bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate taxes, leverage, and investment: Evidence from Nazi‐occupied Netherlands
Authors: Fliers Philip T. , de Jong Abe , Stiphout‐Kramer Bert S. van 
Published: March 2024

AbstractWe examine the Netherlands around the Second World War, where the occupying Nazi regime overhauled the country's corporate tax regime and introduced a profit tax of 55 per cent. We estimate that the new tax regime cost investors at least 300 million guilders, an amount equivalent to 5 per cent of Dutch GDP in 1940. We demonstrate that the tax introduction changed the financing of Dutch businesses. In particular, we find strong evidence that debt financing increased because it provides a tax shelter. The changes in taxation also led to an after‐tax reduction in the cost of debt, which had large real effects on firm investment. After the end of the war, firms with more leverage had higher capital expenditures.
Coherent long‐term body‐size responses across all Northwest Atlantic herring populations to warming and environmental change despite contrasting harvest and ecological factors
Authors: Beaudry‐Sylvestre Manuelle , Benoît Hugues P. , Hutchings Jeffrey A. 
Published: March 2024

AbstractBody size is a key component of individual fitness and an important factor in the structure and functioning of populations and ecosystems. Disentangling the effects of environmental change, harvest and intra‐ and inter‐specific trophic effects on body size remains challenging for populations in the wild. Herring in the Northwest Atlantic provide a strong basis for evaluating hypotheses related to these drivers given that they have experienced significant warming and harvest over the past century, while also having been exposed to a wide range of other selective constraints across their range. Using data on mean length‐at‐age 4 for the sixteen principal populations over a period of 53 cohorts (1962–2014), we fitted a series of empirical models for temporal and between‐population variation in the response to changes in sea surface temperature. We find evidence for a unified cross‐population response in the form of a parabolic function according to which populations in naturally warmer environments have responded more negatively to increasing temperature compared with those in colder locations. Temporal variation in residuals from this function was highly coherent among populations, further suggesting a common response to a large‐scale environmental driver. The synchrony observed in this study system, despite strong differences in harvest and ecological histories among populations and over time, clearly indicates a dominant role of environmental change on size‐at‐age in wild populations, in contrast to commonly reported effects of fishing. This finding has important implications for the management of fisheries as it indicates that a key trait associated with population productivity may be under considerably less short‐term management control than currently assumed. Our study, overall, illustrates the need for a comparative approach within species for inferences concerning the many possible effects on body size of natural and anthropogenic drivers in the wild.
Bureaucratic sludge: Bureaucratic tasks and procedures leading to experiences of strain
Authors: Stenderup Rasmus 
Published: March 2024

AbstractIn light of the recent conceptual debate about the administrative burdens framework, this article introduces the ‘bureaucratic sludge framework’ as a complementary theoretical approach for social policy and public administration research. The framework enable researchers to pursue novel research questions about for instance the interplay between administrative procedures, informal bureaucratic practices and public employees' experiences of strain and thus addresses a conceptual gap in the field. The article presents a non‐normative conceptualisation, proposing a typology of bureaucratic tasks—information seeking, assessment, implementation, and emotional labour—that may impose cognitive‐affective strain. Finally, a research agenda is outlined, and the bureaucratic task typology is proposed as a conceptual point of departure for researchers to empirically explore and audit practical instances of bureaucratic sludge in their contexts to further theorise and advance our understanding of the phenomenon. Social welfare is considered as an especially fruitful context within which to pursue this research agenda.
Cancer biology in diabetes update: Focusing on antidiabetic drugs
Authors: Kawakita Emi , Kanasaki Keizo 
Published: March 2024

