bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study on Torsional Friction of Stringing Blocks on Conductor in Tension Stringing Construction
Authors: Qin Jian , Qiao Liang , Qi Zhiqiang , Zhang Xuekai , Wang Shunling 
Published: March 2024

Abstract
An experimental study was conducted to analyze the torsional friction effect of stringing blocks on the conductor during tension stringing construction. By analyzing the torsional friction force of stringing blocks on the conductor, the torsional friction experimental device of the stringing blocks on the conductor was designed. The torsional friction torque of the JL/G1A-630/45-45/7 Aluminum Conductor Steel Reinforced (ACSR) under the different tensions and wrap angles passing through the stringing blocks was measured, and then the friction coefficient was obtained. The experimental results show that the torsional friction coefficient of the stringing blocks to the conductor μ decreases with the increase of the tension of the conductor and the wrap angle passing through the stringing blocks. The relationship between the coefficient of friction and the wrap angle and tension of the conductor passing through the stringing blocks is obtained by fitting, and the formula for calculating the torsional frictional torque is obtained.
Preparation of celecoxib loaded bioactive glass chitosan composite hydrogels: a simple approach for therapeutic delivery of NSAIDs
Authors: Jalal Azra , Ahmad Sana , Shah Asma Tufail , Hussain Tousif , Nawaz Hafiz Awais , Imran Saleha 
Published: March 2024

Abstract
Arthritis causes inflammatory damage to joints and connective tissues. In the treatment of arthritis, precise and controlled drug delivery to the target site is among the frontline research approaches. In the present research work, celecoxib drug and bioactive glass incorporated chitosan hydrogels were fabricated by the freeze gelation method. Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis/differential scanning calorimetry techniques were used to characterize the hydrogels. Different kinetic models were applied to study the drug release kinetics. The celecoxib release was mainly controlled by a Fickian diffusion process followed by the Higuchi model. Maximum 86.2% drug entrapment was observed in 20 mg drug-loaded hydrogel and its swelling ratio was 115.5% in 28 d. Good hydrophilicity, good drug entrapment efficiency, and moderate drug release patterns of hydrogels can make them suitable for sustained drug release. The cytocompatibility of hydrogels was established by performing an MTT assay on the BHK-21 fibroblast cell line. The promising results have proved that hydrogels can be considered potential material for the slow release of anti-inflammatory drug at the target site in arthritis.
Demand-side climate change mitigation: where do we stand and where do we go?
Authors: Creutzig Felix , Roy Joyashree , Minx Jan 
Published: March 2024

Abstract
It is now well established that the demand side can contribute substantially to climate change mitigation thus increasing the solution space. The recent IPCC synthesis report for the first time explicitly reflected this class of solutions. Here, we provide an overview of an unique set of 22 review papers published in the focus issue of Environmental Research Letters. We also extract a key set of insights, ranging from the varied but rapidly evolving literature to demand-side mitigation potential, relevance for well-being, and consistent categorization of options across end-use sectors. We find that demand-side approaches to climate change mitigation supplement exclusively technology-focused supply side solutions and, in many cases, comprise system-wide effect contributing to well-being and planetary stability. Review studies cover macro-economics, well-being, and sustainable development goals on the metric side, and investigate consumption-based individual options, urban strategies, transport, building, and food sector potentials, but also the role of the circular economy, material efficiency, and digitalization. Demand-side measures can be categorized into avoid, shift, and improve approaches. Several additional reviews systematically investigate psychological and social approaches and initiatives to foster climate change mitigation. We finally outline important gaps and questions to be tackled in the coming years.
ReHoGCNES-MDA: prediction of miRNA-disease associations using homogenous graph convolutional networks based on regular graph with random edge sampler
Authors: Zhang Yufang , Chu Yanyi , Lin Shenggeng , Xiong Yi , Wei Dong-Qing 
Published: March 2024

