bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision education – a call to action to transform medical education
Authors: Coates Wendy C. 
Published: February 2025

Abstract

Background
Institutions, departments, and individuals are increasingly facing challenges to determine how to enable their learners to acquire and curate rapidly changing knowledge and to foster the creation of lifelong learners in this information-rich digital era.

Methods
Much like the Precision Medicine initiative of 2015, in which diagnostic, treatment, and preventive care target individual patients based on their genetic and environmental profiles, educators can use the same principles to create a model of “Precision Education.”

Results
In this model, future facing individualizable educational infrastructure can consider innate qualities, learning style, behavior, environment, prior experience, expertise, and assessments.

Conclusion
Educators can utilize Artificial Intelligence, the Master Adaptive Learner model, and key components of Competency Based Medical Education to transform the evolution of Health Professions Education to meet the individual and systemic needs of tomorrow’s learners, educators, and institutions to improve educational and clinical outcomes.
Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid
Authors: Zhang Changchun , Lu Yuanshi , Huang Yuanxia 
Published: February 2025

Abstract

Background
Previous studies have shown that hyaluronic acid can delay the progression of knee osteoarthritis. Existing research has extracted a bright red fluid called cell-free fat extract from human adipose tissue, which may play an important role in delaying the progression of osteoarthritis. By comparing with intra-articular injection of hyaluronic acid, this study aimed to evaluate the effects of intra-articular injection of CEFFE on both clinical efficacy and the reduction of bone marrow edema in patients with early to mid-stage knee osteoarthritis.

Methods
A total of 48 patients with KOA (Kellgren-Lawrence grade II-III) symptoms were randomly divided into CEFFE group (24 cases) and HA group (24 cases). The patients in the CEFFE group received five injections of CEFFE (2 ml, 1 time/week), and the patients in the HA group received five injections of HA (2 ml, 1 ml/10 mg, 1 time/week). All the patients underwent clinical assessments using rating scales, including VAS, WOMAC and Lysholm Knee Score. These assessments were conducted at pre-treatment and at 3-week, 6-week, 3-month, and 6-month follow-up timepoints post-treatment. The clinical efficacy was evaluated at the 6-month follow-up after the treatment. The changes in subchondral bone marrow edema before and 6 months after treatment were assessed by grading BME on MRI of the affected knees.

Results
A total of 52 knees from 46 patients were included in the final analysis. Comparison of VAS score, WOMAC score, and Lysholm score between the two groups revealed that the differences between pre-treatment and 3 weeks post-treatment were not statistically significant (P > 0.05). For the VAS score and WOMAC score at 6 weeks, 3 months, and 6 months post-treatment, the CEFFE group was lower than the HA group (P < 0.05). For the Lysholm score, the CEFFE group was higher than the HA group (P < 0.05). Compared with pre-treatment, VAS scores and WOMAC scores were lower and Lysholm scores were higher at all post-treatment time points (P < 0.05). At 6 months post-treatment, the clinical efficacy of the CEFFE group was significantly better than that of the HA group (P < 0.05). At 6 months post-treatment, MRI grading showed that subchondral BME was reduced to different degrees in both groups, with the reduction being more pronounced in the CEFFE group (P < 0.05).

Conclusion
This study demonstrated that intra-articular injection of CEFFE into the knee joint could enhance the durability of tissue-specific cells (especially chondrocytes) and improve cellular metabolic processes, preventing the continued progression of osteoarthritis. Both CEFFE and HA were found to improve clinical symptoms and reduced subchondral bone marrow edema in the treatment of early to mid-stage knee osteoarthritis. However, CEFFE was more effective than HA in achieving these outcomes.
Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats
Authors: Li Manman , Ma Nange , Luo Shujie , Lu Yuyi , Yan Xixi , Li Yang , Li Xinmei , Li Zhuohui , Wu Zhipei , Wei Zhenyu , Wang Wei , Fan Huimei , Jiang Yu , Xiong Yan , Wang Yu 
Published: February 2025

Abstract

Background
Thermogenic adipose tissue, both beige and brown, experiences whitening as animals are exposed to warmth and age, but the potential mechanisms are not fully understood. In this study, we employed single-nucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes.

