bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective treatment of Clostridioides difficile infection improves survival and affects graft-versus-host disease: a multicenter study by the Polish Adult Leukemia Group
Authors: Piekarska Agnieszka , Sadowska-Klasa Alicja , Mensah-Glanowska Patrycja , Sobczyk-Kruszelnicka Małgorzata , Drozd-Sokołowska Joanna , Waszczuk-Gajda Anna , Kujawska Joanna , Wilk Mateusz , Tomaszewska Agnieszka , Zaucha Jan M. , Giebel Sebastian , Gil Lidia 
Published: March 2024

AbstractClostridioides difficile infection (CDI) is the most common cause of infectious diarrhea after allogeneic hematopoietic cell transplantation (allo-HCT). The impact of CDI and its treatment on allo-HCT outcomes and graft-versus-host disease (GVHD), including gastrointestinal GVHD (GI-GVHD) is not well established. This multicenter study assessed real-life data on the first-line treatment of CDI and its impact on allo-HCT outcomes. Retrospective and prospective data of patients with CDI after allo-HCT were assessed. We noted statistically significant increase in the incidence of acute GVHD and acute GI-GVHD after CDI (P = 0.005 and P = 0.016, respectively). The first-line treatment for CDI included metronidazole in 34 patients, vancomycin in 64, and combination therapy in 10. Treatment failure was more common with metronidazole than vancomycin (38.2% vs. 6.2%; P < 0.001). The need to administer second-line treatment was associated with the occurrence or exacerbation of GVHD (P < 0.05) and GI-GVHD (P < 0.001) and reduced overall survival (P < 0.05). In the multivariate analysis, the risk of death was associated with acute GVHD presence before CDI (hazard ratio [HR], 3.19; P = 0.009) and the need to switch to second-line treatment (HR, 4.83; P < 0.001). The efficacy of the initial CDI treatment affects survival and occurrence of immune-mediated GI-GVHD after allo-HCT. Therefore, agents with higher efficacy than metronidazole (vancomycin or fidaxomicin) should be administered as the first-line treatment.
Ground reaction forces better than center of pressure differentiate postural control between young female volleyball players and untrained peers
Authors: Borzucka Dorota , Kręcisz Krzysztof , Kuczyński Michał 
Published: March 2024

AbstractA comprehensive explanation of the relationship between postural control and athletic performance requires compare body balance in athletes with their never training counterparts. To fill this gap in relation to volleyball, the aim of this study was to compare the balance of intermediate adolescent female players (VOL, n = 61) with inactive peers (CON, n = 57). The participants were investigated in normal quiet stance during 20 s trials on a Kistler force plate. The traditional spatial (amplitude and mean speed) and temporal (frequency and entropy) indices were computed for ground reaction forces (GRF) and center-of-pressure (COP) time-series. The spatial parameters of the both time-series did not discriminate the two groups. However, the temporal GRF parameters revealed much lower values in VOL than in CON (p < .0001). This leads to three important conclusions regarding posturography applications. First, GRF and COP provide different information regarding postural control. Second, measures based on GRF are more sensitive to changes in balance related to volleyball training and perhaps to similar training and sports activity regimens. And third, the indicators calculated based on these two time series can complement each other and thus enrich the insight into the relationship between balance and sports performance level.
Effects of adaptation measures to extreme heat throughout medium and high temperature periods, case study at the Osaka expo site
Authors: Takebayashi Hideki , Maeda Nao 
Published: March 2024

AbstractFor the Osaka-Kansai Expo, to be held from April to October 2025, it is necessary to manage the exhibition site with consideration for countermeasures against heat in order to make safe and active use of the outdoor space. In this study, we compared meteorological data observed at Expo site on the sea coast, and at the Osaka Meteorological Observatory in the city center to analyze the quantitative relationship between meteorological elements at both locations, calculated thermal environment indices using these meteorological data, and considered the effects of implementing adaptation measures against the heat. The effect of solar radiation shading is predominant in lowering SET* and WBGT. During the medium temperature period, before mid-June and after mid-September, solar radiation shading avoids uncomfortable conditions, and during the high temperature period, from late June to mid-July and mid-August to early September, solar radiation shading, surface cover improvement, and mist spraying reduce the risk of heat stroke. However, during the extremely hot period, from late July to early August, the risk of heat stroke cannot be avoided by any of the adaptation measures to heat.
Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species
Authors: Azadi Sedigheh , Azizipour Esmat , Amani Ali Mohammad , Vaez Ahmad , Zareshahrabadi Zahra , Abbaspour Alireza , Firuzyar Tahereh , Dortaj Hengameh , Kamyab Hesam , Chelliapan Shreeshivadasan , Mosleh-Shirazi Sareh 
Published: March 2024

