bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation
Authors: Choi Michael , Sun Can‐Lan , Kurian Seira , Carter Andrea , Francisco Liton , Forman Stephen J , Bhatia Smita 
Published: August 2008

AbstractBACKGROUND.The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year.METHODS.CKD was defined as a sustained elevation of serum creatinine that indicated a glomerular filtration rate of <60 mL per minute per 1.73 m2for ≥3 months. The median age at HCT was 35 years (range, 18.1‐68.6 years), and the median length of follow‐up was 7.1 years after HCT (range, 1‐24.3 years).RESULTS.Sixty patients with CKD were identified, resulting in a cumulative incidence of 4.4% at 5 years (autologous HCT, 3.8%; matched‐sibling HCT, 4.5%; unrelated donor HCT, 10%;P= .09 compared with autologous HCT). Older age at HCT (relative risk [RR] per 5‐year increment, 1.33; 95% confidence interval [CI], 1.2‐1.5), exposure to cyclosporine without tacrolimus (RR, 1.90; 95% CI, 1.1‐3.4) or with tacrolimus (RR, 4.59; 95% CI, 1.8‐11.5), and a primary diagnosis of multiple myeloma (RR, 2.51; 95% CI, 1.1‐5.6) were associated with an increased risk of delayed CKD.CONCLUSIONS.In this study, the authors identified a subpopulation of patients who underwent HCT and remained at increased risk for CKD. The current findings set the stage for appropriate long‐term follow‐up of vulnerable patients. Cancer 2008. © 2008 American Cancer Society.
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors
Authors: Freeman Serena S. , Allen Steven W. , Ganti Ramapriya , Wu Jianrong , Ma Jing , Su Xiaoping , Neale Geoff , Dome Jeffrey S. , Daw Najat C. , Khoury Joseph D. 
Published: August 2008

AbstractBACKGROUND.Osteosarcoma cell lines and tumors have been shown to express epidermal growth factor receptor (EGFR) and harbor amplifications at the EGFR locus. In this study, the authors further analyzed the genomic features of EGFR in osteosarcoma tumors and investigated whether they correlate with phosphatase and tensin homolog (PTEN) expression and copy number status.METHODS.EGFR and PTEN expression was assessed by immunohistochemistry (n = 28), and copy number alterations at the EGFR and PTEN loci were surveyed using Affymetrix (Santa Clara, Calif) 50K single nucleotide polymorphism (SNP) arrays (n = 31) and fluorescence in situ hybridization (FISH) (n = 27). The EGFR tyrosine kinase domain was sequenced to survey for activating mutations (n = 34). In addition, EGFRvIII expression was assessed using reverse transcriptase polymerase chain reaction (n = 24). Results were correlated with available clinical information on 59 patients, with a median age of 14.1 years (range, 5‐23years) and median follow‐up of 4.4 years.RESULTS.EGFR expression was detected in the majority of osteosarcoma tumors surveyed (23 of 28; 82%). SNP arrays revealed evidence of frequent copy number gains at 7p11.2 and losses at 10q23.21. A sizeable subset (16 of 27 cases; 59%) showed gains at the EGFR locus using FISH (amplification in 4 of 27 [15%] and balanced chromosome 7 polysomy in 12 of 27 [44%]), and 12 cases showed deletions at the PTEN locus (biallelic deletions in 4 of 27 [15%] and monoallelic deletion in 9 of 27 [33%]). No activating mutations in the EGFR tyrosine kinase domain, EGFRvIII expression, or association with clinical findings were detected.CONCLUSIONS.EGFR expression and genomic gains at the EGFR locus are prevalent in osteosarcoma tumors, which also commonly harbor deletions at the PTEN locus. Cancer 2008. © 2008 American Cancer Society.
Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma
Authors: Kim Jin Hyoung , Yoon Hyun‐Ki , Sung Kyu‐Bo , Ko Gi‐Young , Gwon Dong Il , Shin Ji Hoon , Song Ho‐Young 
Published: August 2008

