bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Low Omega-3 Index and High AA/EPA Ratio in American College Football Players are Both Improved Following 5 Weeks of DHA-Rich Algae Oil Supplementation
Authors: Larkin Theresa A. , McKay Benjamin , Sampson John A. , Delaney Jace , Murray Andrew , Pedlar Charles R. , Lewis Nathan A. , Peoples Gregory E. 
Published: March 2024

Abstract
Purpose
Many athletes are deficient in long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA). A consequent low Omega-3 Index (O3I) and high arachidonic acid/eicosapentaenoic acid (AA/EPA) ratio increase cardiovascular disease risk and inflammation. Algae oil is a plant-based, sustainable source of LC n-3 PUFA, suitable for vegans and vegetarians. Effects of algae oil supplementation on whole blood fatty acids among athletes has not been previously reported. This study evaluated the effects of 5 weeks of DHA-rich algae oil supplementation on the whole blood fatty acid profile, O3I and AA/EPA ratio of omnivorous Division I American College Football (ACF) players. Methods: Data, including a spot blood sample, were collected at baseline for all participants (n = 47), then for a subset of players (n = 22) following a 5-week control period (usual diet) and 5 weeks of algae oil supplementation (usual diet + 1575 mg docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) 5 days/week; average 1125 mg/day). Results: Baseline O3I was 4.3% ± 0.1% and AA/EPA ratio was 45.6 ± 23.8. After 5 weeks of algae oil supplementation, the O3I was 6.1% ± 1.0% and the AA/EPA ratio was 25.1 ± 11.6. The O3I was significantly higher and the AA/EPA ratio was significantly lower (P < 0.0001 for both) compared with both baseline and the end of the control period. The increase in O3I from baseline was correlated with calculated DHA + EPA dose per unit body mass (R = 0.641, P = 0.001). Conclusions: Algae oil supplementation for 5 weeks improved both the low baseline O3I and high AA/EPA ratio among ACF players, with body mass specific dose effects.
High Intensity Functional Training for Patients Diagnosed with Cancer: A Study Evaluating the Feasibility of a Pragmatic Intervention
Authors: Christensen Jan , Hessner Andreas L. , Sommer Maja S. , Daugaard Rikke , Larsen Rasmus T. 
Published: March 2024

Abstract
Purpose
To investigate the feasibility of a municipality-based 16-week group-based HIFT-program (e.g. CrossFit) as a part of the physical rehabilitation of cancer survivors at different stages of cancer treatment.

Methods
Non-randomised clinical feasibility study. Younger adult patients (age 18–44 years) diagnosed with cancer who were referred to rehabilitation between August 2019 to December 2019 were eligible for inclusion. The group-based HIFT intervention was designed as a 16-week program with two sessions weekly (1.25 h each). The intervention program was not developed with pre-defined progression in terms of gradually added resistance, intensity, or volume during the 16 weeks period but the physiotherapist leading the sessions was trained in scalability. Feasibility was evaluated as retention, adherence, and accrual rates. Data on quality of life and cancer-related fatigue were measured EORTC QLQ-C-30 and evaluated using paired t-tests or Wilcoxon signed-rank test.

Results
Eighty-three percent of the eligible patients were included and initiated the HIFT program. However, 25% of the patients were not adherent to the intervention and only 34% of the patients were still adherent to the intervention after 4 months. Nonetheless, a significant improvement in cancer specific HRQoL was found from baseline [Mean = 53.4, 95%CI (47.6, 59.1)] to the end of the intervention [Mean = 66.3, 95%CI (60.8, 71.9)].

Conclusion
It is possible to recruit patients diagnosed with cancer to a municipality-based HIFT rehabilitation program, however, adherence to the intervention is found to be difficult for the majority of the patients.
Synthesis of glass FRP-natural fiber hybrid composites (NFHC) and its mechanical characterization
Authors: Pawar Unmesh S. , Chavan Sachin S. , Mohite Dadaso D. 
Published: March 2024

