bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlates of Psychological Well-Being Among First-Year Medical Students: An Exploratory Study
Authors: Nebhinani Naresh , Nebhinani Mamta R. , Modi Shruti , Rajpurohit Surendra S. , Soni Puneet K. 
Published: April 2024

ABSTRACT

Background and Objectives:
The literature is limited on correlates of psychological well-being among Indian medical undergraduates. The study aimed to assess the psychological well-being, life satisfaction, self-efficacy, positive state of mind, and emotions among first-year medical undergraduates.

Materials and Methods:
It was a cross-sectional study assessing 121 first-year medical undergraduate students. Psychological well-being scale, satisfaction with life scale, general self-efficacy scale, positive state of mind scale, and positive and negative affect schedule revised version were used.

Results:
The majority of medical undergraduate students were satisfied with the life. Their life satisfaction was positively associated with general self-efficacy, positive state of mind, and positive affect score. These indicators were negatively associated with negative affect score. Male students had significantly greater self-efficacy.

Conclusion:
Medical students’ life satisfaction was found to be positively associated with other wellness indicators. Resilience-based positive psychology interventions should be implemented in medical colleges to enhance psychological well-being.
Prehypertension and Hypertension among School Teachers: An Epidemiological Study from South India
Authors: DevivaraPrasad M. , Subramaniyan P. , Praveen Kumar B. A. , Janakiraman P. 
Published: April 2024

ABSTRACT

Context:
Teaching is regarded as one of the most stressful occupations, making them more vulnerable to cardiovascular diseases, especially hypertension.

Aims and Objectives:
We explored this study to estimate the prevalence of pre-hypertension and hypertension and its risk factors among school teachers.

Settings and Design:
This cross-sectional study was conducted for one year among 400 school teachers working in primary and secondary schools in southern Andhra Pradesh.

Materials and Methods:
Cluster sampling technique was used for sampling, where each school was considered as a cluster. A validated proforma with a questionnaire developed based on the WHO STEPS manual was used to collect data on socio-demographic details, blood pressure recordings, anthropometric measurements, and other related factors.

Statistical Analysis:
Odds ratio, the Chi-square test, and regression analysis was used to test the significance, where p < 0.05 was considered significant.

Results:
Among 400 subjects, 52.3% had normal blood pressure, 32.0% had pre-hypertension, and 15.7% had hypertension, with a total of pre-hypertension/ hypertension 47.7%. Prevalence of pre-hypertension/hypertension was significantly higher among the males (47.6%) [UOR: 2.4 (1.6-3.6)], the age group of 40 years and above (39.8%) [UOR: 4.6 (2.8-7.6)], and married subjects (90.1%) [UOR: 3.2 (1.8-5.6)]. Those who perceived moderate/severe stress at work (32.5%) [UOR: 3.9 (2.3-6.6)], teaching work of 11 years and above (59.7%) [UOR: 4.0 (2.7-6.2)], inadequate intake of fruits/vegetables (81.7%) [UOR: 1.6 (1.0-2.6)], adding extra salt to food (56.0%) [UOR: 2.0 (1.4-2.9)], and those who were overweight/obese (67.5%) [UOR: 3.4 (2.2-5.1)] had a higher prevalence.

Conclusions:
The prevalence of pre-hypertension and hypertension was considerably high among school teachers, and several factors were significantly associated with hypertension. Coordinated efforts in early diagnosis, control, and prevention of hypertension among teachers are the need of the hour.
Intravenous Clonidine and Magnesium Sulphate in Attenuating Hemodynamic Response to Pneumoperitoneum During Laparoscopic Cholecystectomy: A Randomized Blinded Comparative Study
Authors: Rymbai Sharon Aylmer Lamare , Hazra Darpanarayan 
Published: April 2024

ABSTRACT

Background:
Conflicting data are demonstrating the superiority between Clonidine and Magnesium Sulphate in attenuating hemodynamic response to pneumoperitoneum.

Methods and Methodology:
This was a prospective randomized blinded trial comparing the efficacy of injection Clonidine 1.5 μg/kg (group A) and Magnesium Sulphate (MgSO4) 50 mg/kg (group B) done over six.

