bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, structural, and immuno‐analytical properties of antigenic bioconjugates comprising a β‐amyloid‐plaque specific epitope
Authors: Manea Marilena , Przybylski Michael , Hudecz Ferenc , Mezö Gábor 
Published: January 2008

AbstractImmunotherapeutic approaches are investigated for treatment of neurodegenerative diseases of the Alzheimer's dementia (AD) type. The identification of a β‐amyloid‐plaque specific epitope, Aβ(4‐10) (4FRHDSGY10), recognized by therapeutically active antibodies from transgenic AD mice could provide the basis for the development of AD vaccines. Here we report on the synthesis, structural and immuno‐analytical characterization of bioconjugates comprising the β‐amyloid(4‐10) epitope as new vaccine lead structures against Alzheimer's disease. To produce antigenic bioconjugates, potential immunogens, the epitope peptide elongated by a cysteine residue or a cysteinyl‐pentaglycine hexapeptide unit either at the N‐ or C‐terminus was attached via a thioether bond to synthetic oligopeptide carriers, such as oligotuftsin derivatives, sequential oligopeptide carrier, or lysine dendrimer. The antigenic properties of these constructs were determined by enzyme‐linked immunosorbent assay (ELISA) using an anti‐Aβ(1‐17) monoclonal antibody. Our results indicate that the major factors which influence the antibody binding of the Aβ(4‐10) epitope are (i) the epitope topology and (ii) the presence of a spacer moiety between the carrier and the epitope peptide. Interestingly, the carrier type had no marked effect on the binding of the antibody to the epitope‐conjugates. The conformational preferences of the conjugates were examined by circular dichroism spectroscopy in water and in trifluoroethanol. In water, the conjugates adopt random coil conformation independently on their primary structure. However, differences related to the attachment site of the epitope to the carriers were determined in TFE, conjugates in which the epitope was attached to the carrier through the N‐terminus exhibiting more ordered secondary structure. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 94–104, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Biophysical Properties of CDAN/DOPE‐Analogue Lipoplexes Account for Enhanced Gene Delivery
Authors: Fletcher Steven , Ahmad Ayesha , Price Wayne S. , Jorgensen Michael R. , Miller Andrew D. 
Published: January 2008

AbstractTypically, cationic liposomes are formulated from the combination of a synthetic cationic lipid (cytofectin) and a neutral, biologically available co‐lipid. However, the use of cationic liposome formulations to mediate gene delivery to cells is hampered by a paradox. Cationic lipids, such as N1‐cholesteryloxycarbonyl‐3‐7‐diazanonane‐1,9‐diamine (CDAN), are needed to ensure the formation of cationic liposome‐DNA (lipoplex, LD) particles by plasmid DNA (pDNA) condensation, as well as for efficient cell binding of LD particles and intracellular trafficking of pDNA post‐intracellular delivery by endocytosis. However, the same cationic lipids can exhibit toxicity, and also promote LD particle colloidal instability, leading to aggregation. This results from electrostatic interactions with anionic agents in biological fluids, particularly in vivo. One of the most commonly used neutral, bioavailable co‐lipids, dioleoyl L‐α‐phosphatidylethanolamine (DOPE), has been incorporated into many cationic liposome formulations owing to its fusogenic characteristics that are associated with a preference for the inverted hexagonal (HII) phase—a phase typical of membrane–membrane fusion events. However, these same fusogenic characteristics also destabilize LD particles substantially with respect to aggregation, in vitro and especially in vivo. Therefore, there is a real need to engineer more stable cationic liposome systems with lower cellular toxicity. We hypothesize that one way to achieve this goal should be to find the means to reduce the mol fraction of cationic lipid in cationic liposomes without impairing the overall transfection efficiency, by replacing DOPE with an alternative co‐lipid with fusogenic properties “tuned” with a greater preference for the more stable lamellar phases than DOPE is able to achieve. Herein, we document the syntheses of triple bond variants of DOPE, and their formulation into a range of low charge, low cationic lipid containing LD systems. The first indications are that our hypothesis is correct in vitro.
