bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational ambidexterity: A reconceptualization and research agenda for the VUCA international context
Authors: Fernández‐Pérez de la Lastra Susana , Sánchez‐Gardey Gonzalo 
Published: April 2024

AbstractThe literature confirms that organizational ambidexterity (OA) is the key to increasing an organization's prospects for survival and success in an increasingly volatile, uncertain, complex, ambiguous (VUCA) international environment. A critical review of this literature reveals that the conceptualization of OA is disorganized and ambiguous when it establishes and labels relevant aspects of this construct, such as its development and implementation. This study provides a conceptual framework for OA and its dimensions and explains the mechanisms for building and implementing OA. The most important contribution resides in providing research guidelines to improve the consistency and rigour of OA conceptualization in the VUCA international context. To develop this research agenda, we use the VUCA framework, which allows us to identify possible future research and the application of theories and methodologies not previously used. Thus, in general terms, to respond to volatility, studies must be carried out on the agility of organizations. For uncertainty, the topics of knowledge and information management are interesting. To respond to the complexity, topics on restructuring are interesting. And to avoid ambiguity, studies on experimentation would be ideal. Based on this generality, this study proposes multiple future lines of research.
Climate change disclosure and firm value in a frontier market: Exploring the determinants
Authors: Pradhan Rudra P. , Samarakoon S. M. R. K. , Maradana Rana P. , Sahoo Premjit 
Published: April 2024

AbstractWe examine the factors that influence climate change disclosure and its effects on firm value in the context of Sri Lanka. By leveraging data spanning 1031 firm‐year observations from 2017 to 2022, an innovative machine‐learning technique is employed to quantify the level of climate change disclosure within annual corporate reports. Our findings indicate that factors such as firm size, size of the board of directors, the presence of independent and non‐executive directors on the board, and gender diversity of the board positively impact the extent of climate change disclosure. Notably, CEO duality, where the CEO and chairman roles are held by the same individual, demonstrates a negative relationship with climate change disclosure, suggesting that distinct roles can enhance transparency. This underscores the significant role of robust corporate governance practices in promoting environmental transparency and accountability. Additionally, the paper further assesses the implications of climate change disclosure on firm value, revealing that enhanced transparency in climate change disclosure positively impacts firm value.
Exploring the nexus of globalization and natural resource scarcity in driving green technology innovation: Insights from advanced panel data techniques
Authors: Li Jianmin , Yahya Farzan , Waqas Muhammad 
Published: April 2024

AbstractGreen technology innovation (GTI) plays a pivotal role in improving environmental sustainability. Our study fills a significant research gap by investigating how globalization and natural resource depletion (NRD) impact eco‐innovation. Rooted in knowledge spillover and ecological modernization theories, we utilize advanced panel data techniques, an aspect underexplored in empirical studies. Our panel data span G20 countries from 1986 to 2019, further dissected into sub‐panels—BRICS (emerging economies) and G7 (advanced economies). Initial tests reveal cross‐sectional dependencies and slope heterogeneities across all panels, corroborated by Westerlund cointegration test indicating a long‐term equilibrium. Driscoll–Kraay estimator highlights that economic and social globalization significantly drive eco‐innovation, while political globalization deteriorates GTI. The effect of NRD is also negative for G20 and BRICS countries, while G7 economies exhibit lower vulnerability to NRD shocks. Long‐run estimates from CS‐ARDL underscore the positive role of economic globalization in both the short and long run, while the negative role of NRD remains persistent in the long run. Panel quantile regression results prove that the effect of globalization is asymmetric across GTI distribution and varying across underlying groups. NRD, while hindering progress at higher quantiles, supports eco‐innovation at lower quantiles of advanced economies. Panel threshold estimations confirm the positive influence of both globalization and NRD, particularly for highly eco‐innovative nations. These findings bear significant policy implications, charting a path toward sustainable economic growth through the widespread adoption of green technology.
Construct validity, reliability, and threshold value for treatment goals of the Thai version of the 12‐item Psoriatic Arthritis Impact of Disease Questionnaire for patients with psoriatic arthritis
Authors: Chiowchanwisawakit Praveena , Orawongpaisarn Annop , Katchamart Wanruchada 
Published: April 2024

