bluuebunny/crossref_metadata_2025_split huggingface dataset:
A two-stage bidirectional coevolution algorithm with reverse search for constrained multiobjective optimization
Authors: Liu Cancan , Wang Yujia , Xue Yunfeng 
Published: April 2024

Abstract
Constrained multiobjective optimization problems (CMOPs) are widespread in reality. The presence of constraints complicates the feasible region of the original problem and increases the difficulty of problem solving. There are not only feasible regions, but also large areas of infeasible regions in the objective space of CMOPs. Inspired by this, this paper proposes a bidirectional coevolution method with reverse search (BCRS) combined with a two-stage approach. In the first stage of evolution, constraints are ignored and the population is pushed toward promising regions. In the second stage, evolution is divided into two parts, i.e., the main population evolves toward the constrained Pareto front (CPF) within the feasible region, while the reverse population approaches the CPF from the infeasible region. Then a solution exchange strategy similar to weak cooperation is used between the two populations. The experimental results on benchmark functions and real-world problems show that the proposed algorithm exhibits superior or at least competitive performance compared to other state-of-the-art algorithms. It demonstrates BCRS is an effective algorithm for addressing CMOPs.

Graphical Abstract
The safety, quality evaluation, and lot release of COVID-19 vaccines imported and used in Nigeria from march 2021 to march 2022
Authors: Kanu N. M. , Adeyeye C. M. , Abiola V. O. , Adekunle–Segun O. , Adegoke E. M. , Akapo A. , Okezue M. A. 
Published: April 2024

AbstractCoronavirus disease (COVID-19) caused by the Severe Acute Respiratory Syndrome Corona 2 Virus (SARS-COV-2 Virus) was a major global health crisis that resulted in severe illness and death around the globe. The swift development of effective vaccines against the disease to mitigate severe illness and death was one of the greatest public health scientific achievements. Most of these vaccines required cold storage and were exported to many developing countries with resource limitations to verify the quality of these products. The National Agency for Food and Drug Administration and Control (NAFDAC) regulates the quality of vaccines imported into Nigeria. This study provides summaries of data collected and QC measures conducted on all the COVID-19 vaccines imported into Nigeria within 2021–2022. Cold-chain parameters and other data requirements for meeting international standards for assessing the quality of vaccines were conducted in ISO17025-accredited laboratories of the Nigerian FDA. QC tests used to assess the safety of the products included tests for sterility, bacterial endotoxin, abnormal toxicity, pH, Physical appearance, extractable volumes, protein tests, and DNA: protein ratios. The products yielded satisfactory compliance, however, there were unsatisfactory sterility and protein test results for two batches of the samples tested. There are additional non-QC regulatory measures employed by NAFDAC to ensure the safety of the COVID-19 vaccines, including supply chain management. Out of ninety-five batches of different COVID-19 vaccines evaluated, 95.5% passed sterility testing. There is a 100% pass of all the vaccines for the Bacteria Endotoxin Test while an 80% pass was observed for the protein content.
Public Health Responses to CBRN Terrorism in the Middle East and North Africa
Authors: Mani Zakaria , Plummer Virginia , Kuhn Lisa , Khorram-Manesh Amir , Tin Derrick , Goniewicz Krzysztof 
Published: April 2024

Abstract

Objective:
Escalating global challenges (such as disasters, conflict, and climate change) underline the importance of addressing Chemical, Biological, Radiological, and Nuclear (CBRN) terrorism for sustainable public health strategies. This study aims to provide a comprehensive epidemiological analysis of CBRN incidents in the Middle East and North Africa (MENA) region, emphasizing the necessity of sustainable responses to safeguard healthcare infrastructures.

Method:
Utilizing a retrospective approach, this research analyzes data from the Global Terrorism Database (GTD) covering the period from 2003 to 2020. The study focuses on examining the frequency, characteristics, and consequences of CBRN incidents in the MENA region to identify patterns and trends that pose significant challenges to public health systems.

Results:
The analysis revealed a significant clustering of CBRN incidents in Iraq and Syria, with a predominant involvement of chemical agents. These findings indicate the extensive impact of CBRN terrorism on healthcare infrastructures, highlighting the challenges in providing immediate health responses and the necessity for long-term recovery strategies.

