bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of binding mechanism of dietary phytochemical, capsaicin, with human transferrin: targeting neurodegenerative diseases therapeutics
Authors: Alrouji Mohammed , Alhumaydhi Fahad A. , Venkatesan Kumar , Sharaf Sharaf E. , Shahwan Moyad , Shamsi Anas 
Published: March 2024

Human transferrin (htf) plays a crucial role in regulating the balance of iron within brain cells; any disruption directly contributes to the development of Neurodegenerative Diseases (NDs) and other related pathologies, especially Alzheimer’s Disease (AD). In recent times, a transition towards natural compounds is evident to treat diseases and this shift is mainly attributed to their broad therapeutic potential along with minimal side effects. Capsaicin, a natural compound abundantly found in red and chili peppers, possess neuroprotective potential. The current work targets to decipher the interaction mechanism of capsaicin with htf using experimental and computational approaches. Molecular docking analysis revealed that capsaicin occupies the iron binding pocket of htf, with good binding affinity. Further, the binding mechanism was investigated atomistically using Molecular dynamic (MD) simulation approach. The results revealed no significant alterations in the structure of htf implying the stability of the complex. In silico observations were validated by fluorescence binding assay. Capsaicin binds to htf with a binding constant (K) of 3.99 × 106 M−1, implying the stability of the htf-capsaicin complex. This study lays a platform for potential applications of capsaicin in treatment of NDs in terms of iron homeostasis.
Bone and bone derived factors in kidney disease
Authors: Simic Petra 
Published: March 2024

Purpose of review: Mineral and bone disorder (MBD) is a prevalent complication in chronic kidney disease (CKD), significantly impacting overall health with multifaceted implications including fractures, cardiovascular events, and mortality. Despite its pervasive nature, effective treatments for CKD-MBD are lacking, emphasizing the urgency to advance understanding and therapeutic interventions. Bone metabolism intricacies, influenced by factors like 1,25 dihydroxy vitamin D, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23), along with intrinsic osseous mechanisms, play pivotal roles in CKD. Skeletal abnormalities precede hormonal changes, persisting even with normalized systemic mineral parameters, necessitating a comprehensive approach to address both aspects.Recent findings: In this review, we explore novel pathways involved in the regulation of systemic mineral bone disease factors, specifically examining anemia, inflammation, and metabolic pathways. Special emphasis is placed on internal bone mechanisms, such as hepatocyte nuclear factor 4α, transforming growth factor-β1, and sclerostin, which play crucial roles in the progression of renal osteodystrophy.Summary: Despite advancements, effective treatments addressing CKD-MBD morbidity and mortality are lacking, necessitating ongoing research for novel therapeutic targets.
Population genetics of Sida fallax Walp. (Malvaceae) in the Hawaiian Islands
Authors: Pejhanmehr Mersedeh , Kantar Michael Benjamin , Yorkston Mitsuko , Morden Clifford W. 
Published: March 2024

IntroductionSida fallax (Malvaceae) is the most widespread and variable taxon of Malvaceae in the Hawaiian Islands, growing with a diversity of morphological forms in different habitats including Midway Atoll, Nihoa, and all the main islands. Morphological variation exists within and among populations. The study aimed to investigate the genetic variation within and among populations from various habitats and geographic locations throughout the Hawaiian range of S. fallax.MethodsA total of 124 samples, with up to five samples per population where possible, were collected from 26 populations across six of the main Hawaiian Islands (Kauaʻi, Oʻahu, Maui, Molokaʻi, Lānaʻi, and Hawaiʻi) and Nihoa in the Northwestern Hawaiian Islands. The sampling strategy encompassed collecting populations from different habitats and geographic locations, including coastal and mountain ecotypes, with many intermediate morphological forms. Multiplexed ISSR genotyping by sequencing (MIG-seq) was used to detect single nucleotide polymorphisms (SNP) and genetic differences among individuals and populations were evaluated using PCO analyses.ResultsThe relationship of FST with the geographical distance between the populations was assessed using the Mantel test. The results showed that populations on a single island were more closely related to each other and to populations on islands within their respective groups than they were to populations on other islands.DiscussionThe overall genetic relationships among islands were, to a large extent, predictive based on island position within the chain and, to a lesser extent, within island topography.
The importance of rapid assessment tools in evaluating mental health in emergency departments among patients with chronic diseases
Authors: Vallath Aditya Lal , Sivasubramanian Barath Prashanth , Ravikumar Diviya Bharathi , Lalendran Akshita , Krishnan Suhasini , Samanta Sudeshna , Banerjee Snigda , Das Tania , Kundu Ritwick , Richharia Vyom , More Ravisha , Khithani Mishika , Nazimudeen Sahana , Gunturu Sasidhar , Dasgupta Indraneel 
Published: March 2024

