bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthèse d'éthers diéthylamino éthyliques de bibenzofurannes et de bis‐benzofuryl cétones, comme analogues pharmacochimiques de la Tilorone
Authors: Guillaumel Jean , Royer René 
Published: March 2009

AbstractLes éthers diéthylaminoéthyliques de divers bis‐(Bz‐hydroxy) bibenzofurannes sont préparés, soit à partir d'alcool hydroxy‐2‐méthoxy‐5 benzylique, soit à partir d'acides benzofuranne carboxyliques. Les éthers correspondents de bis‐(Bz‐hydroxy benzofuryl‐2) méthanones le sont à partir d'aldéhydes méthoxy salicyliques.
Isomers and aza‐analogues of indoxyl containing nitrogen at a ring‐fusion position: Coupling reactions with electrophiles and attempted oxidations
Authors: Katritzky Alan R. , Caster Kenneth C. , Rubio Olga , Schwarz Otto 
Published: March 2009

AbstractDerivatives of four series of compounds derived from isomers of indoxyl with the nitrogen at the bridgehead and two further series of aza‐analogues are prepared and their absorption properties studied.
The synthesis of 3‐hydroxymethyldibenzo[b,f]thiepin 5,5‐dioxide, a prostaglandin antagonist
Authors: Hands David , Marley Hugh , Skittrall Stephen J. , Wright Stanley H. B. , Verhoeven Thomas R. 
Published: March 2009

AbstractAn economic synthesis of 3‐hydroxymethyldibenzo[b,f]thiepin 5,5‐dioxide, a novel prostaglandin antagonist, is described. The key step in the synthesis is the formation of a carboxyphenylacetic acid by carboxylation of a toluic acid dianion, followed by cyclisation to the tricyclic ketone. Readily available starting materials are used in the synthesis and conditions have been found at each stage to give pure intermediates, requiring little purification, in high yield.
The preparation of selected benzopyrano[3,4‐b]pyrazoles by the condensation of c(α), n‐dilithiocarboalkoxyhydrazones and salicylate esters
Authors: Huff Ann M. , Beam Charles F. 
Published: March 2009

AbstractSelected C(α),N‐dilithiocarboalkoxyhydrazones were prepared in an excess of lithium diisopropylamide (LDA) and condensed with a variety of salicylate esters to give intermediates that were acid‐cyclized to benzopyrano[3,4‐b]pyrazoles (coumarin‐pyrazoles).
A novel synthesis of benzofuran and related compounds. I. The vilsmeier reaction of phenoxyacetonitriles
Authors: Hirota Takashi , Fujita Hiroko , Sasaki Kenji , Namba Tetsuto , Hayakawa And Shohei 
Published: March 2009

AbstractA novel synthesis of 2‐benzofurancarboxylic acid derivatives by the Vilsmeier reaction of phenoxyacetonitriles is described.
Pesticidal Mannich Bases Derived from Isatinimines
Authors: Ram Vishnu J. , Mishra L. , Pandey H. N. , Vlietinck A. J. 
Published: March 2009

AbstractMannich bases from isatinimines and isatin hydrazones are synthesized for evaluation of their pesticidal activities. Among all the prepared Mannich bases only N‐dimethylaminomethyl‐3‐(p‐bromophenyl)iminoindol‐2‐one exhibited herbicidal activity in pre‐ and post‐emergent tests.
A convenient synthesis and antifungal activity of 1‐aryl‐1H‐ and 1‐aryl‐3‐heteroaryl‐1H‐pyrazolo[3,4‐b]quinoxalinesA Convenient Synthesis and Antifungal Activity
Authors: Kurasawa Yoshihisa , Muramatsu Muneto , Yamazaki Kaoru , Tajima Setsuko , Okamoto Yoshihisa , Takada Atsushi 
Published: March 2009

