bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Significance of HMGB1 and Autophagy‐Related Genes in Sinonasal Inverted Papilloma
Authors: Zi Jiajia , Wei Zhaoxia , Wang Lin , Yan Xudong , Zhang Shengnan , Zhao Lijuan , Li Danyang , Dong Zihui , Yu Longgang , Jiang Yan 
Published: March 2024

ObjectivesSinonasal inverted papilloma (SNIP) is a noncancerous tumor that develops in the mucous membrane of the nasal sinuses. Many malignancies are tightly linked to autophagy, an intracellular self‐degradation mechanism. HMGB1 has demonstrated its ability to modulate autophagy in many pathological conditions. This work investigates how HMGB1 and other genes involved in autophagy contribute to SNIP.Material and MethodsThe study included 45 patients with SNIP and a control group consisting of 28 individuals. In each group, qPCR was employed to examine the mRNA expression levels of genes correlated with autophagy and HMGB1. HMGB1 and genes associated with autophagy were examined for protein expression levels via Western Blot and immunohistochemical staining assays. At the same time, the association between HMGB1 and genes involved in autophagy was discovered through correlation analysis. Furthermore, Krouse staging was utilized for investigating the expression levels of HMGB1 and other autophagy‐related genes at various stages in clinically staged SNIP patients.ResultsLC3B, ATG5, and Beclin1 autophagy‐related genes and HMGB1 were substantially expressed in SNIP. Additionally, there was a positive correlation between HMGB1 and these genes. During various phases of SNIP, the levels of HMGB1 expression and autophagy‐related genes were notably elevated at stage T4 compared with stage T2.ConclusionClinical staging in SNIP is correlated with HMGB1 expression in conjunction with autophagy‐related genes LC3B, ATG5, and Beclin1, suggesting the possibility of novel prognostic indicators.Level of EvidenceNA Laryngoscope, 134:3941–3946, 2024
Endpoint estimates for harmonic analysis operators associated with Laguerre polynomial expansions
Authors: Betancor Jorge J. , Dalmasso Estefanía , Quijano Pablo , Scotto Roberto 
Published: March 2024

AbstractIn this paper, we give a criterion to prove boundedness results for several operators from the Hardy‐type space to and also from to the space of functions of bounded mean oscillation , with respect to the probability measure on when is a multi‐index in . We shall apply it to establish endpoint estimates for Riesz transforms, maximal operators, Littlewood–Paley functions, multipliers of the Laplace transform type, fractional integrals, and variation operators in the Laguerre setting.
Gravity modelling by using vertical prismatic polyhedra and application to a sedimentary basin in Eastern Anatolia
Authors: Aydın Nedim Gökhan , İşseven Turgay 
Published: March 2024

AbstractThere are various methods suggested for modelling the geometry of sedimentary basins by using gravity anomalies in the literature. When dealing with datasets that are non‐uniformly distributed across a study area, the choice of modelling method can significantly impact data reliability and computational resource usage. In this study, we present a gravity modelling approach utilizing prismatic vertical polyhedra. First, we summarize the requirement of such a method by highlighting limitations associated with a commonly employed modelling method that uses rectangular grid‐following vertical prisms for modelling. By contrast, we propose a method that adapts a polygonal mesh to the distribution of input gravity data points, each polygonal mesh cell containing one data point and using polygonal grid‐following vertical prisms for gravity modelling. To validate our method, we conduct tests using two synthetically constructed subsurface models – one featuring a normal fault and the other a deep basin. These are used to generate synthetic gravity observation data at irregularly spaced points that broadly follow the geology. The data are then inverted for obtaining subsurface structures by modelling with (a) rectangular prisms on a regular grid and (b) with our polygonal prisms on the tessellated grid. The inversion process involves calculating the heights of the prisms in both approaches, assuming a constant density contrast. The comparative analysis demonstrates the superior effectiveness of our approach (b). Finally, we apply our newly developed method to real gravity data recently collected from Gezin province, situated in the north‐eastern region of the Lake Hazar pull‐apart basin in Eastern Turkey. Our modelling results reveal previously underestimated basin geometry, suggesting the presence of an additional, previously unidentified fault to the east of Gezin, which forms the southern boundary of the basin.
Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes
Authors: Schulte Josh , Peterson Kyle , Thomsen Timothy , Lentz Steven , Hall Mederic , Slayman Tyler 
Published: March 2024

