bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen partitioning between stishovite and hydrous phase δ: implications for water cycle and distribution in the lower mantle
Authors: Ishii Takayuki , Criniti Giacomo , Purevjav Narangoo , Katsura Tomoo , Ohtani Eiji 
Published: February 2024

AbstractWater is transported into the deep mantle by subducting slabs, playing important roles in mantle dynamics and evolution. An aluminous hydrous mineral, phase δ with a main component of AlOOH, has been considered an important water carrier in the lower mantle. Recent studies reported that SiO2 stishovite can accommodate weight percent levels of water, indicating another important water carrier in the lower mantle. However, which mineral can mainly carry water is not clear yet. Recent hydrous phase relation studies reported that stishovite is depleted in alumina when coexisting with hydrous phase δ, in which water content of stishovite was not investigated. In this study, we investigated hydrogen partitioning between stishovite and hydrous phase δ at 24–28 GPa and 1000–1200 °C by means of Kawai-type multi-anvil press in combination with Fourier-transform infrared spectroscopy at ambient conditions on recovered samples. Fourier-transform infrared spectra of recovered stishovites showed that water contents of stishovite coexisting with hydrous phase δ were limited to up to ~ 500 ppm. This indicates that coexisting hydrous phase δ causes not only depletion in alumina but also in hydrogen in stishovite and therefore mainly transports water in a cold subducting slab. Once hydrous phase δ becomes thermally unstable, alumina and water contents in silica minerals are increased by the chemical reaction between SiO2 and AlOOH, and aluminous silica minerals such as stishovite and CaCl2-type phase will be a main water carrier in the lower mantle. Presence of small-scale seismic scatterers observed around 1900 km depth, which was considered to be caused by a transition from almost pure SiO2 stishovite to CaCl2-type phase, might also be able to be explained by the phase transition of stishovite coexisting with hydrous phase δ.
Effects of employee engagement on organizational performance: case of public universities in Ethiopia
Authors: Gede Dawit Udessa , Huluka Admassu Tesso 
Published: February 2024

AbstractThe objective of this research is to examine the impact of Employee Engagement on Organizational Performance within Public Universities in Ethiopia. It aims to explore the relationship between employee engagement and the overall performance of these institutions, specifically focusing on public universities. By providing significant insights and recommendations, this research will contribute towards the development of strategies that can enhance employee engagement and improve the overall performance of Ethiopian public universities. The study utilized both quantitative and qualitative approaches, employing descriptive and explanatory research designs. To gather data, three Ethiopian universities were selected based on their establishment date, and a random selection technique was used to include 365 personnel in the sample. Descriptive statistical tools like mean and standard deviation were employed, while structural equation models were utilized for confirmatory factor analysis and path analysis. The study's findings indicate that vigor, dedication, and absorption all have a significant and favorable impact on organizational performance in higher education. The study findings also indicate that the performance of study institutions differs based on the extent of employee involvement. This research introduces a fresh perspective of the relationship between employee engagement and organizational performance by concentrating specifically on the context of public universities in Ethiopia. This sheds light on the distinctive dynamics and obstacles encountered by these institutions. Furthermore, the study adds to the current body of knowledge by exploring the relationship between employee engagement and organizational performance, offering valuable insights and suggestions to enhance performance in the setting of Ethiopian public universities.
Striving for a life out of shadows: informal entrepreneurial dynamics in time of crisis
Authors: Yana Mbena Jacques , Yeboah Kwabena Obiri 
Published: February 2024

