bluuebunny/crossref_metadata_2025_split huggingface dataset:
A correlative cytologic and histologic study of malignant fibrous histiocytoma: An analysis of 40 cases examined by fine‐needle aspiration cytology
Authors: Walaas Lisa , Angervall Lennart , Hagmar Björn , Säve‐Söderbergh Johan 
Published: February 2007

AbstractA correlative cytologic and histologic study of 40 cases of histologically highly pleomorphic malignant fibrous histiocytoma (MFH) is presented. The fine‐needle aspiration biopsy was performed preoperatively, and a diagnosis of malignant soft‐tissue tumor could be established in all cases. The cytologic and histologic features corresponded well with each other. The two main cell types were mono‐ and multinucleated, large polymorphic, often bizarre, histiocyte‐like cells and atypical fibroblast‐like cells. For a correct diagnosis of pleomorphic MFH, it is important to recognize atypical large polymorphic tumor cells showing signs of phagocytosis: prominent cytoplasmic vacuolization, cell debris or even well‐preserved cells within the tumor cell cytoplasm. Phagocytic activity was easily demonstrated in air‐dried and May‐Grünwald Giemsa‐stained material. The differential diagnosis of MFH as opposed to other soft‐tissue sarcomas and pleomorphic carcinomas is discussed. Diagn Cytopathol 1986;2:46‐54.
Parathyroid cytopathology
Authors: Davey Diane Davis , Giant Michael D. , Berger Eric K. 
Published: February 2007

AbstractCytologic criteria for diagnosing parathyroid adenomas and hyperplasia have not been elucidated. This report will present the cytomorphology of parathyroid tissue in the spectrum of normal, hyperplastic, and neoplastic states. We examined clinical needle aspirates from three patients with parathyroid lesions as well as 15 needle aspirations or touch preparations from surgical specimens. The series included three with hyper‐parathyroidism secondary to chronic renal failure, four with primary chief cell hyperplasia, nine with typical adenomas, and two with atypical adenomas. Normal parathyroid glands were also studied. Most parathyroid lesions could be distinguished from thyroid lesions by frequent thick fragments of cohesive cells with frayed edges and typical nuclear features. In general, the nuclei were small (6‐8 μ) and round with regular coarse granular chromatin. Occasional larger nuclei (10‐30 μ) with similar chromatin were observed in some cases. Oxyphil cells with abundant granular cytoplasm were present in some cases; one case with mostly oxyphil cells was difficult to differentiate from a thyroid neoplasm. Pseudocolloid was found in seven cases. Criteria for the differentiation between parathyroid hyperplasia and adenomas were not discovered. In addition, the cytology and differential diagnosis of atypical parathyroid adenomas are described and illustrated. Diagn Cytopathol 1986;2:76‐80.
Diagnosis of primary hepatic neoplasms by fine‐needle aspiration cytology
Authors: Suen Kenneth C. 
Published: February 2007

AbstractThis article describes the cytologic features of various primary hepatic neoplasms as seen in fine‐needle aspirates. Hepatocellular carcinoma can be differentiated from metastatic carcinoma by its tendency to recapitulate the characteristics of normal hepatocytes, namely, resemblance of the neoplastic cells to liver cells, growth in trabeculae, and bile production. Fibrolamellar hepatocellular carcinoma is characterized by larger, polygonal tumor cells with clearly defined cell outline, deeply eosinophilic granular cytoplasm, and extremely large solitary nucleoli. Lamellae of fibrocytes are seen dividing the tumor cells into small groups. Hepatocellular adenoma and focal nodular hyperplasia exhibit cells that are benign‐appearing or minimally atypical. Cholangiocarcinoma is an adenocarcinoma and cannot be differentiated from metastatic adenocarcinoma on purely morphologic grounds. Primary hepatic sarcoma is exceptionally rare and shows malignant spindle cells. Some inflammatory conditions such as abscess, cysts, and tuberculoma often present as space‐occupying lesions and should be included in the differential diagnosis of hepatic neoplasm. Diagn Cytopathol 1986;2:99‐109.
Malignant thymic neoplasms: Diagnosis by fine‐needle aspiration biopsy with histologic, immunocytochemical, and ultrastructural confirmation
Authors: Finley James L. , Silverman Jan F. , Strausbauch Paul H. , Dabbs David J. , West Robert L. , Weaver Michael D. , Norris H. Thomas 
Published: February 2007