AbstractNumerous investigations increasingly indicate the significance of microRNA (miRNA) in human diseases. Hence, unearthing associations between miRNA and diseases can contribute to precise diagnosis and efficacious remediation of medical conditions. The detection of miRNA-disease linkages via computational techniques utilizing biological information has emerged as a cost-effective and highly efficient approach. Here, we introduced a computational framework named ReHoGCNES, designed for prospective miRNA-disease association prediction (ReHoGCNES-MDA). This method constructs homogenous graph convolutional network with regular graph structure (ReHoGCN) encompassing disease similarity network, miRNA similarity network and known MDA network and then was tested on four experimental tasks. A random edge sampler strategy was utilized to expedite processes and diminish training complexity. Experimental results demonstrate that the proposed ReHoGCNES-MDA method outperforms both homogenous graph convolutional network and heterogeneous graph convolutional network with non-regular graph structure in all four tasks, which implicitly reveals steadily degree distribution of a graph does play an important role in enhancement of model performance. Besides, ReHoGCNES-MDA is superior to several machine learning algorithms and state-of-the-art methods on the MDA prediction. Furthermore, three case studies were conducted to further demonstrate the predictive ability of ReHoGCNES. Consequently, 93.3% (breast neoplasms), 90% (prostate neoplasms) and 93.3% (prostate neoplasms) of the top 30 forecasted miRNAs were validated by public databases. Hence, ReHoGCNES-MDA might serve as a dependable and beneficial model for predicting possible MDAs.
Auditory aversive generalization learning prompts threat-specific changes in alpha-band activity
Authors: Farkas Andrew H , Ward Richard T , Gilbert Faith E , Pouliot Jourdan , Chiasson Payton , McIlvanie Skylar , Traiser Caitlin , Riels Kierstin , Mears Ryan , Keil Andreas 
Published: March 2024

Abstract
Pairing a neutral stimulus with aversive outcomes prompts neurophysiological and autonomic changes in response to the conditioned stimulus (CS+), compared to cues that signal safety (CS−). One of these changes—selective amplitude reduction of parietal alpha-band oscillations—has been reliably linked to processing of visual CS+. It is, however, unclear to what extent auditory conditioned cues prompt similar changes, how these changes evolve as learning progresses, and how alpha reduction in the auditory domain generalizes to similar stimuli. To address these questions, 55 participants listened to three sine wave tones, with either the highest or lowest pitch (CS+) being associated with a noxious white noise burst. A threat-specific (CS+) reduction in occipital–parietal alpha-band power was observed similar to changes expected for visual stimuli. No evidence for aversive generalization to the tone most similar to the CS+ was observed in terms of alpha-band power changes, aversiveness ratings, or pupil dilation. By-trial analyses found that selective alpha-band changes continued to increase as aversive conditioning continued, beyond when participants reported awareness of the contingencies. The results support a theoretical model in which selective alpha power represents a cross-modal index of continuous aversive learning, accompanied by sustained sensory discrimination of conditioned threat from safety cues.
Distinct and common mechanisms of cross-model semantic conflict and response conflict in an auditory relevant task
Authors: Xu Honghui , Yang Guochun , Göschl Florian , Nolte Guido , Ren Qiaoyue , Li Zhenghan , Wu Haiyan , Engel Andreas K , Li Qi , Liu Xun 
Published: March 2024

