bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase III Study of Capecitabine Plus Oxaliplatin Compared With Continuous-Infusion Fluorouracil Plus Oxaliplatin As First-Line Therapy in Metastatic Colorectal Cancer: Final Report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial
Authors: Díaz-Rubio Eduardo , Tabernero Jose , Gómez-España Auxiliadora , Massutí Bartomeu , Sastre Javier , Chaves Manuel , Abad Alberto , Carrato Alfredo , Queralt Bernardo , Reina Juan José , Maurel Joan , González-Flores Encarnación , Aparicio Jorge , Rivera Fernando , Losa Ferrán , Aranda Enrique 
Published: June 2007

Purpose The aim of this phase III trial was to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) versus Spanish-based continuous-infusion high-dose fluorouracil (FU) plus oxaliplatin (FUOX) regimens as first-line therapy for metastatic colorectal cancer (MCRC). Patients and Methods A total of 348 patients were randomly assigned to receive XELOX (oral capecitabine 1,000 mg/m2 bid for 14 days plus oxaliplatin 130 mg/m2 on day 1 every 3 weeks) or FUOX (continuous-infusion FU 2,250 mg/m2 during 48 hours on days 1, 8, 15, 22, 29, and 36 plus oxaliplatin 85 mg/m2 on days 1, 15, and 29 every 6 weeks). Results There were no significant differences in efficacy between XELOX and FUOX arms, which showed, respectively, median time to tumor progression (TTP; 8.9 v 9.5 months; P = .153); median overall survival (18.1 v 20.8 months; P = .145); and confirmed response rate (RR; 37% v 46%; P = .539). The safety profile of the two regimens was similar, although there were lower rates of grade 3/4 diarrhea (14% v 24%) and grade 1/2 stomatitis (28% v 43%), and higher rates of grade 1/2 hyperbilirubinemia (37% v 21%) and grade 1/2 hand-foot syndrome (14% v 5%) with XELOX versus FUOX, respectively. Conclusion This randomized study shows a similar TTP of XELOX compared with FUOX in the first-line treatment of MCRC, although there was a trend for slightly lower RR and survival. XELOX can be considered as an alternative to FUOX.
Hematologic and Blood Biochemistry Monitoring During Methylphenidate Treatment in Children With Attention-Deficit/Hyperactivity Disorder: 2-Year, Open-Label Study Results
Authors: Wigal Sharon B. , Wilens Timothy E. , Wolraich Mark , Lerner Marc 
Published: June 2007

OBJECTIVES. Patients receiving methylphenidate for the management of attention-deficit/hyperactivity disorder are recommended to receive periodic hematologic monitoring. The objective of this study was to evaluate the long-term effects of methylphenidate treatment on blood biochemistry and hematologic values.
METHODS. This study involved a detailed analysis of changes in hematologic and blood biochemistry values over the course of a 2-year study of once-daily OROS methylphenidate in otherwise healthy children aged 6 to 13 years with attention-deficit/hyperactivity disorder. Routine hematologic and blood biochemistry assessments were performed at baseline, at 6 and 12 months during study treatment, and at the end of the study.
RESULTS. Of the 407 subjects enrolled in the study, 289 completed year 1, and 229 completed 21 of 24 months. No subject was excluded from entry into the study or discontinued from the study because of abnormalities of any of the blood chemistries evaluated. There were no clinically significant changes from baseline in mean values for hematologic or blood biochemistry parameters. For most values, the mean change in value over the course of the study was &lt;5%.
CONCLUSIONS. These longer-term data suggest that chronic therapy with OROS methylphenidate has no clinically significant impact on laboratory values, challenging the necessity of routine hematologic monitoring in otherwise healthy children with attention-deficit/hyperactivity disorder who are treated with methylphenidate.
Growth and Growth Hormone Therapy in Subjects With Mulibrey Nanism
Authors: Karlberg Niklas , Jalanko Hannu , Lipsanen-Nyman Marita 
Published: June 2007

