bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic bone cement accelerates diabetic foot wound healing: Elucidating the role of ROCK1 protein expression
Authors: Yang Chenglan , Wang Dali 
Published: March 2024

AbstractClinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure. Wound healing rate, amputation rate, wound secretion culture and C‐reactive protein (CRP) changes, were monitored. Comprehensive molecular investigations were conducted and animal experiments were performed to further validate the findings. Statistical methods were employed to verify significant differences between the groups and treatment outcomes. The EXP group showed significant improvements in wound healing ( = 11.265, p = 0.004) and reduced amputation rates. Elevated levels of ROCK1, fibroblasts and VGF were observed in the trauma tissue post‐treatment in the experimental group compared to pre‐treatment and the control group (all p < 0.05). Improved trauma secretion culture and CRP were also noted in the EXP group (all p < 0.05). The study suggests that antibiotic bone cement enhances diabetic foot wound healing, possibly via upregulation of ROCK1. Further research is needed to elucidate the underlying molecular mechanisms and broader clinical implications.
Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis
Authors: Chen Hai‐Rong , Lu Shi‐Juan , Wang Qi , Li Ming‐Lan , Chen Xun‐Chun , Pan Bi‐Yun 
Published: March 2024

AbstractHyperbaric oxygen therapy (HBOT) has been used in patients with diabetic foot ulcers (DFU) for many years, but its clinical efficacy is still controversial. Therefore, this study explored the efficacy of HBOT applied to DFU by means of meta‐analysis. PubMed, Cochrane Library, Embase, CNKI and Wanfang databases were searched, from database inception to October 2023, and published randomised controlled trials (RCTs) of HBOT in DFU were collected. Two investigators independently screened the collected literature, extracted relevant data and assessed the quality of the literature. Review Manager 5.4 software was applied for data analysis. Twenty‐nine RCTs with 1764 patients were included. According to the combined results, when compared with conventional treatment, HBOT significantly increased the complete healing rate of DFUs (46.76% vs. 24.46%, odds ratio [OR]: 2.83, 95% CI: 2.29–3.51, p < 0.00001) and decreased the amputation rate (26.03% vs. 45.00%, OR: 0.41, 95% CI: 0.18–0.95, p = 0.04), but the incidence of adverse events was significantly higher in patients (17.37% vs. 8.27%, OR: 2.49, 95% CI: 1.35–4.57, p = 0.003), whereas there was no significant difference in the mortality (6.96% vs. 12.71%, OR: 0.52, 95% CI: 0.21–1.28, p = 0.16). Our results suggest that HBOT is effective in increasing the complete healing rate and decreasing the amputation rate in patients with DFUs, but increases the incidence of adverse events, while it has no significant effect on mortality.
The impact of long‐term antihypertensive treatment on wound healing after major non‐cardiac surgery in patients with cardiovascular diseases: A meta‐analysis
Authors: Liu Yuwei , Ma Chunwei , Tang Xiaoyan , Liu Sha , Jin Yalei 
Published: March 2024

AbstractHypertension is a prevalent condition that poses significant challenges in the perioperative management of patients undergoing major non‐cardiac surgery, particularly concerning wound healing and scar formation. This meta‐analysis assesses the impact of long‐term antihypertensive treatment on postoperative wound healing, examining data from seven studies involving patients who received such treatments compared to untreated controls. Our findings reveal that long‐term antihypertensive therapy is associated with significantly improved wound healing outcomes, as indicated by lower REEDA scores (I2 = 96%, SMD = −25.71, 95% CI: [−33.71, −17.70], p < 0.01) 1 week post‐surgery and reduced scar formation, demonstrated by lower Manchester Scar Scale scores (I2 = 93%, SMD = −37.29, 95% CI: [−44.93, −29.64], p < 0.01) 2 months post‐surgery. These results underscore the potential benefits of antihypertensive treatment in enhancing surgical recovery and offer insights into optimising perioperative care for hypertensive patients.
Biomass production of 14 accessions of cactus pear (Opuntia spp.) under semi‐arid land conditions
Authors: Neupane Dhurba , Niechayev Nicholas A. , Petrusa Lisa M. , Heinitz Claire , Cushman John C. 
Published: March 2024

