bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic impact of primary tumour location after curative resection in Stage I–III colorectal cancer: a single-centre retrospective study
Authors: Inoue Manabu , Kanemitsu Yukihide , Tsukamoto Shunsuke , Moritani Konosuke , Takamizawa Yasuyuki , Daiko Hiroyuki 
Published: March 2024

Abstract

Objective
The relationship of tumour site with post-recurrence course and outcome after primary surgery in resectable colorectal cancer is unclear. This study investigated the prognostic impact of primary tumour location following radical resection without preoperative treatment in Stage I–III colorectal cancer.

Methods
We analyzed 3770 patients with Stage I–III colorectal cancer who underwent curative resection at our hospital during 2000–15. We defined the right-sided colon as the cecum, ascending colon and transverse colon, and the left-sided colon as the descending colon, sigmoid and rectosigmoid junction. Patients were divided into three groups according to tumour site: right-sided colon, left-sided colon and rectum. Endpoints were overall survival, recurrence-free survival by stage and survival after recurrence, respectively.

Results
The 5-year overall survival rates of patients with stage I left-sided colon cancer, right-sided colon cancer and rectal cancer were 98.2, 97.3 and 97.2%, respectively (P = 0.488). The 5-year overall survival rates of patients with Stage II left-sided colon cancer, right-sided colon cancer and rectal cancer were 96.2, 88.7 and 83.0, respectively (P = 0.070). The 5-year overall survival rates of patients with Stage III left-sided colon cancer, right-sided colon cancer and rectal cancer were 88.7, 83.0 and 80.2, respectively (P = 0.001). The 5-year recurrence-free survival rates of patients with Stage I left-sided colon cancer, right-sided colon cancer and rectal cancer were 95.1, 94.5 and 90.6% (P = 0.027). The 5-year recurrence-free survival rates of patients with Stage II left-sided colon cancer, right-sided colon cancer and rectal cancer were 85.2, 90.2 and 76.1%, respectively (P &lt; 0.001). The 5-year recurrence-free survival rates of patients with Stage III left-sided colon cancer, right-sided colon cancer and rectal cancer were 75.3, 75.3 and 59.8%, respectively (P &lt; 0.001). Right-sided colon cancer was significantly associated with better recurrence-free survival compared with left-sided colon cancer (HR 1.29, 95% CI 1.03–1.63; P = 0.025) and rectal cancer (HR 1.89, 95% CI 1.51–2.38; P &lt; 0.001) after adjusting for clinical factors. Amongst patients with recurrence, right-sided colon cancer was significantly associated with poorer survival after recurrence compared with left-sided colon cancer (HR 0.68, 95% CI 0.48–0.97; P = 0.036), and showed a tendency towards poorer survival after recurrence compared with rectal cancer (HR 0.79, 95% CI 0.57–1.10; P = 0.164).

Conclusions
In Stage I–III colorectal cancer without preoperative treatment, our results suggest that the three tumour sites (right-sided colon, left-sided colon or rectum) may have prognostic significance for recurrence-free survival and survival after recurrence, rather than sidedness alone.
Adaptive religious coping with experiences of sexual and gender-based violence and displacement
Authors: Pertek Sandra 
Published: March 2024

Abstract
This article examines the religious coping strategies among forced migrant women survivors of sexual and gender-based violence (SGBV). While it is acknowledged that faith and religion help people to survive crises, the patterns of religious coping with SGBV and displacement are little understood. I explore how displaced women use their faith and religious resources to cope with SGBV and migration-related daily stressors. Using qualitative methods and data collected in Turkey and Tunisia with thirty-eight Levantine and African women, I introduce the concept of adaptive religious coping, which they deployed over time and place as one main coping mechanism in experiences of SGBV and displacement. Survivors used cognitive, behavioural and spiritual/emotional religious coping strategies, drawing on their available religious resources—ideas, practices and experience. The study highlights the importance of religious coping in supporting displaced populations emotionally and spiritually, and offers implications for mental health responses in forced displacement contexts.
(O-20) COMPARISON OF THREE SHOCKWAVE THERAPY PROTOCOLS FOR THE TREATMENT OF ERECTILE DYSFUNCTION
Authors: Corredor H , Martínez J M , Sandoval-Salinas C , Barba J , Patrón F 
Published: March 2024

Abstract

Introduction
Multiple treatment modalities have been used to treat erectile dysfunction (ED), including focal shock waves. This therapy has demonstrated a short-term positive effect in patients who respond or not to PDE-5i, with variability in therapeutic protocols.

