bluuebunny/crossref_metadata_2025_split huggingface dataset:
Janus film for passive radiative cooling and solar heating for year-round thermal regulation
Authors: Li Bingyao 
Published: March 2024

Abstract
The energy demand for heating and cooling buildings constitutes approximately 30% of the global energy consumption, underscoring the imperative for sustainable temperature regulation solutions. This research introduces an approach for building thermal management, employing a Janus film that integrates advanced photonic metamaterials with spectrally selective solar absorber and radiative cooler. This configuration enables a dynamic adjustment of solar absorption properties, crucial for adapting to seasonal and climatic variations. During winter, the aluminum nanoparticles embedded within polyethylene film show high solar absorptance and low thermal emittance that facilitates solar heating during the daytime while preserving heat during the nighttime. Concurrently, in the summer scenario, the PDMS thin film atop of aluminum thin layer demonstrates high solar reflectance and high thermal emittance, activating the radiative cooling capability and dissipating heat through the atmospheric transparent window. Simulation results confirm the film’s efficacy, indicating a potential for a 8.2°C reduction in ambient temperature during peak summer conditions and maintaining a near-ambient temperature during winter daylight hours which is 7.2°C above the regular black absorber. Energy-saving simulation shows that is projected to decrease energy saving 57 GJ per year for San Francisco. This dual-functional technology heralds a significant advancement in passive thermal regulation, offering a versatile and energy-efficient solution for buildings, vehicles, and agricultural greenhouses across diverse geographical locations.
Dynamic mesophase transition induces anomalous suppressed and anisotropic phonon transport revealed by unified machine learning potential
Authors: 张 一 , Yu Linfeng , 董 可鑫 , 杨 麒 
Published: March 2024

Abstract
The physical/chemical properties undergo significant transformation in the different states arising from phase transition. However, owing to the lack of a dynamic perspective, transitional mesophases are largely underexamined, which is limited by the high resources burden of first-principles. Here, using molecular dynamics (MD) simulations empowered by advanced unified machine learning (ML) potential, we proffer an innovative paradigm for phase transition: regulating the thermal transport properties via the transitional mesophase triggered by a uniaxial force field. We investigate the mechanical, electrical, and thermal transport properties of the novel two-dimensional carbon allotrope of Janus-graphene with strain engineered phase transition. Notably, we found that the transitional mesophase significantly suppresses the thermal conductivity and induces strong anisotropy near the phase transition point. ML-driven MD simulations meticulously recapitulate the atomic-scale dynamic metamorphosis exhibited in Janus-graphene, where thermal vibration-induced intermediate amorphous or interfacial phases induce strong and anisotropic interfacial thermal resistance, which eludes capture from traditional first-principles methods. The investigation not only endows us with a novel perspective on mesophases during phase transitions but also augment our holistic comprehension of the evolution of material properties.
Distribution of FEN1 mediated by TM9SF1: unraveling the potential mechanisms of DNA damage
Authors: Zhou Fengqiao , Zhang Lu , Chen Huabo , Xiong Jinsong , Yang Zean , Gong Baoxian , Zhao Zhenwang , Xiong Wei , Zhang Mengxin , Gao Yihong , Cao Fengsheng , Huang Min , Liu Yang , Qiu Guangyu , Xiao Juan 
Published: March 2024

Abstract
Transmembrane 9 superfamily protein member 1 (TM9SF1) has abnormal overexpression in specific clinical diseases; however, its precise role in disease progression remains poorly understood. The current study revealed the critical importance of maintaining appropriate TM9SF1 levels for the proper distribution of FEN1, a protein crucial for DNA repair. TM9SF1 interacted with FEN1 through its N-terminal region spanning amino acids 1-236, which could translocate into the nucleus, while the C-terminal segment spanning amino acids 237–606 was responsible for the cellular localization of TM9SF1. Overexpression of TM9SF1 led to the sequestration of FEN1 in the cytoplasm, thus hindering FEN1’s entry into the nucleus. Consequently, DNA repair capacity was compromised, leading to increased DNA damage and subsequently cell growth inhibition. Moreover, TM9SF1 knockdown in 293T cells or its knockout in mouse kidney cells did not affect the expression levels and distribution of FEN1 or DNA damage induction. The current study revealed the mechanism of the abnormally high TM9SF1 expression in the occurrence and development of clinical diseases, thus positioning TM9SF1 as a potential drug target.
Structural Complexity of the Bone Trabecular in Children Exposed to Different Sunlight Conditions: A Cross-Sectional Study with Panoramic Radiographs
Authors: Losso André Ramos , de Oliveira Carla Barros , Fonseca-Gonçalves Andréa , Visconti Maria Augusta 
Published: March 2024

