bluuebunny/crossref_metadata_2025_split huggingface dataset:
Butea monosperma seed oil loaded ethosomal vesicular carrier and its hydrogel for vaginal candidiasis: QbD based development, in vitro and in vivo evaluation
Authors: Singh Akriti , Agarwal Shweta , Sourirajan Anuradha , Parashar Arun , Dua Kamal , Chellapan Dinesh Kumar , Singh Sachin Kumar , Gupta Gaurav , Negi Poonam 
Published: March 2024

Abstract

Purpose
Vaginal candidiasis (VC), a common recurrent gynaecological disorder affects almost 70% women. Development of resistance to antifungal agents exacerbates the need for new treatments against Candida infections. The objective of the current work was to develop Ethosomal Vesicles (EVs) and EV hydrogel of Butea monosperma seed oil (BMSO) for treatment of vaginal candidiasis as BMSO has demonstrated fungicidal and bactericidal activity.
Methods
EVs, formulated by ethanol injection-sonication method used Phospholipon90G and ethanol as excipients and were optimized by Box-Behnken design (BBD). BMSO (X1), phospholipid (X2) and ethanol concentration (X3) were selected as input variables, while vesicle size (Y1), PDI (Y2) and %EE (Y3), were taken as response variables.
Results
The size of optimized EVs was found to be 240.9nm, PDI was 0.326, %EE was 53.84%. FESEM and HR-TEM unveiled vesicles of rhombic dodecahedral shape with smooth, sealed structure. The EVs, incorporated into carbopol gel demonstrated non-Newtonian behavior. MIC determination by broth microdilution method revealed MIC of EVs and hydrogel to be 2.5 times less as compared to BMSO against C. albicans. Anti-candidal activities determined using agar well diffusion method demonstrated better zone of inhibition for hydrogel vis-à-vis BMSO. Pharmacodynamic evaluation manifested comparable decrease in fungal burden by EVs and EV hydrogel to marketed Clotrimazole. Histopathology of vaginal tissue of treated groups showed no or mild inflammation with normal skin structure.
Conclusion
The results disclosed EVs and EV hydrogel to possess better antifungal activity vis-a-vis BMSO and can be explored as potential alternative herbal product for VC.
Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia - an EBMT registry analysis of 1540 patients
Authors: Schmid Christoph , Schmaelter Ann-Kristin , Ngoya Maud , Galimard Jacques-Emmanuel , Bazarbachi Ali , Finke Jürgen , Kröger Nicolaus , Bornhauser Martin , Stelljes Matthias , Stölzel Friedrich , Tischer Johanna , Schroeder Thomas , Dreger Peter , Blau Igor-Wolfgang , Savani Bipin , Giebel Sebastian , Esteve Jordi , Arnon Nagler , Ciceri Fabio , Mohty Mohamad 
Published: March 2024

Abstract

Second allogeneic stem cell transplantation (alloSCT2) is among the most effective treatments for acute myeloid leukemia (AML) relapse after first alloSCT (alloSCT1). Long-term EBMT registry data were used to provide large scale, up-to-date outcome results and to identify factors for improved outcome. Among 1540 recipients of alloSCT2, increasing age, better disease control and performance status before alloSCT2, more use of alternative donors and higher conditioning intensity represented important trends over time. Between the first (2000–2004) and last (2015–2019) period, two-year overall and leukemia-free survival (OS/LFS) increased considerably (OS: 22.5%-35%, LFS: 14.5%-24.5%). Cumulative relapse incidence (RI) decreased from 64–50.7%, whereas graft-versus-host disease and non-relapse mortality (NRM) remained unchanged. In multivariable analysis, later period of alloSCT2 was associated with improved OS/LFS (HR = 0.47/0.53) and reduced RI (HR = 0.44). Beyond, remission duration, disease stage and patient performance score were factors for OS, LFS, RI and NRM. Myeloablative conditioning for alloSCT2 decreased RI without increasing NRM, leading to improved OS/LFS. Haploidentical or unrelated donors and older age were associated with higher NRM and inferior OS. In summary, outcome after alloSCT2 has continuously improved over the last two decades despite increasing patient age. The identified factors provide clues for the optimized implementation of alloSCT2.
Strict refinement property of connected loop-free categories
Authors: Ulusoy Aly-Bora , Haucourt Emmanuel 
Published: March 2024

