bluuebunny/crossref_metadata_2025_split huggingface dataset:
System biology approach to delineate expressional difference in the blood mononuclear cells between healthy and Turner syndrome individuals
Authors: Farooqui Anam , Tamkeen Naaila , Tazyeen Safia , Ali Sher , Ishrat Romana 
Published: February 2024

Abstract
Background
Turner syndrome (TS) is a rare disorder associated either with complete or partial loss of one X chromosome in women. The information on the genotype–phenotype relationship in TS is inadequate. Comparing the healthy and Turner syndrome patients may help elucidate the mechanisms involved in TS pathophysiology. Gene expression differences between healthy and individuals with Turner syndrome were characterized using the systems-biology approach of weighted gene coexpression network analysis (WGCNA) on 182 microarray peripheral mononuclear blood samples (PBMC).

Results
The coexpression networks of healthy and TS had scale-free topology that ensures network robustness. In the process, five modules were preserved between healthy and TS, which carry several genes common in each module. Two of them, SMCHD1 and PGK1, have already been reported to be involved in TS. Previously reported genes of TS, specifically, PTPN22, RPS4X, CSF2RA, and TIMP1, were missing in their respective modules. Dysfunction, differential expression, or absence of these genes could lead to a progressive disruption of molecular pathways leading to the pathophysiology of TS. Indeed, we observed a significant difference in the functions of these modules when compared within and across the healthy and TS samples. We identified four clusters in the PPI network constructed from the top 15 KME enriched in significant functions.

Conclusion
Overall, our work highlights the potential molecular functions, pathways, and molecular targets of TS that can be exploited therapeutically in the human healthcare system.
The use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study
Authors: De Rosa Silvia , Ferrari Fiorenza , Greco Massimiliano , Pota Vincenzo , Umbrello Michele , Cotoia Antonella , Pasin Laura , Nalesso Federico , Paternoster Gianluca , Villa Gianluca , Lassola Sergio , Miori Sara , Sanna Andrea , Cantaluppi Vicenzo , Marengo Marita , Valente Fabrizio , Fiorentino Marco , Brunori Giuliano , Bellani Giacomo , Giarratano Antonino 
Published: February 2024

Abstract
Background
Septic shock, a critical condition characterized by organ failure, presents a substantial mortality risk in intensive care units (ICUs), with the 28-day mortality rate possibly reaching 40%. Conventional management of septic shock typically involves the administration of antibiotics, supportive care for organ dysfunction, and, if necessary, surgical intervention to address the source of infection. In recent decades, extracorporeal blood purification therapies (EBPT) have emerged as potential interventions aimed at modulating the inflammatory response and restoring homeostasis in patients with sepsis. Likewise, sequential extracorporeal therapy in sepsis (SETS) interventions offer comprehensive organ support in the setting of multiple organ dysfunction syndrome (MODS). The EROICASS study will assess and describe the utilization of EBPT in patients with septic shock. Additionally, we will evaluate the potential association between EBPT treatment utilization and 90-day mortality in septic shock cases in Italy.

Methods
The EROICASS study is a national, non-interventional, multicenter observational prospective cohort study. All consecutive patients with septic shock at participating centers will be prospectively enrolled, with data collection extending from intensive care unit (ICU) admission to hospital discharge. Variables including patient demographics, clinical parameters, EBPT/SETS utilization, and outcomes will be recorded using a web-based data capture system. Statistical analyses will encompass descriptive statistics, hypothesis testing, multivariable regression models, and survival analysis to elucidate the associations between EBPT/SETS utilization and patient outcomes.

