bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of Formation of Migrant Residential Concentration Areas in the Context of a Postsocialist City: Evidence from Russia’s 15 Largest Cities
Authors: Varshaver Evgeni , Rocheva Anna , Ivanova Nataliya , Egorova Tatiana 
Published: February 2025

AbstractMigrant residential concentration areas have been a significant focus for research, but academic attention has primarily centered on their effects rather than how they form. There is some research considering the discrete factors of such areas’ emergence, but these factors are rarely fused into a comprehensive explanation with a description of specific mechanisms in operation. Even less is known about the formation of migrant residential concentration areas in postsocialist cities. The few studies in existence leave the impression that such areas emerge around bazaars by default. In this article, based on a multicase study (N = 37) conducted in the 15 largest Russian cities, we argue that although there is a pattern of migrant residential concentration areas’ emergence in postsocialist cities, this process takes place only in the presence of a combination of seven factors. The article presents these factors and describes an ideal type of a migrant residential concentration area in a Russian city and mechanisms of its emergence. The article concludes with the comparison of the postsocialist pattern with other types of migrant residential concentration and hypothesizing on how the Russian case differs from the other postsocialist cases in Central and Eastern Europe.
Politics, Identity and Civic Engagement: Comparing the Protest Participation of Ukrainian Migrants in the Home and Host Countries
Authors: Biletska Yuliya , Gherghina Sergiu 
Published: February 2025

Abstract
Migrant protest activity has been often analyzed from the perspectives of the protest nature and issues it addressed. A comparison of protest behaviour before and after migration is largely missing. It remains unclear whether people who were actively protesting in their home country continue to be engaged in protests after migration and why. This article addresses this gap in the literature and aims to explain what made the Ukrainian migrants protest before leaving their home country and in Turkey as a host country. The analysis uses individual data from an original survey conducted in May 2023 among 935 Ukrainian migrants living in Turkey. The findings show that there are different migrants who participate in the protests organized in the two countries, and the strongest predictor for political protest is civic engagement. Protest in Ukraine is rooted in the orientation towards domestic politics, while protests abroad are driven by identitarian dimensions.
Putting George Sand in Play from the Local Theatre to the Football Stadium
Authors: Dabbous Rayyan , Pizzolitto Dominic 
Published: February 2025

Abstract
This article explores the potential of public humanities to bridge the gap between academia and the public by performing the humanities in unconventional spaces. Through two case studies – adapting George Sand’s Indiana for a local theatre production and hosting an outreach booth at a football match for their Pride game – we demonstrate the value of engaging with the public, rather than presenting research to the public. By reflecting on these experiments, we discuss what it means to do the public humanities dialogically and what we learned from this process. Our experiments reveal that effective public humanities require collapsing the divide between academia and the public by meeting audiences where they are and fostering reciprocal learning. By integrating academic insights into popular contexts, we demonstrate how the humanities remain vital and relevant. These initiatives challenge traditional models of outreach, affirming the discipline’s role as a collaborative, dynamic field that thrives through active dialogue with diverse communities.
Persistent PTSD symptoms are associated with plasma metabolic alterations relevant to long-term health: A metabolome-wide investigation in women
Authors: Zhu Yiwen , Shutta Katherine H. , Huang Tianyi , Balasubramanian Raji , Zeleznik Oana A. , Clish Clary B. , Ávila-Pacheco Julián , Hankinson Susan E. , Kubzansky Laura D. 
Published: February 2025

Abstract

Background
Post-traumatic stress disorder (PTSD) is characterized by severe distress and associated with cardiometabolic diseases. Studies in military and clinical populations suggest that dysregulated metabolomic processes may be a key mechanism. Prior work identified and validated a metabolite-based distress score (MDS) linked with depression and anxiety and subsequent cardiometabolic diseases. Here, we assessed whether PTSD shares metabolic alterations with depression and anxiety and if additional metabolites are related to PTSD.