Abstract

Objectives: This study aimed to assess the trabecular bone structural complexity in children with varying sunlight exposure using panoramic radiographs (PR) and investigate potential implications for bone metabolism. Fractal dimension (FD) and pixel intensity (PI) were employed for comparison.
Materials and Methods: Panoramic radiographs (n=120) of 6 to 9-year-old children, divided into more (n=60) and less (n=60) sunlight exposure groups, were assessed. ImageJ® software was used to analyze three regions of interest (ROI) in each radiograph. FD, determined by the box-counting method, and PI values were compared across ROIs and between exposure groups and genders using Kruskal-Wallis and t-tests (p<0.05).
Results: Children with less sunlight exposure exhibited higher FD values (3.60 ± 0.29) compared to those with more exposure (3.31 ± 0.29) (p=0.000), particularly in ROI2 and ROI3. No gender-based differences were observed (p=0.607). PI values were similar between exposure groups (p=0.735) and genders (p=0.553), except for a significant difference in ROI2 of less exposed children (62.76 ± 20.48) compared to more exposed ones (78.30 ± 65.20).
Conclusion: Reduced sunlight exposure in children was associated with higher FD values, impacting trabecular bone structural complexity. However, total PI values remained unaffected by sunlight exposure. This suggests that dentists, utilizing FD and PI analysis on routinely requested PR, can contribute to the early detection of potential bone variations in children.
Clinical Relevance: Understanding FD and PI applications in PR can empower dentists for the early identification of bone variations in pediatric patients during routine clinical assessments.
Monte-Carlo Simulation Based Value-at-Risk for Non-Gaussian Seasonal Stochastic Volatility Model
Authors: SUN Yongbo , JIANG Zhengjun 
Published: March 2024

Abstract

Commodity option has relatively low correlations with equities and bonds and is a good diversification asset to a portfolio compared with traditional assets. However, commodity has seasonal patterns compared with other assets. In this article, we combine stochastic volatility model with seasonal patterns and do risk measurement such as calculating options' value-at-risk (VaR). We also study non-Gaussian stochastic volatility model in student \(t\) distribution and skew-student-$t$ distribution instead of usual Gaussian distribution which take skewness and fat tails into consideration with tail losses and extreme events typical of commodity markets. Our results demonstrate that non-Gaussian distributed seasonal stochastic volatility model can better estimate VaR and has higher probability that extreme cases may happen. This research suggests that our model can serve as a powerful tool for investors seeking to manage risks more effectively in volatile commodity markets, highlighting the importance of considering both seasonal influences and distributional characteristics in financial modeling.
Cross-Hedge Efficiency in the Iberian Gas Market: Evaluating the Role of TTF and NBP in Mitigating Price Volatility
Authors: Leite Ana Catarina de Paula , Pimentel Liliana Marques , Monteiro Leandro 
Published: March 2024

Abstract
This study evaluates the hedging effectiveness of TTF and NBP against price volatilities in the Iberian Peninsula's natural gas market (PVB). The methodology includes a comparative analysis of five hedging strategies, including the simple minimum variance approach and the more sophisticated BEKK model, which belongs to the GARCH family. The analysis shows that TTF and NBP serve as efficient hedging instruments, demonstrating in particular their effectiveness as cross-hedging tools in liquidity-constrained markets such as MIBGAS (Iberian Gas Market). In particular, the study finds that simpler models can provide hedge effectiveness comparable to that of more complex models. From a practical point of view, the results advocate that market participants use a mix of hedging strategies and dynamic approaches to manage market volatility. In addition, the study underscores the critical role of regulatory frameworks in fostering market integration and improving liquidity, providing valuable insights for market participants navigating the complexities of natural gas markets.
Sources of microplastics to two Southeast Michigan rivers and biofilm responses plastic substrata
Authors: Troost Jennifer L. , Baker Sadie M. , Chaudry Morgan H. , Judd Kristin E. 
Published: March 2024

