bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible role of endoplasmic reticulum stress in the pathogenesis of chronic adenoiditis and adenoid hypertrophy: A prospective, parallel‐group study
Authors: Onal Merih , Elsurer Cagdas , Duran Tugce , Kocak Nadir , Ulusoy Bulent , Bozkurt Mete Kaan , Onal Ozkan 
Published: April 2024

AbstractBackgroundAdenoid tissue is a first‐line host defense secondary lymphoid organ, especially in childhood. The endoplasmic reticulum (ER) is required to maintain balanced cellular activity. With impaired ER functions, protein accumulation occurs, resulting in ER stress, which plays a role in the etiopathogenesis of many diseases.ObjectiveWe aimed to investigate the relationship between ER stress and adenoid tissue disorders, thereby elucidating the mechanisms of immunity‐related diseases.MethodsFifty‐four pediatric patients (>3 years old) who underwent adenoidectomy for chronic adenoiditis (CA) or adenoid hypertrophy (AH) were enrolled in this prospective, parallel‐group clinical study. Adenoids were divided into two groups (CA or AH) based on their size and evaluated for ER stress pathway and apoptosis pathway markers by Real‐time PCR and Western blot analysis.ResultsER stress pathway markers significantly differed between the CA and AH groups. Children with CA had higher ER stress marker levels than the AH group (p < .001 for ATF‐4, ATF‐6, and GRP78, and p < .05 for EDEM1, CHOP, EIF2AK3, ERNI, and GRP94). Apoptosis pathway marker levels (BAX and BCL‐2) were not different between groups.ConclusionsER stress contributes to the etiopathogenesis of adenoid tissue diseases and the pathogenesis of adenoid tissue disorders, which are part of the immune response. These results may guide the development of new and alternative treatments for immune system disorders.
Monodisperse Polyaspartic Acid Derivative Microspheres for Potential Tumor Embolization Therapy
Authors: Xu Anqi , Sun Yuchen , Guo Mingyu 
Published: April 2024

AbstractPolyaspartic acid derivatives are a well‐known kind of polypeptide with good biocompatibility and biodegradability, and thus have been widely used as biomedical materials, including drug‐loaded nano‐scale micelles or macroscopic hydrogels. In this work, for the first time, monodisperse polyaspartic acid derivative microspheres with diameter ranging from 120 to 350 µm for potential tumor embolization therapy are successfully prepared by single emulsion droplet microfluidic technique. The obtained microsphere shows fast cationic anticancer drug doxorubicin hydrochloride loading kinetics with high loading capacity, which is much better than those of the commercial ones. Additionally, drug release behaviors of the drug‐loaded microspheres with different diameters in different media are also studied and discussed in detail. These results provide some new insights for the preparation and potential application of polyaspartic acid derivative‐based monodisperse microspheres, especially for their potential application as embolic agent.
Joint promotional effort and assortment optimization under the multinomial logit model
Authors: Xiao Hua , Gong Min , Lian Zhaotong , Nip Kameng 
Published: April 2024

AbstractPromotional effort is a common strategy to induce sales and broaden the market scope by enhancing the products' utility to customers. In this article, we incorporate promotional effort into the customer choice model and study the joint promotional effort and assortment optimization problems, where the customer's choice behavior follows the widely used multinomial‐logit (MNL) model. Motivated by various marketing scenarios, we introduce two distinct models that address the allocation of promotional effort: (1) differentiated promotional effort—the retailer can arbitrarily allocate promotional resources to each offered product; (2) uniform promotional effort—the retailer can determine a promotional level, and the promotional effort is equally distributed to each offered product. In the first model, the revenue‐ordered assortment strategy is optimal, and we can efficiently determine the optimal promotional effort level. In the second model, the revenue‐ordered assortment is no longer optimal. We develop a polynomial time algorithm to solve the joint optimization problem under this model. Using the algorithmic results, we conduct comparative analyses between the assortment optimization problem under the proposed models and the classic MNL model, which does not exert any promotional effort. We show that the assortment size shrinks when the retailer makes the promotional effort in the decision, which indicates that product variety and promotional effort are strategic substitutes. Moreover, the retailer and customers can be better off in the presence of promotional efforts, irrespective of the format. Additionally, we conduct extensive numerical experiments to demonstrate our analytical results and gain more managerial insights.
Emergence of imaging technology beyond the clinical setting: Utilization of mobile health tools for at‐home testing
Authors: Starkoff Brooke E. , Nickerson Brett S. 
Published: April 2024

