bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-cancer and single-cell analyses identify CD44 as an immunotherapy response predictor and regulating macrophage polarization and tumor progression in colorectal cancer
Authors: Zhang Qian , Wang Xinyu , Liu Yang , Xu Hao , Ye Chun 
Published: March 2024

IntroductionCluster of differentiation (CD) 44 is a non-kinase cell surface transmembrane glycoprotein critical for tumor maintenance and progression.MethodsWe conducted a systematic analysis of the expression profile and genomic alteration profile of CD44 in 33 types of cancer. The immune characteristics of CD44 were comprehensively explored by TIMER2.0 and CIBERSORT. In addition, the CD44 transcriptional landscape was examined at the single-cell level. Then, Pseudotime trajectory analysis of CD44 gene expression was performed using Monocle 2, and CellChat was utilized to compare the crosstalk differences between CD44+monocytes and CD44- monocytes. Tumor immune dysfunction and exclusion (TIDE) was used to evaluate the predictive ability of CD44 for immune checkpoint blockade (ICB) responses. The effects of CD44 on colorectal cancer (CRC) and macrophage polarization were investigated by knocking down the expression of CD44 in HCT-116 cell and macrophages in vitro.ResultsThe expression of CD44 elevated in most cancers, predicting unfavorable prognosis. In addditon, CD44 was correlation with immune cell infiltration and key immune regulators. CD44+ monocytes had a higher information flow intensity than CD44- monocytes. CD44 had good predictive ability for immune checkpoint blockade responses. Knockdown of CD44 inhibited the proliferation, migration, and invasion of HCT-116 cell in vitro. Knockdown of CD44 inhibited M2 macrophage polarization.DiscussionThese findings suggest that CD44 is involved in regulating tumor development, macrophage polarization, and has certain predictive value for patient clinical prognosis and response to immunotherapy.
Development and validation of the perceived restorative soundscape scale for children
Authors: Qin Jinhui , Zhao Xiaochen , He Jinlong , Jia Xiaohu , Zhang Bo 
Published: March 2024

IntroductionProlonged exposure to noise environments can induce stress and fatigue, even impacting individuals’ physical and mental health. Conversely, positive soundscapes can have a beneficial impact on health by alleviating stress and fatigue, promoting psychological recovery. To assess the restorative potential of soundscapes, various scales have been developed to create environments conducive to recovery. However, current research on perceptual restorativeness soundscape scales primarily focuses on adults, lacking a dedicated scale for children to evaluate the restorative potential of their surrounding acoustic environments from their perspective.MethodsTherefore, this study introduces the development and validation process of the Perceived Restorativeness of Soundscapes Scale for Children (PRSS-C) using survey questionnaires and data statistical analysis.ResultsThe study comprises two experiments. Experiment one aims to develop an effective PRSS-C, evaluating the restorative potential of soundscapes in different environments (urban center, urban suburb, and urban peripheral forest) among 185 children aged 10-12. Through a series of analyses, a dual-factor structure scale consisting of 15 items is developed, revealing that the restorative potential of soundscapes is lower in urban centers than in urban suburbs and lower in urban suburbs than in urban peripheral forests. Experiment two aims to further validate the effectiveness of PRSS-C. 244 children aged 10-12 assess the restorative potential of soundscapes in similar environments (two city parks) using the PRSS-C developed in experiment one. Factor analysis confirms the dual-factor structure, with assessment results indicating that the restorative potential of soundscapes in Temple of Heaven Park is lower than in the National Botanical Garden. This suggests that PRSS-C enables children to differentiate the restorative potential of soundscapes in similar environments within the same city, further confirming its effectiveness.DiscussionThis study successfully develops and validates the PRSS-C through two experiments. The use of this scale allows for the assessment of the restorative potential of acoustic environments surrounding children, providing an effective tool for evaluating and creating positive soundscapes for children.
Does nature-based social prescription improve mental health outcomes? A systematic review and meta-analysis
Authors: Menhas Rashid , Yang Lili , Saqib Zulkaif Ahmed , Younas Muhammad , Saeed Muhammad Muddasar 
Published: March 2024

