bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of biomimetic nanohydroxyapatite on remineralisation of carious lesion: A systematic review
Authors: Shelke Snehal Babasaheb , Warhadpande Manjusha M , Dakshindas Darshan M , Radke Sulabha A 
Published: March 2024

Dental caries is a prevalent infectious disease of the dental hard tissue. Simple non-invasive remineralization of dental caries may be sufficient to stop the progression of incipient carious lesions. Research question was formulated based on the PICO strategy. A comprehensive electronic literature search was conducted, independently by two reviewers. Based on the specified inclusion and exclusion criteria, the selected articles were subjected to quality assessment and the risk of bias evaluation was done.The objective of this study was to conduct a systematic review of the literature on effectiveness of nanohydroxyapatite on remineralization of caries in comparison with other conventional remineralizing agents.A search was performed in electronic database (i.e. PubMed, Cochrane and google scholar) using search terms alone and in combination by means of PubMed search builder from January 2010 to January 2023. Studies were selected if they met the following criteria: randomized clinical trials comparing nanohydroxyapatite and other remineralizing agents for caries remineralization. Nanohydroxyapatite has comparable efficacy on remineralization of dental caries. Biomimetic hydroxyapatite-containing, fluoride-free oral care products are effective in remineralization of dental caries, especially in children. Additional long-term studies employing standardized protocols are necessary to draw definitive findings about the effect of hydroxyapatite on remineralization of dental caries. Nano-hydroxyapatite is a biomimetic and have a remineralizing effect on early carious lesions.
Comparative evaluation of the efficacy of various irrigating techniques by checking the depth of penetration of the sealer- An in-vitro study
Authors: Chikara Shivani , Asthana Garima , Chand Jyoti 
Published: March 2024

Sonic irrigant activation has gained widespread popularity among general dentists and endodontists currently. It is usually seen that sonic powered flosser which we have used in our study is in use in many dental colleges by post graduate students as it is construed to be the cheaper version of Endoactivator.To investigate the efficacy of sonic powered flosser with various irrigating techniques by checking the depth of sealer penetration. Forty five single-rooted teeth were instrumented and divided into 3 groups of 15 teeth each, as Group 1: endoactivator; Group 2: powered sonic flosser; Group 3: manual dynamic irrigation. The samples were obturated with AH Plus sealer labelled with Rhodamine B dye. The teeth were sectioned and viewed under confocal microscope to determine the depth of sealer penetration.Statistical analysis used: One way Anova F test was used for overall comparison among three groups and Tukey's post hoc test were used to evaluate the efficiency levels between groups. P value less than 0.05 was considered significant for all statistical test. The results showed that the maximum penetration was exhibited by endoactivator followed by manual dynamic irrigation and least by powered sonic flosser. The middle third showed the maximum penetration, followed by apical third in all the groups. Sonic powered flosser and manual agitation weren’t found to be as effective as Endoactivator, so in the absence of Endoactivator, sonic and manual agitation can’t be relied upon for desired results. The agitation of the irrigants is found to be most effective with endoactivator in order to achieve appreciable sealer penetration.So using sonic powered flosser will not be able to render the results as good as endoactivator.
An invitro comparison of antimicrobial efficacy of sodium hypochlorite gel with twin kleen irrigating solution against enterococcus feacalis
Authors: Mirza Mohammed Suhail , Uppin Veerendra M , Pujar Madhu , Gopeshetti Pallavi , Umesh Sahana 
Published: March 2024

The Enterococcus faecalis (E. faecalis) is a normal inhabitant of the oral cavity and is the most commonly identified species in post treatment asymptomatic persistent endodontic diseases (both intra-radicular and extra- radicular). Its prevalence ranges from 24% to 77%. To completely eliminate microorganisms from the root canal system, combination of instrumentation and irrigation with antibacterial solutions is necessary. Hence, the purpose of this study was to evaluate and compare the antibacterial efficacy of sodium hypochlorite gel with twin kleen irrigating solution against E. faecalis.40 non-carious, single-rooted teeth with straight canals were selected and instrumented till F3 (30.06) ProTaper Universal (Dentsply Maillefer, Ballaigues, Switzerland). E faecalis was prepared and incubated in teeth and were randomly divided into four groups of 10 each, Group A – 5.25% NaOCl gel, Group B – Twin Kleen Irrigating solution, Group C – 3% NaOCl solution and Group D – Saline. Sterile paper points were used to collect the samples after irrigation and then they were transferred to blood agar culture plates to check the presence of E. faecalis. Significant statistical difference was seen between the four groups. The effect of 5.25% NaOCl gel was superior as compared to Twin Kleen irrigating solution.Under the limitations of this study, 5.25% NaOCl gel was effective in reducing E. faecalis count followed by Twin kleen irrigating solutions.
GESTÃO TECNOLÓGICA EM SAÚDE: a contribuição das healthechs para superação das limitações
Authors: Gomes do Espirito Santo Renato , Kinast de Camillis Patricia 
Published: March 2024