OBJECTIVES. Mulibrey nanism is a monogenic disorder with prenatal-onset growth restriction, mild dysmorphic features, and a strong tendency for insulin resistance but no major neurologic handicap. Growth hormone therapy has been shown to promote short-term growth in children born small for gestational age, but the experience with long-term therapy is insufficient. Growth in patients with mulibrey nanism has not been analyzed previously in detail.
METHODS. We evaluated the natural growth pattern and long-term impact of growth hormone treatment in the largest cohort of subjects with mulibrey nanism to date. The study included 72 living subjects followed up to 30 years. Thirty (18 female) were treated with recombinant human growth hormone for a median period of 5.7 years. Patients were reviewed at baseline and every 6 to 12 months during the therapy. Evaluation included assessment of height, weight, and pubertal status and laboratory analyses. Glucose metabolism was evaluated by oral glucose-tolerance test.
RESULTS. The patients were born small for gestational age with immature craniofacial features. They experienced a continuous deceleration in height (median decrement of 1.1 SDS) and weight for height (median reduction of 17%) in infancy followed by an incomplete catch-up growth lasting up to school age. The final adult height averaged 136 cm in girls and 150 cm in boys. Growth hormone treatment improved the prepubertal growth but had only little impact on adult height (+5 cm). The treated subjects showed earlier bone maturation and growth arrest but not a significant increase in insulin resistance. On the contrary, the subjects who were treated with growth hormone were slimmer and had less metabolic syndrome as young adults.
CONCLUSIONS. The patients with mulibrey nanism showed a distinct postnatal growth pattern. The growth hormone treatment was safe and induced a good short-term effect, but the impact on the adult height remained modest.
Seasonal Dynamics of Mycorrhizal Colonization in the Rhizosphere of Some Dominant Halophytes
Authors: Füzy A. , Tóth T. , Biró Borbála 
Published: June 2007

Dominant halophytes, such
as
Plantago maritima, Aster tripolium, Artemisia santonicum, Puccinellia
limosa, Festuca pseudovina
and
Lepidium crassifolium
were monitored
for their colonization by arbuscular mycorrhizal fungi (AMF) for two vegetation
periods, sampled by monthly frequency. Two saline sites (A: Apaj-puszta and Z:
Zabszék) were selected for the survey due to their similar physical and
chemical soil characteristics (including the salt level and salt specific
anions) and the distinct site use (pasturing or not) or water regime (as
drought or temporally flooded at the vicinity of the Zabszék lake). Colonization of arbuscular mycorrhizal
fungi greatly depended on the plant species and their physiological status,
such as the mycotroph or non-mycotroph character. In this respect the highest
mycorrhizal intensity (M%) and arbusculum richness (A%) was found on the
Plantago
maritima
, while
Puccinellia limosa
was the less dependent species on
mycorrhiza fungi. A characteristic
seasonal dynamism was found at both saline sites, for all sampled halophytes. A
maximum mycorrhizal colonization was recorded in late spring and early summer,
when there was an increased plant-physiological initiative
for the helpful symbiosis (i.e. intensive vegetative and/or generative phases
of the hosts). The rate of fungal
intensity in the root system (M%), and especially the arbusculum richness (A%)
on the other hand was found to be dependent on the site use and the water
fluctuation in the soils. A more versatile dynamism of the mycorrhizal
colonization was found therefore at the vicinity of the Zabszek lake with the
permanent water fluctuations. Under more drought stressed conditions an
increased mycorrhizal colonization and functioning (arbusculum richness) was
found, generally preceeding the high environmental stress, which was
deleterious for both symbiont partners. Such mycorrhizal dynamism in the
rhizosphere, however, seems to be a common strategy between the hosts and the
microsymbionts in the “struggle for life” process in the Hungarian steppe.
Modelling of Soil Respiration in Hungary
Authors: Ács Ferenc , Breuer H. 
Published: June 2007

