bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the unpredictable nature of climate policy uncertainty: An empirical analysis of its impact on commodity futures returns in the United States
Authors: Tang Chia‐Hsien , Lee Yen‐Hsien , Liu Hung‐Chun , Zeng Guan‐Gzhe 
Published: April 2024

AbstractThis study offers a nuanced examination of the interplay between climate policy uncertainty (CPU) and three categories of the US commodity futures returns (metals, energy, and soft commodities). By integrating a regression framework with a Markov regime‐switching approach, our results uncover both linear and nonlinear effects of CPU in varying volatility contexts. This comprehensive methodological approach sheds light on CPU's diverse impacts across various types of commodity futures. The findings illustrate CPU's notable influence on metal and energy futures in low‐volatility regime, contrasted with its more pronounced effect on soft commodities during high‐volatility regime. These insights are pivotal for investors strategizing in light of CPU, and underscore the significance of renewable energy in alleviating climate policy uncertainties within commodity markets.
Heterogeneous characterization of neutrophilic cells in head and neck cancers
Authors: Fay Magdalena , Clavijo Paul E. , Allen Clint T. 
Published: April 2024

AbstractBackgroundNeutrophilic cells are among the most abundant immune populations within the head and neck tumor microenvironment (TME) and harbor multiple mechanisms of immunosuppression. Despite these important features, neutrophilic cells may be underrepresented in contemporary studies that aim to comprehensively characterize the immune landscape of the TME due to discrepancies in tissue processing and analysis techniques. Here, we review the role of pathologically activated neutrophilic cells within the TME and pitfalls of various approaches used to study their frequency and function in clinical samples.MethodsThe literature was identified by searching PubMed for “immune landscape” and “tumor immune microenvironment” in combination with keywords describing solid tumor malignancies. Key publications that assessed the immune composition of solid tumors derived from human specimens were included. The tumor and blood processing methodologies in each study were reviewed in depth and correlated with the reported abundance of neutrophilic cells.ResultsNeutrophilic cells do not survive cryopreservation, and many studies fail to identify and study neutrophilic cell populations due to cryopreservation of clinical samples for practical reasons. Additional single‐cell transcriptomic studies filter out neutrophilic cells due to low transcriptional counts.ConclusionsThis report can help readers critically interpret studies aiming to comprehensively study the immune TME that fail to identify and characterize neutrophilic cells.
Beyond basics: Key mutation selection features for successful tumor‐informed ctDNA detection
Authors: Nesic Marijana , Rasmussen Mads H. , Henriksen Tenna V. , Demuth Christina , Frydendahl Amanda , Nordentoft Iver , Dyrskjøt Lars , Andersen Claus L. 
Published: April 2024

AbstractTumor‐informed mutation‐based approaches are frequently used for detection of circulating tumor DNA (ctDNA). Not all mutations make equally effective ctDNA markers. The objective was to explore if prioritizing mutations using mutational features—such as cancer cell fraction (CCF), multiplicity, and error rate—would improve the success rate of tumor‐informed ctDNA analysis. Additionally, we aimed to develop a practical and easily implementable analysis pipeline for identifying and prioritizing candidate mutations from whole‐exome sequencing (WES) data. We analyzed WES and ctDNA data from three tumor‐informed ctDNA studies, one on bladder cancer (Cohort A) and two on colorectal cancer (Cohorts I and N). The studies included 390 patients. For each patient, a unique set of mutations (median mutations/patient: 6, interquartile 13, range: 1–46, total n = 4023) were used as markers of ctDNA. The tool PureCN was used to assess the CCF and multiplicity of each mutation. High‐CCF mutations were detected more frequently than low‐CCF mutations (Cohort A: odds ratio [OR] 20.6, 95% confidence interval [CI] 5.72–173, p = 1.73e−12; Cohort I: OR 2.24, 95% CI 1.44–3.52, p = 1.66e−04; and Cohort N: OR 1.78, 95% CI 1.14–2.79, p = 7.86e−03). The detection‐likelihood was additionally improved by selecting mutations with multiplicity of two or above (Cohort A: OR 1.55, 95% CI 1. 14–2.11, p = 3.85e−03; Cohort I: OR 1.78, 95% CI 1.23–2.56, p = 1.34e−03; and Cohort N: OR 1.94, 95% CI 1.63–2.31, p = 2.83e−14). Furthermore, selecting the mutations for which the ctDNA detection method had the lowest error rates, additionally improved the detection‐likelihood, particularly evident when plasma cell‐free DNA tumor fractions were below 0.1% (p = 2.1e−07). Selecting mutational markers with high CCF, high multiplicity, and low error rate significantly improve ctDNA detection likelihood. We provide free access to the analysis pipeline enabling others to perform qualified prioritization of mutations for tumor‐informed ctDNA analysis.
Cumulative live birth rates following intrauterine insemination using donor and husband sperm in different age groups: A cohort study of 10 415 insemination cycles
Authors: Zhang Dian , Cai He , Xie Jinlin , Chen Lijuan , Zhang Zhou , Shi Juanzi 
Published: April 2024

