bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free jejunal graft for repair of cervical esophagus
Authors: Sohrabi A. , Nowzari Pourandokht , Ashairi M. , Moghari A. , Watne Alvin 
Published: February 2007

AbstractWe have operated upon six patients with cervical esophageal carcinoma and reconstructed these with free jejunal graft. The pathology of all six patients was squamous cell carcinoma, and no patient had apparent distant metastasis. The procedure was a two team approach. While the surgical oncology team resected the esophageal tumor, the microvascular team harvested the jejunal graft. The range of warm ischemia for the free jejunal graft was 1‐2.5 hr, and no graft was lost because of recirculation failure. The range of operative time was 5‐6.5 hr. There was no operative mortality. There were two minor cervical wound infections, both healed with conservative management. Hospital stay ranged from 10 to 15 days. The swallowing mechanism was satisfactory in all patients. We believe that the free jejunal graft is the procedure of choice for reconstruction of the cervical esophagus.
Subclinical primary liver carcinoma
Authors: Li Guo‐Hui , Li Jin‐Qing 
Published: February 2007

AbstractFrom 1976 to 1984, 30 cases of asymptomatic primary liver cancer (subclinical primary liver cancer) have been treated in our hospital. The most important approaches used to uncover subclinical primary liver cancer were (1) the use of alpha‐fetoprotein (AFP) monitoring in patients with liver disease; (2) the use of an AFP survey among high‐risk area populations; and (3) X‐ray examination of the diaphragm and sonography examination.The resectability rate of this series was 50%. The 3 and 5 year survival rates after hepatectomy were 62.5 and 57.1%, respectively. Hepatic arterial ligation combined with irradiation for the nonresectable cases had a better result.We discuss here the approaches and the diagnostic criteria of subclinical primary liver cancer.
Effects of intratumoral injection of I‐125 lododeoxyuridine on ehrlich ascites carcinoma
Authors: Hong Seong Su , Ford Edith H. , Alfieri Alan A. , Bravo Sergio 
Published: February 2007

AbstractIntratumoral injection of I‐125 iododeoxyuridine (IUdR), saline solution, and oil suspension was investigated using Ehrlich ascites tumors in the thighs of mice. The oil suspension was more effective in tumor growth delay than was the saline solution. Single injection of the oil suspension at the dose of 12.5 μCi resulted in 21.5 days growth delay, whereas 50 μCi of the saline solution resulted in 11.5 days growth delay relative to control growth delay.At 40 days after treatment, higher radioactivities were observed in the tumor and the skin of the mice treated with the oil suspension, which represented the prolongation of I‐125 IUdR oil suspension within the tumor. No normal tissue toxicities were observed.
Hamartoma of the breast
Authors: Riveros Manuel , Cubilla Antonio , Perotta Francisco , Solalinde Victor 
Published: February 2007

AbstractMammary hamartomas are unusual lesions with distinctive radiologic and pathologic features. They are well circumscribed, mobile tumors showing no adherence to skin or muscle. Mammographic studies show a peripheral, luscent halo, and the mass is radiographically similar in pattern to a normal breast (“breast within a breast”). Calcification is not present. Histologically, these encapsulated lesions are composed of various breast tissue components such as ducts, lobules, stroma prominently adipose, and smooth muscle, without any particular arrangement. Local surgical resection is the treatment of choice. Hamartomas of the breast are benign lesions that need to be distinguished from other breast neoplasms such as fibroadenomas, lipomas, and cystosarcoma phyllodes.
Ocular melanoma in alberta: A 38 year review pointing to the importance of tumor size and tumor histology as predictors of survival
Authors: Hayton Susan , Lafreniere Rene , Jerry L. Martin , Temple Walley J. , Ashley Pauline 
Published: February 2007

