bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making it organic: the Garg Lab’s approach to excellence in research while teaching the next generation of chemists
Authors: Garg Neil 
Published: March 2024

Making it organic: the Garg Lab’s approach to excellence in research while teaching the next generation of chemists
The Garg Lab, nestled within UCLA’s Chemistry and Biochemistry department, is a pioneering force in organic chemistry research. Under the guidance of Professor Neil Garg, the Lab has achieved breakthroughs in synthetic methodologies, notably contributing to the total synthesis of complex molecules like lissodendoric acid and (-)N-Methylwelwitindolinone C isonitrile. This accomplishment showcases the Lab’s commitment to advancing the field.
Is there a Proteus of Nature?
Authors: De Bianchi Silvia 
Published: March 2024

Is there a Proteus of Nature?
PROTEUS studies the main strategies devised by Western philosophy in representing time in cosmology. It aims to modify current metaphysics and its relationship with cosmology in light of recent scientific debates in quantum gravity and quantum cosmology, thereby boosting new methods and research lines in the history and philosophy of cosmology. This objective has been achieved and gave rise to the COSMOS Network (https://cosmosproject.unimi.it/en/network/) and to the proposal of reinterpreting atemporality and the notion of ordering in philosophy.
Stem cell rejuvenation increases health- and lifespan
Authors: Florian Carolina 
Published: March 2024

Stem cell rejuvenation increases health- and lifespan
Cancer is a disease of the elderly, and chemotherapy remains the mainstay of treatment. Unfortunately, older patients are highly susceptible to specific toxicities of chemotherapy, like myelosuppression and life-threatening neutropenia. ReSinAge explores the possibility of improving the regenerative capacity of the aged stem cell niche as an unprecedented, innovative strategy to improve the haematopoietic recovery and increase the survival after chemotherapy in the elderly. More broadly, we aim to provide proof-of-concept evidence that increasing the regenerative potential of endogenous aged somatic stem cells represents an important strategy for rejuvenating tissues and improving health- and lifespan in the elderly.
Is the Atlantic Ocean circulation on the brink of a collapse?
Authors: Dijkstra Henk A. , Soons Jelle , Vanderborght Elian , Baars Sven , Smolders Emma , Jacques-Dumas Valérian , Esclapez Lucas , Boot Amber , van Westen René M. 
Published: March 2024

Is the Atlantic Ocean circulation on the brink of a collapse?
The TAOC project aims to determine the probability that the Atlantic Ocean circulation will collapse under climate change before the year 2100. A hierarchy of ocean-climate models will be used to which we will apply modern rare event techniques.
Building credibility of computational models in cardiovascular medicine through verification and validation
Authors: Setzu Romano , Olivares Andy , Mill Jordi , Albors Carlos , Camara Oscar , Valen-Sendstad Kristian , Mora Maria Teresa , Trenor Beatriz , Sermesant Maxime , Barbier Michèle 
Published: March 2024

Building credibility of computational models in cardiovascular medicine through verification and validation
Cardiovascular diseases affect 15 million people in Europe and digital solutions are now seen as very useful tools in the search for new drugs and medical devices. SimCardioTest is a 4-year project funded by the European Commission that aims to develop credible computer modelling and simulation approaches on a cloud-based platform for testing cardiac drugs and devices in silico.
PROGRAM PENDAMPINGAN LITERASI, ADAPTASI TEKNOLOGI, ADMINISTRASI DI SMP N 3 SELUMA
Authors: Moh rere valentino zantohar  
Published: March 2024