Reconhecendo a importância e rápida ascensão das healthtechs, este artigo traz as fundamentações e resultados do levantamento das dificuldades encontradas pelos gestores em saúde, para implementar a inovação tecnológica no setor. Para tanto, a coleta, o tratamento, descrição e problematização dos dados foram feitas através da pesquisa qualitativa exploratória, realizada com entrevistas semiestruturadas e análise de conteúdo. A fim de ter um panorama mais próximo da realidade da gestão em saúde, foram abordados 6 (seis) Chief Executive Officer de healthtechs, os quais foram submetidos à dezessete questões subjetivas. O objetivo principal foi, por conseguinte, analisar essas dificuldades, no que tange à inovação tecnológica para essas startups, a partir da perspectiva dos entrevistados. Como principais resultados, foram observadas dificuldades técnicas para a operacionalização, como conservadorismo do setor, etc.; entraves jurídicos para a implementação, tratados como uma burocracia necessária, porque confere segurança e proteção de dados ao paciente/cliente, e dificuldades na Cultura Organizacional, que reúnem a ausência de lideranças, planejamento estratégico e a limitação orçamentária. Por fim, concluiu-se a urgência em se investir em formação complementar, treinamento, aquisição de equipamentos e aprimorar osconhecimentos em liderança, gestão, governança e inovação.
Palavras-chave: Healthtechs. Gestão em Saúde. Inovação Tecnológica em Saúde.
Pengaruh Komposisi Media Tanam dan Larutan Nutrisi Terhadap Pertumbuhan dan Hasil Sawi Pagoda (Brassicaee Narinosa L.) pada Sistem Hidroponik Substrat
Authors: Fachryansyah Moh , Soeparjono Sigit 
Published: March 2024

Sawi pagoda adalah jenis sayuran yang berasal dari tiongkok, cina. Sawi pagoda merupakan salah satu jenis sawi yang berkerabat dekat dengan pakcoy (Brassica rapa subs. Chinensis). Kebutuhan sawi juga terus meningkat seiring dengan pertumbuhan jumlah penduduk. Upaya yang dapat dilakukan dengan membudidayakan menggunakan teknik hidroponik substrat dengan komposisi media yang tepat dan penambahan larutan nutrisi. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi komposisi media tanam dengan larutan nutrisi terhadap pertumbuhan dan hasil tanaman sawi pagoda bertempat di Jl. Kaliurang Gg. Swadaya 3 No. 7 Sumbersari Jember pada bulan Agustus sampai September 2023. Penelitian ini dirancang menggunakan Rancangan Acak Kelompok (RAK) dengan dua faktor perlakuan dengan 3 kali ulangan. Faktor pertama 4 taraf komposisi media, faktor kedua 4 taraf komposisi larutan nutrisi, sehingga jumlah keseluruhan tanaman yang digunakan adalah 48 tanaman. Data yang telah diperoleh dianalisis menggunakan ANOVA dan apabila terdapat pengaruh perlakuan yang berbeda nyata atau sangat nyata maka dilakukan uji lanjut dengan menggunakan uji Duncan DMRT pada taraf 95%. Berdasarkan hasil penelitian menunjukkan bahwa pemberian media tanam dan larutan nutrisi berpengaruh nyata pada variabel terhadap diameter tajuk, berat basah akar dan klorofil daun, sedangkan faktor tunggal perlakuan media berpengaruh nyata pada pada berat basah akar, berat kering akar dan klorofil daun. Pada faktor tunggal perlakuan air kelapa berpengaruh nyata pada variabel diameter tajuk daun, jumlah daun, berat basah akar dan berat kering akar.
Exploring Listening Relationship Pattern of Information Approval Process in Science Learning: A Qualitative Investigation Using TBLA (Transcript Based Lesson Analysis)
Authors: Hajar Maya Umi , Putra Dedy Dwi 
Published: March 2024

