bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular covered stent and video-assisted thoracoscopic surgery for Aortoesophageal fistula caused by esophageal fishbone: a case report
Authors: Chen Jianfeng 
Published: March 2024

Abstract
Background
Aortoesophageal fistula (AEF) is a rare condition characterized by communication between the aorta and esophagus. AEF caused by an esophageal foreign body is even rare, and there is currently no recommended standard treatment protocol. We report a case of delayed aortic rupture after the endoscopic removal of a fish bone, which was successfully treated with a combined approach of vascular stenting and thoracic surgery.

Case presentation
A 33-year-old man presented to the hospital after experiencing chest discomfort for 3 days following the accidental ingestion of a fish bone. Under endoscopic guidance, the fish bone was successfully removed, and the patient was subsequently admitted for medical therapy. On the fourth postoperative day, the patient suddenly developed hematemesis, and chest computed tomography angiography revealed the presence of an AEF. This necessitated urgent intervention; hence, thoracic surgery was performed and a vascular-covered stent was placed. Following the surgical procedure, the patient received active medical treatment, recovered well, and was successfully discharged from the hospital.

Conclusions
In patients with esophageal perforation caused by foreign bodies, hospitalization for observation, computed tomography angiography examination, early use of antibiotics, and careful assessment of aortic damage are advised. Thoracic endovascular aortic repair and esophageal rupture repair may have benefits for the treatment of AEF.
TRF2 as novel marker of tumor response to taxane-based therapy: from mechanistic insight to clinical implication
Authors: Iachettini Sara , Terrenato Irene , Porru Manuela , Di Vito Serena , Rizzo Angela , D’Angelo Carmen , Petti Eleonora , Dinami Roberto , Maresca Carmen , Di Benedetto Anna , Palange Aldo , Mulè Antonino , Santoro Angela , Palazzo Antonella , Fuso Paola , Stoppacciaro Antonella , Vici Patrizia , Filomeno Lorena , Di Lisa Francesca Sofia , Arcuri Teresa , Krasniqi Eriseld , Fabi Alessandra , Biroccio Annamaria , Zizza Pasquale 
Published: March 2024

Abstract
Background
Breast Cancer (BC) can be classified, due to its heterogeneity, into multiple subtypes that differ for prognosis and clinical management. Notably, triple negative breast cancer (TNBC) – the most aggressive BC form – is refractory to endocrine and most of the target therapies. In this view, taxane-based therapy still represents the elective strategy for the treatment of this tumor. However, due variability in patients’ response, management of TNBC still represents an unmet medical need.
Telomeric Binding Factor 2 (TRF2), a key regulator of telomere integrity that is over-expressed in several tumors, including TNBC, has been recently found to plays a role in regulating autophagy, a degradative process that is involved in drug detoxification.
Based on these considerations, we pointed, here, at investigating if TRF2, regulating autophagy, can affect tumor sensitivity to therapy.

Methods
Human TNBC cell lines, over-expressing or not TRF2, were subjected to treatment with different taxanes and drug efficacy was tested in terms of autophagic response and cell proliferation. Autophagy was evaluated first biochemically, by measuring the levels of LC3, and then by immunofluorescence analysis of LC3-puncta positive cells. Concerning the proliferation, cells were subjected to colony formation assays associated with western blot and FACS analyses. The obtained results were then confirmed also in mouse models. Finally, the clinical relevance of our findings was established by retrospective analysis on a cohort of TNBC patients subjected to taxane-based neoadjuvant chemotherapy.

Results
This study demonstrated that TRF2, inhibiting autophagy, is able to increase the sensitivity of TNBC cells to taxanes. The data, first obtained in in vitro models, were then recapitulated in preclinical mouse models and in a cohort of TNBC patients, definitively demonstrating that TRF2 over-expression enhances the efficacy of taxane-based neoadjuvant therapy in reducing tumor growth and its recurrence upon surgical intervention.

