bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlations between the ICIQ‐SF score and urodynamic findings
Authors: Seckiner Ilker , Yesilli Cetin , Mungan N. Aydin , Aykanat Adem , Akduman Bulent 
Published: February 2007

AbstractAimsThe primary aim of this prospective study was to examine the correlations between “The International Consultation on Incontinence Questionnaire‐Short Form (ICIQ‐SF)” score and urodynamic findings in patients with urge incontinence. In addition, we aimed to observe the alterations of these parameters with antimuscarinic therapy.MethodsBetween January and December 2005, patients referred to our department with urge incontinence were examined. After taking a detailed clinical history, physical examination, and urinalysis, each patient was asked to complete an ICIQ‐SF questionnaire. We carried out subtracted cystometry according to a fixed protocol on all patients. Patients who were defined as detrusor overactivity incontinent were given antimuscarinic therapy for 3 months. Following treatment, filling cystometry and ICIQ‐SF scoring were repeated in all patients. All pre‐ and post‐treatment data of 18 male and 42 female patients were transferred to the SPSS 11.0 for Windows program, and statistical analyses were performed.ResultsThe patients' ages ranged from 28 to 70 (mean 49.8) years. We found statistically significant differences between the pre‐ and post‐treatment parameters (mean ICIQ‐SF score, first sensation, cystometric capacity, maximum detrusor pressure, compliance; P < 0.01). We found negative correlation between pre‐treatment mean ICIQ‐SF score and first sensation (correlation coefficient −0.266, P < 0.05) and positive correlation between pre‐treatment mean ICIQ‐SF score and maximum detrusor pressure (correlation coefficient 0.4, P < 0.01).ConclusionsICIQ‐SF scoring is a practical and reliable method for baseline and post‐treatment evaluation of patients with urge incontinence. Significant correlation exists between ICIQ‐SF score and urodynamic parameters. Neurourol. Urodynam. 26:492–494, 2007. © 2007 Wiley‐Liss, Inc.
Diamond elements: a finite element/discrete‐mechanics approximation scheme with guaranteed optimal convergence in incompressible elasticity
Authors: Hauret P. , Kuhl E. , Ortiz M. 
Published: February 2007

AbstractWe present a finite element discretization scheme for the compressible and incompressible elasticity problems that possess the following properties: (i) the discretization scheme is defined on a triangulation of the domain; (ii) the discretization scheme is defined—and is identical—in all spatial dimensions; (iii) the displacement field converges optimally with mesh refinement; and (iv) the inf–sup condition is automatically satisfied. The discretization scheme is motivated both by considerations of topology and analysis, and it consists of the combination of a certain mesh pattern and a choice of interpolation that guarantees optimal convergence of displacements and pressures. Rigorous proofs of the satisfaction of the inf–sup condition are presented for the problem of linearized incompressible elasticity. We additionally show that the discretization schemes can be given a compelling interpretation in terms of discrete differential operators. In particular, we develop a discrete analogue of the classical tensor differential complex in terms of which the discrete and continuous boundary‐value problems are formally identical. We also present numerical tests that demonstrate the dimension‐independent scope of the scheme and its good performance in problems of finite elasticity. Copyright © 2007 John Wiley & Sons, Ltd.
NTA‐mediated protein capturing strategy in screening experiments for small organic molecules by surface plasmon resonance
Authors: Yoshitani Naoei , Saito Kazuki , Saikawa Wakana , Asanuma Miwako , Yokoyama Shigeyuki , Hirota Hiroshi 
Published: February 2007

AbstractNitrilotriacetate (NTA)‐mediated capture of a histidine‐tagged protein is widely used as an easy and simple method to reversibly immobilize the protein onto a sensor chip for surface plasmon resonance (SPR). However, in spite of its advantages, the NTA‐capturing strategy is rarely employed for ligand screening experiments using SPR, because it was thought to cause substantial errors in binding responses, due to the inevitable protein dissociation during the monitoring period. In this study, as demonstrated in a ligand screening for the histidine‐tagged SH3 domain of the human phosphatidylinositol 3‐kinase p85α subunit, false responses after adhesion of undesirable compounds to a target protein could be minimized with the NTA strategy, while binding responses of a positive control peptide still stayed within a 1%‐deviation against the theoretical binding capacity.
Proteomic analysis of vascular endothelial cells in response to laminar shear stress
Authors: Wang Xiao‐Li , Fu Alex , Raghavakaimal Sreekumar , Lee Hon‐Chi 
Published: February 2007

