bluuebunny/crossref_metadata_2025_split huggingface dataset:
In memory of Igor Nikolaevich Kiselyov (03/15/1947 - 01/19/2024)
Authors: Garskova Irina Markovna , Bobrova Elena Viktorovna , Borodkin Leonid Iosifovich , Vladimirov Vladimir Nikolaevich 
Published: April 2024

This memorial article is dedicated to the memory of Igor Nikolaevich Kiselyov, a man who did a lot in the field of informatization of historical science and archival business. Igor Nikolaevich started working as a quantifier historian, a specialist in the field related to the application of mathematical methods and computer technologies in historical research. He actively participated in research projects on historical demography and other areas of historical science, in 2002 for a series of works on the history of the Russian population in the 1930s, Yu.A. Polyakov, V.B. Zhiromskaya and I.N. Kiselyov were awarded the V.O. Klyuchevsky Prize of the Russian Academy of Sciences. In the 1990s, the main Igor Nikolaevich became interested in archival issues: issues of informatization of archival business, creation and analysis of online archival resources. Igor Nikolaevich was one of the leading experts in the field of historical informatics, was a member of the Council of the Association "History and Computer", conducted teaching work as an associate professor at the IAI of the Russian State University. The article uses the memoirs of colleagues, materials of publications by I.N.Kiselyov in historical journals, in the journals "Domestic Archives" and "Archivist's Bulletin", "AIK Newsletter". as well as materials about his leadership in the development of the Concept and Program for the Informatization of Archival Affairs in Russia, the first version of the Archives of Russia portal, and participation in many archival information projects. The article highly appreciates the research work of I.N.Kiselyov and his scientific and organizational activities at the Rosarchive, where he headed departments related to informatization, the organization of research work of the Federal Archival Service of Russia and the introduction of automated archival technologies. Igor Nikolaevich was seriously engaged in both theoretical and methodological problems of archival science. Literally until the last day, Igor Nikolaevich conducted active scientific and organizational work in breakthrough areas of archival science. His latest article "On the use of artificial intelligence in text recognition" was published in the first issue of the VNIIDAD Bulletin posthumously, and a joint scientific report "The use of artificial intelligence in document management in archives: practice, trends and prospects" was presented by his colleagues after Igor Nikolaevich passed away.
Fulminant Hepatitis Secondary to Anti-tuberculosis Drug-induced Hepatotoxicity Complication, Its Prevention Strategies and Management: A Case Report
Authors: Fjouji Salaheddine , Houba Abdelhafid , Chouikh Chakib , Rahali Imad , Bakkali Hicham , Doghmi Nawfal , Balkhi Hicham 
Published: April 2024

Aim: Tuberculosis remains a public health problem around the world. Hepatotoxicity is a serious side effect of anti-tuberculosis treatment. Fulminant hepatitis is a rare form but considered very serious outside of liver transplantation. It can occur several weeks or months after the start of treatment.
Presentation of Case: We report the case of a 34-year-old single male patient treated for pleural tuberculosis in whom fulminant hepatitis appeared after four months of treatment with Isoniazid and Rifampicin. Despite a treatment in intensive care unit He had a fatal outcome because of lack of liver transplantation.
Discussion: Hepatotoxicity varies from biological hepatitis to fulminant hepatitis. Application of personalized strategy of genetic analysis and pharmacological drug monitoring to optimize treatment is the most safe to avoid antituberculosis drug induced hepatotoxicity but not available in all healthcare centers of developing countries. There was any change of anti-tuberculosis protocol because of the risk of bacterial resistance. The protocol includes association between several medicines potentially toxics for a long duration. For some moderate forms of tuberculosis (nodals, pleural), it’s necessary to ask if duration of antiviotherapy can be reduced.
Conclusion: Prevention of hepatotoxicity starts with identifying risk factors, regular clinical and biological assessment and informing patients of symptom that can indicate toxicity to react early.
Family Factors Influencing Intentional Self-organophosphate Poisoning Among Persons of Age 15-30 Years in Kericho County, Kenya
Authors: Sigey Langat Kiprotich 
Published: April 2024