AbstractThe association of type 2 diabetes with certain cancer risk has been of great interest for years. However, the effect of diabetic medications on cancer development is not fully understood. Prospective clinical trials have not elucidated the long‐term influence of hypoglycemic drugs on cancer incidence and the safety for cancer‐bearing patients with diabetes, whereas numerous preclinical studies have shown that antidiabetic drugs could have an impact on carcinogenesis processes beyond the glycemic control effect. Because there is no evidence of the safety profile of antidiabetic agents on cancer biology, careful consideration would be required when prescribing any medicines to patients with diabetes and existing tumor. In this review, we discuss the potential influence of each diabetes therapy in cancer ‘initiation’, ‘promotion’ and ‘progression’.
Health impacts of new‐onset diabetes in women post‐gestational diabetes mellitus: Insights from Hong Kong's territory‐wide data
Authors: Zhang Xinge , Wu Hongjiang , Lau Eric SH , Fan Baoqi , Tsoi Kit Ying , Tam Claudia HT , Yang Aimin , Shi Mai , Chow Elaine , Kong Alice PS , Chan Juliana CN , Tam Wing Hung , Luk Andrea OY , Ma Ronald CW 
Published: March 2024

ABSTRACTAims/IntroductionTo determine the population health burden attributable to the development of diabetes among women with a history of gestational diabetes mellitus (GDM).Materials and MethodsWe conducted a retrospective analysis of women with a history of GDM attending the Hong Kong Hospital Authority between 2000 and 2019. The time‐varying population attributable fraction was calculated.ResultsA total of 76,181 women with a history of gestational diabetes mellitus were included, 6,606 of them developed diabetes during a median follow‐up of 8.6 years. The respective hazard ratios (95% confidence interval) among women with GDM who developed diabetes vs those with GDM only were 2.8 (2.2, 3.7) for cardiovascular disease (CVD), 4.8 (3.0, 7.7) for end‐stage kidney disease (ESKD), 2.2 (1.9, 2.6) for infection‐related hospitalization, and 1.8 (1.3, 2.4) for all‐cause mortality. The development of diabetes was associated with 1.3 (0.8, 1.7), 0.6 (0.3, 0.8), 3.2 (2.4, 4.0), and 0.5 (0.2, 0.9) additional incident cases per 1,000 person‐years, accounting for 24.0% (13.2%, 35.9%), 42.0% (22.5%, 58.8%), 10.8% (7.1%, 14.9%), and 6.0% (−3.1%, 16.1%) of absolute number of CVD, ESKD, infection‐related hospitalization, and all‐cause mortality over 20 years after GDM, respectively.ConclusionsDiabetes is a significant contributor to the population health burden of some clinical outcomes in women with a history of gestational diabetes mellitus, but other risk factors need to be considered.
Post‐load glucose is a stronger predictor of adverse pregnancy outcomes than first‐trimester HbA1c in women without gestational diabetes
Authors: Rajabi Shahin Keshtkar , Toghraee Elham , Nejatipour Golnoosh 
Published: March 2024

ABSTRACTAims/IntroductionA debate exists on the relation of adverse pregnancy outcomes with glycemic levels in early pregnancy. We aimed to investigate the association of maternal characteristics including post‐load glucose and first‐trimester HbA1c test results with adverse pregnancy outcomes in women without gestational diabetes mellitus.Materials and MethodsA dataset (January 2011 and September 2017) from a hospital prenatal clinic was explored to find the important predictors of adverse pregnancy outcomes using maternal characteristics and glucose assessments in mothers without gestational diabetes. We used two machine learning algorithms to capture nonlinearity in selecting important maternal characteristics and developed predictive models for each outcome. In total, 1,618 pregnant women were included in the analytic dataset with a mean (SD) age of 26.8 (3.5) years and gravida of 1.7 (0.9).ResultsImportant associations were detected between maternal features and primary cesarean section, fetal distress, premature rupture of membranes, macrosomia, small or large for gestational age, APGAR <7 at 1 or 5 min, hyperbilirubinemia, and poly‐ or oligo‐hydramnios. Overall, the predictive models showed good performance and large areas under the curves (0.732, 0.765, 0.646, 0.651, 0.730, 0.646, 0.684, 0.716, and 0.678, respectively). Specifically, they had high positive likelihood ratios.ConclusionsHigh glucose levels were associated with adverse pregnancy outcomes. Post‐load glucose was the most reliable test for predicting the outcomes. Overall, fasting blood sugar was of more predictive value than HbA1c. Our study showed that further research should account for the nonlinearity and interactions inherent in the data.
Metamorphic evolution and geological significance of Early Palaeozoic high‐pressure granulites from the East Kunlun (NW China)
Authors: Chen An‐Ping , Zhang Hong‐Fu , Zhang Ming‐Jie , Zhang Xiao‐Qi 
Published: March 2024

