bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of Patients with Decreased Bone Density Aged Over 50 Years Old with Cases of Femoral Neck Fracture, Thoracic Vertebral Compression Fracture, Lumbar Vertebral Compression Fracture, and Distal Radius Fracture in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2019-2020
Authors: Pratama Arlingga , Sari Gadis Meinar , Utomo Dwikora Novembri 
Published: February 2025

Highlights:

Decreased bone density often progresses to osteoporosis, where osteoporosis is a degenerative disease characterized by low bone mass, bone tissue damage, and bone microarchitecture disorders that can lead to an increased risk of bone fracture.

Fractures often found in low bone density consist of fractures of the femoral neck, the thoracic and lumbar vertebrae, and distal radius fractures.

Abstract
Introduction: Human life expectancy will increase over time, as will various chronic degenerative diseases, one of which is fracture caused by decreased bone mass density. This study described fracture features associated with decreased bone mass density in patients over 50 years old.
Methods: This study took place at the Polyclinic of Orthopaedics and Traumatology Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, using a quantitative design with a cross-sectional approach. The sample in this study consisted of 56 medical records collected using a questionnaire processed with Microsoft Excel.
Results: This study used 56 samples. Femoral neck fractures had the highest number of decreased bone mass density fractures (69.7%). The most common body mass index (BMI) found with fractures was obese patients (32.2%). Most fractures were experienced by females (64.3%). The location of the highest incidence of fractures was found in domestic accidents (66.1%) with low-energy trauma (67.9%).
Conclusion: Most of the fractures caused by decreased bone density in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, were femoral neck fractures, with females being the most common gender. These fractures were also the most common in obese patients, and the highest incidence was found in domestic accidents with low-energy trauma.
Obesity and Clinical Outcomes of Acute Decompensated Heart Failure
Authors: Nuvus Alviyatul Ainin , Andrianto Andrianto , Mudjanarko Sony Wibisono 
Published: February 2025

Highlights:

Clinical outcomes in obese acute decompensated heart failure patients were found to be better than those of non-obese patients but not statistically significant.

Acute decompensated heart failure patients were dominated by males.

Abstract
Introduction: Obesity is an independent risk factor that raises the prevalence of heart failure, but it is paradoxically associated with a better prognosis. This study examined the relationship between obesity and clinical outcomes of acute decompensated heart failure at Dr. Soetomo General Academic Hospital, Surabaya.
Methods: This was an analytic observational study using a prospective cohort design. Patients with acute decompensated heart failure who were admitted to the inpatient care unit of Dr. Soetomo General Academic Hospital, Surabaya, from December 2021 to July 2022 were chosen using a purposive sample technique. The data were analyzed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26.0.
Results: There were 58 patients (n=58) representing different categories, with an average age of 55 years old, and were predominately males (58.6%). This study found that clinical outcomes in obese acute decompensated heart failure patients were better than those of non-obese patients in terms of shorter lengths of stay (p=0.825), lower rates of rehospitalization (p=0.458), and lower rates of all-cause mortality (p=0.673).
Conclusion: The difference between the clinical outcomes in obese acute decompensated heart failure patients and non-obese patients was not statistically significant.
PERAN USAHA TERNAK DOMBA TERHADAP KETAHANAN PANGAN RUMAH TANGGA PETERNAK (KASUS DI KECAMATAN KERTAJATI, KABUPATEN MAJALENGKA)
Authors: Putri Nadhilah Rahayu , Kuswaryan Sondi , Firmansyah Cecep 
Published: February 2025

