bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early hilar lung cancer: Its clinical aspect
Authors: Watanabe Yoh , Shimizu Junzo , Oda Makoto , Iwa Takashi , Takashima Tsutomu , Kamimura Ryoichi , Kitagawa Masanobu , Nonomura Akitaka , Nakamura Shinobu , Tanimoto Kazuo , Matsubara Fujitsugu , Ikegaki Shigeru , Yamada Katuji 
Published: February 2007

AbstractEarly hilar lung cancers are rare, but are curable if they are properly diagnosed and treated. In the past 14 years, we have treated 27 patients with early hilar cancers that fulfilled the criteria proposed by the Japanese Lung Cancer Society (JLCS). Eighteen patients presented with symptoms and 9 were detected by the mass screening examination of sputum cytology. All lesions in both groups were finally diagnosed by bronchoscopy. Twenty patients (74%) had positive sputum cytology, whereas only 7 (26%) had positive chest X‐ray findings. All the patients underwent surgery, and bronchoplasty was the most frequent operative procedure. The 5‐year survival rate was 100%, and the 10‐year survival rate was 91.7%, as one patient died of a second primary lung cancer in the 6th postoperative year. In conclusion, the definition of early hilar lung cancer proposed by the JLCS is thought to be reasonable, and early hilar lung cancer is a curable disease, if it is properly diagnosed and treated.
Metastases to the breast: Differential diagnosis from primary breast carcinoma
Authors: Vergier Beatrice , Trojani Monique , De Mascarel Isabelle , Coindre Jean‐Michel , Le Treut Alain 
Published: February 2007

AbstractEight patients with breast metastases from primary tumors other than breast carcinoma were studied: 3 malignant melanomas, 2 rhabdomyo‐sarcomas, 1 malignant mesothelioma, 1 appendiceal carcinoid, and 1 epidermoid cervical carcinoma. All had mammographic, histopathologic, and immunohistochemical examinations. The main problem was differential diagnosis from primary breast carcinoma. History of extramammary primary tumor was helpful but breast metastasis was the first clinical feature in 2 cases. Patients had noticed palpable, round, rapid growth masses which were mammographically benign. Pathologic diagnosis was difficult and immunohistochemical studies necessary, whenever the proliferation had histologic features of primary breast carcinoma or when no primary tumor was known. However, some histologic features were of value for diagnosis of metastasis: atypical histologic features for a primary breast carcinoma, a well‐circumscribed tumor with multiple satellite foci, the absence of an intraductal component, and the presence of many lymphatic emboli. In adults, the most frequent types of tumors metasta‐sizing in the breast are malignant melanoma and neuroendocrine‐like tumors, especially small cell carcinoma and carcinoid. In children, rhabdomyosarcoma is the most common. Accurate diagnosis of breast metastasis is important to avoid unnecessary mastectomy and to implement an appropriate systemic therapy.
Gastric carcinoma metastatic to the breast
Authors: Hamby Leigh S. , McGrath Patrick C. , Cibull Michael L. , Schwartz Richard W. 
Published: February 2007

AbstractA patient with signet ring adenocarcinoma of the stomach with metastatic disease to the breast treated at our institution is presented and added to the 14 cases reported in the literature. A review of the common clinical features and possible mechanisms of metastases is given. While the majority of patients present with symptoms referable to their gastric malignancy, the patient in this case initially sought treatment because of her breast mass. Metastatic deposits within the breast may be difficult to distinguish from primary breast carcinoma. For this reason, immunohistochemistry utilizing carcinoembryonic antigen (CEA), C‐ERB B‐2, and gross cystic protein were used in this case to confirm an extramammary source. In order to prevent unnecessary breast surgery and provide proper treatment of the gastric primary, the patient's complete clinical presentation must be used to guide diagnostic evaluation.
Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report
Authors: Grinis Gedas , Targonski Paul , Shaw Michael , Rubenstein Marvin , Guinan Patrick D. 
Published: February 2007

AbstractIn an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions (P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.
A phase II pilot study of the combined application of hyperthermia and intra‐hepato‐arterial chemotherapy using cisplatinum and 5‐fluorouracil
Authors: Hamazoe Ryuichi , Murakami Atsunobu , Hirooka Yasuaki , Maeta Michio , Kaibara Nobuaki 
Published: February 2007

