bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of the make a match model on Students’ Mapel PAI Learning Achivement and Civil Decision
Authors: Ridho Yusuf , Hidayah Nur , Amin Lailla Hidayatul 
Published: March 2024

This research aims to investigate the effect of using the Make a Match learning model in learning Islamic Religious Education and Character on the learning achievement of class VII students at State Junior High School 2 Tawangmangu.
With a quantitative approach, this research involves a type of field research with an experimental design. Data was collected through direct observation in the field and the use of questionnaires to measure the level of implementation of the Make a Match model and student learning achievement. The research population was all class VII students with a total of 110 students, while the research sample was selected as 33 students using the random sample method. Data analysis was carried out using validity and reliability tests, as well as statistical analysis to determine the effect of using the Make a Match model on student learning achievement.
The research results show that the level of use of the Make a Match model and student learning achievement are in the medium category. However, statistical analysis shows that there is no significant relationship between the use of the Make a Match model and student learning achievement. The correlation between the two variables is declared weak with a coefficient of 0.029 and a significance of 0.873. The conclusions of this research highlight the importance of further exploration of more effective learning methods in the context of religious and character education in junior high schools. This research provides insight into the effectiveness of the Make a Match learning model in the context of religious and character education at SMP Negeri 2 Tawangmangu. The implications of this research highlight the importance of further exploration of more effective and quality learning methods.
Survei kekuatan otot lengan, koordinasi mata-tangan dan kemampuan smash pada peserta ekstrakurikuler bolavoli SMA Negeri 1 Bululawang
Authors: Prayoga Fatih , Tomi Agus , Yudasmara Dona Sandy 
Published: March 2024

Permasalahan penelitian yang peneliti ambil ialah masih terdapat kurang di teknik kemampuan smash bola voli peserta putra ekstrakurikuler SMAN 1 Bululawang. Penelitian dilakukan untuk mendeskripsikan tingkat power otot lengan, koordinasi mata-tangan dan kemampuan smash. Penelitian bertujuan untuk melihat tingkat power otot lengan, koordinasi mata-tangan dan kemampuan smash. Penelitian menggunakan penelitian deskriptif kuantitatif dengan metode survei tes. Sampel penelitian ialah 15 siswa dengan teknik pengambilan purposive sampling. Instrumen menggunakan tes, saat melaksanakan kegiatan tes direkam dan ditambah dokumentasi. Tes yang dilaksanakan meliputi power otot lengan, koordinasi mata dan tangan dan kemampuan smash. Dari hasil penelitian menunjukan power otot lengan peserta secara keseluruhan memiliki persentase sebesar 51% termasuk dalam kategori kurang, selanjutnya pada koordinasi mata-tangan memiliki persentase sebesar 28% termasuk dalam kategori kurang sekali, sedangkan kemampuan smash memiliki persentase sebesar 64% termasuk dalam kategori cukup. Penelitian ini bisa disimpulkan maka kekuatan otot lengan belum signifikan terhadap kemampuan smash, koordinasi mata dan tangan belum signifikan terhadap kemampuan smash dan kekuatan otot lengan dan koordinasi mata-tangan terdapat hubungan yang signifikan terhadap kemampuan smash.
Research trends on the gut microbiota in endocrine metabolism: a thematic and bibliometric analysis
Authors: Doğan Durmus , Çelik Taylan 
Published: March 2024

BackgroundGut microbiota studies in the field of endocrinology metabolism have attracted increasing attention in recent years. To comprehensively assess the evolving landscape of this research field, we conducted a thorough bibliometric analysis of gut microbiota studies in endocrinology metabolism indexed in the Web of Science database.MethodsWe collected and analyzed 3,339 original research articles and reviews published from 1972 to 2023. Using various bibliometric indicators, we investigated publication trends, country contributions, international collaborations, prolific authors, top journals, and influential articles.ResultsOur analysis revealed a significant upsurge in publications after 2010, indicating a growing scientific interest in microbiota and endocrinology metabolism. Keyword and thematic analyses have identified gut microbiota, obesity, diabetes, and inflammation as core research themes. Additionally, the roles of probiotics and prebiotics are increasingly researched for their therapeutic effects in shaping the microbiota.ConclusionThis study reveals that research in endocrinology metabolism is increasingly decoding the connection between gut microbiota and diseases. There’s also a growing focus on microbiota manipulation, which points to a shift towards personalized medicine. Future research should focus on integrating these findings into clinical practice, moving from lab-based studies to real-world patient care.
The impact of dyslipidemia on prognosis of patients after endovascular abdominal aortic aneurysm repair
Authors: Luo Xin , Guo Qiang , Wang Jiarong , Li Yiyuan , Zhao Jichun , Huang Bin , Chen Xiyang 
Published: March 2024

