bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wicked Financing der Endlagerung: Ungewissheiten, Widersprüche und Herausforderungen
Authors: Brunnengräber Achim , Sieveking Jan 
Published: April 2024

ZusammenfassungDie finanzielle Verantwortung für die Entsorgung der hochradioaktiven Abfälle in Deutschland ging 2017 von den Betreibern der Atomkraftwerke (AKW) an den Staat über. Die Betreiber, die noch für den Rückbau der AKW verantwortlich sind, transferierten Rückstellungen in Höhe von 24,1 Mrd. EUR in den Fonds zur Finanzierung der kerntechnischen Entsorgung (KENFO). Der erste deutsche Staatsfonds, der von einer Stiftung des öffentlichen Rechts verwaltet wird, soll die Finanzierung so gewährleisten, dass keine zusätzlichen Kosten auf die Gesellschaft zukommen. Dafür soll die Stiftung die Mittel langfristig sichern und gewinnbringend anlegen. Zugleich hat die Stiftung die politische Aufgabe, bei ihren Investitionen an den Finanzmärkten Nachhaltigkeitskriterien zu berücksichtigen. Die staatliche Aufgabe der nuklearen Entsorgung erfährt damit eine Finanzialisierung: Finanzielle und gesellschaftlich-ökologische Kriterien werden miteinander verknüpft. Damit gehen Ungewissheiten und Widersprüche einher, die sich nur bedingt im Sinne eines gesellschaftlichen Nutzens auflösen lassen, was wir unter dem Begriff wicked financing zusammenfassen. Es bleibt ungewiss, ob das an den Finanzmärkten investierte Kapital bis zum Ende dieses Jahrhunderts und darüber hinaus für die Finanzierung der Endlagerung ausreicht. Es ist widersprüchlich, dass der Staatsfonds mit Demokratie- und Transparenzzielsetzungen kompatibel sein soll und gleichzeitig Aufgaben auch an externe Vermögensverwalter*innen auslagert. Schließlich stehen die Anlagestrategien im Widerspruch zu den Nachhaltigkeitskriterien, denn Investitionen erfolgen auch in Unternehmen der fossil-nuklearen Energiebranche.
Entstehung eines sinnvollen Wirtschaftssystems durch gesellschaftliche Selbststeuerung
Authors: Strangalies Christian 
Published: April 2024

ZusammenfassungIn diesem Kapitel wird aus systemtheoretischer Sicht beschrieben, wie ein nachhaltiges Wirtschaftssystem operiert. Es wird gezeigt, wie durch Reflexion die pathologische Selbstreferenz aufgelöst und durch eine Generalisierung stabilisiert wird. Es wird erläutert, wie eine begrenzte Reflexion in wirtschaftlichen Entscheidungen eine Selbststeuerung des Wirtschaftssystems ermöglicht und wie sie durch Fremdbeschreibungen beeinflusst werden kann.
Evolution einer sinnvollen Wirtschaft durch beschränkte Reflexion am Beispiel von Nachhaltigkeitsratings
Authors: Strangalies Christian 
Published: April 2024

ZusammenfassungDa die systemtheoretische Beschreibung einer begrenzten Reflexion sehr abstrakt ist, wird anhand von Nachhaltigkeitsratings ein konkretes Beispiel angeführt, wie Entscheidungen mit einer begrenzten Reflexion in Unternehmen entstehen können. Neben dem Bezug zu bestehender Literatur erfolgt die systemtheoretische Einordnung auch auf Basis von empirischen Erkenntnissen. Im folgenden Kapitel wird die Vorgehensweise der Untersuchung erläutert. Nach einer Beschreibung, wie die Evolution einer Wirtschaft mit begrenzter Reflexion entstehen kann, wird beschrieben, wie Nachhaltigkeitsratings durch ihre Reflexions- und Generalisierungsfunktion einen Reentry der Gesellschaft in die Wirtschaft unterstützen und damit einen Beitrag zur Selbststeuerung der Wirtschaft leisten.
Selbsterhaltung der Gesellschaft durch eine Wirtschaft mit begrenzter Reflexion
Authors: Strangalies Christian 
Published: April 2024

