bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrophoretic methods for analysis of urinary polypeptides in IgA‐associated renal diseases
Authors: Julian Bruce A. , Wittke Stefan , Novak Jan , Good David M. , Coon Joshua J. , Kellmann Markus , Zürbig Petra , Schiffer Eric , Haubitz Marion , Moldoveanu Zina , Calcatera Shannon M. , Wyatt Robert J. , Sýkora Josef , Sládková Eva , Hes Ondrej , Mischak Harald , McGuire Brendan M. 
Published: November 2007

AbstractWe evaluated the utility of SDS‐PAGE/Western blot and CE coupled with MS (CE‐MS) for detection of urinary polypeptide biomarkers of renal disease in patients with IgA‐associated glomerulonephritides. In a reference cohort of 402 patients with various renal disorders and 207 healthy controls, we defined CE‐MS patterns of renal damage and IgA nephropathy (IgAN). In a blinded analysis of a separate cohort of patients with IgAN (n = 10), Henoch‐Schoenlein purpura (HSP) with nephritis (n = 10), and IgA‐associated glomerulonephritis due to hepatitis C virus (HCV)‐induced cirrhosis (n = 9), and healthy controls (n = 12), we compared SDS‐PAGE/Western blot and CE‐MS against clinical urinalysis for detection of urinary proteins/polypeptides. Urinalysis indicated proteinuria for 50, 90, and 33% of patients, respectively, and for none of the healthy controls. SDS‐PAGE/Western blot showed urinary polypeptides abnormality for 90, 80, and 67% of patients, respectively, and for none of the healthy controls. CE‐MS indicated a Renal Damage Pattern in 80, 80, and 100 of patients, respectively, and in 17% of healthy controls, with the more specific IgAN Pattern in 90, 90, and 1%, respectively, and in none of the healthy controls. Based on differences in CE‐MS patterns, the disease mechanisms may differ among various IgA‐associated glomerulonephritides. These exploratory findings should be evaluated in a prospective study with contemporaneous renal biopsy and urinary testing. If validated, it may be feasible to adapt the CE‐MS methodology to develop novel tests to detect renal injury at earlier stages, assess clinical manifestations, and monitor responses to therapy in patients with IgA‐associated renal diseases.
Atypical antipsychotics in severe anorexia nervosa in children and adolescents—review and case reports
Authors: Mehler‐Wex Claudia , Romanos Marcel , Kirchheiner Julia , Schulze Ulrike M.E. 
Published: November 2007

AbstractObjectiveTo review the literature on the use of atypical antipsychotics in anorexia nervosa of children and adolescents and to present three case reports on quetiapine treatment of this subgroup.MethodReview of the literature and case report.ResultsSeveral case reports and two small open‐label trials, mainly in adults, observed beneficial effects of olanzapine on anorexic psychopathology. Only 16 case reports have been published on children and adolescents. Because of its lower propensity to induce weight gain quetiapine might be favourable with regard to patients' compliance. Our case reports revealed positive psychopathological effects and good tolerability of quetiapine in minors with severe anorexia nervosa. Careful titration and intense drug monitoring are recommended.DiscussionIn a small subset of patients with severe, treatment‐ resistant anorexia nervosa, extreme weight phobia, delusional body image disturbances or severe hyperactivity might be considered as indications for atypical antipsychotics. However, controlled studies are needed. Copyright © 2007 John Wiley & Sons, Ltd and Eating Disorders Association.
Power transformer top‐oil temperature model based on thermal–electric analogy theory
Authors: Weigen Chen , Chong Pan , Yuxin Yun 
Published: November 2007

AbstractThis paper presents a thermal–electric analogous thermal model of an oil‐immersed power transformer. The model is established to calculate the top‐oil temperature in the form of simple equivalent circuit based on the fundamental heat transfer theory. The presented model takes into account application of the lumped capacitance, nonlinear thermal resistances, and oil viscosity, whereas Levenberg–Marquardt Method is used as a search method to determine the thermal model parameters. For the OFAN and OFAF power transformers, a lot of experimental data and curves show the proposed model in this paper can yield better results than IEEE thermal model and be used widely in the power transformer fault prediction field. Copyright © 2007 John Wiley & Sons, Ltd.
Regression‐based modeling of market option prices: with application to S&P500 options
Authors: Pandher Gurupdesh S. 
Published: November 2007

