bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Komponen Pertumbuhan Ekonomi Kabupaten Bogor dan Faktor-Faktor yang Mempengaruhinya
Authors: Hakim Dedi Budiman , Hadianto Adi , Panjaitan Dian Verawati , Wijayanti Windi 
Published: March 2024

Perekonomian Kabupaten Bogor saling terkait antar sektor dan antar wilayah. Tumbuh dan berkembangnya Kabupaten Bogor sangat dipengaruhi oleh aspek spasial dan komponen-komponen lain penentu pertumbuhan wilayah Kabupaten Bogor. Oleh karena itu, perlu dianalisis komponen penentu pertumbuhan ekonomi di Kabupaten Bogor dan faktor-faktor yang menjadi penentu pertumbuhan ekonomi wilayah itu sendiri. Metode analisis komponen pertumbuhan adalah LQ, SS, SQx, LQx, MC, dan SP. Sedangkan untuk menganalisis faktor-faktor yang mempengaruhi pertumbuhan ekonomi Kabupaten Bogor digunakan metode OLS. Hasil analisis menunjukkan bahwa industri pengolahan merupakan salah satu sektor ekonomi yang menjadi basis dalam pembangunan ekonomi di Kabupaten Bogor. Disamping itu, terdapat sektor lain yang memiliki peran penting dalam mendorong pertumbuhan ekonomi di Kabupaten Bogor. Semua sektor ini tidak berdiri sendiri dan memiliki posisi saling mendukung baik sebagai sumber pasokan (backward linkages) maupun pasar produk (forward linkages). Faktor-faktor yang signifikan memengaruhi pertumbuhan ekonomi adalah luas wilayah, populasi, dan jumlah koperasi. Dalam konteks pertumbuhan ekonomi, fokus pembangunan dapat diarahkan pada sektor basis di setiap kecamatan. Namun agar terjadi pemerataan pembangunan (equity), pengembangan pertanian dalam arti luas dan kehutanan tetap menjadi prioritas karena banyak masyarakat yang tergantung kehidupannya dari kedua sektor ini.Kata Kunci: basis, ekonomi, kecamatan, pertumbuhan
Transformasi Digital di Bidang Kesehatan: Analisis Dampak Inovasi Digital di Puskesmas Kabupaten Bogor Tahun 2022
Authors: Harmi Ospri 
Published: March 2024

Transformasi digital di sektor kesehatan telah menjadi topik yang semakin populer dan penting dalam beberapa tahun terakhir. Pemerintah Indonesia dan institusi kesehatan telah mulai memperkenalkan inovasi digital di berbagai tingkat sistem kesehatan, termasuk di pusat kesehatan masyarakat (Puskesmas). Inovasi digital yang diterapkan di Puskesmas Kabupaten Bogor meliputi sistem informasi manajemen puskesmas, layanan konsultasi dokter online, penggunaan teknologi untuk pemantauan kesehatan jarak jauh pasien, dan lain sebagainya. Inovasi ini telah berkembang terutama sejak munculnya pandemi Covid-19, yang menyebabkan pembatasan pertemuan tatap muka dan mengarah pada gagasan baru tentang akses layanan. Penelitian ini bertujuan untuk menganalisis perubahan kualitas layanan yang terjadi sebagai dampak dari implementasi inovasi termasuk memetakan jenis-jenis perubahan dan model evaluasi. Metode penelitian yang digunakan adalah kuantitatif dan kualitatif (eksplorasi) dengan memilih metode Before After Comparison (kuantitatif) dan Post Test Without Comparison Group and Baseline Data (kualitatif). Hasil penelitian menunjukkan bahwa inovasi digital yang dilaksanakan oleh puskesmas di Kabupaten Bogor menunjukkan adanya peningkatan dalam output layanan Selain itu, inovasi digital tersebut berdampak langsung terhadap efisiensi biaya, SDM pelaksana, dan waktu layanan.Kata Kunci: dampak inovasi, inovasi digital, puskesmas
Chemical and Functional Properties of Pasting Producing from Plantain, Mesquite Seed Flours and Rice Bran
Authors: Emojorho Ernest Eguono , Udeh Charles Chiedu , Anene Maryann Nkemakonam , Aphiar Agnes , Nwosu Adaora Ngozi , Ochimana Titus Onucheojo 
Published: March 2024