Conclusions
Based on our finding it is possible to conclude that TRF2, already known for its role in promoting tumor formation and progression, might represents an Achilles’ heel for cancer. In this view, TRF2 might be exploited as a putative biomarker to predict the response of TNBC patients to taxane-based neoadjuvant chemotherapy.
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Authors: Cheng Chen , Yang Hao , Yang Chan , Xie Juan , Wang Jinshen , Cheng Luping , He Jianfu , Li Honglian , Yuan Haoxing , Guo Fangfang , Li Minmin , Liu Shuwen 
Published: March 2024

Abstract
Background
Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to irreversible renal damage in LN patients and further progresses to chronic kidney disease (CKD) and the end stage of renal disease (ESRD), developing new targets to prevent LN fibrotic progression could lead to a feasible treatment strategy for LN patients.

Methods
In this study, we examined YAP activation and LATS2 downregulation in LN kidney biopsy samples (LN: n = 8, normal: n = 2) and lupus-prone MRL/lpr mice (n = 8 for each disease stage). The function of LATS2 was further investigated by in situ injection of Ad-LATS2 into mice with LN (n = 6 mice per group). We examined the role of SIAH2-LATS2 regulation by IP-MS and co-IP, and the protective effect of the SIAH2 inhibitor was investigated in mice with LN.

Results
Restoring LATS2 by an adenovirus in vivo alleviated renal fibrotic damage in mice with LN. Moreover, we found that LATS2 was degraded by a K48 ubiquitination-proteasome pathway mediated by SIAH2 and promoted YAP activation to worsen fibrosis progression in LN. The H150 region of the substrate binding domain (SBD) is an important site for SIAH2-LATS2 binding. The SIAH2-specific inhibitor vitamin K3 protected against LN-associated fibrotic damage in vivo.

Conclusion
In summary, we identified the SIAH2-LATS2 axis as an attractive intervention target in LN to alter the resistance to fibrosis.
Effect of remission, clinical remission with active serology, and glucocorticoid dosage on the pregnancy outcome of pregnant patients with systemic lupus erythematosus
Authors: Nakai Takehiro , Honda Nanase , Soga Eri , Fukui Sho , Kitada Ayako , Yokogawa Naoto , Okada Masato 
Published: March 2024

Abstract
Background
Remission is a key treatment target in systemic lupus erythematosus (SLE) management. Given the direct correlation between lupus flares and elevated risks of adverse pregnancy outcomes (APOs), securing remission before conception becomes crucial. However, the association between clinical remission with active serology, and the risk of APOs is not thoroughly understood. Additionally, determining the optimal glucocorticoid dosage during pregnancy to mitigate APO risks remains under-researched. This study investigated the risk of APOs in relation to remission/serological activity status in patients in clinical remission/glucocorticoid dosage.

Methods
Pregnant patients with SLE, who were followed up at two Japanese tertiary referral centers, and had their remission status assessed at conception, were included in this study. We categorized the patients into two groups based on whether they achieved Zen/Doria remission at conception and analyzed the APO ratio. We also examined the influence of serological activity in pregnant patients with clinical remission and analyzed the optimal glucocorticoid dosage to minimize the APO ratio.

Results
Of the 96 pregnancies included, 59 achieved remission at conception. Pregnant patients who achieved remission showed a significant decrease in the APO ratio compared with those who did not. (overall APO: odds ratio (OR) 0.27, 95% confidence interval (CI) 0.11–0.65, p < 0.01, maternal APO: OR 0.34, 95%CI 0.13–0.85, p = 0.021, neonatal APO: OR 0.39, 95%CI 0.17–0.90, p = 0.028). Conversely, no statistical difference was observed in the APO ratio based on serological activity in pregnant patients with clinical remission. (overall APO: OR 0.62, 95%CI 0.21–1.79, p = 0.37, maternal APO: OR 1.25, 95%CI 0.32–4.85, p = 0.75, neonatal APO: OR 0.83, 95%CI 0.29–2.39, p = 0.73). A glucocorticoid dose of prednisolone equivalent ≥ 7.5 mg/day at conception correlated with increased APO. (overall APO: OR 3.01, 95%CI 1.23–7.39, p = 0.016, neonatal APO: OR 2.98, 95% CI:1.23–7.22, p = 0.016).

