bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional activation ofBmal1drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress
Authors: Ge Yi-Ling , Liu Yong , Zhang Bin , Xu Jin , He Si-Yuan , Cao Qing-Lin , Li Pei-Jie , Bu Ying-Rui , Bai Yun-Gang , Zhang Lin , Yu Zhi-Bin , Xie Man-Jiang 
Published: April 2024

AbstractBackgroundHypoxic stress-induced inflammation had been considered to play an important role in the onset and progression of altitude-related illnesses, but the origin of inflammatory cytokines, the specific responding cell types, and molecular mechanisms remain unknown. Mitochondria are responsible for oxygen consumption and recently reported to be the master regulators of inflammation, but it is not clear whether and how mitochondrial organelles sense the hypoxic stress and then control the inflammation.MethodsHuman subjects and mouse models were exposed to real or simulated altitude of 5500 m. Bone marrow-derived macrophages (BMDMs) and monocyte RAW264.7 cells were cultured under 1% oxygen hypoxic conditions. Myeloid-specificBmal1knock-out mice were generated by crossingBmal1flox/floxmice with Lyz2-Cre mice. Inflammation was investigated by assessing inflammatory mediators, monocyte activities, and leukocyte infiltrating. Mitochondrial unfolded protein response was examined by measuring stress markers, such as LONP1, AFG3L2, and HSP60. The target molecular mechanisms were identified by performing bioinformatic analyses, ChIP assays, and gain/loss-of-function experiments.Results1) Monocytes in peripheral blood mononuclear cell (PBMCs) were more sensitive and contributed promptly to circulating inflammation in response to acute hypobaric hypoxia. 2) Hypoxic stress triggered the mitochondrial unfolded protein response and then induced the mito-inflammation (NLRP3 inflammasome) in monocytes. 3) Activation ofBmal1drove mitochondrial stress and mito-inflammation by promoting Fis1-mediated mitochondrial fission in monocytes under hypoxia. 4) BHLHE40, a stress-responsive transcription factor directly targeted by HIF-1α, stimulatedBmal1transcription in monocytes under hypobaric hypoxia. 5) Myeloid-specificBmal1deletion alleviated systemic circulating and vascular inflammation under acute hypobaric hypoxia.ConclusionBHLHE40, a transcription factor associated with hypoxia, stimulatedBmal1, which in turn triggered the mitochondrial unfolded protein response and drove the mito-inflammation in monocytes by promoting Fis1-mediated mitochondrial fission. Our work provides a novel mechanism which may develop the circadian targeting drugs for altitude or hypoxia-related diseases.
PPP project price mode typologies: a China-based comparative case study
Authors: Guo Yubo , Liu Jinchan , Chen Chuan , Luo Xiaowei , Martek Igor 
Published: April 2024

PurposePublic–Private Partnerships (PPPs) are crucial to the procurement of global infrastructure projects. Moreover, a price mode based on a cluster of core concessionary items is key to the delivery of value-for-money and successful project outcomes. However, existing research has yet to fully identify PPP concessionary items, nor yet described the range of practical price modes. This study provides taxonomy of core concessionary items impacting PPP projects, systematically classifies price modes, and assesses the applicability and risk impacts of those price modes on PPP projects.Design/methodology/approachThis study adopts a comparative case study method in analyzing core concessionary items and alternative price modes. China is taken as the context, as it is one of the world’s largest PPP markets. In ensuring research validity and reliability, diverse data sources are utilized, with a graphic content analysis tool developed to capture the structure of price modes.FindingsEight PPP price modes are identified. These are: (1) UP (Unit Price) mode, (2) ALS (Annual Lump Sum) mode, (3) IRR (Internal Rate of Return) mode, (4) RP (Return for Investing Capital (RIC) - Profit Rate of O&M (PROM)) mode, (5) RFP (RIC - Financing Interest Rate (FR) - PROM) mode, (6) RFPL (RIC - FR - PROM - Lower Limit of User Charge (LLoUC)) mode, (7) RFL (RIC - FR - Lump Sum/Fixed Unit Price O&M Contract (LSOM/FUP)) mode, and (8) RFLL (RIC - FR - LSOM/FUP - LLoUC) mode. Other main findings are as follows: (1) Five risk allocation configurations can be achieved via these price modes. Yet while different price modes enable the allocation of specific risks, these do not always align with contracting parties’ original intentions. (2) IRR and RP modes may be less applicable in general because of their vulnerability in allocating critical risks and capacity for spurring opportunistic behavior.Originality/valueBy depicting the paths by which concessionary items in price modes affect cash flow, a systematic analysis of price modes was conducted exposing structural characteristics, along with risk allocation choice implications. The study is unique in: (1) Providing a systematic classification of PPP price modes used in PPP projects, (2) Presenting a comprehensive identification and streamlining of concessionary items in PPP practice, and (3) Analyzing the risk effects of different price modes. Together, these outcomes offer a hitherto unavailable perspective on PPP project risk management. The value of the study lies in the following: (1) Existing studies employ diverse concessionary items, but their applicability varies. This study offers an overarching framework facilitating decision-making in selecting appropriate PPP price modes and in determining concessionary items. (2) This study adds to the understanding of PPP price modes in significant ways that will aid local governments and potential sponsors in crafting and administrating more workable contract designs.
Digital literacy: a pathway toward empowering rural women
Authors: Kumar Suneel , Kumar Varinder , Devi Nisha 
Published: April 2024

