bluuebunny/crossref_metadata_2025_split huggingface dataset:
ReSA: Reconfigurable Systolic Array for Multiple Tiny DNN Tensors
Authors: Lee Ching-Jui , Yeh Tsung Tai 
Published: March 2024

Systolic array architecture has significantly accelerated deep neural networks (DNNs). A systolic array comprises multiple processing elements (PEs) that can perform multiply-accumulate (MAC). Traditionally, the systolic array can execute a certain amount of tensor data that matches the size of the systolic array simultaneously at each cycle. However, hyper-parameters of DNN models differ across each layer and result in various tensor sizes in each layer. Mapping these irregular tensors to the systolic array while fully utilizing the entire PEs in a systolic array is challenging. Furthermore, modern DNN systolic accelerators typically employ a single dataflow. However, such a dataflow is not optimal for every DNN model.
This work proposes ReSA, a reconfigurable dataflow architecture that aims to minimize the execution time of a DNN model by mapping tiny tensors on the spatially partitioned systolic array. Unlike conventional systolic array architectures, the ReSA data path controller enables the execution of the input, weight, and output-stationary dataflow on PEs. ReSA also decomposes the coarse-grain systolic array into multiple small ones to reduce the fragmentation issue on the tensor mapping. Each small systolic sub-array unit relies on our data arbiter to dispatch tensors to each other through the simple interconnected network. Furthermore, ReSA reorders the memory access to overlap the memory load and execution stages to hide the memory latency when tackling tiny tensors. Finally, ReSA splits tensors of each layer into multiple small ones and searches for the best dataflow for each tensor on the host side. Then, ReSA encodes the predefined dataflow in our proposed instruction to notify the systolic array to switch the dataflow correctly. As a result, our optimization on the systolic array architecture achieves a geometric mean speedup of 1.87× over the weight-stationary systolic array architecture across nine different DNN models.
A Signal-Finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration–Resistant Prostate Cancer: Results from CYCLONE 1
Authors: Agarwal Neeraj , Castellano Daniel , Alonso-Gordoa Teresa , Arranz Arija Jose Angel , Colomba Emeline , Gravis Gwenaelle , Mourey Loic , Oudard Stephane , Fléchon Aude , González Macarena , Rey Pablo M. , Schweizer Michael T. , Gallardo Enrique , Johnston Erica , Balar Arjun , Haddad Nadine , Appiah Adams K. , Nacerddine Karim , Piulats José M. 
Published: March 2024

Abstract

Purpose:
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors radically changed the treatment paradigm for breast cancer. Similar to estrogen receptor in breast cancer, androgen receptor signaling activates cyclin D–CDK4/6, driving proliferation and resistance to hormonal manipulation in prostate cancer. This study was designed to detect signals of clinical activity for abemaciclib in treatment-refractory metastatic castration-resistant prostate cancer (mCRPC).

Patients and Methods:
Eligible patients had progressive mCRPC, measurable disease, and previously received ≥1 novel hormonal agent(s) and 2 lines of taxane chemotherapy. Abemaciclib 200 mg twice daily was administered on a continuous dosing schedule. Primary endpoint was objective response rate (ORR) without concurrent bone progression. This study was designed to detect a minimum ORR of 12.5%.

Results:
At trial entry, 40 (90.9%) of 44 patients had objective radiographic disease progression, 4 (9.1%) had prostate-specific antigen (PSA)–only progression, and 20 (46.5%) had visceral metastases (of these, 60% had liver metastases). Efficacy analyses are as follows: ORR without concurrent bone progression: 6.8%; disease control rate: 45.5%; median time to PSA progression: 6.5 months [95% confidence interval (CI), 3.2–NA]; median radiographic PFS; 2.7 months (95% CI, 1.9–3.7); and median OS, 8.4 months (95% CI, 5.6–12.7). Most frequent grade ≥3 treatment-emergent adverse events (AE) were neutropenia (25.0%), anemia, and fatigue (11.4% each). No grade 4 or 5 AEs were related to abemaciclib.

