bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Study of Acupuncture Combined with Alteplase and Tirofiban in the Treatment of Patients with Acute Ischemic Stroke
Authors: Liu Zhen , Peng Zhiyong , Xu Liandeng , Zheng Ping 
Published: April 2024

Background The clinical efficacy of acupuncture combined with alteplase and tirofiban in the treatment of patients with acute ischemic stroke (AIS) was investigated. Methods A total of 130 AIS patients who were treated in our hospital from February 2019 to February 2022 were selected and randomly divided into an observation group with 65 cases and a control group with 65 cases by random number table method. Patients in the control group were treated with conventional treatment and alteplase as well as tirofiban, while those in the observation group were additionally treated with acupuncture on the basis of the control group. The clinical efficacy, National Institute of Health Stoke Scale (NIHSS) and Mini-Mental State Examination (MMSE) scores, and the levels of inflammatory factors as well as vascular endothelial function indexes were compared between the two groups. Results After the treatment, the total effective rate in the observation group was obviously higher than that in the control group (P<0.05). The NIHSS score in the two groups was significantly lower while the MMSE score was evidently increased compared with those before the treatment. The change in the observation group was significantly greater than that in control group (P<0.05). After the treatment, the levels of hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in both groups were distinctly lower than those before the treatment, and the levels in the observation group were evidently lower than those in the control group (P<0.05). Nitric oxide (NO) level in the two groups was obviously increased compared with that before the treatment while endothelin-1 (ET-1) level was remarkably decreased. The change in the observation group was evidently greater than that in the control group (P<0.05). In addition, there were no adverse reactions in the two groups during the treatment. Conclusion Acupuncture combined with alteplase and tirofiban in the treatment of patients with AIS has a significant effect, which can ameliorate symptoms of neurologic impairment, vascular endothelial function and hemorheological status, improve the quality of daily life, and alleviate inflammation in patients. Moreover, it has favorable safety.
"Metaphor-personification" in V.G. Korolenko's Siberian short stories (based on the material of the Yakut cycle)
Authors: Filippova Ayyana Alexsanovna , Basharina Zoya Konstantinovna 
Published: April 2024

The subject of the study is the metaphor-personification involved in the creation of V.G. Korolenko's Siberian short stories. The research material was metaphors-personifications extracted by the continuous sampling method from the stories "Makar's Dream", "Sokolinets", included in the Yakut cycle of Siberian stories. The appeal to the metaphor-personification is justified by the fact that it plays a huge role in the construction of an artistic work. V. Korolenko's stories represent a rich material for research, as he developed his own individual author's metaphors based on impersonation. Metaphorization based on personification is a kind of creative handwriting of Korolenko. His works are rich in artistic means of expression, such as metaphor, personification, comparison, metonymy, hyperbole, which gives him a special original author's style. The methodological and theoretical basis of the research is the work of G.N. Pospelov, A.B. Esin, L.S. Kulik. The work also takes into account the main theoretical works of leading modern Yakut scientists: O.I. Ivanova, K.I. Platonova, I.S. Yemelyanov. Creativity Korolenko is of great interest among modern researchers. Many aspects of his work in literary criticism have already been studied. But in this study, the authors make an attempt to study the functioning of metaphor-personification in his Siberian stories, in particular, in the Siberian stories (Yakut cycle). During the study, it was revealed that V.G. Korolenko skillfully uses the technique of anthropomorphism in his stories. With the help of metaphor, personification and other artistic means of expression, he enlivens and humanizes nature. Korolenko always serves as the personification of the forces of nature to reveal a person’s state of mind, thoughts and feelings. Thanks to metaphor-personification, the world around us comes to life. Thus, the lines between the animate and inanimate world are erased.
Correlation between Postoperative Visual Acuity and Patient-Related Outcomes in Senile Cataract
Authors: Alfin Ruth Jeneral , Alada Joel James 
Published: April 2024

