bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrovascular reactivity impairment in genetic frontotemporal dementia
Authors: Kancheva Ivana , Bouzigues Arabella , Russell Lucy L. , Foster Phoebe H. , Ferry-Bolder Eve , van Swieten John , Jiskoot Lize , Seelaar Harro , Sanchez-Valle Raquel , Laforce Robert , Graff Caroline , Galimberti Daniela , Vandenberghe Rik , de Mendonça Alexandre , Tiraboschi Pietro , Santana Isabel , Gerhard Alexander , Levin Johannes , Sorbi Sandro , Otto Markus , Pasquier Florence , Ducharme Simon , Butler Chris R. , Ber Isabelle Le , Finger Elizabeth , Tartaglia Maria Carmela , Masellis Mario , Synofzik Matthis , Moreno Fermin , Borroni Barbara , Rohrer Jonathan D. , van der Weerd Louise , Rowe James B. , Tsvetanov Kamen A. 
Published: March 2024

AbstractINTRODUCTIONCerebrovascular reactivity (CVR) is an indicator of cerebrovascular health and its signature in hereditary frontotemporal dementia (FTD) remains unknown. We investigated CVR in genetic FTD and its relationship to cognition.METHODSCVR differences were assessed between 284 pre-symptomatic and 124 symptomatic mutation carriers, and 265 non-carriers, using resting-state fluctuation amplitudes (RSFA) on component-based and voxel-level RSFA maps. Associations and interactions between RSFA, age, genetic status, and cognition were examined using generalised linear models.RESULTSCompared to non-carriers, mutation carriers exhibited greater RSFA reductions, predominantly in frontal cortex. These reductions increased with age. The RSFA in these regions correlated with cognitive function in symptomatic and, to a lesser extent, pre- symptomatic individuals, independent of disease stage.DISCUSSIONCVR impairment in genetic FTD predominantly affects frontal cortical areas, and its preservation may yield cognitive benefits for at-risk individuals. Cerebrovascular health may be a potential target for biomarker identification and disease-modifying efforts.
Identification and characterization of thede novomethyltransferases for eukaryotic N6-methyladenine (6mA)
Authors: Cheng Ting , Zhang Jiachen , Li Haicheng , Diao Jinghan , Zhang Wenxin , Niu Junhua , Kataoka Kensuke , Gao Shan 
Published: March 2024

ABSTRACTDNA N6-adenine methylation (6mA) is rediscovered as an important epigenetic mark in eukaryotes. We previously identified the MT-A70 family member AMT1 as the maintenance methyltransferase (MTase), but the identity of thede novoMTase(s) for 6mA establishment remains unidentified. The unicellular model eukaryoteTetrahymena thermophilaoffers a unique opportunity for studyingde novomethylation: during sexual reproduction, the 6mA-free zygotic nucleus develops into 6mA-positive new macronucleus (MAC) marked by genome-widede novomethylation. Here we identified that TET1 and TET2 are essential forde novo6mA in the new MAC, but not for maintenance 6mA in the somatic MAC. Knockout ofTET1and/orTET2not only abolished methylation on most methylatable ApT positions, but also attenuated methylation on the rest. The substantial 6mA decrease in turn altered gene expression pattern and reduced the survival rate of sexual progenies, highlighting the importance of dedicatedde novoMTase activity.
Infection of human organoids supports an intestinal niche forChlamydia trachomatis
Authors: Hovhannisyan Pargev , Stelzner Kathrin , Keicher Markus , Paprotka Kerstin , Neyazi Mastura , Pauzuolis Mindaugas , Ali Waled Mohammed , Rajeeve Karthika , Bartfeld Sina , Rudel Thomas 
Published: March 2024

AbstractSeveral reports suggest that intestinal tissue may be a natural niche forChlamydia trachomatisinfection and a reservoir for persistent infections in the human body. Due to the human specificity of the pathogen and the lack of suitable host models, there is limited knowledge on this topic. In our study, we modelled the course of the chlamydial infection in human primary gastrointestinal (GI) epithelial cells originating from patient-derived organoids. We show that GI cells are resistant to apical infection andC. trachomatisneeds access to the basolateral membrane to establish an infection. Transmission electron microscopy analysis reveals the presence of both normal as well as aberrant chlamydial developmental forms in the infected cells, suggesting a possible cell-type specific nature of the infection. Furthermore, we show that the plasmid-encoded Pgp3 is an important virulence factor for the infection of human GI cells. This is the first report ofC. trachomatisinfection in human primary intestinal epithelial cells supporting a possible niche for chlamydial infection in the human intestinal tissue.Author summaryChlamydial infection has a high global prevalence and is a major health concern. Untreated infections may cause complications and lead to serious health problems, especially in women. Although the infection is usually localized to the genital tract, experiments performed in a mouse infection model as well as the accumulating clinical data suggest that the human gastrointestinal (GI) tract might represent a hidden infection niche and a source of reinfections. In our study, we used the advantages of the organoid technology to model the chlamydial infection in patient-derived primary GI epithelial cells. We were able to show that these cells are resistant to the infection, however,Chlamydiacould utilize a basolateral entry route for efficient infection.Chlamydiaform either normal or persistent-like developmental forms in these GI epithelial cells. We also showed the importance of the plasmid-mediated virulence in the infection of human GI cells. The results obtained in the GI infection model replicated phenotypes predicted and expected forChlamydiahuman intestinal infection, and therefore support a role of the human GI tract as a potential niche for chlamydial infection.
Electroweak phase transition in singlet extensions of the standard model with dimension-six operators
Authors: Oikonomou V. K. , Giovanakis Apostolos 
Published: March 2024

