bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cold‐Responsive Hyaluronated Upconversion Nanoplatform for Transdermal Cryo‐Photodynamic Cancer Therapy
Authors: Molkenova Anara , Choi Hye Eun , Lee Gibum , Baek Hayeon , Kwon Mina , Lee Su Bin , Park Jeong‐Min , Kim Jae‐Hyuk , Han Dong‐Wook , Park Jungwon , Hahn Sei Kwang , Kim Ki Su 
Published: March 2024

AbstractCryotherapy leverages controlled freezing temperature interventions to engender a cascade of tumor‐suppressing effects. However, its bottleneck lies in the standalone ineffectiveness. A promising strategy is using nanoparticle therapeutics to augment the efficacy of cryotherapy. Here, a cold‐responsive nanoplatform composed of upconversion nanoparticles coated with silica – chlorin e6 – hyaluronic acid (UCNPs@SiO2‐Ce6‐HA) is designed. This nanoplatform is employed to integrate cryotherapy with photodynamic therapy (PDT) in order to improve skin cancer treatment efficacy in a synergistic manner. The cryotherapy appeared to enhance the upconversion brightness by suppressing the thermal quenching. The low‐temperature treatment afforded a 2.45‐fold enhancement in the luminescence of UCNPs and a 3.15‐fold increase in the photodynamic efficacy of UCNPs@SiO2‐Ce6‐HA nanoplatforms. Ex vivo tests with porcine skins and the subsequent validation in mouse tumor tissues revealed the effective HA‐mediated transdermal delivery of designed nanoplatforms to deep tumor tissues. After transdermal delivery, in vivo photodynamic therapy using the UCNPs@SiO2‐Ce6‐HA nanoplatforms resulted in the optimized efficacy of 79% in combination with cryotherapy. These findings underscore the Cryo‐PDT as a truly promising integrated treatment paradigm and warrant further exploring the synergistic interplay between cryotherapy and PDT with bright upconversion to unlock their full potential in cancer therapy.
High‐Performance Room Temperature Ammonia Sensors Based on Pure Organic Molecules Featuring B‐N Covalent Bond
Authors: Wang Qian , Wang Meilong , Zheng Kunpeng , Ye Wanneng , Zhang Sheng , Wang Binbin , Long Xiaojing 
Published: March 2024

AbstractExploring organic semiconductor gas sensors with high sensitivity and selectivity is crucial for the development of sensor technology. Herein, for the first time, a promising chemiresistive organic polymer P‐BNT based on a novel π‐conjugated triarylboron building block is reported, showcasing an excellent responsivity over 30 000 (Ra/Rg) against 40 ppm of NH3, which is ≈3300 times higher than that of its B‐N organic small molecule BN‐H. More importantly, a molecular induction strategy to weaken the bond dissociation energy between polymer and NH3 caused by strong acid‐base interaction is further executed to optimize the response and recovery time. As a result, the BN‐H/P‐BNT system with rapid response and recovery times can still exhibit a high responsivity of 718, which is among the highest reported NH3 chemiresistive sensors. Supported by in situ FTIR spectroscopy and theoretical calculations, it is revealed that the N‐H fractions in BN‐H small molecule promoted the charge distribution on phenyl groups, which increases charge delocalization and is more conducive to gas adsorption in such molecular systems. Notably, these distinctive small molecules also promoted charge transfer and enhanced electron concentration of the P‐BNT sensing polymer, thus achieving superior B‐N‐containing organic molecules with excellent sensing performance.
Artificial Tactile Sensing Neuron with Tactile Sensing Ability Based on a Chitosan Memristor
Authors: Wang Lu , Zhang Peng , Gao Zhiqiang , Wen Dianzhong 
Published: March 2024

AbstractOwing to the highly parallel network structure of the biological neural network and its triggered processing mode, tactile sensory neurons can realize the perception of external signals and the functions of perception, memory, and data processing by adjusting the synaptic weight. In this paper, a piezoresistive pressure sensor is combined with a memristor to design an artificial tactile sensory neuron. The polyurethane sponge sensor has excellent sensitivity and can convert physical stimuli into electrical signals, and the chitosan‐based memristor has stable bipolar resistive switching characteristics, allowing further information to be memorized and processed. The neuron can respond to tactile stimuli of different degrees, durations, and frequencies; realize potentiation/depression modulation, paired‐pulse facilitation, and spike‐timing‐dependent plasticity; exhibit spike‐rate‐dependent plasticity; and store and erase tactile information through memistor state switching, which has great application potential in biological sensing systems.
Timoshenko–Ehrenfest Beam‐Based Reconfigurable Elastic Metasurfaces for Multifunctional Wave Manipulation
Authors: Lee Geon , Choi Wonjae , Ji Bonggyu , Kim Miso , Rho Junsuk 
Published: March 2024

