bluuebunny/crossref_metadata_2025_split huggingface dataset:
TGFBR3 loss and consequences in prostate cancer
Authors: Sharifi Nima , Hurt Elaine M. , Kawasaki Brian T. , Farrar William L. 
Published: December 2006

AbstractBackgroundResistance to transforming growth factor‐beta (TGF‐β) is important in tumorigenesis. TGF‐β resistance mechanisms in prostate cancer are not well understood.MethodsWe have conducted a systematic analysis of TGF‐β pathway components with a meta‐analysis of seven microarray studies using Oncomine and evaluated the results of TGFBR3 expression in prostate cell lines. Furthermore, we knocked down TGFBR3 in prostate epithelial cells and analyzed the consequences of TGFBR3 knockdown.ResultsWe found that TGFBR3 is the TGF‐β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. DNA microarray analysis of TGFBR3 knockdown cells identified 101 genes regulated by TGFBR3. Seven of these genes show a corresponding decrease in clinical prostate cancer specimens, which include genes involved in prostate mass and vasculature.ConclusionsTGFBR3 downregulation is an important step in prostate tumorigenesis. Prostate 67:301–311, 2007. © 2006 Wiley‐Liss, Inc.
Promoter hypermethylation of GSTP1, AR, and 14‐3‐3σ in serum of prostate cancer patients and its clinical relevance
Authors: Reibenwein Jochen , Pils Dietmar , Horak Peter , Tomicek Birgit , Goldner Gregor , Worel Nina , Elandt Katarzyna , Krainer Michael 
Published: December 2006

AbstractOBJECTIVEHypermethylation of tumor suppressor genes (TSG) is thought to play an important role in tumorigenesis of prostate cancer. The main focus of research was the detection of TSG hypermethylation in cancer tissue. Our aim was to evaluate the feasibility of detection of hypermethylated genes in serum of prostate cancer patients and its correlation with clinicopathological parameters.METHODSOne hundred twenty‐five serum samples from 62 patients with hormone refractory prostate cancer (HRPC), 14 patients with early disease, and 49 healthy controls were examined. After DNA extraction and sodium‐bisulfite treatment, conventional methylation‐specific PCR (MSP) was performed for glutathione S‐transferase P1 (GSTP1), androgen receptor (AR), and 14‐3‐3σ.RESULTSIn serum of HRCP patients, frequency of GSTP1, AR, and 14‐3‐3σ hypermethylation was 32.2, 40.3, and 86.6%, respectively. In serum of patients with early disease frequency of GSTP1, AR, and 14‐3‐3σ, hypermethylation was 21.4, 35.7, and 85.7%. In healthy controls, frequency of GSTP1, AR, and 14‐3‐3σ hypermethylation was 0, 26.5, and 55.1%, respectively. There was a significant increase of frequency of TSG hypermethylation for GSTP1 and 14‐3‐3σ in HRPC patients, in comparison with healthy controls. GSTP1 hypermethylation in HRPC patients was significantly correlated with differentiation of cancer and metastatic disease.CONCLUSIONSHypermethylation of TSG can be detected in serum of prostate cancer patients. Some hypermethylated TSG can be detected in serum of healthy controls. GSTP1 was not detectable in controls and correlated significantly with Gleason score and stage of disease. Therefore, this gene may be a promising new tool in prostate cancer diagnosis. Prostate 67: 427–432, 2007. © 2006 Wiley‐Liss, Inc.
Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer
Authors: Ramankulov Azizbek , Lein Michael , Kristiansen Glen , Loening Stefan A. , Jung Klaus 
Published: December 2006

