bluuebunny/crossref_metadata_2025_split huggingface dataset:
CDKN2A common variant and multi‐organ cancer risk—a population‐based study
Authors: Dębniak Tadeusz , Scott Rodney J. , Huzarski Tomasz , Byrski Tomasz , Rozmiarek Andrzej , Dębniak Boguslaw , Górski Bohdan , Cybulski Cezary , Mędrek Krzysztof , Mierzejewski Marek , Masojc Bartłomiej , Matyjasik Joanna , Złowocka Elzbieta , Teodorczyk Urszula , Lener Marcin , Klujszo‐Grabowska Ewa , Nej‐Wołosiak Katarzyna , Jaworowska Ewa , Oszutowska Dorota , Szymańska Anna , Szymańska Jolanta , Castaneda Jennifer , van de Wetering Thierry , Suchy Janina , Kurzawski Grzegorz , Oszurek Oleg , Narod Steven , Lubinski Jan 
Published: January 2006

AbstractThe population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a common variant of the CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it is significantly overrepresented among Polish melanoma patients when compared to general population. Herein, we ascertained the prevalence of the A148T variant in 3,583 unselected cancer cases and 3,000 random control subjects from the same Polish population. We evaluated eleven different malignancies, representing the majority of all common cancer sites. Positive association with A148T variant was observed for lung cancer (OR, 2.0; p = 0.0052). A similar trend, although nonsignificant after the Bonferroni correction, was observed for colorectal cancer (OR, 1.5; p = 0.5499). These results suggest that A148T variant may be associated with a multi‐organ cancer risk in the Polish population. © 2006 Wiley‐Liss, Inc.
Cancer‐associated carbohydrate identification in Hodgkin's lymphoma by carbohydrate array profiling
Authors: Lawrie Charles H. , Marafioti Teresa , Hatton Christian S.R. , Dirnhofer Stephan , Roncador Giovanna , Went Philip , Tzankov Alexandar , Pileri Stefano A. , Pulford Karen , Banham Alison H. 
Published: January 2006

AbstractTumor‐associated carbohydrates have potential not only as diagnostic tools but also as specific therapeutic targets. Their identification, however, has been hampered by the lack of suitable technologies. We used carbohydrate array technology to compare serum antibody (IgG and IgM) levels against 37 different carbohydrates between classical Hodgkin's lymphoma (cHL) patients and age/sex‐matched healthy controls. Serum IgM levels measured by ELISA against 2 of the 5 carbohydrates identified using this technique, L‐α‐arabinose (L‐Araf) and α‐N‐acetylgalactosamine (GalNAc(α)), were higher (F values of 11.30 and 18.27, respectively) in a cohort of cHL patients (n = 16) than either diffuse large B‐cell lymphoma patients (n = 18) or control sera (n = 12). Higher anti‐L‐Araf IgM levels in cHL patients were associated with cytosine arabinoside treatment (p < 0.05). The GalNAc(α) glycotope, Tn, was found to be heterogeneously expressed in the Reed‐Sternberg cells of 9/20 (45%) cHL cases, but not in malignant cells of 25 cases of lymphocyte‐predominant HL or another 21 hematological disorders (291 cases) examined immunohistochemically. Tn was expressed in 41/238 (17%) classical HL cases present on a tissue microarray. Expression was associated with CD79a and LMP1 expression and negatively with p27KIP1 expression (p < 0.05). Kaplan‐Meier survival analysis revealed a trend towards improved relapse‐free survival with Tn expression although this was not statistically significant (p = 0.271). We suggest that this technique could provide a powerful tool for identifying novel carbohydrates in other cancers. © 2006 Wiley‐Liss, Inc.
Valuations of glued near hexagons
Authors: De Bruyn Bart 
Published: January 2006

AbstractValuations of near polygons were introduced in [12] as an important tool for classifying dense near polygons. In the present article, we will introduce the class of the semi‐diagonal valuations. These valuations live in glued near hexagons. A glued near hexagon S can be coordinatized by a pair of admissible triples; such triples consist of a Steiner system ${\cal L}$, a group G, and a certain nice map $\Delta :{\cal L} \times {\cal L} \to G$. We will give a necessary and sufficient condition for the existence of semi‐diagonal valuations in ${\cal S}$ in terms of these two admissible triples. For two classes of glued near hexagons, we will use this condition to determine all semi‐diagonal valuations. Each semi‐diagonal valuation will also give rise to a hyperplane of the glued near hexagon. © 2006 Wiley Periodicals, Inc. J Combin Designs 15: 35–48, 2007
Expressing the equivalence of non‐isothermal and isothermal heat sterilization processes
Authors: Corradini Maria G , Normand Mark D , Peleg Micha 
Published: January 2006

