bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of tremor in Wilson's disease by thalamotomy: A case report
Authors: Pal Pramod Kumar , Sinha Sanjib , Pillai Shibu , Taly Arun B. , Abraham Rojin G. 
Published: October 2007

AbstractLittle information is available on the surgical treatment of movement disorders in Wilson's disease. We report a successful outcome of left‐sided stereotactic thalamotomy in a 30‐year‐old man with Wilson's disease, who had severe postural‐kinetic tremor of both hands. The improvement was bilateral. Our case illustrates that stereotactic thalamotomy may be considered as an option in treating severe tremor in selected patients of Wilson's disease and merit further trials. © 2007 Movement Disorder Society
Trigonal injection of botulinum toxin‐A does not cause vesicoureteral reflux in neurogenic patients
Authors: Mascarenhas Frederico , Cocuzza Marcello , Gomes Cristiano Mendes , Leão Nilo 
Published: October 2007

AbstractAimsWe evaluated the effect of botulinum toxin type A (BTX‐A) injections in the trigone on the antireflux mechanism and evaluated its short‐term efficacy.Materials and MethodsBetween April and December 2006, 21 patients (10 men and 11 women) were prospectively evaluated. All were incontinent due to refractory NDO and underwent detrusor injection of 300 units of BTX‐A, including 50 units into the trigone. Baseline and postoperative evaluation after eight weeks included cystogram, urinary tract ultrasound and urodynamics.ResultsAt baseline, 20 patients had no vesicoureteral (VUR) and one had grade II unilateral VUR. Postoperative evaluation revealed no cases of de novo VUR and the patient with preinjection VUR had complete resolution of the reflux. Ultrasound showed 5 (23.8%) patients with hydronephrosis before BTX‐A injection and only one (4.8%) at the followup evaluation (p=0.066). After treatment, 9 (42.8%) patients became dry, 11 (52.4%) were improved and one (4.8%) had no improvement. Improved patients received antimuscarinic treatment and 8 (38.1%) became dry, with a final total continence rate of 80.1%. Cystometric capacity increased from 271±92 to 390±189 ml (p=0.002), reflex volume varied from 241±96 to 323±201 ml (p=0.020) and maximum detrusor pressure reduced from 66±39 to 38±37 cm H2O (p<0.001).ConclusionsOur results confirm the safety of trigone injections of BTX‐A in terms of development of VUR and upper urinary tract damage. Whether they are beneficial for patients with NDO or other causes of voiding dysfunction will need further studies. Neurourol. Urodynam. 27:311–314, 2008. © 2007 Wiley‐Liss, Inc.
A mixed shell formulation accounting for thickness strains and finite strain 3d material models
Authors: Klinkel Sven , Gruttmann Friedrich , Wagner Werner 
Published: October 2007

AbstractA non‐linear quadrilateral shell element for the analysis of thin structures is presented. The Reissner–Mindlin theory with inextensible director vector is used to develop a three‐field variational formulation with independent displacements, stress resultants and shell strains. The interpolation of the independent shell strains consists of two parts. The first part corresponds to the interpolation of the stress resultants. Within the second part independent thickness strains are considered. This allows incorporation of arbitrary non‐linear 3d constitutive equations without further modifications. The developed mixed hybrid shell element possesses the correct rank and fulfills the in‐plane and bending patch test. The essential
feature of the new element is the robustness in the equilibrium iterations. It allows very large load steps in comparison with other element formulations. We present results for finite strain elasticity, inelasticity, bifurcation and post‐buckling problems. Copyright © 2007 John Wiley & Sons, Ltd.
Advanced small cell carcinoma of the ovary in a seventeen‐year‐old female, successfully treated with surgery and multi‐agent chemotherapy
Authors: Kanwar Vikramjit S. , Heath Jessica , Krasner Carolyn N. , Pearce Jennifer M. 
Published: October 2007

AbstractAdvanced small cell carcinoma of the ovary (FIGO stage III or IV) is a rare and usually lethal tumor seen in adolescents and young women. In pediatric patients with advanced disease, there have been only two case reports of successful therapy, we report a third patient, diagnosed at 17 years of age, with an abdominal mass and metastatic disease to regional and distant lymph nodes, who was successfully treated with surgery and intensive multi‐agent chemotherapy. Imatinib, thalidomide, and celecoxib were also administered for up to 24 months following initial chemotherapy. She remains in remission 3 years from diagnosis. Pediatr Blood Cancer 2008;50:1060–1062. © 2007 Wiley‐Liss, Inc.
Review of image defined risk factors in localized neuroblastoma patients: Results of the GPOH NB97 trial
Authors: Simon Thorsten , Hero Barbara , Benz‐Bohm Gabriele , von Schweinitz Dietrich , Berthold Frank 
Published: October 2007

