bluuebunny/crossref_metadata_2025_split huggingface dataset:
With or without you: gut microbiota does not predict aggregation behavior in European earwig females
Authors: Cheutin Marie-Charlotte , Leclerc Benjamin , Meunier Joël 
Published: March 2024

Abstract
The reasons why some individuals are solitary, and others gregarious are the subject of ongoing debate as we seek to understand the emergence of sociality. Recent studies suggest that the expression of aggregation behaviors may be linked to the gut microbiota of the host. Here, we tested this hypothesis in females of the European earwig. This insect is ideal for addressing this question, as adults both naturally vary in the degree to which they live in groups and show interindividual variation in their gut microbial communities. We video-tracked 320 field-sampled females to quantify their natural variation in aggregation and then tested whether the most and least gregarious females had different gut microbiota. We also compared the general activity, boldness, body size, and body condition of these females and examined the association between each of these traits and the gut microbiota. Contrary to our predictions, we found no difference in the gut microbiota between the most and least gregarious females. There was also no difference in activity, boldness, and body condition between these two types of females. Independent of aggregation, gut microbiota was overall associated with female body condition, but not with any of our other measurements. Overall, these results demonstrate that a host’s gut microbiota is not necessarily a major driver or a consequence of aggregation behavior in species with inter-individual variation in group living and call for future studies to investigate the determinants and role of gut microbiota in earwigs.
Extra-prostatic extension grading system: correlation with MRI features and integration of capsular enhancement sign for “enhanced” detection of T3a lesions
Authors: Martini Federica , Pigati Maria , Mattiauda Matilde , Ponzano Marta , Piol Nataniele , Pigozzi Simona , Spina Bruno , Cittadini Giuseppe , Giasotto Veronica , Zawaideh Jeries P 
Published: March 2024

Abstract

Purpose
This study aims to confirm the diagnostic accuracy of extra-prostatic extension (EPE) grading system and to explore the predictive capabilities of the prostate MRI while considering various MRI features such as lesion location, apparent diffusion coefficient (ADC) values and capsular enhancement sign (CES).

Methods
Our monocentric study is based on a retrospective analysis of 99 patients who underwent radical prostatectomy from January 2021 to January 2023. The observers reviewed for each lesion, including location (transitional or peripheral zone, anterior or posterior location), capsular contact length, irregular bulging of the capsule, asymmetry of the neurovascular bundle, obliteration of the recto-prostatic angle, macroscopic EPE, ADC value, and CES.

Results
Among 99 patients, 31 patients had EPE. Lesions with EPE have broadercapsule contact (24 mm vs 12 mm) with contact ≥14 mm being the optimal cut-off for EPE discrimination. Among the morphological MRI criteria used to determine the EPE, the one with major sensitivity was shown to be bulging (sen 81%), while macroscopic extension had highest specificity (100%). Univariate analysis showed as significative risk factors for EPE: capsular contact ≥14 mm (P &lt; .001), International Society of Urological Pathology score ≥3 (P = .005), CES (P &lt; .001), bulging (P = .001), neurovascular bundle asymmetry (P &lt; .001) and EPE score ≥2 (P &lt; .001), and in multivariate analysis CES (P = .001) and EPE score ≥2 (P = .004) were significant. The AUC of the EPE score was 0.76, raised to 0.83 when combining it with CES (P = .11).

Conclusion
CES in the setting of multiparametric MRI can increase diagnostic accuracy for the prediction of extracapsular disease.

Advances in knowledge
This study highlights the potential of contrast media in prostate cancer local staging.
‘It Sounds Bizarre, but I Can Call It a Good Thing Now’: Social Worker’s Lived Experiences of Posttraumatic Growth following Dual Disaster Events
Authors: Youssif-Hay Daniel J , Tudor Raewyn , Maidment Jane 
Published: March 2024

