bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial landmark detection and tissue registration with deep learning
Authors: Ekvall Markus , Bergenstråhle Ludvig , Andersson Alma , Czarnewski Paulo , Olegård Johannes , Käll Lukas , Lundeberg Joakim 
Published: March 2024

AbstractSpatial landmarks are crucial in describing histological features between samples or sites, tracking regions of interest in microscopy, and registering tissue samples within a common coordinate framework. Although other studies have explored unsupervised landmark detection, existing methods are not well-suited for histological image data as they often require a large number of images to converge, are unable to handle nonlinear deformations between tissue sections and are ineffective for z-stack alignment, other modalities beyond image data or multimodal data. We address these challenges by introducing effortless landmark detection, a new unsupervised landmark detection and registration method using neural-network-guided thin-plate splines. Our proposed method is evaluated on a diverse range of datasets including histology and spatially resolved transcriptomics, demonstrating superior performance in both accuracy and stability compared to existing approaches.
Fixed-time angle of attack constrained control for aircraft considering dynamic icing process
Authors: Dong Zehong , Da Xingya , Li Yinghui , Li Zhe , Xie Like 
Published: March 2024

AbstractAircraft icing deteriorates aerodynamic performance and reduces stall angle of attack, the fast convergence rate of tracking error is required to stabilize the aircraft when aircraft icing occurs. The state-of-the-art control methods for icing aircraft mostly assume that the icing of aircraft is instantaneous. Aiming at these issues, a fixed-time angle of attack-constrained control strategy is designed considering dynamic icing process. In order to explore the variation of aerodynamic coefficients in the process of dynamic icing, an ice wind tunnel experiment is implemented, and the relationship between lift coefficient, drag coefficient and pitching moment coefficient with angle of attack and icing intensity is obtained by fitting method. In order to prevent the stalling problem caused by the decrease of the stalling angle of attack in the process of dynamic icing, a method to determine the stalling angle of attack based on deep neural network is proposed. Considering the asymmetric and time-varying angle of attack constraint, a fixed-time convergent angle of attack-constrained robust control method is designed. The ice wind tunnel experiment shows the process of dynamic icing of the airfoil, and the simulation results verify the effectiveness of the proposed control method.
Non-KAM classical chaos topology for electrons in superlattice minibands determines the inter-well quantum transition rates
Authors: Wang F. , Greenaway M. T. , Balanov A. G. , Fromhold T. M. 
Published: March 2024

AbstractWe investigate the quantum-classical correspondence for a particle tunnelling through a periodic superlattice structure with an applied bias voltage and an additional tilted harmonic oscillator potential. We show that the quantum mechanical tunnelling rate between neighbouring quantum wells of the superlattice is determined by the topology of the phase trajectories of the analogous classical system. This result also enables us to estimate, with high accuracy, the tunnelling rate between two spatially displaced simple harmonic oscillator states using a classical model, and thus gain new insight into this generic quantum phenomenon. This finding opens new directions for exploring and understanding the quantum-classical correspondence principle and quantum jumps between displaced harmonic oscillators, which are important in many branches of natural science.
The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds
Authors: Schobel Seth A. , Gann Eric R. , Unselt Desiree , Grey Scott F. , Lisboa Felipe A. , Upadhyay Meenu M. , Rouse Michael , Tallowin Simon , Be Nicholas A. , Zhang Xijun , Dalgard Clifton L. , Wilkerson Matthew D. , Hauskrecht Milos , Badylak Stephen F. , Zamora Ruben , Vodovotz Yoram , Potter Benjamin K. , Davis Thomas A. , Elster Eric A. 
Published: March 2024