Aim: The aim of this study was to explore factors that influence intentional self-poisoning among patients aged 15-30 years in Kericho County. The study's specific goals were to explore the influence of family factors, on intentional self-organophosphate poisoning.
Study Design: The study adopted cross-sectional study design.
Place and Duration of Study: Study was conducted in Kericho County, health facilities for a period of 4 months.
Methodology: 100 respondents were included in the study (88 males and 12 females).
Sample size of 100 respondents was used which was estimated population of patients who might have been affected with poisoning during study period. Data was collected from respondents who were attended and recovered during the study period of four months.
Data Analysis: The collected quantitative data was analyzed using Statistical Package for Social Sciences (SPSS) version 21. Correlation and regression analysis were carried out to establish relationship between categorical variables. The analyzed data were presented in tables, charts and the corresponding thematic areas. Statistical significance was set at p<0.05.
Result: The results indicated that family factors showed positive influenced on self-poisoning. had correlation of 13.319 where significance was set at p=0.0001 indicating a high likelihood of influencing one to self-poison.
Conclusion: This study suggested counselors to have a prediction model to classify patients at a higher risk of self-harm by use of poisons and to focus on individual preventive strategies. Patients in the high-risk group require referral for mental health assessment and counseling both individual and family to alleviate helplessness and hopelessness, healthy lifestyle like come together party, and restriction of access to poison .This will eventually reduce these cases of self-poisoning in our Counties and Country at large.
Linum usitatissimum Hydroxynitrile Lyase Cross‐Linked Enzyme Aggregates: A Recyclable Enantioselective Catalyst
Authors: Cabirol Fabien L. , Tan Pei Loo , Tay Benson , Cheng Shiryn , Hanefeld Ulf , Sheldon Roger A. 
Published: October 2008

AbstractAn immobilized form of the hydroxynitrile lyase from Linum usitatissimum (LuHNL) as cross‐linked enzyme aggregate (CLEA) with high specific activity (303.5 U/g) and recovery (33%) was developed. Molecular imprinting using 2‐butanone as additive in the immobilization process improved the synthetic activity of the biocatalyst. LuCLEA could be partially recycled for the synthesis of (R)‐2‐butanone cyanohydrin on a preparative scale over two batches. The enantioenriched cyanohydrin obtained was further hydrolyzed to give (R)‐2‐hydroxy‐2‐methylbutyric acid in 85% yield (from 2‐butanone) and 87% ee.
Total Synthesis of (+)‐Rutamarin
Authors: Zhang Yi‐Nan , Zhang Shi‐Lei , Ma Lei , Zhang Yu , Shen Xu , Wang Wei , Hu Li‐Hong 
Published: October 2008

AbstractThe first enantioselective total synthesis of (+)‐rutamarin (1) is described. The synthetic route features the highly enantioselective construction of the stereogenic center via the Sharpless asymmetric dihydroxylation (99% ee), the facile assembly of quaternary carbon‐centered 3‐substituted side chain and high synthetic efficiency from readily available starting materials. Furthermore, the synthetic strategy could be readily adopted for the synthesis of (+)‐rutamarin analogues.
Rate Acceleration of Triethylamine‐Mediated Guanidine‐ Catalyzed Enantioselective Michael Reaction
Authors: Jiang Zhiyong , Ye Weiping , Yang Yuanyong , Tan Choon‐Hong 
Published: October 2008

AbstractA chiral bicyclic guanidine was found to be an excellent catalyst for enantioselective Michael reactions. It was observed that additives such as non‐chiral amines could accelerate the rate of reaction. When triethylamine (Et3N) was as used as the solvent, the reaction rate can be increased up to 1000 times without compromising the enantioselectivity. Michael acceptors such as 2‐cyclopenten‐1‐one 2 and N‐alkylmaleimides were investigated, with various commercially available Michael donors such as dialkyl malonates and benzoylactetates. Michael adducts were obtained in excellent enantiomeric excesses (up to 96%) and yields (up to 99%).
A Novel Bifunctional Sulfonamide Primary Amine‐Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins
Authors: Xue Fei , Zhang Shilei , Duan Wenhu , Wang Wei 
Published: October 2008

AbstractThe enantioselective conjugate addition of a variety of ketones to nitroolefins has been developed. The process is efficiently catalyzed by a novel bifunctional sulfonamide primary amine in good yields and with good levels of enantioselectivity.
Kapur–Toriello syndrome: Further delineation
Authors: Yokoyama Emiy , Martínez Angélica , González‐del Angel Ariadna 
Published: October 2008