AbstractThe antifungal efficacy and cytotoxicity of a novel nano-antifungal agent, the Fe3O4@SiO2/Schiff-base complex of Cu(II) magnetic nanoparticles (MNPs), have been assessed for targeting drug-resistant Candida species. Due to the rising issue of fungal infections, especially candidiasis, and resistance to traditional antifungals, there is an urgent need for new therapeutic strategies. Utilizing Schiff-base ligands known for their broad-spectrum antimicrobial activity, the Fe3O4@SiO2/Schiff-base/Cu(II) MNPs have been synthesized. The Fe3O4@SiO2/Schiff-base/Cu(II) MNPs was characterized by Fourier Transform-Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), Energy-dispersive X-ray (EDX), Vibrating Sample Magnetometer (VSM), and Thermogravimetric analysis (TGA), demonstrating successful synthesis. The antifungal potential was evaluated against six Candida species (C. dubliniensis, C. krusei, C. tropicalis, C. parapsilosis, C. glabrata, and C. albicans) using the broth microdilution method. The results indicated strong antifungal activity in the range of 8–64 μg/mL with the lowest MIC (8 μg/mL) observed against C. parapsilosis. The result showed the MIC of 32 μg/mL against C. albicans as the most common infection source. The antifungal mechanism is likely due to the disruption of the fungal cell wall and membrane, along with increased reactive oxygen species (ROS) generation leading to cell death. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay for cytotoxicity on mouse L929 fibroblastic cells suggested low toxicity and even enhanced cell proliferation at certain concentrations. This study demonstrates the promise of Fe3O4@SiO2/Schiff-base/Cu(II) MNPs as a potent antifungal agent with potential applications in the treatment of life-threatening fungal infections, healthcare-associated infections, and beyond.
Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury
Authors: Tamai Koji , Terai Hidetomi , Nakamura Hiroaki , Yokogawa Noriaki , Sasagawa Takeshi , Nakashima Hiroaki , Segi Naoki , Ito Sadayuki , Funayama Toru , Eto Fumihiko , Yamaji Akihiro , Watanabe Kota , Yamane Junichi , Takeda Kazuki , Furuya Takeo , Yunde Atsushi , Nakajima Hideaki , Yamada Tomohiro , Hasegawa Tomohiko , Terashima Yoshinori , Hirota Ryosuke , Suzuki Hidenori , Imajo Yasuaki , Ikegami Shota , Uehara Masashi , Tonomura Hitoshi , Sakata Munehiro , Hashimoto Ko , Onoda Yoshito , Kawaguchi Kenichi , Haruta Yohei , Suzuki Nobuyuki , Kato Kenji , Uei Hiroshi , Sawada Hirokatsu , Nakanishi Kazuo , Misaki Kosuke , Kuroda Akiyoshi , Inoue Gen , Kakutani Kenichiro , Kakiuchi Yuji , Kiyasu Katsuhito , Tominaga Hiroyuki , Tokumoto Hiroto , Iizuka Yoichi , Takasawa Eiji , Akeda Koji , Takegami Norihiko , Funao Haruki , Oshima Yasushi , Kaito Takashi , Sakai Daisuke , Yoshii Toshitaka , Ohba Tetsuro , Otsuki Bungo , Seki Shoji , Miyazaki Masashi , Ishihara Masayuki , Okada Seiji , Imagama Shiro , Kato Satoshi 
Published: March 2024

