bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atrio-ventricular block after administration of lignocaine in patients treated with prenylamine
Authors: Grenadier E , Keidar S , Alpan G , Palant A 
Published: December 2008

Abstract
Four patients are described who exhibited prolonged Q-T intervals, multiple ventricular premature beats and ventricular tachycardia of the ‘torsade de pointes’ configuration whilst on treatment with prenylamine. In two of these patients, advanced atrio-ventricular block was established immediately following intravenous administration of lignocaine. The arrhythmia and the atrio-ventricular blocks were successfully controlled by ventricular pacing. The hazard of the simultaneous administration of these two drugs is stressed.
Warfarin-induced vasculitis: A dose-related phenomenon in susceptible individuals?
Authors: Howitt A J , Williams A J , Skinner Craig 
Published: December 2008

Summary
A case of warfarin-induced skin vasculitis in a 52-year-old female is reported. Bilateral breast involvement occurred but without progression to necrosis as in previously described cases. The pathogenesis is discussed and prescribing recommendations made in an attempt to avoid the complication in susceptible individuals.
Mixed connective tissue disease presenting as trigeminal neuropathy
Authors: Edmondstone W M , Price D K , Shepherd T H , Gooddy W W 
Published: December 2008

Summary
A 25-year-old man presented with an isolated trigeminal neuropathy 13 months before developing myalgia and lymphadenopathy. The onset of Raynaud’s phenomenon 2 months later suggested a diagnosis of mixed connective tissue disease (MCTD) and this was confirmed by high serum titres of speckled pattern antinuclear antibody, and antibody to ribonuclear protein.
A new weight-reducing drug with novel properties
Authors: Wheatley David 
Published: December 2008

Summary
Ciclazindol, a tetracyclic compound originally developed as an antidepressant, was compared to placebo in a double-blind trial involving 114 individuals who were at least 15% overweight. Following a one week control period patients were allocated to active or placebo groups by random distribution for a period of 4 weeks and this was followed by a final one-week observation period.
The mean weight loss of 47 patients who completed the trial on ciclazindol was 6·95 lbs (3·13 kg) and of 48 patients who completed the trial on placebo it was 5·0 lbs (2·25 kg) a difference which is statistically significant in favour of ciclazindol (P &lt; 0·05).
The trial demonstrated a marked placebo effect resulting in loss of weight in these patients, but the drug effect was significantly greater.
Thyrotoxic crisis following eclampsia and induction of labour
Authors: Menon V , McDougall W W , Leatherdale B A 
Published: December 2008

Summary
A patient was diagnosed to be thyrotoxic and commenced on medications, but it was not known that she was 13 weeks pregnant at the time. She failed to take the medications and presented at 25 weeks with eclampsia and thyrotoxic crisis. Her management is discussed.
Pathological stage IE lymphoma of the testis treated by local surgery alone
Authors: Kissin M W , Kark A E 
Published: December 2008

Summary
Testicular lymphoma is a rare tumour. Usually it is found in old men as part of a generalized lymphoma, and it carries a poor prognosis. We report a 30-year-old man with pathological stage IE lymphoma of the testis who has been successfully treated following staging laparotomy and splenectomy by radical orchidectomy alone. Localized testicular lymphoma is a small specific group with a good prognosis.
Painful brachial plexopathy: an unusual presentation of polyarteritis nodosa
Authors: Allan S G , Smith C C , Towla H M A , Downie A W , Clark J C 
Published: December 2008

Summary
An elderly man was admitted to hospital with an unusual painful bilateral brachial neuropathy, which progressed in spite of high dose corticosteroid therapy. Polyarteritis nodosa, characterized by widespread arteriolar involvement, was shown at post-mortem.
Renal failure as a suspected adverse reaction to benoxaprofen
Authors: Fine Wilfred , Tallis R C , Osman K M 
Published: December 2008

Summary
A 77-year-old woman suffering from osteoarthritis was treated with benoxaprofen. She developed diarrhoea, skin rash and renal failure.
Renal failure has not been reported before as an adverse reaction to benoxaprofen.
The case is discussed in the context of multisystem and immunological response to benoxaprofen.
Amoebic ulcer of the penis
Authors: Parkash Satya , Ananthakrishnan N , Ramakrishnan K , Topno Margaret , Aurora A L 
Published: December 2008

