bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Geography of Human Capital: Insights from the Subnational Human Capital Index in Indonesia
Authors: Sari Virgi Agita , Tiwari Sailesh 
Published: March 2024

AbstractThis paper explores the spatial heterogeneity in the human capital potential of Indonesia’s next generation by constructing and analyzing sub-national human capital indices (HCI) for 34 provinces and 514 districts in Indonesia. The paper identifies data and methodological constraints in the construction of these sub-national indices and proposes and implements strategies to overcome these challenges. Several interesting findings emerge from the analysis. First, Indonesian’s young generation can only achieve 53% of their future productivity relative to the full benchmark of health and education. Second, the variation in aggregate human capital potential across space in Indonesia is staggering: some parts of country are almost at par with countries like Vietnam and China while others have human capital levels that are comparable to Chad, Niger, and Sierra Leone. Third, differences in learning outcomes as measured by harmonized test scores account for the largest share of the variation in human capital across Indonesia, suggesting that the challenge of providing quality education remains one of the most important obstacles to equalizing opportunities for the next generation of Indonesians. And fourth, the correlation between government spending and performance on HCI at the district level appears rather weak, reinforcing conclusions reached by other recent studies that have highlighted the importance of focusing on the quality of spending. Finally, this paper also shows that Indonesia’s human capital registered a modest improvement from 0.50 in 2013 to 0.53 in 2018 with stronger progress observed among the already top performing provinces.
Mars Express: 20 Years of Mission, Science Operations and Data Archiving
Authors: Cardesin-Moinelo A. , Godfrey J. , Grotheer E. , Blake R. , Damiani S. , Wood S. , Dressler T. , Bruno M. , Johnstone A. , Lucas L. , Marin-Yaseli de la Parra J. , Merritt D. , Sierra M. , Määttänen A. , Antoja-Lleonart G. , Breitfellner M. , Muniz C. , Nespoli F. , Riu L. , Ashman M. , Escalante A. , Geiger B. , Heather D. , Hepburn A. , Pistone V. , Raga F. , Valles R. , Companys V. , Martin P. , Wilson C. 
Published: March 2024

AbstractLaunched on 2 June 2003 and arriving at Mars on 25 December 2003 after a 7-month interplanetary cruise, Mars Express was the European Space Agency’s first mission to arrive at another planet. After more than 20 years in orbit, the spacecraft and science payload remain in good health and the mission has become the second oldest operational planetary orbiter after Mars Odyssey.This contribution summarizes the Mars Express mission operations, science planning and data archiving systems, processes, and teams that are necessary to run the mission, plan the scientific observations, and execute all necessary commands. It also describes the data download, the ground processing and distribution to the scientific community for the study and analysis of Mars sub-surface, surface, atmosphere, magnetosphere, and moons.This manuscript also describes the main challenges throughout the history of the mission, including several potentially mission-ending anomalies. We summarize the evolution of the ground segment to provide new capabilities not envisaged before launch, whilst simultaneously maintaining or even increasing the quality and quantity of scientific data generated.
Mechanisms of Pore-Clogging Using a High-Resolution CFD-DEM Colloid Transport Model
Authors: Liu Shitao , Shikhov Igor , Arns Christoph 
Published: March 2024

AbstractColloidal transport and clogging in porous media is a phenomenon of critical importance in many branches of applied sciences and engineering. It involves multiple types of interactions that span from the sub-colloid scale (electrochemical interactions) up to the pore-scale (bridging), thus challenging the development of representative modelling. So far published simulation results of colloidal or particulate transport are based on either reduced set of forces or spatial dimensions. Here we present an approach enabling to overcome both computational and physical limitations posed by a problem of 3D colloidal transport in porous media. An adaptive octree mesh is introduced to a coupled CFD and DEM method while enabling tracking of individual colloids. Flow fields are calculated at a coarser scale throughout the domain, and at fine-scale around colloids. The approach accounts for all major interactions in such a system: elastic, electrostatic, and hydrodynamic forces acting between colloids, as well as colloids and the collector surface. The method is demonstrated for a single throat model made of four spherical segments, and the impact of clogging is reported in terms of the evolution of the critical path diameter for percolation and permeability. We identified four stages of clogging development depending on position and time of individual colloid entrapment, which in turn correlates to a cluster evolution and local transport.
Development of New CD38 Targeted Peptides for Cancer Imaging
Authors: Zheleznyak Alexander , Tang Rui , Duncan Kathleen , Manion Brad , Liang Kexian , Xu Baogang , Vanover Alexander , Ghai Anchal , Prior Julie , Lees Stephen , Achilefu Samuel , Kelly Kimberly , Shokeen Monica 
Published: March 2024

