bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffuse peritoneal liposarcoma—Report of one case
Authors: Colizza S. , Di Maurizio P. , Bracci F. , Bigotti A. , Crisci E. 
Published: February 2007

AbstractA rare case of diffuse peritoneal liposarcoma is reported. The patient, a man aged 45, was admitted with ascites; laboratory and instrumental studies were all negative. Ascites was unresponsive to conservative treatment, so an explorative laparotomy was planned. Parietal and visceral peritoneum showed numerous gelatinous gray‐yellow nodules. Diagnosis was only histologic.
Combination chemoimmunotherapy with FAC‐BCG for metastatic breast cancer: The impact of CMF maintenance chemotherapy
Authors: Hortobagyi G. N. , Blumenschein G. R. , Buzdar A. U. , Yap H. Y. , Schell F. C. , Barnes B. C. , Burgess M. A. 
Published: February 2007

AbstractIn an attempt to prolong the durations of remission and survival of patients with advanced breast cancer treated with the FAC‐BCG protocol, we modified the CMF maintenance combination by increasing the dose of all three drugs and administering them intravenously. Eighty‐five evaluable patients treated with this new regimen were compared with a recent historical control group of 105 evaluable patients treated with FACBCG and a lower‐dose, oral CMF maintenance program. The overall (70% and 76%) and complete (16% and 19%) response rates were identical in these two groups. The median times to progression for all patients entered were similar too (13 months for both groups). The durations of response were 17 months (PO‐CMF) and 14 months (IV‐CMF), not significantly different (P=.16). The durations of survival of the two treated groups were also very similar. After the administration of intensive FAC induction therapy, a high‐dose, intravenous CMF maintenance program appears no better than a lowdose oral regimen. Other drug combinations consisting entirely of drugs not used in the induction regimen might be better choices for maintenance treatment.
Transfemoral hepatic artery infusion for metastatic carcinoma
Authors: Helsper James T. , Lance J. Stanley , Hall Thomas C. 
Published: February 2007

AbstractA total of 86 patients with primary or metastatic cancer in the liver have had their hepatic artery infused with chemotherapeutic agents via a femoral artery catheter placement. A high volume technic was used with various chemotherapeutic agents, mostly 5‐FU. Results in colon primaries averaged 11.7 months as survivals in the responders; 29 of 45 patients in this group responded. Various other primaries were treated, and the results are given.
Effectiveness of a community program to promote early breast cancer detection
Authors: Boyle Michele , Michalek Arthur , Bersani Gayle , Nemoto Takuma , Mettlin Curtis 
Published: February 2007

AbstractThere are no known means of preventing breast cancer, and efforts to control the disease must be directed toward early detection and improved treatment. To assist in achieving this, we developd a two‐tier educational program aimed at educating women regarding breast cancer facts and the proper performance of breast self‐examination (BSE). Educational efforts are first directed at nurses who are then encouraged to transmit this information to women and their partners in the community. The program combines a lecture and demonstration with more informal small group discussions that allow for individual demonstrations of the technique of BSE. Follow‐up of both nurse and lay participants by means of telephone interviews has shown that women can be motivated to practice BSE, and be made aware of proper techniques.
The ABO(H) cell surface antigens in carcinoma and benign lesions of the breast
Authors: Shull James H. , Javadpour Nasser , Soares Thomas , Demoss Ernest V. 
Published: February 2007

AbstractThe ABO(H) cell surface antigens of 13 breast carcinomas and 17 benign breast lesions were tested with a specific red cell adherence assay (SRCA). All 13 breat carcinomas, including 2 lobular carcinomas in situ and 1 noninfiltrating ductal carcinoma, had lost their ABO(H) surface antigens. Fourteen of 17 benign breast lesions had retained their ABO(H) surface antigens. The benign lesions losing their antigens were 1 case each of atypical intraductal hyperplasia, sclerosing adenosis, and intraductal papilloma. SRCA may be a predictor of which benign breast lesions are in fact premalignant.
Endocrine ablation in breast cancer patients who have failed cytotoxic therapy
Authors: Ferrara John J. , Reiches Nancy A. , Minton John Peter 
Published: February 2007