AbstractTwo cases of malignant thymic neoplasms diagnosed by trans‐thoracic fine‐needle aspiration (FNA) biopsy under fluoroscopic and computerized axial tomography (CT) guidance with histologic, immunocytochemical, and ultrastructural confirmation are presented. The clinical and cytomorphologic features of the first case were typical of a malignant thymoma. A characteristic biphasic cell population of benign epithelial cells and mature lymphocytes was seen in Diff‐Quik‐ and Papanicolaou‐stained smears from the anterior mediastinal mass and the paravertebral metastasis and was confirmed by histologic examination. Immunoperoxidase studies for T and B cell subsets demonstrated lymphocytes with the thymic lymphocyte phenotype (Leu 6). Electron microscopic (EM) examination revealed epithelial cells with desmosomal attachments, tonofilaments, and extended cell processes along with mature lymphocytes. FNA biopsy of the second case demonstrated features of a thymic carcinoma. Individually scattered and loosely clustered small groups of markedly anaplastic and pleomorphic large cells were seen both in the Diff‐Quik‐ and Papanicolaou‐stained smears. EM performed on the FNA specimen demonstrated the poorly differentiated epithelial nature of the malignancy. The mediastinal mass was partially resected and demonstrated an undifferentiated carcinoma staining positively for low‐molecular‐weight cytokeratin. Ultrastructure demonstrated cell attachments and relationships consistent with carcinoma. The tack of a lung or other extrapulmonary primary tumor was consistent with a thymic carcinoma. These cases demonstrate the value of performing EM and immunocytochemistry on material obtained by fine‐needle aspiration, which can aid in establishing the correct diagnosis and facilitate the clinical management of patients with malignant thymic neoplasms. Diagn Cytopathol 1986;2:118‐125.
Exfoliative cytology of clear‐cell sarcoma metastases in pleural fluid
Authors: Nguyen Gia‐Khanh , Shnitka Theodor K. , Jewell Laurence D. , Wroblewski Julius A. 
Published: February 2007

AbstractTwo cases of clear‐cell sarcoma arising from the leg with widespread metastasis were reported. Exfoliated tumor cells in pleural effusions were round, oval, and slightly pleomorphic. They were seen singly or in clusters of variable size with marked cellular cohesiveness and molding. Their cytoplasm was well‐defined, clear, or finely granular, and contained S‐100 protein and periodic acid‐Schiff positive material that was digestible by diastase. Tumor‐cell nuclei were round and hyperchromatic with irregular chromatin clumping, and showed conspicuous nucleoli. Diagn Cytopathol 1986;2:144‐149.
Malignant melanoma in effusions: A source of false‐negative cytodiagnoses
Authors: Walts Ann E. 
Published: February 2007

AbstractMelanoma, a not uncommon tumor, is associated with variable cytomorphology and unpredictable metastatic potential. Although most cytologic diagnoses of malignant melanoma represent metastatic disease, the diagnosis is frequently unsuspected clinically. Three effusions in which cells from metastatic melanomas were not diagnosed are described. Clinical factors that may have contributed to the erroneous cytodiagnoses are illustrated. Cytologic features and adjunctive studies that are helpful in identifying melanoma cells are discussed. Diagn Cytopathol 1986;2:150‐153.
Semiquantitative approach to csf cytopathology
Authors: Schumann G. Berry , Crisman Linda G. 
Published: February 2007

AbstractDuring the past two years, our laboratory has introduced a semiquantitative membrane filter approach to cerebrospinal fluid (CSF) cytology. Five hundred and thirty‐five CSF specimens, averaging 3 ml in volume, were placed over 25‐mm diameter Milliporer̀ filters (5‐μ pore size) and stained using a modified Papankolaou method. Each microscopic evaluation consisted of a cell count per milliliter, a 100‐cell differential, and a diagnostic or interpretive statement. Seventy‐four (13.8%) positive, 17 (3.2%) atypical, 439 (82%) negative, and 4(1%) unsatisfactory specimens were evaluated. Seventy‐four percent of the positive or atypical CSF specimens had mononuclear cell counts within the medically accepted normal range of five mononuclear cells per cubic millimeter (chamber count method) or 5,000 cells per milliter (cytologic method). The small‐filter technique offered advantages because it maximized cell retrieval, localized cells, and shortened the time required for microscopic evaluation. Diagn Cytopathol 1986;2:194‐197.
The cytology of the normal cyclic endometrium
Authors: Coscia‐Porrazzi Luigi O. , Maiello Francesco M. , de Falco Maria L. 
Published: February 2007