Purpose
This study aims to investigate the connection between digital literacy and women’s empowerment in the rural Himachal Pradesh. It explores how improved digital skills contribute to increased empowerment among women with a specific focus on the role of education in enhancing digital literacy.

Design/methodology/approach
This study included 250 rural participants who completed structured questionnaires. Analytical tools, including independent-sample t-tests and partial least squares structural equation modeling, were applied to the data to gain insights into the relationship between digital literacy and women’s empowerment.

Findings
This study revealed a significant positive link between digital literacy and women’s empowerment in the rural Himachal Pradesh context. Education has emerged as a key factor that influences women’s digital skills and empowerment levels.

Originality/value
This research adds novelty by examining the digital literacy–women’s empowerment nexus in rural Himachal Pradesh and emphasizing the impact of education. The combination of statistical methods offers a robust approach to understanding this relationship and underscores the importance of digital inclusion and education for gender equality and women’s progress.
Front-line lean leader capacities, practices and effects on implementing tools: a survey of leaders in industrial companies
Authors: Simões Julianita Maria Scaranello , Toledo José Carlos de , Lizarelli Fabiane Letícia 
Published: April 2024

Purpose
Front-line lean leadership is critical for implementing and sustaining lean production systems (LPS). The purpose of this paper is to analyze the relationships between front-line lean leader (FLL) capacities (cognitive, social, motivational, knowledge and experience), lean leader practices (developing people and supporting daily kaizen) and the degree of implementation of lean tools (pull system, involvement of employees and process control) in manufacturing companies.

Design/methodology/approach
A survey was conducted with FLLs from large Brazilian manufacturing companies. The survey collected 103 responses, 99 of which were validated. Data were analyzed using partial least squares structural equation modeling.

Findings
There was a positive, significant and direct relationship between FLL capacities, leadership practices and a degree of implementation of LPS tools on the shop floor. The validated model is a reference base for planning FLL capacities and practices that result in more effectively implementing LPS on the shop floor.

Practical implications
The findings provide managers with a new perspective on the importance of the development and training of FLLs focusing on leadership capacities. As decisions about developing lean capabilities impact the application of Lean leadership practices and the use of lean tools, they are also related to day-to-day lean activities and improved operational results. Additionally, the proposed model can be used by managers as a basis to diagnose, develop and select lean leaders.

Originality/value
This study seeks to fill a theoretical gap of knowledge on front-line lean leadership as it jointly addresses and empirically analyzes the existing relationships between lean leadership capacities, encompassing the perspective of psychology, lean practices and tools on the shop floor.
GethReplayer: a smart contract testing method based on transaction replay
Authors: Shi Xiaohong , Wang Ziyan , Zhong Runlu , Ma Liangliang , Chen Xiangping , Yang Peng 
Published: April 2024

Purpose
Smart contracts are written in high-level programming languages, compiled into Ethereum Virtual Machine (EVM) bytecode, deployed onto blockchain systems and called with the corresponding address by transactions. The deployed smart contracts are immutable, even if there are bugs or vulnerabilities. Therefore, it is critical to verify smart contracts before deployment. This paper aims to help developers effectively and efficiently locate potential defects in smart contracts.

Design/methodology/approach
GethReplayer, a smart contract testing method based on transaction replay, is proposed. It constructs a parallel transaction execution environment with two virtual machines to compare the execution results. It uses the real existing transaction data on Ethereum and the source code of the tested smart contacts as inputs, conditionally substitutes the bytecode of the tested smart contract input into the testing EVM, and then monitors the environmental information to check the correctness of the contract.

Findings
Experiments verified that the proposed method is effective in smart contract testing. Virtual environmental information has a significant effect on the success of transaction replay, which is the basis for the performance of the method. The efficiency of error locating was approximately 14 times faster with the proposed method than without. In addition, the proposed method supports gas consumption analysis.