Abstract

Plastic pollution is an emergent global issue in freshwater and marine ecosystems. Microplastics can be introduced into waterways from a variety of sources, although the relative importance of a source for a given watershed is not well understood. To determine whether medium-sized wastewater treatment plants are significant sources of microplastics to rivers that feed into Lake Erie, we measured microplastic load up and downstream of two southeast Michigan wastewater treatment plants. We also performed experiments to test the effects of plastic on stream biofilm function. We detected a significant increase in the microplastic load downstream from the Ypsilanti wastewater treatment plant, which empties into the Lower Rouge River but not the Ann Arbor wastewater treatment plant, which empties into the Huron River. However, the background microplastic load was 10x higher in the Huron River compared to the Lower Rouge River, likely obscuring our ability to detect microplastic wastewater inputs. We found a positive relationship between river discharge and microplastic load at the Huron River site, which drains a larger watershed area than the Lower Rouge site, suggesting that watershed sources may be more important than wastewater treatment plant inputs over larger spatial scales. In biofilm experiments, biofilms grown on high-density polyethylene and polypropylene had significantly lower metabolic diversity and metabolic response, respectively. Overall, our findings indicate that attention should be directed to both point and nonpoint sources to reduce microplastic pollution and that plastics may negatively affect the function of stream biofilm communities.
Genome-Wide Association Study and Meta-Analysis of Phytosterols Identifies a Novel Locus for Serum Levels of Campesterol
Authors: Alenbawi Jamil , Al-Sarraj Yasser A. , Umlai Umm-Kulthum I. , Kadhi Ayat , Hendi Nagham N. , Nemer Georges , Albagha Omar M. E. 
Published: March 2024

Abstract

Sitosterolemia is a rare inherited disorder caused by mutations in the ABCG5/ABCG8 genes. These genes encode proteins involved in the transport of plant sterols. Mutations in these genes lead to decreased excretion of phytosterols, which can accumulate in the body and lead to a variety of health problems, including premature coronary artery disease. We conducted the first genome-wide association study (GWAS) in the Middle East/North Africa (MENA) population to identify genetic determinants of plant sterol levels in Qatari people. GWAS was performed on serum levels of β-sitosterol and campesterol using the Metabolon platform from Qatar Biobank and genome sequence data provided by Qatar Genome Program. A trans-ancestry meta-analysis of data from our Qatari cohort with summary statistics from a previously published large cohort (9,758 subjects) of European ancestry was conducted. Using conditional analysis, we identified two independent single nucleotide polymorphisms (SNPs) associated with β-sitosterol (rs145164937 and rs4299376), and two others with campesterol (rs7598542 and rs75901165) in the Qatari population in addition to previously reported variants. All of them map to the ABCG5/8 locus except rs75901165 which is located within the Intraflagellar Transport 43 (IFT43) gene. The meta-analysis replicated most of the reported variants, and our study provided significant support for the association of variants in SCARB1 and ABO with sitosterolemia. We also evaluated the performance of a polygenic risk score for this trait from a European GWAS in QBB. These findings may have future implications on the personalized treatment of hyperlipidemia in general while showing the importance of building population-specific multi-omics databases.
Utilization of Evidence-Based Therapies and prescribing patterns among patients receiving anti- hypertensive agents in Hospital Serdang
Authors: Marzouk Mennatallah , Hisham Shairyzah 
Published: March 2024

Abstract
Introduction: Hypertension is recognized as a major global problem. It affects every aspect of the patient’s quality of life, and employment and can even cause premature death. Its growing prevalence and poor control represent a huge health challenge worldwide.
Objectives: This study was designed to evaluate the utilization of evidence-based anti-hypertensive agents in the management of hypertensive patients in Hospital Serdang. This study was conducted retrospectively from July 2019 to August 2019.
Methodology: The study subjects were screened and reemitted using a random sampling method according to inclusion and exclusion criteria. Selected patient data was retrieved from Hospital Serdang's online eHIS Live system.
Results: Out of 106 patients, 14 patients were excluded due to incomplete information on medical records, patients following up at other hospitals, and pregnant women. The study results showed that adherence to the guidelines when prescribing combination therapies was seen more than in monotherapy. The majority of subjects did not receive antihypertensive treatment according to co-morbidities. However, only stroke showed high adherence to the guideline. Most of the subjects adhered to guidelines when there was a presence of contraindications. The median (IQR) GAI score was 40. In this study, GAI score was divided into 3 categories, 13 (15.9%) of the patients have a good adherence (80-100%), 23 (28%) have moderate adherence (50-79%) and 46 (56.11%) have poor adherence (0-49%) to the guideline.
Conclusion: Among 82 studied patients, more than half of the patients were not treated according to guidelines, while only 13 of the subjects were categorized as having good adherence to guidelines. This study indicated that there is a need to introduce an educational program for prescribers in hospitals and collaborative interventions between clinical pharmacist and physicians.
Non-linear optical properties, Quantum Chemical Calculations, Hirschfeld Surface, Molecular Docking Study on Anticancer Activity, NCI and ELF of α-P 4 S 4 a cage phosphorus-sulphorus
Authors: Rafik Abdellatif , Zouihri Hafid , Elhenawy Ahmed A. , Alam Seikh Mafiz , Islam Mohammad Shahidul , Guedira Taoufiq , Tüzün Burak 
Published: March 2024

