bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using an intersectionality-based approach to evaluate mental health services use among gay, bisexual and other men who have sex with men in Montreal, Toronto and Vancouver
Authors: Marbaniang Ivan , Moodie Erica E. M. , Latimer Eric , Skakoon-Sparling Shayna , Hart Trevor A. , Grace Daniel , Moore David M. , Lachowsky Nathan J. , Jollimore Jody , Lambert Gilles , Zhang Terri , Dvorakova Milada , Cox Joseph ,   Engage Team Members
Published: March 2024

AbstractAimsTo cope with homonegativity-generated stress, gay, bisexual and other men who have sex with men (GBM) use more mental health services (MHS) compared with heterosexual men. Most previous research on MHS among GBM uses data from largely white HIV-negative samples. Using an intersectionality-based approach, we evaluated the concomitant impact of racialization and HIV stigma on MHS use among GBM, through the mediating role of perceived discrimination (PD).MethodsWe used baseline data from 2371 GBM enrolled in the Engage cohort study, collected between 2017 and 2019, in Montreal, Toronto and Vancouver, using respondent-driven sampling. The exposure was GBM groups:Group 1(n= 1376): white HIV-negative;Group 2(n= 327): white living with HIV;Group 3(n= 577): racialized as non-white HIV-negative;Group 4(n= 91): racialized as non-white living with HIV. The mediator was interpersonal PD scores measured using the Everyday Discrimination Scale (5-item version). The outcome was MHS use (yes/no) in the prior 6 months. We fit a three-way decomposition of causal mediation effects utilizing the imputation method for natural effect models. We obtained odds ratios (ORs) for pure direct effect (PDE, unmediated effect), pure indirect effect (PIE, mediated effect), mediated interaction effect (MIE, effect due to interaction between the exposure and mediator) and total effect (TE, overall effect). Analyses controlled for age, chronic mental health condition, Canadian citizenship, being cisgender and city of enrolment.ResultsMean PD scores were highest for racialized HIV-negative GBM (10.3, SD: 5.0) and lowest for white HIV-negative GBM (8.4, SD: 3.9). MHS use was highest in white GBM living with HIV (GBMHIV) (40.4%) and lowest in racialized HIV-negative GBM (26.9%). Compared with white HIV-negative GBM, white GBMHIV had higher TE (OR: 1.71; 95% CI: 1.27, 2.29) and PDE (OR: 1.68; 95% CI: 1.27, 2.24), and racialized HIV-negative GBM had higher PIE (OR: 1.09; 95% CI: 1.02, 1.17). Effects for racialized GBMHIV did not significantly differ from those of white HIV-negative GBM. MIEs across all groups were comparable.ConclusionsHigher MHS use was observed among white GBMHIV compared with white HIV-negative GBM. PD positively mediated MHS use only among racialized HIV-negative GBM. MHS may need to take into account the intersecting impact of homonegativity, racism and HIV stigma on the mental health of GBM.
Vocabulary acquisition in the language classroom: what it is, how it works, which strategies and approaches are suitable for Latin instruction
Authors: Aguilar García María Luisa 
Published: March 2024

AbstractThis paper aims to guide the training of all Latin instructors and learners who want to optimise the process of acquiring the language by applying the results of research carried out in the field of Second Language Acquisition (SLA), specifically here those related to the acquisition of vocabulary. Consequently, some theoretical considerations on the psycholinguistic operations that govern vocabulary learning are first offered, in order to build a better understanding of language acquisition and to make instructors and learners more knowledgeable about the vocabulary learning process, from the noticing of an unknown word and its integration into the subject's competence to the expansion and development of knowledge about the acquired words. The theoretical aspects of vocabulary learning will be illustrated at all times with practical examples taken from methods and books for learning Latin, as well as, in the fourth section, with a wide catalogue of practical advice – must-do items for the class – that can be easily implemented by Latin instructors.
A Theory of Maximum Entropy Production and Its Application to Microwave Remote Sensing—Simultaneous Retrieval of Soil Moisture and Vegetation Water Content
Authors: Wang J. , Cho K. , Negron‐Juarez R. I. , Colliander A. , Caravasi E. C. , Revilla N. S. 
Published: March 2024