Originality/value
This paper addresses the difficulty that developers encounter in testing smart contracts before deployment and focuses on helping develop smart contracts with as few defects as possible. GethReplayer is expected to be an alternative solution for smart contract testing and provide inspiration for further research.
Sustainability scoring tool for real estate according to German and European valuation principles in the purchasing process
Authors: Oktabec Katharina , Wills Nadine 
Published: April 2024

PurposeSustainability has become an integral part of the real estate industry, alongside advancing globalization and demographic development. Due to real estate's influence on greenhouse gas emissions throughout its life cycle, both the regulatory and legal requirements concerning the sustainability of real estate are growing and, as a result of social responsibility, the interest of tenants and investors in sustainable real estate. However, criteria for measuring the ecological sustainability of a real estate investment in the purchase process in order to reduce the risk of including “stranded assets” in the portfolio are missing. This paper aims to address the need to integrate the issue of carbon stranding into existing sustainability rating tools.Design/methodology/approachExisting tools are examined based on defined criteria to determine whether they are suitable for purchasing a property before suitable tools for purchase are compared. Strengths and weaknesses are identified, which are to be remedied with the scoring tool. Taxonomy regulation is integrated into the existing valuation basis as a legal regulation.FindingsThe result is a scoring tool that enables real estate companies to measure and evaluate the ecological sustainability performance of a property during the acquisition process, taking into account the three aspects of sustainability and considering them when determining an appropriate purchase price in line with market conditions. Moreover, the developed tool helps to minimize the risk of acquiring a stranding asset.Research limitations/implicationsThe environmental, social and governance (ESG) framework employed in this study does not incorporate governance considerations. While the analysis extensively evaluates the building's environmental and social aspects, it does not extend to examining the governance practices of the companies involved. Thus, the assessment is confined solely to the physical attributes of the property without accounting for broader corporate governance factors.Practical implicationsThe developed scoring tool represents a valuable tool for the real estate industry, offering insights into sustainability performance during property acquisitions and providing a structured framework for decision-making. By addressing both certification and taxonomy regulation requirements, the tool contributes to the industry's evolution toward more sustainable and environmentally responsible real estate practices.Originality/valueIn response to the growing importance of sustainability in the real estate industry, this paper introduces a novel scoring tool for evaluating the sustainability of real estate investments during the acquisition process.
Why building a mentoring culture can be transformational
Authors: Parsloe Ed 
Published: April 2024

Purpose
This paper aims to explore why creating a mentoring culture can help to transform businesses and solve key recruitment, training and development and retention issues. It looks at what a mentoring culture is and the benefits and provides advice for companies on how to build this kind of culture.

Design/methodology/approach
This paper considers the approach taken by leadership coaching company The OCM to develop effective coaching and mentoring programmes which can contribute to organisational success in an ever-changing business environment. This paper explores current business challenges and how they can be overcome.

Findings
Creating a mentoring culture can transform a business. It can address many talent and leadership-based challenges and tap into the potential of knowledge transfer across a multi-generational workplace. The paper includes two case studies of organisations whose experiences of mentoring and coaching have been overwhelmingly positive and led to much-needed cultural shifts.

Originality/value
This paper attempts to raise awareness of the benefits of mentoring and coaching as an effective method for attracting, developing and retaining people and meeting the challenges of a modern workplace.
Similar trait‐based successional assembly in native and introduced plants despite species pool differences
Authors: Poddar Urmi , Gurevitch Jessica , Meiners Scott J. , D'Andrea Rafael 
Published: April 2024

Abstract

What drives the composition of invaded communities and the local abundance of introduced species are key questions in ecology.

Community‐assembly theory provides a useful framework for addressing these questions. Specifically, the environmental filtering model of community assembly predicts that a species' presence and abundance in a community depend on the interaction between its functional traits and the local environmental filters. However, for introduced species, larger‐scale dispersal and introduction‐related filters may restrict their regional trait pool.

Here, we tested this framework using long‐term data from 50+ years of old‐field vegetation succession. We asked whether native and introduced plant assemblages followed the same trait‐based assembly rules. We also asked whether local functional dissimilarities between the two can be explained by regional species pool differences, a possibility that has rarely been addressed.

We found strong similarities in the assembly processes of native and introduced plants. Average height and seed mass of both groups increased over time, consistent with previous studies of old‐field succession. Moreover, the two showed similar trait–abundance relationships. While there were also some differences, particularly in their trait–incidence relationships, these differences appeared to be minor.

Furthermore, we identified species pool constraints on introduced species and found that the exotic species pool was biased towards early successional traits.

Lastly, we found that highly invasive exotic species were also likely to deviate from the expected trait–abundance relationship, suggesting a link between the two.

These results imply that introduced species generally follow the same assembly rules as native species. They also indicate that species pool differences can result in local functional composition differences, even when the two groups follow the same assembly rules. Moreover, there may be a link between species invasiveness and deviation from assembly rules, which, if further confirmed, provides a potential method of identifying strong invaders.