AbstractGranulites and eclogites are useful for revealing the thermal and tectonic evolution of orogens. Early Palaeozoic granulites and associated eclogites in the East Kunlun Orogenic Belt (EKOB) display contrasting metamorphic age. Such asynchronous granulite–eclogite associations have rarely been reported, and the geological significance of their existence remains to be further explored. In this study, petrological and geochronological techniques were used to investigate two felsic and two mafic granulites collected from the Qingshuiquan area in the eastern section of the EKOB. These rocks record similar P–T paths, which are characterized by a peak stage within suprasolidus and high‐pressure (HP) granulite facies conditions (750–832°C and 10.1–12.0 kbar), followed by an initial decompression and cooling stage to subsolidus conditions (600–748°C and 6.5–8.6 kbar), and then a stage of further retrogression under greenschist facies conditions. The protoliths to these granulites are of volcanic and sedimentary origin and suggested to be a component of the continental basement unit. Metamorphic P–T paths indicate that these rocks experienced peak metamorphism at a depth of ~40 km, then cooling and uplift to a depth of ~25 km, and eventually experienced low‐grade retrogression at shallow crustal levels. Cathodoluminescence images and compositional data demonstrate that the zircons in these rocks are of metamorphic origin and they crystallized at or near peak conditions. SIMS U–Pb dating of representative zircon grains yield concordant metamorphic ages of c. 490–520 Ma, with a peak value of 505 Ma on the probability density curve. These ages are similar to other 480–530 Ma ages typically retrieved from EKOB granulites and associated rocks, and are markedly older than the 400–450 Ma ages retrieved from eclogites and their host rocks. The HP granulites and eclogites of the EKOB do not show overprinting relationships. Such asynchronous characteristics imply that the two rock types formed in distinct tectonic settings and at different stages of a protracted subduction–collision process. The studied granulites are suggested to have formed in the root of a continental arc during a stage of Proto‐Tethys Ocean subduction. The formation of the eclogites could be attributed to subsequent deep continental subduction.
Efficacy and safety of the combination of oral tranexamic acid and intense pulsed light versus oral tranexamic acid alone in the treatment of refractory Riehl's melanosis: A prospective, comparative study
Authors: Xu Zhongyi , Wang Chen , Xing Xiaoxue , Zhang Chengfeng , Xiang Leihong Flora 
Published: March 2024

AbstractBackgroundThere is no standardized and effective treatment modality for Riehl's melanosis.AimsTo compare the efficacy and safety of oral tranexamic acid (TXA) combined with intense pulsed light (IPL) versus TXA alone in the treatment of refractory Riehl's melanosis.MethodsA prospective study of 28 subjects with refractory Riehl's melanosis and Fitzpatrick Skin Types III or IV was conducted. All subjects received oral TXA 500 mg daily and 11 of them were treated in combination with monthly IPL therapy for 6 months. The primary outcome measure was mean melanin index (MI), erythema index (EI) and acquired dermal macular hyperpigmentation area and severity index (DPASI). The Physician Global Assessment (PGA) and patient satisfaction scale were documented.ResultsAfter treatment, DPASI, mean MI, and EI were significantly reduced in both groups. The group treated with combination therapy showed better improvement according to MI (p = 0.0032) and DPASI (p = 0.00468). PGA and patient satisfaction scale showed superior efficacy in the combination group. No significant difference was observed in treatment‐related side effects.ConclusionThe combination of oral TXA and IPL proves to be a safe and satisfactory treatment strategy for refractory Riehl's melanosis.
The effectiveness of cervical rehabilitation interventions for pain in adults with myogenic temporomandibular disorders: A systematic review and meta‐analysis
Authors: Bednarczyk Victoria , Proulx François , Paez Arsenio 
Published: March 2024

