bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
Authors: Etemad Asieh , Tanaka Yosuke , Wang Shuo , Slae Mordechai , Sultan Mutaz , Elpeleg Orly , Hirokawa Nobutaka 
Published: February 2025

Abstract
As a common cause of liver cirrhosis, metabolic dysfunction-associated steatohepatitis (MASH) is regarded as a target of therapeutic intervention. However, a successful therapy has not yet been found, partly because the molecular pathogenesis is largely elusive. Here we show that KIF12 kinesin suppresses MASH development by accelerating the breakdown of two lipid biosynthesis enzymes, acetyl-CoA carboxylase 1 (ACC1) and pyruvate carboxylase (PC), in hepatocytes. We report three familial early-onset liver cirrhosis pedigrees with homozygous KIF12 mutations, accompanying MASH-like steatosis and cholestasis. The mouse genetic model carrying the corresponding Kif12 nonsense mutation faithfully reproduced the phenotypes as early as between 8 and 10 weeks of age. Furthermore, KIF12-deficient HepG2 cells exhibited significant steatosis, which was ameliorated by overexpressing a proline-rich domain (PRD) of KIF12. We found that KIF12-PRD promotes the degradation of ACC1 and PC, and this effect is likely to be through its direct interaction with these enzymes. Interestingly, KIF12 enhanced the ubiquitination of ACC1 by the E3 ligase COP1 and colocalized with these proteins as seen by super-resolution microscopy imaging. These data propose a role for KIF12 in suppressing MASH by accelerating turnover of lipogenic enzymes.
Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs
Authors: Peters Niklas , Kanngießer Sibylle , Pajonk Oliver , Salazar Claros Rafael , Hubbe Petra , Mogk Axel , Schuck Sebastian 
Published: February 2025

Abstract
One way cells control the speed and specificity of protein degradation is by regulating the activity of ubiquitin ligases. Upon proteotoxic stress in yeast, the intrinsically disordered protein Roq1 binds the ubiquitin ligase Ubr1 as a pseudosubstrate, thereby modulating the degradation of substrates of the N-degron pathway and promoting the elimination of misfolded proteins. The mechanism underlying this reprograming of Ubr1 is unknown. Here, we show that Roq1 controls Ubr1 by means of two cooperating multifunctional motifs. The N-terminal arginine and a short hydrophobic motif of Roq1 interact with Ubr1 as part of a heterobivalent binding mechanism. Via its N-terminal arginine, Roq1 regulates the ubiquitination of various N-degron substrates and folded proteins. Via its hydrophobic motif, Roq1 accelerates the ubiquitination of misfolded proteins. These findings reveal how a small, intrinsically disordered protein with a simple architecture engages parallel channels of communication to reprogram a functionally complex ubiquitin ligase.
Arginine: at the crossroads of nitrogen metabolism
Authors: Fung Tak Shun , Ryu Keun Woo , Thompson Craig B 
Published: February 2025

Abstract
L-arginine is the most nitrogen-rich amino acid, acting as a key precursor for the synthesis of nitrogen-containing metabolites and an essential intermediate in the clearance of excess nitrogen. Arginine’s side chain possesses a guanidino group which has unique biochemical properties, and plays a primary role in nitrogen excretion (urea), cellular signaling (nitric oxide) and energy buffering (phosphocreatine). The post-translational modification of protein-incorporated arginine by guanidino-group methylation also contributes to epigenetic gene control. Most human cells do not synthesize sufficient arginine to meet demand and are dependent on exogenous arginine. Thus, dietary arginine plays an important role in maintaining health, particularly upon physiologic stress. How cells adapt to changes in extracellular arginine availability is unclear, mostly because nearly all tissue culture media are supplemented with supraphysiologic levels of arginine. Evidence is emerging that arginine-deficiency can influence disease progression. Here, we review new insights into the importance of arginine as a metabolite, emphasizing the central role of mitochondria in arginine synthesis/catabolism and the recent discovery that arginine can act as a signaling molecule regulating gene expression and organelle dynamics.
Sensorineural Hearing Loss after Chemoradiotherapy with High-Dose Cisplatin in Patients with Head and Neck Cancer
Authors: Kitoh Ryosuke , Hirose Kota , Kasuga Mariko , Hori Kentaro , Yokota Yoh , Iwasa Yoh-ichiro , Takumi Yutaka 
Published: February 2025

