bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of tritium labelled (–)–U50,488, a selective kappa opioid agonist
Authors: Thurkauf Andrew , De Gosta Brian , Rice Kenner C. 
Published: October 2006

AbstractThe preparation of 3H labelled (‐)‐trans‐3,4‐dichloro‐N‐methyl‐N‐[2‐(1‐pyrrolidinyl) cyclohexyl]benzeneacetamide (U50,488) in four steps from N‐methylcyclohexylaziridine is described. The synthesis of the pharmacologically active (‐) isomer of U50,488 was accomplished through the resolution of the intermediate 2‐[1‐(3‐pyrrolinyl)]‐N‐methylcyclohexylamine using (+)‐mandelic acid.
Synthesis of tritium labelled sparsomycin
Authors: Van Den Broek Leon A. G. M. , Willemsen Kitty C. M. W. , Schlachter Irene H. G. , Ottenheijm Harry C. J. , Kaspersen Frans M. 
Published: October 2006

AbstractThe synthesis is described of tritiated sparsomycin (5), a broad‐spectrum antitumor antibiotic, with high specific activity (31.4 Ci/mmol, 1.16 TBq/mmol). The radiolabel was introduced by reduction of the cysteine methyl ester 1 with lithium borotritide. 3H NMR analysis of the final product showed the concomitant formation of the mono‐ and ditritiated compound in a ratio of 2:1.
Radiosynthesis of [11C]nifedipine and [11C]nicardipine
Authors: Wilson Alan A. , Dannals Robert F. , Ravert Hayden T. , Donald Burns H. , Lever Susan Z. , Wagner Henry N. 
Published: October 2006

AbstractThe radiosyntheses of the dihydropyridine (DHP) calcium channel blockers [11C]nifedipine and [11C]nicardipine by alkylation of the appropriate DHP 3‐monocarboxylic acid anion with [11C]iodomethane are described. Isolated radiochemical yields of 30–50% were obtained 25 minutes after the end‐of‐bombardment, with specific activities of 400–1400 mCi/μmol at the end‐of‐synthesis. A variety of positron emitting DHPs with different ester side chains in the 3 and 5 positions on the DHP ring may be prepared by this approach using currently available labelled alkylating agents.
Synthesis of [2‐14C]nimodipine
Authors: Scherling D. 
Published: October 2006

Abstract[2‐14C]Nimodipine (8) was synthesized from isopropyl [3‐14C]acetoacetate (5), which was converted to isopropyl 3‐amino[3‐14C]crotonate (6) by reaction with gaseous ammonia in toluene. The 14C‐labelled drug 8 was prepared by the cyclising Michael addition of the 3‐aminocrotonate 6 onto 2‐methoxyethyl 2‐(3‐nitrobenzylidene)acetoacetate (7) in boiling ethanol.
Synthesis of [pyrrolidine‐14C]‐cotinine from 14C‐nicotine
Authors: Peeters R. , Daenens P. 
Published: October 2006

AbstractThe synthesis and purification of 14C‐cotinine is reported. 14C‐nicotine is converted into 14C‐dibromocotinine. Debromination of the latter results in 14C‐cotinine which is purified by high performance liquid chromatography.The total radioactive yield of the synthesis is 44.8%. Starting from 500 μCi 14C‐nicotine, 224 μCi 14C‐cotinine is obtained with a specific activity of 0,23 mCi/mmol.
Synthesis of 1‐ethyl‐1‐(2‐hydroxyethyl)aziridinium‐1,2‐14C2 chloride (1) ([14C]AF64A)
Authors: Mistry Jehangir S. , Abraham Donald J. , Hanin Israel 
Published: October 2006