BackgroundA nature-based social prescription (NBSP) is an approach to improving mental health outcomes that involves prescribing nature-based interventions as complementary or alternative therapy to traditional ones. A variety of advantages are available from NBSP for people looking to enhance their mental well-being. The effect size of the nature-based social prescriptions (NBSPs) has not been thoroughly evaluated by systematic reviews and meta-analyses.ObjectivesThe current study aimed to analyze existing studies and conduct a meta-analysis to determine the overall effect size of the nature-based social prescriptions (NBSP’s) outcomes on mental health.MethodsBy choosing the relevant papers from among those that were available, a meta-analysis was carried out in the current study. A systematic search of electronic databases (Pub Med, Web of Science, Scopus, Cochrane Library, Embase, CINAHL, and PsychINFO) was conducted to identify relevant studies. Studies were included if they evaluated the effects of NBSP on mental health outcomes. Effect sizes were calculated using the random effects model.ResultsMeta-analysis of interventions statistics shows that CBT (SMD −0.0035; 95% CI: [−0.5090; 0.5020]; Tau^2: 0.1011; Tau: 0.318), digital intervention (SMD −0.3654; 95% CI: [−0.5258; 1.2566]; Tau^2: 0.2976, Tau: 0.5455), music intervention (SMD −2.1281; 95% CI: [−0.4659; 4.7221]; Tau^2: 3.4046; Tau:1.8452), and psychological interventions (SMD −0.8529; 95% CI: [0.3051; 1.4007]; Tau^2: 0.1224; Tau: 0.3499) do not significantly impact. The other interventions [social belongingness, communication training, blue intervention, nature-based education, cognitive behavior group therapy (CBGT), social prescribing coordinator, self-help intervention, participatory, organizational intervention, inpatient services, brief diet, internet-based intervention, prenatal intervention, yoga and meditation, ergonomics training program, yoga nidra intervention, and storytelling] highlighted above are significant.ConclusionThe conclusion of the meta-analysis supports the idea that incorporating nature-based social prescription interventions into mental healthcare plans can effectively complement traditional therapies and improve mental health outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023412458, CRD42023412458.
The Involvement of the microRNAs miR-466c and miR-340 in the Palmitate-Mediated Dysregulation of Gonadotropin-Releasing Hormone Gene Expression
Authors: Nkechika Vanessa , Zhang Ningtong , Belsham Denise D. 
Published: March 2024

Diets high in saturated fatty acids are associated with obesity and infertility. Palmitate, the most prevalent circulating saturated fatty acid, is sensed by hypothalamic neurons, contributing to homeostatic dysregulation. Notably, palmitate elevates the mRNA levels of gonadotropin-releasing hormone (Gnrh) mRNA and its activating transcription factor, GATA binding protein 4 (Gata4). GATA4 is essential for basal Gnrh expression by binding to its enhancer region, with Oct-1 (Oct1) and CEBP-β (Cebpb) playing regulatory roles. The pre- and post-transcriptional control of Gnrh by palmitate have not been investigated. Given the ability of palmitate to alter microRNAs (miRNAs), we hypothesized that palmitate-mediated dysregulation of Gnrh mRNA involves specific miRNAs. In the mHypoA-GnRH/GFP neurons, palmitate significantly downregulated six miRNAs (miR-125a, miR-181b, miR-340, miR-351, miR-466c and miR-503), and the repression was attenuated by co-treatment with 100 μM of oleate. Subsequent mimic transfections revealed that miR-466c significantly downregulates Gnrh, Gata4, and Chop mRNA and increases Per2, whereas miR-340 upregulates Gnrh, Gata4, Oct1, Cebpb, and Per2 mRNA. Our findings suggest that palmitate may indirectly regulate Gnrh at both the pre- and post-transcriptional levels by altering miR-466c and miR-340, which in turn regulate transcription factor expression levels. In summary, palmitate-mediated dysregulation of Gnrh and, consequently, reproductive function involves parallel transcriptional mechanisms.
Fracture Dislocation of the Pisiform Bone in 14-Year-Old Boy—A Case Report
Authors: Procházka Ondřej , Sánchez Tomás , Kašpárková Karolína 
Published: March 2024

