bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Learning Method for Dynamic Process Modeling of Real Landslides Based on Fourier Neural Operator
Authors: Chen Yanglong , Ouyang Chaojun , Xu Qingsong , Yang Weibin 
Published: March 2024

AbstractThe conventional numerical solvers for partial differential equations encounter a formidable challenge, as their computational efficiency and accuracy are heavily contingent on grid size. Recently, machine learning (ML) has exhibited substantial promise in addressing partial differential equations. Nevertheless, substantial hurdles persist in practical applications. In this work, we endeavor to establish a deep learning framework founded on the Fourier neural operator (FNO) for resolving the intricacies of simulating real landslide dynamic processes. Our findings demonstrate that the current FNO approach adeptly replicates landslide dynamic processes and boasts exceptional computational efficiency. Additionally, it is noteworthy that this data‐driven ML methodology can seamlessly incorporate data from other experimental sources or numerical simulation techniques. Consequently, this work underscores the significant potential of utilizing ML methodologies to supplant conventional numerical simulation methods.
Variations of Inter‐Hemispheric Field‐Aligned Currents: Observations From Ground Geomagnetic Measurements
Authors: Archana R. K. , Arora Kusumita 
Published: March 2024

AbstractThe east–west component of the geomagnetic field (Y‐component) at the Trivandrum (TRD) station, an equatorial site, is used to investigate the characteristics of Inter‐Hemispheric Field‐Aligned Currents (IHFACs) in the Indian sector during solar cycles 21 and 22. The observations reveal an annual variation of IHFAC in the dawn/noon sector with positive/negative peaks around northern summer. Furthermore, it is noted that IHFAC amplitudes are modulated by solar activity, superimposed with seasonal effects, with consistently higher amplitudes during the northern summer months. The dusk‐time IHFAC also shows a pattern modulated by seasons and solar cycles, with negative peaks around northern summer only during the low solar active years. The seasonal pattern of IHFAC shows a similar trend from April to September, where dawn/noon IHFAC is south/north directed, and for the remaining months, both are northward directed. The dusk‐side IHFAC is mostly south‐directed irrespective of the season. Moreover, it is demonstrated that the seasonal pattern of dawn and noon‐time IHFAC amplitudes show a strong to moderate correlation with amplitudes of Sq asymmetries between two hemispheres, but dusk‐time IHFAC does not follow this trend. The IHFAC directions at TRD follow the Fukushima model for May to September during the dawn‐noon sector for 70%–95% of the days and less than 50% of the days for remaining months. The noon‐dusk sector shows Fukushima model‐type polarity for ∼60% of days in June–July and less than 50% for remaining months. The global analysis of IHFAC, using monthly averages of hourly values from eight observatories spanning Asia, Africa, and America, reveals spatial differences in amplitude and directions. The directions of noon‐time IHFAC in the Indian‐East Asian and East‐African sectors follow similar trends, and the amplitude variations of noon‐time IHFAC can be explained by DE‐3 tidal effects. The IHFAC from the South American and West African sectors show intense southward and northward currents compared to other sites, indicating the influence of the South Atlantic Anomaly (SAA).
Developing a General Daily Lake Evaporation Model and Demonstrating Its Application in the State of Texas
Authors: Zhao Bingjie , Huntington Justin , Pearson Christopher , Zhao Gang , Ott Thomas , Zhu John , Weinberg Andrew , Holman Kathleen D. , Zhang Shuai , Anderson Ron , Strickler Maxwell , Cotter Jerry , Fernando Nelun , Nowak Kenneth , Gao Huilin 
Published: March 2024