Results
Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues (pAT and oAT) exhibited progressive whitening in goats. Compared to the classic brown adipocytes in mice, goat thermogenic adipocytes were more closely related in gene expression patterns to human beige adipocytes, which was also confirmed by adipocyte type- and lineage-specific marker expression analysis. Furthermore, trajectory analysis revealed beige- and white-like adipocytes deriving from a common origin, coexisting and undergoing the transdifferentiation. In addition, differences in gene expression profiles and cell communication patterns (e.g., FGF and CALCR signaling) between oAT and pAT suggested a lower thermogenic capacity of oAT than that of pAT.

Conclusions
We constructed a cell atlas of goat pAT and oAT and descripted the characteristics of thermogenic adipocytes during whitening progression. Altogether, our results make a significant contribution to the molecular and cellular mechanisms behind the whitening of thermogenic adipocytes, and providing new insights into obesity prevention in humans and cold adaptation in animals.
Financial integration and economic growth: impact of renewable energy investments, technology transfer, and climate change on Europe and central Asian economies
Authors: Nassani Abdelmohsen A. , Imran Muhammad , Khan Shiraz , Zaman Khalid , Khan Haroon ur Rashid , Haffar Mohamed 
Published: February 2025

Abstract
Financial integration plays an important role in fostering global economic growth. Energy demand, technology transfer, sustainable production, and climate change have emerged as key drivers of sustainable development. This study explores the influence of financial integration, bolstered by renewable energy-induced trade, industry-driven technology, and environmental concerns, on regional economic growth. This study analyzes a panel of 39 high- and upper-middle-income European and Central Asian countries in 2017–2021. Using a panel generalized method of moments estimator, we reveal an inverted U-shaped relationship between regional economic growth and carbon emissions. Moreover, renewable energy-induced trade contributes positively to regional growth while trade openness and technology transfer further enhance this growth. Industry-driven technology negatively impacts regional growth owing to inadequate financial integration. The absence of sustainable energy infrastructure and industrialization also negatively impacts regional growth. Our study underscores the importance of increasing financial integration to promote sustainable energy-driven trade openness and technology transfer in line with the United Nations’ sustainable development agenda.
Intracranial ewings sarccoma mimicking middle 1/3rd parasagittal meningioma
Authors: Pandey Sharad , Kumar Pankaj , Paliwal Purnima , Saxena Achal , Deshpande Sumit , Monica N. 
Published: February 2025

Abstract

Background
Ewing sarcoma is a malignant tumor arising in bone and soft tissue in children and young adults. Intracranial Ewing’s Sarcoma may be found as a result of metastasis from extracranial sites. Primary Ewing’s Sarcoma affecting the central nervous system (CNS) is rare, which is commonly intraparenchymal located either supratentorial or in the spinal cord. An extra-axial /Extradural presentation of ES is extremely rare.

Case presentation
20-year-old female with intracranial Ewing’s sarcoma (ES) mimicking Right middle 1/3rd Parasagittal meningioma came with headache, Hemiparesis and urinary incontinence. The patient underwent craniotomy and Gross total resection of tumor. The postoperative imaging showed complete excision and underwent chemo-radiotherapy. This case highlights the diagnostic challenge that extra-axial/Dural Ewing’s sarcoma can pose for neurosurgeons as early diagnosis can prevent distant metastases.