The significance of the electroweak phase transition is undeniable, and although initially it was believed that it was second order, it is now believed that it is a first-order transition. However, it is not a strong first-order phase transition in the context of the standard model, and the remedy to this issue is to use the Higgs portal and directly couple the Higgs to a hidden scalar sector. This can result in a strong electroweak phase transition, while the couplings to a hidden scalar are constrained by several phenomenological constraints, such as the sphaleron rate criterion and the branching ratio of the Higgs to invisible channels. In this work, we consider the standard singlet extensions of the standard model, including dimension-six non-renormalizable operators that couple a real singlet scalar field with the Higgs doublet. As a result, we examine the effects of those Higgs-singlet couplings on the electroweak phase transition. The effective theory, where the nonrenormalizable couplings originate from, is considered to be active beyond 15 TeV. As we show, the Universe experiences a two-step electroweak phase transition, a primary phase transition in the singlet sector at a high temperature, and then a subsequent first-order phase transition from the singlet vacuum to the electroweak vacuum. The singlet’s phase transition can either be second order or first order, depending on the singlet mass and its couplings to the Higgs. In particular, we show that the dimension-six operator assists in generating a strong electroweak phase transition in regions of the parameter space that were excluded in the previous singlet extensions of the standard model. This is further apparent for low singlet masses mS<mH/2, which are rarely taken into account in the literature due to the invisible branching ratio of the Higgs boson. In some limited cases in the parameter space, the electroweak phase transition is weakened by the presence of the higher order operator.

Published by the American Physical Society
2024
Interaction mechanisms of interface management risks in complex systems of high-speed rail construction projects: an association rule mining-based modeling framework
Authors: Han Yuanwen , Shen Jiang , Zhu Xuwei , An Bang , Bao Xueying 
Published: March 2024

PurposeThis study aims to develop an interface management risk interaction modeling and analysis methodology applicable to complex systems in high-speed rail construction projects, reveal the interaction mechanism of interface management risk and provide theoretical support for project managers to develop appropriate interface management risk response strategies.Design/methodology/approachThis paper introduces the association rule mining technique to improve the complex network modeling method. Taking China as an example, based on the stakeholder perspective, the risk factors and significant accident types of interface management of high-speed rail construction projects are systematically identified, and a database is established. Then, the Apriori algorithm is used to mine and analyze the strong association rules among the factors in the database, construct the complex network, and analyze its topological characteristics to reveal the interaction mechanism of the interface management risk of high-speed rail construction projects.FindingsThe results show that the network is both scale-free and small-world, implying that construction accidents are not random events but rather the result of strong interactions between numerous interface management risks. Contractors, technical interfaces, mechanical equipment, and environmental factors are the primary direct causal factors of accidents, while owners and designers are essential indirect causal factors. The global importance of stakeholders such as owners, designers, and supervisors rises significantly after considering the indirect correlations between factors. This theoretically explains the need to consider the interactions between interface management risks.Originality/valueThe interaction mechanism between interface management risks is unclear, which is an essential factor influencing the decision of risk response measures. This study proposes a new methodology for analyzing interface management risk response strategies that incorporate quantitative analysis methods and considers the interaction of interface management risks.
Why women on corporate boards are more than just tokens: an Indian perspective
Authors: Bhardwaj Sneh , Morgan Damian , Elms Natalie 
Published: March 2024

Purpose
Situated in the context of India, where women’s representation on corporate boards remains low, this study aims to explore whether and how tokenism impacts the behaviours of female directors.

Design/methodology/approach
The boardroom experiences and perceptions of 14 women directors are explored through semi-structured interviews and analysed using an inductive and interpretive process. Also, to get a counter perspective and avoid the social desirability bias from the women participants’ responses, 16 men directors are interviewed.