AbstractBackgroundRecently, an international expert group proposed revision of the International Neuroblastoma Staging System (INSS). Localized disease can be classified as L1 without and as L2 with image defined risk factors (IDRF published in JCO 2005; 23:8483–8489). Our aim was to evaluate IDRF for the prediction of resectability, complications, and outcome.ProcedureRecords of 520 localized neuroblastoma patients of the NB97 trial were reviewed. Patients were retrospectively classified as having IDRF or not. A total of 366 evaluable patients were then analyzed for extent and complications of surgery and the prognostic value of IDRF.ResultsAny IDRF was present in 26/160 of stage 1, 49/113 of stage 2, and 64/93 of stage 3 patients. Complete primary resection was achieved in 156/227 patients without IDRF and 43/139 patients with IDRF (P < 0.001). The frequency of complications was higher if any IDRF was present: 37/139 versus 33/227 (P = 0.006). Lack of IDRF was associated with better event free survival (3‐year‐EFS 86 ± 2% vs. 75 ± 4%, P = 0.010), whereas overall survival was similar (3‐year‐OS 98 ± 1% vs. 96 ± 2%, P = 0.462). EFS clearly depended on INSS stage (3‐year‐EFS 93 ± 2% in stage 1, 78 ± 4% in stage 2, and 69 ± 5% in stage 3, P < 0.001). OS was not different (3‐year‐OS 98 ± 1% vs. 99 ± 1% vs. 94 ± 2%, P = 0.056). Multivariate analysis demonstrated an impact of INSS stage on EFS only. IDRF were not shown to be significant for predicting EFS or OS.ConclusionsIDRF were useful in predicting risk and completeness of operation. IDRF failed as independent risk predictors in localized neuroblastoma. INSS more precisely identified patients with poor prognosis. Pediatr Blood Cancer 2008;50:965–969. © 2007 Wiley‐Liss, Inc.
Chronic metastatic neuroblastoma
Authors: Kazanowska Bernarda , Reich Adam , Jelen Michal , Chybicka Alicja 
Published: October 2007

AbstractThe diversity of neuroblastoma and its clinical course depends on histology, biology and clinical features. We report a male presenting at 4 months of age with an abdominal mass and multiple subcutaneous nodules. The diagnosis was made by histological examination of a subcutaneous nodule and elevated urinary markers. The patient remained well during the subsequent 9 years. During that time no cytostatic treatment was given. Attempt to treat with cis‐retinoic acid 10 years later did not result in any significant change of the clinical course. The patient has remained in good clinical condition for a 15‐year observation period, having both progressing and regressing distant subcutaneous metastases. Skin nodules are the hallmarks of the indolent clinical course of the disease. We suggest the use of the “chronic neuroblastoma” as a term to describe patients with neuroblastoma showing indolent disease course over a very long period of time, but never achieving complete remission. Pediatr Blood Cancer 2008;50:898–900. © 2007 Wiley‐Liss, Inc.
Longitudinal assessment of health‐related quality of life in preschool children with non‐CNS cancer after the end of successful treatment
Authors: Maurice‐Stam Heleen , Oort Frans J. , Last Bob F. , Brons Paul P.T. , Caron Huib N. , Grootenhuis Martha A. 
Published: October 2007

AbstractBackgroundThe aim of the study was to access Health Related Quality of Life (HRQoL) in preschool cancer survivors during the first 3 years of continuous remission after the end of successful treatment, and to identify predictors of HRQoL.ProcedureParent‐reported HRQoL was assessed in 53 preschool children treated successfully for cancer, using the TAPQOL and compared with norm data. Longitudinal mixed models analyses were performed to investigate to what extent demographic and medical variables and parental psychological distress were predictive of HRQoL over time.ResultsTwo months after the end of successful cancer treatment, survivors showed significantly (P < 0.01) more problem behavior and anxiety, and scored significantly worse (P < 0.01) on sleeping, motor functioning, positive mood and liveliness than the norm. One year after the end of treatment survivors still showed significantly (P < 0.01) more anxiety and worse motor functioning. The level of HRQoL in survivors had normalized 2 and 3 years after the end of treatment. Longer duration of treatment, bad prognosis and greater parental psychological distress were associated with worse scores on the Physical Component Score of the TAPQOL. Medical variables and parental psychological distress were not associated with the Mental Component Score.ConclusionsSurvivors adjusted well to the cancer experience and HRQoL improved with time. Despite overall resilience in survivors over time, physical as well as psychosocial monitoring in follow‐up is recommended. Standard aftercare should preferably include psychosocial screening, education, and counseling directed at both survivors and parents. Pediatr Blood Cancer 2008;50:1047–1051. © 2007 Wiley‐Liss, Inc.
Synthesis of linear and hyperbranched poly(etherketone)s containing flexible oxyethylene spacers
Authors: Jeon In‐Yup , Tan Loon‐Seng , Baek Jong‐Beom 
Published: October 2007