AbstractThe mechanisms of semantic conflict and response conflict in the Stroop task have mainly been investigated in the visual modality. However, the understanding of these mechanisms in cross-modal modalities remains limited. In this electroencephalography (EEG) study, an audiovisual 2–1 mapping Stroop task was utilized to investigate whether distinct and/or common neural mechanisms underlie cross-modal semantic conflict and response conflict. The response time data showed significant effects on both cross-modal semantic and response conflicts. Interestingly, the magnitude of semantic conflict was found to be smaller in the fast response time bins than in the slow response time bins, whereas no such difference was observed for response conflict. The EEG data demonstrated that cross-modal semantic conflict specifically increased the N450 amplitude. However, cross-modal response conflict specifically enhanced theta band power and theta phase synchronization between the medial frontal cortex (MFC) and lateral prefrontal electrodes as well as between the MFC and motor electrodes. In addition, both cross-modal semantic conflict and response conflict led to a decrease in P3 amplitude. Taken together, these findings provide cross-modal evidence for domain-specific mechanism in conflict detection and suggest both domain-specific and domain-general mechanisms exist in conflict resolution.
Quantification of mediation effects of white matter functional characteristics on cognitive decline in aging
Authors: Li Muwei , Schilling Kurt G , Gao Fei , Xu Lyuan , Choi Soyoung , Gao Yurui , Zu Zhongliang , Anderson Adam W , Ding Zhaohua , Landman Bennett A , Gore John C 
Published: March 2024

Abstract
Cognitive decline with aging involves multifactorial processes, including changes in brain structure and function. This study focuses on the role of white matter functional characteristics, as reflected in blood oxygenation level-dependent signals, in age-related cognitive deterioration. Building on previous research confirming the reproducibility and age-dependence of blood oxygenation level-dependent signals acquired via functional magnetic resonance imaging, we here employ mediation analysis to test if aging affects cognition through white matter blood oxygenation level-dependent signal changes, impacting various cognitive domains and specific white matter regions. We used independent component analysis of resting-state blood oxygenation level-dependent signals to segment white matter into coherent hubs, offering a data-driven view of white matter’s functional architecture. Through correlation analysis, we constructed a graph network and derived metrics to quantitatively assess regional functional properties based on resting-state blood oxygenation level-dependent fluctuations. Our analysis identified significant mediators in the age-cognition relationship, indicating that aging differentially influences cognitive functions by altering the functional characteristics of distinct white matter regions. These findings enhance our understanding of the neurobiological basis of cognitive aging, highlighting the critical role of white matter in maintaining cognitive integrity and proposing new approaches to assess interventions targeting cognitive decline in older populations.
Bacterial diversity in a continuum from supraglacial habitats to a proglacial lake on the Tibetan Plateau
Authors: Xing Tingting , Liu Keshao , Ji Mukan , Chen Yuying , Liu Yongqin 
Published: March 2024

Abstract
Mountain glaciers are frequently assessed for their hydrological connectivity from glaciers to proglacial lakes. Ecological process on glacier surfaces and downstream ecosystems have often been investigated separately, but few studies have focused on the connectivity between the different glacial habitats. Therefore, it remains a limited understanding of bacterial community assembly across different habitats along the glacier hydrological continuum. In this study, we sampled along a glacial catchment from supraglacial snow, cryoconite holes, supraglacial runoff, ice-marginal moraine and proglacial lake on the Tibetan Plateau. The bacterial communities in these habitats were analyzed using high-throughput DNA sequencing of the 16S rRNA gene to determine the bacterial composition and assembly. Our results showed that each habitat hosted unique bacterial communities, with higher bacterial α-diversity in transitional habitats (e.g. runoff and ice-marginal moraine). Null model analysis indicated that deterministic processes predominantly shaped bacterial assembly in snow, cryoconite holes and lake, while stochastic process dominantly governed bacterial community in transitional habitats. Collectively, our findings suggest that local environment play a critical role in filtering bacterial community composition within glacier habitats. This study enhances our understanding of microbial assembly process in glacier environments and provides valuable insights into the factors governing bacterial community compositions across different habitats along the glacial hydrological continuum.
Evolution and genetics of accessory gland transcriptome divergence between Drosophila melanogaster and D. simulans
Authors: Majane Alex C , Cridland Julie M , Blair Logan K , Begun David J 
Published: March 2024