Findings
The study finds that, as gender minorities, women directors' visibility on boards can create performance pressures on these women. To counter gender-based prejudices, women directors consciously alter their behaviours and project both male and female traits consistent with the director role. By doing so, women directors overcome tokenistic stereotypes and are accepted as part of the director in-group, irrespective of their numeric representation on the board.

Practical implications
The research has implications for governments attempting to increase women’s board presence through affirmative actions and for firms aiming to improve the gender diversity of their board composition.

Originality/value
These findings present an alternative perspective on women directors’ board behaviour by exploring the applicability of Western trends on tokenism and critical mass in the context of India, adding to the vast body of literature concerned with minorities on corporate boards.
Certification bodies’ interpretation and application of the ISO 19011 audit process guidelines
Authors: Sepeng Thembekile Debora , Lourens Ann , Van der Merwe Karl , Gerber Robert 
Published: March 2024

PurposeThe purpose of this paper is to show that third-party quality audits (TPQAs) facilitate performance improvement and give confidence to organisations concerning the process quality of services and products. However, because of inconsistencies and unethical practices often observed in the industry, organisations question the significance of TPQA. A perception exists that its initial purpose as an impartial tool ensuring quality of deliverables is no longer upheld. Hence, the need to determine and explain the influence of the ISO 19011 standard interpretation on the application of the audit guidelines in performing TPQA, to promote consistency in the audit process.Design/methodology/approachThe study employed document analysis of the ISO 19011 standard, followed by semi-structured interviews with certification managers (CBs) to gain insight related to their interpretation and application of the ISO 19011 guidelines.FindingsThe CBs interpret the ISO 19011 guidelines differently; hence, their application of the standard to compile their audit documents differ. Adherence to the principles of auditing particularly, integrity and independence were found as the core of the audit process while their disregard reflects failure of the real intent of auditing. The inconsistencies in the audit procedures and documents developed for auditors are ascribed to some CBs’ personal interpretations.Originality/valueThe study explores how the different interpretations of the ISO 19011 standard prevail and are perceived by the CBs and auditors. The findings aim to support standardisation and reduce the variations across and amongst the different CBs and auditors.
Mindfulness and creative process engagement: the mediating role of workplace relational systems
Authors: Awan Usama , Sufyan Muhammad , Ameer Irfan , Shamim Saqib , Akhtar Pervaiz , Zia Najam Ul 
Published: March 2024

PurposeDespite widespread recognition of the importance of mindfulness in organizational science literature, little is known about how mindfulness motivates individuals to configure information processing and team member exchange relationships to increase creative process engagement. Drawing on motivated information processing theory, this study conceptualizes and empirically examines whether and how mindfulness motivates individuals toward creative process engagement.Design/methodology/approachThe authors collected data through an online survey from 311 respondents working in the Research and Development (R&D) departments of organizations in multiple industries in Pakistan. For analytical purposes, the authors have applied the structural equation modeling technique.FindingsThis study advances a different view of individual mindfulness on the creative process engagement in the following ways. First, mindfulness enables individuals to self-regulate in specific situations and become effective in fostering creative process engagement. Second, this study extends research on relational information processing by linking it to mindfulness and creative process engagement. Relational information processing partially mediates the relationship between mindfulness and creative process engagement. Third, this study highlights that mindfulness motivates individuals to focus more on developing quality working relationships, but they seem less willing to participate in idea generation and problem-solving solutions.Originality/valueThe study findings provide implications for research on mindfulness, creativity and motivated information processing to enhance individuals’ creative process engagements. The authors also discuss the implications for executives on the relational and creative benefits of mindfulness.
From text to video with AI: the rise and potential of Sora in education and libraries
Authors: Adetayo Adebowale Jeremy , Enamudu Augustine I. , Lawal Folashade Munirat , Odunewu Abiodun Olusegun 
Published: March 2024

Purpose
This study investigates the transformative role of Sora in education and libraries. This study aims to explore Sora’s capabilities and potential implications for enhancing learning experiences and enriching library resources.

Design/methodology/approach
Using an exploratory approach, this paper analyzes Sora’s functionalities, focusing on its ability to convert textual descriptions into dynamic video content swiftly and accurately. It examines the ways in which Sora can augment learning through interactivity, personalization and accessibility, as well as its capacity to digitize cultural heritage and promote literacy in library settings.

Findings
Sora emerges as a potential powerful tool for education and libraries, offering opportunities for diverse learning modalities, creativity and critical thinking. Its capacity to facilitate immersive storytelling and educational gamification holds promise for engaging users and fostering community involvement. However, ethical considerations such as bias mitigation and equitable access must be addressed to maximize Sora’s benefits.

