bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring The Relationship Between Dietary Patterns and Obesity Among Nigerian Adults: A Cross-Sectional Study
Authors: Segun Asaolu , Zhang Bo , Mary Abiona Modupe , Kibenja Dennis , Ma Jie , Said Self , Adeniyi Idowu , Barrow Lamin F 
Published: March 2024

Abstract
Background/Objective: No previous study has investigated the association between dietary pattern and both general and abdominal obesity risk among adult in Nigeria. This study aimed to evaluate the associations between dietary patterns and the risk of obesity in the city of Iyin Ekiti, Southwestern Nigeria.
Methods and Study Designs: A total of 1003 adults were included in this cross-sectional study (males = 558; females = 445). BMI and WHR were used to access general and abdominal obesity respectively and they were categorized using WHO recommendation. Partial correlation analyses were performed to assess the associations between dietary patterns an BMI and WHR. Prevalence ratio between dietary pattern and both general and abdominal obesity were calculated using Robust Poisson Regression.
Results: The prevalence of general obesity among adults was 15.9%, (11.6% among men and 20.2% among women); abdominal obesity was 28.9% among males and 44.5% among females. Four dietary pattern was identified; diversified traditional pattern; typical traditional pattern; milk and bread pattern and egg and fish pattern. Diversified traditional pattern was negatively associated with BMI (PR = 0.571, 95%CI: 0.360~0.905, p = 0.017), and typical traditional pattern was positively associated with BMI (PR = 1.561, 95% CI: 1.043~2.339, p = 0.031) and WHR in females (PR = 1.849, 95% CI: 1.256~2.721, p = 0.005). In comparison to those in the lowest quartile, adults with the highest quartile of the typical traditional pattern had a higher risk for abdominal obesity (PR = 1.849, 95%CI = 1.256 ~ 2.721, p = 0.020).
Conclusion: This study reports an alarming increase in Obesity prevalence among Nigeria adults which is greatly influence by their lifestyle and eating pattern. We found out that a typical traditional food pattern was associated with a higher risk of both general and abdominal obesity, but a diverse traditional food pattern was associated to a reduced risk of general obesity.
Research on the dynamic development of Bed-Separations and ground subsidence based on large-deflection inclined thin-plate model
Authors: Li Yaxing , Yang Keming , WEI Xiang-ping , JIANG Ke-gui , TANG Wei 
Published: March 2024

Abstract
Coal mining under the Quaternary thick loose layer makes unique patterns of rock destruction. These patterns directly affect direct and main roof breakage, key strata flexural breakage, Bed-Separations development, ground subsidence, and other studies. In this paper, we developed an approach to solving the deflection of thin plates with additional lateral load and mid-plane force. The dynamic mechanical model of key strata deflection caused by dip coal seams with a thick loose layer is also established. The methods presented are based on the principle of large-deflection of thin-plate, energy method, and fracture mechanics theory. The 7225 work face in Anhui Province, China, was studied. The key strata deflection parameters in the study area were obtained, including 1) the initial and periodic incoming pressure steps of the roof, 2) the height of the caved zone, fractured zone, and continuous bending zone, and 3) the development of height and volume of Bed-Separations. The ground subsidence pattern was revealed as well. The dynamic development of the principal key strata (PKS) calculated by the proposed model is verified with the 3DEC numerical simulation. Meanwhile, 16 Sentinel 1-A images covering the mining period were collected, and the Small Baseline Subset (SBAS) technique was applied to monitor the mining subsidence. It is also cross-validated with the model-calculated subsidence and field measurements. The results showed that the proposed model could contribute to the quantitative analysis of key strata deflection breakage, Bed-Separations development, and ground subsidence caused by excavating inclined coal seams when a thick loose layer covers.
Association Between Depression and Subjective Well-being in older patients with Chronic Diseases in Rural Ethnic Areas of Qiannan, Guizhou: The Mediating Role of Social Support
Authors: Li Zhonglian , Qin Suxian , Zhu Yafen , Zhou Quanxiang , Yi Aijing , Mo Caiyun , Gao Jun , Chen Juhai , Wang Tianhui , Feng Zhanhui , Mo Xiangang 
Published: March 2024

