bluuebunny/crossref_metadata_2025_split huggingface dataset:
HYPERBOLICITY AND INVARIANT MANIFOLDS FOR PLANAR NONAUTONOMOUS SYSTEMS ON FINITE TIME INTERVALS
Authors: DUC LUU HOANG , SIEGMUND STEFAN 
Published: June 2008

The method of invariant manifolds was originally developed for hyperbolic rest points of autonomous equations. It was then extended from fixed points to arbitrary solutions and from autonomous equations to nonautonomous dynamical systems by either the Lyapunov–Perron approach or Hadamard's graph transformation. We go one step further and study meaningful notions of hyperbolicity and stable and unstable manifolds for equations which are defined or known only for a finite time, together with matching notions of attraction and repulsion. As a consequence, hyperbolicity and invariant manifolds will describe the dynamics on the finite time interval. We prove an analog of the Theorem of Linearized Asymptotic Stability on finite time intervals, generalize the Okubo–Weiss criterion from fluid dynamics and prove a theorem on the location of periodic orbits. Several examples are treated, including a double gyre flow and symmetric vortex merger.
A NEW MECHANISM FOR INTERMITTENCY IN RINGS OF CELLS
Authors: PARKER MARTYN , STEWART IAN 
Published: June 2008

We discuss a general mechanism that induces periodic switching between different dynamic phenomena in rings of cells. Such intermittent behavior is normally modeled by asymptotically stable heteroclinic cycles. Our mechanism does not require a heteroclinic cycle in the ring of cells, instead a Van der Pol oscillator forces our system so that it periodically changes state. We investigate this mechanism numerically in a number of different examples. These simulations demonstrate a variety of interesting forms of intermittency.
Islam's Popularity: The Case of Indonesia
Authors: Tamney Joseph B. 
Published: June 2008

AbstractIn the parts of the world where it is dominant, Islam is not seen as a peripheral, let alone dying, institution. In Indonesia, where my data is from, it is claimed that "Islam as a religion is in the ascendant." Many mosques are being built, religious radio programs have a large audience, and Islam is penetrating public schools and government (Awanohara, 1985). The power and popularity of the Muslim faith is ' difficult for Westerners to understand because of the intellectual dominance of the modernization-secularization thesis. According to this perspective, as countries become more modern, religion becomes less important. This simplistic view is, of course, being challenged even in the West, yet for most of this century it was the dominant framework for the scientific study of religion in the modern world. The popularity of Islam is not only fascinating in its own right, but also a challenge to the seculari- zation thesis. Is this perspective to be discarded? What ideas must enlarge, or replace, this orientation to explain the reality of Islam? These questions are the focus of this paper.
Memory as Malady and Therapy in Freud and Hegel
Authors: Farrell Krell David 
Published: June 2008

AbstractThe following paper, delivered as a lecture to the philosophy departments of a number of American universities in 1979, traces a parallel between Hegelian phenomenology and Freudian psychoanalysis. It stems from a project I have been working on for several years now entitled Erinnerungsversuch or "Essay in Remembrance. " In my studies of Freud and Hegel for that project I was struck by the importance of memory for their work, not only as a field of investigation but also as a method of the investigation itself. Remembering and forgetting are the crucial events for both psychoanalysis and phenomenology, crucial yet maddeningly intertwined, so that while memory seems eminently subject to malfunction and even illness it remains the sole source of insight and cure. I therefore determined to extend the parallel as far as it would go-perhaps even farther-and the present paper is the result. I am of course aware that Hegel was not a psychotherapist, Freud not a systematic philosopher, and realize that if essays like this one may be excused at all it is only because they eventually grow silent and allow irreconcilable differences to reassert themselves. Yet there is a sense in which Hegel's creative recapitulation of the history of philosophy, seeking as it does to liberate philosophical thought from a crippling self-ignorance, amounts to therapy of spirit; and there is a sense in which Freudian therapy must shatter traditional prejudices in our thoughts about what the psyche or spirit is, by letting psychological phenomena show themselves as they are. I have tried to make the parallel as concrete as possible, shunning Freud's metapsychology and turning instead to one of his earliest accounts of psychoanalytic praxis, eschewing sweeping remarks about Hegel's "system" and concentrating on just a few pages from the Phenomenology. Readers trained in philosophy will know that a few pages of Hegel are bound to contain labyrinths. I hope that my psychologist-readers will overlook the oversimplified presentation of Freud-which results partly from the lecture form-and will forgive my unwillingness to make Hegel's thought seem less demanding than it is. Finally, if I am right, the Freud-Hegel parallel with respect to memory tells us a good deal not only about this fascinating faculty but also about that singular creature who is so ardent to remember and so prone to forget.
The Birth of the Infant: a Developmental Perspective
Authors: Wertz Frederick J. 
Published: June 2008