Abstract
Purpose
Multiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emission Tomography (PET) tracers for the detection, accurate staging, and monitoring of treatment response of MM that have optimal specificity and translational attributes. CD38 is uniformly overexpressed in MM and thus represents an ideal target to develop CD38-targeted small molecule PET radiopharmaceuticals to address these challenges.

Procedures
Using phage display peptide libraries and pioneering algorithms, we identified novel CD38 specific peptides. Imaging bioconjugates were synthesized using solid phase peptide chemistry, and systematically analyzed in vitro and in vivo in relevant MM systems.

Results
The CD38-targeted bioconjugates were radiolabeled with copper-64 (64Cu) with100% radiochemical purity and an average specific activity of 3.3 – 6.6 MBq/nmol. The analog NODAGA-PEG4-SL022-GGS (SL022: Thr-His-Tyr-Pro-Ile-Val-Ile) had a Kd of 7.55 ± 0.291 nM and was chosen as the lead candidate. 64Cu-NODAGA-PEG4-SL022-GGS demonstrated high binding affinity to CD38 expressing human myeloma MM.1S-CBR-GFP-WT cells, which was blocked by the non-radiolabeled version of the peptide analog and anti-CD38 clinical antibodies, daratumumab and isatuximab, by 58%, 73%, and 78%, respectively. The CD38 positive MM.1S-CBR-GFP-WT cells had > 68% enhanced cellular binding when compared to MM.1S-CBR-GFP-KO cells devoid of CD38. Furthermore, our new CD38-targeted radiopharmaceutical allowed visualization of tumors located in marrow rich bones, remaining there for up to 4 h. Clearance from non-target organs occurred within 60 min. Quantitative PET data from a murine disseminated tumor model showed significantly higher accumulation in the bones of tumor-bearing animals compared to tumor-naïve animals (SUVmax 2.06 ± 0.4 versus 1.24 ± 0.4, P = 0.02). Independently, tumor uptake of the target compound was significantly higher (P = 0.003) compared to the scrambled peptide, 64Cu-NODAGA-PEG4-SL041-GGS (SL041: Thr-Tyr-His-Ile-Pro-Ile-Val). The subcutaneous MM model demonstrated significantly higher accumulation in tumors compared to muscle at 1 and 4 h after tracer administration (SUVmax 0.8 ± 0.2 and 0.14 ± 0.04, P = 0.04 at 1 h; SUVmax 0.89 ± 0.01 and 0.09 ± 0.01, P = 0.0002 at 4 h).

Conclusions
The novel CD38-targeted, radiolabeled bioconjugates were specific and allowed visualization of MM, providing a starting point for the clinical translation of such tracers for the detection of MM.
Deprivation and Its Association with Child Health and Nutrition in the Greater Kampala Metropolitan Area of Uganda
Authors: Kananura Rornald Muhumuza , Waiswa Peter , Wasswa Ronald , Boerma Ties , Blumenberg Cauane , Maiga Abdoulaye 
Published: March 2024