IntroductionDyslipidemia is common in patients with abdominal aortic aneurysm (AAA). However, there is insufficient research on the impact of dyslipidemia on the postoperative outcomes of patients with AAA after endovascular aortic aneurysm repair (EVAR). This study aimed to determine the impact of dyslipidemia on the prognosis of patients with AAA treated with EVAR.MethodWe retrospectively reviewed patients with AAA who underwent EVAR at our hospital between 2010 and 2020. The baseline characteristics and prognoses of patients in the dyslipidemia and non-dyslipidemia groups were analyzed.ResultsA total of 641 patients were included; the prevalence of dyslipidemia in patients with AAA was 42.3% (271/641), and the mean follow-up time was 63.37 ± 26.49 months. The prevalence of diabetes (10.0% vs. 15.1%, P = 0.050), peripheral arterial disease (17.3% vs. 25.8%, P = 0.018), and chronic kidney disease (3.0% vs. 6.3%, P = 0.043) was higher in the dyslipidemia group. The three-year all-cause mortality rate after EVAR was 9.98% (64/641), and there was no difference in the incidence of all-cause mortality (10.27% vs. 9.59%, P = 0.778) between the two groups. A total of 36 (5.62%) major adverse cardiovascular and cerebrovascular events (MACCEs) were observed within 3 years and were more common in patients with dyslipidemia (2.97% vs. 9.59%, P &lt; 0.001). The incidence of stent-related complications in all patients was 19.97% (128/641), and there was no difference in the incidence of stent-related complications between the two groups (22.16% vs. 16.97%, P = 0.105); however, the incidence of type I endoleak in the dyslipidemia group was lower than that in the non-dyslipidemia group (9.19% vs. 4.06%, P = 0.012). Cox-regression analysis showed that high level of high-density lipoprotein cholesterol (HDL-C) was the protective factor (HR, 0.203, 95% CI, 0.067–0.616, P = 0.005) for MACCES, but it was the risk factor for type I endoleak (HR, 2.317, 95% CI, 1.202–4.466, P = 0.012).ConclusionDyslipidemia did not affect the mortality of patients with AAA who underwent EVAR; however, it may increase the incidence of MACCEs. Dyslipidemia may decrease the incidence of type I endoleaks after EVAR; however, further studies are warranted. We should strengthen the postoperative management of patients with dyslipidemia, prevent the occurrence of MACCEs.
Comparison of the RF-CL and CACS-CL models to estimate the pretest probability of obstructive coronary artery disease and predict prognosis in patients with stable chest pain and diabetes mellitus
Authors: Chen Tao , Shao Dujing , Zhao Jia , Xiu Mingwen , Li Yaoshuang , He Miao , Tan Yahang , An Yanchun , Zhang Xiangchen , Zhao Jia , Zhou Jia 
Published: March 2024