AbstractNovel 1‐aryl‐1H‐ and 1‐aryl‐3‐heteroaryl‐1H‐pyrazolo[3,4‐b]quinoxalines (flavazoles)9a‐c, 12, 13were synthesized from 3‐methyl‐2‐oxo‐1,2‐dihydroquinoxaline 5 and the 3‐triazolylmethylene‐2‐oxo‐1,2,3,4‐tetrahydroquinoxaline 6, respectively,viaa facile hydrazone synthesis using aryl diazonium salts. Some of the above flavazoles and their related compounds exhibited the antifungal activity in some extent. The above results are described.
A facile synthesis of 1‐aryl‐3‐heteroaryl‐1H‐pyrazolo[3,4‐b]quinoxalines and related compounds with antifungal activitySynthesis of 1‐Aryl‐3‐heteroaryl‐1H‐pyrazolo[3,4‐b]quinoxalines
Authors: Kurasawa Yoshihisa , Muramatsu Muneto , Yamazaki Kaoru , Tajima Setsuko , Okamoto Yoshihisa , Takada Atsushi 
Published: March 2009

AbstractThe novel 1H‐pyrazolo[3,4‐b]quinoxalines (flavazoles) 9–15 were synthesized from 3‐methoxycarbonylmethylene‐2‐oxo‐1,2,3,4‐tetrahydroquinoxaline 6 via a convenient hydrazone synthesis, and these flavazoles were clarified to have the antifungal activity.
Pyridoannelation of hindered ketones via their nitrogen derivatives. Synthesis of 5,6,7,8‐tetrahydro‐8,9,9‐trimethyl‐5,8‐methanoquinolines from (+)‐camphor
Authors: Chelucci Giorgio , Delogu Giovanna , Gladiali Serafino , Soccolini Francesco 
Published: March 2009

AbstractThe transformation of (+)‐camphor into (+)‐8,9,9‐trimethyl‐ and (+)‐2,8,9,9‐tetramethyl‐5,6,7,8‐tetrahydroquinolines 1 and 2 has been accomplished by three different procedures based on the elaboration of imino or enamino intermediates. The values of the rotatory powers for both the compounds are reported.
Synthesis of novel pyrimidine nucleoside analogues
Authors: De Napoli Lorenzo , Mayol Luciano , Piccialli Gennaro , Rossi Mosé , Santacroce Ciro 
Published: March 2009

AbstractTwo new tetrazolopyrimidinedeoxynucleosides were synthesized and their physico‐chemical data are described. Results of preliminary analyses of their biological properties are also reported.
Synthesis of some 7‐substituted‐2,4,8(1H,3H,7H)pyrimido[5,4‐d]pyrimidinetriones
Authors: Pendergast William , Hall William R. 
Published: March 2009

AbstractA synthesis of 2,4,8‐pyrimido[5,4‐d]pyrimidinetriones under mild conditions from ethyl 5‐ethoxymethyleneamino‐orotate allows the introduction of a variety of substituents regiospecifically into the 7‐position. The 7‐methyl and 7‐benzyl derivatives were methylated with trimethyl phosphate to the 1,3,7‐trialkyl derivatives.
Synthesis of some 5‐Aryl‐4,5‐dihydro[1]benzoxepin‐3(2H)‐ones and 5‐aryl‐5,6,8,9‐tetrahydro‐7H‐benzocyclohepten‐7‐ones from benzoxepinoisoxazolone and benzocycloheptaisoxazolone derivatives
Authors: Deshayes Christian , Pujol Bernard , Gelin Suzanne 
Published: March 2009

AbstractSome 5‐aryl‐4,5‐dihydro[1]benzoxepin‐3(2H)‐ones and 5‐aryl‐5,6,8,9‐tetrahydro‐7H‐benzocyclohepten‐7‐ones were synthesized by hydrogenolytic cleavage of the isoxazole ring of 4‐aryl‐3‐oxo‐3,3a,4,10‐tetrahydro[1]‐benzoxepino[3,4‐c]isoxazoles or 4‐aryl‐3‐oxo‐3a,4,9,10‐tetrahydro‐3H‐benzo[4,5]cyclohepta[1,2‐c]isoxazoles which in turn were prepared from ethyl 3‐oxo‐4‐phenoxybutanoate or ethyl 3‐oxo‐5‐phenylpentanoate by simple methods.
Syntheses and conformations of some cyclic hydroxamates. X‐Ray crystal structure of 2‐(p‐nitrobenzoyl)tetrahydro‐2H‐1,2‐oxazine
Authors: Johnson James Elver , Hodzi Richard , Todd Susan L. , De Meester Patrice , Chu Shirley S. C. 
Published: March 2009