AbstractThis paper presents a simple empirical approach to modeling and forecasting market option prices using localized option regressions (LOR). LOR projects market option prices over localized regions of their state space and is robust to assumptions regarding the underlying asset dynamics (e.g. log‐normality) and volatility structure. Our empirical study using 3 years of daily S&P500 options shows that LOR yields smaller out‐of‐sample pricing errors (e.g. 32% 1‐day‐out) relative to an efficient benchmark from the literature and produces option prices free of the volatility smile. In addition to being an efficient and robust option‐modeling and valuation tool for large option books, LOR provides a simple‐to‐implement empirical benchmark for evaluating more complex risk‐neutral models.  Copyright © 2007 John Wiley & Sons, Ltd.
Composite Proton‐Conducting Membranes for PEMFCs
Authors: Mustarelli P. , Carollo A. , Grandi S. , Quartarone E. , Tomasi C. , Leonardi S. , Magistris A. 
Published: November 2007

AbstractComposite membranes are of interest for PEMFCs and DMFCs. This paper describes a basic study of the influence of silica on the proton conductivity: (i) added as a filler to poly(vinylidene fluoride‐hexafluoropropylene) and poly(benzimidazole)‐based membranes activated with H3PO4, or (ii) included in the matrix of class II hybrids based on tetraethoxysilane and poly(ethylene glycol) and activated with phosphotungstic acid (PWA).The addition of acidic silica as a filler determines proton conductivity increases up to one order of magnitude for filler amounts which strongly depend on the proton transport mechanism, and on the nature (free or partially free) of the activating acid. The increase of the silica content in the hybrid matrix induces a more complex behaviour which also depends on the amount of PWA.
Case‐finding algorithm for post‐stroke depression in the veterans health administration
Authors: Damush Teresa M. , Jia Huanguang , Ried L. Doug , Qin Haijing , Cameon Randi , Plue Laurie , Williams Linda S. 
Published: November 2007

AbstractObjectivesPost‐stroke depression (PSD) is prevalent, often undiagnosed, and undertreated. The accuracy of detecting patients with post‐stroke depression in administrative databases has not been examined.The objective was to validate a case‐finding algorithm for post‐stroke depression (PSD) among veteran stroke survivors.MethodsWe conducted a retrospective cohort study of veterans admitted to two local VHA facilities for an inpatient episode of care for acute ischemic stroke. Our cohort included all patients from two medical centers who were identified in the fiscal year (FY) 2001 VHA inpatient database using high specificity stroke ICD‐9 codes. FY 2002 VHA and Medicare inpatient, outpatient, and pharmacy data were used to examine the patients' 12‐month PSD status by using ICD‐9 depression codes and antidepressant use. We assessed our accuracy about patients' PSD from the administrative databases through standardized chart reviews.ResultsOf our 185 subject cohort, 50 (27%) were identified as having PSD. The most sensitive case‐finding algorithm for PSD included having an ICD‐9 code diagnosis for depression or receiving a prescription for an approved‐dosage of antidepressant medication. However, the algorithm of receiving an ICD‐9 code for primary or secondary diagnoses of depression revealed the largest positive predictive value.ConclusionsA case‐finding algorithm using outpatient ICD‐9 codes or medication was the most sensitive in identifying cases of PSD. The use of ICD‐9 codes alone may be adequate for characterizing a cohort with PSD. Intention for use should be considered when choosing an algorithm to detect PSD. Copyright © 2007 John Wiley & Sons, Ltd.
Modulating in vitro bone cell and macrophage behavior by immobilized enzymatically tailored pectins
Authors: Bussy Cyrill , Verhoef René , Haeger Ash , Morra Marco , Duval Jean‐Luc , Vigneron Pascale , Bensoussan Anne , Velzenberger Elodie , Cascardo Giovanna , Cassinelli Clara , Schols Henk , Knox J. Paul , Nagel Marie‐Danielle 
Published: November 2007

