bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACSM3 Suppresses Ovarian Cancer Progression by Inactivating the IFN‐γ/JAK/STAT3 Signaling Pathway
Authors: Wang Juan , Sun Yanqiu , Wu Ruixue 
Published: February 2025

AbstractThis study aimed to investigate the role of Acyl‐CoA medium‐chain synthetase 3 (ACSM3) in ovarian cancer (OC) progression. ACSM3 expression in OC tissues and cells is detected by real‐time quantitative polymerase chain reaction, immunohistochemistry, or western blot. The influences of ACSM3 on OC progression are assessed in vitro and in vivo experiments. Gene set enrichment analysis is performed to find significantly enriched pathways related to ACSM3. In this study, ACSM3 expression in OC tissues and cells is downregulated. ACSM3 inhibited tumor growth in vivo. Knockdown of ACSM3 promoted cell proliferation, migration, and invasion, inhibited cell apoptosis, and activated JAK/STAT3 signaling pathway in SKOV3 cells, while overexpression of ACSM3 in A2780 cells led to the opposite results. Moreover, treatment with interferon‐gamma (IFN‐γ) in A2780 cells reversed the effects of ACSM3 on cell proliferation, migration, invasion, and apoptosis, but IFN‐γ further enhanced the effects of ACSM3 knockdown on SKOV3 cell proliferation, migration, invasion, and apoptosis. In conclusion, ACSM3 inhibited OC cell proliferation, migration, and invasion, and promoted cell apoptosis by suppressing the IFN‐γ/JAK/STAT3 signaling pathway, which might provide a promising therapeutic target for OC treatment.
Generation of Advanced Blood–Brain Barrier Spheroids Using Human‐Induced Pluripotent Stem Cell‐Derived Brain Capillary Endothelial‐Like Cells
Authors: Mathew‐Schmitt Sanjana , Oerter Sabrina , Reitenbach Evelin , Gätzner Sabine , Höchner Alevtina , Jahnke Heinz‐Georg , Piontek Jörg , Neuhaus Winfried , Brachner Andreas , Metzger Marco , Appelt‐Menzel Antje 
Published: February 2025

AbstractExtensively studied blood–brain barrier (BBB) in‐vitro models are established on 2D cell culture inserts. However, they do not accurately represent 3D in‐vivo microenvironments due to lack of direct neurovascular unit cellular contacts. Here, the establishment and characterization of a self‐assembled 3D BBB spheroid model using human‐induced pluripotent stem cell (hiPSC)‐derived brain capillary endothelial‐like cells (iBCECs) in combination with primary human astrocytes (ACs) and pericytes (PCs) are reported. This investigation compares 3D spheroids with 2D mono‐cultured iBCECs derived from two different hiPSC lines and two differentiation strategies. It is observed that spheroid properties vary depending on the differentiation strategy or type of hiPSC line applied for model generation. However, spheroids demonstrate in‐vivo like tight junction ultrastructure and, in comparison to 2D models, higher transcript expression of BBB specific genes. Furthermore, they possess characteristic barrier integrity, barrier functionality, and protein expression. It is inferred that hiPSC‐derived BBB spheroids hold a strong potential as a reliable future BBB in‐vitro test system.
Exceptional Cooling Capacity of LiGd0.1Yb0.9F4 at Sub‐Kelvin Temperatures
Authors: Xu Qiao‐Fei , Zhao Peng , Chen Man‐Ting , Wu Ruo‐Tong , Dai Wei , Long La‐Sheng , Zheng Lan‐Sun 
Published: February 2025

AbstractAdiabatic demagnetization refrigeration, which utilizes the magnetocaloric effect of magnetic refrigerants, stands as the sole cooling technology capable of achieving sub‐Kelvin temperatures efficiently and reliably without relying on scarce 3He resources or gravity. However, current sub‐Kelvin magnetic refrigerants encounter challenges such as structural instability in vacuum or under mild heating, along with small magnetic entropy change (−ΔSm) values, which significantly limit their practical applications. Here a water‐free magnetic refrigerant, LiGd0.1Yb0.9F4 is reported, prepared by introducing Li⁺ ions to reduce the dipolar interactions between Gd3+ ions and/or Yb3+ ions. Notably, this refrigerant possesses a magnetic ordering temperature of 85 mK, while its experimental −ΔSm reaches up to 136 mJ cm−3 K−1 (0.68 K and 2 T), more than three times the theoretical value of CrK(SO4)2·12H2O. Significantly, this refrigerant not only cools the test sample to temperatures as low as 160 mK but also achieves a specific cooling capacity of 46.943 mJ cm−3 T−1 at 300 mK. Remarkably, the specific cooling capacity at 300 mK is more than double that of commercial CrK(SO4)2·12H2O, representing one of the most notable values reported among all known magnetic refrigerants operating at sub‐Kelvin temperatures.
Chitosan‐Graft‐Gelatin Hydrogel Containing Bromothymol Blue as a Food Spoilage Indicator for Intelligent Food Packaging
Authors: Far Bahareh Farasati , Jahanbakhshi Mehdi , Jameie Leila , Shojaei Asefeh , Zarei Kimia , Taromi Parsa , Jafarzadeh Shima , Ertas Yavuz Nuri 
Published: February 2025