AbstractObjectiveTo determine the construct validity, reliability, and treatment goal threshold of a Thai‐language version of the 12‐item Psoriatic Arthritis Impact of Disease (Thai‐PsAID) questionnaire in patients with psoriatic arthritis (PsA).MethodsThis cross‐sectional study involved administering the proposed Thai‐PsAID to 117 Thai patients with PsA. Reliability was assessed by Cronbach's α test and intraclass correlation coefficient (ICC). Construct validity was assessed using Spearman correlation with clinical disease activity index for psoriatic arthritis (cDAPSA), the Health Assessment Questionnaire (HAQ), EQ‐5D index, and the patient‐acceptable symptom state (PASS). The optimal cutoff score of the Thai‐PsAID for minimal disease activity (MDA) was determined by receiver operating characteristic curves.ResultsParticipants had a mean age of 49.5 years, 61 (52.1%) were female, and the median disease duration was 5 years. The median Thai‐PsAID score was 2.1, with a Cronbach's α coefficient of .95 and an ICC of 0.77. The mean time to complete the Thai‐PsAID was 2.1 min, with no missing data. The Thai‐PsAID score demonstrated a moderate correlation with the cDAPSA, HAQ, and EQ‐5D with indices (Spearman's rho of .64, .54, and −.55, respectively). The cutoff of 2.7 has 81%–84% sensitivity and 69%–85% specificity for classifying patients with MDA, satisfied PASS, and indicating no need to escalate medication.ConclusionsThe Thai‐PsAID is a valid, reliable, and feasible tool for measuring PsA prognosis. A cutoff of 2.7 accurately discriminates MDA and PASS and indicates no need for medication escalation. The Thai‐PsAID may be used as a standalone measure.
Reserving the right to say no? Equilibria around hard trade‐sustainability commitments in power‐asymmetric contexts
Authors: Cezar Rodrigo Fagundes , Montagner Oto Murer Küll 
Published: April 2024

AbstractWhen will stringent sustainability commitments (not) be a stumbling block in the negotiation of trade agreements? Although the existing literature has explored the determinants of the design of sustainability provisions in trade agreements, few works have explored when countries will accept/reject those provisions once their content cannot be changed. Based on insights from game theory, we flesh out the conditions under which there will be an equilibrium in favor of hard sustainability provisions in trade deals. We then present empirical illustrations related to Mexico's participation in the United States–Mexico–Canada Agreement (USMCA) and Brazil's participation in the EU‐Mercosur trade negotiations. Our model shows that (1) fears of partner opportunism, (2) the costs of nonparticipation in trade deals, and (3) costs of adjustments to hard trade‐sustainability commitments are key to understanding whether a compromise can arise on trade and strong sustainability commitments. The model highlights what sorts of concessions ought to be made for negotiations to prosper. The findings point to how the changing structure of trade governance may affect the decision‐making process of Global South countries. The paper concludes with recommendations and avenues for further research.
Multiplex fluorescent amplification‐refractory mutation systemPCRmethod for the detection of 10 genetic defects in Holstein cattle and its comparison with theKASPgenotyping assay
Authors: Khan Md. Yousuf Ali , Dai Dongmei , Su Xin , Tian Jia , Zhou Jiamin , Ma Liqin , Wang Yachun , Wen Wan , Zhang Yi 
Published: April 2024

