bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and numerical study on the low velocity impact response of plain-woven CFRTP corner region
Authors: Zhao Zhikai , Liu Linghui , Zheng Zhouyu , Chen Xiuhua 
Published: February 2025

Although corner regions exist in many composite structures, such as the wingbox, research in impact engineering is largely focused on the impact performance of plates. Corner regions are subjected to low-velocity impact frequently throughout their life cycle, making it essential to investigate the impact response of these structures to enhance their design and reliability in service. In this paper, the behavior of plain-woven carbon fiber reinforced thermoplastic composites (CFRTP) corner regions under low‐velocity impact loads is studied both numerically and experimentally. Low-velocity impact tests were performed using drop-weight impact equipment at three different energies (15 J, 30 J, and 50 J). Distributed damage and the impacted region of the specimen were determined using high-resolution X-ray CT scans. The experimentally obtained material properties were incorporated into the Viscoelastic User Material (VUMAT) subroutine within ABAQUS to simulate low-velocity impact phenomena. A finite element model (FEA) for plain-woven CFRTP was developed to simulate impact, where six intralaminar damage variables depend on the underlying damage mechanisms, and effective stresses and strains are solved using the backward Euler algorithm. The reliability of FEA was verified through a mesh sensitivity study and model validation. The investigation revealed the relationships of the damage size with the different impact energies. The FEA successfully predicted the force-time and energy-time response, as well as plastic deformation, intralaminar damage, and interlaminar damage.
A critical analysis of the impact of early marriage on girls based on published autobiographies and a contemporary scholarly text – Īḍāḥ al-bayān fī nikāḥ al-ṣibyān
Authors: Mayberry John F 
Published: February 2025

Background This work emerged from a need to better understand the “lived experience” of early marriage for girls and how it should impact on contemporary attitudes in the Muslim community and encourage it to support the international movement with the aim of a minimum common age of 18 years for marriage of young people. Objective To identify from contemporary published literature, including autobiographies and religious texts dealing specifically with early marriage, the effects of early marriage on individuals and to set this as a background to the extensive literature on its medical, psychological and social impact. Participants and setting: The setting is the published words of two women and a man who were involved in early marriages and a commentary on the topic by an Ibadi theologian. Methods The documents were identified through searching a range of databases using various search engines. Texts were then analysed for key terms describing the impact of early marriage and these were then grouped into themes. Findings The extracts raise questions linked to the issue of consent and the role of adult coercion, including physical force and threat of harm. In practice girls are given in marriage by their guardians against their wishes and international conventions on the rights and care of children, as well as that outlined in Qur’an 4 v6. Conclusion Modern Muslim states face a real challenge in implementing 18 as the minimum age for marriage, especially in how to manage opposition to appropriate new legislation from some traditionalist groups.
Associations Between Ecological Determinants and Weight Status Changes Among Children from Vulnerable Populations: Empirical Findings from a National Panel Survey in South Korea
Authors: Park Jiyoung , Ten Hoor Gill A. , Hwang Gahui , Ryu Soorack 
Published: February 2025

Background: Pandemic-related weight gain disproportionately has affected children from socioeconomically disadvantaged backgrounds. However, key determinants of childhood obesity among these vulnerable children remain relatively underexplored. Methods: In a secondary data analysis using a longitudinal dataset, the relationships between child weight status and its individual and environmental influences among vulnerable children were examined based on an ecological model. We analyzed three-point time-series data for 1308 participants from a Korean national panel survey of vulnerable children. Adiposity estimates were calculated using body mass index (BMI) z-scores. Results: The panel regression analysis revealed that 2 factors, namely “lack of adequate sleep time” at the individual level and “suboptimal relationships with childcare teachers” at the interpersonal level, had a significant impact on the BMI z-scores of vulnerable children. Conclusions: It is crucial to develop strategies that ensure sufficient sleep time and to actively involve childcare centers in implementing place-based interventions and initiatives to prevent obesity among vulnerable children. Moreover, it is essential to continue efforts in identifying the significant determinants of childhood obesity among vulnerable populations by considering the major environments in which these children live and grow.
Systematic Development, Validation, and Implementation of a Workshop Module “Suicide Prevention Program” for Pre-University College Teachers
Authors: Borah Kallabi , Jose Tessy Treesa , Nagaraj Anil Kumar Mysore , Bhandary P V 
Published: February 2025