AbstractObjectiveLittle evidence exists for the most effective conservative treatment approach for adults with myogenic temporomandibular disorders (MTMD). We aim to assess the effectiveness of cervical rehabilitation interventions on pain intensity and sensitivity in adults with MTMD compared to comparison intervention such as placebo, sham treatment, education or no intervention.MethodsFor this systematic review and meta‐analysis, we searched PubMed, EMBASE, Medline, PEDro databases, forward and backward citations and grey literature studies through PROSPERO, clinical trials and data registries without language or date restrictions between inception and 1 December 2021. We selected randomised controlled trials (RCTs) based on adult populations with MTMD who had a cervical rehabilitation intervention which was defined as any conservative intervention targeting the anatomical structures of the cervical spine. The primary outcome measures for pain were self‐reported pain intensity and pain sensitivity through the pressure pain threshold (PPT) of the masseter and temporalis muscles. Secondary outcome measures of maximal mouth opening (on MMO) were included. Included studies were assessed for bias with the Cochrane risk of bias tool for randomised trials. Evidence from RCTs was synthesised to determine treatment effect size as differences between standardised mean difference (SMD) for changes in pain intensity, PPT and MMO comparing adults with MTMD who were treated with cervical rehabilitation interventions compared to a control group. This study is registered on Prospero, number CRD 42021289299.ResultsOur general search yielded 2647 studies where seven RCTs met eligibility criteria with low to some concerns in their risk of bias. Pain intensity (five studies, n = 223, SMD −0.98, 95% CI −1.67 to −0.28, I2 = 79%), PPT of the masseter muscle (six studies, n = 395, SMD 0.64, 95% CI 0.43 to 0.86, I2 = 90%) and the temporalis muscles (five studies, n = 295, SMD 0.76, 95% CI 0.07 to 1.45, I2 = 84%) showed large treatment effect estimates favouring cervical rehabilitation interventions compared to no treatment, sham cervical treatment, patient education or non‐cervical neuromuscular techniques. Compared to control interventions, one type of cervical rehabilitation intervention, cervical manual therapy alone or in combination with a neck exercise program was associated with statistically significant, large treatment effect estimates on pain intensity (four studies, n = 203, SMD −1.52, 95% CI −2.50 to −0.55).ConclusionsThis review found that in the short‐term, cervical rehabilitation interventions especially upper cervical MT alone or in combination with a neck exercise program are effective in improving multiple pain outcomes in adults with MTMD. However, further research is needed to measure the long‐term effects of this type of intervention.
Variability in spectral absorption within cryptophyte phycobiliprotein types
Authors: Merritt Kristiaän A. , Richardson Tammi L. 
Published: March 2024

AbstractCryptophytes are known to vary widely in coloration among species. These differences in color arise primarily from the presence of phycobiliprotein accessory pigments. There are nine defined cryptophyte phycobiliprotein (Cr‐PBP) types, named for their wavelength of maximal absorbance. Because Cr‐PBP type has traditionally been regarded as a categorical trait, there is a paucity of information about how spectral absorption characteristics of Cr‐PBPs vary among species. We investigated variability in primary and secondary peak absorbance wavelengths and full width at half max (FWHM) values of spectra of Cr‐PBPs extracted from 75 cryptophyte strains (55 species) grown under full spectrum irradiance. We show that there may be substantial differences in spectral shapes within Cr‐PBP types, with Cr‐Phycoerythrin (Cr‐PE) 545 showing the greatest variability with two, possibly three, subtypes, while Cr‐PE 566 spectra were the least variable, with only ±1 nm of variance around the mean absorbance maximum of 565 nm. We provide additional criteria for classification in cases where the wavelength of maximum absorbance alone is not definitive. Variations in spectral characteristics among strains containing the same presumed Cr‐PBP type may indicate differing chromophore composition and/or the presence of more than one Cr‐PBP in a single cryptophyte species.
Phylogenomics of Puya (Bromeliaceae): Evolution in the Andean slopes and sky island ecosystems
Authors: Aguirre‐Santoro Julián , Zuluaga Alejandro , Stonesmyth Emma , Betancur Julio , Jabaily Rachel S. 
Published: March 2024

