bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological and Biochemical characters of <i>Nigrospora gorlenkoana</i> Novobr. Occurring on Cereals
Authors: Orina A. S. , Gavrilova O. P. , Gagkaeva T. Yu. 
Published: April 2024

The ubiquitous distribution of Nigrospora fungi in the mycobiota of cereal grain in Russia has been established. Fourteen Nigrospora strains using phylogenetic analysis of ITS, tub, and TEF loci were identified as N. gorlenkoana, first identified in Russia. Morphological characteristics of N. gorlenkoana strains were analyzed on various nutrient media. A wide temperature range of 15–25°C was optimal for growth of N. gorlenkoana strains. This probably contributes to the wide distribution of N. gorlenkoana in nature. The pathogenicity of N. gorlenkoana strains to cereal crops was shown. The fungal strains reduced length of wheat and barley seedlings on average 48% and 39% compared to the control, respectively.
Aircraft Collisions With Birds (Order <i>Falconiformes</i> and <i>Accipitriformes</i>)
Authors: Silaeva O. L. , Pedenko A. S. 
Published: April 2024

Statistical data on aircraft collisions with birds of prey (Falconiformes and Accipitriformes) are analysed. The basis of the analysis was the results of the IPEE RAS study. The reasons and factors attracting birds of prey to airfields are considered. In the period from 2005 to 2022 seven species of birds of prey involved in 29 collisions with aircraft were identified. The largest number of birdstrike occur with common kestrel Falco tinnunculus and common buzzard Buteo buteo. The most collisions occur on the airport or in its vicinity; there is a 4.3 times more strikes by taking off than by landing. From raptor birds’ collisions suffer mainly engine and wing structure. Recommendations are given to control birds’ behaviour for minimizing strikes with birds of prey at the airfield.
Iron Accumulation of Halophytes on the White Sea Littoral Zone
Authors: Terebova E. N. , Pavlova M. A. , Oreshnikova N. V. 
Published: April 2024

The accumulation of iron in halophytic species Triglochin maritima L., Plantago maritima L., Aster tripolium L. and Zostera marina L. was studied in this research. Littoral soils are not contaminated with iron (6–16 g/kg). Seawater, on contrary, contains high concentrations of iron (0.04–0.32 mg/l). Halophytes accumulate iron to supervalues (6.49–71.63 г/кг), 93% of metal is found in rhyzomes. The reasons for this phenomenon are discussed. Halophytes of the White Sea littoral zone are involved in the biogeochemical iron cycle as the main fixation sites of iron in the system “coast–sea”. They have phytoremediation potential on the coastal territories.
PENGARUH UKURAN PERUSAHAAN, PROFITABILITAS DAN LIKUIDITAS TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY (CSR) PADA PERUSAHAAN MAKANAN DAN MINUMAN
Authors: Apriyeni Deltri , Putra Ridho Juanda , Sari Fitria 
Published: April 2024

ABSTRAK: Penelitian ini bertujuan untuk mengetahui pengaruh 1) ukuran perusahaan, profitabilitas, likuiditas terhadap pengungkapan tanggung jawab sosial perusahaan (CSR) pada perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia periode 2019-2021. Perusahaan harus memiliki tanggung jawab terhadap lingkungan dan sosial terhadap masyarakat dilingkungan perusahaan didirikan. Desain penelitian adalah penelitian kuantitatif. Data yang digunakan adalah data sekunder yaitu ; 26 perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia periode 2019-2021. Metode pengambilan sampel menggunakan metode purposive sampling. Teknik pengolahan data menggunakan regresi data panel diolah dengan Eviews versi 8.0. Hasil penelitian menunjukkan bahwa ; ukuran perusahaan, profitabilitas, tidak berpengaruh terhadap pengungkapan CSR pada perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia tahun 2019-2021, dan likuiditas berpengaruh positif dan signifikan terhadap Pengungkapan CSR pada perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia tahun 2019-2021. Kata Kunci: Bursa Efek Indonesia, profitabilitas, likuiditas
DETERMINAN PENANAMAN MODALASING DI INDONESIA TAHUN 2012-2022
Authors: Syahrindra Diony Kevin , Purnomo Didit 
Published: April 2024