AbstractThis research paper presents the synthesis of Glass-Fiber Reinforced Plastic (Glass-FRP) and Natural Fiber-Hybrid Composites (NFHC) using Hand Lay-up techniques. The aim of the this research is on assessing mechanical characteristics of composites made from different natural fibers, including jute, flax, coir, and hair fibers. The study sought to evaluate the influence of natural fiber addition on mechanical characteristics of the composite material and to emphasize the significance of altering fiber type, orientation, resin type, and curing conditions to optimize composite characteristics for particular applications. The mechanical characteristics of these composites were evaluated using tensile and flexural testing. This study significantly enhances the mechanical properties of Glass-FRP composites by incorporating Jute fibers, showcasing a superior tensile strength of 71.29 MPa and the highest flexural strength of 67.73 MPa. The investigation showed that the combination of natural and glass fibers may produce a lightweight, highly-strengthen composite material with enhanced mechanical characteristics that can be employed in a wide range of technical applications.
Remembering the Dead: Postmortem Guild Membership in Late Medieval England
Authors: Harkes Rachael 
Published: March 2024

AbstractAs in many areas of pre-Reformation devotion, the dead were a conspicuous presence in English religious guilds of all sizes. Members joined in the expectation that the guild would say prayers and perform masses for their souls after death, and previous members and benefactors would be commemorated with regularity. This article, however, investigates a new avenue of the fraternal relationship with the dead: the practice of enrolling people after their death. Doing so shifts the paradigm of our understanding of the multidimensional functions of pre-Reformation society, commemoration, and guilds, privileging the experiences of both the dead and living equally, while highlighting the interplay of the spiritual and socioeconomic. Taking the extensive membership records of England's “great” guilds as its basis, this article reveals that postmortem enrollment was a practice both common and widespread, and it addresses questions of practicalities and motivations. As such, the richness of commemoration in late medieval society is demonstrated, and the importance of postmortem membership brought to the fore.
Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm
Authors: Lajmi Nesrine , Alves-Vasconcelos Sofia , Tsiachristas Apostolos , Haworth Andrew , Woods Kerrie , Crichton Charles , Noble Theresa , Salih Hizni , Várnai Kinga A. , Branford-White Harriet , Orrell Liam , Osman Andrew , Bradley Kevin M. , Bonney Lara , McGowan Daniel R. , Davies Jim , Prime Matthew S. , Hassan Andrew Bassim 
Published: March 2024

Abstract
The personalised oncology paradigm remains challenging to deliver despite technological advances in genomics-based identification of actionable variants combined with the increasing focus of drug development on these specific targets. To ensure we continue to build concerted momentum to improve outcomes across all cancer types, financial, technological and operational barriers need to be addressed. For example, complete integration and certification of the ‘molecular tumour board’ into ‘standard of care’ ensures a unified clinical decision pathway that both counteracts fragmentation and is the cornerstone of evidence-based delivery inside and outside of a research setting. Generally, integrated delivery has been restricted to specific (common) cancer types either within major cancer centres or small regional networks. Here, we focus on solutions in real-world integration of genomics, pathology, surgery, oncological treatments, data from clinical source systems and analysis of whole-body imaging as digital data that can facilitate cost-effectiveness analysis, clinical trial recruitment, and outcome assessment. This urgent imperative for cancer also extends across the early diagnosis and adjuvant treatment interventions, individualised cancer vaccines, immune cell therapies, personalised synthetic lethal therapeutics and cancer screening and prevention. Oncology care systems worldwide require proactive step-changes in solutions that include inter-operative digital working that can solve patient centred challenges to ensure inclusive, quality, sustainable, fair and cost-effective adoption and efficient delivery. Here we highlight workforce, technical, clinical, regulatory and economic challenges that prevent the implementation of precision oncology at scale, and offer a systematic roadmap of integrated solutions for standard of care based on minimal essential digital tools. These include unified decision support tools, quality control, data flows within an ethical and legal data framework, training and certification, monitoring and feedback. Bridging the technical, operational, regulatory and economic gaps demands the joint actions from public and industry stakeholders across national and global boundaries.
Prayer for Family and Friends: The Body and Religion in Eighteenth-Century Britain
Authors: Harvey Karen , Vine Emily 
Published: March 2024