Conclusions:
The study underscores the need for improved healthcare preparedness, robust emergency response systems, and the development of sustainable public health policies. Advocating for international collaboration, the research contributes to the strategic adaptation of healthcare systems to mitigate the impacts of CBRN terrorism, ensuring preparedness for future incidents in the MENA region and beyond.
The role of the cytochrome P450 superfamily in the skin
Authors: Chen Qianqian , Wang Tuan , Wu Xia , Yuan Huipu , Wei Yuan , Xiao Ying 
Published: April 2024

Abstract
In mammals, the skin acts as a barrier to prevent harmful environmental stimuli from entering the circulation. CYP450s are involved in drug biotransformation, exogenous and endogenous substrate metabolism, and maintaining the normal physiological function of the skin, as well as facilitating homeostasis of the internal environment. The expression pattern of CYP450s in the skin is tissue-specific and thus differs from the liver and other organs. The development of skin topical medications, and knowledge of the toxicity and side effects of these medications require a detailed understanding of the expression and function of skin-specific CYP450s. Thus, we summarized the expression of CYP450s in the skin, their function in endogenous metabolic physiology, aberrant CYP450 expression in skin diseases and the influence of environmental variables and medications. This information will serve as a crucial foundation for future studies on the skin, as well as for the design and development of new drugs for skin diseases including topical medications.
Silencing Conversational Silences
Authors: Klieber Anna 
Published: April 2024

AbstractThis paper aims to extend the discussion of silencing beyond the realm of speech and to the domain of conversational silences—that is, silences that have communicative functions in our conversational exchanges. I argue that, insofar as we can use silences to communicate, we can also be prevented from doing things with these silences. Alongside a threefold taxonomy I show the different ways in which this can happen, utilizing and extending Maitra's (2009) account of silencing to illustrate the wrong happening in these cases. This discussion not only highlights a new domain of silencing that has, so far, been underexplored, but also uncovers just how deep linguistic injustices can run.
Leader-contingent sanctions as a cause of violent political conflict
Authors: Mei Yu 
Published: April 2024

AbstractEconomic sanctions are a policy tool that great powers frequently use to interfere with domestic politics of another state. Regime change has been a primary goal of economic sanctions over the past decades. This article studies the relationship between leader-contingent sanctions—sanctions that are designed to impede the flow of revenue to a specific leader—and violent political conflict in target countries. I build a theoretical model to illuminate two mechanisms by which leader-contingent sanctions destabilize a regime—the Depletion Mechanism and the Instigation Mechanism. The Depletion Mechanism works when sanctions mechanically deplete the government's resources so that it becomes unable to buy off domestic opposition even by making the largest possible offer. The Instigation Mechanism implies that as sanctions decrease the benefit of negotiated settlement relative to war, the government may strategically choose to repress rather than buy off the opposition even when it is able to do so. Leader-contingent sanctions lead to bargaining failure by rewarding the opposition for revolt while reducing the government's ability and willingness to appease the opposition.
Characterisation of the mitochondrial genome and phylogenetic analysis of Toxocara apodemi (Nematoda: Ascarididae)
Authors: Gao Y. , Hu Y. , Xu S. , Liang H. , Lin H. , Yin T. H. , Zhao K. 
Published: April 2024

Abstract
We first sequenced and characterised the complete mitochondrial genome of Toxocara apodeme, then studied the evolutionary relationship of the species within Toxocaridae. The complete mitochondrial genome was amplified using PCR with 14 specific primers. The mitogenome length was 14303 bp in size, including 12 PCGs (encoding 3,423 amino acids), 22 tRNAs, 2 rRNAs, and 2 NCRs, with 68.38% A+T contents. The mt genomes of T. apodemi had relatively compact structures with 11 intergenic spacers and 5 overlaps. Comparative analyses of the nucleotide sequences of complete mt genomes showed that T. apodemi had higher identities with T. canis than other congeners. A sliding window analysis of 12 PCGs among 5 Toxocara species indicated that nad4 had the highest sequence divergence, and cox1 was the least variable gene. Relative synonymous codon usage showed that UUG, ACU, CCU, CGU, and UCU most frequently occurred in the complete genomes of T. apodemi. The Ka/Ks ratio showed that all Toxocara mt genes were subject to purification selection. The largest genetic distance between T. apodemi and the other 4 congeneric species was found in nad2, and the smallest was found in cox2. Phylogenetic analyses based on the concatenated amino acid sequences of 12 PCGs demonstrated that T. apodemi formed a distinct branch and was always a sister taxon to other congeneric species. The present study determined the complete mt genome sequences of T. apodemi, which provide novel genetic markers for further studies of the taxonomy, population genetics, and systematics of the Toxocaridae nematodes.
Extramural English as an individual difference variable in L2 research: Methodology matters
Authors: Sundqvist Pia 
Published: April 2024