AbstractObjectiveTo compare the effectiveness, compliance, and side effect profile between daily or three times weekly (TIW) oral iron supplementation regimens in treating iron deficiency nonanemia (IDNA) in National Collegiate Athletic Association (NCAA) Division 1 female track and field or soccer athletes.DesignProspective cohort study.SettingDivision 1 collegiate athletics.ParticipantsThirty‐three NCAA Division 1 female athletes (18 track and field, 15 soccer).InterventionsDaily or TIW dosing of ferrous bisglycinate.Main Outcome MeasuresSerum ferritin (μg/L) was measured before and after 8 weeks of supplementation. Self‐reported compliance and side effect profile was assessed by electronic survey every 2 weeks.ResultsThe average main effect for the TIW regimen was a significant increase of 5.17 μg/L (95% CI: 0.86–9.47) in serum ferritin (p = .02). The average main effect for the daily regimen was a significant increase of 12.88 μg/L (95% CI: 4.84–20.93) in serum ferritin (p = .003). The estimated average effect of the treatment on the treated between regimens was a nonsignificant decrease of −7.17 μg/L (95% CI: −19.02 – 3.59) in serum ferritin (p = .17). Thus, the TIW regimen increased serum ferritin 7.17 units less than the daily regimen on average after 8 weeks of supplementation. The athletes following the daily regimen experienced significantly more nausea (p = .04) and constipation (p = .002) compared to the TIW regimen. There was no statistical difference in compliance between the two groups (p = .14).ConclusionsBoth the daily and TIW regimens increased serum ferritin. Compared to the daily regimen, the TIW regimen produced a smaller increase in serum ferritin but less nausea and constipation.
“A bloodless social revolution”: Land reform and multiple cropping in Cold War Taiwan, 1950–1979
Authors: Chu Leo 
Published: March 2024

Societal Impact StatementMultiple cropping, the cultivation of several crops on the same land in a year, occupied an important part of Taiwan's agricultural research from 1950 to 1970. This research originated in the context of Taiwan's land reform and diversification programs and their connections to the government's political ambition to maximize food production. The study of how multiple cropping was politicized and depoliticized by different actors helps to expand the narratives of the Green Revolution in Asia, analyze their legacies, and highlight Taiwan's role in the international exchange of visions of agricultural development during the Cold War.Summary
Scholars have recently expanded the history of the Green Revolution to move beyond the narrative of North–South technological diffusion. This article enriches the scholarship with the case of multiple cropping in Taiwan and its connection to Cold War geopolitics.
Rice productivity in postwar Taiwan was boosted through a land reform launched by the Sino‐American Joint Commission on Rural Reconstruction (JCRR) in the 1950s. Backed by American aid and staffed by scientists from the Republic of China (ROC) government, the JCRR envisioned to turn tenant farmers into landowners so as to encourage labor input and adoption of seeds and fertilizers.
By 1960, the JCRR presented its reform as a “bloodless social revolution” and extended its focus to multiple cropping through a diversification program. The JCRR further created the Asian Vegetable Research and Development Center (AVRDC) in 1971 to spread Taiwan's breeding and cropping techniques. The ROC's diplomatic isolation in the 1970s, however, prompted the center to reinterpret Taiwan's success in multiple cropping from a political achievement to a technological triumph, thus reinforcing the technology‐driven narrative used by the International Rice Research Institute (IRRI).
Through Taiwan's influences on IRRI's rice breeding and multiple cropping research, this paper illustrates that the history of the Green Revolution requires more complex narratives. In addition, with Taiwan's political and economic transition since the 1980s, farmers began to reclaim their voice and influence agricultural policies. The case thus highlights the need of democratic participation in agricultural research, a concern that remains relevant today.
Mask interfaces and devices for home noninvasive ventilation in children
Authors: Khirani Sonia , Ducrot Vivian 
Published: March 2024