AbstractAlkylation of potassium p‐nitrobenzohydroxamate with 1,4‐dibromobutane gave 2‐(p‐nitrobenzoyl)tetrahydro‐2H‐1,2‐oxazine (3). The X‐ray crystal structure of 3 has been determined. The crystals are monoclinic, space group P21/n with a = 6.749(1), b = 7.644(1), c = 21.557(2)Å, β = 98.89(1), V = 1098.8(2)Å3 and Z = 4. The structure, which was refined to R = 0.039 using 1340 observed reflections, shows the oxazine and carbonyl oxygen atoms trans to each other. Alkylation of potassium benzohydroxamate with 1,3‐dibromobutane gave a mixture of 3‐methyl‐2‐benzoyloxazolidine (4) and 5‐methyl‐2‐benzoyloxazolidine (5). The 1H and 13C nmr spectra of the mixture of 4 and 5 indicates that these cyclic hydroxamates exist predominantly in the s‐trans conformation.
Electrophilic hydrogen‐deuterium exchange of some deactivated pyrroles
Authors: Gilow Helmuth M. , Hong Yoon H. , Millirons Paula L. , Snyder Richard C. , Casteel William J. 
Published: March 2009

AbstractThe rate coefficients and partial rate factors for the hydrogen‐deuterium exchange of some 1‐substituted pyrroles (1‐substituents = ‐COCH3, ‐ COC6H5, ‐SO2CH3, ‐SO2CF3, ‐N(CH3)3, ‐NH(CH3)2, ‐SO2C6H5) in deuterated trifluoroacetic acid have been determined. In all cases the rate of exchange is faster at the 2‐position. Similarly, the hydrogen‐deuterium exchange of some pyrroles with electron withdrawing substituents in the 2‐position indicate a relative reactivity of 4→ 5→ 3‐position with the selectivity being greatest for the more electron withdrawing groups. A nitro group in the 3‐position of pyrrole shows a relative reactivity of 5→2→4‐position for the hydrogen‐deuterium exchange in deuterated trifluoroacetic acid. A linear correlation is observed for the log of the rate coefficient of the hydrogen‐deuterium exchange at the 4‐position of some 2‐substituted pyrroles and the difference in the calculated energy of formation of the pyrrole and the corresponding 4‐deuterated cation.
Cross‐coupling reaction of chloropyrazines with ethylenes
Authors: Akita Yasuo , Noguchi Tomofumi , Sugimoto Michinobu , Ohta Akihiro 
Published: March 2009

AbstractVarious chloropyrazines and their N‐oxides were submitted to the cross‐coupling reaction with ethylenes, such as styrene, ethyl acrylate and acrylonitrile. While the chloro‐phenylpyrazines and 2‐chloropyrazine 1‐oxides were slugglish in this reaction system, the expected products were obtained from almost all the 2‐chloro‐3,6‐dialkylpyrazines and their 4‐oxides in moderate to good yields.
Derivatives of benzo[4,5]cyclohepta[1,2‐b]thiophene. 4. Synthesis of 1‐(9,10‐dihydro‐4H‐benzo[4,5]cyclohepta[1,2‐b]thiophen‐4‐yl)‐3‐alkylaminoazetidines
Authors: Jiménez Amelia , Vega Salvador 
Published: March 2009

AbstractThirteen 1‐(9,10‐dihydro‐4H‐benzo[4,5]cyclohepta[1,2‐b]thiophen‐4‐yl)‐3‐alkylaminoazetidines 11 have been synthesized in three steps from 4‐amino‐9,10‐dihydro‐4H‐benzo[4,5]cyclohepta[1,2‐b]thiophene (6), which was obtained from the reduction of either 4‐azido 4 or 4‐hydroxyimino 5 derivatives. All the compounds have been evaluated as potential antidepressive agents.
Reaction of 6‐ethylamino‐3‐methyluracil with nitrobenzenes
Authors: Harayama Takashi , Jinno Hideto , Tezuka Yasuhiro , Yoneda Fumio 
Published: March 2009