AbstractA theory of maximum entropy production (MEP) for electromagnetic wave propagation in dielectric materials is proposed and applied to simultaneously retrieving soil moisture (SM) and vegetation water content (VWC) from L‐band microwave brightness temperature (TB). One representation of the MEP principle states that a non‐equilibrium system corresponds to such a configuration of energy fluxes that minimizes a dissipation function under the constraint of energy conservation. The dissipation function for radiative transfer is formulated as an analogy of that for heat transfer. A new physical parameter, radiative inertia as an analogy of thermal inertia, is introduced to characterize radiative attenuation in dielectric media. The radiative inertia is parameterized in terms of the penetration depth of electromagnetic waves as a function of the complex dielectric constant. The MEP based retrieval algorithm predicts SM and VWC by minimizing the dissipation function under the constraint of the conservation of radiative energy. The retrievals of SM and VWC based on the MEP theory were validated against field observations in tropical and temperate forested regions of the Amazon and North America. The proof‐of‐concept analysis demonstrates the capability of the MEP algorithm for simultaneous retrievals of SM and VWC even for dense canopy (e.g., VWC > 5 kg m−2). The MEP method is a new theoretical framework for developing innovative remote sensing algorithms of the Earth system not limited to microwave observations.
Variability of Eddy Kinetic Energy in the Eurasian Basin of the Arctic Ocean Inferred From a Model Simulation at 1‐km Resolution
Authors: Müller Vasco , Wang Qiang , Koldunov Nikolay , Danilov Sergey , Sidorenko Dmitry , Jung Thomas 
Published: March 2024

AbstractMesoscale eddies play an important role in driving the dynamics of the Arctic Ocean. Understanding their behavior is crucial for comprehending the ongoing changes in the region. In this study, by using a novel decade‐long simulation at 1 km resolution with the unstructured‐mesh Finite volumE Sea ice‐Ocean Model, we evaluate the spatial and temporal variability of eddy kinetic energy in the Eurasian Basin. We find that monthly, annual, and interannual variability of EKE near the surface is predominantly influenced by changes in sea ice cover, while the eddy activity at deeper depth, being shielded from the surface by ocean stratification, is more strongly influenced by local baroclinic energy conversion. Moreover, our research demonstrates that eddies in the Eurasian Basin can transport ocean heat from the Atlantic Water layer toward sea ice and cause local basal melting in the order of about 20 cm per month even in wintertime. Our study suggests that eddy activity in the Arctic Ocean will strengthen along with future sea ice decline, and that the impact of ocean heat of the Atlantic Water layer on sea ice retreat may become prominent.
Tectonic Evolution of the Eastern Southern Alps (Italy): A Reappraisal From New Structural Data and Geochronological Constraints
Authors: Curzi Manuel , Viola Giulio , Zuccari Costantino , Aldega Luca , Billi Andrea , van der Lelij Roelant , Kylander‐Clark Andrew , Vignaroli Gianluca 
Published: March 2024

AbstractThe Eastern Southern Alps fold‐and‐thrust belt (ESA) is part of the seismically active S‐verging retro‐wedge of the European Alps. Its temporal tectonic evolution during continental shortening has so far been constrained by few and low‐resolution indirect time constraints. Aiming at better elucidating the ESA spatiotemporal evolution, we gathered new structural and geochronological data from two regional thrust systems: the innermost south verging Valsugana Thrust (VT) and the more external Belluno Thrust System (BTS). Field work allowed us to constrain the geometry and kinematics of those thrusts and related folds and informed our sampling strategy to carry out fault gouge K‐Ar and tectonic carbonate U‐Pb dating from representative samples structurally associated with the VT and BTS. Our results suggest that the VT was active already in the Late Cretaceous (between ∼78 and 76 Ma) in response to far‐field stresses, with repeated reactivation continuing to the Late Miocene (∼6 Ma). The BTS recorded two distinct deformation events during the Oligocene (∼30 Ma) and at the Oligocene‐Miocene boundary (∼23 Ma). The VT was active for ∼72 Myr and partly acted during out‐of‐sequence thrusting. Based on regional correlations, we propose that the ESA share a similar spatiotemporal deformation history with the central Southern Alps farther to the west. We suggest a conceptual regional tectonic model wherein multiple, broadly coeval deformation events occurred in the entire Southern Alps during their long‐lived orogenic deformation in response to generally continuous NW‐SE shortening.
Rebuilding the microenvironment of primary tumors in humans: a focus on stroma
Authors: Mun Siwon , Lee Hyun Jin , Kim Pilnam 
Published: March 2024