AbstractFourteen patients (group A) with unresectable metastasis to the liver from colorectal cancers (11 patients) and gastric cancers (3 patients) were treated with the combined application of hyperthermia and intra‐hepatoarterial (IHA) chemotherapy with cisplatinum and 5‐fluorouracil. Ten patients were treated with regional hyperthermia applied with a radiofrequency capacitive heating system and four patients were treated with total‐body hyperthermia concurrently with IHA chemotherapy. Thirty‐one patients (group B) with liver metastases from colorectal and gastric cancers received only IHA chemotherapy with the same chemotherapeutic regimen. In group B, partial responses (PRs) were obtained in 8 of 17 evaluable patients with colorectal cancer and in 1 of 10 evaluable patients with gastric cancer. In group A, PRs were found in 6 of 11 patients with colorectal cancer and in 2 of 3 patients with gastric cancer. Furthermore, improvements due to the combination of chemotherapy with hyperthermia were noted in 3 of 6 patients with colorectal cancer who had received unsuccessful prior IHA chemotherapy. The 50% survival period was prolonged to 23 months in group A from 11 months in group B, for patients with colorectal cancer. Toxicity of IHA chemotherapy was not potentiated by combination with hyperthermia. These results indicate that the combination of hyperthermia with IHA chemotherapy has a therapeutic benefit in the treatment of unresectable metastatic liver tumors derived from colorectal and gastric cancers.
Congenital mesoblastic nephroma, nephrocalcinosis, and hypertrophic pyloric stenosis
Authors: Angulo Javier C. , Lopez Jose I. , Ereñao Cosme , Flores Nicolas 
Published: February 2007

AbstractA cellular variant of congenital mesoblastic nephroma (CMN) occurring in a newborn is presented. Coincidental findings were congenital hypertrophic pyloric stenosis (CHPS) and nephrocalcinotic hypercalcemia that reverted after nephrectomy. As of the day of writing, this multiple association has not been reported. The authors believe that both CMN and CHPS could be interpreted as fibroblastic proliferative‐related entities. Transient hypercalcemia seems to be a paraneoplastic phenomenon.
Subtotal submucosal cricoid resection: An experimental study
Authors: Shaha Ashok , Burnett Carlos , Dimaio Terry , Jaffe Bernard M. 
Published: February 2007

AbstractIt has generally been considered that the cricoid cartilage is essential for maintaining airway continuity. The purpose of this experimental study was to test this concept by evaluating the effects of subtotal excision of the canine cricoid cartilage. Eight adult mongrel dogs were studied. They received general anesthesia and were intubated. By using a vertical midline incision, the cricoid cartilage was exposed. Subtotal cricoid resection was performed by submucosal dissection; the mucosal continuity was not violated. The resultant defect in the cricoid cartilage was reconstructed with a polytetrafluoroethylene (PTFE) graft which was sutured in place with prolene sutures. All the dogs were extubated immediately after surgery. None required tracheostomy or ventilatory support and none had any respiratory problems during the follow‐up period. They were all able to eat soon after surgery.The animals were followed for up to 4 to 6 months and then sacrificed to permit evaluation of the condition of the airway and subglottic space. There was fibrous scarring outside the graft but no evidence of airway narrowing. Despite submucosal fibrosis, the mucosa appeared normal.The data documented that dogs tolerate subtotal cricoid resection very well and develop no subglottic stenosis. The resultant defect in the cricoid cartilage can readily be reconstructed with a PTFE graft.
Rhabdomyosarcoma of the bladder and prostate in children
Authors: Kamat Muralidhar R. , Kulkarni Jagdeesh N. , Tongaonkar Hemant B. , Ravi R. 
Published: February 2007

AbstractFifteen children, 14 males and 1 female with a mean age of 4.9 years, were treated for rhabdomyosarcoma of the bladder and the prostate, between 1976 and 1985. In 14 patients, the disease was limited to the pelvis, while one had pulmonary metastases. The lesions were trigonal in 12 patients and involved the prostate in the other three. Eleven patients received vincristine‐Adriamycin‐cyclophosphamide (VAC) chemotherapy, followed by radiation therapy. Four of these 11 patients required cystoprostatectomy for residual or persistent disease. Of the remaining four patients, two underwent radical cystoprostatectomy, one partial cystectomy and the patient with pulmonary metastases received only chemotherapy. Six patients were alive at 5 years (40% 5‐year survival). Six patients died of local relapse within 18 months, one patient died of an unknown cause, while two patients were lost to follow‐up free of disease after 2 years.
Receptors for epidermal growth factor and steroid hormones in primary colorectal tumors
Authors: Scambia Giovanni , Panici Pierluigi Benedetti , Bellantone Rocco , Doglietto Giovanni Battista , Sofo Luigi , Ferrandina Gabriella , Ratto Carlo , Bossola Maurizio , Crucitti Francesco , Spagnolo Lucia Cristina , Mancuso Salvatore 
Published: February 2007

