bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived attitudes toward LGBTQ + physicians among individuals with psychiatric illness in the religiously diverse Southern Region of Thailand: a multihospital-based survey
Authors: Pitanupong Jarurin , Wichitnark Garn , Wiwattanaworaset Pakawat , Tepsuan Laddaporn , Norphun Naruttha , Yakkaphan Puangsan 
Published: March 2024

Abstract
Objectives
This study purposed to analyze perceived attitudes toward LGBTQ + physicians and related factors among individuals with psychiatric illnesses in southern Thailand.

Materials and methods
From May to July 2023, a cross-sectional study was conducted at four psychiatric outpatient clinics in Southern Thailand. The questionnaires utilized were: 1) a demographic information questionnaire, 2) a questionnaire regarding attitudes toward LGBTQ + physicians, 3) a questionnaire evaluating individuals’ attitudes toward LGBTQ + physicians while receiving medical attention, and 4) a patient-doctor relationship questionnaire. All data were analyzed using descriptive statistics, and the factors associated with perceived attitudes toward LGBTQ + physicians were analyzed using the Wilcoxon rank sum test, the Kruskal–Wallis test, and linear regressions. The analyses were conducted using the R Foundation for Statistical Computing software, version 4.3.1. Statistical significance was defined as a p-value of less than 0.05.

Results
Among our 542 participants, the mean age was 36.3 ± 14.1 years. The majority were female (64.6%), Buddhist (62.4%), and diagnosed with depression (46.3%). Approximately three-quarters showed a good doctor-patient relationship (74.0%). The median (IQR) score of the perceived attitudes toward LGBTQ + physicians was 75 (66, 88). Predominantly, the LGBTQ + physicians were perceived as normal (76.3%) and being a viable part of society (88.7%). Moreover, our participants disagreed with the view that being an LGBTQ + physician was a sin (70.6%) or immoral (68.2%). They felt comfortable during history taking (79.0%), physical examination not involving private parts of the body (72.5%), and management for both medical (78.4%) and psychiatric conditions (81.4%) at the hands of LGBTQ + physicians. However, they reported feeling uncomfortable during history taking involving private matters (6.3%) and the physical examination of private parts (16.4%). Older age, absence of LGBTQ + close relatives/friends, and being a Muslim were associated with lower scores of perceived attitudes toward LGBTQ + physicians. Conversely, a higher level of education and a reported mismatch between the patient’s sex and gender were associated with higher scores.

Conclusions
Most participants reported positive perceived attitudes toward LGBTQ + physicians. However, some age groups and adherents of Islam showed lower perceived attitude scores and reported feeling uncomfortable receiving medical treatment from LGBTQ + physicians. On the one hand, LGBTQ + physicians have cause to be concerned about this point; on the other hand, finding appropriate approaches to promote positive attitudes toward LGBTQ + physicians among these groups of people remains a necessity.
Determination of Euler pole parameters for Sundaland plate based on updated GNSS observations in Sumatra, Indonesia
Authors: Alif Satrio Muhammad , Ching Kuo-En , Sagiya Takeshi , Wahyuni Widya Nabila 
Published: March 2024

AbstractTo provide a precise Euler pole parameter of Sundaland plate for earthquake potential evaluation in Sumatra, Indonesia after the 2004 M9.2 Aceh earthquake, we adopted 37 new Global Navigation Satellite System (GNSS) observations in Sumatra and 30 transformed published velocities in Indochina and Malaysia under the International Terrestrial Reference Frame 2014 (ITRF2014). The 37 GNSS data were processed using the software Bernese v.5.2. The GNSS velocities were calculated by the coordinate time series analysis with the least squares method. The grid search algorithm was used in Euler pole parameter estimation, which was validated using the bootstrap resampling. The optimized Euler pole parameters are the latitude of 45.63 ± 0.45°, the longitude of − 88.71 ± 0.38° and the angular velocity of 0.337 ± 0.002°/Myr in counterclockwise direction. Besides, the distinguishable and systematic pattern in space is shown in the residual velocities, which may imply the possibility of minor postseismic deformation, Tibetan crustal flows, or the hypothesis that the Sundaland Plate is composed of several microplates.
Prior experiences as students and instructors play a critical role in instructors’ decision to adopt evidence-based instructional practices
Authors: Kraft Annika R. , Atieh Emily L. , Shi Lu , Stains Marilyne 
Published: March 2024

Abstract
Background
There has been a growing interest in characterizing factors influencing teaching decisions of science, technology, engineering, and mathematics (STEM) instructors in order to address the slow uptake of evidence-based instructional practices (EBIPs). This growing body of research has identified contextual factors (e.g., classroom layout, departmental norms) as primary influencers of STEM instructors’ decision to implement EBIPs in their courses. However, models of influences on instructional practices indicate that context is only one type of factor to consider. Other factors fall at the individual level such as instructors’ past teaching experience and their views on learning. Few studies have been able to explore in depth the role of these individual factors on the adoption of EBIPs since it is challenging to control for contextual features when studying current instructors. Moreover, most studies exploring adoption of EBIPs do not take into account the distinctive features of each EBIP and the influence these features may have on the decision to adopt the EBIP. Rather, studies typically explore barriers and drivers to the implementation of EBIPs in general. In this study, we address these gaps in the literature by conducting an in-depth exploration of individual factors and EBIPs’ features that influence nine future STEM instructors’ decisions to incorporate a selected set of EBIPs in their teaching.

