bluuebunny/crossref_metadata_2025_split huggingface dataset:
The GOES-R Advanced Baseline Imager and the Continuation of Current Sounder Products
Authors: Schmit Timothy J. , Li Jun , Li Jinlong , Feltz Wayne F. , Gurka James J. , Goldberg Mitchell D. , Schrab Kevin J. 
Published: March 2008

Abstract
The first of the next-generation series of Geostationary Operational Environmental Satellites (GOES-R) is scheduled for launch in the 2015 time frame. One of the primary instruments on GOES-R, the Advanced Baseline Imager (ABI), will offer more spectral bands, higher spatial resolution, and faster imaging than does the current GOES Imager. Measurements from the ABI will be used for a wide range of qualitative and quantitative weather, land, ocean, cryosphere, environmental, and climate applications. However, the first and, likely, the second of the new series of GOES will not carry an infrared sounder dedicated to acquiring high-vertical-resolution atmospheric temperature and humidity profiles that are key to mesoscale and regional severe-weather forecasting. The ABI will provide some continuity of the current sounder products to bridge the gap until the advent of the GOES advanced infrared sounder. Both theoretical analysis and retrieval simulations show that data from the ABI can be combined with temperature and moisture information from forecast models to produce derived products that will be adequate substitutes for the legacy products from the current GOES sounders. Products generated from the Spinning Enhanced Visible and Infrared Imager (SEVIRI) measurements also demonstrate the utility of those legacy products for nowcasting applications. However, because of very coarse vertical resolution and limited accuracy in the legacy sounding products, placing a hyperspectral-resolution infrared sounder with high temporal resolution on future GOES is an essential step toward realizing substantial improvements in mesoscale and severe-weather forecasting required by the user communities.
Interstate Reciprocity in Teacher Education-Certification
Authors: Stinnett T.M. , Bowers Harold J. , Robert E.B. 
Published: March 2008

Encouraging progress is being made toward the free movement of qualified teachers across state lines, as revealed by the study reported here. Three of the nation's best informed students of the reciprocity problem have collaborated in the preparation of the report. Mr. Stin nett is associate secretary of the National Commission on Teacher Education and Professional Standards. Mr. Bowers, su pervisor of the Division of Teacher Edu cation, Ohio State Department of Educa tion, is president of the National Asso ciation of State Directors of Teacher Education and Certification. Mr. Robert, dean of the School of Education, Louisi ana State University, is president of the Southern Association of Colleges and Sec ondary Schools. This is the first of a series of Commis sion Studies in Teacher Education which will have their original publication in regular issues of THE JOURNAL OF TEACHER EDUCATION from time to time. Reprints of this report are available at cost to JOUR NAL subscribers.
Facts Revealed By the 1951 Study of Teacher Supply and Demand
Authors: Maul Ray C. 
Published: March 2008

Here is a brief summary of the 1951 study of teacher supply and demand, an investigation conducted annually under the sponsorship of the National Commis sion on Teacher Education and Profes sional Standards. It provides a background against which trends may be seen, com parisons may be made, progress meas ured, and a sharper view of unsolved problems obtained. Not only professional workers in all aspects of teacher educa tion, but teachers throughout the nation, students in the various stages of prepara tion, and those yet to choose teaching as an occupation need information of the kind revealed by this type of inquiry. Mr. Maul, the director, serves as Research As sociate of the National Commission. He is on leave of absence from his adminis trative duties at State Teachers College, Emporia, Kansas, for full-time service at the National Education Association head- quarters. Copies of the complete 36-page report containing state-by-state figures on supply, demand, preparation of elementary-school teachers, and live births may be obtained froan the office of the Commission, 1201 Sixteenth Street, Northwest, Washington 6, D. C., for $1.00 each.
Patterns of Cooperation in Administering State Teacher-Education and Certification Programs
Authors: Stinnett T.M. , Umstattd J.G. 
Published: March 2008

Cooperative processes are basic to edu cation in a democracy. They are, however, not necessarily inherent. Like any other worth-while achievement in the area of self-determination, they must be planned for and worked for. Too often lip service is given to the democratic process in edu cation, while the easier method of indi vidual decision is followed. The accom panying article describes the efforts, through advisory councils on teacher edu cation and certification, of state depart ments of education to provide democratic and cooperative means of exercising the legal authority delegated to them by state legislatures regarding teacher educa tion and certification. Further, the article describes the work of state education as sociations, through commissions on teach er education and professional standards, to enlist the full membership of the teach ing profession in the study of standards and in recommendations to the state legal authority regarding desirable action pro grams. The authors have had long interest in and experience with both procedures. Mr. Umstattd is Chairman of the Department of Curriculum and Instruction, College of Education, University of Texas, Austin. He has served on a number of committees of the Southern Association of Colleges and Secondary Schools, and in 1950 was the president of the National Association of College Teachers of Education. Mr. Stinnett, now Executive Secretary of the National Commission on Teacher Educa tion and Professional Standards, served for nearly a decade as State Director of Teacher Education and Certification in Arkansas and has worked intensively with both advisory councils and state commis sions.
Browsing Through the Bookshelves
Authors: McCuskey Dorothy 
Published: March 2008