Conclusions:
Abemaciclib monotherapy was well tolerated and showed clinical activity in this heavily pretreated population, nearly half with visceral metastases. This study is considered preliminary proof-of-concept and designates CDK4/6 as a valid therapeutic target in prostate cancer.
Subtype-Specific Association of Mitochondrial DNA Copy Number With Poststroke/TIA Outcomes in 10 241 Patients in China
Authors: Jiang Yi , Cheng Si , Shi Yanfeng , Xu Zhe , Wang Huihui , Li Yanran , Liu Yang , Li Zixiao , Jiang Yong , Meng Xia , Cheng Shanshan , Li Hao , Wang Chaolong , Wang Yongjun 
Published: March 2024

BACKGROUND:
Mitochondrial DNA copy number (mtDNA-CN) is associated with the severity and mortality in patients with stroke, but the associations in different stroke subtypes remain unexplored.

METHODS:
We conducted an observational prospective cohort analysis on patients with ischemic stroke or transient ischemic attack enrolled in the Third China National Stroke Registry. We applied logistic models to assess the association of mtDNA-CN with functional outcome (modified Rankin Scale score, 3–6 versus 0–2) and Cox proportional hazard models to assess the association with stroke recurrence (treating mortality as a competing risk) and mortality during a 12-month follow-up, adjusting for sex, age, physical activity, National Institutes of Health Stroke Scale at admission, history of stroke and peripheral artery disease, small artery occlusion, and interleukin-6. Subgroup analyses stratified by age and stroke subtypes were conducted.

RESULTS:

The Third China National Stroke Registry enrolled 15 166 patients, of which 10 241 with whole-genome sequencing data were retained (mean age, 62.2 [SD, 11.2] years; 68.8% men). The associations between mtDNA-CN and poststroke/transient ischemic attack outcomes were specific to patients aged ≤65 years, with lower mtDNA-CN significantly associated with stroke recurrence in 12 months (subdistribution hazard ratio, 1.15 per SD lower mtDNA-CN [95% CI, 1.04–1.27];
P
=5.2×10
−3
) and higher all-cause mortality in 3 months (hazard ratio, 2.19 [95% CI, 1.41–3.39];
P
=5.0×10
−4
). Across subtypes, the associations of mtDNA-CN with stroke recurrence were specific to stroke of undetermined cause (subdistribution hazard ratio, 1.28 [95% CI, 1.11–1.48];
P
=6.6×10
−4
). In particular, lower mtDNA-CN was associated with poorer functional outcomes in stroke of undetermined cause patients diagnosed with embolic stroke of undetermined source (odds ratio, 1.53 [95% CI, 1.20–1.94];
P
=5.4×10
−4
), which remained significant after excluding patients with recurrent stroke (odds ratio, 1.49 [95% CI, 1.14–1.94];
P
=3.0×10
−3
).

CONCLUSIONS:
Lower mtDNA-CN is associated with higher stroke recurrence rate and all-cause mortality, as well as poorer functional outcome at follow-up, among stroke of undetermined cause, embolic stroke of undetermined source, and younger patients.
Effect of Intermittent Oro-Esophageal Tube Feeding in Bulbar Palsy After Ischemic Stroke: A Randomized Controlled Study
Authors: Zeng Hongji , Zhao Weijia , Wu Junfa , Wei Jihong , Li Heping , Wang Liugen , Zeng Xi 
Published: March 2024

BACKGROUND:
Nasogastric tube feeding (NG) has been widely used in patients with bulbar palsy after ischemic stroke but is associated with a significant risk of complications including malnutrition and pneumonia. Intermittent oro-esophageal tube feeding (IOE) can help alleviate these concerns. This study explored the clinical effect of IOE versus NG on nutritional status, swallowing function, stroke-associated pneumonia, and depression in patients with bulbar palsy after ischemic stroke.

METHODS:

This randomized controlled study included 148 patients with bulbar palsy after ischemic stroke who underwent routine treatment and swallowing rehabilitation training in the Department of Rehabilitation Medicine between July 2017 and July 2019 in China. The participants were randomly divided into the IOE group (n=74) and NG group (n=74) with IOE and NG as nutritional supports, respectively. The primary outcome was nutritional status including (1) body mass index (kg/m
2
), (2) serum ALB (albumin, g/L), and (3) PA (prealbumin, mg/L). The secondary outcomes were (1) swallowing function including (i) Functional Oral Intake Scale (FOIS) and (ii) Penetration-Aspiration Scale, (2) pneumonia, (3) depression, and (4) adverse events. Statistical analyses for continuous outcomes were performed using
t
test, Mann-Whitney
U
test and Wilcoxon signed-rank test and categorical variables using χ
2
test. SPSS 21.0 was used for all analysis.