Results
We had hypothesized that the future instructors would have different reasoning to support their decisions to adopt or not Peer Instruction and the 5E Model as the two EBIPs have distinctive features. However, our results demonstrate that instructors based their decisions on similar factors. In particular, we found that the main drivers of their decisions were (1) the compatibility of the EBIP with their past experiences as students and instructors as well as teaching values and (2) experiences provided in the pedagogical course they were enrolled in.

Conclusions
This study demonstrates that when considering the adoption of EBIPs, there is a need to look beyond solely contextual influences on instructor’s decisions to innovate in their courses and explore individual factors. Moreover, professional development programs should leverage their participants past experiences as students and instructors and provide an opportunity for instructors to experience new EBIPs as learners and instructors.
Squamous cell carcinoma of the anus successfully treated with multidisciplinary therapy for metachronous metastatic and local recurrences after DCF chemotherapy: a case report
Authors: Naito Ryozan , Shiraishi Takuya , Hosoi Nobuhiro , Watanabe Takayoshi , Shioi Ikuma , Shibasaki Yuta , Nakazawa Nobuhiro , Osone Katsuya , Okada Takuhisa , Sano Akihiko , Sakai Makoto , Ogawa Hiroomi , Sohda Makoto , Shirabe Ken , Saeki Hiroshi 
Published: March 2024

Abstract
Background
Docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy is reportedly an effective treatment strategy for squamous cell carcinoma of the anus (SCCA). However, studies regarding its use in Japanese patients remain scarce.

Case presentation
Here, we present the case of an 82-year-old woman with SCCA, cStage IIIB. Chemoradiotherapy was initiated after colostomy of the anorectal mass; however, para-aortic lymph node recurrence was observed 3 months after treatment completion. Five courses of DCF chemotherapy were subsequently administered, resulting in a complete response (CR). Two years and 1 month later, the aortic lymph node was enlarged again, and the patient achieved CR again after radiotherapy. Nine months later, local recurrence was detected in the anal canal, and laparoscopic perineal rectal amputation was performed. The patient remains progression-free 5 years and 10 months after the initial treatment and 1 year and 7 months after the final treatment.

Conclusions
Our findings suggest that complementary treatment after DCF chemotherapy may be efficacious in Japanese patients with SCCA and help achieve CR. Despite occasional local recurrences, this approach may help achieve long-term progression-free survival.
Sex-dependent vulnerability for Wistar rats model following intranasal instillation with Klebsiella pneumoniae ATCC 43816 causing lobar pneumonia
Authors: Diboue Betote Patrick Hervé , Del Florence Ndedi Moni Esther , Matchuenkam Sonia Raïssa Gayap , Beack Sandrine Suzanne Bayengue , Fifen Rodrigue , Ouedraogo Raogo , Agbor Gabriel A. , Semde Rasmané , Nnanga Nga , Nyegue Maximilienne Ascension 
Published: March 2024

Abstract
Background
Klebsiella pneumoniae has become one of the major threats to public health as it causes nosocomial and community-acquired infections like lobar pneumonia. This infection causes acute inflammation in the lung, characterized by the recruitment of polymorphonuclear cells, generating free radicals, and decreasing the endogenous antioxidant balance system. Many experimental studies have focused on the induction, progression and resolution of infection up to its peak, but these documented processes remain highly random and their sex dependence un-elicited. These fluctuations of physiopathological parameters would impact disease progression depending on the animal’s model and bacterial strain used. The present study investigated the sex-dependent vulnerability of Wistar rats to K. pneumoniae ATCC 43816 lobar pneumonia induced by the intranasal instillation method.

Methods
Experimental pneumonia was induced by K. pneumoniae ATCC 43816 in male and female Wistar rats following intranasal instillation. The physiopathogenesis of the disease was studied by bacteriological and histopathological exams, histomorphometric analysis of the blood and/or lung tissue, and body weight loss in infected animals. In addition, the overall severity of lesions was determined by the total score obtained by averaging the individual scores from the same group of animals.