Aim
To evaluate the effectiveness of 3 shock wave protocols for the treatment of ED.

Methods
Randomized, multicenter clinical trial. 277 men with non-psychological ED, over 18 years of age, without cancer or major surgeries in the pelvic area or any neurological disease that affected their erectile function, were randomized to one of three groups: weekly (6 wave sessions (WS), 1 x wk), monthly (6 WS 1 x month) or reinforcement (6 WS, 1 x week + 5 sessions, 1 x month). The wave parameters were the same in all groups, no patient received medication. The primary outcome was the change in IIEF-EF score at 6 months of follow-up. The change in the IIEF at the end of therapy and at 3 months of follow-up, erection hardness with the EHS, self-esteem with the SEAR questionnaire, and side effects were also evaluated.

Results
222 patients completed the study. In the 6-month evaluation, the average change in the IIEF-EF in the monthly schedule was 4.3 (+/-6.7), 1.9 (+/-6.5) in the weekly schedule, and 5.0 (+/-6.1) in the reinforcement schedule ( p=0.0086). At the end of therapy and at 3 months the change in the IIEF-EF was 3.2 (+/-5.8) and 2.9 (+/-5.5) in the monthly group, 2.7 (+/-4.5) and 3.0 (+/-5.3) in the weekly one, and 4.2 (+/-6.4) and 4.4 (+/-6.5) in the reinforcement one. No differences were found between the groups in the proportion of patients who increased at least one point in erection hardness, nor in the average in the SEAR questionnaire in the evaluations carried out. No patient reported adverse effects to the therapy.

Conclusions
The results suggest that monthly and reinforcement wave schemes present good results for the treatment of ED.

Financing
Boston Medical Group.
(O-23) EFFECTIVENESS OF COMPREHENSIVE TREATMENT FOR ERECTILE DYSFUNCTION WITH MEDICATION AND SHOCKWAVE THERAPY: A REAL-LIFE STUDY
Authors: Sandoval-Salinas C , Aristizábal O L , Martinez J M 
Published: March 2024

Abstract

Objective
To evaluate the effectiveness of adding shockwave therapy to pharmacological treatment in a cohort of men with erectile dysfunction in Colombia and Peru.

Methods
Observational cohort study. Patient records from those treated for erectile dysfunction in 2022 were reviewed. Patients over 18 years old, without other sexual dysfunctions were included. Changes in the IIEF-EF questionnaire score and the proportion of patients achieving penetration capability (EHS &gt;2) after treatment were assessed.

Results
317 patients met the criteria and were included in the analysis. 150 received medication only (group 1) and 167 received shockwave therapy + medication (group 2). The median duration of treatment was 4.8 months for group 1 and 5.6 months for group 2. The initial IIEF-EF score for group 1 was 15.8 (+/-5.4) and the average increase at the end of treatment was 7.35 (+/-5.4) points. In group 2, the initial IIEF-EF was 14.7 (+/-4.9) and the average increase was 7.47 (+/-5.8). At the end of treatment, 39.3% of patients in group 1 and 42.5% in group 2 reported no ED according to the IIEF-EF score. The proportion of patients who could not achieve penetration (EHS &lt;=2) before treatment and achieved sufficient rigidity for penetration (EHS &gt;2) after treatment was 85% in group 1 and 94% in group 2.

Conclusions
The additional use of shockwave therapy improves the outcomes of pharmacological treatment in patients with ED.