Abstract
Objective: To explore the associations among social support, depression, and subjective well-being in older patients with chronic diseases in the rural ethnic regions of Qiannan, Guizhou.
Methods: This cross-sectional study enrolled oder patients with chronic diseases in Qiannan, Guizhou between June and September 2022. The social support, depression, and subjective well-being were assessed by a self-developed questionnaire on general information, the social support rating scale (SSRS), the geriatric depression scale (GDS-15), and the Memorial University of Newfoundland Happiness Scale (MUNSH), respectively.
Results: A total of 2,156 participants (1,104 males; average age of 71.15±8.04) were included. Their mean SSRS and MUNSH scores were 34.96±7.98 and 27.17±9.48, respectively. The GDS-15 score was 7.23±2.59, with 1529 individuals (70.9%) having depressive symptoms. Multivariate linear regression analysis revealed that mild depression (B = -7.795, 95% CI: -8.437 to -7.153, P < 0.001), moderate to severe depression (B = -11.631, 95% CI: -12.623 to -10.639, P < 0.001), and moderate social support (B = -2.661, 95% CI: -4.063 to -1.259, P < 0.001) were independently associated with subjective well-being. The structural equation model results revealed that the total effect of depression symptoms on subjective well-being in elderly patients with chronic diseases is -0.528, with a direct effect of -0.474 (95% CI: -0.503 to -0.443), accounting for 89.77% of the total effect. The mediating effect of social support on the association between depression and subjective well-being is -0.133 (95% CI: -0.070 to -0.041), constituting 10.23% of the total effect.
Conclusions: Older patients with chronic diseases in the rural ethnic areas of Qiannan, Guizhou, exhibited a high prevalence of depressive symptoms and low levels of subjective well-being. Social support partially mediated the association between depression and subjective well-being in this population. Thus, proactive measures are warranted to fortify the social support system for older patients with chronic diseases in Qiannan, Guizhou.
Molecular Evidence of high prevalence of Wolbachia Species in Wild-Caught Aedes albopictus and Aedes aegypti mosquitoes on Bioko Island, Equatorial Guinea
Authors: Giger Johanna N. , Hosch Salome , von Planta Nele G. , Bela Nestor Rivas , Fuseini Godwin , Oyana Raul Nguema Ncogo , Houag Mathias Leonard , Efiri Prudencio Bibang Engono , Maye Valeriano Oluy Nsue , García Guillermo A. , Phiri Wonder P. , Schindler Tobias , Daubenberger Claudia 
Published: March 2024

Abstract
Background: Distribution of Aedes albopictus and Aedes aegypti are currently unknown on Bioko Island Equatorial Guinea.
Methods: Aedes spp. were collected between February 2020 and August 2021 on Bioko Island as a by-product of malaria vector entomological surveillance. The mosquitoes were transferred to Switzerland. Utilizing qPCR (quantitative polymerase chain reaction) on extracted nucleic acids, the mosquitoes were distinguished between A. albopictus and A. aegypti. Subsequently, the host species of their last blood meal was identified. Metagenomic analyses of potential pathogens were performed using Oxford Nanopore sequencing. A qPCR assay to detect Wolbachia was developed and used to screen Aedes spp.
Results: A. albopictusrepresents the dominant Aedes species on Bioko Island. Aedes spp. mosquitoes predominately fed on humans, few A. albopictus positive pools additionally contained blood meals from dog or chicken. Eight out of nine tested Aedesspp. pools contained DNA sequences that matched to Wolbachia spp. assessed by metagenomics. The remaining 72 pools were tested by qPCR for presence of Wolbachiaspp. DNA. In total, 87% of all samples tested were positive for Wolbachia spp. A. albopictus seemed to be significantly more affected by Wolbachiaspp. than A. aegypti.
Conclusions: A. albopictus has become the dominant Aedes species on Bioko Island and can be found in all four districts. Wolbachiaspp. endosymbionts seem to be more prevalent in A. albopictus compared to A. aegypti. The impact of Wolbachiaspp. presence on potential transmission of Flaviviruses in these different local mosquito populations warrants further investigation.
Effect of rural-to-urban migration on the healthcare utilisation of middle-aged and elderly adults: evidence from the China Health and Retirement Longitudinal Study
Authors: Xu Lu , Bi Shengxian , Yang Songhao , Guo Dandan , Tan Huawei , li Lei , Yang Qijiao , Peng Xinyi , Zhang Xueyu , Chen Yingchun 
Published: March 2024

