bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conhecimento para apoio aos profissionais responsáveis pelo diagnóstico de citologia anal: revisão narrativa e interpretação de critérios citomorfológicos
Authors: PEREIRA SANTOS WILLIAM , ELEUTÉRIO JUNIOR JOSÉ 
Published: February 2024

Introdução: O câncer anal é uma patologia considerada rara, apesar de crescente na população. A citologia anal tem sido uma aposta para diagnosticar as alterações pré-neoplásicas, evitando a evolução ao câncer. Objetivos: I) Abordar aspectos de satisfatoriedade da amostra celular e revisar os critérios citomorfológicos dos achados benignos e malignos nos esfregaços de citologia anal. II) Tornar este artigo um instrumento de suporte aos profissionais de saúde que atuam no setor de Citopatologia vinculados ao Sistema Único de Saúde (SUS) ou à iniciativa privada. Métodos: Revisão narrativa, com busca nas bases PubMed, Science Direct e SciELO, de fevereiro a abril/2023. Desenvolvimento: A análise da literatura aponta para a aplicação da citologia anal para diagnóstico das alterações induzidas pelo Papilomavírus Humano (HPV) no canal anal. O rastreamento se baseia na semelhança ao controle do câncer de colo uterino e à história natural da doença, reconhecendo que as lesões precursoras evoluem ao câncer invasivo. Essa janela entre a lesão e o câncer abre espaço para detecção precoce. Oportunamente, a técnica pode diagnosticar agentes responsáveis por outras Infecções Sexualmente Transmissíveis (IST). Conclusão: Qualificar os laudos de diagnóstico citopatológico pode apoiar o cuidado desde a atenção primária. O intuito deste trabalho foi contribuir com o processo de aprendizagem dos profissionais da saúde e apoiar a saúde pública nas estratégias de garantia de cuidado às pessoas.

Palavras-chave: Ânus; Câncer anal; Citologia; Esfregaço de Papanicolaou; Papilomavírus Humano (HPV).
Od salonu do buduaru. Wystrój i wyposażenie wnętrz łódzkiej burżuazji 1890–1939 – wybrane problemy
Authors: Grzejszczak Łukasz 
Published: February 2024

U progu XX stulecia w strukturze społecznej łódzkiego mieszczaństwa dominowała grupa drobnomieszczaństwa, której odsetek wynosił 20%, wywodząca się z niej burżuazja stanowiła około 7%, a odsetek przedstawicieli zamożnej inteligencji szacuje się na około 2,2–5%.
W początkowym okresie, tworząc własny styl życia, wyemancypowane mieszczaństwo aspirowało do wzorów czerpanych z wyższych warstw społecznych, zwłaszcza arystokracji. Elegancja i wykwintność – co podkreśla Norbert Elias – będąc podstawą prestiżu, pozwalają mieszczaństwu, tak jak w przeszłości arystokracji, oddzielić się od innych warstw społecznych. Jednym z elementów budujących społeczny prestiż było posiadanie odpowiednio wyposażonej siedziby, jak zauważa Walter Benjamin „wnętrze jest dla osoby prywatnej czymś w rodzaju wszechświata. W nim gromadzi ona to, co dalekie i co przeszłe”. Wnętrze mieszkalne jest bowiem przestrzenią o ściśle wyznaczonych granicach i funkcjach, które mają służyć nie tylko zaspokajaniu podstawowych ludzkich potrzeb, ale także pragnienia wygody. Odzwierciedla się ono w funkcji reprezentacyjnej, której sprzyja prowadzenie życia towarzyskiego, nieograniczonego jedynie do rozgałęzionej rodziny, ale obejmującego znacznie szerszą wspólnotę.
Artykuł ma przybliżyć problematykę związaną z wystrojem i wyposażeniem wnętrz zarówno rezydencji, jak i zamożnych mieszkań, mających głównie charakter neostylowy, podporządkowany określonym treściom, wśród których dominowała chęć autoprezentacji. Podjęto w nim rozważania dotyczące kategorii porządkujących – w pewnym sensie – układ i wygląd oraz sposób urządzenia poszczególnych pomieszczeń. Czy były to tylko zmieniające się mody, czy też uniwersalny pierwiastek skupiający się wokół reprezentacyjności i prywatności? Zaprezentowano także wyniki badań związanych z kulturą materialną, wyposażeniem, programem ikonograficznym wnętrz oraz obyczajowością. Chcąc przedstawić omawiane zagadnienia, odwołano się do materiałów archiwalnych, ikonograficznych, relacji pamiętnikarskich i wspomnień. Skupiono się też na różnorodności wyposażenia, omawiając nie tylko meble.
Confiabilidade das medições obtidas em radiografias panorâmicas para determinação automatizada de gênero
Authors: Michel-Crosato Edgard , Ortiz Adrielly Garcia , Haye Biazevic Maria Gabriela 
Published: February 2024