AbstractHerein, a Timoshenko–Ehrenfest beam‐based reconfigurable elastic metasurface is introduced that can perform multifunctional wave phenomena within a single substrate, featuring high transmission in the ultrabroadband frequency range. Conventional elastic metasurfaces are typically limited to specific purposes and frequencies, thereby imposing significant constraints on their practical application. The approach involves assembly‐components with various geometries on a substrate for reconfigurability, enabling to easily control and implement multifunctional wave phenomena, including anomalous‐refraction, focusing, self‐acceleration, and total‐reflection. This is the first study on elastic metasurfaces to theoretically analyze the dispersion relation based on the Timoshenko–Ehrenfest beam theory, which considers shear deformations and rotational inertia. The analytical model is validated by demonstrating an excellent agreement with numerical and experimental results. The findings include full‐wave harmonic simulations and experimentally visualized fields for measuring various wave modulations. Furthermore, the practicality of the system is verified by significantly enhancing the piezoelectric energy harvesting performance within the focusing configuration. It is believed that the reconfigurable elastic metasurface and analytical model based on the Timoshenko–Ehrenfest beam theory have vast applications such as structural health monitoring, wireless sensing, and Internet of Things.
Reactive Oxygen Species‐Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression
Authors: Qi Liang , Duan Bo‐Wen , Wang Hui , Liu Yan‐Jun , Han Han , Han Meng‐Meng , Xing Lei , Jiang Hu‐Lin , Pandol Stephen J. , Li Ling 
Published: March 2024

AbstractPancreatic fibrosis (PF) is primarily characterized by aberrant production and degradation modes of extracellular matrix (ECM) components, resulting from the activation of pancreatic stellate cells (PSCs) and the pathological cross‐linking of ECM mediated by lysyl oxidase (LOX) family members. The excessively deposited ECM increases matrix stiffness, and the over‐accumulated reactive oxygen species (ROS) induces oxidative stress, which further stimulates the continuous activation of PSCs and advancing PF; challenging the strategy toward normalizing ECM homeostasis for the regression of PF. Herein, ROS‐responsive and Vitamin A (VA) decorated micelles (named LR‐SSVA) to reverse the imbalanced ECM homeostasis for ameliorating PF are designed and synthesized. Specifically, LR‐SSVA selectively targets PSCs via VA, thereby effectively delivering siLOXL1 and resveratrol (RES) into the pancreas. The ROS‐responsive released RES inhibits the overproduction of ECM by eliminating ROS and inactivating PSCs, meanwhile, the decreased expression of LOXL1 ameliorates the cross‐linked collagen for easier degradation by collagenase which jointly normalizes ECM homeostasis and alleviates PF. This research shows that LR‐SSVA is a safe and efficient ROS‐response and PSC‐targeted drug‐delivery system for ECM normalization, which will propose an innovative and ideal platform for the reversal of PF.
Tailoring Type III Porous Ionic Liquids for Enhanced Liquid‐Liquid Two‐Phase Catalysis
Authors: Wu Peiwen , Wang Bangzhu , Chen Linlin , Zhu Jie , Yang Ning , Zhu Linhua , Deng Chang , Hua Mingqing , Zhu Wenshuai , Xu Chunming 
Published: March 2024

AbstractPorous Ionic Liquids (PILs) have gained attention but facing challenges in catalysis, especially in liquid‐liquid two‐phase reactions due to limited catalytic sites and hydrophilicity control. This work engineered a Type III PILs (PILS‐M) using zeolitic imidazolate framework‐8 (ZIF‐8) confined phosphomolybdic acid (HPMo) as the microporous framework and N‐butyl pyridine bis(trifluoromethane sulfonyl) imide ionic liquid ([Bpy][NTf2]) as the solvent. The PILS‐M not only combines the advantages of traditional ionic liquids and microporous frameworks, including excellent extraction, high dispersion of catalytically active species, remarkable stability, etc., but also can make the inner surface of ZIF‐8 turned to be hydrophilic that favors the contact between aqueous hydrogen peroxide oxidant and catalytically active sites for the promotion of catalytic performance in reactive extractive desulfurization (REDS) processes of fuel oils. This study demonstrates Type III PILs' potential as catalysts for sustainable chemical processes, offering insights into versatile PILs applications in diverse fields.
Unravelling the Mechanism of Pulse Current Charging for Enhancing the Stability of Commercial LiNi0.5Mn0.3Co0.2O2/Graphite Lithium‐Ion Batteries
Authors: Guo Jia , Xu Yaolin , Exner Moritz , Huang Xinrong , Li Yongchun , Liu Yanchen , Wang Hui , Kowal Julia , Zhang Qi , Kristensen Peter Kjær , Wang Deyong , Pedersen Kjeld , Gurevich Leonid , Stroe Daniel‐Ioan , Adelhelm Philipp 
Published: March 2024