AbstractEndometrial cytologic samples obtained with Cohen's endocyte from 501 normally menstruating women were studied and correlated with histologic sections from cell blocks. In this article, the cytologic diagnostic criteria for normal cyclic endometrium are pointed out. The diagnostic accuracy of normal cyclic endometrium has been 92%. A possibility of a cytologic dating is discussed. The diagnostic accuracy was 71.8% for early proliferative endometria, 82% for late proliferative, 93% for early secretory, 81% for midsecretory, and 60% for late secretory endometria. Diagn Cytopathol 1986;2:198‐203.
Hyperplastic and neoplastic endocrine cells of the pancreas in aspiration biopsy
Authors: Nguyen Gia‐Khanh , Rayani Nargis A. 
Published: February 2007

AbstractAspiration biopsy of four primary endocrine tumors of the pancreas showed single and large sheets of tumor cells. Tumor cells were polygonal in shape with ill‐defined, filmy or granular cytoplasm and regular round nuclei containing a finely granular chromatin pattern and inconspicuous or prominent nucleoli. Focal gland‐like arrangement was seen in several sheets of tumor cells. Aspirate from liver metastases of an endocrine tumor of the pancreas showed single and clustered oval cells with granular cytoplasm and eccentrically located round and hyperchromatic nuclei. Smears prepared from aspirates of three fibrotic pancreata containing nodules of hyperplastic endocrine cells showed smaller fragments of endocrine‐cell epithelium with focal gland‐like arrangement. Individual hyperplastic endocrine cells displayed granular, filmy, and ill‐defined cytoplasm and round to oval hyperchromatic nuclei showing a finely granular chromatin pattern. Nuclear pleomorphism was noted in some cell groups. Diagn Cytopathol 1986;2:204–211.
Immunodetection of neuron‐specific enolase and keratin in cytological preparations as an aid in the differential diagnosis of lung cancer
Authors: Kyrkou Kalliopi A. , Latridis Sotirios G. , Athanassiadou Pauline P. , Lambropoulou Sofia , Liossi Anna 
Published: February 2007

AbstractThe results of neuron‐specific enolase (NSE) and keratin immunodetection in cytological specimens of sputum secured from 41 patients with lung cancer are presented. All 19 cases of small‐cell carcinoma showed intense immunoreactivity for NSE. No such immunoreactivity was found in 21 of 22 cases of non‐small‐cell carcinoma. The single positive result was from a case of large‐cell undifferentiated carcinoma. All 10 cases of squamous‐cell carcinoma showed immunoreactivity for keratin. The 19 cases of small‐cell carcinoma showed no such reactivity. Our findings indicate that immunostaining for NSE and keratin is a valuable aid when a definite diagnosis of small‐cell carcinoma of the lung can not be made on the basis of conventional cytologic features. Diagn Cytopathol 1986;2:217‐220.
Percutaneous fine‐needle aspiration biopsy of the pancreas
Authors: Bret Patrice M. , Nicolet Viviane , Labadie Michel 
Published: February 2007

AbstractPercutaneous fine needle aspiration biopsy of the pancreas allows to obtain without surgery a tissue proven diagnosis of focal lesions of the pancreas. Ultrasound (US), computed tomography (CT), or fluoroscopy are used to guide the positioning of the needle in the lesion. Various benign and malignant lesions can be diagnosed and the cytologic features of them are presented. The average sensitivity of the technique in the diagnosis of pancreatic carcinoma is 80.5% in the literature. The use of percutaneous fine needle biopsy of the pancreas decreases the number of investigations to be done in a patient with pancreatic disease. Diagn Cytopathol 1986;2:221‐227.
Primary cytodiagnosis of peritoneal extramedullary hematopoiesis
Authors: Stephenson Robert W. , Britt Dawn A. , Schumann G. Berry 
Published: February 2007

AbstractCytologic examination of peritoneal fluid in a patient with known myelofibrosis and previous splenectomy revealed mega‐karyocytes along with erythroid and myeloid precursors. These findings were consistent with extramedullary hematopoietic (EMH) implants of the peritoneum. A few similar cases have been occasionally reported in the literature. This case represents an additional example of a primary diagnosis of peritoneal EMH in which therapy was based on the cytologic findings and sequential cytologic observations were made. Diagn Cytopathol 1986;2:241 243.
Ancient neurilemoma: A pitfall in the cytologic diagnosis of soft‐tissue tumors
Authors: Ryd Walter , Mugal Sanjida , Ayyash Khalid 
Published: February 2007

AbstractA case of ancient neurilemoma (Schwannoma) is presented that, owing to a severe cell pleomorphism, was falsely interpreted as a malignant spindle‐cell sarcoma by fine‐needle aspiration cytology. Cytological features of the tumor are given together with its histopathology and electron microscopy findings. The usefulness of electron microscopy on material obtained by fine‐needle aspiration biopsies in the diagnosis of soft‐tissue tumors is discussed. Diagn Cytopathol 1986;2:244‐247.
Fine‐needle aspiration of metastatic sacrococcygeal myxopapillary ependymoma
Authors: Wahl Robert W. 
Published: February 2007

