bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complexity of trophic relationships between Gammarus aequicauda (Amphipoda) and Eucypris mareotica (Ostracoda) in a hypersaline lake
Authors: Shadrin Nickolai , Yakovenko Vladimir , Anufriieva Elena 
Published: April 2024

AbstractIn the hypersaline lakes of Crimea, only 5–7 species of animals are common including Gammarus aequicauda (Amphipoda) and Eucypris mareotica (Ostracoda). Two experiments were carried out to characterize the trophic interactions between these species. In one, G. aequicauda were used freshly caught from the lake, and in the other, after they were starved for 2.5 days in the laboratory. The experimental options were one male or female G. aequicauda and either 10, 20, or 30 ostracods. The gammarids actively fed on the ostracods, and significant differences were between females and males. The feeding intensity of males was higher than that of females. However, ostracods are not passive prey, they can actively attack their predator and are capable of causing them harm. Ostracods attacked a Gammarus only if it had captured one of the ostracods. Sex differences in G. aequicauda were also evident in the reaction to the group's aggressive behavior of ostracods. Interactions between Ostracoda and Gammarids cannot be considered unidirectional; they both may be prey or predators depending on the situation.
The effect of early weight‐bearing and later weight‐bearing rehabilitation interventions on outcomes after ankle fracture surgery: A systematic review and meta‐analysis of randomised controlled trials
Authors: Chen Bocheng , Ye Ziyan , Wu Jiaxin , Wang Guoxiang , Yu Tiancheng 
Published: April 2024

AbstractObjectiveThis systematic review aimed to analyse the effect of early weight bearing versus late weight bearing on rehabilitation outcomes after ankle fractures, which primarily include ankle function scores, time to return to work/daily life and complication rates.MethodsThe China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China Science and Technology Journal, Web of Science, PubMed, Embase and Cochrane Library databases were searched. The focus was on identifying randomised controlled trials centred on early weight‐bearing interventions for post‐operative ankle fracture rehabilitation. All databases were searched for eligible studies published within the period from database inception to 20 June 2023. The eligible studies were screened according to the inclusion criteria. Study quality was evaluated using the methodology recommended by the Cochrane Handbook for the Systematic Evaluation of Interventions. Two authors independently performed the literature search and data extraction. Eligible studies were subjected to meta‐analyses using Review Manager 5.3. Based on the time points at which post‐operative ankle function was reported in the studies included in this paper, we decided to perform a meta‐analysis of ankle function scores at 6 weeks post‐operatively, 12 weeks post‐operatively, 24–26 weeks post‐operatively and 1 year post‐operatively.ResultsA total of 11 papers, comprising 862 patients, were included. Meta‐analysis indicated that patients receiving early weight‐bearing interventions, which referred to weight‐bearing for 6 weeks post‐operatively, experienced enhancements in ankle function scores (Olerud–Molander score, AOFAS score or Baird–Jackson score) at various post‐operative milestones: 6 weeks (SMD = 0.69, 95% CI: 0.49–0.88 and p < 0.01), 12 weeks (SMD = 0.57, 95% CI: 0.22–0.92 and p < 0.01) and the 24–26 weeks range (SMD = 0.52, 95% CI: 0.20–0.85 and p < 0.01). The results of subgroup analyses revealed that the effects of early weight‐bearing interventions were influenced by ankle range‐of‐motion exercises. Additionally, early weight bearing allows patients to return to daily life and work earlier, which was evaluated by time when they resumed their preinjury activities (MD = −2.74, 95% CI: −3.46 to −2.02 and p < 0.01), with no distinct elevation in the incidence of complications (RR = 1.49, 95% CI: 0.85–2.61 and p > 0.05).ConclusionThe results showed that early weight bearing is effective in improving ankle function among post‐operative ankle fracture patients and allows patients to return to daily life earlier. Significantly, the safety profile of early weight bearing remains favourable, with no higher risk of complications than late weight bearing.
Work‐life balance and withdrawal behaviors among knowledge workforce: High performance work system comes into play for managing boundaries
Authors: Mathur Garima , Gulati Chanda , Sankpal Shilpa , Kee Daisy Mui Hung 
Published: April 2024