AbstractBetween 1972 and 1979, forty‐six women underwent endocrine ablative surgery, having failed combinations of chemotherapy, radiation, and surgery (including oophorectomy). All had clinically measurable disease; nearly half were afflicted with bone pain. Each was judged to be a candidate for the procedure by estrogen receptor studies (52%), response to L‐dopa (39%), or response to prior oophorectomy (8%). All were followed to their death or to the present, with a minimum of 12 months for those alive. Thirty‐one (67%) were improved, and disease was arrested in five (11%) for a median time of 13.5 months. There was no difference in response rates or intervals between estrogen receptor‐positive and L‐dopa‐positive groups. Response was not correlated with disease‐free interval or menopausal status. Best results were achieved in those with metastases confined to an organ system, particularly the skeletal complex. The procedure is withheld in those with brain metastases. Postablative chemotherapy appeared to prolong the control interval, though numbers are small. The low morbidity and mortality (one death) of midline adrenaloophorectomy combined with the high incidence of recapture of disease leads us to recommend this procedure in appropriately selected patients who have previously failed other therapeutic modalities.
Ethmoid sinus adenocarcinoma metastatic to breast
Authors: Vizel Monique , Oster Martin W. 
Published: February 2007

AbstractA young woman developed metastases to both breasts from an ethmoid sinus adenocarcinoma diagnosed 2 1/2 years earlier. Despite surgical excision of the breast metastases, postoperative radiotherapy to both breasts, and intensive chemotherapy, her breast metastases recurred in association with rapid progression of the disease in general. She died 1 year after the initial diagnosis of breast metastases. This case is the eighth report of a malignancy arising in the head and neck that metastasized to the breasts. The relevant literature is reviewed.
Primary gastric lymphoma following renal transplantation
Authors: McTamaney J. Paul , Nefeld James P. , Mendezpicon Gerardo , Lee H. M. 
Published: February 2007

AbstractA renal allograft recipient was diagnosed as having a primary gastric lymphoma 11 years following transplant. Pathology showed a large cell diffuse (histiocytic) lymphoma with lymph node metastases. Pulmonary metastases developed despite curative resection and adjuvant radiation therapy. An aggressive approach to the evaluation of abdominal symptoms following transplantation is indicated to attempt early diagnosis of gastrointestinal malignancies and to allow prompt treatment.
The role of cytogenetic tests in detection and prevention of cancer
Authors: Bishun N. P. 
Published: February 2007

AbstractAlthough simplified and improved techniques have increased at a fast rate in recent years, a great number of compounds released into our environment still remain untested. It has been estimated that between 80‐90% of human cancer is a result of exposure to such compounds, and if by the application of short‐term mutagenic tests, the use of many of these compounds can be severely restricted, an enormous impact can be made on the solution of human health problems.Batteries of mutagenic tests have established an empirical relationship between mutagenisis and carcinogenisis, and, in view of the cost in terms of time and money, short‐term tests are playing an important role in first detecting, and second, eliminating potential hazards in our environment.The use of bacteria and other unicellular organisms in these assay systems has met with much criticism; due to the fact that the DNA materials affected do not directly relate to that of man. However, in conjunction with other tests, utilizing human and other mammalian cells, firm conclusions can be drawn regarding the potential hazards of certain chemicals.Recent advances in cytogenetic tests (e.g., banding chromosomes and sister chromatid exchange) have improved the sensitivity of chromosomal tests and, in so doing, have rendered them more useful in the selecting out process that can reduce substantially the mutagenic and carcinogenic hazards caused by chemicals and other deleterious agents in the environment.
Biliary cystadenocarcinoma: Report of a case presenting with osseous metastasis and a review of the literature
Authors: Berjian Richard A. , Nime Freda , Douglass Harold O. , Nava Hector 
Published: February 2007