AbstractA remarkable one‐third of global food production is wasted, resulting in significant economic damage and escalating food insecurity. To address this sustainability challenge, freshness identification in food packaging using intelligent materials has gained traction. This work introduces a chitosan‐graft‐gelatin (CS‐g‐GEL) hydrogel, incorporating a pH‐responsive dye, bromothymol blue (BTB), as a colorimetric freshness indicator to monitor the spoilage of chicken breasts. The successful formulation of the hydrogels is verified using FTIR, AFM, SEM, TGA, and 1HNMR characterization techniques. At pH 5 and pH 7.4, the swelling capacity of the hydrogel is 790% and 470%, respectively. A rise in colony‐forming units (CFU) from 5.5 on day 1–7.4 log CFU g−1 on day 7 indicate microbial activity, and the production of carbon dioxide due to deteriorating food freshness decreases the pH in the food package. Additionally, CO2 concentrations rise from 3.2 on day 1–22.1 (% v/v) on day 7, while O2 levels decreases from 23.8 to near 0.5 (% v/v) in the same period. The developed hydrogel is demonstrated to serve as a smart and visual indicator of food freshness and offers a new dimension in the use of intelligent materials toward a global challenge.
Active Luminous Quantum Dot Self‐Assembled Microsphere Volumetric Display
Authors: Li Guihai , Liu Ruixiang , Wang Lei , Zhao Leilei , Yang Xiaoting , Shen Huaibin , Fan Fengjia 
Published: February 2025

AbstractVolumetric display is a type of technology that generates visuals in three dimensions. The image formed in this manner can be viewed with the naked eye without the need for any wearable device. The volumetric display generates a 3D image that is real in size and appears to be a vivid object that can be viewed from any direction, allowing the viewer to interact with the image. A volumetric display technique based on light‐emitting colloidal quantum dots (CQDs) is developed, thanks to their flexible assembly capability, low heat conductivity, and attainable high photoluminescence quantum yield (PLQY). This approach uses a single laser beam to create a 3D display with a micrometer resolution. The effect of CQD's heat capacity and heat conductivity on the microsphere's photophoretic force (PPF) is investigated, and the results suggest that only heat conductivity has a significant impact on the PPF. It is also discovered that the shape and size of the microsphere have a great impact on the PPF; microspheres with a diameter comparable to the size of the optical trap, or with a nonspherical shape, are more easily captured.
High‐Performance Self‐Driven MAPbI3‐MAPbBr3 Perovskite Single Crystal Heterojunction Photodetectors for Ultra‐Sensitive Weak Light Imaging
Authors: Liu Chenyang , Wang Rui , Liu Jialin , Xu Wenli , Zhang He , Liu Xinying , Huo Xiangyu , Cui Xueying , Sun Haiqing , Liu Rui , Zhu Huiling , Zhang Weiwei , Ding Jianxu 
Published: February 2025

AbstractThe rapid advancement of optoelectronic devices, particularly photodetectors, demands enhanced sensitivity for detecting weak light. In this study, MAPbI3‐MAPbBr3 perovskite single crystal heterojunctions (SCHs) are fabricated via atomic force bonding using liquid‐phase epitaxy, with polydimethylsiloxane (PDMS) serving as a substrate protector. The resulting SCHs photodetector exhibits self‐driven operation, an ultra‐low dark current, and a high on‐off ratio of 5.8 × 104 at 0 V bias. Under weak illumination and 5 V bias, the device achieves a maximum external quantum efficiency of 414.9%. With a remarkable detection rate of 4.5 × 1013 Jones, the device demonstrates outstanding potential for weak light imaging. Furthermore, the self‐driven SCHs photodetector enables high‐quality imaging under a 445 nm light source at a remarkably low intensity of 2.7 µW cm−2, without the need for any external power supply.
Porous Metallophilic Frameworks Incorporating Metal–Organic Chains as Humidity Sensors Exploring Uranyl Photoluminescence
Authors: Zakrzewski Jakub J. , Jędrzejowski Damian , Wang Junhao , Tokoro Hiroko , Ohkoshi Shin‐ichi , Matoga Dariusz , Chorazy Szymon 
Published: February 2025