ZusammenfassungIn diesem Kapitel wird beschrieben, wie das politische System durch die Kontextsteuerung der Selbststeuerung der Wirtschaft mittels einer begrenzten Reflexion die Evolution zu einer sinnvollen Gesellschaft unterstützen kann. Im ersten Teil werden die Steuerungsmöglichkeiten der Politik beschrieben, die die Selbststeuerung einer Wirtschaft mit begrenzter Reflexion unterstützt. Anschließend wird dargestellt, wie die Kombination aus der Reflexion der Gesellschaft mithilfe von Netzwerken und der Generalisierung durch Nachhaltigkeit zu einem neuen Emergenz-Niveau der Gesellschaft führt.
On Vaulting: Heron’s Manuals and Their Role in Roman Dome Design
Authors: Roca Alicia , Juan-Vidal Francisco , Cipriani Luca , Fantini Filippo 
Published: April 2024

AbstractThe subject of domes in the Roman world is complex and can be studied from different perspectives. In this paper we focus on the relationship between Heron of Alexandria's manuals and the vaulting systems of the Hadrianic age. Our aim is to compare a selection of formulae from the critical edition by Johan Ludvig Heiberg with a series of buildings recently documented using photogrammetric and laser scanner technologies. The collection of writings Heronis Alexandrini opera quae supersunt omnia (mainly books IV and V) presents an interesting set of formulae for calculating vaults and domes: volumes and areas of niches, spherical segments, lunettes, as well as empirical strategies for calculating complex shapes. This approach, which integrates practical knowledge with Vitruvian graphic schemes, allows us to clarify the work of the ancient architect and consequently to investigate the architectural problem within the more general framework of archaeology with new conceptual tools.
EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
Authors: Huttunen Jasmin , Aaltonen Niina , Helminen Laura , Rilla Kirsi , Paakinaho Ville 
Published: April 2024

AbstractThe androgen receptor (AR) is a primary target for treating prostate cancer (PCa), forming the bedrock of its clinical management. Despite their efficacy, resistance often hampers AR-targeted therapies, necessitating new strategies against therapy-resistant PCa. These resistances involve various mechanisms, including AR splice variant overexpression and altered activities of transcription factors like the glucocorticoid receptor (GR) and FOXA1. These factors rely on common coregulators, such as EP300/CREBBP, suggesting a rationale for coregulator-targeted therapies. Our study explores EP300/CREBBP acetyltransferase inhibition’s impact on steroid receptor and FOXA1 signaling in PCa cells using genome-wide techniques. Results reveal that EP300/CREBBP inhibition significantly disrupts the AR-regulated transcriptome and receptor chromatin binding by reducing the AR-gene expression. Similarly, GR’s regulated transcriptome and receptor binding were hindered, not linked to reduced GR expression but to diminished FOXA1 chromatin binding, restricting GR signaling. Overall, our findings highlight how EP300/CREBBP inhibition distinctively curtails oncogenic transcription factors’ signaling, suggesting the potential of coregulatory-targeted therapies in PCa.
Enhancing Pisum sativum growth and symbiosis under heat stress: the synergistic impact of co-inoculated bacterial consortia and ACC deaminase-lacking Rhizobium
Authors: Ben Gaied Roukaya , Sbissi Imed , Tarhouni Mohamed , Brígido Clarisse 
Published: April 2024

