bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging
Authors: Mau Theresa , Blackwell Terri L , Cawthon Peggy M , Molina Anthony J A , Coen Paul M , Distefano Giovanna , Kramer Philip A , Ramos Sofhia V , Forman Daniel E , Goodpaster Bret H , Toledo Frederico G S , Duchowny Kate A , Sparks Lauren M , Newman Anne B , Kritchevsky Stephen B , Cummings Steven R 
Published: April 2024

Abstract

Background
The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity.

Methods
The Study of Muscle, Mobility and Aging (SOMMA) assessed ex vivo muscle mitochondrial energetics in 764 older adults (mean age = 76.4, 56.5% women, and 85.9% non-Hispanic White) by high-resolution respirometry of permeabilized muscle fibers. We estimated the proportional odds ratio (POR [95% CI]) for the likelihood of greater multimorbidity (4 levels: 0 conditions, N = 332; 1 condition, N = 299; 2 conditions, N = 98; or 3+ conditions, N = 35) from an index of 11 conditions, per SD decrement in muscle mitochondrial energetic parameters. Distribution of conditions allowed for testing the associations of maximal muscle energetics with some individual conditions.

Results
Lower oxidative phosphorylation supported by fatty acids and/or complex I- and II-linked carbohydrates (eg, Max OXPHOSCI+CII) was associated with a greater multimorbidity index score (POR = 1.32 [1.13, 1.54]) and separately with diabetes mellitus (OR = 1.62 [1.26, 2.09]), depressive symptoms (OR = 1.45 [1.04, 2.00]) and possibly chronic kidney disease (OR = 1.57 [0.98, 2.52]) but not significantly with other conditions (eg, cardiac arrhythmia, chronic obstructive pulmonary disease).

Conclusions
Lower muscle mitochondrial bioenergetic capacities were associated with a worse composite multimorbidity index score. Our results suggest that decrements in muscle mitochondrial energetics may contribute to a greater global burden of disease and are more strongly related to some conditions than others.
Male rape: survivors, support and the law in late twentieth-century England and Wales
Authors: Severs George J 
Published: April 2024

Abstract
Until 1994, men were not recognized legally as victims of rape in England and Wales. This article explores the history of male survivors of rape there, establishing the uneven patchwork of support services available to them prior to 1994. It argues that a growing psychiatric literature which studied male survivors of sexual violence was a major factor in convincing lawmakers to include men as potential victims of rape in updated sexual offence legislation. Other medical professionals played key roles in bringing male survivors to police attention, but psychiatric research was most influential in changing the policy agenda in this arena.
Policing the Enforcers: The Governmentality of Immigration Controls
Authors: Consterdine Erica 
Published: April 2024

Abstract
As border controls have spanned from the territorial border to the interior, outsourcing controls to non-state actors has become the integral technology in everyday bordering. Whilst the racialized consequences of deputizing controls have been illuminated, the governmentality and biopolitical implications of these outsourcing processes have been overlooked. This paper argues that as the architecture of migration controls has evolved, the targets of control have widened; that migration controls have transcended migrants and are also used as a way to control sovereign subjects. Taking the genealogy of UK immigration control policy as a case study, the paper shows how the processes of outsourcing immigration controls to corporations, public institutions, and the private sphere have inverted the target of control through a governmentality of coercive measures and incentive structures. I argue that in outsourcing controls to non-state actors, the taken-for-granted boundaries between who is subject to immigration control and who is not are blurred because as sovereign subjects become complicit in borderwork, they also become subject to state violence. The implication is that all subjects become subject to immigration control, provoking the question of who immigration controls serve and to what end.
The Pandemic Response Commons
Authors: Trunnell Matthew , Frankenberger Casey , Hota Bala , Hughes Troy , Martinov Plamen , Ravichandran Urmila , Shah Nirav S , Grossman Robert L ,   Pandemic Response Commons Consortium, Frankenberger Casey A , Grossman Robert L , Hota Bala , Hughes Troy , Kuffel Gina R , Martinov Plamen , Ribeyre Pauline , Savatore Lea , Shah Nirav , Swirsky Eric S , Trunnell Matthew , Krive Jacob , Holper Tim , Roesch Pamela T , Shah Nirav , Simmons J Alan , Swirsky Eric , Schumm L Philip , Locey Kenneth J , Grossman Robert L , Zhang Zhenyu , Giurcanu Mihai , McKinney Suzet , Willding Stephanie D , Jay Kim , Roesch Pamela T , Swirsky Eric , Salvatore Lea , Grossman Robert L , Hoffman Michelle B , Gagnon Keith T , Sinha Koushik , Trunnell Matthew 
Published: April 2024