AbstractLuminescent coordination polymers, including metal–organic frameworks, serve as a platform for optical sensing of physical and chemical stimuli, including temperature or pressure for the former, gases, solvent vapors, explosives, toxic species, etc. for the latter. The related materials built of uranyl cations, UO22+, remain unexplored, despite their tunable photoluminescence. While recently, bimetallic coordination and supramolecular systems built of cyanido metal complexes have proven a successful pathway toward stimuli‐responsive materials, their combination with uranyl species is limited. Here, the construction of novel uranyl‐based systems demonstrating a distinct sensitivity of emission to solvent vapors is reported, which is achieved by generating metal–organic, i.e, uranyl–2,4′‐bipyridine‐N,N’‐dioxide, chains that are arranged into a porous supramolecular framework by metallophilic interactions between attached tetracyanidometallates(II), [MII(CN)4]2− (MII = Pd, 1; Pt, 2). Both resulting materials reveal reversible single‐crystal‐to‐single‐crystal transformation upon removal of crystallization solvent molecules, which is due to the flexibility of metallophilic interactions forming a porous metallophilic framework resembling MOF‐74. The presence of infinite channels introduces sensing capabilities to water vapors while the emissive character leads to the humidity‐variable emission characteristics, including the strong variation in emission intensity and lifetime. The obtained systems exhibit repeatable adsorption and emission characteristics, meeting the criteria for luminescent sensors.
Smart Targeting Layer on Silver Nanowire Electrodes Achieving Efficiency Breakthroughs in ITO‐Free Conventional Flexible Organic Solar Cells
Authors: Xia Jinfeng , Zhu Juan , Chen Haiyang , Zeng Guang , Wan Juanyong , Zhang Ben , Lee Seunglok , Xu Jiacheng , Cao Jianlei , Wu Xiaoxiao , Ding Junyuan , Yang Leishuo , Chen Weijie , Yang Changduk , Li Yaowen , Li Yongfang 
Published: February 2025

AbstractSilver nanowire (AgNW) electrodes, known for their intrinsic flexibility and tunable optoelectronic properties, have garnered considerable attention for use in flexible organic solar cells (OSCs). However, in conventional OSCs, their low work function (WF) causes energy‐level mismatches with classic aqueous hole transport layers (HTLs), while their poor hydrophilicity hinders the formation of optimized HTL morphology and crystallinity, posing challenges to their integration into high‐performance OSCs. To address these issues, functionally targeted molecules with a thiol group at one end and strong electron‐withdrawing, hydrophilic functional groups at the other are precisely engineered to wrap around the AgNW electrodes. The thiol group facilitates the formation of robust self‐assembled molecules (SAMs) on the AgNW electrodes through stable S−Ag chemical bonds at room temperature. The strong electron‐withdrawing groups generate notable molecular and interfacial dipoles that effectively raise the WF of AgNW electrodes. Notably, the hydrophilic groups not only improve electrode wettability but also promote strong hydrogen bonding interactions with HTL, leading to substantial improvements in the morphology and crystallinity of the HTL. This precision wrapping strategy enables the fabrication of high‐efficient conventional flexible OSCs, achieving a record power conversion efficiency of 18.84 % (certified at 18.56 %) for flexible OSCs based on ITO‐free transparent electrodes.
Comparison of Catalytic Behaviors of Brønsted Versus Lewis Acidic MOFs in Synthesis of 2,4,5‐Trisubstituted Imidazoles
Authors: Devarajan Nainamalai , Saravanakumar Natarajan , Suresh Palaniswamy 
Published: February 2025