AbstractCurrently, the sterility of heat‐processed food and pharmaceuticals is assessed in terms of an F0 value, based on the equivalence of the heat treatment to an isothermal process at a reference temperature. This F0 value, however, has a meaning if, and only if, the inactivation kinetics of the targeted spores (or cells) follow a first‐order relationship and the temperature dependence of the D value, the reciprocal of the rate constant, is log‐linear. There is growing evidence that these conditions are not satisfied by many spores, including those of Clostridium botulinum and vegetative cells. Consequently, a replacement for the F0 value is proposed in the form of a momentary equivalent time at the reference temperature based on the actual survival pattern of the spores, which need not be log‐linear. This equivalent time can be calculated together with the theoretical survival ratio in real time, thus enabling an operator to monitor the lethality of ongoing industrial heat processes. The concept is demonstrated with published survival data of C. botulinum, for which the Weibullian and log‐logistic models served as primary and secondary models, respectively. The safety factor according to the proposed method is in the number of added minutes of processing, beyond the theoretical time needed to reduce the survival ratio of the targeted spores or cells to a level that would produce practical (or commercial) sterility. Copyright © 2006 Society of Chemical Industry
Response of growing Japanese quails to dietary concentration of L‐threonine
Authors: Mandal Asit B , Kaur Sarabmeet , Johri Anurag K , Elangovan Arumbackam V , Deo Chandra , Shrivastava Harendra P 
Published: January 2006

AbstractThe influence of dietary levels of L‐threonine (Thr) on growth and immune response was investigated in growing (0–5 weeks of age) Japanese quails (n = 288). Three dietary treatments were formulated using three levels of Thr [9.6, 10.2 and 11.2 kg−1 diet dry matter (DM)] at a fixed protein level of 233 g kg−1 and an energy level of 12.15 MJ (2900 kcal) metabolizable energy (ME) kg−1 feed dry matter. A metabolism trial with a 3‐day collection period was conducted at the third week of age employing all the birds. The cell‐mediated (using PHA‐P) and humoral (SRBC response) immune responses were measured at the fourth week of age. Carcass traits were assessed at the end of fifth week of age. Body weight gain was lower (P < 0.01) in birds received 9.6 g Thr kg−1 DM than in groups fed 10.2 g or 11.2 g kg−1 DM in the diet, but there was no significant difference in gain between the groups fed 10.2 or 11.2 g Thr kg−1 DM in the diet. Feed intake differed significantly owing to Thr levels being lowest (P < 0.05) at 9.6 g Thr kg−1 DM in the diet. Feed conversion ratio (FCR), protein efficiency and energy efficiency improved at the 11.2 g kg−1 level from 0 to 3 weeks of age; however, from 3 to 5 weeks of age, better FCR emanated from a diet with 9.6 g Thr kg−1 DM. The nitrogen balance did not differ (P > 0.05) with Thr level. Carcass traits, relative weight of immune organs and cell‐mediated (PHA‐P) and humoral (SRBC response) immune responses did not differ significantly (P > 0.05) as a result of the dietary treatments. Copyright © 2006 Society of Chemical Industry
Variation across environments in patterns of water uptake and endosperm modification in barley varieties and variety mixtures
Authors: Swanston J Stuart , Newton Adrian C , Hoad Stephen P , Spoor William 
Published: January 2006