Background: Death by suicide is a global health concern and is one of the top three causes of death among people aged between 15 and 29 years. Teachers are the key professionals in educational institutes to identify symptoms of suicide among students. The present article aimed to develop, validate, and implement a workshop module on the suicide prevention program (SPP). Methods: The workshop module was developed using the “curriculum development for medical education framework”. Subject experts from the psychiatric field validated the module. A total of 72 Pre-University College (PUC) teachers participated in the workshop. A self-structured feedback questionnaire was used to evaluate the participants’ satisfaction. Results: The workshop content areas were identified with a thorough literature review. The workshop module (content, case scenarios for role play, topics for group activities, and diary) was developed in the English language and validated with a content validity index of one. Participants reported high satisfaction with the workshop module. Feedback reported a positive attitude toward suicide prevention. Conclusion: The “Suicide Prevention Program” was developed and validated based on various experts’ suggestions for PUC teachers. It can be implemented in educational institutes. Registration: CTRI registration is done (CTRI/2022/09/045819).
A single injection of neuropeptide QRFP in the lateral hypothalamus decreased food intake
Authors: Zagorácz Olga , Ollmann Tamás , Péczely László , László Kristóf , Kovács Anita , Berta Beáta , Kállai Veronika , Kertes Erika , Vörös Dávid , Dusa Daniella , Szábó Ádám , Lénárd László 
Published: February 2025

Background and aim: Severe eating disorders, such as obesity, bulimia, and anorexia, keep increasing to epidemic proportions worldwide. Understanding of neuropeptides’ role in complex hunger/satiety mechanisms may allow new prospects for treatment and prevention. Pyroglutamylated arginine-phenylalanine-amide peptides (QRFPs) are thought to enhance feeding following the central administration. Methods: In our study, QRFP-26 was delivered into the lateral hypothalamic area of male Wistar rats by direct microinjections, as QRFP-26 expressing neurons and binding sights are densely present in this neural structure. The consumption of liquid food was measured over 60-min. Results: Both doses (100 and 200 ng) significantly decreased food intake compared to the control treatment. Neuropeptide Y Y1R/NPFF (neuropeptide FF) antagonist BIBP3226 eliminated the anorexigenic effect caused by QRFP-26 administration. QRFP-26 affects neither general locomotion, behavioral patterns examined in the Open Field Test, nor anxiety. Conclusion: This study is the first to report the anorexigenic action of QRFP-26 following direct administration into the hypothalamus, emphasizing steady locomotion and anxiety levels. We have shown that the effect of QRFP can be linked to the neuropeptide Y (NPY) Y1 or NPFF receptors.
Tracking cloth deformation: A novel dataset for closing the sim-to-real gap for robotic cloth manipulation learning
Authors: Coltraro Franco , Borràs Júlia , Alberich-Carramiñana Maria , Torras Carme 
Published: February 2025