Abstract
In this paper we study the strict refinement property for connected partial orders also known as Hashimoto’s Theorem. This property implies that any isomorphism between products of irreducible structures is determined is uniquely determined as a product of isomorphisms between the factors. This refinement implies a sort of smallest possible decomposition for such structures. After a brief recall of the necessary notion we prove that Hashimoto’s theorem can be extended to connected loop-free categories, i.e. categories with no non-trivial morphisms endomorphisms. A special case of such categories is the category of connected components, for concurrent programs without loops.
MSC Classification: 06A06
Adolescents’ experiences of using patient portals in mental health care - a qualitative study
Authors: Nielsen Martine Stecher , Steinsbekk Aslak , Nøst Torunn Hatlen 
Published: March 2024

Abstract
Background
Adolescents in mental health care are gradually expected to assume greater responsibility for their health care. Patient portals may aid adolescents in this process by providing opportunities for treatment management and easier access to clinical information from their electronic health record (EHR). However, there is limited knowledge of how adolescents in mental health care experience using patient portals. Therefore, the aim of the current study was to explore adolescents´ experiences of using patient portals in mental health care.
Methods
A qualitative study with individual semi-structured interviews with 17 persons who had experiences from using patient portals in child and adolescent specialist mental health care. The main questions concerned how they experienced using a patient portal, how they experienced using different features in the patient portal, and how access had affected their relationship with their healthcare provider.
Results
The data were categorised into three themes: “A tool to assume responsibility”, “To be in control” and “A better understanding vs. negative reactions”. The informants talked about how they had used the patient portal to aid treatment management and that this had helped in their transition into adult care. The feature in the patient portal that the informants talked most about was the access to clinical notes written by healthcare providers. Reading the notes was said to give the informants a better understanding of their condition and helped them to track progress. Still, it could also cause distress and divert attention from their daily activities.
Conclusion
The informants´ experiences with using a patient portal in child and adolescent mental health care varied from managing treatment and getting a better understanding of their situation, to causing distress and challenging the trust in their healthcare providers.
Late fused multi-modal neural network with votingclassifier for Parkinson’s Disease detection
Authors: aljohani Abeer 
Published: March 2024

Abstract
Parkinson’s Disease (PD) is categorized as a neurodegenerative progressivedisease caused by the destruction of the cells in the midbrain posterior.Detecting PD in its early stages will help physicians alleviate the complications of the disease. Artificial Intelligence (AI) is considered as the groupof trained models that can be used for classification and regression. Differentmodalities such as text, speech, and picture, can be used for detecting PD.This research proposes a multi-modal deep learning recognition technique forPD classification. To improve the quality of PD detection in the early stages,the proposed method is composed of three main sections. These sections are:feature extracting, merging, and classifying. As feature extractors a combination of Convolutional Neural Network (CNN) and attention mechanisms isdeveloped. To extract features from related motion signals a combination ofCNN and Long-Short Term Memory (LSTM) model is used. Finally, Random Forest (RF), Logistic Regression (LR), Support Vector Machine (SVM),Extreme Boot Classifier (XGB), and voting classifier are used to distinguishbetween healthy and PD subjects. The experimental result indicates 99.95%accuracy, 99.99% precision, 99.98% sensitivity, and 99.95% F1-score usingthe proposed CNN with attention and voting classifier on PD handwritingand corresponding motion datasets. The achieved results show the proposedmethod of extracting features from both handwriting pictures and correlatedmotor symptoms followed by fusing the features and finally using voting asthe classifier can achieve perfect performance for PD classification
Annexin A11(ANXA 11) facilitates oral squamous cell carcinoma progression via activating the PI3K/AKT signaling pathway
Authors: Xu Ning , Li Jie , Zhang Bi , Zou Sihai , Zhu Luying , He Yungang , Gou Liming , Li Yong 
Published: March 2024