AbstractBiliary cystadenocarcinomais a rare malignancy, and osseous metastasis resulting from this tumor has been recorded in only one of the 19 documented cases in the literature. The case report of this 59‐year‐old male is unusual in that the patient's initial clinical manifestations of the disease were that of osseous metastases, while the primary tumor eluded discovery for greater than 1 year. Although this is the first documented case in which radiation and chemotherapy were used to control the disease, the use of these agents may have contributed to the delay in establishing the primary site of the tumor. The clinical and pathologic features of this and the previously reported cases are reviewed witb an emphasis on the newer diagnostic modalities being used in more recent cases to establish the diagnosis for this tumor.
Enumeration of lymphocytes and their subpopulations identified by bacterial adherence in blood smears of patients with breast tumors
Authors: Felix Edward , Katz Sherry , Teodorescu A. , Teodorescu M. 
Published: February 2007

AbstractPeripheral blood lymphocyte counts were determined in 57 breast clinic patients. These patients were grouped into four clinical/pathological groups: 18 had benign breast disease, 13 had a history of breast cancer but were free of disease at the time of the study, 7 had a history of breast cancer and were free of disease at the time of the study but were on adjuvant chemotherapy, and 19 had active metastatic breast cancer. Two parameters were investigated in a double blind study: 1) the absolute lymphocyte counts and 2) the percentages of lymphocytes that bound different bacteria as markers of lymphocyte subpopulations in conventionally stained blood smears. A significant reduction in mean lymphocyte counts was demonstrated in patients with advanced disesase. A significant increase in these counts was found in patients who were free of disease following surgical treatment alone. The T1 T2 cells (our denomination), the subpopulation of cells responsible for specific killing in vitro and for suppression of natural cytotoxic cells, was significantly reduced in patients with advanced disease under treatment. The T/B cell ratio in all groups was the same and within normal range. These observations suggest that the observed decrease in the total lymphocytes is due not only to an overall decrease in all classes of lymphocytes but especially in those responsible for specific cell‐mediated reactions. They also show that bacteria can be used as reliable reagents for the identification of lymphocyte subpopulations in blood smears.
Adjuvant chemotherapy of soft‐part sarcomas with ALOMAD (S4)
Authors: Sordillo Peter P. , Magill Gordon B. , Shiu Man H. , Lesser Martin , Hajdu Steven I. , Golbey Robert B. 
Published: February 2007

AbstractSixty‐four adult patients with soft‐tissue sarcomas received adjuvant chemotherapy with a six‐drug combination regimen after surgery. Seventy percent remain free of disease with a median follow‐up of 50 months. Only seven patients have died of their disease, all within the first 24 months after surgery. Most patients experienced severe nausea and vomiting secondary to the actinomycin D and dacarbazine parts of the protocol, and three patients experienced frank Adriamycin cardiomyopathy. Toxicity from this combination was otherwise mild. The 58% recurrence rate of 12 patients who discontinued therapy early because of nausea was significantly greater than the 23% rate for those who completed or relapsed on therapy (P = 0.01). Adjuvant chemotherapy should be considered after surgery for patients with soft‐part sarcomas, especially those with high‐grade tumors that have a considerable risk of recurrence.
Steroid receptors in a group of Brazilian breast cancer patients
Authors: Brentani M. M. , Nagai M. A. , Fujiyama C. T. , Góes J. C. S. 
Published: February 2007

AbstractTwo hundred and forty‐two primary breast cancers were assayed for estrogen receptors (ER). Of these, 202 were analyzed for progesterone receptors (PR) and 155 for glucocorticoid receptors (GR). ER was positive in 58% of the specimens; PR and GR were positive in 57%. A positive association was found between ER but not PR or GR frequency and age.Frequency of ER, PR, and GR positivity was approximately the same in premenopausal and postmenopausal women but ER content was much higher in postmenopausal women. About 70% of ER+ patients were also PR+ and GR+. Both frequency of PR positivity as well as average concentration, and frequency of GR positivity as well as average concentration were positively correlated with ER.
Aspergillus peritonitis complicating perforated appendicitis in adult acute leukemia
Authors: Weingrad Daniel N. , Knapper William H. , Cold Jonathan , Mertelsmann Roland 
Published: February 2007