AbstractA large number of cases of ocular melanoma have been entered in The Provincial Cancer Registry of Alberta over the past 40 years. This study was undertaken in order to describe further the natural history of this disease and derive management recommendations for use at the provincial level. A retrospective chart review was carried out on all cases of ocular melanoma registered through The Alberta Provincial Cancer Registry between 1949 and 1987. Two hundred fifty‐one cases were identified: 143 were males and 108 were females. The mean age of the patients at diagnosis was 60. The majority of the melanomas arose from the choroid of the eye (82%) with the remainder arising from the iris, conjunctiva and ciliary body, respectively. According to the Callender classification for ocular melanomas, the majority of the melanomas were of the spindle cell type (53%), the others being either mixed cell (23%), epithelioid (8%), or fascicular (1%). Survival rates differed depending on the cell type. Spindle cell tumors demonstrated a mean survival time of 5.2 years; epithelioid tumors 4.8 years and the mixed cell tumors appeared to be the most aggressive with a mean survival time of 2.7 years after diagnosis. The majority of deaths from ocular melanoma occurred within 5 years of diagnosis, although 14% of patients in this review presented with metastases more than 10 years after diagnosis. Some of the cases of ocular melanoma could be classified pathologically as small, medium, or large. Patients with large ocular melanomas had a 5 year survival rate of 33% compared to 70% and 66% for patients with small and medium sized tumors. Of note, 43% of patients with large ocular melanomas who were dead from their disease within 5 years of diagnosis were also found to have mixed cell tumors. These findings call for a longer follow‐up period for ocular melanomas and point to the importance of cell type and tumor size as predictors of survival and as guides in planning prophylactic therapeutic interventions.
Role of intraoperative ultrasound in the screening of liver metastases from colorectal carcinoma: Initial experiences
Authors: Russo Antonio , Sparacino Giulio , Plaja Sergio , Cajozzo Massimo , la Rosa Carmelo , Demma Ignazio , Bazan Pietro 
Published: February 2007

AbstractThe aim of this study was to assess the utility of intraoperative ultrasound (IOUS) in the diagnosis and management of liver metastases from colorectal carcinoma. IOUS was performed on a consecutive series of 70 patients undergoing surgery for colorectal carcinoma, with follow‐up ranging from 6 to 24 months. In ten cases (14.3%), 13 metastatic tumours were diagnosed; only six of these had been found by preoperative workup and/or surgical inspection. Seven (53.9%) small metastatic liver lesions were identified only by IOUS. None of the lesions diagnosed by IOUS was palpable, and they were all extremely small—ranging from 4 × 6 to 12 × 16 mm. Seventy‐three locations were examined in order to compare the results of IOUS with those of other methods. The sensitivity of the former proved to be higher (P < .05) than that of conventional pre‐ and intraoperative screening.
Calcitonin gene‐related peptide in patients with endocrine tumors
Authors: Takami Hiroshi , Shikata Jun‐Ichi , Kakudo Kennichi , Ito Kunihiko 
Published: February 2007

AbstractThe plasma level of calcitonin gene‐related peptide (CGRP) was measured by RIA in 41 patients with endocrine tumors [22 medullary thyroid carcinomas (MTC), seven parathyroid adenomas, four benign insulinomas, five carcinoids, and three pheochromocytomas]. Of the 22 patients with MTC, all five preoperative patients had elevated CGRP levels. The correlation between CGRP and calcitonin levels was significant (P < .001) in 22 patients with MTC. Six of 19 patients with endocrine tumors other than MTC showed elevated CGRP levels. Immunohistochemical study showed that tumor tissues from all 22 cases of MTC and seven from other endocrine tumors contained immunoreactive CGRP. CGRP reactivity was found in only small numbers of tumor cells. Thus, although CGRP appeared to be a useful additional marker for MTC, the role of CGRP in the pathophysiology of endocrine tumors was not elucidated.
In vivo administration of Picibanil (OK‐432) prior to tumor harvest leads to an enhancement of tumor‐infiltrating lymphocyte (TIL) cytotoxicity
Authors: Lafreniere Rene , Borkenhagen Knut , Bryant Laurette D. 
Published: February 2007

AbstractTILs can be isolated and expanded in vitro in the presence of RIL‐2. The resulting cells are highly cytotoxic in vitro and in vivo against a variety of tumor targets. Although most of the TILs bear T cell antigens on their cell surface, recent evidence suggests that natural killer (NK) cells may be part of the overall population of infiltrating cells. Based upon this evidence, we have evaluated the effects of Picibanil (OK‐432), a well‐known inducer of NK cell and T cell cytotoxicity, on TILs. OK‐432 was administered intravenously at a dose of 100 μg, previously determined to be optimal for NK stimulation, to tumor‐bearing animals. Two days later, control and experimental animals had their tumors harvested and processed in order to grow their TILs in vitro in complete medium containing RIL‐2 at a final concentration of 1,000 U/ml. The following observations were made: 1) a greater than 300% increase in overall TIL number compared to controls on day 10 of culture returning to normal by day 30; 2) a marked increase in the percent of cells expressing cytotoxic and differentiation antigens in the experimental group compared to controls, such increase seen mostly from day 7 to day 10; 3) a marked increase in the cytotoxic activity of the experimental TILs against an NK‐sensitive tumor target, the YAC‐1 lymphoma, throughout the period of growth of the TILs (3–4 times controls) and to a lesser extent against an NK‐resistant tumor target. These findings may have potential application in immunotherapeutic trials against human tumors and may help to understand the reasons for the effectiveness of OK‐432 in vivo against selected murine tumors.
Surgical treatment of solitary adrenal metastases from lung carcinoma
Authors: Raviv Gil , Klein Ehud , Yellin Alon , Schneebaum Shlomo , Ben‐Ari Gur 
Published: February 2007