BackgroundThe most appropriate tool for estimating the pretest probability (PTP) of obstructive coronary artery disease (CAD) in patients with diabetes mellitus (DM) and stable chest pain (SCP) remains unknown. Therefore, we aimed to validate and compare two recent models, namely, the risk factor-weighted clinical likelihood (RF-CL) model and coronary artery calcium score (CACS)-weighted clinical likelihood (CACS-CL) model, in these patient populations.MethodsA total of 1,245 symptomatic patients with DM, who underwent CACS and coronary computed tomographic angiography (CCTA) scan, were identified and followed up. PTP of obstructive CAD for each patient was estimated using the RF-CL model and CACS-CL model, respectively. Area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to assess the performance of models. The associations of major adverse cardiovascular events (MACE) with risk groups were evaluated using Cox proportional hazards regression.ResultsCompared with the RF-CL model, the CACS-CL model revealed a larger AUC (0.856 vs. 0.782, p = 0.0016), positive IDI (12%, p &lt; 0.0001) and NRI (34%, p &lt; 0.0001), stronger association to MACE (hazard ratio: 0.26 vs. 0.38) and less discrepancy between observed and predicted probabilities, resulting in a more effective risk assessment to optimize downstream clinical management.ConclusionAmong patients with DM and SCP, the incorporation of CACS into the CACS-CL model resulted in a more accurate estimation for PTP and prediction of MACE. Utilizing the CACS-CL model, instead of the RF-CL model, might have greater potential to avoid unnecessary and omissive cardiovascular imaging testing with minimal cost.
Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study
Authors: Wu Chenkai , Xu Yuefei , Xing Zhenhua 
Published: March 2024

BackgroundThe contribution of total fat mass and regional fat distribution to the risk of AF has rarely been studied.MethodsThis prospective cohort study(N=494,063) evaluated the association of total fat mass measured by fat percentage (FP) and regional fat measured by arm fat percentage (AFP), trunk fat percentage (TFP), and leg fat percentage (LFP) with incident AF. A subgroup (N = 25,581) underwent MRI, which allowed us to further assess whether visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) of the trunk fat exert different effects on AF incidence.ResultsOver, a median 12.9 ± 1.86 years of follow-up, 29,658 participants (cumulative rate: 6.0%) developed AF. Each 1-standard deviation (SD) increase in LFP was associated with a 16% lower risk of AF (HR: 0.84, 95% CI: 0.82, 0.85). The association between FP and AF was weaker than that between LFP and AF (HR: 0.90, 95% CI: 0.89, 0.92). AFP and TFP only had a marginal association with a lower incidence of AF. Both the VAT and ASAT showed a U-shaped relationship with incident AF.ConclusionsFat mass, mainly leg fat mass, was associated with a lower risk of AF. ASAT did not exert protective effects.
The interplay of inflammation and placenta in maternal diabetes: insights into Hofbauer cell expression patterns
Authors: Tauber Zdenek , Burianova Adela , Koubova Katerina , Mrstik Max , Jirkovska Marie , Cizkova Katerina 
Published: March 2024

IntroductionInflammation of the placenta is harmful to both the fetus and the mother. Inflammation is strongly associated with diabetes, a common complication of pregnancy. Hofbauer cells (HBCs), unique immune system cells of fetal origin in the placenta, play complex roles, including growth of placental villi and their branching, stromal remodelling, and angiogenesis.MethodsOur study investigated the expression of IL-1β, IL-10, CYP2C8, CYP2C9, CYP2J2 and sEH in HBCs from patients with type 1 diabetes mellitus (T1DM) and gestational diabetes mellitus (GDM) compared to healthy controls using immunohistochemistry. We also assessed the structure of the villus stroma using Masson´s trichrome.ResultsIn T1DM, HBCs showed inflammatory activation characterised by increased IL-1β and decreased CYP epoxygenase expression compared to normal placentas. Conversely, significant inflammation in HBCs appeared less likely in GDM, as levels of IL-1β and CYP epoxygenases remained stable compared to normal placentas. However, GDM showed a significant increase in sEH expression. Both types of diabetes showed delayed placental villous maturation and hypovascularisation, with GDM showing a more pronounced effect.ConclusionThe expression profiles of IL-1β, CYP epoxygenases and sEH significantlly differ between controls and diabetic placentas and between T1DM and GDM. These facts suggest an association of the CYP epoxygenase-EETs-sEH axis with IL-1β expression as well as villous stromal hypovascularisation. Given the stable high expression of IL-10 in both controls and both types of diabetes, it appears that immune tolerance is maintained in HBCs.
Impact of patient-centered communication on patient satisfaction scores in patients with chronic life-limiting illnesses: an experience from Kenya
Authors: Sirera Betty , Naanyu Violet , Kussin Peter , Lagat David 
Published: March 2024