Conclusion
Primary intracranial ES is a CNS primitive neuroectodermal tumor (PNET). Primary ES tumors can mimic intracranial meningiomas. Neurological symptoms are caused by large tumors with intracranial extension. Wide local excision is the treatment of choice. Chemotherapy has been shown to improve long-term survival rates and lower recurrence rates. Radiotherapy can be given as adjunct to improve survival rates.
Uncommon radiological findings of aggressive primary central nervous system lymphoma in an immunocompetent patient
Authors: Diker Sevda , Ortaş Nasıf , Ozankaya Çağın , Kararlı Kemal 
Published: February 2025

Abstract

Background
Primary central nervous system lymphoma (PCNSL) accounts for only 2–5% of all primary central nervous system (CNS) tumors. However, its radiologic features are variable and diagnosis can be difficult. Inappropriate treatments before biopsy can lead to inconclusive pathologic findings because the tumor is highly corticosteroid sensitive. Knowing the features related to PCNSL helps put this aggressive tumor on the list of initial diagnoses.

Case presentation
An immunocompetent 55-year-old male patient was admitted with epileptic seizures. Brain imaging findings such as intratumoral hemorrhages and increased perfusion led to an initial diagnosis of cranial metastases. Corticosteroid administration as an anti-edema treatment caused prominent regression of the tumor. Biopsy performed after tumor regrowth revealed highly aggressive diffuse large B cell lymphoma.

Conclusions
It is important to be aware of the usual, but also the rare features of PCNSL because it has distinct treatment and prognostic implications compared with other brain tumors and disorders.
Effects of sodium alginate and calcium on quality attributes of Shepherd’s purse under ultrasound impregnation during blanching processing
Authors: Wu Qihui , Zhang Zhongyuan , Bao Yihong , Li Dajing , Wen Xin , Feng Lei , Nie Meimei , Dai Zhuqing , Xu Yayuan 
Published: February 2025

Abstract
This study aimed to improve the quality of blanched Shepherd’s purse. Before blanching, Shepherd’s purse was impregnated, combined with ultrasonic treatment (US) (0, 5, 15 min) and different impregnators (calcium chloride (Ca), glucose (Gl), sodium alginate (Al)) to investigate the effects on the quality of blanched Shepherd’s purse. The contents of ascorbic acid, phenolic compounds and calcium were determined after blanching for 1 min, and the color, structure and volatile substances were analyzed. It was found that ultrasonic assisted sodium alginate impregnation for 15 min and calcium chloride treatment (Al + Ca + US15) produced very favorable effects on the quality characteristics of blanched Shepherd’s purse. Specifically, the ascorbic acid content of Al + Ca + US15 was 1.57 folds higher than that of the control group (CK), and the gallic acid and rutin content increased by 35.2% and 24.7%, respectively, compared to the CK. Additionally, the calcium content in Al + Ca + US15 was 1.27 folds higher than that in the CK. Furthermore, compared with CK, Al + Ca + US15 treatment of blanched Shepherd’s purse ΔE value was significantly reduced by 49.1%. Microstructure analysis revealed no significant difference in the internal cell space after Al + Ca + US15 treatment, and the cell morphology remained normal. In addition, the volatile data indicated that the impregnation treatment decreased the loss of volatiles after blanching. Overall, the treatment of ultrasound assisted impregnation has been found to be bio-protective for leaf vegetables when exposed to heat.

Graphical Abstract
Morphological spectrum of congenital anomalies of kidney and urinary tract in hospitalized pediatric population: a single-center prospective observational study
Authors: Bhat Nucksheeba Aziz , Ashraf Mohd , Khan Naseer Ul Hassan , Jan Muzafar , Sheikh Rayees Yousuf , Hussain Sheikh Quyoom , Sheikh Waseem Shafi 
Published: February 2025

Abstract

Background
The range of congenital anomalies affecting the kidneys and urinary tract (CAKUT) is wide, extending from asymptomatic ectopic kidneys to severe bilateral kidney agenesis.

Objective
To unveil the spectrum of morphological anomalies in the kidneys and urinary tract among patients hospitalized in the pediatric nephrology unit.

Methods
This is a cross-sectional study. Over 2 years, patients admitted to the pediatric nephrology unit and found to have CAKUT underwent comprehensive evaluation, including lab tests, imaging, and radionuclide scans for morphological characterization of the CAKUT subtype.