AbstractPsychological birth is not a single event but occurs again and again throughout one's life. A new psychological structure is bom in each developmental transformation of a person's existence. But what about "biological birth" or what we will call the bodily birth of the infant? Does this involve psychological development? It is not taken up in this way by developmental psychology, which usually begins with the newborn infant Some psychologists have even argued that when an infant leaves the mother's uterus, he is bom biologically but not yet psychologically. In the following paper we will take this view as problematic and address to it a description of the birth process based on the perceptive observations of Frederick Leboyer. Appropriating some of Kegan's notions regarding psychological development,' we will reflect upon the . phenomenon of being bom psychologically. In other words, we will investigate whether and in what sense being bom can be seen as a phenomenon involving psychological development.
The Symbiosis of Towns and Textiles: Urban Institutions and the Changing Fortunes of Cloth Manufacturing in the Low Countries and England, 1270-1570
Authors: Munro John 
Published: June 2008

AbstractThis paper, a contribution to the "proto-industrialization" debate, examines the relative advantages of urban and rural locations for cloth manufacturing in later-medieval England and the Low Countries. From the eleventh to the mid-fourteenth century, when the English cloth trade began its seemingly inexorable expansion, the Low Countries had enjoyed a virtual supremacy in international cloth markets, then chiefly located in the Mediterranean basin. The traditional view has attributed the ultimate English victory to the advantages of a rural location, using cheap labour and water-powered fulling. The proponents of this view further contend that in late thirteenth-century England a new rural industry had displaced a centuries-old "traditional" urban cloth industry through such superior cost advantages. To challenge that view, this paper puts forth the following propositions : (1) that England's traditional urban industry had declined, abruptly from the 1290s, chiefly because of steeply rising, war-induced, transaction costs in Mediterranean markets for its chief products: i.e., cheap and light fabrics, which they had sold as price takers; (2) that the Flemish/Brabantine cloth industries, having had a similar industrial-commercial orientation, suffered from the same industrial crisis; and more quickly responded by reorienting production, as price makers, to the very high-priced luxury woollens; (3) that rural locations were not always more advantageous, in lower labour and other costs; (4) that urban locations offered important benefits for luxury-cloth production : a more highly skilled, productive, better regulated labour force; urban and guild institutions to enforce necessary quality controls and promote international reputations for high quality; (5) that England's cloth industry, when it revived from the 1360s, followed suit in shifting to more luxury-oriented exports, while gaining its chief advantages from the fiscal burdens imposed on high-quality wool exports to its overseas competitors; (6) that English export-oriented cloth production also remained more urban than rural until the late fifteenth century (for many complex reasons explored in this paper).
Asian Despotism? Mughal Government as Seen From the Dutch East India Company Factory in Surat
Authors: Tracy James D. 
Published: June 2008

AbstractIn the current debate about early modern European perceptions of Asia, the rich documentation produced by the Dutch East India Company has been largely overlooked. The Surat factory, whose correspondence is extant from 1636, was in close connection with the centers of Mughal authority, and the factory here, unlike in some other Dutch outposts, was never allowed to be transformed into a fortified enclosure from which the "hatmen" could challenge the agents of the state with impunity. In published accounts of Asian government, including those written in Dutch, "despots" held sway over lands whose only law was the ruler's whim. But Company documents from Surat (and elsewhere in India) consistently depict local officials as manipulating for their own profit their control over European trade, often in flagrant disregard of trading privileges carefully negotiated with the Mughal court. The image of an all-powerful sovereign, though not altogether absent, is sometimes evoked as a way of explaining to Company superiors in Batavia (Djakarta) or Amsterdam why their servants in Surat could not do as they were bidden. But if Company men developed over time a credible local knowledge of Mughal government, they were no different from stay-at-home European Christians in their view of the Mughal realm's Muslim elites: in this age of continuing warfare between Christendom and Islamdom, a "faithless Moor" was always and everywhere the same.
The Work in Gold as Spiritual Journey in Camara Laye's the African Child
Authors: Azodo Ada Uzoamaka 
Published: June 2008