AbstractWe report on a Mexican patient with mental retardation, cleft lip and palate, and facial anomalies characteristic of Kapur–Toriello syndrome described in 1991 by Kapur and Toriello in two sibs. The condition was considered a previously undescribed autosomal recessive disorder and only one patient has been reported since that time. The clinical manifestations observed in our patient confirm some characteristics as part of the entity. In view of rarity, it is necessary to describe additional cases. © 2008 Wiley‐Liss, Inc.
Robinow syndrome: Phenotypic variability in a family with a novel intragenic ROR2 mutation
Authors: Brunetti‐Pierri Nicola , del Gaudio Daniela , Peters Hartmut , Justino Henri , Ott Claus‐Eric , Mundlos Stefan , Bacino Carlos A. 
Published: October 2008

AbstractRobinow syndrome comprises dysmorphic facial features, short stature, brachymesomelia, segmental spine defects, and genital hypoplasia. The range of severity in this disorder is broad. We report on the clinical and molecular findings of two sib pairs from the same extended family with Robinow syndrome due to a novel intragenic ROR2 deletion involving exons 6 and 7 that could not be detected by sequencing. The affected individuals exhibited variability with respect to the cleft lip, cleft palate, and cardiac findings and for the presence in one of the patients of syringomyelia, which has not been previously reported in Robinow syndrome. © 2008 Wiley‐Liss, Inc.
A PCR‐based marker to simply identify Saimiri sciureus and S. boliviensis boliviensis
Authors: Osterholz Martin , Vermeer Jan , Walter Lutz , Roos Christian 
Published: October 2008

AbstractSquirrel monkeys, mainly Saimiri sciureus and S. boliviensis, are common in zoos and widely used in biomedical research. However, an exact species identification based on morphological characteristics is difficult. Hence, several molecular methods were proposed, but all of them are expensive and require extensive laboratory work. In contrast, we describe an Alu integration, which is present in S. boliviensis boliviensis and absent in S. sciureus. Among analyzed S. b. peruviensis specimens various presence/absence patterns of the integration were detected indicating that this study population might have originated from a natural hybrid zone. Based on the size of the Alu element (∼300 bp), the presence/absence pattern of the integration can easily be traced by PCR and followed by agarose gel electrophoresis. Am. J. Primatol. 70:1177–1180, 2008. © 2008 Wiley‐Liss, Inc.
Nomination time: CPR's 2008 law firm award
Authors: Bleemer Russ 
Published: October 2008

AbstractThe competition opens for CPR's second Law Firm Award for Excellence in ADR, with entries due this month. Also, details on next month's meeting in Houston; the CPR National Task Force on Diversity in ADR; the keynoter for January's 30th Anniversary CPR Annual Meeting, and much more.
Strategies for achieving an arbitration advantage require early analysis, pre‐hearing strategies, and awards scrutiny
Authors: Casey Kevin R. , Parker Marissa 
Published: October 2008

AbstractSetting a framework for resolving a dispute in arbitration is essential to make the process work. Kevin R. Casey and Marissa Parker, of Philadelphia, take a hard look at arbitration practice, and provide tips for your ADR game plan and for advising your client on getting to a successful resolution.
Do children with autism spectrum disorders show a shape bias in word learning?
Authors: Tek Saime , Jaffery Gul , Fein Deborah , Naigles Letitia R. 
Published: October 2008

AbstractMany children with autism spectrum disorders (ASD) acquire a sizeable lexicon. However, these children also seem to understand and/or store the meanings of words differently from typically developing children. One of the mechanisms that helps typically developing children learn novel words is the shape bias, in which the referent of a noun is mapped onto the shape of an object, rather than onto its color, texture, or size. We hypothesized that children with autistic disorder would show reduced or absent shape bias. Using the intermodal preferential looking paradigm , we compared the performance of young children with ASD and typically developing children (TYP), across four time points, in their use of shape bias. Neither group showed a shape bias at Visit 1, when half of the children in both groups produced fewer than 50 count nouns. Only the TYP group showed a shape bias at Visits 2, 3, and 4. According to the growth curve analyses, the rate of increase in the shape bias scores over time was significant for the TYP children. The fact that the TYP group showed a shape bias at 24 months of age, whereas children with ASD did not demonstrate a shape bias despite a sizeable vocabulary, supports a dissociation between vocabulary size and principles governing acquisition in ASD children from early in language development.
Production, partial purification and characterization of feruloyl esterase by Aspergillus awamori in submerged fermentation
Authors: Fazary Ahmed Eid , Ju Yi‐Hsu 
Published: October 2008