RESULTS:

There were no significant baseline differences between the 2 groups. After the treatment, the IOE group demonstrated significantly better results compared with the NG group in ALB ([32.71±0.94] versus [32.28±0.81] g/L;
P
=0.003), PA ([278.15±13.81] versus [270.31±15.08] mg/L;
P
=0.001], body mass index ([19.77±1.03] versus [19.41±0.98] kg/m
2
;
P
=0.002], FOIS (
P
<0.001), Penetration-Aspiration Scale (
P
<0.001), stroke-associated pneumonia ([1, 4.05%] versus [26, 35.14%];
P
<0.001), depression ([1, 1.35%] versus [44, 59.46%];
P
<0.001) and overall less adverse events (reflux, fever, discomfort in the throat;
P
<0.001).

CONCLUSIONS:
In patients with dysphagia with bulbar palsy after ischemic stroke who received routine treatment and swallowing rehabilitation training, IOE is safer and more conducive to the improvement of nutritional status, swallowing function, stroke-associated pneumonia, and depression than NG.

REGISTRATION:

URL:
https://www.chictr.org.cn
; Unique identifier: ChiCTR-INC-17011741.
High performers demonstrate greater neural synchrony than low performers across behavioral domains
Authors: Chamberlain Taylor A. , Corriveau Anna , Song Hayoung , Kwon Young Hye , Yoo Kwangsun , Chun Marvin M. , Rosenberg Monica D. 
Published: March 2024

Abstract
Heterogeneity in brain activity can give rise to heterogeneity in behavior, which in turn comprises our distinctive characteristics as individuals. Studying the path from brain to behavior, however, often requires making assumptions about how similarity in behavior scales with similarity in brain activity. Here, we expand upon recent work (Finn et al., 2020) which proposes a theoretical framework for testing the validity of such assumptions. Using intersubject representational similarity analysis in two independent movie-watching functional MRI (fMRI) datasets, we probe how brain-behavior relationships vary as a function of behavioral domain and participant sample. We find evidence that, in some cases, the neural similarity of two individuals is not correlated with behavioral similarity. Rather, individuals with higher behavioral scores are more similar to other high scorers whereas individuals with lower behavioral scores are dissimilar from everyone else. Ultimately, our findings motivate a more extensive investigation of both the structure of brain-behavior relationships and the tacit assumption that people who behave similarly will demonstrate shared patterns of brain activity.
Homoousios or Homoiosis
Authors: Conty Arianne 
Published: March 2024

Abstract
This article will elucidate the philosophy of the image that developed in the wake of the Iconoclastic Controversy in the Eastern Christian Empire in the ninth Century. Iconophilia was finally reinstated after a wave of iconoclasm swept across the Empire. The controversy coincides with dramatic changes within the Byzantine empire, making it difficult to establish consensus amongst scholars regarding its possible causes. After discussing several of the theories that seek to explain the adoption of iconoclasm in the Byzantine Empire, we will seek to show how image veneration was transformed and differentiated from relic worship thanks to its encounter with iconoclasm. After reviewing icon veneration prior to the Iconoclastic Controversy, this article will elucidate the philosophy of the image developed by Patriarch Nicephorus in order to show how he differentiated veneration from idolatry by redefining the image as “similar to” (homoiosis) rather than consubstantial with (homoousios) its model. By differentiating image veneration from the theory of consubstantiality that was normative within Judaism and Islam, Christian philosophy of the image will differentiate resemblance from identity, inscription from circumscription, and thereby reveal iconoclasm to be in the eye of the beholder.
Mismatching Fragments from the Excerpta Constantiniana
Authors: Németh András 
Published: March 2024

Abstract
The Excerpta Constantiniana, the scarce remains of the Byzantine Emperor Constantine VII’s (sole r. 945–959) ambitious project to systematize historical works in Greek, has been long understood as a rich repository of fragments from historical texts that no longer survive in their entirety. Since the late sixteenth century, this notion encouraged antiquarian philologists to assemble fragments from otherwise lost works. The concept of reassembling fragments into lost wholes relied on the analogy of solid objects which are fragmented and can be re-unified, implying the uniformity of a single fragment. The case of the dialogue between Polybius and the weeping Scipio Aemilanus is particularly illustrative. It was first excavated as a solid fragment from Appian and became a Polybian fragment for centuries. The discovery of two versions, a legible one from Diodorus and the illegible from Polybius encouraged the reconstruction of the Polybian version based on the alternative versions, especially Appian’s. The new reading of the Polybian version in Vat. gr. 73, facilitated by multispectral photography, demonstrates that such reconstructions were at some points incorrect.
A Manuscript Used as Printer’s Copy for the Ovid of Sweynheym and Pannartz
Authors: Little William L. 
Published: March 2024