AbstractPrevious work has reported the results of a multidisciplinary effort producing a proof‐of‐concept on the use of pectic polysaccharides in the surface modification of medical devices. This study was designed to learn more about the capability of engineered rhamnogalacturonan‐I (RG‐I) fractions of apple pectin to control bone cell and macrophage behavior. Thermanox® or polystyrene Petri dishes were surface modified with two different modified hairy regions (MHRs) obtained by different enzymatic liquefaction processes of apples differing in relative amounts and lengths of their neutral side chains: (long‐haired) MHR‐α and (short‐haired) MHR‐B. Bone explants from 14‐day‐old chick embryos were cultured for 14 days on both pectic substrata. MHR‐B promoted cell migration and differentiation, MHR‐α did not. On MHR‐α, J774.2 macrophages grew well, their percentage in G1 phase was decreased and in S phase increased, and they did not secrete either proinflammatory‐cytokines or nitrites. Contrasting results were gained from macrophages on MHR‐B, except for nitrite secretion. Thus, we conclude that coatings from tailored pectins show different biological activities in vitro and are potential innovative candidates for improving the biocompatibility of medical devices in various applications. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Short‐term TNF‐Alpha treatment induced A2Badenosine receptor desensitization in human astroglial cells
Authors: Trincavelli Maria Letizia , Tonazzini Ilaria , Montali Marina , Abbracchio Maria Pia , Martini Claudia 
Published: November 2007

AbstractLong‐term glial cell treatment with the proinflammatory cytokine TNF‐alpha has been demonstrated to increase the functional responsiveness of A2Badenosine receptors (A2BARs), which in turn synergize with the cytokine inducing chronic astrogliosis. In the present study, we investigated the short‐term effects of TNF‐alpha on A2BAR functional responses in human astroglial cells (ADF), thus simulating the acute phase of cerebral damage which is characterized by both cytokine and adenosine high level release. Short‐term TNF‐alpha cell treatment caused A2BAR phosphorylation inducing, in turn, impairment in A2BAR‐G protein coupling and cAMP production. These effects occurred in a time‐dependent manner with a maximum following 3‐h cell exposure. Moreover, we showed PKC intracellular kinase is mainly involved in the TNF‐alpha‐mediated regulation of A2BAR functional responses. The results may indicate the A2BAR functional impairment as a cell defense mechanism to counteract the A2Breceptor‐mediated effects during the acute phase of brain damage, underlying A2BAR as a target to modulate early inflammatory responses. J. Cell. Biochem. 104: 150–161, 2008. © 2007 Wiley‐Liss, Inc.
Mechanisms of inhibition of dehydroepiandrosterone upon corticosterone release from rat zona fasciculata‐reticularis cells
Authors: Chang Ling‐Ling , Wun Wan‐Song Alfred , Wang Paulus S. 
Published: November 2007

AbstractWe have demonstrated that dehydroepiandrosterone (DHEA) acts directly on rat zona fasciculata‐reticularis (ZFR) cells to diminish corticosterone secretion by an inhibition of post‐cAMP pathway, and decreases functions of steroidogenic enzymes after P450scc as well as steroidogenic acute regulatory (StAR) protein expression. However, the mechanisms by which DHEA engages with environmental messenger signals which translate into interfering StAR protein expression are still unclear. This study explored the effects of DHEA on the phosphorylation/activation of extracellular signal‐regulated kinases (ERKs). ERK activation resulted in enhancing phosphorylation of steroidogenic factor‐1 (SF‐1) and increased StAR protein expression. ZFR cells were incubated in the presence or absence of adrenocorticotropin (ACTH), forskolin (FSK), 25‐OH‐cholesterol, U0126, and H89 at 37°C. The concentration of corticosterone released into the media was measured by radioimmunoassay (RIA). The cells were used to extract protein for Western blot analysis of ERKs or StAR protein expression or immunoprecipitation of SF‐1 analysis. The results suggested that (1) ERK pathway of rat ZFR cells might be PKA dependent, (2) ERK activity was required for SF‐1 phosphorylation to upregulate steroidogenesis in rat ZFR cells, and (3) DHEA did not affect ERK phosphorylation, however, it attenuated forskolin‐stimulated SF‐1 phosphorylation to affect StAR protein expression. J. Cell. Biochem. 104: 359–368, 2008. © 2007 Wiley‐Liss, Inc.
Diagnostic accuracy of endometrial thickness to exclude polyps in women with postmenopausal bleeding
Authors: Timmermans Anne , Gerritse Maaike B.E. , Opmeer Brent C. , Jansen Frank W. , Mol Ben W. J. , Veersema Sebastiaan 
Published: November 2007

