bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the understanding of the core of general personality disorder factor: g-PD and its relation to hostile attributions
Authors: Zajenkowska Anna , Nowakowska Iwona , Cieciuch Jan , Gawęda Łukasz , Rogoza Radosław , Pinkham Amy , Czajkowska-Łukasiewicz Katarzyna 
Published: March 2024

Abstract
There is a general consensus that personality disorders (PDs) share a general factor (g-PD) overlapping with the general factor of psychopathology (p-factor). The general psychopathology factor is related to many social dysfunctions, but its nature still remains to some extent ambiguous. We posit that hostile attributions may be explanatory for the factor common for all PDs, i.e., interpersonal problems and difficulty in building long-lasting and satisfying relationships of all kinds. Thus, the main objective of the current project was to expand the existing knowledge about underlying factors of g-PD with regard to hostile attributions. We performed a cross-sectional study on a representative, community sample of Poles (N = 1031). Our hypotheses were primarily confirmed as hostile attributions predicted p-factor. However, the relation was positive only for hostile attributions related to ambiguous situations involving relational harm and physical harm done by female authorities and negative in case of hostile attributions in situations involving physical harm done by peers. Additionally, paranoia-like thoughts strongly related to hostile attributions and independently predicted g-PD. The results contribute to the current discussion on the nature of the g-PD, confirm that hostile attributions and paranoia are a crucial aspect of personality pathology, and indicate the importance of working on these cognitions in the course of therapeutic work.
Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife
Authors: Stephenson Mallory , Barr Peter , Thomas Nathaniel , Cooke Megan , Latvala Antti , Rose Richard J. , Kaprio Jaakko , Dick Danielle , Salvatore Jessica E. 
Published: March 2024

Abstract
We took a multilevel developmental contextual approach and characterized trajectories of alcohol misuse from adolescence through early midlife, examined genetic and environmental contributions to individual differences in those trajectories, and identified adolescent and young adult factors associated with change in alcohol misuse. Data were from two longitudinal population-based studies. FinnTwin16 is a study of Finnish twins assessed at 16, 17, 18, 25, and 35 years (N = 5659; 52% female; 32% monozygotic). The National Longitudinal Study of Adolescent to Adult Health (Add Health) is a study of adolescents from the United States, who were assessed at five time points from 1994 to 2018 (N = 18026; 50% female; 64% White, 21% Black, 4% Native American, 7% Asian, 9% Other race/ethnicity). Alcohol misuse was measured as frequency of intoxication in FinnTwin16 and frequency of binge drinking in Add Health. In both samples, trajectories of alcohol misuse were best described by a quadratic growth curve: Alcohol misuse increased across adolescence, peaked in young adulthood, and declined into early midlife. Individual differences in these trajectories were primarily explained by environmental factors. Several adolescent and young adult correlates were related to the course of alcohol misuse, including other substance use, physical and mental health, and parenthood.
Public Reason, Bioethics, and Public Policy: A Seductive Delusion or Ambitious Aspiration?
Authors: Fleck Leonard M. 
Published: March 2024

Abstract
Can Rawlsian public reason sufficiently justify public policies that regulate or restrain controversial medical and technological interventions in bioethics (and the broader social world), such as abortion, physician aid-in-dying, CRISPER-cas9 gene editing of embryos, surrogate mothers, pre-implantation genetic diagnosis of eight-cell embryos, and so on? The first part of this essay briefly explicates the central concepts that define Rawlsian political liberalism. The latter half of this essay then demonstrates how a commitment to Rawlsian public reason can ameliorate (not completely resolve) many of the policy disagreements related to bioethically controversial medical interventions today. The goal of public reason is to reduce the size of the disagreement by eliminating features of the disagreement that violate the norms of public reason. The norms of public reason are those norms that are politically necessary to preserve the liberal, pluralistic, democratic character of this society. What remains is reasonable disagreement to be addressed through normal democratic deliberative processes. Specific issues addressed from a public reason perspective include personal responsibility for excessive health costs, the utility of a metaphysical definition of death for organ transplantation, and the moral status of excess embryos generated through IVF and/or their use in medical research.
Six elements test vs D-KEFS: what does “Ecological Validity” tell us?
Authors: Suchy Yana , Gereau Mora Michelle , Brothers Stacey Lipio , DesRuisseaux Libby A. 
Published: March 2024