Abstract
Oral squamous cell carcinoma(OSCC) is one of the most frequent malignancies with a high incidence of recurrence and metastasis, accounting for about 90% of the oral and maxillofacial malignant neoplasms. The Annexin A11 (ANXA11) gene has been implicated in various human cancers, with highly expressed ANXA11 reported in the majority of cancers. In the current study, ANXA11 is a highly expressed gene in OSCC patients associated with the TNM stage, degrees of differentiation, and lymph node metastasis. Small interfering RNA verified that ANXA11 accelerated OSCC cell proliferation in vitro by involving the cell cycle and expedited neoplasm growth in vivo. Additionally, the knockdown of ANXA11 effectively suppressed metastasis capacity. Mechanistically, ANXA11 knockdown decreases the phosphorylation of PI3K and AKT, inferring that ANXA11 facilitates OSCC progression via activating the PI3K/AKT signalling pathway in OSCC. In summary, ANXA11, as a novel oncogene, is a potential therapeutic target in OSCC.
VEGF Gene Polymorphism And Study On Genetic Susceptibility Of Neuropsychiatric Lupus
Authors: Yang 阳丽华 , Jin Min , Liu zhiang , Zhou wei , Li Xi , Wang Jian 
Published: March 2024

Abstract
Background: Vascular endothelial growth factor ( VEGF ) plays an important role in the pathogenesis of neuropsychiatric lupus ( NPSLE ), This study was designed for analysis of the relationship between single nucleotide polymorphisms of VEGF gene rs699947, rs10434, rs833070 and genetic susceptibility to NPSLE.
Methods: A total of 82 patients diagnosed as NPSLE and without other autoimmune diseases were selected as the NPSLE group (positive group). Non-NPSLE group (positive control group) 166 patients with systemic lupus erythematosus without psychiatric symptoms. According to the principle of age matching with the positive control group, 150 healthy subjects were randomly selectedas the healthy control group (negative control group). The allele and genotype of three SNP loci and the correlation between NPSLE and non-NPSLE were analyzed.
Results: 1. The genotype frequencies of GG, GA and AA genotypesat rs10434 locus were statistically significant in NPSLE group, non-NPSLE group and negative control group (P < 0.05). 2. The genotype and allele frequencies of rs699947 and rs833070 loci werenot statistically significant in the NPSLE group, non-NPSLE group and negative control group (P > 0.05). 3. rs10434 locus GG genotype and G gene as reference, A allele, mutant heterozygous model GA, dominant model (GA+AA ) were associated with therisk of NPSLE (P < 0.05).
Conclusion: We found that VEGF rs10434 A allele, mutant heterozygous model GA, dominant model GA+AA can increase the risk of NPSLE. A allele and dominant model GA+AA can increase the risk of non-NPSLE. There was no significant correlation between rs699947 and rs833070 polymorphism and the risk of NPSLE and non-NPSLE.
Experimental studies of the three nucleon system dynamics in the proton induced deuteron breakup at 108 MeV
Authors: Łobejko Angelina , Kalantar-Nayestanaki Nasser , Kistryn Stanisław , Kłos Barbara , Kozela Adam , Kulessa Paweł , Parol Wiktor , Skwira-Chalot Izabela , Stephan Elżbieta , Szadziński Albert , Wilczek Andrzej , Włoch Bogusław , Zejma Jacek 
Published: March 2024

Abstract
The differential cross sections for the \(^2\)H(p,pp)n reaction have been measured for more than 80 angular configurations of the outgoing protons in the range of polar angles from 13 to 33 degrees with a proton beam at 108 MeV. Data have been collected at the first experimental run in the Cyclotron Center Bronowice (CCB) at the Institute of Nuclear Physics PAS in Cracow, using the BINA detector setup. Analysis leading to determination of the breakup cross section values is described. Absolute normalization is obtained by normalization to the simultaneously measured \(^1\)H(d,d)p scattering events.Experimental results are compared to the state-of-the-art theoretical calculations. Global analysis shows significant influence of the Coulomb interaction and small effects of three nucleon force in the studied phase space region.
Meson Exchange Currents in the Clothed-particle Representation: Calculation of the Deuteron Magnetic Form Factors
Authors: Kostylenko Yan , Shebeko Oleksandr 
Published: March 2024

Abstract

We show an original way to build up a new family of electromagnetic meson exchange current operators via the method of unitary clothing transformations. Being introduced in such a way they do not depend on the choice of states with which we calculate the matrix elements. The new expressions for meson exchange currents have been compared with ones derived within the previous explorations. Special attention is paid to the deuteron eigenvalue problem and finding the proper deuteron states in a moving frame. An effective technique of ensuring the gauge independence based upon generalization of Siegert’s theorem is proposed. Magnetic form factor of the deuteron is calculated with both one-body and two-body mechanisms. The influence of relativistic effects in the one-body calculation have been considered. Besides, separate contributions from the different meson exchange mechanisms are discussed.
Closure of oroantral fistula using platelet rich fibrin with endoscopic middle meatal antrostomy.
Authors: Elgabarty Amira Tarek , Elmahallay Ahmed Salah , Oraby Mona Samy , Ibraheam Ahmed Aly 
Published: March 2024