Modal adalah komponen penting yang berfungsi sebagai pendorong pertumbuhan ekonomi dan pembangunan. Salah satu jenis modal yang paling cocok untuk pembiayaan adalah penanaman modal asing guna mendorong pertumbuhan ekonomi. Oleh karena itu, tujuan dari penelitian ini yaitu untuk mengidentifikasi faktor-faktor yang mempengaruhi penanaman modal asing. Penelitian ini menggunakan analisis regresi model lengkap dan wilayah yang menjadi sampel pada penelitian ini adalah negara Indonesia. Data yang digunakan adalah dengan kurun waktu sebelas tahun (2012-2022). Hasil penelitian menunjukkan bahwa angka harapan hidup laki-laki, angka harapan hidup perempuan, dan tingkat partisipasi angkatan kerja tidak berpengaruh pada penanaman modal asing, sedangkan produk domestik bruto dan indeks pembangunan manusia berpengaruh terhadap penanaman modal asing.
Isolation of quinic acid from dropped Citrus reticulata Blanco fruits: its derivatization, antibacterial potential, docking studies, and ADMET profiling
Authors: Heena  , Kaushal Sonia , Kaur Vishaldeep , Panwar Harsh , Sharma Purshotam , Jangra Raman 
Published: April 2024

Citrus reticulata dropped fruits are generally discarded as waste, causing environmental pollution and losses to farmers. In the present study, column chromatography has been used to isolate quinic acid (1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid) from the ethyl acetate fraction of a methanol extract of citrus fruits dropped in April. Quinic acid is a ubiquitous plant metabolite found in various plants and microorganisms. It is an important precursor in the biosynthesis of aromatic natural compounds. It was further derivatized into 3,4-o-isopropylidenequinic acid 1,5-lactone (QA1), 1,3,4,5-tetraacetoxycyclohexylaceticanhydride (QA2), and cyclohexane-1,2,3,5-tetraone (QA3). These compounds were further tested for their antibacterial potential against the foodborne pathogens Staphylococcus aureus, Bacillus spp., Yersinia enterocolitica, and Escherichia coli. QA1 exhibited maximum antibacterial potential (minimum inhibitory concentration; 80–120 μg/mL). QA1 revealed synergistic behavior with streptomycin against all the tested bacterial strains having a fractional inhibitory concentration index ranging from 0.29 to 0.37. It also caused a significant increase in cell constituent release in all the tested bacteria compared to the control, along with prominent biofilm reduction. The results obtained were further checked with computational studies that revealed the best docking score of QA1 (−6.30 kcal/mol, −5.8 kcal/mol, and −4.70 kcal/mol) against β-lactamase, DNA gyrase, and transpeptidase, respectively. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis revealed that the drug-like properties of QA1 had an ideal toxicity profile, making it a suitable candidate for the development of antimicrobial drugs.
The prediction of two-dimensional PbN: opened bandgap in heterostructure with CdO
Authors: Cheng Zhang , Wang Yuelei , Zheng Ruxin , Mu Weihua 
Published: April 2024

The development of two-dimensional (2D) materials has received wide attention as a generation of optoelectronics, thermoelectric, and other applications. In this study, a novel 2D material, PbN, is proposed as an elemental method using the prototype of a recent reported nitride (J. Phys. Chem. C 2023, 127, 43, 21,006–21014). Based on first-principle calculations, the PbN monolayer is investigated as stable at 900 K, and the isotropic mechanical behavior is addressed by the Young’s modulus and Poisson’s ratio at 67.4 N m–1 and 0.15, respectively. The PbN monolayer also presents excellent catalytic performance with Gibbs free energy of 0.41 eV. Zero bandgap is found for the PbN monolayer, and it can be opened at about 0.128 eV by forming a heterostructure with CdO. Furthermore, the PbN/CdO is constructed by Van der Waals interaction, while the apparent potential drop and charge transfer are investigated at the interface. The PbN/CdO heterostructure also possesses excellent light absorption properties. The results provide theoretical guidance for the design of layered functional materials.
Synchronization of two electrochemical oscillators in a closed bipolar cell
Authors: Tetteh John A. , Kiss István Z. 
Published: April 2024