AbstractIsotope‐coded affinity tags (cICAT) coupled with mass spectrometric analysis is one of the leading technologies for quantitative proteomic profiling and protein quantification. We performed proteomic analysis of bovine aortic endothelial cells (BAEC) in response to laminar shear stress using cICAT labeling coupled with LC‐MS/MS. Protein expressions in BAEC under 15 dynes/cm2 of shear stress for 10 min, 3 h, and 6 h were compared with matched stationary controls. Analysis of each sample produced 1800–2400 proteins at ≥75% confidence level. We found 142, 213, and 186 candidate proteins that were up‐ or down‐regulated by at least two‐fold after 10 min, 3 h, and 6 h of shear stress, respectively. Some of these proteins have known cellular functions and they encompass many signaling pathways. The signaling pathways that respond to shear stress include those of integrins, G‐protein‐coupled receptors, glutamate receptors, PI3K/AKT, apoptosis, Notch and cAMP‐mediated signaling pathways. The validity of the mass spectrometric analysis was also confirmed by Western blot and confocal immunofluorescence microscopy. The present quantitative proteomic analysis suggests novel potential regulatory mechanisms in vascular endothelial cells in response to shear stress. These results provide preliminary footprints for further studies on the signaling mechanisms induced by shear stress.
Effects of agricultural production systems and their components on protein profiles of potato tubers
Authors: Lehesranta Satu J. , Koistinen Kaisa M. , Massat Nathalie , Davies Howard V. , Shepherd Louise V. T. , McNicol James W. , Cakmak Ismail , Cooper Julia , Lück Lorna , Kärenlampi Sirpa O. , Leifert Carlo 
Published: February 2007

AbstractA range of studies have compared the level of nutritionally relevant compounds in crops from organic and nonorganic farming systems, but there is very limited information on the effect of farming systems and their key components on the protein composition of plants. We addressed this gap by quantifying the effects of different farming systems and key components of such systems on the protein profiles of potato tubers. Tuber samples were produced in the Nafferton factorial systems study, a group of long‐term, replicated factorial field experiments designed to identify and quantify the effect of fertility management methods, crop protection practices and rotational designs used in organic, low input and conventional production systems. Protein profiles were determined by 2‐DE and subsequent protein identification by HPLC‐ESI‐MS/MS. Principal component analysis of 2‐DE data showed that only fertility management practices (organic matter vs. mineral fertiliser based) had a significant effect on protein composition. Quantitative differences were detected in 160 of the 1100 tuber proteins separated by 2‐DE. Proteins identified by MS are involved in protein synthesis and turnover, carbon and energy metabolism and defence responses, suggesting that organic fertilisation leads to an increased stress response in potato tubers.
Anionic lanthanide phenoxide complexes as novel single‐component initiators for the polymerization of ε‐caprolactone and trimethylene carbonate
Authors: Sheng Hongting , Zhou Liying , Zhang Yong , Yao Yingming , Shen Qi 
Published: February 2007

