bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of positional isomerism of cyano group of the rod-like mesogens on the liquid crystalline and optical characteristics
Authors: Liu Zhigao , Liu Xiaotong , Liang Yurun , Zhang Shunbo , Hu Xiuning , Xiao Yulong 
Published: March 2024

Abstract
Two novel cyanostilbene-based rod-like mesogens named BI-CN-4 and BI-CHO-4 consisting of one terminal pyrene and one terminal alkyl chain were prepared by Suzuki coupling and Knoevenagel reactions. The influence of the positional isomerism of cyano group of cyanostilbene unit on the liquid crystalline characteristics, photophysical characteristics, and mechanochromism characteristics is explored by using POM, DSC, XRD, UV spectra, PL spectra, DFT and TD-DFT calculations. BI-CN-4 in which the cyano group is adjacent to the phenylpyrene unit exhibits monotropic smectic C phase, whereas BI-CHO-4 in which the cyano group is far away from the phenylpyrene unit exhibits enantiotropic smectic C phase. BI-CN-4 exhibits more distinct positive solvatochromism due to more distinct intramolecular charge transfer. Both compounds exhibit AIE or AIEE behavior and reversible mechanochromism behavior due to twisted molecular configurations. These results demonstrated that the distinct molecular design could endow organic molecules with multifunctional properties and potentials.
Impact of Interpregnancy Interval after Caesarean Section on Perinatal Outcomes in Multiparous Women of Advanced Maternal Age: A Retrospective Cohort Study
Authors: zhou shengping , dai li , Xu Qin , Ye Lei , wang qilin , Zhou Rong 
Published: March 2024

Abstract

Background: This study aims to evaluate the impact of different interpregnancy intervals (IPIs) after a previous caesarean section on perinatal events in elderly multiparous women.
Methods: In this retrospective cohort study, multiparous women of advanced maternal age who had a previous caesarean section between January 1, 2016, and December 31, 2016, were included.IPI was defined as the duration between live birth and subsequent conception.Multivariate logistic regression analysis was used to assess the association between variant IPIs (<24 months, 60-119 months, and ≥120 months) and perinatal outcomes, with an IPI of 24-59 months as the reference group.The risks of anemia, gestational hypertension, gestational diabetes mellitus,placenta previa,premature rupture of membrane,uterine rupture and successful vaginal were compared among the 4 groups.
Results: We recorded a total of 591 births following cesarean delivery: 16, 89, 290, and 196 births in the IPI < 24 months, 24-59 months, 60-119 months, and ≥120 months groups, respectively. Women with an IPI of ≥120 months had a significantly higher incidence of gestational hypertension (6.1%, p＜0.001) than the other three groups. In women with a prior caesarean delivery and an IPI＜ 24 months, there was an increased risk of incomplete uterine rupture (OR 1.89, 95% CI 1.13-1.87) and low 1-minute Apgar scores (OR 1.55, 95% CI 0.45-4.63). The IPI did not impact the occurrence of incomplete uterine rupture in women with a history of emergency caesarean section.There was no significant association between the IPI and other adverse perinatal outcomes, such as anaemia, gestational diabetes mellitus,abnormal placental position, pernicious placenta, placenta accreta, placental abruption, postpartum haemorrhage, hysterectomy, or neonatal intensive care admission.An IPI <24 months was associated with higher likelihood of premature rupture (OR 1.97, 95%CI 0.58-10.2).
Conclusion: Women with an IPI of ≥120 months had a higher rate of gestational hypertension compared to the other groups, while an IPI of <24 months increased the risk of incomplete uterine rupture and low 1-minute Apgar scores.
Examining Social Support Buffering in a Serial Mediation Model relating Stress to Depressive Symptoms
Authors: Tan Felicia , Rachel Jing Min Ong , Kee Jin Lin , Lim Xin Ying , Long Shenice , Rane Nikita , Lu Sharon Huixian , Hashim Nawal , Chen Helen , Meaney Michael , Tan Geoffrey Chern-Yee 
Published: March 2024