AbstractA combination of improved body armor, medical transportation, and treatment has led to the increased survival of warfighters from combat extremity injuries predominantly caused by blasts in modern conflicts. Despite advances, a high rate of complications such as wound infections, wound failure, amputations, and a decreased quality of life exist. To study the molecular underpinnings of wound failure, wound tissue biopsies from combat extremity injuries had RNA extracted and sequenced. Wounds were classified by colonization (colonized vs. non-colonized) and outcome (healed vs. failed) status. Differences in gene expression were investigated between timepoints at a gene level, and longitudinally by multi-gene networks, inferred proportions of immune cells, and expression of healing-related functions. Differences between wound outcomes in colonized wounds were more apparent than in non-colonized wounds. Colonized/healed wounds appeared able to mount an adaptive immune response to infection and progress beyond the inflammatory stage of healing, while colonized/failed wounds did not. Although, both colonized and non-colonized failed wounds showed increasing inferred immune and inflammatory programs, non-colonized/failed wounds progressed beyond the inflammatory stage, suggesting different mechanisms of failure dependent on colonization status. Overall, these data reveal gene expression profile differences in healing wounds that may be utilized to improve clinical treatment paradigms.
Assessment of parental mosaicism rates in neurodevelopmental disorders caused by apparent de novo pathogenic variants using deep sequencing
Authors: Lecoquierre François , Cassinari Kévin , Drouot Nathalie , May Angèle , Fourneaux Steeve , Charbonnier Francoise , Derambure Celine , Coutant Sophie , Saugier-Veber Pascale , Hoischen Alexander , Charbonnier Camille , Nicolas Gaël 
Published: March 2024

AbstractWhile de novo variants (DNV) are overall at low risk of recurrence in subsequent pregnancies, a subset is at high risk due to parental mosaicism. Accurately identifying cases of parental mosaicism is therefore important for genetic counseling in clinical care. Some studies have investigated the rate of parental mosaics, but most were either limited by the sensitivity of the techniques (i.e. exome or genome sequencing), or focused on specific types of disease such as epileptic syndromes. This study aimed to determine the proportion of parental mosaicism among the DNV causing neurodevelopmental disorders (NDDs) in a series not enriched in epilepsy syndromes. We collected 189 patients with NDD-associated DNV. We applied a smMIP enrichment method and sequenced parental blood DNA samples to an average depth of 7000x. Power simulation indicated that mosaicism with an allelic fraction of 0.5% would have been detected for 87% of positions with 90% power. We observed seven parental mosaic variants (3.7% of families), of which four (2.1% of families) had an allelic fraction of less than 1%. In total, our study identifies a relatively low proportion of parental mosaicism in NDD-associated DNVs and raises the question of a biological mechanism behind the higher rates of parental mosaicism detected in other studies, particularly those focusing on epileptic syndromes.
Experimental study on the quasi-static and dynamic tensile behaviour of thermally treated Barakar sandstone in Jharia coal mine fire region, India
Authors: Tripathi Adarsh , Khan Mohammad Mohsin , Pain Anindya , Rai Nachiketa , Iqbal Mohd Ashraf 
Published: March 2024

AbstractIn the present study, the effect of mild to high-temperature regimes on the quasi-static and dynamic tensile behaviours of Barakar sandstone from the Jharia coal mine fire region has been experimentally investigated. The experimental work has been performed on Brazilian disk specimens of Barakar sandstone, which are thermally treated up to 800 °C. The quasi-static and dynamic split tensile strength tests were carried out on a servo-controlled universal testing machine and Split Hopkinson Pressure Bar (SHPB), respectively. Microscopic and mineralogical changes were studied through a petrographic investigation. The experimental results suggest the prevalence of both, static and dynamic loading scenarios after 400 °C. Up to 400 °C, the quasi-static and dynamic tensile strengths increased due to the evaporation of water, which suggests a strengthening effect. However, beyond 400 °C, both strengths decreased significantly as newly formed thermal microcracks became prevalent. The dynamic tensile strength exhibits strain rate sensitivity up to 400 °C, although it shows a marginal decline in this sensitivity beyond this temperature threshold. The Dynamic Increase Factor (DIF) remained constant up to 400 °C and slightly increased after 400 °C. Furthermore, the characteristic strain rate at which the dynamic strength becomes twice the quasi-static strength remains consistent until reaching 400 °C but steadily decreases beyond this temperature. This experimental study represents the first attempt to validate the Kimberley model specifically for thermally treated rocks. Interestingly, the presence of water did not have a significant impact on the failure modes up to 400 °C, as the samples exhibited a dominant tensile failure mode, breaking into two halves with fewer fragments. However, as temperature increased, the failure behaviours became more complex due to the combined influence of thermally induced microcracks and the applied impact load. Cracks initially formed at the centre and subsequently, multiple shear cracks emerged and propagated in the loading direction, resulting in a high degree of fragmentation. This study also demonstrates that shear failure is not solely dependent on the loading rate but can also be influenced by temperature, further affecting the failure mode of the sandstone.
Retinal hemorrhages and damages from tractional forces associated with infantile abusive head trauma evaluated by wide-field fundus photography
Authors: Azuma Noriyuki , Yoshida Tomoyo , Yokoi Tadashi , Nishina Sachiko , Uematsu Satoko , Miyasaka Mikiko 
Published: March 2024