Aims: This study assessed visual function (VF) and quality of life (QOL) post cataract surgery and their relationship with post-operative presenting visual acuity (PVA) in patients operated for senile cataract in two hospitals in Jos, North-central Nigeria.
Study Design: A retrospective, hospital-based, cross-sectional survey.
Place and duration of study: The study took place in the Eye units of the Bingham University Teaching Hospital and the Faith Alive Foundation Hospital both in Jos, North-Central Nigeria between June and August 2021.
Methodology: Patients aged 40 years and above, operated on for senile cataract within 18 months before the onset of the study were included. Sociodemographic data and surgical history were obtained from patients and their surgical records. Visual acuity at presentation was assessed at six weeks or more postoperative period with available correction using Snellen’s acuity and converted to the LogMAR scale. A trained research assistant administered the VF-14 item and QOL-12 item questionnaires and responses were scored using Fletcher’s guidelines. Data was analyzed with STATA version 16.0 using the geometric mean, range, percentages, and Spearman’s rank test.
Results: Eighty-seven (69.6%) participants aged 40-104 years, mean of 67.2 ± 12.0 years with a male-to-female ratio of 1.1:1 were enrolled. Their mean PVA was 0.6LogMAR (6/24) which improved to 0.3LogMAR (6/12). The mean total VF and QOL were 87.1% and 97.5% respectively. Depth perception (99.6%), visual perception, and peripheral vision (94.2% each) scored the highest in the VF subscales. Mental well-being (97.9%) scored the highest in the QOL subscale, followed by social interaction (97.3%). There was a negative correlation between PVA and mean total VF (rs = -0.4, P<0.0001) and QOL (rs = -0.3, P = 0.011).
Conclusion: In this study population, VF and QOL scores improved with increasing PVA.
Mindfulness as a means of reducing aggressive behavior: dispositional and situational evidence
Authors: Heppner Whitney L. , Kernis Michael H. , Lakey Chad E. , Campbell W. Keith , Goldman Brian M. , Davis Patti J. , Cascio Edward V. 
Published: May 2008

AbstractRecent research and theory suggest that mindfulness, or enhanced attention and awareness in the present moment [Brown and Ryan, 2003], may be linked to lower levels of ego‐involvement and, as a result, may have implications for lowering hostility and aggressive behavior. Accordingly, we conducted two studies to examine the potential aggression‐mitigating role of mindfulness. In Study 1, we found that dispositional mindfulness correlated negatively with self‐reported aggressiveness and hostile attribution bias. In Study 2, participants made mindful before receiving social rejection feedback displayed less‐aggressive behavior than did rejected participants not made mindful. Discussion centers on potential mechanisms by which mindfulness operates to reduce aggressive behavior. Aggr. Behav. 34:486–496, 2008. © 2008 Wiley‐Liss, Inc.
Dynamic considerations in the synthesis of self‐optimizing control structures
Authors: Baldea Michael , Araujo Antonio , Skogestad Sigurd , Daoutidis Prodromos 
Published: May 2008

AbstractThis work builds on our prior results to develop novel control structure design principles for integrated plants featuring multiple time scale dynamics. Specifically, the concept of self‐optimizing control can be used to identify the variables that must be controlled to achieve acceptable economic performance during plant operation. This approach does not, however, provide guidelines on control structure design and control loop tuning; a detailed controllability and dynamic analysis is generally needed to this end. In this work, we employ a singular perturbation‐based framework, which accounts for the time scale separation present in the open loop dynamics of integrated plants, to identify the available controlled and manipulated variables in each time scale. The resulting controller design procedure thus accounts for both economic optimality and dynamic performance. The developed concepts are subsequently successfully applied on a reactor‐separator process with recycle and purge. © 2008 American Institute of Chemical Engineers AIChE J, 2008
Bimodal micro‐mesoporous aluminosilicates for heavy oil cracking: Porosity tuning and catalytic properties
Authors: Tan Qingfeng , Fan Yu , Liu Haiyan , Song Tengchun , Shi Gang , Shen Baojian , Bao Xiaojun 
Published: May 2008

AbstractThrough a two‐step synthesis procedure, bimodal micro‐mesoporous aluminosilicates, denoted as B‐MASs, were synthesized by assembling preformed zeolite Y nanoclusters using a triblock polymer as template. By controlling the aging conditions of preformed zeolite nanoclusters the porosity of the B‐MASs was suitably tuned. The characterization results showed that the pore walls of the mesoporous phase in theB‐MASs consist of zeolite Y nanoclusters and the microporosity of the B‐MASs is inherited from the incorporated nanoclusters. It was suggested that more incorporation of the well‐developed zeolite nanoclusters accounts for the increasing microporosity of the B‐MASs with the increasing aging temperature of the preformed zeolite nanoclusters. The incorporated nanoclusters have much shorter pore channels and mainly contribute weak Lewis acid sites to the B‐MASs. The resulting bimodal micro‐mesoporous materials B‐MASs with mutually connected mesopores and shorter micropores showed superior catalytic properties when used for cracking heavy crude oil. © 2008 American Institute of Chemical Engineers AIChE J, 2008
In situ gel forming systems of poloxamer 407 and hydroxypropyl cellulose or hydroxypropyl methyl cellulose mixtures for controlled delivery of vancomycin
Authors: Talasaz Azita H. H. , Ghahremankhani Ali A. , Moghadam Shadi H. , Malekshahi Mazda R. , Atyabi Fatemeh , Dinarvand Rassoul 
Published: May 2008

