bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro assessment of internal implant-abutment connections with different cone angles under static loading using synchrotron-based radiation
Authors: Angermair Johannes , Iglhaut Gerhard , Meyenberg Konrad , Wiest Wolfram , Rack Alexander , Zabler Simon , Fretwurst Tobias , Nelson Katja , Kernen Florian 
Published: March 2024

Abstract
Background
The stability of implant-abutment connection is crucial to minimize mechanical and biological complications. Therefore, an assessment of the microgap behavior and abutment displacement in different implant-abutment designs was performed.

Methods
Four implant systems were tested, three with a conical implant-abutment connection based on friction fit and a cone angle < 12 ° (Medentika, Medentis, NobelActive) and a system with an angulated connection (< 40°) (Semados). In different static loading conditions (30 N − 90º, 100 N − 90º, 200 N − 30º) the microgap and abutment displacement was evaluated using synchrotron-based microtomography and phase-contrast radioscopy with numerical forward simulation of the optical Fresnel propagation yielding an accuracy down to 0.1 μm.

Results
Microgaps were present in all implant systems prior to loading (0.15–9 μm). Values increased with mounting force and angle up to 40.5 μm at an off axis loading of 100 N in a 90° angle.

Conclusions
In contrast to the implant-abutment connection with a large cone angle (45°), the conical connections based on a friction fit (small cone angles with < 12°) demonstrated an abutment displacement which resulted in a deformation of the outer implant wall. The design of the implant-abutment connection seems to be crucial for the force distribution on the implant wall which might influence peri-implant bone stability.
Presence of tuberculosis symptoms among HIV-positive men who have sex with men (MSM) in Zimbabwe
Authors: Mapingure Munyaradzi , Chingombe Innocent , Dzinamarira Tafadzwa , Moyo Brian , Samba Chesterfield , Murigo Delight , Mugurungi Owen , Mbunge Elliot , Makota Rutendo Birri , Murewanhema Grant , Musuka Godfrey 
Published: March 2024

AbstractWe conducted secondary data analysis using a biobehavioral survey dataset of 1538 MSM from Zimbabwe. Survey participants were screened for the four symptoms suggestive of tuberculosis infection using the WHO TB screening algorithm. Results: All participants experienced at least one symptom suggestive of tuberculosis. 40% of HIV-positive MSM reported having had a cough in the last month and 13% of them experienced unexpected weight loss. The prevalence of experiencing any of the four TB symptoms amongst HIV-positive MSM was 23%.ContributionThere is an urgent need for active TB case finding and treatment amongst HIV-positive MSM in Zimbabwe. Clinicians will need to ensure that MSM who need TB testing receive it timeously.
Have we bothered to ask? Exploration of the attitude of teachers toward participating in inclusive education research
Authors: Opoku Maxwell Peprah , Nketsia William , Wisdom Mprah Kwadwo , Amponteng Michael 
Published: March 2024

Abstract
Objective
The importance of research cannot be overemphasized. Research findings serve as a guide for the enactment of development policies and legislation. However, not all members of the target population willingly participate in a study. The current study explored the reasons why some individuals refused to partake in inclusive education research in a developing country, Ghana. The journaling helped to capture the voices of 87 participants who refused to take part in a larger inclusive education survey study.

Results
The study found that the participants did not take part in the research because of reasons such as lack of financial gain, bad experience with previous research, lack of direct benefit, and lack of time. The findings of the study and its implication for policymaking in Ghana and research studies in sub-Saharan Africa are discussed.
Functional identification of CCR1 gene in apple (Malus halliana) demonstrates that it enhances saline-alkali stress tolerance
Authors: Wang Xiu , Zhang Zhong-Xing , Wang Wan-Xia , Li Si-Tian , Li Juan-Li , Wang Yan-Xiu 
Published: March 2024

Abstract
Background
Lignin is a complex aromatic polymer that plays an important biological role in maintaining plant structure and defending plants against biotic and abiotic stresses. Cinnamoyl-CoA reductase (CCR) is a key enzyme involved in the lignin synthesis-specific pathway and regulates lignin biosynthesis and accumulation.

Methods
Based on transcriptome data, MhCCR1, which was significantly induced by saline-alkali stress, was cloned from Malus halliana. The physicochemical properties, evolutionary relationships and cis-acting elements were analyzed. We obtained transgenic materials by heterologous transformation of MhCCR1 into Arabidopsis thaliana and tobacco, as well as homologous transformation into apple callus, and characterized their saline-alkali stress resistance by a series of physiological and biochemical experiments. And yeast two-hybridization technique was applied to screen and validate the interacting proteins.