AbstractThe anionic lanthanide‐sodium‐2,6‐di‐tert‐butyl‐phenoxide complexes [Ln(OAr)4][Na(DME)3]·DME (Ln = Nd 1 (neodymium), Sm 2 (samarium), or Gd 3 (gadolium); DME = dimethoxyethane) were synthesized by the reaction of anhydrous LnCl3 with 4 equiv of sodium‐2,6‐di‐tert‐butyl‐phenoxide NaOAr in high yields and structurally characterized. These complexes showed high catalytic activity in the ring‐opening polymerizations of ϵ‐caprolactone (ϵ‐CL) and trimethylene carbonate (TMC). The catalytic activity profoundly depended on the lanthanide metals. The active order of Gd < Sm < Nd for the polymerization of ϵ‐CL and TMC was observed. The polymers obtained with these initiators all showed a unimodal molecular weight distribution, indicating that the [Ln(OAr)4][Na(DME)3]·DME anionic complexes could be used as single‐component initiators. The anionic complex was more efficient than the corresponding neutral complex, Ln(OAr)3(THF)2. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1210–1218, 2007
Factors affecting the sensitivity to acid inhibition in novel acrylates characterized by secondary functionalities
Authors: Kilambi Harini , Konopka Daniel , Stansbury Jeffrey W , Bowman Christopher N 
Published: February 2007

AbstractHere we demonstrate that acrylates exhibit significant rate reductions in the presence of small concentrations of protic acids (0.1–0.5 wt %) compared with the bulk monomer concentration. Dramatically different sensitivities to acid inhibition, differing by up to 2 orders of magnitude, are exhibited for various acrylates. This study examines the various factors that cause enhanced sensitivity toward acid inhibition in novel acrylates characterized by carbamate and cyclic carbonate secondary functionalities. Acid inhibition studies conducted in the presence of a highly polar solvent, such as propylene carbonate, have been performed to determine the impact of overall medium polarity and the extent of acid dissociation on the sensitivity to acid inhibition. The studies depict only a twofold increase in the parameters associated with acid inhibition, upon the addition of 70 wt % propylene carbonate, in comparison with an increase of 2 orders of magnitude for the novel acrylates. These studies indicate that the susceptibility to acid inhibition is primarily determined by the stability of the hypothesized radical–acid complex as well as its propensity to terminate with other species in the system and not by the extent of acid dissociation in the system. Furthermore, it is implied that the stability of the radical–acid complex and its propensity to terminate with other species in the system are dominated by intramolecular interactions. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1287–1295, 2007
2‐Cyanoprop‐2‐yl dithiobenzoate mediated reversible addition–fragmentation chain transfer polymerization of acrylonitrile targeting a polymer with a higher molecular weight
Authors: Liu Xiao‐Hui , Li Yan‐Guo , Lin Ying , Li Yue‐Sheng 
Published: February 2007

AbstractThe reversible addition–fragmentation chain transfer (RAFT) polymerization of acrylonitrile (AN) mediated by 2‐cyanoprop‐2‐yl dithiobenzoate was first applied to synthesize polyacrylonitrile (PAN) with a high molecular weight up to 32,800 and a polydispersity index as low as 1.29. The key to success was ascribed to the optimization of the experimental conditions to increase the fragmentation reaction efficiency of the intermediate radical. In accordance with the atom transfer radical polymerization of AN, ethylene carbonate was also a better solvent candidate for providing higher controlled/living RAFT polymerization behaviors than dimethylformamide and dimethyl sulfoxide. The various experimental parameters, including the temperature, the molar ratio of dithiobenzoate to the initiator, the molar ratio of the monomer to dithiobenzoate, the monomer concentration, and the addition of the comonomer, were varied to improve the control of the molecular weight and polydispersity index. The molecular weights of PANs were validated by gel permeation chromatography along with a universal calibration procedure and intrinsic viscosity measurements. 1H NMR analysis confirmed the high chain‐end functionality of the resultant polymers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1272–1281, 2007
Xanthene dye functionalized norbornenes for the use in ring opening metathesis polymerization
Authors: Sandholzer Martina , Lex Alexandra , Trimmel Gregor , Saf Robert , Stelzer Franz , Slugovc Christian 
Published: February 2007