Summary
This is a report of a rare entity—an amoebic ulcer of the penis. The gross loss of glans and terminal urethra was repaired by a new technique using an island based anterolateral dartos flap.
Ligation of the external iliac artery for post-transplant nephrectomy bleeding
Authors: Brown M W , Bradley J A , Hamilton D N H 
Published: December 2008

Summary
Two patients who had transplant nephrectomy performed for rejection of a previously transplanted human cadaver allograft kidney subsequently developed complications due to a false aneurysm of the external iliac artery. Treatment was successfully carried out by ligation of the external iliac artery without any significant ischaemic problems in the corresponding lower limb.
Collagenous colitis: the clinical and morphological features
Authors: Colina F , Munoz-Yagüe M T , Solis-Herruzo J A , Vazquez G , Perez-Barrios A 
Published: December 2008

Summary
A woman aged 23 years is described who had watery diarrhoea and colicky abdominal pain with normal results on sigmoidoscopy and barium enema. Rectal biopsy showed a thick layer of collagen in the lamina propria below the free epithelial surface. This lesion extended throughout the length of the descending colon. The only change revealed by electron microscopy was an increase in the thickness of the sub-epithelial collagen layer which is normally present in the colon. The maturation of the fibroblasts was normal. The lesion in this patient may be considered as a small change from the normal situation. This lesion is typical of ‘collagenous colitis’ of which only three other cases have as yet been published.
An evaluation of the Bishop scoring system in relation to a method of induction of labour by intra-vaginal prostaglandin
Authors: Houghton D J 
Published: December 2008

Summary
This paper is a prospective study of the outcome of labour in 109 patients with favourable and unfavourable cervices in whom labour was induced by intravaginal prostaglandin, with supplementary syntocinon infusion where necessary. There were 61 primigravidae and 48 multigravidae. The rate of operative intervention was virtually no higher than in those labours of spontaneous onset. The length of labour varied inversely with the Bishop score of the cervix before induction, with a coefficient of correlation of -0·995 for primigravidae and of -0·929 for multigravidae. Bishop score was shown to be a poor indicator of the number of doses of prostaglandin needed for successful induction.
Acute exacerbation of upper airway obstruction in acromegaly
Authors: Rees P J , Hay J G , Webb J R 
Published: December 2008

Summary
A 71-year-old man with acromegaly is described. Investigations for dyspnoea and daytime somnolence showed upper airway obstruction but not sleep apnoea. An upper respiratory tract infection precipitated stridor which required urgent tracheostomy.
Reversible agranulocytosis in association with cimetidine and hepatic failure
Authors: Lewis D S , Beck E R 
Published: December 2008

Summary
A patient is described who developed agranulocytosis in the context of hepatic failure and cimetidine therapy. The close temporal relationship between discontinuation of the drug and granulopoietic recovery is considered to imply a role for cimetidine in the mechanism of the agranulocytosis.
Hypoglycaemia following removal of phaeochromocytoma: case report and review of the literature
Authors: Chambers Stephen , Donald Richard A , Espiner Eric A , Nicholls M Gary 
Published: December 2008

SummaryHypoglycaemia may complicate removal of a phaeochromocytoma, but its pathogenesis is not well understood. The sixth such case in the world literature is reported together with details of glucose tolerance testing and hormone levels before and after extirpation of an adrenal phaeochromocytoma. The mechanism of hypoglycaemia probably relates to a sudden decrease in circulating catecholamines which allows a rebound increase in insulin release and in peripheral glucose uptake. It is suggested that blood sugar levels should be monitored routinely after surgery for phaeochromocytoma.
Hyperthyroidism with periodic paralysis, acropachy, pre-tibial myxoedema, transient atrial fibrillation and myopathy
Authors: Guan R , Cheah J S 
Published: December 2008

Summary
A case of thyrotoxicosis presenting with periodic paralysis and later complicated by acropachy, pretibial myxoedema and transient atrial fibrillation is described. This association has not been reported previously. Possible aetiological links are discussed.
Treatment of the Budd-Chiari syndrome in polycythemia vera by repeated percutaneous transluminal angioplasty of a hepatic vein stenosis
Authors: Nishikawa M , Miyoshi S , Imai Y , Tarui S , Seki K , Minami Y , Kawata S , Nakamura H 
Published: December 2008