Program Merdeka Belajar Kampus Merdeka ( MBKM ) adalah salah satu program yang diselenggarakan oleh kemendikbud. Program kampus mengajar merupakan salah satu program dalam Program Merdeka Belajar Kampus Merdeka yang memiliki tujuan untuk mengajar, membantu teknologi, dan membantu administrasi sekolah dan guru. Salah satu sekolah yang menjadi sasaran dari program Kampus Mengajar adalah SMP N 3 Seluma Pada program Kampus Mengajar ini, mahasiswa yang ditunjuk untuk mengikuti program memiliki tanggung jawab dalam membantu pihak sekolah dalam proses mengajar, membantu adaptasi terhadap teknologi, dan membantu administrasi sekolah. Selain itu, mahasiswa Kampus Mengajar memiliki tanggung jawab dalam memperbaiki karakter siswa dan meningkatkan minat belajar siswa selama masa pandemi ini. Tujuan dari keikutsertaan mahasiswa dalam program Kampus Mengajar ini merupakan sebuah proses dalam menambah hubungan, menambah pengalaman di luar dunia perkuliahan, mengembangkan wawasan, karakter dan soft skill mahasiswa, mendorong dan memacu pembangunan nasional dengan menumbuhkan motivasi siswa untuk berpartisipasi dalam pembangunan, serta meningkatkan peran dan kontribusi nyata perguruan tinggi dan mahasiswa dalam pembangunan pendidikan di Indonesia.
Kata Kunci : Kampus Mengajar, Adaptasi Teknologi, Minat Belajar Siswa
تأثير استخدام تمرينات بوسائل مساعدة لزيادة المدى الحركي للذراعين لدى لاعبي التجديف 2000متر
Authors: اياد عبد اللطيف علي  
Published: March 2024

هدفت الدراسة التعرف إلى اعداد تمرينات باستخدام وسائل مساعدة لزيادة المدى الحركي للذراعين لدى لاعبي التجديف والتعرف على تأثير التمرينات بوسائل مساعدة على زيادة المدى الحركي للذراعين لدى لاعبي التجديف،بالاستناد الى الملاحظة التي تم ان توظيف المدى الحركي للذراعين عند لاعب التجديف اثناء اداء الجدفة بالشكل الصحيح يؤدي الى زيادة حركة مفصل الكتف وكان لابد من تتبع هذه الاشكالية وملاحظة تاثيرها على المدى الحركي للجدفة وتحسين الانجاز الرقمي واستخدم الباحث المنهج التجريبي، وتكون مجتمع الدراسة من (10) لاعبين، حيث تكونت عينة الدراسة من (6) لاعبين وتم اختيارهم بالطريقة العمدية، واستنتج الباحث ان استخدام التمرينات المساعدة ادى الى زيادة المدى الحركي لعضلات ومفاصل الذراعين وان تأثير الوسائل المساعدة من اجهزة وادوات ادت الى زيادة نسبة وفاعلية الاداء وارتفاع القابلية البدنية في تحسين مدى الحركة، وهذا ما يحقق احد اهداف التنمية المستدامة للامم المتحدة في العراق (الصحة الجيدة). واوصى الباحث الى التأكيد على استخدام الوسائل المساعدة لما لها من دور في تطوير قابلية العضلات والمفاصل على الاداء الحركي فضلا عن التأكيد على استخدام اجهزة التصوير والتحليل لتشخيص جزئيات.
Chemical profiling of bioactive compounds in the methanolic extract of wild leaf and callus of Vitex negundo using gas chromatography-mass spectrometry
Authors: Garg Gunjan , Bharadwaj Alok , Chaudhary Shweta , Gupta Veena 
Published: March 2024