AbstractThe 1-aminocyclopropane-1-carboxylate (ACC) deaminase is a crucial bacterial trait, yet it is not widely distributed among rhizobia. Hence, employing a co-inoculation approach that combines selected plant growth-promoting bacteria with compatible rhizobial strains, especially those lacking ACC deaminase, presents a practical solution to alleviate the negative effects of diverse abiotic stresses on legume nodulation. Our objective was to explore the efficacy of three non-rhizobial endophytes, Phyllobacterium salinisoli (PH), Starkeya sp. (ST) and Pseudomonas turukhanskensis (PS), isolated from native legumes grown in Tunisian arid regions, in improving the growth of cool-season legume and fostering symbiosis with an ACC deaminase-lacking rhizobial strain under heat stress. Various combinations of these endophytes (ST + PS, ST + PH, PS + PH, and ST + PS + PH) were co-inoculated with Rhizobium leguminosarum 128C53 or its ΔacdS mutant derivative on Pisum sativum plants exposed to a two-week heat stress period.Our findings revealed that the absence of ACC deaminase activity negatively impacted both pea growth and symbiosis under heat stress. Nevertheless, these detrimental effects were successfully mitigated in plants co-inoculated with ΔacdS mutant strain and specific non-rhizobial endophytes consortia. Our results indicated that heat stress significantly altered the phenolic content of pea root exudates. Despite this, there was no impact on IAA production. Interestingly, these changes positively influenced biofilm formation in consortia containing the mutant strain, indicating synergistic bacteria-bacteria interactions. Additionally, no positive effects were observed when these endophytic consortia were combined with the wild-type strain. This study highlights the potential of non-rhizobial endophytes to improve symbiotic performance of rhizobial strains lacking genetic mechanisms to mitigate stress effects on their legume host, holding promising potential to enhance the growth and yield of targeted legumes by boosting symbiosis.
Unveiling the pharmacological potential of plant triterpenoids in breast cancer management: an updated review
Authors: Aly Shaza H. , Elbadry Abdullah M. M. , Doghish Ahmed S. , El-Nashar Heba A. S. 
Published: April 2024

AbstractBreast cancer is the most prevalent type of cancer, the fifth leading cause of cancer-related deaths, and the second leading cause of cancer deaths among women globally. Recent research has provided increasing support for the significance of phytochemicals, both dietary and non-dietary, particularly triterpenoids, in the mitigation and management of breast cancer. Recent studies showed that triterpenoids are promising agents in the treatment and inhibition of breast cancer achieved through the implementation of several molecular modes of action on breast cancer cells. This review discusses recent innovations in plant triterpenoids and their underlying mechanisms of action in combating breast cancer within the timeframe spanning from 2017 to 2023. The present work is an overview of different plant triterpenoids with significant inhibition on proliferation, migration, apoptosis resistance, tumor angiogenesis, or metastasis in various breast cancer cells. The anticancer impact of triterpenoids may be attributed to their antiproliferative activity interfering with angiogenesis and differentiation, regulation of apoptosis, DNA polymerase inhibition, change in signal transductions, and impeding metastasis. The present review focuses on several targets, mechanisms, and pathways associated with pentacyclic triterpenoids, which are responsible for their anticancer effects. We could conclude that natural triterpenoids are considered promising agents to conquer breast cancer.
Graphical Abstract
Disrupted gut microecology after high-dose 131I therapy and radioprotective effects of arachidonic acid supplementation
Authors: Lu Ganghua , Gao Dingwei , Jiang Wen , Yu Xiaqing , Tong Junyu , Liu Xiaoyan , Qiao Tingting , Wang Ru , Zhang Mengyu , Wang Shaoping , Yang Jianshe , Li Dan , Lv Zhongwei 
Published: April 2024

Abstract
Background
Despite the potential radiotoxicity in differentiated thyroid cancer (DTC) patients with high-dose 131I therapy, the alterations and regulatory mechanisms dependent on intestinal microecology remain poorly understood. We aimed to identify the characteristics of the gut microbiota and metabolites in DTC patients suffering from high-dose 131I therapy and explore the radioprotective mechanisms underlying arachidonic acid (ARA) treatment.

Methods
A total of 102 patients with DTC were recruited, with fecal samples collected before and after 131I therapy for microbiome and untargeted and targeted metabolomic analyses. Mice were exposed to total body irradiation with ARA replenishment and antibiotic pretreatment and were subjected to metagenomic, metabolomic, and proteomic analyses.

Results
131I therapy significantly changed the structure of gut microbiota and metabolite composition in patients with DTC. Lachnospiraceae were the most dominant bacteria after 131I treatment, and metabolites with decreased levels and pathways related to ARA and linoleic acid were observed. In an irradiation mouse model, ARA supplementation not only improved quality of life and recovered hematopoietic and gastrointestinal systems but also ameliorated oxidative stress and inflammation and preserved enteric microecology composition. Additionally, antibiotic intervention eliminated the radioprotective effects of ARA. Proteomic analysis and ursolic acid pretreatment showed that ARA therapy greatly influenced intestinal lipid metabolism in mice subjected to irradiation by upregulating the expression of hydroxy-3-methylglutaryl-coenzyme A synthase 1.