The climatology of soil respiration in Hungary is
presented. Soil respiration is estimated by a Thornthwaite-based biogeochemical
model using soil hydrophysical data and climatological fields of precipitation
and air temperature. Soil respiration fields are analyzed for different soil
textures (sand, sandy loam, loam, clay loam and clay) and time periods (year,
growing season and months). Strong
linear relationships were found between soil respiration and the actual evapotranspiration
for annual and growing season time periods. In winter months soil respiration
is well correlated with air temperature, while in summer months there is a
quite variable relationship with water balance components. The strength of
linear relationship between soil respiration and climatic variables is much
better for coarser than for finer soil texture.
Presentation procedures in lineups and mug books: a direct comparison
Authors: McAllister Hunter A. , Michel Lacie L. M. , Tarcza Erin V. , Fitzmorris J. Michael , Nguyen Kim H. T. 
Published: June 2007

AbstractThe purpose of this research was to replicate and to extend past findings that the best procedure for presenting lineup pictures is not the best procedure for presenting mug book pictures. Participants witnessed a videotape of a simulated crime that was followed by a lineup task for half the participants or a mug book task for the other half. The task factor was crossed with two other factors: (a) a presentation procedure factor—pictures presented one‐at‐a‐time or grouped 12 per page and (b) a presence of the perpetrator factor—perpetrator present or absent in the viewed pictures. For perpetrator‐absent conditions, the one‐at‐a time lineup procedure produced more correct rejections than the grouped lineup procedure replicating past results; however, for the mug book task the two presentation procedures did not differ. For perpetrator‐present conditions, the grouped presentation procedure produced more correct identifications than the one‐at‐a time procedure in both lineups and mug books. The different pattern of results for lineups and mug books was explained in terms of differences in response criterion. Copyright © 2007 John Wiley & Sons, Ltd.
Maternally inherited duplication of chromosome 7, dup(7)(p11.2p12), associated with mild cognitive deficit without features of Silver–Russell syndrome
Authors: Leach Natalia T. , Chudoba Ilse , Stewart Tasheena V. , Holmes Lewis B. , Weremowicz Stanislawa 
Published: June 2007

AbstractWe report on a familial duplication in the short arm of chromosome 7, dup(7)(p11.2p12), present in three generations. The duplication was identified by GTG‐banding and fluorescence in situ hybridization (FISH) with a whole chromosome 7 DNA painting probe that verified that the duplicated material originated from chromosome 7. The multicolor banding (mBAND) was used to refine the breakpoint assignment. The duplication identified in the proband was also present in her son and mother. All three carriers have mild cognitive deficiencies. Interstitial duplications of the short arm of chromosome 7, although relatively uncommon, have been described in association with a variety of clinical features, including mental retardation of varying severity. Duplication of the p11.2p13 region on chromosome 7 was reported in association with Silver–Russell syndrome (SRS), and an overlapping dup(7)(p11.2p14.1)dn was described in an individual with autistic disorder. Furthermore, a potentially overlapping maternally transmitted inverted duplication, dup(7)(p13p12.2), was reported in patients with cognitive delay. These observations and the phenotype of our duplication carriers suggest that partial trisomy of the proximal 7p region causes cognitive deficiency. The maternal origin of the duplication is of special interest in light of genomic imprinting and implication of the 7p11‐p13 region in the SRS etiology. Locus‐specific FISH targeting a growth factor receptor binding protein 10 (GRB10), the strong candidate for SRS residing at 7p12.2, showed that it is not duplicated in our patients. Our study helps refine the SRS critical region on 7p and extends our understanding of the clinical manifestations associated with 7p duplications. © 2007 Wiley‐Liss, Inc.
Congenital fibrosis of the extraocular muscles (CFEOM) syndrome associated with progressive cerebellar ataxia
Authors: Yoshida Kunihiro , Okano Tomomi , Hoshi Kenichi , Yahikozawa Hiroyuki , Suzuki Kayo , Banno Haruhiko , Tamura Takuya , Sobue Gen , Ikeda Shu‐ichi 
Published: June 2007