A New Strategy for Designing Non‐C2‐Symmetric Monometallic Bifunctional Catalysts and Their Application in Enantioselective Cyanation of Aldehydes
Authors: Yang Fei , Wei Siping , Chen Chien‐An , Xi Peihua , Yang Li , Lan Jingbo , Gau Han‐Mou , You Jingsong 
Published: January 2008

AbstractA monometallic bifunctional catalyst, in which only one imidazolyl moiety is directly attached at the 3‐position of a binaphthol moiety, has been developed. The ligand (R)‐1, which lacks C2‐symmetry and flexible linkers, in combination with Ti(OiPr)4, has been demonstrated to promote the enantioselective cyanation of aldehydes with trimethylsilylcyanide (TMSCN), giving excellent enantioselectivities of up to 98 % ee and high yields of up to 99 %. The use of this bifunctional catalytic system obviates the need for additives and is extremely simple as the reagents are added in one portion at the beginning of the reaction. The protocol has been found to tolerate a relatively wide range of aldehydes when 10 mol % of the (R)‐1/Ti(OiPr)4 complex is deployed in CH2Cl2 at −40 °C, the conditions which proved most practical and effective. The asymmetric cyanations also proceeded with lower catalyst loadings (5 mol %, or even 2 mol %), still giving satisfactory enantiomeric excesses and yields. Interestingly, the use of freshly distilled TMSCN dried over CaH2 gave a low enantioselectivity and only a moderate yield of the adduct as compared with direct use of the commercial reagent. The results of 13C NMR spectroscopic studies implicate HCN as the actual reactive nucleophile.
ChemInform Abstract: Four New Hydroxymonophosphates with Closely Related Intersecting Tunnels Structures: The Series AMIII(PO3(OH))2 with A: Rb, Cs; M: Fe, Al, Ga, In.
Authors: Lesage J. , Adam L. , Guesdon A. , Raveau B. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure of Ln1/3NbO3 (Ln: Nd, Pr) and Phase Transition in Nd1/3NbO3.
Authors: Zhang Zhaoming , Howard Christopher J. , Kennedy Brendan J. , Knight Kevin S. , Zhou Qingdi 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Class of Aeschynite Structure LaNbTiO6‐Based Orange‐Red Phosphors via a Modified Combustion Approach.
Authors: Ma Qian , Zhang Aiyu , Lue Mengkai , Zhou Yuanyuan , Qiu Zifeng , Zhou Guangjun 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Structural Study on the As—P—S Glassy System.
Authors: Santagneli S. H. , Skripatchev I. , Ribeiro S. J. L. , Messaddeq Y. , Schneider J. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure and Thermoelectric Properties of a New Carbide Zr2[Al3.56Si0.44]C5.
Authors: Fukuda Koichiro , Hisamura Miyuki , Iwata Tomoyuki , Tera Nobuyuki , Sato Kimiyasu 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Comparison of the Spin Exchange Interactions in PbCu2(PO4)2 and SrCu2(PO4)2 on the Basis of Spin Dimer Analysis.
Authors: Koo Hyun‐Joo , Kang Myoung‐Hee 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Cathode Materials for Rechargeable Mg Batteries: Fast Mg Ion Transport and Reversible Copper Extrusion in CuyMo6S8 Compounds.
Authors: Mitelman A. , Levi M. D. , Lancry E. , Levi E. , Aurbach D. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two‐Dimensional Layer Architecture Assembled by Keggin Polyoxotungstate, Cu(II)—EDTA Complex and Sodium Linker: Synthesis, Crystal Structures, and Magnetic Properties.
Authors: Liu Hong , Xu Lin , Gao Guang‐Gang , Li Feng‐Yan , Yang Yan‐Yan , Li Zhi‐Kui , Sun Yu 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diol Desymmetrization as an Approach to the Synthesis of Unsymmetrical Dienyl Diesters.
Authors: Phillips David J. , Pillinger Kathryn S. , Li Wei , Taylor Angela E. , Graham Andrew E. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile and Chemo‐Selective Synthesis of Tertiary Alkyl Isothiocyanates from Alcohols.
Authors: Miyake Hideyoshi , Nakao Yuichi , Sasaki Mitsuru 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Accelerated Claisen Rearrangement in Bicyclic Imidazolium [b‐3C‐im][NTf2] Ionic Liquid.
Authors: Lin Yung‐Lun , Cheng Jen‐Yen , Chu Yen‐Ho 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Chiral Quaternary Ammonium Salt and Triethylamine.
Authors: Peng Dan , Zhou Hui , Liu Xiaohua , Wang Liwei , Chen Shikui , Feng Xiaoming 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Environmentally Benign Oxidation of Some Organic Sulfides with 34% Hydrogen Peroxide Catalyzed by Simple Heteropolyoxometalates.
Authors: Tayebee Reza , Alizadeh Mohammad Hassan 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling of Arenediazonium Salts with Arylboronic Acids Catalyzed by a Recyclable Polymer‐Supported N‐Heterocyclic Carbene—Palladium Catalyst.
Authors: Qin Yuancheng , Wei Wei , Luo Meiming 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple Method for the Synthesis of Esters of 2‐Hydroxy‐3‐oxo‐2,3‐dihydrofuran‐2‐ylacetic Acid.
Authors: Kozminykh E. N. , Goncharov V. I. , Oborin D. B. , Kozminykh V. O. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantiomerically Pure Synthesis of β‐Substituted γ‐Butyrolactones: A Key Intermediate to Concise Synthesis of Pregabalin.