AbstractWe evaluated the distribution and types of retinal hemorrhages (RHs) and other damages in eyes with abusive head trauma (AHT). This retrospective, consecutive case series of AHT and non-AHT conditions involved 54 children with AHT, 43 children with head bruises, and 49 children with blunt eye trauma, each of non-AHT supported by reliable witness accounts. RHs and other damage were evaluated using ophthalmoscopy and wide-field fundus photography. A variety of RH types and other damage were identified in the AHT group but not in the non-AHT group. RHs in AHT extended from the posterior pole to the far periphery in 77% of eyes and on/near the veins in 86% and arteries in 85%, most of which were in the far periphery. Retinoschisis, white-dot lesions, and retinal folds were seen even in the far periphery. RHs on/near the veins and arteries, retinoschisis, and retinal folds suggest a traumatic mechanism of the tractional force of the vitreous that is attached to the entire retinal surface. Identifying the distribution and arterio and venous origins of RHs is a key factor in determining the association with trauma. Thus, wide-field fundus photography is useful to record and evaluate the origin of the RHs and other retinal damage.
Investigation of color and physicomechanical properties of peek and pekk after storage in a different medium
Authors: Kaya Nihan , Sasany Rafat , Yanıkoglu Nuran , Tosun Busra 
Published: March 2024

AbstractThe aim of this study is to assess color stability, solubility, and water sorption on polyether ether ketone (PEEK) and polyether ketone ketone (PEKK) after immersion in different storage conditions. Material and Methods Ninety disc-shaped specimens (8 × 2) were obtained from CAD/CAM blocks [PEEK (n = 45) and PEKK (n = 45)]. Before immersion, baseline color value data were recorded with a spectrophotometer. The specimens were soaked in three solutions red wine, coffee, and distilled water at 37 °C for 28 days. Following immersion, color values were remeasured, and color-change values (ΔE) were calculated. Water sorption and solubility were assessed by mass gain or loss after storage in water for 28 days. The Kruskal–Wallis and the Mann–Whitney U test were used for analysis (P = 0.05). Results ΔE00 between PEEK and PEKK was significantly different statistically (P < 0.001). PEEK presented higher water sorption than PEKK (P = 0.005). The difference in solubility between PEEK and PEKK was not statistically significant (P = 0.163). The materials and storage medium types had a statistically significant impact (P = 0.100). In terms of staining potential, the solutions tested in this experiment were ranked as: coffee > red wine > distilled water. The results of this study demonstrated that PEKK was more successful in polymer-containing CAD/CAM materials as it exhibited less color change and water absorption.
High methane ebullition throughout one year in a regulated central European stream
Authors: Michaelis Tamara , Kaplar Felicitas , Baumann Thomas , Wunderlich Anja , Einsiedl Florian 
Published: March 2024

AbstractEbullition transports large amounts of the potent greenhouse gas methane (CH$$_4$$

4

) from aquatic sediments to the atmosphere. River beds are a main source of biogenic CH$$_4$$

4

, but emission estimates and the relative contribution of ebullition as a transport pathway are poorly constrained. This study meets a need for more direct measurements with a whole-year data set on CH$$_4$$