Abstract
In light of findings from research on informal foreign/second language (L2) learning, with a focus on English as a target language and using the concept of extramural English (EE), this position paper argues that learners’ engagement in EE (through activities such as watching television or films or playing digital games) constitutes an important individual difference (ID) variable that needs to be included in studies that aim to measure L2 English proficiency or development. In addition, it is suggested that if EE as an ID variable is left out in such studies in the future, the rationale for exclusion should be clearly stated. This position paper also discusses research instruments and methods used in this area of research, the benefits and drawbacks of different methods, and identifies research gaps and under-researched learner groups. Further, it is argued that in some contexts, EE has replaced classroom activities as the starting point for and foundation of learning English.
Live birth derived from a markedly large polar body oocyte: a rare case report
Authors: Liu Yongxiang , Peng Xinliang , Liu Caifeng , Zhang Shuting , Weng Zhiwei , Yu Li , Zhou Shaohu , Huang Xuekun 
Published: April 2024

AbstractOocytes with excessively large first polar bodies (PB1) often occur in assisted reproductive procedures. Many times these oocytes are discarded without insemination and, as a result, the application of this portion of oocytes has scarcely been reported to date. Few studies have examined large PB1 oocytes in infertile women and have virtually entirely studied genetic variations for large PB1 oocyte abnormalities. Here, we describe an unusual case of a live birth from a remarkably large PB1 oocyte in a frozen embryo transfer (FET) cycle. This is the first instance of a successful live birth resulting from a PB1 oocyte with an extremely large polar body measuring 80 μM × 40 μM in size. The large PB1 oocyte was performed by an early rescue intracytoplasmic sperm injection (r-ICSI) and was formed into a blastocyst on day 5. Following FET, a healthy boy baby weighing 3100 g was finally delivered by caesarean section at 37 weeks and 5 days after conception. Additionally, there were no complications throughout the antenatal period or the perinatal phase of this following full-term delivery. In this study, it is revealed for the first time that a huge PB1 oocyte can be fertilized, resulting in the growth of a blastocyst, a subsequent pregnancy, and a live birth. This new information prompts us to reconsider the use of large PB1 oocytes. More insightful talks should be given attention to prevent the waste of embryos because not all oocytes with aberrant morphology are unavailable.
Strong Oceanic Forcing on Decadal Surface Temperature Variability Over Global Ocean
Authors: Gu Peng , Liu Zhengyu , Delworth Thomas L. 
Published: April 2024

AbstractSea surface temperature (SST) variability on decadal timescales has been associated with global and regional climate variability and impacts. The mechanisms that drive decadal SST variability, however, remain highly uncertain. Many previous studies have examined the role of atmospheric variability in driving decadal SST variations. Here we assess the strength of oceanic forcing in driving decadal SST variability in observations and state‐of‐the‐art climate models by analyzing the relationship between surface heat flux and SST. We find a largely similar pattern of decadal oceanic forcing across all ocean basins, characterized by oceanic forcing about twice the strength of the atmospheric forcing in the mid‐ and high latitude regions, but comparable or weaker than the atmospheric forcing in the subtropics. The decadal oceanic forcing is hypothesized to be associated with the wind‐driven oceanic circulation, which is common across all ocean basins.
The GFDL Variable‐Resolution Global Chemistry‐Climate Model for Research at the Nexus of US Climate and Air Quality Extremes
Authors: Lin Meiyun , Horowitz Larry W. , Zhao Ming , Harris Lucas , Ginoux Paul , Dunne John , Malyshev Sergey , Shevliakova Elena , Ahsan Hamza , Garner Steve , Paulot Fabien , Pouyaei Arman , Smith Steven J. , Xie Yuanyu , Zadeh Niki , Zhou Linjiong 
Published: April 2024

