bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Congress Beat: How the Structure of News Shapes Coverage of Congressional Action
Authors: Curry James M , Lee Frances E , Oldham Robert L 
Published: March 2024

Abstract
Scholars have long criticized media coverage of Congress for its focus on conflict over policy substance. To uncover the drivers of this focus, we examine news coverage of the congressional response to COVID-19. We select the COVID-19 response as an extreme case of Congress coalescing quickly to address a major national crisis in an almost entirely bipartisan way. Our study confirms prior research documenting a media preference for conflict narratives, even in this case. But we also find that the practice of beat reporting on Congress is, itself, a key factor underlying the dominance of news about conflict. A steady volume of reporting on an institution that acts quickly when there is agreement but slowly when there is disagreement gives rise to a large-scale imbalance favoring stories about conflict. Because conflict necessarily takes up more of Congress's time, it dominates beat reporting on the institution. We find this imbalance is more pronounced in national newspapers, which produce a relatively constant volume of reporting by journalists assigned to the “Congress beat,” than in broadcast television news, which reports on Congress episodically and often only in response to legislative enactments. Our findings shed new light on public and scholarly perceptions of the institution's performance.
Age-associated sleep spindle characteristics in Duchenne muscular dystrophy
Authors: Simon Katharine C , Cadle Chelsea , Nakra Neal , Nagel Marni C , Malerba Paola 
Published: March 2024

Abstract
Brain oscillations of non-rapid eye movement sleep, including slow oscillations (SO, 0.5–1.5 Hz) and spindles (10–16 Hz), mirror underlying brain maturation across development and are associated with cognition. Hence, age-associated emergence and changes in the electrophysiological properties of these rhythms can lend insight into cortical development, specifically in comparisons between pediatric populations and typically developing peers. We previously evaluated age-associated changes in SOs in male patients with Duchenne muscular dystrophy (DMD), finding a significant age-related decline between 4 and 18 years. While primarily a muscle disorder, male patients with DMD can also have sleep, cognitive, and cortical abnormalities, thought to be driven by altered dystrophin expression in the brain. In this follow-up study, we characterized the age-associated changes in sleep spindles. We found that age-dependent spindle characteristics in patients with DMD, including density, frequency, amplitude, and duration, were consistent with age-associated trends reported in the literature for typically developing controls. Combined with our prior finding of age-associated decline in SOs, our results suggest that SOs, but not spindles, are a candidate intervention target to enhance sleep in patients with DMD.
Distinguishing Cophylogenetic Signal from Phylogenetic Congruence Clarifies the Interplay Between Evolutionary History and Species Interactions
Authors: Perez-Lamarque Benoît , Morlon Hélène 
Published: March 2024

Abstract
Interspecific interactions, including host–symbiont associations, can profoundly affect the evolution of the interacting species. Given the phylogenies of host and symbiont clades and knowledge of which host species interact with which symbiont, two questions are often asked: “Do closely related hosts interact with closely related symbionts?” and “Do host and symbiont phylogenies mirror one another?.” These questions are intertwined and can even collapse under specific situations, such that they are often confused one with the other. However, in most situations, a positive answer to the first question, hereafter referred to as “cophylogenetic signal,” does not imply a close match between the host and symbiont phylogenies. It suggests only that past evolutionary history has contributed to shaping present-day interactions, which can arise, for example, through present-day trait matching, or from a single ancient vicariance event that increases the probability that closely related species overlap geographically. A positive answer to the second, referred to as “phylogenetic congruence,” is more restrictive as it suggests a close match between the two phylogenies, which may happen, for example, if symbiont diversification tracks host diversification or if the diversifications of the two clades were subject to the same succession of vicariance events. Here we apply a set of methods (ParaFit, PACo, and eMPRess), whose significance is often interpreted as evidence for phylogenetic congruence, to simulations under 3 biologically realistic scenarios of trait matching, a single ancient vicariance event, and phylogenetic tracking with frequent cospeciation events. The latter is the only scenario that generates phylogenetic congruence, whereas the first 2 generate a cophylogenetic signal in the absence of phylogenetic congruence. We find that tests of global-fit methods (ParaFit and PACo) are significant under the 3 scenarios, whereas tests of event-based methods (eMPRess) are only significant under the scenario of phylogenetic tracking. Therefore, significant results from global-fit methods should be interpreted in terms of cophylogenetic signal and not phylogenetic congruence; such significant results can arise under scenarios when hosts and symbionts had independent evolutionary histories. Conversely, significant results from event-based methods suggest a strong form of dependency between hosts and symbionts evolutionary histories. Clarifying the patterns detected by different cophylogenetic methods is key to understanding how interspecific interactions shape and are shaped by evolution.
Synchronizing Automatic Gain Control in Bilateral Cochlear Implants Mitigates Dynamic Localization Deficits Introduced by Independent Bilateral Compression
Authors: Pastore M. Torben , Pulling Kathryn R. , Chen Chen , Yost William A. , Dorman Michael F. 
Published: March 2024