Abstract
This article reports on findings from a research study on social workers who practised in Christchurch, New Zealand, following two disaster events: the Canterbury earthquakes of 2010 and 2011 and the 2019 Christchurch mosque attacks. The concept of posttraumatic growth (PTG), with particular reference to vicarious PTG, double exposure and shared resilience, is also explored in relation to this research. Data were gathered via qualitative interviews with twenty-three registered social workers conducted in 2021 and analysed through a reflexive thematic analysis. The findings reveal Christchurch social workers believed, due to their involvement in disaster response work, that their practice skills were enhanced, and they gained new understandings of trauma, including the positive changes which can occur as a result of exposure to traumatic experiences. The social work participants also considered their interpersonal and professional relationships as essential to the development of their own sense of resilience. This article concludes with a discussion on the implications of these findings and PTG theory for contemporary social work practice.
Serial cardiac magnetic resonance imaging for guidance of therapy management in patients treated with anakinra due to recurrent pericarditis
Authors: Bianco Francesco , Bucciarelli Valentina , Coretti Francesca , Cataldi Serena , Damadei Francesca , Raffaelli Elena , Schicchi Nicolò , Omenetti Alessia , Lattanzi Bianca , Berton Emanuela , Chiara Surace Francesca , Baldinelli Alessandra , Breda Luciana , Cazzato Salvatore , Catassi Carlo , Dello Russo Antonio , Gallina Sabina 
Published: March 2024

Abstract

Aims
To determine the utility of serial cardiac magnetic resonance (CMR) imaging for guidance of therapy management in patients treated with anakinra due to recurrent pericarditis (RP), compared with C-reactive protein (CRP) assay alone.

Methods and results
In 2018–21, we enrolled 18 (14.5 ± 1.8 years old, 72% males) consecutive RP patients treated with anakinra (100 mg/day in patients ≥ 18 years old; 2 mg/kg/day &lt; 18 years old) due to RP corticosteroid-dependent or not responsive to colchicine or non-steroidal anti-inflammatory drugs. After hospitalization, they were 1:1 randomized to CMR [no pericardial oedema and/or late gadolinium enchantment (LGE)] or CRP (&lt;0.6 mg/dL). Tests were repeated every 3 months until negative to halve the anakinra dosage and cessation. The idiopathic aetiology was the most prevalent (n = 8, 44%), followed by post-pericardiotomy (n = 6, 33%). After a median treatment period of 8.7 ± 3.6 months, CRP-guided RP patients experienced more recurrences than CMR-guided ones (6 vs. 1, P = 0.016), with the worst prognosis in terms of recurrences (log-rank, P = 0.025) and significantly increased time of treatment (12.7 ± 2 vs. 16.1 ± 3.4 months, P = 0.019). In a multivariable exploratory Cox regression model, the number of previous recurrences and the idiopathic aetiology were independent predictors of RP during the anakinra treatment. New recurrences were subsequently directed to CMR imaging, and therapy was modified according to the LGE/oedema trend. After 1-year follow-up, no further recurrence was detected.

Conclusion
Among patients with RP and treated with anakinra, serial CMR imaging of the pericardium can be utilized as an imaging biomarker, more informative for therapy duration than the solely CRP assessment.

ClinicalTrials.gov Identifier
NCT06071156
Left atrial dysfunction in bicuspid aortic valve patients with severe aortic stenosis is associated with post-operative atrial fibrillation following aortic valve replacement
Authors: Wedin Johan O , Rodin Sergey , Flachskampf Frank A , Simonson Oscar E , Pallin Johan , Hörsne Malmborg Jonathan , James Stefan K , Ståhle Elisabeth , Grinnemo Karl-Henrik 
Published: March 2024

Abstract

Aims
To investigate (i) the association between pre-operative left atrial (LA) reservoir strain and post-operative atrial fibrillation (AF) and (ii) the incidence of post-operative ischaemic stroke events separately in bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) patients after surgical aortic valve replacement for isolated severe aortic stenosis (AS).