Conclusion
These findings highlight that ARA, as a key metabolite, substantially contributes to radioprotection. Our study provides novel insights into the pivotal role that the microbiota-metabolite axis plays in radionuclide protection and offers effective biological targets for treating radiation-induced adverse effects.
Activation of STING by the novel liposomal TLC388 enhances the therapeutic response to anti-PD-1 antibodies in combination with radiotherapy
Authors: Chen Jhen-Yu , Lin Po-Yu , Hong Wei-Ze , Yang Pei-Chen , Chiang Shu-Fen , Chang Hsin-Yu , Ke Tao-Wei , Liang Ji-An , Chen William Tzu-Liang , Chao K. S. Clifford , Huang Kevin Chih-Yang 
Published: April 2024

AbstractCurrent immune checkpoint inhibiters (ICIs) have contrasting clinical results in poorly immunogenic cancers such as microsatellite-stable colorectal cancer (MSS-CRC). Therefore, understanding and developing the combinational therapeutics for ICI-unresponsive cancers is critical. Here, we demonstrated that the novel topoisomerase I inhibitor TLC388 can reshape the tumor immune landscape, corroborating their antitumor effects combined with radiotherapy as well as immunotherapy. We found that TLC388 significantly triggered cytosolic single-stranded DNA (ssDNA) accumulation for STING activation, leading to type I interferons (IFN-Is) production for increased cancer immunogenicity to enhance antitumor immunity. TLC388-treated tumors were infiltrated by a vast number of dendritic cells, immune cells, and costimulatory molecules, contributing to the favorable antitumor immune response within the tumor microenvironment. The infiltration of cytotoxic T and NK cells were more profoundly existed within tumors in combination with radiotherapy and ICIs, leading to superior therapeutic efficacy in poorly immunogenic MSS-CRC. Taken together, these results showed that the novel topoisomerase I inhibitor TLC388 increased cancer immunogenicity by ssDNA/STING-mediated IFN-I production, enhancing antitumor immunity for better therapeutic efficacy in combination with radiotherapy and ICIs for poorly immunogenic cancer.
The effects of spatially-constrained treatment regions upon a model of wombat mange
Authors: Hindle Ivy J. , Forbes Lawrence K. , Walters Stephen J. , Carver Scott 
Published: April 2024

AbstractThe use of therapeutic agents is a critical option to manage wildlife disease, but their implementation is usually spatially constrained. We seek to expand knowledge around the effectiveness of management of environmentally-transmitted Sarcoptes scabiei on a host population, by studying the effect of a spatially constrained treatment regime on disease dynamics in the bare-nosed wombat Vombatus ursinus. A host population of wombats is modelled using a system of non-linear partial differential equations, a spatially-varying treatment regime is applied to this population and the dynamics are studied over a period of several years. Treatment could result in mite decrease within the treatment region, extending to a lesser degree outside, with significant increases in wombat population. However, the benefits of targeted treatment regions within an environment are shown to be dependent on conditions at the start (endemic vs. disease free), as well as on the locations of these special regions (centre of the wombat population or against a geographical boundary). This research demonstrates the importance of understanding the state of the environment and populations before treatment commences, the effects of re-treatment schedules within the treatment region, and the transient large-scale changes in mite numbers that can be brought about by sudden changes to the environment. It also demonstrates that, with good knowledge of the host-pathogen dynamics and the spatial terrain, it is possible to achieve substantial reduction in mite numbers within the target region, with increases in wombat numbers throughout the environment.
Pregnancies in patients with systemic lupus erythematosus during 2000–2018 in Finland: a case–control study
Authors: Elfving Pia , Kariniemi Simo , Kautiainen Hannu , Rantalaiho Vappu , Virta Lauri J. , Puolakka Kari , Laine Merja K. 
Published: April 2024

Abstract
Objectives
The aim was to investigate, how pregnancies proceed in patients with systemic lupus erythematosus (SLE) compared to their individually matched population controls.

Material and methods
Adult incident SLE patients were identified from the register of new special reimbursement decisions for SLE drugs in 2000–2014. For each patient, 1–3 randomly selected controls from the Population Register Centre were matched. Data regarding pregnancies were obtained from the Finnish Medical Birth Register, Care Register and Register of Congenital Malformations until 2018. The study utilized data from the Drug Purchase Register and educational information from Statistic Finland.