Abstract
Background: An increasing number of middle-aged and elderly adults are migrating from rural to urban areas for employment, to care for their younger generation and due to old age. As these age groups move into urban areas, their healthcare service utilisation are directly related to their health status and basic rights to survival. It also places higher demands on China’s healthcare service provision. This study aims to investigate the effect of middle-aged and elderly adults migrating from rural to urban areas on their healthcare service utilisation.
Methods: Panel data from Wave 3 (2015), Wave 4 (2018) and Wave 5 (2020) of the nationally representative China Health and Retirement Longitudinal Study were selected to obtain a sample of 456 participants in the treatment group and 9171 participants in the control group. The difference-in-differences propensity score matching estimator method was used to explore the effect of migrating to a city on the utilisation of healthcare services amongst middle-aged and elderly adults.
Results: Calliper nearest-neighbour matching significantly improved overall balance after matching. The DID regression results showed that middle-aged and elderly adults significantly reduced their number of hospitalisations when they moved to a city, with a DID value of −0.093 (p<0.05). However, no significant effect was observed on the number of outpatient visits (p>0.05). The DID results were consistent with the robustness test. Further examination of heterogeneity determined that it had a more significant negative effect on the number of hospitalisationsamongst individuals aged 45–59 years, of rural hukou status and with poor self-assessed health status.
Conclusion: Middle-aged and elderly migrants moving to cities may reduce their healthcare utilisation. The government should improve its outpatient reimbursement policy and the policy of medical treatment in other places; encourage the society, community and family to give more attention to middle-aged and elderly adults migrating to cities; improve their health literacy and help them set up the correct concept of medical service utilisation to promote the health equity of migrant populations.
Advancing Key Expansion Techniques: Integrating Cross-Coupled Map Lattice and Dynamic S- Box for Superior Cryptographic Security
Authors: Li Yuxuan 
Published: March 2024

Abstract
This research investigates the security loopholes inherent in the traditional Advanced Encryption Standard (AES) key expansion mechanism, notably its sequential and reversible configuration that permits the derivation of subsequent round keys from any obtained round key. To counteract these vulnerabilities, we introduce a novel key expansion strategy that leverages dynamic Substitution-boxes (S-boxes) alongside the innovative application of cross-coupled lattice mapping. Our approach includes the development of a new one-dimensional chaotic map integrated into the cross-coupled map lattice to enhance its chaotic dynamics. Utilizing this enhanced lattice, we devise a dynamic S-box generation method. This method, rooted in the cross-coupled lattice mapping of a spatiotemporal chaotic system, yields an S-box with unique security features. Rigorous testing and validation demonstrate the S-box's superior defense against a broad spectrum of cryptographic threats. Furthermore, by embedding cross-coupled lattice mapping into the key expansion routine, we elevate the algorithm's complexity and render it non-reversible. This iterative implementation of the lattice mapping negates the possibility of deducing any round key or the original key from a single round key. Exhaustive experimental analyses validate the proposed key expansion algorithm's independence and adaptability, underscoring its improved security capabilities. The algorithm exhibits robust resistance to conventional side-channel and differential attacks, performing exceptionally in real-world application scenarios. Our study delivers a groundbreaking key expansion methodology that significantly enhances cryptographic security, offering a substantial contribution to the encryption domain and strengthening the overall security infrastructure of encryption algorithms.
Synthesis and Improving the Crystallinity of a Squaranine Covalent Organic Framework by Investigating the Co-Catalyst Effect and Using It as a green and Metal-Free Catalyst for the synthesis of enaminones
Authors: Ramezani M. Sadegh , Safaei Sadegh , Goodarzi Zahra , Moradi Mahsa 
Published: March 2024

Abstract
Herein, a modified synthesis method was presented and the effect of using an aqueous acetic acid solution in the process of synthesizing SQCOF was investigated. The addition of a catalytic amount of aqueous acetic acid solution as a co-catalyst has contributed to improved crystallinity quality. Effective parameters of the acid catalyst and the solvent were optimized and the synthesized SQCOF was used as a metal-free catalyst with Bronsted acid groups in the condensation reaction between 1,3-dicarbonyl groups and primary amines. This COF performs excellently as an acidic catalyst with a highly crystalline structure. SQCOF was applied in solvent-free conditions to synthesize enaminones at ambient temperature by gentle manual grinding with a pestle and mortar. High performance and efficiency (62 to 96 %), high TOF (833 to 1283 h-1), short reaction time, easy workup, elimination of toxic organic solvents, removal of metaled catalysts, and green conditions are the main advantages of this study. SQCOF shows good chemical stability and recyclability (7 runs) and acted as a successful catalyst in the synthesis of enaminones.
Upcycling of tetra pack waste cellulose into reducing sugars for bioethanol production using Saccharomyces cerevisiae
Authors: Rinki . , Yadav Pooja , Sharma Aditya , Dahiya Pushpak , Kumar Aakash , Walia Abhishek , Bhatt Arvind Kumar , Bhatia Ravi Kant 
Published: March 2024

