bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedizinische Anwendungen auf Blutspendeterminen
Authors: Meyer Oliver 
Published: February 2025

ZusammenfassungDie Hämotherapie-Richtlinie der Bundesärztekammer fordert bei der Durchführung
von Blutspendeterminen zwingend die physische Präsenz einer ärztlichen Person.
Allerdings wird es aufgrund des Ärztemangels immer schwieriger die Termine –
gerade in ländlichen Gebieten – adäquat mit Ärztinnen oder Ärzten zu besetzen.
Ein Ausweg aus dieser Situation könnte der Einsatz telemedizinischer Verfahren
sein, wie es auch im Transfusionsgesetz vorgesehen ist. Dieser Praxistipp fasst
die Ergebnisse einer Pilotstudie zusammen, die vom DRK-Blutspendedienst NSTOB
durchgeführt wurde. Im Rahmen dieser Studie wurden mobile Vollblutentnahmen
ärztlicherseits telemedizinisch betreut. Darüber hinaus war aber eine ärztliche
Person auf dem Termin präsent und die Spendewilligen konnten sich frei
entscheiden, ob sie telemedizinisch betreut werden wollten. In diesem Fall
erfolgten Anamnesegespräch und Tauglichkeitsfeststellung durch entsprechend
geschulte, nicht-ärztliche Mitarbeiter. Die Video-Kommunikation mit der
ärztlichen Person erfolgte über eine von der KBV zertifizierte
Videosprechstunden-Software. Von den 568 erschienenen Spendewilligen entschieden
sich 528 (92,9%) für die Variante der telemedizinischen Betreuung. Auf Grund der
geringen Spenderanzahl hat die Studie viele Limitation, es konnten aber wichtige
Erfahrungen gewonnen werden, welche räumlichen, technischen und personellen
Voraussetzungen erforderlich sind, um telemedizinisch betreute Blutspendetermine
erfolgreich durchführen zu können.
Sollten SGLT-2-Hemmer auch bei Dialysepatienten zum Einsatz kommen?
Authors: Wolf Gunter 
Published: February 2025

ZusammenfassungIn den letzten Jahren hat sich die Behandlung von Menschen mit Typ-2-Diabetes grundsätzlich geändert. Hier ist insbesondere die Organprotektion (Kardio- und Nephroprotektion) in den Vordergrund gerückt. So stellen SGLT-2-Inhibitoren (SGLT-2: „sodium glucose linked transporter 2“) nun die Basistherapie für diese Personengruppe dar. Das im November 2022 erschienene Update zu den Leitlinien der KDIGO (Kidney Disease: Improving Global Outcomes) zur Behandlung des Diabetes mellitus bei chronischen Nierenerkrankungen berücksichtigt diese Tatsache.
Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
Authors: Youssif Shaker , Shehta Wael , Alsaiari Norah A. , Farag Basant , Abdel-Aziz Marwa M. , Elfeky Sherin M , El-Kalyoubi Samar , Osman Nermine A. 
Published: February 2025

AbstractCondensation reaction of aromatic aldehydes with 2-(6-amino-2-chloropyrimidin-4-yl)isoindoline-1,3-dione and 2-(6-amino-2-hydrazineylpyrimidin-4-yl)isoindoline-1,3-dione afforded 2-(2-chloro-6-((3 alkylbenzylidene)amino) pyrimidin-4-yl)isoindoline-1,3-dione derivatives 6a–f and 2-(6-amino-2-(2-(arylidene)hydrazinyl)pyrimidin-4-yl)isoindoline-1,3-dione derivatives 8a–f, respectively, as phthalimide–aminopyrimidine hybrids. The compounds showed a wide range of antitubercular activities against sensitive MDR and XDR M. tuberculosis strains, with 8f and 6a showing the highest activity; these compounds inhibited sensitive M. tuberculosis with MIC of 0.48 and 0.98 μg/mL, respectively, comparable to isonizide (INH) (MIC = 0.12 μg/mL). Both 8f and 6a inhibited the MDR strain with MIC of 1.95 and 7.81 μg/mL, respectively, and XRD with MIC of 7.81 and 15.63 μg/mL, respectively. Both 8f and 6a inhibited mycobacterial InhA enzyme in vitro (IC50 = 0.717± 0.033 μM and 1.646± 0.069 μM, respectively). Molecular docking simulations revealed that 8f and 6a were also capable of interacting at the catalytic site of the InhA enzyme via binding with NAD+ and Tyr158, in a manner similar to that of the native ligand. Compounds 6a and 8f exhibited physicochemical properties of oral bioavailable drug-like compounds with high gastrointestinal absorption. Predictions showed that the compounds are unlikely to have side effects on the CNS and no anticipated hepatotoxicity, mutagenicity, or acute oral toxicity was identified in models.
Patellofemoral Instability: Preoperative Considerations and Postoperative Imaging
Authors: Atinga Angela , Wasserstein David , Sidhu Manpreet Singh , Tomescu Sebastian , Probyn Linda 
Published: February 2025