Robotic learning for deformable object manipulation—such as textiles—is often done in simulation due to the current limitation of perception methods to understand cloth’s deformation. For this reason, the robotics community is always on the search for more realistic simulators to reduce as much as possible the sim-to-real gap, which is still quite large especially when dynamic motions are applied. We present a cloth dataset consisting of 120 high-quality recordings of several textiles during dynamic motions. Using a Motion Capture System, we record the location of key-points on the cloth surface of four types of fabrics (cotton, denim, wool and polyester) of two sizes and at different speeds. The scenarios considered are all dynamic and involve rapid shaking and twisting of the textiles, collisions with frictional objects, strong hits with a long and thin rigid object and even self-collisions. We explain in detail the scenarios considered, the collected data and how to read it and use it. In addition, we propose a metric to use the dataset as a benchmark to quantify the sim-to-real gap of any cloth simulator. Finally, we show that the recorded trajectories can be directly executed by a robotic arm, enabling learning by demonstration and other imitation learning techniques. Dataset: https://doi.org/10.5281/zenodo.14644526 Video: https://fcoltraro.github.io/projects/dataset/
Role of the CHA2DS2-VASc score in predicting hospital stay and 90-day readmission among patients with atrial fibrillation in Syria
Authors: Antoun Ibrahim , Alkhayer Alamer , Alkhayer Alkassem , Mahfoud Yaman , Kotb Ahmed , Somani Riyaz , André Ng G , Zakkar Mustafa 
Published: February 2025

Objectives We assessed the CHA2DS2-VASc score for predicting hospital readmission risk and length of stay (LOS) in patients admitted with primary atrial fibrillation (AF). Methods This retrospective cohort study included patients with index admission for AF to Latakia’s tertiary center (May 2021–November 2023). Patients were followed 90 days to assess readmission. CHA2DS2-VASc was correlated with 90-day readmission, inpatient all-cause mortality, and LOS during index admission. Results In total, 717 patients were included; 320 (45%) were readmitted to the hospital within 90 days (58% men, 65% aged <65 years). Inpatient mortality was 4%; the median LOS was 2 days. There was an increase in the incident rate ratio (IRR) of LOS starting from a CHA2DS2-VASc of 2 (IRR: 2, 95% confidence interval [CI]: 1.7–2.2) to a score of >6 (IRR: 5, 95% CI: 1.8–10.7), compared with a score of 0. There was an incremental increase in the hazard ratio (HR) of readmission from a score of 1 (HR: 2.3, 95% CI: 1.3–4.1) to a score of >6 (HR: 41, 95% CI: 31–72) compared with a CHA2DS2-VASc of 0. Conclusion CHA2DS2-VASc could predict 90-day hospital readmission and LOS during the index admission in patients admitted with primary AF.
Vaginal bleeding during pregnancy: a retrospective cohort study assessing maternal and perinatal outcomes
Authors: Matar Maroun , Yared Georges , Massaad Christopher , Ghazal Kariman 
Published: February 2025

Objective Vaginal bleeding is a relatively common problem during pregnancy, with up to 25% of women experiencing some level of bleeding or spotting during pregnancy. Although not always a concern, pregnancy-related vaginal bleeding may detrimentally impact maternal and fetal health, and can arise at any stage during the pregnancy, usually linked with preterm labor, miscarriage, placental abnormalities, or implantation bleeding. As vaginal bleeding may compromise newborn health outcomes, for example, leading to low birth weight and neonatal intensive care unit (NICU) hospitalizations, it is imperative to understand the etiology of the bleed and effectively manage the patient’s condition. Thus, the aim of this study was to evaluate the prognostic value of vaginal bleeding as an indicator for at-risk pregnancies, aiming to elucidate its association with perinatal outcomes and pregnancy complications. Methods Consecutive pregnant female patients, aged 16–47 years, were included in this retrospective cohort study, and categorized into those with or without pregnancy-associated bleeding. Between-group differences and correlations in pregnancy complications and perinatal outcomes were statistically analyzed. Results Among a total of 441 patients, the incidence of vaginal bleeding was 74.4%, predominantly occurring in the first trimester (67.1%). No significant association was found between bleeding and maternal age, parity, abortion history, or total number of pregnancies. Educational level varied, with 64.9% of moderate education level experiencing bleeding. Pre-pregnancy comorbidities, such as diabetes, hypertension, and hypothyroidism, were not significantly correlated with bleeding. However, a history of infertility and progesterone treatment during pregnancy was significantly associated with bleeding episodes. An increased risk for NICU admissions and conditions such as respiratory distress in neonates was found, alongside a significant association with post-delivery bleeding and premature labor in the later trimesters. Conclusions Vaginal bleeding during pregnancy was not found to be significantly associated with maternal age, parity, abortion history, or total pregnancies. Nonetheless, the findings suggest a significant relationship between bleeding episodes and a history of infertility or progesterone treatment during pregnancy. Additionally, pre-pregnancy comorbidities, including diabetes, hypertension, and hypothyroidism were not associated with pregnancy bleeding. However, the latter was associated with increased risk of post-delivery bleeding, premature labor, and neonatal complications, such as respiratory distress and NICU admissions.
Fixed vs Weight-Based Dosing of Four-Factor Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Patients With a Non-Neurologic Hemorrhage
Authors: Stokes Tyson , Johnson Christopher , Fish Tyler , Mishler Aimee 
Published: February 2025

