bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Operational facilities and Hygienic Practices of Abattoirs and Butcher shops in Ethiopia: Implications for Consumer’s Health
Authors: Yimana Muhabaw , Hassen Awol 
Published: March 2024

Abstract
Most meat-borne outbreaks are usually attributed to contamination in the meat supply chain due to poor handling practices and incomplete operational facilities. A cross-sectional study, using a structured questionnaire interview and observational checklist, was conducted to assess the hygienic practices of workers from abattoir and butcher shops and the operational facilities in the area. A total of 286 randomly selected workers were participated in this study. At the abattoirs, isolation pen for sick animals, stunning boxes, separate rooms for carcass and offal, cooling equipment and laboratories were missing facilities. Inhumane stunning, inadequate hand washing, insufficient trained workers, irregular medical checkups, and unspecified roles in the slaughtering process were practices that led to unhygienic handling of meat. At butcher shops, hand washing after meat handling (97.9%), storing leftover meat in refrigerators (80.9 %), concrete/tile floors (94.5%), and white-painted walls were good practices observed. Displaying meat at room temperature, wrapping meat with plastic bags and newspapers and untrained workers (82.6%) were practices that could compromise the quality of meat. Training was the only factor significantly associated with the hygienic practice of workers both at abattoirs (p=0.023) and butcher shops (p=0.012). Our study identified substandard facilities and unhygienic practices both at abattoirs and butcher shops that lead to microbial contamination of meat, which could be enhanced through improving operational facilities, training, and implementation of quality control systems.
Electroassisted selective and stable CO2 hydrogenation to methanol on CuZnAl catalyst beyond conventional thermal process
Authors: Zhang Suojiang , Yang Qiang , Yan Hanwen , Li Jie , Zhang Guoliang , Wang Luming , Wang Gang , Li Chunshan 
Published: March 2024

Abstract

Effective strategy is strongly required for efficient CO2 hydrogenation to methanol on Cu-based catalyst, considering the great significance of recycling and upgrading this greenhouse gas. Here, we report an electroassisted catalytic process for CO2 hydrogenation to methanol on CuZnAl catalyst beyond conventional thermal process. The electric field drives the formation of Cu steps with stacking faults and disordered ZnO overlayers, generation of specific Cu-ZnO (Cu2O) interfaces through their strong interactions, preferential exposure of Cu2O (110) facet and controllable balance of Cu0/Cu+ species in catalyst. These unique characteristics consequentially trigger the excellent redox properties of Cu species, CO2/CO adsorption-desorption capacities, and thermal tolerance, facilitating the formation of crucial HCOO* and CH3O* intermediates and durable catalytic stability. Only provided 0.5 W electric power can supremely promote the CO2 conversion and methanol selectivity by around 22% and 28% compared with the conventional thermal catalytic process, rendering it a promising technology for CO2 transformation.
Effect of changes in motor skill induced by educational video program to decrease lower- limb joint load during cutting maneuvers: based on musculoskeletal modeling
Authors: Kim Sungmin , So Jiho , Jeon Youngju , Moon Jeheon 
Published: March 2024