4

ebullition from a small stream in southern Germany. Four gas traps were installed in a cross section in a river bend, representing different bed substrates between undercut and slip-off slope. For a comparison, diffusive fluxes were estimated from concentration gradients in the sediment and from measurements of dissolved CH$$_4$$

4

in the surface water. The data revealed highest activity with gas fluxes above 1000 ml m$$^{-2}$$

-
2

d$$^{-1}$$

-
1

in the center of the stream, sustained ebullition during winter, and a larger contribution of ebullitive compared to diffusive CH$$_4$$

4

fluxes. Increased gas fluxes from the center of the river may be connected to greater exchange with the surface water, thus increased carbon and nutrient supply, and a higher sediment permeability for gas bubbles. By using stable isotope fractionation, we estimated that 12-44% of the CH$$_4$$

4

transported diffusively was oxidized. Predictors like temperature, air pressure drop, discharge, or precipitation could not or only poorly explain temporal variations of ebullitive CH$$_4$$

4

fluxes.
Obstetric and neonatal outcomes in pregnant women with idiopathic polyhydramnios: a systematic review and meta-analysis
Authors: Kechagias Konstantinos S. , Triantafyllidis Konstantinos Katsikas , Zouridaki Georgia , Savvidou Makrina 
Published: March 2024

AbstractAlthough the assessment of the amniotic fluid volume in pregnancy is part of the fetal wellbeing surveillance, the impact of idiopathic polyhydramnios (IP) on maternal and perinatal outcomes in unknown. The aim of this meta-analysis was to investigate the association of IP with different maternal and perinatal outcomes. We screened five electronic databases until December 2023 and performed data extraction and quality assessment using ROBINS-E in duplicates. Pooled risk ratios and 95% confidence intervals (95% CI) were calculated with a random effects model. 38 studies were included. Patients with IP were at increased risk of perinatal complications including preterm delivery (RR 1.96, 95% CI 1.35–2.86; I2 = 92%), placental abruption (RR 3.20, 95% CI 2.20–4.65; I2 = 2%), delivery via caesarean section (RR 1.60, 95% CI 1.39–1.84; I2 = 95%) and postpartum haemorrhage (RR 1.98, 95% CI 1.22–3.22; I2 = 84%). Similarly, IP was associated with increased risk of adverse perinatal outcomes including low APGAR score (RR 3.0, 95% CI 1.23–7.35; I2 = 95%), stillbirth (RR 4.75, 95% CI 2.54–8.86; I2 = 9%) and perinatal mortality (RR 4.75, 95% CI 2.67–8.48; I2 = 37%). This meta-analysis suggests that pregnant women with IP may be at increased risk of perinatal complications and adverse neonatal outcomes. However, data remains inconclusive considering the low quality and high heterogeneity of included studies.PROSPERO registration number: CRD42022359944.
Investigating the efficacy and importance of mobile-based assessments for Parkinson's disease: uncovering the potential of novel digital tests
Authors: Zhang Yanci , Zeng Zhiwei , Mirian Maryam S. , Yen Kevin , Park Kye Won , Doo Michelle , Ji Jun , Shen Zhiqi , McKeown Martin J. 
Published: March 2024

AbstractThis study introduces PDMotion, a mobile application comprising 11 digital tests, including those adapted from the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III and novel assessments, for remote Parkinson's Disease (PD) motor symptoms evaluation. Employing machine learning techniques on data from 50 PD patients and 29 healthy controls, PDMotion achieves accuracies of 0.878 for PD status prediction and 0.715 for severity assessment. A post-hoc explanation model is employed to assess the importance of features and tasks in diagnosis and severity evaluation. Notably, novel tasks that are not adapted from MDS-UPDRS Part III like the circle drawing, coordination test, and alternative tapping test are found to be highly important, suggesting digital assessments for PD can go beyond digitizing existing tests. The alternative tapping test emerges as the most significant task. Using its features alone achieves prediction accuracies comparable to the full task set, underscoring its potential as an independent screening tool. This study addresses a notable research gap by digitalizing a wide array of tests, including novel ones, and conducting a comparative analysis of their feature and task importance. These insights provide guidance for task selection and future development in PD mobile assessments, a field previously lacking such comparative studies.
Hierarchical channel morphology in O-rings after two cycling exposures to 70 MPa hydrogen gas: a case study of sealing failure
Authors: Lee Chang Hoon , Jung Jae Kap , Kim Kyung Sook , Kim Chang Jong 
Published: March 2024