Abstract1‐Ethyl‐1‐(2‐hydroxyethyl)aziridinium‐1,2‐14C2 chloride (1) ([(14C]AF64A), the labelled analogue of a selective presynaptic cholinotoxin, was prepared from labelled ethylene oxide. The synthetic intermediate, 1,2‐14C2‐2[ethyl[2‐[(tetrahydro‐2H‐pyran‐2‐yl)oxy]ethyl]amino]ethanol, obtained in good yield by the reaction of 2‐[(tetrahydro‐2H‐pyran‐2‐yl)oxy]diethylamine with [14C] ethylene oxide, was converted to the corresponding ethyl chloride derivative using CH3SO2Cl/n‐BuLi. Subsequent removal of the THP group under mild acidic condition gave the mono‐armed mustard as a stable hydrochloride salt in an overall chemical yield of 46% and radiochemical yield of 27%. Conversion of the mustard compound to the corresponding aziridinium species was followed by 1H NMR.
In‐vitro preparation of 113mIn (Ca)‐phytate colloid for liver scintigraphy
Authors: Al‐Janabi M. A. A. 
Published: October 2006

AbstractA method for preparation' of in vitro radiocolloidal solution of 113mIn (Ca)‐phytate is reported. The radiochemical purity was determined using paper chromatography and it was higher than 95%. Liver uptake in mice was high (87%) with low lung uptake. This radiopharmaceutical has, therefore, medical disgnostic specifications.
Synthesis of tritium‐labelled natural prostaglandins of series 1,2,3
Authors: Shevchenko V. P. , Myagkova G. I. , Yu. Lazurkina T. , Dyomin P. M. , Shram S. I. , Zabolotsky D. A. , Yu. Nagayev I. , Belosludtsev Yu. Yu. , Evstigneeva R. P. , Myasoyedov N. F. 
Published: October 2006

AbstractThe complete chemical synthesis of unsaturated precursors of eicosanoids of series 1,2,3 is described. Selective hydrogenation by gaseous tritium of eicosapolyenoic acid acetylenic analogues was used to introduce the label into dihomo‐α‐linolenic, arachidonic and timnodonic acids, from which [3H]PGE, [3H]PGD and [3H]TXB2 were obtained by biosynthesis. From [3H]PGE multiply labelled PGA, PGB, PGFα, PGI2ME, 6‐keto‐PGF1αME were synthesized by chemical methods.
The effect of catalytic reaction conditions on the incorporation of tritium in unsaturated compounds
Authors: Shevchenko V. P. , Yu. Nagayev I. , Myasoedov N. F. 
Published: October 2006

AbstractWe have obtained multiple‐tritium‐labelled 5‐α‐androstan‐3‐one, dihydropicrotoxin, dimethyl‐propyl‐3‐chloro‐butyl‐ammonium chloride, 2,2‐di(trifluoromethyl)‐3,3‐dicyanobicyclohept[2,2,1]ane, dihydroalprenolol, undecanoic acid, dihydro‐m,m'‐di‐tert.‐butyl‐p‐coumaric acid and dihydrofusicoccin. By varying the conditions for the hydrogenation of terminal double bonds one can considerably increase the molar radioactivity of such compounds through isotopic exchange. We discuss some tentative explanations of the effect of the labelling reaction conditions upon the synthesis of compounds with desired properties.
Synthesis of 1‐(2,6‐difluorobenzoyl)‐3‐(2‐fluoro‐4‐(2‐chloro‐4‐trifluoromethylphenoxy) [ring‐U‐14C] phenyl)urea
Authors: Gillam Martyn G 
Published: October 2006

Abstract1‐(2,6‐Difluorobenzoyl)‐3‐(2‐fluoro‐4‐(2‐chloro‐4‐trifluoromethylphenoxy) [ring‐U‐14C]phenyl)urea, a potent new acylurea insecticide and acaricide known as flufenoxuron, was labelled with carbon‐14 starting from o‐dinitro[ring‐U‐14C]benzene 1. 2‐Fluoronitro[ring‐U‐14C]benzene, 2 obtained by fluorination of 1 with n‐tetrabutylammonium fluoride, was converted in two stages to 4‐amino‐3‐fluoro[ring‐U‐14C]phenol 3, coupled with 3‐chloro‐4‐fluorobenzotrifluoride 4 to give 2‐fluoro‐4‐(2‐chloro‐4‐trifluoromethylphenoxy) [ring‐U‐14C]aniline 5, which when reacted with 2,6‐difluorobenzoylisocyanate 6 gave the required urea 7. [aniline ring‐U‐14C] flufenoxuron, having a specific activity of 851MBq/mmol (23mCi/mmol), was obtained in 24% overall radiochemical yield and a radiochemical purity of >99%.
Synthesis of R‐(+)‐ and S‐(−)‐8‐hydroxy‐2‐(N, N‐dipropylamino)‐[2‐3H] tetralin. HCl (8‐OH‐DPAT) a 5HT1A receptor agonist
Authors: Ackland M. J. , Dring L. G. , Jones J. R. , Gilon N. 
Published: October 2006