AbstractObjectivesTo assess the age‐specific cumulative live birth rates (CLBRs) in intrauterine insemination (IUI) cycles using either donor or husband sperm, and to investigate the impact of sperm sources on IUI success among women within the same age group.MethodsThis retrospective cohort study comprised women who underwent IUI with donor sperm (IUI‐D) or husband sperm (IUI‐H) from 2017 to 2021. The women were stratified based on their age at the initiation of insemination into four categories: <35, 35–37, 38–39 and ≥40 years.ResultsA total of 5253 women undergoing 10 415 insemination cycles (3354 with IUI‐D and 7061 with IUI‐H) were included. The CLBRs decreased significantly with increasing maternal age within donor and husband insemination groups (P < 0.001). In the IUI‐D group, the crude CLBRs were 61.50% in women aged <35, 48.91% in 35–37, 24.14% in 38–39 and 11.76% in the ≥40‐year age category, respectively. The corresponding rates in the IUI‐H group were 27.62%, 22.96%, 13.73% and 6.90%, respectively. Within the <35 and 35–37‐year age categories, the CLBRs were significantly higher following IUI‐D cycles compared to IUI‐H cycles, with hazard ratios (HR) of 1.85 (1.68–2.04) and 1.69 (1.16–2.47), respectively. However, within the 38–39 and ≥40‐year age categories, both IUI‐D and IUI‐H resulted in comparable low CLBRs, with HRs of 1.91 (0.77–4.76) and 1.80 (0.33–9.86), respectively.ConclusionAdvanced maternal age affects the whole process of fertility. Therefore, it could be reasonable to limit the number of IUI performed in women aged 40 years and older, even in couple using donor sperm for reproduction.
Digital transformation of warungs in Indonesia: The interrelation of socio‐technical and indigenous factors
Authors: ER Mahendrawathi , Muhammad Ghifary , Ramadhany Emha Diambang , Nurkasanah Ika 
Published: April 2024

AbstractWe investigate the moderating effect of an indigenous Indonesian concept, kekeluargaan (kinship ties and obligations), on the digital transformation (DT) of the warung, a traditional family microbusiness in Indonesia. Our study is structured as a multi‐case study: we assessed how five warungs, to varying degrees, engaged in DT. Socio‐technical systems theory guides the data collection via semi‐structured interviews and observations. The data is analyzed through codification to look for themes and patterns from the multiple units of analysis. The findings show that the growth mindset of warung owners influences how they solve business problems, ensure operational efficiency, and increase profit. Some create an effective structure in operating their warung by working with their family members. Owners with a high technology mindset successfully learn and adapt the technology. We theorize that kekeluargaan plays a moderating role for the owner where technology‐related tasks are concerned. We found that when kekeluargaan is present, it positively moderates the owner's engagement in technology‐related tasks. However, when kekeluargaan is absent, the moderating effect is low. The findings extend the literature on DT for microbusinesses with indigenous cultural factors that should be considered to successfully transform a traditional business.
An explicit construction for large sets of infinite dimensional q $q$‐Steiner systems
Authors: Hawtin Daniel R. 
Published: April 2024

AbstractLet be a vector space over the finite field . A ‐Steiner system, or an , is a collection of ‐dimensional subspaces of such that every ‐dimensional subspace of is contained in a unique element of . A large set of ‐Steiner systems, or an , is a partition of the ‐dimensional subspaces of into systems. In the case that has infinite dimension, the existence of an for all finite with was shown abstractly by Cameron in 1995. This paper provides an explicit construction of an for all prime powers , all positive integers , and where has countably infinite dimension.
Multimodal ultrasound diagnosis of epididymo‐orchitis with secondary testicular infarction: A case report
Authors: Liu Yuexia , Shu Shengchun , Shi Jiayao , Li Jinbing 
Published: April 2024