The goal of the study was to see whether plantain flour could be blended with rice bran and mesquite flour to produce composite flour that might be included in the diet of some people with health issues. According to the findings, the chemical composition of the top-rated enriched composite flour showed 10.41 to 14.70 % moisture, 3.37 to 11.70 % protein, 62.79 to 80.74 % carbohydrate, 1.35 to 1.71 % ash, 3.68 to 0.37 % fibre and 0.30 to 0.58 % fat. Mineral composition showed calcium 3.08 to 4.00 mg/100g, potassium 5.03 to 6.65 mg/100g, zinc 0.038 to 0.053 mg/100g, iron 0.029 to 0.038 mg/100g and sodium 0.51 to 0.80 mg/100g. Functional properties showed swelling capacity 3.85 g/g to 4.26 g/g, bulk density 0.40 to 0.44 g/cm3, solubility 6.94 to 17.35 % , water absoption capacity 58.00 to 59.80 %. Therefore, adding up to 30% of rice bran and mesquite flour to the composite flour mix would enhance its nutritional value.
Evaluation of Germplasm for Seedling Stage Salinity Tolerance in Rice (Oryza Sativa L.)
Authors: Pranaya J , Roja V , Rao P Venkata Ramana , Rani M Girija , Ramesh D 
Published: March 2024

Salinity affects rice growth and development. Mostly all growth stages from germination to maturity are affected by the salinity. Among all the stages, seedling and reproductive stages are the most sensitive stages to salinity, which results in considerable yield losses. Development of salt tolerant varieties is most feasible approach for improving the production of rice in salt affected soils as seedling stage is necessary for better crop improvement. Overall 76 rice germplasm lines were evaluated at RARS, Maruteru, West Godavari, A.P during Kharif 2020 for salinity tolerance at seedling stage. The different parameters like root length, shoot length, shoot Na+ content, shoot K+ content, Na+/K+ content and SIS (salt injury score) at 10th and 16th day were studied under hydroponics subjecting to electrical conductivity of 6 and 12 dSm-1, at a pH of 5.0. Salinity scoring during seedling stage was noted as per the modified standard evaluation score (SES) of IRRI, revealed that four genotypes FL478, MTU1290, MTU1061 and MCM109 as tolerant, 23 genotypes as moderately tolerant, 42 were susceptible and remaining seven genotypes namely BPT2848, BPT3140, Hallabhatta, MTU1271, MTU1121, BPT2846 and Krishnahamsa are highly susceptible. The phenotypic study signified that Na+/K+ ratio is the key note for salinity tolerance.
Assessment of Variability for Herbage Yield and Its Component Traits in Genotypes of Kalmegh (Andrographis paniculata) (Burm. f.) Wall. ex Nees
Authors: Dharshini M. S. , Geetha K. A. 
Published: March 2024

The study was conducted during the 2019 Kharif with the goals of estimating variability, heritability and genetic advance among all the genotypes in a Randomized Block Design with three replications. Based on variability studies, it could be concluded that the characters viz., plant height (9.93% & 81.81%), leaf width (15.06% & 80.05%), leaf area (10.62% & 81.91%), number of secondary branches (17.29% & 56.59%), total length of primary branches per plant (15.19% & 75.81%), canopy spread (12.81% & 75.33%), length of internodes (13.59% & 79.01%), angle of primary branch (66.32% & 94.01%), all the yield parameters except leaf dry matter content (9.33% & 69.82%) and stem dry matter content (6.82% & 59.22%) and all the chemical parameters had sufficient amount of variability, high heritability respectively. Therefore, simple selection methods will be more effective for improvement of these characters.
Prenatal diagnosis using cell‐free nucleic acids in maternal body fluids: A decade of progress
Authors: Maron Jill L. , Bianchi Diana W. 
Published: February 2007