Abstract
Background: This study investigated the effects of changes in motor skills from an educational video program on the kinematic and kinetic variables of the lower extremity joints and knee ligament load.
Methods: Twenty participants (age: 22.2±2.60 y; height: 1.70±6.2 m; weight: 25.4±7.01 kg) were instructed to run at 4.5±0.2 m/s from a 5 m distance posterior to the force plate, land their foot on the force plate, and perform the cutting maneuver on the left. The educational video program for cutting maneuvers consisted of preparatory posture, foot landing orientation, gaze and trunk directions, soft landing, and eversion angle. The measured variables were the angle, angular velocity of lower extremity joints, ground reaction force (GRF), moment, and anterior cruciate ligament (ACL) and medial collateral ligament (MCL) forces through musculoskeletal modeling.
Results: After the video feedback, the hip joint angles increased in flexion, abduction, and external rotation (p > 0.05), and the angular velocity increased in extension (p = 0.006). The ankle joint angles increased in dorsiflexion (p = 0.021), and the angular velocity decreased in dorsiflexion (p = 0.002) but increased in abduction (p = 0.002). The GRF increased in the anterior-posterior and medial-lateral directions and decreased vertically (p > 0.05). The hip joint moments decreased in extension and external rotation (p > 0.05) but increased in adduction (p = 0.038). The knee joint moments were decreased in extension, adduction, and external rotation (p > 0.05). The abduction moment of the ankle joint decreased (p = 0.000). There were differences in the support zone corresponding to 64‒87% of the hip frontal moment (p = 0.001) and 32‒100% of the hip horizontal moment (p < 0.001) and differences corresponding to 32‒100% of the knee frontal moment and 21‒100% of the knee horizontal moment (p < 0.001). The GRF varied in the support zone at 44‒95% in the medial-lateral direction and at 17‒43% and 73‒100% in the vertical direction (p < 0.001).
Conclusions: Injury prevention feedback reduced the load on the lower extremity joints during cutting maneuvers, which reduced the knee ligament load, mainly on the MCL.
Open Health Knowledge Management Platform: A Comprehensive Evaluation of a Data-centric Approach for Patient Care and Research
Authors: Schreiweis Björn , Kinast Benjamin , Ulrich Hannes , Pinto Santiago Pazmino , Bergh Björn 
Published: March 2024

Abstract
Background
In the evolving landscape of healthcare, the fragmented IT environment poses challenges to data utilization. This paper introduces the Open Health Knowledge Management Platform, designed to overcome data fragmentation, heterogeneity, and interoperability challenges. The platform aims to bridge the gap between research and patient care, showcased through real-world scenarios, emphasizing seamless data integration and collaborative research. The University Hospital Schleswig-Holstein's (UKSH) diverse IT landscape is a specific focus, and the platform proposes a solution to the separation between patient care and research, aligning with the Medical Informatics Initiative’s goal of efficient, unified data access.
Methods
The study evaluates the "open health knowledge management platform" designed to target data silos and interoperability issues. Utilizing the Framework for Evaluation in Design Science Research (FEDS), three hypotheses guide scenario-based evaluations: data integration, data quality, and scalability. The platform's technical evaluation, centered on interoperability, single-point-of-truth, and real-world scenarios, follows the FEDS framework and ISO/IEC 25000 standard. Three scenarios cardiology, neurology, and radiology are selected for a naturalistic, qualitative evaluation, showcasing the platform's effectiveness. The FEDS components Problem, Solution, Evaluation, and Communication guide a comprehensive understanding and dissemination of the platform's impact. The system architecture emphasizes interoperability, a single point of truth, and use case agnosticism.
Results
The Open Health Knowledge Management Platform has undergone successful evaluation at UKSH. Demonstrating adaptability across diverse data formats like HL7 V2 messages, CSV exports, and BIDS-formatted EEG data, the platform showed its efficacy in certain real-world scenarios of cardiology, neurology and radiology. Our evaluation confirms the platform’s capacity to bridge gaps between patient care and research data utilization, facilitating collaboration and advancing clinical decision-making.
Conclusion
Our evaluation of the open health knowledge management platform at UKSH reveals its capabilities in tackling data fragmentation, enhancing interoperability, and enabling seamless knowledge transfer between patient care and research. The platform's architecture and standardized terminologies significantly improved data quality and facilitated robust querying. Challenges notwithstanding, the platform demonstrated reliability in handling diverse data types, integration effectiveness, and scalability, validating our hypotheses. Ongoing development and potential quantitative measures will further enhance its applicability and performance in dynamic health care landscapes.
Values Clarity, Action, and Posttraumatic Growth Arising from the COVID-19 Pandemic
Authors: Comeau Thea Lauree , Marjanovic Zdravko , Dhanoa Tarleen 
Published: March 2024