AbstractThis retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan–Meier analysis, the median survival times were 44.9 and 76.5 months for patients with major nutrition-related risk and matched controls, respectively (p = 0.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale ≥ 1 grade (p = 0.039) and independence in ADL at 1 year post-injury than patients with major nutrition-related risk (p < 0.05). In conclusion, 6% of older patients with cervical SCI had major nutrition-related risks; they showed a significantly higher 1 year mortality rate, shorter survival time, poorer neurological improvement, and lower ADL at 1 year post-injury than matched controls.
Cross-cultural perception of strength, attractiveness, aggressiveness and helpfulness of Maasai male faces calibrated to handgrip strength
Authors: Butovskaya Marina L. , Rostovstseva Victoria V. , Mezentseva Anna A. , Kavina Alexander , Rizwan Muhammad , Shi Yuanyuan , Vilimek Vítězslav , Davletshin Albert 
Published: March 2024

AbstractPrevious research has demonstrated that Maasai and Europeans tend to align in their ratings of the physical strength and aggressiveness of Maasai male faces, calibrated to hand grip strength (HGS). However, perceptions of attractiveness of these faces differed among populations. In this study, three morphs of young Maasai men created by means of geometric morphometrics, and depicting the average sample and two extrema (± 4 SD of HGS), were assessed by men and women from Tanzania, Czech Republic, Russia, Pakistan, China, and Mexico (total sample = 1540). The aim of this study was to test cross-cultural differences in the perception of young Maasai men’s composites calibrated to HGS, focusing on four traits: physical strength, attractiveness, aggressiveness, and helpfulness. Individuals from all six cultures were able to distinguish between low, medium, and high HGS portraits. Across all study populations, portrait of Maasai men with lower HGS was perceived as less attractive, more aggressive, and less helpful. This suggests that people from diverse populations share similar perceptions of physical strength based on facial shape, as well as attribute similar social qualities like aggressiveness and helpfulness to these facial images. Participants from all samples rated the composite image of weak Maasai men as the least attractive.
Longitudinal association of oral functions and dementia in Japanese older adults
Authors: Iwai Komei , Azuma Tetsuji , Yonenaga Takatoshi , Sasai Yasuyuki , Nomura Taketsugu , Sugiura Iwane , Inagawa Yujo , Matsumoto Yusuke , Nakashima Seiji , Abe Yoshikazu , Tomofuji Takaaki 
Published: March 2024

AbstractThe relationship between oral functions and dementia was examined in 7384 older adults (age ≥ 75 years) who visited a dental clinic in Gifu, Japan. Participants without dementia in a baseline survey in April 2018 were followed until March 2021. As oral functions, chewing function, tongue and lip function, and swallowing function were assessed by self-administered questionnaire, by oral diadochokinesis test, and by repetitive saliva swallowing test, respectively. The presence of systemic diseases was based on data obtained from the National Database of Health Insurance of Japan. At follow-up, 415 (6%) participants were diagnosed with dementia. Multivariate logistic regression analyses showed the presence of dementia at follow-up was associated with female (odds ratio [OR] 1.386; 95% confidence interval [CI] 1.117–1.719), age (OR 1.078; CI 1.056–1.101), regular dental checkups (absence; OR 1.452; CI 1.180–1.788), brushing frequency ≥ twice/day (absence; OR 1.510; CI 1.194–1.911), decayed teeth (presence; OR 1.328; CI 1.071–1.648), swallowing function (poor; OR 1.484; CI 1.135–1.939) at baseline. It was found that poor swallowing function was associated with the future onset of dementia.
The relationship between earthquake risk perceptions, religious orientation, spiritual well-being in individuals with and without earthquake experience: a cross-sectional study
Authors: Gökçay Gönül , Çevirme Ayşe , İncirkuş Küçük Hülya , Genç Akgün Zeynep 
Published: March 2024