Conclusions
Even with active serology, achieving clinical remission can be a clinical target for reducing APOs in patients who wish to conceive. In addition, if clinically feasible, reducing the glucocorticoid dosage to < 7.5 mg/day before conception could be another predictive factor.
Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications
Authors: Qin Yuanyuan , Yang Ping , He Wanhong , Li Dongze , Zeng Lisha , Li Junle , Zhou Tingting , Peng Juan , Cao Ling , Huang Wei 
Published: March 2024

AbstractAlzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it. With the development of mass spectrometry and proteomics, an increasing number of novel HPTMs, including lactoylation, crotonylation,β-hydroxybutyrylation, 2-hydroxyisobutyrylation, succinylation, and malonylation, have been identified. These novel HPTMs closely link substance metabolism to gene regulation, and an increasing number of relevant studies on the relationship between novel HPTMs and AD have become available. This review summarizes the current advances and implications of novel HPTMs in AD, providing insight into the deeper pathogenesis of AD and the development of novel drugs.
Profound postinduction hypotension precipitated by immune checkpoint inhibitors: a case report
Authors: Che Lu , Zhu Afang , Chen Wen , Yu Chunhua 
Published: March 2024

Abstract
Background
With the increasing use of immune checkpoint inhibitors (ICIs) in cancer therapy, perioperative healthcare professionals need to be vigilant about potential immune-related adverse events (irAEs). We report a case of severe postinduction hypotension in a patient undergoing laparotomy due to suspected intraabdominal bleeding from gastric cancer and Krukenberg tumors, caused by unrecognized hypothyroidism precipitated by ICIs.

Case presentation
A 65-year-old Chinese female with a history of gastric adenocarcinoma and Krukenberg tumors, previously treated with nivolumab, presented to the emergency room with abdominal pain and hypotension. Despite ruling out other causes, including hypovolemia and anaphylaxis, her hypotension persisted. The patient was found to have severe hypothyroidism, likely an irAE from the use of nivolumab. Thyroxine replacement therapy resolved the hypotension, and the patient recovered uneventfully after surgery.

Conclusions
This case underscores the importance of considering irAEs, such as hypothyroidism, in patients treated with ICIs. Perioperative healthcare providers must remain vigilant for potential complications and promptly recognize and manage irAEs to optimize patient outcomes.
Treatment options and outcomes for delayed scapular anatomical neck fractures: a case report and review of the literature
Authors: Amouzadeh Omrani Farzad , Khak Mohammad , Tavakoli Darestani Reza , Afzal Sina , Baroutkoub Mojtaba , Aghaalikhani Mahdi , Barati Hasan 
Published: March 2024

Abstract
Introduction
Scapular anatomical neck fractures are among the most infrequent shoulder girdle fractures. Only seven radiologically confirmed cases of scapular anatomical neck fractures have been documented in the literature to date, of which only one case underwent delayed surgery.

Case presentation
A 34-year-old male Persian patient with morbid obesity was diagnosed with a scapula anatomical neck fracture after a motor vehicle collision. The radiographic assessment of the patient indicated an increase in the scapular glenopolar angle (73.9°). Due to concurrent chest and head injuries, surgical intervention was deferred until 6 weeks following the injury. The posterolateral limited Dupont–Evrard approach was used because of the patient’s extremely high body mass index. Two plates were utilized to achieve stable fixation of the glenoid neck fracture. Following a 1 year follow-up period, complete fracture union was successfully attained, resulting in a constant score of 79.

Conclusions
The most accurate radiographic indicators of these fractures are a superior fracture line located laterally to the coracoid process, a small inferior spike, and an elevated glenopolar angle. The only tendon attached to the glenoid is the long head of the triceps, making these fractures unstable; therefore, surgery is required in the majority of instances. The small size of the fractured component makes stabilization more difficult. Overall, anatomical scapular neck fractures are extremely uncommon and distinguished from other scapular fractures by their unique radiological and biomechanical characteristics. This case highlights the challenges encountered when managing scapular fractures in patients with morbid obesity. The delayed surgical intervention and the choice of surgical approach tailored to the patient’s specific anatomical and physiological considerations proved to be effective in achieving a favorable outcome.
Effects of short-term preoperative intranasal dexmedetomidine plus conventional treatment on delirium following cardiac surgery in patients with sleep disorders
Authors: Fang Jun , Yang Jia , Zhai Mingyu , Zhang Qiong , Zhang Min , Xie Yanhu 
Published: March 2024

Abstract
Study objectives
To assess whether preoperative dexmedetomidine (DEX) nasal drips combined with conventional treatment could mitigate the occurrence of postoperative delirium (POD).

Design
A prospective randomised controlled study.