Abstract

A body of evidence supports the role of social support as a buffer against stress in the development of depressive symptoms. However, there are several conceptualisations and measures of stress and their relationships to depression and social support are complex. Here, we tested a serial mediation model between measures of stress and depressive symptoms in 94 university students (Study 1) and 335 mothers from a longitudinal cohort (Study 2). In both cohorts, significant serial mediation effects are observed, linking the number and impact of negative life events, current distress, recent perceived stress, and depressive symptoms. Social support buffered the development of depressive symptoms in response to perceived stress and not at other points in the mediation model. In Study 1, we found a significant moderating effect of perceived social support from friends and significant others, on the relationship between recent perceived stress and depressive symptoms. In Study 2, perceived social support from family and significant others moderated the link between perceived stress and depressive symptoms, and the stress from positive life events was also buffered by social support. By delineating the buffering role of social support against perceived stress, we hope our findings can inform social interventions for mental health.
Comprehensive 4D-QSAR Analysis for Predicting the Biological Activity of Quinazoline: Integrating Electron Conformational and Genetic Algorithm Approaches through a Unified Framework to Uncover Essential Pharmacophoric Features
Authors: Şahin Kader , Sarıpınar Emin 
Published: March 2024

Abstract
To unravel the intricate connection between the molecular structure and bioactivity within a series of quinazolines, our investigation adopted a synergistic methodology that employed a genetic algorithm (GA) in tandem with four-dimensional quantitative structure-activity relationship (4D-QSAR) modeling. Rather than relying on a singular conformation, our model construction represented each compound with a set of conformers. The geometric and electronic structure attributes for every atom and bond in each molecule were computed and organized into an electron–conformational matrix of contiguity (ECMC). The electron conformational submatrix of activity (ECSA) was derived through a comparative analysis of these matrices. For the series of quinazolines, we developed a pharmacophore model based on chemical properties utilizing the EMRE software package. Employing a genetic algorithm, we identified crucial variables to predict theoretical activity. The training set, consisting of 41 compounds, was used to develop 4D-QSAR models, and their predictive capacity was evaluated by including an additional 20 compounds in the test set. The model, incorporating the top twelve parameters, exhibited satisfactory performance. To further scrutinize the contribution of each descriptor to biological activity within the EC–GA model, the E statistics technique was applied.
Design of CMOS 45nm SAR ADC for ECG Signal Applications
Authors: Pradeep Jinka , Ramashri Tirumala 
Published: March 2024

Abstract

Efficient SAR ADCs are necessary for acquiring biomedical signals. The research highlights the use of an 8-bit CMOS 45nm SAR-ADC to capture bio-signals. A suggestion is put forward in the study to incorporate a DAC to improve energy efficiency at the nanowatt level. This approach allows for comparisons to be made with zero energy consumption, resulting in a significant improvement in energy utilization. Research indicates that optimizing the comparator can be achieved by adjusting transistor sizes, eliminating the need for specific offset cancelling methods. The 45nm CMOS technological node is effectively utilized in implementing the SAR-ADC architecture. The ADC achieves an SFDR of 64.12 dB with a power consumption of 1.89uW, operating at a sampling frequency of 1.1MHz and a voltage supply of 1V.
A 6th-Order Current-Mirror-Based Gm-C Bandpass Filter with the Binary Searching Calibration Scheme for Capacitor Sensing Applications
Authors: Chen Hsin-Liang , Chou Hsiao-Hsing , Fu Chun-Kai , Chiang Jen-Shiun 
Published: March 2024