AbstractA 45‐yr‐old white woman with a 24‐yr history of sacrococcygeal myxopapillary ependymoma developed a large metastasis of scalp and skull diagnosed as metastatic ependymoma on fine‐needle aspiration, based on cytologic features, histotogic pattern in cell block fragments, and a positive reaction with the glial fibrillary acidic protein immunoperoxidase study. The fine‐needle study obviated the need for biopsy in this case, for which a surgical approach was considered to be inappropriate due to the extent of the process demonstrated by various imaging techniques. Diagn Cytopathol 1986;2:261–263.
Transthoracic needle biopsy in neoplastic and nonneoplastic pathology: Experience in a general hospital
Authors: Alonso Patricia , Sánchez Susana , Ramírez Ernestina , Cicero Raúl 
Published: February 2007

AbstractTransthoracic needle biopsy (TNB) was performed in 344 cases of intrathoracic pathology. In 60 of them, the material obtained was inadequate. In the remaining 284, the possibilities of TNB to identify malignant cells were evaluated. Of them, 202 had neoplastic lesions and 82 had nonneoplastic processes. Among the neoplastic cases, malignant cells were found in 188, (true positive), and in 14 the results were false negative. In the group of nonneoplastic processes, there were 80 without malignant cells (true negative), and two were diagnosed as malignant, (false positive). In these 284 cases with cytologic diagnosis, the global sensitivity was 0.93, and the specificity was 0.97; however, including all cases and the inadequate samples as false negatives, the sensitivity is lower—0.71. TNB required some skill, the use of fine needles, and the colaboration of an expert cytopathologist. TNB is an important method with which to explore intrathoracic pathology. Diag Cytopathol 1986;2:284‐289.
Cytology of hepatocellular carcinoma
Authors: Gupta Subhash K. , Das Dilip K. , Rajwanshi A. , Bhusnurmath S. R. 
Published: February 2007

AbstractTwenty‐five cases of cytologically and histologically confirmed hepatocellular carcinoma (HCC) were cytomorphologically analyzed using May‐Grünwald‐Giemsa (MGG)‐stained aspiration smears and supplemented with special stains. The cell types were categorized as well differentiated (18 cases), vacuolated (four cases), giant cell (one case), and poorly differentiated (two cases). Glycogen staining was positive in 80% of the cases and hence served as a reliable parameter of diagnostic importance in HCC. Cytoplasmic hyaline bodies (14.6%) and bile pigment (17%), when present, were other important features supporting the diagnosis of HCC. Vacuolation of the cell cytoplasm (80%) was possibly related to glycogen accumulation. The cause of nuclear vacuolation (60%) and the significance of nuclear argyrophilia as markers of abnormal cell growth remain to be studied. Diagn Cytopathol 1986;2:290‐294.
Immunocytochemical localization of human papilloma virus and cytomorphologic correlation in smears and biopsies of cervical flat condylomata
Authors: Deligeorgi‐Politi H. , Mui K. K. , Trotta K. , Safaii H. , An‐Foraker S. H. , Wolfe H. , Hutchinson M. 
Published: February 2007

AbstractThe cytomorphologic features in cervical biopsies and smears associated with human papilloma virus antigen (Ag) expression as demonstrated by immunoperoxidase staining techniques are presented. There was good concordance between cytology and biopsy results with respect to immunoperoxidase staining for human papilloma virus Ag. Cytomorphologic scoring of low‐grade lesions (cervical intraepithelial neoplasias, grades 0 and I) showed atypical mitoses, macronucleated koilocytes, superficial cell keratohyaline granules, and multinucleation to be more frequent in Ag+ biopsy specimens. Chronic inflammation was more evident in Ag‐ biopsy specimens (P < 0.05). Parakeratosis was more frequent in Ag+ cytologic specimens. Koilocytosis was not a reliable indicator of Ag expression in either preparation. Human papilloma virus (HPV) Ag testing by immunoperoxidase techniques appears to be a useful adjunct for screening low‐grade atypias of the cervix. Diagn Cytopathol 1986;2:320‐325.
Cytomegalovirus infection of the lung: Cytomorphologic diagnosis by fine‐needle aspiration cytology
Authors: Buchanan Andrew J. , Gupta Raj K. 
Published: February 2007