AbstractThe presence of epidermal growth factor, estrogen, and progesterone receptors (EGFR, ER, and PR) was investigated by a competitive binding assay in 43 colorectal adenocarcinomas and 32 normal colorectal mucosa specimens. EGFR were expressed in most of the tumor specimens analyzed at levels comparable with normal mucosa. There was no correlation between EGFR and tumor localization, tumor size, tumor stage, and grading. Among tumor specimens, 13.9% and 6.9% expressed very low but detectable ER and PR levels, respectively. No statistically significant difference was found between steroid hormone receptor levels in the tumor and normal mucosa specimens, and neither was there any correlation of ER and PR with the pathological findings. Our results suggest that the EGFR system may play a role in regulating the growth of colorectal tissues. Further studies should demonstrate whether, despite the lack of correlation with histopathological parameters, EGFR expression may have a biological significance in human colorectal cancer.
Esophageal sarcomas
Authors: Perch Steven J. , Soffen Edward M. , Whittington Richard , Brooks John J. 
Published: February 2007

AbstractThe clinical and pathologic characteristics of five patients with esophageal sarcomas are presented, including the only recorded esophageal Triton tumor (malignant schwannoma), the third recorded synovial sarcoma, two patients with carcinosarcoma, and one with leiomyosarcoma. All five patients were males who presented with dysphagia. Three tumors were in the cervical esophagus, and the remaining two were in the distal esophagus. On endoscopic examination, three of the tumors were noted to be polypoid, while the other two were sessile. Two patients presented with disseminated disease, and a third was locally unresectable. These three patients were treated with palliative intent. The remaining two patients underwent surgical excision and postoperative radiation therapy, and are alive and well 6 and 7 years following treatment. This experience suggests that combined modality therapy employing postoperative radiation may be effective in managing these rare lesions.
Treatment of metastatic malignant melanoma with 24 hours continuous venous infusion of dacarbazine and cisplatin
Authors: Icli Fikri , Karaoguz Handan , Dincol Dilek , Gunel Nazan , Demirkazik Ahmet 
Published: February 2007

AbstractTwenty consecutive patients with metastatic malignant melanoma were treated with a combination of 24 hours continuous infusion of dacarbazine (250 mg/m2) and cisplatin (20 mg/m2) for 5 days every 3 weeks. One patient (5%) achieved a complete response (CR) and 3 patients (15%) obtained a partial response (PR) with an overall response rate of 20%. Minimal response was observed in 5 other patients (25%). Complete response duration was 8 months. Median response duration of partial responders was 7 months. Median survival of all responders (CR+PR) was 8.5 months. Toxicity was mild to moderate.
Wilms' tumor in horseshoe kidney: Presentation due to ureteropelvic junction obstruction
Authors: Nirgiotis Jason G. , Black C. Thomas , Sherman Joseph O. 
Published: February 2007

AbstractChildren with horseshoe kidney usually develop urinary tract symptoms and often require operative correction of the anomaly. The incidence of Wilms' tumor in horseshoe kidney is higher than that for the general population. We present the case of a child whose Wilms' tumor was diagnosed early because of ureteropelvic junction obstruction secondary to a horseshoe kidney. A high index of suspicion should be maintained for Wilms' tumor in any child with a horseshoe kidney.
Chemo‐irradiation induced aortoesophageal fistula
Authors: Gabrail Nashat Y. , Harrison Bruce R. , Sunwoo Young C. 
Published: February 2007

AbstractA patient with squamous cell carcinoma of the esophagus developed fatal aortoesophageal (AE) fistula following a preoperative course of combined chemotherapy plus radiation therapy. This is the first reported case of AE fistula following preoperative chemoradiotherapy. This complication is potentially correctable if suspected early, since the massive hemorrhage characteristic of AE fistula is usually preceded by an initial sentinel hemorrhage. The cause of this complication is not clear, but it may be due to inflammation of the vasa vasorum with necrosis of the aortic wall. The concomitant use of fluorouracil and cisplatin with radiation therapy acts as a radiosensitizer and may have potentiated the radiation effect on the aortic wall.
An immunological aspect of melanoma and its potential application in adjuvant therapy
Authors: Elias E. George , Tomazic Vesna J. 
Published: February 2007