This column is conducted regularly by Miss McCuskey and all unsigned reviews are by her. Names of other reviewers are placed at the end of their reviews. Books for review may be sent to Miss McCuskey at the School of Education, University of North Carolina, Chapel Hill. It will not, however, be possible to review all unsolicited material. Choice of ma terial for review is made on the criteria of possible use in teacher-education insti tutions and field-training programs.
The Ford Foundation-Arkansas Experiment
Authors: Clarke C.M. 
Published: March 2008

The accompanying article describes the plan which has been agreed upon between the school people in Arkansas and the Fund for the Advancement of Education of The Ford Foundation. It summarizes the reconcilement of what originally de veloped as a highly controversial proposal. First announcements of the proposal, widely publicized in the press, caused extreme speculation and apprehension among teacher-education personnel throughout the country. These announce ments rather categorically and, it seemed from this distance, rather confidently stated that all professional courses in the first four years were to be eliminated, the two state teachers colleges abolished, as such, and transformed into liberal-arts col leges. The inference was that a predeter mined plan of teacher education, unsup ported by any valid evidence of superiority over the old, was to be imposed on a state school system. The furor raised by these unfortunate statements was reflected in a resolution denouncing the plan, adopted by the AACTE at its annual meeting in Chicago last February. Fortunately, school personnel in Arkan sas calmly and judiciously sought sound answers to questions raised by the pro posal. They refused to be stampeded by newspaper and public pressures or the lure of grants. A year of intensive study has resulted in a meeting of minds and the adoption of an experimental program which will parallel the present one. If valid evaluative techniques are used, a great service could be rendered teacher education by providing evidence of the relative merits of this plan as contrasted with another. Without such evidence, skepticism may justifiably continue con cerning the wisdom of telescoping profes sional preparation into the fifth year. C. M. Clarke is Director of the Division of Teacher Education and Certification, Arkansas State Department of Education. He will serve as Chairman of the Execu tive Committee which will direct the project.
An Annotated Bibliography On Teacher Recruitment, Supply, and Demand
Authors: Eliassen R.H. 
Published: March 2008

Out of long familiarity with this field, Mr. Eliassen, Chairman of the Graduate Division, East Tennessee State College, was requested to prepare this important bibliography. He selected and annotated the references with a view to their value for Persons interested in problems of staffing the school systems of our nation. Recent works predominate, but a few earlier studies are included because of their unusual techniques or sig nificance. Mr. Eliassen writes that these references are typical of hundreds which are available and which are deserving of attention and study. Those listed here, however, provide a substantial nucleus both for gaining a current view of the problem and for beginning a more extended study.—Douglas E. Scates, Editor.
Cooperative Study To Predict Effectiveness in Secondary School Teaching
Authors: Scates Douglas E. , Hedlund Paul A. 
Published: March 2008

The characteristic, and heartening, aspect of the present trend in the study of teaching effectiveness is that researchers are actually gathering data on complex qualities and traits which earlier generations thought could be dealt with only by personal impression and judgment. This is not to promise that each study which is undertaken will yield the coveted answer; but it means that the present period is making courageous and effective contributions to the forward movement of educational science. It is through the accumulation of data, insights, and understanding over several hundred years that the physical sciences have achieved their status of great serviceability. Likewise, educa tional science, through continued pioneering effort, will carry us to unbelievable levels of accomplishment. It is the policy of this research section to bring to the attention of its readers studies which are helping to build the outlines of this progress. The present study is still continuing; but knowing its structure may help others to get research studies along similar lines started.—Douglas E. Scates.
The Choice of a Vocation
Authors: Jordaan Jean Pierre 
Published: March 2008

Any discussion of selective recruitment of students for teacher education must turn upon a number of assumptions re garding the way in which young people make vocational choices. In this article, Dr. Jordaan reviews current research re garding the choice of a vocation and of fers a summary of our present knowledge of the subject. He argues that vocational "development" is a better term than "choice" because "Every vocational deci sion has a history.... The final decision ... is the result of a process stretching over many years." The author is Visiting Assistant Pro fessor of Education in Teachers College, Columbia University.
Selective Admissions and Retention Practices in Teacher Education
Authors: Stout Ruth A. 
Published: March 2008