Results:
Sixty-eighty patients were included and assigned randomly to two groups of 34 (50.0%) patients. The mean (SD) age in groups A and B was 34.32 (11.35) and 37.20 (10.17) years respectively. Comparison of systolic blood pressure and mean arterial pressure were similar in both groups. The heart rate (HR) of patients in group A with group B, was almost the same at pre-induction and the end of infusion while HR was noted to be higher in group B, compared to group A at 5 minutes. Comparisons of EtCO2 (mm Hg) and SpO2 (%) between group A and group B were comparable in both the groups at pre-induction, at 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 35 min and 40 min. However, at the end of the infusion SpO2 levels were higher in Group A (p = 0.004). According to Modified Ramsay Sedation Score, half of the patients (50.0%) from group A were cooperative, oriented, and tranquil. In Group B, about one-third (38.2%) were cooperative, oriented, and tranquil. Immediate postoperative complications included nausea (8.8%) and vomiting (2.9%) which were comparable between both groups.

Conclusion:
Overall observations suggested that Clonidine (1.5 μg/kg) was equally effective as MgSO4 (50 mg/kg) in attenuating hemodynamic responses during pneumoperitoneum in laparoscopic cholecystectomy.
Prescription Audit for WHO Prescribing Indicators and Prescription Errors in a Tertiary Care Teaching Hospital
Authors: Mulkalwar Sarita , Patel Abhi , David Sudeep , Pabari Krushal , Math Praveen , Tilak Abhijeet V. 
Published: April 2024

ABSTRACT

Aim:
Our study aimed to audit prescriptions for the prescription indicators given by WHO and to analyze prescription errors, evaluating the frequency and types of prescription errors.

Methodology:
Prospective study was done in Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, under Pharmacology Department in October 2020. The prescriptions from all the OPD (outpatient departments) were collected from the pharmacy store. Prescriptions for the follow-up medication and devoid of medicine were excluded from the study.

Results:
Total of 1451 errors were found from 400 collected prescriptions, out of which 324 (22.3%) were errors of omission and 145 (10.0%) were errors of commission related to drugs whereas 982 (67.7%) were the error of omission other than drug details. A total of 1257 drugs were prescribed making an average of 3.14 drugs per prescription, out of which 28.72% drugs were prescribed by generic name. About 34.0% of patients were prescribed antibiotics and 2.25% of patients were prescribed injectable drugs. All the drugs were prescribed from the National Essential Drug List (NEDL).

Conclusion:
The prescription audit showed that there is a need to train prescribing doctors as per the standard MMC and NMC guidelines for rational prescription writing to minimize the chance of major errors like not writing the dose of the drug, not writing it in capital letters, drug-related instructions, diagnosis and so on. The prescription audit should be carried out at regular intervals to improve prescription writing skills to establish a better healthcare system.
Subtotal Cholecystectomy in Preventing Major Complications in Difficult Cholecystectomy Cases: A Comprehensive Single Center Study
Authors: Nagula Sunil , Sudhati Dilip , Jain Yugal D. , Patel Ravi V. 
Published: April 2024

ABSTRACT

Background:
Cholecystectomy is a commonly performed laparoscopic surgery but because of variability in anatomy, surrounding inflammation and fibrosis because of recurrent attacks of cholecystitis, can be a potentially difficult surgery. Laparoscopic total cholecystectomy in difficult gall bladder cases sometimes can cause severe complications. Laparoscopic subtotal cholecystectomy can be a bridge and a safe and feasible option between open subtotal cholecystectomy and laparoscopic cholecystectomy.

Aim:
To study indications, morbidity and clinical outcomes in patients undergoing subtotal cholecystectomy with laparoscopy or with open surgery.

Settings and Design:
It was a prospective observational study. Patients presenting with signs and symptoms of cholecystitis in either OPD or IPD and in emergency were included in this study.

Materials and Methods:
Total 38 patients who presented to our institute with clinical and ultrasonographic evidence of acute cholecystitis were included in the study. All patients underwent detailed and thorough clinical examination, laboratory investigations, ultrasonographic, and contrast enhanced computed tomography scan in selected patients. Based on intraoperative findings, decision of subtotal cholecystectomy either by laparoscopy or via open method was made. Various outcomes like intraoperative complications, postoperative complications and need of postoperative interventions, hospital stay, and returning to daily activity were observed and charted.

Statistical Analysis:
The data obtained were tabulated in Microsoft Excel and analyzed using SPSS version 17.0. Continuous variables were expressed as mean ± standard deviation value. Probability value (P value) was used to determine the level of significance. P value <.05 was considered as significant; P value <0.001 was considered as highly significant.