AbstractPatellofemoral instability is common, often affecting young female patients. It contributes to significant morbidity, such as pain and premature osteoarthritis. Patient presentation varies, from acute instability events to chronic/recurrent instability. This article provides a detailed description of the anatomy and biomechanics of the patellofemoral joint and relates it to the pathology of patellofemoral instability. There are well-recognized predisposing anatomical factors, such as trochlear morphology, patella height, excessive lateralization of the tibial tubercle, excessive valgus alignment, and femoral or tibial torsion.Diagnosis of patellofemoral instability requires a thorough clinical history and physical examination, combined with a multimodality imaging approach. Imaging is useful in surgical planning to define the severity of predisposing anatomical factors and to detect postoperative complications. The operative management of patellofemoral instability targets predisposing anatomical factors, such as medial stabilizing ligament reconstruction or repair, tibial tubercle osteotomy, femoral trochleoplasty, coronal plane realignment osteotomy, and torsional osteotomy.
Imaging of Reparable and Irreparable Rotator Cuff Tears
Authors: Murthy Sindhoora , Shen Michelle , Lemos Diego F. , Alaia Michael J. , Alaia Erin F. 
Published: February 2025

AbstractThis review offers a comprehensive discussion of magnetic resonance imaging (MRI) for the assessment of rotator cuff tendon repair and joint-preserving surgical options for patients with irreparable rotator cuff tears. Deciding to proceed with arthroscopic repair of a rotator cuff tendon tear is impacted both by clinical factors and morphological imaging features. Preoperative clinical and imaging features also predict the likelihood of success of a rotator cuff tendon repair and are important to recognize. In patients with irreparable rotator cuff tears and relatively preserved glenohumeral cartilage, various joint-preserving surgical options are available and seen increasingly in clinical practice.The acceptable range of postoperative imaging findings correlating with a functionally intact rotator cuff repaired tendon, and MRI findings that are either suggestive of or definitive for rotator cuff tendon repair failure are discussed in detail, with attention to the Sugaya classification. Ancillary features, such as progressive retraction of the myotendinous junction and the degree of muscle fatty atrophy, can be used as problem-solving tools in cases equivocal for rotator cuff retear. Finally, this review discusses in detail the most common joint-preserving treatment options for patients with irreparable rotator cuff tears, including an in-depth focus on superior capsular reconstruction.
Tophaceous Gout Mimicking a Neoplasm of the Patella
Authors: Vuurberg Gwendolyn , Rooy Jacky W.J. de , Vanhoenacker Filip M. 
Published: February 2025

AbstractTophaceous gout of the patella and extensor apparatus of the knee can mimic a musculoskeletal neoplasm. Considering gout, correlation with clinical history and presentation, and meticulous analysis of imaging semiology are key to a correct diagnosis. The most useful signs are periarticular erosion with overhanging edges, increased soft tissue on radiography and computed tomography, the “snowstorm sign” on ultrasound, variable signal and enhancement, bandlike infiltration of tendons, and osseous erosions with no or little bone marrow edema on magnetic resonance imaging. Dual-energy computed tomography is both a sensitive and specific tool for noninvasive characterization of gout and for differentiating other crystal arthropathies.
Imagem corporal e qualidade de vida após explante mamário
Authors: Figueiredo Raissa Barakatt de , Mariano Eduardo Machado , Murta Maria Madureira , Cintra-Junior Wilson , Ferreira Álvaro de Azevedo , Ching An Wan , Cezaretti José Antônio 
Published: February 2025