AbstractAs an alternative to strong acid reaction media for the Friedel–Crafts acylation for a polymer‐forming reaction, a mild polyphosphoric acid (PPA) with optimized amount of phosphorous pentoxide (P2O5) has been tested for the polymerization of AB monomers 4‐(2‐phenoxyethoxy)benzoic acid and 3‐(2‐phenoxyethoxy)benzoic acid, and an AB2 monomer 3,5‐bis(2‐phenoxyethoxy)benzoic acid. The reaction progress of AB2 monomer was conveniently traced by FTIR spectroscopy monitoring aromatic ketone (CO) stretching bands arisen from carboxylic acid groups at the chain ends and carbonyl groups in the backbone as a function of reaction time at 110 °C. The resultant linear and hyperbranched polymers containing flexible oxyethylene spacers, which were prone to be hydrolyzed in strong acids at elevated temperature, displayed high intrinsic viscosities. Thus, the reaction medium PPA/P2O5 mixture as an electrophilic substitution reaction was indeed benign not to depolymerize growing polymer molecules but strong enough for the direct generation of carbonium ion from carboxylic acid to promote efficient polymerization. The resultant hyperbranched poly(etherketone) (PEK) displayed the best solubility among samples. All PEKs showed good thermal stability; glass transition temperatures were in the range of 90–117 °C; 5% weight loss generally occurred at greater than 345 °C in air. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5112–5122, 2007
Miktoarm star copolymers of poly(ϵ‐caprolactone) from a novel heterofunctional initiator
Authors: Priftis Dimitrios , Pitsikalis Marinos , Hadjichristidis Nikos 
Published: October 2007

AbstractA novel heterofunctional initiator, synthesized from pentaerythritol in a three step reaction sequence with two ring opening polymerization (ROP) and two atom transfer radical polymerization (ATRP) initiating sites, was used to prepare A2B2 miktoarm star copolymers of poly(ε‐caprolactone), PεCL, with polystyrene, PS, poly(methyl methacrylate), PMMA, poly(dimethylaminoethyl methacrylate), PDMAEMA, and poly(2‐hydroxyethyl methacrylate), PHEMA. A2B miktoarm stars, A being PεCL or poly(δ‐valerolactone), PδVL and B PS were also prepared from ω,ω‐dihydroxy‐PS, synthesized from ω‐Br‐PS and serinol, by ROP of εCL or δVL. All polymers were characterized by size exclusion chromatography, 1H NMR spectroscopy, and membrane osmometry. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5164–5181, 2007
Crystal structure and theoretical calculations of Julocrotine, a natural product with antileishmanial activity
Authors: Moreira Rafael Y. O. , Brasil Davi S. B. , Alves Cláudio N. , Guilhon Giselle M. S. P. , Santos Lourivaldo S. , Arruda Mara S. P. , Müller Adolfo H. , Barbosa Patrícia S. , Abreu Alcicley S. , Silva Edilene O. , Rumjanek Victor M. , Souza Jaime , da Silva Albérico B. F. , Santos Regina H. de A. 
Published: October 2007

AbstractJulocrotine, N‐(2,6‐dioxo‐1‐phenethyl‐piperidin‐3‐yl)‐2‐methyl‐butyramide, is a potent antiproliferative agent against the promastigote and amastigote forms of Leishmania amazonensis (L.). In this work, the crystal structure of Julocrotine was solved by X‐ray diffraction, and its geometrical parameters were compared with theoretical calculations at the B3LYP and HF level of theory. IR and NMR spectra also have been obtained and compared with theoretical calculations. IR absorptions calculated with the B3LYP level of theory employed together with the 6‐311G+(d,p) basis set, are close to those observed experimentally. Theoretical NMR calculations show little deviation from experimental results. The results show that the theory is in accordance with the experimental data. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2008
Characterization of the NH···ON and NH···NO H‐bonds in nitrosamine dimers
Authors: Roohi H. , Gholipour Y. 
Published: October 2007