Abstract
This paper presents the current-mirror-based Gm-C bandpass filter with a digitally binary searching calibration scheme. The current-mirror-based circuit technique can be a highly regular structure, which drives the proposed filter to implement the conceptions of the modularized unit and repeatable layout. Furthermore, it employs a tunable bias current circuit and a successively counting logic to implement the binary searching calibration scheme to reduce the mass test timing budget and to obtain the correct frequency response. Thus, the proposed 6th-order current-mirror-based Gm-C bandpass filter can overcome the PVT variations with this automatically tunable bias scheme. Accordingly, a Gm-C LC oscillator, which forms the same unit cell as the filter, generates the oscillated clock for this digital successively counting calibration scheme. This work is designed and implemented in the 0.18μm CMOS process with a supply voltage of 1.8V. The specifications include the center frequency of 200kHz and bandwidth of 100kHz for capacitor sensing applications. The measured power dissipations of the filter and calibrating scheme are 0.65mW and 0.56mW, respectively. After calibrating, the mean offset and standard deviation ratios to the calibrated clock frequency are only 2.1% and 1.66%, respectively.
THE ILLUSIVE WORLD OF SOCIAL MEDIA
Authors: Shreya Biswas  
Published: March 2024

Social media has become an inextricable part of our lives. There’s no denying the fact that the social media has myriad positives but this paper majorly focuses on not so greener side of the dazzling world of perfection which is limned in social media over and over again. The paper starts with a comprehensive definition of social media then goes on to reflect upon various taxing facets that come along. Social media has set unrealistic standards of fashion, beauty, appearance, food, education which gets inculcated in the minds of billions of users and then comes the mad rush to conform to those benchmarks. Social media has provided a thriving market to innumerable beauty brands. FOMO or Fear of Missing Out is another by-product of social media. A deep sense of unhappiness, anxiety, reduced productivity and lower self-esteem is often associated with it. Users may have millions of subscribers and followers but this virtual fan following donot always mirrors their offline life. Social media has uncannily conned us in believing that we have friends while in reality this is just the contrary. Besides, the spread of fake news , trolling, cyber bullying , hate speech and increasing cases of people getting duped by the fraudsters are other pitfalls of social media. It finally rests with the users how to use this double edged sword. These platforms can either be used for disseminating obscenity, hatred, or rumours else can be utilitized to the fullest for enhanced networking, fostering support and empathy and even as a learning tool.
FOOTPRINTS OF FINTECH ON FINANCIAL INCLUSION – EVIDENCE FROM DIGITAL BANKING SYSTEM
Authors: Khushboo Patel  , Dr. Shashi Kashyap  , Dr. R. P. Agrawal  
Published: March 2024

Fintech is considered as the vehicle of financial Inclusion. The research paper attempts to explain the impact of fintech on financial inclusion through various types of digital banking activities. The research paper mainly focuses to analyse the growth of digital banking activities with the help of fintech to achieve complete financial inclusion. India has also witnessed the miracle of fintech in the field of banking & finance sector (Prateek Roongta, and Karthik Raghupathy n.d.). Complete financial inclusion is a step towards developing a cashless economy. With the help of fintech services and fintech software people conducting their daily activities related to money is now a piece of cake. Hence, the paper is attempted to analyse the growth in digital banking with the help of financial technology. This study also analyses the measurements of currency, the enablers for payment systems, and the measures of electronic payments. The paper studies the measures of cash, electronic payments, and the enablers for payment systems, over the last 5 years. To ascertain the changes in India, if any, from cash to digital payments. It has discussed the enormous opportunities that recent financial innovations offer, but also the risks that might come from them.
Sensitivity of bias correction step on generating hydrological scenarios
Authors: Guilpart Étienne , Espanmanesh Vahid , Tilmant Amaury , Bourgault Marc-André 
Published: March 2024