Abstract

In the midst of the COVID-19 pandemic’s peak, many individuals faced unprecedented levels of perceived threat. That being said, it has been reported that many individuals also reported positive psychological outcomes and engagement in altruistic or prosocial behaviour. This quasi-experimental study delves into the interplay of sample types (students versus community members) and sample timing (pre- and post-vaccine availability) on psychological disruption variables tied to positive psychological outcomes. Through a comprehensive questionnaire comprising seven measures, administered online to participants from distinct populations at two crucial time points, our findings unravel a compelling narrative. Notably, the community and Time 1 sample consistently exhibit heightened levels of psychological disruption, posttraumatic growth, and positive psychological outcomes. As anticipated, mediation analysis underscores the pivotal role of a disruption in core beliefs in mediating the relationship between threatening events and posttraumatic growth. This study not only sheds light on these intricate dynamics but also holds implications for researchers navigating the multifaceted landscape of psychological outcomes in the face of unprecedented global challenges.
On the (in)Efficiency of Fuzzing Network Protocols
Authors: Andarzian Seyed Behnam , Daniele Cristian , Poll Erik 
Published: March 2024

Abstract
Fuzzing is a great technique to find software bugs. However, certain types of systems, notably network protocols, are still challenging to fuzz because of in-efficiency. As an extended version of our previous article, we identify the root causes for overhead in fuzzing network protocols. After that, we categorize and discuss strategies for fuzzing network protocols. As a result, this article presents a comprehensive analysis of all the root causes behind the inefficiency of fuzzing network protocols and all the strategies to avoid them.
Laparoscopic approach to Acute Abdomen: A Multicenter Study
Authors: Eljack Abdelmoneim Mohammed Ali , Adam YousifAbdallah , Elhafiz Mohamed 
Published: March 2024

Abstract
Background
Laparoscopy has become a routine procedure for managing acute abdominal disease and can be considered an excellent therapeutic and additional diagnostic tool in select patients.
Objective
To determine the diagnostic and therapeutic value of laparoscopy for managing acute abdomen in Khartoum.
Methods
This was a prospective, descriptive, cross–sectional hospital-based study. The study was conducted in six centres around Khartoum State from October 2017 to October 2018. Patients whose laparoscopy was used for either diagnostic or therapeutic purposes for acute abdomen were selected.
Results
The mean age was 29 ± 2.3 years. The duration of symptoms in 42(70%) of the patients was 24–48 hours. The three common clinical diagnoses were acute cholecystitis in 18 patients (30%), acute appendicitis in 13 patients (21.7%), and uncertain diagnosis in 11 patients (18.3%). The most common operative findings were the pathology of the appendix 14 (23.3%) and the gallbladder 14 (23.3%). The sensitivity, specificity, and accuracy of laparoscopy for acute abdomen were 93.5%, 42.9%, and 81.8%, respectively. The results indicated good sensitivity, specificity, and high accuracy. The only reported immediate complication of the laparoscopic approach was bleeding in one patient. Unnecessary laparotomy was avoided in 10 patients (16.6%), 3 had lap adhesiolysis, 4 had perforated duodenal ulcers, 3 had sealed ulcers, and 1 had a graham patch. Another patient underwent foreign body (pin) removal after trauma with a pin gun, 1 had an ectopic pregnancy, and one had a cholecystostomy tube.
A diagnosis was confirmed in 11 (18.3%) patients who were classified as uncertain preoperatively.
The reported late complications were port site infection in 4 patients (6.7%) and incisional hernia in 1 patient (1.7%). The duration of surgery was less than 2 hours in 38 patients (63.3%). 47(78.3%) of the patients started oral feeding within 24 hours. The length of hospital stay was 1-2 days for 48 (80%) of the patients.
Conclusion
Emergency laparoscopy for acute abdomen surgery is safe and accurate; these techniques reduce the rate of unnecessary laparotomy and avoid delays in diagnosis.
Early Cardio-Oncology Intervention in Thoracic Radiotherapy: Results of the Cardiac Aggressive Risk Mitigation (CARMA) Pilot Study
Authors: Atkins Katelyn , Zhang Samuel , Gasho Jordan , Eno Celeste , Silos Katrina , Pendergast Felicity , Zhang Wenjuan , Vail Eric , Kamrava Mitchell , Hakimian Behrooz , Mirhadi Amin , Mak Raymond , Nikolova Andriana 
Published: March 2024