AbstractIncreased food, feed, and biofuel demands of the future will require a greater reliance upon crop production systems in arid and semi‐arid regions around the world. Diminishing freshwater resources and hotter and drier climatic conditions will also necessitate the use of highly drought tolerant and water‐use efficient crops. Cactus pear (Opuntia ficus‐indica) is a low‐water input, climate‐resilient crop capable of high biomass production due to its use of crassulacean acid metabolism (CAM). Cactus pear produces both food and forage/fodder, a wide variety of high‐value byproducts, and serves as a bioenergy feedstock for biogas or bioethanol production. Here, we evaluated the biomass productivity of 14 Opuntia spp. accessions from the National Arid Land Plant Genetic Resources Unit (NALPGRU) in Parlier, CA under semi‐arid conditions with a planting density of 6667 plants ha−1 over a 3‐year period to identify high‐yielding biomass producers. Mean annual cladode fresh weight (CFW) (73.7 Mg ha−1 year−1), cladode dry weight (CDW) (5.2 Mg ha−1 year−1), and cladode count (CC) (10.5 cladodes plant−1) increased by 2.9‐, 2.8‐, and 2.8‐fold in year 3 compared with year 1. PARL 845, hybrid no. 46 (O. ficus‐indica × O. lindheimerii), showed the highest annual mean CFW (152.8 Mg ha−1 year−1), CDW (13.3 Mg ha−1 year−1), CC (22.1 cladodes plant−1), and dry matter content (DMC, 11.2%) among all accessions tested. Non‐hybrid accessions PARL 242 (O. cochenillifera), PARL 582 (Opuntia sp.), and PARL 584 (Opuntia sp.) showed 100% cladode establishment rates and CDW productivity of >6 Mg ha−1 year−1. Such biomass productivity results indicate that cactus pear displays great potential as a crop with many uses with lower water inputs than conventional crops for arid and semi‐arid environments.
Application of artificial intelligence techniques in meat processing: A review
Authors: Wang Mingyu , Li Xinxing 
Published: March 2024

AbstractThe field of meat processing plays a critical role in the food industry and has seen increasing adoption of artificial intelligence (AI) technology with rapid technological advancements. AI technology has tremendous potential for enhancing production efficiency and product quality in meat processing. However, further research and exploration are necessary to tackle the challenges posed by the use of AI technology. This article details the implementation of AI technology in meat processing, focusing on carcass classification, automation and intelligent processing, and meat‐quality detection. We aim to provide inspiration to researchers and industry professionals and promote the advancement of AI technology in the meat processing sector.Practical applicationsOur review article showcases the potential industrial applications of artificial intelligence (AI) techniques in the meat processing industry. AI technology can greatly improve production efficiency and product quality in meat processing. By implementing AI algorithms, meat processors can accurately classify carcasses, automate various processing tasks, and detect meat quality with higher accuracy. These advancements can lead to increased profitability and improved food safety in the industry. We hope to provide valuable insights for researchers and industry professionals, encouraging them to further explore and adopt AI technology in the meat processing sector.
A transcriptional cascade mediated by two APETALA2 family members orchestrates carotenoid biosynthesis in tomato
Authors: He Xiaoqing , Liu Kaidong , Wu Yi , Xu Weijie , Wang Ruochen , Pirrello Julien , Bouzayen Mondher , Wu Mengbo , Liu Mingchun 
Published: March 2024