Results
Among the 650 patients admitted to the pediatric nephrology unit, 116 cases were identified as CAKUT, yielding a prevalence rate of 17.8% among patients hospitalized in the pediatric nephrology unit. Among these, 67 of 116 (57.7%) were male, with the majority (85%) aged 0 to 5 years. Abnormal ultrasonographic (USG) led to the evaluation of CAKUT in 46 of 116 (39.7%) cases, followed by recurrent fevers (19.8%), and urinary dribbling (12%). Anemia and renal dysfunction were the main laboratory abnormalities in 90/116 (77.5%) and 40/116 (34.5%) respectively). CAKUT cases were categorized as non-obstructive in 78/116 (68.1%) and obstructive in 37/116 (31.9%) based on USG findings. Primary vesicoureteric reflux (VUR) in 25/116 (21.6%) and ureteropelvic junction obstruction in 18/116 (15.6%) were the most common non-obstructive and obstructive anomalies respectively. Among VUR cases, grade II and grade III VUR accounted for 09/25(36%) and 7/25 (28%) respectively, associated with hypertension in 18/25 (72%) and renal scarring in 04/25 (16%). Ureteropelvic junction obstruction was present in 18/116 (15.5%), typically mild in 14/18 (61%) on ultrasonography. Posterior urethral valves accounted for 16/116 (13.7%) of cases, presenting with renal dysfunction in 13/16 (81%) and hydronephrosis in 12/16 (75%).

Conclusion
This study provides valuable insights into the clinical patterns and morphological diversity of CAKUT. These findings underscore the importance of early diagnosis and multidisciplinary management for optimizing outcomes.
Investigating causal effects of income on health using two-sample Mendelian randomisation
Authors: Igelström Erik , Munafò Marcus R. , Brumpton Ben M. , Davies Neil M. , Davey Smith George , Martikainen Pekka , Campbell Desmond , Craig Peter , Lewsey Jim , Katikireddi S. Vittal 
Published: February 2025

Abstract

Background
Income is associated with many health outcomes, but it is unclear how far this reflects a causal relationship. Mendelian randomisation (MR) uses genetic variation between individuals to investigate causal effects and may overcome some of the confounding issues inherent in many observational study designs.

Methods
We used two-sample MR using data from unrelated individuals to estimate the effect of log occupational income on indicators of mental health, physical health, and health-related behaviours. We investigated pleiotropy (direct effects of genotype on the outcome) using robust MR estimators, CAUSE, and multivariable MR including education as a co-exposure. We also investigated demographic factors and dynastic effects using within-family analyses, and misspecification of the primary phenotype using bidirectional MR and Steiger filtering.

Results
We found that a 10% increase in income lowered the odds of depression (OR 0.92 [95% CI 0.86–0.98]), death (0.91 [0.86–0.96]), and ever-smoking (OR 0.91 [0.86–0.96]), and reduced BMI (− 0.06 SD [− 0.11, − 0.003]). We found little evidence of an effect on alcohol consumption (− 0.02 SD [− 0.01, 0.05]) or subjective wellbeing (0.02 SD [− 0.003, 0.04]), or on two negative control outcomes, childhood asthma (OR 0.99 [0.87, 1.13]) and birth weight (− 0.02 SD, [− 0.01, 0.05]). Within-family analysis and multivariable MR including education and income were imprecise, and there was substantial overlap between the genotypes associated with income and education: out of 36 genetic variants significantly associated with income, 29 were also significantly associated with education.