Conclusions
The EROICASS study provides valuable insights into the utilization and outcomes of EBPT and SETS in septic shock management. Through analysis of usage patterns and clinical data, this study aims to guide treatment decisions and enhance patient care. The implications of these findings may impact clinical guidelines, potentially improving survival rates and patient outcomes in septic shock cases.
Experimental and theoretical analysis of finely bedded porous rock models with internal cracks
Authors: da Costa Marcus Danilo F. Borges , de Figueiredo José Jadsom S. , de Lima Celso Rafael , da Silva Daniel N. N. , Aum Pedro T. P. 
Published: February 2024

The behavior of ultrasonic waves in synthetic rocks consisting of alternating layers of sand-based (porous and permeable) and acrylic (unporous) materials is investigated. Two synthetic layered media are created, one without cracks and the other with parallel cracks in one of the layers, to increase anisotropy and simulate a heterogeneous transversely isotropic medium with a vertical axis of symmetry. Microcomputed tomography is used to obtain images of the samples, which indicate that there are no bubbles present and that the layers are well connected without any gaps or breaks. The experiment uses ultrasonic measurements to determine the propagation of P and S waves, with transducers at frequencies of 100 kHz, 500 kHz, and 1 MHz for traveltime and waveform measurements. These three sources are chosen to verify the effective behavior of the samples, which depends on the relationship between the dominant wavelength of investigation and the layer thickness ([Formula: see text]). The measured velocities are compared with theoretical models based on Backus, Kennett (traditional models), and Backus (modified for cracked media by Schoenberg and Muir’s theory). The main finding is that the cracked medium exhibits at least twice as large a difference in behavior for P- and S-wave vertical velocities as a function of the number of layers compared with the uncracked medium.
Induced polarization of clay-rich materials — Part 3: Partially saturated mixtures of clay and pyrite
Authors: Revil André , Ghorbani Ahmad , Su Zhaoyang , Cai Hongzhu , Hu Xiangyun 
Published: February 2024

Source rocks for oil and gas are often associated with shales that are rich in pyrite and kerogen. Induced polarization is a suitable tool to characterize these formations. We develop a new experimental database of 43 laboratory experiments using mixtures of clay and pyrite under fully or partially water-saturated conditions. The liquid water saturation is in the range of 20%–100%, whereas the pyrite content is in the range of 0%–17%. Spectral-induced polarization measurements are performed in the frequency range of 0.1 Hz to 45 kHz at room temperature (approximately 25°C ± 1°C). The complex conductivity spectra are fitted with a Cole-Cole model, and the Cole-Cole parameters are determined using a stochastic procedure based on a Markov chain Monte Carlo sampler. The Cole-Cole parameters associated with low-frequency dispersion are then plotted as a function of the (water) saturation and pyrite content (volume fractions). Four predictions of the model are tested against the experimental data. We find that the model is able to explain the results, including (1) the chargeability depends on the pyrite content in a predictable way, (2) the (instantaneous) conductivity depends on the saturation according to Archie’s law, (3) the Cole-Cole exponent does not depend on the saturation and pyrite content (except at very small pyrite content of <1 vol%), and (4) the relaxation time is inversely proportional to the instantaneous conductivity. We also develop a more advanced petrophysical model using a double Cole-Cole distribution, in which one distribution is associated with the clay minerals and the other is associated with the pyrite.
Practice Consolidation Among US Medical Oncologists, 2015-2022
Authors: Milligan Michael , Erfani Parsa , Orav E. John , Schleicher Stephen , Brooks Gabriel A. , Lam Miranda B. 
Published: February 2024

PURPOSE Health care consolidation has significantly affected cancer care delivery, with oncology practices undergoing substantial consolidation over the past two decades. This study investigates practice consolidation trends among medical oncologists (MOs), factors associated with consolidation, and changes in MO geographic distribution. METHODS Medicare data from 2015 to 2022 were used to assess MO practice consolidation in hospital referral regions (HRRs), linked with regional health care market data and physician demographics. The Herfindahl-Hirschman Index (HHI) was used to measure consolidation, and the Gini coefficient was used to measure MO distribution across counties. Multivariable linear regression explored factors associated with MO practice consolidation. RESULTS Between 2015 and 2022, the number of MOs increased by 14.5% (11,727-13,433), whereas the number of MO practices decreased by 18.0% (2,774-2,276). The mean number of MOs per practice increased by 40% (4.26-5.95; P < .001). The percentage of MOs in small practices decreased, whereas larger practices saw an increase. MO consolidation, as indicated by the HHI, increased by 9% (median HHI, 0.3204-0.3480). HRRs with higher baseline hospital consolidation and more hospital beds per capita were more likely to have MO practice consolidation. Despite MO practice consolidation, the county-level distribution of MOs did not change substantially. CONCLUSION On the basis of Federal Trade Commission classifications, MO practices were highly concentrated in 2015 and consolidated even further by 2022. While distribution of MOs at the county level remained stable, further research is needed to assess the effects of rapid consolidation on cancer care cost, quality, and access. These data have important implications for policymakers and payers as they design programs that ensure high-quality, affordable cancer care.
An Integrated Predictive Maintenance and Operations Scheduling Framework for Power Systems Under Failure Uncertainty
Authors: Okumuşoğlu Bahar Cennet , Basciftci Beste , Kocuk Burak 
Published: February 2024