Abstract
Studies of allele-specific expression in interspecific hybrids have provided important insights into gene-regulatory divergence and hybrid incompatibilities. Many such investigations in Drosophila have used transcriptome data from complex mixtures of many tissues or from gonads, however, regulatory divergence may vary widely among species, sexes, and tissues. Thus, we lack sufficiently broad sampling to be confident about the general biological principles of regulatory divergence. Here, we seek to fill some of these gaps in the literature by characterizing regulatory evolution and hybrid misexpression in a somatic male sex organ, the accessory gland, in F1 hybrids between Drosophila melanogaster and D. simulans. The accessory gland produces seminal fluid proteins, which play an important role in male and female fertility and may be subject to adaptive divergence due to male–male or male–female interactions. We find that trans differences are relatively more abundant than cis, in contrast to most of the interspecific hybrid literature, though large effect-size trans differences are rare. Seminal fluid protein genes have significantly elevated levels of expression divergence and tend to be regulated through both cis and trans divergence. We find limited misexpression (over- or underexpression relative to both parents) in this organ compared to most other Drosophila studies. As in previous studies, male-biased genes are overrepresented among misexpressed genes and are much more likely to be underexpressed. ATAC-Seq data show that chromatin accessibility is correlated with expression differences among species and hybrid allele-specific expression. This work identifies unique regulatory evolution and hybrid misexpression properties of the accessory gland and suggests the importance of tissue-specific allele-specific expression studies.
Reconceptualizing the Nation in Sanctuary Practices: Toward a Progressive, Relational National Politics?
Authors: Wyn Edwards Catrin , Dafydd Jones Rhys 
Published: March 2024

Abstract
This article explores sanctuary in Wales, focusing on the Welsh Government’s recent declaration to become a Nation of Sanctuary (NoS), and identifying how the national scale provides an alternative locus for progressive sanctuary measures. In revealing the nation’s emergence as another crucial site of sanctuary, the work reconceptualizes the nation’s place in sanctuary policies and practices in two ways: (i) it locates sanctuary through a national scale, thus moving beyond the city/state dichotomy that has dominated explanations of sanctuary, and (ii) it shows the importance of decoupling the nation-state compound while simultaneously integrating the nation(al) into discussions on sanctuary without being bound to the state or xenophobic populism. In showing how “nations against the state” can participate in sanctuary measures, we expand the current understanding of where sanctuary can be found, and capture the various forms of national belonging and identities that exist within plurinational states, including alternative, progressive forms of civic belonging. This is particularly significant in light of the tightening of state immigration policies, greater regulation of immigrant entry at state borders, and continuation of restrictive citizenship policies witnessed in recent years, which have ignited sanctuary measures aimed at creating safe spaces beyond the reach of state measures.
Blockchain as a database—proposal for a new test for the criterion of ‘independence’ in the legal definition of a database for the purposes of copyright and the sui generis right
Authors:  Ari Ilsu Erdem 
Published: March 2024

Abstract
Technology’s exponential growth often outpaces that of the law. The persistence of outdated legal concepts that were not drafted with new technology in mind leads to legal uncertainty. This article focuses on one example of such a friction between old law and new technology, namely the eligibility of blockchain as a‘database’ for protection under the EU Database Directive, as implemented into UK copyright law. The most problematic requirement for blockchain as a candidate is that the material inside the database be ‘independent’. This can pose a significant hurdle for blockchain to succeed as the immutability of blockchain is ensured by the ‘linked-list’ structure in between the blocks and the combinational hashing of data within the individual block. This article examines this issue and proposes a solution to this quandary: to divide the data recorded on a blockchain into ‘content’ and ‘structure’, and confine the criterion of ‘independence’ to the former. In reaching this solution, the author examines previous literature on the different types of data that can be found in databases, as well as how the concept of ‘independence’ is understood by judges and academics. This article will be of practical significance for developers of non-open source blockchain applications who wish to protect their products as a database.
Mechanism of oxalate decarboxylase Oxd_S12 from Bacillus velezensis BvZ45-1 in defence against cotton verticillium wilt
Authors: Sun Ying , Yang Na , Li Sirui , Chen Fei , Xie Yijing , Tang Canming 
Published: March 2024