AbstractThe title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[3H]hydride and n‐propylamine gave 8‐methoxy‐2‐(n‐propylamino)‐[2‐3H]tetralin which was acylated and reduced to give (±) 8‐methoxy‐2‐(N, N‐dipropylamino)‐[2‐3H]tetralin. Treatment with conc. HCl gave (±)‐8‐hydroxy‐2‐(N, N‐dipropylamino)‐[2‐3H]tetralin. The racemate was then resolved by chiral mobile phase chromatography.
Amphiphilic Poly(D,L‐lactic acid)/Poly(ethylene glycol)/Poly(D,L‐lactic acid) Nanogels for Controlled Release of Hydrophobic Drugs
Authors: Lee Wen‐Chuan , Li Yuan‐Chung , Chu I‐Ming 
Published: October 2006

AbstractSummary: Photocrosslinked nanogels with a hydrophobic core and hydrophilic shell are successfully fabricated with the goal of obtaining a biocompatible and biodegradable drug carrier for hydrophobic anticancer drugs. These nanogels are composed of amphiphilic triblock copolymers, poly(D,L‐lactic acid)/poly(ethylene glycol)/poly(D,L‐lactic acid) (PLA‐PEG‐PLA), with acrylated groups at the end of the PLA segments. The copolymers are synthesized by ring‐opening polymerization and possess a low CMC (49.6 mg · L−1), which easily helps to form micelles by self‐assembly. The acrylated end groups allow the micelles to be photocrosslinked by ultraviolet irradiation, which turn the micelles into nanogels. These nanogels exhibit excellent stability as a suspension in aqueous media at ambient temperature as compared to the micelles. Moreover, the size of the nanogels is easily manipulated in a range of 150 to 250 nm by changing the concentration of crosslinkers, e.g., ethylene glycol dimethacrylate, and ultraviolet light irradiation time. The nanogels achieve a high encapsulation efficiency and offer a steady and long‐term release mechanism for the hydrophobic anticancer drug, CPT. It shows that these nanogels are useful for a hydrophobic anticancer drug‐carrier system.Formation of the PLA‐PEG‐PLA nanogels.magnified imageFormation of the PLA‐PEG‐PLA nanogels.
Synthesis of Fluorinated Chitin Derivatives via Enzymatic Polymerization
Authors: Makino Akira , Ohmae Masashi , Kobayashi Shiro 
Published: October 2006

AbstractSummary: Synthesis of fluorinated chitin derivatives has been achieved using chitinase from Bacillus sp. as a catalyst. 6′‐Fluoro‐ (1a), 6‐fluoro‐ (1b) and 6,6′‐difluoro‐ (1c) chitobiose oxazoline derivatives were newly prepared as TSAS monomers for chitinase. Ring‐opening polyaddition of these monomers proceeded effectively at pH 8.0–9.0 and 30–40 °C, giving rise to alternatingly 6‐fluorinated chitin derivatives (2a and 2b) from 1a and 1b, and fully 6‐fluorinated chitin derivative (2c) from 1c under total control of regioselectivity and stereochemistry. XRD measurements revealed that polysaccharides 2a and 2b had crystalline structures similar to that of α‐chitin.
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Influence of Ethylene Ionomers on the Electrical Properties of Crosslinked Polyethylene
Authors: Ke Qing Quan , Huang Xing Yi , Wei Ping , Wang Gen Lin , Jiang Ping Kai 
Published: October 2006