Maintenance planning plays a key role in power system operations under uncertainty as it helps providers and operators ensure a reliable and secure power grid. This paper studies a short-term condition-based integrated maintenance planning with operations scheduling problem while considering the possible unexpected failure of generators as well as transmission lines. We formulate this problem as a two-stage stochastic mixed-integer program with failure scenarios sampled from the sensor-driven remaining lifetime distributions of the individual system elements whereas a joint chance constraint consisting of Poisson Binomial random variables is introduced to account for failure risks. Because of its intractability, we develop a cutting-plane method to obtain an exact reformulation of the joint chance constraint by proposing a separation subroutine and deriving stronger cuts as part of this procedure. We also derive a second-order cone programming-based safe approximation of this constraint to solve large-scale instances. Furthermore, we propose a decomposition algorithm implemented in parallel fashion for solving the resulting stochastic program, which exploits the features of the integer L-shaped method and the special structure of the maintenance and operations scheduling problem to derive valid and stronger sets of optimality cuts. We further present preprocessing steps over transmission line flow constraints to identify redundancies. To illustrate the computational performance and efficiency of our algorithm compared with more conventional maintenance approaches, we design a computational study focusing on a weekly plan with daily maintenance and hourly operational decisions involving detailed unit commitment subproblems. Our computational results on various IEEE instances demonstrate the computational efficiency of the proposed approach with reliable and cost-effective maintenance and operational schedules. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.0154 .
Real-Time Derivative Pricing and Hedging with Consistent Metamodels
Authors: Jiang Guangxin , Hong L. Jeff , Shen Haihui 
Published: February 2024

In derivative pricing and hedging, the consistency between the price and Greek surfaces (i.e., the Greek surfaces can be obtained by differentiating the price surface) is important in stabilizing the balance sheet and reducing the hedging cost. To build consistent surfaces of the price and Greeks for real-time decisions, we propose to use the gradient-enhanced stochastic kriging method, based on the data collected through extensive simulation experiments conducted when the market is closed. In addition to the naturally guaranteed consistency, we prove that the constructed price and Greek surfaces are more accurate than those constructed separately using stochastic kriging. Besides the consistency between the price and Greeks, we show that the partial differential equation relation between the price and Greeks, implied by the famous Feynman-Kac formula, can also be used to further improve the accuracy of the constructed surfaces. The numerical studies show that our proposed metamodeling methods work well for derivative pricing and hedging. History: Accepted by Bruno Tuffin, Area Editor for Simulation. Funding: This work was supported by the National Natural Science Foundation of China [Grants 72161160340, 72293562, 72121001, 72031006, and 72171060]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0292 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0292 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Competition of Memories? The Memory of the Łódź/Litzmannstadt Ghetto in Contemporary Museums in Łódź
Authors: Taczyńska Katarzyna 
Published: February 2024