Results
The K. pneumoniae ATCC 43816 strain showed inoculation dose-, incubation time of the disease- and sex-dependent- differences in its ability to induce lobar pneumonia. Evaluation of different parameters showed that the disease peaked on day 15 post-inoculation, with more pathogenic effects on female rats. This observed sex-dependence difference in Wistar rats was mainly highlighted by the determined lethal dose 50 (LD50), bacterial load count in whole blood and lung tissues, body weight loss, inflammatory granulomas forming and diffuse alveolar damages. The pathogenicity was confirmed by scoring the severity of pathologic lesions of lung tissues.

Conclusions
The results obtained highlighted the gender-dependency in the physiopathogenesis processes of K. pneumoniae ATCC 43816 induced-lobar pneumonia, in Wistar rats. Female Wistar rats’ susceptibility is useful in studying pathology and in preclinical trial investigations of new treatments for infectious pneumonia.
“English like Hindi”: Chetan Bhagat, Popular Fiction, and India’s Voice
Authors: Srinivasan Ragini Tharoor 
Published: March 2024

AbstractThis essay examines the rise of Chetan Bhagat, an icon of the New India “after English” who ironically writes his best-selling popular fictions in English. When Bhagat’s demotic English travels outside India, it is taken up by readers and critics whose responses to his work reveal the persistence of the fantasy of accessing India’s unmediated voice. The essay reads the extant Anglo-American critical discourse on Bhagat, with special attention to the postcritical and post-postcolonial turns in contemporary literary scholarship. It argues that Bhagat’s anointment as a global Anglophone literary icon with purchase on the “real” India lays bare a problem endemic to English literary studies—namely, the problem of enacting comparative literary analysis within English itself. It also raises a number of questions at the intersections of world literature and the global Anglophone, which are rival strategies for the teaching of non-Western literatures in English in US academe. In its concluding sections, the essay considers whether it is possible to teach Bhagat’s “English like Hindi” without allowing it to masquerade as a conduit to a supposedly authentic Indian vernacular sphere.
Constraint against Constraint: Hunger Strikes and the Score
Authors: DeMay Timothy 
Published: March 2024

AbstractIn 1961, the poet Jacques Roubaud was dismissed by the French military in Algeria after undergoing a series of “clandestine hunger strikes,” an act he later referred to as his “very first constraint.” By using a term that at once refers to a particular and increasingly prevalent resistance act, the rules and procedures used by post–World War II avant-garde artists and writers, and oppressive structures like prisons that delimit lives, “constraint” provides a way to rethink the history of avant-garde procedural poetry through the act of the hunger strike. This essay analyzes the constraint as a “score,” a method of making that allows for the repeatability and transformation of forms across contexts. This repetition with a difference is underscored by a cast of 1960s and 1970s writers from France, the United States, and Morocco, including Roubaud, Norman H. Pritchard, Bernadette Mayer, Saïda Menebhi, and Abdallah Zrika. Foregrounding the hunger strike and seeing an aesthetics that accords with this provocative and popular act, this essay makes a case for avant-garde practice, rather than the avant-garde object, as acts that might not only reorganize everyday life into weapons and tools, but also thread trans-national possibilities of solidarity through a shared political form.
Empathy in Post-Oslo Palestinian Literature: Reading between Identification and Recognition in Ala Hlehel’s Au Revoir Acre and Ibtisam Azem’s The Book of Disappearance
Authors: Green Rachel 
Published: March 2024

Abstract
This article considers Ala Hlehel’s Au Revoir Acre and Ibtisam Azem’s The Book of Disappearance, two Arabic-language novels published in 2014 by Palestinian authors with Israeli citizenship. It argues that both texts thematize empathy, despite its familiar pitfalls, as central to their imaginings of an inclusive political future in Israel/Palestine in the post-Oslo era. In revivifying eighteenth-century Acre and the city’s triumphant defeat of Napoleon in 1799, Hlehel’s creatively embellished historical novel curates an effortless cascade of emotionally contagious intergroup identification in a space of historic Palestinian triumph. Conversely, in positing the sudden and inexplicable disappearance of all Palestinians from Historic Palestine, set against the backdrop of a troubled friendship and a searching soul, Azem’s speculative work offers a Fanonian critique of the politics of recognition and a concomitant turn to affect. Together, the texts constitute a future-oriented strand of contemporary Palestinian writing that counterintuitively thematizes intergroup empathy, drawing upon its symbolic currency to scaffold a pedagogical hermeneutics of decolonial overture.
Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination
Authors: Konietzny Anja , Han Yuhao , Popp Yannes , van Bommel Bas , Sharma Aditi , Delagrange Philippe , Arbez Nicolas , Moutin Marie-Jo , Peris Leticia , Mikhaylova Marina 
Published: March 2024