Financing
Boston Medical Group.
(O-41) PSYCHOEDUCATIONAL GROUP FOR MEN WITH PROSTATE CANCER
Authors: Silva I M , Naccarato A M E P , Campos JdAeS , Denardi F , Matheus W E , Ferreira U 
Published: March 2024

Abstract

The incidence of cancer in the world population in 2002 was estimated at 11 million new cases, in 2020 this estimate is approximately 20 million. Cancer is a global public health problem.
Prostate cancer (CaP) is a multifocal disease, with wide clinical variation among patients. The PCa survivors present unique chronic side effects compared to other cancer survivors, with challenges in achieving physical and social well-being, and satisfaction with life in general.
This work aims to evaluate the impact of psychotherapy, in an open group, on Health-Related Quality of Life (HRQoL) and Sexuality in patients with PCa who have undergone treatment. Data is been collected through an initial interview (Identification, Anamnesis, Health Anamnesis, Degree of Satisfaction with Life and Sexuality, Affective-Emotional Assessment and Treatment Data), SF-36 questionnaire and IIEF-5 short form, in patients who are diagnosed, have undergone treatment or are being monitored at the outpatient clinic, and reapplication in the last semester of the group's operation. At each session, 5 questions are answered regarding the perception of the previous session. The group will be available once a week for 2 years. The sessions last 90 minutes, led by the same psychologist. The research is been developed considering the ethical principles of secrecy, privacy, confidentiality and non-identification of interviewee data. The study will not pose any risks to the subjects and no invasive techniques will be used to deal with the body or psychological distress. Before starting the process, the Termo de Consentimento Livre e Esclarecido (TCLE) is delivered, as well as the provision of all details regarding the research. It is also explained that participation is voluntary and that the participant may leave the research at any time, without this causing any harm to their treatment and follow-up.

Financing
No conflict.
(PM-02) GENITOURINARY TUBERCULOSIS IN MALE PATIENTS: A CASE SERIES FROM A FEDERAL UNIVERSITY HOSPITAL
Authors: Lima V F N , Feitosa V L , Haddad D J , Dettoni J B , Borges C F 
Published: March 2024

Abstract

Introduction
Tuberculosis is a significant global public health threat, causing 1.2 million deaths in 2019. In Brazil, the incidence of the disease in the same year was 46 new cases per 100,000 inhabitants. Genitourinary tuberculosis is the third most common form of extrapulmonary tuberculosis, resulting from the spread of mycobacteria through hematogenous dissemination from a latent chronic pulmonary infection or by local spread.

Objective
This study aims to present a case series of genitourinary tuberculosis in male patients from a tertiary university hospital.

Method
The study conducted a descriptive analysis of a case series using data from the Unit of Pathological Anatomy Laboratory and the Center for Infectious Diseases between 1999 and 2020.

Results
Four male patients, with a mean age of 32 years (ranging from 23 to 46), were evaluated. Key symptoms reported during medical consultations at the Urology outpatient service included scrotal nodules, increased testicular volume, and orchialgia, with an average symptom duration of six months. Physical examinations revealed a hard nodular mass in the epididymis or upper testicular pole, mostly on the right side (in half of the cases) or the left side (in the other half). Histological examination of biopsies indicated chronic granulomatous inflammation consistent with tuberculoid in all cases, with negative tumor markers. Notably, none of the patients reported contact with tuberculosis or leprosy patients, and only one patient had a positive PPD test (&gt;24mm).

Conclusion
Genitourinary tuberculosis is a treatable and preventable disease. Understanding its clinical aspects, forms of presentation, dissemination, diagnosis, and treatment is crucial. Drug therapy, including rifampicin, isoniazid, pyrazinamide, and ethambutol, was effective in resolving symptoms in all patients. Surgical intervention in the form of orchidectomy was required for some cases, resulting in positive outcomes.

Financing
No conflict.
(PM-05) EFFICACY OF PELVIC FLOOR MUSCLE TRAINING AND PERINEAL MASSAGE IN THE TREATMENT OF WOMEN WITH DYSPAREUNIA: NARRATIVE REVIEW OF THE LITERATURE
Authors: Boraschi Gomes V , Fernandes Torres T , Merino D , Castiglione M , Pavione Rodrigues Pereira R , Tanaka C 
Published: March 2024

Abstract

Introduction
Sexual dysfunction is an alteration in one or more components of the sexual response cycle and dyspareunia is the dysfunction in which the woman experiences pain before, during or after vaginal penetration, which impairs quality of life and relationship with the couple. Physiotherapy uses several techniques to address this dysfunction, including pelvic floor muscle training (PFMT) and perineal massage (PM), but studies on the actual effects of these techniques and the resolution of dyspareunia are still scarce. Therefore, the objective of this study is to identify the evidence on the use of PFMT and MP techniques in the treatment of women with dyspareunia.