AbstractThe adrenal gland is a frequent site for metastases from lung carcinoma. We have treated five patients with a solitary symptomatic mass in the adrenal by palliative adrenalectomy with fair results. These case reports and discussion of the literature are presented.
Improved survival after pulmonary resection of metastatic colorectal carcinoma
Authors: Sauter Edward R. , Bolton John S. , Willis Gladden W. , Farr Gist H. , Sardi Armando 
Published: February 2007

AbstractWhile hepatic resection of metastatic colorectal carcinoma is accepted as effective in selected patients, resection of metastases to other solid organs has not gained wide acceptance. We retrospectively reviewed the records of 49 patients who had resection of isolated pulmonary (18 patients) and hepatic (31 patients) metastases from the large bowel, comparing diseasefree survival and overall survival. Tumor parameters analyzed included Dukes' stage, deoxyribonucleic acid (DNA) flow cytometry, and number of metastases. Dukes' B and diploid tumors had longer disease‐free survival and overall survival than did Dukes' C and aneuploid tumors, though the difference was not significant. Patients with a single lung metastasis had a significantly longer disease‐free survival (P = .02) than did patients with multiple metastases. Mean and median survival were longer in patients with lung metastases. Five‐year actuarial survival was 19% for patients with liver metastases and 47% for patients with lung metastases. Resection of isolated pulmonary metastases from the large intestine results in survival comparable to or better than resection of hepatic metastases. An aggressive surgical approach is warranted in patients with isolated resectable pulmonary metastases of colorectal carcinoma.
Experimental study and clinical application of a single‐row suturing esophagogastrostomy
Authors: Gao Shang‐Zhi , Wang Tu‐Sheng , Yao Zhen , Cheng Bang‐Chang , Tu Zhong‐Fan , Ling Dao‐Ming , Peng Shang‐You 
Published: February 2007

AbstractA single‐row suturing anastomosis (SRA) for an esophagogastrostomy was experimentally investigated in dogs. SRA not only shortened operating time, but also led to better pathological results when compared with double‐row suturing anastomosis. Wide‐brim suturing and equal distance between the sutures, providing increased and well‐distributed blood circulation, are the key points for success of SRA. Its simplicity and safety are advantages of SRA as has been shown in 90 cases in clinical application.
Separate annular strictures of the rectosigmoid colon secondary to unsuspected prostate cancer
Authors: Culkin Daniel J. , Demos T. C. , Wheeler J. S. , Castelli M. , Canning J. R. 
Published: February 2007

AbstractRectal involvement from prostate cancer occurs in 1.5–11% of cases. A rarer presentation is that of a separate metastasis to the high rectosigmoid colon causing an annular stricture. We present our experience with six such cases who presented with gastrointestinal symptoms. Two of the cases had undergone intestinal resections. All 6 patients had radiographic evidence of an annular stricture in the rectosigmoid area. Retrospective review revealed evidence of metastatic disease in all cases in the form of abnormalities in one or more of the following: intravenous urography, radionuclide bone scan, liver spleen scan, acid phosphatase, or alkaline phosphatase. The mean survival was 9.3 months. This rare presentation of prostate cancer may be difficult to distinguish from primary colorectal cancer and therefore needs to be ruled out to avoid intestinal resections.
Intrahepatic bile duct cystadenocarcinoma: Case report and imaging diagnosis
Authors: Boillot O. , Domergue J. , Fabre J. M. , Guillon F. , Lestra P. M. , Barneon G. , Bruel J. M. , Baumel H. 
Published: February 2007

AbstractThe authors report the 30th case in the literature of cystadenocarcinoma of the liver and the second case arising in the caudate lobe. This case illustrates the 2 main questions raised by this tumor: the importance of differentiating benign and malignant cystadenoma and bile duct cyst on sonographic and scanographic aspects and the surgical management of these tumors of the liver, especially in this malignant centrohepatic case.
Malignant melanoma metastatic to the thyroid as initial evidence of disseminated disease
Authors: Sheppard Brett C. , Moseley H. Stephens 
Published: February 2007