AbstractBody composition assessment plays a pivotal role in understanding health, disease risk, and treatment efficacy. This narrative review explores two primary aspects: imaging techniques, namely ultrasound (US) and dual‐energy x‐ray absorptiometry (DXA), and the emergence of artificial intelligence (AI) and mobile health apps in telehealth for body composition. Although US is valuable for assessing subcutaneous fat and muscle thickness, DXA accurately quantifies bone mineral content, fat mass, and lean mass. Despite their effectiveness, accessibility and cost remain barriers to widespread adoption. The integration of AI‐powered image analysis may help explain tissue differentiation, whereas mobile health apps offer real‐time metabolic monitoring and personalized feedback. New apps such as MeThreeSixty and Made Health and Fitness offer the advantages of clinic‐based imaging techniques from the comfort of home. These innovations hold the potential for individualizing strategies and interventions, optimizing clinical outcomes, and empowering informed decision‐making for both healthcare professionals and patients/clients. Navigating the intricacies of these emerging tools, critically assessing their validity and reliability, and ensuring inclusivity across diverse populations and conditions will be crucial in harnessing their full potential. By integrating advancements in body composition assessment, healthcare can move beyond the limitations of traditional methods and deliver truly personalized, data‐driven care to optimize well‐being.
Data sharing mode of dispatching automation system based on distributed machine learning
Authors: He Xiaoli , Luo Mi , Hu Yurui , Xiong Feng 
Published: April 2024

AbstractThe difficulties of sending massive amounts of data between several data centres are examined in this work, with particular attention paid to how poorly current scheduling algorithms handle point‐to‐multipoint transfers and transmission time limits. In this research, a new method called multicast source‐based tree (MSBT) is proposed for effectively handling point‐to‐multipoint transmissions in a certain amount of time. By allowing receivers to simultaneously receive data from several source points, MSBT introduces the idea of ‘source selection’ for the creation of multicast tree structure‐based algorithms. Large data blocks are distributed as efficiently as possible using this method, which also guarantees effective transmission from a single‐source point to several recipient locations. Furthermore covered in the article is how PV producers and sellers' capacity allocation is affected by the discount rate. These results offer insightful information on how decisions are made in related sectors. The development of new energy big data platforms underscores their significance; leaders in the industry, like United Power, Vision Energy and Goldwind, serve as prime examples.
Impact of BMI on Dyspnea and Need for Surgical Intervention in Bilateral Vocal Fold Immobility
Authors: Elsamna Samer T. , Lin Matthew E. , Smith Teagen , Johns Michael , Rutt Amy , Bensoussan Yael 
Published: April 2024

AbstractObjectiveBilateral vocal fold paralysis (BVFP) and posterior glottic stenosis (PGS) are causes of bilateral vocal fold immobility (BVFI) and may cause shortness of breath, stridor, and need for surgical intervention. Although increased body mass index (BMI) is associated with restrictive breathing patterns in patients with normal upper airways, it is unclear how BMI impacts dyspnea and need for surgical intervention in BVFI patients.Study DesignRetrospective cohort study.SettingThree tertiary academic centers in the United States.MethodsDemographics, BMI, Dyspnea Index (DI), etiology, presence of tracheostomy and surgical intervention (dilation, tracheostomy, cordotomy, arytenoidectomy, open reconstruction) were collected. Primary outcomes included dyspnea measured by DI and need for surgery to improve airway. Linear regressions were performed to assess continuous outcomes. Mann‐Whitney U‐test was utilized to assess categorical outcomes.ResultsAmong 121 patients, 52 presented with BVFP and 69 with PGS. Previous neck surgery was the most common cause of BVFI (40.2%). 44.3% of patients received a tracheostomy. Through multivariate linear regression, increased BMI was significantly associated with increased DI in the entire cohort (β = .43, P = .016). Increased BMI was also associated with need for any surgical intervention (odds ratio [OR] = 1.07, 95% confidence interval [CI] = [1.01‐1.13]) in the overall cohort. When stratifying our data, BMI was only significantly associated with DI in BVFP (β = .496) and need for surgical intervention in PGS (OR = 1.11, 95% CI = [1.01‐1.21]), although a positive trend was seen in all analyses.ConclusionIncreased BMI may correlate with worsening dyspnea symptoms and need for surgical intervention in patients with BVFI. Weight‐loss‐related counseling may benefit symptom management.
From morphology to methylome: epigenetic studies of Müllerian mesonephric‐like adenocarcinoma reveal similarities to cervical mesonephric adenocarcinoma†
Authors: Lin Lawrence H , Howitt Brooke E , Kolin David L 
Published: April 2024