Introduction: forensic anthropology currently serves as a potent tool in primary and secondary identification, especially in mass disasters, increasingly common in our society. Objective: Verify the reproducibility of measured measurements. proposes methods of personal identification. Method: to verify the reliability of the method, 25 radiographs were selected, the intra-class coefficient (ICC) and the Bland-Altiman statistical technique were calculated. accuracy of the method, was used. R studio and Medcalc were used. Results: The ICC was above 0.90 for all measurements. According to the Bland-Altman analysis, the average differences observed between examiners ranged from 0.017 (m5) to 0.020 (m7). These results highlight the reliability of measurements made by two different examiners performing the same tasks. Conclusion: The variables used in this study have shown satisfactory reproducibility. Thus, the selected and evaluated data can be used as metadata in automating the gender determination process from panoramic radiographs.
AN INTEGRATIVE LITERATURE REVIEW OF THE POTENTIAL TECHNICAL CHALLENGES IN FORENSIC ODONTOLOGY PRACTICE – AN EXPLORATORY STUDY
Authors: Viraliyur Ramaswami Sweta , Franco Ademir , Manica Scheila 
Published: February 2024

Forensic Odontology deals with the presentation of dental evidence in a court of law. An academic exploration revealed instances of technical challenges within the field. This study endeavours to delve into the spheres where these challenges occur, with the core objective of enhancing the quality of practice. An integrative literature review was conducted using the online platforms SCOPUS and Web of Science. Based on the selection criteria, 29 pertinent papers dated 2000-2023 were included. Quantitative analysis of the categories of selected articles was performed using Microsoft Excel 2019 (Microsoft Corp., Redmond, WA, USA). Technical concerns were reported in all facets of Forensic Odontology with the general role of expert witnesses being reported the most (n=8; 27.58%). Within the different facets of the field, age estimation was the most prominent area of concern (n=8; 27.58%) and child abuse and neglect (n=1; 3.57%) represented the least reported category. Findings indicate that there is a need to prioritize avenues to enhance the quality of practice in the general role of expert witnesses and the specific area of dental age estimation. To this end, increased support for researchers must be provided to help validate methodologies. It is advisable to institute mandatory formal training and proficiency testing within the field. Inadequate knowledge of dentists regarding child abuse and neglect has been noted, demonstrating the need for more dedicated quality training. Recommendations for Forensic Odontologists have been curated combining this study's results and the codes of ethics of various forensic organisations
From Design to Experimental Validation of the Fully Mechanical Gravity Tool Face Measurement-While-Drilling System
Authors: Qu Jun , Xue Qilong , Wang Jin , Sun Jinchao , Lu Jintao , Zhang Haiping , Sun Feng , Tao Xinghua 
Published: February 2024

Summary
Exploiting geothermal resources such as hot dry rocks (HDRs) requires directional drilling technology. Measurement-while-drilling (MWD) technology plays a crucial role in directional measurement. However, its high temperature and environment limit downhole measurement instruments in application. For this research, we designed an MWD system with a mechanical gravity tool face, and the fully mechanical structure was used to overcome the high-temperature constraints. The bias stabilization platform, gravity tool face coding method, and mud pulse generation structure were designed. The eccentric stable model and pulse generation structure model were established through numerical analysis, and a gravity tool face angle coding and identification method was also established. The experimental prototype testing system was built on theoretical analysis and hydrodynamics. The feasibility of the tool functions and the recognition algorithm were verified experimentally, with a maximum measurement error of 6° and an average measurement error of 2.6°. The average measurement error of the system in the well test is 6°, which verifies the reliability of the system.
WITHDRAWN: Impact of Dark Current on Pinned Photo-Diode Capacitance of CMOS Image Sensor in Low illumination Regime
Authors: Suharwerdi Mohsin , Qazi Gausia 
Published: February 2024

Abstract
The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
Shenmai injection in treating chemotherapy-related cardiotoxicity of breast cancer: a systematic review and meta-analysis
Authors: Feng Ming , Huang Hong , Yao Chang 
Published: February 2024