Originality/value
This study contributes to the understanding of artificial intelligence’s potential in education and libraries, particularly through the lens of Sora.
Manager myopia and green technology innovation
Authors: Jian Jianhui , Tian Haiyan , Hu Dan , Tang Zimeng 
Published: March 2024

PurposeWith the growing concern of various sectors of society regarding environmental issues and the promotion of sustainable development, green technology innovation is generally considered to be conducive to the long-term development of enterprises. However, because of the existence of agency problems, managers may have shortsighted behaviors. Then how will managers' shortsighted behaviors affect enterprises' green technology innovation?Design/methodology/approachThis paper uses machine learning-based text analysis methods to construct a manager myopia index based on the data from A-share listed companies on the Shanghai and Shenzhen Stock Exchanges from 2015 to 2020. We examine the impact of manager myopia on green technology innovation in companies.FindingsOur study finds that manager myopia significantly inhibits green technology innovation in companies. However, when multiple large shareholders coexist and the proportion of institutional investors' holdings is high, it can alleviate the inhibitory effect of manager myopia on green innovation. Heterogeneity tests show that the impact of manager myopia on green technology innovation is relatively significant in non-state-owned and manufacturing companies, as well as in the electricity industry. Robustness tests demonstrate that our conclusions remain valid after using propensity score matching to eliminate endogeneity problems.Originality/valueFrom the perspective of corporate governance, this paper incorporates managers' shortsightedness, multiple large shareholders and institutional investors' shareholding ratios into the same logical framework, analyzes their internal mechanisms, helps improve corporate governance, enhances green innovation capabilities and has strong implications for the implementation of national innovation-driven development strategies and the achievement of “carbon peak” and “carbon neutrality” targets.
Understanding the link: the competencies and motivations of nascent entrepreneurs to engage in sustainable entrepreneurship
Authors: Rojas-Cruz Lilia Raquel , Husted Byan 
Published: March 2024

Purpose
This study aims to understand the relationship between entrepreneurial competencies (self-efficacy and social capital) and sustainable entrepreneurship and its incidence through entrepreneurial motivations (opportunity and necessity entrepreneurship).

Design/methodology/approach
The authors adopt a quantitative approach and use ordinary least squares regressions and bootstrapping analysis to test the hypotheses about the relationship between entrepreneurial competencies and sustainable entrepreneurship mediated by entrepreneurial motivations using a cross-sectional sample of 2,356 nascent entrepreneurs from the Global Entrepreneurship Monitor 2021–2022 report.

Findings
Evidence suggests that sustainable entrepreneurship is positively influenced by both opportunity- and necessity-driven entrepreneurship. Additionally, the results show that both entrepreneurial motivations positively mediate the relationship between self-efficacy and sustainable entrepreneurship.

Originality/value
The approach departs from the traditional unidimensional perspective on entrepreneurial motivations, recognizing that an entrepreneur can simultaneously embody varying degrees of both motivations. By integrating the study of entrepreneurial competencies and motivations into sustainable entrepreneurship, we can gain a holistic understanding of the dynamics at play.
Exploring the potential of smartphone MEMS sensors for cost-effective rotating machinery speed estimation
Authors: Goel Anuj Kumar , Naikan V.N.A. 
Published: March 2024

Purpose
The purpose of this study is to explore the use of smartphone-embedded microelectro-mechanical sensors (MEMS) for accurately estimating rotating machinery speed, crucial for various condition monitoring tasks. Rotating machinery (RM) serves a crucial role in diverse applications, necessitating accurate speed estimation essential for condition monitoring (CM) tasks such as vibration analysis, efficiency evaluation and predictive assessment.

Design/methodology/approach
This research explores the utilization of MEMS embedded in smartphones to economically estimate RM speed. A series of experiments were conducted across three test setups, comparing smartphone-based speed estimation to traditional methods. Rigorous testing spanned various dimensions, including scenarios of limited data availability, diverse speed applications and different smartphone placements on RM surfaces.

Findings
The methodology demonstrated exceptional performance across low and high-speed contexts. Smartphones-MEMS accurately estimated speed regardless of their placement on surfaces like metal and fiber, presenting promising outcomes with a mere 6 RPM maximum error. Statistical analysis, using a two-sample t-test, compared smartphone-derived speed outcomes with those from a tachometer and high-quality (HQ) data acquisition system.

Research limitations/implications
The research limitations include the need for further investigation into smartphone sensor calibration and accuracy in extremely high-speed scenarios. Future research could focus on refining these aspects.

Social implications
The societal impact is substantial, offering cost-effective CM across various industries and encouraging further exploration of MEMS-based vibration monitoring.

Originality/value
This research showcases an innovative approach using smartphone-embedded MEMS for RM speed estimation. The study’s multidimensional testing highlights its originality in addressing scenarios with limited data and varied speed applications.