BackgroundRapid screening tools such as the WHO well-being Index (WWBI), Six-item screener (SIS), and the CLOX-1 test can be used to assess overall mental health and cognition, respectively. We sought to evaluate mental health with cognition in individuals with chronic diseases and stable vital signs presenting to the Emergency Department (ED).MethodsAn observational study in the ED with 279 participants was conducted.ResultsChronic diseases were more prevalent among 51–70 years (43.4%) and diabetes was most common (58.8%). Fever (22.6%) and GI bleeding (32.6%) presentation were high. Participants with low WWBI had low SIS compared to the ones with higher scores (83.3% vs. 17.7%, p &lt; 0.001) and also had low CLOX-1 compared to ones with high CLOX-1 (67.3% vs. 5%, &lt;0.001). A positive correlation between WWBI with SIS (correlation coefficient = 0.305, p &lt; 0.001) and CLOX-1 (0.441, &lt;0.001). Regression analysis indicates a positive association between WWBI and the SIS (standardized regression coefficient = 0.187, 95%CI = 0.236–1.426, and p = 0.006) and CLOX 1 (0.338, 0.2–0.463, &lt;0.001).ConclusionIn the ED, the evaluation of mental health even among cognitive impaired is feasible and crucial.
Assessment of search strategies in Medline to identify studies on the impact of long COVID on workability
Authors: Gehanno Jean-François , Thaon Isabelle , Pelissier Carole , Rollin Laetitia 
Published: March 2024

ObjectivesStudies on the impact of long COVID on work capacity are increasing but are difficult to locate in bibliographic databases, due to the heterogeneity of the terms used to describe this new condition and its consequences. This study aims to report on the effectiveness of different search strategies to find studies on the impact of long COVID on work participation in PubMed and to create validated search strings.MethodsWe searched PubMed for articles published on Long COVID and including information about work. Relevant articles were identified and their reference lists were screened. Occupational health journals were manually scanned to identify articles that could have been missed. A total of 885 articles potentially relevant were collected and 120 were finally included in a gold standard database. Recall, Precision, and Number Needed to Read (NNR) of various keywords or combinations of keywords were assessed.ResultsOverall, 123 search-words alone or in combination were tested. The highest Recalls with a single MeSH term or textword were 23 and 90%, respectively. Two different search strings were developed, one optimizing Recall while keeping Precision acceptable (Recall 98.3%, Precision 15.9%, NNR 6.3) and one optimizing Precision while keeping Recall acceptable (Recall 90.8%, Precision 26.1%, NNR 3.8).ConclusionsNo single MeSH term allows to find all relevant studies on the impact of long COVID on work ability in PubMed. The use of various MeSH and non-MeSH terms in combination is required to recover such studies without being overwhelmed by irrelevant articles.
PENGAMANAN DATA AKTA DENGAN METODE AES BERBASIS CLOUD COMPUTING
Authors: Fadhlil Khaliq Kahfi 
Published: March 2024