AbstractMotivated by the unique opportunity that a crisis period provides for capturing and reassessing specific entrepreneurial behaviors, this paper takes on the debate about the entrepreneurial attributes of informal ventures “IVent” and their endeavor to formalize. In doing so, Cronbach’s alpha rationales and contingency analysis are applied to quantitative data from street vendors of the main markets of Cameroon to investigate informal entrepreneurial behavioral dynamics and their impact on a hypothetical willingness for change during the COVID-19 pandemic. It was uncovered that IVent have activated entrepreneurial attributes of resilience, intention and orientation. Also, specific composites or variables of entrepreneurial orientation and resilience have been found more supportive of IVent’s endeavor to formalize than others. The novelties in that regard are: (1) While most of the variables related to the composite of innovativeness reinforce the desire to formalize, the variable of “routine” plays a hindering role. (2) The composite of proactiveness is not significantly related to the willingness to formalize. (3) The composite of risk-taking has proven significant to IVent’s transformation aims. And (4) contrary to all other variables of the attribute of resilience and self-efficacy, the variable of behavior control appears to hamper the aim to move out of the shadows. It is argued that facilitating Ivent’s dynamics and aspiration to formalize necessitates policymakers to advance policies that support the development of the uncovered determining composites. Furthermore, academia should undertake an extensive investigation into the role that the captured non-significant variables, attributes, and composites may play in fostering IVent's shadowed business lifecycle.
Graphical abstract
Ties that bind: exploring corporate networks, decision-making dynamics in the financial market, labor-management relations, and organizational performance
Authors: da Silva Emerson Jorge , Ramos Fernando Maciel , Cembranel Priscila , Witt Cleonice 
Published: February 2024

AbstractCorporate governance relies significantly on the board of directors, who act as custodians of shareholders' interests. The dynamics of social connections between Chief Executive Officers (CEOs) and board members form a critical element that influences information exchange within this vital governance structure. This study seeks to assess the impact of these social connections on organizational performance. We conducted a comprehensive analysis of the professional backgrounds of CEOs and board members to measure the extent of their social connections. Employing multiple regression analysis with robust error corrections, we considered essential economic and financial metrics, including Return on Assets (ROA), Return on Equity (ROE), and Earnings before Interest, Taxes, Depreciation, and Amortization (EBITDA). Our findings reveal that professional social connections have a positive influence on ROA (β = 0.0230|p-value ≤ 0.05) and EBITDA (β = 420,517,1|p-value ≤ 0.05), while educational connections exhibited no significant effect, and familial connections were found to adversely affect EBITDA (β = − 516,307,0|p-value ≤ 0.05). This study highlights the real influence of social connections on firm performance, shedding light on the complex interplay between social dynamics and corporate success. These insights contribute to a more comprehensive understanding of corporate governance and the factors driving organizational performance.
Graphical abstract
Understanding the impact of human capital on radical and incremental innovation: the role of entrepreneurial passion and alertness
Authors: Rafique Tayyaba , Mohsin Muhammad , Abid Muhammad Adeel , Ashrif Ali Noman , Anwar Saliah 
Published: February 2024

Abstract
Purpose
The present study sought to comprehend the impact of human capital on radical and incremental innovation, with a focus on examining the mediating effects of entrepreneurial passion and entrepreneurial alertness.

Design/methodology/approach
The study employed a purposive sampling technique for collecting data from entrepreneurs in from different sectors of Pakistan. A sample of 382 entrepreneurs completed the survey. Data were analyzed using SPSS and AMOS. Reliability, discriminant, and convergent validity tests were conducted, and structural equation modeling was used to test the hypotheses.

Findings
It was revealed that human capital has a significant impact on radical and incremental innovation. Furthermore, entrepreneurial passion and alertness significantly mediates the relationship between human capital and innovation.

Originality/value
The study contributes to the emerging research on innovation in entrepreneurship. There is limited research on types of innovation and entrepreneurial alertness in Pakistan; therefore, the study adds value to the scarce empirical research on innovation and entrepreneurial alertness and passion.
Glucocorticoid use in psoriatic arthritis and treatment outcomes: does the gender have a role?
Authors: Bayrak Esra Dilsat , Aktas Ilknur 
Published: February 2024

Abstract
Background
Systemic glucocorticoids are commonly used in practice in the treatment of psoriatic arthritis. However, authorities advise against prescribing it, primarily because of the risk of psoriasis flare-ups. The authors aimed to assess the glucocorticoid use in psoriatic arthritis (PsA), factors associated with the use of glucocorticoids and to uncover whether gender has an impact on glucocorticoid use and treatment responses. Disease-modifying antirheumatic drug (DMARD)-naive PsA patients were included in this cross-sectional study. Baseline clinical and demographic characteristics were recorded. After starting DMARD treatment, patients were followed for 2 years. The number of patients who started glucocorticoids, the clinical demographics of these patients, the duration of glucocorticoid administration, and the dose for administration were recorded. Patient outcomes and gender differences were analyzed. Disease activity was measured using the Disease Activity Scale 28 (DAS28-CRP) and the Disease Activity Index for Psoriatic Arthritis (DAPSA).