Summary
This report is of a 63-year-old man with polycythemia vera who developed the Budd-Chiari syndrome due to right hepatic vein stenosis. Diagnosis was made by laparoscopy and liver biopsy, and confirmed by hepatic venography. The patient was treated by percutaneous transluminal angioplasty, and recovered completely from ascites, leg oedema and venous stasis. No pulmonary embolism was observed. One month after angioplasty, a second laparoscopy and liver biopsy showed a marked improvement in hepatic congestion and haemorrhagic necrosis, thereby confirming the effectiveness of this technique in treating the Budd-Chiari syndrome. Further treatments with percutaneous transluminal angioplasty were required with a good clinical outcome.
Hypercalcaemia due to immobilization of a patient with Paget’s disease of bone
Authors: Nathan A W , Ludlam H A , Wilson D W , Dandona P 
Published: December 2008

Summary
A man with Paget’s disease of bone was admitted with a fractured neck of femur. On admission he was normocalcaemic, but with immobilization he rapidly became hypercalcaemic, despite a normal diet and no medication. The hypercalcaemia responded to calcitonin. Although hypercalcaemia is often quoted as complicating the immobilization of such patients, well documented uncomplicated cases have rarely been reported.
Uterine and ovarian leukaemic relapse during bone marrow remission in acute lymphoblastic leukaemia
Authors: Cantwell B , Cantwell D , Fennelly J J 
Published: December 2008

Summary
A patient with acute lymphoblastic leukaemia who developed ovarian and uterine leukaemic relapse while in bone marrow remission is described. Pelvic relapse is rarely reported during the clinical course of leukaemia in females. Pelvic ultrasonography, a non-invasive procedure, was of value as an aid in detecting pelvic relapse.
Electrical cardioversion for persistent atrial fibrillation after treatment of thyrotoxicosis
Authors: Emery P , Staffurth J S 
Published: December 2008

SummaryA review of 22 patients with atrial fibrillation after the treatment of thyrotoxicosis, who underwent elective electrical cardioversion, showed that only 45% were still in sinus rhythm at 2 years and 36% in the long term (mean 7·4 years). There were no significant differences in factors assessed between those persisting in sinus rhythm and in those who relapsed. A delay in the initial curative treatment of thyrotoxicosis may be a factor in influencing the outcome.
Effect of non-suckling on the pH of breast milk and its possible relationship with breast cancer
Authors: Malhotra S L 
Published: December 2008

SummaryThe pH of breast milk was determined in 10 lactating mothers after interrupting suckling from one of the breasts, alternately for 120 hr during the 1st, 12th and the 16th postpartum weeks. The milk from the unsuckled breasts had a slightly higher pH at all three times, being slightly alkaline as compared with the suckled breasts from which the milk was slightly acidic. There were differences also between the three diurnal feeds, the pH being higher in the last diurnal samples. If this temporary experimental stoppage of breast feeding is akin to decline of breast feeding, the changes in the pH of breast milk caused by it may provide clues to the mechanism of the long-suggested possible carcinogenic effect of a fall in the prevalence of breast feeding. An alkaline milieu surrounding epithelial cells causes hyperplasia, cell atypia and a marked increase in mitotic activity, changes which are a prelude to neoplasia. The causative relationship of late age at first birth does not find support in the thesis of the alkaline milieu in the aetiology of breast cancer presented here.
Primary peritonitis in children and adults
Authors: Armitage T G , Williamson R C 
Published: December 2008

Summary
Five cases of primary peritonitis are presented, with a sixth related case of pneumococcal peritonitis secondary to a ruptured ovarian cyst. The patients comprised 4 young girls who recovered, and 2 elderly females who died. Pneumococci were isolated in 3 patients; no organism was found in the other 3. One case of primary measles peritonitis has no apparent precedent.
Neurofibrosarcoma in Von Recklinghausen’s disease presenting with hypochromic anaemia
Authors: Bell J M , Ritch A E , Donovan I A 
Published: December 2008

Summary
A patient with Von Recklinghausen’s disease who developed a retroperitoneal neurofibrosarcoma is described. The presenting clinical picture was one of hypochromic anaemia with a large mass palpable in the left hypochondrium. At operation the tumour was found to be invading the small intestine with resultant blood loss. The patient had presented 21 years before with unexplained severe iron deficiency anaemia.
Neurotensin-secreting carcinoma of the bronchus
Authors: Wood J R , Wood S M , Lee Y C , Bloom S R 
Published: December 2008