AbstractOpen water evaporation, which often consumes a large fraction of annual storage (especially in arid and semi‐arid regions), is a controlling variable for modern water resource management. Developing a daily reservoir evaporation data set is necessary for reservoir operations to consider the influence of evaporation in a timely manner. However, over the past few decades, the quantification of reservoir evaporation has primarily relied on monthly Class A pan evaporation observations, which might lead to largely biased estimations because they do not incorporate the effects of heat storage and fetch. In this study, we developed a general Daily Lake Evaporation Model (DLEM) based on Penman's equation combined with daily atmospheric reanalysis data sets, to improve the validity and frequency of reservoir evaporation monitoring. Compared with daily evaporation estimates from eddy covariance systems, the DLEM showed good quality and reliability, with R2 values ranging from 0.50 to 0.73 and RMSE values ranging from 1.13 to 1.97 mm day−1 in four different sites. By applying DLEM to all 188 major reservoirs in Texas, we generated a long‐term data set of (1 January 1981–31 December 2021) daily evaporation rates. The results reveal a clear geographic distribution and strong seasonality of evaporation throughout Texas, where the mean evaporation rate is highest during July, with 6.85 mm day−1. Trend analysis indicates that the annual average evaporation rate has significantly increased since 1981 at a rate of 0.076 mm day−1 decade−1. This study provides sufficient data support for water resource operations and management, and regional water planning.
Light People: Prof. Kei May Lau, newly elected US NAE member in Hong Kong, talks about future of photonics and women in science
Authors: Wan Yating , Guo Chenzi 
Published: March 2024

EditorialPhotonics technology remains a driving force in today’s scientific landscape, marked by continuous innovation and cross-disciplinary relevance. In an enlighting conversation with Light: Science & Applications, Prof. Kei May Lau, a pioneer in photonics research, shares her deep insights on the evolution of technologies of LEDs, lasers, challenges of hetero-epitaxy, and the future of micro-LEDs and quantum dot lasers. Recently honored as a member of the US National Academy of Engineering (NAE) for her significant contributions to photonics and electronics using III-V semiconductors on silicon, Prof. Lau stands out as the sole Hong Kong scholar inducted into the NAE this year, joining 114 new and 21 international members. In this exclusive Light People interview, Prof. Lau shares her journey as a pioneering woman in engineering, her commitment to mentorship and academia, and her perspective on advancing female representation in science. The summary provided is distilled from Prof. Lau’s thoughtful responses during the interview. For a deeper exploration of Prof. Lau’s experiences and advice, the full interview is available in the Supplementary material.
Efficacy of BioMin F and NovaMin toothpastes against streptococcus mutans: an in vitro study
Authors: Doura Alomari Haya , Alsayed Tolibah Yasser , Kouchaji Chaza 
Published: March 2024

Abstract
Objective
This in vitro study was accomplished to demonstrate the antibacterial efficacy of BioMin F and NovaMin toothpastes against the recently-isolated Streptococcus Mutans in comparison with a commonly used fluoride toothpaste.

Materials and methods
Dental plaque collection method was adopted to isolate streptococcus mutans in children with dental caries. Then an ideal Streptococcus Mutans colony was incubated in 20 Petri dishes that contained Mueller-Hinton medium. Each dish had 3 wells; one well for each toothpaste (BioMin F, NovMin, and Signal) to perform the agar diffusion test. After incubating for 24 hours, the inhabitation zone around each well of each Petri dish was noticed and measured. Statistical Analysis was achieved using a statistical package, SPSS Windows version 17, by applying Kruskal-Wallis with Mann–Whitney U test (α = 0.05).

Results
BioMin F showed the highest mean of inhibition zone diameter ($$\bar{x}$$

x

¯

= 2.67 mm) in compared with NovaMin and Signal ($$\bar{x}$$

x

¯

= 0.39 mm and $$\bar{x}$$

x

¯

= 2.19 mm; p < 0.001 in each pairwise comparison).

Conclusion
BioMin F toothpaste showed superior antibacterial effect against Streptococcus mutans to Signal and NovaMin toothpastes. Novamin showed the lowest antibacterial effect. This in vitro study suggests that BioMin F toothpaste shows encouraging potential to be recommended as a preventive measure to reduce the caries risk.
Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells
Authors: Preedy Marcus K. , White Michael R. H. , Tergaonkar Vinay 
Published: March 2024

AbstractCellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apoptosis and necroptosis. Following TNF stimulation, the fate of individual cells is governed by the balance of pro-survival and pro-apoptotic signalling pathways. To elucidate the molecular mechanisms driving heterogenous responses to TNF, quantifying TNF/TNFR1 signalling at the single-cell level is crucial. Fluorescence live-cell imaging techniques offer real-time, dynamic insights into molecular processes in single cells, allowing for detection of rapid and transient changes, as well as identification of subpopulations, that are likely to be missed with traditional endpoint assays. Whilst fluorescence live-cell imaging has been employed extensively to investigate TNF-induced inflammation and TNF-induced cell death, it has been underutilised in studying the role of TNF/TNFR1 signalling pathway crosstalk in guiding cell-fate decisions in single cells. Here, we outline the various opportunities for pathway crosstalk during TNF/TNFR1 signalling and how these interactions may govern heterogenous responses to TNF. We also advocate for the use of live-cell imaging techniques to elucidate the molecular processes driving cell-to-cell variability in single cells. Understanding and overcoming cellular heterogeneity in response to TNF and modulators of the TNF/TNFR1 signalling pathway could lead to the development of targeted therapies for various diseases associated with aberrant TNF/TNFR1 signalling, such as rheumatoid arthritis, metabolic syndrome, and cancer.
GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas
Authors: He Hua , Liang Lu , Jiang Shiyao , Liu Yueying , Huang Jingjing , Sun Xiaoyan , Li Yi , Jiang Yiqun , Cong Li 
Published: March 2024

AbstractTemozolomide (TMZ), a DNA alkylating agent, has become the primary treatment for glioma, the most common malignancy of the central nervous system. Although TMZ-containing regimens produce significant clinical response rates, some patients inevitably suffer from inferior treatment outcomes or disease relapse, likely because of poor chemosensitivity of glioma cells due to a robust DNA damage response (DDR). GINS2, a subunit of DNA helicase, contributes to maintaining genomic stability and is highly expressed in various cancers, promoting their development. Here, we report that GINS2 was upregulated in TMZ-treated glioma cells and co-localized with γH2AX, indicating its participation in TMZ-induced DDR. Furthermore, GINS2 regulated the malignant phenotype and TMZ sensitivity of glioma cells, mostly by promoting DNA damage repair by affecting the mRNA stability of early growth response factor 1 (EGR1), which in turn regulates the transcription of epithelial cell-transforming sequence 2 (ECT2). We constructed a GINS2–EGR1–ECT2 prognostic model, which accurately predicted patient survival. Further, we screened Palbociclib/BIX-02189 which dampens GINS2 expression and synergistically inhibits glioma cell proliferation with TMZ. These findings delineate a novel mechanism by which GINS2 regulates the TMZ sensitivity of glioma cells and propose a promising combination therapy to treat glioma.
Does renal denervation require cardiovascular outcome-driven data?
Authors: Haider Syedah Aleena , Wagener Max , Iqbal Talha , Shahzad Shirjeel , Del Sole Paolo Alberto , Leahy Niall , Murphy Darragh , Sharif Ruth , Ullah Ihsan , Sharif Faisal 
Published: March 2024

AbstractHypertension is a major driver of cardiovascular disease with a prevalence of 32–34% in adults worldwide. This poses a formidable unmet challenge for healthcare systems, highlighting the need for enhanced treatment strategies. Since 2017, eight major sham-controlled randomised controlled trials have examined the effectiveness and safety of renal denervation (RDN) as therapy for BP control. Although most trials demonstrated a reduction in systolic 24-hour/daytime ambulatory BP compared to control groups, open to discussion is whether major adverse cardiovascular events (MACE)-driven RDN trials are necessary or whether the proof of BP reduction as a surrogate for better cardiovascular outcomes is sufficient. We conducted an analysis of the statistical methods used in various trials to assess endpoint definitions and determine the necessity for MACE-driven outcome data. Such comprehensive analysis provides further evidence to confidently conclude that RDN significantly reduces blood pressure compared to sham controls. Importantly, this enables the interpolation of RDN trial endpoints with other studies that report on outcome data, such as pharmacological trials which demonstrate a significant reduction in MACE risk with a decrease in BP. Moreover, limitations associated with directly evaluating outcome data further support the use of BP as a surrogate endpoint. For example, conducting lengthier trials with larger numbers of participants to ensure robust statistical power presents a substantial challenge to evaluating outcome data. Thus, in light of the crucial need to tackle hypertension, there are notable advantages of considering BP as a surrogate for outcome data.
Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
Authors: de la Fuente Alerie Guzman , Dittmer Marie , Heesbeen Elise J. , de la Vega Gallardo Nira , White Jessica A. , Young Andrew , McColgan Tiree , Dashwood Amy , Mayne Katie , Cabeza-Fernández Sonia , Falconer John , Rodriguez-Baena Francisco Javier , McMurran Christopher E. , Inayatullah Mohammed , Rawji Khalil S. , Franklin Robin J. M. , Dooley James , Liston Adrian , Ingram Rebecca J. , Tiwari Vijay K. , Penalva Rosana , Dombrowski Yvonne , Fitzgerald Denise C. 
Published: March 2024

AbstractMyelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged as critical players in tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes is poorly understood. Here, we show that expansion of aged Treg does not rescue age-associated remyelination impairment due to an intrinsically diminished capacity of aged Treg to promote oligodendrocyte differentiation and myelination in male and female mice. This decline in regenerative Treg functions can be rescued by a young environment. We identified Melanoma Cell Adhesion Molecule 1 (MCAM1) and Integrin alpha 2 (ITGA2) as candidates of Treg-mediated oligodendrocyte differentiation that decrease with age. Our findings demonstrate that ageing limits the neuroregenerative capacity of Treg, likely limiting their remyelinating therapeutic potential in aged patients, and describe two mechanisms implicated in Treg-driven remyelination that may be targetable to overcome this limitation.
N6-methyladenosine modification is not a general trait of viral RNA genomes
Authors: Baquero-Pérez Belinda , Yonchev Ivaylo D. , Delgado-Tejedor Anna , Medina Rebeca , Puig-Torrents Mireia , Sudbery Ian , Begik Oguzhan , Wilson Stuart A. , Novoa Eva Maria , Díez Juana 
Published: March 2024

AbstractDespite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these findings are mostly based on m6A-Seq, an antibody-dependent technique with a high rate of false positives. Here, we address the presence of m6A in CHIKV and DENV RNAs. For this, we combine m6A-Seq and the antibody-independent SELECT and nanopore direct RNA sequencing techniques with functional, molecular, and mutagenesis studies. Following this comprehensive analysis, we find no evidence of m6A modification in CHIKV or DENV transcripts. Furthermore, depletion of key components of the host m6A machinery does not affect CHIKV or DENV infection. Moreover, CHIKV or DENV infection has no effect on the m6A machinery’s localization. Our results challenge the prevailing notion that m6A modification is a general feature of cytoplasmic RNA viruses and underscore the importance of validating RNA modifications with orthogonal approaches.
PCDHA9 as a candidate gene for amyotrophic lateral sclerosis
Authors: Zhong Jie , Wang Chaodong , Zhang Dan , Yao Xiaoli , Zhao Quanzhen , Huang Xusheng , Lin Feng , Xue Chun , Wang Yaqing , He Ruojie , Li Xu-Ying , Li Qibin , Wang Mingbang , Zhao Shaoli , Afridi Shabbir Khan , Zhou Wenhao , Wang Zhanjun , Xu Yanming , Xu Zhiheng 
Published: March 2024

AbstractAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic factors, we analyzed exome sequences in a large cohort of Chinese ALS patients and found a homozygous variant (p.L700P) in PCDHA9 in three unrelated patients. We generated Pcdhα9 mutant mice harboring either orthologous point mutation or deletion mutation. These mice develop progressive spinal motor loss, muscle atrophy, and structural/functional abnormalities of the neuromuscular junction, leading to paralysis and early lethality. TDP-43 pathology is detected in the spinal motor neurons of aged mutant mice. Mechanistically, we demonstrate that Pcdha9 mutation causes aberrant activation of FAK and PYK2 in aging spinal cord, and dramatically reduced NKA-α1 expression in motor neurons. Our single nucleus multi-omics analysis reveals disturbed signaling involved in cell adhesion, ion transport, synapse organization, and neuronal survival in aged mutant mice. Together, our results present PCDHA9 as a potential ALS gene and provide insights into its pathogenesis.
dCas13-mediated translational repression for accurate gene silencing in mammalian cells
Authors: Apostolopoulos Antonios , Kawamoto Naohiro , Chow Siu Yu A. , Tsuiji Hitomi , Ikeuchi Yoshiho , Shichino Yuichi , Iwasaki Shintaro 
Published: March 2024