Results
Fifty-five of the 141 patients (39%) received glucocorticoids at the 2-year follow-up. There was no difference between the sexes who are in remission-low disease activity (LDA) on cDMARD monotherapy (p = 0.300). Glucocorticoid usage (p = 0.660), dose (p = 0.054), and duration (p = 0.159) did not differ between male and female patients. Higher glucocorticoid doses were associated with dactylitis, higher CRP levels, higher DAS-28 and DAPSA scores, and longer (> 3 months) glucocorticoid administration. Glucocorticoid duration was longer in patients with higher TJS, SJS, serum CRP, higher DAS-28 and DAPSA scores, and higher glucocorticoid doses. Sustained remission-LDA was achieved in 16 of 55 patients after cessation of glucocorticoids and no sex difference was observed.

Conclusion
Systemic glucocorticoids are commonly prescribed in PsA, and when added to treatment even for short periods and in low doses, they help achieve significant disease control. Except for axial involvement, there is no difference in treatment responses between male and female patients, making it unnecessary to make a gender distinction in the treatment algorithm. Given these findings, prospective studies are needed to evaluate glucocorticoids as a bridging treatment in PsA, such as rheumatoid arthritis.
Topical Diclofenac for Prevention of Capecitabine-Associated Hand-Foot Syndrome: A Double-Blind Randomized Controlled Trial
Authors: Santhosh Akhil , Sharma Atul , Bakhshi Sameer , Kumar Akash , Sharma Vinod , Malik Prabhat Singh , Pramanik Raja , Gogia Ajay , Prasad Chandra Prakash , Sehgal Tushar , Gund Sneha , Dev Arundhathi , Cheung Winson Y. , Pandey R.M. , Kumar Saran , Gupta Ishaan , Batra Atul ,   on behalf of the D-TORCH Trial Investigators
Published: February 2024

PURPOSE Hand-foot syndrome (HFS) is a dose-limiting side effect of capecitabine. Celecoxib prevents HFS by inhibiting cyclooxygenase-2 (COX-2) that is upregulated because of the underlying associated inflammation. However, systemic side effects of celecoxib have limited routine prescription. Topical diclofenac inhibits COX-2 locally with minimal risk of systemic adverse events. Therefore, we conducted this study to assess the efficacy of topical diclofenac in the prevention of capecitabine-induced HFS. METHODS In this single-site phase III randomized double-blind trial, we enrolled patients with breast or GI cancer who were planned to receive capecitabine-based treatment. Participants were randomly assigned in a 1:1 ratio to receive topical diclofenac or placebo gel for 12 weeks or until the development of HFS, whichever occurred earlier. The primary end point was the incidence of grade 2 or 3 HFS (Common Terminology Criteria for Adverse Events version 5), which was compared between the two groups using simple logistic regression. RESULTS In total, 264 patients were randomly assigned to receive topical diclofenac gel (n = 131) or placebo (n = 133). Grade 2 or 3 HFS was observed in 3.8% of participants in the diclofenac group compared with 15.0% in the placebo group (absolute difference, 11.2%; 95% CI, 4.3 to 18.1; P = .003). Grade 1-3 HFS was lower in the diclofenac group than in the placebo group (6.1% v 18.1%; absolute risk difference, 11.9%; 95% CI, 4.1 to 19.6). Capecitabine dose reductions because of HFS were less frequent in the diclofenac group (3.8%) than in the placebo group (13.5%; absolute risk difference, 9.7%; 95% CI, 3.0 to 16.4). CONCLUSION Topical diclofenac prevented HFS in patients receiving capecitabine. This trial supports the use of topical diclofenac to prevent capecitabine-associated HFS.
Circulating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors
Authors: Hu Yiduo , Narayan Azeet , Xu Yunshan , Wolfe Julia , Vu Dennis , Trinh Thi , Kantak Chaitanya , Ivy S. Percy , Eder Joseph Paul , Deng Yanhong , LoRusso Patricia , Kim Joseph W. , Patel Abhijit A. 
Published: February 2024