Abstract

Background: Oroantral fistula (OAF) is a pathological, epithelialized, and unnatural communication between the maxillary sinus and oral cavity. Recently, functional endoscopic sinus surgery has provided minimally invasive treatment options with fewer postoperative complications. The aim of this study was to evaluate the one stage endoscopic middle meatal antrostomy (EMMA) technique with application of platelet rich fibrin membrane (PRF) for OAF closure and relief of maxillary sinusitis.
Patients and Methods: This study was conducted on nine eligible patients who suffered from OAF with odontogenic sinusitis. A complete excision of the epithelial tract and any necrotic tissue was done with proper curettage. Then, EMMA was performed with simultaneous closure of the OAF by application of PRF membrane and covering it with an acrylic splint. Patients were clinically evaluated for closure of the OAF after 14 days postoperatively, relief of the symptoms, and assessment of the pain level. Also, the size of the bone defect was measured with the aid of computed tomography (CT) preoperatively and after 24 weeks postoperatively.
Results: The patients were seven males and two females with a mean age of 38 years old. Data was collected, tabulated, and statistically analyzed. Healing of the soft tissue wound and bone formation occurred in all patients with relief of maxillary sinusitis without recording any complications. Also, the visual analogue score was statistically significant decreased on the 7th day postoperatively compared with the 1st day postoperatively (p<.001).
Conclusions: One-stage EMMA with the application of a PRF membrane and acrylic splint is a reliable alternative technique for OAF closure and relief of maxillary sinusitis that is associated with lower incidence of complications and minimal postoperative pain level.
Trial registration: The trial had been registered on clinicaltrials.gov (ID: NCT06281873).
Pineal stones have an important function in Alzheimer’s disease
Authors: Ge Wei , Liu Haotian , Pan Meng , Liu Xinnan , Yang Yan , Guo Baohua 
Published: March 2024

Abstract
The pineal gland, an endocrine organ located at the brain's geometric center, primarily secretes melatonin to regulate circadian rhythms. Pineal gland calcification (PGC) is the formation of pineal stones, composed of mainly hydroxyapatite. In vivo study using computed tomography showed patients with Alzheimer’s disease (AD) have significantly higher the degree of PGC than controls. However, the biological function of PGC and its alterations in AD remain unknown. Here we show that PGC is part of a brain filtration system that adsorbs metal ions and has a neuroprotective function. This function is diminished due to decreased carbonate substitution in pineal stones of individuals with AD. We identified four main types of pineal stone by surface micromorpho-elemental analysis, indicating a greater surface morphological diversity in AD. Furthermore, AD pineal stone nanocrystals exhibit neuronotoxicity and promote the formation of soluble amyloid-beta (Aβ)42 oligomers. We propose pineal gland radiomics and serum metallomics as tools for auxiliary diagnosis of AD. We anticipate our assay as an initial step towards advancing basic biological research on PGC and understanding its clinical significance in AD.
Antibiotic prescribing practices and antibiotic use quality indicators in Luang Prabang, Lao PDR : a Point Prevalence Survey in a tertiary care hospital
Authors: Elias Christelle , Ha Nay Thi , Sengvilaipaserth Onanong , Phaychith Athip , Chansamouth Vilada , Phongsavath Valy , Keohavong Bounxou , Detleuxay Khamsay , Maniphone Phaylinh , Soukhaseum Thongphout , Vanhems Philippe , Babin François-Xavier 
Published: March 2024