AbstractObjective:Extensive research shows that tests of executive functioning (EF) predict instrumental activities of daily living (IADLs) but are nevertheless often criticized for having poor ecological validity. The Modified Six Elements Test (MSET) is a pencil-and-paper test that was developed to mimic the demands of daily life, with the assumption that this would result in a more ecologically valid test. Although the MSET has been extensively validated in its ability to capture cognitive deficits in various populations, support for its ability to predict functioning in daily life is mixed. This study aimed to examine the MSET’s ability to predict IADLs assessed via three different modalities relative to traditional EF measures.Method:Participants (93 adults aged 60 – 85) completed the MSET, traditional measures of EF (Delis-Kaplan Executive Function System; D-KEFS), and self-reported and performance-based IADLs in the lab. Participants then completed three weeks of IADL tasks at home, using the Daily Assessment of Independent Living and Executive Skills (DAILIES) protocol.Results:The MSET predicted only IADLs completed at home, while the D-KEFS predicted IADLs across all three modalities. Further, the D-KEFS predicted home-based IADLs beyond the MSET when pitted against each other, whereas the MSET did not contribute beyond the D-KEFS.Conclusions:Traditional EF tests (D-KEFS) appear to be superior to the MSET in predicting IADLs in community-dwelling older adults. The present results argue against replacing traditional measures with the MSET when addressing functional independence of generally high-functioning and cognitive healthy older adult patients.
Time series analysis of GSS bonds
Authors: Dey D. 
Published: March 2024

Abstract
The market for green bonds, and environmentally aligned investment solutions, is increasing. As of 2022, the market of green bonds exceeded USD 2 trillion in issuance, with India, for example, having issued its first-ever sovereign green bonds totally R80bn (c.USD1bn) in January 2023. This paper lays the foundation for future papers and summarises the initial stages of our analysis, where we try to replicate the S&P Green Bond Index (i.e. this is a time series problem) over a period using non-traditional techniques. The models we use include neural networks such as CNNs, LSTMs and GRUs. We extend our analysis and use an open-source decision tree model called XGBoost. For the purposes of this paper, we use 1 day’s prior index information to predict today’s value and repeat this over a period of time. We ignore for example stationarity considerations and extending the input window/output horizon in our analysis, as these will be discussed in future papers. The paper explains the methodology used in our analysis, gives details of general underlying background information to the architecture models (CNNs, LSTMs, GRUs and XGBoost), as well as background to regularisation techniques specifically L2 regularisation, loss curves and hyperparameter optimisation, in particular, the open-source library Optuna.
Three approaches to assessing dietary quality in Mexican adolescents from 2006 to 2018 with data from national health and nutrition surveys
Authors: Gaona-Pineda Elsa Berenice , López-Olmedo Nancy , Moreno-Macías Hortensia , Shamah-Levy Teresa 
Published: March 2024

Abstract

Objective:
To assess trends in the dietary quality of Mexican adolescents from 2006 to 2018, both overall and by sociodemographic indicators, using adaptations of the EAT-Lancet Planetary Health (PH) recommendations, optimal intake estimated by the Global Burden of Disease (GBD) and 2015 Mexican Dietary Guidelines (MDG) in nationally representative samples.

Design:
Using dietary data from a semi-quantitative FFQ, dietary quality indexes were constructed as adaptations of three dietary intake recommendations. Trends in adherence to recommendations were evaluated with multivariate quantile regression models with survey year as the main independent variable and adjusted for age, sex, energy intake, dwelling area, geographical region, household assets condition, and student/non-student status. P values and CI were Bonferroni-corrected.

Setting:
Mexico.

Participants:
Non-pregnant or lactating adolescents aged 12–19 years (n 16 520).

Results:
Adherence to the PH index was about 40 %, GBD was nearly 35 % and MDG was about 37 %. The lowest adherences were for added sugars, sugar-sweetened beverages, nuts and seeds, red meats, processed meats, and legumes (<28 %). No 2006–2018 trends in total adherence were found in any index. Nevertheless, negative adherence trends were identified for poultry (β = –2·4), and saturated fats (β = –0·93), and positive for unsaturated oils (β = 1·23), in the PH. In MDG, relevant trends were found for plain water (β = 1·63) and foods rich in fats (β = –1·24).