We investigate the dynamical behavior of the oscillatory electrodissolution of nickel and hydrogen reduction reaction in a closed electrochemical bipolar cell with two nickel wires. In the bipolar setup, two-half U cells are separated by an epoxy plate with the two embedded nickel electrodes; the oxidation and reduction reactions take place at the two ends of the same wire. The electrode potential oscillations were found to be strongly synchronized with 1 mm diameter electrodes in an in-phase configuration. Because experiments in similar configurations with traditional (three-electrode) cell showed no synchronization of the oscillatory anodic nickel electrodissolution, the introduction of the cathodic side of the bipolar electrodes induced the synchronization. The results were interpreted with a model that considered the kinetically coupled cathode-anode dynamics as well as interactions on the cathode and the anode side through migration current mediated potential drops in the electrolyte. The electrical coupling strength was calculated from solution resistance and charge transfer resistance measurements. The theory correctly interpreted that the bipolar cell with large (1 mm diameter) electrodes exhibits strong coupling with synchronization, and the bipolar cell with small (0.25 mm diameter) electrodes and the traditional configuration exhibit weak coupling and thus desynchronization. The experiments demonstrate the use of bipolar electrochemical cells for the investigation of collective behavior of electrochemical processes and the proposed approach holds promise for the design of bipolar multi-electrode arrays with engineered coupling to promote sensing and information processing using microchips.
Dose–response association between Chinese visceral adiposity index and cardiovascular disease: a national prospective cohort study
Authors: Ren Yongcheng , Hu Qing , Li Zheng , Zhang Xiaofang , Yang Lei , Kong Lingzhen 
Published: April 2024

BackgroundChinese visceral adiposity index (CVAI) is a reliable visceral obesity index, but the association between CVAI and risk of cardiovascular disease (CVD) remains unclear. We explored the associations of CVAI with incident CVD, heart disease, and stroke and compared the predictive power of CVAI with other obesity indices based on a national cohort study.MethodsThe present study included 7,439 participants aged ≥45 years from China Health and Retirement Longitudinal Study (CHARLS). Cox regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic splines analyses were adopted to model the dose–response associations. Receiver operator characteristic (ROC) analyses were used to compare the predictive ability of different obesity indices (CVAI, visceral adiposity index [VAI], a body shape index [ABSI], conicity index [CI], waist circumference [WC], and body mass index [BMI]).ResultsDuring 7 years’ follow‐up, 1,326 incident CVD, 1,032 incident heart disease, and 399 stroke cases were identified. The HRs (95% CI) of CVD, heart disease, and stroke were 1.50 (1.25-1.79), 1.29 (1.05-1.57), and 2.45 (1.74-3.45) for quartile 4 versus quartile 1 in CVAI. Linear associations of CVAI with CVD, heart disease, and stroke were observed (Pnonlinear &gt;0.05) and per-standard deviation (SD) increase was associated with 17% (HR 1.17, 1.10-1.24), 12% (1.12, 1.04-1.20), and 31% (1.31, 1.18-1.46) increased risk, respectively. Per-SD increase in CVAI conferred higher risk in participants aged&lt;60 years than those aged ≥60 years (Pinteraction&lt;0.05). ROC analyses showed that CVAI had higher predictive value than other obesity indices (P&lt;0.05).ConclusionsCVAI was linearly associated with risk of CVD, heart disease, and stroke and had best performance for predicting incident CVD. Our findings indicate CVAI as a reliable and applicable obesity index to identify higher risk of CVD.
Alzheimer’s disease as a causal risk factor for diabetic retinopathy: a Mendelian randomization study
Authors: Ouyang Fu , Yuan Ping , Ju Yaxin , Chen Wei , Peng Zijun , Xu Hongbei 
Published: April 2024