ABSTRACTCarotenoids are important nutrients for human health that must be obtained from plants since they cannot be biosynthesized by the human body. Dissecting the regulatory mechanism of carotenoid metabolism in plants represents the first step toward manipulating carotenoid contents in plants by molecular design breeding. In this study, we determined that SlAP2c, an APETALA2 (AP2) family member, acts as a transcriptional repressor to regulate carotenoid biosynthesis in tomato (Solanum lycopersicum). Knockout of SlAP2c in both the “MicroTom” and “Ailsa Craig” backgrounds resulted in greater lycopene accumulation, whereas overexpression of this gene led to orange‐ripe fruit with significantly lower lycopene contents than the wild type. We established that SlAP2c represses the expression of genes involved in lycopene biosynthesis by directly binding to the cis‐elements in their promoters. Moreover, SlAP2c relies on its EAR motif to recruit the co‐repressors TOPLESS (TPL)2/4 and forms a complex with histone deacetylase (had)1/3, thereby reducing the histone acetylation levels of lycopene biosynthesis genes. Furthermore, SlAP2a, a homolog of SlAP2c, acts upstream of SlAP2c and alleviates the SlAP2c‐induced repression of lycopene biosynthesis genes by inhibiting SlAP2c transcription during fruit ripening. Therefore, we identified a transcriptional cascade mediated by AP2 family members that regulates lycopene biosynthesis during fruit ripening in tomato, laying the foundation for the manipulation of carotenoid metabolism in plants.
Where alcohol use disorder meets interoception: A meta‐analytic view on structural and functional neuroimaging data
Authors: Muehlhan Markus , Spindler Carolin , Nowaczynski Sandra , Buchner Claudius , Fascher Maximilian , Trautmann Sebastian 
Published: March 2024

AbstractAlcohol use disorder (AUD) has been associated with changes in the processing of internal body signals, known as interoception. Changes in brain structure, particularly in the insula, are thought to underlie impaired interoception. As studies specifically investigating this association are largely lacking, this analysis takes an approach that compares meta‐analytic results on interoception with recently published meta‐analytic results on gray matter reduction in AUD. A systematic literature search identified 25 eligible interoception studies. Activation likelihood estimation (ALE) was used to test for spatial convergence of study results. Overlap between interoception and AUD clusters was tested using conjunction analysis. Meta‐analytic connectivity modeling (MACM) and resting‐state functional connectivity were used to identify the functional network of interoception and to test where this network overlapped with AUD meta‐analytic clusters. The results were characterized using behavioral domain analysis. The interoception ALE identified a cluster in the left middle insula. There was no overlap with clusters of reduced gray matter in AUD. MACM analysis of the interoception cluster revealed a large network located in the insulae, thalami, basal nuclei, cingulate and medial frontal cortices, and pre‐ and postcentral gyri. Resting state analysis confirmed this result, showing the strongest connections to nodes of the salience‐ and somatomotor network. Five of the eight clusters that showed a structural reduction in AUD were located within these networks. The behavioral profiles of these clusters were suggestive of higher‐level processes such as salience control, somatomotor functions, and skin sensations. The results suggest an altered salience mapping of interoceptive signals in AUD, consistent with current models. Connections to the somatomotor network may be related to action control and integration of skin sensations. Mindfulness‐based interventions, pleasurable touch, and (deep) transcranial magnetic stimulation may be targeted interventions that reduce interoceptive deficits in AUD and thus contribute to drug use reduction and relapse prevention.image
Physical frailty trajectories in older stroke survivors: Findings from a national cohort study
Authors: Zeng Wen , Zhou Weijiao , Pu Junlan , Tong Beibei , Li Dan , Yao Yuanrong , Shang Shaomei 
Published: March 2024

