bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binder Phenotype—Prenatal Diagnosis, Management, and Postnatal Outcome: Insights from a Case Series and Updated Review of the Literature
Authors: Sabu Brinda , Shenoy Dhanya , R. Vidyalekshmy 
Published: April 2024

AbstractBinder phenotype (BP) or maxillonasal dysplasia is a developmental disorder of the anterior part of the maxilla and nasal complex and is characterized by a short nose with a flat nasal bridge, short columella, acute nasolabial angle, perialar flatness, convex upper lip, and tendency to a class III malocclusion. The etiology of BP is heterogeneous with diverse features and outcomes. The ultrasound features of BP are midfacial hypoplasia with verticalized nasal bones, short columella with flattened tip and alar wings, and the nasofrontal angle measuring >140 degrees. In this case series, we present seven cases of BP detected antenatally, their varied etiology, management, and outcomes with a 2-year follow-up. We conclude that the diagnosis of facial dysmorphisms, such as BP, brings a lot of apprehension and agony in the parents amounting to multiple tests and counseling sessions. Physiognomy which is the normal familial appearance should be considered before concluding whether the observed feature is normal or pathological. Accurate diagnosis, adequate testing, and personalized counseling will help in the prevention of needless termination of pregnancies and ensure an optimal perinatal outcome.
The comparison of spatial patterns and factors associated with healthcare provider knowledge in palliative care in various regions of China
Authors: Wang Jingrong , Song Suhang , Mai Gengchen , Teng Xiaohan , Shu Zhiqun , Xu Yifan , Zhang Xiaoyu , Shi Jianwei , Jing Limei 
Published: April 2024

AbstractAs an integral part of the overall life cycle, it is crucial to ensure equity and accessibility to palliative care services at the end of life. The knowledge of healthcare providers has a significant beneficial impact on the quality of palliative care services. This study aimed to compare the nationwide geographic distribution of healthcare providers’ knowledge of palliative care at the provincial level in China and identify the possible factors associated with its geographic disparities. A descriptive cross-sectional study was conducted in all provinces (n = 29) that implemented palliative care pilot programs in China. Data were collected online using a structured questionnaire. The possible factors associated with healthcare providers’ knowledge including economy, demographics, and health, were explored by using exploratory regression and ordinary least squares. In addition, spatial autocorrelation was also examined with Moran’s I, LISA, and Geographically Weighted Regression. A total of 18,272 participants from 903 health institutions in 87 palliative care pilot cities were included across 29 out of 31 provinces in China. The average knowledge score (mean ± standard deviation [SD]) was 8.61 ± 2.85. A positive spatial correlation was observed in healthcare providers’ palliative care knowledge level in China. The high level of knowledge was significantly associated with fewer hospitals per 10,000 population (β = −0.384, 95% CI: −0.601 to −0.168, p = 0.001), more primary healthcare institutions per 10,000 population (β = 0.220, 95% CI: 0.032–0.407, p = 0.024), and more community health center visits (β = 0.259, 95% CI: 0.054–0.465, p = 0.016), with higher coefficients being observed in the northwest and northeast regions. This study suggested that the knowledge level of palliative care among healthcare providers nationwide was relatively low, indicating the existence of a disparity between the supply and demand of palliative care services. There may be regional disparities in palliative care services based on the substantial geographical variation in healthcare provider knowledge, emphasizing the necessity of tailored interventions targeting areas with the greatest need.
Understanding government support for rural development in Hubei Province, China
Authors: Zhang Hongwei , Wang Zhanqi , Chai Ji 
Published: April 2024

AbstractQuantifying the spatiotemporal characteristics of government support for rural development is crucial for accurately optimizing or formulating policies for rural development, but research identifying government support for rural development at the geospatial scale has not yet emerged. This paper used Hubei Province, China, as the study area and constructed indicators of government support for rural development based on the intensity of support, the spatial direction of support, and the spatial agglomeration of support based on the characteristics of legal rural construction land allocation. Panel data regression was used to quantify the direction of rural development that requires the allocation of rural construction land based on government support. The results showed that government support for rural development through legal rural construction land allocation has strong spatiotemporal characteristics: From 2009 to 2018, the intensity of support grew, the spatial direction of support was regular, and government support was increasingly manifested as local agglomeration. The orientations of government support through legal rural construction land allocation for rural development include farmers’ production, farmers’ livelihoods and social security. This research provides a reference for quantifying government support through legal rural construction land allocation for rural development and the direction of government support.
Determination of optimum printing direction of the polycarbonate parts produced by additive manufacturing
Authors: Akgümüş Gök Dilşad 
Published: April 2024