AbstractPhylogenomics enhances our understanding of plant radiations in the biodiverse Andes. Our study focuses on Puya, primarily Andean and a part of the Bromeliaceae family. Using a phylogenomic framework based on the Angiosperms353 probe set for 80 species, we explored Puya′s phenotypic evolution and biogeography. Divergence time analyses and ancestral area estimations suggested that Puya originated in Central Coastal Chile around 9 million years ago (Ma). Subsequently, it dispersed to the dry valleys of the Central Andes and Puna regions between 5–8 Ma, leading to the emergence of major lineages. Key events in the last 2–4 million years include the recolonization of Chilean lowlands and dispersal to the northern Andes via Peru's Jalcas, facilitating passage through the Huancabamba depression. This event gave rise to the high‐elevation Northern Andes clade. Using phylogenetic comparative methods, we tested the hypothesis that adaptation to the Andes' island‐like high‐elevation ecosystems was facilitated by unique leaf and floral traits, life history, and inflorescence morphology. Our findings suggest correlations between inflorescence axis compression, protective bract overlap, and high‐elevation living, potentially preventing reproductive structure freezing. Semelparity evolved exclusively at high elevations, although its precise adaptive value remains uncertain. Our framework offers insights into Andean evolution, highlighting that lineages adapted to life in dry ecosystems can easily transition to high‐elevation biomes. It also underscores how the island‐like nature of high‐elevation ecosystems influences phenotypic evolution rates. Moreover, it opens avenues to explore genetic mechanisms underlying adaptation to extreme mountain conditions.
Ecological indicator values of understorey plants perform poorly to infer forest microclimate temperature
Authors: Gril Eva , Spicher Fabien , Vanderpoorten Alain , Vital Germain , Brasseur Boris , Gallet‐Moron Emilie , Le Roux Vincent , Decocq Guillaume , Lenoir Jonathan , Marrec Ronan 
Published: March 2024

AbstractQuestionEcological indicator values (EIVs) reflect species‘ optimal conditions on an environmental gradient, such as temperature. Averaged over a community, they are used to quantify thermophilization stemming from climate change, i.e. the reshuffling of communities toward more warm‐adapted species. In forests, understorey plant communities do not keep up with global warming and accumulate a climatic debt. Although the causes are still debated, this thermal lag may be partly explained by forest microclimate buffering. For the first time, we test whether community means of EIVs are able to capture microclimate (here, under forest canopies) temperature across, or also within forests.Location157 forest plots across three French deciduous forests covering a large macroclimatic gradient.MethodsTo assess whether EIVs can be used to infer the mean and range of microclimate temperature in forests, we measured understorey air temperature for ca. 1 year (10 months) with sensors located 1 m above the ground. We surveyed bryophytes and vascular plants within 400‐m2 plots, and computed floristic temperature from ordinal‐scale EIVs (Ellenberg, Julve) and degree‐scale EIVs (ClimPlant, Bryophytes of Europe Traits) for both temperature and continentality, i.e. temperature annual range. Finally, we fitted linear models to assess whether EIVs could explain the mean and range of microclimate temperature in forests.ResultsVascular plant and bryophyte communities successfully reflected differences in mean annual temperatures across forests but largely failed to do so for microclimate variation within forests. Bryophytes did not perform better than vascular plants to infer microclimate conditions. The annual range of microclimate temperatures was poorly associated with ordinal‐scale EIVs for continentality but was positively correlated with degree‐scale EIVs for annual range within lowland forests, especially for vascular plant communities.ConclusionOverall, the capabilities of EIVs to infer microclimate was inconsistent. Refined EIVs for temperature are needed to capture forest microclimates experienced by understorey species.