AbstractHome noninvasive ventilation (NIV), including continuous (CPAP) and bilevel (BPAP) positive airway pressure, is increasingly used in children worldwide. In this narrative review, we present a comprehensive summary of the equipment available for home NIV in pediatrics, excluding neonates. NIV may be challenging in young children, as the majority of the equipment has been developed for adults. Regarding the interfaces, only a few masks have been specifically developed for young children in recent years, while older children may benefit from a large variety of interfaces. Even though much progress has been made, skin injuries are still present, and need to be managed rapidly. Several studies addressed the management of the side effects, but recent studies are lacking regarding orofacial anomalies. No recent study reported the available interfaces for young children and the strategies for an optimal mask fit. Regarding the devices, an adapted NIV device to pediatrics that allows an adequate patient's breathing detection should guarantee optimal ventilatory efficiency and monitoring of NIV. A close follow‐up and regular monitoring should be mandatory to rule out the potential issues, optimize NIV therapy and ascertain the efficacy of NIV. However, studies are lacking to guide the choice of devices in young children and the optimal management of home NIV in pediatrics. We summarized the characteristics of the different interfaces available for young children and the limitations of NIV devices. We finally addressed potential areas for future research on long‐term home NIV in children.
Pediatric pulmonology year in review 2023: Physiology
Authors: Boas Heather , Ren Clement L. 
Published: March 2024

AbstractApplication of the principles of pulmonary physiology and lung development to the care and management of respiratory disease in children is a distinguishing feature of pediatric pulmonology. In 2023, this was evident in numerous publications in Pediatric Pulmonology and other journals. This review will highlight some of the papers in this area.
Quantification and molecular correlates of tertiary lymphoid structures in primary prostate cancer
Authors: Shahait Mohammed , Hakansson Alexander K. , Daniel Reba E. , Hosny Kareem , Davicioni Elai , Liu Seagle Yang , Sandberg Alex , Lee David I. , Lal Priti 
Published: March 2024

AbstractObjectiveTo morphologically describe tertiary lymphoid structures (TLS) in prostatectomy specimens and correlate them with clinical and transcriptomic features.MethodologyA total of 72 consecutive cases of entirely submitted radical prostatectomy (RP) patients tested with the Decipher Genomic Classifier were included in the study. Images were manually annotated using QuPath tools to denote tumor regions and each cluster of TLS. Clusters of lymphocytes that were surrounded on all four sides by tumor were defined as intra‐tumor TLS (IT‐TLS). Clusters of lymphocytes at the leading edge of carcinoma with either the prostatic pseudocapsule or benign parenchyma at one end were defined as peri‐tumor TLS (PT‐TLS). A classification algorithm to distinguish lymphocytes from non‐lymphocytic cells using a supervised machine learning model was used. The associations between TLS formation and 265 gene expression‐based signatures were examined.ResultsThe magnitude of total TLS correlations with primary tumor gene expression signatures was moderate (~0.35–0.5) with several HLA, T‐cell and B‐cell Cluster signatures, showing positive correlation with various metrics for quantification of TLS. On the other hand, immune suppressive signatures (Treg, MDSC) were negatively correlated. While signatures for macrophages, NK cells and other immune cell types were uncorrelated for the most part. PT‐TLS was associated with MHC signatures while IT TLS correlated with MHC and T‐cell signatures.ConclusionsClusters of inflammatory cells in the RP specimen can be divided spatially into PT TLS and IT‐TLS, each with its unique molecular correlates of tumor immune microenvironment. The presence of TLS is positively correlated with MHC signatures, T‐ cell and B‐cell cluster signatures but, negatively correlated with immune suppressive signatures. A subset of prostate cancer demonstrate a robust inflammatory response, and warrant further characterization in larger cohorts.
Lanthanum hydroxide protects kidney through gut microbiota in a rat model of chronic kidney disease
Authors: Gao Yuan , Wang Shengnan , Sun Lijun , Li Bing , Liu Hong , Bu Ren , Su Changhai , Guo Min , Liu Yang , Zhao Lulu , Gu Chao , Li Xiaojia , Yuan Xiaorong , Wang Qiwen , Li Gang 
Published: March 2024