Methods
We leveraged plasma metabolomics data from three subsamples nested within the Nurses’ Health Study II, including 2835 women with 2950 blood samples collected across three time points (1996–2014) and 339 known metabolites assayed by mass spectrometry-based techniques. Trauma and PTSD exposures were assessed in 2008 and characterized as follows: lifetime trauma without PTSD, lifetime PTSD in remission, and persistent PTSD symptoms. Associations between the exposures and the MDS or individual metabolites were estimated within each subsample adjusting for potential confounders and combined in random-effects meta-analyses.

Results
Persistent PTSD symptoms were associated with higher levels of the previously developed MDS. Out of 339 metabolites, we identified 29 metabolites (primarily elevated glycerophospholipids and glycerolipids) associated with persistent symptoms (false discovery rate < 0.05; adjusting for technical covariates). No metabolite associations were found with the other PTSD-related exposures.

Conclusions
As the first large-scale, population-based metabolomics analysis of PTSD, our study highlighted shared and distinct metabolic differences linked to PTSD versus depression or anxiety. We identified novel metabolite markers associated with PTSD symptom persistence, suggesting further connections with metabolic dysregulation that may have downstream consequences for health.
Changes in glutamate levels in anterior cingulate cortex following 16 weeks of antipsychotic treatment in antipsychotic-naïve first-episode psychosis patients
Authors: Maximo Jose , Nelson Eric , Kraguljac Nina , Patton Rita , Bashir Adil , Lahti Adrienne 
Published: February 2025

Abstract

Background
Previous findings in psychosis have revealed mixed findings on glutamate (Glu) levels in the dorsal anterior cingulate cortex (dACC). Factors such as illness chronicity, methodology, and medication status have impeded a more nuanced evaluation of Glu in psychosis. The goal of this longitudinal neuroimaging study was to investigate the role of antipsychotics on Glu in the dACC in antipsychotic-naïve first-episode psychosis (FEP) patients.

Methods
We enrolled 117 healthy controls (HCs) and 113 antipsychotic-naïve FEP patients for this study. 3T proton magnetic resonance spectroscopy (1H-MRS; PRESS; TE = 80 ms) data from a voxel prescribed in the dACC were collected from all participants at baseline, 6, and 16 weeks following antipsychotic treatment. Glutamate levels were quantified using the QUEST algorithm and analyzed longitudinally using linear mixed-effects models.

Results
We found that baseline dACC glutamate levels in FEP were not significantly different than those of HCs. Examining Glu levels in FEP revealed a decrease in Glu levels after 16 weeks of antipsychotic treatment; this effect was weaker in HC. Finally, baseline Glu levels were associated with decreases in positive symptomology.

Conclusions
We report a progressive decrease of Glu levels over a period of 16 weeks after initiation of treatment and a baseline Glu level association with a reduction in positive symptomology, suggestive of a potential mechanism of antipsychotic drug (APD) action. Overall, these findings suggest that APDs can influence Glu within a period of 16 weeks, which has been deemed as an optimal window for symptom alleviation using APDs.
Worship and the problems of human evil and suffering
Authors: Conklin Sherri Lynn , Hassoun Nicole 
Published: February 2025

Abstract
Consider a simple argument that worshipping God is wrong. This world is not a nice place. Not only do humans persecute and inflict other evils on each other, but millions of people suffer and die every year from preventable poverty-related causes, and it seems that few, if any, deserve their plights. It is unclear that we should want to be associated with, never mind worship, a being with the capacity to make the world a much better place but whose beneficence (or knowledge) permits things to go on in the ways that they do. At first blush, contempt is a more fitting response to God than worship. But, assuming God exists, perhaps we have reason to accept, if not worship, him in any case. Humans are comparably limited. We do evil unto each other, and, insofar as millions of deaths are preventable, our failure to prevent them is a failure of humans as well as of God. If we could (and should) have saved many lives and have not, our moral failings present us with our own, human, problem of evil and suffering. So, if we should reject God because so many people suffer, then we should reject ourselves when we could avoid evil and help others too. However, this article argues that we have practical, moral, and epistemic reasons to accept rather than reject ourselves, and similarly we have reasons to accept God. And if we have reason to accept God, then we have some reason to worship God. Worship is a way of acknowledging our own limitations and can help us survive, flourish, and help others in the face of the problems of human evil and suffering.
Is the cosmological argument intuitive?
Authors: Nichols Shaun , Steinberg Justin 
Published: February 2025