AbstractBackgroundThe study was undertaken to evaluate the diagnostic and prognostic value of plasma osteopontin (OPN) in comparison to bone markers as well as the relationships between the markers and clinico‐pathological factors in prostate cancer (PCa) patients.MethodsOPN and the bone markers carboxyterminal‐telopeptide of type I collagen, bone‐specific alkaline phosphatase (bALP), and aminoterminal‐propeptide of type I procollagen (PINP) were measured in 90 PCa patients with and without bone metastases, 35 patients with benign prostatic hyperplasia, and 29 healthy men.ResultsOPN and bone markers were significantly elevated in patients with bone metastases compared to the other groups. Significant correlations were found between all four‐bone markers (rs = 0.43–0.79, all P < 0.01). OPN correlated with tumor grade (rs = 0.23, P < 0.05). In receiver‐operating characteristics (ROC) analyses, OPN and bone markers were effective in distinguishing PCa patients with and without bone metastases showing areas under the curve (AUC) between 0.80 and 0.88 (all P < 0.001). OPN had an AUC of 0.85 that increased in combination with bALP up to 0.93 providing at the point with the highest diagnostic accuracy both a sensitivity and specificity of about 90%. Kaplan–Meier analyses and Cox proportional hazards regression models showed decreased survival of patients with high OPN and bone marker levels, while only high OPN and PINP were independent negative prognostic factors for PCa‐related death.ConclusionsOPN alone or in combination with bone markers is useful as diagnostic marker in the detection of bone metastases and as prognosticator in the survival prediction in PCa patients. Prostate 67:330–340, 2007. © 2006 Wiley‐Liss, Inc.
The value of different screening tests in predicting prostate biopsy outcome in screening for prostate cancer data from a multicenter study (ERSPC)
Authors: Roobol M.J. , Zappa M. , Määttänen L. , Ciatto S. 
Published: December 2006

AbstractBACKGROUNDAlthough serum PSA testing is widely used as a screening test for prostate cancer (PC), it is known that it is not specific for PC. The study described here focuses on the value of screening tests next to PSA in identifying men with an elevated risk of having PC and the differences between three centers of the European Randomised study of Screening for Prostate Cancer (ERSPC).METHODSThe study population consists of 2,483 men with a PSA ≥4.0 ng/ml, all biopsied. We assessed data on age, serum PSA level at initial and repeat screening, prostate volume, number of positive DRE and TRUS findings, number of previous negative biopsies, and PPV of the three centers and overall. Using logistic regression analysis, predictors for biopsy outcome at repeat screening in men with a PSA value ≥4.0 ng/ml were determined on the complete dataset and per center.RESULTSIn 2,483 men biopsied, 665 cancers were detected (PPV = 26.8%). Data show that all predictors except prostate volume loose their predictive value in men previously biopsied. In men not previously biopsied, the predictive value of DRE and TRUS vary considerably among the three centers.CONCLUSIONSLooking at the differences in the predictive value of screening tests in three “comparable” centers, generasibility is not as straightforward as it seems. Using a nomogram for predictive purposes developed elsewhere will require a thorough knowledge of the patient population of which it is derived, and one should interpret its results with a critical mind. Prostate 67: 439–446, 2007. © 2006 Wiley‐Liss, Inc.
Thermal emission and other characteristics of large liquefied natural gas fires
Authors: Malvos Hugues , Raj Phani K. 
Published: December 2006

AbstractThree 35‐m diameter liquefied natural gas (LNG) fire tests were conducted on an insulated concrete dike in July and September of 1987. Although details of the test setup and instruments were previously reported, only limited data were published. This article presents additional data, especially of the radiant heat output of the fire, and other important results. The fire emissive power obtained from the wide angle and narrow angle radiometer data are compared with similar results from other field tests. The importance of these results in modeling the behavior of large LNG fires and predicting the thermal emissions from fires postulated to occur from large LNG releases is discussed. Also indicated in this article are the data on the spectral emission from the 35‐m diameter LNG fires. Analysis and comparison with similar data from the China Lake LNG fire on water tests are provided. © 2006 American Institute of Chemical Engineers Process Saf Prog, 2007.
Linear deformation effect on the SWR acoustic mode in La0.67Ca0.33MnO3 manganite film
Authors: Shapovalov V. , Dyakonov V. , Aleshkevych P. , Dyakonov K. , Zhikharev I. , Kuzminski M. , Szymczak H. 
Published: December 2006