AbstractThe common deleterious genetic defects in Holstein cattle include haplotypes 1–6 (HH1–HH6), haplotypes for cholesterol deficiency (HCD), bovine leukocyte adhesion deficiency (BLAD), complex vertebral malformation (CVM) and brachyspina syndrome (BS). Recessive inheritance patterns of these genetic defects permit the carriers to function normally, but homozygous recessive genotypes cause embryo loss or neonatal death. Therefore, rapid detection of the carriers is essential to manage these genetic defects. This study was conducted to develop a single‐tube multiplex fluorescent amplification–refractory mutation system (mf‐ARMS) PCR method for efficient genotyping of these 10 genetic defects and to compare its efficiency with the kompetitive allele specific PCR (KASP) genotyping assay. The mf‐ARMS PCR method introduced 10 sets of tri‐primers optimized with additional mismatches in the 3′ end of wild and mutant‐specific primers, size differentiation between wild and mutant‐specific primers, fluorescent labeling of universal primers, adjustment of annealing temperatures and optimization of primer concentrations. The genotyping of 484 Holstein cows resulted in 16.12% carriers with at least one genetic defect, while no homozygous recessive genotype was detected. This study found carrier frequencies ranging from 0.0% (HH6) to 3.72% (HH3) for individual defects. The mf‐ARMS PCR method demonstrated improved detection, time and cost efficiency compared with the KASP method for these defects. Therefore, the application of mf‐ARMS PCR for genotyping Holstein cattle is anticipated to decrease the frequency of lethal alleles and limit the transmission of these genetic defects.
Objective assessment tools in laparoscopic or robotic‐assisted gynecological surgery: A systematic review
Authors: Tesfai Freweini Martha , Nagi Jasleen , Morrison Iona , Boal Matt , Olaitan Adeola , Chandrasekaran Dhivya , Stoyanov Danail , Lanceley Anne , Francis Nader 
Published: April 2024

AbstractIntroductionThere is a growing emphasis on proficiency‐based progression within surgical training. To enable this, clearly defined metrics for those newly acquired surgical skills are needed. These can be formulated in objective assessment tools. The aim of the present study was to systematically review the literature reporting on available tools for objective assessment of minimally invasive gynecological surgery (simulated) performance and evaluate their reliability and validity.Material and methodsA systematic search (1989–2022) was conducted in MEDLINE, Embase, PubMed, Web of Science in accordance with PRISMA. The trial was registered with the Prospective Register of Systematic Reviews (PROSPERO) ID: CRD42022376552. Randomized controlled trials, prospective comparative studies, prospective single‐group (with pre‐ and post‐training assessment) or consensus studies that reported on the development, validation or usage of assessment tools of surgical performance in minimally invasive gynecological surgery, were included. Three independent assessors assessed study setting and validity evidence according to a contemporary framework of validity, which was adapted from Messick's validity framework. Methodological quality of included studies was assessed using the modified medical education research study quality instrument (MERSQI) checklist. Heterogeneity in data reporting on types of tools, data collection, study design, definition of expertise (novice vs. experts) and statistical values prevented a meaningful meta‐analysis.ResultsA total of 19 746 titles and abstracts were screened of which 72 articles met the inclusion criteria. A total of 37 different assessment tools were identified of which 13 represented manual global assessment tools, 13 manual procedure‐specific assessment tools and 11 automated performance metrices. Only two tools showed substantive evidence of validity. Reliability and validity per tool were provided. No assessment tools showed direct correlation between tool scores and patient related outcomes.ConclusionsExisting objective assessment tools lack evidence on predicting patient outcomes and suffer from limitations in transferability outside of the research environment, particularly for automated performance metrics. Future research should prioritize filling these gaps while integrating advanced technologies like kinematic data and AI for robust, objective surgical skill assessment within gynecological advanced surgical training programs.
Maintaining influence through economic statecraft: Australia's response to China's presence in the Pacific region
Authors: Yoshimatsu Hidetaka , Maso Roselyn 
Published: April 2024

AbstractAustralia has historically been a prominent diplomatic partner for the Pacific Island countries, providing development assistance to support their social and economic progress. China gradually heightened its political and economic influence in the Pacific area by integrating the region into its Belt and Road Initiative. This development has encouraged scholars to examine Australia's diplomatic engagements in the Pacific region in response to China's growing presence. This article approaches this issue by using the concept of economic statecraft as an analytical tool. It argues that Australia's reactions to China's presence through the infusion of strategic motivations into foreign aid and the use of multilateral agreements and initiatives can be seen as positive economic statecraft with two characterizations: emulation of China's successful strategies and differentiation from Chinese approaches through the incorporation of multilateral and ideational methods.
Copper: From enigma to therapeutic target for neurological disorder
Authors: Patwa Jayant , Flora Swaran Jeet Singh 
Published: April 2024

