bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention
Authors: Bappi Mehedi Hasan , Mia Md. Nayem , Ansari Siddique Akber , Ansari Irfan Aamer , Prottay Abdullah Al Shamsh , Akbor Md. Showkoth , El‐Nashar Heba A. S. , El‐Shazly Mohamed , Mubarak Mohammad S. , Torequl Islam Muhammad 
Published: February 2024

AbstractQuercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health‐promoting effects. This study aimed to examine the effects of quercetin (QR) and sclareol (SCL) on the thiopental sodium (TS)‐induced sleeping and forced swimming test (FST) mouse models. SCL (1, 5, and 10 mg/kg, p.o.) or QR (50 mg/kg, p.o.) and/or diazepam (DZP) (3 mg/kg, i.p.) were employed. After 30 min of TS induction, individual or combined effects on the animals were checked. In the FST test, the animals were subjected to forced swimming after 30 min of administration of the test and/or controls for 5 min. In this case, immobility time was measured. In silico studies were conducted to evaluate the involvement of GABA receptors. SCL (5 and 10 mg/kg) significantly increased the latency and decreased sleeping time compared to the control in the TS‐induced sleeping time study. DZP (3 mg/kg) showed a sedative‐like effect in animals in both sleeping and FST studies. QR (50 mg/kg) exhibited a similar pattern of activity as SCL. However, its effects were more prominent than those of SCL groups. SCL (10 mg/kg) altered the DZP‐3‐mediated effects. SCL‐10 co‐treated with QR‐50 significantly (p < 0.05) increased the latency and decreased sleep time and immobility time, suggesting possible synergistic antidepressant‐like effects. In silico studies revealed that SCL and QR demonstrated better binding affinities with GABAA receptor, especially α2, α3, and α5 subunits. Both compounds also exhibited good ADMET and drug‐like properties. In animal studies, the both compounds worked synergistically to provide antidepressant‐like effects in a slightly different fashion. As a conclusion, the combined administration of SCL and QR may be used in upcoming neurological clinical trials, according to in vivo and in silico findings. However, additional investigation is necessary to verify this behavior and clarify the potential mechanism of action.
Executive's environmental background and sustainable development: Evidence from substantial green innovation
Authors: Luo Kun , Zhang Ke 
Published: February 2024

AbstractExecutive as decision makers influence the corporate sustainable development, especially their environmental experiences will be internalized in corporate management to promote the development of corporate substantive green innovation. This article empirically explores the impact of executive's environmental background on corporate substantive green innovation based on the data of Chinese A‐share listed companies from 2011 to 2019, and finds that executive's environmental background is conducive to promoting corporate substantive green innovation, which is achieved by obtaining government environmental subsidies and attracting green investors. And further research has revealed that executive's environmental background has a more significant impact on corporate substantive green innovation with higher level of environmental regulations, quality of corporate governance and environmental awareness of executives. The findings of this article not only provides a new perspective for companies to choose a green development path and enhance substantive green innovation, but also provides empirical evidence for companies to promote green transformation and introduce executive with environmental background.
Modulating surface functional groups in carbon dots for enhanced inhibition of β‐amyloid aggregation
Authors: Yan Kailong , Li Chunlan , Zhu Xu , Zhang Yintang , Xiao Guoqing , Xu Maotian 
Published: February 2024

AbstractGaining a profound understanding of carbon dots (CDs) structure and their potential to inhibit β‐amyloid (Aβ) aggregation holds significant importance in the quest for Alzheimer's disease (AD) prevention and treatment. Herein, CDs with varying structures were synthesized by adjusting the molar ratio of citric acid (CA) and ethylenediamine (EDA). Transmission electron microscopy (TEM) was used to characterize their size and morphology. Fourier transform infrared spectroscopy (FTIR) and X‐ray photoelectron spectroscopy (XPS) were applied to study their structure. Optical properties were analyzed through Ultraviolet (UV) spectroscopy absorption and fluorescence spectroscopy. The inhibitory effect of CDs on Aβ1–42 aggregation was explored using circular dichroism and atomic force microscopy (AFM). The results highlighted the substantial influence of the CA to EDA molar ratio on the surface structure of CDs, subsequently impacting their optical properties and efficacy in inhibiting Aβ1–42 aggregation. With increasing EDA content, CDs exhibited a rise in the number of amino functional groups while experiencing a reduction in carboxyl groups. CDs possessing more amino functional groups effectively induced alterations in the initial conformation of Aβ1–42, leading to a significant inhibition of Aβ1–42 aggregation.
Hydrothermal Synthesis, Formation Mechanism and Photocatalytic Activity of SnO2/BiOBr
Authors: Xu Tiantian , Gao Zhanyao , Jin Yabin , Song Wenhan , Liu Bo , Yao Binghua 
Published: February 2024