Results
We found that overexpression of MhCCR1 enhanced the tolerance of A. thaliana, tobacco and apple calli under saline-alkali stress, and caused a variety of physiological and biochemical changes. As compared to the wild type, the transgenic plants showed better growth, higher lignin, chlorophyll and proline contents, lower conductivity and MDA content, and significant increase in antioxidant enzyme activities (SOD, POD, CAT) in the transgenic lines under stress condition. In addition, expression of saline-alkali stress-related genes in overexpressed A. thaliana were also higher than in WT, including the antioxidant genes, the Na+ transporter genes, and the H+-ATPase genes, while expression of the K+ transporter genes displayed opposite changes. Meanwhile, the expression levels of genes related to lignin synthesis, AtPAL1, AtCOMT, AtC4H, At4CL1, and AtCCOAOMT, were also significantly up-regulated. At last, the Y2H experiment confirmed the interaction between MhCCR1 and MhMYB4, MhMYB1R1, MhHXK, and MhbZIP23 proteins.

Conclusions
These results suggest that MhCCR1 may play a positive regulatory role in saline-alkali tolerance of transgenic lines by regulating the lignin content, osmoregulatory substances, chlorophyll content, antioxidant enzyme activities, and genes related to saline-alkali stress, thus providing excellent resistance genes for the stress-responsive regulatory network of apples, and providing a theoretical basis for the cultivation of saline and alkali-resistant apple varieties.

Graphical Abstract
Theorising quantified credibility in the age of big data: a case of China’s Social Credit System
Authors: Raghunath Nilanjan 
Published: March 2024

AbstractIn this paper, I theoretically examine the concept of quantified credibility in sociology. I argue that quantified credibility has components of status, reputation, and trust, which are arbitrations of rankings of individuals, public and private institutions to determine their trustworthiness, legitimacy, and access to resources. To illustrate the above, this paper provides an in-depth analysis of China’s Social Credit System (SOCS), as it is developing into one of the largest and comprehensive data systems in the world.
(In)Security Theater
Authors: Lever Carla 
Published: March 2024

Abstract
Spectacle is central to protest efficacy, yet the term performance has a history of being used pejoratively to discredit both protestors and their causes. This deflects analysis from the ubiquitous tactical performances enacted by institutional representatives themselves. Following Cape Town mayor Dan Plato's 2020 dismissal of an eviction resistance on the grounds that it was a “staged act,” this article identifies various repertoires of performative intimidation enacted by local authorities against South African land occupiers during 2019–22. These staged acts were strategically performed with a dual audience in mind: one direct and the other, necessarily, oblique. In recasting such repertoires as rational actions in response to radical acts, municipal officials control the means of identifying and critiquing cynical public performance.
Empowerment of Village Owned Enterprises through E-Commerce Information Technology in Increasing the Economy of Sipodeceng Village Communities
Authors: Razak Muhammad Rais Rahmat , Mursalat Aksal , Sellang Kamaruddin , Syarifuddin Rifni Nikmat , Ramadhan Muhammad Rohady , Irwan Muh. , Asra Reza , Bibin Muhammad , Said Sunandar , Andreani Andi Riska , Latif Adam , B Sofyan , Syam Syaiful Bahri , Aksan Muhammad 
Published: March 2024

Background: This activity aims to increase the role of Bumdes Padaidi Sipodeceng through e-commerce information technology based on the Bumdes Sipodeceng Store application in improving the economy of the people of Sipodeceng Village.
Contribution: This activity improves the welfare of the people of Sipodeceng Village through e-commerce information technology.
Method: The method of this activity includes Socialization of the implementation of activities, Counseling by explaining the e-commerce information technology marketing model (BUMDES Sipodeceng Store), training and mentoring the use of information technology for BUMDES partner groups, carrying out assistance, as well as monitoring and evaluation.
Results: Training and mentoring activities based on pre-test and post-test data analysis have positive implications for 3 parameters: knowledge from 42.14 to 89.14%, skills from 35.9% to 90.12%, and motivation from 63.2% to 93 .2%. From these data, an analysis of the effectiveness of these 3 parameters is carried out, the values of which are knowledge at 81%, skills at 85%, and motivation at 79%. These three numbers indicate that community service activities are effective because the value is above 50%.
Conclusion: From these activities, it can be concluded that e-commerce information technology at BUMDES Padaidi Sipodeceng is still very much needed to increase the role of BUMDES in community empowerment.
Research on teaching mode driven by smart education concept
Authors: Liu Li , Xu Chonghao 
Published: March 2024