ABSTRACTThe catalytic efficacy of the Lewis acidic site in Cu3(BTC)2 MOF was compared with the Brønsted acidic site in MIL‐101‐SO3H MOF. Both Lewis and Brønsted acidic MOFs demonstrate strong conversion rates in the synthesis of 2,4,5‐triaryl imidazoles through a one‐pot multicomponent reaction under a microwave condition. This outcome underscores the stability and reusability of both MOFs. The catalytic activity of the MOFs relies on the facile accessibility of catalytically active centers/sites to the reactants. Superior results were achieved with MIL‐101‐SO3H MOF's Brønsted acidic sites compared with Cu3(BTC)2 MOF's Lewis acidic sites due to the latter's shortcomings in reusability and stability as a catalyst in the synthesis of 2,4,5‐TSIs (2,4,5‐trisubstituted imidazoles). MIL‐101‐SO3H MOF can be reused multiple times without any loss in its catalytic activity, as demonstrated by hot filtration tests and various analytical techniques such as FTIR, powder XRD, SEM, and EDAX conducted on both fresh and reused MOF catalysts.
Response Surface Method (RSM) Process Optimization of Sulfides Oxidation in the Presence of Orange Peel Extract Immobilized Magnetic Hybrid Nanocomposite Catalyst
Authors: Tamoradi Taiebeh , Zarei‐Ahmady Amanollah , Karmakar Bikash , Nabizade Nafise 
Published: February 2025

ABSTRACTThe oxidative transformation of sulfides to sulfoxides over magnetic green catalysts is one of the most important applications in pharmaceuticals. In this report, we demonstrate the step‐by‐step fabrication and synthesis of CoFe2O4, CuFe2O4, and Fe3O4 nanocomposite modified with orange peel extract complexes as advanced high‐performance magnetic nanocomposite materials. One of the goals of this project was to use phenolic acid phytochemicals in the catalytic process. The newly synthesized nanocomposites were characterized by several advanced analytical methods. Utilizing the Box–Behnken experimental design and the response surface methodology (RSM), reaction parameters such the amount of catalyst, hydrogen peroxide, and duration were improved. Furthermore, without experiencing a discernible loss of reactivity in the sulfide oxidation reaction, the catalysts were effortlessly magnetically retrieved and may be employed repeatedly.
Construction of a CRISPR‐Cas9‐Based Genetic Editing Tool for Serratia marcescens Using a Stationary Phase Promoter and Its Application in Putrescine Production
Authors: Gou Linbo , Liu Di , Fan Tai‐Ping , Deng Huaxiang , Cai Yujie 
Published: February 2025

ABSTRACTPutrescine plays a significant role in green food production and agriculture by promoting plant growth and enhancing crop quality. Its application reduces the reliance on chemical fertilizers and pesticides, thereby supporting the advancement of sustainable agricultural practices. This study achieved efficient production of putrescine in Serratia marcescens. S. marcescens has been extensively used to synthesize antimicrobial substances and express proteins, but its application has been limited by the lack of efficient genome‐editing tools. This study presents a CRISPR‐Cas9‐based tool for gene editing in S. marcescens. A dual‐plasmid system was constructed, incorporating an editing template into the plasmid pEdit with target‐specific sgRNA. A stationary phase promoter was used to express Cas9 from Streptococcus pyogenes protein, avoiding the need for additional inducers and ensuring efficient one‐step gene knockout and integration. The tool demonstrated over 80% editing efficiency across various S. marcescens strains and enabled successful single‐base mutations. Using this tool, we enhanced putrescine production in S. marcescens HBQA7, optimizing the expression of ornithine decarboxylase from Clostridium aceticum DSM1496 with the P2 promoter and identifying the optimal integration site. Putrescine production reached 8.46 g/L within 48 h. This study significantly advances S. marcescens gene editing and metabolic engineering.
Pathways to Circularity: Engagement Patterns of European SMEs in the Circular Economy
Authors: Lopes João M. , Gomes Sofia , Nogueira Elisabete 
Published: February 2025

ABSTRACTCompliance with the 2030 agenda is forcing small and medium‐sized enterprises (SMEs) in the European Union (EU) to transition from linear to circular business models, boosting the adoption of circular economy (CE) activities. More information is needed to know the transition stage of these companies. Therefore, the objective of this study is to evaluate the implementation patterns of nine CE activities by EU SMEs and explore the relationships between the implementation of CE activities and the characteristics of these companies in terms of economic activity and ownership. To this end, we used a sample of 13,322 SMEs from the EU, using the Latent Class Model to identify the implementation patterns of CE activities and correspondence analysis to relate the implementation of CE activities with the characteristics of the SMEs. The results show that in the implementation of CE activities, five patterns of SMEs involvement can be identified, with CE activities being systematically independent in each pattern. It was also demonstrated that the SMEs with the highest probability of engagement are those dedicated to service activities, medium‐sized companies established more years ago, with high and growing turnover, which invest most of their turnover annually in CE activities, and those that sell products or services to multiple final destinations. This study contributes to demonstrating that the essential dynamic capabilities of SMEs to become circular must be incorporated into a pattern of implementation of CE activities and that in their implementation, CE activities are not independent of each other but follow a specific pattern of involvement, in which activities are invariably interdependent in relation to other patterns.
How Can Religion Shape Pro‐Environmental Behavior in a Materialistic World? Contrasting Idealism With Realism Religious Epics
Authors: Das Manish , Lim Weng Marc , Paul Subhrajit , Roy Abhirupa , Purohit Sonal 
Published: February 2025