AbstractIn the wake of a turbulent era over the past 3 years, characterized by the unprecedented challenges posed by the COVID‐19 pandemic, individuals have found themselves contending with the intersection of professional and personal responsibilities. The pursuit of luxury has given way to a collective nightmare, as work and family demands converged, each equally relentless and significant. Our paper focuses on the experiences of individuals who confronted and triumphed over these challenges. A sample of 368 professionals, predominantly working from home, was examined to explore the impact of high performance work systems and boundary management in a post‐pandemic landscape marked by blurred boundaries. Our findings support the notion that effective boundary management, encompassing the management of non‐work intruding on work and work encroaching on non‐work, significantly influences withdrawal behaviors. Our study reveals the importance of organizations fostering work practices that empower employees with the IT skills to navigate virtual technologies seamlessly. By doing so, organizations can enhance work‐life balance and mitigate withdrawal behaviors among their workforces.
Next generation personalized display systems employing adaptive dynamic‐range compression techniques to address diversity in individual circadian visual features
Authors: Ohtsuka Sakuichi , Iwaida Saki , Orita Yuichiro , Hira Shoko , Kashima Masayuki 
Published: April 2024

AbstractPerceptually natural standard‐dynamic‐range (SDR) images reproduced under normal viewing conditions should retain enough information for the human observer to estimate the time at which the actual high‐dynamic‐range (HDR) scene was captured without recourse to artificial information. Currently, both global‐ and local‐tone mapping operators (TMOs) seem to have comparable levels of performance. Therefore, we first consider the constraints created in the actual human visual system by eye movement, and buttress a hypothesis with a demonstration. We briefly review the imperceptible illuminance effects yielded by the personal circadian clock suggested by chronophysiological research and other related effects, because our previous study suggested that the characteristics of the human visual system dynamically varies depending on the individual's circadian pattern. Finally, we conduct two psychophysical experiments based on the hypothesis that the human visual system employs several global TMOs at the first stage for information compression that depend on individual‐circadian‐visual‐features (ICVF). The results suggest that (1) no participant can perceive actual‐capture‐time (ACT) and (2) sensitive observers can discriminate reproduced images based on virtual‐shooting‐time (VST) effects induced by different types of global TMOs. We also discover that the VST‐based discrimination differs widely among people, but most are unaware of this effect as evidenced by daily conversations.
Ultrasound Assessment of Psoriatic Arthritis Patients With Clinically Normal Nails and Evaluation of its Correlation With the Disease Activity
Authors: Mahmoud Ines , Rouached Leila , Rahmouni Safa , Ben Dhia Siwar , Ben Tekaya Aicha , Bouden Selma , Tekaya Rawdha , Hamdi Wafa , Saidane Olfa , Abdelmoula Leila 
Published: April 2024

ObjectivesNail unit is one of the targets of ultrasound (US) assessment. We aimed to compare ultrasound parameters of clinically normal nail unit in psoriatic arthritis (PsA) patients with healthy controls (HC) and evaluate their correlations with disease activity.MethodsThis was a cross‐sectional study including patients with PsA and matched HC. Tender (TJC) and swollen joint count (SJC), Psoriasis Area and Severity Index (PASI), and Disease Activity in Psoriatic Arthritis (DAPSA) were collected in PsA patients.Patients underwent US assessment of fingernails with a study of morphological changes and measurement of the thickness of nail bed (NBT), nail plate (NPT), and adjacent skin (ST). Correlation between nail unit parameters and disease activity was studied.ResultsWe evaluated 22 PsA patients (219 nails) and 21 HC (210 nails). Mean DAPSA was 21.56 ± 14.36 and mean PASI was 2.19 ± 3.8.PsA patients had more US morphological changes than HC (16.89 vs 3.33%, P = .03). NPT comparison between identical fingernails of PsA and HC did not reveal significant difference. However, NBT was significantly higher in HC (1.77 vs 2.07 mm, P = .027) as well as ST (2.26 vs 2.59 mm, P = .003).TJC and ST were positively correlated (r = .46, P = .03). No correlation was noted between disease activity scores and NPT, NBT, or ST in PsA patients. In biologic parameters, ESR was negatively correlated with ST (r = −.41, P = .05).ConclusionsNail bed and adjacent skin US morphological changes were contributive to distinguish psoriatic from healthy nails. Adjacent skin thickness measurement was positively correlated with TJC and ESR, suggesting that it could be used as an indicator of disease activity in PsA.
Gradually Self‐Strengthen DNA Supramolecular Hydrogels
Authors: Du Xiuji , Xing Yongzheng , Li Yujie , Cao Muqing , Wu Jun , Dong Guizhi , Shi Ziwei , Wei Xunan , Qiu Miaomiao , Gao Junjie , Xu Yun , Xu Huaping , Liu Dongsheng , Dong Yuanchen 
Published: April 2024