We present the case of a 14-year-old patient who suffered fracture dislocation of the pisiform bone (PB) along with fractures of the scaphoid, proximal radius, and proximal phalanx of the thumb due to high-energy trauma directly to the extended wrist. This combination of fractures has not been previously reported in the literature. Currently, there is no consensus in the literature regarding the optimal treatment approach for such cases. In our management, initial attempts at closed and open reduction were unsuccessful, leading to the decision for primary pisiformectomy. Our report includes a follow-up of 3.5 years, demonstrating a very good outcome. Based on this case and a few similar published cases, primary pisiformectomy appears to be a viable and well-accepted option, particularly among young patients. Additionally, we conducted a review of radiographic criteria and management strategies for this specific injury and related conditions.
Novel Study on Chemical Characterization and Antimicrobial, Antioxidant, and Anticholinesterase Activity of Essential Oil from Ecuadorian Bryophyte Syzygiella rubricaulis (Nees) Stephani
Authors: Morocho Vladimir , Benitez Ángel , Carrión Bárbara , Cartuche Luis 
Published: March 2024

Our research focuses on exploring the chemical composition and some biological properties of the essential oil derived from Syzygiella rubricaulis (Nees) Stephani, a bryophyte species. To conduct a comprehensive analysis, we utilized a DB5MS capillary column along with gas chromatography coupled to mass spectrometry (GC-MS) and flame ionization (GC-FID). The qualitative and quantitative examination revealed the presence of 50 compounds, with hydrocarbon sesquiterpenes (48.35%) and oxygenated sesquiterpenes (46.89%) being the predominant constituents. Noteworthy compounds identified include bicyclogermacrene (12.004%), cedranone <5-> (9.034%), spathulenol (6.835%), viridiflorol (6.334%), silphiperfol-5,7(14)-diene (6.216%), biotol <β-> (6.075%), guaiol (4.607%), viridiflorene (4.65%), and α-guaienol (3.883%). Furthermore, we assessed the antimicrobial, antioxidant, and anticholinesterase activity of the essential oil, revealing a compelling inhibitory effect against acetylcholinesterase (AChE) with an IC50 value of 26.75 ± 1.03 µg/mL and a moderate antimicrobial (MIC 500 µg/mL, Enterococcus faecium, Lysteria monocytogenes) and antioxidant effect (ABTS: SC50 343.38 and DPPH 2650.23 µg/mL). These findings suggest the potential therapeutic application of the bryophyte essential oil in the treatment of Alzheimer’s disease due to its potent anticholinesterase properties.
High-Sensitivity Seawater Refraction Index Optical Measurement Sensor Based on a Position-Sensitive Detector
Authors: Zhou Guanlong , Li Liyan , Zhou Yan , Chen Xinyu 
Published: March 2024

The refractive index of seawater is one of the essential parameters in ocean observation, so it is necessary to achieve high-precision seawater refractive index measurements. In this paper, we propose a method for measuring the refractive index of seawater, based on a position-sensitive detector (PSD). A theoretical model was established to depict the correlation between laser spot displacement and refractive index change, utilizing a combination of a position-sensitive detector and laser beam deflection principles. Based on this optical measurement method, a seawater refractive index measurement system was established. To effectively enhance the sensitivity of refractive index detection, a focusing lens was incorporated into the optical path of the measuring system, and simulations were conducted to investigate the impact of focal length on refractive index sensitivity. The calibration experiment of the measuring system was performed based on the relationship between the refractive index of seawater and underwater pressure (depth). By measuring laser spot displacement at different depths, changes in displacement, with respect to both refractive index and depth, were determined. The experimental results demonstrate that the system exhibits a sensitivity of 9.93×10−9 RIU (refractive index unit), and the refractive index deviation due to stability is calculated as ±7.54×10−9 RIU. Therefore, the feasibility of this highly sensitive measurement of seawater refractive index is verified. Since the sensitivity of the refractive index measurement of this measurement system is higher than the refractive index change caused by the wake of underwater vehicles, it can also be used in various applications for underwater vehicle wake measurement, as well as seawater refractive index measurement, such as the motion state monitoring of underwater navigation targets such as AUVs and ROVs.
Retrospective evaluation of COVID-19 incidence during smoking cessation treatment with varenicline
Authors: Barış Elif , Ömeroğlu Şimşek Gökçen , Arici Aylin , Gümüştekin Mukaddes , Kılınç Oğuz , Tosun Metiner 
Published: March 2024