AbstractReaction of 6‐ethylamino‐3‐methyluracil (1) with nitrobenzenes in hexamethylphosphoric triamide gave isoalloxazines in 3.8–18 percent yield. In the presence of potassium carbonate, reaction of 1 with o‐fluoronitrobenzene afforded 5‐substituted uracil 3 in moderate yield.
Synthesis of novel furan and thiophene PAH'S related to acephenanthrylene
Authors: Lee‐Ruff Edward , Chung Ying‐Sheng 
Published: March 2009

AbstractThe total syntheses of furan and thiophene PAH's related to acephenanthrylene are reported. Cyclobutanones which were obtained by [2 + 2] addition of ketenes with 2,3‐dihydrofuran or 2,3‐dihydrothiophene regioselectively could be converted into angular PAH skeleton molecules by rearrangements with polyphosphoric acid. 2,3‐Dichloro‐5,6‐dicyanobenzoquinone was applied for aromatization to achieve the formation of PAH's.
Pyrrolopyridine analogs of nalidixic acid. 2. Pyrrolo[3,4–6]pyridines
Authors: Toja Emilio , Kettenring Jurgen , Goldstein Beth , Tarzia Giorgio 
Published: March 2009

AbstractThe synthesis of the new 1‐ethyl‐5,6‐dimethyl‐7‐(4‐methyl‐1‐piperazinyl)‐1,4‐dihydro‐4‐oxo‐1H‐pyrrolo[3,4‐b] pyridine‐3‐carboxylic acid (12) was carried out using ethyl 4‐amino‐2‐methyipyrrole‐3‐carboxylate as the starting material. Compound 12 was devoid of antibacterial activity in vitro.
The synthesis of two monosubstituted meso‐tetraphenylporphine sulfonates
Authors: Sun Yizhen , Martell Arthur E. , Chen Dian , Macfarlane Ronald D. , Mcneal Catherine J. 
Published: March 2009

AbstractThis paper describes the synthesis and characterization of two novel meso‐tetrakis(4‐sulfophenyl)‐21H,‐23H‐porphine (TPPS4) derivatives in which one of the phenyl rings is substituted with an anticancer agent. Several advantages of monosubstitution are pointed out: the higher efficiency of synthetic steps involving the derivatization of one, rather than several, functional group per porphyrin molecule, and the greater solubility and ease of purification of monosubstituted tetraphenylporphines. The new compounds have 5‐fluorouracil and cis dichloroethylenediamineplatinum (cis‐platinum) substituted in the meta positions of one of the phenyl rings in TPPS4. The palladium analog of the cis‐platinum dervative which contains two Pd(II) atoms per molecule ‐ one coordinated with the ethylenediamine moiety, and the other coordinated at the center of the porphyrin ring, was also prepared.
The synthesis of dimethoxy[1]benzothieno[2,3‐c]quinolines
Authors: Pakray Sudabeh , Castle Raymond N. 
Published: March 2009

AbstractA series of dimethoxy[1]benzothieno[2,3‐c]quinolines have been prepared by photocyclization of the appropriate N‐phenyl‐3‐chlorobenzo[b]thiophene‐2‐carboxamides. The lactams obtained were converted into the thiolactams and their S‐methyl derivatives. The lactams were also converted into the corresponding chloro derivatives which were catalytically dechlorinated into the dimethoxy[1]benzothieno[2,3‐c]quinolines. The latter compounds were converted into the N‐methyl quaternary salts.
Synthesis of heterocyclic compounds. LI. Schiff bases of ethyl 2‐aminofurancarboxylates
Authors: Ciller J. A. , Seoane C. , Soto J. L. , Yruretagoyena B. 
Published: March 2009