BackgroundPatient satisfaction remains a key area of interest worldwide; utilizing a patient-centered communication approach, particularly with patients with chronic life-limiting illnesses may be one way to achieve this. However, there is a dearth of empirical information on the effect of patient-centered communication strategies in patients with chronic life-limiting illnesses in Kenya on patient satisfaction.ObjectivesThe objective of this study was to assess the impact of patient-centered communication on patient satisfaction.MethodsWe conducted our study at a tertiary teaching and referral hospital in Kenya. We utilized a quasi-experimental pre-test post-test study design and engaged 301 adult medical in-patients with chronic life limiting conditions. We randomized them to receive patient-centered communication, and evaluated the change in patient satisfaction scores using an adapted Medical Interview satisfaction Scale 21 (MISS 21).ResultsTwo hundred and seventy-eight out of 301 recruited participants completed the study. The baseline characteristics of the participants randomized to the control and intervention arms were similar. Although both the control and intervention arms had a decline in the mean difference scores, the intervention arm recorded a larger decline, −15.04 (−20.6, −9.47) compared to −7.87 (−13.63, −2.12), with a statistically significant mean difference between the two groups at −7.16 (−9.67, −4.46). Participants in the intervention arm were less likely to: understand the cause of their illness (p &lt; 0.001), understand aspects of their illness (p &lt; 0.001), understand the management plan (p &lt; 0.001), receive all the relevant information on their health (p &lt; 0.001), and to receive adequate self-care information (p &lt; 0.001). They were also less likely to acknowledge a good interpersonal relationship with the healthcare providers (p &lt; 0.001), to feel comfortable discussing private issues (p &lt; 0.004), and to feel that the consultation time was adequate (p &lt; 0.001).Conclusion and recommendationContrary to expectation, patient-centered communication did not result in improved patient satisfaction scores. Further studies can evaluate factors affecting and explaining this relationship and assess intermediate and long-term effects of provision of a patient-centered communication in diverse global contexts.
Association between early spontaneous abortion and homocysteine metabolism
Authors: Lei Fangliang , Zhang Lili , Wang Li , Wu Wentao , Wang Fei 
Published: March 2024

ObjectiveThe purpose of this study is to explore the effects of homocysteine (HCY) metabolism and related factors on early spontaneous abortion.MethodsWe conducted a hospital-based case–control study and included a total of 500 cases and 1,000 controls in Shaanxi China. Pregnant women waiting for delivery in the hospital were interviewed to report their characteristics and other relevant information during pregnancy. The unconditional Logisitic regression model was applied to assess the association between early spontaneous abortion and HCY metabolism and related factors. The multiplicative model was applied to assess the effects of interaction of HCY metabolism and related factors on early spontaneous abortion. The logit test method of generalized structural equation model (GSEM) was used to construct the pathway diagram of HCY metabolism and related factors affecting early spontaneous abortion.ResultsFolic acid supplementation and adequate folic acid supplementation during periconception were the protective factors of early spontaneous abortion (OR = 0.50, 95% CI: 0.38–0.65; OR = 0.44, 95% CI: 0.35–0.54). The serum folate deficiency, higher plasma HCY in early pregnancy, the women who carried the MTHFR 677TT genotype were the risk factors of early spontaneous abortion (OR = 5.87, 95% CI: 1.53–22.50; OR = 2.94, 95% CI: 1.14–7.57; OR = 2.32, 95% CI: 1.20–4.50). The women’s educational level and maternal and child health care utilization affected the occurrence of early spontaneous abortion by influencing the folic acid supplementation during periconception. The folic acid supplementation during periconception affected the occurrence of early spontaneous abortion by influencing the level of serum folate or plasma HCY in early pregnancy. The maternal MTHFR 677 gene polymorphism affected the occurrence of early spontaneous abortion by influencing the level of serum folate in early pregnancy. In terms of the risks for early spontaneous abortion, there was multiplicative interaction between higher plasma HCY in early pregnancy, serum folate deficiency in early pregnancy and maternal MTHFR 677TT genotype (OR = 1.76, 95% CI: 1.17–4.03), and there was multiplicative interaction between higher plasma HCY and serum folate deficiency in early pregnancy (OR = 3.46, 95% CI: 2.49–4.81), and there was multiplicative interaction between serum folate deficiency in early pregnancy and maternal MTHFR 677TT genotype (OR = 3.50, 95% CI: 2.78–5.18). The above interactions are all synergistic. The occurrence risk of early spontaneous abortion was significantly increased if multiple factors existed at the same time.ConclusionOur study is the first time to construct the pathway of HCY metabolism and related factors affecting early spontaneous abortion, and provides a comprehensively new idea to prevent and reduce the occurrence of spontaneous abortion.
Exploring the association between serum phosphate levels and mortality in patients hospitalized with infectious diseases: a nationwide study
Authors: Frenkel Amit , Shiloh Adi , Vinokur Victoria , Boyko Matthew , Binyamin Yair , Dreiher Jacob 
Published: March 2024