AbstractA 48‐year‐old Caucasian male with a 3 mm sub‐ungual right middle finger melanoma underwent cisplatin forequarter perfusion, ray amputation, and ipsilateral axillary node dissection. Two months post‐operatively he presented with a thyroid mass as initial evidence of disseminated disease. Subsequent workup also demonstrated pulmonary metastases. A total thyroidectomy radical neck dissection and multi‐agent chemotherapy has controlled the disease in his neck. As far as we are aware, this is the first case report of malignant melanoma metastatic to the thyroid. The potentially beneficial role of surgery in the management of metastatic melanoma and the relation of melanoma to the hormonal axis is discussed.
Abdominal operations for intraabdominal metastases from extraabdominal primary tumors
Authors: Mäkelä Jyrki T. , Kiviniemi Heikki O. , Haukipuro Karl A. , Laitinen Seppo T. 
Published: February 2007

AbstractForty consecutive patients with an extraabdominal primary tumor, later treated surgically for intraabdominal problems, were investigated. The most common causes of abdominal operations were intestinal obstruction (N = 17), intraabdominal tumor mass (N = 8), and intraabdominal hemorrhage (N = 5). The overall postoperative mortality was 25%, morbidity 48%, median survival 3 months, and cumulative 5 year survival 3%. The mortality after emergency procedures, 67%, was significantly higher (P < 0.01) than after elective operations, 18%. Conditions requiring enterostomy (N = 14) were associated with a mortality of 36%, whereas the figures in resected (N = 13) and bypassed (N = 7) patients were 14% and 17%, respectively. Wound infection (N = 5) and pulmonary infection (N = 5) were the most common complications, and pulmonary infection was fatal in three of the five cases. Of the patients, 22 (55%) were discharged from hospital to their home; ten (25%) of them had postoperatively a 3 month relief of cancer symptoms and four (10%) a 6 month relief. Nine patients (25%) have survived for over 1 year and one (3%) for over 5 years. It is concluded that abdominal procedures seldom prevent further cancer growth within these patients and that symptoms are relieved only in one in every four patients. According to strict criteria, these operations are useful and can add to patient comfort.
The value of endoluminal ultrasonography and computed tomography in the staging of rectal cancer: A preliminary study
Authors: Pappalardo G. , Reggio D. , Frattaroli F. M. , Oddi A. , Mascagni D. , Urciuoli P. , Ravo B. 
Published: February 2007

AbstractA prospective study was carried out in 14 patients with rectal cancer. Tumors were staged preoperatively by endoluminal ultrasonography (EU) and computed tomography (CT). Patients were followed postoperatively for 2 years by the same modalities. Extramural spread was 100% (9/9), accurately assessed by EU and 77.8% (7/9) with CT. Lymph node sensitivity was 87.5% for EU and 37.5 for CT (P < 0.05). Overall accuracy of lymph node metastases was 85.7% for EU and 57.1% for CT (P < 0.1). In conclusion, the study shows EU to be statistically more accurate for nodal metastases than CT; therefore, its routine use can be recommended in the preoperative staging of rectal carcinoma in those patients for whom a sphincter‐saving procedure is considered.
Complications following surgery for cancer of the larynx and pyriform fossa
Authors: Sarkar Sudeep , Mehta Samir A. , Tiwari Jitendra , Mehta Ashok R. , Mehta Mona S. 
Published: February 2007

AbstractThe hospital records of patients undergoing major surgery for cancer of the larynx and hypopharynx at the Tata Memorial Hospital, Bombay, from 1981 to 1985 were reviewed. Different variables were correlated with the incidence of major complications and were analysed to find out significant factors contributing to increased complication rates. Complications included wound infection, pharyngocutaneous fistulae, flap necrosis, carotid blowout, and neo‐esophageal stenosis. Postoperative deaths and delayed fatalities were also recorded. The overall fistulae rate was 34.7%, and wound infection occurred in 28% of patients. Prior radiotherapy and the need for pharyngeal reconstruction were found to be significant in determining postsurgical complications. Age. sex, site, stage, cartilage and soft tissue infiltration, preoperative tracheostomy, involvement of resection margins by tumor, and the dose of radiotherapy were not found to influence the complication rates.
Benign schwannoma and parathyroid adenoma occurring in the nonradiated neck: Report of two cases
Authors: Bentt Lavern R. , Silberman Allan W. , Braunstein Glenn D. 
Published: February 2007