Teknologi Cloud Computing sedang ramai digunakan pada saat ini. Cloud Computing yang berarti komputasi awan dalam bahasa indonesia beberapa tahun terakhir telah menjadi keyword terpanas di dunia Teknologi Informasi (TI). Pada Cloud Computing data disimpan di cloud storage dimana data yang kita simpan tidak tersimpan di media penyimpanan data eksternal kita seperti hardisk ataupun flashdisk melainkan tersimpan di internet. File disimpan di dalam server yang tersebar di seluruh dunia. Ketika kita melakukan update pada suatu file pada komputer atau smartphone kita makan file tersebut akan terupdate secara real time. Dengan konsep ini kita dapat mengakses data dimanapun dan kapanpun selama kita memiliki koneksi internet dan device untuk mengaksesnya. Dengan adanya Cloud Computing jelas akan menimbulkan perubahan dalam cara kerja sistem Teknologi Informasi dalam sebuah organisasi. Hal ini karena Cloud Computing melalui konsep virtualisasi, stadarisasi dan fitur mendasar lainnya dapat mengurangi biaya, menyederhanakan pengelolaan layanan TI, dan mempercepat penghatantaran layanan.
PENGGUNAAN METODE C4.5 UNTUK KASUS KLASIFIKASI
Authors: Albert Albert 
Published: March 2024

The use of data mining is very influential in everyday life. Data mining can be used for classification, prediction, association and regression. In data mining, there are many methods that can be used to process large data sets such as the C4.5 algorithm, naive Bayes, K-means and many more.
The C.45 algorithm is one of the methods for classification. The C4.5 algorithm is a modified algorithm of the ID3 algorithm. There are several modifications made to the C.45 algorithm such as continuous attributes as well as missing values. The purpose of the following article is to see words that have been used by previous researchers with the C4.5 method and the results obtained for the cases discussed.
The results of research conducted by previous researchers with the C4.5 method for classification cases received a fairly good accuracy value so that it can be ignored that the C4.5 method is suitable for use in classification cases.
IMPLEMENTASI ALGORITMA APRIORI UNTUK PENENTUAN POLA PERSEDIAAN BARANG PADA UD.CHANDRA JAYA TANI
Authors: Panjaitan Firta Sari 
Published: March 2024

UD.Chandra Jaya Tani merupakan salah satu yang bergerak di bidang penjualan seperti berbagai macam pupuk, pestisida organik pembasmi hama, plastik mulsa, dan keperluan pertanian lainnya, dengan harga yang terjangkau. Dimana perusahan ini setiap harinya harus memenuhi kebutuhan konsumen dan di tuntut untuk mengabil keputusan yang tepat dalam menentukan pola persediaan barang. Permasalahan yang sering terjadi adalah kehabisan persediaan stok barang karena tingkat belanja konsumen yang tidak beraturan dan penumpukan barang yang mengakibatkan kerugian pada UD.Chandra Jaya Tani. Teknik data mining banyak digunakan untuk menyelesaikan masalah salah satunya adalah metode algorita apriori yang digunakan untuk memperoleh informasi tentang asosiasi antar produk dengan manfaatkan database transaksi. Tujuan dari penelitian ini untuk menentukan data persediaan barang dimasa yang akan datang berdasarkan penjualan sebelumnya dengan menerapkan algoritma apriori dimana, Algoritma Apriori adalah logika perhitungan yang menggabungkan suatu produk dengan produk lain melalui data transaksi produk. Hasil yang diperoleh dari penelitian ini adalah algoritma apriori mampu menetukan pola persediaan barang yang sering di minati konsumen dengan minimum support 10% dan confidence sebanyak 20%.
PENUMBUHAN KARAKTER PEDULI LINGKUNGAN MELALUI GERAKAN WORLD CLEAN UP DAY KOTA BIMA
Authors: Taufiqurrahman  , Adnan  , Juhriati  , Imaduddin Asad , Asfarina Sharwanda , Fatur  
Published: March 2024