AbstractThe ability to detect cell‐free fetal nucleic acids in pregnant women has greatly evolved over the past decade. Dozens of papers have explored the biology, kinetics, and clinical significance of both cell‐free fetal DNA and mRNA in the maternal circulation. As a result, our overall understanding of fetal nucleic acid trafficking has expanded. To date, two applications, gender determination and fetal RhD status, have translated into clinical medicine. However, with advanced molecular techniques such as mass spectrometry, real‐time quantitative polymerase chain reaction, and gene expression arrays, the ease with which fetal genes can be detected within the mother has greatly improved. Newly identified placental and fetal mRNA transcripts as well as an epigenetically modified placental DNA marker, maspin, have universal applicability. Global expression analyses of fetal mRNA in both amniotic fluid and blood provide new insights into fetal development and pathology. Prenatal diagnosis is poised to evolve from detection of aneuploidy to detection of deviation from normal development, which should provide novel opportunities for fetal treatment. © 2007 Wiley‐Liss, Inc.
Ratiometric and Near‐Infrared Molecular Probes for the Detection and Imaging of Zinc Ions
Authors: Carol Priya , Sreejith Sivaramapanicker , Ajayaghosh Ayyappanpillai 
Published: February 2007

AbstractThe detection and imaging of Zn2+ in biological samples are of paramount interest owing to the role of this cation in physiological functions. This is possible only with molecular probes that specifically bind to Zn2+ and result in changes in emission properties. A “turn‐on” emission or shift in the emission color upon binding to Zn2+ should be ideal for in vivo imaging. In this context, ratiometric and near‐IR probes are of particular interest. Therefore, in the area of chemosensors or molecular probes, the design of fluorophores that allow ratiometric sensing or imaging in the near‐IR region is attracting the attention of chemists. The purpose of this Focus Review is to highlight recent developments in this area and stress the importance of further research for future applications.
An Improved Ruthenium Catalyst for the Environmentally Benign Amination of Primary and Secondary Alcohols
Authors: Hollmann Dirk , Tillack Annegret , Michalik Dirk , Jackstell Ralf , Beller Matthias 
Published: February 2007

AbstractThe N‐alkylation of amines in the presence of different ruthenium catalysts generated in situ was investigated. Among the various catalysts tested, the combination of [Ru3(CO)12] and N‐phenyl‐2‐(dicyclohexylphosphanyl)pyrrole showed the best performance. By applying this novel catalyst, a variety of functionalized alcohols and amines were converted into the corresponding secondary amines in high yield.
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats
Authors: Zhu Xuan , Lee Dae Y. , Shin Wan G. 
Published: February 2007

AbstractThe possible reason for the significantly greater AUC of oral warfarin with oral oxolamine in male Sprague−Dawley rats was evaluated. After oral administration of warfarin at a dose of 2 mg/kg to male rats with oxolamine at doses of 10 and 50 mg/kg, the AUC values of warfarin were significantly greater than the controls (254 and 330 versus 180 µg h/ml). However, the AUC values of warfarin were not affected by oxolamine in female rats. This could be due to inhibition of CYP2B1, 2C11 and 3A2 by oxolamine in male rats, since warfarin was metabolized via CYP1A1, 2B1, 2C6, 2C11 and 3A2 in rats and CYP2B1 is male dominant, and CYP2C11 and 3A2 are male specific. Therefore, phenytoin, torasemide and clarithromycin (mainly metabolized via CYP2B1/2, 2C11 and 3A2 in rats, respectively) were administered intravenously to male rats with or without oral oxolamine. After oral oxolamine at doses of 10 and 50 mg/kg, the AUC of phenytoin was significantly greater (1280 and 1640 versus 938 µg min/ml), however, the AUC values of torasemide and clarithromycin were independent of oxolamine. The above data suggest that the significantly greater AUC of oral warfarin with oral oxolamine could be due to inhibition of CYP2B1/2 by oxolamine in male rats. Copyright © 2007 John Wiley & Sons, Ltd.
Recent advances in pharmacokinetic modeling
Authors: Ahmad Alaa M. 
Published: February 2007