AbstractThe late occurrence of multiple neoplasms in the previously radiated neck is a well‐known association. However, multiple tumours in the nonradiated neck remain a rare finding. This paper presents two cases of the infrequently seen schwannoma occurring with a parathyroid adenoma without antecedent history of radiation or neurofibromatosis.
Neuron‐specific enolase during chemotherapy of small cell lung cancer
Authors: Buamah P. K. , Drake S. R. , Smedley H. M. , Bodger W. A. H. , Skillen A. W. 
Published: February 2007

AbstractSerum neuron‐specific enolase (NSE) has been measured in 28 patients with small cell lung cancer (SCLC) and 90 patients with other forms of lung cancer (NSCLC), i.e., 28 with adenocarcinoma and 62 with squamous cell carcinoma. Increased NSE (>12.0 μg/liter) was found in 71.4% of SCLC patients and in 22.2% of NSCLC patients. The predictive value of an increased NSE in identifying SCLC was only 50%, whereas the predictive value of a normal NSE in differentiating SCLC for NSCLC was 91%. Serial studies during chemotherapy of SCLC patients showed that the doubling time of NSE ranged from 7 to 127 days and the mean apparent half‐life (AHL) of NSE to be 14 days. AHL values in excess of 20 days suggest that the tumour is not in full remission. We believe that measurement of serum NSE and calculation of the AHL and DT are valuable in identifying the effectiveness of chemotherapy in patients with SCLC.
Evidence for the existence of different types of large bowel tumor: Suggestions from the clinical data of a population‐based registry
Authors: De Leon Maurizio Ponz , Sacchetti Carla , Sassatelli Romano , Zanghieri Gianni , Roncucci Luca , Scalmati Alessandra 
Published: February 2007

AbstractThe clinical findings of a population‐based colorectal tumor registry have been analyzed to determine elements of supporting or not supporting the existence of different types of large bowel cancer. Age‐specific incidence rate of the 409 registered patients rose sharply with increasing age in all segments of the large bowel; however, regarding left colon and rectum, the male: female ratio showed a marked male preponderance, more evident in the more advanced age groups. Histopathology, studied in 87% of patients, revealed adenocarcinoma as the most frequent feature; however, adenocarcinoma with concomitant adenoma (i.e., presumably arising in adenoma) was observed in 14.3% of cancers of the left colon, in 17.7% of rectal tumors, but in only 5.7% of neoplasms of the proximal colon (P < 0.05 and P < 0.01, respectively, vs. left colon and rectum). Some histological features (carcinoid and mucinous carcinoma) were observed in right‐side tumors only. Analysis of the familial occurrence of cancer showed that a significantly larger proportion of patients with neoplasms located in proximal colonic segments had three or more first‐degree relatives affected by (or deceased from) cancer of all sites. Similarly, colorectal tumors among relatives were more frequent in patients with right‐side cancer. The location of the 793 polyps observed during 3 years of registration showed that more than 70% of adenomas were located beyond the splenic flexure, overlapping the distribution of cancers. In conclusion, the differences of sex ratio at different colonic subsites, the higher fraction of adenocarcinomas with adenomas in cancer of the more distal tracts of the large bowel, and the more marked familial occurrence of colorectal cancer in patients with right‐side neoplasms tend to support the view that cancer of the proximal colon, cancer of the distal colon, and cancer of the rectum may actually be three different types of tumors.
Brachytherapy in the treatment of solitary colorectal metastases to the liver
Authors: Donath D. , Nori D. , Turnbull A. , Kaufman N. , Fortner J. G. 
Published: February 2007

AbstractIt is well‐established that 30–40% of patients with solitary liver metastases from primary colorectal tumors can be cured by resection. Conventional radiation therapy has had only a palliative role in treating liver metastases because the dose that the liver will tolerate is far below a tumoricidal dose. In contrast, brachytherapy allows one to deliver a tumoricidal dose to the tumor while limiting the dose to surrounding normal tissue to the tolerance dose. As a pilot study, 125I seeds were implanted into unresectable hepatic metastases, or positive margins of resection, at the time of surgery. This report concerns six patients whose liver lesions were the only known site of disease and in whom precipitous drops in carcinembryonic antigen (CEA) levels followed the implants. Recurrence was observed in only one of the 11 implanted sites, with a median follow‐up of 12 months.