AbstractCytomegalovirus (CMV) infection of the lung was diagnosed by fine‐needle aspiration cytology (FNAC) in a patient who underwent renal transplantation due to end‐stage renal failure. This case illustrates that CMV can be diagnosed by FNAC and, when seen, must be reported in an immunocompromised host. Diagn Cytopathol 1986;2:341‐342.
The role of routine outpatient cytological screening for early detection of carcinoma of the cervix in India
Authors: Engineer Amy D. , Misra Jata S. 
Published: February 2007

AbstractCytological evaluation of cervical smears has been carried out in 4,338 women attending the Gynecology and Obstetrics Department and Family Planning Clinic of Queen Mary's Hospital, Lucknow, India, since April 1971. The incidence of cervical dysplasia was found to be 4.6% (205 out of 4,338) in the series, while malignant smears were detected in 54 patients (1.2%). In five cases, malignant smears were encountered in women with apparently normal cervices, highlighting the advantage of exfoliative cytology in screening subjects without cervical pathology. The remaining 49 cases with malignant smears had lesions on the cervix that had been clinically diagnosed as carcinoma. The diagnosis of malignancy was confirmed by biopsy in all 54 cases showing malignant smears; however, in 10 cases clinically diagnosed as carcinoma of the cervix, and subsequently confirmed histologically, the diagnosis was missed by cytology, the smears being reported as inflammatory in seven and inadequate in three. Cytological evidence of herpes simplex infection was seen in the smears in 23 out of 54 cases of carcinoma, and trichomonal infection was present in 15, indicating some relationship of these infections with the development of neoplastic changes in the cervical epithelium. Eleven of the total 54 cases of carcinoma of the cervix were in the age group of 26‐35 yr, and four were in subjects with only two children. This emphasizes the need for the routine cytologic screening of all child‐bearing women with parities of two and above, regardless of their age, if any meaningful results are to be obtained in a cancer‐screening program in India in view of the prevailing custom of early marriage. Diagn Cytopathol 1987;3:30–34.
Fine‐needle aspiration cytology in pancreatic endocrine tumors
Authors: Sneige Nour , Ordonez Nelson G. , Veanattukalathil Susan , Samaan Naguib A. 
Published: February 2007

AbstractPancreatic endocrine tumors (PETs) are relatively uncommon neoplasms. Although their histologic patterns have been widely studied, their cytologic features as they appear in fine‐needle aspiration (FNA) specimens have rarely been reported. In this study, aspirates of seven PETs, four primary and three metastatic lesions (two to liver and one to bone), are described. The tumors occurred in seven men ranging in age from 37 to 72 yr. Six tumors presented as nonfunctioning masses and one produced Zollinger‐Ellison syndrome. Three were located in the head of the pancreas and four in the body and tail. The pancreatic and liver aspirations were performed under computed tomographic guidance and the bone lesion, under fluoroscopy. The aspiration specimens were hypercellular. The tumor cells occurred singly and in small clusters. In three cases, there was a tendency toward acinar formations. In two cases, there were prominent, thin‐walled, branching blood vessels with tumor cells attached to the vascular walls. The cells were round or polygonal with a moderate amount of finely granular, well‐defined cytoplasm. The nuclei were eccentrically located and round‐to‐oval—with one or two small nucleoli and finely granular, evenly‐dispersed chromatin. The diagnosis was confirmed by immunocytochemistry (two cases) and electron microscopy (four cases) of the aspirated material and histology sections of the resected tumors (two cases). The results of this study demonstrate that FNA is a useful method to establish the diagnosis of PETs. Diagn Cytopathol 1987;3:35–40.
Epithelial membrane antigen in the cytodiagnosis of effusions and aspirates: Immunocytochemical and ultrastructural localization in benign and malignant cells
Authors: Walts Ann E. , Said Jonathan W. , Shintaku I. Peter 
Published: February 2007

AbstractImmunoreactivity for epithelial membrane antigen (EMA) was evaluated in exfoliated benign and malignant cells using immunoperoxidase and immunogold techniques. In addition, protein A‐colloidal gold was used for ultrastructural localization of EMA. Our results suggest that EMA is useful in distinguishing adenocarcinoma cells (strongly positive) from reactive mesothelial cells (negative or weakly positive), lymphoid cells (negative), and a variety of nonepithelial neoplasms (negative) with which they may be confused. Exfoliated cells from two mesotheliomas were also strongly positive for EMA. Ultrastructurally, EMA was distributed in a dense, even, linear pattern along the cell membrane and microvillous surface processes of adenocarcinoma cells. A similar but sparse distribution pattern was observed in reactive mesothelial cells. These observations reflect the increased sensitivity and higher resolution of the immunogold technique. Diagn Cytopathol 1987;3:41–49.