AbstractBACKGROUND.The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim of the study was to evaluate the clinical efficacy of TACE or TACI in patients with unresectable ICC and to identify prognostic factors associated with clinical success.METHODS.From 1997 to 2007, 49 patients with unresectable ICC were treated with TACE (n = 124) or transcatheter arterial chemoinfusion (TACI) (n = 96). Tumor response was evaluated based on computed tomography scans obtained 1 month to 3 months after TACE or TACI. Factors associated with clinical success were evaluated using multivariate logistic regression analysis. Factors associated with the survival period were evaluated using multivariate Cox regression analysis.RESULTS.After treatment, 27 (55%) of the patients showed radiographic response. Multivariate analysis confirmed that tumor vascularity (odds ratio [OR], 31.2; P = .002) was the only independent factor associated with radiographic response. The median and mean survival periods in our study patients were 12 and 24 months. Multivariate Cox regression analyses showed that tumor size (OR, 2.64; P = .048), tumor vascularity (OR, 13.5; P < .001), and the Child‐Pugh class (OR, 3.65; P = .014) were the independent factors associated with the length of the survival period.CONCLUSIONS.Hepatic intra‐arterial chemotherapy is well tolerated and may be effective to prolong survival of patients with unresectable ICC. Tumor vascularity is significantly associated with radiographic response. Large tumor size, tumor hypovascularity, and Child‐Pugh class B were poor prognostic factors for determining the patient survival period. Cancer 2008. © 2008 American Cancer Society.
Molecular Logic Operations Based on Surfactant Nanoaggregates
Authors: Qian Junhong , Xu Yufang , Qian Xuhong , Zhang Shenyi 
Published: August 2008

AbstractTwo molecular logic gates, FS1 and FS2, which display a UV and fluorescence behavior that is dependent on the pH value and the sodium dodecyl sulfate (SDS) surfactant concentration, are demonstrated based on the intramolecular charge‐transfer mechanism. They are constructed according to the inorganic salts that induce transformation from premicelle to micelle. The absorption band of FS1 at 480 nm is significantly enhanced only when both SDS and Na2SO4 are the input at high concentrations, in accordance with an AND logic gate. The OR logic function can be realized in a 3.5 mM SDS/FS2 aqueous solution with SDS and Na2SO4 as inputs along with the emission intensity as output. Furthermore, half addition and half subtraction can be incorporated in FS1. This is facilitated by the surfactant, due to its versatility.
Rare Earth and Alkaline Earth Metal Complexes with Me2Si‐Bridged Cyclopentadienyl‐Imidazolin‐2‐Imine Ligands and Their Use as Constrained‐Geometry Hydroamination Catalysts
Authors: Panda Tarun K. , Hrib Cristian G. , Jones Peter G. , Jenter Jelena , Roesky Peter W. , Tamm Matthias 
Published: August 2008

AbstractThe imidazolin‐2‐imino‐functionalized tetramethylcyclopentadiene, 3‐H, has been prepared by the reaction of two equivalents of 1,3‐diisopropyl‐4,5‐dimethylimidazolin‐2‐imine (1) with 5‐(chlorodimethylsilyl)‐1,2,3,4‐tetramethyl‐1,3‐cyclopentadiene (2). The reactions of 3‐H with the trimethylsilylmethyl (neosilyl) [Ln(CH2SiMe3)3(THF)2] (Ln = Sc, Y, Lu) complexes afford tetramethylsilane and the constrained‐geometry [(η5:η1‐3)Ln(CH2SiMe3)2] (Ln = Sc, 4a; Ln = Y, 4b; Ln = Lu, 4c) complexes, whereas the analogousbis(trimethylsilyl)amido (HMDS) calcium complex, [(η5:η1‐3)Ca(HMDS)(THF)] (5), can be obtained from 3‐H and [Ca(HMDS)2(THF)2] with loss of hexamethyldisilazane, (Me3Si)2NH. The molecular structures of 4a–4c and 5 have been established by X‐ray diffraction analyses, which confirm in all cases the formation of complexes with a chelating Me2Si‐bridged cyclopentadienyl‐imidazolin‐2‐imine ligand. The presence of short Ln–N and Ca–N bonds is indicative of the strong electron‐donating capacity of the imidazolin‐2‐imino nitrogen atom, which is based on the ability of the imidazolium ring to effectively stabilize a positive charge. The rare earth metal complexes 4a–4c can be used as efficient catalysts for the hydroamination/cyclization reaction of terminal aminoalkenes and aminoalkynes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
New Stack Design of Micro‐tubular SOFCs for Portable Power Sources
Authors: Suzuki T. , Funahashi Y. , Yamaguchi T. , Fujishiro Y. , Awano M. 
Published: August 2008