AbstractBackgroundPhysical frailty (PF) is highly prevalent and associated with undesirable outcomes in stroke survivors aged 65 years or older. However, the long‐term trajectories of PF are understudied in those older stroke survivors.AimsTo identify PF trajectories and relative predictors associated with the PF trajectories in older stroke survivors.DesignThis is a secondary analysis of a population‐based cohort study in the United States.MethodsSix hundred and sixty‐three older stroke survivors from the National Health and Ageing Trends Study from 2015 to 2021 were included. PF was operationally assessed based on the Fried Frailty Phenotype. Trajectories were identified by group‐based trajectory modelling. The associations between sociodemographic characteristics, clinical factors, symptoms, cognitive factors and PF trajectories were examined using the design‐based logistic regression method.ResultsMost older stroke survivors were 75 and older (63.32%), female (53.99%), white (80.54%) and partnered (50.64%). Two PF trajectory groups were identified (Group 1: low risk, robust; 49.47%; Group 2: high risk, deteriorating; 50.53%). Individuals were at a higher risk to be assigned to Group 2 if they were 75–84 years (adjusted odds ratio [aOR]: 2.16, 95% CI: 1.23–3.80) or 85+ years (aOR: 2.77, 95% CI: 1.52–5.04), had fair self‐reported health (aOR: 2.78, 95% CI: 1.53–5.07) or poor self‐reported health (aOR: 3.37, 95% CI: 1.51–7.52), had comorbidities (aOR: 8.44, 95% CI: 1.31–54.42), had breathing problems (aOR: 2.18, 95% CI: 1.18–4.02) and had balance problems (aOR: 1.70, 95% CI: 1.06–2.73).ConclusionPF trajectories in older stroke survivors were heterogeneous and were associated with age, self‐rated health status, comorbidities, breathing problems and balance problems.Implication to Clinical PracticeEarly, routine, dynamic screening for stroke‐related physical frailty (PF) and relative predictors might be beneficial for identifying the most vulnerable individuals. Our findings might help develop strategies to manage PF progression.Reporting MethodThe reporting followed the STROBE guideline.
Treatment withdrawal experiences of women with breast cancer: A phenomenological study
Authors: Chi Shu‐Ching , Liu Yu‐Chen , konara mudiyanselage Sriyani Padmalatha , Fetzer Susan , Lin Mei‐Feng 
Published: March 2024

AbstractAimTo obtain an in‐depth understanding of the lived experiences, values, and beliefs of Taiwanese women with breast cancer who withdrew from cancer treatment.BackgroundFear of side effects, negative experiences and personal beliefs were identified as reasons for withdrawing from cancer treatments. Body–mind consciousness and body autonomy play a crucial role in cancer treatment decisions.DesignDescriptive phenomenological approach.MethodsWe conducted semi‐structured, face‐to‐face and in‐depth interviews with 16 women diagnosed with breast cancer. Participants were purposefully selected from the Cancer Registry database. Employing a phenomenological approach, our aim was to explore the lived experiences of these individuals. Data analysis followed Giorgi's five‐step process. To ensure a comprehensive report the COREQ checklist was applied.Findings‘The Determination to Preserve Me’ is the essence of treatment withdrawal, identified by three themes and seven sub‐themes. ‘Raising Body‐Mind Consciousness’ was generated using body autonomy and preventing repeated psychological trauma from the participant's view. Their lifestyles, maintaining the family role, and returning to a normal trajectory help develop ‘Maintaining Stability for Being a Patient and a Family Carer’. ‘Self‐Defending Against the Body Harm’ was generated by concerns about maintaining health and preventing harm.ConclusionWomen's behaviours became transformed by suffering. Actions were influenced by physical and psychological distress, misconceptions about treatments, and appearance changes by self‐determination through self‐protection.Relevance to clinical practiceHealthcare professionals should respect women's autonomy and work collaboratively to ensure their decision‐making with accurate information and awareness of the potential risks and benefits of treatment withdrawal need to concern.
Factors related to psychosocial adjustment in patients with enterostomy: Based on a national cross‐sectional survey
Authors: Zhou Lu , Zhang Zhengyang , Li Hui , Wang Ling 
Published: March 2024