<p dir="ltr"><span>This study reveals listening relationship patterns in the information approval process used to improve the quality of learning dialogue, especially in science learning. A qualitative method with a case study approach was used to analyze listening relationship patterns in science learning during one semester. A total of 3 science teachers, 31 students, and two academics involved in lesson study for learning communities were selected to capture a mutual listening relationship pattern in receiving information with a natural performance and not tense when observing. Observation, documentation, and clinical interviews were used as data collection techniques. Video and audio recorders were involved as documentation tools for this study. Transcript-based lesson analysis (TBLA) was included in conducting data analysis. The listening relationship patterns analysis results in classical discussion sessions in cycles 1–3, which tend to have semi-equal listening relationship patterns. Meanwhile, the listening relationship pattern in group discussion sessions in cycles 1 to 3 tends to be the isolated listening relationship group pattern. The shift in the pattern of listening relationships in group discussion sessions is caused by several factors, including student collaboration awareness, heterogeneous composition of students, tasks, and questions that challenge students, and appropriate interruptions of teacher direction. The research results provide a reference for reflection on developing teacher professionalism to improve more effective and meaningful learning.</span></p><div><span><br /></span></div>
Use Of The Yamaha F100B Outboard Engine As a Populsion On The Rinca and Bawean Survey Boats
Authors: Aldiantofas Rizky Dwi , Akbar Ali 
Published: March 2024

The aim of this research is to determine the use of the Yamaha F100B outboard engine as a propulsion for the Rinca and Bawean survey boats. The research was carried out within one month, namely August to September 2023. This research was carried out using practical field work methods. The variables in this research were the specification,work process, fuel efficiency system, superiority, and environmental impact. The method in this research uses the observation method, namely the method of collecting data by recording directly while in the field. The research results show that the use of a Yamaha F100B outboard motor as a propulsion is able to provide adequate thrust for the survey vessel, with efficient fuel consumption. In the context of survey vessels, the reliability and speed of these motors are important factors in supporting successful marine survey operations.
TRIM37 maintains 5hmC levels and stemness through preventing DNMT1 alternative splicing
Authors: HUNG SHIH-CHIEH , Ho Chun-Te , Li Ling-Hui , Chang Wei-Chao , Wu Heng-Hsiung , Chen Ya-Huey 
Published: March 2024

Abstract
The significance of DNA hydroxymethylation in stemness remains unknown. Here, we demonstrate 5hmC levels positively regulate mesenchymal stem cell (MSC) properties. Mechanistically, PARP1 recruits TET1 to hydrolyze methylated nucleotides on DNMT1 exons, helping CTCF to bind to exons and prevent DNMT1 alternative splicing in early MSCs. Furthermore, ATM phosphorylates TRIM37 at Th203 and promotes its entry into the nucleus, as well as the monoubiquitination of PARP1, thereby stabilizing the PARP1 protein. CTCF or TRIM37 knockdown induces replicative senescence of MSCs with loss of full-length DNMT1, while simultaneous treatment of MSCs during expansion with ATM activators, such as resveratrol, and TET1 activator, vitamin C, induces the rejuvenation of late MSCs through the TRIM37/PARP1/DNMT1 pathway. Through gene knockout, TRIM37 and PARP1 are shown to be involved in MSC aging and bone repair in vivo. This study highlights the role of DNA hydroxymethylation and its regulators in stemness, offering strategies for therapeutic interventions.
Overview of Interference Management in Massive Multiple- Input Multiple-Output Systems for 5G Networks
Authors: Aikoun Yves Fidèle , Yin Sheng 
Published: March 2024