AbstractDiaryl‐ and Alkylaryl‐substituted 2‐aminofurancarboxylates have been obtained as Schiff bases 5,6 by cyclization of 2‐ethoxycarbonyl‐4‐oxonitriles 3,4; which result from hydrogen cyanide addition to ethyl α‐acylcinnamates 1,2.
Synthesis of some isomeric 4,11‐dihydro‐5H‐[1]benzoxocino[4,3‐d] or [3,4‐c]isoxazol‐5‐ones and isomeric 4,5,10,11‐tetrahydrobenzo[5,6]‐cycloocta[2,1‐d] or [1,2‐c]isoxazol‐5‐ones
Authors: Deshayes Christian , Chabannet Michel , Gelin Suzanne 
Published: March 2009

AbstractThe title compounds were prepared by acid‐catalyzed cyclization of aryloxymethyl‐ or (2‐arylethyl)‐4‐carboxymethylisoxazoles which in turn were synthesized from aryloxymethyl‐ or (2‐arylethyl)isoxazole‐4‐carboxylic acids by Arndt‐Eistert homologation.
Synthesis and stereochemistry of tetrahydroprotoberberine derivatives
Authors: Badia D. , Domínguez E. , Iriondo C. 
Published: March 2009

AbstractA series of 5‐hydroxytetrahydroprotoberberines has been prepared from 3‐aryltetrahydroisoquinoline derivatives via successive N‐alkylation, oxidation and cyclization in acidic media. The relative configurations of the resulting diastereomeric 5‐hydroxytetrahydroprotoberberines are reported.
Electroorganic synthesis. Reductive alkylation of functionalized 1,2‐dithiole‐3‐thiones
Authors: Darchen André , Berthelot Pascal , Vaccher Claude , Viana M. Nazareth , Debaert Michel , Burgot Jean Louis 
Published: March 2009

AbstractTwo‐electron reduction of some substituted 1,2‐dithiole‐3‐thiones 1 followed by alkylation of the dianionic intermediates leads through electrosynthesis to mixture of Z and E isomers of the corresponding substituted alkyl‐(3‐thioalkyl)‐2‐propenedithioates 2, 3 in satisfactory yield. The structure of those products was established by 13C and 1H nmr and mass spectroscopy. The isomers ratios were determined by nmr spectroscopy.
Synthesis of 4‐(2‐acetoxyethoxymethyl)‐6‐methyl‐1,2,4‐triazin‐3(4H)‐one 1‐oxide as thymidine analogue
Authors: Banijamali Ali R. , Foye William O. 
Published: March 2009

AbstractAlkylation of the sodium salt and the trimethyl silylated derivatives of 6‐methyl‐1,2,4‐triazin‐3(4H)‐one 1‐oxide with chloromethoxyethyl acetate, n‐hexyl chloride and benzyl bromide gave the 4‐substituted products. However, attempts to achieve the ring closure of N4‐(2‐acetoxyethoxymethyl)thiosemicarbazide with bicarbonyl compounds to the corresponding as‐triazines under different reaction conditions was not possible without disruption of the acetoxyethoxymethyl moiety. Although the as‐triazine nucleoside analog II did not show antileukemic activity, this and other 4‐alkylated as‐triazine 1‐oxides revealed good growth inhibitory effects against a representative spectrum of microorganisms.
Synthesis of 5‐phenylnaphtho[1,2‐b]benzofuran by ambident alkylation of 1‐naphthol
Authors: Campaigne E. , Weddleton Richard F. 
Published: March 2009

AbstractReaction of 1‐naphthol with 2‐chlorocyclohexanone in alkaline alcohol gave as the major product 5‐(2′‐oxocyclohexyl)‐7,8,9,10‐tetrahydronaphtho[1,2‐b]benzofuran (1), which could be converted to the title compound 5 by reduction and dehydrogenation. This product arises from ambident alkylation of 1‐naphthol at the 2‐and 4‐positions. Via the 2′‐oxocyclohexyl ether, 5 was also synthesized from 4‐phenyl‐1‐naphthol.
Synthesis of 3‐(2‐benzothiazolylthio)propanenitrile and related products
Authors: D'Amico John J. , Suba Lydia , Ruminski Peter G. 
Published: March 2009