Abstract
Computational investigations on α-P4S4, including molecular geometry optimization, Gaussian 03 software with B3LYP and MP2 methodologies was used to perform HOMO-LUMO analysis and Mulliken population analysis at the 6-311 + G(d,p) level. Hirshfeld maps and two-dimensional fingerprint plots show that S⋯S, S⋯P, and P⋯P interactions are most common. Second-order nonlinear optical (NLO) events are interpreted by means of electrically resonant second harmonic generating. A new diagrammatic technique provides for compact mapping the expected response of NLO as a function of molecule regards provides visual illustrations of the resonant NLO molecular response. Indeed, strong electron withdrawing P group on the cage ring. The HOMO-LUMO energy gap was measured to be 4.4283 eV. However, the findings indicate that α-P4S4 can be employed for diverse opto-electronic applications. The computed findings are in good accord with the experimental results. finally, by combining these approaches, it would be possible to better understand how the structure of α-P4S4, its Fourier density and its non-covalent interactions contribute to its potential anticancer activity, which could lead to the development of more effective drugs against cancer.
Involvement of the RhoA/ROCK signaling pathway in the pathogenesis of knee osteoarthritis
Authors: Yang Tianxiang , Wang Yi , Liu Zige , Zhang Bowen , Zhang Jinning , Yuan Ang , Wang Wenpeng , Chen Desheng 
Published: March 2024

Abstract
Purpose
This study compared the expression of the Ras homolog gene family member A (RhoA) and Rho-associated coiled-coil kinase (ROCK) signaling pathway members in knee joint synovial tissue from patients with primary knee osteoarthritis (KOA) who underwent lower limb disarticulation.
Methods
The specimens were separated into observation (synovial tissue removed during total knee arthroplasty of 30 patients with primary KOA) and control groups (synovial tissue removed during lower limb disarticulation of 25 patients).
Results
The observation group specimens showed high proliferation, congestion, edema, unorganized cellular arrangement, and presence of vacuolated cells. The control group specimens were white with a smooth surface and non-edematous texture, and showed organized and homogenous cell/stroma arrangement. The observation group showed higher expression of RhoA and ROCK transcripts and proteins than the control.
Conclusion
Patients with KOA expressed high levels of RhoA and ROCK transcripts and proteins in synovial tissues, suggesting a relationship between RhoA/ROCK and KOA. Our findings provide a potential therapeutic target for delaying synovial lesions in KOA.
Unconventional angular dependence of spin-orbit torque-induced harmonic Hall resistance in Pt/YIG bilayers
Authors: Park Byong-Guk , Shiino Takayuki , Phuoc Cao Van , Choi Jong-Guk , Kim Geunwoo , Jeong Jong-Ryul 
Published: March 2024