AbstractPurposeTo determine the accuracy of endometrial thickness measurement with transvaginal ultrasonography (TVUS) to diagnose endometrial polyps in women with postmenopausal bleeding in whom a carcinoma has been ruled out.MethodsIn women with postmenopausal bleeding, endometrial thickness was measured with TVUS. If endometrial thickness was >4 mm, office hysteroscopy was performed. At hysteroscopy, the uterine cavity was assessed for the presence of polyps. Patients with malignancy were excluded. We used receiver operating characteristics (ROC) analysis to assess the capacity of TVUS endometrial thickness measurement to diagnose endometrial polyps. Findings at hysteroscopy were considered to be the reference standard.ResultsWe included 178 patients with postmenopausal bleeding and endometrial thickness >4 mm. Hysteroscopy showed an endometrial polyp in 90 patients (50%). The ROC analysis revealed that endometrial thickness had an area under the curve of 0.64 in the diagnosis of endometrial polyps.ConclusionIn women with postmenopausal bleeding in whom carcinoma has been ruled out, measurement of endometrial thickness with TVUS is not useful in the diagnosis of endometrial polyps. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2008
An AFM study on mechanical properties of native and dimethyl suberimidate cross‐linked pericardium tissue
Authors: Matyka K. , Matyka M. , Mróz I. , Zalewska‐Rejdak J. , Ciszewski A. 
Published: November 2007

AbstractChanges in the stiffness of hog pericardium tissue, native and treated with dimethyl suberimidate (DMS), are investigated by atomic force microscopy (AFM). Young's modulus is calculated on the basis of the Hertz–Sneddon model. The cross‐linking process increases the stiffness of the tissue. The values of Young's modulus are higher for the DMS stabilized pericardium than for the native one. We also observe that the Young's modulus of native tissue increases when the time between getting the biological material and performing the measurements is longer. This process is probably connected with natural degradation of the biological samples. Copyright © 2007 John Wiley & Sons, Ltd.
Cyclical long‐range dependence and the warming effect in a long temperature time series
Authors: Gil‐Alana L. A. 
Published: November 2007

AbstractIn this paper, we propose a new approach for modelling a long temperature time series, using fractional cyclical integration. This model is based on the observation that the estimated spectrum of the series (the average annual temperature in Central England, 1659–2001) has its highest value at a frequency which is not zero, thus suggesting the existence of cycles at other frequencies. The results based on a fractional cyclical model show that there is a significant warming effect throughout the sample of about 0.22 °C/century. However, if we concentrate exclusively on the data corresponding to the 20th century that value increases to 0.64%. Moreover, the results in the paper show that a fractionally cyclically integrated model can be a competing alternative to other approaches based on fractional integration at the zero frequency. Copyright © 2007 Royal Meteorological Society
Effects of delayed stabilization on fracture healing
Authors: Miclau Theodore , Lu Chuanyong , Thompson Zachary , Choi Paul , Puttlitz Christian , Marcucio Ralph , Helms Jill A. 
Published: November 2007

AbstractPrevious studies have revealed that delayed internal fixation can stimulate fracture callus formation and decrease the rate of nonunion. However, the effect of delayed stabilization on stem cell differentiation is unknown. To address this, we created fractures in mouse tibiae and applied external fixation immediately, at 24, 48, 72, or 96 h after injury. Fracture healing was analyzed at 10 days by histological methods for callus, bone, and cartilage formation, and the mechanical properties of the calluses were assessed at 14 days postinjury by tension testing. The results demonstrate that delaying stabilization for 24–96 h does not significantly affect the volume of the callus tissue (TV) and the new bone (BV) that formed by 10 days, or the mechanical properties of the calluses at 14 days, compared to immediate stabilization. However, delaying stabilization for 24–96 h induces 10–40× more cartilage in the fracture calluses compared with fractures stabilized immediately. These findings suggest that delaying stabilization during the early phase of fracture healing may not significantly stimulate bone repair, but may alter the mode of bone repair by directing formation of more cartilage. Fractures that are not rigidly stabilized form a significantly larger amount of callus tissue and cartilage by 10 days postinjury than fractures stabilized at 24–96 h, indicating that mechanical instability influences chondrocytes beyond the first 96 h of fracture healing. © 2007 Orthopaedic Research Society. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1552–1558, 2007
Characterization of indigo carmine with surface‐enhanced resonance Raman spectroscopy (SERRS) using silver colloids and island films, and theoretical calculations
Authors: Peica N. , Kiefer W. 
Published: November 2007