AbstractSnO2/BiOBr photocatalytic materials were successfully synthesized by hydrothermal method with BiOBr as the precursor. X‐ray diffraction studies confirmed that BiOBr and SnO2 were successfully combined. After characterization, we proposed a possible formation mechanism for SnO2/BiOBr. The degradation experiment showed that the degradation rate of norfloxacin using SnO2/BiOB‐4 reached 85.9 %, which was approximately 50 and 65 percentage points higher than that of pure BiOBr and SnO2, respectively. The reaction rate was 4.3 times that of BiOBr. Based on the analysis of the degradation mechanism, the improved photocatalytic performance may be attributed to the optimized energy band structure resulting from the combination of the two monomers. This promotes the effective separation of photogenerated electrons and holes, leading to the generation of more active substances such as ⋅O2− and h+. As a result, the oxidation capacity is enhanced.
Achieving Cross Time‐Domain Multiplexed Signal Cascade and Cancer Exosomes Identification by Bridging Long Lifetime Phosphor to NIR‐II Lanthanide Energy Transfer
Authors: Li Haiyan , Bai Junjie , Chen Yafei , Du Cheng , Chen Mingli , Wang Jianhua 
Published: February 2024

AbstractDesigning lanthanide luminescence lifetime sensors in the second near‐infrared (NIR‐II) window holds great potentials for physiological studies. However, the single lifetime signal is confined to one or two orders of magnitude of signal variation, which limits the sensitivity of lifetime probes. In this study, a lifetime cascade system, i.e., ZGO:Mn, Eu‐DNA‐1/TCPP‐PEI70K@Yb‐AptEpCAM, with a variety of signals (τm, τn, τµ, τm/τn and τm/τµ) is constructed for exosome identification using time‐domain multiplexing. The sensitized ligand TCPP acts as both target‐modulated switch and a bridge for connecting long lifetime ZGO:Mn, Eu‐DNA‐1 emitter to lanthanide Yb3+. This drives successive dual‐path energy transfer and forms two D(donor)‐A(acceptor) pairs. The lifetime variation is dominantly modulated by arranging TCPP as energy intermediate relay to covert milliseconds to nanoseconds to microseconds. It enables a broad lifetime range of six orders of magnitude. The presence of exosome specifically recognizes aptamers on TCPP‐PEI70K@Yb‐AptEpCAM to impede D‐A pairs and reverse multiplexed response signals of the lifetime cascade system. The ratio lifetime signals τm/τn and τm/τµ achieve prominent exosome quantification and exosome type differentiation attributed to signal amplification. The cascade system relying on lifetime criteria can realize precise quantization and provide an effective strategy for subsequent physiological study.
Tailoring Interfacial Electric Field by Gold Nanoparticles Enable Electrocatalytic Lithium Polysulfides Conversion for Lithium‐Sulfur Batteries
Authors: Zou Rong , Zhang Jie , Zheng Yawen , Li Jinling , Liu Wenwu , Ran Fen 
Published: February 2024

AbstractAlthough lithium‐sulfur batteries (LSBs) are considered as the promising next rechargeable storage system ascribing to their decent specific capacity of inorganic sulfur, the development is partially impeded by inferior electronic conductivity, severe shuttle effect, and large volume variation. To tackle the issues above, a great deal of effort is made on sulfur‐containing polymer (SCP) that shows better electrochemical performance. Nevertheless, sluggish conversion of lithium polysulfides (LiPSs) obstructs battery performance yet. Herein, electrocatalytic LiPSs with full conversion by tailoring the interfacial electric field are discovered based on gold nanoparticles (AuNPs) anchored on sulfurized polyaniline (SPANI). A downhill path of Gibbs free energy from organosulfur polymer to intermediate product means more spontaneously and favorable for full conversion, as the significant enhancement of electron density of state in the vicinity of the HOMO level for the AuNPs increase the electron transition probability rate. This composite delivers satisfactory electrochemical performance, especially increased rate capacity of >300 mAh g−1. Furthermore, catalyst mechanism on molecule level is proposed that AuNPsdominate chemical enhancement and higher electron delocalizablility betweenAuNPs and LiPSs molecules. These results can erect a promising strategy for enhancing lithium polysulfides full conversion.
The Art of Nanoparticle Design: Unconventional Morphologies for Advancing Luminescent Technologies
Authors: Xu Hanyu , Dai Mengmeng , Fu Zuoling 
Published: February 2024