Background: The rapid development of science and technology, the Internet, big data, artificial intelligence and other technologies have had a huge impact on all walks of life in the society.With the continuous deepening of modern information technology such as artificial intelligence, big data, and the Internet of Things in education and teaching.
Contribution: Smart education can promote the transformation of education concepts, reshape the space and structure of education and learning, promote fundamental changes in the level and structure of the education system, and lead the education system to overall innovation.
Method: Propose a Smart education realizations teaching model that can bring prerequisites for the upgrading of digital education.
Results: Smart education is a high level form of education modeling and an essential requirement for education information to enter a new stage.
Conclusion: The proposed model can effectively address the shortcomings of traditional teaching methods and has effectiveness.
Adapting History Education for the 21st Century: Integrating Technology and Critical Thinking Skills
Authors: Lee Bih Ni 
Published: March 2024

Background: In the 21st century, the field of education is undergoing significant transformations due to advancements in technology and the growing emphasis on critical thinking skills. Adapting history education to meet the needs of this digital era requires integrating technology into instructional practices while fostering critical thinking abilities.This approach allows students to engage with primary sources, explore diverse perspectives, and develop the analytical skills necessary for understanding and interpreting complex historical events.
Contribution: The integration of technology and critical thinking skills in history education contributes to a more dynamic and engaging learning experience for students in the 21st century. It empowers students to access primary sources, analyze multiple perspectives, and develop the essential skills needed for critical analysis and interpretation of historical events.
Method: The synthesis method is a comprehensive approach to analyzing and integrating research findings on adapting history education for the 21st century through the integration of technology and critical thinking skills. By systematically reviewing and synthesizing relevant studies, it allows for the identification of common themes, trends, and gaps in the literature, providing a cohesive and nuanced understanding of the topic and informing best practices for educators in this field..
Results: The results of integrating technology and critical thinking skills in history education show improved student engagement, motivation, and understanding of historical concepts. Students also develop enhanced critical thinking abilities, such as analyzing evidence, evaluating sources, and constructing well-reasoned arguments, which prepare them for active participation in the complexities of the 21st century
The hidden problem of proteins
Authors: Nixon Jenny 
Published: March 2024

Jenny Nixon looks at the effect of residual proteinaceous material on the reprocessing of dental instruments. Aim To educate readers about protein and its place within the decontamination process and to explain why alcohol is not an effective cleaner for dental instruments. The article will also aim to make readers aware of pre-treatment solutions and their effectiveness with dental decontamination. Objectives Readers will understand the importance of protein removal from dental instruments. Readers will understand why alcohol is not an effective cleaner for dental instruments. Readers will be aware of how pre-treatment solutions contribute to effective decontamination protocols.
Human being in state security policy - theoretical approaches
Authors: Pieczywok Andrzej 
Published: March 2024

Cel pracyOpracowanie ma na celu ukazanie człowieka w polityce bezpieczeństwa państwa, a także w nurcie głównych ujęć teorii bezpieczeństwa: teorii realistycznej, liberalnej, konstruktywistycznej i behawioryzmu oraz wskazanie głównych czynników wpływających na jego zachowania antyspołeczne.Materiał i metodyW publikacji wykorzystano kilka metod badawczych, były to: analiza dokumentów źródłowych i literatury badań, analiza systemowa i formalnoprawna oraz instytucjonalna. Określając człowieka w polityce bezpieczeństwa państwa stwierdzono przy tym jego skłonność do zachowań antyspołecznych, wskazano też na kilka teorii bezpieczeństwa podkreślających podmiotowość człowieka w organizacji bezpieczeństwa narodowego i międzynarodowego.WynikiProwadzone analizy wskazują, że człowiek jest głównym podmiotem polityki bezpieczeństwa państwa, narażony jest na szereg zagrożeń, które uzależnione są od jego natury i kryzysu egzystencji, a także czynników zewnętrznych (środowiska, innych osób). Warto zauważyć, że idee bezpieczeństwa człowieka osadzone są nie tylko w polityce bezpieczeństwa państwa, ale także w teoriach naukowych (bezpieczeństwa), a elementem ich analizy jest identyfikacja zagrożeń oraz skłonność istoty ludzkiej do zachowań antyspołecznych.WnioskiW wyniku zgromadzonego materiału i prowadzonych analiz, Autor wskazał na najważniejsze nurty bezpieczeństwa strukturalnego w teoriach naukowych, rozszerzając niektóre pola poznawcze i dokonując pewnych ujednoliceń w stosunku do bezpieczeństwa personalnego. Wartość tych teorii głównie jest ukierunkowana na bezpieczeństwo państw i jego struktur, społeczeństw, a zdecydowanie mniej na bezpieczeństwo personalne człowieka.
Building partnerships for the development of language and reading skills of children with special developmental needs in the opinion of parents and teachers
Authors: Kuracki Kamil 
Published: March 2024