AbstractA 38‐year‐old male with terminal transferase positive acute lymphoblastic leukemia experienced fever, polymicrobial bacteremia, gastrointestinal bleeding, abdominal pain during induction therapy, and remission. Cecal perforation, Aspergillus peritonitis, and subsequent diseminated aspergillosis were successfully managed with colon resection, drainage, and antibiotic and anti‐fungal therapy. Serologic tests for antibody to Aspergillus were repeatedly negative.
Renal pseudotumour following treatment of wilms' tumour
Authors: Verstandig A. G. , Gordon R. L. , Abu‐Dalu K. , Okon E. 
Published: February 2007

AbstractA 9 1/2‐year‐oId boy was found to have a mass occupying the lower pole of his left kidney, six years after his right kidney had been removed because of a Wilms' tumour. Investigation of the mass included angiography which demonstrated a mass with pathological arteries. Open biopsy of the mass revealed histological changes of nonspecific nephritis. It is probable that this nephritis was a result of radiation damage potentiated by concurrent treatment with actinomycin D, which he had received six years ago.
Cell surface antigen ‐a study in bladder tumours
Authors: Kulkarni Jagdeesh N. , Kamat Murali R. , Gangal S. C. , Talwalkar G. V. 
Published: February 2007

AbstractThirty bladder tumours of various stages and grades were examined for the presence of A.B.O. (H) cell surface antigen using specific red cell adherence (SCRA) technique. Ten patients with stage A disease and low grade tumour (grade I) retained the antigens, whereas all patients with high stage disease (B,C,D) and high grade tumours showed absence of antigen. When these data were correlated with recurrence pattern and metastasis or invasion rate, patients who did not show the antigen at the initial visit developed metastases and had poor prognoses. The patient who had expressed the antigen by positive SCRA had fewer recurrences and a longer tumour‐free interval Hence if SCRA is done in all bladder tumours at the initial visit and at subsequent follow‐up, it can be used as a biological marker.
Breast carcinoma: Expected results with prevailing therapy
Authors: Haid Max , Zuckerman Leon 
Published: February 2007

AbstractComputer‐stored tumor registry data were scanned to produce the set of patients whose breast carcinoma was either diagnosed or first treated at Evanston Hospital between the years 1973 and 1977, inclusive. Of 560 evaluable patients, 184 were less than or equal to age 50 (LE 50). and 376 were greater than age 50 (GT 50). Comparisons of projected survival show that the survival of all patients is 81% at 5 years and 72% at 7 years. The survival of patients LE 50 is nearly identical to that of the GT 50 age group. Survival of Stage III GT 50 patients, however, is better than Stage III LE 50 (P < 0.001). Comparison with earlier studies shows an historical trend toward better 5‐year survival. Data were generated in this study which allow prediction of pronosis based upon age and stage at diagnosis.
Lack of association between weight and oestrogen receptors in women with breast cancer
Authors: Mason Barbara , Holdaway I. M. , Yee Lye , Kay R. G. 
Published: February 2007

AbstractEvidence for a relationship between body weight and tumour oestrogen receptor (ER) level has been sought in women with newly diagnosed breast cancer. There was no significant correlation between body weight and tumour ER concentration, either over the whole range of observed weight or when considering groups above or below a weight of 68 kg. Similarly, when women were subgrouped by prognostic variables such as nodal status, tumour size, or menopausal status, there was no significant relationship between ER level and body weight. These data suggests that observations linking breast cancer risk with increasing body weight cannot be explained by variations in ER level.
Gastric duplication associated with adenomyoma
Authors: Floros Demosthenes , Dosios Theodosios , Gourtsoyiannis Nicholas , Vyssoulis Charalambos 
Published: February 2007

AbstractA case of gastric duplication associated with adenomyoma including ectopic pancreatic tissue in an adult patient is reported. The histologic features, diagnostic criteria, and pathogenesis are briefly discussed.
The effects of urea treatment in combination with curettage in extensive lip cancers
Authors: Danopoulos E. D. , Danopoulou I. E. , Besbeas S. , Ramantanis C. 
Published: February 2007