Background: Cholinergic anti-inflammatory pathway endogenously controls inflammatory processes through activation of the α7-nicotinic acetylcholine receptor (α7nAChR). Varenicline, used in smoking cessation therapy, is a full α7nAChR agonist with anti-inflammatory effects. In this study, the frequency of coronavirus disease (COVID-19) was evaluated in patients using varenicline as a smoking cessation treatment.
Methods: In this retrospective cross-sectional study, records of the 111 patients admitted to Smoking Cessation Outpatient Clinic of Dokuz Eylul University Faculty of Medicine during the COVID-19 pandemic were evaluated. The development of COVID-19 disease according to the status of the patients being positive for SARS-COV-2 was evaluated comparatively in patients who received varenicline or not. Additionally, the disease symptoms were questioned.
Results: SARS-CoV-2 PCR positivity was not detected in any of 38 patients who regularly used varenicline out of 68 patients evaluated. SARS-CoV-2 PCR positivity was detected in 13 (43.3%) of 30 patients who received other treatments or irregularly used varenicline (p
Konsumsi rokok dan tinggi badan orangtua sebagai faktor risiko stunting anak usia 6-24 bulan di perkotaan
Authors: Sari Siska Puspita 
Published: March 2024

AbstrakLatar Belakang: Stunting adalah salah satu masalah gizi balita, menggambarkan kegagalan pertumbuhan linear yang terakumulasi sejak sebelum dan sesudah kelahiran yang diakibatkan oleh tidak tercukupinya asupan zat gizi. Batasan stunting apabila defsit dalam panjang badan menurut umur < -2 z-skor berdasarkan rujukan baku pertumbuhan World Health Organization. Stunting dipengaruhi oleh banyak faktor, termasuk konsumsi rokok dan tinggi badan orang tua. Di Yogyakarta cakupan konsumsi rokok orang tua termasuk tinggi (52.1%) dan prevalensi balita stunting mencapai reaches 15.11%. Maka dari itu, dibutuhkan penelitian terkait hubungan konsumsi rokok dan tinggi badan orang tua sebagai factor risiko kejadian stunting pada anak usia 6-24 bulan di Kota Yogyakarta. Tujuan : Menganalisis menganalisa konsumsi rokok orang tua sebagai faktor risiko kejadian stunting pada anak usia 6 – 24 bulan di Kota Yogyakarta. Metode : Penelitian ini merupakan penelitian observasional dengan rancangan case control, dengan subjek anak usia 6-24 bulan yang terdaftar di 3 Posyandu (Umbulharjo, Tegalrejo dan Kotagede) yang masuk ke dalam kriteria inklusi. Jumlah subjek sebanyak 121 kasus dan 121 kontrol. Analisis data univariat, bivariat menggunakan Chi-square, dan multivariat menggunakan uji regresi logistik ganda. Hasil : Penelitian ini menunjukkan bahwa sebanyak 58,68% orang tuanya merokok. Analisis bivariat menunjukkan bahwa tidak ada hubungan antara konsumsi rokok orang tua dengan kejadian stunting pada anak usia 6-24 bulan di Yogyakarta p=0,601; OR=1,15 yang berarti bahwa konsumsi rokok orang tua akan berisiko mempunyai anak yang mengalami stunting 1,15 kali lebih besar dibandingkan dengan anak yang orang tua tidak mengkonsumsi rokok. Hasil analisa multivariat menunjukkan setelah mengontrol tinggi badan ibu hubungan konsumsi rokok orang tua dengan kejadian stunting tidak bermakna pada anak usia 6-24 bulan di Yogyakarta (p=0,62; OR=1,15). Penelitian ini menunjukkan bahwa faktor prenatal lebih dominan jika dibandingkan faktor postnatal seperti konsumsi rokok dan tinggi badan orang tua pada anak usia 6-24 bulan di Yogyakarta. Kesimpulan : Tidak ada hubungan bermakna antara konsumsi rokok orang tua (postnatal) dengan kejadian stunting pada anak usia 6-24 bulan di Kota Yogyakarta karena lebih dominan faktor prenatal.
Response of lettuce seeds undergoing dormancy break and early senescence to plasma irradiation
Authors: Okumura Takamasa , Anan Teruki , Shi Heping , Attri Pankaj , Kamataki Kunihiro , Yamashita Naoto , Itagaki Naho , Shiratani Masaharu , Ishibashi Yushi , Koga Kazunori , Mildažienė Vida 
Published: March 2024