Conclusions:
Mexican adolescents have demonstrated poor dietary quality by these three approaches. Therefore, this population has a high-risk profile for diet-associated chronic diseases. Further research and appropriate public policies are needed.
Between Faith and Judgement: Kant’s Dual Conception of Moral Certainty
Authors: Di Giulio Sara 
Published: March 2024

AbstractThere are two main meanings in Kant’s concept of moral certainty (moralische Gewissheit, certitudo moralis): first, it applies to the kind of certainty embodied in rational faith in the existence of God and a future life; second, it applies to the conscientiousness (Gewissenhaftigkeit) required of an agent in the practice of moral judgement. Despite the growing attention to Kant’s theory of conscience and his concept of conscientiousness, this article is the first to discuss ‘moral certainty’ as the aim of ‘conscientiousness’ and to highlight the relevance of both notions in regard to moral education and the purposes of Kant’s ethical doctrines of method.
Structure and Tectonic Evolution of the NW Sulu Sea Basin (SE Asia)
Authors: Cadenas Patricia , Ranero César R. 
Published: March 2024

AbstractWe discuss the tectonic structure, seismic stratigraphy and evolution of the NW Sulu Sea using reprocessed 2D reflection profiles. The NW Sulu Sea is located between the Palawan continental shelf and the Cagayan Ridge and represents the northern part of the Sulu Sea, a marginal sea resulting from Paleogene extension and subsequent Neogene contraction due to convergence between the Palawan and the Philippine blocks. The basin consists of six seismo‐stratigraphic units overlying crystalline basement. Syn‐orogenic depocenters contain calibrated Middle Miocene to, possibly, Lower Miocene units, while rift‐related depocenters consist of uncalibrated but tentatively dated Paleogene to Lower Miocene units. Thickness and depth maps of the main units and bounding horizons differentiate the Piedra‐Blanca and the Rasa domains, separated by the NW‐Sulu‐Break major tectonic structure. Fault‐bounded rift‐related depocenters are strongly segmented. We interpret that NW‐SE and NE‐SW trending zones accommodate shape and trend variations of these depocenters. We suggest that these zones may link rift segments, recording different extensional deformation. Miocene thrusting and folding in the Piedra‐Blanca Domain and mudflow with associated gravitational structures in the Rasa Domain influenced the deposition of syn‐orogenic units. Rift structures inherited from rift segmentation may have conditioned the style and distribution of contractional deformation during the subsequent incipient reactivation during contraction. In the context of SE Asia, our results support that the timing of rifting of the NW Sulu Sea overlaps with the opening of the South China Sea and the North Palawan margin, which may indicate a common geodynamic driving force triggering extension.
Multi‐Platform Observations of Severe Typhoon Koinu
Authors: He J. Y. , Chan P. W. , Choy C. W. , Cheung P. , Chan Y. W. , Lam C. C. , He Y. H. , Rong P. , Su H. , Li Z. M. 
Published: March 2024

AbstractSevere Typhoon Koinu passed south of Hong Kong on 8 and 9 October 2023, triggering the issuance of the Increasing Gale or Storm Signal No. 9, the second highest tropical cyclone (TC) warning signal in Hong Kong. Koinu was a difficult case for TC warning service due to its compact size and rather erratic movement over the coastal waters of Guangdong. To monitor Koinu's movement and wind structure, the Hong Kong Observatory utilized various observational platforms, including meteorological aircraft, ocean radar, and synthetic aperture radar on polar orbiting satellites. The paper presents major observations derived from these measurements. The aircraft probe and dropsonde data suggested boundary layer inflow, warm core structure, eyewall updraft, and high turbulence in the eyewall of the typhoon. The weather radar observations indicated the occurrence of a waterspout in the vicinity of the typhoon. Additionally, the study highlights the forecasting performance of the AI‐based Pangu‐Weather model, which could outperform the conventional global numerical weather prediction models in forecasting TC track in the region. The documentation of these observations aims to provide valuable references for weather forecasters and stimulate further research on forecasting this type of tropical cyclone.
Thermal Stability of F‐Rich Phlogopite and K‐Richterite During Partial Melting of Metasomatized Mantle Peridotite With Implications for Deep Earth Volatile Cycles
Authors: Steenstra E. S. , Klaver M. , Berndt J. , Flemetakis S. , Rohrbach A. , Klemme S. 
Published: March 2024