AbstractThe reaction of 2‐mercaptobenzothiazole, 2‐mercaptobenzoxazole or 5‐chloro‐2‐mercaptobenzothiazole with either acrylonitrile or acrylamide under basic conditions afforded the N‐cyanoethylated products 1, 2 and 3 or the N‐amidoethylated products 4, 5 and 6, respectively. The reaction of the sodium salts of the same thiazolethiols with 3‐chloropropionitrile furnished a mixture containing the N‐cyanoethylated products 1, 2 and 3 and the unknown S‐cyanoethylated products 7, 8 and 9, respectively. Whereas, substituting 3‐chloropropionamide for 3‐ chloropropionitrile in the same reaction gave only the S‐substituted products 10, 11, and 12, respectively. The treatment of 10, 11 or 12 with phosphorus oxychloride or thionyl chloride in DMF afforded 7, 8 and 9 in excellent yields. Possible mechanisms and supporting nmr data are discussed.
Synthesis of variants of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine
Authors: Chu Shih‐Hsi , Chen Zhi‐Hao , Weng Zum‐Yao , Rowe Elizabeth C. , Chu Edward , Chu Ming‐Yu Wang 
Published: March 2009

AbstractA number of variations and derivatives of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacy‐clouridine), potent inhibitors of uridine phosphorylase were synthesized for evaluation as potential cancer chemotherapeutic agents. (“Acyclo” = 2′‐hydroxymethoxymethyl‐). These included a modification of the methylene group at N‐1, esters of the terminal hydroxyl of the acyclo group, and extension of the benzyl chain at position 5 of the uracil base. BBBAU was a very good potentiator of FUdR in cell culture.
Reactivity of 3H‐pyrimido[5,4‐c] [1,2,5]oxadiazin‐3‐one towards carbanions: Synthesis of pteridine‐2,4‐diones
Authors: Giori P. , Poli T. , Veronese A. C. , Vicentini C. B. , Manfrini M. , Guarneri M. 
Published: March 2009

AbstractThe reaction of 3H‐pyrimido[5,4‐c] [1,2,5]oxadiazin‐3‐one (5) with carbanions prepared in situ from compounds containing an activated methylene group afforded 6,7‐disubstituted pteridine‐2,4‐diones 7a‐m in good yields. The reaction mechanism, involving the initial attack by carbanion at oxadiazinone nitrogen atom bonded to oxygen, is proposed and discussed.
Polycyclic N‐hetero compounds. XXVII. Synthesis and investigation of the antidepressive activity of a B‐Homo‐11,13,15‐triazasteroid and its related compoundsd
Authors: Hirota Takashi , Ieno Katsuhiro , Sasaki Kenji 
Published: March 2009

AbstractA synthesis of 1,2,5,6‐tetrahydro‐4H‐benzo[3,4]cyclohepta[1,2‐e]imidazo[1,2‐c]pyrimidine (XII) having a novel ring system is described. Antidepressive activity of XII and its precursors VII‐X was screened by inhibitory action of reserpine‐induced hypothermia.
Intramolecular sulphonyl‐amidomethylation. Part I. Cyclization of benzylsulphonamides
Authors: Orazi Orfeo O. , Corral Renée A. , Bravo Rodolfo 
Published: March 2009

AbstractCyclization of benzylsulphonamides with aldehydes in strong acid media is a synthetically useful route to 3,4‐dihydro‐1H‐2,3‐benzothiazine 2,2‐dioxides III. With insufficient acid strength or reaction time, kinetic products IV and VI are obtained; the latter compounds can be converted into the thermodynamic products III under stronger conditions. The reactions proceed via imine VII or iminium VIII compounds as common intermediates.
A convenient preparation of 1,4‐dihydro‐1‐methyl‐4‐oxo‐2‐quinolinecarboxaldehyde from N‐methylisatoic anhydride
Authors: Coppola Gary M. 
Published: March 2009