BACKGROUND
The investigation of plant-based therapeutic agents in medicinal plants has revealed their presence in the extracts and provides the vision to formulate novel techniques for drug therapy. Vitex negundo (V. negundo ), a perennial herb belonging to the Varbanaceae family, is extensively used in conventional medication.
AIM
To determine the existence of therapeutic components in leaf and callus extracts from wild V. negundo plants using gas chromatography-mass spectrometry (GC-MS).
METHODS
In this study, we conducted GC-MS on wild plant leaf extracts and correlated the presence of constituents with those in callus extracts. Various growth regulators such as 6-benzylaminopurine (BAP), 2,4-dichlorophenoxyacetic acid (2,4-D), α-naphthylacetic acid (NAA), and di-phenylurea (DPU) were added to plant leaves and in-vitro callus and grown on MS medium.
RESULTS
The results clearly indicated that the addition of BAP (2.0 mg/L), 2,4-D (0.2 mg/mL), DPU (2.0 mg/L) and 2,4-D (0.2 mg/mL) in MS medium resulted in rapid callus development. The plant profile of Vitex extracts by GC-MS analysis showed that 24, 10, and 14 bioactive constituents were detected in the methanolic extract of leaf, green callus and the methanolic extract of white loose callus, respectively.
CONCLUSION
Octadecadienoic acid, hexadecanoic acid and methyl ester were the major constituents in the leaf and callus methanolic extract. Octadecadienoic acid was the most common constituent in all samples. The maximum concentration of octadecadienoic acid in leaves, green callus and white loose callus was 21.93%, 47.79% and 40.38%, respectively. These findings demonstrate that the concentration of octadecadienoic acid doubles in-vitro compared to in-vivo . In addition to octadecadienoic acid; butyric acid, benzene, 1-methoxy-4-(1-propenyl), dospan, tridecanedialdehyde, methylcyclohexenylbutanol, chlorpyrifos, n-secondary terpene diester, anflunine and other important active compounds were also detected. All these components were only available in callus formed in-vitro . This study showed that the callus contained additional botanical characteristics compared with wild plants. Due to the presence of numerous bioactive compounds, the medical use of Vitex for various diseases has been accepted and the plant is considered an important source of therapeutics for research and development.
Evaluating serum CXCL12, sCD22, Lp-PLA2 levels and ratios as biomarkers for diagnosis of Alzheimer's disease
Authors: Liu Zeng-Ling , Hua Fei-Fei , Qu Lei , Yan Na , Zhang Hui-Fang 
Published: March 2024

BACKGROUND
Grasping the underlying mechanisms of Alzheimer's disease (AD) is still a work in progress, and existing diagnostic techniques encounter various obstacles. Therefore, the discovery of dependable biomarkers is essential for early detection, tracking the disease's advancement, and steering treatment strategies.
AIM
To explore the diagnostic potential of serum CXCL12, sCD22, Lp-PLA2, and their ratios in AD, aiming to enhance early detection and inform targeted treatment strategies.
METHODS
The study was conducted in Dongying people's Hospital from January 2021 to December 2022. Participants included 60 AD patients (AD group) and 60 healthy people (control group). Using a prospective case-control design, the levels of CXCL12, sCD22 and Lp-PLA2 and their ratios were detected by enzyme-linked immunosorbent assay kit in the diagnosis of AD. The differences between the two groups were analyzed by statistical methods, and the corresponding ratio was constructed to improve the specificity and sensitivity of diagnosis.
RESULTS
Serum CXCL12 levels were higher in the AD group (47.2 ± 8.5 ng/mL) than the control group (32.8 ± 5.7 ng/mL, P < 0.001), while sCD22 levels were lower (14.3 ± 2.1 ng/mL vs 18.9 ± 3.4 ng/mL, P < 0.01). Lp-PLA2 levels were also higher in the AD group (112.5 ± 20.6 ng/mL vs 89.7 ± 15.2 ng/mL, P < 0.05). Significant differences were noted in CXCL12/sCD22 (3.3 vs 1.7, P < 0.001) and Lp-PLA2/sCD22 ratios (8.0 vs 5.2, P < 0.05) between the groups. Receiver operating characteristic analysis confirmed high sensitivity and specificity of these markers and their ratios in distinguishing AD, with area under the curves ranging from 0.568 to 0.787.
CONCLUSION
Serum CXCL12 and Lp-PLA2 levels were significantly increased, while sCD22 were significantly decreased, as well as increases in the ratios of CXCL12/sCD22 and Lp-PLA2/sCD22, are closely related to the onset of AD. These biomarkers and their ratios can be used as potential diagnostic indicators for AD, providing an important clinical reference for early intervention and treatment.
Deliberate self-harm among pediatric psychiatric inpatients in China: A single-center retrospective study
Authors: Jiang Xing-Zhi , Li Huan-Huan , Yu Zhen-Zhen , Wang Chen 
Published: March 2024