Domba merupakan komoditas usaha ternak yang sering menjadi andalan ekonomi rumah tangga bagi peternak di Jawa Barat. Penelitian ini dilaksanakan di Desa Babakan dan Desa Pasiripis, Kecamatan Kertajati, Kabupaten Majalengka, bertujuan untuk mengetahui sejauhmana tingkat ketahanan pangan rumah tangga peternak dan bagaimana peran dari usaha ternak domba terhadap ketahanan pangan rumah tangga peternak. Penelitian ini menggunakan metode survei dengan responden sebanyak 46 orang dan data pengeluaran rumah tangga didapat melalui proses wawancara dengan reponden dan data konsumsi gizi didapat dengan menggunakan metode food recall 3x24 jam. Hasil penelitian menunjukkan bahwa nilai pangsa pengeluaran rumah tangga peternak adalah sebesar 55,71% dan konsumsi energi sebesar 102,92% yang mengindikasikan ketahanan pangan rumah tangga peternak berada pada kategori tahan pangan. Besarnya kontribusi usaha ternak domba terhadap pemenuhan kebutuhan pangan adalah sebesar 67,79%, artinya usaha ternak domba memiliki peran yang cukup besar dalam memenuhi kebutuhan pangan dan menjaga ketahanan pangan rumah tangga.
Kata Kunci: Analisis pendapatan usaha ternak, ketahanan pangan, peternak domba.
KANDUNGAN FRAKSI SERAT FERMENTASI BATANG PISANG DENGAN PENAMBAHAN INDIGOFERA (Indigofera sp) SEBAGAI PAKAN TERNAK
Authors: Asjanita Laras , Dona Afrini , Elisia Rini 
Published: February 2025

Pakan merupakan kebutuhan utama untuk ternak dikarenakan pakan mengandung zat-zat makanan untuk pertumbuhan dan produktivitas ternak itu sendiri. Keberhasilan suatu usaha peternakan tergantung pada pakan yang digunakan dan dimanfaatkan oleh ternak. Variabel terbesar dari total biaya produksi suatu usaha adalah biaya pakan yang dapat mencapai 70-80%. Menghindari biaya yang tinggi maka perlu dimanfaatkan limbah pertanian sebagai pakan ternak. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan Indigofera terhadap kualitas fraksi serat fermentasi batang pisang. Penelitian ini merupakan penelitian eksperimen menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan empat ulangan. Perlakuan yang diterapkan yaitu: P0= Batang pisang + 0% Indigofera, P1= Batang pisang + 10% Indigofera, P2= Batang pisang + 20% Indigofera, P3= Batang pisang + 30% Indigofera, dan P4= Batang pisang + 40% Indigofera. Parameter yang diukur yaitu kandungan Neutral Detregent Fiber (NDF), Acid Dteregent Fiber(ADF), dan hemiselulosa. Hasil penelitian menunjukkan bahwa penambahan Indigofera terhadap kandungan NDF, ADF, dan hemiselulosa nyata dalam menurunkan kandungan kadar NDF, ADF, dan hemiselulosa batang pisang fermentasi. Kesimpulan dari hasil penelitian adalah penambahan Indigofera sebanyak 40 % menghasilkan kualitas fermentasi batang pisang terbaik.
Potential source of bias in AI models: Lactate measurement in the ICU as a template
Authors: Hussein Nebal S. Abu , Pradhan Pratiksha , Haug Fredrik Willumsen , Moukheiber Dana , Moukheiber Lama , Moukheiber Mira , Moukheiber Sulaiman , Weishaupt Luca Leon , Ellen Jacob G. , D’Couto Helen , Williams Ishan C. , Celi Leo Anthony , Matos João , Struja Tristan 
Published: February 2025

Abstract

Objective: Health inequities may be driven by demographics such as sex, language proficiency, and race-ethnicity. These disparities may manifest through likelihood of testing, which in turn can bias artificial intelligence models. The goal of this study is to evaluate variation in serum lactate measurements in the Intensive Care Unit (ICU).
Methods: Utilizing MIMIC-IV (2008-2019), we identified adults fulfilling sepsis-3 criteria. Exclusion criteria were ICU stay <1-day, unknown race-ethnicity, <18 years of age, and recurrent stays. Employing targeted maximum likelihood estimation analysis, we assessed the likelihood of a lactate measurement on day 1. For patients with a measurement on day 1, we evaluated the predictors of subsequent readings.
Results: We studied 15,601 patients (19.5% racial-ethnic minority, 42.4% female, and 10.0% limited English proficiency). After adjusting for confounders, Black patients had a slightly higher likelihood of receiving a lactate measurement on day 1 (odds ratio 1.19, 95% confidence interval (CI) 1.06-1.34), but not the other minority groups. Subsequent frequency was similar across race-ethnicities, but women had a lower incidence rate ratio (IRR) 0.94 (95% CI 0.90-0.98). Interestingly, patients with elective admission and private insurance also had a higher frequency of repeated serum lactate measurements (IRR 1.70, 95% CI 1.61-1.81, and 1.07, 95% CI, 1.02-1.12, respectively).
Conclusion: We found no disparities in the likelihood of a lactate measurement among patients with sepsis across demographics, except for a small increase for Black patients, and a reduced frequency for women. Variation in biomarker monitoring can be a source of data bias when modeling patient outcomes, and thus should be accounted for in every analysis.
Radiolabeled dendrimer non-invasively tracks innate immune activation in multiple sclerosis mice after immunomodulatory therapy
Authors: James Michelle , Kuo Renesmee , Carlson Mackenzie , Reyes Samantha , Nagy Sydney , Kalita Mausam , Alam Israt , Malik Noeen , Jackson Isaac , Acosta Christopher , Falk Irene , Azvedo Carmen , Zhang Yanrong , Nichols Lisa , Beinat Corinne , Avci Naze , Minami S. Sakura , Cleland Jeffrey 
Published: February 2025