Objectives:
The independence of left and right automatic gain controls (AGCs) used in cochlear implants can distort interaural level differences and thereby compromise dynamic sound source localization. We assessed the degree to which synchronizing left and right AGCs mitigates those difficulties as indicated by listeners’ ability to use the changes in interaural level differences that come with head movements to avoid front-back reversals (FBRs).

Design:
Broadband noise stimuli were presented from one of six equally spaced loudspeakers surrounding the listener. Sound source identification was tested for stimuli presented at 70 dBA (above AGC threshold) for 10 bilateral cochlear implant patients, under conditions where (1) patients remained stationary and (2) free head movements within ±30° were encouraged. These conditions were repeated for both synchronized and independent AGCs. The same conditions were run at 50 dBA, below the AGC threshold, to assess listeners’ baseline performance when AGCs were not engaged. In this way, the expected high variability in listener performance could be separated from effects of independent AGCs to reveal the degree to which synchronizing AGCs could restore localization performance to what it was without AGC compression.

Results:
The mean rate of FBRs was higher for sound stimuli presented at 70 dBA with independent AGCs, both with and without head movements, than at 50 dBA, suggesting that when AGCs were independently engaged they contributed to poorer front-back localization. When listeners remained stationary, synchronizing AGCs did not significantly reduce the rate of FBRs. When AGCs were independent at 70 dBA, head movements did not have a significant effect on the rate of FBRs. Head movements did have a significant group effect on the rate of FBRs at 50 dBA when AGCs were not engaged and at 70 dBA when AGCs were synchronized. Synchronization of AGCs, together with head movements, reduced the rate of FBRs to approximately what it was in the 50-dBA baseline condition. Synchronizing AGCs also had a significant group effect on listeners’ overall percent correct localization.

Conclusions:
Synchronizing AGCs allowed for listeners to mitigate front-back confusions introduced by unsynchronized AGCs when head motion was permitted, returning individual listener performance to roughly what it was in the 50-dBA baseline condition when AGCs were not engaged. Synchronization of AGCs did not overcome localization deficiencies which were observed when AGCs were not engaged, and which are therefore unrelated to AGC compression.
Fixation techniques for periprosthetic femur fractures around total knee arthroplasty: a systematic review
Authors: Chan Peter Y.W. , Hinkle Andrew , Huo Michael H. 
Published: March 2024