AbstractPhlogopite and K‐richterite constitute important carrier phases for H and F in Earth's lithosphere and mantle. The relative importance depends on their stabilities at high pressure and temperature, which in turn depends on bulk composition. Most previous experimental studies focused on the thermal stability of phlogopite and K‐richterite were conducted using simplified chemical compositions. Here, partial melting experiments on metasomatized and carbonated, OH ± F‐bearing near‐natural peridotite were performed at high pressures (2 and 5 GPa) and temperatures (1,100–1,350°C) to assess the thermal stability of F‐free versus F‐bearing phlogopite and K‐richterite. Experimental results demonstrate that the thermal stability of F‐bearing phlogopite is increased by >55°C/wt.% F, relative to F‐free phlogopite, whereas K‐richterite is absent in all experiments with significant degrees of melting (>2%). The thermal stability of phlogopite containing several wt.% F exceeds continental and oceanic geotherms within the upper 150 km. Fluorine‐rich phlogopite would therefore be stable in virtually all of the continental lithosphere, only to be decomposed during large, regional melting events such as continental break‐up, thereby acting as a major long‐term sink for F and/or H. This could even be the case for the oceanic asthenosphere, depending on the oceanic geotherm of the area of interest.
Deciphering Controls of Pore‐Pressure Evolution on Sediment Bed Erosion by Debris Flows
Authors: Zheng Hongchao , Hu Xinli , Shi Zhenming , Shen Danyi , De Haas Tjalling 
Published: March 2024

AbstractPore‐fluid pressure (PP) plays an important role in bed erosion, but the mechanisms that control PP evolution and the resulting feedbacks on flow dynamics are unclear. Here, we develop a general formulation, allowing quantification of the propensity for PP evolution of saturated and unsaturated bed sediments. We conduct erosion experiments by systematically varying grain composition and water content of beds, for investigating effects of PP evolution on flow erosion. With increasing water content, PP shows a slight rise in deforming beds with drained behavior but significant larger rise in undrained beds. Regardless of bed composition, the erosion rate of beds presents a synchronous change tendency with PP evolution due to the loss in basal friction. PP instigates positive feedback that induces a remarkable gain of flow velocity and momentum on wet beds with undrained behavior. Our results help explain observations of volume growth and long run out of debris flows.
Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective
Authors: Wilson Emma L. , Yu Yizhou , Leal Nuno S. , Woodward James A. , Patikas Nikolaos , Morris Jordan L. , Field Sarah F. , Plumbly William , Paupe Vincent , Chowdhury Suvagata R. , Antrobus Robin , Lindop Georgina E. , Adia Yusuf M. , Loh Samantha H. Y. , Prudent Julien , Martins L. Miguel , Metzakopian Emmanouil 
Published: March 2024

AbstractOrganelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of mitochondria and ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, and cardiac diseases. Although MERCS have been extensively studied, much remains to be explored. To uncover novel regulators of MERCS, we conducted a genome-wide, flow cytometry-based screen using an engineered MERCS reporter cell line. We found 410 genes whose downregulation promotes MERCS and 230 genes whose downregulation decreases MERCS. From these, 29 genes were selected from each population for arrayed screening and 25 were validated from the high population and 13 from the low population. GET4 and BAG6 were highlighted as the top 2 genes that upon suppression increased MERCS from both the pooled and arrayed screens, and these were subjected to further investigation. Multiple microscopy analyses confirmed that loss of GET4 or BAG6 increased MERCS. GET4 and BAG6 were also observed to interact with the known MERCS proteins, inositol 1,4,5-trisphosphate receptors (IP3R) and glucose-regulated protein 75 (GRP75). In addition, we found that loss of GET4 increased mitochondrial calcium uptake upon ER-Ca2+ release and mitochondrial respiration. Finally, we show that loss of GET4 rescues motor ability, improves lifespan and prevents neurodegeneration in a Drosophila model of Alzheimer’s disease (Aβ42Arc). Together, these results suggest that GET4 is involved in decreasing MERCS and that its loss is neuroprotective.
Delivery of a BET protein degrader via a CEACAM6-targeted antibody–drug conjugate inhibits tumour growth in pancreatic cancer models
Authors: Nakazawa Youya , Miyano Masayuki , Tsukamoto Shuntaro , Kogai Hiroyuki , Yamamoto Akihiko , Iso Kentaro , Inoue Satoshi , Yamane Yoshinobu , Yabe Yuki , Umihara Hirotatsu , Taguchi Junichi , Akagi Tsuyoshi , Yamaguchi Atsumi , Koga Minaho , Toshimitsu Kohta , Hirayama Toshifumi , Mukai Yohei , Machinaga Akihito 
Published: March 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all cancers. To improve PDAC therapy, we establish screening systems based on organoid and co-culture technologies and find a payload of antibody–drug conjugate (ADC), a bromodomain and extra-terminal (BET) protein degrader named EBET. We select CEACAM6/CD66c as an ADC target and developed an antibody, #84.7, with minimal reactivity to CEACAM6-expressing normal cells. EBET-conjugated #84.7 (84-EBET) has lethal effects on various PDAC organoids and bystander efficacy on CEACAM6-negative PDAC cells and cancer-associated fibroblasts. In mouse studies, a single injection of 84-EBET induces marked tumor regression in various PDAC-patient-derived xenografts, with a decrease in the inflammatory phenotype of stromal cells and without significant body weight loss. Combination with standard chemotherapy or PD-1 antibody induces more profound and sustained regression without toxicity enhancement. Our preclinical evidence demonstrates potential efficacy by delivering BET protein degrader to PDAC and its microenvironment via CEACAM6-targeted ADC.
Enabling large-scale screening of Barrett’s esophagus using weakly supervised deep learning in histopathology
Authors: Bouzid Kenza , Sharma Harshita , Killcoyne Sarah , Castro Daniel C. , Schwaighofer Anton , Ilse Max , Salvatelli Valentina , Oktay Ozan , Murthy Sumanth , Bordeaux Lucas , Moore Luiza , O’Donovan Maria , Thieme Anja , Nori Aditya , Gehrung Marcel , Alvarez-Valle Javier 
Published: March 2024

AbstractTimely detection of Barrett’s esophagus, the pre-malignant condition of esophageal adenocarcinoma, can improve patient survival rates. The Cytosponge-TFF3 test, a non-endoscopic minimally invasive procedure, has been used for diagnosing intestinal metaplasia in Barrett’s. However, it depends on pathologist’s assessment of two slides stained with H&E and the immunohistochemical biomarker TFF3. This resource-intensive clinical workflow limits large-scale screening in the at-risk population. To improve screening capacity, we propose a deep learning approach for detecting Barrett’s from routinely stained H&E slides. The approach solely relies on diagnostic labels, eliminating the need for expensive localized expert annotations. We train and independently validate our approach on two clinical trial datasets, totaling 1866 patients. We achieve 91.4% and 87.3% AUROCs on discovery and external test datasets for the H&E model, comparable to the TFF3 model. Our proposed semi-automated clinical workflow can reduce pathologists’ workload to 48% without sacrificing diagnostic performance, enabling pathologists to prioritize high risk cases.
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression
Authors: Xu Meng , Ito-Kureha Taku , Kang Hyun-Seo , Chernev Aleksandar , Raj Timsse , Hoefig Kai P. , Hohn Christine , Giesert Florian , Wang Yinhu , Pan Wenliang , Ziętara Natalia , Straub Tobias , Feederle Regina , Daniel Carolin , Adler Barbara , König Julian , Feske Stefan , Tsokos George C. , Wurst Wolfgang , Urlaub Henning , Sattler Michael , Kisielow Jan , Wulczyn F. Gregory , Łyszkiewicz Marcin , Heissmeyer Vigo 
Published: March 2024

AbstractThe regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated in response to T cell receptor (TCR) and Ca2+ signals. Downregulation requires Stim1/Stim2 and CaMK4 expression and involves Arpp21 protein phosphorylation, polyubiquitination and proteasomal degradation. Arpp21 directly binds RNA through its R3H domain, with a preference for uridine-rich motifs, promoting the expression of target mRNAs. Analysis of the Arpp21–bound transcriptome reveals strong interactions with the Rag1 3′-UTR. Arpp21–deficient thymocytes show reduced Rag1 expression, delayed TCR rearrangement and a less diverse TCR repertoire. This phenotype is recapitulated in Rag1 3′-UTR mutant mice harboring a deletion of the Arpp21 response region. These findings show how thymocyte-specific Arpp21 promotes Rag1 expression to enable TCR repertoire diversity until signals from the TCR terminate Arpp21 and Rag1 activities.