Results:
The common indications for subtotal cholecystectomy were severe cholecystitis with dense fibrous adhesions (97.4%), empyema (34.2%) or gangrenous gallbladder (31.6%), and Mirizzi syndrome (2.6%). Conversion rate was 21.1%. Morbidity rates were relatively low with subtotal cholecystectomy (bile leak 21.1%, sub hepatic collections 10.5%, retained stones 5.3%, paralytic ileus 18.4%, wound infection 7.9%, and common bile duct stricture 2.6%). Postoperative interventions were necessary in 18.4% of the cases (retained stones 5.3%, bile leak 7.9%, common bile duct stricture 2.6%, and subhepatic collection 2.6%). Mean duration of hospital stay was 7.5 days and returning to routine daily activity was 11.05 days.

Conclusion:
Subtotal cholecystectomy is a safe and feasible method for difficult gallbladder cases with a positive outcome. Laparoscopic subtotal cholecystectomy decreases the conversion rate in difficult gallbladder cases but it is not a substitute to open conversion if deemed necessary.
Utilizing Telemedicine as a Tool for Management of PLHIV at a Tertiary Care Institute
Authors: Kadam Dileep B. , Salvi Sonali P. , Rathod Tara B. , Chandanwale Ajay S. 
Published: April 2024

ABSTRACT

Telemedicine has been increasingly utilized in health sector. In our study we bring to light various applications of telemedicine consultation for patients receiving anti-retroviral therapy. We have observed that in a resource-limited setting, CD4-based assessment via telemedicine can still be useful, provided a serial record is maintained. We evaluated 430 cases in terms of demographics, CD4-trend and adverse effect profile. Tracking and monitoring of lost to follow-up cases could be done using this platform.

Aim:
The study focuses on the benefits of using telemedicine as a tool for consultation and referral of people living with HIV at centers located away from tertiary care institutes.

Settings and Design:
The study was conducted at telemedicine center, which is a tertiary referral center for all the districts in Maharashtra. We retrospectively analyzed the data obtained from telemedicine consultations carried out for patients from district-level antiretroviral therapy (ART) center.

Methods and Material:
The subjects who satisfied the following criteria were included for data analysis.

Inclusion Criteria:
All the HIV-infected persons on antiretroviral therapy enrolled at distant ART centers for which opinion was sought through telemedicine. This is an observational retrospective study. We reviewed the records of all patients enrolled in HIV healthcare through National Aids Control Organization from distant treating antiretroviral therapy centers (henceforth referred to as ART centers) for whom expert consultation was sought through telemedicine. These patients were given opinion for several consultations including response to therapy, management of opportunistic infections, drug-related adverse events, and treatment failure. We analyzed the demographics, the duration of treatment, and response to therapy.

Statistical Analysis Used:
Descriptive data analysis is used in this study.

Results:
We analyzed 430 case referrals through telemedicine from ART center. In 21% (N = 94) patients, CD4 was less than 50 and 11 cases had CD4 more than 500. An increasing CD4 trend was noted in 190 cases and a decreasing trend in 204 cases. In 36 cases, there was no change in CD4 progression. We had 20 cases lost to follow-up. The baseline regimen was Zidovudine Lamivudine Nevirapine (ZLN) in most cases (N = 237). Adverse drug reactions were the reasons for referral in 79 cases, maximum being AZT-induced anemia (N = 57). Of the total 430 cases referred, 253 cases had been wait-listed for SACEP meeting as per existing protocol. In 177 cases, physical attendance for the SACEP meeting could be deferred.

Conclusion:
Telemedicine has emerged as an immensely useful tool in management of People Living with HIV (PLHIV).
Uniqueness and Hyers–Ulam’s stability for a fractional nonlinear partial integro-differential equation with variable coefficients and a mixed boundary condition
Authors: Li Chenkuan 
Published: April 2024