Abstract
New challenges have arisen in the field of wireless communication systems since the advent of Fifth Generation (5G) networks and the main objectives of delivering higher data rates, ultra-low latency, more reliability, and massive network capacity. While massive multiple-input multiple-output (MIMO) systems have emerged as a key technology for delivering a more uniform user experience to multiple users simultaneously, the deployment of multiple radiated elements in a confined area can lead to interference between the transmitted and received signals, resulting in the degradation of system efficiency. Therefore, interference management techniques are essential to mitigate this impact and enhance system performance. This review aims to explore interference management techniques in massive MIMO systems, including beamforming methods, non-orthogonal multiple access (NOMA), and joint transmission coordinated multi-point (JT-CoMP). The objective is to analyze the performance of these techniques in terms of the network capacity, coverage, and reliability and to compare their effectiveness in reducing interference. The valuable insights gained from this investigation will serve to inform the design and optimization of these systems.
WITHDRAWN: Outdoor UDA Depth Estimation with Intra-domain Attention and Cross-domain Edge Constraint
Authors: Peng Guo , Pan Shuguo , Hu Peng , Pei Ling , Yu Baoguo 
Published: March 2024

Abstract
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Using applicable theorems for solving circle geometry problems: A correlational study of senior high school students’ academic performance in circle geometry
Authors: Enoch Suglo Kabinaa 
Published: March 2024

Abstract
The primary objective of this research was to examine the theorems students employ when solving circle geometry problems and how this impacts their academic performance in the subject. The study was designed around the null hypothesis that students' use of applicable theorems for tackling circle geometry questions do not significantly affects their academic achievement in this area. It was a quantitative study involving a total population of 460 students, with a sample size of 210 selected through probability systematic sampling. Data collection utilized a questionnaire and an achievement test instrument, while analysis methods included descriptive statistics and simple linear regression analysis. The study found that the use of relevant theorems in solving circle geometry problems has a statistically significant impact on students' academic performance in this field \({r}^{2}\)=.012, t(210) = 8.585, p(< .001). Given this significant finding, it is recommended that educators and curriculum developers highlight the importance of theorem application in teaching circle geometry to enhance students' understanding and performance in the subject.
WITHDRAWN: Doxorubicin Involves in Cardiomyocyte Ferroptosis by Inhibiting STAT3 Phosphorylation and Reducing GPX4 Expression
Authors: Gao Ge , Shen Cheng , Wang Manman , Ji Cuiling , Fang Fang , Liu Zhichao , Chen Wenqiang , Zhang Jinguo 
Published: March 2024

Abstract
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Probing the role of glycocalyx in host-microbe interactions with systematic modification of the glycomic surface
Authors: Lebrilla Carlito , Sheng Ying , Grijaldo-Alvarez Sheryl Joyce , Xie Yixuan , Wong Maurice 
Published: March 2024

Abstract
Glycosylation is a conserved post-translational modification by which oligosaccharides are attached to a macromolecule, typically proteins and lipids found on the cell surface. In particular, protein glycosylation play an important role in host-microbe interactions which can further help in describing microbial pathogenicity, recognition by the host immune system and host susceptibility to infections. Glycan-mediated host-microbe interactions were empirically investigated using glycan arrays; however, characterizing the cellular glycocalyx via in situ binding with cells has not been explored. In this research, we established a metabolic-engineered host cell model that generates controlled glycan structure phenotypes on the cell surface. Specifically, we produced host cell surfaces that were primarily fucosylated, sialylated, undecorated complex-type structures, and high mannose-type structures. The manipulated host cell N-glycomes were characterized and confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. To validate glycans involved during infection, we employed adherence assays which showed fucosylated N-glycans on the colon cell line HCT116 cell surface significantly increased the number of adhered Salmonella enterica serovar Typhimurium (S. Typhi) compared to the other glycan subtypes. Furthermore, we showed that adherence of S. Typhi to HCT116 cells could be blocked by co-incubation with free fucose monosaccharides. The results proved that fucose residues on host cells bind with S. Typhi during bacterial infection. Proteomic analysis showed that the glycoengineering did not change the abundances of membrane proteins, indicating that host protein expression did not contribute to the increased adherence of S. Typhi. Meanwhile, glycoproteomic analysis yielded site-specific N-glycosylation information. Glycopeptides were identified and quantified using a standard glycoproteomic workflow. Collectively, our results suggested the importance of glycans in host-microbe interactions and provided a novel insight into the significance of host glycome during pathogenesis.
Challenges in Trials on Neonatal Sepsis- Case of ProSPoNS Trial &amp; Role of Central Endpoint Adjudication
Authors: Sinha Anju Pradhan , Raja Dilip K , Mahajan Kamlesh S , Gupta Subodh S , Poluru Ramesh , Kawade Anand S , Dhayma Girish , Sazawal Sunil , Bavdekar Ashish , Parida Sailajanandan , Nangia Sushma , Raut Abhishek V , Bethou Adhisivam , Devi Prabhabati , Gorpade Makrand , Fatima Tharika , Nayak Rashmita , Kapil Arti , Azam Mohd. , Khan Pearlin A , Pandey Ravindra Mohan , Arora Narendra Kumar 
Published: March 2024