AbstractMicro‐tubular solid oxide fuel cells (SOFCs) have high thermal stability and higher volumetric power density, which are considered to be ideal features for portable power sources and auxiliary power units for automobile. Here, we report a new stack design using anode supported micro‐tubular SOFCs with 2 mm diameter using Gd doped CeO2 (GDC) electrolyte, NiO‐GDC anode and (La, Sr)(Co, Fe)O3 (LSCF)‐GDC cathode. The new stack consists of three bundles with five tubular cells, sealing layers and interconnects and fuel manifolds. The performance of the stack whose volume is 1 cm3 was shown to be 2.8 V OCV and maximum power output of 1.5 W at 500 °C, applying air only by natural convection. The results also showed strong dependence of the fuel flow rates on the stack performance, which was correlated to the gas diffusion limitation.
Head and neck mucosal melanoma: Experience with 42 patients, with emphasis on the role of postoperative radiotherapy
Authors: Meleti Marco , Leemans C. René , de Bree Remco , Vescovi Paolo , Sesenna Enrico , van der Waal Isaäc 
Published: August 2008

AbstractBackground.Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established.Methods.The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported.Results.Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies.Conclusions.The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Clinical predictors of larynx preservation after multiagent concurrent chemoradiotherapy
Authors: Rodriguez Cristina P. , Adelstein David J. , Rybicki Lisa A. , Saxton Jerrold P. , Lorenz Robert R. , Wood Benjamin G. , Strome Marshall , Esclamado Ramon M. , Lavertu Pierre , Carroll Marjorie A. 
Published: August 2008

AbstractBackground.Determining which patients benefit from larynx preservation strategies remains problematic. We reviewed our experience using multiagent concurrent chemoradiotherapy to identify clinical predictors for success.Methods.Cisplatin and fluorouracil were given during weeks 1 and 4 of radiation to 115 patients with locoregionally advanced larynx or hypopharynx squamous cell cancer without cartilage invasion or laryngeal destruction. Laryngectomy was reserved for local failure.Results.The 5‐year Kaplan–Meier projected overall survival was 58%, survival with larynx preservation 52%, local control without surgery 82%, local control (including surgical salvage) 94%, and survival with functional larynx 49%. Local control without surgery was superior in patients with T1‐2 versus T3‐4 tumors (97% vs 77%, p = .032). No other clinical parameters proved predictive of local control.Conclusion.Larynx preservation was successful in all subsets of appropriately selected patients. Although local failure was more likely in patients with T3‐4 tumors, it was infrequent and surgical salvage was effective. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
E‐cadherin loss and ΔNp73L expression in oral squamous cell carcinomas showing aggressive behavior
Authors: Foschini Maria P. , Cocchi Roberto , Morandi Luca , Marucci Gianluca , Pennesi Maria G. , Righi Alberto , Tosi Anna L. , de Biase Dario , Pession Annalisa , Montebugnoli Lucio 
Published: August 2008

AbstractBackground.This article sought to investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCCs).Methods.Fifty‐eight cases were studied for E‐cadherin and the truncated dominant‐negative isoform of p63 (ΔNp63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by reverse transcriptase‐polymerase chain reaction (RT‐PCR) to disclose the presence of the truncated variant ΔNp73L.Results.E‐cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty‐four of 38 (63%) cases showing low E‐cadherin expression had lymph node metastases at presentation compared with 5 of 20 (25%) (p <.01) cases showing high E‐cadherin expression. The high predictive value was also maintained when a low expression of E‐cadherin was associated with immunohistochemical high expression of ΔNp63. The association between low E‐cadherin expression and ΔNp73L (as seen with reverse transcriptase‐polymerase chain reaction) was highly predictive for developing lymph node metastases, especially in small tumors (T1\T2). When this association occurred, metastases developed in 62.5% of cases during the follow‐up compared with 16.1% in those which did not show low E‐cadherin expression and presence of ΔNp73L.Conclusion.This study shows that low E‐cadherin expression is useful for predicting lymph node metastases in cases of OSCC. The predictive value is enhanced when low E‐cadherin positivity is associated with ΔNp63 and ΔNp73L expression. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Fc receptor‐like 1–5 molecules are similarly expressed in progressive and indolent clinical subtypes of B‐cell chronic lymphocytic leukemia
Authors: Kazemi Tohid , Asgarian‐Omran Hossein , Hojjat‐Farsangi Mohammad , Shabani Mahdi , Memarian Ali , Sharifian Ramazan Ali , Razavi Seyed Mohsen , Jeddi‐Tehrani Mahmood , Rabbani Hodjatallah , Shokri Fazel 
Published: August 2008