Abstract
Objective To investigate sensorineural hearing loss in patients with head and neck cancer receiving chemoradiotherapy (CRT) with a standard regimen of high-dose cisplatin, focusing on the acute changes before and after CRT with high-dose cisplatin (CDDP).
Materials and Methods A total of, 135 cases of head and neck cancer treated with high-dose cisplatin-based CRT between 2014 and 2023 were included in this retrospective study. The hearing threshold shifts at each frequency before and after each CDDP dose were used as an indicator to assess hearing impairment.
Results The CRT-induced hearing threshold shift was greater at frequencies >4,000 Hz, with a threshold increment of ∼10 dB at 4,000 Hz and 20 dB at 8,000 Hz. The threshold after each course of CDDP was elevated at one week after CDDP administration, and the changes in the thresholds from one week after administration to just before the subsequent course were small. Total CDDP dose, radiation dose to the cochlea, and mean pretreatment hearing thresholds were identified as significant factors influencing the increase in hearing thresholds at 8,000 Hz.
Conclusion In patients with head and neck cancer receiving CRT with high-dose cisplatin, threshold increment was predominantly observed at frequencies >4,000 Hz, as previously reported. The threshold increment occurred immediately after CDDP administration, which might be relevant when considering the timing of future interventions.
The embodied, entangled self and complicity in the neoliberal academy
Authors: Barthwal-Datta Monika 
Published: February 2025

Abstract
In The Self, and Other Stories: Being, Knowing, Writing, Laura Shepherd illuminates the embodied and entangled nature of knowing the self, and the self as a ‘knowing subject’ in the neoliberal, violent, and exclusionary academy. Here, I explore some of the ways in which such embodiment and entanglements of the self in the academy are made (in)visible in and through the stories and storytelling in Laura’s book. I focus particularly on Laura’s recounting of her complicity with the institution, for instance through her internalization of the individualized responsibility for ‘success’ in the neoliberal academy towards hyper-productivity, and her embodying and enacting of the ‘serious’ ‘knowing’ subject in academia. Noting the significance of such stories for the demystification of ‘success’ as an academic, and the cost such success may extract from the self, I consider how there is still room left to reflect on the implications of such complicity by relatively privileged bodies, for those bodies positioned differently and differentially in the neoliberal university.
Transient temperature measurement of electron beam bombarded stainless steel via nanosecond two-color pyrometry
Authors: Watson T. M. , Mockert J. T. , Neuber A. A. , Dickens J. C. 
Published: February 2025

A two-color pyrometer is presented that enables detection of a temperature rise with temporal resolution of 17.5 ns. It is geared toward extreme environments where fast electrical electron pulses or currents may push the temperature of a metal surface to melt on a 100 ns time scale. The developed pyrometer, which utilizes an internal gain of 100x, has been tested for SS304 surfaces subjected to an intense electron beam in vacuum. The two-color pyrometer is calibrated using a quasi-calibration method by heating a graphite disk and measuring this temperature with a FLIR TG297 thermal camera. The quasi-calibration method supports the pyrometer to be within 3% accuracy of absolute temperature. The measured temporal temperature profile of the SS304 surface was derived from the pyrometer output data through a detailed gray-body analysis utilizing empirical emissivity data from publicly available literature.
High-power and narrow-linewidth laser on thin-film lithium niobate enabled by photonic wire bonding
Authors: Franken Cornelis A. A. , Cheng Rebecca , Powell Keith , Kyriazidis Georgios , Rosborough Victoria , Musolf Juergen , Shah Maximilian , Barton David R. , Hills Gage , Johansson Leif , Boller Klaus-J. , Lončar Marko 
Published: February 2025