There is no consensus regarding the treatment algorithm for the fixation of periprosthetic femur fractures (PFFs) around a total knee arthroplasty (TKA). Established methods of fracture fixation include locking plate (LP) or retrograde intramedullary nail (RIN) techniques. Newer fixation methods include the dual plate (DP) and the nail-plate combination (NPC) techniques. The purpose of this study is to review the literature on the outcomes of PFF fixation following TKAs over the past two decades. A systematic review was undertaken in the MEDLINE, Embase, and Cochrane databases in accordance with the PRISMA standards. Selection criteria included: patient cohort > 5 cases and minimum follow-up of 12 mo. Risk of bias was assessed with the Joanna Briggs Institute Critical Appraisal Checklists for Cohort Studies and Case Series. Combined data analysis was performed with linear models and linear mixed effect models to compare the post-operative outcomes of the LP, RIN, and DP techniques. Our search identified 1086 studies and 31 were selected for final analysis. The number of the studies for the LP, RIN, DP, and NPC techniques were 23, 15, 4, and 1, respectively. There were no differences in the time to union, Knee Society Knee Score, or range of motion among the LP, RIN, and DP techniques. Although analysis did not demonstrate significant differences, it is limited by the lack of the available studies using the DP technique. Additionally, only one study for the NPC technique was retained after screening and data analysis was therefore not possible.
Is Immobilization Technique Associated With Postoperative Pubic Rami Diastasis Following Bladder Exstrophy Closure?
Authors: Annabell Lucas , Lee Ted , Barnett Samuel , Ralston Katelyn , Lee Richard , Borer Joseph G. , Kim Young-jo 
Published: March 2024

Objective:
Pelvic osteotomies relieve tension of the bladder and fascial closures during bladder exstrophy repair. Multiple techniques for postoperative immobilization of the pelvis and lower extremities have been described. The primary aim of this study was to assess differences in short and long-term changes in pubic rami diastasis when comparing Bryant traction to spica cast immobilization. Secondary aims included a comparison of length of stay, skin-related complications, and urologic outcomes.

Methods:
We performed a single-institutional retrospective review of bladder exstrophy patients younger than 18 months of age who underwent posterior pelvic osteotomy and bladder exstrophy closure from April 2005 to April 2020. Short-term and long-term pubic rami diastasis were defined as postoperative measurements ≤6 months and ≥12 months, respectively. Secondary outcomes included length of stay, pressure ulcer, skin rash/abrasion, urethrocutaneous fistula, and bladder or fascial dehiscence rates. Multivariable logistic regression assessed for an association between immobilization type and degree of diastasis while controlling for age at the time of diastasis measurement and sex.

Results:
Fifteen patients underwent Bryant traction and 36 patients underwent spica cast immobilization. In both the short-term and long-term, there was a greater reduction in pubic diastasis in the spica cast group (P= 0.002 and P= 0.05, respectively). After adjustments, there were higher odds of having a greater reduction in pubic rami diastasis in both the short-term (odds ratio: 2.71, 95% CI: 1.52-4.86, P= 0.001) and long-term (odds ratio: 2.41, 95% CI: 1.00-5.80, P= 0.05). Length of stay was significantly higher in Bryant’s traction group (26 vs 19 d, P< 0.001). Rates of pressure ulcers were higher in the Bryant traction group (26.7% vs 0%, P= 0.005). Rates of skin rash/abrasions, urethrocutaneous fistula, and bladder/fascial dehiscence did not differ.

Conclusions:
Spica cast immobilization is a safe and effective immobilization method. Compared with Bryant traction, spica cast immobilization was associated with a greater reduction in postoperative pubic diastasis both short and long-term, along with a shorter length of hospitalization and reduced rate of pressure ulcers.

Level of Evidence:
Level III—therapeutic study.
Treatment of Hip Displacement in Children With Cerebral Palsy: A 5-year Comparison of Proximal Femoral Osteotomy and Combined Femoral-Pelvic Osteotomy in 163 Children
Authors: Kiapekos Nikolaos , von Heideken Johan , Broström Eva , Hägglund Gunnar , Åstrand Per 
Published: March 2024

Background:
This study compared the 5-year outcomes of isolated proximal femoral varus osteotomy (FO) and combined proximal femoral varus and pelvic osteotomy (FPO) for the treatment of hip displacement in children with cerebral palsy (CP) in Sweden, focusing on the number of reoperations and residual hip displacement.

Methods:
The study included 163 children with a 5-year follow-up after FO or FPO in the national Swedish CP surveillance program, CPUP. Descriptive statistics and univariate and multivariate Cox regression analyses were used to identify whether the age at surgery, sex, Gross Motor Function Classification System level, CP dominant symptom, hip migration percentage (MP), type of surgery (unilateral/bilateral), and history of soft tissue hip surgery were related to the 5-year outcomes after surgery. Failure after hip surgery was defined as a skeletal reoperation involving the hip and/or MP >50%.