Abstract
In this study, the effect of printing direction on the tensile properties of polycarbonate (PC) parts produced using a 3D printer was investigated. A total of 9 samples were produced with printing directions of 0°, 45° and 90° with infill density of 20%. Tensile tests were carried out to determine the maximum tensile strength (UTS) of the samples. As a result of the research, it was determined that the samples produced in the same direction as the tensile direction (0° printing direction) had the highest strength values; on the other hand, samples produced in the 90° printing direction have the lowest strength values. While the ultimate tensile strength values for samples produced in 0° printing direction were measured respectively as 22.4 MPa, 21.6 MPa and 20.7 MPa; as 7.1 MPa, 9.1 MPa and 9.2 MPa in 45° printing direction; it was determined as 7.2 MPa, 5.4 MPa and 5.8 MPa in the 90° printing direction. In addition, UTS/mass ratios were calculated by measuring the mass of the samples after the tensile test. According to the results obtained, samples in the 0° printing direction have the highest UTS/mass ratio compared to other printing directions, making them the most durable option for applications requiring lightweight structures. Tensile samples produced in FDM were analyzed with the finite element method (FEM) and analysis results were found to be equivalent to physical tests. This study contributes to examination of the influence of 3D printing direction, especially exposed to tensile, on material properties, and provides important information for the production of lightweight and high strength PC components in industries such as medicine, aerospace and automotive.
Trapping
Ba+
with seven-fold enhanced efficiency utilizing an autoionizing resonance
Authors: Greenberg Noah , White Brendan M , Low Pei Jiang , Senko Crystal 
Published: April 2024

Abstract
Trapped ions have emerged as a front runner in quantum information processing due to their identical nature, all-to-all connectivity, and high fidelity quantum operations. As current trapped ion technologies are scaled, it will be important to improve the efficiency of loading ions, especially when working with long chains of ions or rare isotopes. Here, we compare two different isotope-selective photoionization schemes for loading

138

Ba

+

ions. We show that a two-step photoionization scheme ending in an autoionizing transition increases the ion loading rate nearly an order of magnitude compared to an established technique which does not excite an autoionizing state. Our novel photoionization scheme can be extended to all isotopes of barium. Given that autoionizing resonances exist in every trapped ion species, exploitation of this process is a promising pathway to increase the loading rates for trapped ion computers.
The Metamorphosis of Patient Priorities Throughout the Breast Reconstruction Process
Authors: Davison Steven P , Ellor Molly , LaBove Gabrielle 
Published: April 2024

Abstract

Background
Breast reconstruction is a lengthy, multistage process guided by patients. It is vital to understand how their goals vary over time to achieve optimal outcomes.

Objectives
This study aimed to evaluate how breast reconstruction patients' priorities changed throughout the reconstructive process.

Methods
Fifty women who underwent immediate breast reconstruction completed a quality of life survey at their preoperative appointment, 3, 6, and 12 months after surgery, and then again 10 years later. Scores on the survey's subsections corresponded to different patient priorities: survival, restitution, symmetry, and enhancement. The relationship between time and survey-measured patient priorities was analyzed with mixed-effects regression models and Tukey's HSD (honestly significant difference) tests were performed to make pairwise comparisons between time points.

Results
Survival scores decreased between 3 and 12 months after surgery (P &lt; .001) before returning to baseline at long-term follow-up. Restitution scores were decreased only at 12 months postoperatively (T3 vs T0, T1, and T2, P &lt; .001; T3 vs T4, P = .003). Symmetry scores increased from preoperatively to 6 months postoperatively (P &lt; .001), and then fell back to baseline by month 12 (P &lt; .001) and remained at that level at long-term follow-up. Enhancement scores increased from preoperatively to 12 months after surgery (P &lt; .001), before returning to baseline at 10-year follow-up (T0 vs T4, P &gt; .99; T3 vs T4, P &lt; .001). Time had an overall significant effect on each subsection score (P &lt; .001), but this relationship was restricted to certain time points.

Conclusions
In the year following immediate breast reconstruction, patients' concern over their physical health decreases while they become increasingly focused on enhancing the appearance of their reconstructed breasts. However, by 10 years after surgery, patients' priorities were virtually unchanged from their preoperative desires.