Abstract
Verticillium wilt, a soilborne vascular disease caused by Verticillium dahliae, strongly affects cotton yield and quality. In this study, an isolated rhizosphere bacterium, designated Bacillus velezensis BvZ45-1, exhibited &gt;46% biocontrol efficacy against cotton verticillium wilt under greenhouse and field conditions. Moreover, through crude protein extraction and mass spectrometry analyses, we found many antifungal compounds present in the crude protein extract of BvZ45-1. The purified oxalate decarboxylase Odx_S12 from BvZ45-1 inhibited the growth of V. dahliae Vd080 by reducing the spore yield, causing mycelia to rupture, spore morphology changes, cell membrane rupture, and cell death. Subsequently, overexpression of Odx_S12 in Arabidopsis significantly improved plant resistance to V. dahliae. Through studies of the resistance mechanism of Odx_S12, V. dahliae was shown to produce oxalic acid (OA), which has a toxic effect on Arabidopsis leaves. Odx_S12 overexpression reduced Arabidopsis OA content, enhanced tolerance to OA, and improved resistance to verticillium wilt. Transcriptomics and quantitative real-time PCR analysis revealed that Odx_S12 promoted a reactive oxygen species burst and a salicylic acid- and abscisic acid-mediated defence response in Arabidopsis. In summary, this study not only identified B. velezensis BvZ45-1 as an efficient biological control agent, but also identified the resistance gene Odx_S12 as a candidate for cotton breeding against verticillium wilt.
Imaging and spectroscopic observations of a confined solar filament eruption with two-stage evolution
Authors: Xu Zhe , Yan Xiaoli , Yang Liheng , Xue Zhike , Wang Jincheng , Zhou Yian 
Published: March 2024

ABSTRACT
Solar filament eruptions are often characterized by stepwise evolution due to the involvement of multiple mechanisms, such as magnetohydrodynamic instabilities and magnetic reconnection. In this article, we investigated a confined filament eruption with a distinct two-stage evolution by using the imaging and spectroscopic observations from the Interface Region Imaging Spectrograph and the Solar Dynamics Observatory. The eruption originated from a kinked filament thread that separated from an active region filament. In the first stage, the filament thread rose slowly and was obstructed due to flux pile-up in its front. This obstruction brought the filament thread into reconnection with a nearby loop-like structure, which enlarged the flux rope and changed its connectivity through the foot-point migration. The newly formed flux rope became more kink unstable and drove the rapid eruption in the second stage. It ascended into the upper atmosphere and initiated the reconnection with the overlying field. Finally, the flux rope was totally disintegrated, producing several solar jets along the overlying field. These observations demonstrate that the external reconnection between the flux rope and overlying field can destroy the flux rope, thus playing a crucial role in confining the solar eruptions.
The bicoherence study of quasi-periodic oscillations in MAXI J1535−571
Authors: Zhu Ziyuan , Chen Xiao , Wang Wei 
Published: March 2024

ABSTRACT
Bicoherence is a way to measure the phase coupling of triplets of Fourier frequencies. We use this method to analyse quasi-periodic oscillations (QPOs) in the black hole X-ray binary MAXI J1535−571 during its 2017 September–October outburst. The bicoherence provides an interesting new diagnostic to uncover QPO behaviour and the relationships between QPO harmonics and broad-band noise. The bicoherence pattern of type-C QPOs starts as a ‘web’ pattern and changes to a ‘hypotenuse’ pattern after the presence of type-B QPOs, indicating that MAXI J1535−571 is a low-inclination source. The intensity of bicoherence also exhibits variations across different energy bands. We try to explain the bicoherence results in the scenario of a dual-corona geometry.