AbstractMicrobial feruloyl esterases acting on plant cell wall polymers represent key tools for the degradation of plant cell wall. In this paper, we describe in detail the microbial production, partial purification and characterization of feruloyl esterase from a culture medium of Aspergillus awamori strain IFO4033 obtained from a crude hemicellulose preparation of wheat straw, corncobs and wheat germ. Feruloyl esterase was extracted using centrifugation and dialysis, and then purified by ion exchange chromatography and microfiltration to homogeneity, which was checked by SDSPAGE and isoelectric focusing‐PAGE. Protein content and activity of the enzyme were measured in each step of extraction and purification. Biomass was determined by the dry weight method. pH and temperature optima of feruloyl esterase enzyme were also determined. The effects of culturing time, and carbon and nitrogen sources on enzyme production were systematically investigated. Finally, enzyme activities under different storage conditions were examined.
Gene delivery into hepatocytes with the preS/liposome/DNA system
Authors: Wang Zhijun , Yuan Zhenghong , Jin Li 
Published: October 2008

AbstractGene delivery into human hepatocytes remains a critical issue for the development of liver‐directed gene therapy. Gene delivery based on non‐viral vectors is an attractive approach relative to viral vectors. In this report, novel delivery system of preS/liposome/DNA virus‐like particle (VLP) was developed for gene transfection into hepatocytes in vivo and in vitro. Plasmid pCMVβ, expressing β‐galactosidase, was encapsulated with cationic liposome, and then the histidine‐tagged preS domain of hepatitis B virus was coated on the surface of liposome/DNA to form preS/liposome/ DNA VLP. Transfection efficiencies of preS/liposome/DNA, liposome/DNA, naked DNA and preS were analyzed using several different human cell lines. The highest transfection efficiency was found using preS/liposome/DNA VLP as the transfection reagent in human hepatocyte (HH) cell line. Results show that preS domain of hepatitis B virus coated on liposome/DNA can be used for highly efficient gene transfection into human hepatocytes. Moreover, the target characteristic of preS/liposome/DNA was analyzed in vivo. After preS/liposome/DNA VLP was injected into immunocompromised (Nude) mice via the tail vein, most of β‐galactosidase was expressed in the liver; however, no significant target expression was found with the injection of liposome/ DNA or naked DNA. Our results show that preS/liposome/DNA VLP can be used as a novel liver‐specific gene delivery system.
A guide to the integrated application of on‐line data mining tools for the inference of gene functions at the systems level
Authors: Meier Stuart , Gehring Chris 
Published: October 2008

AbstractGenes function in networks to achieve a common biological response. Thus, inferences into the biological role of individual genes can be gained by analyzing their association with other genes with more precisely defined functions. Here, we present a guide, using the well‐characterized Arabidopsis thaliana pathogenesis‐related protein 2 gene (PR‐2) as an example, to document how the sequential use of web‐based tools can be applied to integrate information from different databases and associate the function of an individual gene with a network of genes and additionally identify specific biological processes in which they collectively function. The analysis begins by performing a global expression correlation analysis to build a functionally associated gene network. The network is subsequently analyzed for Gene Ontology enrichment, stimuli and mutant‐specific transcriptional responses and enriched putative promoter regulatory elements that may be responsible for their correlated relationships. The results for the PR‐2 gene are entirely consistent with the published literature documenting the accuracy of this type of analysis. Furthermore, this type of analysis can also be performed on other organisms with the appropriate data available and will greatly assist in understanding individual gene functions in a systems context.
Reconstitution and Anchoring of Cytoskeleton inside Giant Unilamellar Vesicles
Authors: Merkle Dennis , Kahya Nicoletta , Schwille Petra 
Published: October 2008

AbstractAmong the requirements for all life forms is the ability to self‐replicate. In eukaryotic cellular systems, this division is achieved through cytokinesis, and is facilitated by the (re)arrangement and interaction of cytoskeletal proteins with lipids and other proteins localized to the plasma membrane. A fascinating challenge of modern synthetic biology is the bottom‐up reconstitution of such processes for the generation of an artificial cell. One crucial step towards this goal is the functional reconstitution of the protein‐anchoring machinery to facilitate cytokinesis into lipid vesicles. True to the ideal of a minimal cell‐like system, we here describe the formation of an actin‐based cytoskeleton within giant unilamellar vesicles (GUVs) made from porcine brain lipid extracts. We demonstrate that the actin filaments are localised and anchored to the interior walls of the GUVs through the spectrin/ankyrin proteins, and produce tightly packed actin bundles. These studies allow for the examination of cytoskeletal rearrangements within a cell‐like model membrane system and represent important first steps in reconstituting the minimal machinery required for the division of an artificial cell. In addition, the study of such minimal systems can shed light on protein functions that are commonly unobservable or hidden within the overwhelming complexity of cells.
Facile High‐Yield Synthesis of Polyaniline Nanosticks with Intrinsic Stability and Electrical Conductivity
Authors: Li Xin‐Gui , Li Ang , Huang Mei‐Rong 
Published: October 2008