AbstractThe physical and psychological effects of earthquakes on individuals with their experience dimension are important. This study aimed to examine the relationship between earthquake risk perception, religious orientation, and spiritual well-being among individuals with and without earthquake experience. The data collection instruments included a socio-demographic information questionnaire, earthquake risk perception scale, religious orientation scale, and three-factor spiritual well-being scale. Statistical evaluations were performed using independent samples t test, one-way ANOVA test, Mann–Whitney U test, Kruskal–Wallis test (Levene), Pearson correlation, and multiple linear regression analyses. About 59.9% of the participants had experienced an earthquake. Individuals with earthquake experience scored 33.04 ± 7.80 on the earthquake risk perception scale, 100.65 ± 20.80 on the religious orientation scale, and 119.66 ± 18.87 on the three-factor spiritual well-being scale. Those without earthquake experience scored 31.57 ± 7.74, 96.70 ± 18.46, and 114.09 ± 18.04 on the respective scales. The average scores on the earthquake risk perception scale were found to be statistically significant with respect to gender, while the average scores on the religious orientation scale and the three-factor spiritual well-being scale were found to be statistically significant with respect to both gender and substance use. The regression analysis revealed that religious orientation and three-factor spiritual well-being significantly predicted 13.5% of the variance in earthquake risk perception. Studies to increase individuals’ risk perception are important in minimizing the destructive effects of earthquakes in countries in the earthquake zone.
Objective sleep quality predicts subjective sleep ratings
Authors: Pierson-Bartel Róbert , Ujma Péter Przemyslaw 
Published: March 2024

AbstractIn both clinical and observational studies, sleep quality is usually assessed by subjective self-report. The literature is mixed about how accurately these self-reports track objectively (e.g. via polysomnography) assessed sleep quality, with frequent reports of little to no association. However, previous research on this question focused on between-subject designs, which may be confounded by trait-level variables. In the current study, we used the novel Budapest Sleep, Experiences and Traits Study (BSETS) dataset to investigate if within-subject differences in subjectively reported sleep quality are related to sleep macrostructure and quantitative EEG variables assessed using a mobile EEG headband. We found clear evidence that self-reported sleep quality in the morning is influenced by within-subject variations in sleep onset latency, wake after sleep onset, total sleep time, and sleep efficiency. These effects were replicated if detailed sleep composition metrics (percentage and latency of specific vigilance states) or two alternative measures of subjective sleep quality were used instead. We found no effect of the number of awakenings or relative EEG delta and sigma power. Between-subject effects (relationships between individual mean values of sleep metrics and subjective sleep quality) were also found, highlighting that analyses focusing only on these may be erroneous. Our findings show that while previous investigations of this issue may have been confounded by between-subject effects, objective sleep quality is indeed reflected in subjective sleep ratings.
The molecular sociology of NHERF1 PDZ proteins controlling renal hormone-regulated phosphate transport
Authors: Friedman Peter A. , Mamonova Tatyana 
Published: March 2024

Abstract
Parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) control extracellular phosphate levels by regulating renal NPT2A-mediated phosphate transport by a process requiring the PDZ scaffold protein NHERF1. NHERF1 possesses two PDZ domains, PDZ1 and PDZ2, with identical core-binding GYGF motifs explicitly recognizing distinct binding partners that play different and specific roles in hormone-regulated phosphate transport. The interaction of PDZ1 and the carboxy-terminal PDZ-binding motif of NPT2A (C-TRL) is required for basal phosphate transport. PDZ2 is a regulatory domain that scaffolds multiple biological targets, including kinases and phosphatases involved in FGF23 and PTH signaling. FGF23 and PTH trigger disassembly of the NHERF1–NPT2A complex through reversible hormone-stimulated phosphorylation with ensuing NPT2A sequestration, down-regulation, and cessation of phosphate absorption. In the absence of NHERF1–NPT2A interaction, inhibition of FGF23 or PTH signaling results in disordered phosphate homeostasis and phosphate wasting. Additional studies are crucial to elucidate how NHERF1 spatiotemporally coordinates cellular partners to regulate extracellular phosphate levels.
Pediatric Hearing Aid Daily Wear Time Is Significantly Impacted by Clinician–Family Language Discordance
Authors: Brigham Nicole , Thompson Emily C. , Picou Erin M. , Davis Hilary , Tharpe Anne Marie 
Published: March 2024

Purpose:
The purpose of this study was to evaluate the potential contribution of limited English proficiency on daily hearing aid wear time for children with hearing loss.

Method:
A retrospective chart review was completed to evaluate hearing aid wear time based on data logging information available at the time of a follow-up visit following an initial hearing aid fitting. Children were included in the study if they had permanent bilateral hearing loss and were less than 60 months of age at the time of their first follow-up visit. Wear time was compared between children who attended an interpreter-mediated appointment and those who did not have an interpreter present. The presence of an interpreter at the appointment was the study indicator that the family had limited English proficiency.