AbstractAimsThis study aimed to explore the psychosocial adjustment of enterostomy patients on a national scale.DesignBased on a national cross‐sectional survey.MethodsFrom December 2021 and February 2023, a total of 22,040 enterostomy patients were assessed using the ostomy adjustment inventory‐20. Initial analysis involved employing the chi‐square test or Kruskal‐Wallis H test to identify factors influencing the psychosocial adjustment of these patients. Subsequently, multinomial logistic regression was used to determine the factors affecting the classification of psychosocial adjustment levels of enterostomy patients. The reporting of this study adhered to the STROBE checklist.ResultsEventually 21,124 patients with enterostomy were included in this study, out of which 7788 (36.9%) patients with low level of psychosocial adjustment, 11,803 (55.8%) patients with medium level of psychosocial adjustment and 1533 (7.3%) patients with high level of psychosocial adjustment. The factors influencing the classification of psychosocial adjustment levels of enterostomy patients were gender, educational background, carer, enterostomy self‐care knowledge score and medical payment method.ConclusionsThe overall psychosocial adjustment level of enterostomy patients is not optimistic, and the factors that may affect the classification of their psychosocial adjustment level are analysed. Individualised intervention should be given according to different psychosocial adjustment levels of enterostomy patients.Relevance to Clinical PracticeThe number of enterostomy patients with a high level of psychosocial adjustment is small in relation to the total number of enterostomy patients, and caregivers can provide health education to enterostomy patients by analysing the factors affecting the level of psychosocial adjustment of enterostomy patients.Patient or Public ContributionNone.
Trans family systems framework: Theorizing families' gender investments and divestments in cisnormativity
Authors: Robinson Brandon Andrew , Stone Amy L. 
Published: March 2024

AbstractObjectiveThis article calls on family scholars to take seriously how families are invested and divested in maintaining and reproducing cisnormativity.BackgroundFamilies can be a prime institution for the reproduction of cisnormativity. For transgender and nonbinary family members, families' investment in cisnormativity can generate ambiguous and toxic familial relations. Yet, family studies have not developed an adequate framework to examine how and why cisnormativity operates within families.MethodThe authors engage with empirical and theoretical work on gender, intersectionality, and families to examine how cisnormativity operates within family dynamics and processes. This article also focuses on work about trans people and families to capture how cisnormative processes within families affect trans people's familial relations.ResultsThe authors advance a trans family systems framework to show how families' cisgender investments and divestments shape familial processes. The concept of cisnormative compliance is introduced to capture the beliefs and practices of obedience established by family members for the purpose of reproducing cisnormativity. Family studies can move forward in studying these cisnormative processes through documenting how gender accountability shapes family dynamics, implementing new methods, furthering an intersectional analysis, and exploring complexities of space and place.ConclusionTo reimagine gender and families, family scholars need to study and foreground how cisnormativity shapes family dynamics and processes.
Focusing the critical race psychology lens: CRT and the psychological study of social issues
Authors: Salter Phia S. , Moadel‐Attie Roxanne , Miller Andrea L. , Brenick Alaina , Bonam Courtney M. 
Published: March 2024

AbstractThe years since George Floyd's murder in 2020 have been characterized by both a renewed attention to systemic racism and a backlash intended to silence conversations about race. Critical Race Theory (CRT), in particular, has become a larger part of the public discourse around race than ever before. Although CRT developed in the 1980s as a critical approach in legal studies and was incorporated into social psychology in the 1990s, psychology's engagement with CRT has been much more limited than that of other fields. In two installments, this special issue aims to (re)introduce psychological researchers to Critical Race Theory (CRT), to underscore CRT's importance and limitations in the context of psychological research, to feature novel applications and new directions in CRT, and to address the current political climate of opposition to discussions of CRT. The first installment looks inward to examine how psychology can more effectively advance racial equity within the field and the research we conduct by continuing to incorporate a CRT lens throughout higher education and research. The second installment looks outward to highlight psychological research that uses CRT frameworks to advance racial justice in society.