Program Pengabdian Kepada Masyarakat bertujuan untuk memberikan kesadaran akan pentingnya menumbuhkan karakter peduli lingkungan melalui aksi Clean Up Day dengan agenda bersih pantai serta membuang sampah pada tempatnya dan merawat kebersihan demi menjaga kebersihan di sekitar kita. Kegiatan World Clena Up Day Kota Bima 2023 di ikuti oleh komunitas, pelajar dan Mahasiswa ,NGO, instansi pemerintah kota Bima. Metode yang digunakan dengan sosialisasi program aksi bersih sampah kami 13 Juta ke pemerintah kota bima/instansi, komunitas dan instansi non pemerintah akan pentingnya membersihkan sampah di lingkungan sekitar.. Manfaat yang didapatkan dari kegiatan Pengabdian Kepada Masyarakat antara lain warga Negara muda (generasi Z) dapat menumbuhkan kesadaran akan pentingnya pemahaman peduli lingkungan. Luaran dari Program Pengabdian Kepada Masyarakat ini dapat meningkatkan kesadaran masyarakat Kota Bima akan pentingnya membuang sampah pada tempatnya dan terhindar dari banjir
Assessment of Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus on Insulin Therapy
Authors: Шепелькевич А.П. , Баалбаки Д.Д. , Дыдышко Ю.В. , Юреня Е.В. 
Published: March 2024

В статье представлены результаты собственных исследований по стратификации кардиоваскулярного риска у пациентов с сахарным диабетом 2-го типа, получающих инсулинотерапию. Проведен одномоментный ретроспективный анализ данных медицинской документации 100 пациентов – жителей г. Минска, которые состояли на учете по поводу СД 2-го типа в УЗ «Минский городской клинический эндокринологический центр». Сравнительный анализ частоты встречаемости групп очень высокого риска КВР у пациентов с СД 2-го типа и группы контроля позволил выявить значимо более высокие показатели в основной группе – 90%, чем в группе сравнения – 65% (χ2=17,9; р<0,01). Во всех группах был выявлен уровень HbA1c более 7%, что значительно повышает риск развития кардиоваскулярной патологии. Также в группах с более значимым кардиоваскулярным риском выявлялись более высокие значения гликированного гемоглобина (Н=11,18, p<0,01). У пациентов, имеющих очень высокий риск развития кардиоваскулярной патологии, в основной группе и группе сравнения было выявлено превышение более чем в 2 раза уровня ХС-ЛПНП над целевым значением (<1,4 ммоль/л) для лиц с очень высоким КВР (p<0,01). Анализ полученных данных показал, что в странах с очень высоким риском развития сердечно-сосудистой патологии, в том числе в Республике Беларусь, частота встречаемости макрососудистых осложнений (ИБС и ХСН) значительно выше, чем в странах с низким/умеренным КВР (р<0,01).
This article presents the results of own studies on cardiovascular risk stratification in patients with type 2 diabetes mellitus receiving insulin therapy. A one-time retrospective analysis of medical records of 100 patients from Minsk, who were registered for type 2 diabetes at the Minsk City Clinical Endocrinological Center, was carried out. A comparative analysis of the frequency of occurrence of groups of very high risk of CVR in patients with type 2 diabetes and the control group revealed significantly higher rates in the main group – 90% than in the comparison group – 65% (χ2=17.9; p<0.01). In all groups, an HbA1c level of more than 7% was detected, which significantly increases the risk of developing cardiovascular pathology. Also, in groups with a more significant cardiovascular risk, higher values of glycated hemoglobin were detected (H=11.18, p<0.01). In patients with a very high risk of developing cardiovascular pathology, in the main group and the comparison group, an excess of LDL-C levels over the target value (<1.4 mmol/l) was revealed by more than 2 times for individuals with a very high CVR (p<0. 01). Analysis of the data obtained showed that in countries with a very high risk of developing cardiovascular pathology, including the Republic of Belarus, the incidence of macrovascular complications (CHD and CHF) is significantly higher than in countries with low-moderate CVR (p<0.01).
Early Predictors of Complications in Patients with Arterial Hypertension: Kidney Dysfunction, Arterial Stiffness, Violation of Carbohydrate Metabolism
Authors: Заблоцкая О.В. , Воробьева Е.П. 
Published: March 2024