AbstractOf all the different kinds of work my father performed, none fascinated me so much as his skill with gold. No other occupation was so noble, no other needed such a delicate touch; and moreover, this sort of work was always a kind of festival: it was a real festival that broke the monotony of ordinary working days (The African Child, p 22).
3. Missiology or Missiologies?
Authors: Soares-Prabhu George M. 
Published: June 2008

AbstractNo one can fail to be impressed by Professor Spindler's informed and judicious position paper on a new focus for the theology of mission. His survey of recent developments in biblical scholarship and missiological reflection is a model of perceptiveness and clarity, and the case he makes for a shift from 'mission' to 'witness' as the new focus for missiological reflection is persuasive. The paper is well-informed, clear, insightful and thought-provoking. There is little in what it says that I would quarrel with. It is with what it does not say that my questions begin. For Professor Spindler's paper, it seems to me, neglects two related elements which I believe to be important for the discussion of any biblical and missiological issue: (1) sociological context, and (2) hermeneutical method. I shall say a few words about each.
The Things of Heaven Shall Become the Things of Earth
Authors: Aagaard Anna Marie 
Published: June 2008

AbstractThe word of the Lord of Hosts came to me: These are the words of the Lord of Hosts: I have been jealous for Zion, fiercely jelous for her. Now, says the Lord, I have come back to Zion and I will dwell in Jerusalem. Jerusalem shall be called the City of Truth, and the mountain of the Lord of Hosts shall be called the Holy Montain. These are the words of the Lord of Hosts: Once again shall old men and old women sit in the streets of Jerusalem, each leaning on a stick because of their great age; and the streets of the city shall be full of boys and girls, playing in the streets. These are the words of the Lord of Hosts: Even if it may seem impossible to the survivors of this nation on that day, will it also seem impossible to me? This is the very words of the Lord of Hosts. These are the words of the Lord of Hosts: See I will rescue my people from the countries of the east and the west, and bring them back to live in Jerusalem. They shall be my people, and I will be their God, in truth and justice. Zechariah 8,1-8 (NEB)
Forum PAPERs
Authors: Gort Gerald D 
Published: June 2008

AbstractThe purpose of this paper is to provide a birdseye view of the historical Christian attitudes to other religions. It is argued that with the exception of the first 250 years of its existence Christianity's attitude on this score has been predominantly negative, but that from around the turn of the present century a new, more congenial and generous Christian stance has been in the making. With respect to this latter period the examination is limited to developments on the Protestant side of Christianity. An attempt is made to identify some of the more important causal factors involved in the evolution of the newer attitude, whereby particular attention is given to developments in the thinking of the ecumenical movement during its earlier period from 1910-1963.
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
Authors: Yoon Chang Min , Hong Bok Sil , Moon Hyung Geun , Lim Seyoung , Suh Pann-Ghill , Kim Yoon-Keun , Chae Chi-Bom , Gho Yong Song 
Published: June 2008