Setting
The cardiac surgery intensive care unit (CSICU) and patient hospitalisation ward at a university hospital.

Participants
A total of 100 patients (aged ≥60 years) undergoing cardiac surgery at a university hospital between 7 January 2022, and 30 November 2022 met the eligibility criteria and were included in the study.

Interventions
Patients with sleep disorders (Pittsburgh Sleep Quality Index ≥8) were divided into two groups: Group A (the placebo group, n=50), receiving a short-term preoperative placebo combined with conventional treatment and Group B (the DEX group, n=50), receiving short-term preoperative DEX combined with conventional treatment.

Measurements and results
The Confusion Assessment Method for the ICU (CAM-ICU) was used for POD assessment in the CSICU, while the CAM was employed to assess delirium in the patient ward. Group B demonstrated a reduced incidence of POD compared to Group A (12% vs. 30%, odds ratio: 0.318, 95% confidence interval: 0.112–0.905, p=0.027).

Conclusion
The combined treatment involving DEX demonstrated a decreased incidence of POD in elderly individuals with sleep disorders undergoing cardiac surgery compared to the placebo combination treatment.

Trial registration
URL: www.chictr.org.cn with registration number ChiCTR 2100043968, registered on 06/03/2021.
Optimal control of susceptible mature pest concerning disease-induced pest-natural enemy system with cost-effectiveness
Authors: Mathur Kunwer Singh , Kumar Bhagwan 
Published: March 2024

Abstract
This article addresses the pressing issue of pest outbreaks in India, which poses significant challenges for farmers and ecologists. A novel system is proposed for effective control that leverages natural enemies. Here, the pests are classified into juveniles and mature individuals, further categorized as susceptible or infected. The study introduces harvesting, incorporating external efforts and natural phenomena, in a pest-epidemic prey–predator system featuring a prey-stage structure. The model reveals three equilibria: trivial, boundary (indicating the absence of natural enemies), and interior equilibria. Notably, the trivial equilibrium is consistently unstable. As demonstrated by stability analysis, the survival or extinction of natural enemies hinges on control variables, including the harvesting rate, disease transmission rate, and natural death rate. Local stability is assessed using the Routh–Hurwitz criterion, while global stability is explored through the Lyapunov method. Furthermore, optimal control theory and Pontryagin’s maximum principle are applied for model optimization, unveiling crucial optimality conditions and determining the optimal harvesting rate for susceptible mature prey. Numerical computations validate theoretical insights, offering valuable guidance for formulating policies that optimize the control of susceptible adult pests within a disease-induced pest-natural enemy system, ensuring sustained cost-effectiveness.
A mathematical study of the adrenocorticotropic hormone as a regulator of human gene expression in adrenal glands
Authors: Manickam A. , Jaison A. Benevatho , Lakshmi D. , Singh Ram , Pravina C. T. Dora 
Published: March 2024

Abstract
In this research, we have introduced compartments for asymptomatic and symptomatic individuals, along with reduced susceptibility, as key factors defining our investigation. The study is carried out in diverse scenarios, considering them as crucial for the essential generation number of the model, set at 3.18(

r

0

>
1

{r}_{0}\gt 1

). The persistent reproduction differential method was used to explore the impact of continuous adrenocorticotropic hormone (ACTH) administration on the global gene expression in primary cultures of both fetal and adult adrenal cells. The study also investigates ACTH’s genetic effects on both adult and fetal human adrenal cells. The conclusion of this study is demonstrated through relevant and correct medical applications.
Sacrificial anode materials to protect marine grade steel structures: a review
Authors: Vaira Vignesh Ramalingam , Sathiya P. 
Published: March 2024

Abstract
Marine structures are constantly exposed to the corrosive effects of seawater, making effective corrosion protection crucial for their longevity and performance. Sacrificial anodes, commonly made of zinc, aluminum, or magnesium alloys, are widely employed to mitigate corrosion by sacrificing themselves to protect the steel structures. However, the selection and implementation of sacrificial anode materials present various challenges that need to be addressed. This paper explores the challenges associated with sacrificial anode materials for steel structures and provides potential solutions. To overcome these challenges, the paper proposes solutions such as using advanced alloy compositions, protective coatings, hybrid anode systems, and improved design considerations. Furthermore, the importance of monitoring techniques to assess the performance and remaining lifespan of sacrificial anodes is emphasized. Several case studies and experimental findings are discussed to illustrate the effectiveness and limitations of sacrificial anode materials based on zinc alloys, aluminum alloys, and magnesium alloys. The paper highlights the need for ongoing research and development efforts to address the evolving demands of corrosion protection in marine environments.
Using micro spheres as reference artifacts for the in-situ characterization of tactile 3D micro probes along the probing sphere’s equator
Authors: Oertel Erik , Manske Eberhard 
Published: March 2024