Основные подходы к ведению пациентов с артериальной гипертензией включают в себя раннее обнаружение признаков дисфункции и повреждения почек, повышения параметров жесткости артерий и нарушений углеводного обмена. Данная стратегия позволит предотвратить развитие осложнений до появления симптомов недостаточности органов-мишеней и замедлить потерю функции данных органов. По данным проведенного исследования, установлены корреляционные связи между жесткостью артерий и дисфункцией почек / концентрацией глюкозы в крови у пациентов трудоспособного возраста с наличием артериальной гипертензии. Жесткость артерий увеличивается по мере увеличения стадии ХБП / увеличения концентрации глюкозы в крови и была выше в группе артериальной гипертензии, чем в общей популяции. Также в ходе выполнения работы определилось новое направление по выявлению ранних предикторов хронической болезни почек – гиперфильтрация. Своевременная диагностика поражения почек и нарушений углеводного обмена при артериальной гипертензии позволяет замедлить или остановить «гипертонический каскад» путем назначения адекватной терапии – кардио-и ренопротективной.
The main approaches to the management of patients with arterial hypertension include early detection of signs of dysfunction and kidney damage, increased parameters of arterial stiffness and disorders of carbohydrate metabolism. This strategy will prevent the development of complications before symptoms of end-organ failure appear and slow down the loss of function of these organs. According to the study, correlations were established between arterial stiffness and kidney dysfunction/blood glucose concentration in patients of working age with arterial hypertension. Arterial stiffness increases with increasing CKD stage/blood glucose concentration and was higher in the hypertension group than in the general population. And also, in the course of the work, a new direction was determined to identify early predictors of chronic kidney disease, hyperfiltration. Timely diagnosis of kidney damage and carbohydrate metabolism disorders in arterial hypertension makes it possible to slow down or stop the "hypertensive cascade" by prescribing adequate therapy – cardio- and renoprotective.
Glucocorticoid-Induced Osteoporosis
Authors: Руденко Е.В. 
Published: March 2024

Глюкокортикоиды являются эффективными иммуномодулирующими препаратами, широко используемыми при лечении многих воспалительных заболеваний, а также у реципиентов трансплантатов. Однако их длительное применение ассоциируется с рядом побочных эффектов и осложнений. Одними из наиболее серьезных состояний, связанных с длительной глюкокортикоидной терапией, являются вторичный остеопороз и низкоэнергетические переломы, которые приводят к значительным социальным и экономическим потерям, снижению качества и продолжительности жизни пациентов. В статье освещены актуальные рекомендации по профилактике, диагностике и лечению глюкокортикоидного остеопороза у взрослых, а также принципы наблюдения за пациентами с данной патологией.
Glucocorticoids are effective immunomodulatory drugs used for many inflammatory disorders as well as in transplant recipients. However, both iatrogenic and endogenous glucocorticoid excess are also associated with several side effects including an increased risk of osteoporosis and fractures. Glucocorticoid-induced osteoporosis (GIOP) is a common secondary cause of osteoporosis in adults. Despite availability of clear evidence and international guidelines for the prevention of GIOP, a large treatment gap remains. The article highlights actual recommendations for the prevention, diagnosis and treatment of GIOP in adults as well as follow-up principles in these patients.
Persepsi Guru Biologi Kabupaten Kolaka Terhadap Implementasi Kurikulum Merdeka di Sekolah
Authors: Tendrita Miswandi , Kaliu Sutriani 
Published: March 2024