AbstractNeurological disorders (NDs) have a negative impact on the lives of individuals. There could be two explanations for this: unclear aetiology and lack of effective therapy. However, research in the past few years has revealed the role of bio‐metals dyshomeostasis in NDs. The imbalance in copper (Cu) concentration may be one of the main causative factors in NDs. In this review, we have discussed the role of Cu in NDs, especially Alzheimer's disease (AD), including the molecular mechanisms involved in Cu‐associated NDs like oxidative stress, neuroinflammation, and protein misfolding. We have also summarized the recent Cu‐targeting approaches and highlighted the in vitro and in vivo studies recently being reported on the subject. Based on the earlier published reports, it could be speculated that the Cu targeting strategy might be an interesting and potential therapeutic approach for NDs. Various difficulties must be overcome to develop safe and efficient Cu‐targeting medications for NDs.
Cariprazine as a maintenance therapy in the prevention of mood episodes in adults with bipolar I disorder
Authors: McIntyre Roger S. , Davis Bethany , Rodgers Jane , Rekeda Ludmyla , Adams Julie , Yatham Lakshmi N. 
Published: April 2024

AbstractIntroductionCariprazine treats acute manic and depressive episodes in bipolar I disorder (BP‐I), but its efficacy in preventing relapse of mood episode remains unknown.MethodsIn this phase 3b, double‐blind, placebo‐controlled study, patients with BP‐I with acute manic or depressive episodes (each with/without mixed features), were treated with cariprazine 3.0 mg/day during a 16‐week open‐label treatment period; those who achieved stable remission within 8 weeks and remained stable for at least another 8 weeks were randomized to receive cariprazine 1.5 or 3.0 mg per day or placebo in the double‐blind treatment period for up to 39 weeks. The primary efficacy endpoint was time to relapse of any mood episode. Adverse events (AEs) were assessed.ResultsPatients (440/896) enrolled in the open‐label treatment period achieved stability criteria and were randomized to receive cariprazine 3.0 mg/day (n = 148), cariprazine 1.5 mg/day (n = 147), or placebo (n = 145) in the double‐blind treatment period. Relapse rates were 17.9%, 16.8%, and 19.7% in the cariprazine 3.0 mg/day, cariprazine 1.5 mg/day, and placebo groups, respectively. Neither dose of cariprazine was more effective than placebo on the primary outcome (3.0 mg/day: HR = 0.89, [95% CI: 0.5, 1.5]; 1.5 mg/day: HR = 0.83, 95% CI [0.5, 1.4]). The most frequently reported AEs (≥5%) were akathisia, headache, insomnia, and nausea in the open‐label treatment period and increased weight and insomnia in the double‐blind treatment period. In the open‐label and double‐blind treatment periods, 7.5% and 1.6% of patients experienced an AE leading to discontinuation.ConclusionCariprazine was not superior to placebo in the prevention of relapses in this study. Relapse rates were unusually low in the placebo group. Cariprazine was well‐tolerated.
Autistic and non‐autistic transgender youth are similar in gender development and sexuality phenotypes
Authors: Fischbach Abigail L. , Hindenach Andy , van der Miesen Anna I. R. , Yang Ji Seung , Buckley Olivia J. , Song Minneh , Campos Laura , Strang John F. 
Published: April 2024

AbstractIncreasing rhetoric regarding the common intersection of autism and gender diversity has resulted in legislation banning autistic transgender youth from accessing standard of care supports, as well as legislative efforts banning all youth gender care in part justified by the proportional over‐occurrence of autism. Yet, no study has investigated whether autistic and non‐autistic transgender youth present fundamentally different gender‐related phenotypes. To address this gap, we extensively characterized autism, gender diversity, and sexuality among autistic and non‐autistic transgender binary youth (N = 66, Mage = 17.17, SDage = 2.12) in order to investigate similarities and/or differences in gender and sexuality phenotypes. Neither autism diagnostic status nor continuous autistic traits were significantly related to any gender or sexuality phenotypes. These findings suggest that the developmental and experiential features of gender diversity are very similar between autistic and non‐autistic transgender adolescents. Future research is needed to determine whether the similarity in profiles is maintained over time into adulthood.
A safety and efficacy study of allogeneic haematopoietic stem cell transplantation for refractory and relapsed T‐cell acute lymphoblastic leukaemia/lymphoblastic lymphoma patients who achieved complete remission after autologous CD7 chimeric antigen receptor T‐cell therapy
Authors: Cao Xing‐yu , Zhang Jian‐ping , Lu Yue , Zhao Yan‐li , Liu De‐yan , Xiong Min , Sun Rui‐juan , Wei Zhi‐jie , Zhou Jia‐rui , Zhang Xian , Yang Jun‐fang , Li Jingjing , Lu Peihua 
Published: April 2024