AbstractAfrican cities are experiencing increasing living standard disparities with limited evidence of intra-urban health disparities. Using data from the 2006–2016 Uganda Demographic and Health Surveys, we employed the UN-Habitat definition to examine slum-like household conditions in the Greater Kampala Metropolitan Area (GKMA). Subsequently, we developed a slum-like severity index and assessed its association with under-5 common morbidities and healthcare access. We also assessed the characteristics of people in slum-like household conditions. We identified five slum-like conditions: substandard housing conditions, limited water access, overcrowding, unclean cooking fuel, and limited toilet access. By 2016, 67% of GKMA households were classified as slum-like conditions, including 31% in severe conditions. Limited toilet access, overcrowding, and limited water access were the main forms of deprivation.Living in slum-like household conditions correlated with lower education levels, youth status, unprofessional jobs, and marriage. Compared to neighboring Kampala city urban outskirts, Kampala city households had lower slum-like prevalence. Children in GKMA living in slum-like household conditions were more likely to experience diarrhea (moderate: OR = 1.21[95% CI: 1.05–1.39], severe: OR = 1.47 [95% CI: 1.27–1.7]); fever (moderate: OR = 2.67 [95% CI: 1.23–5.8], severe: OR = 3.09 [95% CI: 1.63–5.85]); anemia (moderate: OR = 1.18 [95% CI: 0.88–1.58], severe: OR = 1.44 [95% CI: 1.11–1.86]); and stunting (moderate: OR = 1.23 [95% CI: 1.23–1.25], severe: OR = 1.40 [95% CI: 1.41–1.47]) compared to those living in less slum-like conditions. However, seeking treatment for fever was less likely in slum-like household conditions, and the association of slum-like household conditions with diarrhea was insignificant. These findings underscore the precarious urban living conditions and the need for targeted health interventions addressing the social determinants of health in urban settings.
Ovarian Suppression: Early Menopause and Late Effects
Authors: Molinelli Chiara , Jacobs Flavia , Nader-Marta Guilherme , Borea Roberto , Scavone Graziana , Ottonello Silvia , Fregatti Piero , Villarreal-Garza Cynthia , Bajpai Jyoti , Kim Hee Jeong , Puglisi Silvia , de Azambuja Evandro , Lambertini Matteo 
Published: March 2024

Opinion statementAround 90% of breast tumours are diagnosed in the early stage, with approximately 70% being hormone receptor-positive. The cornerstone of adjuvant therapy for early-stage hormone receptor-positive breast cancer is endocrine therapy, tailored according to disease stage, biological characteristics of the tumour, patient’s comorbidities, preferences and age. In premenopausal patients with hormone receptor-positive breast cancer, ovarian function suppression is a key component of the adjuvant endocrine treatment in combination with an aromatase inhibitor or tamoxifen. Moreover, it can be used during chemotherapy as a standard strategy for ovarian function preservation in all breast cancer subtypes. In the metastatic setting, ovarian function suppression should be used in all premenopausal patients with hormone receptor-positive breast cancer to achieve a post-menopausal status. Despite its efficacy, ovarian function suppression may lead to several side effects that can have a major negative impact on patients’ quality of life if not properly managed (e.g. hot flashes, depression, cognitive impairment, osteoporosis, sexual dysfunction, weight gain). A deep knowledge of the side effects of ovarian function suppression is necessary for clinicians. A correct counselling in this regard and proactive management should be considered a fundamental part of survivorship care to improve treatment adherence and patients’ quality of life.
Trends of Satellite-Derived Thermal Fronts in the Southeast and Southwest of Australia Between 1993 and 2019
Authors: Yang Kai , Fischer Andrew M. , Govekar Pallavi 
Published: March 2024

AbstractOceanic fronts play a significant role in marine ecosystems by enhancing vertical exchange, promoting the aggregation of plankton, and drawdown of organic carbon. Anthropogenic emission of carbon dioxide and other greenhouse gases in the twentieth century has driven global warming, leading to rising ocean temperatures. Specific regions warming faster than the global average—known as ‘ocean warming hotspots’—have been identified, impacting geophysical and biogeochemical dynamics of local ecosystems. Here, we aim to characterize the variability of sea surface temperature (SST) fronts in the southeast and southwest Australia hotspots. Using a histogram frontal detection method, we derived fronts from AVHRR-only and Multi-sensor 6-day SST composites on a 0.02 × 0.02 grid between January 1993 and December 2019. Our results indicate that frontal frequency and frontal density have increased in both regions in the past three decades, by around 0.2–0.3%. In addition, both regions exhibit higher frequency and density of fronts in austral winter and fewer in austral summer. Our calculations show that changes in frontal frequency/density show some relationship to El Niño-Southern Oscillation and Indian Ocean Dipole. Changes in frontal activity could strongly impact local ocean biogeochemistry and marine ecosystems. A better understanding changing fronts in hotspots will help predict and manage future changes in regional oceans to warming.
Virtual reality games for 3D multimodal designing and knowledge across the curriculum
Authors: Mills Kathy A. , Brown Alinta , Funnell Patricia 
Published: March 2024