Resumo
Introdução Os implantes mamários de silicone foram introduzidos na prática cirúrgica na década de 1960 e são muito utilizados desde então, mas com porcentagem cada vez menor entre as cirurgias estéticas e com aumento da explantação. O objetivo deste trabalho é avaliar a imagem corporal e a qualidade de vida antes e após o explante.
Materiais e Métodos Aplicação dos questionários BREAST-Q e Questionário de Avaliação das Mamas no pré e pós-operatório de 11 pacientes submetidas a explante mamário.
Resultados Pelo BREAST-Q, utilizando uma escala de 0 a 100, a satisfação com as mamas aumentou de 52,3 para 64,3, e a satisfação com o resultado teve uma média de 85,9. Pelo Questionário de Avaliação das Mamas, utilizando uma escala de 1 a 5, a satisfação com a aparência das mamas teve aumento de 3,0 para 3,8.
Conclusão O estudo sugere melhora da imagem corporal após a explantação, mas necessita de mais dados para gerar conclusões relevantes.
Otorhinolaryngology Foundation: Three Decades of Excellence in Education, Research, and Scientific Advancement
Authors: Bento Ricardo Ferreira , Montefusco Adilson Marcos , Ribeiro Greice Vitória Garcia , Lowndes Annita Luz Lacerda , Fozzati Adriana de Almeida 
Published: February 2025

Abstract
Introduction The Otorhinolaryngology Foundation (FO), created in 1995, has played an important role in the advancement of otorhinolaryngology in Brazil, through initiatives in education, research, and service provision.
Objective To present the trajectory of FO's 30 years in public health and professional training, highlighting its contributions, historical milestones, and future challenges.
Brief History Created by the Center for Studies and Advanced Development in Otorhinolaryngology (CEDAO), the FO expanded its activities beyond academic support, becoming a national reference. Among its achievements, the commitment to the continuous improvement of teaching, research, publications, and provision of services to the community stands out. These initiatives include the promotion of courses and conferences that train thousands of professionals, the dissemination of knowledge through scientific publications, the development of innovative technologies, and the carrying out of campaigns and assistance actions aimed at the population.
Final Considerations The celebration of FO's 30th anniversary reaffirms its mission of excellence and innovation in the dissemination of knowledge in otorhinolaryngology in Brazil. The continuous commitment to improving its four fundamental pillars ensures quality in education, research, and service to society.
Técnica de Pellon em ferida crônica na região frontal: Um relato de caso e revisão da literatura
Authors: Daronch Oona Tomiê , Marcante Renata Fernanda Ramos , Palhares Aristides Augusto 
Published: February 2025

ResumoCélulas-tronco derivadas do tecido adiposo podem se diferenciar em fibroblastos, queratinócitos e outras células; eles também podem secretar mediadores com propriedades neoangiogênicas e anti-inflamatórias. Inicialmente descrita no tratamento de queimaduras, ao longo do tempo também começaram a ser empregadas no tratamento de feridas complexas O presente caso relata o uso da gordura para o tratamento de uma ferida crônica com exposição óssea traumática na região frontal, com três anos de evolução e 3 cm de extensão. Após duas sessões de lipoenxertia, a paciente apresentava granulação do tecido da região frontal. As propriedades de células-tronco do tecido adiposo podem ser aproveitadas não apenas no tratamento das queimaduras, mas também em feridas crônicas, como o caso do presente trabalho, no qual a exposição óssea era em área nobre, com poucas áreas doadores adjacentes e grande possibilidade de insucesso no caso de retalhos cutâneos.
Reabilitação de queimaduras em membros inferiores: Um estudo retrospectivo
Authors: Batista Katia Torres , Tavares Eduarda Cruz , Côrrea Giovanna Cristina Silveira , Carneiro-Júnior Gleubert Carlos , Silva Haysla Bias , Lima Pedro Henrique Borges de , Schwerz Renata Cristina Gontijo 
Published: February 2025

Resumo
Introdução As queimaduras estão entre as principais causas externas de morte registradas no Brasil, e a sua ocorrência nos membros inferiores é menos comum. Porém, caso ocorram queimaduras significativas nessa região, a reconstrução, sobretudo a tardia, é desafiadora, devido à dificuldade de se recriar a anatomia particular da região, o que dificulta a manutenção funcional do membro.
Materiais e Métodos Realizou-se uma análise retrospectiva de prontuários de pacientes vítimas de sequelas de queimaduras atendidos em um hospital de reabilitação de 2001 a 2005.
Resultados Foram avaliados 44 pacientes, dos quais 61,3% eram do gênero masculino e estavam na faixa etária de 21 a 40 (média de idade: 26) anos. Observou-se que 98% dos queimados estavam em idade produtiva (< 60 anos). Houve predomínio de agente causal térmico, e 65% dos pacientes foram submetidos a diferentes cirurgias e programas de reabilitação.
Conclusão A análise revelou deformidades severas, com comprometimento articular e amputações, em pacientes com tempo prolongado de queimadura, especialmente do sexo masculino, em idade produtiva e provenientes do Centro-Oeste, Norte e Nordeste. Os tratamentos necessários envolveram procedimentos cirúrgicos complexos e fisioterápicos para reabilitação, que variaram conforme o agente causal e a extensão da lesão, e foram priorizadas a funcionalidade do membro e a reintegração do paciente à sociedade.
Developing and validating a Women’s Health Index for India
Authors: Sehgal Meena , Jatrana Santosh , Johnson Louise 
Published: February 2025