SummaryCD7‐targeted chimeric antigen receptor T‐cell (CAR‐T) therapy has shown promising initial complete remission (CR) rates in patients with refractory or relapsed (r/r) T‐cell acute lymphoblastic leukaemia and lymphoblastic lymphoma (T‐ALL/LBL). To enhance the remission duration, consolidation with allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is considered. Our study delved into the outcomes of 34 patients with r/r T‐ALL/LBL who underwent allo‐HSCT after achieving CR with autologous CD7 CAR‐T therapy. These were compared with 124 consecutive T‐ALL/LBL patients who received allo‐HSCT in CR following chemotherapy. The study revealed that both the CAR‐T and chemotherapy cohorts exhibited comparable 2‐year overall survival (OS) (61.9% [95% CI, 44.1–78.1] vs. 67.6% [95% CI, 57.5–76.9], p = 0.210), leukaemia‐free survival (LFS) (62.3% [95% CI, 44.6–78.4] vs. 62.0% [95% CI, 51.8–71.7], p = 0.548), non‐relapse mortality (NRM) rates (32.0% [95% CI, 19.0–54.0] vs. 25.3% [95% CI, 17.9–35.8], p = 0.288) and relapse incidence rates (8.8% [95% CI, 3.0–26.0] vs. 15.8% [95% CI, 9.8–25.2], p = 0.557). Patients aged ≤14 in the CD7 CAR‐T group achieved high 2‐year OS and LFS rates of 87.5%. Our study indicates that CD7 CAR‐T therapy followed by allo‐HSCT is not only effective and safe for r/r T‐ALL/LBL patients but also on par with the outcomes of those achieving CR through chemotherapy, without increasing NRM.
Proteomic profiling of circulating β‐thalassaemia/haemoglobin E extra‐cellular vesicles reveals that association with immunoglobulin induces membrane vesiculation
Authors: Phongpao Kunwadee , Pholngam Nuttanan , Chokchaichamnankit Daranee , Nuamsee Khanita , Praneetponkang Rattanaporn , Ounjai Puey , Paiboonsukwong Kittiphong , Siwaponanan Panjaree , Pattanapanyasat Kovit , Svasti Jisnuson , Srisomsap Chantragan , Weeraphan Churat , Chaichompoo Pornthip , Svasti Saovaros 
Published: April 2024

SummarySplenectomised β‐thalassaemia/haemoglobin E (HbE) patients have increased levels of circulating microparticles or medium extra‐cellular vesicles (mEVs). The splenectomised mEVs play important roles in thromboembolic complications in patients since they can induce platelet activation and endothelial cell dysfunction. However, a comprehensive understanding of the mechanism of mEV generation in thalassaemia disease has still not been reached. Thalassaemic mEVs are hypothesised to be generated from cellular oxidative stress in red blood cells (RBCs) and platelets. Therefore, a proteomic analysis of mEVs from splenectomised and non‐splenectomised β‐thalassaemia/HbE patients was performed by liquid chromatography with tandem mass spectrometry. A total of 171 proteins were identified among mEVs. Interestingly, 72 proteins were uniquely found in splenectomised mEVs including immunoglobulin subunits and cytoskeleton proteins. Immunoglobulin G (IgG)‐bearing mEVs in splenectomised patients were significantly increased. Furthermore, complement C1q was detected in both mEVs with IgG binding and mEVs without IgG binding. Interestingly, the percentage of mEVs generated from RBCs with IgG binding was approximately 15–20 times higher than the percentage of RBCs binding with IgG. This suggested that the vesiculation of thalassaemia mEVs could be a mechanism of RBCs to eliminate membrane patches harbouring immune complex and may consequently prevent cells from phagocytosis and lysis.