BACKGROUND
For children and adolescents, deliberate self-harm (DSH) is becoming a mental health problem of concern. Despite several studies on the prevalence and factors of DSH in the world, there is little information on DSH among children and adolescents in China. This study explores the prevalence, types, associated risk factors and tendency of DSH in pediatric psychiatric inpatients in China.
AIM
To understand the situation of DSH among hospitalized children and adolescents and its related factors.
METHODS
In this study, we retrospectively studied 1414 hospitalized children and adolescents with mental illness at Xiamen Mental Health Center from 2014 to 2019, extracted the demographic and clinical data of all patients, and analyzed clinical risk factors of DSH.
RESULTS
A total of 239 (16.90%) patients engaged in at least one type of DSH in our study. Cutting (n = 115, 48.12%) was the most common type of DSH. Females (n = 171, 71.55%) were more likely to engage in DSH than males (n = 68, 28.45%). DSH was positively associated with depressive disorders [OR = 3.845 (2.196-6.732); P < 0.01], female [OR = 2.536 (1.815-3.542); P < 0.01], parental marital status [OR = 5.387 (2.254-12.875); P < 0.01] and negative family history of psychiatric illness [OR = 7.767 (2.952-20.433); P < 0.01], but not with occupation, substance use and history of physical abuse.
CONCLUSION
Our findings suggest that for patients with depression, females, an abnormal marriage of parents, and no history of mental illness, attention should be paid to the occurrence of DSH.
Optimization of nursing interventions for postoperative mental status recovery in patients with cerebral hemorrhage
Authors: Tang Jin-Li , Yang Wei-Wei , Yang Xiao-Yang 
Published: March 2024

BACKGROUND
Hypertensive cerebral hemorrhage (HCH), the most common chronic diseases, has become a topic of global public health discussions.
AIM
To investigate the role of rehabilitative nursing interventions in optimizing the postoperative mental status recovery phase and to provide clinical value for future rehabilitation of patients with HCH.
METHODS
This randomized controlled study included 120 patients with cerebral HCH who were contained to our neurosurgery department between May 2021–May 2023 as the participants. The participants have randomly sampled and grouped into the observation and control groups. The observation group received the rehabilitation nursing model, whereas the control group have given conventional nursing. The conscious state of the patients was assessed at 7, 14, 21, and 30 d postoperatively. After one month of care, sleep quality, anxiety, and depression were compared between the two groups. Patient and family satisfaction were assessed using a nursing care model.
RESULTS
The results showed that the state of consciousness scores of the patients in both groups significantly increased (P < 0.05) after surgical treatment. From the 14th day onwards, differences in the state of consciousness scores between the two groups of patients began to appear (P < 0.05). After one month of care, the sleep quality, anxiety state, and depression state of patients were significantly better in the observation group than in the control group (P < 0.05). Satisfaction with nursing care was higher in the observation group than in the control group (P < 0.05).
CONCLUSION
The rehabilitation nursing model has a more complete system compared to conventional nursing, which can effectively improve the postoperative quality of life of patients with cerebral hemorrhage and improve the efficiency of mental state recovery; however, further analysis and research are needed to provide more scientific evidence.
PROPHETIC MEDICINE AND HERBS IN ORAL CARE A REVIEW OF LITERATURE
Authors: Hashmi Arshee 
Published: March 2024