Thin-film lithium niobate (TFLN) has emerged as a promising platform for the realization of high-performance chip-scale optical systems, spanning a range of applications from optical communications to microwave photonics. Such applications rely on the integration of multiple components onto a single platform. However, while many of these components have already been demonstrated on the TFLN platform, to date, a major bottleneck of the platform is the existence of a tunable, high-power, and narrow-linewidth on-chip laser. Here, we address this problem using photonic wire bonding to integrate optical amplifiers with a TFLN feedback circuit. We demonstrate an extended cavity diode laser with an excellent side mode suppression ratio exceeding 60 dB and a wide wavelength tunability over 43 nm. At higher currents, the laser produces a high maximum on-chip power of 76.2 mW while maintaining 51 dB side mode suppression. The laser frequency stability over short timescales shows an ultra-narrow intrinsic linewidth of 550 Hz. Long-term recordings indicate a high passive stability of the photonic wire bonded laser with 58 hours of mode-hop-free operation, with a trend in the frequency drift of only 4.4 MHz/h. This work verifies photonic wire bonding as a viable integration solution for high performance on-chip lasers, opening the path to system level upscaling and Watt-level output powers.
Ultrafast optical and passive acoustic mapping characterization of nanoscale cavitation nuclei based on gas vesicle proteins
Authors: Smith Cameron A. B. , Bar-Zion Avinoam , Wu Qiang , Malounda Dina , Bau Luca , Stride Eleanor , Shapiro Mikhail G. , Coussios Constantin C. 
Published: February 2025

Genetically encodable gas-filled particles, known as gas vesicles (GVs), have shown promise as a biomolecular contrast agent for ultrasound imaging and have the potential to be used as cavitation nuclei for ultrasound therapy. In this study, we used passive acoustic mapping techniques to characterize GV-seeded cavitation, utilizing 0.5 and 1.6 MHz ultrasound insonation over peak rarefactional pressures ranging from 100 to 2200 kPa. We found that GVs produce cavitation for the duration of the first applied pulse, up to at least 5000 cycles, but that bubble activity diminishes rapidly over subsequent pulses. At 0.5 MHz, the frequency content of cavitation emissions was predominantly broadband in nature, while at 1.6 MHz, narrowband content at harmonics of the main excitation frequency dominated. Simulations and high-speed camera imaging suggest that the received cavitation emissions come not from individual GVs but instead from the coalescence of GV-released gas into larger bubbles during the applied ultrasound pulse. These results will aid the future development of GVs as cavitation nuclei in ultrasound therapy.
Stimulated Brillouin scattering in a non-suspended ultra-low-loss thick-SOI platform
Authors: Ye Kaixuan , Keloth Akshay , Marin Yisbel E. , Cherchi Matteo , Aalto Timo , Marpaung David 
Published: February 2025

Silicon photonics, with its CMOS compatibility and high integration density, has enabled a wide range of novel applications. Harnessing stimulated Brillouin scattering (SBS), an optomechanic interaction between optical and gigahertz acoustic waves, in silicon-on-insulator (SOI) platforms attracts great interest for its potential in narrow-linewidth lasers and microwave photonics. However, the poor optoacoustic overlap in silicon nanowires on conventional SOI platforms has previously restricted the observation of SBS signals to suspended silicon waveguide structures. In this work, we report, for the first time, the SBS response in a non-suspended ultra-low-loss thick-SOI waveguide platform. The backward SBS process in this 3 μm thick SOI platform is enabled by a leaky acoustic mode that coexists with the optical mode in the waveguide core, resulting in an enhanced optoacoustic overlap. We measured Brillouin gain coefficients of 2.5 and 1.9 m−1 W−1 at 37.6 GHz for the rib and strip waveguides, respectively. This work paves the way for Brillouin-based applications in non-suspended ultra-low-loss silicon photonics systems.
Joint approximate diagonalization approach to quasiparticle self-consistent GW calculations
Authors: Duchemin Ivan , Blase Xavier 
Published: February 2025

We introduce an alternative route to quasiparticle self-consistent GW calculations (qsGW) on the basis of a joint approximate diagonalization of the one-body GW Green’s functions G(εnQP) taken at the input quasiparticle energies. Such an approach allows working with the full dynamical self-energy, without approximating the latter by a symmetrized static form as in the standard qsGW scheme. Calculations on the GW100 molecular test set lead, nevertheless, to a good agreement, at the 60 meV mean-absolute-error accuracy on the ionization potential, with respect to the conventional qsGW approach. We show further that constructing the density matrix from the full Green’s function as in the fully self-consistent scGW scheme, and not from the occupied quasiparticle one-body orbitals, allows obtaining a scheme intermediate between the qsGW and scGW approaches, closer to coupled-cluster reference values.
Learner pragmatics in English-medium‑instruction courses at university
Authors: Martí Otilia , Guzmán-Alcón Irene 
Published: February 2025