SummaryNeurotensin, a neuroendocrine peptide present in gut and brain has previously been found in pancreatic tumours secreting several other peptides. We report here the first case of a patient with a neurotensin-secreting adenocarcinoma of the bronchus.
Achalasia-like disturbance of oesophageal motility following truncal vagotomy and antrectomy
Authors: Greatorex R A , Thorpe J A C 
Published: December 2008

Summary
This report describes a patient who developed radiological and manometric evidence of an achalasia-like disturbance of oesophageal motility following transabdominal truncal vagotomy and antrectomy. The patient presented with severe dysphagia which spontaneously resolved after 8 weeks. Subsequent barium swallow and oesophageal manometry demonstrated a return to normal function.
Sarcoid-like lymphadenopathy in malignant teratoma
Authors: O’Connell M , Powell S , Horwich A 
Published: December 2008

Summary
The reported association between sarcoidosis and malignancy has relevance both to the diagnosis of the cause of lymphadenopathy and possibly also to the prognosis of the malignant disease. A case is reported in which mediastinal lymphadenopathy due to non-caseating epithelioid granulomata caused diagnostic difficulty in the staging investigation of a patient with malignant testicular teratoma.
Ranitidine compared with cimetidine in the short-term healing of duodenal ulcer
Authors: Lee F I , Fielding J D , Costello F T 
Published: December 2008

SummaryThe efficacy of ranitidine (150 mg twice daily) and cimetidine (200 mg three times daily and 400 mg at night) in the short-term healing of duodenal ulcer has been assessed in a randomized controlled trial involving 106 patients. There were 3 drop-outs. Forty-two out of 53 patients (79%) treated with ranitidine had healed ulcers at 4 weeks compared with 37 out of 50 treated with cimetidine (74%). This difference is not significant. At 8 weeks the healing rate for ranitidine (98%) was significantly greater than that for cimetidine (86%) (P less than 0.05). There was no significant difference in healing rates between men and women and between smokers and non-smokers. Side effects were not a problem with either drug. There were no differences of clinical significance between laboratory values in the two treatment groups, although a minor increase in mean creatinine levels occurred in the cimetidine-treated group.
Endomyocardial fibrosis in Africa
Authors: Falase A O 
Published: December 2008

Summary
Endomyocardial fibrosis (EMF) is a disease of the rain-forest belt in Africa. There is general agreement as to its pathology in the acute phase, but this is difficult to diagnose clinically. The aetiology is still unknown although there are reports which suggest that eosinophilic endomyocardial disease may be the cause. Further studies are needed to define EMF in its acute stage and find out how chronic EMF evolves. A longitudinal study on young people with eosinophilia and a comparative study of two villages, one in an endemic zone and the other in a zone where EMF is uncommon, will also be helpful in identifying its cause. The most promising form of treatment at present is surgical.
A comparison of the clinical and cardiological features of endomyocardial disease in temperate and tropical regions
Authors: Davies J , Spry C J F , Vijayaraghavan G , De Souza J A 
Published: December 2008

Summary
This study was designed to compare the clinical and cardiological features of endomyocardial disease in temperate and tropical regions. Eleven patients were studied in the U.K., 47 in India and 8 in Brazil. The patients in the U.K. were older, with a male predominance, and they had a systemic illness: the hypereosinophilic syndrome. Half of these patients presented in the early necrotic stage of the disease, and all had biventricular involvement. On the other hand, patients in the tropical countries were younger, with an equal sex incidence, and were from poor, malnourished communities with heavy parasite loads, especially filariasis in India. None presented in the early necrotic stage of the disease and a quarter had isolated right or left ventricular disease.
In order to account for these differences between patients in temperate and tropical regions with endomyocardial disease, it was proposed that the nature of the underlying disease and the rate at which endomyocardial lesions develop, determine the clinical features of this disorder. In temperate climates eosinophil granule toxins may produce a rapidly progressive form of the disease in patients with the hypereosinophilic syndrome, whereas the disease may take longer to develop in patients in tropical climates, who have a less marked eosinophilia due to parasitic infections.
Ventricular fibrillation and initial plasma potassium in acute myocardial infarction
Authors: Thomas Roderic D 
Published: December 2008