Abstract
Context
The increase and global dissemination of antibiotic resistance limit the use of antibiotics to prevent and treat infections. Implementing antibiotic stewardship programs guided by local data on prescription profiles is a useful strategy to reduce the burden of antibiotic resistance. The aim was to determine the prevalence of antibiotic use and guideline compliance at Luang Prabang provincial hospital, Lao PDR.
Methods
A point prevalence survey of antibiotics was conducted among hospitalized patients admitted to Luang Prabang hospital (204 beds) in Lao PDR on May 25, 2023. All patients presenting at 8:00 AM were eligible. Sociodemographic data, indications for antibiotic use, and antibiotic prescriptions were collected from medical records using a paper-based questionnaire and entered into an electronic platform following WHO methodology. The prevalence of antibiotic use was determined.
Results
Out of the 102 patients included, 60(58.8%) were undergoing antibiotic treatment, of which 33(55.0%) received combination therapy, and 7(10.5%) had two indications for antibiotic use. The highest prevalence was in the surgical ward (14/15, 93%) followed by general paediatrics (18/27, 67%). Out of the 100 antibiotic prescriptions, 47(47%) were for community-acquired infections, 26(26%) for surgical prophylaxis, 13(13%) for hospital-acquired infections and 5(5%) for medical prophylaxis. Twenty(20%) antibiotics were prescribed for obstetrics and gynaecology prophylaxis, 17(17%) for intra-abdominal infections, and 10(10.0%) for pneumonia treatment as well as bone, and joint infections. The main antibiotics prescribed were ceftriaxone 36(34.6%), metronidazole 18(17.3%), ampicillin 8(7.7%), and gentamicin 8(7.7%). Only 2(3%) samples were sent to the laboratory, one of which showed a positive culture for Escherichia coli Extended Spectrum β-Lactamase. According to the WHO Access Watch and Reserve classification, 55(52.9%) molecules belonged to the Access category, 47(49.1%) to the Watch category, and none to the Reserve category. Only 14.9% of antibiotic prescriptions were fully compliant with current guidelines.
Conclusion
This study indicated a significant prevalence of antibiotic use and a very low compliance with guidelines at Luang Prabang provincial hospital, Lao PDR. This highlights an urgent need for comprehensive strategies at all levels to optimize antibiotic use in hospitals, emphasizing diagnostic improvements, and continued research to address the factors driving this excessive antibiotic usage and improve adherence to guidelines.
Green road to Sustainability: Impact of Urbanization on Environmental Degradation with Infrastructure Investment as Moderator in Belt and Road Initiative Economies
Authors: Suhrab Muhammad , Pinglu Chen , Qian Ningyu 
Published: March 2024

Abstract
This study investigates the effect of urbanization on environmental degradation in economies along the Belt and Road Initiative. Using panel data from 64 BRI countries from 2013 to 2021, the study employs GMM and 2SLS techniques to investigate the linkage between urbanization, infrastructure investment, and environmental degradation. The study found that infrastructure investment has a negative impact on environmental degradation, while urbanization has a significant positive impact on carbon dioxide emissions and rates of deforestation. Furthermore, the study reveals that in BRI economies, infrastructure investment moderates the relationship between urbanization and environmental degradation. This highlights the importance of policies that encourage sustainable development as well as institutions that can efficiently manage the negative effects of urbanization. Policymakers are encouraged by these findings to establish a balance between economic growth and protecting the environment, promote sustainable practices, and promote renewable energy sources. This study closes the knowledge gap on the effects of urbanization on the environment in BRI economies, which promotes the discussion on sustainable development. More research with more participants and a longer period can build on these findings to provide a more thorough understanding of the linkage between environmental deterioration and urbanization in BRI countries.
The impact of Caregiving on the Health and quality of life: A Comparative Population Based study of Caregivers of Elderly Persons in the USA, UK, Canada and Australia
Authors: Patrick Okougbo Odion 
Published: March 2024

Abstract
Caregiving is an important public health issue that affects the health and quality of life of millions of people living in the United States, United Kingdom, Canada, Australia, and the world at large. The caregiver's responsibilities may increase and change as the recipient's needs increase, which can cause additional stress on the caregiver. Therefore, this study examines the impact of caregiving on the health and quality of life of caregivers of older adults in the United States, United Kingdom, Australia, and Canada. The caregiving data presented in this study were collected from studies from the United States of America, United Kingdom, Canada, and Australia. Carers in all 4 countries reported high levels of stress, low levels of health, depression, reduced incomes, difficulty making ends meet, social isolation, loneliness, and absenteeism from work. Caregivers sometimes had to leave the workforce altogether and this led to lower government revenue from income taxes. It is an established fact that a reduction in the workforce of a country often leads to a reduction in government revenue from income taxes. Based on the findings, it was recommended among others that there should be an increase in messaging or information that emphasizes both the important role of caregivers and the importance of maintaining their health and wellbeing.