Results:

Children from families with limited English proficiency exhibited significantly shorter daily wear time (
M
= 1.3 hr) than their peers whose families were English-proficient speakers, thus, having a shared language with their audiologists (
M
= 5.2 hr).

Conclusions:
Results of this study suggest that family–clinician language discordance might put children at greater risk of shorter hearing aid wear time than children whose caregivers share a common language with their child's audiologist. There can be many linguistic, cultural, and educational factors that contribute to hearing aid wear time in children whose families have limited English proficiency as well as different approaches to improving that wear time. Efforts should ensure that hearing and hearing aid–related information is accessible to all families, especially those with clinician–family language discordance. Such efforts can include, among others, training that improves clinicians' cultural and linguistic responsiveness to the diverse families they serve.
Informationsplattform COVID-19 für die Primärversorgung: Entstehung
und Entwicklung einer webbasierten Wissensplattform in der COVID-19
Pandemie
Authors: Wendler Maria , Erber Patrick , Dolcic Johanna , Oswald Johannes , Rabady Susanne 
Published: March 2024

Zusammenfassung
Hintergrund Der Ausbruch von SARS-Cov-2 im Frühjahr 2020 forderte das
Gesundheitssystem und damit die primärmedizinische Versorgung in noch nie
dagewesenem Ausmaß. Das Wissen über die neue Krankheit war gering, die Dynamik
der Wissensgenerierung hoch und inhomogen. Es entstanden eine Reihe neuer
Aufgaben im Bereich der Primärversorgung in Zusammenhang mit der pandemischen
Situation. Unterstützung im Umgang mit COVID-19 war daher notwendig, obwohl
belastbare Evidenz noch nicht zur Verfügung stand. Der Informationsbedarf
bestand nicht nur hinsichtlich des Virus und der neuen Erkrankung COVID-19,
sondern auch hinsichtlich behördlicher Vorgaben und organisatorischer Fragen. In
dieser Situation wurde an der Karl Landsteiner Privatuniversität Krems eine
flexible, leicht aktualisierbare und praxistaugliche webbasierte
Wissensplattform entwickelt und als „COVID-19: Prävention und Umgang in
Primärversorgungspraxen“ am 25.03.2020 online gestellt. Wir beschreiben in
diesem Paper in Form einer restrospektiven Prozessbeschreibung zunächst den
bedarfsorientiert getriggerten Prozess der Entwicklung und Disseminierung eines
praxisorientierten Tools zur Unterstützung praktisch tätiger Hausärzt:innen in
einer Phase hoher Ungewissheit mit dringlichem Informationsbedarf. Danach wird
der Lernprozess von einem rein pragmatischen hin zu zunehmend strukturiertem
Vorgehen reflektiert und wir versuchen, Schlüsse hinsichtlich
Optimierungsmöglichkeiten in Bezug auf Erstellung und Disseminierung zu
ziehen.
Schlussfolgerung und Ausblick In Situationen hoher Ungewissheit bei
gleichzeitigem akuten Handlungs- und Entscheidungsbedarf entsteht erheblicher
Bedarf an möglichst verlässlicher Information. Wissenschaftstransfer muss so
erfolgen, dass Informationen rasch umsetzbar sind. Die Disseminierung spielt
dabei wie immer eine wesentliche Rolle. Lücken müssen in Kauf genommen werden.
Ein strukturierter Prozess der Qualitätssicherung hat parallel etabliert zu
werden. Mittel und Ressourcen für den Wissenstransfer sollten in künftigen
Pandemieplänen vorgesehen werden.
Musikerleben mit Kochleaimplantat: aktuelle neurowissenschaftliche Erkenntnisse
Authors: Hahn Laura Elisabeth , Männel Claudia , Mürbe Dirk 
Published: March 2024

AbstractCochlear implants (CIs) can provide access to music despite profound hearing loss. Yet the quality of music experience with CIs remains heterogeneous. The perception of basic musical features and more complex processing steps can be investigated using EEG, for example by relying on the mismatch paradigm and semantic priming. Future research and rehabilitation should shift in focus to the individual musical experience of CI users under everyday listening conditions.