AbstractThis article explores how writers, predominantly adhering to a variety of different Christian denominations but also including Jewish writers, discussed religion and the body in letters throughout the long eighteenth century. It draws on a corpus of over 2,500 familiar letters written by men and women of different denominations between 1675 and 1820. That these letters were not chosen because of their religious content makes them a good ‘test’ of the role of faith in everyday understandings of the body. This article underscores the continued centrality of religious discourse and devotional practice in eighteenth-century everyday life. Our research finds that religion was a commonplace register deployed when discussing bodily matters throughout the long eighteenth century. Significantly, this was the case for individuals who otherwise made scant reference to their faith. Discussion of the physical body encouraged recourse to providence, a public discussion of doctrine, and the shared expression of devotion. The ongoing force of religion in people’s lives was thus intimately tied to their embodied experiences. Letters not only expressed but actively maintained this widely shared religious framework for understanding the body.
Trinity, simplicity, and contradictory theology: a theologian's reflections
Authors: McCall Thomas H. 
Published: March 2024

AbstractI explore the promise of Beall's proposal for a long-standing challenge for traditional theology. I first offer a sketch of the problem and a brief overview of some of the more common responses to it. I then show how Beall's proposal holds initial promise; following this I highlight some concerns and raise some questions.
The Principal Principle and the contingent a priori
Authors: Bradley Richard 
Published: March 2024

AbstractIn Chapter 6 of Objects of Credence, Anna Mahtani argues that the opacity of credence raises difficulties for the Principal Principle and proposes a revised principle relating credence and chance that avoids it. In this comment on her book, I both defend Mahtani’s proposed principle against a charge of triviality and argue that the opacity of belief does not threaten the role of chance in guiding credence.
NT-proBNP cardiac value in COVID-19: a focus on the paediatric population
Authors: Sleem Bshara , El Rassi Christophe , Zareef Rana , Bitar Fadi , Arabi Mariam 
Published: March 2024

AbstractNT-proBNP is a peptide related to brain natriuretic peptide, a cardiac biomarker and a member of the natriuretic family of peptides. NT-proBNP has demonstrated its clinical utility in the assessment of a wide spectrum of cardiac manifestations. It is also considered a more precise diagnostic and prognostic cardiac biomarker than brain natriuretic peptide. With the appearance of the Severe Acute Respiratory Syndrome Coronavirus 2 virus and the subsequent COVID-19 pandemic, diagnosis of heart implications began to pose an increasing struggle for the physician. Echocardiography is considered a central means of evaluating cardiac disorders like heart failure, and it is considered a reliable method. However, other diagnostic methods are currently being explored, one of which involves the assessment of NT-proBNP levels. In the literature that involves the adult population, significant positive correlations were drawn between the levels of NT-proBNP and COVID-19 outcomes such as high severity and fatality. In the paediatric population, however, the literature is scarce, and most of the investigations assess NT-proBNP in the context of Multiple Inflammatory Syndrome in Children, where studies have shown that cohorts with this syndrome had elevated levels of NT-proBNP when compared to non-syndromic cohorts. Thus, more large-scale studies on existing COVID-19 data should be carried out in the paediatric population to further understand the prognostic and diagnostic roles of NT-proBNP.
Environmentally Induced Displacement: When (Ecological) Vulnerability Turns into Resilience (and Asylum)
Authors: Ippolito Francesca 
Published: March 2024

ABSTRACTThis article aims to reflect on ‘ecological vulnerability’ – which makes evident the relationship, flows and interactions between the human being/body and the environment/non-human world – as applied in the context of environmentally induced migration. In particular, the dual role of the law vis-à-vis environmentally displaced migrants as a generator and exacerbator of their vulnerability as well as potential antidote, valuable for attaining protection, will be highlighted. Namely, on one hand, the analysis will show how a lack of conceptualisation of the notion to understand the spatial and temporal patterns of climate change-related migration, as well as its consequences for societal well-being, contributes to generate and exacerbate the vulnerability of that category of migrants. On the other hand, the critical understanding of vulnerability, as developed in some recent legal reasoning of international and national jurisdictions, will be proposed as a key element for ensuring the resilience of both environmental migrants and the law itself, for both virtuously expanding traditional asylum norms and flexibilising access to international protection for those migrants.
Interpretable zero-inflated neural network models for predicting admission counts
Authors: Jose Alex , Macdonald Angus S. , Tzougas George , Streftaris George 
Published: March 2024

