bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Issue of Alexei I Komnenos’ Environment
Authors: Дробышев М.И. 
Published: April 2024

В статье рассматривается окружение византийского императора Алексея I Комнина (1056 / 1057–1118), воссозданное по источникам его эпохи («Алексиаде» Анны Комнины [1083–1053], «Типикону» Григория Пакуриана [ум. 1086 г.] и другим). В контексте византийской историографии и современной византинистики обсуждаются факты из жизни наиболее ярких представителей Востока – Григория Пакуриана и Татикия (ок. 1056 – п. 1099). Изучается их происхождение, карьерный путь, практика инкорпорирования в социальную и политическую структуру Ромейской империи.
The paper examines the environment of the Byzantine emperor Alexios I Komnenos (1056 / 1057–1118), reconstructed on sources of his epoch (“Alexias”of Anna Comnenae [1083–1053], “Typicon” of Gregory Pacurianus [d. 1086] and others). In the context of Byzantine historiography and modern Byzantine studies, facts from the life of the most prominent representatives of the East – Gregory Pakurian and Tatikios (c. 1056–1099) are discussed. Information on their origins is analyzed, their careers and the practice of inclusion in the social and political structure of the Roman Empire are studied.
The Grounded Theory Methodology as a Research Tool in Intellectual History
Authors: Власов Н.А. 
Published: April 2024

Современные исторические исследования могут значительно выиграть от привлечения методологических инструментов смежных социальных наук. Одним из них является «обоснованная теория», широко распространенная в сфере социологии. В статье дается обзор развития данной методологии, ее основных современных направлений, а также описание процесса исследования в соответствии с принципами «классической» школы «обоснованной теории». Отдельно рассматривается опыт применения методологии в такой области знания, как исследования современных международных отношений, где «обоснованная теория» использовалась для реконструкции представлений и взглядов коллективных акторов. Делается вывод о том, что методы «обоснованной теории» могут успешно применяться и при изучении интеллектуальной истории и социальных процессов прошлого. Кроме того, отдельные инструменты из арсенала данной методологии могут использоваться в рамках других исследовательских подходов для решения более широкого спектра задач.
The recent historical research could greatly benefit from the use of methodological tools borrowed from other social sciences. One of those tools is the Grounded Theory methodology, widely used in sociological research. The article provides an overview of the development of this methodology, as well as description of the research process in accordance with the principles of the "classical school" of Grounded Theory. The experience of applying this methodology in the study of international relations is taken into close consideration as especially illustrative. Grounded Theory was used there to reconstruct the ideas and views of collective actors. The conclusion is that the methodology of Grounded Theory could be successfully used in historical science, particularly in the study of social processes. In addition, some tools from the “toolbox” of this methodology may be used in the framework of alternative approaches to cover a significantly broader range of research questions.
Effectiveness of Sea Cucumber Viscera Waste to Improve Reproductive Performance of Male Tiger Shrimp (Penaeus monodon)
Authors: Hidayani Andi Aliah , Achmad Marlina , Fujaya Yushinta , Permatasari Nur Umriani , Lante Samuel , Bahruddin Latifa , Suwanmala Jitima , Azzahra Sitti Fatimah , Jannati Alifah Nurul 
Published: April 2024

Tiger shrimp has received attention because of the high prices. However, sustainable cultivation of tiger shrimp is still hampered by the low quality of spermatozoa in male broodstock. Sea cucumbers are a type of invertebrate that is very useful because they have many viscera with almost the same nutritional content as fresh food. However, it has other advantages compared to other fresh feeds, namely it has a very high testosterone content so that it can be used to improve the quality and quantity of spermatozoa of male tiger prawns. The study aims to compare the influence between sea cucumber viscera and fresh squid as well as the combination of sea cucumber and squid viscera against the density of tiger shrimp spermatozoa (Penaeus monodon). Test animals used were 18 male tiger shrimp with an average weight of 80.93 g. Shrimp are kept in tanks with a volume of 1 ton, with a density of 3 broodstock/tank and 3 replications. Feeding was carried out with a frequency of 3 times a day and at a dose of 20% of biomass for 30 days. The test feed used consisted of 100% fresh squid feed as a control, a combination of 50% squid and 50% of sea cucumber viscera, and 100% of sea cucumber viscera. The administration of sea cucumber visceral waste in tiger shrimp tend to increase the quantity of spermatozoa tiger shrimp.
Analysis and optimization of pre-stressed modal features of ship anchor support parts
Authors: Liu Xiaoyu , Wu Xiangyao , Calderon Aldrin D. 
Published: April 2024