AbstractThe dynamic mechanical strength of the extracellular matrix (ECM) has been demonstrated to play important role in determining the cell behavior. Growing evidences suggest that the gradual stiffening process of the matrix is particularly decisive during tissue development and wound healing. Herein, a novel strategy to prepare hydrogels with gradually enhanced mechanical strength is provided. Such hydrogels could maintain the dynamic properties at their initial states, such as self‐healing and shear‐thinning properties. With subsequent slow covalent crosslinking, the stability and mechanical properties would be gradually improved. This method is useful for sequence programmability and oxidation strategies, which has provided an alternated tool to study cell behavior during dynamic increase in mechanical strength of ECM.
Pharmacological characterization of allosteric modulators: A case for chemokine receptors
Authors: den Hollander Lisa S. , IJzerman Adriaan P. , Heitman Laura H. 
Published: April 2024

AbstractChemokine receptors are relevant targets for a multitude of immunological diseases, but drug attrition for these receptors is remarkably high. While many drug discovery programs have been pursued, most prospective drugs failed in the follow‐up studies due to clinical inefficacy, and hence there is a clear need for alternative approaches. Allosteric modulators of receptor function represent an excellent opportunity for novel drugs, as they modulate receptor activation in a controlled manner and display increased selectivity, and their pharmacological profile can be insurmountable. Here, we discuss allosteric ligands and their pharmacological characterization for modulation of chemokine receptors. Ligands are included if (1) they show clear signs of allosteric modulation in vitro and (2) display evidence of binding in a topologically distinct manner compared to endogenous chemokines. We discuss how allosteric ligands affect binding of orthosteric (endogenous) ligands in terms of affinity as well as binding kinetics in radioligand binding assays. Moreover, their effects on signaling events in functional assays and how their binding site can be elucidated are specified. We substantiate this with examples of published allosteric ligands targeting chemokine receptors and hypothetical graphs of pharmacological behavior. This review should serve as an effective starting point for setting up assays for characterizing allosteric ligands to develop safer and more efficacious drugs for chemokine receptors and, ultimately, other G protein‐coupled receptors.
Association of a genetic variant in angiopoietin‐like 3 with serum HDL‐C and risk of cardiovascular disease: A study of the MASHAD cohort over 6 years
Authors: Aghasizadeh Malihe , Ahmadi Hoseini Asieh , Sahebi Reza , Kazemi Tooba , Asadiyan‐Sohan Parisa , Esmaily Habibollah , Samadi Sara , Avan Amir , Ferns Gordon A. , Khosravi Saeede , Ghazizadeh Hamideh , Miri‐Moghaddam Ebrahim , Ghayour‐Mobarhan Majid 
Published: April 2024