AbstractThe progression of chronic kidney diseases (CKD) is complex, influenced by a myriad of factors including gut microbiota. While emerging evidence suggests that gut microbiota can have beneficial effects in managing CKD, it is also recognized that dysbiosis may contribute to the progression of CKD and associated uremic complications. Our previous research has demonstrated the efficacy of lanthanum hydroxide in delaying kidney failure and preserving renal function. However, the role of lanthanum hydroxide in modulating gut microbiota in this context remains unclear. In our study, we induced CKD in rats using adenine, leading to gut microbial dysbiosis, kidney pathology, and disturbances in amino acid metabolism. In this adenine‐induced CKD model with hyperphosphatemia, treatment with lanthanum hydroxide improved renal function. This improvement was associated with the restoration of gut microbial balance and an increase in urine ammonium metabolism. These results suggest that the therapeutic potential of lanthanum hydroxide in CKD may be partly due to its ability to reshape gut microbiota composition. This study underscores the significance of lanthanum hydroxide in kidney protection, attributing its benefits to the modulation of gut microbiota in a rat model of CKD.
A mixed uncertain structural reliability analysis method considering random and convex set variables with correlation
Authors: Ma Hang , Bi Junxi , Li Haibin , Ge Xinyu , Zhou Dachuan , Jiao Jiaming , Wang Guofu 
Published: March 2024

AbstractIn this paper, a mixed model reliability analysis method is put forward for the problem of assessing the reliability of complex engineering structures containing both random and convex aggregate variables. By integrating the ellipsoidal model with correlation and the interval model, the uncertainty region characterized by the ellipsoidal model with correlation is optimized with full consideration of the limited amount of engineering structure sample data, and the risk region represented by the reliability model is redefined, a new mixed reliability assessment criterion is established, and the minimum safe nonprobability reliability index of the structure is built. A key reference is offered by the safety limit diagram of constant reliability indexes set for the first time for the optimal design of engineering structure reliability. The proposed mixed reliability model is compared and analyzed with three classical models. The sensitivity of nonprobability reliability indexes, influenced by random variable parameters and correlation coefficients, is analyzed. This verification confirms that the new reliability model not only provides an accurate assessment of engineering structures' reliability but also lowers the computational demands of engineering design. In this paper, aero‐engine blades and wind turbine blades are taken as examples to expound the validity of the reliability model built using this method and its importance to the structural safety analysis of actual engineering.
The case of huge simple pulmonary aspergilloma that responded remarkably to drug therapy
Authors: Yokota Makoto , Takiguchi Junji , Tomioka Hiromi 
Published: March 2024

Key messageThe first choice of treatment for simple pulmonary aspergilloma is surgery, but in clinical practice, many cases find surgery difficult. We report a case of simple pulmonary aspergilloma in which significant improvement was observed with pharmacological treatment alone, despite initially presenting with a large fungus ball.
Compositional variable selection in quantile regression for microbiome data with false discovery rate control
Authors: Li Runze , Mu Jin , Yang Songshan , Ye Cong , Zhan Xiang 
Published: March 2024

AbstractAdvancement in high‐throughput sequencing technologies has stimulated intensive research interests to identify specific microbial taxa that are associated with disease conditions. Such knowledge is invaluable both from the perspective of understanding biology and from the biomedical perspective of therapeutic development, as the microbiome is inherently modifiable. Despite availability of massive data, analysis of microbiome compositional data remains difficult. The nature that relative abundances of all components of a microbial community sum to one poses challenges for statistical analysis, especially in high‐dimensional settings, where a common research theme is to select a small fraction of signals from amid many noisy features. Motivated by studies examining the role of microbiome in host transcriptomics, we propose a novel approach to identify microbial taxa that are associated with host gene expressions. Besides accommodating compositional nature of microbiome data, our method both achieves FDR‐controlled variable selection, and captures heterogeneity due to either heteroscedastic variance or non‐location‐scale covariate effects displayed in the motivating dataset. We demonstrate the superior performance of our method using extensive numerical simulation studies and then apply it to real‐world microbiome data analysis to gain novel biological insights that are missed by traditional mean‐based linear regression analysis.
Harnessing the Synergetic Effects of Ag, Mn Dopants in Eco‐Friendly Ultraviolet Selective Quantum Dots for Luminescent Solar Concentrators
Authors: Jin Lei , Hamzehpoor Ehsan , Selopal Gurpreet Singh , Liu Jiabin , Kumar Pawan , Benetti Daniele , Tong Xin , Perepichka Dmytro F. , Wang Zhiming M. , Rosei Federico 
Published: March 2024