AbstractA major part of the science of pharmacokinetics is the modeling of the underlying processes that contribute to drug disposition. The purpose of pharmacokinetic models is to summarize the knowledge gained in preclinical and clinical studies at various stages in drug development and to rationally guide future studies with the use of adequately predictive models. This review highlights a variety of recent advances in mechanistic pharmacokinetic modeling. It is aimed at a broad audience, and hence, an attempt was made to maintain a balance between technical information and practical applications of pharmacokinetic modeling. It is hoped that drug researchers from all disciplines would be able to get a flavor of the function and capacity of pharmacokinetic modelers and their contribution to drug development. While this review is not intended to be a technical reference on modeling approaches, the roles of statistical applications and population methodologies are discussed where appropriate. Copyright © 2007 John Wiley & Sons, Ltd.
Role of plasma as activator and cofactor in phosphorylation catalyzed by protein kinase C
Authors: Kang Jeong‐Hun , Asai Daisuke , Oishi Jun , Kawamura Kenji , Toita Riki , Jiang Yuhua , Mori Takeshi , Niidome Takuro , Katayama Yoshiki 
Published: February 2007

AbstractThe purpose of this study was to investigate whether plasma can influence the phosphorylation of protein kinase C (PKC). Lysate samples were prepared from normal skin or melanoma tissue and were reacted with a PKC peptide substrate in the presence or absence of plasma. In normal skin tissue lysates, the phosphorylation rates were much lower than those in melanoma tissue lysates. However, the level of phosphorylated peptide was increased in both normal skin and melanoma tissue lysates if plasma was present. Phosphorylation rates in the samples taken from the centre of B16 melanoma tissue were lower than those in samples taken from the edge. Moreover, addition of activator and/or cofactors (diacylglycerol, phosphatidylserine and/or Ca2+) of PKC, or plasma to the lysates contaminated by plasma had no effect on phosphorylation rates for the peptide substrate. These results indicate that plasma can play a role of activator and cofactor for substrate phosphorylation. Copyright © 2007 John Wiley & Sons, Ltd.
Is patent foramen ovale closure effective in reducing migraine symptoms? A controlled study
Authors: Kimmelstiel Carey , Gange Christopher , Thaler David 
Published: February 2007

AbstractObjectives:We investigated the prevalence of migraine in patients with patent foramen ovale (PFO), and the effect of PFO closure on migraine symptoms and medications.Background:Studies have shown an association between migraine and PFO. Data have recently suggested a reduction in migraine symptoms following PFO closure. Most of these studies had no controls.Methods:Subjects were divided into three groups: No PFO (Controls, n = 65), PFO with no intervention (“Open PFO”, n = 63), and PFO treated with percutaneous closure (“Closed PFO”, n = 41). We measured the frequency, severity, and impact of migraine on quality of life employing MIDAS scores. Comparisons were made preceding and 90 days after either transesophageal echocardiography (Controls and “Open PFO”) or PFO closure (“Closed PFO”). We compared the use of abortive medications between the two time points.Results:Migraine, especially with aura, was more prevalent in both PFO groups (P < 0.05). Migraine frequency was reduced by 83% in Closed PFO compared with 0% of Open PFO and 10% of control patients (P < 0.0001). Migraine severity and MIDAS scores were reduced by PFO closure when compared to the other two groups (P < 0.0001, P = 0.035 respectively). Reduction in abortive medications was noted in 71% after closure, 5% of Open PFO, and 10% of Controls (P < 0.001).Conclusions:In this controlled study, migraine, especially with aura, is more frequent in subjects with PFO. PFO closure is associated with a reduction in migraine frequency and severity, as well as an improvement in MIDAS scores. PFO closure was associated with a significant reduction in the use of abortive medications. © 2007 Wiley‐Liss, Inc.
Recurrent very late stent thrombosis after bare‐metal stent implantation
Authors: Saito T. , Asajima H. 
Published: February 2007

AbstractVery late bare‐metal stent thrombosis occurring beyond 1 year after stenting is uncommon. Although much attention has been paid for late stent thrombosis, long‐term outcome of patients who developed late stent thrombosis is not clear. We report a case of recurrent very late stent thrombosis after bare‐metal stent implantation. © 2007 Wiley‐Liss, Inc.
Long Synthetic Nanotubes from Calix[4]arenes
Authors: Organo Voltaire G. , Sgarlata Valentina , Firouzbakht Farhood , Rudkevich Dmitry M. 
Published: February 2007