In order to solve the problems of excessive weight and unreasonable structure of anchor machine parts caused by traditional design methods, a lightweight optimization method was proposed based on pre-stressed modal analysis. The design variables were determined, and the parameterized model was established by using ANSYS Workbench. Under ultimate load conditions, the strength of wall frame board and lower box bodies was simulated and calculated. Through modal analysis, the discretized natural frequencies under different design variables could be obtained. The multi-objective genetic algorithm and sequence quadratic programming were respectively used to calculate the lightweight analysis model. The results showed that the weight of the supporting components in ship anchor can be reduced by more than 5 % without reducing strength and equivalent stiffness.
Antihyperlipidemic and antioxidant potential of Olea europaea L. leaves: An experimental study in vivo, in vitro and in silico
Authors: Amraoui Abdelatif , Djerrou Zouhir , Ali Haimoud Safia , Zerouki Khayra , Elmokli Soumia 
Published: April 2024

Hyperlipidemia is an enduring metabolic ailment that affects glucose and lipid processing.
The research objective was to measure the total phenolic, flavonoid, and tannin contents in Olea europaea L. leaves and to to identify their antioxidant and antihyperlipidemic potential. The study included an in silico model of interaction for hydroxytyrosol, oleuropein, and xanthine dehydrogenase. The in vivo experiment involved rabbits that received olive leaves (150 mg/kg) and 10 mL of egg yolk as a high-fat diet. At the end of the experimental period, blood samples were tested for lipid profile, and tissue specimens were used for liver histology.
The total phenolic content was 119.84 ± 3.86 mg GAE/g, the total flavonoid content was 2.22 ± 0.07 mg CE/g, and the total tannin content was 21.25 ± 1.24 mg REQ/g dry weight. According to DPPH and FRAP analyses, the antioxidant capacities were 0.34 ± 0.06 μg/mL and 6.35 ± 0.52 μmol Fe(II)/g dry weight, respectively. In the experimental animals, O. europaea leaves reduced such parameters as total cholesterol, low-density lipoprotein, total triglycerides, total cholesterol vs. high-density lipoprotein, and low-density lipoprotein vs. high-density lipoprotein. The histopathological liver assay showed no signs of tissue damage while the samples obtained from the control group demonstrated steatosis deposits and cellular necrosis. Based on the energy and RMSD results, hydroxytyrosol proved an effective xanthine dehydrogenase inhibition.
These findings constitute a good scientific basis for the complementary future research on the potential of O. europaea leaves as ingredients of functional foods or medical drugs.
Assessment of non-revenue water in the urban water distribution system network in Cameroon (Central Africa)
Authors: Ngueyim Nono Karel Josy , Dang Mvongo Victor , Defo Celestin 
Published: April 2024

ABSTRACTThis paper aims to assess non-revenue water (NRW) in the urban water distribution system in Cameroon. The methodological approach used in this study was based on online searches using the databases such as Google Scholar, Web of Science, PubMed, and the International Water Association. These online searches have been completed through field observations and interviews with institutional and non-institutional stakeholders in the urban water sector. Results indicate that the total volume of NRW in the urban area of Cameroon was 100.26 million m3/year, which represents 52.5% of the total system input volume. About 2 million people could be supplied by cutting Cameroon's NRW to half the present level. Findings also suggest that the water utility (Camwater) practices passive leakage control, meaning that Camwater repairs only those leaks that are visible. Reducing NRW can be achieved through leakage detection and pipe replacement, pressure management, water metering, and a program to identify, remove, and replace illegal connections.
Enhancing hydrological modeling with transformers: a case study for 24-h streamflow prediction
Authors: Demiray Bekir Zahit , Sit Muhammed , Mermer Omer , Demir Ibrahim 
Published: April 2024