Materials/Methods
Research carried out in the PEDro, Pubmed and MEDLINE databases. Articles of the type were included: clinical trials, meta-analysis and systematic reviews, published in English and Portuguese; in the period from 2013 to 2023; who addressed TMAP and MP techniques in the treatment of dyspareunia. Those who did not meet the inclusion criteria were excluded.

Results
In total, 525 articles were identified, but only 9 studies were selected for this review as they met the inclusion criteria. Most of the results showed significant responses to treatment with the use of PFMT and MP, and even the studies in which they did not obtain significance did not rule out the possibility of these techniques, since they do not present side effects and have good potential. to improve. Many studies have low methodological quality.

Conclusion
It was observed in the literature that PFMT and MP have good responses in the treatment of dyspareunia, but there is not enough support in the literature to demonstrate their effectiveness. It is necessary to develop future studies with better methodological quality for more solid scientific evidence.

Financing
No conflict.
Variable effects of exposure to ionic silver in wound-associated bacterial pathogens
Authors: Binsuwaidan Reem , Almuzaini Osama , Mercer Steven , Doherty Christopher , Mokhtar Jawahir , McBain Andrew J , Ledder Ruth , Humphreys Gavin J 
Published: March 2024

Abstract
Silver compounds are used in wound dressings to reduce bioburden. Where infection is not rapidly resolved, bacteria may be exposed to sub-therapeutic concentrations of antimicrobials over prolonged periods of time. In this study, a panel of chronic wound bacteria, Pseudomonas aeruginosa (two strains), Staphylococcus aureus, and Escherichia coli, were exposed to silver nitrate on agar. Phenotypic characterization was achieved using broth microdilution sensitivity testing, a crystal violet biofilm assay, and a wax moth pathogenesis model. Repeated exposure to ionic silver did not result in planktonic phenotypic silver resistance in any of the test panels, although S. aureus demonstrated reversible increases in minimum bactericidal concentration. An ulcer-derived P. aeruginosa exhibited marked reductions in biofilm eradication concentration as well as significantly increased biofilm formation and wax moth killing when compared to the same progenitor. These changes were reversible, trending towards baseline measurements following 10 passages on silver-free media. Changes in virulence and biofilm formation in the other test bacteria were generally limited. In summary, phenotypic adaptation following exposure to ionic silver was manifested other than through changes in planktonic susceptibility. Significant changes in pseudomonas biofilm formation and sensitivity could have implications for wound care regimes and therefore warrant further investigation.
Identifying Risk Factors for Dental Emergency Visits in the US Army
Authors: Arbuckle Patrick J , Beltran Thomas , Reifenstahl Erik 
Published: March 2024

ABSTRACT

Introduction
The purpose of this study is to examine the relationship between subjects’ oral health characteristics and the incidence of a dental emergency over 1 year.

Materials and Methods
The Corporate Dental System (CDS) generated a limited data set for service members assigned for dental care at Fort Liberty, North Carolina. Data extracted included demographics and oral health characteristics (dental readiness classification, caries risk, periodontal screening and recording values (PSR), and tobacco use). Subjects were grouped based on the presence of a dental emergency visit code in the past year.

Results
A total of 20,210 individuals were included in the sample; 8.5% of individuals sought emergency dental care during the period. Kruskal-Wallis tests found significant differences (P &lt; 0.05) in dental emergencies between age groups, sex, rank, dental readiness classification, and caries risk. Younger age, female soldiers, and low caries risk had the most significant increase in dental emergencies. There was no significant difference in dental emergencies between PSR or tobacco usage groups.