Cel pracyBadania ukierunkowane zostały na rozpoznanie doświadczeń rodziców i nauczycieli dzieci ze specjalnymi potrzebami rozwojowym w zakresie budowania partnerstwa na rzecz rozwijania umiejętności językowych i czytelniczych dzieci. Celem badań było również rozpoznanie dostrzeganych przez rodziców i nauczycieli trudności, szans i potrzeb związanych z podejmowaniem współpracy zorientowanej na organizację wczesnych inicjacji czytelniczych.Materiał i metodyBadania z wykorzystaniem metody zogniskowanych wywiadów grupowych przeprowadzono w niewielkich grupach rodziców (N=25) oraz nauczycieli (N=26) dzieci ze specjalnymi potrzebami rozwojowymi w okresie wczesnego i średniego dzieciństwa. Teren badań obejmował placówki przedszkolne/oddziały przedszkolne na terenie województwa mazowieckiego. Analizę zgromadzonego materiału badawczego przeprowadzono w orientacji jakościowej.WynikiDoświadczenia rodziców i nauczycieli obejmują wiele zróżnicowanych przedsięwzięć, które oceniane są przez obie badane grupy jako udane i satysfakcjonujące, choć niepozbawione trudności ujawniających się na poziomie organizacyjnym, komunikacyjnym czy też kompetencyjnym. Obie badane grupy zarysowały w formie postulatów konkretne kierunki zmian, które mogą zintensyfikować i usprawnić podejmowane we współpracy działania na rzecz wczesnej alfabetyzacji dzieci ze specjalnymi potrzebami rozwojowymi.WnioskiPodejmowana na linii dom rodzinny - przedszkole/szkoła- inne placówki współpraca, ukierunkowana na podejmowanie zadań obszaru wczesnej alfabetyzacji dzieci ze specjalnymi potrzebami rozwojowymi stanowi ważne zadanie współczesnej edukacji. Jej efektywność związana jest jednak z koniecznością promowania idei partnerstwa edukacyjnego i tworzenia warunków do wielopodmiotowej dyskusji nad możliwościami wdrażania jej w życie.
Strongyloidiasis in Auckland: A ten-year retrospective study of diagnosis, treatment and outcomes of a predominantly Polynesian and Fijian migrant cohort
Authors: Cutfield Tim , Motuhifonua Soana Karuna , Blakiston Matthew , Bhally Hasan , Duffy Eamon , Lane Rebekah , Otte Erik , Swager Terri , Taylor Amanda Maree , Playle Veronica 
Published: March 2024

Background
Strongyloides stercoralis is not endemic in Aotearoa New Zealand (AoNZ). However, approximately one third of Auckland residents are born in endemic countries. This study aimed to describe the epidemiology and management of strongyloidiasis in Auckland, with a focus on migrants from Pacific Island Countries and Territories.

Methods
This study retrospectively reviewed clinical, laboratory and pharmacy records data for all people diagnosed with strongyloidiasis in the Auckland region between July 2012 and June 2022. People with negative Strongyloides serology were included to estimate seropositivity rate by country of birth.

Findings
Over ten years, 691 people were diagnosed with strongyloidiasis. Most diagnoses were made by serology alone (622, 90%). The median age was 63 years (range 15–92), 500 (72%) were male, and the majority were born in Polynesia (350, 51%), Fiji (130, 19%) or were of Pasifika ethnicity (an additional 7%). Twelve participants (1.7%) had severe strongyloidiasis at diagnosis. The total proportion treated with ivermectin was only 70% (484/691), with no differences between immunocompromised and immunocompetent participants, nor by ethnicity. The outcome of treatment (based on a combination of serology and/or eosinophilia and/or stool microscopy) could only be determined in 50% of the treated cohort. One participant failed treatment with ivermectin, experiencing recurrent strongyloidiasis, and another participant died in association with severe strongyloidiasis. The rate of ‘positive’ Strongyloides serology was highest among participants born in Samoa (48%), Fiji (39%), and Southeast Asian countries (34%).