Abstract
This paper critically reviews pragmatic-oriented investigations of English-medium instruction (EMI) courses in
tertiary education. Analyses on potential gains in pragmatic competence, classroom interaction, and e-politeness define some of
the lines of research identified. Speech acts like requests and opinions (e.g., Taguchi,
2012, 2014) or directives (e.g., Smit,
2010) are still the main foci of interest, along with pragmatic markers (e.g., Ament et al., 2018) or openings and closings (e.g., Codina-Espurz
& Salazar-Campillo, 2019). A more holistic perspective has also been adopted to examine functional adequacy in
writing (e.g., Herraiz-Martinez & Alcón-Soler, 2019). Strengths and limitations of
studies conducted in the EMI context are discussed and, from this, a research agenda is put forward. Lastly, future investigators
are encouraged to explore the complex interplay between external (e.g., target language contact) and internal factors (e.g.,
proficiency, motivation, or willingness to communicate) which may have an impact on learner pragmatics.
Electromagnetic form factors of hyperons in the timelike region: A short review
Authors: Dai Ling-Yun , Haidenbauer Johann , Meißner Ulf-G. 
Published: February 2025

Abstract
We review recent experimental and theoretical results for the electromagnetic form factors of hyperons (Y) in the timelike region, accessible in the reactions e
+
e
- →
Y

Y. Specifically, we focus on the final states ΛΛ, ΛΣ0/Σ
0Λ, ΣΣ, ΞΞ, and ΩΩ. The Λ
cΛc system is also discussed.
A method for measuring individual ion density in an Ar/He mixture inductively coupled plasma
Authors: Son Jin-Ung , Lee Moo-Hyun , Kim Min-Seok , Jung Jiwon , Seo Beom-Jun , Kim Ju Ho , Chung Chin-Wook 
Published: February 2025

Abstract
A method for measuring individual ion density and for measuring radial distribution is developed in an argon/helium mixture inductively coupled plasma using the floating harmonic method (FHM) and the electron energy probability function (EEPF) measurement. In order to measure the ion density, the ion saturation current is measured using the FHM, and the electron temperature and electron density are obtained from the EEPF measurement. In addition, plasma quasi-neutrality, ion acoustic wave dispersion relation, and ion saturation current formula are used to obtain the ion density. Ion density is compared for the case of using the common Bohm velocity and for the case of using the individual Bohm velocity. Under various conditions, increasing power results in higher density of both argon and helium ion, while argon ion density increase and helium ion density decreases with pressure. With increasing argon ratio and pressure, electron density increases, but electron temperature deceases. Consequently, fewer electrons are available to ionize He, leading to a reduction in helium ion density. The measured radial distributions of argon and helium ion at 5 mTorr reveal that the argon ion distribution exhibits a center-high distribution, whereas the helium ion distribution is relatively uniform. Keywords : Inductively coupled plasma, Ar/He mixture, ion density, floating harmonic method, electron energy probability function&#xD;
Schwarzschild black hole in galaxies surrounded by a dark matter halo
Authors: Al-Badawi Ahmad , Shaymatov Sanjar , Sekhmani Yassine 
Published: February 2025

Abstract
In this paper, we derive a novel Schwarzschild-like black hole (BH) solution describing a static and asymptotically flat BH surrounded by a dark matter (DM) halo with a Dehnen-type density distribution in the surrounding environment. We investigate the properties of the obtained BH by studying the curvature properties and energy conditions in Einstein gravity. Furthermore, we explore the features of a novel Schwarzschild-like BH embedded in a DM halo with Dehnen-type density profile by analyzing the timelike geodesics of particles along with BH observable properties.
Quantum anomalous Hall effect in twisted bilayer graphene
Authors: Wang Wen-Xiao , Liu Yi-Wen , He Lin 
Published: February 2025