The article which begins on this page is the fourth in a series of significant studies in teacher education published in the Journal of Teacher Education since March, 1950, under the general title, "Commission Studies in Teacher Education." It is a condensation of Dr. Stout's dissertation submitted to the University of Minnesota in June of this year. The study was jointly sponsored by the American Associa tion of Colleges for Teacher Education and the National Commission on Teacher Educa tion and Professional Standards. Since joining the Kansas State Teachers Association staff in 1953 Dr. Stout, as Director of Field Programs, has handled educational planning and research. Most of her time is devoted to college relations, selective recruitment, and improved certification and prepara tion standards. Her record of professional service includes the following: chairman. NCTEPS, 1955 (member, 1949-55); president, KSTA, 1947; member, North Central Association Liberal Arts Study Committee, 1950, 1951; member, AACTE Committee on Studies, 1952-57; member, Kansas Advisory Council on Teacher Education, 1947-present; chairman, Kansas Commission on Teacher Education and Professional Standards, 1949- 53 ; and first vice-president, National Education Association, 1957-58. This record of service has ably qualified her for the preparation of this important study which is national in scope. Parts I and II of the study appear in this issue; parts III and IV will be published in the December, 1957, issue of the Journal.—THE EDITORS.
An exploration of the experiences of South Asian students on Pre-registration nursing programmes in a UK university
Authors: Dyson Sue , Culley Lorraine , Norrie Peter , Genders Nicky 
Published: March 2008

Abstract There is a lack of focused research on the educational experience of minority ethnic nursing students in the United Kingdom. This small scale mixed–method study has shown that in one institution, South Asian students entered training at a younger age than White students but had broadly similar levels of attainment and completion. Qualitative data suggest that although South Asian and White students share many common experiences, the cultural background of South Asian students may have a considerable effect on their academic life, sometimes creating particular tensions and difficulties. Several themes are explored, including choosing nursing, negotiating marriage, responding to family obligations, relating to fellow students and accessing support. Students expressed the importance of peer group and personal tutor support to their academic success. Understanding the student experience is important and should help institutions to develop culturally sensitive support systems.
Chromhome: A rich internet application for accessing comparative chromosome homology maps
Authors: Nagarajan Sridevi , Rens Willem , Stalker James , Cox Tony , Ferguson-Smith Malcolm A 
Published: March 2008

Abstract

Background
Comparative genomics has become a significant research area in recent years, following the availability of a number of sequenced genomes. The comparison of genomes is of great importance in the analysis of functionally important genome regions. It can also be used to understand the phylogenetic relationships of species and the mechanisms leading to rearrangement of karyotypes during evolution. Many species have been studied at the cytogenetic level by cross species chromosome painting. With the large amount of such information, it has become vital to computerize the data and make them accessible worldwide. Chromhome http://www.chromhome.org is a comprehensive web application that is designed to provide cytogenetic comparisons among species and to fulfil this need.

Results
The Chromhome application architecture is multi-tiered with an interactive client layer, business logic and database layers. Enterprise java platform with open source framework OpenLaszlo is used to implement the Rich Internet Chromhome Application. Cross species comparative mapping raw data are collected and the processed information is stored into MySQL Chromhome database. Chromhome Release 1.0 contains 109 homology maps from 51 species. The data cover species from 14 orders and 30 families. The homology map displays all the chromosomes of the compared species as one image, making comparisons among species easier. Inferred data also provides maps of homologous regions that could serve as a guideline for researchers involved in phylogenetic or evolution based studies.

Conclusion
Chromhome provides a useful resource for comparative genomics, holding graphical homology maps of a wide range of species. It brings together cytogenetic data of many genomes under one roof. Inferred painting can often determine the chromosomal homologous regions between two species, if each has been compared with a common third species. Inferred painting greatly reduces the need to map entire genomes and helps focus only on relevant regions of the chromosomes of the species under study. Future releases of Chromhome will accommodate more species and their respective gene and BAC maps, in addition to chromosome painting data. Chromhome application provides a single-page interface (SPI) with desktop style layout, delivering a better and richer user experience.
Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells
Authors: Mutarelli Margherita , Cicatiello Luigi , Ferraro Lorenzo , Grober Olì MV , Ravo Maria , Facchiano Angelo M , Angelini Claudia , Weisz Alessandro 
Published: March 2008

Abstract

Background
Microarray experiments enable simultaneous measurement of the expression levels of virtually all transcripts present in cells, thereby providing a ‘molecular picture’ of the cell state. On the other hand, the genomic responses to a pharmacological or hormonal stimulus are dynamic molecular processes, where time influences gene activity and expression. The potential use of the statistical analysis of microarray data in time series has not been fully exploited so far, due to the fact that only few methods are available which take into proper account temporal relationships between samples.