Abstract
Shenmai injection (SMI) is an established treatment for cardiac diseases, and we performed to evaluate the efficacy of SMI combined with chemotherapy drugs for the treatment of chemotherapy-induced cardiotoxicity. The primary outcome was abnormal ECG, LVEF and E/A. The secondary outcomes included myocardial injury biomarkers (CK, CK-MB, and cTnI) and lipid peroxide markers (SOD, GSH, and MAD). Studies indicated that SMI combined with chemotherapy drugs has advantages over chemotherapy drugs alone in reducing the incidence of abnormal ECG (ST-T: RR = 0.613, 95% CI [0.437, 0.862], p = 0.005; extrasystole: RR = 0.527, 95% CI [0.349, 0.798], p = 0.002). Myocardial injury biomarkers in the experimental group were lower than those in the control group (CK: SMD = − 2.614, 95% CI [–3.156, − 2.071], p = 0.000; CK-MB: SMD = − 6.882, 95% CI [–8.982, − 4.782], p = 0.000; cTnI: SMD = − 3.610, 95% CI [–4.949, − 2.271], p = 0.000). Ultrasonic cardiogram analysis showed that the experimental group had a higher LVEF and E/A than the control group (LVEF: SMD = 1.572, 95% CI [1.176, 1.969], p = 0.000; E/A: SMD = 0.280, 95% CI [0.153, 0.407], p = 0.000). Lipid peroxide meta-analysis showed that the experimental group had higher SOD and GSH levels (SOD: WMD = 39.783, 95% CI (32.524, 47.042), p = 0.000; GSH: WMD = 32.960, 95% CI [26.055, 39.865], p = 0.000), and lower MDA (WMD = − 4.962, 95% CI [–6.041, − 3.883], p = 0.000). SMI is effective in reducing cardiac injury and the incidence of cardiotoxicity.
The minimal geoengineering problem concerning the Paris 2015 agreement
Authors: Bodai Tamas , Lembo Valerio , Aneesh Sundaresan , Lee Sun-Seon , Ishuzu Miho , Franz Matthias O. 
Published: February 2024

Abstract

There is a palpable shift in mainstream attitude towards geoengineering technologies, seen now as potential parts of a climate policy mix. Still, concerning solar radiation management (SRM) in particular, because of the known and unknown undesirable side-effects of various engineering implementations of theirs, it is important to know what is the minimal intervention that can achieve a certain goal. Such questions lead mathematically to inverse problems. Solving them is feasible only with lightweight models of the climate system, various types of which are nowadays often referred to as emulators – some more accurate than others. Here we develop an emulator using linear and nonlinear response theory and apply it to the minimal SRM problem concerning the Paris 2015 climate agreement, say, with the aim of constraining the global mean surface temperature below a certain limit. Our results suggest that SRM geoengineering, most commonly envisaged as sulfate aerosol injection, will likely have to be part of our climate policy mix, because realistic CO2 abatement effort to come alone cannot restrict global temperatures below the coveted 1.5 ◦C change or below even higher levels of change. Minimal sulfate use for the 1.5 ◦C limit is very likely to dictate immediate and rather abrupt deployment. However, SRM would be no use to achieve such a goal if the geoengineeringfree “asymptotic” temperature is not below the target limit, as it would then need – in the absence of CDR – maintaining SRM “indefinitely”. The latter could be the case even if the temperature response to an anthropogenic CO2 emission pulse is nonmonotonic, and it would be certainly the case if it is monotonic. We show that the model that we use is near the boundary in parameter space between monotonic and nonmonotoninc temperature responses. In the unfortunate case of monotonicity concerning the real Earth system, the only use of SRM would be “buying time” to develop CDR.
Inhibition of autotrophic nitrifiers in soil by elevated CO2
Authors: Cheng Lei , Zhang Kaihang , Lei Weilei , Zhang Huixin , Xu Chenchao , Xiao Jing , Li Shuyao , Liang Maojun , He Junpan , Lai Yancen , Li Ruiyang , Dong Jiahua , Jiang Mingkai , Zhu Jianguo , Hu Shui-jin , Koide Roger , Firestone Mary 
Published: February 2024