AbstractWe present a variable‐resolution global chemistry‐climate model (AM4VR) developed at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL) for research at the nexus of US climate and air quality extremes. AM4VR has a horizontal resolution of 13 km over the US, allowing it to resolve urban‐to‐rural chemical regimes, mesoscale convective systems, and land‐surface heterogeneity. With the resolution gradually reducing to 100 km over the Indian Ocean, we achieve multi‐decadal simulations driven by observed sea surface temperatures at 50% of the computational cost for a 25‐km uniform‐resolution grid. In contrast with GFDL's AM4.1 contributing to the sixth Coupled Model Intercomparison Project at 100 km resolution, AM4VR features much improved US climate mean patterns and variability. In particular, AM4VR shows improved representation of: precipitation seasonal‐to‐diurnal cycles and extremes, notably reducing the central US dry‐and‐warm bias; western US snowpack and summer drought, with implications for wildfires; and the North American monsoon, affecting dust storms. AM4VR exhibits excellent representation of winter precipitation, summer drought, and air pollution meteorology in California with complex terrain, enabling skillful prediction of both extreme summer ozone pollution and winter haze events in the Central Valley. AM4VR also provides vast improvements in the process‐level representations of biogenic volatile organic compound emissions, interactive dust emissions from land, and removal of air pollutants by terrestrial ecosystems. We highlight the value of increased model resolution in representing climate–air quality interactions through land‐biosphere feedbacks. AM4VR offers a novel opportunity to study global dimensions to US air quality, especially the role of Earth system feedbacks in a changing climate.
Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme
Authors: Oporto Espuelas Macarena , Burridge Saskia , Kirkwood Amy A. , Bonney Denise , Watts Kelly , Shenton Geoff , Jalowiec Katarzyna A. , O’Reilly Maeve A. , Roddie Claire , Castleton Anna , Clesham Katherine , Nicholson Emma , Alajangi Rajesh , Prabhu Shilpa , George Lindsay , Uttenthal Ben , Gabelli Maria , Neill Lorna , Besley Caroline , Chaganti Sridhar , Wynn Robert F. , Bartram Jack , Chiesa Robert , Lucchini Giovanna , Pavasovic Vesna , Rao Anupama , Rao Kanchan , Silva Juliana , Samarasinghe Sujith , Vora Ajay , Clark Peter , Cummins Michelle , Marks David I. , Amrolia Persis , Hough Rachael , Ghorashian Sara 
Published: April 2024

AbstractCAR T-cell therapy has transformed relapsed/refractory (r/r) B-cell precursor acute lymphoblastic leukaemia (B-ALL) management and outcomes, but following CAR T infusion, interventions are often needed. In a UK multicentre study, we retrospectively evaluated tisagenlecleucel outcomes in all eligible patients, analysing overall survival (OS) and event-free survival (EFS) with standard and stringent definitions, the latter including measurable residual disease (MRD) emergence and further anti-leukaemic therapy. Both intention-to-treat and infused cohorts were considered. We collected data on feasibility of delivery, manufacture, toxicity, cause of therapy failure and followed patients until death from any cause. Of 142 eligible patients, 125 received tisagenlecleucel, 115/125 (92%) achieved complete remission (CR/CRi). Severe cytokine release syndrome and neurotoxicity occurred in 16/123 (13%) and 10/123 (8.1%), procedural mortality was 3/126 (2.4%). The 2-year intent to treat OS and EFS were 65.2% (95%CI 57.2–74.2%) and 46.5% (95%CI 37.6–57.6%), 2-year intent to treat stringent EFS was 35.6% (95%CI 28.1–44.9%). Median OS was not reached. Sixty-two responding patients experienced CAR T failure by the stringent event definition. Post failure, 1-year OS and standard EFS were 61.2% (95%CI 49.3–75.8) and 55.3% (95%CI 43.6–70.2). Investigation of CAR T-cell therapy for B-ALL delivered on a country-wide basis, including following patients beyond therapy failure, provides clinicians with robust outcome measures. Previously, outcomes post CAR T-cell therapy failure were under-reported. Our data show that patients can be successfully salvaged in this context with good short-term survival.
Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines
Authors: Yildirim Nahide , Sarojam Lakshmi , Smith Victoria M. , Pieper Nadja M. , Anders Marius , Jackson Ross A. , Fuhrmann Dominik C. , Särchen Vinzenz , Brücher Daniela , Weigert Andreas , Dyer Martin J. S. , Vogler Meike 
Published: April 2024