ABSTRACT

In this paper, we address the critical task of 24-h streamflow forecasting using advanced deep-learning models, with a primary focus on the transformer architecture which has seen limited application in this specific task. We compare the performance of five different models, including persistence, long short-term memory (LSTM), Seq2Seq, GRU, and transformer, across four distinct regions. The evaluation is based on three performance metrics: Nash–Sutcliffe Efficiency (NSE), Pearson's r, and normalized root mean square error (NRMSE). Additionally, we investigate the impact of two data extension methods: zero-padding and persistence, on the model's predictive capabilities. Our findings highlight the transformer's superiority in capturing complex temporal dependencies and patterns in the streamflow data, outperforming all other models in terms of both accuracy and reliability. Specifically, the transformer model demonstrated a substantial improvement in NSE scores by up to 20% compared to other models. The study's insights emphasize the significance of leveraging advanced deep learning techniques, such as the transformer, in hydrological modeling and streamflow forecasting for effective water resource management and flood prediction.
Diabetic Retinopathy: Diverse Perspectives of Available Herbal
Resolutions
Authors: Pal Rashmi Saxena , Pal Yogendra , Chaitanya MVNL , Bhasin Aparajita , Srivastava Preeti 
Published: April 2024

Abstract:
Uncontrolled blood sugar levels bring on an eye condition known as diabetic retinopathy.
If untreated, the damage to the blood vessels in the retina can result in blindness. Early symptoms
include impaired vision, difficulties distinguishing colours, and dark patches of vision. Since ancient
times, people all around the world have utilized herbs to manage diabetes and the various additional
problems it might cause. Numerous herbs, including Salvia, Ginseng, Gingko, and Scrophularia ningpoensis,
have unique qualities that make them capable of lowering the various pathological incidences
of hyperglycemia-related retinal disease. Biomolecules, known as carotenoids, such as lutein, beta
carotene, and zeaxanthin, have a significant anti-oxidant capability that aids in visual recovery. In
addition to acting as a natural and safe treatment for diabetic retinopathy, herbal remedies in the form
of herbs, concentrated extracts, and isolated phytoactives can also operate as a viable alternative to
prevent the destruction brought on by laser-based photocoagulation and vitrectomy. The goal of the
current study is to analyze the natural herb-based alternatives for diabetic retinopathy that are now
available.
The Inhibitory Effects of Propofol on Colorectal Cancer Progression through the
NF-κB/HIF-1α Signaling Pathway
Authors: Yao Liuxu , Zhai Wen , Jiang Zongming , He Rui , Xie Weiying , Li Yuhong , Hu Yiyang 
Published: April 2024

Background and Objective:
Colorectal cancer (CRC) is a neoplastic disease that gradually develops
due to genetic variations and epigenetic changes. Surgical excision is the first-line treatment for CRC. Accumulating
evidence has shown that total intravenous anesthesia has beneficial effects for CRC patients as it decreases
the probability of tumor recurrence and metastasis. Propofol is one of the most frequently used intravenous anesthetics
in clinical practice. However, it remains unknown whether it can reduce recurrence and metastasis after
surgery in cancer patients.

Methods:
CRC cell lines (HCT116 and SW480) were cultured in vitro, and different concentrations of propofol
were added to the cell culture medium. The proliferation effect of propofol on CRC cell lines was evaluated by
CCK-8 assay. The effect of propofol on the migration and invasion of CRC cells was evaluated by scratch healing
and Transwell experiments. The inhibitory effects of propofol on NF-κB and HIF-1α expressions in CRC cell
lines were determined by Western blotting and immunofluorescence assays to further clarify the regulatory effects
of propofol on NF-κB and HIF-1α.

Results:
Compared to the control, propofol significantly inhibited the proliferation, migration, and invasion abilities
of CRC cells (HCT116 and SW480) (p < 0.0001). The expression levels of NF-κB and HIF-1α gradually
decreased with increasing propofol concentration in both cell lines. After activation and inhibition of NF-κB, the
expression of HIF-1α changed. Further studies showed that propofol inhibited LPS-activated NF-κB-induced
expression of HIF-1α, similar to the NF-κB inhibitor Bay17083 (p < 0.0001).

Conclusion:
In vitro, propofol inhibited the proliferation, migration, and invasion of CRC cells (HCT116 and
SW480) in a dose-dependent manner, possibly by participating in the regulation of the NF-κB/HIF-1α signaling
pathway.
Immunological Implications in Diabetes: A Review on Various Diseases and Conditions
Authors: Upadhyay Sanskriti , Mazumder Avijit , Pentela Bhavani , Bansal Priyanka , Agarwal Neeraj , Singh Baghel Dileep 
Published: April 2024