Abstract

Multiple sclerosis (MS) is a chronic neurodegenerative disease driven by immune cell infiltration into the central nervous system (CNS). Despite the critical role of immune cells in MS initiation and progression, current standard of care imaging techniques rely on structural lesion assessments, often resulting in misdiagnoses and inaccurate disease staging. Here we describe a novel dendrimer positron emission tomography (PET) tracer, 18F-flurimedrimer (18F-FMD), for non-invasive detection and tracking of activated myeloid cells–key immune players in MS. Using an experimental autoimmune encephalomyelitis (EAE) murine model of MS, we demonstrate the ability of 18F-FMD to specifically detect these cells at both presymptomatic and symptomatic stages, with signal intensity correlating with disease severity. We illustrate that 18F-FMD can also accurately monitor the immunomodulatory effects of Food and Drug Administration (FDA)-approved disease-modifying MS drug fingolimod (FTY720) and a novel CSF1R dendranib (H74DS3M8), both of which reduced immune cell activation and halted disease progression. These findings highlight the potential of 18F-FMD PET for early MS diagnosis and as a generalizable approach for real-time monitoring of therapeutic responses across various mechanisms. Since we have translated 18F-FMD for clinical imaging, it has the potential to revolutionize patient stratification in clinical trials and optimize treatments, making precision medicine a reality for MS patients.
Neighborhood Disadvantage, Peer Acceptance, and Sense of Belonging among Middle School Students
Authors: Duran Naomi S. , Lleras Christy L. 
Published: February 2025

Abstract

Prior studies have demonstrated how living in economically disadvantaged and dangerous neighborhoods is associated with poorer developmental outcomes including depressed academic achievement, poorer physical and mental health, and lower school engagement. At the same time, studies have shown peer acceptance and school belonging are closely connected such that when youth feel more accepted by their classmates, they feel happier and more secure and exhibit greater academic motivation and classroom engagement. Our study builds on these prior bodies of work by examining how neighborhood disadvantage and peer relationships in the classroom influence students’ sense of belonging in middle school. This study utilized data from the last wave of the Early Childhood Longitudinal Study – Kindergarten Cohort (1998-1999) when students were in eighth grade combined with tract-level data from the 2000 Census to conduct multilevel regression analyses. The findings suggest youth living in more structurally disadvantaged neighborhoods reported lower school belonging at the end of eighth grade. Consistent with prior studies, we also found youth who felt more accepted by their peers had a greater sense of school belonging, regardless of the kinds of neighborhoods, schools and families they were living in suggesting that peer acceptance may play a powerful role in creating school attachment during adolescence. The demonstrated impact of peer acceptance on school belonging highlights the importance of fostering opportunities for socialization through school-based programs and extracurriculars which may foster greater school attachment and improve educational attainment.
Bioindustrialization by native people: A systemic management approach to foster coevolution
Authors: Miranda Raizza , Schwaninger Markus , Belderrain Mischel Carmen Neyra , Baniwa André , Nobre Carlos , Carvalho Tereza , Ochoa-Arias Alejandro , Sato Renato , Nobre Ismael , Nobre Paulo 
Published: February 2025