Abstract
The cosmological argument for the existence of God seems to have significant intuitive resonance. According to a familiar version of the cosmological argument, there must be some explanation for why the universe exists, and God provides the explanation. This argument seems to depend on the Principle of Sufficient Reason (PSR), according to which, if something exists, there must be an explanation for why it exists. As we detail, recent evidence indicates that people presuppose something like the PSR in their explanatory outlook. However, the other key part of the cosmological argument is that God is supposed to be self-explanatory – God’s existence is necessary. We examine this empirically and find that people do not generally think that the existence of God is necessary in the sense relevant for the cosmological argument.
Chemotypic variation in niloticin, psoralen, quercetin and stigmasterol in wood apple (Limonia acidissima L.) leaves
Authors: Lata Annu , Kumar Abhishek , Chand Jai , Yadav Hemant Kumar , Nair Narayanan K. , Pal Mahesh 
Published: February 2025

Abstract
Wood apple (Limonia acidissima L., Rutaceae) is a medium to large-sized semideciduous tree native to Indian subcontinent. The Indian systems of medicine recognized this tree for its medicinal properties and nutritional fruit. The present study evaluates chemotypic diversity by using HPTLC method for identification of elite genotypes among 96 accessions of wood apple leaves collected from diverse populations across 16 states of India. Here, the multivariate analysis, including the extent of variation, broad sense heritability, genetic advance, correlation of mean value of each replicate were assessed with respect to four target bioactive molecules (quercetin, stigmasterol, psoralen and niloticin) extracted from leaves of wood apple. The results showed that the analysis of variance revealed significant variabilities for all the four biomolecules analysed. The hierarchical clustering grouped all the accessions into eight clusters. Out of which, cluster II and VI contained a maximum of 20 and 18 genotypes, respectively. Cluster VIII consisted of only three genotypes. The intra-cluster distance ranged from 0 (cluster II to VIII) to 6.83 (cluster I). The highest inter-cluster distance was found between clusters V and VII (22.52). Positive correlation was found between chemotypic traits at both the genotypic and phenotypic level. The broad sense heritability was recorded highest for quercetin (97.7%). The high genetic advance was noticed for niloticin (217.4). This study detected significant chemotypic variation among the accessions. The elite accessions identified in this study could be utilized to enhance the quality, efficacy and economic value of medicinal products.
Heterotic grouping of maize (Zea mays L.) inbreds derived from diverse indigenous landraces of the Northeast Hill Region of India
Authors: Rajasekhar Duddukur , KL Naveenkumar , Kalita Samudra , Tatiparthi Harshavardhan , Rai Mayank , Sen Devyani 
Published: February 2025

Abstract
The present study aimed to utilize maize landraces from the North Eastern Hill Region (NEHR) of India for hybrid development, addressing the absence of established heterotic groups for maize in this region. Eighty inbreds derived from diverse local landraces were test-crossed to two testers LM-13 and LM-14. The 160 testcrosses were evaluated over two seasons using an alpha lattice design. Heterotic grouping studies utilizing BLUP values, included analyses of specific combining ability (SCA), specific and general combining ability (HSGCA), and GCA of multiple traits (HGCAMT). Additionally, 34 SSR markers were employed to group the inbreds based on genetic distance (SSR_GD). Breeding efficiency tests indicated that the conventional SCA and HSGCA methods were the most effective for heterotic grouping, enabling classification of the overlapping inbreds into the corresponding tester groups. Validation involving 10 inbreds – 5 from each tester group crossed in a full diallel fashion – revealed that gene action was predominantly non-additive, a prerequisite for heterosis breeding. The highest-performing hybrids exhibited better parent heterosis (BPH) ranging from 75 to 384%, demonstrating significant yield advantages. These hybrids combined moderately divergent parents with contrasting female and male GCA values and BPH was significantly associated with SCA effects, providing predictive insights for optimizing hybrid development. The findings of this study highlight the potential of NEHR germplasm for developing high-yielding hybrids tailored to local conditions. These hybrids would particularly benefit smallholding farmers practicing shifting cultivation by enabling cost-effective production and providing economic benefits.
Viet Nam’s Dynamic Approach to Lawfare
Authors: NGUYEN Tien-Duc 
Published: February 2025