Synthesis: Using data from a long‐term succession study, we showed several similarities, and some differences, in the assembly of native and introduced species assemblages. Our results provide a better understanding of the factors constraining and allowing invasion, and help in the identification of ‘rule breaking’ invaders.
Online polarization and identity politics: An analysis of Facebook discourse on Muslim and LGBTQ+ communities in Finland
Authors: Unlu Ali , Kotonen Tommi 
Published: April 2024

AbstractThis study employs a mixed‐methods approach to investigate the nature of Facebook posts related to Muslims and LGBTQ+ individuals in Finland, spanning a period of 4 years. Through the use of the CrowdTangle platform, the researchers extracted and analyzed Facebook posts that encompassed predetermined keywords indicative of potential hate speech. The findings underscored divergent patterns of engagement and sentiment toward these two groups, with implications for the different levels of societal acceptance and tolerance exhibited. Posts related to Muslims typically elicited controversy and were often depicted as threats, whereas posts about the LGBTQ+ community generally advocated for inclusivity. However, persistent negative stereotypes about the LGBTQ+ community were also evident. The analysis also brought to light how political parties strategically used these discourses to steer conversations, consolidate their ideological positions, and mobilize their respective supporters. Grounded in the social identity theory, this study sheds light on the complex dynamics of online political discourse, revealing its far‐reaching impacts on societal attitudes, intergroup relations, and formation of group identities. The nuanced understanding derived from these observations suggests that interventions fostering healthier public discussions on social media platforms could contribute significantly to combating societal division, prejudice, and bias. This research underscores the importance of scrutinizing online discourses to address issues of societal cohesion and social acceptance.
Religious suasion: introduction to the special issue
Authors: Cardoza Danny , Victor Sam 
Published: April 2024

AbstractIn this introduction, we outline a comparative tool for studying communicative ideologies and practices, which we call ‘religious suasion’. Developing a conversation about religious forms of ‘suasion’ is important because it provides a vocabulary for comparing parallel practices of religious influence across different religious communities, allowing for more nuanced understandings of what might commonly – and negatively – be termed ‘proselytizing’. The proposed analytical frame is not concerned with how the ‘convert’ might experience religious change, nor with how social and religious change unfolds on a grand scale. Rather, it interrogates and puts into dialogue multiple forms of discursive practice, demonstrations of virtue, and material forms of religion to reach beyond suasive strategies based on formal doctrines about religious propagation that tend to be associated with traditionally evangelistic religious communities, especially with Christianity. Focusing on the rhetorical strategies, religious imaginaries, and ethical evaluations that underpin how religious actors pursue change in others and in and of the world, ‘religious suasion’ contributes to the development of an anthropology of influence.
‘Levelling up’ social mobility? Comparing the social and spatial mobility for university graduates across districts of Britain
Authors: Yu Yang , Gamsu Sol , Forsberg Håkan 
Published: April 2024

AbstractSocial and spatial mobility have been subject to substantial recent sociological and policy debate. Complementing other recent work, in this paper we explore these patterns in relation to higher education. Making use of high‐quality data from the higher education statistics agency (HESA), we ran a set of multilevel models to test whether the local authority areas where young people grow up influence social and spatial mobility into a higher professional or managerial job on graduation. We found entry to these patterns reflect pre‐existing geographies of wealth and income, with more affluent rural and suburban areas in South‐East England having higher levels of entry to these occupations. Graduates clustered from major cities tended to be spatially immobile and those from peripheral areas further away from these cities show a higher density of long‐distance moves following graduation. We also explored the intersection between social and spatial mobility for graduates with the economic geography of Britain, showing that access to high‐class occupations is not necessarily associated with long‐distance moves across most British districts. Our evidence further suggests that the ‘London effect’, where working‐class students have higher school attainment than their peers elsewhere, may not continue through to graduate employment.
Anticoagulant properties and therapeutic potentials of wasp venom
Authors: Choi Moon Bo , Lee Yong‐Ho 
Published: April 2024

AbstractWasp venom is rich in bioactive substances, such as proteins, peptides, and small molecules. The venom significantly affects the mammalian cardiovascular, nervous, and immune systems, causing mild to severe symptoms following stings. It exhibits both procoagulant and anticoagulant activities, and significant research has identified its ability to modulate the mammalian coagulation system. Active substances that inhibit clotting have been identified and purified through patient case reports and experimental studies. This study reviewed the findings on how wasp venom interacts with platelets and coagulation factors, such as fibrinogen and prothrombin, and demonstrated its dual influence on the coagulation cascade. This highlights the potential of the venom in therapeutic applications, especially as an anticoagulant, as evidenced by the inhibition of coagulation factors and prolonged clotting times after envenomation, suggesting its utility in developing novel anticoagulant therapies. This review focuses on the anticoagulant effects of social wasp venom, which is prevalent in sting incidents, summarizing the research and observations on its therapeutic potential. This emphasizes the significance of further studies to identify and utilize venom components as innovative anticoagulant treatments.