AbstractIn this work, the influence of linear deformation on the magnetic resonance spectrum including the surface spin wave mode in La0.67Ca0.33MnO3 manganite film grown on LiNbO3 substrate has been investigated using a microwave technique. The parameters of the spectrum are established to depend strongly on strains in the film that influence both the profile of the magnetic resonance spectrum and the mode position and intensity. The magnetostriction constants of both the bulk film and surface mode were first determined using the shift of resonance fields as a function of mechanical stress. The tensile strain is shown to favor excitation of the surface spin‐wave mode, and its influence is stronger on the film surface layer. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Carrier injection as a cause of THz lasing excitation in SiGe/Si QW structures
Authors: Kagan M. S. , Altukhov I. V. , Sinis V. P. , Paprotskiy S. K. , Yassievich I. N. , Kolodzey J. 
Published: December 2006

AbstractThe evolution of THz emission, current and probe voltage in SiGe‐QW laser structures at the leading front of voltage pulse was studied. The excitation of stimulated THz emission is shown to be the result of electron injection through contacts and/or n‐Si substrate. The mechanism of intra‐center population inversion caused by carrier injection is suggested. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Preface: phys. stat. sol. (b) 1/2007
Authors: Muñoz Alfonso , Christensen Niels E. 
Published: December 2006

AbstractThis issue of physica status solidi (b) contains the Proceedings of the 12th International Conference on High Pressure Semiconductor Physics (HPSP‐12) which took place in Barcelona, Spain, on 31 July– 3 August 2006. The meeting was held at the CosmoCaixa Museum (see also the Conference Report and Concluding Remarks by M. Cardona at the end of this issue [1]). HPSP‐12 was a satellite conference to the 28th International Conference on the Physics of Semiconductors held in Vienna, Austria, 24–28 July 2006. Around 125 scientists were registered at HPSP‐12, and 89 papers were submitted to the Proceedings. These describe recent research on various physical properties under pressure like optical absorption, vibrational states, structural transformations, transport properties, electronic structures, superconductivity, among others. The materials and solid state systems examined include bulk, crystalline materials of various compositions, alloys (diluted nitrides), quantum‐well structures, quantum dots, fullerenes and carbon nanotubes, microrods, devices like lasers, etc. Interesting results were presented in several experimental papers as well as in accounts of theoretical work.HPSP‐12 was supported financially by the Spanish Ministry of Education and Science (MEC), Obra Social Fundació “la Caixa”, Fundación BBVA, Consejo Superior de Investigaciones Científicas (CSIC), m.t. Brandão España s.l., Generalitat Valenciana, Carburos Metálicos S.A., Universitat de València, and Universidad de La Laguna.We are very grateful to the local organizers and thank the Program and International Advisory Committees. Not least, we thank the many reviewers who submitted their detailed referee reports within short notice.The agreement with the publishers Wiley‐VCH on the publication of the proceedings of the HPSP conferences is very important, in particular because the papers are reviewed as for a usual international journal. This ensures a high standard of the accepted papers. However, the quality of the research presented is closely related to how the HPSP community itself defines the scope of its meetings. One might ask, whether the subjects, which in the past have been very successful in defining the programs of the HPSP conferences, could in part be exchanged with new fields in order to adjust more to new developments in condensed matter research. The next HPSP conference, number 13, will be held in Fortaleza, Brazil, 21–28 July 2008. This gives time for all of us to suggest new directions and offer assistance to the organizers (Chair: Prof. V. Lemos).September 2006
Raman study of β‐Sr0.33V2O5 micro‐crystals under high pressure
Authors: Kontos A. G. , Lampakis D. , Popović Z. V. , Raptis Y. S. , Liarokapis E. , Isobe M. , Ueda Y. 
Published: December 2006

AbstractThe cover picture of the current issue relates to the article by A. G. Kontos et al. [1]. The authors study the phonon dynamics of the strontium vanadium oxide bronze β‐Sr0.33V2O5 by Raman spectroscopy at different temperatures under high pressure up to 5.7 GPa. The material, which undergoes a metal–insulator phase transition at TMI ≈ 165 K associated with charge ordering, consists of a V2O5 framework of three kinds of infinite double chains along the b‐axis with three different sites, V1, V2 and V3, for vanadium atoms in six‐fold octahedral and five‐fold coordination, respectively. The Sr cations are located at the sites in the tunnel formed by the V2O5 framework. The corresponding author Yannis S. Raptis is Associate Pro‐ fessor at the Physics Department of the National Technical University of Athens (NTUA). His research interests include the study of optical and lattice‐dynamic properties of materials and their pressure dependence.The article is a presentation from the 12th International Conference on High Pressure Semiconductor Physics (HPSP‐12)
held in Barcelona, Spain, 31 July–3 August 2006 whose proceedings are published in this issue of physica status solidi (b).
Simplest proof of the Jahn–Teller theorem for molecular systems
Authors: Pupyshev Vladimir I. 
Published: December 2006