AbstractImmersive virtual reality (VR) is anticipated to peak in development this decade bringing new opportunities for 3D multimodal designing across all levels of education. The need for students to gain capabilities with multimodal texts—texts that combine two or more modes, such as spoken, written, and visual—is emphasised at all levels of education from P-12 in the Australian Curriculum. Likewise, the use of technology-supported pedagogies is increasing worldwide, rendering multimodal texts ubiquitous across all knowledge domains. This original, qualitative classroom research investigated students’ 3D designing of multimodal texts using an immersive VR head-mounted display. Upper primary students (ages 10–12 years, n = 48) transferred their knowledge of ancient Rome through 2D drawing, writing, speaking, and 3D multimodal designing with VR. The application of multimodal analysis to video data, screen recordings, and think-aloud protocols, and the thematic coding of student and teacher interviews yielded four key findings: (i) VR gaming supported 3D multimodal designing through haptic and embodied experience, (ii) VR improved performance through creative redesigning, (iii) VR-supported knowledge application, consolidation, and transfer, and (iv) pedagogical strengths of VR were situated and transformed practice. This research is timely and significant given the increasing accessibility and affordability of VR and the need to connect research and pedagogical practice to support students’ advanced knowledge and capabilities with multimodal learning across the curriculum.
Towards Sustainable Pest Management: Toxicity, Biochemical Effects, and Molecular Docking Analysis of Ocimum basilicum (Lamiaceae) Essential Oil on Agrotis ipsilon and Spodoptera littoralis (Lepidoptera: Noctuidae)
Authors: Awad Mona , Alfuhaid Nawal Abdulaziz , Amer Alia , Hassan Nancy N. , Moustafa Moataz A. M. 
Published: March 2024

AbstractOver the last decade, essential oils (EOs) have become potential ingredients for insecticide formulations due to their widespread availability and perceived safety. Therefore, this study aimed to evaluate the toxicity and biochemical efficacy of basil (Ocimum basilicum) (Lamiaceae) against two destructive pests Noctuidae, Agrotis ipsilon (Hufnagel) and Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae). In addition, a molecular docking study was performed to gain insight into the binding pattern between glutathione S-transferase (GST) and linalool, the main component of EO. GC–MS analysis of O. basilicum EO revealed that linalool is the most abundant compound (29.34%). However, the toxicity tests showed no significant difference between the values of LC50 of O. basilicum EO to A. ipsilon and S. littoralis. On the other hand, the sublethal experiments indicated that treating the second instar larvae with LC15 or LC50 values of O. basilicum EO significantly prolonged the larval duration in both insects, compared to the control. Regarding the biochemical effect of O. basilicum EO, the treatments significantly impacted the activity of detoxification enzymes. A notable elevation in glutathione S-transferase (GST) activity was recorded in A. ipsilon larvae compared with a reduction in S. littoralis larvae. The molecular docking analysis revealed that linalool bonded with the amino acid serine (SER 9) of GST, indicating its binding affinity with the enzyme. The obtained results could offer valuable insights into the mode of action of O. basilicum and can encourage the adoption of sustainable pest control practices that incorporate essential oils.
“Well, that Was Pretty Clever!”—Ethnic Minority Women’s Views on HPV Self-Sampling Devices for Cervical Cancer Screening: Attitudes to Brushes, First-Void Urine, and Menstrual Blood Devices
Authors: Hald Signe Ruby , Tatari Camilla Rahr , Kirkegaard Pia , Tranberg Mette , Andersen Berit , Nielsen Camilla Palmhøj 
Published: March 2024

Abstract
Background
Ethnic minority women are less likely to participate in cervical cancer uteri (CCU) screening compared to native women. Human Papillomavirus (HPV) self-sampling kits for CCU screening may be a potential strategy to increase participation. This study aimed to explore views and attitudes on four different types of self-sampling kits (two brushes, a first-void urine device, and a menstrual blood device) among non-Western ethnic minority women living in Denmark.