Persepsi guru terhadap kurikulum merdeka membantu mengevaluasi dampak kurikulum terhadap pembelajaran. Penelitian kualitatif ini bertujuan menggali pandangan guru-guru biologi di empat sekolah yang sudah menerapkan kurikulum merdeka. Instrumen menggunakan pedoman wawancara yang disusun berdasarkan pedoman wawancara Jannah dan Harun tahun 2023. Teknik Pengumpulan data dilakukan melalui wawancara pada empat guru di sekolah yang telah menerapkan kurikulum merdeka. Hasil penelitian mengungkapkan bahwa: (1) kurikulum merdeka dianggap lebih fleksibel dibanding kurikulum 2013; (2) penilaian sumatif dan formatif sangat ditekankan dalam kurikulum merdeka; (3) Nilai nilai P5 sudah diterapkan dalam pembelajaran namun belum maksimal; (4) penggunaan teknologi juga penting terutama dalam pembelajaran proyek; (5) guru sangat mendukung pembelajaran mandiri siswa meskipun peran sebagai fasilitator tetap diutamakan; (6) guru belum mengetahui sepenuhnya tentang respon siswa terhadap kurikulum ini karena penerapannya belum lama dilakukan; (7) kolaborasi antara guru biologi dalam memaksimalkan penerapan kurikulum ini telah dilakukan meskipun belum maksinal; (8) bagi guru, kurikulum ini memeliki kelebihan terutama dalam proses penyusunan perangkat; (9) sekolah sudah melakukan beberapa upaya agar penerapan kurikulum ini bagi guru dapat maksimal; (10) guru memerlukan pelatihan lebih lanjut mengenai implementasi kurikulum merdeka. Penelitian menunjukkan bahwa meskipun kurikulum merdeka dinilai lebih fleksibel, penerapannya masih memerlukan waktu untuk mendapatkan pemahaman yang lebih mendalam dari para guru, sehingga perlu adanya pelatihan lebih lanjut guna meningkatkan efektivitas implementasinya.
TOTALLY NONHOLONOMIC DISTRIBUTIONS AND SUB-RIEMANNIAN STRUCTURES
Authors: Kilela Michael Makiese , Lungiambudila Oscar , Kabuya Joel , Matumona Dieumerci 
Published: March 2024

In this paper, we study totally non-holonomic distributions and sub-riemannian structure on Rn (n = 1, 2, 3, 4, ...) and on the manifolds of not null curvature such as Tn and Sn with n more or equal than 3, in order to look at this structure on a manifold like a restricting of a Riemannian metric on a totally non-holonomic distribution of this manifold. On Rn, it always possible to construct this structure thanks to her multitude of smooth distributions and vector elds. On the manifolds of not null curvature, we de ne this structure on the kernel of a non-degenerate 1-form or of contact form on this manifold.
Gestão de projetos complexos e incertos no contexto de desastres naturais: o caso do projeto de gestão integrada em riscos
Authors: Honorato Gomes Daniel , Marotti de Mello Adriana , Lucia Granja Coutinho Maria 
Published: March 2024

O significativo impacto das mudanças climáticas tem provocado fenômenos extremos, onde o aumento da temperatura vem causando efeitos devastadores, da morte de corais nos oceanos, passando pelo derretimento das geleiras a incêndios em grandes áreas florestais. A prevenção e mitigação dos efeitos de desastres naturais passam a ser prioritários. Projetos dessa natureza apresentam características únicas, como alto grau de incerteza, complexidade, falta de dados e de retorno financeiro mensurável, o que torna sua gestão desafiadora. A identificação de metodologia de projetos complexos e incertos no contexto de desastres naturais foi realizada por meio da metodologia qualitativa aplicada ao método de estudo de caso único. O objetivo deste artigo foi identificar quais características de gestão de projetos complexos e incertos contribuem para o desenvolvimento de inovações para mitigar efeitos de desastres naturais. Como principais resultados obtidos, mostrou-se que a estrutura formal deve estar fundamentada nas áreas de conhecimentos: integração, escopo, custos, qualidade, recursos humanos, comunicação, riscos, aquisição, e partes interessadas e melhores práticas em gestão de projetos complexos e incertos identificadas.