Methods and results
We prospectively enrolled 227 patients (n = 133 BAV and n = 94 TAV) with isolated severe AS scheduled for aortic valve replacement. A comprehensive intra- and inter-observer validated pre-operative echocardiogram with an analysis of LA reservoir strain was performed. Post-operative AF was defined as a sustained (&gt;30 s) episode of AF or atrial flutter. The timing of neurological events was defined in accordance with the Valve Academic Research Consortium-3 criteria for stroke. Post-operative AF occurred in 114 of 227 patients (50.2%), with no difference between BAV and TAV patients (48.1 vs. 53.1%, P = 0.452). Persisting post-operative AF at discharge was more frequent in BAV patients (29.7 vs. 8.0%, P = 0.005). Pre-operative LA reservoir strain was independently associated with post-operative AF (odds ratio = 1.064, 95% confidence interval 1.032–1.095, P &lt; 0.001), with a significant interaction between LA reservoir strain and aortic valve morphology (Pinteraction = 0.002). The cumulative transient ischemic attack (TIA)/stroke incidence during follow-up was significantly higher in BAV patients (19.1 vs. 5.8% at 5 years).

Conclusion
Pre-operative LA function was associated with post-operative AF after aortic valve replacement in BAV AS patients, while post-operative AF in TAV AS patients likely depends on transient post-operative alterations and traditional cardiovascular risk factors. TIA/stroke during follow-up was more common in BAV AS patients.
Disclosure of Origin in European Biotechnology Patent Law: A Social Network Analysis Perspective
Authors: Karimov Elnur 
Published: March 2024

Abstract
Recital 27 of the European Union Directive 98/44/EC on the Legal Protection of Biotechnological Innovations mandates the disclosure of the geographical origin of biological material when the invention is based on or incorporates such material. This requirement seeks to monitor the origin of biological materials, often linked to indigenous and local communities, to ensure prior informed consent and equitable benefit-sharing with resource providers. Several European countries, such as Switzerland and Norway, legally require this disclosure, and the Draft International Instrument of the World Intellectual Property Organization is poised to expand the list of nations with such requirements. However, the definition of ‘origin’ presents challenges for patent applicants, as it may refer to the primary source (e.g. indigenous and local communities, the country of origin) or secondary sources (e.g. ex situ plant collections or commercial suppliers). Moreover, defining the information to be disclosed as the origin is crucial for the credibility of disclosure statements. To address this issue, this article pioneers a social network analysis approach to the issue of biopiracy and disclosure of origin. It introduces the network-centric narratives of 30 prominent cases of biopiracy from South and Southeast Asia, Latin America, and Africa, and unveils the average distance between the nodes previously accused of biopiracy and the nodes that correspond to the origin of the biological material in question. By highlighting the role of intermediaries in distorting information within material distribution networks, the findings contest the feasibility of requiring patent applicants to provide information on both primary and secondary sources.
Melanoma-associated fibroblasts in tumor-promotion flammation and antitumor immunity: novel mechanisms and potential immunotherapeutic strategies
Authors: Zhou Qiujun , Jin Xiaoliang , Zhao Ying , Wang Yueping , Tao Maocan , Cao Yi , Yin Xiaohu 
Published: March 2024

Abstract
Melanoma, renowned for its aggressive behavior and resistance to conventional treatments, stands as a formidable challenge in the oncology landscape. The dynamic and complex interplay between cancer cells and the tumor microenvironment has gained significant attention, revealing Melanoma-Associated Fibroblasts (MAFs) as central players in disease progression. The heterogeneity of MAFs endows them with a dual role in melanoma. This exhaustive review seeks to not only shed light on the multifaceted roles of MAFs in orchestrating tumor-promoting inflammation but also to explore their involvement in antitumor immunity. By unraveling novel mechanisms underlying MAF functions, this review aims to provide a comprehensive understanding of their impact on melanoma development. Additionally, it delves into the potential of leveraging MAFs for innovative immunotherapeutic strategies, offering new avenues for enhancing treatment outcomes in the challenging realm of melanoma therapeutics.
Comparison of Daily Versus Admission and Discharge Surveillance Cultures for Multidrug-Resistant Organism Detection in an Intensive Care Unit
Authors: Sansom Sarah E , Shimasaki Teppei , Dangana Thelma , Lin Michael Y , Schoeny Michael E , Fukuda Christine , Moore Nicholas M , Yelin Rachel D , Bassis Christine M , Rhee Yoona , Cisneros Enrique Cornejo , Bell Pamela , Lolans Karen , Aboushaala Khaled , Young Vincent B , Hayden Mary K 
Published: March 2024

Abstract

Background
Admission and discharge screening of patients for asymptomatic gut colonization with multidrug-resistant organisms (MDROs) is a common approach to active surveillance, but its sensitivity for detecting colonization is uncertain.