AbstractThe advanced design of rare‐earth‐doped (RE‐doped) fluoride nanoparticles has expanded their applications ranging from anticounterfeiting luminescence and contactless temperature measurement to photodynamic therapy. Several recent studies have focused on developing rare morphologies of RE‐doped nanoparticles. Distinct physical morphologies of RE‐doped fluoride materials set them apart from contemporary nanoparticles. Every unusual structure holds the potential to dramatically improve the physical performance of nanoparticles, resulting in a remarkable revolution and a wide range of applications. This comprehensive review serves as a guide offering insights into various uniquely structured nanoparticles, including hollow, dumbbell‐shaped, and peasecod‐like forms. It aims to cater to both novices and experts interested in exploring the morphological transformations of nanoparticles. Discovering new energy transfer pathways and enhancing the optical application performance have been long‐term challenges for which new solutions can be found in old papers. In the future, nanoparticle morphology design is expected to involve more refined microphysical methods and chemically‐induced syntheses. Targeted modification of nanoparticle morphology and the aggregation of nanoparticles of various shapes can provide the advantages of different structures and enhance the universality of nanoparticles.
Experimental study on fundamental frequency and human‐induced vibration characteristics of light steel foam concrete composite floor
Authors: Xu Qiang , Xu Liping , Meng Linghui , Liu Yuyang , Bai Yinhui 
Published: February 2024

SummaryIn order to study the dynamic characteristics and human‐induced vibration response of light steel foamed concrete composite floor (LCSF), the vibration characteristics of 4.2 m × 5 m LCSF model were tested under the condition of opposite side support, and the natural vibration frequency of LCSF was obtained. The orthogonal anisotropic elastic plate and the simulated beam element were used, respectively, to compute the natural vibration frequency of the LCSF, and the estimated findings were compared with those obtained from measurements. The discrepancy between the calculated results and the measured results of the approximate beam element using the natural vibration frequency calculation technique is around 13%, but the error for the plate element using the calculated results and the tested results is about 23%. To examine the floor's vibration response under the factors of step frequency, walking path, pedestrian density, and load distribution, the LCSF underwent a human‐induced vibration test. The test results show that the fundamental frequency of the LCSF specimen is about 11 Hz, which can meet the requirements of the specification. However, the vibration response of the LCSF specimen under different conditions of pedestrian load is significantly different. With the acceleration of step frequency and the increase and concentration of load, the floor's vibration response becomes more visible. In the route test, it is established that LCSF has the attribute of a unidirectional plate. The natural vibration frequency of similar floor slab can be calculated by the method of simulating the natural vibration frequency of beam element. The findings can serve as a guide for LCSF research and implementation.
Rebuttal to “(2943) Proposal to conserve Selaginella, nom. cons., (Selaginellaceae) with a conserved type”: An unwarranted and disruptive idea
Authors: Valdespino Iván A. , Korall Petra , Weststrand Stina , López Christian A. , Tang Jun‐Yong , Shalimov Alexander , Zhang Xian‐Chun 
Published: February 2024

AbstractA rebuttal to the proposal to conserve Selaginella, nom. cons., with a conserved type is submitted. We further discuss why this proposal is unwarranted and disruptive to nomenclatural stability as is the intention to split Selaginella since potentially segregated genera fail to reconcile monophyly and taxonomic diagnosability. Accordingly, we recommend the rejection of the Proposal (2943) and not to follow the dismembering of Selaginella.
STAT3 phosphorylation inhibitor Bt354 exhibits anti‐neoplastic activity in glioblastoma multiforme cells
Authors: Chiang Yi‐Chun , Selvam Padhmavathi , Liu You‐Xuan , Shih Po‐Chang , Chen Nan‐Fu , Kuo Hsiao‐Mei , Lin Hugo You‐Hsien , Wen Zhi‐Hong , Chen Wu‐Fu 
Published: February 2024