Abstract

Background
While there is increasing recognition of the morbidity of cardiovascular disease (CVD) in cancer survivors, including accelerated atherosclerosis following thoracic radiotherapy (RT), patients are frequently under-optimized for CV risk.
Methods
In this prospective single-arm pilot study, patients were treated with high-dose thoracic RT and had early consultation with cardio-oncology. The primary endpoint was adherence to cardio-oncology consultation. Secondary endpoints were cardio-oncology CV medication intervention rate and patient-reported intervention perspectives.
Results
Twenty patients were enrolled. The median age was 71 years. Most were female (13/20), had primary lung/mediastinal carcinoma (12/20), and 7/20 had pre-existing atherosclerotic CVD. Cardio-oncology consultation was completed in 19/20 patients and resulted in CV medication optimization changes in 12/19, most commonly to initiate/increase statin therapy. 8/12 patients with a primary cardiologist prior to enrollment had medication changes recommended. Most (12/17) were glad to learn about their heart health during cancer treatment.
Conclusions
To our best knowledge, this is the first study reporting adherence and outcomes of early cardio-oncology intervention and patient reported perspectives. We observed in this high CV risk cohort that early cardio-oncology consultation was feasible, led to CV medication optimization in majority (> 60%) of participants, was viewed positively by patients, and worthy of further study.
Mindset dynamics in clinical learning environments: Unravelling the Goldilocks paradox
Authors: Hopkins Samantha Rae , Rae Valerie Isobel , Smith Samantha E. , Tallentire Victoria R. 
Published: March 2024

Abstract

Background
Doctors in training (trainees) have higher rates of burnout, anxiety and depression than other professionals. An important psychological tool to combat this crisis is promotion of a growth mindset, which increases resilience and improves mental health outcomes. How growth mindset might be promoted within the clinical learning environment is underexplored. This study aimed to explore the factors promoting a growth mindset versus fixed mindset in trainees.
Methods
This constructivist study employed a novel method of encouraging reflections on mindset adoption in the clinical learning environment. Trainees played Mindset, a tabletop simulation board game that included challenges encountered within training. This was followed by a facilitated debriefing, focusing on factors that promoted growth or fixed mindset adoption in the clinical learning environment. Debriefing transcripts were analysed using template analysis.
Results
Three groups of oncology trainees and one group of medical education fellows participated (16 participants in total). Factors promoting growth mindset adoption included passion, collaboration, diverse career and role modelling. Factors promoting fixed mindset adoption included burnout and competition. Some factors, such as grit, previous success experience and singular training location promoted a fixed mindset when too much or too little were present, and promoted a growth mindset when they were in balance (the Goldilocks paradox).
Conclusions
The importance of balance versus excess of certain factors, and the ubiquitous competitive culture in medicine promoting a fixed mindset, were compelling reflections. This study may aid invested parties to reflect on what factors they can upregulate and down regulate to optimise trainees’ adoption of a growth mindset.
Treatment and Prognosis for Pancreatic Duct Disruption Associated with Pancreatic Cancer: a case series of 16 patients
Authors: Oka Yuki , Tanaka Takeshi , Kobayashi Takashi , Masuda Atsuhiro , Sakai Arata , Tsujimae Masahiro , Abe Shohei , Gonda Masanori , Masuda Shigeto , Uemura Hisahiro , Kohashi Shinya , Inomata Noriko , Nagao Kae , Harada Yoshiyuki , Miki Mika , Irie Yosuke , Juri Noriko , Ko Testuhisa , Yokotani Yusuke , Toyama Hirochika , Fukumoto Takumi , Kodama Yuzo 
Published: March 2024