Results
A total of 163 deliveries for 103 mothers with SLE and 580 deliveries for 371 population controls were identified. The duration of pregnancies in SLE women was significantly shorter compared to controls (38.9 versus 39.6 weeks). There were more urgent Caesarean Sections. (15% versus 9%) and need for care at neonatal intensive care unit (NICU) (21% versus 11%) among deliveries in SLE mothers. No statistical difference was observed between SLE and control groups in the occurrence of preeclampsia or major congenital malformations. Gestational age was 2.5 weeks shorter when the mother experienced pre-eclampsia. Hydroxychloroquine was purchased by 30% of SLE mothers during pregnancy.

Conclusion
The course of pregnancies in Finnish SLE patients seems to be quite moderate compared to controls, and no new safety issues were detected. The low utilization of hydroxychloroquine indicates that the benefits of the drug to pregnancy and disease course are not optimally recognized by specialists treating SLE mothers.
Application of honeycomb pattern to Ti2AlN MAX phase films by plasma etching
Authors: Duran Semih , Çiçek Hikmet , Korkmaz İsmail Hakkı , Efeoğlu İhsan 
Published: April 2024

AbstractThe honeycomb pattern possesses a distinctive hexagonal structure capable of seamless repetition on a flat surface, leaving no gaps. Moreover, all arm thicknesses and angles are equal to one another. This remarkable configuration is deemed biomimetic, with numerous examples found in nature. Notably, it exhibits remarkably low density and exceptional mechanical strength. MAX phase films have gathered significant attention due to their exceptional capacity to amalgamate the essential properties of both metals and ceramics. Additionally, they possess the unique ability to effectively mend surface cracks that may arise as a result of friction-wear, restoring the material to a certain degree of integrity. In this study, Ti2AlN MAX phase thin films were deposited on M2 steel substrates by a closed field unbalanced magnetron sputtering system (CFUBMS). 750 °C heat treatment was applied to obtain the produced films in crystalline form. In addition, plasma etching parameters suitable for the phase structure of the deposited film were determined. With the inductive coupling plasma etching (ICP) process, the honeycomb pattern was given to the Ti2AlN MAX phase films with a continuous and smooth geometry at a depth of 2 μm. This study gives ideas for the development of multi-coating systems in which patterns of different geometries are included in a single layer.
Semi-flexible majority rules for public good provision
Authors: Gersbach Hans , Tejada Oriol 
Published: April 2024

AbstractWe introduce semi-flexible majority rules for public good provision with private valuations. Such rules take the form of a two-stage, multiple-round voting mechanism where the output of the first stage is the default alternative for the second stage and the vote-share thresholds used in every round of binary voting (a) vary with the alternative on the table for a public-good level and (b) require a qualified majority for approving the alternative on the table by stopping the procedure. We show that these mechanisms implement the ex post utilitarian optimal public-good level, provided valuations can only be high or low. This public-good level is chosen after all potential socially optimal alternatives have been picked for a voting round. We explore ways to reduce the number of voting rounds and develop a compound mechanism when there are three or more valuation types.
StylePart: image-based shape part manipulation
Authors: Shen I.-Chao , Su Li-Wen , Wu Yu-Ting , Chen Bing-Yu 
Published: April 2024

Abstract
Direct part-level manipulation of man-made shapes in an image is desired given its simplicity. However, it is not intuitive given the existing manually created cuboid and cylinder controllers. To tackle this problem, we present StylePart, a framework that enables direct shape manipulation of an image by leveraging generative models of both images and 3D shapes. Our key contribution is a shape-consistent latent mapping function that connects the image generative latent space and the 3D man-made shape attribute latent space. Our method “forwardly maps” the image content to its corresponding 3D shape attributes, where the shape part can be easily manipulated. The attribute codes of the manipulated 3D shape are then “backwardly mapped” to the image latent code to obtain the final manipulated image. By using both forward and backward mapping, an user can edit the image directly without resorting to any 3D workflow. We demonstrate our approach through various manipulation tasks, including part replacement, part resizing, and shape orientation manipulation, and evaluate its effectiveness through extensive ablation studies.