Methods
Daily rectal or fecal swab samples and associated clinical data were collected over 12 months from patients in one 25-bed medical intensive care unit (ICU) in Chicago, IL and tested for the following MDROs: vancomycin-resistant enterococci; third-generation cephalosporin-resistant Enterobacterales, including extended-spectrum β-lactamase-producing Enterobacterales; and carbapenem-resistant Enterobacterales. MDRO detection by (1) admission and discharge surveillance cultures or (2) clinical cultures were compared to daily surveillance cultures. Samples underwent 16S rRNA gene sequencing to measure the relative abundance of operational taxonomic units (OTUs) corresponding to each MDRO.

Results
Compared with daily surveillance cultures, admission/discharge cultures detected 91% of prevalent MDRO colonization and 63% of MDRO acquisitions among medical ICU patients. Few (7%) MDRO carriers were identified by clinical cultures alone. Higher relative abundance of MDRO-associated OTUs and specific antibiotic exposures were independently associated with higher probability of MDRO detection by culture.

Conclusions
Admission and discharge surveillance cultures underestimated MDRO acquisitions in an ICU. These limitations should be considered when designing sampling strategies for epidemiologic studies that use culture-based surveillance.
Let them talk and we listen: what are diseases of neglected people?
Authors: Duck Mathias 
Published: March 2024

Abstract
This article is a reflection from a person with lived experience of leprosy, who has been working as a global advocate and champion for the rights of persons affected by neglected tropical diseases for the last decade. Synthesising learning from the collection of pieces included within this special supplement that are written from the perspective of people affected by neglected tropical diseases, I argue that it is time to centre the lived experiences of people affected by neglected tropical diseases. These are diseases of neglected people, and it is now time to let them talk while we listen.
Effects of Self-Legitimation and Delegitimation on Public Attitudes toward International Organizations: A Worldwide Survey Experiment
Authors: Ghassim Farsan 
Published: March 2024

AbstractPublic views on international organizations (IOs) have become a matter of central concern. While actors in world politics increasingly try to legitimize or delegitimize IOs, scholars have begun investigating such phenomena systematically. This paper provides the most comprehensive IO (de)legitimation study to date. Building on cueing theory, and considering input as well as output legitimacy, I examine the isolated and combined effects of delegitimation and self-legitimation on public perceptions of IOs. I concentrate on government criticism and citizen protests as two salient practices of delegitimation. In investigating self-legitimation, I focus on IOs’ public statements and institutional reforms. I study public opinion on the UN, World Bank, and WHO, as IOs of different functional scopes and levels of salience. In 2021, I conducted survey experiments on more than 32,000 citizens in ten countries worldwide (Australia, Canada, Colombia, Egypt, France, Hungary, Indonesia, Kenya, South Korea, and Turkey) – weighted by age, gender, region, and education. My main findings are: Delegitimation by governments and citizen protests has some limited effectiveness, depending on the IO in question. While IO self-legitimization statements and reforms in themselves do not boost public support for IOs, they are generally effective at neutralizing delegitimation attempts by governments and citizen protests.
Cardinal Sins? Conspicuous Consumption, Cardinal Status and Inequality
Authors: Hopkins Ed 
Published: March 2024

Abstract
This paper analyzes the social dilemma arising when a large population of individuals with differing incomes have concerns over relative deprivation in terms of visible or conspicuous consumption. These relative concerns are cardinal—people care about the size of the gap between own and others’ consumption—and include inequity aversion, where negative comparisons are more important than positive, rivalrous preferences, and comparison with mean consumption. The resulting Nash equilibrium is inefficient, with consumption generally exceeding the socially efficient level. In this model, the income distribution has a direct effect on behavior and under rivalrous preferences, an increase in incomes for the rich can raise consumption at all income levels and make almost everyone worse off.
On split-octonionic curves
Authors: Alo Jeta , Akbiyik MÜcahit 
Published: March 2024