AbstractA convenient synthetic route towards polymerizable fluorescein, dicholorofluorescein, and eosin dyes is presented. Polymerizability was provided by linking 2‐norbornene carboxylic acid, 11‐bromo‐undecyl ester to the dye's carboxylate functionality. Although the monomers bearing dichlorofluorescein and eosin were obtained in high yield, the related fluorescein bearing monomer could only be obtained in low yield. In the latter case, concurring etherification and esterification led to a product mixture of the desired carboxy modified monomer and a double substituted by‐product. The dye‐monomers were used successfully for the preparation of statistical copolymers with endo,exo‐2,3‐norbornene dicarboxylic acid dimethylester by ROMP. Absorption and luminescence characteristics and, in particular, the acid/base sensitive behavior of the parent dyes were preserved in the monomers and copolymers. The absorption and emission maxima in THF solution and in the solid state were red shifted in comparison to the aqueous samples of the parent dyes. Dye‐copolymers exhibited good film forming properties. Solid state luminescence studies of the copolymers revealed an increasing sensitivity towards NEt3 vapor in the order fluorescein < dichlorofluorescein < eosin bearing copolymer. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1336–1348, 2007
Type A/B behavior and cancer mortality: The confounding/mediating effect of covariates
Authors: Ragland David R. , Brand Richard J. , Fox Bernard H. 
Published: February 2007

AbstractThe role of stress and related factors in cancer etiology and progression has been a subject of conjecture and hypothesis. We analysed the association of type A/B behavior, which can be viewed as a chronic, repetitive stress response, and cancer mortality, using data from a 22‐year follow‐up of the Western Collaborative Group Study. The unadjusted relative hazard between type A/B behavior and total cancer mortality was 1.53 (p= 0.005), indicating an excess risk of cancer mortality in type A subjects of about 50% over that of type B. However, most or all of the association appeared to be confounded or mediated by other risk factors. Cigarette smoking and age were only weakly correlated with type A/B behavior, yet these two variables were so strongly related to cancer mortality that they accounted for about half of the association of type A/B with cancer mortality. The remaining association was found only for mortality of those cancers which are linked to alcohol consumption, suggesting that this remaining association may operate through a link between type A behavior and alcohol consumption. Thus, an unadjusted association between type A/B behavior and cancer mortality was mostly accounted for by cigarette smoking, age, and possibly alcohol consumption.
Overview of psychoneuroimmunological stress‐ and intervention studies in humans with emphasis on the uses of immunological parameters
Authors: Schulz K.‐H. , Schulz H. 
Published: February 2007

AbstractPsychoneuroimmunological stress‐ and intervention studies are summarized and discussed especially with respect to the immunological parameters used. A description is given of the studies on bereavement, on examinations, and on the effects of various psychosocial situations and on experimental manipulations on immunological parameters as well as of intervention studies. Following an analysis of the immunological parameters regarding their susceptibility to psychosocial changes, a model for research in the field of psychoneuroimmunology is presented. This overview reveals that the results of the reviewed studies prove to be inconsistent. Cell counts and mitogen assays are the most frequently used parameters, while NKCA and specific anti‐viral antibodies against latent viruses give the clearest results. When interpreting results of psychoneuroimmunological studies it should be considered that for most of the parameters the pathophysiological relevance is not yet established. A model which connects interrelations between psychosocial conditions, immunological parameters and disease outcome can be useful to categorize and evaluate existing and future studies and also can prevent misleading conclusions. Derived from this model recommendations for future research will be discussed.
Hopes and expectations of swedish cancer patients: Contradictions surrounding patient satisfaction with care
Authors: Tishelman Carol , Sachs Lisbeth 
Published: February 2007

AbstractThis paper presents a study of hopes and expectations concerning the professional health‐care sector, as expressed by a group of Swedish cancer patients. The data are derived from a cross‐sectional interview study of patients diagnosed with a malignant disease at one general hospital in Stockholm in 1987. A seeming discrepancy exists between the problematic situations and experiences described in narrative form by the participants, and the high rate of positive responses to direct questions concerned with satisfaction with care in this study. A combination of data types and an analytic process derived from medical anthropology has been utilized in order to understand the culturally related hopes and expectations which are behind statements of satisfaction with care. Hopes and expectations reflect the perceived breadth and limits of the professional health‐care sector. Patients appear to organize their experiences in manners which ‘work’. General dissatisfaction with care may not be an effective technique for promoting well‐being when diagnosed with a potentially life‐threatening disease. The patients in this study actively avoid dissatisfaction in a number of ways, which include assuming responsibility themselves, accepting the unarticulated as a form of discourse and adapting frameworks for that which is ‘normal’ from the professional sector.
Evaluation of a community‐based cancer support group
Authors: Cella David F. , Sarafian Bernie , Snider Pamela R. , Yellen Suzanne B. , Winicour Patsy 
Published: February 2007