AbstractObjectivesA data commons is a software platform for managing, curating, analyzing, and sharing data with a community. The Pandemic Response Commons (PRC) is a data commons designed to provide a data platform for researchers studying an epidemic or pandemic.MethodsThe PRC was developed using the open source Gen3 data platform and is based upon consortium, data, and platform agreements developed by the not-for-profit Open Commons Consortium. A formal consortium of Chicagoland area organizations was formed to develop and operate the PRC.ResultsThe consortium developed a general PRC and an instance of it for the Chicagoland region called the Chicagoland COVID-19 Commons. A Gen3 data platform was set up and operated with policies, procedures, and controls for a NIST SP 800-53 revision 4 Moderate system. A consensus data model for the commons was developed, and a variety of datasets were curated, harmonized and ingested, including statistical summary data about COVID cases, patient level clinical data, and SARS-CoV-2 viral variant data.Discussion and conclusionsGiven the various legal and data agreements required to operate a data commons, a PRC is designed to be in place and operating at a low level prior to the occurrence of an epidemic, with the activities increasing as required during an epidemic. A regional instance of a PRC can also be part of a broader data ecosystem or data mesh consisting of multiple regional commons supporting pandemic response through sharing regional data.
Annual and lunar-cycle-related breeding rhythmicity in the acorn barnacle Tetraclita kuroshioensis Chan, Tsang & Chu, 2007 (Cirripedia: Balanomorpha: Tetraclitidae) in Okinawa, Japan
Authors: Katayama Aoi , Tan Ee Suan , Takekata Hiroki , Takemura Akihiro 
Published: April 2024

Abstract
We investigated the reproduction of the barnacle Tetraclita kuroshioensisChan, Tsang & Chu, 2007 (Cirripedia: Thoracica: Tetraclitidae) at different heights in the intertidal zone in Okinawa, Japan with a focus on gonadal development, the brooding of eggs, and unhatched larvae, as well as the role of environmental factors in breeding rhythmicity. Histological observations collected around each full moon from September 2019 to October 2020 showed various stages of oocyte development in September and October 2019 and from March to September 2020, whereas mature testes were observed from April to October 2020. The breeding season of this species thus lasts for at least seven months under long-day conditions at a water temperature above 21 °C. Barnacles collected from three tidal levels on multiple occasions during April, August, and October 2020 displayed little vertical variation in their stage of ovarian development, but there was a noticeable difference in the percentage of brooding individuals in August and October, as well as an increased prevalence of brooding during the new-moon phase at the upper and middle tidal heights. Our findings indicate that larval release by T. kuroshioensis undergoes seasonal variation, apparently influenced by the cycles of lunar (major factor) and tide (minor factor) in their habitat.
Türkiye’s nuclear energy aspirations: policy challenges and legal trajectory
Authors: Artantas Onur Cagdas 
Published: April 2024

Abstract
This article provides a comprehensive overview of Türkiye’s nuclear energy aspirations, focusing on the historical evolution, international cooperation, organizational structure, legal framework, and policy dimensions. It elaborates on Türkiye’s endeavours to integrate nuclear energy into its national power infrastructure, particularly highlighting the progress made in the development of the Akkuyu Nuclear Power Plant (NPP). Initiated in 1968, the Akkuyu NPP project remained stagnant for decades. It gained momentum in the late 2010s when Rosatom, under an agreement between the Turkish and Russian states, began construction as part of its nuclear export strategy. The article mainly discusses the significant legislative and regulatory advancements made post-2021, propelled by the near completion of the Akkuyu NPP. These actions signify a crucial phase in creating a robust legal framework for nuclear energy in Türkiye. Moreover, the article presents proposals for law and policy, considering geopolitical, economic, and technical constraints, to guide the future direction of Türkiye’s domestic nuclear energy programme. In conclusion, the evolution of nuclear energy law in Türkiye, highlighted by the development of the Akkuyu NPP and subsequent legal and regulatory measures, presents an essential case study.
Bridging the organoid translational gap: integrating standardization and micropatterning for drug screening in clinical and pharmaceutical medicine
Authors: Yang Haowei , Li Jiawei , Wang Zitian , Khutsishvili Davit , Tang Jiyuan , Zhu Yu , Cai Yongde , Dai Xiaoyong , Ma Shaohua 
Published: April 2024