Abstract
This article reviews the emergence of “lawfare” as a term in vogue in recent years. Despite its complexity, lawfare is widely used by scholars and policy-makers in a disparaging and polemical sense. Efforts have been made to attribute a neutral tone to the term with a clearer analytical framework. Taking Viet Nam and the South China Sea disputes as an illustration, the article probes whether and how a small, peripheral country works out a lawfare strategy. It finds that Viet Nam has employed elements of lawfare strategy to counter China’s expansionist claims at sea by recalibrating its national interests and legal positions over time. Lawfare is a long game, yet it holds out hope for Viet Nam, a peripheral country, amidst intense superpower rivalry.
Dynamic Tolerance: Tolerance within Nahdlatul Ulama and Nahdliyin in Indonesia
Authors: Budiatri Aisah Putri 
Published: February 2025

Abstract
Nahdlatul Ulama (NU), the world’s largest Islamic organisation, is renowned for fostering tolerance in Indonesia. However, recent studies have revealed that the degrees of tolerance NU displays are inconsistent, throwing the organisation’s reputation for acceptance into question. By adopting critical juncture and case study analyses, this article finds that tolerance within NU is dynamic for three reasons. First, it evolves depending on the social-political context of the time. Second, NU upholds tolerance within specific limits, extending it to those who do not contradict the Islamic values it upholds and who do not pose a threat to the unitary state of the Republic of Indonesia (NKRI). Third, the commitment to tolerance by NU’s membership, the nahdliyin, varies and does not always align with NU’s principles.
Predicting maize yield loss with crop-weed leaf cover ratios determined with UAS imagery
Authors: Goldsmith Avi , Austin Robert , Cahoon Charles W. , Leon Ramon G. 
Published: February 2025

Abstract
Typically, weed density is used to predict weed-induced yield loss, as it is easy and quick to quantify, even though it does not account for weed size and time of emergence relative to the crop. Weed-crop leaf area relations, while more difficult to measure, inherently account for differences in plant size, representing weed-crop interference more accurately than weed density alone. Unmanned aerial systems (UAS) may allow for efficient quantification of weed and crop leaf cover over a large scale. It was hypothesized that UAS imagery could be used to predict maize yield loss based on weed-crop leaf cover ratios. A yield loss model for maize (Zea mays L.) was evaluated for accuracy using 15- and 30-m altitude aerial RGB and four-band multispectral imagery collected at four North Carolina locations. The model consistently over and underpredicted yield loss when observed yield loss was less than and greater than 3000 kg ha-1, respectively. Altitude and sensor type did not influence the accuracy of the prediction. A correction for the differences between predicted and observed yield loss was incorporated into the linear model to improve overall precision. The correction resulted in r2 increasing from 0.17 to 0.97 and a reduction in RMSE from 705 kg ha-1 to 219 kg ha-1. The results indicated that UAS images can be used to develop predictive models for weed-induced yield loss prior to canopy closure, making it possible for growers to plan production and financial decisions before the end of the growing season.
Targeting CDK4/6 in breast cancer
Authors: Shanabag Anusha , Armand Jessica , Son Eugene , Yang Hee Won 
Published: February 2025