AbstractWe here report on a Japanese family with congenital fibrosis of the extraocular muscles (CFEOM) syndrome associated with slowly progressive cerebellar ataxia. The pedigree indicated autosomal dominant inheritance. All affected individuals showed a complete loss of upgaze function with ptosis, and severe or moderate restriction of downgaze function probably from the birth. Horizontal gaze function was well preserved, except for the eldest patient, who showed both eyes almost totally fixed in exotrophic position. The primary vertical and horizontal position of each eye varied from patient to patient. Aberrant eye movements were observed on attempted upgaze. They showed amblyopia and/or astigmatism, but none of them complained of diplopia. Pupillary reactions were normal, and retinal pigmentary degeneration or optic atrophy was not observed. These ophthalmological findings were consistent with the CFEOM phenotype. The two middle‐aged patients, but not the two younger patients, showed slowly progressive gait ataxia with juvenile onset. Magnetic resonance images of the brain indicated cerebellar atrophy in addition to congenital hypoplasia in the cerebellar vermis. Molecular genetic analysis provided a negative linkage to the FEOM3 locus. Linkage to the FEOM1 locus could not be excluded in our family, but mutation in KIF21A, a major cause of the CFEOM1 phenotype, was not detected. We consider that this family may broaden the spectrum of the clinical features of CFEOM or the related disorders presenting with the CFEOM phenotype. © 2007 Wiley‐Liss, Inc.
Elongational rheology by different methods and orientation number
Authors: Collier John R. , Petrovan Simioan , Hudson Nick , Wei Xiaoling 
Published: June 2007

AbstractThe elongational rheology of polymer melts was measured by the authors using the hyperbolic convergent die technique and the results were compared with the same samples measured using a Meissner type device or an Instron tensile tester. Polyethylene and polystyrene samples were tested at Eidgenössische Technische Hochschule‐Zürich or Virginia Polytechnic Institute, and the polyisobutylene was part of a world wide “Round Robin” comparison. A modified Weissenberg number, i.e., an Orientation number, is suggested to explain the agreement between techniques for some samples and lack of agreement for others. The Orientation number is the product of Hencky strain, elongational strain rate, and average relaxation time. When it is less than one a relaxation dominant regime results, when greater than one an orientation dominant regime results, and near one a transition occurs. For the hyperbolic convergent die technique, in which the polymers are transversely constrained by the walls, the extrudates in the transition regime have slight surface defects and the pressure fluctuates more than in the other regimes. If the transition occurs after significant time, i.e., lower elongational strain rates, in the free boundary Meissner and Instron devices, the samples apparently experience more relaxation since unconstrained transversely (and perhaps differential thinning) leading to disagreement with the hyperbolic die measurements. The orientation related body forces are magnitudes larger than the shearing forces and cause slip at the wall in the hyperbolic dies in the orientation dominant regime. Even in the relaxation dominant regime, shear near the wall is a minor contributor to the necessary pressure force. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Combined forecast impact of GRACE‐A and CHAMP GPS radio occultation bending angle profiles
Authors: Healy S. B. , Wickert J. , Michalak G. , Schmidt T. , Beyerle G. 
Published: June 2007

AbstractImpact experiments assimilating GRACE‐A and CHAMP GPS radio occultation (GPSRO) bending angle profiles are presented. The standard deviation of the observation minus background bending angle departures above 35‐km is 30% smaller for GRACE‐A than CHAMP, indicating that the GRACE‐A measurements are more accurate. Assimilating the GPSRO measurements improves stratospheric temperatures in the Southern Hemisphere. The combined impact of GRACE‐A and CHAMP is greater than assimilating either instrument individually. Copyright © 2007 Royal Meteorological Society
Direct observation of quality of care in residential settings
Authors: Zarcone Jennifer R. , Iwata Brian A. , Rodgers Teresa A. , Vollmer Timothy R. 
Published: June 2007

AbstractDirect‐observation procedures were used to objectively and efficiently assess several classes of service provided for individuals residing at two state facilities for the developmentally disabled. Time samples were taken of the condition of the clients' physical environment and of the clients themselves. The ongoing behavior of both clients and staff also was recorded. Each residence was observed at least three times during both regular work hours and evening/weekend hours. Results showed that both facilities scored high in the categories regarding the physical condition of the living areas, as well as the categories concerning the condition of the clients. Greater variability was seen in the data on client and staff behavior. More generally, the results indicate that time‐sampling procedures can be used efficiently to collect data on multiple aspects of service delivery for large numbers of individuals.
Delusional verbalizations and beliefs
Authors: Himadi Bill , Osteen Frances , Crawford Ellen 
Published: June 2007