Prophetic medicine comprises the teaching of the prophet Mohammad with regards to nutrition, hygiene, sickness, cure and prevention of the ailments. “Whenever the Prophet (ﷺ) would visit an ill person, he would said:‘[O Allah,] make the harm go away, Lord of mankind, and heal him, You are the Healer, there is no healing except your healing, a healing that does not leave any sickness. Healing with the Medicine of the Prophet (PBUH) is the remedy for well-being, good health and soul. Prophetic medicines promote healing, prevention and cure of ailments. The review article is an effort to explore detailed analysis of prophetic medicines and natural herbs in oral care. The article is focused on the uses of miswak, honey, black seed, olives, senna and idhkhir for oral therapeutic uses. The studies, experiments and research have demonstrated that the prophetic medicines and herbs provide benefits in oral care. However, the research conducted on some herbs are limited to in vitro studies, thus further studies are required to be carried out on animals or humans to achieve accurate results. Furthermore, other herbs mentioned in prophetic medicines like tannumah (aloes), daghabis (dill seed), dates, cortus, need to be explored and further studied for therapeutic use in oral care.
EFFECTIVENESS OF ACUPUNCTURE IN THE TREATMENT OF CHRONIC LOW BACK PAIN (LBP): LITERATURE REVIEW
Authors: Taqi Muhammad Bariq , Rianzie Raissa , Pinta Gracia Regina , Salsabila  , Septadina Indri Seta 
Published: March 2024

Chronic Low Back Pain (CLBP) or Low Back Pain (NPB) is pain between the costal and gluteal margins that persists for over three months. LPB is a common disease. Fifty percent of the world's population is estimated to experience LBP by 30, and 70% of the population will experience LBP at some point in their adulthood. There is no gold standard for LBP therapy, so the therapy needed depends on the patient. One of the therapies used is acupuncture therapy. In a randomized clinical trial, acupuncture therapy demonstrated greater effectiveness in reducing pain intensity for patients with chronic LBP compared to administering oral baclofen at a dose of 30 mg/day. Another study in Germany with 1162 research subjects also found that providing acupuncture therapy in the treatment of chronic LBP had more significant efficacy on the patient's pain and functional status than conventional therapy.
The Unforeseen Cost of Brexit – Customs
Authors: Grainger Andrew 
Published: March 2024

“Take back control” was one of the Leave campaign’s main battle cries in Britain’s referendum on EU membership. But reintroducing customs controls on UK-EU trade will have a cost for both business and government. Although it is not yet clear what Brexit will look like, the added costs from trade-related red tape that will result from leaving the EU are certain. And these costs are likely to be significant without adequate reform to customs procedures. At present, all goods entering the UK from outside the EU require an import declaration. The most common and practical way of complying is to use the logistics providers carrying the goods as agents. Their fees are often dependent on the specific commercial arrangements, but can range from just a few pounds to £25 plus for declaring a sea container. Once Brexit is in place, UK-EU trade will be subject to similar costs. According to the World Customs Organisation’s latest Annual Report for 2015-16, the UK made 70.5m import declarations and 6.5m export declarations per year. Based on current trade figures it would be fair for UK Customs (HMRC) to expect the number of customs declarations to double once Britain leaves the EU. A corresponding increase in declarations would also arise on the continent since each export declaration at one end of the supply chain is followed by an import declaration at the other. Further analysis is required, but it is easy to imagine an additional cost to UK-EU trade in the order of several billion pounds per year. Then there is also the risk of physical inspections. Depending on the nature and duration of the inspection, these costs could be anywhere between £52 and £1,540 per consignment. Ports would need to accommodate the increased demands for inspection facilities. This would be at the expense of losing valuable space for commercial activities.
O contexto da aprendizagem remota emergencial na Baixada Santista durante a pandemia de Sars-CoV-2
Authors: Silva Marcos Rafael da , Prado Clara Versiani dos Anjos , Silva Tathianni Cristini da 
Published: March 2024

O artigo apresenta pesquisa realizada entre novembro e dezembro de 2020, junto a professores e estudantes da Região Metropolitana da Baixada Santista - RMBS, que investigou impactos e percepções dos caminhos adotados para aprendizagem remota emergencial no contexto da pandemia de SARS COV 2. Os dados foram coletados através de formulários disponibilizados eletronicamente, respondidos por 116 professores e 111 alunos das redes municipais de ensino da RMBS e confrontados com outras pesquisas realizadas em 2020, no Brasil e no exterior. O artigo oferece um panorama geral da experiência trilhada na RMBS, apresentando propostas para novas investigações e ações.
The Financial Performance Assessment Using the Camel Method PT. Bank Rakyat Indonesia Tbk, Cabang Rantepao Toraja Utara
Authors: Sudirman Irmayanti 
Published: March 2024