Abstract
Pancreatic duct (PD) disruption can be attributed to pancreatic cancer. This study investigated the therapeutic modalities and prognostic implications of PD disruption in pancreatic cancer. This retrospective study included 16 patients with PD disruption concomitant with pancreatic cancer between April 2011 and March 2023. Of the 16 cases of PD disruption, 12, nine, and two included pseudocysts, infected cysts, and walled–off necrosis, respectively. Five patients underwent endoscopic pancreatic stenting, nine were managed endoscopic ultrasonography-guided pancreatic fluid collection drainage, and two were treated with lumen-apposing metal stent placement. All patients achieved both technical and clinical success without complications. The clinical stage of pancreatic cancer spanned from carcinoma in situ to the metastatic phase. For the treatment of pancreatic cancer, six patients underwent surgical resection, and eight underwent chemotherapy. No cases of peritoneal dissemination were observed. The median overall survival from the diagnosis of pancreatic cancer in the resected and non-resected cases was 2222 and 289 days, respectively. Endoscopic intervention was effective in all cases of PD disruption due to pancreatic cancer. Furthermore, even in cases of pancreatic cancer after PD disruption, survival rates were similar to those in cases without PD disruption and were achieved through surgical resection or chemotherapy.
Causal Relationship between Autoimmune Diseases and Risk of Osteonecrosis in European Population: A Two-Sample Mendelian Randomization Study
Authors: Lian Zheng , Zhang Fang , Wang Yongbin , Bai Wenzhe , Zhu Kai , Ma Xuexiao 
Published: March 2024

Abstract

Background: Prior epidemiological and observational studies have identified a series of autoimmune diseases (ADs) linked with osteonecrosis (ON), although potential confounding variables have not been fully accounted for. Furthermore, comprehensive studies elucidating the causal relationship between autoimmune diseases and osteonecrosis are lacking. Objective: This research endeavored to clarify the causal relationship between a myriad of autoimmune diseases and ON through the application of a Mendelian randomization (MR) methodology.
Methods: To explore the causal relationship between ADs and ON, Single Nucleotide Polymorphism (SNP) loci, firmly correlated with 12 autoimmune diseases including, but not limited to, type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE), as well as osteonecrosis, were chosen as instrumental variables (IV). These were sourced from both the Finnish database (Finn-Gen) and the Genome-Wide Association Study (GWAS) public database. Various evaluation methods, such as inverse variance weighted (IVW), Simple Mode, MR-Egger, and weighted median and model, were employed to assess the causal relationship between 12 ADs and ON. Inverse variance weighted (IVW) is a widely utilized statistical method in genetic association studies for estimating and integrating genetic effects. It is particularly relevant for estimating single genetic effects across multiple genetic variant loci. Owing to its robust causal inference capabilities, IVW was employed as the primary analytical method in this MR study. For sensitivity analysis, MR-PRESSO, inverse variance weighted, MR-Egger, and a battery of other methods were utilized.
Results: Post-MR analysis, IVW findings indicated that T1DM (OR=1.062; P=0.007), RA (OR=1.248; P=7.19×10-5), and AS (OR=8.50×1010; P=0.034) served as risk factors for osteonecrosis. Meanwhile, other autoimmune diseases such as myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), and psoriatic arthritis (PsA) did not exhibit a causal link with osteonecrosis. Additionally, the results of the reverse MR analysis failed to reveal any significant causal relationship between ON and ADs.
Conclusion: This research substantiated that T1DM, AS, and RA are prominent risk factors for osteonecrosis in European Population, utilizing a two-sample MR approach for both directions.
OptoRibo-seq for spatiotemporally resolved mapping of local protein translatome
Authors: Zou Peng , Wang Ruixuan , Wang Ruixiang , Wang Wentao , Liu Yanjun , Zheng Fu , Luo Huixin , Chen Peng 
Published: March 2024

Abstract

Localized protein translation occurs in numerous subcellular compartments and regulates diverse biological processes by rapidly changing protein compositions in response to subcellular needs. Existing assays for subcellular local translation either require physical isolation, which is prone to contamination and loss of material, or imaging-based readout, which is often hampered with low throughput. In this study, we report the development of optoRibo-seq method that features photoactivatable enzyme-mediated proximity labeling of ribosomes in genetically specified subcellular locations. We demonstrate the spatial specificity of optoRibo-seq at the endoplasmic reticulum (ER) membrane and mitochondrial outer membrane. OptoRibo-seq is further applied to map the dynamic changes in the ER-proximal translatome in cells undergoing chemically induced ER stress, identifying transcripts involved in protein folding and amino acid transport. Our strategy provides a general platform for spatiotemporally resolved profiling of subcellular protein translation in various organelles.