Abstract
The lymphatic system plays pivotal roles in mediating tissue fluid homeostasis and immunity, and excessive lymphatic vessel formation is implicated in many pathological conditions, which include inflammation and tumor metastasis. However, the molecular mechanisms that regulate lymphatic vessel formation remain poorly characterized. Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that is implicated in a variety of biologic processes such as inflammatory responses and angiogenesis. Here, we first report that S1P acts as a lymphangiogenic mediator. S1P induced migration, capillary-like tube formation, and intracellular Ca2+ mobilization, but not proliferation, in human lymphatic endothelial cells (HLECs) in vitro. Moreover, a Matrigel plug assay demonstrated that S1P promoted the outgrowth of new lymphatic vessels in vivo. HLECs expressed S1P1 and S1P3, and both RNA interference–mediated down-regulation of S1P1 and an S1P1 antagonist significantly blocked S1P-mediated lymphangiogenesis. Furthermore, pertussis toxin, U73122, and BAPTA-AM efficiently blocked S1P-induced in vitro lymphangiogenesis and intracellular Ca2+ mobilization of HLECs, indicating that S1P promotes lymphangiogenesis by stimulating S1P1/Gi/phospholipase C/Ca2+ signaling pathways. Our results suggest that S1P is the first lymphangiogenic bioactive lipid to be identified, and that S1P and its receptors might serve as new therapeutic targets against inflammatory diseases and lymphatic metastasis in tumors.
Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc
Authors: Yakubenia Sviatlana , Frommhold David , Schölch Dirk , Hellbusch Christina C. , Körner Christian , Petri Björn , Jones Claire , Ipe Ute , Bixel M. Gabriele , Krempien Robert , Sperandio Markus , Wild Martin K. 
Published: June 2008

AbstractLeukocyte adhesion deficiency II (LAD II), also known as congenital disorder of glycosylation IIc (CDG-IIc), is a human disease in which a defective GDP-fucose transporter (SLC35C1) causes developmental defects and an immunodeficiency that is based on the lack of fucosylated selectin ligands. Since the study of in vivo leukocyte trafficking in patients with LAD II is experimentally limited, we analyzed this process in mice deficient for Slc35c1. We found that E-, L-, and P-selectin–dependent leukocyte rolling in cremaster muscle venules was virtually absent. This was accompanied by a strong but not complete decrease in firm leukocyte adhesion. Moreover, neutrophil migration to the inflamed peritoneum was strongly reduced by 89%. Previous reports showed surprisingly normal lymphocyte functions in LAD II, which indicated sufficient lymphocyte trafficking to secondary lymphoid organs. We now found that while lymphocyte homing to lymph nodes was reduced to 1% to 2% in Slc35c1−/− mice, trafficking to the spleen was completely normal. In accordance with this, we found a defect in the humoral response to a T cell–dependent antigen in lymph nodes but not in the spleen. Taken together, Slc35c1−/− mice show strongly defective leukocyte trafficking but normal lymphocyte homing to the spleen, which may explain normal lymphocyte functions in LAD II.
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
Authors: Buglio Daniela , Georgakis Georgios V. , Hanabuchi Shino , Arima Kazuhiko , Khaskhely Noor M. , Liu Yong-Jun , Younes Anas 
Published: June 2008

AbstractEpigenetic changes have been implicated in silencing several B-cell genes in Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma (HL), and this mechanism has been proposed to promote HRS survival and escape from immunosurveillance. However, the molecular and functional consequences of histone deacetylase (HDAC) inhibition in HL have not been previously described. In this study, we report that the HDAC inhibitor vorinostat induced p21 expression and decreased Bcl-xL levels causing cell-cycle arrest and apoptosis. Furthermore, vorinostat inhibited STAT6 phosphorylation and decreased its mRNA levels in a dose- and time-dependent manner, which was associated with a decrease in the expression and secretion of Thymus and Activation-Regulated Chemokine (TARC/CCL17) and interleukin (IL)–5 and an increase in IP-10 levels. Moreover, vorino-stat inhibited TARC secretion by dendritic cells that were activated by the thymic stromal lymphopoietin (TSLP). Collectively, these data suggest that pharmacologic HDAC inhibition in HL may induce favorable antitumor activity by a direct antiproliferative effect on HRS cells, and possibly by an immune mediated effect by altering cytokine and chemokines secretion in the microenvironment.
The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways
Authors: Lambert Alexandra A. , Gilbert Caroline , Richard Manon , Beaulieu André D. , Tremblay Michel J. 
Published: June 2008