AbstractPoloxamers are a family of triblock copolymers consisting of two hydrophilic blocks of polyoxyethylene separated by a hydrophobic block of polyoxypropylene, which form micelles at low concentrations and form clear thermally reversible gels at high concentrations. The objective of this study was to develop an in situ gel forming drug delivery system for vancomycin using the minimum possible ratio of poloxamer 407 (P407). Decreasing the concentration of poloxamer could reduce the risk of hypertriglyceridemia induction. Different additives were added to the poloxamer formulations. It was observed that among different additives, hydroxypropyl methyl cellulose (HPMC) and hydroxypropyl cellulose (HPC) can decrease poloxamer concentration required to form in situ gelation from 18 to 10%. The dynamic viscoelastic properties of the samples were determined. Both the storage modulus and the loss modulus of the samples increased abruptly as the temperature passed a certain point. The gelling temperature was in the order of P407 : HPC (10 : 10 w/w) < P407 : HPMC (10 : 10 w/w) < P407 : HPMC (15 : 5 w/w) < P407 : HPC (15 : 5 w/w). Drug release rate could be controlled by changing the type and ratio of additives as well as the amount of drug loaded. It can be concluded that combining P407 and cellulose derivatives could be a promising strategy for preparation of thermally reversible in situ gel forming delivery systems with low poloxamer concentration. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Nanoelectrocatalyst Based on High‐Density Au/Pt Hybrid Nanoparticles Supported on a Silica Nanosphere
Authors: Guo Shaojun , Zhai Junfeng , Fang Youxing , Dong Shaojun , Wang Erkang 
Published: May 2008

AbstractA high‐efficiency nanoelectrocatalyst based on high‐density Au/Pt hybrid nanoparticles supported on a silica nanosphere (Au‐Pt/SiO2) has been prepared by a facile wet chemical method. Scanning electron microscopy, transmission electron microscopy, energy‐dispersive X‐ray spectroscopy, and X‐ray photoelectron spectroscopy are employed to characterize the obtained Au‐Pt/SiO2. It was found that each hybrid nanosphere is composed of high‐density small Au/Pt hybrid nanoparticles with rough surfaces. These small Au/Pt hybrid nanoparticles interconnect and form a porous nanostructure, which provides highly accessible activity sites, as required for high electrocatalytic activity. We suggest that the particular morphology of the Au‐Pt/SiO2 may be the reason for the high catalytic activity. Thus, this hybrid nanomaterial may find a potential application in fuel cells.
Maximizing the liquid fuel yield in a biorefining process
Authors: Zhang Bo , von Keitz Marc , Valentas Kenneth 
Published: May 2008

AbstractBiorefining strives to recover the maximum value from each fraction, at minimum energy cost. In order to seek an unbiased and thorough assessment of the alleged opportunity offered by biomass fuels, the direct conversion of various lignocellulosic biomass was studied: aspen pulp wood (Populus tremuloides), aspen wood pretreated with dilute acid, aspen lignin, aspen logging residues, corn stalk, corn spathe, corn cob, corn stover, corn stover pellet, corn stover pretreated with dilute acid, and lignin extracted from corn stover. Besides the heating rate, the yield of liquid products was found to be dependent on the final liquefaction temperature and the length of liquefaction time. The major compounds of the liquid products from various origins were identified by GC–MS. The lignin was found to be a good candidate for the liquefaction process, and biomass fractionation was necessary to maximize the yield of the liquid bio‐fuel. The results suggest a biorefinery process accompanying pretreatment, fermentation to ethanol, liquefaction to bio‐crude oil, and other thermo‐conversion technologies, such as gasification. Other biorefinery options, including supercritical water gasification and the effectual utilization of the bio‐crude oil, are also addressed. © 2008 Wiley Periodicals, Inc.
Manufacture of stable palladium and gold nanoparticles on native and genetically engineered flagella scaffolds
Authors: Deplanche Kevin , Woods Richard D. , Mikheenko Iryna P. , Sockett R. Elizabeth , Macaskie Lynne E. 
Published: May 2008