AbstractBackgroundLoss‐of‐function (LOF) variants of the angiopoietin‐like 3 (ANGPTL3) gene are reported to be associated with serum triglyceride (TG) and high‐density lipoprotein cholesterol (HDL‐C) concentrations and thereby affect the risk of cardiovascular disease (CVD).ObjectiveIn the present study, we examined the association of rs10789117 in the ANGPTL 3 gene locus and the risk of CVD in the group of people who were part of the Mashhad‐Stroke and Heart‐Atherosclerotic‐Disorders (MASHAD) cohort.MethodsOne thousand and two healthy individuals enrolled in this study of whom 849 subjects were healthy and 153 subjects developed CVD outcomes after 6 years of follow‐up. After a 12‐h overnight fasting, 20 mL of blood samples were collected for the measurement of fasting blood glucose and lipid profile. DNA was extracted, and the Tetra‐ARMS PCR (amplification refractory mutation system) was used for genotyping of rs10789117 in the ANGPTL3 gene. The genotype frequencies of the variant of rs10789117 in the ANGPTL3 gene were estimated using χ2 tests. Eventually, the statistical analysis was done by SPSS version 20.ResultsIndividuals with AC/CC genotypes (rs10789117) were found to have to greater risk of CVD events compared to AA genotype (OR = 1.43, 95%CI = 1.01–2.02, p = 0.041). There was a 1.3‐fold increase in cardiovascular events in individuals carrying the C allele of rs10789117 variant compared to non‐carriers (OR = 1.32, 95%CI = 1.06–1.72, p value = 0.038). There were significant differences between different genotypes for serum triglyceride levels within the control group, but this difference was not significant in the group with CVD. Moreover, there was a significant association between CC genotype and CVD risk in the individuals with a normal serum HDL‐C.ConclusionWe have found that a rs10789117 C>A in ANGPTL3 gene polymorphism was associated with incident CVD events, and this may be of value as a risk stratification biomarker in CVD in the Iranian population.
A novel differential‐fed frequency beam scanning antenna with low sidelobe
Authors: Zhao Dan , Chu Hui , Li Jingkai , Li Peng 
Published: April 2024

AbstractIn this letter, a novel differential‐fed frequency beam‐scanning antenna is introduced. This differential structure is achieved by leveraging quasi‐Yagi radiating elements within a four‐layered geometry. Within this configuration, the element is excited by a pair of out‐of‐phase slow‐wave meander lines, through which differential signals are transmitted. These lines can be seamlessly integrated with other differential circuits. To ensure robust coupling, a broadside coupling structure is incorporated between adjacent layers. To corroborate theoretical insights, a prototype was constructed and tested. Measurements have shown that the primary beam can be scanned from −33.5° to +32.6° on a lateral plane, covering an operational frequency band of 9–11 GHz. Throughout this frequency range, a consistent peak gain of approximately 16.4 dBi is observed for the antenna.
A prospective study to assess the effectiveness and safety of the BlueWind System in the treatment of patients diagnosed with urgency urinary incontinence
Authors: Heesakkers John P. F. A. , Toozs‐Hobson Philip , Sutherland Suzette E. , Digesu Alex , Amundsen Cindy L. , McCrery Rebecca J. , De Wachter Stefan , Kean Emily R. , Martens Frank , Benson Kevin , Ferrante Kimberly L. , Cline Kevin J. , Padron Osvaldo F. , Giusto Laura , Lane Felicia L. , Dmochowski Roger R. 
Published: April 2024

AbstractBackgroundOveractive bladder (OAB) affects one in six adults in Europe and the United States and impairs the quality of life of millions of individuals worldwide. When conservative management fails, third‐line treatments including tibial neuromodulation (TNM) is often pursued. TNM has traditionally been accomplished percutaneously in clinic.ObjectiveA minimally invasive implantable device activated by a battery‐operated external wearable unit has been developed for the treatment of urgency urinary incontinence (UUI), mitigating the burden of frequent clinic visits and more invasive therapies that are currently commercially available.MethodsA prospective, multicenter, single‐arm, open‐label, pivotal study evaluated the safety and effectiveness of the device in adult females with UUI (i.e., wet OAB) (BlueWind Implantable Tibial Neuromodulation [iTNM] system; IDE number #G200013; NCT03596671). Results with the device were previously published under the name RENOVA iStim, which has been since renamed as the Revi™ System. Approximately 1‐month post‐implantation of the device, participants delivered therapy at their convenience and completed a 7‐day voiding diary before visits 6‐ and 12‐months post‐treatment initiation. The primary efficacy and safety endpoints were the proportion of responders to therapy ( ≥ 50% improvement on average number of urgency‐related incontinence episodes) and incidence of adverse events from implantation to 12‐month post‐activation.ResultsA total of 151 participants, mean age 58.8 (SD: 12.5), were implanted; 144 and 140 completed the 6‐ and 12‐month visits, respectively. The participants demonstrated mean baseline of 4.8 UUI/day (SD 2.9) and 10 voids/day (SD 3.3). Six and 12‐months post‐activation, 76.4% and 78.4% of participants, respectively, were responders to therapy in an intent‐to‐treat analysis. Of the 139 participants with completed 12‐month diaries, 82% were responders, 50% were classified as “dry” (on at least 3 consecutive diary days), and 93.5% of participants reported that their symptoms improved. No implanted participant experienced an SAE related to the procedure or device.ConclusionsiTNM, delivered and powered by a patient‐controlled external wearable communicating with an implant, demonstrated clinically meaningful and statistically significant improvement in UUI symptoms and a high safety profile. This therapy highlights the value of patient‐centric therapy for the treatment of UUI.
Primal‐dual active set algorithm for valuating American options under regime switching
Authors: Song Haiming , Xu Jingbo , Yang Jinda , Li Yutian 
Published: April 2024