AbstractThe key to advancing lithium‐ion battery (LIB) technology, particularly with respect to the optimization of cycling protocols, is to obtain comprehensive and in‐depth understanding of the dynamic electrochemical processes during battery operation. This work shows that pulse current (PC) charging substantially enhances the cycle stability of commercial LiNi0.5Mn0.3Co0.2O2 (NMC532)/graphite LIBs. Electrochemical diagnosis unveils that pulsed current effectively mitigates the rise of battery impedance and minimizes the loss of electrode materials. Operando and ex situ Raman and X‐ray absorption spectroscopy reveal the chemical and structural changes of the negative and positive electrode materials during PC and constant current (CC) charging. Specifically, Li‐ions are more uniformly intercalated into graphite and the Ni element of NMC532 achieves a higher energy state with less Ni─O bond length variation under PC charging. Besides, PC charging suppresses the electrolyte decomposition and continuous thickening of the solid‐electrolyte‐interphase (SEI) layer on graphite anode. These findings offer mechanistic insights into Li‐ion storage in graphite and NMC532 and, more importantly, the role of PC charging in enhancing the battery cycling stability, which will be beneficial for advancing the cycling protocols for future LIBs and beyond.
Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome
Authors: Hillerstrom Hampus , Fisher Richard , Janicki Matthew P. , Chicoine Brian , Christian Bradley T. , Esbensen Anna , Esralew Lucille , Fortea Juan , Hartley Sigan , Hassenstab Jason , Keller Seth M. , Krinsky‐McHale Sharon , Lai Florence , Levin Johannes , McCarron Mary , McDade Eric , Rebillat Anne Sophie , Rosas Herminia Diana , Silverman Wayne , Strydom Andre , Zaman Shahid H. , Zetterberg Henrik 
Published: March 2024

AbstractPrior authorization criteria for Federal Drug Administration (FDA) approved immunotherapeutics, among the class of anti‐amyloid monoclonal antibodies (mAbs), established by state drug formulary committees, are tailored for adults with late‐onset Alzheimer's disease. This overlooks adults with Down syndrome (DS), who often experience dementia at a younger age and with different diagnostic assessment outcomes. This exclusion may deny DS adults access to potential disease‐modifying treatments. To address this issue, an international expert panel convened to establish adaptations of prescribing criteria suitable for DS patients and parameters for access to Centers for Medicare & Medicaid Services (CMS) registries. The panel proposed mitigating disparities by modifying CMS and payer criteria to account for younger onset age, using alternative language and assessment instruments validated for cognitive decline in the DS population. The panel also recommended enhancing prescribing clinicians' diagnostic capabilities for DS and initiated awareness‐raising activities within healthcare organizations. These efforts facilitated discussions with federal officials, aimed at achieving equity in access to anti‐amyloid immunotherapeutics, with implications for national authorities worldwide evaluating these and other new disease‐modifying therapeutics for Alzheimer's disease.
Is High‐Frequency Activity at Seizure Onset Inhibitory? A Stereoelectroencephalographic Study of Motor Cortex Seizures
Authors: Shaker Hussam , Li Jian , Kobayashi Masako , Grinenko Olesya , Bulacio Juan , Leahy Richard M. , Chauvel Patrick 
Published: March 2024

ObjectiveIn the era of stereoelectroencephalography (SEEG), many studies have been devoted to understanding the role of interictal high‐frequency oscillations. High‐frequency activity (HFA) at seizure onset has been identified as a marker of epileptogenic zone. We address the physiological significance of ictal HFAs and their relation to clinical semiology.MethodsWe retrospectively identified patients with pure focal primary motor epilepsy. We selected only patients in whom SEEG electrodes were optimally placed in the motor cortex as confirmed by electrical stimulation. Based on these narrow inclusion criteria, we extensively studied 5 patients (3 males and 2 females, mean age = 22.4 years) using time–frequency analysis and time correlation with motor signs onset.ResultsA total of 157 analyzable seizures were recorded in 5 subjects. The first 2 subjects had tonic or clonic semiology with rare secondary generalization. Subject 3 had atonic onset followed by clonic hand/arm flexion. Subject 4 had clusters of tonic and atonic facial movements. Subject 5 had upper extremity tonic movements. The median frequency of the fast activity extracted from the Epileptogenic Zone Fingerprint pipeline in the first 4 subjects was 76 Hz (interquartile range = 21.9Hz). Positive motor signs did not occur concomitantly with high gamma activity developing in the motor cortex. Motor signs began at the end of HFAs.InterpretationThis study supports the hypothesis of an inhibitory effect of ictal HFAs. The frequency range in the gamma band was associated with the direction of the clinical output effect. Changes from inhibitory to excitatory effect occurred when discharge frequency dropped to low gamma or beta. ANN NEUROL 2024;95:1127–1137
A pan‐cheloniid turtle from the Middle Miocene of Portugal
Authors: Pérez‐García Adán , Antunes Miguel Telles 
Published: March 2024