AbstractIn this paper, we construct interpretable zero-inflated neural network models for modeling hospital admission counts related to respiratory diseases among a health-insured population and their dependants in the United States. In particular, we exemplify our approach by considering the zero-inflated Poisson neural network (ZIPNN), and we follow the combined actuarial neural network (CANN) approach for developing zero-inflated combined actuarial neural network (ZIPCANN) models for modeling admission rates, which can accommodate the excess zero nature of admission counts data. Furthermore, we adopt the LocalGLMnet approach (Richman & Wüthrich (2023). Scandinavian Actuarial Journal, 2023(1), 71–95.) for interpreting the ZIPNN model results. This facilitates the analysis of the impact of a number of socio-demographic factors on the admission rates related to respiratory disease while benefiting from an improved predictive performance. The real-life utility of the methodologies developed as part of this work lies in the fact that they facilitate accurate rate setting, in addition to offering the potential to inform health interventions.
Quantifying Anthropogenic Influences on Global Wave Height Trend During 1961–2020 With Focus on Polar Ocean
Authors: Patra Anindita , Dodet Guillaume , Min Seung‐Ki , Hochet Antoine 
Published: March 2024

AbstractThis study investigates the contribution of external forcings on global and regional ocean wave height change during 1961–2020. Historical significant wave height (Hs) produced for different CMIP6 external forcings and preindustrial control conditions following the Detection and Attribution Model Intercomparison Project (DAMIP) are employed. The internal variability ranges are compared with different external forcing scenario. Statistically significant linear trends in Hs computed over regional ocean basins are found to be mostly associated with anthropogenic forcings: greenhouse gas‐only (GHG) and aerosol‐only (AER) forcing. For Hs, GHG signals are robustly detected and dominant for most of the global ocean, except over North pacific and South Atlantic, where AER signals are dominant. These results are supported by multi‐model analysis for wind speed. The remarkable increase in Hs over the Arctic (22.3%) and Southern (8.2%) Ocean can be attributed to GHG induced sea‐ice depletion and larger effective fetch along with wind speed increase.
Active forgetting and neuropsychiatric diseases
Authors: Berry Jacob A. , Guhle Dana C. , Davis Ronald L. 
Published: March 2024

AbstractRecent and pioneering animal research has revealed the brain utilizes a variety of molecular, cellular, and network-level mechanisms used to forget memories in a process referred to as “active forgetting”. Active forgetting increases behavioral flexibility and removes irrelevant information. Individuals with impaired active forgetting mechanisms can experience intrusive memories, distressing thoughts, and unwanted impulses that occur in neuropsychiatric diseases. The current evidence indicates that active forgetting mechanisms degrade, or mask, molecular and cellular memory traces created in synaptic connections of “engram cells” that are specific for a given memory. Combined molecular genetic/behavioral studies using Drosophila have uncovered a complex system of cellular active-forgetting pathways within engram cells that is regulated by dopamine neurons and involves dopamine-nitric oxide co-transmission and reception, endoplasmic reticulum Ca2+ signaling, and cytoskeletal remodeling machinery regulated by small GTPases. Some of these molecular cellular mechanisms have already been found to be conserved in mammals. Interestingly, some pathways independently regulate forgetting of distinct memory types and temporal phases, suggesting a multi-layering organization of forgetting systems. In mammals, active forgetting also involves modulation of memory trace synaptic strength by altering AMPA receptor trafficking. Furthermore, active-forgetting employs network level mechanisms wherein non-engram neurons, newly born-engram neurons, and glial cells regulate engram synapses in a state and experience dependent manner. Remarkably, there is evidence for potential coordination between the network and cellular level forgetting mechanisms. Finally, subjects with several neuropsychiatric diseases have been tested and shown to be impaired in active forgetting. Insights obtained from research on active forgetting in animal models will continue to enrich our understanding of the brain dysfunctions that occur in neuropsychiatric diseases.
Identification of unique rectal cancer-specific subtypes
Authors: Kisakol Batuhan , Matveeva Anna , Salvucci Manuela , Kel Alexander , McDonough Elizabeth , Ginty Fiona , Longley Daniel B. , Prehn Jochen H. M. 
Published: March 2024

Abstract
Background
Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon and rectal tissues. Moreover, locally advanced rectal cancers at resection often have received neoadjuvant chemoradiotherapy which likely has a significant impact on gene expression.