AbstractWe report a case of a 48‐year‐old man with testicular infarction caused by epididymo‐orchitis (EO). Multimodal ultrasound showed extensive necrosis of the testis, and the patient underwent right orchiectomy. Postoperative pathology confirmed extensive necrosis of the testis. After 3 months of follow‐up, the examination of scrotal ultrasound showed that the left testis and epididymis had no obvious abnormality.
Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Authors: Bado Patricia P. , Salum Giovanni A. , Rohde Luis A. , Gadelha Ary , Pan Pedro M. , Miguel Eurípedes C. , Tripp Gail , Furukawa Emi 
Published: April 2024

AbstractBackgroundA stronger preference for immediate rewards has been reported in individuals with ADHD and other disorders. However, the consistency of the associations between this preference and psychiatric conditions as well as functional outcomes have been questioned. Research on its association with longitudinal outcomes is scarce.MethodsThe current study used data on a choice delay task (CDT) from a school‐based cohort of Brazilian children with those at higher risk for psychiatric disorders over‐sampled (n = 1917). The sample included typically developing children (n = 1379), those with ADHD (n = 213), and other disorders. The frequency of the trials where children chose a larger later reward versus a smaller sooner reward was compared for those with ADHD and typically developing children. Cross‐sectionally and longitudinally, the study also evaluated whether children's preference for larger delayed rewards at baseline predicted the presence of psychiatric disorders and functional life outcomes (academic performance, alcohol use, early pregnancy, criminal conviction, BMI).ResultsChildren with ADHD and their typically developing peers performed similarly on the CDT. Their baseline task performance was not related to psychiatric conditions or life outcomes.ConclusionsThe current results raise questions regarding the use of the CDT with diverse populations and whether a preference for larger delayed rewards is predictive of positive long‐term outcomes as widely assumed.
Value of quantitative microsurface structure analysis for evaluating the invasion depth of type 0–II early gastric cancer
Authors: Jiang Zhang‐Xiu , Liang Yun‐Xiao , Huang Peng‐Yu , Ning Jia‐Juan , Qi Jing‐Jing 
Published: April 2024

AbstractBackground and AimThe microsurface structure reflects the degree of damage to the glands, which is related to the invasion depth of early gastric cancer. To evaluate the diagnostic value of quantitative microsurface structure analysis for estimating the invasion depth of early gastric cancer.MethodsWhite‐light imaging and narrow‐band imaging (NBI) endoscopy were used to visualize the lesions of the included patients. The area ratio and depth‐predicting score (DPS) of each patient were calculated; meanwhile, each lesion was examined by endoscopic ultrasonography (EUS).ResultsNinety‐three patients were included between 2016 and 2019. Microsurface structure is related to the histological differentiation and progression of early gastric cancer. The receiver operating characteristic curve showed that when an area ratio of 80.3% was used as a cut‐off value for distinguishing mucosal (M) and submucosal (SM) type 0–II gastric cancers, the sensitivity, specificity, and accuracy were 82.9%, 80.2%, and 91.6%, respectively. The accuracies for distinguishing M/SM differentiated and undifferentiated early gastric cancers were 87.4% and 84.8%, respectively. The accuracy of EUS for distinguishing M/SM early gastric cancer was 74.9%. DPS can only distinguish M‐SM1 (SM infiltration <500 μm)/SM (SM infiltration ≥500 μm) with an accuracy of 83.8%. The accuracy of using area ratio for distinguishing 0–II early gastric cancers was better than those of using DPS and EUS (P < 0.05).ConclusionQuantitative analysis of microsurface structure can be performed to assess M/SM type 0–II gastric cancer and is expected to be effective for judging the invasion depth of gastric cancer.
Transitional care clinics for patients discharged from hospital without a primary care provider: A systematic review
Authors: Dmitriew Cait , Houle Del J. , Filipovic Michelle , Chochla Ella , Hemy Alexander , Woods Celeste , Farhat Nawal , Campbell Alanna , Liu Lisa J. W. , Cragg Jacquelyn J. , Crispo James A. G. 
Published: April 2024