Background: There is a growing body of evidence to support that utilizing fixed dose vs weight-based dosing of Four-Factor prothrombin complex concentrate (4F-PCC) for Factor Xa inhibitor (FXaI) reversal is safe and efficacious. Objectives: The primary objective of this study was the rate of hemostatic efficacy of weight-based (50 units/kg) vs fixed dose (2000 units) 4F-PCC for FXaI reversal in patients presenting with a non-neurologic hemorrhage. Methods: This was a multi-center, retrospective chart review from January 21, 2020, to January 21, 2022. Patients were included if they were greater than or equal to 18 years of age and received one dose of 4F-PCC for FXaI reversal for a non-neurologic bleed. Hemostatic efficacy for this study was defined as the absence of hemorrhagic progression confirmed with imaging, >2 g/dl decrease in Hgb within 6 hours of 4F-PCC administration, reports of further significant bleeding in chart note documentation within 48 hours and a maintained or increased anti-factor Xa level from baseline. Results: Fifty-nine patients were included in this study (29 in the weight-based group and 30 in the fixed dose group). Rate of hemostatic efficacy was similar between fixed and weight-based dosing (93.3% vs 93.1% P = 1). Conclusions: This study adds to current evidence suggesting that a fixed dose 4F-PCC is both safe and efficacious for FXaI reversal in non-neurologic bleeds.
Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort
Authors: Díaz-Ramírez Fernando Piero , Saldaña-Alvarado Fiorella Vanessa , Gamboa-Cárdenas Rocío V. , Pimentel-Quiroz Victor , Reategui-Sokolova Cristina , Elera-Fitzcarrald Claudia , Noriega Erika , Rodriguez-Bellido Zoila , Pastor-Asurza Cesar , Perich-Campos Risto , Alarcón Graciela S. , Ugarte-Gil Manuel F. 
Published: February 2025

Objectives To determine the association between the occurrence of hypertension and damage accrual in patients with systemic lupus erythematosus (SLE). Materials and methods From January 2012 to January 2020, we evaluated 314 SLE patients, all members of the Almenara Lupus Cohort. We applied the American College of Cardiology/American Heart Association (ACC/AHA) guidelines to define hypertension, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) to determine organ damage, and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) to assess disease activity. We performed univariable and multivariable analysis using generalized estimating equations, adjusting for potential confounders (demographic factors, disease-related factors and treatment). Results 314 patients and 1695 visits were included; 93% of the patients were women. Their mean disease duration was of 6.8 years (SD: 6.4), and their age at diagnosis of 35.7 (SD: 13.4) years. Baseline damage was 0.8 (SD: 1.2) at the first visit, increasing by 0.15 points at the subsequent follow-up visit (SD: 0.46). The prevalence of hypertension in these patients was 56.4% at least once during their follow-up. In the multivariable analysis, hypertension remained associated with damage accrual (IRR: 1.645, 95% CI: 1.187–2.280, p = 0.003) after adjusting for confounders. In the analyses performed per domain, hypertension was associated with renal damage in the multivariable model (OR: 4.331, 95% CI 1.547–12.126, p = 0.005). Conclusion Hypertension was associated with subsequent greater damage in our SLE patients. Thus, providers involved on the care of these patients should monitor their blood pressure at all clinic visits.
A Prospective Observational Study of the Short-term Benefits of Pulmonary Rehabilitation in Connective Tissue Disease-related Interstitial Lung Diseases
Authors: Gedert Rosemary , Huang Suiyuan , Sabbagh Maya , McInroy Melissa , Huang Steven , Khanna Dinesh , Nagaraja Vivek 
Published: February 2025