AbstractSummary: Water treeing is a deterioration mechanism observed in the polymeric insulation of extruded cables, which can affect the service life of the transmission and distribution XLPE power cables. To improve the water‐tree resistance of XLPE, it was blended with sodium‐neutralized EAA‐Na ionomers which were formed by neutralization of EAA with NaOH. A series of XLPE/EAA‐Na ionomer blends were investigated for their electrical properties, such as water treeing, electrical breakdown strength, dielectric constant, and dissipation factor. The results strongly suggest that EAA‐Na ionomers can improve the water‐tree resistance of XLPE, and the XLPE/EAA‐Na blends retain excellent dielectric properties. Characterization of XLPE/EAA‐Na blends by using FTIR indicates that the neutralization reaction is effectively achieved. In addition, it can be found that XLPE/EAA‐Na blends are partially compatible from observing morphology observations made by SEM and, therefore, EAA‐Na ionomers can be well dispersed in the matrix.Water tree length of the XLPE/EAA‐0.5Na blends.magnified imageWater tree length of the XLPE/EAA‐0.5Na blends.
Preparation and Characterization of Hyperbranched Polymer/Silica Hybrid Nanocoatings by Dual‐Curing Process
Authors: Amerio Ezio , Sangermano Marco , Malucelli Giulio , Priola Aldo , Rizza Giancarlo 
Published: October 2006

AbstractSummary: Organic‐inorganic nanocomposite hybrid coatings were prepared through a dual‐cure process involving cationic photopolymerization of a hyperbranched epoxy functionalized resin and subsequent condensation of an alkoxysilane inorganic precursor. All the formulations investigated gave rise to photocured films characterized by high gel content values. An increase in glass transition temperature and an increase in storage modulus above Tg in the rubbery plateau is observed with increasing TEOS content in the photocurable formulation. The important role of GPTS on reducing the inorganic domain size and avoiding macroscopic phase separation was demonstrated by TEM analyses.TEM obtained for one of the cured films in the presence of GPTS.magnified imageTEM obtained for one of the cured films in the presence of GPTS.
Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid‐state 3D radial imaging
Authors: Anumula S. , Magland J. , Wehrli S.L. , Zhang H. , Ong H. , Song H.K. , Wehrli F.W. 
Published: October 2006

AbstractIn osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state 31P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro‐CT (μ‐CT) and 31P solution NMR. 3D images of 277 μm isotropic voxel size were obtained in 1.7 hr with SNR ∼ 9. Mineral content was lower in the HY relative to the NO group (SS‐MRI: 9.48 ± 0.4 vs. 11.15 ± 0.31 phosphorus wet wt %, P < 0.0001; μ‐CT: 1114.6 ± 28.3 vs. 1175.7 ± 23.5 mg mineral/cm3; P = 0.003). T1 was shorter in the HY group (47.2 ± 3.5 vs. 54.1 ± 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole‐dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
Autocalibrating parallel imaging of in vivo trabecular bone microarchitecture at 3 Tesla
Authors: Banerjee S. , Choudhury S. , Han E.T. , Brau A.C.S. , Morze C.V. , Vigneron D.B. , Majumdar S. 
Published: October 2006

AbstractIn this work the generalized autocalibrating partially parallel acquisition (GRAPPA) technique was implemented with modified reconstruction and applied to in vivo high‐resolution (HR) magnetic resonance imaging (MRI) of the trabecular bone microarchitecture at 3 Tesla (T) with a multiple‐acquisition balanced steady‐state free precession (b‐SSFP) sequence. Trabecular bone is made up of a network of microstructures (80–140 μm), and its structural deterioration is associated with the skeletal metabolic disorder osteoporosis. HR‐MRI is a promising noninvasive tool for assessing the trabecular microarchitecture in vivo, but it involves long acquisition times. Using partially parallel imaging (PPI) to accelerate the acquisition may help mitigate this shortcoming and allow more flexibility in protocol design. In this study the effects of GRAPPA‐based reconstruction on image characteristics and the measurement of trabecular bone structural parameters were evaluated. Initial studies showed that image quality and depiction of microstructure were preserved in the GRAPPA‐based reconstruction, indicating the feasibility of PPI in HR‐MRI of trabecular bone. The results also demonstrated the potential of PPI for increasing the signal‐to‐noise ratio (SNR) efficiency of multiple‐acquisition b‐SSFP imaging protocols. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
Sind Herbizide harmlose Biozide?
Authors: Grimme Lothar Horst 
Published: October 2006