AbstractThe application of resonance Raman (RR) and surface‐enhanced resonance Raman (SERR) spectroscopies to the qualitative and semiquantitative analysis of the artificial dye indigo carmine has been examined using sodium‐citrate‐reduced silver colloid and island films with various roughnesses. Additional, the Raman spectrum of the solid state and density functional theory (DFT) calculations helped to a better understanding of the fully optimized geometry and of the vibrational wavenumbers of the dye. A strong chemical interaction of indigo carmine with the silver colloidal particles was observed mainly at very low concentration of 0.03 × 10−9 M and with silver film surfaces at a concentration of 10−4 M. The indigo carmine orientation possibilities while going to different metallic substrates are discussed. Copyright © 2007 John Wiley & Sons, Ltd.
Vibrational relaxation study in carbonyl containing molecule: role of hydrodynamic and dispersion forces
Authors: Devi T. Gomti 
Published: November 2007

AbstractThe isotropic Raman component of the C = O stretching mode of ethyl acetate (EA) was analyzed using various polar and nonpolar solvents. It was found that the bandshape approaches towards Lorentzian at high dilution using the curve‐fitting method. The isotropic Raman band was also analyzed by estimating the correlation coefficient with reference to the Lorentzian lineshape using a simple method of linear‐curve fitting. The effects of dispersion and hydrodynamic forces on bandwidth were studied in details. The vibrational relaxation rate was studied using certain parameters and it was found that the microscopic based parameter can explain the complexities occurring in solute–solvent interactions. Copyright © 2007 John Wiley & Sons, Ltd.
Raman and IR spectra of the unstable ionic species potassium trimethylsilanolate: The role of the counterion in its theoretical interpretation
Authors: Montejo Manuel , Ureña Francisco Partal , Márquez Fernando , Ingraín Antonio Marchal , González Juan Jesús López 
Published: November 2007

AbstractWe have accomplished a reliable assignment of the vibrational spectra of the ionic species potassium trimethylsilanolate, which is unstable towards hydrolysis and self‐condensation, by means of the combined use of experimental data and theoretical density functional theory (DFT) calculations. We report the first record of the Raman spectrum of the pure solid. Additionally, we have newly recorded its IR spectrum in Nujol mull and for the first time in Fluorolube mull, completing the experimental data available in the literature about this chemical species. Further, in order to discuss the convenience of including the counterion in the model used for the quantum‐mechanical calculations of its vibrational spectra, we have compared the performance of three different theoretical models, namely, the isolated trimethylsilanolate anion, a theoretical monomer of potassium trimethylsilanolate and a simplified ionic cluster model based on its crystalline structure. Copyright © 2007 John Wiley & Sons, Ltd.
Hochleistungsbremsscheiben aus Faserverbundkeramik
Authors: Rosenlöcher J. , Deinzer G. , Waninger R. , Münchhoff J. 
Published: November 2007

AbstractDie Audi AG ist einer der weltweit führenden Automobilhersteller der Premiumklasse. Eines der Hauptziele der Technischen Entwicklung bei Audi ist der Einsatz neuartiger und innovativer Werkstoffe. Daher bietet die Audi AG nach intensiver Entwicklung und Erprobung für mehrere Fahrzeugmodelle Keramikbremsscheiben an. Diese Bremsscheiben bestehen aus einer kohlenstoffkurzfaserverstärkten Siliziumkarbidkeramik, einem sog. CMC‐Werkstoff. Dieser Werkstoff wird in einem aufwendigen Verfahren über die Schmelzinfiltration von Kohlenstoff‐Preformen mit Silizium hergestellt. Die Vorteile dieser innovativen und leistungsfähigen Bremsscheiben aus C/SiC‐Keramik sind das geringe Gewicht und dadurch die Reduzierung der ungefederten rotierenden Massen, der geringe Verschleiß über Betriebsdauer, die Temperatur‐ und Fadingstabilität und die Korrosionsbeständigkeit. Aufgrund der materialspezifischen Eigenschaften wurde das gesamte Bremssystem überarbeitet und die Systemperipherie angepasst.