AbstractCurrently, there is no information on the fossil record of Pan‐Cheloniidae from the Neogene of the Iberian Peninsula. A well‐preserved partial skeleton attributable to this lineage of turtles, from the Middle Miocene of Portugal, is presented here. It preserves much of the anterior half of its carapace, in which the plates remain articulated, as well as several articulated dorsal vertebrae, and an isolated cervical and a caudal vertebrae. The analysis of this Serravallian find shows that it cannot be attributed to a hitherto described taxon. Thus, a new member of Pan‐Cheloniidae is defined, Lusochelys emilianoi gen. et sp. nov., improving the relatively limited knowledge about this lineage for the Middle Miocene global record. It represents the first generic and specific systematic attribution for a member of Pan‐Chelonioidea in the Neogene record of the Iberian Peninsula.
Synthesis of Naphthalimide Azocarboxylates Showing Turn‐On Fluorescence by Substitution Reaction with Sulfinates**
Authors: Tanimoto Hiroki , Kyogaku Shogo , Otsuki Aoi , Tomohiro Takenori 
Published: March 2024

AbstractThe synthesis and characterization of sulfinate addition‐responsive fluorescent molecules are described. We found that addition reaction of sulfinates to naphthalimide‐substituted azocarboxylates afforded the corresponding sulfonyl hydrazides with high fluorescence quantum yields (up to 0.91 in THF and 0.54 in methanol), which exhibited a large Stokes shift (105 nm) in protic methanol solvent, while the unsubstituted hydrazide and the sulfonyl‐position isomer showed no fluorescence in polar solvents.
Core‐Shell Architectured Sulfur Coated α‐Fe2O3 Nano‐Sheet Anode for Li‐Ion Battery with Insitu Active Solid Electrolyte Interfacial Layer and Li‐Sulfur Energy Storage Systems
Authors: Kasiviswanathan Kavibharathy , Prashant Hanamantrao Desai , Ramakrishnan Saraswathi , Raj Sajan , Kumaresan Lakshmanan , Paulraj Vivek , Chenrayan Senthil , Rangasamy Baskaran , Vediappan Kumaran 
Published: March 2024

AbstractA versatile approach is achieved through the surface coating of sulfur on α‐Fe2O3 nanosheet by microwave treatment that inherently supports the formation of self‐induced active solid electrolyte interface (SEI) layer which effectively protects the electrode surface and enhances the cyclic stability of lithium‐ion battery. The present findings on a sulfur‐coated α‐Fe2O3@S‐2 core‐shell structured anode demonstrates an initial specific capacity of 1194 mAh g−1 at a 0.1 C rate, and an average discharge capacity of 518 mAh g−1 over 20 cycles. Sulfur coating proves the incredible development of an active SEI layer that prevents electrolyte decomposition and the electrode persuades with stable capacity, fast rate capability and retains excellent coulombic efficiency for 500 cycles in LIB. GITT measurements exhibit superior Li+ ion diffusion coefficient
2.87×10−10 cm2 s−1 at 80 % SOC for the α‐Fe2O3@S‐2 electrode. The in‐depth ex‐situ evaluations uncovered a fascinating self‐assembled active Li2SO4 electrode‐electrolyte interface formation in the sulfur‐coated α‐Fe2O3 electrode that contributes interfacial kinetics. The sulfur coated α‐Fe2O3 electrode exhibits an exceptional high‐rate performance and coulombic efficiency even in lithium‐sulfur battery. This research overthrows sulfur‘s significance in forming an active interfacial bridging SEI layer that facilitates lithium‐ion kinetics across the interface and alleviates undesirable SEI development.
Design, fabrication, automation, and scaleup of anaerobic reactors for waste management and bioenergy recovery
Authors: Fröner‐Lacerda Luana R. R. , Sganzerla William Gustavo , Lacerda Vinícius F. , Sillero Leonor , Solera Rosario , Pérez Montserrat , Forster‐Carneiro Tânia 
Published: March 2024