Abstract
Introducing a pair-parameter matrix Mittag–Leffler function, we study the uniqueness and Hyers–Ulam stability to a new fractional nonlinear partial integro-differential equation with variable coefficients and a mixed boundary condition using Banach’s contractive principle as well as Babenko’s approach in a Banach space. These investigations have serious applications since uniqueness and stability analysis are essential topics in various research fields. The techniques used also work for different types of differential equations with initial or boundary conditions, as well as integral equations. Moreover, we present a Python code to compute approximate values of our newly established pair-parameter matrix Mittag–Leffler functions, which extend the multivariate Mittag–Leffler function. A few examples are given to show applications of the key results obtained.
Case Report: Mixed Airborne Contact Dermatitis–Chronic Actinic Dermatitis Pattern of Parthenium Dermatitis with Response to Tofacitinib Therapy
Authors: Khurana Ananta , Yadav Sheetal , Chanana Kunal , Sardana Kabir , Vidholiya Aakash 
Published: April 2024

ABSTRACT.
Parthenium hysterophorus is the commonest cause of plant dermatitis in India. It classically causes airborne contact dermatitis (ABCD), characterized by pruritic, eczematous, and lichenified lesions involving predominantly the face and flexural areas. Over time, however, a transition to chronic actinic dermatitis (CAD) pattern, with prominent involvement of sun-exposed sites, may occur. Management involves strict protective measures and topical and oral corticosteroids or immunomodulatory agents but often leads to only limited success. We report a patient with a chronic and extensive mixed ABCD-CAD pattern of parthenium dermatitis recalcitrant to conventional treatment, with rapid resolution after initiation of treatment with tofacitinib.
Prevalence and Characteristics of Plasmodium vivax Gametocytes in Duffy-Positive and Duffy-Negative Populations across Ethiopia
Authors: Little Ebony , Shenkutie Tassew T. , Negash Meshesha Tsigie , Abagero Beka R. , Abebe Abnet , Popovici Jean , Feleke Sindew Mekasha , Lo Eugenia 
Published: April 2024

ABSTRACT.
Plasmodium parasites replicate asexually in human hosts. The proportion of infections that carries gametocytes is a proxy for human-to-mosquito transmissibility. It is unclear which proportion of Plasmodium vivax infections in Duffy-negative populations carries gametocytes. We determined the prevalence and characteristics of P. vivax gametocytes in Duffy-positive and -negative populations across broad regions of Ethiopia. Finger-prick blood samples were collected for microscopic and molecular screening of Plasmodium parasites and Duffy status of individuals. Molecular screening of Plasmodium species and Duffy blood group genotyping was done using SYBR green and the Taqman quantitative polymerase chain reaction method. Of the 447 febrile patients who were shown to be P. vivax smear positive, 414 (92.6%) were confirmed by molecular screening as P. vivax and 16 (3.9%) of them were from Duffy-negative individuals. Of these, 5 of 16 (31.3%) Duffy-negative P. vivax–infected samples were detected with gametocytes. Of the 398 Duffy-positive P. vivax–infected samples, 150 (37.7%) were detected with gametocytes, slightly greater than that in Duffy-negative samples. This study highlights the presence of P. vivax gametocytes in Duffy-negative infections, suggestive of human-to-mosquito transmissibility. Although P. vivax infections in Duffy-negative individuals were commonly associated with low parasitemia, some of these infections were shown to have relatively high parasitemia and may represent a prominent erythrocyte invasion capability of P. vivax, and hidden reservoirs that can contribute to transmission. A better understanding of P. vivax transmission biology and gametocyte function particularly in Duffy-negative populations would aid future treatment and management of P. vivax malaria in Africa.
HARDWARE MODERN TRENDS RESEARCH FOR PREDICT THE MOMENT OF QUANTUM SUPERMACY
Authors: Hrytsyk Volodymyr , Dubuk Vasyl , Babii Oleksii 
Published: April 2024

The presented scientific research is the continuation of authors study is presented in [1], where the attempt for forecasting of quantum supermacy was presented. Appearance on few last years of mass introductions of new generation processors from one side and increase of qubits quantity from another side allow to enter corrections to prognoses. Breach introductions on last years create possibility to solve principally new problems, partially, in the field of minimization/nanomization of calculations. At the same time, such inventions put before us new difficulties, in particular in relation to the changes of rules at physics of cooperation of numerical elements and transfer of information [1-5].	We live at the epoch of next turn – cybernetics technologies – epoch of industrial revolution 4.0. The dynamics of new conceptions, methods and corresponding opportunities (theoretical and applied developments) appearance rapidly head for a point, when the society reaches to the moment, when conformities to law, which serve during centuries as science support will not able anymore describe the rules of cybernetic systems functioning and possibility to provide for information flows in 10-15 years confidently already today it is impossible to forecast, because principles of it distribution can be founded on principally new models, which are not developed today [4-6]. Researchers promise to solve complex numerical problems using quantum computers, when the problem of their up-scaling will be solved [6]. Similar to first digital computers, quantum computers can provide powerfull technologies in million one times more powerful, than present systems, but the key to success will consist in the transition from real problem-solving to quantum calculations
Identifikasi Genre Musik pada Platform Spotify dengan Menggunakan Metode K-Nearest NeighboR (KNN)
Authors: Mayuna Trimurti , Witanti Arita 
Published: April 2024