Abstract
There is no individual museum dedicated to the Łódź Ghetto in which 200,000 Jews were confined. However, there are institutions actively working to preserve the memory of the Jewish community in Łódź. This article focuses on two recently established museums in the city: the Radegast Station, founded in 2009, and the Museum of Polish Children, established in 2021. The aim is to analyze the mechanisms that led to the creation of these historical museums and explore their specific functions. I am interested not only in how these institutions shape and present the Jewish heritage, but also in the conceptualisation of the social role of these institutions and the analysis of their presence in the public space. To achieve this, I examine local micro-interactions within the current framework of Poland’s politics of history. Given that nationalism is the predominant ideology of modernity, my text demonstrates how nationalist discourses impact the commemoration of the Łódź/Litzmannstadt Ghetto and influence the remembrance of Second World War.
The effect of GnRH analog treatment on BMI in children treated for precocious puberty: a systematic review and meta-analysis
Authors: Zhu Xiaoxiao , Qin Jiajia , Xue Weirong , Li Shengli , Zhao Meng , Yingliang Jin  
Published: February 2024

Abstract

Introduction
The purpose of the present meta-analysis was to systematically evaluate the effect of GnRHa treatment on the BMI of children with precocious puberty after GnRHa treatment as compared to before, and to analyze the effect of GnRHa treatment on the body composition of children with precocious puberty at different BMIs by classifying into normal body mass, overweight, and obese groups according to BMI at the time of initial diagnosis.

Content
A meta-analysis was performed using Stata 12.0 software by searching PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP database), and Wan fang database for relevant literature on standard deviation score of body mass index (BMI-SDS) after GnRHa treatment as compared to before in children with precocious puberty.

Summary
A total of eight studies were included with a total sample size of 715 cases, and the results of meta-analysis showed that BMI-SDS increased in children with precocious puberty after GnRHa treatment as compared to before starting [(weighted mean difference (WMD)=0.23, 95 % CI: 0.14–0.33, p=0.000)] and also increased in children with normal body mass [(WMD=0.37, 95 % CI: 0.28–0.46, p=0.000)], and there was no significant change in BMI-SDS in children in the overweight or obese group [(WMD=0.01, 95 % CI: −0.08–0.10, p=0.775)].

Outlook
Overall, there was an observed increase in BMI-SDS at the conclusion of GnRHa treatment in children with precocious puberty. Additionally, it was found that the effect of GnRHa treatment on body composition varied among children with different BMI status. Clinicians should emphasize the promotion of a healthy lifestyle and personalized dietary management for children.
Prácticas Educativas Familiares en el contexto rural de la educación inicial colombiana
Authors: Osorio Arrieta Yan 
Published: February 2024

La relación entre la familia y la escuela en contextos rurales está profundamente influenciada por las características únicas de estas comunidades, incluyendo la proximidad geográfica, los vínculos comunitarios, las tradiciones arraigadas y la economía local. Esta relación única puede ser aprovechada para enriquecer la experiencia educativa de los estudiantes y fortalecer los lazos entre la escuela, la familia y la comunidad. De modo que, este artículo científico tiene el propósito de reconocer los elementos centrales del apoyo familiar en el entorno rural y su impacto en el desempeño académico y la convivencia de los estudiantes del nivel de educación inicial. Por ello, se emplea una metodología cualitativa fundamentada en un diseño participativo, mediado por las técnicas de observación participante y análisis de contenido que, se erigen como una valiosa alternativa para comprender las interacciones entre los padres y la escuela, identificar los factores que las condicionan o influyen, abordar la falta de apoyo parental hacia la educación de sus hijos, caracterizar las familias y su entorno sociocultural, definir elementos centrales de la experiencia mediante una línea temporal y el análisis de los saberes emergentes del proceso de apoyo familiar, así como sus contribuciones a una convivencia escolar saludable. En los resultados, se presenta la sistematización de la experiencia educativa que impulsa la creación y el discernimiento crítico de aquellos que participan en ella, concluyendo en la importancia de dar continuidad y fortalecer las relaciones entre los tres pilares esenciales: madres/padres, estudiantes y docentes-escuela, subrayando la necesidad de continuar y reforzar estas interacciones para un desarrollo educativo más completo.
Investigation of the relationship between cervical disc herniations and shoulder complex pathologies
Authors: TUNCER Cengiz , KILIÇ Rabia Tuğba , KILIÇ Güven , KARADUMAN Zekeriya Okan , ARICAN Mehmet , AKBARİ Pouriya , ULUDAĞ Veysel 
Published: February 2024