AbstractDigitally controlled reactors can optimize biological reactions and process control through a neural network system. This study reports on the design, fabrication, and automation of a laboratory‐scale anaerobic reactor for the management of agrifood byproducts and bioenergy recovery. The process described here can digitally control the operational parameters, which is beneficial for stable methane production. The proposed process comprises the digital measurement of temperature, pH, humidity, biogas volume, and methane composition by integrating the data in a processor module. The proposed automated reactor can assist significantly in controlling and monitoring the anaerobic digestion process, providing decision making during waste management and bioenergy recovery. A case study is described with the application of automated reactors in a pilot‐scale plant, operated with the flow of 8 m3 slaughterhouse wastewater per day and a biogas production of 10 m3 h−1. The automated pilot‐scale process presents many advantages, including a continuous mode of operation and a faster adaptation of the microorganisms to the substrate, improving biogas production.
Enhanced targeting: Production of filamentous bacteriophage monoclonal antibodies using the major coat protein pVIII as anchor
Authors: Li Qing , Zhu Jianyu , Yuan Ting , Dou Leina , Yu Xuezhi , Shen Jianzhong , Yang Huijuan , Wang Zhanhui 
Published: March 2024

AbstractFilamentous bacteriophage display technology has been employed in antibody discovery, drug screening, and protein–protein interaction study across various fields, including food safety, agricultural pollution, and environmental monitoring. Antifilamentous bacteriophage antibodies for identifying filamentous bacteriophage are playing a pivotal role in this technology. However, the existing antifilamentous bacteriophage antibodies lack sensitivity and specificity, and the antibodies preparation methods are cumbersome and hyposensitive. The major coat protein pVIII of filamentous bacteriophage has an advantage in quantification, which is benefit for detecting signal amplification but its full potential remains underutilized. In this study, the partial polypeptide CT21 of the major coat protein pVIII of filamentous bacteriophage was intercepted as the targeted immunogen or coating antigen to prepare antifilamentous bacteriophage antibodies. Six filamentous bacteriophage‐specific monoclonal antibodies (mAbs) M5G8, M9A2, P6B5, P6D2, P8E4, and P10D4 were obtained. The limit of detections of the prepared six mAbs for detecting filamentous bacteriophage was 1.0 × 107 pfu mL−1. These mAbs stayed stable under different pH, temperature, and exhibited high specificity in real application. This study not only provides a new idea for simplifying the preparation of antifilamentous bacteriophage antibodies which could apply in filamentous bacteriophage display, but it also presents a novel strategy for preparing antibodies against protein‐specific epitopes with high sensitivity.
Modification of nitrilase based on computer screening and efficient biosynthesis of 4‐cyanobenzoic acid
Authors: Jin Yi‐Zhong , Shen Ji‐Dong , Wang Yu‐xin , Shao Hong‐Ming , Xia Hai‐Jian , Lin Jiao‐Hua , Liu Zhi‐Qiang , Zheng Yu‐Guo 
Published: March 2024

Abstract4‐cyanobenzoic acid serves as a crucial intermediate for the synthesis of various high‐value organic compounds. The enzymatic hydrolysis of terephthalonitrile to produce 4‐cyanobenzoic acid using nitrilase offers the advantages of a simple reaction pathway, environmental friendliness, and easy product separation. In order to efficiently develop nitrilases that meet industrial production requirements, the virtual screening method used in the study is established and mature. From a total of 371 amino acids in the nitrilase AfNIT, which exhibits activity in terephthalonitrile hydrolysis, three candidate sites (F168, S192, and T201) were identified, and a “small and accurate” mutant library was constructed. The triple mutant F168V/T201N/S192F was screened from this small mutant library with a specific activity of 227.3 U mg−1, which was 3.8 times higher than that of the wild‐type AfNIT. Using the whole‐cell biocatalyst containing the mutant F168V/T201N/S192F, terephthalonitrile was successfully hydrolyzed at a concentration of 150 g L−1 to produce 4‐cyanobenzoic acid with a final yield of 170.3 g L−1 and a conversion rate of 98.7%. The obtained nitrilase mutant F168V/T201N/S192F in this study can be effectively applied in the biomanufacturing of 4‐cyanobenzoic acid using terephthalonitrile as a substrate. Furthermore, the results also demonstrate the significant improvement in predictive accuracy achieved through the latest AI‐assisted computer simulation methods. This approach represents a promising and feasible new technological pathway for assisting enzyme engineering research, laying a theoretical foundation for other related studies.