AbstractAb initio molecular orbital and DFT calculations have been carried out for three most stable dimers of parent nitrosamine (NA) in order to elucidate the structures and energetics of the dimers. The structures were optimized using HF, B3LYP, and MP2 methods with 6‐311+G(d,p) and 6‐311++G(2d,2p) basis sets. At the optimized geometries obtained at MP2/6‐311++G(2d,2p) level of theory, the energies were evaluated at QCISD/aug‐cc‐pVDZ and CCSD/aug‐cc‐pVDZ levels. The most stable dimer has two NH···ON hydrogen bonds and the least stable dimer has two NH···NO hydrogen bonds. The natural bond orbital analysis showed that the lpO(N) → BD*(NN) and lpO(N) → BD*(NHb) interactions play a decisive role in the stabilization of the NH···O(N) hydrogen bonds in dimers. The atoms in molecules results reveal that the intermolecular NH···O(N) H‐bonds in dimers have electrostatic character. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2008
Stability, structural properties, and dissociation pathways of silylidyne‐amines RSiN and silylidyne‐phosphanes RSiP (R = F, Cl)
Authors: Bhattacharyya I. , Bera N. C. , Das A. K. 
Published: October 2007

AbstractStability, structural properties, and dissociation pathways of silylidyne‐amines FSiN, ClSiN, their isomers, and silylidyne‐phosphanes FSiP and ClSiP have been studied in detail using ab initio MP2, CCSD, and CCSD(T) and density functional B3LYP methods. After dissociation of FSiN, ClSiN, FSiP, and ClSiP, the fragmented atoms have been considered to be either in their ground state or in their metastable state in various dissociation channels. The dissociation energy for various dissociation pathways has been compared and interesting results have been obtained for the dissociation channels where the fragmented atoms are in their metastable states. The structure properties of these molecules agree well with the theoretical results wherever available. The NBO atomic charges of these molecules have been analyzed. The isomerization energy has been compared with existing theoretical data. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2008
A tracer investigation of chromic acid anodizing of aluminium
Authors: Garcia‐Vergara S. J. , Skeldon P. , Thompson G. E. , Habazaki H. 
Published: October 2007

AbstractA tungsten tracer introduced into a sputtering‐deposited aluminium substrate was employed to investigate pore development in anodic films formed at 3 mA cm−2 in 0.25 M chromic acid electrolyte at 313 K. The anodized specimens were observed by transmission electron microscopy (TEM), with compositions of films determined by Rutherford backscattering spectroscopy (RBS). The anodic films were found to be similar in thickness to that of the aluminium layer consumed during anodizing and revealed the feathered pore morphology that is a characteristic of the electrolyte. The anodizing efficiency was ∼45–48%, with tungsten tracer species, in addition to aluminium species, being lost to the electrolyte at the pore base. These findings, together with the relatively uniform distribution of tungsten species within the film, are consistent with field‐assisted dissolution of the alumina playing a major role in the development of pores. The films contrast with those formed in phosphoric and sulphuric acid electrolytes, for which feathering of pores is absent, the tracer distribution is inverted and the film thickness exceeds that of the consumed metal, features indicative of the influence of material flow in pore development. Copyright © 2007 John Wiley & Sons, Ltd.
Misspecification tests for binomial and beta‐binomial models
Authors: Capanu Marinela , Presnell Brett 
Published: October 2007

AbstractThe IOS test of Presnell and Boss (J. Am. Stat. Assoc. 2004; 99(465):216–227) is a general‐purpose goodness‐of‐fit test based on the ratio of in‐sample and out‐of‐sample likelihoods. For large samples, the IOS statistic can be approximated by a multiplicative contrast between two estimates of the information matrix, and in this way the IOS test is connected to White's (Econometrica 1982; 50:1–26) information matrix test, or IM test, which is based directly on the difference of two estimates of the information matrix. In this paper, we compare the performance of IOS to that of the IM test and of other goodness‐of‐fit tests for binomial and beta‐binomial models, in both examples and simulations. Our findings suggest that IOS is strongly competitive, not only against the IM test but also against tests designed for specific binomial and beta‐binomial models. Copyright © 2007 John Wiley & Sons, Ltd.
Preservation of effect and the regulatory approval of new treatments on the basis of non‐inferiority trials
Authors: Snapinn Steven , Jiang Qi 
Published: October 2007