Abstract
In this paper, we first define the vector product in Minkowski space $\mathbb{R}_{4}^{7}$, which is identified with the space of spatial split-octonions. Next, we derive the $G_{2}-$ frame formulae for a seven dimensional Minkowski curve by using the spatial split-octonions and the vector product. We show that Frenet–Serret formulas are satisfied for a spatial split octonionic curve. We obtain the congruence of two spatial split octonionic curves and give relationship between the $G_{2}-$ frame and Frenet–Serret frame. Furthermore, we present the Frenet–Serret frame with split octonions in $\mathbb{R}_{4}^{8}$. Finally, we give illustrative examples with Matlab codes.
Advancing health equity in cancer survivorship research: National Institutes of Health 2017–2022 portfolio review
Authors: Doose Michelle , Mollica Michelle A , Acevedo Amanda M , Tesauro Gina , Gallicchio Lisa , Reed Crystal , Guida Jennifer , Maher Molly E , Srinivasan Shobha , Tonorezos Emily 
Published: March 2024

Abstract

Background
Communities and researchers have called for a paradigm shift from describing health disparities to a health equity research agenda that addresses structural drivers. Therefore, we examined whether the cancer survivorship research portfolio has made this shift.

Methods
We identified grants focused on populations experiencing health disparities from the National Institutes of Health (NIH) Cancer Survivorship Research Portfolio (N = 724), Fiscal Years 2017–2022. Grant characteristics were abstracted, drivers of health disparities were mapped onto the levels and domains of influence, and opportunities for future research were identified.

Results
A total of 147 survivorship grants focused on health disparities were identified, of which 73.5% of grants focused on survivors from racial and ethnic minoritized groups, 25.9% living in rural areas, 24.5% socioeconomically disadvantaged, and 2.7% sexual and gender minority groups. Study designs were 51.0% observational; 82.3% of grants measured or intervened on at least 1 individual-level of influence compared to higher levels of influence (32.7% interpersonal, 41.5% institutional and community, and 12.2% societal). Behavioral and health care system domains of influence were commonly represented, especially at the individual level (47.6% and 36.1%, respectively). Less frequently represented was the physical and built environment (12.2%).

Conclusions
NIH-funded cancer survivorship research on health disparities is still focused on individual level of influence. However, the proportion of grants examining structural and social drivers as well as the mechanisms that drive disparities in health care and health outcomes among cancer survivors have increased over time. Gaps in funded research on specific populations, cancer types, and focus areas of survivorship science were identified and warrant priority.
Multiomics Analyses Provide New Insight into Genetic Variation of Reproductive Adaptability in Tibetan Sheep
Authors: Han Buying , Tian Dehong , Li Xue , Liu Sijia , Tian Fei , Liu Dehui , Wang Song , Zhao Kai 
Published: March 2024

Abstract
Domestication and artificial selection during production-oriented breeding have greatly shaped the level of genomic variability in sheep. However, the genetic variation associated with increased reproduction remains elusive. Here, two groups of samples from consecutively monotocous and polytocous sheep were collected for genome-wide association, transcriptomic, proteomic, and metabolomic analyses to explore the genetic variation in fecundity in Tibetan sheep. Genome-wide association study revealed strong associations between BMPR1B (p.Q249R) and litter size, as well as between PAPPA and lambing interval; these findings were validated in 1,130 individuals. Furthermore, we constructed the first single-cell atlas of Tibetan sheep ovary tissues and identified a specific mural granulosa cell subtype with PAPPA-specific expression and differential expression of BMPR1B between the two groups. Bulk RNA-seq indicated that BMPR1B and PAPPA expressions were similar between the two groups of sheep. 3D protein structure prediction and coimmunoprecipitation analysis indicated that mutation and mutually exclusive exons of BMPR1B are the main mechanisms for prolific Tibetan sheep. We propose that PAPPA is a key gene for stimulating ovarian follicular growth and development, and steroidogenesis. Our work reveals the genetic variation in reproductive performance in Tibetan sheep, providing insights and valuable genetic resources for the discovery of genes and regulatory mechanisms that improve reproductive success.