AbstractMesonephric adenocarcinomas (MAs) and mesonephric‐like adenocarcinomas (MLAs) are rare, aggressive neoplasms that arise in the gynecologic tract and show overlapping morphologic, immunohistochemical, and molecular features. While MAs occur in the cervix and are thought to arise from mesonephric remnants, MLAs occur in the endometrium and ovary and are believed to originate from transdifferentiation of Müllerian lesions. Both MAs and MLAs show a variety of architectural patterns, exhibit frequent expression of GATA3 by immunohistochemistry, and harbor KRAS mutations. In a recent article published in The Journal of Pathology, Kommoss and colleagues used DNA methylation profiling to extend these similarities and showed that MLAs and MAs cluster together based on their epigenetic signatures and are epigenetically distinct from other Müllerian adenocarcinomas. They also showed that MLAs and MAs harbor a high number of global copy number alterations. This study provides evidence that MLAs more closely resemble MAs than Müllerian carcinomas on an epigenetic level. As a result, the authors argue that MLA should be renamed ‘mesonephric‐type adenocarcinoma.’ Further research is needed to establish the relationship between these two entities, their etiology, and pathogenesis. © 2024 The Pathological Society of Great Britain and Ireland.
Peppermint oil‐infused polylactic acid films: A novel approach for antimicrobial and biodegradable food packaging
Authors: Emir Ayca Aydogdu , Yildiz Eda , Kirtil Emrah 
Published: April 2024

AbstractExtensive research is currently dedicated to creating biodegradable packaging materials that match the qualities of traditional synthetic packaging materials. Among these options, polylactic acid (PLA) is noteworthy. PLA is a renewable‐source‐derived thermoplastic polymer with excellent barrier properties, mechanical strength, and a strong safety profile. To enhance food product shelf life, active packaging materials, incorporating functional ingredients like antimicrobials, have gained prominence. Peppermint essential oil is one such active ingredient, offering potential improvements in preserving food freshness and safety. This study's objective is to craft antimicrobial, biodegradable food packaging materials by blending peppermint oil into PLA films. Various peppermint oil concentrations (1.25%, 1.875%, and 2.5% w/v) were blended with PLA to assess their impact on opacity, water vapor permeability (WVP), mechanical and thermal properties, and antimicrobial characteristics. Higher peppermint oil concentrations increased opacity, making them advantageous for light‐sensitive food items. These films reduced WVP without affecting PLA's thermal stability. Antimicrobial effectiveness was evaluated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), showing inhibition with 1.875% and 2.5% w/v peppermint oil concentrations. Compared to control, PLA films with peppermint oil extended the shelf life of packaged chicken breast meats from 3 to 8 days. As a result, incorporating peppermint oil into PLA films presents a promising solution for advanced antimicrobial and biodegradable food packaging.Highlights
The incorporation of peppermint oil resulted in higher opacity values.
Peppermint incorporated PLA films showed antimicrobial activity.
Peppermint oil addition decreased water vapor permeability of PLA films.
Peppermint oil added PLA films increased the shelf life of chicken meat up to 8 days.
Large‐scale breeding applications of unoccupied aircraft systems enabled genomic prediction
Authors: Herr Andrew W. , Schmuker Peter , Carter Arron H. 
Published: April 2024