AbstractDas Prüfzeichen der Biologischen Bundesanstalt Braunschweig besagt nur, daß das geprüfte und zugelassene Pestizid neben hinreichender Wirkung bei sachgemäßer Anwendung keine schädlichen Auswirkungen für die Gesundheit von Mensch und Tier zeigt. Für den Weisen schwebt darüber die Warnung: von harmlos war keine Rede!
Konstitution, Konfiguration und Konformation organischer Arzneistoffe
Authors: Knabe Joachim 
Published: October 2006

AbstractIn den Monographien des DAB 6 war für die meisten organischen Arzneistoffe lediglich deren Summenformel angegeben, Konstitutionsformeln waren nicht vorhanden. Im DAB 7 und in anderen modernen Arzneibüchern werden dagegen für organische Arzneistoffe definierter Struktur Konstitutionsformeln aufgeführt. Diese Formeln geben Auskunft darüber, welche Atome im Molekül untereinander verbunden sind, welche funktionellen Gruppen vorliegen, wo sie sich befinden, ob Mehrfachbindungen vorhanden sind und wo sie liegen.
Pyrido[4,3‐b]carbazole als neue Cytostatika Entwicklung, Chemie und klinische Anwendung
Authors: Pindur Ulf 
Published: October 2006

AbstractDas Carbazolalkaloid Ellipticin (aus Apocynaceen) ist aufgrund seines völlig ebenen Baus, seiner funktionellen Gruppen und seiner Molekülgröße befähigt zur DNA‐Intercalation.
Bi‐ und tricyclische Ergolinanaloge mit dopaminergen Eigenschaften
Authors: Gmeiner Peter 
Published: October 2006

AbstractZur Förderung des wissenschaftlichen Nachwuchses – speziell zur Anerkennung überdurchschnittlicher Habilitationen – im Bereich der Pharmazie vergibt die Deutsche Pharmazeutische Gesellschaft bis zu einmal jährlich den mit 10 000 DM dotierten Johann‐Wolfgang‐Döbereiner Preis (früher Carl‐Mannisch‐Stipendium). Erst kürzlich wurde der Preis für 1994 erneut ausgeschrieben (s. Pharmazie in unserer Zeit Heft 1/94). Mit der Annahme verpflichtet sich der jeweilige Preisträger, in einem für die wissenschaftliche Öffentlichkeit allgemein verständlichen Übersichtsartikel über seine Forschungsergebnisse zu berichten.Preisträger im vergangenen Jahr war Privatdozent Dr. P. Gmeiner (München), der inzwischen einen Ruf auf eine C‐3‐Professur an der Universität Bonn angenommen hat und der hier über wesentliche Aspekte seiner ausgezeichneten Habilitationsschrift berichtet.
Molekulare Ähnlichkeit. 1. Chemische Struktur und biologische Wirkung
Authors: Kubinyi Hugo 
Published: October 2006

AbstractMolekulare Ähnlichkeit läßt sich nicht absolut definieren. Sie bezieht sich immer auf das umgebende Medium, im Fall von Wirkstoffen auf die Bindestelle des Proteins, mit denen sie in Wechselwirkung treten. Struktur‐Wirkungsbeziehungen verschiedener Substanzgruppen erläutern allgemeine Prinzipien, belegen aber auch die Probleme bei der Vorhersage biologischer Wirkungen.
Swelling and diffusion characteristics of novel semi‐interpenetrating network hydrogels composed of poly[(acrylamide)‐ co‐(sodium acrylate)] and poly[(vinylsulfonic acid), sodium salt]
Authors: Mohan Y Murali , Dickson Joseph P , Geckeler Kurt E 
Published: October 2006