AbstractIn an attempt to understand some of the natural immunological characteristics of cutaneous melanoma so that we can plan justifiable immunotherapeutic approaches, 23 patients were studied. The autologous leukocyte migration inhibition assay was utilized to assess in vitro their tumor‐specific cellular immunity. This assay was specifically used because when presensitized lymphocytes are exposed to the same antigen, they release lymphokines which inhibit the natural migration of the leukocytes. All the patients were staged pathologically according to the TNM system. Twelve of them had regional metastasis, i.e., stage III, and underwent regional lymphadenectomy. The other 11 had distant metastases, i.e., stage IV disease, and all their gross tumors were resected. These 23 patients were the source of tumor material and peripheral blood. Fresh autologous leukocytes were obtained for the assays, from each patient, on the day of surgery and prior to the administration of the preoperative medications. These were tested in vitro, on the same day, with freshly prepared autologous tumor extracts as the source of autologous tumor antigens. The results revealed that the preoperative leukocytes of patients with stage III melanoma expressed hypersensitivity to their tumors, with significant inhibition of their leukocyte migration, compared to those with distant metastases who expressed no such sensitivity, P = 0.012. Such hypersensitized lymphocytes may be capable of producing more efficient lymphokine activated killer (LAK) cells for an effective adjuvant adoptive immunotherapy.
Functional outcome in patients treated with surgery and irradiation for soft tissue tumours
Authors: Bell Robert S. , O'Sullivan Brian , Davis Aileen , Langer Fred , Cummings Bernard , Fornasier Victor L. 
Published: February 2007

AbstractOne hundred five consecutive patients underwent surgical resection and adjuvant irradiation in treatment of soft tissue sarcoma or aggressive fibromatosis. All patients were entered in a prospective study evaluating functional outcome and 88 patients were examined at 12 months following surgery. Outcome was characterized using the Enneking system as well as documenting employment/recreational status and limb edema. Sixty‐eight of 88 patients had functional scores of 21 or better (out of a possible total of 35). Forty‐four patients were serially evaluated at 12 and 24 months and there was no difference in their outcome at the 2 time points. Univariate analysis demonstrated that large tumour size, postoperative complications, and neural sacrifice were associated with poor functional outcome.
Effect of prostaglandin E in multiple experimental models. VIII. effect on host response to metastatic tumor
Authors: Waymack J. Paul , Flescher Eliezer , Venkatraman Jaya , Fernandes Gabriel , Guzman Rey F. , Yurt Roger W. , Mason Arthur D. , Pruitt Basil A. 
Published: February 2007

AbstractProstaglandin E (PGE) is produced by certain tumors and is reported to decrease primary tumor growth. We evaluated its effect in multiple tumor models utilizing a 1 week course of the long acting PGE derivative dimethyl‐PGE (dPGE) at a dosage of 100 μg/kg/day vs. a lactated Ringers control. For all tumor models, a suspension of 1 × 106 colon carcinoma cells were injected into Wistar‐Furth rats. When the suspension was injected subcutaneously and the drug was begun at the time of tumor challenge, there was no effect on survival. When the tumor was injected intraperitoneally or intravenously and the drug begun at the time of tumor challenge, dPGE decreased survival time. When the tumor was administered intravenously but dPGE was delayed for 5 days, there was no effect on survival time. When rats were given a 1 week course of dPGE or saline, dPGE was found not to alter natural killer (NK) cell cytotoxicity, macrophage cytotoxicity, spontaneous lymphocyte blastogenesis, or mitogen stimulated blastogenesis. dPGE failed to alter lymphocyte metabolism of glucose in nonstimulated lymphocytes, but decreased the rate of glucose metabolism and adenosine deaminase activity in mitogen stimulated lymphocytes. In conclusion, PGE appears to enhance metastatic growth of tumor lines where it does not alter primary tumor growth. This effect does not appear immunologically mediated.
Combining independently effective anticancer agents may not augment the independent antitumor effects: A study using human digestive organ cancer xenograft lines in nude mice
Authors: Nio Yoshinori , Tseng Chen‐Chiu , Tsubono Michihiko , Kawabata Kazuya , Masai Yoshikazu , Shiraishi Takahiro , Fukumoto Manabu , Tobe Takayoshi 
Published: February 2007