Level of Evidence: 3
Enhancing cryo-EM structure prediction with DeepTracer and AlphaFold2 integration
Authors: Chen Jason , Zia Ayisha , Luo Albert , Meng Hanze , Wang Fengbin , Hou Jie , Cao Renzhi , Si Dong 
Published: April 2024

Abstract
Understanding the protein structures is invaluable in various biomedical applications, such as vaccine development. Protein structure model building from experimental electron density maps is a time-consuming and labor-intensive task. To address the challenge, machine learning approaches have been proposed to automate this process. Currently, the majority of the experimental maps in the database lack atomic resolution features, making it challenging for machine learning-based methods to precisely determine protein structures from cryogenic electron microscopy density maps. On the other hand, protein structure prediction methods, such as AlphaFold2, leverage evolutionary information from protein sequences and have recently achieved groundbreaking accuracy. However, these methods often require manual refinement, which is labor intensive and time consuming. In this study, we present DeepTracer-Refine, an automated method that refines AlphaFold predicted structures by aligning them to DeepTracers modeled structure. Our method was evaluated on 39 multi-domain proteins and we improved the average residue coverage from 78.2 to 90.0% and average local Distance Difference Test score from 0.67 to 0.71. We also compared DeepTracer-Refine with Phenixs AlphaFold refinement and demonstrated that our method not only performs better when the initial AlphaFold model is less precise but also surpasses Phenix in run-time performance.
Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease
Authors: Zaniker Emily J , Zhang Man , Hughes Lydia , La Follette Lizellen , Atazhanova Tomiris , Trofimchuk Alexis , Babayev Elnur , Duncan Francesca E 
Published: April 2024

Abstract
The ovary is one of the first organs to show overt signs of aging in the human body, and ovarian aging is associated with a loss of gamete quality and quantity. The age-dependent decline in ovarian function contributes to infertility and an altered endocrine milieu, which has ramifications for overall health. The aging ovarian microenvironment becomes fibro-inflammatory and stiff with age, and this has implications for ovarian physiology and pathology, including follicle growth, gamete quality, ovulation dynamics, and ovarian cancer. Thus, developing a non-invasive tool to measure and monitor the stiffness of the human ovary would represent a major advance for female reproductive health and longevity. Shear wave elastography is a quantitative ultrasound imaging method for evaluation of soft tissue stiffness. Shear wave elastography has been used clinically in assessment of liver fibrosis and characterization of tendinopathies and various neoplasms in thyroid, breast, prostate, and lymph nodes as a non-invasive diagnostic and prognostic tool. In this study, we review the underlying principles of shear wave elastography and its current clinical uses outside the reproductive tract as well as its successful application of shear wave elastography to reproductive tissues, including the uterus and cervix. We also describe an emerging use of this technology in evaluation of human ovarian stiffness via transvaginal ultrasound. Establishing ovarian stiffness as a clinical biomarker of ovarian aging may have implications for predicting the ovarian reserve and outcomes of Assisted Reproductive Technologies as well as for the assessment of the efficacy of emerging therapeutics to extend reproductive longevity. This parameter may also have broad relevance in other conditions where ovarian stiffness and fibrosis may be implicated, such as polycystic ovarian syndrome, late off target effects of chemotherapy and radiation, premature ovarian insufficiency, conditions of differences of sexual development, and ovarian cancer.
Summary sentence:
Shear Wave Elastography is a non-invasive technique to study human tissue stiffness, and here we review its clinical applications and implications for reproductive health and disease.
From Parking Tickets to the Pandemic: Fixed Penalty Notices, Inequity and the Regulation of Everyday Behaviours
Authors: Murray Kath , McVie Susan , Matthews Ben , Gorton Victoria 
Published: April 2024

Abstract
Since the 1960s, Fixed Penalty Notices (FPNs) have become a widely used sanction in the United Kingdom, used to deal with various low-level offences. More recently, the sanction came to prominence as the mechanism chosen to enforce the Coronavirus Health Regulations. This article critically examines the decision to employ FPNs in this context, and the implications in respect of inequality and inequity. We show that the decision was at odds with contemporaneous policing trends, and, drawing on new research evidence, argue that the Regulations stretched FPNs beyond their intended use, creating inequalities in enforcement and inequitable punishment effects. Our findings raise policy questions about the impact of the Health Regulations and what actions should be taken in the event of future pandemics.
Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults
Authors: Rinne Nea , Wikman Patrik , Sahari Elisa , Salmi Juha , Einarsdóttir Elisabet , Kere Juha , Alho Kimmo 
Published: April 2024

Abstract
Reading skills and developmental dyslexia, characterized by difficulties in developing reading skills, have been associated with brain anomalies within the language network. Genetic factors contribute to developmental dyslexia risk, but the mechanisms by which these genes influence reading skills remain unclear. In this preregistered study (https://osf.io/7sehx), we explored if developmental dyslexia susceptibility genes DNAAF4, DCDC2, NRSN1, and KIAA0319 are associated with brain function in fluently reading adolescents and young adults. Functional MRI and task performance data were collected during tasks involving written and spoken sentence processing, and DNA sequence variants of developmental dyslexia susceptibility genes previously associated with brain structure anomalies were genotyped. The results revealed that variation in DNAAF4, DCDC2, and NRSN1 is associated with brain activity in key language regions: the left inferior frontal gyrus, middle temporal gyrus, and intraparietal sulcus. Furthermore, NRSN1 was associated with task performance, but KIAA0319 did not yield any significant associations. Our findings suggest that individuals with a genetic predisposition to developmental dyslexia may partly employ compensatory neural and behavioral mechanisms to maintain typical task performance. Our study highlights the relevance of these developmental dyslexia susceptibility genes in language-related brain function, even in individuals without developmental dyslexia, providing valuable insights into the genetic factors influencing language processing.
Early-stage use of hearing aids preserves auditory cortical structure in children with sensorineural hearing loss
Authors: Yuan Di , Tournis Elizabeth , Ryan Maura E , Lai Ching Man , Geng Xiujuan , Young Nancy M , Wong Patrick C M 
Published: April 2024