Abstract
Recent advancements in two-dimensional van der Waals moirématerials have unveiled the captivating landscape of moiréphysics. In twisted bilayer graphene (TBG) at ‘magic angles’, strong electronic correlations give rise to a diverse array of exotic physical phenomena, including correlated insulating states, superconductivity, magnetism, topological phases, and the quantum anomalous Hall (QAH) effect. Notably, the QAH effect demonstrates substantial promise for applications in electronic and quantum computing devices with low power consumption. This article focuses on the latest developments surrounding the QAH effect in magic-angle TBG. It provides a comprehensive analysis of magnetism and topology--two crucial factors in engineering the QAH effect within magic-angle TBG. Additionally, it offers a detailed overview of the experimental realization of the QAH effect in moiré superlattices. Furthermore, this review highlights the underlying mechanisms driving these exotic phases in moiré materials, contributing to a deeper understanding of strongly interacting quantum systems and facilitating the manipulation of new material properties to achieve novel quantum states.
Manipulation of Vortex Array via a Magnetism-Tunable Spin-Polarized Scanning Tunnelling Microscopy
Authors: Xia Bing , Chen Hong-Yuan , Zheng Jian , Yang Bo , Cai Jie , Zhang Yi , Yang Yi , Yang Hao , Guan Dan-Dan , Liu Xiao-Xue , Liu Liang , Li Yao-Yi , Wang Shi-Yong , Liu Can-Hua , Zheng Hao , Jia Jin-Feng 
Published: February 2025

Abstract
Manipulating and braiding Majorana zero modes (MZM) is a critical step toward realizing topological quantum computing. The primary challenge is controlling the vortex, which hosts the MZM, within a superconducting film in a spatially precise manner. To address this, we developed a magnetic force-based vortex control technology using the STM system with a self-designed 4-electrode piezo-scanner tube and investigated vortex manipulation on the NbSe2 superconducting film. We employed ferromagnetic tips to control the movement of vortex array induced by the tip's remanent magnetism. A magnetic core solenoid device was integrated into the STM system, and a strong magnetic tip demagnetization technique was developed, providing a viable technical solution for further enabling single vortex manipulation.
Utilization of River Snail Shells as Formaldehyde Absorbents
Authors: Tan Xiaofeng , Tian Chao , Li Wenyi , Yu Xinrui 
Published: February 2025

Abstract
This study addresses aquaculture waste management challenges by proposing a pollution control and resource utilization strategy through the calcination of discarded river snail shells (RSC) at different temperatures for formaldehyde absorption. The findings indicate that calcining RSC at 900°C transforms the material into calcium oxide with a porous structure, resulting in excellent adsorption capacity. Formaldehyde adsorption tests show that RSC calcined at both 900°C and 1000°C perform well in adsorption, with the 900°C calcined RSC demonstrating optimal effectiveness considering both economic and energy-saving factors. This approach presents an innovative solution for enhancing indoor air quality by incorporating shell powder into surface coatings.
Moisture Absorbing Properties of Alkylbenzenes with Experiment and Molecular Dynamics Simulation Calculation
Authors: Liu Zhifeng , Zhou Shangming , Liao Jianping , Gao Fan , Chen Yufei , Zhu Zhiping 
Published: February 2025

Abstract
The presence of moisture accelerates the aging of insulating oil thus greatly reducing the insulating performance. In this study, in order to investigate their absorb moisture characteristics, comparison experiments and molecular dynamics simulation calculations at 1wt% oil-water mixing were carried out for the alkylbenzene insulating oil, mineral oil and vegetable oil. The experiment results show that vegetable oil has the strongest moisture absorption ability, alkylbenzene insulating oil is the second, and mineral oil is the weakest at temperature 15-45°C and relative humidity 90%, as the temperature rises from 15°C to 30°C, the growth of the moisture absorption rate is significant, but as temperature rises from 30°C to 45°C the increase tendency is smaller; the results of molecular dynamics simulation the show that with the increase of temperature, the molecular motion is intensified, the interaction energy decreases, and the free volume and diffusion coefficient increase. These results help to understand the moisture absorption mechanism of alkylbenzene insulating oil and provide a theoretical basis for its storage and use.