Abstract
Developing a women’s health index is particularly important in the Indian context due to the pronounced disparities in women’s health across various social, economic, and geographical segments. This paper focuses on the development and validation of a comprehensive Women’s Health Index (WHI) for India. In contrast to previous efforts that predominantly focused on indicators related to pregnancy, childbirth, and the postpartum period, often limited to reproductive or maternal health services, our index adopts a multi-dimensional approach. The WHI comprises 17 variables, representing life stages of women and encompassing a diverse range of factors. Utilizing Principal Component Analysis, we computed the index and conducted statistical tests for internal and external validation. The spatial pattern of WHI reveals substantial inter-district and inter-state disparities. This study thus provides a valuable tool for characterizing women’s health and identifying health inequalities at a smaller administrative level in India.
Full asymptotic expansion of monodromy data for the first Painlevé transcendent: applications to connection problems
Authors: Long Wen-Gao , Jiang Yun-Jiang , Li Yu-Tian 
Published: February 2025

Abstract
We study the full asymptotic expansion of the monodromy data (i.e. Stokes multipliers) for the first Painlevé transcendent (PI) with large initial data or large pole parameters. Our primary approach involves refining the complex WKB method, also known as the method of uniform asymptotics, to approximate the second-order ODEs derived from PI’s Lax pair with higher-order accuracy. As an application, we provide a rigorous proof of the full asymptotic expansion of the nonlinear eigenvalues proposed numerically by Bender, Komijani, and Wang. Additionally, we present the full asymptotic expansion for the pole parameters

(

p

n

,

H

n

)

corresponding to the nth pole of the real tritronquée solution of the PI equation as

n
→
+
∞

.
Printed ultrasound sensors for enhanced structural health monitoring: development, characterization, and real-time evaluation
Authors: Brun Eliott , Dos Santos Elsa , Rival Guilhem , Cottinet Pierre-Jean , Pelletier Arnaud , Ducharne Benjamin 
Published: February 2025

Abstract
This study presents the development of ultrasound (US) sensors for structural health monitoring (SHM) by directly printing the sensors onto structural components. Unlike traditional ultrasound-based SHM systems, this approach minimizes sensor placement and environmental interference challenges, providing a stable, durable, and cost-effective solution for long-term monitoring of critical infrastructure. The core of this technology is a piezoelectric composite made of an OE 132–43/P189 mixture at 80 vol.% ferroelectric particles in a polyimide matrix, selected for its optimal dielectric strength, consistent d33 polarization, high-frequency response (1–20 MHz), and high thermal stability. Experimental validation showed that the printed sensors effectively measured component thickness in steel and aluminum, confirming their suitability for non-destructive evaluation. Additionally, multi-layer sensor designs were explored, producing higher acoustic pressure at lower operating voltages, enabling applications on thicker materials. This work advances SHM by enabling continuous, real-time monitoring, improving structural safety, and reducing maintenance costs across various industries.
The cosmological flow: a systematic approach to primordial correlators
Authors: Pinol Lucas , Renaux-Petel Sébastien , Werth Denis 
Published: February 2025