Abstract
This study reports the response of lettuce seeds undergoing dormancy breaking and early senescence to DBD plasma irradiation. A heat map of germination percentages at 12 h reveals that dormancy has broken at 39 days' storage, and that one minute of plasma irradiation enhances germination in dormant seeds. Plasma irradiation does not affect those seeds where dormancy has already broken. Early senescence via storage was estimated using ESR measurements and the molecular modification of quercetin. This study reveals that lettuce seed susceptibility to plasma irradiation depends on storage duration and conditions, with dormancy state as a critical variable modulating the impact of plasma irradiation.
Single-longitudinal-mode vortex Nd:YVO4 laser using a circular Dammann grating for pump shaping
Authors: Song Jiaxin , Yu Junjie , Cao Weilin , Li Yuefei , Zhang Dawei , Li Jianlang 
Published: March 2024

Abstract
In this research, a 1064 nm single-longitudinal-mode (SLM) vortex beam was generated from an annular-pumped Nd:YVO4 microchip laser, in which a circular Dammann grating was used to reshape the 808 nm pump light into an annular intensity profile. As a result, the laser emitted a SLM LG01 beam with a maximum output power of 192 mW. A straightforward technique for producing SLM vortex beams is made available by this work.
Rejuvenation of degraded Zener diodes with the electron wind force
Authors: Rahman Md Hafijur , Al-Mamun Nahid Sultan , Glavin Nicholas , Haque Aman , Ren Fan , Pearton Stephen , Wolfe Douglas E. 
Published: March 2024

Abstract
In this study, we explore the rejuvenation of a Zener diode degraded by high electrical stress, leading to a leftward shift, and broadening of the Zener breakdown voltage knee, alongside a 57% reduction in forward current. We employed a non-thermal annealing method involving high-density electric pulses with short pulse width and low frequency. The annealing process took <30 s at near-ambient temperature. Raman spectroscopy supports the electrical characterization, showing enhancement in crystallinity to explain the restoration of the breakdown knee followed by improvement in forward current by ∼85%.
ЗВ'ЯЗОК САРКОПЕНІЇ ЗІ СТЕАТОТИЧНОЮ ХВОРОБОЮ ПЕЧІНКИ АСОЦІЙОВАНОЮ З МЕТАБОЛІЧНОЮ ДИСФУНКЦІЄЮ
Authors: Півторак Катерина , Щербенюк Наталія , Півторак Наталія 
Published: March 2024

Співіснування остеопорозу і саркопенії нещодавно було розглянуто як синдром, названий «остеосаркопеніею» [1].Саркопенія у своїй основі має декілька патологічних процесів: зниження числа м'язових волокон, зменшення їх розміру, порушення іннервації міофібрил, а також жирова інфільтрація м'язів (міостеатоз) [2]. У ряді досліджень показано, що жирова інфільтрація м'язів не тільки призводить до втрати м'язової маси і сили, а й сприяє виникненню інсулінорезистентності, метаболічно - асоційованої стеатотичної хвороби печінки (МАСХП) та цукрового діабету 2-го типу [2].
Нещодавні дослідження показали, що скелетні м'язи і кістки діють як ендокринні органи. Зрілі м'язові волокна складаються з багатоядерних клітин, нездатних до поділу, тому зростання і регенерація м'язів відбуваються за рахунок проліферації клітин-сателітів. При саркопенії в першу чергу знижується кількість клітин-сателітів і волокон II типу, що призводить до неможливості здійснення пацієнтом швидких рухів.
Скелетні м'язи відіграють вирішальну роль у передачі сигналів інсуліну як первинна тканина, відповідальна за опосередковане інсуліном видалення глюкози. Зниження маси скелетних м'язів може викликати інсулінорезистентність і дисглікемію, що в кінцевому підсумку призведе до МАСХП і її характерних особливостей [5]. Окислювальний стрес і хронічне запалення викликають атрофію м'язів і призводять до стресових відповідей у гепатоцитах, що призводить до прогресування фіброзу печінки, пов'язаного з МАСГ- однією зі стадій розвитку МАСХП. Уточнено роль обтяжуючого фактору - гіперамоніємії. Аміак перетворюється в глутамат з подальшим перетворенням у глутамін з утворенням лейцину, яке відбувається в скелетних м'язах. У результаті цієї реакції порушується функція мітохондрій і знижується рівень аденозинтрифосфату, що призводить до погіршення скорочувальної функції і зменшення м'язової маси.