Background and Objectives: Interstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD). (a) Pulmonary rehabilitation (PR) can be utilised to improve dyspnoea and quality of life in patients with chronic lung conditions, including both obstructive and restrictive lung diseases. (b) This study aims to determine if PR can be a useful therapy to improve functional capacity and self-reported measures of dyspnoea in patients with CTD-ILD. Methods: Patients with a diagnosis of CTD-ILD at a tertiary centre were prospectively enrolled to receive PR in this study. The primary outcome was a change in the 6-minute walk test (6MWT) between baseline and 8 weeks after PR. The secondary outcome measures included pulmonary function tests (PFTs) and Patient-Reported Outcomes Measurement Information System (PROMIS→) Dyspnoea, St George’s Respiratory Questionnaire (SGRQ), and Leicester Cough Questionnaire (LCQ), which were collected before and at 8 weeks after PR. P < .05 was considered statistically significant. Results: Twenty-one patients were included in the data analysis. The baseline characteristics are shown in Table 1 . Following PR, there was a statistically significant improvement in the 6MWT ( Figure 1 ). Improvement in scores was observed in LCQ and the symptom domain of the SGRQ. Trends towards improvement were noted in PROMIS→ Dyspnoea scores. Conclusion: In CTD-ILD patients, an 8-week course of PR led to improvements in functional capacity (6MWT) and certain quality of life domains (LCQ and symptom domain of SGRQ). Future studies are required to determine the longer-term benefit of PR in CTD-ILD patients and if these improvements are sustained.
Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study
Authors: De Troy Jasmine , Fendt Sarah-Maria , Hatse Sigrid , Neven Patrick , Smeets Ann , Laenen Annouschka , Wildiers Hans 
Published: February 2025

Background: Breast cancer is the most common malignancy in women and the leading cause of cancer-related death. Although most early-stage patients are cured, 20% to 30% develop metastases, significantly reducing survival rates. Recent research highlights the role of iron in cancer progression, although its full impact on breast cancer metastasis is not yet fully understood. Objectives: The aim of this study is to investigate the association between plasma iron levels at diagnosis of early-stage breast cancer and the risk of developing metastatic disease. Design: Retrospective single-center study. Methods: Patients with stage I to III breast cancer, diagnosed between 2007 and 2017, and with serum iron, transferrin saturation, and ferritin values available within 1.5 months before or after diagnosis were included. Cox proportional hazard models were applied to determine the association between iron levels and risk of metastasis. Results: In total, 1113 patients were included, 10% of them developed distant metastasis over a median follow-up period of 7 years. In multivariable analysis adjusting for age, stage, and subtype, transferrin saturation and serum iron were significantly associated with an increased risk of breast cancer metastasis. For each 10% increment of transferrin saturation at baseline, there was a 19% increase in metastatic risk (hazard ratio [HR] = 1.19; 95% confidence interval [CI] = [1.02-1.38]). Similarly, a serum iron increment of 10 µg/dL led to a 6% increase in risk (HR = 1.06; 95% CI = [1.01-1.12]). Ferritin was found not to be associated with metastatic risk (HR = 0.99; 95% CI = [0.98, 1.01]). There was no significant association with metastatic site or breast cancer subtype when adjusting for age and stage. Conclusion: Elevated transferrin saturation and serum iron at early breast cancer diagnosis are associated with increased risk for metastatic disease but not with location of metastases or breast cancer subtype. Further research is needed to understand the underlying mechanisms and to explore the potential of iron-targeted therapies.