AbstractThe malting barley varieties Chalice, Chariot, Optic and Prisma and all four three‐component mixtures derived from them were grown at three sites in eastern Scotland in 2000. Following harvest, malting samples were obtained for each trial entry from grain retained by a 2.5 mm sieve. Water uptake during the steeping phase of malting was determined on all samples at two of the sites. Of the varieties, Chariot was shown to have more extensive and also, at one site, more even hydration than the other varieties, whereas the mixtures were generally similar to the other three varieties in water uptake. Malt samples were tested for cell wall modification using a fluorescence method that assessed individual grains, so enabling both homogeneity and extent of modification to be calculated. There were significant differences between genotypes and between sites, with Chariot and Chalice showing poor modification at one site, which led to reduced levels of hot water extract. The variety Prisma had a lower level of predicted spirit yield at another site, possibly owing to over‐modification, and Optic was the only variety to give consistently high spirit yield at all three sites, despite considerable variations in levels of modification. The mixtures had better consistency in their malting results than the varieties, with the exception of Optic, and also performed well at sites where modification was sub‐optimal. Differences in spirit yield were greater between sites than between varieties, indicating that genotypic constitution may not always be a reliable predictor of phenotypic expression of malting quality. Copyright © 2006 Society of Chemical Industry
Comparative treatment of small diameter (≤400 µm) vascular lesions using extended pulse dye lasers
Authors: Goldberg David J. , Marmur Ellen S. , Amin Snehal , Hussain Mussarat 
Published: January 2006

AbstractBackground and ObjectivesExtended‐pulse dye lasers (EPDL) are commonly used to treat a variety of vascular lesions. This study evaluated whether differences in pulse formats and cooling methods might affect outcome in the treatment of small facial telangictasia.Study Design/Materials and MethodsTen subjects presenting with symmetric, bilateral facial telangiectasia were studied. Each side of the face was treated with either the V‐Star™ smart‐cool air cooling (Cynosure, Inc.) (VS) or V‐beam DCD cooling (Candela, Inc.) (VB) EPDL treatments with both systems were undertaken with a 10‐milliseconds pulse duration, 1 J/cm2 below the purpuric threshold, with up to three passes.ResultsTreatment clearance with the VS EPDL occurred with a lower fluence, using fewer passes than with the VB EPDL (P < 0.05).ConclusionsAlthough both the currently popular EPDL systems are highly effective in the treatment of small facial telangiectasia, clinical differences can be seen between these two systems. Lasers Surg. Med. 38:106–111, 2006. © 2006 Wiley‐Liss, Inc.
Photodynamic therapy of newly implanted glioma cells in the rat brain
Authors: Madsen Steen J. , Angell‐Petersen Even , Spetalen Signe , Carper Stephen W. , Ziegler Sarah A. , Hirschberg Henry 
Published: January 2006

AbstractBackground and ObjectiveA syngeneic rat brain tumor model is used to investigate the effects of aminolevulinic acid (ALA)‐mediated photodynamic therapy (PDT) on small clusters of tumor cells sequestered in normal brain.Study Design/Materials and MethodsBiodistribution studies on tumor‐bearing animals were undertaken in order to determine the occurrence of photosensitizer in tumor cells invading normal brain. ALA–PDT toxicity in normal brain and gross tumor were evaluated from histopathology. Effects of PDT on isolated glioma cells in normal brain were investigated by treating animals 48 hours after tumor cell implantation.ResultsFluorescence microscopy of frozen tissue sections showed that photosensitizer content was limited and variable in tumor tissue invading normal brain. ALA–PDT with high light doses resulted in significant damage to both gross tumor and normal brain, however, the treatment failed to prolong survival of animals with newly implanted glioma cells. In contrast, animals inoculated with tumor cells pre‐incubated in vitro with ALA showed a significant survival advantage in response to PDT.ConclusionThe results show that ALA–PDT could not prevent tumors from forming if treatment was performed shortly after tumor initiation. This was likely due to inadequate levels of ALA/PpIX in the glioma cells. Lasers Surg. Med. © 2005 Wiley‐Liss, Inc.
Do pulsed lasers produce an effective photodynamic therapy response?
Authors: Strasswimmer John , Grande Donald J. 
Published: January 2006