ObjectiveThe purpose of this study was to examine associations of serum phosphate levels with mortality, target organ damage and length of hospital stay in adults with infectious diseases hospitalized outside of the intensive care unit.MethodsThis nationwide retrospective cohort study comprised patients admitted with infections, to medical and surgical departments in eight tertiary hospitals during 2001–2020. The main exposure variable was the first serum phosphate levels at admission (up to 1 week). The analysis included multivariable logistic regression models and quantile regression.ResultsOf 126,088 patients (49% males, mean age: 69.3 years), 24,809 (19.7%) had decreased phosphate levels, 92,730 (73.5%) normal phosphate levels, and 8,549 (6.8%) elevated phosphate levels on admission. Overall- and in-hospital mortality rates were highest among those with hyperphosphatemia (74.5 and 16.4%, respectively), followed by those with normophosphatemia (57.0 and 6.6%), and lastly the hypophosphatemia group (48.7 and 5.6%); p &lt; 0.001 for all. After adjusting for confounders, the lowest predicted mortality rate was observed in the normophosphatemia group. In the multivariable model, hyperphosphatemia conferred a higher probability of target organ damage (OR [95% CI]: 2.43 [2.06–2.86]), while moderate hypophosphatemia conferred a lower probability (OR [95% CI]: 0.73 [0.65–0.82]), compared to normal phosphate levels and extreme hypophosphatemia showed a non-significant association (OR [95% CI]: 0.87 [0.57–1.28]). The associations were independent of renal failure. In a multivariable model, hyperphosphatemia was associated with a slight increase of 0.33 days in length of stay compared to normal phosphate levels.ConclusionA J-shaped relation was found between phosphate levels and prognosis in patients hospitalized with infectious diseases, regardless of their renal function.
Enterococcus casseliflavus regulates amino acid metabolism in edible insect Clanis bilineata tsingtauica: a functional metagenomics study
Authors: Qian Lei , Wang Yanhui , Deng Pan , Zhang Jia , Qin Yi , Li Zongnan , Liao Huaijian , Chen Fajun 
Published: March 2024

IntroductionThe soybean hawkmoth, Clanis bilineata tsingtauica, is an edible insect that possesses high nutritional, medicinal and economic value. It has developed into a characteristic agricultural industry in China.MethodsThe dominant gut bacterium in diapause larvae of soybean hawkmoths was identified by metagenomics, and the effect of diapause time on gut microbiome composition, diversity and function was investigated.ResultsEnterococcus and Enterobacter were measured to be the dominant genera, with Enterococcus casseliflavus and Enterococcus pernyi being the dominant species. Compared to the controls, the relative abundance of E. casseliflavus and E. pernyi on day 14 was lower by 54.51 and 42.45%, respectively. However, the species richness (including the index of Chao and ACE) of gut microbiota increased on day 28 compared to controls. The gene function was mainly focused on carbohydrate and amino acid metabolism. Metabolic pathways annotated for amino acids on day 14 increased by 9.83% compared to controls. It is speculated that diapause soybean hawkmoths may up-regulate amino acid metabolism by reducing E. casseliflavus abundance to maintain their nutritional balance. Additionally, tetracycline, chloromycetin and ampicillin were screened as the top three antibiotics against E. casseliflavus.DiscussionThis study not only extends our knowledge of gut microbiome in soybean hawkmoths at the species level, but also provides an initial investigation of gene functionality in interaction with insect hosts.