Abstract
Nano and micro coordinate measuring machines (CMMs) have been developed for the characterization of small dimensional features. They require a procedure which enables a traceable and precise characterization of probing spheres. In this contribution we explore the use of well characterized micro spheres as reference artifacts for the in-situ characterization of probing spheres along the probing sphere’s equator. The spheres are characterized using a strategy which is based on a set of tactile surface scans in conjunction with a stitching-algorithm. These micro spheres serve as a reference for the in-situ characterization of a tactile 3D micro probe on a nano measuring machine (NMM-1). Our investigations are based on a sample of eight spheres sourced from two different suppliers. Although the sample is small, we could already observe characteristics which seem to be typical for spheres of a certain type (i.e. nominal radius and material). The experiments indicate that micro spheres are a suitable reference artifact for tactile 3D micro probes. We were able to reproduce the measured mean radius of the probing sphere with a standard deviation of 31 nm using reference spheres whose nominal radius covers a range of 89 µm (61 µm up to 150 µm).
Afterword: Running with the Metaphor of Social Invisibility
Authors: Peeren Esther 
Published: March 2024

Abstract
In this afterword, I reflect on the contributions gathered in this special issue, which make clear that social invisibility is multivalent, as visibility, invisibility, and the oscillation between them have different meanings and effects in different social and literary contexts. To the points made about social invisibility in the contributions, I add three more. First, after considering social disappearance as a possible alternative to social invisibility, I conclude that the lack of clear boundaries between these two highly elastic metaphors should not be seen as a problem, but as fruitful: running with both metaphors allows us to arrive at a better understanding of the lives led by particular precaritized groups, and to compare these lives across historical and cultural contexts, as well as across approaches and methods. Second, while social invisibility and social disappearance have predominantly been used to figure disempowerment, it should be acknowledged that escaping notice can also empower. A brief reading of Don DeLillo’s Cosmopolis illustrates the power self-chosen invisibility may impart to the privileged. Third, I argue that humanities approaches to fictionality and narrative and visual form, as found across different types of art and media, provide ways of thinking through social invisibility that add something valuable to empirical and ethnographic approaches in the social sciences. The main reason for this is that narrative and visual form can defamiliarize our perception of the social world, enabling us to notice again or notice differently what has become unremarkable.
Adubação nitrogenada e estirpes de rizóbios eficientes no desenvolvimento e produtividade do feijão-caupi
Authors: De jesus Cristina meira , Ferreira Joilson Silva , Paiva Talitta Silva dos santos , Souza Frankly Gomes , Melo Derlei Dias , Santos Rayka Kristian Alves 
Published: March 2024

Objetivou-se avaliar o efeito da inoculação com rizóbios associado à adubação nitrogenada sobre o crescimento e produtividade de cultivares de feijão-caupi. O experimento foi conduzido no campus experimental, onde foram testados dois isolados nativos e a estirpe BR3262 (recomendada para cultura) acrescidos de adubação nitrogenada (30,60 e 90 kg ha-1de N) e um controle sem adubação e inoculação e duas cultivares de feijão-caupi (BRS Guariba e Novaera). O delineamento experimental empregado foi em blocos casualizados, com quatro repetições, em esquema fatorial triplo (4 x 4 x 2). No florescimento, foram avaliados os seguintes parâmetros: Altura de plantas, diâmetro do colmo, massa seca de parte aérea, Índice SPAD e número de nódulos. Na colheita foram coletados dados dos componentes de produção: Número de vagens por planta, comprimento de vagem, número de sementes por vagem, massa de 100 grãos e produtividade. A inoculação com as estirpes de rizóbios favorecem a redução da adubação nitrogenada, resultando em incrementos no crescimento e produção da planta. O isolado nativo UESB R5 promoveu o maior lucro final e redução de gastos com adubação nitrogenada, nas duas cultivares.