ObjectivesThis study aims to investigate the causal relationship between Alzheimer’s Disease (AD) and Diabetic Retinopathy (DR).MethodsEmploying Mendelian Randomization (MR), Generalized Summary-data-based Mendelian Randomization (GSMR), and the MR-Steiger test, this study scrutinizes the genetic underpinnings of the hypothesized causal association between AD and DR, as well as its Proliferative DR (PDR) and Non-Proliferative DR (NPDR) subtypes. Comprehensive data from Genome-Wide Association Studies (GWAS) were analyzed, specifically AD data from the Psychiatric Genomics Consortium (71,880 cases/383,378 controls), and DR, PDR, and NPDR data from both the FinnGen consortium (FinnGen release R8, DR: 5,988 cases/314,042 controls; PDR: 8,383 cases/329,756 controls; NPDR: 3,446 cases/314,042 controls) and the IEU OpenGWAS (DR: 14,584 cases/176,010 controls; PDR: 8,681 cases/204,208 controls; NPDR: 2,026 cases/204,208 controls). The study also incorporated Functional Mapping and Annotation (FUMA) for an in-depth analysis of the GWAS results.ResultsThe MR analyses revealed that genetic susceptibility to AD significantly increases the risk of DR, as evidenced by GWAS data from the FinnGen consortium (OR: 2.5090; 95% confidence interval (CI):1.2102-5.2018, false discovery rate P-value (PFDR)=0.0201; GSMR: bxy=0.8936, bxy_se=0.3759, P=0.0174), NPDR (OR: 2.7455; 95% CI: 1.3178-5.7197, PFDR=0.0166; GSMR: bxy=0.9682, bxy_se=0.3802, P=0.0126), and PDR (OR: 2.3098; 95% CI: 1.2411-4.2986, PFDR=0.0164; GSMR: bxy=0.7962, bxy_se=0.3205, P=0.0129) using DR GWAS from FinnGen consortium. These results were corroborated by DR GWAS datasets from IEU OpenGWAS. The MR-Steiger test confirmed a significant association of all identified instrumental variables (IVs) with AD. While a potential causal effect of DR and its subtypes on AD was identified, the robustness of these results was constrained by a low power value. FUMA analysis identified OARD1, NFYA, TREM1 as shared risk genes between DR and AD, suggesting a potential genetic overlap between these complex diseases.DiscussionThis study underscores the contribution of AD to an increased risk of DR, as well as NPDR and PDR subtypes, underscoring the necessity of a holistic approach in the management of patients affected by these conditions.
Effects of temporal changes in resting heart rate on future diabetes-related outcomes
Authors: Gao Lu , Wang Guo-Hong , Wan Gang , Liu Qian , Qin Ming-zhao , Fang Fang , Cui Xue-li , Li Yu-ling , Sun Fei , Zhang Xue-lian , Fu Han-jing , Yuan Shen-yuan 
Published: April 2024

Background and aimsMost studies have analyzed the relationship between resting heart rate (RHR) measured at only one time point and future clinical events. The current study aims to investigate the impact of long-term RHR changes on future clinical outcomes in a decade-long cohort with type 2 diabetes mellitus (T2DM).MethodsThe two-staged follow-up involved 2,513 T2DM participants. The first stage (2008-2014) intended to identify levels and trends in RHR changes, while the second stage (2014-2018) attempted to collect new occurrence records of clinical results. Cox proportional hazards models were applied to predict hazard ratios (HRs), along with 95% confidence interval (CI) for the correlation between RHR changes and future events.ResultsThere is no significant correlation between baseline RHR levels and long-term clinical events. According to the range of RHR change, compared with the stable RHR group, the adjusted HRs for cardiovascular events and all-cause death in the large increase group were 3.40 (95% CI: 1.33-8.71, p=0.010) and 3.22 (95% CI: 1.07-9.64, p=0.037), respectively. While the adjusted HRs for all-cause death and major adverse cardiac and cerebrovascular events (MACCE) in the moderate decrease group were 0.55 (95% CI: 0.31-0.96, p=0.037) and 0.51 (95% CI: 0.26-0.98, p=0.046). According to the trend of RHR, compared with the normal-normal group, the adjusted HRs for composite endpoint events and cerebrovascular events in the normal-high group were 1.64 (95% CI: 1.00-2.68, p=0.047) and 2.82 (95% CI: 1.03-7.76, p=0.043), respectively.ConclusionChanges in RHR had predictive value for long-term clinical events in diabetic populations. Individuals with significantly elevated RHR over a particular period of time showed an increased risk of adverse events.
Carbon neutrality in Malaysia and Kuala Lumpur: insights from stakeholder-driven integrated assessment modeling
Authors: Weber Maridee , Pressburger Leeya , Chau Loon Wai , Khan Zarrar , Waite Taryn , Westphal Michael I. , Ling Gabriel Hoh Teck , Ho Chin Siong , Evans Meredydd 
Published: April 2024