AbstractThis study investigates the impact of high-pressure hydrogen gas exposure on the structural and morphological characteristics of O-ring materials. O-ring specimens undergo two cycles of sealing under 70 MPa hydrogen gas, and their resulting variations are examined using advanced characterization techniques, including powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), scanning electron microscopy (SEM) and atomic force microscopy (AFM). Our findings reveal that the lattice parameters of the O-ring material show no significant changes when exposed to 70 MPa hydrogen gas. However, in the micrometre range, the formation of a hierarchical channel morphology becomes evident. This morphology is accompanied by the separation of carbon black filler from the rubber matrix, contributing to mechanical weakening of the O-ring. These observations can be attributed to the pressure gradient that develops between the inner and outer radii of the O-ring, resulting from compression forces acting perpendicularly to the radial direction due to clamp locking.
Reconstructing colonization dynamics to establish how human activities transformed island biodiversity
Authors: Tomlinson Sean , Lomolino Mark V. , Anderson Atholl , Austin Jeremy J. , Brown Stuart C. , Haythorne Sean , Perry George L. W. , Wilmshurst Janet M. , Wood Jamie R. , Fordham Damien A. 
Published: March 2024

AbstractDrivers and dynamics of initial human migrations across individual islands and archipelagos are poorly understood, hampering assessments of subsequent modification of island biodiversity. We developed and tested a new statistical-simulation approach for reconstructing the pattern and pace of human migration across islands at high spatiotemporal resolutions. Using Polynesian colonisation of New Zealand as an example, we show that process-explicit models, informed by archaeological records and spatiotemporal reconstructions of past climates and environments, can provide new and important insights into the patterns and mechanisms of arrival and establishment of people on islands. We find that colonisation of New Zealand required there to have been a single founding population of approximately 500 people, arriving between 1233 and 1257 AD, settling multiple areas, and expanding rapidly over both North and South Islands. These verified spatiotemporal reconstructions of colonisation dynamics provide new opportunities to explore more extensively the potential ecological impacts of human colonisation on New Zealand’s native biota and ecosystems.
Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3
Authors: Lee Sumin , Ye Qianying , Yang Hyeyun , Lee Sojung , Kim YeJi , Lee Nahyun , Gonzalez-Cox Darwin , Yi Dong-Keun , Kim Soo-Yong , Choi Sangho , Choi Taesoo , Kim Man S. , Hong Seong Su , Choi Chun Whan , Lee Yoonsung , Park Yong Hwan 
Published: March 2024

AbstractInflammation is implicated as a cause in many diseases. Most of the anti-inflammatory agents in use are synthetic and there is an unmet need for natural substance-derived anti-inflammatory agents with minimal side effects. Aiouea padiformis belongs to the Lauraceae family and is primarily found in tropical regions. While some members of the Aiouea genus are known to possess anti-inflammatory properties, the anti-inflammatory properties of Aiouea padiformis extract (AP) have not been investigated. In this study, we aimed to examine the anti-inflammatory function of AP through the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and elucidate the underlying mechanisms. Treatment with AP inhibited the secretion of interleukin-1 beta (IL-1β) mediated by NLRP3 inflammasome in J774A.1 and THP-1 cells without affecting the viability. In addition, AP treatment did not influence NF-κB signaling, potassium efflux, or intracellular reactive oxygen species (ROS) production—all of which are associated with NLRP3 inflammasome activation. However, intriguingly, AP treatment significantly reduced the ATPase activity of NLRP3, leading to the inhibition of ASC oligomerization and speck formation. Consistent with cellular experiments, the anti-inflammatory property of AP in vivo was also evaluated using an LPS-induced inflammation model in zebrafish, demonstrating that AP hinders NLRP3 inflammasome activation.