AbstractA new simple proof of the Jahn–Teller theorem for molecular systems is presented. The proof is based on some general properties of symmetric square representation characters that simplify their explicit treatment and minimize the use of tables. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
The effect of human resource management policies on organizational performance in Greek manufacturing firms
Authors: Katou Anastasia A. , Budhwar Pawan S. 
Published: December 2006

AbstractThis article investigates if human resource management (HRM) policies have an impact on organizational performance in the Greek manufacturing context. The research is based on a sample of 178 firms. The “universalistic model” of HRM is adopted to conduct the investigation. The results show strong support for the model, indicating that the HRM policies of recruitment, training, promotion, incentives, benefits, involvement, and health and safety are positively related with organizational performance. The study both contributes to HRM theory and has important implications for practitioners. © 2007 Wiley Periodicals, Inc.
Foreign direct investment: A strategic move toward sustainable free enterprise and economic development in Saudi Arabia
Authors: Ramady Mohamed A. , Saee John 
Published: December 2006

AbstractForeign direct investment (FDI) has been viewed in many circles as one of the key drivers for economic development. Irrespective of their ideological differences, most countries around the world have been competing to attract FDI. China, for example, is a country formally characterized by communist ideology. It has been highly proactive in formulating policies amenable to FDI so much so that in 2003, China overtook the United States as the biggest recipient of FDI, having attracted U.S. $53 billion from Organisation for Economic Co‐operation and Development (OECD) countries and elsewhere.In this article, an attempt is made to critically examine aspects of FDI, especially with reference to economic development in Saudi Arabia. The research study in this article reports new research findings based on a survey of Saudi managers/enterprises that highlight the current status of FDI in the Kingdom of Saudi Arabia. In particular, the study finds that while Saudi managers generally welcome FDI into the country, at the same time, they do retain ambivalent attitudes toward its perceived benefits.
An evaluation of the perceptions and marketing practices of nontraditional exporters in Ghana
Authors: Owusu‐Frimpong Nana , Mmieh Frederick 
Published: December 2006

AbstractThis article evaluates the marketing practices of nontraditional exporters (NTEs) and their perceptions of the Ghanaian government's export promotional activities and prescribes a procedure for export promotion for the country. The result shows that from a sample of 92, over 73% of respondents are from woodwork, textiles, and agricultural production. NTEs account for over 24% of the country's total exports. The Ghana Export Promotions Council (GEPC) and exhibitions are perceived to be the most effective sources of information by the exporters. Evidence shows that exporters consider growth and profit opportunities that are proactive motives as the most important factors for initiating exporting. Over 50% of the respondents have no formal planning procedures or set of objectives, and about 13% achieve a turnover of over U.S.$6 million. The application of the marketing concept by the respondents is at an embryonic stage. The exporters consider high banking charges, low capacity usage, and poor technology as the major problems that affect their business operations. © 2007 Wiley Periodicals, Inc.
Consumer change in Japan: A longitudinal study
Authors: Reid David McHardy 
Published: December 2006

AbstractJapan has been in a recession for the better part of 15 years and has experienced some subtle and less subtle changes. The identification and interpretation of these developments offers challenges and opportunities. The research outlined in this article sets out to identify change and informs on the ever‐changing behavior of the Japanese consumer. It is based on a study of the pre‐ and postbubble changes in Japan at key epochs: 1990, 1995, 1998, and 2003. The study involved 80 personal interviews and meetings drawn from 67 organizations. The analysis, employing Grounded Theory, compares the current status with earlier intervals. © 2007 Wiley Periodicals, Inc.
Investment dealers' ways of working: Integrating compensation with relational capital
Authors: Kakabadse Andrew P. , Kakabadse Nada K. , Lake Amielle 
Published: December 2006