Abstract

This article proposes a systemic management model tailored for biofactories operating within the Amazon rainforest. The model aims to empower indigenous populations by enhancing their control over local development and a sustainable innovation ecosystem. Leveraging the Model of Systemic Control and the Viable System Model, we employed a qualitative methodology based on interviews with key stakeholders, including Indigenous leaders and community representatives, to incorporate local perspectives and values into the proposed redesign. Our analysis of management structures in community-based social enterprises guided the redesign, grounded in the principles of organizational cybernetics. The study was conducted at the Amazon Creative Lab (ACL), a biofactory situated within the Amazon rainforest that serves as a platform for innovative experimentation and capacity building, showcasing the potential of the forest and local communities. By prioritizing cultural appreciation and addressing exclusionary and colonialist practices, the ACL highlights the importance of integrating cultural values and respecting local traditions. The proposed management model enhances organizational self-determination while balancing the interaction between traditional communities and Western perspectives, reinforcing the role of community organizations within their territories.
Revitalizing Tourism in Crisis: The Significance of Domestic Tourism in COVID-19 Recovery and Policy Initiatives in Top Tourist Destinations of the Amhara Region, Ethiopia
Authors: Tegegne Asnakew Atlug , Tadesse Girum Teshome , Melsi Temesgen Fikadie 
Published: February 2025

Abstract

In time of COVID-19 and other crisis, the focus of the tourism industry is to devise and implement strategies for its recovery. This study examined the role of domestic tourism in recuperating from the pandemic, policy initiatives, recovery strategies, and challenges in top tourist destinations in the Amhara Region. The research employed a mixed method approach with a descriptive design, and 384 questionnaires were distributed to respondents selected through convenience sampling, while 15 key informants were purposefully interviewed. The findings revealed that domestic tourism played a significant role in mitigating the impact of the pandemic and building resilient tourism businesses. It was found to be an "incredible crisis absorber" and crucial for rebuilding customer confidence. The study also showed that most features of domestic tourism, such as pilgrimage travel, proximity and ease of access, visiting families and relatives, and the use of road transportation and less standardized hotels, played a significant role in revitalizing the tourism sector. As various policies and recovery strategies have been implemented by governments worldwide, the Amhara Region's Culture and Tourism Bureau developed a two-phase COVID recovery strategy (response and recovery phases) aimed at protecting and supporting tourism activities. Conversely, high costs at destinations, the lack of comprehensive domestic tourism development and marketing strategy, poor infrastructural development, and a mismatch between the services offered and the demands of tourists were found to be major hindrances to the growth of domestic tourism in the region.
Investment Strategies and Corporate Risk-Taking: A BRICS Market Perspective
Authors: Bagh Tanveer , Naseer Mirza Muhammad , Khan Muhammad Asif 
Published: February 2025

Abstract

Corporate governance literature extensively explores the determinants of corporate risk-taking, however consensus on the key motivating factors remains elusive. Addressing this gap, we examine the role of investment efficiency, financial flexibility, and investment scale as drivers of corporate risk-taking in emerging markets, offering insights to help firms make informed high-stakes investment decisions. Using a sample of 4,889 listed firms from BRICS countries (Brazil, Russia, India, China, and South Africa), we analyze three distinct periods: (a) the full sample, (b) the pre-COVID period, and (c) the COVID period. Applying static and dynamic panel estimation techniques, our generalized method of moments, results confirm that financial flexibility, investment efficiency, and investment scale significantly and positively influence corporate risk-taking across all three periods. Furthermore, quantile regression results highlight that these factors exert a stronger influence in the upper and median quantiles of risk-taking. These findings suggest that investment efficiency, financial flexibility, and investment scale serve as enablers that empower firms to undertake calculated risks, seize growth opportunities, and strengthen their market positioning. Robustness checks affirm the stability of our results, and we conclude with key policy implications.
Link between Adenomyosis and Endometrial Cancer
Authors: Sözen Işık , Şahin Gözde , Yassa Mahmut 
Published: February 2025