Methods
We collected mRNA expression profiles for rectal and colon cancer samples (n = 2121). We observed that (i) Consensus Molecular Subtyping (CMS) had a different prognosis in treatment-naïve rectal vs. colon cancers, and (ii) that neoadjuvant chemoradiotherapy exposure produced a strong shift in CMS subtypes in rectal cancers. We therefore clustered 182 untreated rectal cancers to find rectal cancer-specific subtypes (RSSs).

Results
We identified three robust subtypes. We observed that RSS1 had better, and RSS2 had worse disease-free survival. RSS1 showed high expression of MYC target genes and low activity of angiogenesis genes. RSS2 exhibited low regulatory T cell abundance, strong EMT and angiogenesis signalling, and high activation of TGF-β, NF-κB, and TNF-α signalling. RSS3 was characterised by the deactivation of EGFR, MAPK and WNT pathways.

Conclusions
We conclude that RSS subtyping allows for more accurate prognosis predictions in rectal cancers than CMS subtyping and provides new insight into targetable disease pathways within these subtypes.
Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis
Authors: Middha Pooja , Thummalapalli Rohit , Betti Michael J. , Yao Lydia , Quandt Zoe , Balaratnam Karmugi , Bejan Cosmin A. , Cardenas Eduardo , Falcon Christina J. , Faleck David M. ,   Princess Margaret Lung Group, Leighl Natasha B. , Bradbury Penelope A. , Shepherd Frances A. , Sacher Adrian G. , Eng Lawson , Gubens Matthew A. , Huntsman Scott , Johnson Douglas B. , Kachuri Linda , Khan Khaleeq , Li Min , Lovly Christine M. , Murray Megan H. , Patel Devalben , Werking Kristin , Xu Yaomin , Zhan Luna Jia , Balko Justin M. , Liu Geoffrey , Aldrich Melinda C. , Schoenfeld Adam J. , Ziv Elad 
Published: March 2024

AbstractImmune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn’s disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic risk scores for CD (PRSCD) and UC (PRSUC) in cancer-free individuals and then test these PRSs on IMC in a cohort of 1316 patients with ICI-treated non-small cell lung cancer and perform a replication in 873 ICI-treated pan-cancer patients. In a meta-analysis, the PRSUC predicts all-grade IMC (ORmeta=1.35 per standard deviation [SD], 95% CI = 1.12–1.64, P = 2×10−03) and severe IMC (ORmeta=1.49 per SD, 95% CI = 1.18–1.88, P = 9×10−04). PRSCD is not associated with IMC. Furthermore, PRSUC predicts severe IMC among patients treated with combination ICIs (ORmeta=2.20 per SD, 95% CI = 1.07–4.53, P = 0.03). Overall, PRSUC can identify patients receiving ICI at risk of developing IMC and may be useful to monitor patients and improve patient outcomes.
Direct imaging of magnetohydrodynamic wave mode conversion near a 3D null point on the sun
Authors: Kumar Pankaj , Nakariakov Valery M. , Karpen Judith T. , Cho Kyung-Suk 
Published: March 2024

AbstractMutual conversion of various kinds of magnetohydrodynamic (MHD) waves can have profound impacts on wave propagation, energy transfer, and heating of the solar chromosphere and corona. Mode conversion occurs when an MHD wave travels through a region where the Alfvén and sound speeds are equal (e.g., a 3D magnetic null point). Here we report the direct extreme ultraviolet (EUV) imaging of mode conversion from a fast-mode to a slow-mode MHD wave near a 3D null point using Solar Dynamics Observatory/Atmospheric Imaging Assembly (SDO/AIA) observations. An incident fast EUV wavefront associated with an adjacent eruptive flare propagates laterally through a neighboring pseudostreamer. Shortly after the passage of the fast EUV wave through the null point, a slow-mode wave appears near the null that propagates upward along the open structures and simultaneously downward along the separatrix encompassing the fan loops of the pseudostreamer base. These observations suggest the existence of mode conversion near 3D nulls in the solar corona, as predicted by theory and MHD simulations. Moreover, we observe decaying transverse oscillations in both the open and closed structures of the pseudostreamer, along with quasiperiodic type III radio bursts indicative of repetitive episodes of electron acceleration.