AbstractA series of novel semi‐interpenetrating polymer networks (IPNs) composed of poly[(acrylamide)‐co‐(sodium acrylate)] with varying amounts (5, 10, and 15 wt%) of poly[(vinylsulfonic acid), sodium salt] was synthesized. The semi‐IPN hydrogels were characterized by infrared spectroscopy. The swelling behavior of these IPNs was studied in distilled water/physiological solutions/buffer solutions/salt solutions. As the amount of poly[(vinylsulfonic acid), sodium salt] increased in the network, the swelling capacity of the semi‐IPNs increased considerably. The swelling and diffusion characteristics such as water penetration velocity (v), diffusion exponent (n), and diffusion coefficient (D) were calculated in distilled water, as well as in other physiological solutions. The highest swelling capacity was noted in urea and glucose solutions. The semi‐IPN hydrogels followed non‐Fickian diffusion behavior in water and physiological fluids, whereas Fickian behavior was observed in buffer solutions. The stimuli‐responsive characteristics towards physiological fluids, salt concentration, and temperature of these semi‐IPN hydrogels were also investigated. The swelling behavior of the semi‐IPNs decreased markedly with an increase of the concentration of the salt solutions. Copyright © 2006 Society of Chemical Industry
Terpolymerization kinetics of methyl methacrylate or styrene/dodecyl methacrylate/octadecyl methacrylate systems
Authors: Jukić Ante , Rogošić Marko , Vidović Elvira , Janović Zvonimir 
Published: October 2006

AbstractThis study describes low‐conversion terpolymerization kinetic investigations of methyl methacrylate/dodecyl methacrylate/octadecyl methacrylate (MMA/DDMA/ODMA) and styrene/dodecyl methacrylate/octadecyl methacrylate (ST/DDMA/ODMA) systems. Terpolymerizations were performed isothermally (70–105 °C), in 1 mol dm−3 xylene solutions, using 0.01 mol dm−3 of bifunctional peroxide initiator 1,1‐di(tert‐butylperoxy)‐3,3,5‐trimethylcyclohexane or monofunctional tert‐butylperoxy‐2‐ethylhexanoate. Synthesized terpolymers were characterized with respect to composition and molar mass distribution. Initial polymerization reaction rates as well as terpolymer average molar masses decreased with increasing MMA or ST content in the monomer mixture, for both initiators and all investigated temperatures. Overall reaction rates were found to be significantly larger for the MMA/DDMA/ODMA system. In the MMA/DDMA/ODMA system, experimental terpolymer compositions were found to be similar to the initial monomer feed compositions—all the experimental monomer feed mixtures were close to the azeotropic composition. The Alfrey–Goldfinger terpolymerization equation was successfully used for the description of MMA/DDMA/ODMA terpolymerization kinetics, where the existence of the true azeotropic ternary point was established. The same equation did not perform as well for the ST/DDMA/ODMA terpolymerization system. Copyright © 2006 Society of Chemical Industry
Direct spincasting of polystyrene thin films onto poly(methyl methacrylate)
Authors: Ennis David , Betz Heike , Ade Harald 
Published: October 2006

AbstractThe low vapor pressure solvent 1‐chloropentane was used to directly spincast polystyrene (PS) films onto poly(methyl methacrylate) (PMMA) with smooth surfaces and sharp interfaces. Interface roughness after removal of the PS layer with cyclohexane was determined with scanning force microscopy to be <1 nm. Dynamic secondary mass spectroscopy revealed an interfacial width below the resolution limit of ∼10 nm. Large area bilayers with smooth surfaces could be created. In addition, direct spincasting with 1‐chloropentane allows the production of thin PS films (<15 nm) and films of low molecular weight (<5 kDa) PS, all of which would be impossible to produce for this important model system by the traditional water‐transfer method. 1‐chloropentane was confirmed to be a sufficiently selective solvent for PS by measuring the Flory–Hugginsχparameters of 1‐chloropentane with PS and PMMA, respectively, with inverse gas chromatography. In the search for a suitable selective solvent, the authors have also examined the role of vapor pressure in spin casting smooth films over a wider molecular weight (4.3–190 kDa) and thickness range (∼5–500 nm) than previously reported. Only solvents with low vapor pressure produced high quality PS films. Methylcyclohexene can also be used to produce excellent, directly cast PS/PMMA bilayers, but with a smaller molecular weight and thickness window compared with 1‐chloropentane. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 3234–3244, 2006