AbstractBackgroundThe transition from hospital to home is a high‐risk period. Timely follow‐up care is essential to reducing avoidable harms such as adverse drug events, yet may be unattainable for patients who lack attachment to a primary care provider. Transitional care clinics (TCCs) have been proposed as a measure to improve health outcomes for patients discharged from hospital without an established provider. In this systematic review, we compared outcomes for unattached patients seen in TCCs after hospital discharge relative to care as usual.MethodsWe searched the following bibliographic databases for articles published on or before August 12, 2022: MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Cochrane Database of Systematic Reviews, PsycINFO, and Web of Science. Five studies were identified that examined the effects of a dedicated postdischarge clinic on emergency department (ED) visits, readmissions, and/or mortality within 90 days of discharge for patients with no attachment to a primary care provider.ResultsStudies were heterogeneous in design and quality; all were from urban centers within the United States. Four of the five studies reported a reduction in either the number of ED visits or readmissions in patients seen in a TCC following hospitalization.ConclusionsTCCs may be effective in reducing hospital contacts in the period following hospital discharge in patients with no established primary care provider. Further studies are required to evaluate the health benefits attributable to the implementation of TCCs across a broad range of practice contexts, as well as the cost implications of this model.
Early diagnosis and treatment by newborn screening (NBS) or family history is associated with improved visual outcomes for long‐chain 3‐hydroxyacylCoA dehydrogenase deficiency (LCHADD) chorioretinopathy
Authors: Gillingham Melanie B. , Choi Dongseok , Gregor Ashley , Wongchaisuwat Nida , Black Danielle , Scanga Hannah L. , Nischal Ken K. , Sahel Jose‐Alain , Arnold Georgianne , Vockley Jerry , Harding Cary O. , Pennesi Mark E. 
Published: April 2024

AbstractLong chain 3‐hydroxyacyl‐CoA dehydrogenase (LCHADD) is the only fatty acid oxidation disorder to develop a progressive chorioretinopathy resulting in vision loss; newborn screening (NBS) for this disorder began in the United States around 2004. We compared visual outcomes among 40 participants with LCHADD or trifunctional protein deficiency diagnosed symptomatically to those who were diagnosed via NBS or a family history. Participants completed ophthalmologic testing including measures of visual acuity, electroretinograms (ERG), fundal imaging, contrast sensitivity, and visual fields. Records were reviewed to document medical and treatment history. Twelve participants presented symptomatically with hypoglycemia, failure to thrive, liver dysfunction, cardiac arrest, or rhabdomyolysis. Twenty eight were diagnosed by NBS or due to a family history of LCHADD. Participants diagnosed symptomatically were older but had similar percent males and genotypes as those diagnosed by NBS. Treatment consisted of fasting avoidance, dietary long‐chain fat restriction, MCT, C7, and/or carnitine supplementation. Visual acuity, rod‐ and cone‐driven amplitudes on ERG, contrast sensitivity scores, and visual fields were all significantly worse among participants diagnosed symptomatically compared to NBS. In mixed‐effects models, both age and presentation (symptomatic vs. NBS) were significant independent factors associated with visual outcomes. This suggests that visual outcomes were improved by NBS, but there was still lower visual function with advancing age in both groups. Early diagnosis and treatment by NBS is associated with improved visual outcomes and retinal function compared to participants who presented symptomatically. Despite the impact of early intervention, chorioretinopathy was greater with advancing age, highlighting the need for novel treatments.
Long‐term personalized high‐protein, high‐fat diet in pediatric patients with glycogen storage disease type IIIa: Evaluation of myopathy, metabolic control, physical activity, growth, and dietary compliance
Authors: Kalkan Uçar Sema , Altınok Yasemin Atik , Mansuroglu Yelda , Canda Ebru , Yazıcı Havva , Çelik Merve Yoldaş , Erdem Fehime , Yanbolu Ayşe Yüksel , Ülger Zülal , Çoker Mahmut 
Published: April 2024