PURPOSE Cell-free circulating tumor DNA (ctDNA) has shown its potential as a quantitative biomarker for longitudinal monitoring of response to anticancer therapies. However, ctDNA dynamics have not been studied in patients with heavily pretreated, advanced solid tumors, for whom therapeutic responses can be weak. We investigated whether changes in ctDNA could predict clinical outcomes in such a cohort treated with combined poly(ADP-ribose) polymerase/vascular endothelial growth factor receptor inhibitor therapy. MATERIALS AND METHODS Patients with metastatic pancreatic ductal adenocarcinoma (PDAC), triple-negative breast cancer (TNBC), small-cell lung cancer (SCLC), or non–small-cell lung cancer (NSCLC) received up to 7 days of cediranib 30 mg orally once daily monotherapy lead-in followed by addition of olaparib 200 mg orally twice daily. Patients had progressed on a median of three previous lines of therapy. Plasma samples were collected before and after cediranib monotherapy lead-in and on combination therapy at 7 days, 28 days, and every 28 days thereafter. ctDNA was quantified from plasma samples using a multigene mutation–based assay. Radiographic assessment was performed every 8 weeks. RESULTS ctDNA measurements were evaluable in 63 patients. The median baseline ctDNA variant allele fractions (VAFs) were 20%, 28%, 27%, and 34% for PDAC, TNBC, SCLC, and NSCLC, respectively. No association was observed between baseline VAF and radiographic response, progression-free survival, or overall survival (OS). Similarly, no association was found between ctDNA decline and radiographic response or survival. However, an increase in ctDNA at 56 days of combination therapy was associated with disease progression and inferior OS in a landmark analysis. CONCLUSION ctDNA levels or dynamics did not correlate with radiographic response or survival outcomes in patients with advanced metastatic malignancies treated with olaparib and cediranib.
All-Cause Mortality Differentials by Diabetes Status and Serum Neurofilament Light-Chain Levels in US General Adults
Authors: Cai Yingyuan , Wei Qian , Wang Shan , Lu Xiaowei 
Published: February 2024

Abstract

Context
Neurofilament light chains (sNFLs) increase in patients with diabetes (DM) and are associated with death.

Objective
This work aimed to examine whether sNFL mediates associations of DM with all-cause mortality and the extent of interaction or joint relations of sNFL and DM with mortality.

Methods
This population-based cohort study was conducted using the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey. A total of 2071 adults aged 20 to 75 years with sNFL measurements were included. sNFL was lg-transformed (LgNfl). Participants were included whose LgNfl was higher than 1.48 pg/mL or who were diagnosed with DM. All-cause mortality was the primary outcome obtained through linkage to registries.

Results
During a median follow-up of 6.1years, 85 participants died. Incidence rates (per 1000 person-years [95% CI]) of all-cause mortality were 27.78 (19.98∼35.58) in adults with LgNfl greater than 1.48 pg/mL and DM, 9.01 (1.99∼16.03) in adults with LgNfl greater than 1.48 pg/mL but no DM, 3.07 (1.01∼5.13) in adults with DM and LgNfl less than or equal to 1.48 pg/mL, and 2.21 (1.15∼3.27) in adults without DM and LgNfl less than or equal to 1.48 pg/mL. Significant interaction but not mediation was observed between LgNfl and DM. Compared with adults without DM and LgNfl less than or equal to 1.48 pg/mL, those with DM and LgNfl greater than 1.48 pg/mL had higher risks of all-cause mortality (hazard ratio; 95% CI, 7.06; 3.52∼14.16).

Conclusion
In general US adults with DM, elevated sNFLs were associated with higher all-cause mortality specifically, supporting an important role of sNFLs in predicting health outcome in individuals with DM.
Continuous Glucose Monitoring Profiles and Health Outcomes After Dapagliflozin Plus Saxagliptin vs Insulin Glargine
Authors: Simonson Donald C , Testa Marcia A , Ekholm Ella , Su Maxwell , Vilsbøll Tina , Jabbour Serge A , Lind Marcus 
Published: February 2024

Abstract

Context
Glycemic variability and hypoglycemia during diabetes treatment may impact therapeutic effectiveness and safety, even when glycated hemoglobin (HbA1c) reduction is comparable between therapies.