AbstractStimulated by patient need and encouraged by results from randomized studies in academic centers, many community organizations have initiated cancer support groups in order to improve the psychosocial adjustment of people coping with cancer. For a variety of reasons, little research has been done to evaluate these community support groups. The efficacy of cancer support groups, which has been demonstrated in academic centers, therefore awaits demonstration in community settings.This paper provides process and outcome data from 77 people with cancer who completed an 8‐week support group facilitated by licensed and trained mental health professionals in a local community cancer support organization. Similar to the experience of others, participants were primarily female, of European descent, well‐educated, and relatively young (mean age 50 years, S.D. = 12). As predicted, their self‐reported quality of life (as measured by the Functional Living Index—Cancer) improved significantly, paired t = − 2.06, p < 0.05. Five‐point ratings (poor, fair, good, very good, excellent) were assigned either ‘very good’ or ‘excellent’ for the overall group (90%) and facilitator (87%). More detailed ratings of group and facilitator qualities were consistently and strikingly positive. While facilitators were rated positively and appreciated for their presence, peer support exceeded facilitator skill/input as the primary ingredient noted by participants to be the most helpful aspect of the group. Community‐based cancer support groups appear to provide measurable benefit to participants who complete the group. The benefit is consistent with that demonstrated in randomized studies and emphasizes improvement in coping stimulated by mutual support in a safe environment.
Belief in psychological effects on cancer
Authors: Doan Brian D. , Gray Ross E. , Davis Christine S. 
Published: February 2007

AbstractThe present study surveyed 135 oncology care‐givers' and 442 university students' beliefs about psychological influences in cancer. Care‐givers were more sensitive than students to the potential risks of such beliefs and physicians were in general more reserved than other care‐givers. Overall, the majority agreed strongly that psychological factors can influence physical health and that stress and coping style can influence the course of cancer, including its curability. Many also agreed that stress and coping style may be contributing causes of cancer. Both groups rated various psychological tasks and strategies as being very helpful physically to persons with cancer and most indicated that they would adopt such approaches if they themselves had cancer. The paper distinguishes believers from non‐believers and presents a cluster analysis of believers' responses to the claims that psychological factors can influence health and cancer. The distinct patterns of response that emerged provide empirical support for the distinction made by Doan and Gray (1992) between Strong and Weak formulations of psychological influence and for the distinctions made by Northouse and Wortman (1990) between Moral, Compensatory and Medical models of helping and coping. The limitations of the study are addressed along with the implications of the findings for cancer care.
Positive psychosocial adjustment in potential bone marrow transplant recipients: Cancer as a psychosocial transition
Authors: Andrykowski Michael A. , Hunt Jean W. 
Published: February 2007

AbstractMARIANNE J. BRADYThe examination of psychosocial adjustment in cancer patients requires focusing upon both negative psychosocial sequelae, such as anxiety and depression, and positive sequelae, such as improvements in life outlook or interpersonal relationships. Both positive and negative psychosocial, physical and functional change following the diagnosis of cancer was assessed in a sample (n = 133) of individuals with malignant disease undergoing evaluation for bone marrow transplantation. Positive psychosocial sequelae were frequently reported. Comparison of a subset of cancer patients (n = 60) with a matched group of individuals without a history of cancer (i.e. ‘controls’), revealed that controls also reported a surprising degree of positive psychosocial change across a given period of time. The fact that cancer patients equalled or exceeded controls in the likelihood of reporting positive psychosocial change was, however, noteworthy given the context of physical and functional decline shown by cancer patients. It is concluded that cancer should not be viewed as a stressor with uniformly negative outcomes but rather as a transitional event which creates the potential for both positive and negative change.