Abstract
This short note identifies in Ott. lat. 1972 texts of Ovid’s Epistulae ex Ponto and Heroides 15 that served as copy for the Roman editio princeps of those works printed by Sweynheym and Pannartz in 1471.
On the Yašt Gāhān (= Gāh Sārnā)
Authors: König Götz 
Published: March 2024

Abstract
The Gāϑās are known to be a central building block of the Yasna/Visparad liturgy as well as of the Vīdēvdād Sāde and Vīštāsp Yašt Sāde, liturgies which are based on the Visparad. The functional difference of these liturgies (the Yasna/Visparad are intertwined with sacrificial, the Vīdēvdād with purification acts; the function of the Vīštāsp Sāde is obscure) shows that the Gāϑās can be used in a variety of ritual contexts, in other words, that they are hermeneutically open.
In Zoroastrian Studies the impression prevails that the Gāϑās could and can be used only in connection with their Younger Avestan embedding in the Yasna and in the Long Liturgy. However, with the text Yašt Gāhān, in which the first Gāϑā encounters a liturgical embedding that corresponds to that of the so-called Short Liturgies, there is a counter-example attested to in the manuscripts. Remnants of a parallel use of the second Gāϑā indicate a) that once (probably before the 2nd millennium CE) all five Gāϑās could be recited in the way the Yašt Gāhān is recited still today, and b) that the five Gāϑās formed perhaps a liturgical sequence also beyond the Yasna ritual complex. Since the Yašt Gāhān is a liturgy in the context of the rites of the dead – it is recited at the moment when the corpse is lifted up and carried out of the house – it seems reasonable to assume that a recitation of all five Gāϑās formed once the chant accompanying the dead from the place of death to the daxme. Furthermore, there are indications that there was a connection between the separate recitation of the five Gāϑās and the five (or twice five) year-end days named after the five Gāϑās.
Labour Values and Production Prices  in Joint Production
Authors: Stamatis Georg 
Published: March 2024

In this article, we show that in joint production, both labour values and production prices are positive but not unambiguously determined. Usually, the former is determined under the implicit presupposition that labour productivity in the production of each commodity is the same in all production processes that produce this commodity, and the latter is determined under the indirect presupposition that the capital productivity in the production of each commodity is the same in all production processes, with the consequence that this also applies to the maximum profit rate. This presupposition is equivalent to a transformation of joint into single production—not in the ‘space’ of material quantities but in that of corresponding nominal quantities in terms of labour values or production prices, respectively. The same presupposition is not only arbitrary but also, in the case of separable technique, contradicts the technical data of the given production technique. The same applies to the above transformation of joint into simple production, which is made possible under this presupposition. Consequently, either no theory of joint production based on nominal quantities is possible, or, when it is possible, it is based on an arbitrary and, in some cases, contradictory presupposition. JEL Codes: B50, B51, B59
Effect of drama training on self-esteem and personality strengths: A feasibility case control study of nidotherapy
Authors: Mansell Chelsea , Yang Min , Tyrer Peter 
Published: March 2024

Background: Although there are many case reports and qualitative studies on the likely positive effects of drama on mental health there have been few quantitative studies with mentally ill patients. Aims: To assess the effect of drama training in patients receiving nidotherapy with a range of mental and personality disorders on changes in self-esteem and personality strengths over a 1-month period compared with two control groups, one with similar mental disorders and another without, who had similar assessments but no acting involvement. Method: A total of 19 patients were recruited from a mental health charity with current significant mental illness (active group: n = 6) (b) a control group of patients with current mental illness who were not involved in acting ( n = 5), and an additional control group with no current mental illness ( n = 8) The patients involved in drama were taking part in nidotherapy, an environmental intervention. Two self-rating scales, the Rosenberg Self-Esteem Scale (RSES) and Abbreviated Personality Strengths Scale (APSS) recorded changes in self-esteem and personality strengths at base-line and after 1 month in the participants. Random effects modelling was used to analyse the data. Results: The intervention group showed positive improvement in personality strengths ( p = .009) compared to the control group that had no mental illness, and also improved more than the control group with mental illness but not to a significant degree ( p = .16). Self-esteem recorded with the Rosenberg scale was lower in those in the acting group at baseline compared with the other two groups ( p = .088) but after acting training improved by 29% to be equivalent to the control groups. Conclusions: Despite the limited numbers in this study, and the consequent inability to make firm conclusions about the efficacy of drama therapy as part of nidotherapy, the findings suggest that larger trials of this approach are feasible and worth exploring. .
The Utility of Virtual Home Visits to Reduce Asthma Burden in Low-Income Black Communities in Louisiana During the COVID-19 Pandemic
Authors: Bakshi Arundhati , Apantaku Elora , Marquette Tracy , Jacob Colette , Dumas S. Amanda , Friedman Kate , Aubin Kathleen , Soileau Shannon , Kemmerly Shaun 
Published: March 2024