AbstractConventional tumor models have critical shortcomings in that they lack the complexity of the human stroma. The heterogeneous stroma is a central compartment of the tumor microenvironment (TME) that must be addressed in cancer research and precision medicine. To fully model the human tumor stroma, the deconstruction and reconstruction of tumor tissues have been suggested as new approaches for in vitro tumor modeling. In this review, we summarize the heterogeneity of tumor-associated stromal cells and general deconstruction approaches used to isolate patient-specific stromal cells from tumor tissue; we also address the effect of the deconstruction procedure on the characteristics of primary cells. Finally, perspectives on the future of reconstructed tumor models are discussed, with an emphasis on the essential prerequisites for developing authentic humanized tumor models.
The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress
Authors: Jeong Dae Jin , Um Jee-Hyun , Kim Young Yeon , Shin Dong Jin , Im Sangwoo , Lee Kang-Min , Lee Yun-Hee , Lim Dae-sik , Kim Donghoon , Yun Jeanho 
Published: March 2024

AbstractMitophagy induction upon mitochondrial stress is critical for maintaining mitochondrial homeostasis and cellular function. Here, we found that Mst1/2 (Stk3/4), key regulators of the Hippo pathway, are required for the induction of mitophagy under various mitochondrial stress conditions. Knockdown of Mst1/2 or pharmacological inhibition by XMU-MP-1 treatment led to impaired mitophagy induction upon CCCP and DFP treatment. Mechanistically, Mst1/2 induces mitophagy independently of the PINK1-Parkin pathway and the canonical Hippo pathway. Moreover, our results suggest the essential involvement of BNIP3 in Mst1/2-mediated mitophagy induction upon mitochondrial stress. Notably, Mst1/2 knockdown diminishes mitophagy induction, exacerbates mitochondrial dysfunction, and reduces cellular survival upon neurotoxic stress in both SH-SY5Y cells and Drosophila models. Conversely, Mst1 and Mst2 expression enhances mitophagy induction and cell survival. In addition, AAV-mediated Mst1 expression reduced the loss of TH-positive neurons, ameliorated behavioral deficits, and improved mitochondrial function in an MPTP-induced Parkinson’s disease mouse model. Our findings reveal the Mst1/2-BNIP3 regulatory axis as a novel mediator of mitophagy induction under conditions of mitochondrial stress and suggest that Mst1/2 play a pivotal role in maintaining mitochondrial function and neuronal viability in response to neurotoxic treatment.
Teclistamab in relapsed refractory multiple myeloma: multi-institutional real-world study
Authors: Mohan Meera , Monge Jorge , Shah Nishi , Luan Danny , Forsberg Mark , Bhatlapenumarthi Vineel , Balev Metodi , Patwari Anannya , Cheruvalath Heloise , Bhutani Divaya , Thanendrarajan Sharmilan , Dhakal Binod , Zangari Maurizio , Al-Hadidi Samer , Cooper Dennis , Lentzsch Suzanne , van Rhee Frits , D’Souza Anita , Szabo Aniko , Schinke Carolina , Chakraborty Rajshekhar 
Published: March 2024