Abstract

Autotrophic nitrifiers, by catalyzing the oxidation of ammonia to nitrate, play a vital role in the global nitrogen cycle 1–5. They convert carbon dioxide (CO2) into biomass 1,3,6 and, therefore, are expected to respond positively to increasing atmospheric CO2 concentrations 1,3,6. However, in a long-term free-air CO2 enrichment experiment, we demonstrated that elevated atmospheric CO2 inhibited the growth of autotrophic nitrifiers, resulting in a reduction in nitrification in a rice ecosystem. By coupling stable isotope probing with metagenomics, we found that the CO2 inhibition of nitrifiers was mainly a consequence of CO2-induced functional loss (that is, incapable of recovering genomes) of dominant but previously uncharacterized autotrophic nitrifying species, especially those of ammonia-oxidizing archaea and nitrite-oxidizing bacteria, which comprised 63% of total dominant members identified from the active nitrifying communities. We further found that the loss of these novel nitrifying species under elevated CO2 was due largely to the CO2-induced aggravation of anoxic stress in the paddy soil. Our results provide insight into the fate of inorganic nitrogen pools in global lowland soil and water systems under future climate change scenarios.
Estimating canopy cover using a Spatially Balanced Sampling approach: A case study of miombo woodlands in Western Tanzania
Authors: Nkya Siwa E. , Shirima Deo D. , Hedenas Henrik , Temu August B. 
Published: February 2024

Abstract

Long-term monitoring is essential to understand the impacts of land use and climate change on miombo woodlands. This study introduces an innovative monitoring design for miombo woodlands with a two-stage sampling utilizing spatially balanced techniques to estimate the area and canopy cover of miombo woodland across the Tabora, Sikonge, Mlele, and Tanganyika districts. The first step involved the selection of 68 tracts, each comprising an average of 1025 plots, with the aid of spatially balanced sampling. Each of the 69,716 plots was classified into closed (canopy cover > 70%), open (40% ≤ canopy cover ≤ 70%), very open (10% ≤ canopy cover < 40%), and non-miombo (canopy cover < 10%) based on woodland cover derived from Sentinel 2 images, followed by the second step consisting of stratified random sampling and inventorying of 2,690 plots within 68 tracts. Using PlanetScope images, we determined the canopy cover for the 2,690 plots selected in the second step and reclassified them accordingly. Employing the Horvitz–Thompson estimator, our results showed that miombo woodlands in these districts cover 37,359 ± 4,618 km² with an average canopy cover of 55% ± 5%. Closed miombo woodland (canopy cover > 70%) was the dominating woodland type, covering 29,546 ± 4,382 km² of the study area with an average canopy cover of 84% ± 7%. The study's innovative sampling design provides reliable estimates of the area of miombo woodlands and average canopy cover, with relative standard errors consistently below 25%, offering a robust foundation for monitoring different miombo types.
Emergent Constraint on Future Changes in the Tropical Atmospheric Circulation
Authors: Madakumbura Gavin D. , Norris Jesse , Thackeray Chad , Po-Chedley Stephen , Ahmed Fiaz , Hall Alex 
Published: February 2024

Abstract

Intensification of the hydrological cycle manifests through a global increase in precipitation at a rate lower than the increase in water vapor, and a consequent weakening in the atmospheric tropical overturning circulation (ATOC). This circulation change shapes future precipitation patterns, but is highly uncertain across Earth System Models (ESMs), complicating efforts seeking to constrain projected changes in regional precipitation. Using two ESM ensembles, we present an emergent relationship between the ATOC’s response to anthropogenic warming, and the ATOC’s variability associated with interannual temperature anomalies. Models simulating the largest future ATOC weakening per degree warming also tend to simulate the largest weakening in association with an internally-generated warm anomaly. Observational estimates of ATOC sensitivity suggest that future ATOC weakening due to climate change is likely larger than expected from a simple multimodel mean (from -1.41±1.06 %/K to -2.20±0.93 %/K). Lastly, we show how this enhanced ATOC weakening impacts regional precipitation patterns. These constrained circulation and precipitation estimates provide a better understanding of how tropical hydroclimate will respond to future warming and associated regional climate impacts.
Identification of a novel diagnostic biomarker for osteoarthritis associated with chromatin regulators and its association with immune cell infiltration
Authors: Zhang Bin , Zhang Zhiwei , Guo Runsheng , Wang Song , Zhu Meisong , Mo Fengbo , Wu Binkang , Dai Min , Liu Xuqiang , Zhan Haibo 
Published: February 2024