Objective: The aim of our study was to investigate whether there is a relationship between shoulder complex pathologies and cervical disc herniations.
Methods: This study retrospectively included 524 patients with both dominant extremity shoulder and neck magnetic resonance examinations obtained from the information processing unit of Düzce University Faculty of Medicine between 01.08.2009-01.08.2023. The results were compared in Statistical Package for Social Sciences (SPSS).
Results: A total of 524 patients, 153 (29.2%) males and 371 (70.8%) females, with a mean age of 51.17±13.70 (range, 13-93) years, were included in the study.According to the statistical analysis of our study, 410 of the participants had supraspinatus pathology, 234 had infraspinatus pathology, 243 had subscapularis pathology and 11 had teres minor pathology. In addition, a statistically significant relationship was found between other shoulder pathologies and herniations at the C4-C5 and C5-C6 disc level (p
SNOWBALL-THROWING METHOD EDUCATION INCREASES THE KNOWLEDGE AND ATTITUDES OF ADOLESCENTS ABOUT THE MATURATION OF MARRIAGE AGE (PUP)
Authors: Narmin Narmin , Amsal Amsal , Admasari Yuli , Amalia Munifa 
Published: February 2024

Background: Maturation of Marital Age is an effort to raise the age of child marriage. The number of underage marriages results in rapid population development, high maternal and infant mortality rates, low maternal and child health, families are often not harmonious, domestic violence occurs, and is prone to divorce. The rate of child marriage in Central Sulawesi is very high, one of which is in Donggala district. Donggala Regency ranks 3rd with 196 child marriages in 2022. A contributing factor is the lack of knowledge and attitudes of adolescents about maturing marriage age. The purpose of the study was to determine the effect of snowball throwing method counseling on the management and attitudes of adolescents about the maturation of marriage age at SMKS Al-Amin Wani Method: The pre-experimental research with one group pretest-posttest design was conducted from April 14 to May 20, 2023, at SMKS Al-Amin Wani. Proportional stratified random sampling technique of 75 respondents. Analyzes data through the Wilcoxon test. Result: 31 respondents (41.3%) is 16 years old, 55 respondents (73.3%) is female. the most dominant knowledge was in a good category, 75 respondents (100%). Average increase in knowledge and attitude score of 38.00 and p-value of 0.000. Conclusion: Education on snowball throwing method can improve teenagers' knowledge and attitudes about marriage-age maturity at SMKS Al-Amin Wani.
THE RELATIONSHIP BETWEEN EXCLUSIVE BREASTFEEDING AND THE INCIDENCE OF STUNTED GROWTH IN INFANTS IN THE VILLAGE OF TALANGKUSKO, TUREN DISTRICT, MALANG
Authors: Fahrina Riza Arsanty , Amalia Rize Budi 
Published: February 2024

Background: Stunted is a chronic malnutrition problem caused by malnutrition in the first 1,000 days of life. One of the risk factors for stunted growth is suboptimal exclusive breastfeeding. This study aimed to determine the relationship between exclusive breastfeeding and stunted growth incidence in infants in Talangsuko Village, Turen District, Malang. Methods: This study used an analytical observational research design with a cross-sectional approach. The research sample was 118 respondents of mothers with infants aged 6-24 months in Talangsuko Village, Turen District, Malang. The measured variables are stunted status and exclusive breastfeeding. Data was collected through questionnaires and height measurements. The research data was processed using SPSS with Chi-square analysis. Results: The results showed that 16 (13,6%) child stunted, 73 respondents (61.9%) received exclusive breastfeeding, while 45 respondents (38.1%) did not receive exclusive breastfeeding. The results of the chi-square test showed that there was a significant relationship between exclusive breastfeeding and stunted growth incidence (p=0,000). Conclusion: The conclusion of this study is that there is a significant relationship between exclusive breastfeeding and stunted growth incidence in infants in Talangsuko Village, Turen District, Malang. Therefore, exclusive breastfeeding is one of the important efforts to prevent stunted growth in infants.