Abstract
Synthetic organ models such as organoids and organ-on-a-chip have been receiving recognition from administrative agencies. Despite the proven success of organoids in predicting drug efficacy on laboratory scales, their translational advances have not fully satisfied the expectations for both clinical implementation and commercial applications. The transition from laboratory settings to clinical applications continues to encounter challenges. Employing engineering methodologies to facilitate the bridging of this gap for organoids represents one of the key directions for future advancement. The main measures to bridge the gap include environmental and phenotypic recapitulation, 3D patterning, matrix engineering, and multi-modality information acquisition and processing. Pilot whole-process clinical/pharmaceutical applications with fast and standardized organoid models will continuously offer convincing frontline optimization clues and driving forces to the organoid community, which is a promising path to translational organoid technologies.
Bi-Gaussianized calibration of likelihood ratios
Authors: Morrison Geoffrey Stewart 
Published: April 2024

Abstract
For a perfectly calibrated forensic evaluation system, the likelihood ratio of the likelihood ratio is the likelihood ratio. Conversion of uncalibrated log-likelihood ratios (scores) to calibrated log-likelihood ratios is often performed using logistic regression. The results, however, may be far from perfectly calibrated. We propose and demonstrate a new calibration method, “bi-Gaussianized calibration,” that warps scores toward perfectly calibrated log-likelihood-ratio distributions. Using both synthetic and real data, we demonstrate that bi-Gaussianized calibration leads to better calibration than does logistic regression, that it is robust to score distributions that violate the assumption of two Gaussians with the same variance, and that it is competitive with logistic-regression calibration in terms of performance measured using log-likelihood-ratio cost (Cllr). We also demonstrate advantages of bi-Gaussianized calibration over calibration using pool-adjacent violators (PAV). Based on bi-Gaussianized calibration, we also propose a graphical representation that may help explain the meaning of likelihood ratios to triers of fact.
Probing dark matter with adaptive-optics based flux ratio anomalies: photometric and astrometric precision
Authors: Zelko Ioana A , Nierenberg Anna M , Treu Tommaso 
Published: April 2024

ABSTRACT
Strong gravitational lensing is a powerful probe of the distribution of matter on sub-kpc scales. It can be used to test the existence of completely dark sub-haloes surrounding galaxies, as predicted by the standard cold dark matter model, or to test alternative dark matter models. The constraining power of the method depends strongly on photometric and astrometric precision and accuracy. We simulate and quantify the capabilities of upcoming adaptive optics systems and advanced instruments on ground-based telescopes, focusing as an illustration on the Keck Telescope (OSIRIS + KAPA, LIGER + KAPA) and the Thirty Meter Telescope (TMT; IRIS + NFIRAOS). We show that these new systems will achieve dramatic improvements over current ones in both photometric and astrometric precision. Narrow line flux ratio errors below 2 per cent, and submilliarcsecond astrometric precision will be attainable for typical quadruply imaged quasars. With TMT, the exposure times required will be of order a few minutes per system, enabling the follow-up of 100–1000 systems expected to be discovered by the Rubin, Euclid, and Roman Telescopes.
The chemistry and excitation of H2 and HD in the early Universe
Authors: Faure A , Hily-Blant P , Pineau des Forêts G , Flower D R 
Published: April 2024