AbstractBreeding for improved, reliable cultivars despite growing environmental irregularity can be challenging. Unoccupied aircraft systems (UAS) are a popular high‐throughput phenotyping technology that has been shown to help interpret the mechanisms associated with crop productivity and environmental response, creating potential for improved breeding strategies. Spectral reflectance indices (SRIs), encompassing both vegetation and water indices like normalized difference vegetation index (NDVI), normalized difference red‐edge index, and normalized water index, were employed to assess 4094 winter wheat genotypes across 11,593 breeding plots at Washington State University from 2019 through 2022. SRIs were then used with genomic data in univariate models as covariates and multivariate models as secondary response variables for predictions of grain yield. The prediction accuracy of models was evaluated using a leave‐one‐year‐out validation strategy against a base genomic prediction method. Including SRI data as fixed effects in univariate genomic prediction models can improve prediction accuracy over the control but is unreliable across years. When used in multivariate models, SRIs improve prediction performance across years but require high‐performance computational resources that could limit feasibility. In univariate models, when test year NDVI data were available and used to calculate breeding values, prediction performance was at least 16% better than the control, ranging in prediction accuracy from 0.54 in 2019 to 0.93 in 2020. This study highlights the limited reliability of SRI use in genomic prediction of untested environments and locations. However, a significant application for the technology can be found in early‐season UAS data collection to aid accurate predictions in late season, a helpful tool in tight turnaround times commonly experienced in winter crop breeding programs.
DFT study of the half‐metallic variant perovskites A2OsX6 (A = Rb/Cs; X = Cl/Br) for spintronic and thermoelectric applications
Authors: Ullah Rehan , Faizan Muhammad , Khan Shah Haidar 
Published: April 2024

AbstractWe present our results of the spin‐polarized calculations on the structural, magneto‐electronic, thermodynamic, and thermoelectric properties of vacancy‐ordered double perovskites A2OsX6 (A = Rb/Cs; X = Cl/Br). We utilized the Wu‐Cohen generalized gradient approximation (Wu‐GGA) and the mBJ scheme to determine a more reliable electronic structure. The compounds exhibit negative formation energy, suitable tolerance factor, and a stable phonon spectrum, indicating their stability. The compounds show half‐metallicity, acting as semiconductors with direct band gaps between 2 and 3 eV in the spin‐up orientation while metallic in the spin‐down. Each compound shows a total spin magnetic moment of 2.00 μB per formula unit, with Os‐t2g states contributing the most (~1.5 μB). The computed thermoelectric coefficient indicates the usability of these compounds across a wide temperature range (200–800 K) with high electrical conductivity and low electronic thermal conductivity. The compounds exhibit high Seebeck coefficient and figure of merit (ZT), making them suitable for thermoelectric applications. With ferromagnetic and half‐metallic characteristics, these compounds could be promising candidates for spintronics, thermoelectronic, and data storage applications.
UAV‐based simultaneous localization and mapping in outdoor environments: A systematic scoping review
Authors: Wang Kaiwen , Kooistra Lammmert , Pan Ruoxi , Wang Wensheng , Valente João 
Published: April 2024

AbstractThis study aims to investigate the current knowledge of unmanned aerial vehicle (UAV)‐based simultaneous localization and mapping (SLAM) in outdoor environments and to discuss challenges and limitations in this field. A literature search was conducted in three online databases (Web of Science, Scopus, and IEEE) for articles published before October 2022 related to UAV‐based SLAM. A scoping review was carried out to identify the key concepts and applications, and discover research gaps in the use of algorithm‐oriented and task‐oriented, open‐source studies. A total of 97 studies met the criteria after conducting a two‐step screening by a systematic method followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Among eligible studies, 97 were classified into two main categories: algorithm‐oriented studies and task‐oriented studies. The analysis of the literature revealed that the majority of the studies were focused on the development and implementation of new algorithms and algorithms. This review highlights the significance and diversity of sensors utilized in UAVs in different tasks and applications scenarios that employ different types of sensors. The evaluation method is able to show the real results and performance of the new algorithms in the target scenarios compared with the evaluation method by the public data set and simulation platform.
Tuning the A‐site Element in LaCo0.8Fe0.2O3 Perovskite‐based Catalyst for High Temperature N2O Decomposition in Nitric Acid Plant
Authors: Zheng Peng , He Faquan , Wu Yihao , Yang Jianhui , Jing Fangli , Granger Pascal 
Published: April 2024

AbstractThe effect of La‐deficiency and Ce/Sr‐substitution in the benchmark LaCo0.8Fe0.2O3 has been investigated for the decomposition of N2O between 500 and 900 °C. Real inlet gas composition and space velocity reveal that La‐deficiency and Ce/Sr‐substitution can improve the thermal stability of catalyst, while La1‐xSrxCo0.8Fe0.2O3 with x≥0.1 was highlighted as a promising formula due to the strongest resistance to deactivation and suppressed undesired NOx decomposition at high space velocity. This phenomenon is mainly ascribed to the incorporation of Sr2+ into the perovskite lattice during the reaction consequently stabilizing the Co3+ species and creating the oxygen vacancies in La1‐xSrxCoO3‐δ. On the contrary, the loss of activity on Ce‐substituted LaCo0.8Fe0.2O3 has been preferentially related to the cobalt exsolution to extra framework of perovskite making the catalytic cycle with Co3+ unfavorable. All these bulk and surface changes are accompanied with opposite evolution of apparent activation energy and pre‐exponential factor which can be discussed based on a redox mechanism.
Influence of Substituents on the Reaction of Substituted (4‐Oxo‐3‐Phenyl‐1,3‐Thiazolidin‐2‐Ylidene)acetates with α,α‐Dicyanoolefins: Synthesis of Quinoline and Quinazoline‐Substituted Carboxylates
Authors: Alizadeh Abdolali , Rostampoor Azar 
Published: April 2024