Abstract
Dysregulation of the cell cycle machinery, particularly the overactivation of cyclin-dependent kinases 4 and 6 (CDK4/6), is a hallmark of breast cancer pathogenesis. The introduction of CDK4/6 inhibitors has transformed the treatment landscape for hormone receptor-positive breast cancer by effectively targeting abnormal cell cycle progression. However, despite their initial clinical success, drug resistance remains a significant challenge, with no reliable biomarkers available to predict treatment response or guide strategies for managing resistant populations. Consequently, numerous studies have sought to investigate the mechanisms driving resistance to optimize the therapeutic use of CDK4/6 inhibitors and improve patient outcomes. Here we examine the molecular mechanisms regulating the cell cycle, current clinical applications of CDK4/6 inhibitors in breast cancer, and key mechanisms contributing to drug resistance. Furthermore, we discuss emerging predictive biomarkers and highlight potential directions for overcoming resistance and enhancing therapeutic efficacy.
High-performance, multi-component epoxy resin simulation for predicting thermo-mechanical property evolution during curing
Authors: Patil Sagar Umesh , Kemppainen Josh , Maiaru Marianna , Odegard Gregory M. 
Published: February 2025

Abstract
High-performance epoxy systems are extensively used in structural polymer‒matrix composites for aerospace vehicles. The evolution of the thermomechanical properties of these epoxies significantly impacts the evolution of process-induced residual stresses. The corresponding process parameters need to be optimized via multiscale process modeling to minimize the residual stresses and maximize the composite strength and durability. In this study, the thermomechanical properties of a multicomponent epoxy system are predicted via molecular dynamics (MD) simulation as a function of the degree of cure to provide critical property evolution data for process modeling. In addition, the experimentally validated results of this study provide critical insight into MD modeling protocols. Among these insights, harmonic- and Morse-bond-based force fields predict similar mechanical properties. However, simulations with the Morse-bond potential fail at intermediate strain values because of cross-term energy dominance. Additionally, crosslinking simulations should be conducted at the corresponding processing temperature, because the simulation temperature impacts shrinkage evolution significantly. Multiple analysis methods are utilized to process MD heating/cooling data for glass transition temperature prediction, and the results indicate that neither method has a significant advantage. These results are important for effective and comprehensive process modeling within the ICME (Integrated Computational Materials Engineering) and Materials Genome Initiative frameworks.
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV
Authors: Newton Lydia S. , Gathmann Clara , Ridewood Sophie , Smith Robert J. , Wijaya Andre J. , Hornsby Thomas W. , Morling Kate L. , Annett Dara , Chiozzi Riccardo Zenezini , Reuschl Ann-Kathrin , Govasli Morten L. , Tan Ying Ying , Thorne Lucy G. , Jolly Clare , Thalassinos Konstantinos , Ciulli Alessio , Towers Greg J. , Selwood David L. 
Published: February 2025

Abstract
Targeting host proteins that are crucial for viral replication offers a promising antiviral strategy. We have designed and characterised antiviral PROteolysis TArgeting Chimeras (PROTACs) targeting the human protein cyclophilin A (CypA), a host cofactor for unrelated viruses including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). The PROTAC warheads are based on fully synthetic macrocycles derived from sanglifehrin A, which are structurally different from the classical Cyp inhibitor, cyclosporine A. Our Cyp-PROTACs decrease CypA levels in cell lines and primary human cells and have high specificity for CypA confirmed by proteomics experiments. Critically, CypA degradation facilitates improved antiviral activity against HIV-1 in primary human CD4+ T cells compared to the non-PROTAC parental inhibitor, at limiting inhibitor concentrations. Similarly, we observe antiviral activity against HCV replicon in a hepatoma cell line. We propose that CypA-targeting PROTACs inhibit viral replication potently and anticipate reduced evolution of viral resistance and broad efficacy against unrelated viruses. Furthermore, they provide powerful tools for probing cyclophilin biology.