AbstractWe report the synthesis and encapsulation properties of long (up to 5 nm) molecular nanotubes 1–4, which are based on calix[4]arenes and can be filled with multiple nitrosonium (NO+) ions upon reaction with NO2/N2O4 gases. These are among the largest nanoscale molecular containers prepared to date and can entrap up to five guests. The structure and properties of tubular complexes 1⋅(NO+)2–4⋅(NO+)5 were studied by UV/Vis, FTIR, and 1H NMR spectroscopy in solution, and also by molecular modeling. Entrapment of NO+ in 1⋅(NO+)2–4⋅(NO+)5 is reversible, and addition of [18]crown‐6 quickly recovers starting tubes 1–4. The FTIR and titration data revealed enhanced binding of NO+ in longer tubes, which may be due to cooperativity. The described nanotubes may serve as materials for storing and converting NOx and also offer a promise to further develop supramolecular chemistry of molecular containers. These findings also open wider perspectives towards applications of synthetic nanotubes as alternatives to carbon nanotubes.
Inverted Supercritical Carbon Dioxide/Aqueous Biphasic Media for Rhodium‐Catalyzed Hydrogenation Reactions
Authors: Burgemeister Katja , Franciò Giancarlo , Gego Volker H. , Greiner Lasse , Hugl Herbert , Leitner Walter 
Published: February 2007

AbstractAn inverted supercritical carbon dioxide (scCO2)/aqueous biphasic system has been used as reaction media for Rh‐catalysed hydrogenation of polar substrates. Chiral and achiral CO2‐philic catalysts were efficiently immobilised in scCO2 as the stationary phase, while the polar substrates and products were contained in water as the mobile phase. Notably, product separation and catalyst recycling were conducted without depressurisation of the autoclave. The catalyst phase was reused several times with high conversion and product recovery of more than 85 %. Loss of rhodium and phosphorus by leaching were found to be below the detection limit after the first two cycles in the majority of repetitive experiments. The reaction conditions were optimised with a minimum of experiments by using a simplex algorithm in a sequential optimisation. Total turnover numbers (TTNs) of up to 1600, turnover frequencies (TOFs) of up to 340 h−1 and ee's up to 99 % were obtained in repetitive batch operations. The scope of the devised catalytic system has been investigated and a semicontinuous reaction setup has been implemented. The chiral ligand (R,S)‐3‐H2F6‐BINAPHOS allowed highly enantioselective hydrogenation of itaconic acid and methyl‐2‐acetamidoacrylate combined with a considerable catalyst stability in these reaction media.
The Synthesis, Structure and Reactivity of B(C6F5)3‐Stabilised Amide (MNH2) Complexes of the Group 4 Metals
Authors: Mountford Andrew J. , Clegg William , Coles Simon J. , Harrington Ross W. , Horton Peter N. , Humphrey Simon M. , Hursthouse Michael B. , Wright Joseph A. , Lancaster Simon J. 
Published: February 2007