:
Diabetes Mellitus (DM) is a long-term metabolic condition that has significant social,
health, and economic consequences. There are various forms of diabetes mellitus, but the two most
common varieties are type I and type II. Insulin-dependent diabetes (IDDM) is one of the most wellknown
autoimmune illnesses that cause insulin insufficiency and hyperglycemia by either damaging
or destroying Langerhans' beta cells. Available scientific data evidenced the greatest genetic contribution
of Human Leukocyte Antigen class II in the IDDM. Hyperglycemia and individual components
of the insulin resistance (metabolic) syndrome put people with type II diabetes at increased risk
for microvascular consequences (retinopathy, nephropathy, and neuropathy) as well as macrovascular
issues (cardiovascular comorbidities). A number of pathophysiological abnormalities, including
obesity, poor diet, and physical inactivity, as well as genetic variables, are involved in the disturbed
glucose homeostasis associated with type II diabetes. Diseases like lipid abnormalities contribute to
the progression of diabetes, whereas obesity and its related medical disorders (such as hypertension,
diabetes, insulin resistance, and sleep apnea syndrome) are eventually linked to an elevated cardiovascular
risk. Diabetes raises the incidence, intensity, and duration of peri-densities in people with
diabetes compared to healthy persons, making it a risk factor for periodontal disease. Diabetes conditions
in patients concurrently also increase the progression or risk of other diseases, i.e., cardiovascular-
related diseases (hypertension, oxidative stress, hyperlipidemia), nervous system-related diseases,
and COVID-19, by increasing the overall infection rate. There is widespread evidence that correlates
the direct connection between diabetes and other diseases, including immunity disorders, CVS disorders,
etc. This review provides a correlation between diabetes and another disease with an overall
impact on the progression of cardiovascular diseases, neurological diseases, COVID-19, and periodontal
diseases. This current review focuses on the collation of some plants that show antidiabetic
activity, including plant part, family, chemical constituent, mechanism of action, and chemical used
for extraction. Studies on the role, causes, clinical management, prevention, and treatment of diabetes
heavily rely on epidemiological evidence. This review also explains different factors responsible
for diabetes, like genetic factors, environmental factors, and viral infections.
Framework for Image Denoising Employing Different Thresholding
Techniques
Authors: Bharti Monika , Jain Shruti , Jindal Himanshu 
Published: April 2024

Background:
Noise represents a lack of data in the image which can be removed using
Image denoising. Image denoising can be achieved by Gaussian filtering, anisotropic filtering,
wavelet Thresholding, etc.

Objective:
In this paper, authors have used Wavelet-based denoising because it can effectively remove
both additive and multiplicative noise from images, and preserve fine details and edges in the
image.

Methods:
The different thresholding techniques like Visu Shrink and Bayes Shrink for Hard
Thresholding (HT) and Soft Thresholding (ST) employing different standard deviations ranging
from 0.05-0.3 with a difference of 0.05 is used.

Results:
The peak signal-to-noise ratio (PSNR) is evaluated as a performance parameter. For grayscale
images, the maximum value of PSNR is obtained as 29.483 dB while for RGB images,
34.324dB using Bayes Shrink considering ST at 0.05 variance is achieved. 2.2% improvement is
observed for grayscale images while 8.6% improvement is observed for RGB images considering
Bayes Shrink ST over Bayes Shrink HT.

Conclusion:
While comparing PSNR values of other Thresholding techniques, ST results better
over HT. The PSNR values for images produced by Bayes Shrink are high which therefore states
that the quality of reconstructed images is better for Bayes Shrink than Visu Shrink.
Non-Invasive Specimen Collection in COVID-19 RT-PCR Testing: An Observational Study at an Indonesian Tertiary Hospital
Authors: Putra Andika Chandra , Zaini Jamal , Ningrum Ratih Asmana , Ridwanuloh Asep Muhammad , Nugroho Herjuno Ari , Setyawan Ryan Haryo , - Idris , Setiawan Ruby , Sushadi Pangda Sopha , Wulandari Ari Sulistyo , Zannati Anky , - Indriawati , Erdayani Eva , - Wahyuni , Agustiyanti Dian Fitria , Wisnuwardhani Popi Hadi , Saniyyah Zahrah , Haryanto Budi , Utomo Ahmad Rusdan Handoyo , Setyaputri Novia Ayu Rahma 
Published: April 2024

Background:
COVID-19 is a disease of SARS-CoV2 beta coronavirus infection. One way
to control the progression of COVID-19 symptoms is a rapid and accurate diagnosis. The current
gold standard of COVID-19 diagnostic method uses RT-PCR from nasopharyngeal (NP) swabs and
sputum specimens.