ABSTRACT
Significant shifts in hydro-climatic regimes are expected in many parts of the world during the 21st century, affecting the water cycle. Vulnerability, impact, and adaptation studies often use tailored modeling chains to assess the expected effects of climate change, but the robustness of these chains is rarely investigated. This highlights the need for more rigorous evaluation of modeling chains to ensure that they are reliable for informed decision-making processes. To address this gap, we propose a framework for evaluating the sensitivity of hydrological scenario production to the bias correction step. We apply the framework to the Senegal River Basin, using three bias correction methods (linear scale, empirical quantile mapping, and nested bias correction) and three procedures (climate-correction, hydrological-correction, and climate-hydrological-correction). Our results show that the choice of modeling chain has a significant impact on future hydro-climatic trajectories. In particular, the combination of climate-and-hydrological-correction procedures may be optimal when both climate biases and hydrological model errors are significant. Moreover, using multiple bias correction methods can strengthen the ensemble of future hydro-climatic conditions. These findings have implications for vulnerability–impact–adaptation studies and underscore the importance of rigorous modeling chain design and sensitivity analysis.
Evaluating the impacts of anthropogenic, climate, and land use changes on streamflow
Authors: Ruigar Hossein , Emamgholizadeh Samad , Gharechelou Saeid , Golian Saeed 
Published: March 2024

ABSTRACT
Several factors, including natural and human-induced, can affect river discharge. This study aims to examine the influence of land use changes and climate change on the monthly average streamflow time series in the Talar River basin, in northern Iran. To investigate the impact of human factors, namely land use change and point source operations, on monthly average streamflow, the DBEST method was used to detect any breakpoint in the streamflow time series caused by gradual changes in land use and climate. The SWAT model was used to simulate the basin at Kiakola and Shirghah stations, between 2001 and 2020. The land use maps were created for the years 2001 and 2019. Calibration and validation at the Kiakola station showed that the Nash-Sutcliffe model (NSE) had an efficiency of 0.8 and 0.76, respectively, while at the Shirghah station, the same values were 0.84 and 0.75. Findings revealed that human activities, specifically the combined impact of land use change and point source operations, had a 60% influence on the monthly average streamflow of the Talar River. They further showed that the combination of land use and harvesting played the most significant role in the basin's outflow on a monthly scale.
Actinomycetes - The Repertoire of Diverse Bioactive Chemical Molecules: From Structures to Antibiotics
Authors: Baba Ishfaq Ahmad , Wani Zubair Ahmad , Ali Shazia , Ahmad Zahoor , Mubarak Mohamad Mosa 
Published: March 2024

Abstract:
The urgent need for novel antibiotics in the face of escalating global antimicrobial resistance
necessitates innovative approaches to identify bioactive compounds. Actinomycetes,
renowned for their prolific production of antimicrobial agents, stand as a cornerstone in this pursuit.
Their diverse metabolites exhibit multifaceted bioactivities, including potent antituberculosis,
anticancer, immunomodulatory, immuno-protective, antidiabetic, etc. Though terrestrial sources
have been exploited significantly, contemporary developments in the field of antimicrobial drug
discovery have put marine actinomycetes in a prominent light as a promising and relatively unexplored
source of novel bioactive molecules. This is further boosted by post-genomic era advances
like bioinformatics-based secretome analysis and reverse engineering that have totally revitalized
actinomycetes antibiotic research. This review highlights actinomycetes-based chemically diverse
scaffolds and clinically validated antibiotics along with the enduring significance of actinomycetes
from untouched ecosystems, especially with recent advanced techniques in the quest for
next-generation antimicrobials.
Pathobiology of Pulmonary Arterial Hypertension
Authors: Lewis Michael , Voelkel Norbert , Kadri Ferdous 
Published: March 2024

Abstract:
Pulmonary Arterial Hypertension (PAH) is a progressive disease associated with occlusive
pulmonary arterial remodeling of vessels < 500 μm for which there is no cure. Even in the
era of PAH-specific combination therapies, aberrant lung pathology and progressive right ventricular
(RV) dysfunction occur, culminating in a median survival of 6.2 years, according to the latest
data in the treatment era. While better than a median survival from symptom onset of 2.8 years prior
to PAH-specific therapies, it is still poor. Thus, there is an urgent need to move the opportunities
forward for meaningful treatment strategies. Clearly, a better understanding of the highly complex
pathobiology of PAH is needed if we are to achieve new and novel treatment strategies. This
is especially so if we are to pursue a more personalized treatment approach to PAH in light of the
multitude of pathobiological abnormalities described in PAH, which likely culminate in a final
common pathway for PAH development.