Abstract

Bioethanol production from waste materials offers a promising avenue for sustainable energy and waste management. In this study, fermentable sugars derived from tetra pack waste cellulose were biotransformed into bioethanol using Saccharomyces cerevisiae. Tetra pack waste (180 g) yielded tetra pack cellulosic pulp (TPCP) of 145 g, after removing the different layers representing 80.56±0.32% of the original weight. Cellulase from Bacillus sp. RL-07, with a cellulolytic potential of 6.98±0.36 U/ml, released 32.72±0.12 mg/ml of reducing sugars, achieving 44.60±0.56% saccharification of TPCP under optimized conditions. Subsequent fermentation of the broth (1 L) with tetra pack cellulosic pulp hydrolysate (TPCPH) (50% v/v), containing 5.12 g of reducing sugars, by S. cerevisiaeyielded 1.42 g of bioethanol per g of reducing sugars under optimized conditions, with a volume productivity of 0.24 g/l/h and a purity of 96.42% was confirmed by GC/MS analysis. The findings of this research demonstrated the potential of tetra pack waste for bioethanol production, contributing to sustainable waste management, addressing energy shortages, and mitigating environmental pollution, thereby supporting goals of sustainable growth and development.
The Study on Deformation and Mechanical Properties of Surrounding Rock to Primary Arch Cover Met
Authors: Hao Ziyi 
Published: March 2024

Abstract

In order to explore the stress and deformation mechanism of surrounding rock in the construction process of the primary arch cover method, the finite difference method is used to simulate the construction process of the primary arch cover method of shallow buried large section hard rock tunnel. Combined with the monitoring data of the project site, the stress and deformation law of the tunnel surrounding rock under the influence of time and space effect are analyzed. In addition, the excavation process of the double-layer superimposed primary arch cover method and the traditional arch cover method is compared. Based on the stress and deformation characteristics of the tunnel surrounding rock, the technical advancement of the double-layer primary arch cover method is quantified. The results show that after the tunnel excavation is completed, the vertical displacement of the tunnel surrounding rock is mainly concentrated in the vault and arch bottom of the tunnel. The maximum uplift displacement is 7.263 mm and the maximum subsidence displacement is 14.09 mm. The settlement of the tunnel vault is roughly divided into three stages: slow settlement, rapid settlement and settlement stability; it can be seen from the comprehensive longitudinal span and section monitoring data that the double-layer superimposed primary arch cover method can better reduce the deformation of surrounding rock and increase the stability of the tunnel during excavation.
Safety Evaluation for Nickel Release of Nickel–Titanium alloys Cardiovascular stents
Authors: Liu Bin , Hu Yafan , Xu Kai , Zhang Bo , Liu Dong , Wu Changyan , Han Xiuyun , Han Peng , Lu Jian , Han Naishui 
Published: March 2024

Abstract

Nickel (Ni) is a major element of several alloys for implantable cardiovascular devices (stents and blockers).Due to the lack of reliable research models, there is no domestic and international evaluation system for Ni release in the medical device field before 2018.Now, there are some standards such as ASTM F3306-19 and ISO 10993 appeared. They should help us to control and analyze the Ni ion release from the implant medical devices. But all these standards are short of a solution that it can take the place of the complex simulated body solutions and blood, serum. Our aim is to discover the easy solution. It should make the evaluation of Ni release easy to do. Nickel-Titanium (NiTi) cardiovascular alloy products with registration certificate in National Medical Product Administration in China were chosen as samples in the investigation. In this study, C, H, N, O was measured by oxygen, nitrogen and hydrogen elements analyzer and mental element content was determined by Electron - coupled plasma atomic emission spectrometry (ICP-AES). While corrosion resistance was evaluated by electrochemistry. Ni release curves were plotted by measuring the amount of Ni released from seven extraction media. All the metallic and non-metallic content of samples were qualified with GB24627-2009. Wilcoxon Test showed that HCl was identified as a possible alternative to blood. The extraction medium was determined to be 10mL 0.005% HCl with a limit 50μg /d while time was 7 consecutive days with the temperature at 37°C.It was proved with a high degree of specificity and reliability. The evaluation guideline provides technical support for the review and regulatory authorities, and is of great significance in improving the quality and safety of such products, providing guidance for the standardized development of the Ni-Ti alloy cardiovascular product industry in China, with significant social benefits.
An expert consensus on prevention, diagnosis and management of hemorrhagic cystitis in pediatric hematopoietic cell transplantation, on behalf of the Infectious Disease and Hematopoietic Cell Transplant Working groups of Italian Pediatric Hematology Oncolo-gy Association (AIEOP)
Authors: Dell'Orso Gianluca , Carlucci Marcello , Cesaro Simone , Olcese Evelina , Balduzzi Adriana , Vendemini Francesca , Catti Massimo , Saglio Francesco , Compagno Francesca , Maximova Natalia , Rabusin Marco , Menconi Maria Cristina , Perruccio Katia , Soncini Elena , Tambaro Francesco Paolo , tintori Veronica , Pagliara Daria , Faraci Maura 
Published: March 2024