AbstractBH3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-apoptotic function of B-Cell Lymphoma 2 (BCL2) proteins, particularly in leukemia and lymphoma cells primed for apoptosis. Mechanistically, BH3-mimetics may displace pro-apoptotic binding partners thus inducing BAX/BAK-mediated mitochondrial permeabilization followed by cytochrome c release, activation of the caspase cascade and apoptosis. Here, we describe a novel mode of caspase-independent cell death (CICD) induced by BH3-mimetics in a subset of diffuse large B-cell lymphoma (DLBCL) cells. Of note, rather than occurring via necroptosis, CICD induced immediately after mitochondrial permeabilization was associated with transcriptional reprogramming mediated by activation of c-Jun N-terminal Kinase (JNK) signaling and Activator Protein 1 (AP1). Thereby, CICD resulted in the JNK/AP1-mediated upregulation of inflammatory chemokines and increased migration of cytotoxic Natural Killer (NK) cells. Taken together, our study describes a novel mode of CICD triggered by BH3-mimetics that may alter the immune response towards dying cells.
Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study
Authors: Engjom Hilde Marie , Ramakrishnan Rema , Vousden Nicola , Bunch Kathryn , Morris Edward , Simpson Nigel , Gale Chris , O’Brien Pat , Quigley Maria , Brocklehurst Peter , Kurinczuk Jennifer J. , Knight Marian 
Published: April 2024

AbstractThere are few population-based studies of sufficient size and follow-up duration to have reliably assessed perinatal outcomes for pregnant women hospitalised with SARS-CoV-2 infection. The United Kingdom Obstetric Surveillance System (UKOSS) covers all 194 consultant-led UK maternity units and included all pregnant women admitted to hospital with an ongoing SARS-CoV-2 infection. Here we show that in this large national cohort comprising two years’ active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women. We provide strong evidence to recommend continuous surveillance of pregnancy outcomes in future pandemics and to continue to recommend SARS-CoV-2 vaccination in pregnancy to protect both mothers and babies.
Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Authors: Ke Shizhong , Dang Fabin , Wang Lin , Chen Jia-Yun , Naik Mandar T. , Li Wenxue , Thavamani Abhishek , Kim Nami , Naik Nandita M. , Sui Huaxiu , Tang Wei , Qiu Chenxi , Koikawa Kazuhiro , Batalini Felipe , Stern Gatof Emily , Isaza Daniela Arango , Patel Jaymin M. , Wang Xiaodong , Clohessy John G. , Heng Yujing J. , Lahav Galit , Liu Yansheng , Gray Nathanael S. , Zhou Xiao Zhen , Wei Wenyi , Wulf Gerburg M. , Lu Kun Ping 
Published: April 2024

AbstractInduced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known about its regulation after phosphorylation and how to effectively harness APC/CCDH1 activity to treat cancer. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)-catalyzed phosphorylation-dependent cis-trans prolyl isomerization drives tumor malignancy. However, the mechanisms controlling its protein turnover remain elusive. Through proteomic screens and structural characterizations, we identify a reciprocal antagonism of PIN1-APC/CCDH1 mediated by domain-oriented phosphorylation-dependent dual interactions as a fundamental mechanism governing mitotic protein stability and cell-cycle entry. Remarkably, combined PIN1 and cyclin-dependent protein kinases (CDKs) inhibition creates a positive feedback loop of PIN1 inhibition and APC/CCDH1 activation to irreversibly degrade PIN1 and other crucial mitotic proteins, which force permanent cell-cycle exit and trigger anti-tumor immunity, translating into synergistic efficacy against triple-negative breast cancer.