ABSTRACT
We have critically reviewed the literature pertaining to reactions that are significant for the chemistry of hydrogen-, deuterium-, and helium-bearing species in the homogeneous early Universe. For each reaction rate coefficient, we provide a fit in the modified-Arrhenius form, specifying the corresponding uncertainty and temperature range. This new network, limited to 21 reactions, should be the most reliable to date. Combined with accurate state-to-state rate coefficients for inelastic and reactive collisions involving H2 and HD, it allows us for the first time to follow the evolution of the abundances of atomic and molecular species, level populations of H2 and HD, and the ortho:para ratio (OPR) of H2, in a self-consistent fashion during the adiabatic expansion of the universe. The abundances of H2 and HD change only marginally compared to previous models, indicating that the uncertainties on the main reaction rate coefficients have essentially been removed. We also find that the adiabatic expansion has a dramatic effect on the OPR of H2, which freezes-out at redshifts z ≲ 50. In contrast, at higher redshifts, the populations of the rotational levels of H2 and HD are predicted to be fully thermalized at the temperature of the cosmic background radiation field, a result that conflicts with some recent, independent calculations. This new network allows the chemistry of primordial gas to be followed during the early phase of collapse towards Population III star progenitors.
Constraints on atmospheric water abundance and cloud deck pressure in the warm Neptune GJ 3470 b via CARMENES transmission spectroscopy
Authors: Dash Spandan , Brogi Matteo , Gandhi Siddharth , Lafarga Marina , Meech Annabella , Bello-Arufe Aaron , Wheatley Peter J 
Published: April 2024

ABSTRACT
Observations of cooler atmospheres of super-Earths and Neptune sized objects often show flat transmission spectra. The most likely cause of this trend is the presence of aerosols (i.e. clouds and hazes) in the atmospheres of such objects. High-resolution spectroscopy provides an opportunity to test this hypothesis by targeting molecular species whose spectral line cores extend above the level of such opaque decks. In this work, we analyse high-resolution infrared observations of the warm Neptune GJ 3470 b taken over two transits using CARMENES (R ∼ 80 000) and look for signatures of H2O (previously detected using Hubble Space Telescope (HST) WFC3 + Spitzer observations) in these transits with a custom pipeline fully accounting for the effects of data cleaning on any potential exoplanet signal. We find that our data are potentially able to weakly detect (∼3σ) an injected signal equivalent to the best-fitting model from previous HST WFC3 + Spitzer observations. However, we do not make a significant detection using the actual observations. Using a Bayesian framework to simultaneously constrain the H2O volume mixing ratio (VMR) and the cloud top pressure level, we select a family of models compatible with the non-detection. These are either very high VMR cloud-free models, solar-abundance models with a high cloud deck, or sub-solar abundance models with a moderate cloud deck. This is a broader range compared to published results from low-resolution spectroscopy, but is also compatible with them at a 1σ level.
Impact of property covariance on cluster weak lensing scaling relations
Authors: Zhang Zhuowen , Farahi Arya , Nagai Daisuke , Lau Erwin T , Frieman Joshua , Ricci Marina , von der Linden Anja , Wu Hao-Yi ,   LSST Dark Energy Science Collaboration, von der Linden Anja , Varga Tamas , Wu Hao-Yi , Hearin Andrew , Kelly Heather , Esteves Johnny , Xhakaj Enia , Zhou Conghao 
Published: April 2024

ABSTRACT
We present an investigation into a hitherto unexplored systematic that affects the accuracy of galaxy cluster mass estimates with weak gravitational lensing. Specifically, we study the covariance between the weak lensing signal, ΔΣ, and the ‘true’ cluster galaxy number count, Ngal, as measured within a spherical volume that is void of projection effects. By quantifying the impact of this covariance on mass calibration, this work reveals a significant source of systematic uncertainty. Using the MDPL2 simulation with galaxies traced by the SAGE semi-analytic model, we measure the intrinsic property covariance between these observables within the three-dimensional vicinity of the cluster, spanning a range of dynamical mass and redshift values relevant for optical cluster surveys. Our results reveal a negative covariance at small radial scales (R ≲ R200c) and a null covariance at large scales (R ≳ R200c) across most mass and redshift bins. We also find that this covariance results in a $2{\!-\!}3~{{\ \rm per\ cent}}$ bias in the halo mass estimates in most bins. Furthermore, by modelling Ngal and ΔΣ as multi-(log)-linear equations of secondary halo properties, we provide a quantitative explanation for the physical origin of the negative covariance at small scales. Specifically, we demonstrate that the Ngal–ΔΣ covariance can be explained by the secondary properties of haloes that probe their formation history. We attribute the difference between our results and the positive bias seen in other works with (mock)-cluster finders to projection effects. These findings highlight the importance of accounting for the covariance between observables in cluster mass estimation, which is crucial for obtaining accurate constraints on cosmological parameters.
Number of Influenza Risk Factors Informs an Adult's Increased Potential of Severe Influenza Outcomes: A Multiseason Cohort Study From 2015 to 2020
Authors: McGovern Ian , Cappell Katherine , Bogdanov Alina N , Haag Mendel D M 
Published: April 2024