Abstract

Purpose
Adenomyosis is a noncancerous condition where endometrial tissue is found within the myometrium. Prior uterine surgery, parity, and estrogen exposure are known risk factors. Evidence suggests a connection between adenomyosis and endometrial cancer. This study aimed to examine the association of adenomyosis with endometrial cancer to assess adenomyosis' role as a risk factor for endometrial cancer.
Methods
This study included 189 patients (aged 18–80) diagnosed with endometrial cancer and who underwent surgery at Başakşehir Çam and Sakura City Hospital between May 2020 and August 2022.
Results
Out of the total, 131 cases (69.3%) were diagnosed with adenomyosis, while 58 cases (30.7%) were not. There was no link found between adenomyosis and age (p = 0.17), menopausal status (p = 0.58), parity (p = 0.18), or type of delivery (p = 0.66) and CA-125 level (p = 0.9). BMI showed statistical significance in endometrial cancer patients who also had adenomyosis (p = 0.01)
Conclusion
Endometrial cancer co-occurrence with adenomyosis was linked solely to BMI, not other factors. Findings suggest adenomyosis is not a risk factor for, nor protective against, endometrial cancer.
Multi-Channel Heat Pipe: Experimental Investigation, CFD Analysis, and Theoretical Modeling of Two-Phase Heat Transfer
Authors: Yerne Yogita 
Published: February 2025

Abstract

This is the study of an innovative application of multi-channel heat pipe use for harnessing and reusing wasted heat from engine exhaust. To unravel the intricacies of two-phase heat transfer involving boiling and condensation within multi-channel heat pipes, a distinctive multichannel heat pipe was designed and constructed. Computational Fluid Dynamics (CFD) and theoretical models for the multi-channel heat pipe were developed for a comprehensive understanding. The simulation of multichannel heat pipe operation using ANSYS Fluent employed the Volume of Fluid (VOF) approach and the Lee model. Multiple Lee models, implemented through user-defined functions (UDF), were compared, and the impact of condenser boundary conditions, saturation temperature, and mass transfer coefficient on the simulations was thoroughly examined. This study identifies the significant limitations of the Lee model for heat pipe simulation, exposing its incapability in predicting heat pipe temperatures due to low physical significance and susceptibility to manipulation. A novel theoretical model was formulated for multi-channel heat pipes which were based on experimental data from multichannel heat pipe. This model uses the thermal-electrical resistance analogy to predict the thermal resistance of the multichannel heat pipe. The selection of optimal correlations for pool boiling and film wise condensation, the developed iterative theoretical model achieved 9.2% error in predicting the thermal resistance of multichannel heat pipe. In conclusion, this research sheds light on the intricacies of multi-channel heat pipes and highlights the shortcomings of existing Lee models in simulating heat pipe behavior. The proposed theoretical model, grounded in experimental data, provides a more accurate prediction of thermal resistance, paving the way for improved design and performance of heat pipe applications vapor absorption cooling systems.
MEGB: An R package for Mixed Effect GradientBoosting for High-dimensional Longitudinal Data
Authors: Olaniran Oyebayo Ridwan , Olaniran Saidat Fehintola , Allohibi Jeza , Alharbi Abdulmajeed , Alharbi Nada MohammedSaeed 
Published: February 2025

Abstract

High-dimensional longitudinal data present significant analytical challenges due to intricate within-subject correlations and an overwhelming ratio of predictors to observations. To address these challenges, we introduce Mixed-Effect Gradient Boosting (MEGB), a novel R package that synergizes gradient boosting with mixed-effects modeling to simultaneously account for population-level fixed effects and subject-specific random variability. MEGB provides a unified framework for analyzing repeated measures data that accommodate complex covariance structures while harnessing gradient boosting’s inherent regularization for robust feature selection and prediction. In comprehensive simulations spanning linear and nonlinear data-generating processes, MEGB achieved 35–76% lower mean squared error (MSE) compared to state-of-the-art alternatives like Mixed- Effect Random Forests (MERF) and REEMForest, while maintaining 55–70% true positive rates for variable selection in ultra-high-dimensional regimes (p = 2000). Demonstrating practical utility, we applied MEGB to maternal cell-free plasma RNA data (n = 12 subjects, p = 33,297 transcripts), where it identified 9 key placental transcripts driving fetal RNA dynamics across pregnancy trimesters.