AbstractChemical oxidative polymerization at 15 °C was used for the simple and productive synthesis of polyaniline (PAN) nanosticks. The effect of polymerization media on the yield, size, stability, and electrical conductivity of the PAN nanosticks was studied by changing the concentration and nature of the acid medium and oxidant and by introducing organic solvent. Molecular and supramolecular structure, size, and size distribution of the PAN nanosticks were characterized by UV/Vis and IR spectroscopy, X‐ray diffraction, laser particle‐size analysis, and transmission electron microscopy. Introduction of organic solvent is advantageous for enhancing the yield of PAN nanosticks but disadvantageous for formation of PAN nanosticks with small size and high conductivity. The concentration and nature of the acid medium have a major influence on the polymerization yield and conductivity of the nanosized PAN. The average diameter and length of PAN nanosticks produced with 2 M HNO3 and 0.5 M H2SO4 as acid media are about 40 and 300 nm, respectively. The PAN nanosticks obtained in an optimal medium (i.e., 2 M HNO3) exhibit the highest conductivity of 2.23 S cm−1 and the highest yield of 80.7 %. A mechanism of formation of nanosticks instead of nanoparticles is proposed. Nanocomposite films of the PAN nanosticks with poly(vinyl alcohol) show a low percolation threshold of 0.2 wt %, at which the film retains almost the same transparency and strength as pure poly(vinyl alcohol) but 262 000 times the conductivity of pure poly(vinyl alcohol) film. The present synthesis of PAN nanosticks requires no external stabilizer and provides a facile and direct route for fabrication of PAN nanosticks with high yield, controllable size, intrinsic self‐stability, strong redispersibility, high purity, and optimizable conductivity.
One‐Pot Catalytic Enantioselective Domino Nitro‐Michael/Michael Synthesis of Cyclopentanes with Four Stereocenters
Authors: Zhao Gui‐Ling , Ibrahem Ismail , Dziedzic Pawel , Sun Junliang , Bonneau Charlotte , Córdova Armando 
Published: October 2008

AbstractA highly enantioselective organocatalytic one‐pot synthesis of nitro‐, formyl‐, and ester‐functionalized cyclopentanes with four stereocenters is presented. The cyclopentanes were formed as a predominant diasteroisomer and isolated in high yields with 97–99 % ee.
Synthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological Functions
Authors: Kawasaki Akiko , Karasudani Yukie , Otsuka Yuji , Hasegawa Mizuho , Inohara Naohiro , Fujimoto Yukari , Fukase Koichi 
Published: October 2008

AbstractBacterial cell wall peptidoglycan (PGN) is a potent immunostimulator and immune adjuvant. The PGN of Gram‐negative bacteria and some Gram‐positive bacteria contain meso‐diaminopimelic acid (meso‐DAP), and we have recently shown that the intracellular protein Nod1 is a PGN receptor and recognizes DAP‐containing peptides. In this study, we achieved the synthesis of DAP‐containing PGN fragments, including the first chemical synthesis of tracheal cytotoxin (TCT), GlcNAc‐(β1–4)‐(anhydro)MurNAc‐L‐Ala‐γ‐D‐Glu‐meso‐DAP‐D‐Ala, and a repeating‐unit of DAP‐type PGN, GlcNAc‐(β1–4)‐MurNAc‐L‐Ala‐γ‐D‐Glu‐meso‐DAP‐D‐Ala. For the synthesis of PGN fragments, we first established a new synthetic method for an orthogonally protected meso‐DAP derivative, and then we constructed the glycopeptide structures. The ability of these fragments to stimulate human Nod1, as well as differences in Nod1 recognition of the variety of synthesized ligand structures were examined. The results showed that the substitution of the N terminus of iE‐DAP is necessary for stronger Nod1 recognition, but the structure of the substituent seems not to be strictly recognized. The importance of the carboxyl group at the 2‐position of DAP for human Nod1 stimulation was also shown.