Conclusions
MR evidence provides some limited support for causal effects of income on some mental health outcomes and health behaviours, but the lack of reliable evidence from approaches accounting for family-level confounding and potential pleiotropic effects of education places considerable caveats on this conclusion. MR may nevertheless be a useful complement to other observational study designs since its assumptions and limitations are radically different. Further research is needed using larger family-based genetic cohorts, and investigating the overlap between income and other socioeconomic measures.
Does the consumption of soya products affect cholesterol levels, blood pressure, or other cardiovascular health indicators?
Authors: Walendzik Aleksandra , Racisz Kinga , Duda Joanna , Kędzia Jakub , Obcowska Alicja , Racisz Paweł , Sencerek Łukasz 
Published: February 2025

Introduction and Purpose
Cardiovascular diseases (CVD) are the leading factor of mortality among people in the world. For this reason, people are trying to find factors that could improve the condition of the circulatory system. Soy is one of the most popular products in Asian cuisine. Its consumption is increasing due to a strong interest in vegetarian cuisine, in which soy is an important element. As its popularity grows, more and more research is being done to see if it has cardiovascular disease-preventing properties.
Aim of the study
This study aims to analyse the current state of knowledge regarding the effect of soy consumption on: hypertension, lipid profile, biomarkers of inflammation, vascular epithelium and impact on mortality caused by cardiovascular diseases.
Material and methods
For this review, we analyzed articles that we found in Pubmed and Google Scholar and that were related to our topic.
Conclusion
Many studies have shown a beneficial effect of soy products on lipid profile, especially in lowering LDL-C levels. Soy consumption may have an impact on modulating inflammatory markers, but further research is needed. Researchers have shown that soy may have a role in lowering blood pressure, especially in people with hypertension or an increased risk of CVD. Soy can be a part of our daily, healthy diet, but its impact on all-cause mortality and CVD depends on many factors such as people's age, comorbidity, dietary context and type of consumed soy ( e.g. fermented or not fermented).
Optimalisasi Partisipasi Masyarakat dalam Pembentukan Undang-Undang Melalui Petisi Online
Authors: Rivaldi Rivaldi , Mawahdah Adinda Olivia , Efendi Ivan Imam Efendi 
Published: February 2025

The House of Representatives is one of the state institutions that exercises legislative power as a representative of the people. However, in reality, the parliament has not been able to carry out its legislative function optimally because there is no guaranteed space for representative public participation. That way, one media is needed to be used to streamline the existence of community space in the middle of the parliament function. Based on that axiom, the author conducted this study to analyze the problem of public participation in the legislative process by the Parliament in terms of good governance principles. The research method used is normative juridical with a statutory approach and concept approach. Based on the results of the study, it shows that the resulting Law has not fully covered the interests of the community as a whole. This is because public participation in order to realize the principle of openness in the formation of laws has not been fulfilled optimally in the process. Thus, the use of Online Petitions accommodated by the parliament is considered as an initial initiative to improve the principle of openness in the implementation of Good Governance in the realm of government

Dewan Perwakilan Rakyat (DPR) merupakan salah satu lembaga negara yang menjalankan kekuasaan legislatif sebagai representasi rakyat. Namun, pada realitanya DPR belum dapat melaksanakan fungsi legislasi secara optimal karena tidak terjaminnya ruang partisipasi masyarakat yang representatif. Dengan begitu, dibutuhkan satu media yang digunakan untuk mengefektian keberadaan ruang masyarakat ditengah fungsi DPR. Berdasarkan aksioma itulah Penulis melakukan penelitian ini untuk menganalisa permasalahan partisipasi masyarakat terhadap proses legislasi oleh DPR ditinjau prinsip good governance. Adapun metode penelitian yang digunakan adalah yuridis normatif dengan pendekatan perundang-undangan (statute approach) dan pendekatan konsep (conceptual approach). Berdasarkan hasil penelitian menunjukkan menunjukkan bahwa Undang-Undang (UU) yang dihasilkan belum sepenuhnya mencakup kepentingan masyarakat secara menyeluruh. Hal ini dikarenakan partisipasi masyarakat dalam rangka mewujudkan prinsip keterbukaan dalam pembentukan UU belum terpenuhi secara maksimal dalam prosesnya. Maka, Pemanfaatan Petisi Online yang diakomodasi oleh DPR dianggap sebagai inisiatif awal untuk meningkatkan prinsip keterbukaan dalam implementasi Good Governance di ranah pemerintahan.