Authors: Ok Taedong , Jeon Aram , Lee Joohee , Lim Jung Hak , Hong Chang Seop , Lee Hee‐Seung 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Furan Synthesis Using Heterogeneous Catalysis.
Authors: Hayes Simon J. , Knight David W. , Menzies Melanie D. , O'Halloran Mark , Tan Wen‐Fei 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrophilic Chemistry of Thia‐PAHs: Stable Carbocations (NMR and DFT), S‐Alkylated Onium Salts, Model Electrophilic Substitutions (Nitration and Bromination), and Mutagenicity Assay.
Authors: Laali Kenneth K. , Chun Joong‐Hyun , Okazaki Takao , Kumar Subodh , Borosky Gabriela L. , Swartz Carol 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transannular Rearrangement of Activated Lactams: Stereoselective Synthesis of Substituted Pyrrolidine‐2,4‐diones from Diketopiperazines.
Authors: Farran Daniel , Parrot Isabelle , Martinez Jean , Dewynter Georges 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Cyclocarbonylation for the Synthesis of Bicyclic 3‐Methylene‐1‐phthalimidoylbutyrolactams from Allene‐hydrazones Mediated by Mo(CO)6.
Authors: Kim Sang‐Hoon , Kang Eui Soo , Yu Chan‐Mo 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile One‐Pot Synthesis of 6‐Monosubstituted and 6,12‐Disubstituted 5,11‐Dihydroindolo[3,2‐b]carbazoles and Preparation of Various Functionalized Derivatives.
Authors: Gu Rong , Hameurlaine Ahmed , Dehaen Wim 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Kinesin Spindle Protein (KSP) Inhibitors. Part 6. Design and Synthesis of 3,5‐Diaryl‐4,5‐dihydropyrazole Amides as Potent Inhibitors of the Mitotic Kinesin KSP.
Authors: Coleman Paul J. , et al. et al. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Benzoxazole‐2‐ones, Benzothiazole‐2‐ones and Their 2‐Thione Derivatives: Efficient Conversion of 2‐Thione to 2‐Oxo Derivatives.
Authors: Singh M. S. , Singh Pallavi , Singh Shweta 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Asymmetric Synthesis of trans‐3,4‐Dimethyl‐4‐arylpiperidines.
Authors: Furkert Daniel P. , Husbands Stephen M. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Application of P‐Stereogenic Phosphines as Superior Reagents in the Asymmetric Aza‐Wittig Reaction.
Authors: Headley Catherine E. , Marsden Stephen P. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photo‐ and Thermochromic Spiranes. Part 29. New Photochromic Indolinospiropyrans Containing a Quinoline Fragment
Authors: Tkachev V. V. , Aldoshin S. M. , Sanina N. A. , Lukyanov B. S. , Minkin V. I. , Utenyshev A. N. , Khalanskiy K. N. , Alekseenko Yu. S. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 114. Synthesis and Structure of 6‐R‐5‐Hydroxy‐2,4‐dioxo‐2,3,4,6‐tetrahydrobenzo[c] [2,7]naphthyridine‐1‐carbonitriles (IV).
Authors: Ukrainets I. V. , Bereznyakova N. L. , Parshikov V. A. , Shishkina S. V. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 118. Synthesis, Structure, and Chemical Properties of 2‐Bromomethyl‐5‐oxo‐1,2‐dihydro‐5H‐oxazolo[3,2‐a]quinoline‐4‐carboxylic Acid and Its Ethyl Ester.
Authors: Ukrainets I. V. , Sidorenko L. V. , Gorokhova O. V. , Shishkina S. V. , Turov A. V. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Pyridazine‐Based Scaffolds as α‐Helix Mimetics.
Authors: Volonterio Alessandro , Moisan Lionel , Rebek Julius Jr. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and SAR of 2‐Aryl Pyrido[2,3‐d]pyrimidines as Potent mGlu5 Receptor Antagonists.
Authors: Wendt John A. , Deeter Susan D. , Bove Susan E. , Knauer Christopher S. , Brooker Rachel M. , Augelli‐Szafran Corinne E. , Schwarz Roy D. , Kinsora Jack J. , Kilgore Kenneth S. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heterocycles (h)‐Fused onto 4‐Oxoquinoline‐3‐carboxylic Acid. Part 3. Facile Synthesis and Antitumor Activity of Model Heterocycles [a]‐Fused onto Pyrido[2,3‐f]quinoxaline‐3‐carboxylic Acids.
Authors: Shuheil Mohammad Y. Abu , Hassuneh Mona R. , Al‐Hiari Yusuf M. , Qaisi Ali M. , El‐Abadelah Mustafa M. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Quinoxaline Based Thiazolidinones and Azetidinones.
Authors: Vyas D. A. , Chauhan N. A. , Parikh A. R. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.