Objectives: The Louisiana Department of Health identified a need for greater outreach in low-income Black communities that addressed environmental asthma triggers. We piloted an asthma virtual home visit (VHV) program and evaluated its reach and ability to promote asthma self-management strategies in communities with a high prevalence of poorly controlled asthma. Methods: Participants from Louisiana were continuously recruited into the VHV program starting in March 2021 and provided with asthma education materials. Participants reporting poorly controlled asthma and environmental triggers were also offered 3 VHVs with a respiratory therapist. All participants were asked to complete a preintervention and postintervention knowledge test, an Asthma Control Test (ACT) (maximum score = 25; scores ≤19 indicate poorly controlled asthma), and a final survey that assessed perceptions about asthma management and reduction of environmental triggers. Results: As of October 2022, 147 participants were enrolled in the program, and 52 had consented to and received ≥1 VHV. Forty VHV recipients (77%) were aged <18 years, 40 (77%) were Black people, and 46 (88%) were from families with extremely low or low incomes. Asthma symptoms improved across all participants, with a median increase of 2.4 points on the ACT. Knowledge tests revealed that 86% of participants learned about ≥1 new asthma trigger; a larger percentage of VHV recipients than nonrecipients (68% vs 36%) had an improved knowledge test score postintervention. Compared with preintervention, about three-quarters of participants reported feeling more empowered to self-manage their asthma and a significant improvement in their quality of life postintervention. Conclusions: The program provided virtual asthma education to communities with a high burden of asthma and improved asthma outcomes for participants. Similar virtual models can be used to promote health equity, especially in areas with limited access to health care.
Significant heightened methylation levels of RUNX3 gene promoter in patients with systemic lupus erythematosus
Authors: Ehtesham Naeim , Alesaeidi Samira , Mohammad Zadeh Dorita , Saghaei Mozhdeh , Fakhri Maryam , Bayati Zahra , Esmaeilzadeh Emran , Mosallaei Meysam 
Published: March 2024

Objective Researchers are actively investigating new diagnostic and prognostic biomarkers that offer improved sensitivity and specificity for systemic lupus erythematosus (SLE). One area of interest is DNA methylation changes. Previous studies have shown a connection between the RUNX3 gene dysfunction and SLE. In this study, the focus was on examining the methylation level of the RUNX3 promoter in peripheral blood mononuclear cells (PBMCs) of SLE patients and healthy individuals. Methods A total of 80 individuals diagnosed with SLE from Iran, along with 77 healthy individuals, were included. The methylation levels of the RUNX3 gene in the extracted DNA were evaluated using the MethyQESD method. To determine the diagnostic effectiveness of the RUNX3 promoter methylation level, a receiver operating characteristic (ROC) curve was generated. Results The methylation of the RUNX3 promoter was found to be significantly higher in patients with SLE compared to healthy individuals ( p < .001). This difference in methylation levels was observed between SLE patients and healthy individuals and between SLE patients with renal involvement and those without renal involvement (86.29 ± 10.30 vs 40.28 ± 24.21, p < .001). ROC analyses revealed that the methylation level of the RUNX3 promoter had a diagnostic power of 0.769 [95% CI (0.681–0.814)] for SLE. Additionally, there was a positive correlation between the RUNX3 methylation level and levels of creatinine and C4. Conclusion The findings of this study emphasize the potential use of RUNX3 methylation levels in PBMCs of SLE patients as biomarkers for diagnosing the disease, predicting renal damage, and assessing disease activity.