AbstractThe dynamic interplay between dendritic cells (DCs) and human immunodeficiency virus type-1 (HIV-1) is thought to result in viral dissemination and evasion of antiviral immunity. Although initial observations suggested that the C-type lectin receptor (CLR) DC-SIGN was responsible for the trans-infection function of the virus, subsequent studies demonstrated that trans-infection of CD4+ T cells with HIV-1 can also occur through DC-SIGN–independent mechanisms. We demonstrate that a cell surface molecule designated DCIR (for DCimmunoreceptor), a member of a recently described family of DC-expressing CLRs, can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4+ T cells from human immature monocyte-derived DCs. The contribution of DCIR to these processes was revealed using DCIR-specific siRNAs and a polyclonal antibody specific for the carbohydrate recognition domain of DCIR. Data from transfection experiments indicated that DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection. Finally, we show that the neck domain of DCIR is important for the DCIR-mediated effect on virus binding and infection. These results point to a possible role for DCIR in HIV-1 pathogenesis by supporting the productive infection of DCs and promoting virus propagation.
Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites
Authors: Semnani Roshanak Tolouei , Venugopal Priyanka Goel , Leifer Cynthia A. , Mostböck Sven , Sabzevari Helen , Nutman Thomas B. 
Published: June 2008

Abstract
Patent lymphatic filariasis is characterized by antigen-specific T-cell unresponsiveness with diminished IFN-γ and IL-2 production and defects in dendritic cell (DC) function. Because Toll-like receptors (TLRs) play an important role in pathogen recognition and TLR expression is diminished on B and T cells of filaria-infected individuals, we examined the effect of live microfilariae (mf) on expression and function of TLRs in human DCs. We show that mf-exposed monocyte-derived human DCs (mhDCs) demonstrate marked diminution of TLR3 and TLR4 mRNA expression compared with mf-unexposed mhDCs that translated into loss of function in response to appropriate TLR ligands. Exposure to mf significantly down-regulated production of IFN-α, MIP-1α, IL-12p70, and IL-1α following activation with poly I:C, and of IL-12p40 following activation with poly I:C or LPS. mRNA expression of MyD88, the adaptor molecule involved in TLR4 signaling, was significantly diminished in mhDCs after exposure to mf. Moreover, mf interfered with NF-κB activation (particularly p65 and p50) following stimulation with poly I:C or LPS. These data suggest that mf interfere with mhDC function by altering TLR expression and interfering with both MyD88-dependent signaling and a pathway that ultimately diminishes NF-κB activity. This down-regulated NF-κB activity impairs mhDC-produced cytokines needed for full T-cell activation.
Characterization of Bacillus anthracis arginase: effects of pH, temperature, and cell viability on metal preference
Authors: Viator Ryan J , Rest Richard F , Hildebrandt Ellen , McGee David J 
Published: June 2008

Abstract

Background
Arginase (RocF) hydrolyzes L-arginine to L-ornithine and urea. While previously characterized arginases have an alkaline pH optimum and require activation with manganese, arginase from Helicobacter pylori is optimally active with cobalt at pH 6. The arginase from Bacillus anthracis is not well characterized; therefore, this arginase was investigated by a variety of strategies and the enzyme was purified.

Results
The rocF gene from B. anthracis was cloned and expressed in E. coli and compared with E. coli expressing H. pylori rocF. In the native organisms B. anthracis arginase was up to 1,000 times more active than H. pylori arginase and displayed remarkable activity in the absence of exogenous metals, although manganese, cobalt, and nickel all improved activity. Optimal B. anthracis arginase activity occurred with nickel at an alkaline pH. Either B. anthracis arginase expressed in E. coli or purified B. anthracis RocF showed similar findings. The B. anthracis arginase expressed in E. coli shifted its metal preference from Ni > Co > Mn when assayed at pH 6 to Ni > Mn > Co at pH 9. Using a viable cell arginase assay, B. anthracis arginase increased dramatically when the cells were grown with manganese, even at final concentrations of <1 μM, whereas B. anthracis grown with cobalt or nickel (≥500 μM) showed no such increase, suggesting existence of a high affinity and specificity manganese transporter.

Conclusion
Unlike other eubacterial arginases, B. anthracis arginase displays unusual metal promiscuity. The unique properties of B. anthracis arginase may allow utilization of a specific metal, depending on the in vivo niches occupied by this organism.