:
In this State-of-the-Art review, we provide comprehensive insights into the complex pathobiology
of PAH to provide understanding and insights for the practicing clinician. We review the pathology
of PAH and the cells involved and their impact in driving pathological abnormalities (pulmonary
artery endothelial cells, smooth muscle cells, fibroblasts and pericytes) as well as the role of
the extracellular matrix. Inflammation and immune dysfunction are considered important drivers
of PAH and are comprehensively discussed. Another pathway relates to TGFβ/ bone morphogenic
protein (BMP) imbalance, which is highlighted, as well as a new novel agent, sotatercept that impacts
this imbalance. Genetic factors underlying heritable PAH (HPAH) are addressed, as well as
epigenetic influences. Other important pathways highlighted include growth factor signaling, ion
channels/channelopathy, hypoxia signaling pathways, and altered metabolism and mitochondrial
dysfunction. We also address the “estrogen paradox”, whereby PAH is more common in women
but more severe in men. The basis for drug-induced PAH is discussed, including the new methamphetamine
epidemic. We briefly provide insights into DNA damage and senescence factors in
pathobiology and highlight commonalities between PAH and cancer pathobiology. Furthermore,
we provide concluding insights for the treating physician. In conclusion, we need to pose the right
questions to motivate novel and effective treatment strategies for the management of PAH based
on pathobiological principles and understanding.
Water Nutriture: Essential but Misunderstood
Authors: Vavilala Pratyusha , Narayanasamy Nandita 
Published: March 2024

:
In their search for life, space scientists are looking for traces of water on other planets
in the solar system because of the well accepted knowledge that water is important for all living
systems. Water makes up 60-75% of human body weight. A loss of just 4% of total body water
can lead to severe dehydration, and a loss of 15% is fatal. What makes water so essential for survival?
Though life on earth is described as a carbon-based phenomenon, it would not be amiss to also
call it a water-based phenomenon, as water is the universal solvent that dissolves all biological
molecules. Despite this deep understanding of both the chemistry and the biochemical importance
of water in human physiology, questions still remain regarding what is the required consumption
of water? What type of water is to be ingested? In the context of Nutrition, water is not only an essential
nutrient but is also an important source of antinutrients and toxins. Another question that remains
ambiguous is: How much water is essential? If it is a nutrient, does it have an RDA? Can
one suffer and die from water intoxication? This review puts together in simple terms what one
needs to know about water as an essential nutrient in our diet.
Percutaneous Patent Foramen Ovale Closure: Stroke and Beyond
Authors: Randhawa Sandeep , Mehta Jawahar L. , Dhar Gaurav 
Published: March 2024

Abstract:
Over 750,000 individuals suffer from stroke annually in the United States, with 87%
of these strokes being ischemic in nature. Roughly 40% of ischemic strokes occur in individuals
60 years of age or under. A quarter of all ischemic strokes have no identifiable cause despite
extensive workup and are deemed cryptogenic in nature. Patent Foramen Ovales (PFO)
has been postulated in stroke causation by either paradoxical embolization or platelet activation
in the tunnel of the defect. The incidence of PFO is reported to be 15-25% in the general population
but rises to 40% in patients with cryptogenic stroke. While the initial trials evaluating
PFO closures were non-revealing, subsequent long-term follow-ups, as well as recent trials
evaluating PFO closures in cryptogenic stroke patients 60 years of age or under, demonstrated
the superiority of percutaneous closure compared to medical therapy alone, leading to FDA
approval of PFO closure devices. In this review, we review the diagnosis of PFO, postulated
stroke mechanisms, literature supporting PFO closure, patient selection for percutaneous closure,
procedural considerations, and associated procedural complications.