AbstractQuantum dots (QDs) are promising building blocks for luminescent solar concentrators (LSCs), yet most QD‐based LSCs suffer from toxic metal composition and color tinting. UV‐selective harvesting QDs can enable visible transparency, but their development is restricted by large reabsorption losses and low photoluminescence quantum yield (PLQY). The developed here Ag, Mn: ZnInS2/ZnS QDs show a high PLQY of 53% due to the passivating effect of ZnS shell. These QDs selectively absorb UV light and emit orange‐red light with a large Stokes shift of 180 nm. A LSC of 5 × 5 × 0.2 cm3, fabricated using a poly(lauryl methacrylate) (PLMA) as a matrix, maintains 87% of integrated PL after 7 h of UV exposure. The QD‐PLMA achieved 90.7% average visible transparency (AVT) and a color rendering index (CRI) of 95.8, which is close to plain PLMA (AVT = 90.8%; CRI = 99.5), yielding excellent visible light transparency. Incorporating Si‐PVs at LSC edges, the Ag, Mn: ZIS/ZnS QD‐LSC achieved an optical efficiency of 1.42%, ranking competitively among high‐performing UV‐harvesting LSCs.
Extending the theory of planned behavior with government support and perceived risk to test the adoption of light electric vehicles in Tainan
Authors: Fouad Mohamed Tamer Z. 
Published: March 2024

AbstractTaiwan has become a pioneer in light electric vehicles (LEVs) despite limited government support (GS) and the perceived risks (PR) that discouraged the public from buying them. This article aims to confirm these two factors as key determinants for LEV adoption in Taiwan. The method relies on confirmatory factor analysis and structural equation modeling to test the behavioral intention (BI) of Tainan youth to adopt LEVs. In particular, the method extends the theory of planned behavior by addressing GS and PR while testing behavioral control (BC) as mediator and demographics as moderator. The report's findings confirm the mediating role of BC but do not confirm the effect of subjective norm. Young adults emphasized GS as a key factor influencing their adoption of LEVs. These findings are further discussed to bridge literature gaps of early stage adoption. The article also explores the implications of its research findings and offers recommendations for future research.
Delayed haemolytic transfusion reaction in a Lhasa Apso with Dal– blood type
Authors: Walton Jenny Elizabeth , Euler Catharina Cynthia , Giger Urs , Tappin Simon , Hale Anne S. 
Published: March 2024

AbstractAn adult Lhasa Apso presented with non‐regenerative immune‐mediated anaemia received DEA 1+ type‐matched blood and immunosuppressive therapy. After initially responding well, anaemia recurred. A rapid decline in packed cell volume occurred 18 days post‐transfusion, and because of this, a delayed haemolytic transfusion reaction (DHTR) was suspected. Major crossmatches performed subsequent to the suspected DHTR were incompatible to all available DEA 1+ and DEA 1– blood units (64 standard large breed donors). Additional crossmatching and extended typing was performed against 16 volunteer donors of the recipient's breed, including one sibling. The recipient and the compatible donors were typed as Dal–, and nine incompatible donors were typed as Dal+. The anaemic dog responded to medical treatment and was managed without further transfusions. This case documents a first likely delayed haemolytic transfusion reaction against the Dal blood type and a high incidence of Dal– Lhasa Apsos in the northeast of England.
Retained urethral catheter forming a closed loop secondary to excessive length in a cat: A non‐invasive technique to unwind and remove the loop
Authors: Amalbert Tancrède 
Published: March 2024

AbstractA polytraumatised, 5‐year‐old, neutered, male cat was diagnosed with a retained urethral catheter due to inadvertent excessive catheter insertion. The catheter formed a closed loop within the urinary bladder with the distal end travelling antegrade along the urethra. Unfortunately, first attempts to remove the catheter tightened the loop, preventing removal. Abdominal radiographs confirmed development of a loop obstructing the urethra. Careful palpation of the catheter residing in the urinary bladder was performed under general anaesthesia. The loop was unwound with external digital palpation and gentle cranial pulling. This technique avoided an emergency surgery in an already polytraumatised animal.The goal of this article is to describe a novel non‐invasive technique to safely withdraw a retained urinary catheter in cats. Clinical signs, differential diagnosis, risk factors, non‐invasive and invasive treatment options and prevention of a retained catheter are discussed.