Abstract
Hearing is critical to spoken language, cognitive, and social development. Little is known about how early auditory experiences impact the brain structure of children with bilateral sensorineural hearing loss. This study examined the influence of hearing aid use and residual hearing on the auditory cortex of children with severe to profound congenital sensorineural hearing loss. We evaluated cortical preservation in 103 young pediatric cochlear implant candidates (55 females and 48 males) by comparing their multivoxel pattern similarity of auditory cortical structure with that of 78 age-matched children with typical hearing. The results demonstrated that early-stage hearing aid use preserved the auditory cortex of children with bilateral congenital sensorineural hearing loss. Children with less residual hearing experienced a more pronounced advantage from hearing aid use. However, this beneficial effect gradually diminished after 17 months of hearing aid use. These findings support timely fitting of hearing aids in conjunction with early implantation to take advantage of neural preservation to maximize auditory and spoken language development.
Morphological correlates of pyramidal cell axonal myelination in mouse and human neocortex
Authors: Pascual-García Maria , Unkel Maurits , Slotman Johan A , Bolleboom Anne , Bouwen Bibi , Houtsmuller Adriaan B , Dirven Clemens , Gao Zhenyu , Hijazi Sara , Kushner Steven A 
Published: April 2024

Abstract
The axons of neocortical pyramidal neurons are frequently myelinated. Heterogeneity in the topography of axonal myelination in the cerebral cortex has been attributed to a combination of electrophysiological activity, axonal morphology, and neuronal–glial interactions. Previously, we showed that axonal segment length and caliber are critical local determinants of fast-spiking interneuron myelination. However, the factors that determine the myelination of individual axonal segments along neocortical pyramidal neurons remain largely unexplored. Here, we used structured illumination microscopy to examine the extent to which axonal morphology is predictive of the topography of myelination along neocortical pyramidal neurons. We identified critical thresholds for axonal caliber and interbranch distance that are necessary, but not sufficient, for myelination of pyramidal cell axons in mouse primary somatosensory cortex (S1). Specifically, we found that pyramidal neuron axonal segments with a caliber &lt; 0.24 μm or interbranch distance &lt; 18.10 μm are rarely myelinated. Moreover, we further confirmed that these findings in mice are similar for human neocortical pyramidal cell myelination (caliber &lt; 0.25 μm, interbranch distance &lt; 19.00 μm), suggesting that this mechanism is evolutionarily conserved. Taken together, our findings suggest that axonal morphology is a critical correlate of the topography and cell-type specificity of neocortical myelination.
Action video games and posterior parietal cortex neuromodulation enhance both attention and reading in adults with developmental dyslexia
Authors: Bertoni Sara , Franceschini Sandro , Mancarella Martina , Puccio Giovanna , Ronconi Luca , Marsicano Gianluca , Gori Simone , Campana Gianluca , Facoetti Andrea 
Published: April 2024

Abstract
The impact of action video games on reading performance has been already demonstrated in individuals with and without neurodevelopmental disorders. The combination of action video games and posterior parietal cortex neuromodulation by a transcranial random noise stimulation could enhance brain plasticity, improving attentional control and reading skills also in adults with developmental dyslexia. In a double blind randomized controlled trial, 20 young adult nonaction video game players with developmental dyslexia were trained for 15 h with action video games. Half of the participants were stimulated with bilateral transcranial random noise stimulation on the posterior parietal cortex during the action video game training, whereas the others were in the placebo (i.e. sham) condition. Word text reading, pseudowords decoding, and temporal attention (attentional blink), as well as electroencephalographic activity during the attentional blink, were measured before and after the training. The action video game + transcranial random noise stimulation group showed temporal attention, word text reading, and pseudoword decoding enhancements and P300 amplitude brain potential changes. The enhancement in temporal attention performance was related with the efficiency in pseudoword decoding improvement. Our results demonstrate that the combination of action video game training with parietal neuromodulation increases the efficiency of visual attention deployment, probably reshaping goal-directed and stimulus-driven fronto-parietal attentional networks interplay in young adults with neurodevelopmental conditions.