AbstractThe high mortality rate of glioblastoma multiforme (GBM), a lethal primary brain tumor, is attributable to postsurgical recurrence. STAT3, an oncogenic protein, is a signal transducer and transcription activator encourages cancer cell migration and proliferation, which results in resistance to therapy. STAT3 inhibition reduces cancer metastasis and improves patient prognosis. Bt354, a small molecule STAT inhibitor, exhibits significant cytotoxic and anti‐proliferative activities against certain cancer types. Here, we demonstrated that exposure of GBM cells (U87 MG) to Bt354 had a significant, concentration‐dependent growth suppression. Bt354 also induced apoptosis and downregulated the expression of the epithelial‐mesenchymal transition genes. Therefore, this study suggests the potential of Bt354 for treating GBM owing to its ability to induce cytotoxicity.
Long‐term exposure of Allonais inaequalis to a mixture of antibiotics in freshwater and synthetic wastewater matrices: Reproduction, recovery, and swimming responses
Authors: Castro Gleyson B. , Alexandre David S. , Bernegossi Aline C. , Bezerra Yohanna A. F. , Fonsêca Mateus C. , Zaiat Marcelo , Corbi Juliano J. 
Published: February 2024

AbstractAntibiotics from sulfonamide, fluoroquinolone, and diaminopyrimidine classes are widely used in human and veterinary medicine, and their combined occurrence in the aquatic environment is increasing around the world. In parallel, the understanding of how mixtures of these compounds affect non‐target species from tropical freshwaters is scarce. Thus, this work aimed to study the long‐term reproductive, recovery, and swimming effects of mixtures of 12 antibiotics from three different classes (up to 10 μg L−1) added to freshwater (FWM) and synthetic wastewater (SWM) matrices on freshwater worm Allonais inaequalis. Results revealed that at the reproduction level, the exposure to antibiotics in the SWM matrix does not cause a significant toxic effect on species after 10 days. On the other hand, exposures to initial dose mixtures (10 μg L−1 each) in FWM caused a significant reduction of offspring by 19.2%. In addition, recovery bioassays (10 days in an antibiotic‐free environment) suggested that A. inaequalis has reduced offspring production due to previous exposure to antibiotic mixtures in both matrices. Furthermore, despite slight variation in swimming speed over treatments, no significant differences were pointed out. Regarding antibiotics in the water matrices after 10‐day exposures, the highest concentrations were up to 2.7, 7.8, and 4.2 μg L−1 for antibiotics from sulfonamide, fluoroquinolone, and diaminopyrimidine classes, respectively. These findings suggest that a species positioned between primary producers and secondary consumers may experience late reproductive damage even in an antibiotic‐free zone, after previous 10‐day exposure to antibiotic mixtures.Practitioner Points

A mixture of sulfonamide, fluoroquinolone, and diaminopyrimidine antibiotics in freshwater affects the offspring production of A. inaequalis after 10 days.
After the 10‐day antibiotic exposure, the reproduction of A. inaequalis remains affected in an antibiotic‐free environment over the recovery period.
The swimming speed of the worms does not change after 10 days of exposure to the antibiotic mixture.
The concentration of dissolved solids can limit the natural degradation of sulfonamide, fluoroquinolone, and diaminopyrimidine antibiotics in the aquatic environment.
Effects of botulinum toxin in two indicators of loss of domain and hernia size among patients with large ventral hernias
Authors: Espinosa‐de‐los‐Monteros Antonio , Meza‐Medina Carlos Azaf , Lopez‐Zamora Zurizaday , Solis‐Reyna Rodrigo Alejandro , Carrillo‐Vidales Javier 
Published: February 2024