Abstract
The time evolution of primordial fluctuations conceals a wealth of insights into the high-energy physics at play during the earliest moments of our Universe, which is ultimately encoded in late-time spatial correlation functions. However, the conventional procedure to compute them is technically challenging, and a complete dictionary mapping the landscape of inflationary theories and the corresponding observable signatures is not yet available.
In this paper, we develop a framework to compute tree-level cosmological correlators based on following their time evolution from their origin as quantum zero-point fluctuations to the end of inflation.
From first principles, the structure of the bulk time evolution imposes a set of universal differential equations in time satisfied by equal-time correlators.
We automatise the process of systematically solving these equations. This allows us to accurately capture all physical effects and obtain exact results in theories formulated at the level of inflationary fluctuations that include any number of degrees of freedom with arbitrary dispersion relations and masses, coupled through any time-dependent interactions.
We then illustrate the power of this formalism by exploring the phenomenology of cosmological correlators emerging from the interaction with a massive scalar field.
After an extensive analysis of the quadratic theory and classifying perturbativity bounds, we study both the size and the shape dependence of non-Gaussianities in the entire parameter space, including the strong mixing regime. We present novel characteristics of cosmological collider signals in (would be) single-, double-, and triple-exchange three-point correlators. In the presence of primordial features, after subtracting gauge artefacts unavoidably generated by a breaking of scale-invariance, we show that soft limits of cosmological correlators offer a new possibility to probe the inflationary landscape. Finally, we provide templates to search for in future cosmological surveys.
BullFrog: multi-step perturbation theory as a time integrator for cosmological simulations
Authors: Rampf Cornelius , List Florian , Hahn Oliver 
Published: February 2025

Abstract
Modelling the cosmic large-scale structure can be done through numerical N-body simulations or by using perturbation theory. Here, we present an N-body approach that effectively implements a multi-step forward model based on Lagrangian Perturbation Theory (LPT) in a ΛCDM Universe. This is achieved by introducing the second-order accurate BullFrog integrator, which automatically performs 2LPT time steps to second order without requiring the explicit computation of 2LPT displacements. Importantly, we show that BullFrog trajectories rapidly converge to the exact solution as the number of time steps increases, at any moment in time, even though 2LPT becomes invalid after shell-crossing. As a validation test, we compare BullFrog against other N-body integrators and high-order LPT, both for a realistic ΛCDM cosmology and for simulations with a sharp UV cutoff in the initial conditions. The latter scenario enables controlled experiments against LPT and, in practice, is particularly relevant for modelling coarse-grained fluids arising in the context of effective field theory. We demonstrate that BullFrog significantly improves upon other LPT-inspired integrators, such as FastPM and COLA, without incurring any computational overhead compared to standard N-body integrators. Implementing BullFrog in any existing N-body code is straightforward, particularly if FastPM is already integrated.
Measurement of melting and freezing temperature of iron using radiation thermometry
Authors: Yang Inseok , Yoo Yong Shim , Kim Bong-Hak , Kim Sunghun , Kim Yong-Gyoo 
Published: February 2025

Abstract
This study presents precise measurements of the melting and freezing temperatures of pure iron (Fe) using radiation thermometry, aimed at improving temperature calibration techniques based on the International Temperature Scale of 1990 (ITS-90, t
90). A newly designed Fe cell, filled with Fe of 99.99% nominal purity and suitable for both radiation and thermocouple thermometry, was used to determine the t
90 temperature of the Fe liquidus transition. The melting and freezing transitions of Fe were measured using a calibrated radiation thermometer, with emissivity corrections made using a copper cell of identical structure. The measured melting and freezing points were 1533.79 °C and 1532.75 °C, respectively. Based on these measurements, we determined the transition temperature of Fe to be 1533.3 °C, with an expanded uncertainty (k = 2) of 0.8 K. Our result is 4 K lower than the widely accepted Fe transition temperature; however, apart from a few literature values used in calculating the recommended value, it is largely consistent with most previous findings. The Fe cell demonstrated high reproducibility and durability through multiple thermal cycles, establishing it as a cost-effective and practical alternative to palladium cells for calibration. Based on these findings, we recommend the use of Fe cells for fixed-point temperature calibration.
SOCRATES: a radiation-tolerant SoC generator framework
Authors: Andorno Marco , Caratelli Alessandro , Ceresa Davide , Denkinger Benoît , Kloukinas Kostas , Nookala Anvesh , Pejašinović Risto 
Published: February 2025

Abstract
As front-end ASIC complexity in HEP experiments grows, there is a shift towards more modular, programmable, and cost-effective designs. This work introduces the SOCRATES platform, a radiation-tolerant SoC generator toolset, based on SoCMake, a hardware/software build system that automates SoC assembly and verification. Utilizing existing IP blocks, SoCMake generates the SoC hardware and the software framework to run application code. The platform includes radiation-tolerant IPs and fault-tolerant extensions supporting redundancy and error correction. A prototype ASIC based on the RISC-V Ibex processor, generated using SOCRATES in a 28nm CMOS process, will validate the toolset through SEE and TID testing.