Abstract
Background: Despite progress in reducing Infant mortality in India, neonatal mortality decline is slower, necessitating concerted efforts to achieve Sustainable Development Goal-3. A promising strategy aiming prevention of neonatal sepsis in high-risk, vulnerable, low birth weight neonates through an innovative intervention, including probiotic supplementation. This article communicates the decision by ProSPoNS trial investigators to establish a Central Endpoint Adjudication committee as an addendum to the published protocol in 'Trials 2021.'
Methods: In the pursuit of clarity regarding the primary outcome of Sepsis/PSBI in a clinical trial, a crucial decision was reached during the investigators' meeting at MGIMS Sevagram on 17th-18th August 2023. The unanimous consensus was to explicitly define "Physician diagnosed sepsis" as the primary study outcome, encompassing Sepsis/PSBI. This alignment aimed to synchronize the primary objective and outcome with the stated hypothesis, necessitating the establishment of a Central Endpoint Adjudication (CEA) process across all six trial sites.
To enact this, the CEA committee, chaired by an external Subject Expert and comprising Site Principal Investigators, a Trial Statistician, and a Microbiologist, will employ four criteria to determine 'Physician diagnosed sepsis' for each sickness event in a study participant. These criteria include Blood culture status, Sepsis screen status, PSBI/non-PSBI signs and symptoms, and the Clinical course during the event, including antibiotic usage. Importantly, this clarification maintains consistency with the approved study protocol (Protocol No.5/7/915/2012 Version 3.1 dated 14 Feb 2020), emphasizing the commitment to methodological transparency and adherence to predefined standards.
Results: The challenges faced in the trial implementation, such as complex multi-centric design, heterogeneity / extreme variation across sites, inconsistency with definition of sepsis in the neonatal/young infant population, remote vs. on-site training/monitoring during the Covid-19 Pandemic have been described and potential solutions to some of the challenges in clinical trials suggested.
Conclusions: The decision to utilize the guidance of a Central Endpoint Adjudication Committee has been suggested as a way forward in the ProSPoNS and other multicentre complex clinical trials.
Trial registration: Clinical Trial Registry of India (CTRI) CTRI/2019/05/019197. Registered
on 16 May 2019.
From Rainwater Harvesting to Groundwater Exploitation: Understanding theChanging Role of Farm Ponds and their Socio-economic Consequences in Maharashtra's Semi-Arid Region, India.
Authors: Warsi Taufique , Chemburkar Sarita , Yadav Ankita , Rupani Faraz , D'Souza Marcella 
Published: March 2024

Abstract
Groundwater plays a critical role in providing irrigation and drinking water in the drought-prone semi-arid region of Maharashtra, India. To address water scarcity, the government has promoted the construction of Farm Ponds (FPs) as a strategy to secure rural agrarian livelihoods and drought-proof the area. However, FPs, originally designed for rainwater harvesting, have now become commonly used as groundwater storage tanks, leading to overexploitation of groundwater by a few affluent farmers. This creates inequity in access to water by making it private and increases the vulnerability of other user communities. In this study, a systematic hydrogeological assessment was conducted, analysing 68 functional FPs constructed between 2009 and 2016 in six groundwater-vulnerable villages. The assessment focused on using Electrical Conductivity (EC) and Total Dissolved Solids (TDS) as parameters to delineate the zone of influence created by the feeding wells of FPs. Furthermore, the study utilized the Groundwater Survey and Development Agency’s (GSDA) recharge priority zone map to examine the distribution of lined FPs and identify areas where these ponds hinder recharge in high and moderate priority recharge zones and their socio-economic impacts on farmers were evaluated. The findings provide valuable insights into the relationship between the Zone of Influence and its socio-economic impacts on farmers, offering a comprehensive understanding of the distribution, practices, and ill effects of farm ponds.