Methods
The study was a social science single case study based on focus group interviews with 30 women aged 32–54 with non-Western background from a deprived area. A phenomenological approach was applied to describe the phenomenon “self-sampling” as seen from the women’s lifeworlds. The interviews were transcribed verbatim and analysed using systematic text condensation.

Results
The women expressed significant interest in the possibility of using HPV self-sampling kits as an alternative to being screened by their general practitioner. They were particularly motivated to use the non-invasive self-sampling kits for CCU screening as they were deemed suitable for addressing cultural beliefs related to their bodies and virginity. The women expressed interest in the use of the invasive self-sampling kits but were cautious, primarily due to lack of confidence in correctly performing self-sampling with a brush and due to cultural beliefs.

Conclusion
The use of non-invasive self-sampling kits, such as a first-void urine collection device and menstrual blood pad, represents a promising solution to overcome cultural barriers and promote greater equality in CCU screening participation among non-Western ethnic minority women.
In-situ alloying laser powder bed fusion of Ni-Mn-Ga magnetic shape memory alloy using liquid Ga
Authors: Milleret Anastassia , Laitinen Ville , Ullakko Kari , Fenineche Nouredine , Attallah Moataz M. 
Published: March 2024

AbstractNi-Mn-Ga-based magnetic shape memory alloys can exhibit large magnetic field induced strains (MFIS). Recently, additive manufacturing techniques, especially laser powder bed fusion (L-PBF), have been successfully used to manufacture functional polycrystalline Ni-Mn-Ga with complex geometries, such as ‘bamboo-grained’ lattice structures. However, previous approaches of L-PBF of Ni-Mn-Ga have used pre-alloyed powders, which can limit the compositional freedom of the manufactured devices. This study explores, for the first time, the feasibility of an in-situ L-PBF alloying approach using a powder blend of elemental Ni, Mn, and Ga. Promising results were obtained despite the significant differences between the elemental Ni and Mn powders and the liquid Ga. The microstructure of the as-built sample showed distinct stripe patterns from the 14 M structure confirmed by XRD analysis. Heat-treatment significantly improved chemical homogeneity, dissolved the Ni-rich phase but couldn’t dissolve MnO hindering the shape memory effect.
Post-configuration Activation of Hardware Trojans in FPGAs
Authors: Ahmed Qazi Arbab , Wiersema Tobias , Platzner Marco 
Published: March 2024

AbstractThe battle of developing hardware Trojans and corresponding countermeasures has taken adversaries towards ingenious ways of compromising hardware designs by circumventing even advanced testing and verification methods. Besides conventional methods of inserting Trojans into a design by a malicious entity, the design flow for field-programmable gate arrays (FPGAs) can also be surreptitiously compromised to perform successful attacks that result in malfunctions or information leakages. In this paper, we introduce a mechanism for the post-configuration activation of a Trojan that leverages malicious routing so that the attacker can leave the Trojan circuit in an undetectable dormant state even in the generated and transmitted bitstream. The Trojan is designed, for example, by adding an enable signal that is routed to an unused primary input/output of the FPGA or by attaching the payload via one route to the remaining design, and then that new route is disconnected during place-and-route and only re-connected when the FPGA is being programmed. The trigger can thus only be activated once the circuit is on the device, which leaves the Trojan dormant in all verification and pre-silicon testing steps. This Trojan can therefore currently neither be prevented by conventional testing and verification methods nor by bitstream-level verification techniques. Since our method ensures that the malicious circuitry is only active in the field, the approach works also quite well with triggerless (always-on) Trojans that have a negligible impact on the overall area and power consumption of the circuit and can thus easily escape detection by fingerprinting techniques using side-channel analyses.