Tujuan penelitian ini yaitu untuk mengetahui mengetahui kinerja keuangan ditinjau dari metode Camel pada PT. Bank Rakyat Indonesia (persero), Tbk Cabang Rantepao Toraja Utara dalam kategori sehat.
Metode penelitian yang digunakan dalam penelitian ini yaitu deskriptif kuantitatif. Sumber data yang digunakan yaitu data sekunder yang bersumber dari dari laporan laba rugi dan neraca perusahaan PT. Bank Rakyat Indonesia (persero), Tbk Cabang Rantepao Toraja Utara.
Adapun hasil penelitian menunjukkan bahwa setelah melakukan perhitungan dan analisis pada masing-masing aspek CAMEL (Capital, Asset, Management, Earning, Liquidity) maka dapat ditarik kesimpulan bahwa unsur-unsur yang termasuk didalam camel dengan nilai-nilainya memiliki masing-masing peran yang sangat penting dalam penentuan layak atau tidaknya suatu bank beroperasi. Dari hasil yang diperoleh terlihat bahwa semua nilai akhir camel selama 3 tahun terakhir dimulai dari tahun 2019 sampai dengan tahun 2021 mengalami perubahan tiap tahunnya akan tetapi semua nilai akhir masih berada pada predikat sehat karena berada pada rentang angka 81-100 dengan demikian dapat disimpulkan bahwa kinerja keuangan PT. Bank Rakyat Indonesia (Persero) Tbk, Cabang Rantepao Toraja Utara dengan menggunakan metode CAMEL berada dalam predikat sehat.
ANALYSIS OF TEACHER BARRIERS IN THE IMPLEMENTATION OF CURRICULUM MERDEKA IN SECONDARY SCHOOLS
Authors: Saputra Andra , Gistituati Nurhizrah , Ambiyar Ambiyar , Bentri Alwen , Aziz Ishak , Hidayati Abna 
Published: March 2024

Penelitian ini bertujuan untuk menganalisis faktor-faktor hambatan yang dihadapi oleh guru dalam mengimplementasikan Kurikulum Merdeka di Sekolah Menengah. Adapun faktor hambatan yang dianalisis ditinjau dari beberapa aspek yang disesuaikan dengan literatur yaitu; Aspek pemahaman guru terhadap filosofi dan tujuan Kurikulum Merdeka, aspek keterampilan pedagogis guru, aspek kesiapan teknologi guru, aspek kolaborasi antar guru, aspek dukungan administratif, aspek partisipasi orang tua, aspek ketersediaan sumber daya. Penelitian menggunakan pendekatan kualitatif survei dengan desain studi kasus, penelitian ini melibatkan guru-guru terpilih sebagai partisipan, yang memberikan wawasan mendalam melalui wawancara mendalam, observasi kelas, dan analisis dokumen. Hasil penelitian menunjukan aspek pemahaman guru terhadap filosofi dan tujuan Kurikulum Merdeka dengan persentase 83,60%, aspek keterampilan pedagogis guru dengan persentase 85,20%, aspek kesiapan teknologi guru dengan persentase 79,33%, aspek kolaborasi antar guru dengan persentase 84,27%, aspek dukungan administrative dengan persentase 85,73%, aspek partisipasi orang tua dengan persentase 86,27%, aspek ketersediaan sumber daya dengan persentase 85,33%. Penelitian ini menyediakan landasan bagi perubahan kebijakan dan pendekatan pendidikan untuk mengatasi hambatan-hambatan ini. Kesimpulan menekankan perlunya pelatihan yang lebih baik, dukungan administratif yang konsisten, dan kolaborasi yang diperkuat antara guru, pihak sekolah, dan orang tua untuk memastikan suksesnya implementasi Kurikulum Merdeka di Sekolah Menengah.