AbstractBackgroundPhotodynamic therapy (PDT) in dermatology is traditionally performed with topical aminolevulinic acid (ALA) and continuous‐wave (CW) illumination with blue or red light. Recently, several authors have reported success with laser and other pulsed‐light sources for PDT. While the clinical benefits on sun‐exposed skin are apparent, no study has demonstrated that the pulsed light sources are responsible for the observed response.Study DesignA placebo‐controlled study of two pulsed light sources previously reported for PDT: the pulsed dye laser (PDL) or broadband flashlamp filtered intense pulsed light (IPL). Sun‐hidden skin was prepared with microdermabrasion and acetone scrub followed by ALA under occlusion. Laser or IPL was delivered under conditions previously reported to produce a clinical response. Control areas were exposed to standardized CW blue light or to no light. A second control area was prepared and received light and the ALA vehicle.ResultsIPL and PDL demonstrated a faint dose‐response effect on PDT activation, but were less potent than a smaller fluence of CW blue light. Ambient light activated ALA‐treated skin.ConclusionBoth IPL and PDL are capable of activation of PDT but produce dramatically less PDT reaction than the standard CW blue‐light broadband source. Physicians desiring a robust PDT response might select CW sources over pulsed sources. Ambient light may activate a PDT reaction. Lasers Surg. Med. © 2005 Wiley‐Liss, Inc.
Methylene blue‐mediated photodynamic therapy: A possible alternative treatment for oral lichen planus
Authors: Aghahosseini Farzane , Arbabi‐Kalati Fateme , Fashtami Leila Ataie , Djavid Gholamreza Esmaeeli , Fateh Mohsen , Beitollahi Jalil Momen 
Published: January 2006

AbstractBACKGROUND AND OBJECTIVESIn this study, methylene blue‐mediated photodynamic therapy (MB‐PDT) was used as a possible alternative method for the treatment of oral lichen planus (OLP).STUDY DESIGN/MATERIALS AND METHODSThirteen patients with 26 OLP lesions were enrolled in this study. Patients were instructed to gargle a 5% methylene blue solution in water for 5 minutes. Ten minutes later, irradiation was performed by laser light (λ = 632 nm, light exposure dose = 120 J/cm2). Lesions were evaluated pre and post‐operatively and at follow‐up sessions by changes in sign and symptom (pain) scores, and size of lesions.RESULTSImprovement in sign scores was achieved in 16 lesions. Four keratotic lesions disappeared completely. There was a statistically significant decrease in sign and symptom scores 1 week after treatment and at follow‐up sessions up to 12 weeks. Average reduction in size of lesions was 44.3%.CONCLUSIONMB‐PDT seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB‐PDT in control of OLP for a longer period of time. Lasers Surg. Med. © 2005 Wiley‐Liss, Inc.
Structural characterization of silica modified polyimide membranes
Authors: Boroglu Mehtap Safak , Boz Ismail , Gurkaynak Mehmet Ali 
Published: January 2006

AbstractPolyimide and hybrid polyimide‐siloxane were synthesized by polycondensation, imidization, and sol‐gel reaction. The polyimides were prepared from pyromellitic dianhydride (PMDA) and 4,4‐oxydianiline (ODA) in N‐methyl‐2‐pyrollidone (NMP). Trimethoxyvinyl silane (TMVS) was used as a source of silica. Their surface morphologies, structures and thermal performances were determined using scanning electron microscopy (SEM), infrared spectroscopy (IR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that the silica particles were finely and rather homogeneously dispersed in polymers. The glass transition temperature (Tg) of hybrid membrane materials increased with the increasing silica content. TGA analysis showed that polyimides were thermally stable with silica. Modified polyimide‐siloxane films, thermal characteristics were found to be better than the polyimide films without silica. Copyright © 2006 John Wiley & Sons, Ltd.
Erythrocyte concentrations of metabolites or cumulative doses of 6‐mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia
Authors: Halonen Päivi , Mattila Jorma , Mäkipernaa Anne , Ruuska Tarja , Schmiegelow Kjeld 
Published: January 2006

AbstractBackgroundDuring therapy consisting of 6MP and MTX, metabolites accumulate in the erythrocytes. The erythrocyte levels of metabolites reflect the intensity of therapy. Whether they are associated with hepatotoxicity manifested as histological liver changes is not known. We studied the association of the metabolites and cumulative doses of 6MP and MTX with histological liver disease.MethodsSerial measurements of E‐TGN, E‐MTX, and ALT during maintenance therapy were performed and cumulative doses of 6MP and MTX were calculated as g/m2 in 16 children with ALL. Each subject underwent a percutaneous liver biopsy at the end of therapy to screen for histological liver disease.ResultsNo differences in E‐TGN, E‐MTX, or cumulative doses of 6MP or MTX were detected in the children with ALL with liver fibrosis compared to those without fibrosis, or in the children with less liver fatty change compared to those with more fatty change. Serum median ALT levels correlated significantly positively with cumulative doses of 6MP during therapy (rS = 0.527, P = 0.036), but not with cumulative doses of MTX, or E‐TGN, or E‐MTX.ConclusionsErythrocyte levels of the metabolites or the cumulative doses of 6MP and MTX do not predict histological liver disease in children treated for ALL. © 2006 Wiley‐Liss, Inc.
Prevention and monitoring of invasive fungal infections in pediatric patients with cancer and hematologic disorders
Authors: Hovi Liisa , Saxen Harri , Saarinen‐Pihkala Ulla M. , Vettenranta Kim , Meri Taru , Richardson Malcolm 
Published: January 2006