Conclusion
This study supports a relationship between demographics, oral health characteristics, and dental emergencies. Age may be related to service members entering the military with untreated or managed dental needs, notably around the age of third molar eruption. Sex differences may be related to willingness or preference to utilize non-emergency dental care visits. The inverse relationship between caries risk and dental emergencies could be due to identification and management of high caries risk patients. This project highlights the need for further study and increasingly discrete measurement of oral health care characteristics and coding for etiologies of dental emergencies.
Don’t Overlook Syphilis: An Atypical Rash in a Woman With Neurologic, Ocular, and Otic Involvement
Authors: Crouch Elena M , Stein Michael T O , Geringer Matthew R , Weiss Aeja , Stalons Molly , Geringer Jamie L 
Published: March 2024

ABSTRACT
The manifestations of syphilis, a sexually transmitted infection caused by Treponema pallidum, can be divided into primary, secondary, or tertiary stages. In addition, syphilis can cause a latent infection with no clinical manifestations and be diagnosed solely by serologic testing. Secondary syphilis is especially known for causing a rash and diverse clinical manifestation which can make its diagnosis challenging—particularly in patients whose medical and sexual histories do not align with the classical epidemiologic and textbook description of secondary syphilis. We present a case of a 20-year-old immunocompetent heterosexual woman who presented with a rash atypical for secondary syphilis and accompanied by neurologic, ocular, and otic manifestations. This case highlights the importance of considering syphilis in the differential diagnosis of sexually active patients with a rash, even when their clinical presentations do not align with the textbook description of a syphilitic rash. Health care providers must remain vigilant for the diagnosis of syphilis in diverse clinical contexts, as early recognition and treatment are vital to prevent further syphilitic complications and transmission in military and civilian populations. Timely identification and intervention are crucial for both patient care and public health.
Female-Specific Health Care of Military Female-Designated Service Members and Veterans: A Systematic Overview of Reviews
Authors: McDermott Megan C , Musilli Megan G , Brown Jill E , Melton John L , Miller Michael J , Allard Rhonda J , Lutgendorf Monica A 
Published: March 2024

ABSTRACT

Introduction
Since the War in Afghanistan began in 2001, service members have faced significant health effects related to service during war, with female-designated service members facing unique challenges. Numerous high-quality review articles have been published on the health and care of female-designated service members and veterans. Given the increasing volume of literature, we completed an overview of reviews on the health and health care of female-designated military populations. Our objective was to conduct an overview of reviews on the obstetrics and gynecologic health and health care of female-designated military populations since 2000 to understand female-specific health consequences of military service during war and make clinical recommendations.

Materials and Methods
On May 10, 2022, a medical librarian performed a comprehensive search across five databases (Ovid Medline, Embase, CINAHL, PsycINFO, Ovid All EBM Reviews, and Web of Science) for all relevant reviews published from 2000 to May 10, 2022. Results were limited to English language. After the removal of duplicates, 2,438 records were reviewed, and 69 studies were included in the final review. The search strategy and methods were registered with PROSPERO and are reported according to the Preferred Reporting Items for Overviews of Reviews (PRIOR) guidelines. Two independent reviewers conducted title and abstract screening and subsequent full text review using Covidence Systematic Review Software. Reviews addressing female-specific and obstetrics and gynecologic health of female-designated service members or veterans, utilizing a clear and systematic methodology, were eligible for inclusion. Quality assessment was conducted by teams of two reviewers.

Results
A total of 69 studies were included in the final review. Themes included mental health and impact of sexual assault on service members or veterans, veteran health care, issues of menstruation, pregnancy, and urogenital concerns. Areas with few reviews included occupational risks of military service and impact on obstetric outcomes, eating disorders, and menopause. There were insufficient or no reviews on the impact of military service on fertility, access to abortion care, reproductive health outcomes of lesbian, bisexual and transgender service members, surgical treatment of gynecologic conditions, and screening and treatment for breast, gynecologic, and non-pelvic organ cancers.

Conclusions
Female-designated military populations serving during periods of war face unique health challenges that should be considered in screening practices and the delivery of trauma informed care. Further research and reviews are needed for female-specific oncology, fertility, abortion access, and sexual and non-binary and expansive gender identities to better capture female-designated service member and veteran health during wartime and beyond.