Introduction: Several cities in Malaysia have established plans to reduce their CO2 emissions, in addition to Malaysia submitting a Nationally Determined Contribution to reduce its carbon intensity (against GDP) by 45% in 2030 compared to 2005. Meeting these emissions reduction goals will require a joint effort between governments, industries, and corporations at different scales and across sectors.Methods: In collaboration with national and sub-national stakeholders, we developed and used a global integrated assessment model to explore emissions mitigation pathways in Malaysia and Kuala Lumpur. Guided by current climate action plans, we created a suite of scenarios to reflect uncertainties in policy ambition, level of adoption, and implementation for reaching carbon neutrality. Through iterative engagement with all parties, we refined the scenarios and focus of the analysis to best meet the stakeholders’ needs.Results: We found that Malaysia can reduce its carbon intensity and reach carbon neutrality by 2050, and that action in Kuala Lumpur can play a significant role. Decarbonization of the power sector paired with extensive electrification, energy efficiency improvements in buildings, transportation, and industry, and the use of advanced technologies such as hydrogen and carbon capture and storage will be major drivers to mitigate emissions, with carbon dioxide removal strategies being key to eliminate residual emissions.Discussion: Our results suggest a hopeful future for Malaysia’s ability to meet its climate goals, recognizing that there may be technological, social, and financial challenges along the way. This study highlights the participatory process in which stakeholders contributed to the development of the model and guided the analysis, as well as insights into Malaysia’s decarbonization potential and the role of multilevel governance.
Circulating VEGF and inflammatory bowel disease: a bidirectional mendelian randomization
Authors: Lin Haishan , Cao Bangwei 
Published: April 2024

Introduction: Prior observational studies have suggested an association between circulating vascular endothelial growth factor (VEGF) levels and inflammatory bowel disease (IBD). This study sought to demonstrate the directionality of the association between circulating VEGF and particular forms of IBD as well as if there is a causal relationship between them.Methods: We collected summary data from relevant genome-wide association studies (GWASs) to assess the validity of causality, and a two-sample bidirectional Mendelian randomization (MR) study and sensitivity testing were performed to assess the causal relationship between circulating VEGF and IBD risk, including Crohn’s disease and ulcerative colitis.Results: Our findings revealed a direct causal link between circulating VEGF and Crohn’s disease (b 0.195, se 0.078, p &lt; 0.013). However, neither circulating VEGF nor ulcerative colitis were shown to be causally linked (p &gt; 0.025), nor was there proof of a reverse causal relationship from IBD to VEGF.Discussion: In conclusion, circulating VEGF shows a cause-and-effect relationship with Crohn’s disease.
Exploring inflammatory bowel disease therapy targets through druggability genes: a Mendelian randomization study
Authors: Zhu Shuangjing , Lin Yunzhi , Ding Zhen 
Published: April 2024

BackgroundInflammatory bowel disease is an incurable group of recurrent inflammatory diseases of the intestine. Mendelian randomization has been utilized in the development of drugs for disease treatment, including the therapeutic targets for IBD that are identified through drug-targeted MR.MethodsTwo-sample MR was employed to explore the cause-and-effect relationship between multiple genes and IBD and its subtypes ulcerative colitis and Crohn’s disease, and replication MR was utilized to validate this causality. Summary data-based Mendelian randomization analysis was performed to enhance the robustness of the outcomes, while Bayesian co-localization provided strong evidential support. Finally, the value of potential therapeutic target applications was determined by using the estimation of druggability.ResultWith our investigation, we identified target genes associated with the risk of IBD and its subtypes UC and CD. These include the genes GPBAR1, IL1RL1, PRKCB, and PNMT, which are associated with IBD risk, IL1RL1, with a protective effect against CD risk, and GPX1, GPBAR1, and PNMT, which are involved in UC risk.ConclusionIn a word, this study identified several potential therapeutic targets associated with the risk of IBD and its subtypes, offering new insights into the development of therapeutic agents for IBD.