AbstractCurrent gene silencing tools based on RNA interference (RNAi) or, more recently, clustered regularly interspaced short palindromic repeats (CRISPR)‒Cas13 systems have critical drawbacks, such as off-target effects (RNAi) or collateral mRNA cleavage (CRISPR‒Cas13). Thus, a more specific method of gene knockdown is needed. Here, we develop CRISPRδ, an approach for translational silencing, harnessing catalytically inactive Cas13 proteins (dCas13). Owing to its tight association with mRNA, dCas13 serves as a physical roadblock for scanning ribosomes during translation initiation and does not affect mRNA stability. Guide RNAs covering the start codon lead to the highest efficacy regardless of the translation initiation mechanism: cap-dependent, internal ribosome entry site (IRES)-dependent, or repeat-associated non-AUG (RAN) translation. Strikingly, genome-wide ribosome profiling reveals the ultrahigh gene silencing specificity of CRISPRδ. Moreover, the fusion of a translational repressor to dCas13 further improves the performance. Our method provides a framework for translational repression-based gene silencing in eukaryotes.
Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations
Authors: Adaikkan Chinnakkaruppan , Joseph Justin , Foustoukos Georgios , Wang Jun , Polygalov Denis , Boehringer Roman , Middleton Steven J. , Huang Arthur J. Y. , Tsai Li-Huei , McHugh Thomas J. 
Published: March 2024

AbstractThe precise temporal coordination of neural activity is crucial for brain function. In the hippocampus, this precision is reflected in the oscillatory rhythms observed in CA1. While it is known that a balance between excitatory and inhibitory activity is necessary to generate and maintain these oscillations, the differential contribution of feedforward and feedback inhibition remains ambiguous. Here we use conditional genetics to chronically silence CA1 pyramidal cell transmission, ablating the ability of these neurons to recruit feedback inhibition in the local circuit, while recording physiological activity in mice. We find that this intervention leads to local pathophysiological events, with ripple amplitude and intrinsic frequency becoming significantly larger and spatially triggered local population spikes locked to the trough of the theta oscillation appearing during movement. These phenotypes demonstrate that feedback inhibition is crucial in maintaining local sparsity of activation and reveal the key role of lateral inhibition in CA1 in shaping circuit function.
A multi-demand operating system underlying diverse cognitive tasks
Authors: Cai Weidong , Taghia Jalil , Menon Vinod 
Published: March 2024

AbstractThe existence of a multiple-demand cortical system with an adaptive, domain-general, role in cognition has been proposed, but the underlying dynamic mechanisms and their links to cognitive control abilities are poorly understood. Here we use a probabilistic generative Bayesian model of brain circuit dynamics to determine dynamic brain states across multiple cognitive domains, independent datasets, and participant groups, including task fMRI data from Human Connectome Project, Dual Mechanisms of Cognitive Control study and a neurodevelopment study. We discover a shared brain state across seven distinct cognitive tasks and found that the dynamics of this shared brain state predicted cognitive control abilities in each task. Our findings reveal the flexible engagement of dynamic brain processes across multiple cognitive domains and participant groups, and uncover the generative mechanisms underlying the functioning of a domain-general cognitive operating system. Our computational framework opens promising avenues for probing neurocognitive function and dysfunction.
Tuning of the flat band and its impact on superconductivity in Mo5Si3−xPx
Authors: Khasanov Rustem , Ruan Bin-Bin , Shi Yun-Qing , Chen Gen-Fu , Luetkens Hubertus , Ren Zhi-An , Guguchia Zurab 
Published: March 2024

AbstractThe superconductivity in systems containing dispersionless (flat) bands is seemingly paradoxical, as traditional Bardeen-Cooper-Schrieffer theory requires an infinite enhancement of the carrier masses. However, the combination of flat and steep (dispersive) bands within the multiple band scenario might boost superconducting responses, potentially explaining high-temperature superconductivity in cuprates and metal hydrides. Here, we report on the magnetic penetration depths, the upper critical field, and the specific heat measurements, together with the first-principles calculations for the Mo5Si3−xPx superconducting family. The band structure features a flat band that gradually approaches the Fermi level as a function of phosphorus doping x, reaching the Fermi level at x ≃ 1.3. This leads to an abrupt change in nearly all superconducting quantities. The superfluid density data placed on the ’Uemura plot‘ results in two separated branches, thus indicating that the emergence of a flat band enhances correlations between conducting electrons.