AbstractFc receptor‐like (FCRL) 1–5 molecules are exclusively expressed in B‐cells and have recently been considered as potential targets for immunotherapy of B‐cell malignancies. In this study, the expression pattern of FCRL1–5 molecules was investigated in Iranian patients with B‐cell chronic lymphocytic leukemia (B‐CLL). Our RT‐PCR results have demonstrated that all FCRL molecules, except FCRL4, were expressed in the vast majority of the patients with B‐CLL. However, comparison of the relative mRNA expression levels of FCRL between B‐CLL (n = 86) and elderly normal subjects (n = 10) revealed significantly lower expression levels of FCRL1 (p < 0.0001), FCRL3 (p = 0.01) and FCRL4 (p = 0.002), but not FCRL2 or FCRL5, in cases with B‐CLL. No significant differences were observed between the indolent and progressive subtypes of patients with B‐CLL. Comparison between the mutated and unmutated subtypes revealed a significantly higher expression level of FCRL3 (p = 0.017) in patients with mutated CLL. Surface and intracytoplasmic expression of FCRL1, 2, 4 and 5 in leukemic cells of 12 patients by flow cytometry revealed similar results to those obtained by RT‐PCR with a few exceptions. Thus, while FCRL4 was expressed in only 2 samples at intracytoplasmic level, FCRL1 and 2 were expressed in the majority of samples, both at surface and intracytoplasm. FCRL5 protein was also detected in 10 samples, but surface expression was confirmed in only 2. Analysis of B‐cells from 5 normal subjects by flow cytometry revealed higher expression levels of FCRL molecules compared to CLL. Our results indicate differential expression of FCRL molecules in B‐CLL and suggest the potential implication of FCRL1 and 2 for immunotherapeutic interventions. © 2008 Wiley‐Liss, Inc.
Clean synthesis of methyl N‐phenyl carbamate over ZnO‐TiO2 catalyst
Authors: Li Fang , Wang Yanji , Xue Wei , Zhao Xinqiang 
Published: August 2008

AbstractBACKGROUND: Methyl N‐phenyl carbamate (MPC) is an intermediate for the preparation of methylene diphenyl diisocyanate (MDI), which is an important monomer for polyurethane synthesis. The synthesis of MPC by the reaction of aniline and dimethyl carbonate (DMC) is becoming more and more attractive. However, most of the catalysts used in MPC synthesis are homogeneous and not environment‐friendly. Therefore, it is important and necessary to develop a new kind of oxide catalyst, that is not only friendly to the environment, but also exhibits higher activity and longer service time.RESULTS: A new heterogeneous catalyst, ZnO‐TiO2, was prepared for MPC synthesis. ZnO‐TiO2 catalyst with a molar ratio Ti/Zn = 2 and calcined at 673 K exhibited good catalytic activity: aniline conversion was 96.9% and MPC yield 66.7%.CONCLUSION: ZnO‐TiO2 exhibits better catalytic activity than ZnO or TiO2 alone, which may result from the formation of ZnTiO3 and Zn2TiO4. Compared with ZnTiO3, Zn2TiO4 has better selectivity for MPC synthesis. Lewis acid sites with weaker acid strength favour MPC synthesis. The catalyst activity can be recovered almost completely by calcination. Copyright © 2008 Society of Chemical Industry
Supercritical antisolvent micronisation of synthetic all‐trans‐β‐carotene with tetrahydrofuran as solvent and carbon dioxide as antisolvent
Authors: Tavares Cardoso Miguel A , Antunes Sofia , van Keulen Frederik , Ferreira Bruno S , Geraldes Augusto , Cabral Joaquim MS , Palavra António MF 
Published: August 2008