AbstractFor the past 20 years, practitioner and academic research has highlighted that the performance of companies is linked to staff and management's ways of working, particularly in service‐oriented enterprises (A. P. Kakabadse, Savery, Kakabadse, & Lee‐Davies, 2006). Yet despite the monumental impact that financial institutions have on a nation's economy, few studies have examined the ways of working of investment dealers. In the finance literature, two distinct bodies of thought have endeavored to grasp the enigmatic nature of financial markets, investor behavior, and investment decision making. These are, on the one hand, the more traditional finance theories and, on the other, behavioral theories that examine, respectively, the quantitative and qualitative psychological attributes of individually driven investment decisions. Yet it appears that both areas do not meaningfully consider the impact of contextual dynamics on investment decisions (A. Kakabadse, 2000). In response, this article attempts to redress this imbalance by presenting emerging findings from 41 interviews with corporate finance specialists and managers employed in retail and institutional broker departments. Presented is an array of evidence highlighting that employees' ways of working are influenced by investment‐related demographics—namely, structure of compensation and the disciplined pursuit of relational capital. © 2007 Wiley Periodicals, Inc.
Norge electronics (Portugal), S.A
Authors: McGuire Stephen J. J. 
Published: December 2006

AbstractThe case begins with the protagonist, João Silva, in Oslo for a meeting of personnel directors of the subsidiaries of a large Scandinavian multinational, Norge Electronics. Silva is the administrative director (Finance and Administration, HR, Legal) of the division's smallest subsidiary—Norge Electronics Portugal. Silva had been asked by the vice president of human resources to present to the personnel directors what has been achieved in Portugal. The evening before his presentation, Silva received a fax from a consultant he hired in Portugal with the preliminary results of a climate study. The consultant's report is not what Silva expected and, in fact, raises questions about the effectiveness of a series of change actions implemented over the past two years. The case describes in detail the actions taken by Silva to “professionalize” HR management in the Portuguese subsidiary. © 2007 Wiley Periodicals, Inc
The end1 gene of Schizosaccharomyces pombe coding for a DNase is identical with the pnu1 gene coding for an RNase
Authors: Kohli Jürg , Sakem Benjamin 
Published: December 2006

AbstractThe DNA nuclease activity encoded by the end1 gene, and its inactivation by mutation, was described in connection with the characterization of DNA topoisomerases in the fission yeast Schizosaccharomyces pombe (Uemura and Yanagida, 1984). Subsequently, end1 mutant strains were used for the preparation of cell extracts for the study of enzymes and intermediates involved in DNA metabolism. The molecular identification of the end1 gene and its identity with the pnu1 gene is presented. The end1‐458 mutation alters glycine to glutamate in the conserved motif TGPYLP. The pnu1 gene codes for an RNase that is induced by nitrogen starvation (Nakashima et al., 2002b). Thus, the End1/Pnu1 protein, like related mitochondrial proteins in other organisms, is an example of a sugar‐non‐specific nuclease. The analysis of strains carrying a pnu1 deletion revealed no defects in meiotic recombination and spore viability. Copyright © 2007 John Wiley & Sons, Ltd.
Factors involved in anaerobic growth of Saccharomyces cerevisiae
Authors: Ishtar Snoek I. S. , Yde Steensma H. 
Published: December 2006

AbstractLife in the absence of molecular oxygen requires several adaptations. Traditionally, the switch from respiratory metabolism to fermentation has attracted much attention in Saccharomyces cerevisiae, as this is the basis for the use of this yeast in the production of alcohol and in baking. It has also been clear that under anaerobic conditions the yeast is not able to synthesize sterols and unsaturated fatty acids and that for anaerobic growth these have to be added to the media. More recently it has been found that many more factors play a role. Several other biosynthetic reactions also require molecular oxygen and the yeast must have alternatives for these. In addition, the composition of the cell wall and cell membrane show major differences when aerobic and anaerobic cells are compared. All these changes are reflected by the observation that the transcription of more than 500 genes changes significantly between aerobically and anaerobically growing cultures. In this review we will give an overview of the factors that play a role in the survival in the absence of molecular oxygen. Copyright © 2007 John Wiley & Sons, Ltd.