Abstract

Background: Osteoarthritis (OA) is considered to be a common chronic degenerative joint disease characterized by cartilage destruction and extracellular matrix degeneration. However, its specific pathogenesis is still unclear. This study aimed to find a novel diagnostic biomarker for osteoarthritis associated with chromatin regulators (CRs) and analyze possible associations between signature genes and immune cell infiltration.
Methods: OA datasets were downloaded from the Gene Expression Omnibus (GEO) database and integrated them with the CRs dataset to create a new dataset. Differentially expressed genes (DEGs) associated with CRs were obtained by differential expression analysis, and functional enrichment analysis of these genes was performed. The CRs-related hub genes were further identified by protein-protein interaction (PPI) analysis. The infiltration level of immune cells in OA was analyzed by Single-sample GSEA (ssGSEA) to explore the correlation between the expression level of hub genes and immune infiltration, and the potential targeted therapeutic drugs of hub genes were predicted by Drug SIGnatures DataBase (DSigDB). Hub genes were used to construct OA diagnostic risk model, identify OA diagnostic biomarkers, and verify its diagnostic value by ROC curve and correction curve. Finally, signature genes were validated in vitro and in vivo by quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blotting (WB), and mouse models of destabilization of the medial meniscus (DMM).
Results: A total of 86 CRs-related DEGs were obtained. These DEGs were enriched in the histone binding and modification, cell cycle, and FoxO signaling pathways. After PPI analysis, we obtained 10 CRs-related hub genes, and finally determined Aurora kinase B (AURKB) as a diagnostic biomarker for OA by constructing a OA risk prediction model. In mouse DMM models and IL-β-induced chondrocytes, qRT-PCR and WB results showed significantly high expression of AURKB in diseased joints and cells. Moreover, ssGSEA analysis showed that there were significant differences in the infiltration levels of 11 immune cells and 12 immune infiltrating functions in the OA samples. Infiltration analysis of immune cells showed that AURKB expression was positively correlated with tumor infiltrating lymphocyte (TIL), Th1 cells, T cell co-inhibition and check-point. Finally, based on the obtained 10 CRs-related hub genes, we found that dasatinib, enterolactone and genistein may be potential targeted therapies for OA.
Conclusion: Overall, our study shows that AURKB is an important biomarker in the development and progression of OA and is significantly correlated with immune infiltration, providing a new way to explore the pathogenesis of OA.
Subnational Persistence of State History: Evidence from Geolocalized Civilizations
Authors: Cook C. Justin 
Published: February 2024

Abstract

This paper uses a novel data set that geolocalizes civilizations across the globe and human history. The data document roughly 1,450 civilizations over 500 time-periods. I spatially and temporally aggregate the civilizations to pre-defined grid-cells to show accumulated civilization years are statistically linked to contemporary nighttime lights and population. The data allow for di↵ering historical cuto↵s to examine deeper and more proximate mechanisms of state history. Estimates illustrate di↵ering roles for state history between the New World, where colonial settlement patterns describe the spatial distribution of people and output, and the Old World, where longer settled areas are tied to better institutional quality.
JEL-Classification: O11, O43, N10, R12
Sleep quality and related predictors among women in the first trimester of pregnancy: A latent profile analysis
Authors: Liu Siqi , Tan Yingyao , Cai Shu , Wang Lixia , Qin Meijiao 
Published: February 2024

Abstract

Background: This study identifies latent profiles of sleep in the first trimester of pregnancy using a person-centered method, and investigate the predictive role of demographics, perinatal features, physical activity, depression, and social capital across profiles.
Methods: A total number of 1,066 pregnant women in Shenzhen were invited to participate in this study. Latent profile analysis (LPA) was used to identify sleep profiles. Regression Mixture Modeling (RMM) was used to explore the predictive role of demographic variables, clinical features, physical activity, depression, and social capital among sleep profiles.
Results: Three profiles were identified:(1) good sleep quality (n = 732, 68.7%), (2) poor sleep efficiency (n = 87, 8.2%), (3) daily disturbances (n = 247, 23.2%). Age, education, occupation, gravidity, childbirth, pregnancy BMI, depression, and social capital were the predictive factors among sleep profiles. Compared with good sleep quality group, pregnant woman in poor sleep efficiency group were more likely to be younger, have education of high school or technical secondary school and undergraduate or above, and higher level of depression, but less likely to have twice pregnancy and one childbirth. Those in daily disturbances group were more likely to be older, obesity and have lower lever of social capital, but less likely to be worker and public servant.
Conclusion: This study revealed three sleep profiles using a person-centered method and underlined the predictive role of depression and social capital across profiles. Our results may provide information for tailored interventions that can promote sleep quality of pregnant women and prevent a worsened sleep quality unprecedented situation.