AbstractThe use of bacterial flagella as templates for the immobilization of Pd and Au nanoparticles is described. Complete coverage of D. desulfuricans flagellar filaments by Pd(0) nanoparticles was obtained via the H2‐mediated reduction of [Pd(NH3)4]Cl2 but similar results were not obtained using HAuCl4. The introduction of additional cysteine‐derived thiol residues in the E. coli FliC protein increased Au(III) sorption and reduction onto the surface of the flagellar filament and resulted in the production of stabilized Au(0) nanoparticles of ∼20–50 nm diameter. We demonstrate the application of molecular engineering techniques to manufacture biologically passivated Au(0) nanoparticles of a size suitable for catalytic applications. Biotechnol. Bioeng. © 2008 Wiley Periodicals, Inc.
Substrate‐Induced Stable Enzyme–Inhibitor Complex Formation Allows Tight Binding of Novel 2‐Aminopyrimidin‐4(3H)‐ones to Drug‐Resistant HIV‐1 Reverse Transcriptase Mutants
Authors: Samuele Alberta , Facchini Marcella , Rotili Dante , Mai Antonello , Artico Marino , Armand‐Ugón Mercedes , Esté José A. , Maga Giovanni 
Published: May 2008

AbstractWe recently reported the synthesis and biological evaluation of a novel series of 5‐alkyl‐2‐(N,N‐disubstituted)amino‐6‐(2,6‐difluorophenylalkyl)‐3,4‐dihydropyrimidin‐4(3 H)‐ones (F2‐N,N‐DABOs). These compounds are highly active against both wild‐type HIV‐1 and the K103N, Y181C, and Y188L mutant strains. Herein we present novel 6‐(2‐chloro‐6‐fluorophenylalkyl)‐N,N‐DABO (2‐Cl‐6‐F‐N,N‐DABO) derivatives and investigate the molecular basis for their high‐affinity binding to HIV‐1 reverse transcriptase (RT). Our results show that the new compounds display higher association rates than the difluoro derivatives toward wild‐type HIV‐1 RT or drug‐resistant RT mutant forms. We also show that they preferentially associate to either the free enzyme or the enzyme–nucleic acid binary complex, and that this binding is stabilized upon formation of the ternary complex between HIV‐1 RT and both the nucleic acid and nucleotide substrates. Interestingly, one compound showed dissociation rates from the ternary complex with RT mutants K103N and Y181I 10–20‐fold slower than from the corresponding complex with wild‐type RT.
Expression of the basal cell markers of taste buds in the anterior tongue and soft palate of the mouse embryo
Authors: Nakayama Ayumi , Miura Hirohito , Shindo Yoichiro , Kusakabe Yuko , Tomonari Hiroshi , Harada Shuitsu 
Published: May 2008

AbstractAlthough embryonic expression of Shh in the fungiform papilla placodes has a critical role in fungiform papilla patterning, it remains unclear whether its appearance indicates the differentiation of the basal cells of taste buds. To examine the embryonic development of the basal cells, the expression of Shh, Prox1, and Mash1 was determined in the anterior tongue and soft palate in mouse embryos by in situ hybridization. In the anterior tongue, Prox1 was coexpressed with Shh from the beginning of Shh expression in the fungiform papilla placodes at E12.5. Shh was expressed in the soft palate in a band‐like pattern in the anteriormost region and in a punctate pattern in the posterior region at E14.5. The number (21.4 ± 4.3, at E14.5) of locations where Shh was observed (i.e., spots) rapidly increased and reached a peak level (54.8 ± 4.0 at E15.5). Also in the soft palate, Prox1 was coexpressed with Shh from the beginning of Shh expression. These results suggest that basal cell differentiation occurs synchronously with the patterning of Shh spots both in the anterior tongue and in the soft palate. In contrast, Mash1 expression lagged behind the expression of Shh and Prox1 and began after the number of Shh spots had reached its peak level in the soft palate. Furthermore, immunohistochemistry of PGP9.5 and Shh revealed that epithelial innervation slightly preceded Mash1 expression both in the tongue and in the soft palate. This is the first report describing the time courses of the embryonic expression of basal cell markers of taste buds. J. Comp. Neurol. 509:211–224, 2008. © 2008 Wiley‐Liss, Inc.
Integrin β1 is involved in the signaling of glial cell line‐derived neurotrophic factor
Authors: Cao Jun‐Ping , Yu Jing‐Kao , Li Chong , Sun Yu , Yuan Hong‐Hua , Wang Hong‐Jun , Gao Dian‐Shuai 
Published: May 2008