Abstract
Spin orbit torque (SOT), arising from spin-orbit coupling-induced spin currents, provides efficient control of the magnetization direction. SOT characterization that involves analyzing the first and second harmonic Hall resistances are typically done in a low-current regime, distinct from a high-current regime, where SOT-induced magnetization switching occurs. In this study, we investigate the azimuthal angle (ϕ)-dependent harmonic Hall resistances of a Pt/yttrium iron garnet (YIG) layer across a wide range of measurement currents. Under low-current conditions, conventional ϕ-dependent Hall resistances are observed; the first harmonic Hall resistance exhibits sin⁡2ϕ behavior and the second harmonic Hall resistance comprises cos⁡ϕ and cos⁡3ϕ terms, associated with damping-like and field-like SOT, respectively. Interestingly, with an increase in the current, higher-order angular-dependent terms become non-negligible, referring to the sin⁡4ϕ and sin⁡6ϕ terms for the first harmonic and the cos⁡5ϕ and cos⁡7ϕ terms for the second harmonic Hall resistances. We attribute this unconventional angular dependence to the nonlinear current dependence of SOT, emphasizing its relevance to understand the magnetization dynamics during SOT-induced switching under large currents.
Inhibition of Elastase induced Abdominal Aortic Aneurysm Progression through the CXCL12/CXCR4 Axis via MiR206 3p Sponge
Authors: Xuan Xuezhen , Li Yaling , Cao Genmao , Hu Jie , Yan Sheng , Jin Haijiang , Qiao Maolin , Zheng Lin , Zhang Ruijing , Dong Honglin 
Published: March 2024

Abstract
Background
Prior research has established a significant association between the progression of abdominal aortic aneurysms (AAA) and the apoptosis and phenotypic transformation of vascular smooth muscle cells (VSMCs). Notably, the CXCL12/CXCR4 signaling pathway's activation is markedly increased in a mouse model of AAA. Nonetheless, the precise contribution of this pathway to AAA development remains to be elucidated.
Materials and Methods
We utilized a single-cell sequencing dataset pertaining to AAA from the Gene Expression Omnibus database, employing the R package CellChat (v1.1.3) to analyze communication strength, signaling pathways, and modes of interaction among various VSMC phenotypes and immune cells. The activity level of the CXCL12/CXCR4 axis was evaluated in both human AAA patients and a mouse model. We examined the impact of CXCR4-specific inhibitors on AAA progression and the regulatory influence of MiR206-3p sponge on this axis.
Results
Single-cell RNA sequencing analysis revealed a significant upregulation of CXCL12/CXCR4 axis in AAA tissues. Further, Serum ELISA and in vivo experiments indicate a pronounced activation of the CXCL12/CXCR4 axis in both AAA patients and the elastase-induced AAA mouse model. CXCR4-specific inhibitors inhibited further expansion and rupture of the abdominal aorta and reduced the infiltration of macrophages in the aorta. Diminishing miR206-3p levels in VSMCs led to a decrease in CXCR4 expression within AAA tissues and a reduction in serum CXCL12 concentrations. Furthermore, transfecting VSMCs with miR206-3p sponge curtailed apoptosis and phenotypic transformation, markedly reducing AAA diameter and rupture frequency in mice. In vitro experiments corroborated that blocking the CXCL12/CXCR4 axis mitigated apoptosis and phenotypic transformation of VSMCs.
Conclusion
Our findings propose that MiR206-3p sponge represents an innovative therapeutic strategy to attenuate AAA progression and rupture risk, primarily through the suppression of the CXCL12/CXCR4 signaling pathway.
Investigating the role of a testis-expressed gene Tex2 in spermatogenesis in mice
Authors: Wang Suyan , Li Dingming , Shen Gan , Zhuo Liangchai , Ruan Tiechao , Wang Xiang , Jiang Chuan , Liu Yao , Jiang Xiaohui , Shen Ying 
Published: March 2024

Abstract
Background
Although TEX2 is primarily expressed in the testes of mammals, its exact role in reproduction remains unclear. This study aims to explore whether TEX2 plays a role in determining fertility in mice.
Methods
To address this issue, a mouse model with Tex2 knockout was created through CRISPR/Cas9 technology. Various experiments, including qPCR, Western blotting, immunofluorescence, electron microscopy, CASA, and H&E staining, were conducted to evaluate the role of TEX2 on mouse spermatogenesis.
Results
Although a percentage of spermatozoa exhibited defects in morphology and motility following Tex2 knockout, these abnormalities had no significant impact on the fertility of male mice. Additionally, the knockout did not significantly influence ovarian development or oogenesis in female mice.
Conclusions
In summary, despite the deletion of Tex2 having a minor impact on spermatogenesis in mice, it did not significantly affect their overall fertility. It is possible that alternative mechanisms might compensate for the absence of Tex2, or that Tex2 has a dispensable role in the reproductive process. This discovery offers a fresh outlook on the genetic regulatory mechanisms involved in the reproductive process, potentially catalyzing further investigations in related fields.