ABSTRACT
In neurons, the microtubule (MT) cytoskeleton forms the basis for long-distance protein transport from the cell body into and out of dendrites and axons. To maintain neuronal polarity, the axon initial segment (AIS) serves as a physical barrier, separating the axon from the somatodendritic compartment and acting as a filter for axonal cargo. Selective trafficking is further instructed by axonal enrichment of MT post-translational modifications, which affect MT dynamics and the activity of motor proteins. Here, we compared two knockout mouse lines lacking the respective enzymes for MT tyrosination and detyrosination, and found that both knockouts led to a shortening of the AIS. Neurons from both lines also showed an increased immobile fraction of endolysosomes present in the axon, whereas mobile organelles displayed shortened run distances in the retrograde direction. Overall, our results highlight the importance of maintaining the balance of tyrosinated and detyrosinated MTs for proper AIS length and axonal transport processes.
Outcomes of AV fistula formation for dialysis patients using interrupted sutures one-year single center study
Authors: Naz Farah , Javaid Rana Hassan , Noor Sara , Katpar Hira 
Published: March 2024

Objectives: To document the Outcomes of AV fistula formation for dialysis patients using interrupted sutures.
Methods: In this Cross-sectional study conducted at PNS Shifa Karachi, from June 2022 to June 2023, patients above 18 years of age, male or female, with ESRD/CKD were included. After clinical screening and ultrasound doppler, the distal most part of wrist was considered as a site for radio cephalic AVF. Operation was performed under surgical loupe with 4.5x magnification. Standard incision of about 4-5 cm oblique proximal to the wrist crease was given at the volar surface on the radial side of Distal forearm, extending till the lateral side up to the snuffbox. Subcutaneous tissue was incised and dissection was done to identify the cephalic vein and radial artery. Distal most end of the cephalic vein was ligated using vicryl 4-0 suture and cephalic vein dissected free from the underling tissue to mobilize it up to the radial artery.
Results: During the study N=35 patients who required AVF creation visited the department. The mean age of the study participants was 59.34±15.48. If thrill at the site of AVF and backflow at cut end of cephalic vein were present the surgeons were satisfied, higher satisfaction among the surgeon was achieved in the AVF created at brachiocephalic artery while the diameter of vessels didn’t contribute in surgeon satisfaction.
Conclusion: Presence of thrill at the site of AVF and backflow at cut end of cephalic vein have strong association with good prognosis of AVF.
doi: https://doi.org/10.12669/pjms.40.5.8990
How to cite this: Naz F, Javaid RH, Noor S, Katpar H. Outcomes of AV fistula formation for dialysis patients using interrupted sutures one-year single center study. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.8990
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Weight reduction among females undergoing laparoscopic ventral hernia repair: The role of Calcium and Vitamin D3
Authors: AlMulhim Saleh Abdulrahman , AlNaim Mounther Mohammed , Khan Abdul Sattar , Memon Abdul Qadeer , AlArfaj Haytham Mohammed , Abdulqader Ahmad A. Al , AlMulhim Abdulrahman Saleh 
Published: March 2024

Objective: To evaluate the role of Vitamin-D and calcium supplementation on preoperative weight reduction in obese women before laparoscopic ventral hernia repair.
Methods: This double-blind clinical trial was conducted at the affiliated health centers of King Faisal University, Al-Ahsa, Saudi Arabia from January 2021 to December 2021. It included forty-five obese women aged 24-56 years, with body mass index (BMI) of 34.0–48.0 kg/m2. They were randomly allocated into two groups; the Group-A (N=22) included obese women who received supplementation of 5000 IU cholecalciferol (Vitamin-D3), and 1000 mg calcium daily for 12 months, while the Group-B (N=23) received no treatment. Measurement of change in weight and BMI and comparison of their pre-operative weight reduction, laparoscopic operative time, and length of hospital stay was done.
Results: There were no differences in patients’ biographic data between the two groups. During the study, Vitamin-D level in the patients increased and there was a significant positive association with weight loss. In group-A, the mean weight loss was 11.8±3.5 kg. At the end of first year, their BMI decreased from 36.1±1.6kg/m2 at baseline to 29.7±2.6 kg/m2, whereas in-group-B, the mean weight loss was 6.8±3.1 kg and their BMI decreased from 36.9±2.69kg/m2 at baseline to 32.7±0.93kg/m2. The operation time and the length of hospital stay were shorter in group-A (107 vs.128.min) and (3 vs. 5 days) respectively as compared to Group-B.
Conclusion: Vitamin-D and calcium supplementation contributes to a remarkable weight reduction of preoperative obese female patients, which in turn is associated with significantly better outcome of laparoscopic repair of ventral hernia.
doi: https://doi.org/10.12669/pjms.40.5.9047
How to cite this: AlMulhim SA, AlNaim MM, Khan AS, Memon AQ, AlArfaj HM, Al Abdulqader AA, et al. Weight reduction among females undergoing laparoscopic ventral hernia repair: The role of Calcium and Vitamin D3. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.9047
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.