Objective:
To assess the efficacy of saliva and rectal swabs as non-invasive alternatives to the conventional
nasopharyngeal swab for RTPCR testing in COVID-19 diagnosis, with a focus on the potential
benefits for healthcare providers and patient comfort.

Methods:
This observational study was conducted with 80 confirmed cases at a tertiary hospital in
Indonesia, the study compared RTPCR positivity rates among different collection methods.

Results:
A high positivity rate of 92% for nasopharyngeal swabs, with saliva and rectal swabs yielding
36% and 34%, respectively. Notably, the positivity rates for saliva and rectal samples increased
to 60% and 50% when testing occurred between five to seven days post-symptom onset. Crucially, in
older patients, both saliva and rectal swabs demonstrated higher positivity rates than in younger patients
within the initial four days of symptom onset, with rates of 43% and 17%, respectively. Furthermore,
a significant correlation was found between rectal swab positivity on day one and mortality
in the older cohort, where lower Ct values on day seven were significantly associated with the
deceased group.

Conclusion:
These findings support the potential of saliva and rectal swabs in predicting disease
severity and patient outcomes, suggesting a safer and more convenient testing strategy for COVID-
19.
Enchanting Math AudibleBook: Insights from Teachers, University Students, and Young Learners
Authors: Alim Jesi Alexander , Oktaviani Cici , Hermita Neni , Putra Zetra Hainul 
Published: April 2024

Reading is an essential activity of learning. In this study, the researchers investigated the opinions of elementary school teachers, university students majoring in elementary school teacher education, and elementary school students on the mathematics audible book "Asyiknya Bermain Setatak”. The researchers distributed questionnaires to collect the data. Data collection was carried out randomly using the random sample method. The respondents comprised 75 people (9 elementary school teachers, 53 university students majoring in elementary school teacher education, and 13 elementary school students) in Pekanbaru, Riau. The data were analyzed using Rasch Model with item response theory (IRT). Based on the data analysis, all statements are valid and reliable, and it means that the items can be used to judge the design of the audible book "Asyiknya Bermain Setatak".Based on the results of the study, it was found that the audible book math media was in accordance with the learning of elementary school students. The use of math audible book is also easy to do by students, teachers, and prospective teachers. Math audible books also provide positive benefits in learning mathematics. Based on this, it can be concluded that teachers should consider using audible books as a media for mathematics learning.
Evaluation of an e-Learning Program for Community Pharmacists for Dispensing Emicizumab (Hemlibra) in France: Nationwide Cross-Sectional Study (Preprint)
Authors: Chamouard Valérie , Freyssenge Julie , Clairaz-Mahiou Béatrice , Ferrera Bibas Felicia , Fraticelli Laurie 
Published: April 2024

BACKGROUND

Since June 2021, patients with hemophilia A with antifactor VIII inhibitors and those with severe hemophilia A without antifactor VIII inhibitors treated with Hemlibra have had to choose between a community or hospital pharmacy. The French reference center for hemophilia developed the HEMOPHAR e-learning program for community pharmacists for dispensing emicizumab.

OBJECTIVE

This study aims to evaluate the efficiency and safety of this new care pathway by assessing the HEMOPHAR e-learning program.

METHODS

The methodology is based on Kirkpatrick’s model for evaluating the immediate reaction of trained community pharmacists (level 1), their level of acquired knowledge (level 2), and their professional practice after 3 months of dispensation (level 3).

RESULTS

The HEMOPHAR e-learning program reached a large audience, with 67% (337/502) of the eligible community pharmacists following it. The immediate reaction was overall satisfying. High rates of engagement were reported with 63.5% (214/337) to 73.3% (247/337) of completed training modules, along with high rates of success with quizzes of 61.5% (174/337) to 95.7% (244/337). We observed that 83.9% (193/230) of the community pharmacists needed less than 2 attempts to pass the quiz of the module related to professional practice, while the other quizzes required more attempts. Advice on compliance and drug interactions were most frequently provided to patients by the community pharmacists.

CONCLUSIONS

This study suggests ways to improve the training of community pharmacists and to optimize coordination with treatment centers. This study also reports on the feasibility of switching to a community pharmacy in a secure pharmaceutical circuit, including in the context of a rare bleeding disease.

CLINICALTRIAL

ClinicalTrials.gov NCT05449197; https://clinicaltrials.gov/study/NCT05449197

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/43091