Abstract

The optimal management of hemorrhagic cystitis (HC) in hematopoietic stem cell transplantation (HCT) is debated, both for early onset HC (EOHC) secondary to chemotherapy toxicity and BK PolyomaVirus (BKPyV)-related HC, due to the lack of controlled trials, particularly referred to pediatric setting. Actually, clinical practice is mainly based on guidelines of European Conference on Infections in Leukemia, 6th edition, which consider both adult and pediatric population but conclude that, despite much progress in understanding the pathogenesis, epidemiology and risk factors, this complication still represents a disabling unmet clinical need with limited prophylactic and therapeutic options. Additionally, guidelines of American Society of Clinical Oncology define the management of chemotherapeutic toxicity independently from the patients’ population. A panel of experts belonging to the Hematopoietic Cell Transplant and Infectious Disease Working Group (WG) of Associazione Italiana di Emato-Oncologia Pediatrica (AIEOP) developed a consensus to define the best practices in prevention, diagnosis, and management of HC in pediatric HCT setting.
Suppression of AQP7 is Crucial for Proliferation and Lipid Metabolism in ccRCC
Authors: Zhao Jun , Wang Rui , Jin Jiacheng , Bi Yingwei , Chen Xue , Wang Jianbo 
Published: March 2024

Abstract
Background: It is well-established that reprogramming of lipid metabolism is a feature of clear cell renal cell carcinoma (ccRCC), which also acts as a driving force in oncogenesis induced by hypoxia-inducible factors (HIFs) in ccRCC. Aquaporin 7 (AQP7), a channel facilitates glycerol to pass through the membrane and induces a decrease in triglycerides (TGs) and glycerol in adipocytes. However, whether AQP7 takes a part in the lipid metabolism and malignant behaviors of ccRCC is still unclear.
Methods: The prognosis and diagnostic value of AQP7 in ccRCC were first evaluated by bioinformatics methods including TCGA database, Cox regression, etc. The expression of AQP7 was tested with tissue microarray and IHC. After AQP7 was stably upregulated by lentivirus transfection, cell viability, colony formation, and flow cytometry were performed. According to GSEA, Nile red staining was then used to detect lipid droplet accumulation, and relevant mechanisms and pathways were verified through Western blotting and qPCR.
Results: AQP7 was suppressed in both TCGA and the tissue microarray cohort, and the prognosis was worse for patients with lower AQP7 levels, including OS, DSS and PFI. Multiple lipid metabolism pathways, especially the PPARα pathway, were activated in the cohort with high AQP7 expression based on gene set enrichment analysis (GSEA). Moreover, AQP7 overexpression in ccRCC inhibited the proliferation ability, reduced the TG and glycerol contents, and led to cell cycle arrest. As a crucial transcription factor relevant to lipid metabolism, the ability of PPARα to bind to PPRE and the expression levels of PPARα, were both upregulated by AQP7 overexpression, as was the expression of a series of genes targeted by PPARα. Furthermore, downregulating HIF-1β and HIF-2α could elevate the expression levels of AQP7 and PPARα in ccRCC.
Conclusions: AQP7 is suppressed in ccRCC and AQP7 may be a promising prognostic marker for the disease. Suppression of AQP7 in ccRCC contributes to lipid metabolism and cell cycle acceleration. The HIF/AQP7/PPARα axis might be an avenue for ccRCC treatment targeting lipid metabolism.