AbstractThe criteria for approval of an experimental treatment on the basis of active‐controlled non‐inferiority trials often include demonstration of ‘preservation of effect’ relative to the active control. While this appears on its surface to be a reasonable criterion, on closer inspection it can be shown to lead to serious logical inconsistencies. In particular, an experimental treatment may have clinical trial results that are superior to those for the standard treatment and yet fail to meet this criterion for approval. In this paper we propose a set of principles that will help avoid these logical inconsistencies, and we argue that the qualities of an experimental treatment that are required for approval should be consistent regardless of the presence or absence of existing treatments and the type of study design used to evaluate the treatment. Copyright © 2007 John Wiley & Sons, Ltd.
SUMLOW: early design‐stage sketching of UML diagrams on an E‐whiteboard
Authors: Chen Qi , Grundy John , Hosking John 
Published: October 2007

AbstractMost visual diagramming tools provide point‐and‐click construction of computer‐drawn diagram elements using a conventional desktop computer and mouse. SUMLOW is a unified modelling language (UML) diagramming tool that uses an electronic whiteboard (E‐whiteboard) and sketching‐based user interface to support collaborative software design. SUMLOW allows designers to sketch UML constructs, mixing different UML diagram elements, diagram annotations, and hand‐drawn text. A key novelty of the tool is the preservation of hand‐drawn diagrams and support for manipulation of these sketches using pen‐based actions. Sketched diagrams can be automatically ‘formalized’ into computer‐recognized and ‐drawn UML diagrams and then exported to a third party CASE tool for further extension and use. We describe the motivation for SUMLOW, illustrate the use of the tool to sketch various UML diagram types, describe its key architecture abstractions and implementation approaches, and report on two evaluations of the toolset. We hope that our experiences will be useful for others developing sketching‐based design tools or those looking to leverage pen‐based interfaces in software applications. Copyright © 2007 John Wiley & Sons, Ltd.
Modelling of power fluctuations from large offshore wind farms
Authors: Sørensen Poul , Cutululis Nicolaos Antonio , Vigueras‐Rodríguez Antonio , Madsen Henrik , Pinson Pierre , Jensen Leo E. , Hjerrild Jesper , Donovan Martin 
Published: October 2007

AbstractThis paper deals with modelling of power fluctuations from large wind farms. The modelling is supported and validated using wind speed and power measurements from the two large offshore wind farms in Denmark. The time scale in focus is from 1min to a couple of hours, where significant power fluctuations have been observed from these wind farms. Power and wind speed are measured with 1s sampling time in all individual wind turbines in almost 1 year, which provides a substantial database for the analyses. The paper deals with diversified models representing each wind turbine individually and with aggregation of a wind farm to be represented by a single large wind turbine model. Copyright © 2007 John Wiley & Sons, Ltd.
Correlation of CK‐20‐Positive Cells in Peripheral Venous Blood with Serum CEA Levels in Patients with Colorectal Carcinoma
Authors: Friederichs Jan , Gertler Ralf , Rosenberg Robert , Dahm Michael , Nekarda Hjalmar , Holzmann Bernhard , Siewert Jörg Rüdiger 
Published: October 2007

AbstractTumor cell dissemination appears to be an early event in tumor progression, and tumor cells can be detected in peripheral venous blood at the time of the operation. Although cytokeratin 20 (CK‐20) is not specifically expressed by colorectal carcinomas, it represents a widely used marker for the detection of colorectal tumor cells. We used the combination of density centrifugation and CK‐20 real‐time reverse transcription polymerase chain reaction to detect CK‐20‐positive cells in the peripheral venous blood of 37 patients with colorectal carcinoma. Detection rates were compared to serum levels of the tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen CA 19‐9, and cancer antigen CA 125. The prognostic impact was assessed by the overall survival and by univariate and multivariate analysis. Overall, CK‐20‐positive cells in peripheral venous blood were detected in 11 of 37 (29.7%) patients. CK‐20‐positive patients showed a significantly higher mean serum CEA level (90.3 ng/ml) than the 4.1 ng/ml found in the CK‐20‐negative group (p = 0.03). CEA levels also correlated with CK‐20 copy numbers. No significant correlation was observed for CA 19‐9 or CA 125. CK‐20‐negative patients showed a trend toward better survival (p = 0.08). In the univariate analysis, CA 19‐9, CEA, tumor size, lymph node status, grading, the presence of distant metastases, and resection status reached significant prognostic levels, whereas the detection of CK‐20‐positive cells showed only a prognostic trend (p = 0.06). Multivariate analysis failed to identify independent prognostic parameters. Here we report the correlation of CK‐20‐positive cells in peripheral venous blood with the serum CEA level of patients with colorectal cancer, which may represent a potential marker of the tumor load.