AbstractThe dianion of hydroxyacetone is readily generated with LDA in THF at ‐65°. This dianion reacts rapidly with N‐methylisatoic anhydride (6) at ‐65° to furnish 2‐hydroxymethyl‐1‐methylquinolin‐4(1H)‐one (12). The alcohol is oxidized to aldehyde 4 with manganese dioxide, and is subsequently converted to α,β‐unsaturated ester 5 under Horner‐Emmons conditions.
Synthesis, 13C‐NMR characterization and antimicrobial properties of a novel series of 3‐(N‐Substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino‐[5,6‐b]indole derivatives
Authors: Omar A.‐Mohsen M. E. , Eshba Nabil H. , Aboushleib Hamida M. 
Published: March 2009

AbstractA series of 3‐(N‐substituted thiocarbamoyl)hydrazino‐1,2,4‐triazino[5,6‐b]indole derivatives 3–22 has been synthesized and evaluated for in vitro antimicrobial activity. Although some of the products displayed significant activity against Staphylococcus aureus, Escherichia coli and Candida albicans, their bactericidal and bacterostatic potencies were lower than that of penicillin G. The structure of the products was assigned upon the basis of their infrared, 1H‐nmr and 13C‐nmr spectra.
Synthesis of pyrido[1′,2′:1,2]imidazo[4,5‐b]pyrazines from 2‐amino‐3‐chloro‐5,6‐dicyanopyrazine with substituted pyridines
Authors: Mitsuhashi Keiryo , Nagae Yasushi , Suzuki Toshinobu 
Published: March 2009

AbstractNovel synthesis of the title compounds by the cyclization between 2‐amino‐3‐chloro‐5,6‐dicyanopyrazine and various substituted pyridines is described.
Convenient synthesis of substituted 3‐aminothiophene‐2‐carbonitriles from α‐acetylenic nitriles and their conversion to thieno[3,2‐d]pyrimidines
Authors: Ren Wu‐Yun , Rao Kambhampati V. B. , Klein Robert S. 
Published: March 2009

AbstractSeveral novel 2,4,6‐trisubstituted thieno[3,2‐d]pyrimidines were synthesized from the hitherto unknown 3‐amino‐5‐methyl‐(or 5‐phenyl)thiophene‐2‐carbonitriles 7 and 8. o‐Aminonitriles 7 and 8 were obtained in a single step by conjugate addition of mercaptoacetonitrile (generated in situ) to substituted acetylenic nitriles 4 and 5 and annelation of the intermediate vinylic thioethers.
One‐Pot synthesis of unsymmetrically substituted 2,4‐dialkylisoflavenes
Authors: Alberola Angel , Andrés Celia , Ortega Alfonso González , Pedrosa Rafael , Vicente Martina 
Published: March 2009

AbstractThe trimethylsilyl derivative of formonometine reacts sequentially with two different organometallic derivatives to afford regiospecifically and with good yield 2,4‐dialkylisoflavenes unsymmetrically substituted.
Heterocycles. IX. Synthesis of new substituted benzo[h]quinolones
Authors: El‐Rayyes N. R. , Al‐Saleh B. , Al‐Omran F. , Edun M. 
Published: March 2009

Abstract2‐Arylidine‐1‐tetralones I were condensed with phenyl‐, p‐chlorophenyl‐, and p‐methoxyphenylacetamides A in the presence of a base to yield the corresponding benzo[h]quinolones II‐IV. Dehydrogenation of compounds II gave the benzoquinolones V which upon acetylation yielded the corresponding 2‐acetyl derivatives VI. The structure of all products was substantiated by chemical and spectral methods.
Non conventional syntheses of heterocyclic compounds. 2. Synthesis of 1H‐4,5‐dihydro‐1,3,4‐benzotriazepine derivatives
Authors: Fusco Raffaello , Marchesini Alessandro , Sannicolò Franco 
Published: March 2009

AbstractArylazoanils carrying aromatic methyl or ethyl groups in the position ortho to the imine function thermally cyclize to give 1H‐4,5‐dihydro‐1,3,4‐benzotriazepine derivatives in fairly good yields. A study of the effect of the substituents on both the aryl rings is reported. The reaction is interpreted as an internal oxo‐reduction process.