AbstractThirty cases of lip cancer in 28 patients, 23 of which were extensive or very extensive, were treated with local urea injections in combination with curettage. Out of the 30 cases there were 26 squamous cell carcinomas, three basal cell carcinomas extending to the mucosa from the skin of the lips, and one adenocarcinoma of the mucosa of the interior surface of the upper lip. This treatment was effective in all our patients. Recurrences appeared in four patients. These were easily treated in three out of the four patients who returned for treatment, by the same method. In three cases metastases appeared in the lymphnodes of the neck, which were surgically treated.
The role of chemotherapy as an adjuvant to surgery in the initial treatment of primary soft tissue sarcomas in adults
Authors: Das Gupta Tapas K. , Patel Minu K. , Chaudhuri Prabir K. , Briele Henry A. 
Published: February 2007

AbstractA prospective study was carried out to determine the results of chemotherapy as an adjuvant to surgery in the initial treatment of adult primary soft tissue sarcomas. The results were compared with those in a group of patients with similar histologic types of primary sarcoma treated by surgery alone. The chemotherapy regimen consisted of adriamycin, 60 mg/m2 intravenously on Day 1, and DTIC, 250 mg/m2 on Days 1 through 5. The cycle was repeated every 22 days. The total dose of adriamycin was 500 mg/m2; the DTIC was continued for 1 year. The adjuvant chemotherapy group consisted of 113 patients (group one) and the concurrent surgical resection group consisted of 144 patients (group two). In group one, 53 tumors were T1 and 60 tumors were T2; 67 of the tumors were grade 3 and 46 were grade 4. In group two, 65 had T1 and 79 had T2 tumors; 82 tumors were grade 3 and 62 were grade 4. The anatomic location and histologic types were similar in both groups. Seventy‐seven (77%) of the 113 patients in group one lived disease free for 2 years, compared with 59% of the 144 patients treated by resection alone. Of the patients eligible for 5‐year survival analysis, 74% were disease free in the adjuvant chemotherapy group, compared to 50% in the surgical group. The incidence of local recurrence was about the same in both groups. From a histologic standpoint, malignant fibrous histiocytomas and myogenic sarcomas appeared to benefit most with use of the use of the two‐drug regimen used here, and the least favorable response was in liposarcomas and fibro‐sarcomas. In other histologic types, the role of adjuvant chemotherapy needs further clarification.
Comparison of the techniques used for monitoring humoral immunity in cancer patients
Authors: Renk Clifford M. , Gupta Rishab K. , Irie Reiko F. , Morton Donald L. 
Published: February 2007

AbstractThe humoral immune response to tumor‐associated antigens (TAA) in cancer patients undergoing immunotherapy can vary considerably. This variability is inherent from patient to patient and is also dependent on the type of assay used to measure patient antibody response to tumors. In this investigation four serological techniques, complement‐dependent antibody‐mediated cytotoxicity, immune adherence, complement fixation, and indirect membrane immunofluorescence, were used to assess the humoral immune response in melanoma patients receiving specific immunization with cultured allogeneic melanoma cell vaccine.Two different patterns of antibody response were elicited. One was directed against TAA and oncofetal antigens (OFA) and the other was against HLA antigens. The sensitivity and reactivity varied among the different techniques suggesting that one test or technique may not be sufficient to evaluate critically a patient's response to immunotherapy.
Mandible preservation in the treatment of cancer of the floor of the mouth
Authors: Beecroft Wayne A. , Sako Kumao , Razack Mohamed S. , Shedd Donald P. 
Published: February 2007

AbstractA segmental anterior mandibulectomy causes severe functional disability and cosmetic problems. Many methods of reconstruction have been used but none of these procedures provides the ideal solution. There has been increasing interest in the possibility of preserving a portion of the anterior mandibular arch and still carrying out an adequate surgical excision to control the primary tumor. Over a 15‐year period, 251 patients with cancer of the floor of mouth were seen and treated at Roswell Park Memorial Institute. Of this group, 34 patients underwent a marginal mandibular resection as part of their curative surgical treatment. The complication rate was acceptable and the 5‐year determinate survival rate was 84%. The local control rate was excellent with only one patient developing an intraoral recurrence which was successfully treated with radiation. It is felt that these data support the theory that conservative mandibular surgery can be carried out in selected cases without jeopardizing the concept of a good cancer operation.