AbstractBACKGROUND: Supercritical antisolvent (SAS) micronisation of synthetic trans‐β‐carotene was studied using tetrahydrofuran (THF) as solvent and supercritical carbon dioxide (CO2) as antisolvent, with the objective of increasing its bioavailability and facilitating its dispersion in oil and emulsion formulations as a result of its smaller particle size. The micronised powder was analysed by scanning electron microscopy and high‐performance liquid chromatography. Micronisation experiments were performed in order to evaluate the effects of temperature (308.15–333.15 K), pressure (6.5–13 MPa) and concentration of the liquid solution (6–9 g L−1). The effect of the supercritical CO2/THF flow ratio in the range between 4 and 44 (on a mass basis) was also analysed. Determinations of equilibrium concentrations of β‐carotene in the CO2/THF mixture were also performed.RESULTS: The particle size obtained ranged from 1 to 500 µm, with mean particle diameters around 100 µm. Three types of morphology were found in the precipitated powder: crystalline with superficial pores and leaf‐like appearance; crystalline with regular shapes and blade‐like edges; and crystalline without superficial pores and leaf‐like apearance. The Peng–Robinson equation of state was used to calculate the density of the CO2/THF binary mixture, and the solubility of β‐carotene in this mixture was correlated with its density.CONCLUSION: The use of the SAS technique to micronise β‐carotene proved to be efficient, and the absence of degradation in the micronised powder allows the industrial application of this technique. Copyright © 2008 Society of Chemical Industry
Improvement of performance in label‐free quantitative proteome analysis with monolithic electrospray ionization emitter
Authors: Wang Fangjun , Ye Mingliang , Dong Jing , Tian Ruijun , Hu Lianghai , Han Guanghui , Jiang Xinning , Wu Ren'an , Zou Hanfa 
Published: August 2008

AbstractThe postcolumn void volume, which is introduced by the connecting tubing and void ESI emitter in the nanoflow LC coupled with MS/MS system (μLC‐MS/MS), is harmful for the analysis of peptides in shotgun proteome analysis. A new type of porous C12 monolithic ESI emitter was prepared to eliminate the disruption and mixing effects occurring in the connecting tubing and void emitter. It was demonstrated that the porous hydrophobic monolith inside the emitter played a key role in retaining the good peak profile, and the average peak capacity of the whole separation system increased 12.8% in contrast to commercially available void emitter. Then, the porous C12 monolithic emitter was applied in label‐free quantitative proteome analysis of two standard protein mixtures that were spiked into the tryptic digest of mouse livers extract. Compared to commercially available void ESI emitter, the number of proteins with reliable results in quantification increased greatly. And the relative quantities of the four standard proteins were all determined with the relative error ⪇6.8%. However, quantitative information of only three standard proteins could be obtained when void emitter was used.
Soil quality indices for evaluation of long‐term land use and soil management practices in semi‐arid sub‐tropical India
Authors: Masto R. E. , Chhonkar P. K. , Purakayastha T. J. , Patra A. K. , Singh D. 
Published: August 2008

AbstractLand use changes and soil management can potentially alter soil quality. A study was conducted to assess the long‐term (>20 years) effects of perennial trees (PT), vegetable crops (VC), rice–wheat (RW) system, sewage‐irrigated fields (SF), maize–wheat (MW) system and uncultivated soils (US) on soil quality. Soil physical quality parameters were significantly affected only in the SF system when compared with the US soil, particularly for bulk density (BD 1·51 Mg m−3 in SF vs. 1·34 in US). Among chemical parameters, electrical conductivity was high in SF, and soil nutrients (N, P, K, S, Zn, Fe, Cu and Mn) were well above the critical limits of deficiency in all the systems. Soil parameters were integrated into soil quality indices (SQIs) by unscreened transformation and principal component analysis (PCA). SQI observed under each system were compared with the US to assess the degree of degradation. Mean SQI differences showed that PT (+16·02 per cent), VC (+4·80 per cent), RW (+10·04 per cent), and MW (+11·30 per cent) are aggrading, whereas SF (−2·06 per cent) is degrading with respect to the reference soil (US). Adoption of MW system proved to be better than traditional RW; and in general agricultural crops have a significant advantage than VC, in terms of maintaining soil quality. Sewage irrigation is not a sustainable practice and long‐term use may degrade the soil. Among the SQIs, PCA with nonlinear scoring function (NLSF) based SQI was effective in judging land degradation due to soil quality changes as affected by long‐term land use and soil management practices. Copyright © 2008 John Wiley & Sons, Ltd.
Slow and fast light: Controlling the speed of light using semiconductor waveguides
Authors: Mørk J. , Öhman F. , van der Poel M. , Chen Y. , Lunnemann P. , Yvind K. 
Published: August 2008

AbstractWe give an overview of slow‐ and fast‐light effects in semiconductor active waveguides. Experimental and theoretical results are presented, emphasizing the physics of these phenomena and the limitations imposed by the carrier dynamical processes.