AbstractThe objective of our study was to report real-world data on the safety and efficacy of standard-of-care teclistamab in patients with relapsed/refractory multiple myeloma (MM). This is a multi-institutional retrospective cohort study and included all consecutive patients that received at least one dose of teclistamab up until August 2023. One hundred and ten patients were included, of whom, 86% had triple-class refractory disease, 76% penta-refractory disease, and 35% had prior exposure to B-cell maturation antigen (BCMA)-targeting therapies. The overall response rate (ORR) in our cohort was 62%, with a ≥ very good partial remission (VGPR) rate of 51%. The ORR in patients with and without prior BCMA-targeted therapies was 54% vs 67%, respectively (p = 0.23). At a median follow-up of 3.5 months (range, 0.39–10.92), the estimated 3 month and 6 month progression free survival (PFS) was 57% (95% CI, 48%, 68%) and 52% (95% CI, 42%, 64%) respectively. The incidence of cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) was 56% and 11% respectively, with grade ≥3 CRS and ICANS noted in 3.5% and 4.6% of patients respectively. 78 unique infections were diagnosed in 44 patients, with the incidence of all-grade and grade ≥3 infections being 40% vs 26% respectively. Primary prophylaxis with intravenous immunoglobulin (IVIG) was associated with a significantly lower infection risk on multivariate analysis (Hazard ratio [HR] 0.33; 95% CI 0.17, 0.64; p = 0.001).
Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT
Authors: Sureda Anna , Carpenter Paul A. , Bacigalupo Andrea , Bhatt Vijaya Raj , de la Fuente Josu , Ho Aloysius , Kean Leslie , Lee Jong Wook , Sánchez-Ortega Isabel , Savani Bipin N. , Schetelig Johannes , Stadtmauer Edward A. , Takahashi Yoshiyuki , Atsuta Yoshiko , Koreth John , Kröger Nicolaus , Ljungman Per , Okamoto Shinichiro , Popat Uday , Soiffer Robert , Stefanski Heather E. , Kharfan-Dabaja Mohamed A. 
Published: March 2024

AbstractDespite emergence of novel therapies to treat hematologic malignancies, allogeneic hematopoietic cell transplantation (allo-HCT) remains an essential treatment modality capable of curing these diseases. Allo-HCT has been also shown to be curative in benign hematologic disorders such as aplastic anemia, sickle cell disease, and thalassemia, among others. Recently, the American Society for Transplantation and Cellular Therapy (ASTCT) published standardized definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism. To attempt broader international consensus, a panel of adult and pediatric physician transplant experts was assembled from European Society for Blood and Marrow Transplantation (EBMT), ASTCT, the Center for International Blood and Marrow Transplant Research (CIBMTR), and Asia-Pacific Blood and Marrow Transplantation (APBMT). Consensus was defined as ≥70% of voting members strongly agreeing or somewhat agreeing with a definition. With few exceptions, there was a consensus to endorse the prior ASTCT definitions. Importantly, we revised existing EBMT and CIBMTR data collection forms to align with these harmonized definitions that will facilitate research and international collaboration among transplant researchers and across transplant registries.
Environmental sustainability: the attitudes and experiences of UK students in the oral health care profession
Authors: Durnall Olivia , Martin Nicolas , Mulligan Steven , Dixon Jonathan 
Published: March 2024

AbstractObjective This study aims to provide insight into the attitudes and perspectives of undergraduate dental students from UK dental schools regarding environmental sustainability in dentistry (ESD) and the manner and extent in which ESD is included in the current undergraduate oral health care curricula.Methods This study is a multi-centre, nationally representive study involving a cross-sectional online survey of undergraduate Bachelor of Dental Surgery and dental hygiene and therapy students in UK-based dental schools. Data analysis was conducted through descriptive statistics and thematic analysis.Results In total, 263 students from 13 UK schools completed the survey, resulting in a national school response rate of 68.4%. Key findings are: 97.3% of students believe that the dental profession should be more actively engaged in environmental sustainability but students currently have very little exposure to ESD at an undergraduate level; and 76.8% of students expressed that they are concerned about the impact that oral health care provision has on the environment, but only 23% of students have independently researched ESD.Conclusions Students identify that oral health care professionals should become more engaged in efforts to mitigate the negative impacts from our activities on the environment, principally via education at all levels. The data from this study provide insight into the current level of awareness and concerns for the environmental impacts of oral health care provision, and are a powerful driver for the inclusion of ESD into the undergraduate curriculum in UK based dental schools.
Development of NK cell-based cancer immunotherapies through receptor engineering
Authors: Page Audrey , Chuvin Nicolas , Valladeau-Guilemond Jenny , Depil Stéphane 
Published: March 2024