Results
We compared here four different methods to analyze data derived from a time course mRNA expression profiling experiment which consisted in the study of the effects of estrogen on hormone-responsive human breast cancer cells. Gene expression was monitored with the innovative Illumina BeadArray platform, which includes an average of 30-40 replicates for each probe sequence randomly distributed on the chip surface. We present and discuss the results obtained by applying to these datasets different statistical methods for serial gene expression analysis. The influence of the normalization algorithm applied on data and of different parameter or threshold choices for the selection of differentially expressed transcripts has also been evaluated. In most cases, the selection was found fairly robust with respect to changes in parameters and type of normalization. We then identified which genes showed an expression profile significantly affected by the hormonal treatment over time. The final list of differentially expressed genes underwent cluster analysis of functional type, to identify groups of genes with similar regulation dynamics.

Conclusions
Several methods for processing time series gene expression data are presented, including evaluation of benefits and drawbacks of the different methods applied. The resulting protocol for data analysis was applied to characterization of the gene expression changes induced by estrogen in human breast cancer ZR-75.1 cells over an entire cell cycle.
A three-state prediction of single point mutations on protein stability changes
Authors: Capriotti Emidio , Fariselli Piero , Rossi Ivan , Casadio Rita 
Published: March 2008

Abstract

Background
A basic question of protein structural studies is to which extent mutations affect the stability. This question may be addressed starting from sequence and/or from structure. In proteomics and genomics studies prediction of protein stability free energy change (ΔΔG) upon single point mutation may also help the annotation process. The experimental ΔΔG values are affected by uncertainty as measured by standard deviations. Most of the ΔΔG values are nearly zero (about 32% of the ΔΔG data set ranges from −0.5 to 0.5 kcal/mole) and both the value and sign of ΔΔG may be either positive or negative for the same mutation blurring the relationship among mutations and expected ΔΔG value. In order to overcome this problem we describe a new predictor that discriminates between 3 mutation classes: destabilizing mutations (ΔΔG<−1.0 kcal/mol), stabilizing mutations (ΔΔG>1.0 kcal/mole) and neutral mutations (−1.0≤ΔΔG≤1.0 kcal/mole).

Results
In this paper a support vector machine starting from the protein sequence or structure discriminates between stabilizing, destabilizing and neutral mutations. We rank all the possible substitutions according to a three state classification system and show that the overall accuracy of our predictor is as high as 56% when performed starting from sequence information and 61% when the protein structure is available, with a mean value correlation coefficient of 0.27 and 0.35, respectively. These values are about 20 points per cent higher than those of a random predictor.

Conclusions
Our method improves the quality of the prediction of the free energy change due to single point protein mutations by adopting a hypothesis of thermodynamic reversibility of the existing experimental data. By this we both recast the thermodynamic symmetry of the problem and balance the distribution of the available experimental measurements of free energy changes. This eliminates possible overestimations of the previously described methods trained on an unbalanced data set comprising a number of destabilizing mutations higher than stabilizing ones.
In silico docking of urokinase plasminogen activator and integrins
Authors: Degryse Bernard , Fernandez-Recio Juan , Citro Valentina , Blasi Francescol , Cubellis Maria Vittoria 
Published: March 2008

Abstract

Background
Urokinase, its receptor and the integrins are functionally associated and involved in regulation of cell signaling, migration, adhesion and proliferation. No structural information is available on this potential multimolecular complex. However, the tri-dimensional structure of urokinase, urokinase receptor and integrins is known.

Results
We have modeled the interaction of urokinase on two integrins, αIIbβ3 in the open configuration and αvβ3 in the closed configuration. We have found that multiple lowest energy solutions point to an interaction of the kringle domain of uPA at the boundary between α and β chains on the surface of the integrins. This region is not far away from peptides that have been previously shown to have a biological role in urokinase receptor/integrins dependent signaling.

Conclusions
We demonstrated that in silico docking experiments can be successfully carried out to identify the binding mode of the kringle domain of urokinase on the scaffold of integrins in the open and closed conformation. Importantly we found that the binding mode was the same on different integrins and in both configurations. To get a molecular view of the system is a prerequisite to unravel the complex protein-protein interactions underlying urokinase/urokinase receptor/integrin mediated cell motility, adhesion and proliferation and to design rational in vitro experiments.