in the corresponding devices was determined by transient electroluminescence measurements. We demonstrate that the substrate temperature Tsub is a key parameter that controls the hole mobility of the devices. Increasing Tsub between 23 and 84 °C results in a progressive increase of the zero‐field hole mobility from 10−6 to 10−4 cm2 V−1 s−1. The increase in hole mobility is correlated to the average grain size in the thin films. In addition, we give evidence for the existence of a peculiar growth mode in the bulk crystal structure of Ooct‐OPV5, whereby the (a,b) and (b,c) planes can grow in a homoepitaxial manner.