Interpretation
Strongyloidiasis was common and under-treated in Auckland during the study period. Clinicians should have a low threshold for considering strongyloidiasis in migrants from endemic countries, including Polynesia and Fiji.
Outcome benefits of upfront cytoreductive nephrectomy for patients with metastatic renal cell carcinoma: An analysis of the TriNetX database
Authors: Lai Gu-Shun , Li Jian-Ri , Wang Shian-Shiang , Chen Chuan-Shu , Yang Chun-Kuang , Lin Chia-Yen , Hung Sheng-Chun , Chiu Kun-Yuan , Yang Shun-Fa 
Published: March 2024

Background
The role of upfront cytoreductive nephrectomy remains debatable in the present era of tyrosine kinase inhibitors and immune checkpoint inhibitors. Here, we aimed to evaluate the outcomes of metastatic renal cell carcinoma patients treated with upfront CN and modern systemic therapies.

Methods
Using the TriNetX network database, we identified patients, in the period from 2008 to 2022, who were diagnosed with metastatic renal cell carcinoma, receiving first-line systemic therapies with tyrosine kinase inhibitors or immune checkpoint inhibitors. Their overall survivals were evaluated using the Kaplan-Meier method as well as multivariable regressions.

Results
We identified 11,094 patients with metastatic renal cell carcinoma. Of them, 2,914 (43%) patients in the tyrosine kinase inhibitor cohort (n = 6,779), and 1,884 (43.7%) in the immune checkpoint inhibitors cohort (n = 4315) underwent upfront cytoreductive nephrectomy. Those receiving upfront cytoreductive nephrectomy showed survival advantages with either tyrosine kinase inhibitor (Hazard ratio 0.722, 95% Confidence interval 0.67–0.73, p<0.001) or immune checkpoint inhibitors (Hazard ratio 65.1, 95% Confidence interval 0.59–0.71, p<0.001). In multivariable analysis, upfront cytoreductive nephrectomy was a factor for improved OS in both cohorts: tyrosine kinase inhibitors (Hazard ratio 0.623, 95% Confidence interval 0.56–0.694, p<0.001) and immune checkpoint inhibitors cohort (Hazard ratio 0.688, 95% Confidence interval 0.607–0.779, p<0.001).

Conclusions
Upfront cytoreductive nephrectomy was associated with an improved overall survival for patients with metastatic renal cell carcinoma receiving either first-line tyrosine kinase inhibitors or immune checkpoint inhibitors. Our results support a clinical role of upfront cytoreductive nephrectomy in the modern era.
The Impacts of COVID-19 Restrictions on Quality Adjusted Life Years (QALY): Heterogeneous effects and post-pandemic recovery
Authors: Atal Raimundo , Bedregal Paula , Carrasco José A. , González Felipe , Harrison Rodrigo , Vizcaya Cecilia 
Published: March 2024

Objectives
Estimate the effects of non-pharmacological interventions used to prevent the spread of COVID-19 on the quality of life, measured by Quality Adjusted Life Years (QALYs).

Methods
A survey on 1,506 heads of households from Chile in May of 2022. Respondents were asked basic socioeconomic questions and a version of the EQ-5D-5L questionnaire that was used to calculate the evolution of HRQoLs. Comparisons of means in HRQoLs measures before the pandemic, at the peak of restrictions, and at the moment of the survey were performed.

Results
The average HRQoL of the population before the pandemic was similar to other countries in the region (0.96). At the peak of restrictions (June 2020–August 2021), the average HRQoL decreased to 0.87 (-9%). At the time of survey (May 2022), the average HQRoL was 0.91 (4%). Assuming the recovery trend continued, pre-pandemic HRQoLs would be reached by January 2024. Altogether, the pandemic would have reduced QALYs by 0.2 in average. The effect is larger and the recovery slower among women. Our estimates imply that the restrictions to manage the pandemic came at a cost of 2.4 months of life years for the average (surviving) person, 1.8 months for men and 3.4 for women.

Conclusions
Our results suggest that COVID-19 had worse effects on life quality than previously thought. These effects are more significant among women than among men. Efforts to improve life quality and speed up its recovery could have large positive consequences for the population.