AbstractNatural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early clinical trials have shown promising outcomes, alongside satisfactory product efficacy and safety. Recent developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic capacities. This review focuses on surface receptor engineering in NK cell therapy and discusses its impact, challenges, and future directions.Most approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen restriction. This approach has increased the precision and potency of NK-mediated recognition and elimination of cancer cells. In addition, engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes, which broadens the range of target peptides. Indirect tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and signaling. Indeed, engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies, thereby increasing their antibody-dependent cellular cytotoxicity. The ability of NK cell receptor engineering to promote the expansion, persistence, and infiltration of transferred cells in the tumor microenvironment has also been explored. Receptor-based strategies for sustained NK cell functionality within the tumor environment have also been discussed, and these strategies providing perspectives to counteract tumor-induced immunosuppression.Overall, receptor engineering has led to significant advances in NK cell-based cancer immunotherapies. As technical challenges are addressed, these innovative treatments will likely reshape cancer immunotherapy.
Himplant® subcutaneous penile implant improves penile appearance and erectile dysfunction after radical prostatectomy: a case series
Authors: Valenzuela Robert J. , Elist James J. , Moon Daniel , Cvijanovic Luka , Wilson Steven K. 
Published: March 2024

AbstractErectile dysfunction is a major postoperative complication following radical prostatectomy. Various treatments for post- radical prostatectomy erectile dysfunction including nonsurgical phosphodiesterase-5 inhibitors, intraurethral alprostadil, intracavernosal injections and penile implant prosthesis, often yield suboptimal results. In this prospective single-center case series, we examine the efficacy and outcomes of Himplant®, a subcutaneous silicone penile implant, placement in four patients with post-radical prostatectomy erectile dysfunction who experienced limited benefits with phosphodiesterase-5 inhibitors. Patient data including demographics, prostate cancer diagnoses, erectile dysfunction characteristics, previous treatments, and outcomes were collected. Himplant® placement was performed in a standardized manner through a high scrotal incision in all cases. Follow-up evaluations were conducted to assess the effectiveness of the procedure and any associated complications. Patients were contacted and asked 15 questions regarding satisfaction and erectile function with the responses recorded. This study presents findings of high patient satisfaction, increases in flaccid penile length and girth, no incidence of adverse events, and improved erectile function following Himplant® placement post-radical prostatectomy. Accordingly, we suggest Himplant® placement in patients who are frustrated by their penile appearance and suffering from erectile dysfunction after radical prostatectomy. Further multicenter studies are warranted to validate these findings and assess long-term outcomes and patient-reported satisfaction.
Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound
Authors: Han Mertcan , Yildiz Erdost , Bozuyuk Ugur , Aydin Asli , Yu Yan , Bhargava Aarushi , Karaz Selcan , Sitti Metin 
Published: March 2024

AbstractElectrical stimulation is a fundamental tool in studying neural circuits, treating neurological diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric particle systems have emerged as non-genetic and wireless alternatives for electrode-based tethered stimulation systems. However, achieving cell-specific and high-frequency piezoelectric neural stimulation remains challenging due to high-intensity thresholds, non-specific diffusion, and internalization of particles. Here, we develop cell-sized 20 μm-diameter silica-based piezoelectric magnetic Janus microparticles (PEMPs), enabling clinically-relevant high-frequency neural stimulation of primary neurons under low-intensity focused ultrasound. Owing to its functionally anisotropic design, half of the PEMP acts as a piezoelectric electrode via conjugated barium titanate nanoparticles to induce electrical stimulation, while the nickel-gold nanofilm-coated magnetic half provides spatial and orientational control on neural stimulation via external uniform rotating magnetic fields. Furthermore, surface functionalization with targeting antibodies enables cell-specific binding/targeting and stimulation of dopaminergic neurons. Taking advantage of such functionalities, the PEMP design offers unique features towards wireless neural stimulation for minimally invasive treatment of neurological diseases.