AbstractThis paper focuses on numerical algorithms to value American options under regime switching. The prices of such options satisfy a set of complementary parabolic problems on an unbounded domain. Based on our previous experience, the pricing model could be truncated into a linear complementarity problem (LCP) over a bounded domain. In addition, we transform the resulting LCP into an equivalent variational problem (VP), and discretize the VP by an Euler‐finite element method. Since the variational matrix in the discretized system is P‐matrix, a primal‐dual active set (PDAS) algorithm is proposed to evaluate the option prices efficiently. As a specialty of PDAS, the optimal exercise boundaries in all regimes are obtained without further computation cost. Finally, numerical simulations are carried out to test the performance of our proposed algorithm and compare it to existing methods.
Exploration of a somatosensory interactive assessment tool for children with intellectual disabilities
Authors: Lu Feng , Li Panpan , Zeng Fanlin 
Published: April 2024

AbstractBased on the functional assessment concept and embodied assessment requirements, the present study aimed to design and develop an assessment tool for children with intellectual disabilities with the help of somatosensory interactive (SI) technology. The sample in this study consisted of 73 children with intellectual disabilities and 70 children with typical development. Data were collected through three SI tasks, four traditional executive function tasks, and user experience interviews to analyse the effectiveness of the SI assessment tool. The results showed that the SI assessment tool had good scale validity, discriminant validity, and the ability to identify intellectual disabilities. Children preferred SI tasks and showed higher involvement and more positive emotions. The SI tool with three SI tasks is a more scientific, effective, and advanced tool for assessing children with intellectual disabilities.
Artificial intelligence‐based diagnosis in fetal pathology using external ear shapes
Authors: Hennocq Quentin , Garcelon Nicolas , Bongibault Thomas , Bouygues Thomas , Marlin Sandrine , Amiel Jeanne , Boutaud Lucile , Douillet Maxime , Lyonnet Stanislas , Pingault Vèronique , Picard Arnaud , Rio Marlèe , Attie‐Bitach Tania , Khonsari Roman H. , Roux Nathalie 
Published: April 2024

AbstractObjectiveHere we trained an automatic phenotype assessment tool to recognize syndromic ears in two syndromes in fetuses—=CHARGE and Mandibulo‐Facial Dysostosis Guion Almeida type (MFDGA)—versus controls.MethodWe trained an automatic model on all profile pictures of children diagnosed with genetically confirmed MFDGA and CHARGE syndromes, and a cohort of control patients, collected from 1981 to 2023 in Necker Hospital (Paris) with a visible external ear. The model consisted in extracting landmarks from photographs of external ears, in applying geometric morphometry methods, and in a classification step using machine learning. The approach was then tested on photographs of two groups of fetuses: controls and fetuses with CHARGE and MFDGA syndromes.ResultsThe training set contained a total of 1489 ear photographs from 526 children. The validation set contained a total of 51 ear photographs from 51 fetuses. The overall accuracy was 72.6% (58.3%–84.1%, p < 0.001), and 76.4%, 74.9%, and 86.2% respectively for CHARGE, control and MFDGA fetuses. The area under the curves were 86.8%, 87.5%, and 90.3% respectively for CHARGE, controls, and MFDGA fetuses.ConclusionWe report the first automatic fetal ear phenotyping model, with satisfactory classification performances. Further validations are required before using this approach as a diagnostic tool.