AbstractTreatment of the homoleptic titanium amides [Ti(NR2)4] (R=Me or Et) with the Brønsted acidic reagent H3N⋅B(C6F5)3 results in the elimination of one molecule of amine and the formation of the four‐coordinate amidoborate complexes [Ti(NR2)3{NH2B(C6F5)3}], the identity of which was confirmed by X‐ray crystallography. The reaction with [Zr(NMe2)4] proceeds similarly but with retention of the amine ligand to give the trigonal‐bipyramidal complex [Zr(NMe2)3{NH2B(C6F5)3}(NMe2H)]. Cyclopentadienyl (Cp) amidoborate complexes, [MCp(NR2)2{NH2B(C6F5)3}] (M=Ti, R=Me or Et; M=Zr, R=Me) can be prepared from [MCp(NR2)3] and H3N⋅B(C6F5)3, and exhibit greater thermal stability than the cyclopentadienyl‐free compounds. H3N⋅B(C6F5)3 reacts with nBuLi or LiN(SiMe3)2 to give LiNH2B(C6F5)3, which complexes with strong Lewis acids to form ion pairs that contain weakly coordinating anions. The attempted synthesis of metallocene amidoborate complexes from dialkyl or diamide precursors and H3N⋅B(C6F5)3 was unsuccessful. However, LiNH2B(C6F5)3 does react with the highly electrophilic reagents [MCp2Me(μ‐Me)B(C6F5)3] to give [MCp2Me(μ‐NH2)B(C6F5)3] (M=Zr or Hf). Comparison of the molecular structures of the Group 4 amidoborate complexes reveals very similar BN, TiN and ZrN bond lengths, which are consistent with a description of the bonding as a dative interaction between an {M(L)n(NH2)} fragment and the Lewis acid B(C6F5)3. Each of the structures has an intramolecular hydrogen‐bonding arrangement in which one of the nitrogen‐bonded hydrogen atoms participates in a bifurcated F⋅⋅⋅H⋅⋅⋅F interaction to ortho‐F atoms.
Optimal Attachment Position and Linker Length Promote Native‐like Character of Cavitand‐Based Template‐Assembled Synthetic Proteins (TASPs)
Authors: Seo Emily S. , Scott Walter R. P. , Straus Suzana K. , Sherman John C. 
Published: February 2007

AbstractWe have designed, synthesised and characterised a series of template‐assembled de novo four‐helix bundles, each differing in the linker length between the template and the peptides. The helix is based on an earlier peptide sequence: EELLKKLEELLKKLG (first‐generation sequence), which was designed to link the hydrophilic/hydrophobic interface of the helices. Increasing or decreasing the linker length by one glycine residue had a significant effect on the structure and properties of the template‐assembled synthetic proteins (TASPs). Here, the effect of the linker length is further probed by linking the peptides closer to the hydrophobic face by using the second‐generation sequence, AEELLKKLEELLKKG, in an effort to improve the packing between the helices and to better understand the helical bundles. The peptides were synthesised with 0–4 Gly linker residues and linked onto a cavitand template. The proteins were found to be α‐helical, stable to guanidine hydrochloride (GuHCl) and to unfold cooperatively. However, their stabilities toward GuHCl, propensity to self‐aggregate and structural specificity differed. The two‐glycine variant of the second‐generation series demonstrated the highest stability and most native‐like character of all the mononeric TASPs in both the first‐ and second‐generation series. The structural specificity of this two glycine variant is comparable to that of other known native‐like de novo proteins. Molecular dynamics simulations showed that the two‐glycine variant contains helices that are tilted with respect to the cavitand template and may account for its unique properties.
Synthesis and Photoinduced Intramolecular Processes of Fulleropyrrolidine–Oligothienylenevinylene–Ferrocene Triads
Authors: Oswald Frédéric , Islam D.‐M. Shafiqul , Araki Yasuyuki , Troiani Vincent , de la Cruz Pilar , Moreno Andrés , Ito Osamu , Langa Fernando 
Published: February 2007

AbstractTwo new triads based on N‐methylfulleropyrolidine, oligothienylenevinylenes (nTV) and ferrocene (Fc), namely C60‐nTV‐Fc (n=2, 4) have been synthesized. A HOMO–LUMO gap as low as 1.09–1.11 eV was experimentally determined by cyclic voltammetry. In both polar and nonpolar solvents, photoinduced charge‐separation (CS) processes in C60‐nTV‐Fc predominantly take place from the singlet excited states of C60 and nTV; this result was indicated by steady and time‐resolved emission spectroscopy. In the case of C60‐4TV‐Fc, the CS state was indicated by the nanosecond transient absorption spectra. In C60‐2TV‐Fc, although the CS process was also confirmed by the fluorescence quenching in nonpolar and polar solvents, the lifetimes of the CS states were shorter than those of C60‐4TV‐Fc. It was revealed that the introduction of Fc donor moiety at the end of the longer nTV chain in the C60‐nTV dyad systems effectively increases the CS efficiency and the lifetimes of CS states.