Abstract

Background
While studies have evaluated factors influencing the risk of severe influenza outcomes, there is limited evidence on the additive impact of having multiple influenza risk factors and how this varies by age.

Methods
Patients ≥18 years of age in the United States were evaluated retrospectively in 5 seasonal cohorts during the 2015–2020 influenza seasons. Patient-level electronic medical records linked to pharmacy and medical claims were used to ascertain covariates and outcomes. Multivariable logistic regression models were fitted for the overall population and by age subgroups to evaluate the association of demographic and clinical characteristics with odds of influenza-related medical encounters (ICD-10 codes J09*–J11*). The logistic regression models included sex, race/ethnicity, geographic region, baseline health care resource use, vaccination status, specific high-risk comorbidities, number of influenza risk factors, body mass index, and smoking status. Odds ratios from each of the 5 seasons were summarized via fixed effect meta-analysis.

Results
Season cohort sizes ranged from 887 260 to 3 628 168 adults. Of all patient characteristics evaluated, an individual’s cumulative number of high-risk influenza conditions, as defined per the Centers for Disease Control and Prevention, was the most predictive of an increased probability of having an influenza-related medical encounter overall and across age groups. For adults of any age, odds ratios for influenza hospitalization ranged from 1.8 (95% CI, 1.7–2.0) for 1 risk factor to 6.4 (95% CI, 5.8–7.0) for ≥4 risk factors.

Conclusions
These results show that a simple measure such as the number of influenza risk factors can be highly informative of an adult's potential for severe influenza outcomes.
Risk Factors for and Outcomes Following Early Acquisition ofMycobacterium abscessusComplex After Lung Transplantation
Authors: Nick Sophie E , Yarrington Michael E , Reynolds John M , Anderson Deverick J , Baker Arthur W 
Published: April 2024

AbstractBackgroundLung transplant recipients are at increased risk of Mycobacterium abscessus complex (MABC) acquisition and invasive infection. We analyzed risk factors and outcomes of early post–lung transplant MABC acquisition.MethodsWe conducted a retrospective matched case–control study of patients who underwent lung transplant from 1/1/2012 to 12/31/2021 at a single large tertiary care facility. Cases had de novo MABC isolation within 90 days post-transplant. Controls had no positive MABC cultures and were matched 3:1 with cases based on age and transplant date. Recipient demographics and pre-/peri-operative characteristics were analyzed, and a regression model was used to determine independent risk factors for MABC acquisition. We also assessed 1-year post-transplant outcomes, including mortality.ResultsAmong 1145 lung transplants, we identified 79 cases and 237 matched controls. Post-transplant mechanical ventilation for &gt;48 hours was independently associated with MABC acquisition (adjusted odds ratio, 2.46; 95% CI, 1.29–4.72; P = .007). Compared with controls, cases required more days of hospitalization after the MABC index date (28 vs 12 days; P = .01) and had decreased 1-year post-transplant survival (78% vs 89%; log-rank P = .02). One-year mortality appeared highest for cases who acquired M. abscessus subsp. abscessus (31% mortality) or had extrapulmonary infections (43% mortality).ConclusionsIn this large case–control study, prolonged post-transplant ventilator duration was associated with early post–lung transplant MABC acquisition, which in turn was associated with increased hospital-days and mortality. Further studies are needed to determine the best strategies for MABC prevention, surveillance, and management.