AbstractBackgroundThe occurrence of invasive fungal infection (IFIs) in a pediatric hematology/oncology unit after renovation of the ventilation system, and initiating routine azole antifungal prophylaxis was monitored. In addition, the value of serial screening for Aspergillus galactomannan (GM) for diagnosing invasive aspergillosis was assessed.ProcedureA total of 98 consecutive high‐risk pediatric patients were prospectively surveyed for signs of IFI and weekly monitored for serum GM. The data was not made available to treating physicians.ResultsOnly 2 patients had proven and 27 possible IFI based on the European Organization for Research and Treatment of Cancer/Mycoses Study Group definitions. The incidence of proven IFI was 1/31 (3.2%) in the allogeneic stem cell transplant (SCT) (Aspergillus spp), 0/26 in the autologous SCT, and 1/60 (1.6%) in the induction therapy group (C. krusei). GM was detected at least in one tested sample in 12/98 patients (12.2%), in five patients in two or more sequential samples. In the latter group, IFI was proven in one patient and could not be excluded in the others. Four of the five patients belonged to the 31 allogeneic and one to the 26 autologous SCT patients. In patients with only one positive GM test none developed signs of IFI and only one received empirical amphotericin B.ConclusionsWith the currently used preventative and prophylactic measures, IFI is uncommon in children with high‐risk for infection. Regular screening for GM could be useful among allogeneic SCT patients and two positive samples should prompt further investigative procedures and pre‐emptive antifungal therapy. Pediatr Blood Cancer 2007;48:28–34. © 2006 Wiley‐Liss, Inc.
Immunotherapy for severe aplastic anemia following orthotopic liver transplantation in children
Authors: Sanchez Rosa , Rosenthal Philip , Goldsby Robert 
Published: January 2006

AbstractSevere aplastic anemia is a well‐recognized complication of fulminant non‐A, non‐B, and non‐C hepatitis requiring orthotopic liver transplantation. The first line of therapy for cure in the treatment of aplastic anemia is a histocompatible bone marrow transplant. Immunosuppressive therapy is also effective if a histocompatible donor is not available. We describe two children who developed severe aplastic anemia following orthotopic liver transplant who achieved bone marrow recovery with a single course of anti‐thymocyte globulin, solumedrol, and adjustments to their immunosuppressive therapy for prevention of liver allograft rejection. Pediatr Blood Cancer 2007;49:93–98. © 2006 Wiley‐Liss, Inc.
Progressive vacuolar myelopathy and leukoencephalopathy in childhood acute lymphoblastic leukemia and transient improvement with vitamin B12
Authors: Olcay Lale , Irkkan Çiğdem , Şenbil Nesrin , Uzun Hacı , Basmacı Mehmet , Gürer Y.K. Yavuz 
Published: January 2006

AbstractVacuolar myelopathy (VM) in leukemia is rare. We report a boy with leukemia who developed isolated central nervous system (CNS) relapse during reinduction therapy. 5 months after cranial radiotherapy, he gradually developed quadriparesis. Magnetic resonance imaging revealed an intramedullary lesion which extended through the cervical spine. Serum vitamin B12, folic acid, cerebrospinal fluid methyl malonic acid were normal. Viral screening by ELISA was negative. He had lymphopenia, and reduced immunoglobulins, from a cardiac arrest. Biopsy revealed VM. He responded to weekly vitamin B12 treatment but on the 6th week of the therapy he died after developing periventricular, gliotic, hyperintense lesions in the brain. Pediatr Blood Cancer 2007;49:754–758. © 2006 Wiley‐Liss, Inc.