AbstractThis study evaluated the intensity of delusional beliefs during the modification of delusional verbalizations with three chronically mentally ill inpatients. The multiple‐baseline across responses design was used to evaluate the efficacy of a behavioral treatment package to modify delusional verbalizations. Results revealed that changes were obtained in delusional verbalizations to personal questions without corresponding changes in the subjects' delusional beliefs. Changes in delusional verbalizations were well‐maintained for two subjects during a 6‐month follow‐up period. Mixed results were obtained for generalization probe interviews.
Brief report: Compliance in the classroom: Using the „thumbs up”︁ procedure to increase student compliance to teacher requests
Authors: Glass Margaret , Houlihan Daniel , Fatis Michael , Levine Howard 
Published: June 2007

AbstractThis study assessed the effectiveness of a program designed to increase compliance with teacher commands in a regular 5th grade math class. A reversal design (A‐B‐B'‐A‐B') was employed. The teacher used a discriminative stimulus to signal the students as to the availability of an opportunity to earn a point towards a reinforcer. To receive the point the students were required to return the signal and initiate compliance. The entire class was involved in the program; however, data were recorded on two students, one identified by the teacher as noncompliant; the other served as a control. The results indicated that the program was effective in increasing initiation of compliance to teacher commands. However, serious questions were raised about the generalizability of such a program.
Setting up inpatient behavioral treatment programs: The staff needs assessment
Authors: Corrigan Patrick W. , Holmes E. Paul , Luchins Daniel , Parks Joseph , Basit Abdul , Delaney Ethel , Kayton‐Weinberg Donna 
Published: June 2007

AbstractDespite the success that behavior therapy has demonstrated in treating severely mentally ill adults, widespread impact of behavioral treatments on this population has been limited because the staff of many inpatient settings do not routinely utilize these strategies. Surveying staff regarding their perception of programatic and organizational needs is proposed as a valuable first step for selecting behavioral strategies to be introduced in these settings. Goldfried and D'Zurilla (1969) developed a behavioral assessment survey that is especially useful for identifying staff needs vis‐à‐vis behavioral rehabilitation. Using these strategies, survey questions addressed five problem areas: Administrative, Staff, Patient, Resource, and Programatic. Results using this survey with 40 clinicians on the extended care unit of a state hospital showed that staff members had greatest concern with the Patient Problem Area (i.e., aversive patient behaviors that are not sufficiently addressed by treatment plans). Further analyses showed staff members were interested in addressing Patient concerns using incentive procedures. The needs assessment in this study not only provided useful information that might be generalized to other treatment settings, but also showcased a reliable survey approach that program developers might implement prior to designing training curricula for behaviorally naive staff in inpatient settings.
Training direct service staff in congregate settings to interact with people with severe disabilities: A quick, effective and acceptable program
Authors: Schepis Maureen M. , Reid Dennis H. 
Published: June 2007

AbstractAn area of traditional as well as recent concern in congregate settings for people with severe disabilities is ensuring frequent social interactions between direct service staff and individuals who live in the residences. This study evaluated a program for training staff to interact frequently and positively across clients while in group situations in living units. The program involved a short classroom instructional session encompassing less than 1 h, followed by a maximum of 4 brief on‐the‐job observations and feedback sessions. Results indicated interaction rates of all 9 participating direct service staff increased above a normative criterion rate while participating in the training program. All staff also increased the proportion of their social interactions with clients that were positive in nature, and 6 of the 9 staff increased their distribution of interactions across clients. The improved interaction performances occurred when staff were provided with immediate on‐the‐job feedback regarding their performances as well as when provided with delayed feedback. Acceptability measures indicated the training program was well received by staff, although program components also were noted that may have affected staff acceptance differentially. Directions for future research are suggested in regard to further evaluating and increasing staff acceptance of effective training procedures.