SummaryIn a retrospective review of patients admitted to a coronary care unit, 809 patients had a definite myocardial infarction and plasma potassium was measured within 48 hr. The mean (+/- s.d.) plasma potassium was 4.04 (+/- 0.56) mmol/litre. A potassium concentration of less than 4.0 mmol/litre was found in 383 patients, of whom 14 had ventricular fibrillation. A potassium concentration of 4.0 mmol/litre or greater was found in 426 patients, of whom 3 had ventricular fibrillation, a difference significant at the 0.4% level (chi 2 test). Preceding diuretic therapy did not appear to be relevant and there appeared to be no other difference between the two groups. The maintenance of a high-normal plasma potassium, or the prevention of its reduction, in patients with an acute myocardial infarction may be important.
Splenic abscess: successful non-surgical therapy
Authors: Jolobe O M P , Melnick S C 
Published: December 2008

Summary
A 57-year-old man with splenic abscess, demonstrated by isotope scanning, ultrasonography and computerized axial tomography (CAT scan) during the course of a septicaemic illness resulting from culture-positive bacterial endocarditis, was successfully treated with antibiotics alone, resolution of the abscess being confirmed by 2 further scans. This is the second case report of successful conservative treatment of splenic abscess.
Renal elimination of amiodarone and its desethyl metabolite
Authors: Harris L , Hind C R K , McKenna W J , Savage C , Krikler S J , Storey G C A , Holt D W 
Published: December 2008

Summary
Two patients in chronic renal failure receiving amiodarone for the treatment of refractory arrhythmias were commenced on dialysis, in one case, intermittent peritoneal dialysis, in the other, haemodialysis. Plasma concentrations of amiodarone and its desethyl metabolite were consistent with the dose received, whilst neither compound was recovered in the dialysate. In these patients and in 10 additional patients with normal renal function taking amiodarone, only negligible amounts of either compound were detected in urine. These findings suggest that amiodarone may be a suitable antiarrhythmic agent for use in patients with chronic renal failure.
The antemortem diagnosis of pyogenic liver abscess due to perforation of the gut by a foreign body
Authors: Shaw Pamela J , Freeman J G 
Published: December 2008

Summary
Perforation of the gastrointestinal tract by ingested foreign bodies is rare; the diagnosis of pyogenic liver abscess resulting from such perforations is usually made at post-mortem. We present a case of perforation of the gut, due to an ingested dental plate, with a resultant pyogenic liver abscess, which presented as a pyrexia of unknown origin.
Depression after stroke: a hospital treatment survey
Authors: Lim M L , Ebrahim S B J 
Published: December 2008

Summary
Treatment with anti-depressant drugs of 61 inpatients admitted on account of stroke was studied. Eighteen patients (30%) were being so treated. Only 5 patients (17%) with dysphasia were being treated with anti-depressant drugs compared with 13 patients (41%) without dysphasia (P less than 0.05). Dosage levels used were generally low and only one patient had been referred for a psychiatric opinion. We suggest that the difference in anti-depressant usage is because dysphasic patients are more difficult to assess and therefore less likely to have depressive symptoms recognized and treatment given. We also think that psychiatric referral should be used more often for assessment of stroke patients and for advice about treatment.
Chlorpromazine, placebo and droperidol in the treatment of nausea and vomiting associated with cisplatin therapy
Authors: Stuart-Harris R , Buckman R , Starke I , Wiltshaw Eve 
Published: December 2008

Summary
The use of cisplatin may be associated with severe nausea and vomiting. Two separate, randomized, double-blind trials, comparing the anti-emetic effect of chlorpromazine with placebo and chlorpromazine with droperidol, were conducted in patients receiving cisplatin for ovarian cancer. Chlorpromazine was statistically superior to placebo in the control of nausea and vomiting in those patients treated with chlorpromazine had significantly less nausea than with droperidol, but there were no other significant differences between chlorpromazine and droperidol. Toxicities of chlorpromazine and droperidol were similar. Chlorpromazine shows useful activity against cisplatin nausea and vomiting.
Guillain-Barré syndrome associated with tuberculosis
Authors: Vyravanathan S , Senanayake N 
Published: December 2008

Summary
Two cases of Guillain-Barré syndrome occurring in association with chronic pulmonary tuberculosis are reported. A cell-mediated, delayed hypersensitivity reaction to, or invasion of the nerve roots by tubercle bacilli would seem to be the likely explanation of the neuropathy.