AbstractFive human digestive organ cancer xenograft lines were subcutaneously transplanted in nude mice, and 7 anticancer agents (ACAs) were intravenously administered singly or in combinations at 4 times the standard clinical doses. Cisplatin (P) was effective in 4 lines and 5‐fluorouracil (F) was effective in 3 lines. A total of 8 combinations with 2 effective ACAs were assessed in 4 lines and only 1 combination (FP) resulted in an augmented antitumor effect in a single line. A total of 11 combinations with 1 effective ACA plus 1 ineffective ACA were assessed in 2 lines, and only 1 combination (F + carboquone [CQ; Esquinon]) resulted in an augmented effect in a single line. A total of 5 combinations with independently ineffective ACAs were assessed in 1 line, and 1 combination (FP) resulted in augmented antitumor activity. No 2‐ACA combinations showed enhanced side effects. Two combinations with 3 effective ACAs were assessed in 2 lines and 1 combination (FP + mitomycin C) resulted in an augmented effect with a greater mortality rate. A total of 12 combinations with both effective plus ineffective ACAs were assessed in 2 lines, and 3 combinations (FP + Adriamycin or FP + CQ or FP + etoposide) resulted in an augmented effect in 1 line with enhanced side effects. These results indicate that the combination of independently effective ACAs does not always cause an augmented antitumor effect, and may sometimes result in augmented side effects. According to this study, the 3‐ACA combinations with FP + 1 effective agent appear to be the best regimens for digestive organ cancer.
p53 alterations in all stages of breast cancer
Authors: Davidoff Andrew M. , Kerns Billie‐Jo M. , Pence Jeffrey C. , Marks Jeffrey R. , Iglehart J. Dirk 
Published: February 2007

AbstractOverexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 73 (25%) of 291 primary invasive carcinomas, 13 (50%) of 26 lymph nodes containing metastatic breast cancer, and two of four established breast cancer cell lines. Sequence analysis of selected specimens confirmed that p53 overexpression was associated with mutation of the gene, while no mutations were detected in specimens without p53 overexpression. Thus, overexpression of p53 occurs in all stages of breast cancer and is consistently associated with the production of mutant proteins. Immuno‐histochemical analysis is a simple method which reliably predicts the presence of most p53 gene mutations in breast cancer specimens.
Intermediate lymphocytic lymphoma: Its frequency and characteristics in japan
Authors: Aozasa Katsuyuki , Ohsawa Masahiko , Horiuchi Keisuke , Myoui Akira , Kawano Kiyoshi 
Published: February 2007

AbstractThe nature of intermediate lymphocytic lymphoma (ILL) in Japan was investigated. For this purpose, we have reviewed 1,766 cases of malignant lymphoma and related diseases, and 38 cases were selected as ILL. In two cases, small lymphoid cells proliferated as a wide mantle of atrophic secondary follicles. The frequency of ILL in nodal and extranodal non‐Hodgkin's lymphoma was 3.4% and 3.9%, respectively. The frequency was high in orbit and salivary gland lymphomas; two out of three cases and one out of six cases, respectively. Age range (median) and sex ratio (M:F) in nodal and extranodal cases were 34–65 (52) years and 2.1:1 and 22–82 (61) years and 1.1:1, respectively. The majority of nodal ILL presented as systemic disease, but extranodal ILL usually presented as localized disease. ILL when treated with chemotherapy and/or radiotherapy had a favorable prognosis, the 5‐year survival rate was 82%.
Bilateral renal oncocytomas: Management and nuclear analysis
Authors: Stuart Wolf J. , Carroll Peter R. 
Published: February 2007

AbstractOnly 16 cases of bilateral renal oncocytomas have been previously reported in the English language literature, 9 of which were treated with bilateral surgical resections. We report a case treated with bilateral partial nephrectomy. Although pathological examination revealed grade I oncocytomas on both sides, flow cytometry demonstrated tumor DNA content to be aneuploid on one side and diploid on the other, the first cellular differences reported in a case of bilateral renal oncocytomas. The management of suspected renal oncocytomas is discussed, with emphasis on the need for complete excision in most patients. The results of nuclear studies of these tumors, including DNA flow cytometry, cytogenetics, and molecular analysis of both nuclear and mitochondrial DNA, are reviewed.