AbstractGlial cell line‐derived neurotrophic factor (GDNF) is a potent neurotrophic factor for the substantia nigra (SN) dopamine (DA) neurons. The transmembrane signaling of GDNF is mediated by a unique receptor system, including the ligand binding receptor GDNF family receptor α (GFRα) and the transmembrane signaling receptor Ret or neural cell adhesion molecule‐140 (NCAM‐140). Here, we found that another transmembrane cell adhesion molecule, integrin, a heterodimer consisting of α and β subunits, also mediates the transmembrane signaling of GDNF. The results showed that the level of phosphorylated Src homology 2 domain containing (Shc), which was associated with the cytoplasmic domain of integrin β1, increased after GDNF administration. Coimmunoprecipitation analysis demonstrated that integrin β1 could form a complex with GFRαl. The simulation of molecular modeling showed that four H‐bonds were formed between integrin β1 and GFRα. These data indicate that integrin β1 is involved in the transmembrane signaling of GDNF and suggest that integrin β1 may be an alternative signaling receptor for GDNF. J. Comp. Neurol. 509:203–210, 2008. © 2008 Wiley‐Liss, Inc.
Growth and characterization of a new potential second harmonic generation material from the amino acid family: L‐Valinium picrate
Authors: Martin Britto Dhas S. A. , Natarajan S. 
Published: May 2008

AbstractL‐Valinium picrate (C5H12NO2)+. (C6H2N3O7)–, a non‐linear optical material from the amino acid family which has large second harmonic generation (SHG) efficiency, was grown by slow evaporation method. Characterization of the crystals was made using single crystal X‐ray diffraction. The functional groups and the modes of vibrations were found by using the Fourier transform infrared (FTIR) spectroscopy. The second harmonic generation (SHG) conversion efficiency was investigated using the Kurtz and Perry method. The SHG conversion efficiency is 60 times higher than that of the standard KDP and 8 times higher than that of the standard Urea and the optical transparency was analyzed using UV‐visible‐NIR absorption spectrum. The structural features of the material leading to the large SHG efficiency are discussed. Microhardness and dielectric studies were also carried out. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Crystal structure of the quaternary alloy CuTaInSe3
Authors: Delgado G. E. , Mora A. J. , Grima‐Gallardo P. , Durán S. , Muñoz M. , Quintero M. 
Published: May 2008

AbstractThe crystal structure of the quaternary compound CuTaInSe3 belonging to the system (CuInSe2)1‐x(TaSe)x with x= 0.5, was analyzed using X‐ray powder diffraction data. This material is isostructural with the CuFeInSe3 compound, and crystallize in the tetragonal space group P42c (Nº 112), Z = 1, with unit cell parameters a = 5.7831(1) Å, c = 11.6227(4) Å, V = 388.71(2) Å3. The Rietveld refinement of 18 instrumental and structural variables led to Rp = 8.0%, Rwp = 9.5%, Rexp = 6.3% and χ2 = 1.5 for 4501 step intensities and 144 independent reflections. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Temperature dependence of growth orientation and surface morphology of Li‐doped ZnO thin films on SiO2/Si substrates
Authors: El‐Maghraby E. M. 
Published: May 2008

AbstractZnO thin films doped with Li (ZnO:Li) were deposited onto SiO2/Si (100) substrates by direct‐current sputtering technique in the temperature range from room temperature to 500 °C. The crystalline structure, surface morphology and composition, and optical reflectivity of the deposited films were studied by X‐ray diffraction (XRD), Scanning Electron Microscopy (SEM), X‐ray Photoelectron Spectroscopy (XPS) and optical reflection measurements. Rough surface p‐type ZnO thin film deposition was confirmed. The results indicated that the ZnO:Li films growed at low temperatures show c‐axis orientation, while a‐axis growth direction is preferable at high temperatures. Moreover, the optical reflectivity from the surface of the films matched very well with the obtained results. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)