AbstractIn this work, a novel strategy for the straightforward synthesis of quinoline and quinazoline‐substituted carboxylates is described. The reaction between substituted (4‐oxo‐3‐phenyl‐1,3‐thiazolidin‐2‐ylidene)acetates and substituted α,α‐dicyanoolefins is explored, with a focus on the effects of substituents. The process involves a base‐mediated Michael addition, cleavage of C−C bonds, intramolecular cyclization, [1,5]‐H shift, and aromatization. The benefits of this process include high efficiency, mild reaction conditions, simplicity, and a wide range of products. To the best of our knowledge, there are no previous reports for the synthesis of these classes of quinoline and quinazoline‐substituted carboxylate derivatives.
Influence of Complex Plasticizer on Plasticizing Effects and Rheological Properties of Plasticized Poly(Vinyl Alcohol)
Authors: Wang Chao , Zou Liming , Wang Huajun , Wang Yanli , Li Yan Vivian 
Published: April 2024

AbstractPoly(vinyl alcohol) (PVA) was modified using D‐mannitol (DM) and 1‐butyl‐3‐methylimidazole bromide (BMIMBr) as the complex plasticizer (DB), and PVA/DB composite was prepared. The plasticizing effect of DB on PVA was studied by Fourier transform infrared spectroscopy (FT‐IR), differntial scanning calorimetry (DSC), thermos gravimetric analysis (TGA) and melt flow indexer (MI). FT‐IR analysis indicated that Br− of BMIMBr and OH of DM could form H‐bonds with OH of PVA. With the increase of DB, the melt temperature (Tm2) and crystallization temperature (Tc1) of PVA/DB composite decreased, the initial thermal decomposition temperatures (Td), thermal processing window (ΔT) and MI values increased respectively. Based on above studies, the influence of DB content on rheological properties of PVA/DB composite was investigated by the capillary rheometer. The result displayed that apparent viscosity of PVA/DB composite decreased with increasing DB content, shear rate and measured temperature. The non‐Newtonian index (n) increased and structural viscosity index (Δη) decreased with the increase of measured temperature and DB. The viscous flow activation energy (Eη) decreased as the shear rate and DB content increased. When the measured temperature, DB content and shear rate were in the range of Tm2+30 −Tm2+35 °C, 40–50 wt% and 764.8–1504.9 s−1, respectively, the spinnability of PVA/DB composite was optimal, which will lay a theoretical foundation for the exploration of melt spinning process in the future.
Oxygen Vacancies Boost High‐Energy {100} Faceted TiO2 for Efficient Photocatalytic Degradation of Rhodamine B
Authors: Ma Xiaojia , Tang Xuejing , Yi Hui , Cai Jinyuan , Guo Sheng‐Qi 
Published: April 2024

AbstractPhotocatalytic reaction takes place on the surface of the catalyst, the crystal plane engineering which can adjust and optimize the surface atomic ordering and electronic energy band structure has been widely studied, considering the microchemical environment changes caused by defects on different surfaces, the combination of crystal plane engineering and defect engineering is expected to become a promising strategy to greatly improve the performance of photocatalysis. In this paper, we introduce 2,2’‐Bipyridyl to induce oxygen vacancy in the synthesis of highly exposed {100} faceted TiO2 nanorods, and obtain oxygen‐rich TiO2 nanomaterials. Benefit from the synergistic effect of high‐energy crystal plane and oxygen vacancy, 96.8 % Rhodamine B (10 mg ⋅ L−1) is degraded after irradiation of 30 min in T100‐VO photocatalytic system. This study provides a new strategy and inspiration for low‐cost control of semiconductor oxides and the design of efficient photocatalysts for environmental purification.