Results:
During the period 2001 to 2017, 163 children (65 girls) underwent 246 femoral and/or pelvic osteotomies (154 FO, 47 bilaterally; 92 FPO, 16 bilaterally) and had a 5-year follow-up; 95 and 74 children had ≥1 FO or FPO as the primary skeletal surgery, respectively. The mean preoperative MP (51%±18% for FO and 59%±17% for FPO, P=0.001) and age at surgery (6.2±2.5 years for FO and 7.3±2.8 years for FPO, P=0.014) differed between procedures. At the 5-year follow-up, 5 hips (5%) had reoperations and 5 hips (5%) had radiological failure among the 92 FPOs, and 33 (21%) had reoperations and 14 (9%) radiological failure among the 154 FOs. The difference in outcome failure rate was significant (P<0.001). Multivariate Cox regression analysis showed a lower risk for failure with FPO [hazard ratio (HR)=0.32, 95% CI: 0.15-0.68] compared with FO. A higher preoperative MP increased the risk for outcome failure (HR=1.21, 95% CI: 1.15-1.36 for each 5% increment).

Conclusions:
FPO had a higher mean preoperative MP but a lower 5-year outcome failure rate compared with FO. A higher preoperative MP was associated with an increased risk of failure.

Level of Evidence:
Level II—prospective comparative study.
Predicting Skeletal-related Events Using SINS
Authors: Nakanishi Kazuo , Hijikata Yasukazu , Uchino Kazuya , Sugimoto Yoshihisa , Iba Hideaki , Watanabe Seiya , Mitani Shigeru 
Published: March 2024

Study Design.
Predictive study utilized retrospectively collected data.

Objective.
The primary objective was to evaluate the predictive association between the Spine Instability Neoplastic Score (SINS) and Skeletal-related events (SREs). Secondary objectives included examining characteristics of cases with SINS ≤ 6 among those who developed SRE and evaluating the impact of additional predictors on prediction accuracy.

Summary of Background Data.
Advances in cancer treatment have prolonged the lives of cancer patients, emphasizing the importance of maintaining quality of life. SREs from metastatic spinal tumors significantly impact the quality of life. However, currently, there is no scientifically established method to predict the occurrence of SRE. SINS, developed by the Spine Oncology Study Group, assesses spinal instability using six categories. Therefore, the predictive performance of SINS for SRE occurrence is of considerable interest to clinicians.

Methods.
This predictive study utilized retrospectively collected data from a single-center registry comprising over 1000 patients with metastatic spinal tumors. SINS and clinical data were collected. Logistic regression was used to create a prediction equation for SRE using SINS. Additional analyses explored factors associated with SRE in patients with SINS ≤ 6.

Results.
The study included 1041 patients with metastatic spinal tumors. SRE occurred in 121 cases (12%). The prediction model for SRE using SINS demonstrated an area under the curve (AUC) of 0.832. Characteristics associated with SRE included lower female prevalence, surgeries to primary sites, bone metastases to nonspinal sites, and metastases to other organs. A post hoc analysis incorporating additional predictors improved the AUC to 0.865.

Conclusions.
The SINS demonstrated reasonable predictive performance for SRE within one month of the initial visit. Incorporating additional factors improved prediction accuracy. The study emphasizes the need for a comprehensive clinical prediction model for SRE in metastatic spinal tumors.
Combinatorial Inhibition of Complement Factor D and BCL2 for Early-Onset Colorectal Cancer
Authors: Rahman Shahrose , Affleck IV Arthur , Ruhl Rebecca , Patel Ranish K. , Gao Lina , Brinkerhoff Brian , Tsikitis V. Liana , Anand Sudarshan 
Published: March 2024

BACKGROUND:
The tumor immune microenvironment is distinct between early-onset and late-onset colorectal cancer which facilitates tumor progression. We previously identified several genes, including complement factor D, as having increased expression in patients with early-onset colorectal cancer.

OBJECTIVE:
This study aimed to assess and validate differential expression of immune genes in early and late-onset colorectal cancer. We also aimed to test known drugs targeting genes increased in early-onset colorectal cancer in preclinical mouse models.