AbstractDietary lipid manipulation has recently been proposed for managing glycogen storage disease (GSD) type IIIa. This study aimed to evaluate the myopathic, cardiac, and metabolic status, physical activity, growth, and dietary compliance of a personalized diet high in protein and fat for 24 months. Of 31 patients with type IIIa GSD, 12 met the inclusion criteria. Of these, 10 patients (mean age 11.2 ± 7.4 years) completed the study. Patients were prescribed a personalized high‐protein, high‐fat diet, comprising 3.0–3.5 g/kg/day of protein and 3.0–4.5 g/kg/day of fat, constituting 18.5%–28% and 70.5%–75.7% of daily energy, respectively. Dietary compliance was ensured and assessed via the regular administration of questionnaires. Our results revealed consistent and significant decreases of 22%, 54%, and 30% in the creatinine kinase, creatine kinase–myocardial band, and lactate dehydrogenase levels, respectively. Echocardiography revealed improvements in the Z‐scores of the left ventricular mass and interventricular septum thickness. A significant increase in body muscle mass was observed, and a higher score was achieved using the Daily Activity Questionnaire. Growth monitoring revealed an arrest in the height‐SDS at the 6th and 12th months, followed by subsequent improvement at the end of the second year. A gradual and persistent decline in the periods of hypo‐ and hyperglycemia has been reported. Biotinidase activity decreased, whereas hepatosteatosis increased and then decreased by the end of the study. Implementing a high‐protein, high‐fat diet and monitoring key parameters in patients with type IIIa GSD can lead to myopathic and cardiac improvements and increased physical activity.
Naturally developed HPV16 antibodies and risk of newly detected cervical HPV infection outcomes
Authors: Trevisan Andrea , Candeias João M. G. , Thomann Patrícia , Villa Luisa L. , Franco Eduardo L. , Trottier Helen 
Published: April 2024

AbstractLittle is known about the protection conferred by antibodies from natural human papillomavirus (HPV) infection. Our objective was to evaluate the association between HPV16 seroreactivity and HPV16 redetection, newly detected HPV infections, and loss of HPV DNA detection during follow‐up. We analyzed data from 2462 unvaccinated Brazilian women. HPV16 IgG and neutralizing antibodies at baseline were assessed by enzyme‐linked immunosorbent assay (n = 1975) and by the pseudovirus‐based papillomavirus neutralization assay (n = 487). HPV detection, genotyping, and viral load were assessed by PCR‐based methods. The associations were analyzed by Cox proportional hazards models. We observed a positive association between HPV16 IgG seroreactivity and redetection of HPV16 infections. Age‐adjusted hazard ratios (HR) with 95% confidence intervals (CI) ranged from 2.45 (1.04–5.74) to 5.10 (1.37–19.00). Positive associations were also observed between HPV16 IgG antibodies and (1) newly detected HPV infections by genotypes unrelated to HPV16 (age‐adjusted HR [95% CI] = 1.32 [1.08–1.2]) and (2) loss of detection of HPV infections by genotypes unrelated to HPV16 (age‐adjusted HR [95% CI] = 1.24 [1.03–1.50]). Naturally developed HPV16 antibodies do not prevent recurrent HPV infections. Overall HPV16 IgG and neutralizing antibodies seem to be serological markers for latent or past infections.
Neural correlates of metacognition: Disentangling the brain circuits underlying prospective and retrospective second‐order judgments through noninvasive brain stimulation
Authors: Saccenti Daniele , Moro Andrea Stefano , Sassaroli Sandra , Malgaroli Antonio , Ferro Mattia , Lamanna Jacopo 
Published: April 2024

AbstractMetacognition encompasses the capability to monitor and control one's cognitive processes, with metamemory and metadecision configuring among the most studied higher order functions. Although imaging experiments evaluated the role of disparate brain regions, neural substrates of metacognitive judgments remain undetermined. The aim of this systematic review is to summarize and discuss the available evidence concerning the neural bases of metacognition which has been collected by assessing the effects of noninvasive brain stimulation (NIBS) on human subjects' metacognitive capacities. Based on such literature analysis, our goal is, at first, to verify whether prospective and retrospective second‐order judgments are localized within separate brain circuits and, subsequently, to provide compelling clues useful for identifying new targets for future NIBS studies. The search was conducted following the preferred reporting items for systematic reviews and meta‐analyses guidelines among PubMed, PsycINFO, PsycARTICLES, PSYNDEX, MEDLINE, and ERIC databases. Overall, 25 studies met the eligibility criteria, yielding a total of 36 experiments employing transcranial magnetic stimulation and 16 ones making use of transcranial electrical stimulation techniques, including transcranial direct current stimulation and transcranial alternating current stimulation. Importantly, we found that both perspective and retrospective judgments about both memory and perceptual decision‐making performances depend on the activation of the anterior and lateral portions of the prefrontal cortex, as well as on the activity of more caudal regions such as the premotor cortex and the precuneus. Combining this evidence with results from previous imaging and lesion studies, we advance ventromedial prefrontal cortex as a promising target for future NIBS studies.