AbstractBackgroundIn patients with large ventral hernias, botulinum toxin to external and internal oblique muscles decreases thickness and increases length. We examined the impact of botulinum toxin in the amount of loss of domain according to two ratios and in hernia size.MethodsBetween October 2021 and November 2023, 20 patients with ventral hernias measuring 10 cm or more on the horizontal size underwent the administration of 50 units of botulinum toxin to each external and each internal oblique muscle 4 weeks before their surgery. Incisional hernia volume to peritoneal volume ratio, volume ratio, and hernia size were compared before and 4 weeks after the injection of botulinum toxin. Comparisons between all variables obtained before and after the administration of botulinum toxin were performed using either the paired t‐test or the Wilcoxon signed‐rank test. Pearson correlation coefficient was used to analyze associations between initial conditions and further changes observed after botulinum toxin injection.ResultsWe observed a 42% reduction in muscle amplitude, 16% increase in intra‐abdominal volume, 28% decrease in herniated volume, decreases of 6% in IHV/PV ratio and of 11% in V ratio, 11% reduction of hernia width, and decrease of 10% in rectangular and elliptical hernia areas.ConclusionsIn patients with large ventral hernias, botulinum toxin is associated with reduction of hernia size and decrease in loss of domain, the latter not being significant when less than 10% of the visceral block is herniated.
Race and sex diversity in Canadian academic surgical societies
Authors: Valji Rahim H. , Valji Yasmin , Turner Simon R. 
Published: February 2024

AbstractBackgroundIt is vital for national professional surgical societies to embrace diversity, inclusion, and equity. This study examines race and sex diversity in two Canadian surgical societies.MethodsWebsites of the Canadian Society of Cardiac Surgeons (CSCS) and the Canadian Association of General Surgeons (CAGS) and previous programs of their annual meetings were reviewed. Leadership positions, conference speakers, and award winners were categorized by race and sex.ResultsWhite males made up the largest category of Cardiac Surgery meeting speakers (73/142 [51%]), CAGS committee members (89/198 [45%]), CAGS past presidents (38/43 [88%]), and General Surgery meeting speakers (841/1472 [57%]). Of the 17 members that made up the CSCS board of directors and officers, 8 were White males (47%), 5 were BIPOC males (29%), 3 were White females (18%), and 1 was a BIPOC female (6%). Of the 42 members of the CAGS board of directors and advisory committee, 16 were White males (38%), 5 were BIPOC males (12%), 17 were White females (40%), and 4 were BIPOC females (10%).ConclusionsBIPOC individuals and females are underrepresented in both societies compared to White males. However, in CAGS, improvements in representation can be seen in recent years. It is important that both of these organizations continue to embrace diversity.
Engaging Stakeholders with Platform Labour: The Social Lab Approach
Authors: Tabarés Raúl , Bartolomé Tatiana , García Jorge 
Published: February 2024

AbstractIn recent years, co-creation, experimentation and prototyping has been embraced by public administrations as a means of making policymaking more porous to societal needs. In this regard, social labs have emerged as a way of enabling “safe spaces” where policymakers can obtain new perspectives and approaches from a plethora of stakeholders combining academia, industry, public administration and society as a whole. These labs try to address the complexities, particularities and demands of modern society whilst trying to represent different interests and voices. In this chapter, we offer some insights extracted from a particular experience called the Social Policy Lab (SOPO Lab), which focused on the economic, labour and socio-ethical implications of platform labour in seven European cities (Barcelona, Bologna, Berlin, London, Lisbon, Paris and Tallinn) that are affected by the economic externalities of four digital platforms (Airbnb, Deliveroo, Helpling and Uber). We argue that social labs can provide room to facilitate close collaboration between policymakers and other underrepresented stakeholders, as well as establish synergies between them to counteract the diverse side-effects that digital platforms have in urban settings.
Latent Conflict, Invisible Organisation: Everyday Struggles in Platform Labour
Authors: Altenried Moritz , Niebler Valentin 
Published: February 2024

Abstract The article looks at everyday practices of platform workers and their micro-conflicts with management or customers, which are often disregarded in platform labour literature. Based on empirical research in Berlin, we describe small-scale forms of opposition, conflict and resistance, which often constitute crucial pre-conditions for larger forms of collective action. The article analyses such practices on the platforms Uber, Deliveroo and Helpling. For each platform, we first analyze individual practices (tricking algorithmic management, circumventing regulation) and in a second step describe the more collective approaches (collective blacklisting, algorithm tinkering) arising from it. The article closes with some conclusions and perspectives that can be drawn from these phenomena.