DESIGN:
Retrospective cohort study with analysis performed using tumor RNA from formalin-fixed paraffin-embedded, cell culture and immunohistochemistry to validate gene expression and gene function. In vivo preclinical tumor study to assess drug efficacy.

SETTINGS:
Oregon Colorectal Cancer Registry was queried to find patients with colorectal cancer.

SUBJECTS:
Study included 67 patients with early and 54 patients with late-onset colorectal cancer.

INTERVENTIONS:
Preclinical animal models using the HCT-116 colon cancer cell line were treated with complement factor D inhibitor danicopan and BCL2 inhibitor venetoclax, or with vehicle controls.

MAIN OUTCOME MEASURES:
Elevated RNA signatures using NanoString data was evaluated from the retrospective cohort. When inhibiting these markers in the mouse preclinical model, tumor volume and weight were the main outcome measures.

RESULTS:
After updating our sample size from our previously published data, we found that complement factor D and BCL2, genes with known function and small molecule inhibitors, are elevated in patients with early-onset colorectal cancer. When inhibiting these markers with drugs danicopan and venetoclax in a mouse model, we found that the combination of these drugs decreased tumor burden but also resulted in toxicity.

LIMITATIONS:
This study is limited by small sample size and a subcutaneous tumor model.

CONCLUSIONS:
Combinatorial inhibition of early-onset associated genes complement factor D and BCL2 slows growth of early-onset colorectal cancer in a mouse preclinical model. See Video Abstract.
Systematic Review of Neoadjuvant Immunotherapy for Mismatch Repair Deficient Locally Advanced Colon Cancer: An Emerging Strategy
Authors: Loria Anthony , Ammann Allison M. , Olowokure Olugbenga O. , Paquette Ian M. , Justiniano Carla F. 
Published: March 2024

BACKGROUND:
In April 2023, the National Comprehensive Cancer Network endorsed neoadjuvant immunotherapy for select patients with non-metastatic mismatch repair deficient colon cancer. Approximately 15% of incident colon cancers are mismatch repair deficient, resulting in a distinct molecular subtype with high microsatellite instability that is responsive to immune checkpoint inhibition.

OBJECTIVE:
To describe the existing evidence supporting neoadjuvant immunotherapy for mismatch repair deficient, microsatellite unstable non-metastatic colon cancer.

DATA SOURCES:
A medical librarian performed PubMed, Embase, and Web of Science searches most recently on April 24, 2023. The PubMed search was re-run on September 26, 2023, to identify any additional studies published during the interim from April to September 2023.

STUDY SELECTION:
Two authors screened titles and abstracts in the published studies. The inclusion criteria were (1) English-language; (2) adults with primary cancer of the colon; (3) non-metastatic disease; (4) neoadjuvant immunotherapy; (5) reporting on 10 or more cases.

INTERVENTION:
Neoadjuvant immunotherapy.

MAIN OUTCOME MEASUREs:
Safety (Grade 3+ treatment related adverse events) and efficacy (complete pathologic responses).

RESULTS:
From 7,691 studies identified, 6,370 were screened, and 8 included. Various agents, dosing regimens, and treatment durations were employed, with durations of immunotherapy ranging from 1-16 cycles. Complete R0 resections were consistently achieved in 98%-100% of resections. Of patients who received neoadjuvant immunotherapy and underwent resection, 50%-91% had ypT0N0 pathology. The safety profiles were generally favorable, with Grade 1-2 treatment-related adverse events (mostly immune-related) during immunotherapy reported in 22.2%-70% of patients. Postoperative complications following neoadjuvant immunotherapy were reassuring, with no severe complications reported.

LIMITATIONS:
Small number of heterogeneous and uncontrolled studies precluding a meta-analysis.

CONCLUSIONS:
Neoadjuvant immune checkpoint inhibition is associated with high rates of pathologic complete responses in locally advanced colon cancer. The literature is limited, particularly for postoperative outcomes, and more studies are needed to understand the safety and positioning of these regimens in the neoadjuvant context.