ABSTRACTDespite extensive research on the influence of religion on pro‐environmental behavior, little attention has been paid to the role of religious epics—that is, narratives that embody the core beliefs and moral values of religious traditions—as a mechanism for promoting such behavior. Using Hinduism as a case, this research seeks to bridge this gap by contrasting the orientations of idealism in the Ramayana with realism in the Mahabharata, offering a better understanding of how these distinct orientations in religious epics can shape pro‐environmental behavior. Utilizing belief congruence theory as a theoretical framework, this four‐study research examines altruism as a mediator and materialism as a moderator in understanding the role of religious epics in shaping pro‐environmental behavior. The findings suggest that the idealistic orientation of the Ramayana fosters stronger pro‐environmental behavior through heightened altruistic values, whereas the realistic orientation of the Mahabharata shows a less pronounced effect, which is further attenuated by materialism. These insights not only contribute to the theoretical discourse on consumer behavior, ethics, religion, and sustainability, but also offer practical implications for leveraging religious epics in fostering pro‐environmental behavior in a materialistic world.
AKR1B1 Inhibits Ferroptosis and Promotes Gastric Cancer Progression via Interacting With STAT3 to Activate SLC7A11
Authors: Yang Kaiyan , Zhang Xin , Long Fei , Dai Jing 
Published: February 2025

ABSTRACTGastric cancer (GC) is a frequently diagnosed malignant tumor in clinical settings; however, the mechanisms underlying its tumorigenesis remain inadequately understood. In this study, we identified significantly elevated expression levels of AKR1B1 in GC tissues through quantitative polymerase chain reaction (qPCR) and western blotting assays. Furthermore, a negative correlation was established between patient survival probability and AKR1B1 expression levels. Functionally, our experiments, including colony formation, transwell migration, and xenograft assays, demonstrated that the depletion of AKR1B1 inhibited the proliferation and progression of GC cells both in vivo and in vitro. Additionally, the assessment of reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), and mitochondrial morphology confirmed that AKR1B1 depletion induces ferroptosis. Mechanistically, we found that AKR1B1 interacts with STAT3, which subsequently activates SLC7A11. Notably, the ferroptosis induced by AKR1B1 depletion could be reversed by the overexpression of SLC7A11, thereby substantiating these interactions. In conclusion, our findings identify AKR1B1 as a novel oncogene in GC and elucidate the mechanism involving the AKR1B1‐STAT3‐SLC7A11 pathway and ferroptosis, providing new insights for potential therapeutic strategies in the treatment of GC.
Electronic Interactions in Coulombic Associated Photoactive Macrocycles to Chemically Modified MoS2 Nanosheets
Authors: Tsigkou Marina , Nikoli Eleni , Sideri Ioanna K. , Kardaras Michalis , Galvan Hiram Joazet Ojeda , Quintana Mildred , Tagmatarchis Nikos 
Published: February 2025

AbstractWhilst functionalization of transition metal dichalcogenides (TMDs), and more specifically MoS2, has flourished the past decade, the accommodation of photoactive molecules on their lattice has unlocked the potentiality of this family of materials in a series of optoelectronic and energy related applications. The electronic communication between the chromophore and MoS2, in such systems, has been thoroughly studied, in cases where the grafting of the former on the latter is secured through covalent bonding. However, comparatively less attention has been drawn in cases where the chromophore is electrostatically anchored on MoS2, a means that potentially provides alternative ways of spatially accommodating the ligand on the TMD's extended environment, which directly affects the electronic communication between the two entities. In this work, we comparatively study the photophysical characteristics of three separate nanoensembles, where MoS2 is electrostatically hosting a Zn‐phthalocyanine, a Zn‐porphyrin, and a boron‐dipyrromethene, that complementary cover a wide range of visible absorption, via UV‐Vis and photoluminescence spectroscopy. The results highlight the strong interactions in the excited state across all chromophores, while the ground‐state interactions vary from chromophore to chromophore, indicating a distinct energy exchange dependent on the specific nanoensemble.