Objective
We employed masked continuous glucose monitoring (CGM) during a randomized trial of dapagliflozin plus saxagliptin (DAPA + SAXA) vs insulin glargine (INS) to compare glucose variability and patient-reported outcomes (PROs).

Design
24-week substudy of a randomized, open-label, 2-arm, parallel-group, phase 3b study.

Setting
Multicenter study (112 centers in 11 countries).

Patients
283 adults with type 2 diabetes (T2D) inadequately controlled with metformin ± sulfonylurea.

Interventions
DAPA + SAXA vs INS.

Main outcome measures
Changes in CGM profiles, HbA1c, and PROs.

Results
Changes from baseline in HbA1c with DAPA + SAXA were similar to those observed with INS, with mean difference [95% confidence interval] between decreases of −0.12% [−0.37 to 0.12%], P = .33. CGM analytics were more favorable for DAPA + SAXA, including greater percent time in range (&gt; 3.9 and ≤ 10 mmol/L; 34.3 ± 1.9 vs 28.5 ± 1.9%, P = .033), lower percent time with nocturnal hypoglycemia (area under the curve ≤ 3.9 mmol/L; 0.6 ± 0.5 vs 2.7 ± 0.5%, P = .007), and smaller mean amplitude of glycemic excursions (−0.7 ± 0.1 vs −0.3 ± 0.1 mmol/L, P = .017). Improvements in CGM were associated with greater satisfaction, better body weight image, less weight interference, and improved mental and emotional well-being.

Conclusion
DAPA + SAXA and INS were equally effective in reducing HbA1c at 24 weeks, but people with T2D treated with DAPA + SAXA achieved greater time in range, greater reductions in glycemic excursions and variability, less time with hypoglycemia, and improved patient-reported health outcomes.
Effect of Sevoflurane Anesthesia on Diastolic Function: A Prospective Observational Study
Authors: Lee Sang Hyun , Ahn Hyun Joo , Kim Gyeong Min , Yang MiKyung , Kim Jie Ae , Lee Sangmin M. , Heo Burn Young , Choi Ji Won , Lee Jin Young , Jeong Heejoon , Kim Jeayoun 
Published: February 2024

BACKGROUND:
The effect of sevoflurane on left ventricular diastolic function is not well understood. We hypothesized that parameters of diastolic function may improve under sevoflurane anesthesia in patients with preexisting diastolic dysfunction compared to patients with normal diastolic function.

METHODS:
This observational study included 60 patients undergoing breast surgery or laparoscopic cholecystectomy. Patients were assigned to diastolic dysfunction (n = 34) or normal (n = 26) groups of septal e’ < 8 or ≥ 8.0 cm/s on the first thoracic echocardiography (TTE) performed before anesthesia. During anesthesia, sevoflurane was maintained at 1 to 2 minimum alveolar concentration (MAC) to maintain the bispectral index at 40 to 50. At the end of surgery, the second TTE was performed under 0.8 to 1 MAC of sevoflurane with the patient breathing spontaneously without ventilator support. Primary end point was the percentage change (Δ) of e’ on 2 TTEs (Δe’). Secondary end points were ΔE/e’, Δleft atrial volume index (ΔLAVI), and Δtricuspid regurgitation maximum velocity (ΔTR Vmax). These percentage changes (Δ) were compared between diastolic dysfunction and normal groups.

RESULTS:
e’ (Δe’: 30 [6, 64] vs 0 [−18, 11]%; P < .001), mitral inflow E wave velocity (E), mitral inflow E/A ratio (E/A), and mitral E velocity deceleration time (DT) improved significantly in diastolic dysfunction group compared to normal group. LAVI decreased in diastolic dysfunction group but did not reach statistical significance between the 2 groups (ΔLAVI:−15 [−31, −3] vs −4 [−20, 10]%, P = .091). ΔE/e’ was not different between the 2 groups (11 [−16, 26] vs 12 [−9, 22]%, P = .853) (all: median [interquartile range, IQR]). TR was minimal in both groups.

CONCLUSIONS:
In this study, echocardiographic parameters of diastolic function, including septal e’, E, E/A, and DT, improved with sevoflurane anesthesia in patients with preexisting diastolic dysfunction, but remained unchanged in patients with normal diastolic function.