Music merupakan segalannya di-era digital sekarang,music dikatalan sebuah inspirasi dalam kehidupan ini, diakatakan juga merupakan media untuk menggunkapkan perasaaan dan pikiran melalui harmoni dan irama-irama yang bermacam-macam dan juga beragam, oleh karena itu dengan dengan banyaknya irama dan harmoni yang tercipta tersebut dalam music mempunyai berbagai unsur salah satunya genre pada music untuk mengkategorikan beberapa music yang harmoni dan iramanya hampir sama dijadikan menjadi satu,dalam era globalisasi ini music sudah bisa diakses dari beragam platform yang ada salah satunya pada platform yang sekarang banyak penggunanya yaitu Spotify,dari platform tersebut diadakan adanyan pengidentifikasi genre music menggunakan metode K-Nearest Neighbor(KNN) untuk mengelompokan beberapa lagu yang dijadikan dalam satu genre , pengidentifikasian ini diperuntunkan agar pengguna kedepannya dapat lebih dimudahkan dalam pencarian genre music sesuai genrenya, dan juga guna memberikan kemudahan pada platform spotify dalam mengelompokan serta mengidentifikasi lagu baru kedepannya sesuai genrenya melalui bagian pada lagu seperti acousticness,danceability,energy, dan speechiness.bedasarkan hasil data uji pada penelitian ini, hasil data uji menunjukan bahwa pada metode K-Nearset Neighbor (KNN) pada pengujian K1-K10 diperoleh hasil terbaik yaitu pada K1 dengan nilai akurasi adalah 90%.
Formulasi Sediaan Nutrasetikal Teh Celup Kombinasi Bunga Rosella (Hibiscus sabdariffa) dan Bunga Kenop (Globe amaranth) dengan Variasi Konsentrasi Stevia sebagai Perasa
Authors: Agustina Lia , Amaranggana Amalia Putri , Yuliati Ninis , Damayanti Nita 
Published: April 2024

Telah dilakukan penelitian formulasi nutrasetikal sediaan teh celup kombinasi bunga rosella (Hibiscus sabdarifa) dan bunga kenop (Globe amaranth) dengan variasi konsentrasi stevia sebagai perasa. Stevia dalam formulasi berfungsi sebagai pengganti gula dan memiliki aktivitas antioksidan. Penelitian ini bertujuan mengevaluasi pengaruh konsentrasi stevia pada kesukaan responden. Formula teh celup terdiri atas 0,7% bunga Rosella (Hibiscus sabdarifa) dan 1% bunga kenop (Globe amaranth) dengan variasi konsentrasi konsentrasi stevia yaitu 1,3% (Formula 1), 1% (Formula 2) dan 0,7% (Formula 3). Ekstrak bunga rosella (Hibiscus sabdarifa) dan bunga kenop (Globe amaranth) dievaluasi kandungan metabolit sekundernya. Formula teh celup dievaluasi dengan uji organoleptis, uji kadar air dan kesukaan responden. Hasil skrining fitokimia menunjukkan ekstrak bunga Rosela dan bunga Kenop mengandung flavonoid yang berfungsi sebagai antioksidan. Berdasarkan hasil penelitian menunjukkan bahwa bunga Rosella dan bunga Kenop dapat digunakan dalam formulasi nutrasetikal teh celup. Evaluasi organoleptis dari ketiga formula menunjukkan karakteristik bau khas teh, warna merah kecoklatan dan kadar air kurang dari 10% (sesuai dengan persyaratan dalam Materia Medika Indonesia). Hasil kesukaan pada responden menunjukkan bahwa warna, rasa, dan bau khas sediaan teh celup herbal dapat diterima. Dari hasil uji kesukaan juga menunjukkan bahwa formula kedua adalah yang paling banyak disukai oleh responden.