bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIOPHANTINE TRANSFERENCE PRINCIPLE OVER FUNCTION FIELDS
Authors: DAS SOURAV , GANGULY ARIJIT 
Published: February 2024

AbstractWe study the Diophantine transference principle over function fields. By adapting the approach of Beresnevich and Velani [‘An inhomogeneous transference principle and Diophantine approximation’, Proc. Lond. Math. Soc. (3)101 (2010), 821–851] to function fields, we extend many results from homogeneous to inhomogeneous Diophantine approximation. This also yields the inhomogeneous Baker–Sprindžuk conjecture over function fields and upper bounds for the general nonextremal scenario.
Temperance lives and landscape: Lady Elizabeth Biddulph, Lady Henry Somerset, and late nineteenth-century Ledbury
Authors: Beckingham David , Watkins Charles 
Published: February 2024

AbstractThis article considers the relationship of two prominent leaders of British women’s temperance, Lady Henry Somerset and Lady Elizabeth Biddulph. They were noteworthy for taking opposing sides when the British Women’s Temperance Association divided on the question of the political reach of its work. Somerset and Biddulph were elite women, daughters of earls and near neighbours around Ledbury, a centre of cider apple and hop cultivation in Herefordshire. Both made their first temperance pledge in the area. We examine their geographical proximity and consider the importance of local agricultural labour and landscapes to their temperance work.
Effects of healthy ageing and bilingualism on attention networks
Authors: Markiewicz Roksana , Rahman Foyzul , Fernandes Eunice G. , Limachya Rupali , Wetterlin Allison , Wheeldon Linda , Segaert Katrien 
Published: February 2024

Abstract
Both ageing and bilingualism can have positive as well as adverse cognitive effects. We investigated their combined impact on subcomponents of attention. We used the Attention Network Task to examine alerting, orienting, executive control and task-switching costs. Group comparisons revealed age-related declines for alerting alongside benefits for executive control, for mono- and bilinguals alike. For orienting, age-related decline was more pronounced for bilinguals than monolinguals. Task-switching was unaffected by age or language group. Within bilinguals, we found limited impact of individual differences in L2 proficiency, language switching or mixing: proficiency improves orienting and decreases switch costs, for young and older bilinguals alike; but no other individual differences effects were found. Thus, attention is a multi-faceted network, with clear adverse (alerting) and protective (executive control) ageing effects. We found these to be largely similar for mono- and bilinguals, with variability within bilinguals having only limited impact.
Wave Breaking Events and Their Link to Rossby Wave Packets and Atmospheric Blockings During Southern Hemisphere Summer
Authors: Pérez‐Fernández Iago , Barreiro Marcelo , Ehstand Noémie , Hernández‐García Emilio , López Cristobal 
Published: February 2024

AbstractRossby Wave Packets (RWPs) are atmospheric perturbations located at upper levels in mid‐latitudes which, in certain cases, terminate in Rossby Wave Breaking (RWB) events. When sufficiently persistent and spatially extended, these RWB events are synoptically identical to atmospheric blockings, which are linked to heatwaves and droughts. Thus, studying RWB events after RWPs propagation and their link with blocking is key to enhance extreme weather events detection 10–30 days in advance. Hence, here we assess (a) the occurrence of RWB events after the propagation of transient RWPs, (b) whether long‐lived RWPs (RWPs with a lifespan above 8 days, or LLRWPs) are linked to large‐scale RWB events that could form a blocking event, and (c) the proportion of blocking situations that occur near RWB events. To do so, we applied a tracking algorithm to detect transient RWPs in the southern hemisphere during summertime between 1979 and 2021, developed a wave breaking algorithm to identify RWB events, and searched for blocking events with different intensities. Results show that LLRWPs and the other RWPs displayed large‐scale RWB events around 40% of the time, and most RWB events in both distributions last around 1–2 days, which is not long enough to identify them as blocking situations. Nearly 17% of blockings have a RWB event nearby, but barely 5% of blockings are linked to RWPs, suggesting that transient RWPs are not strongly linked to blocking development. Lastly, large‐scale RWB events associated with RWPs that lasted less than 8 days are influenced by El Niño‐Southern Oscillation.
Magnetotelluric Imaging of the Central Himalayan Crust Away From Rift Zones
Authors: Wang Gang , Fang Hui , Lei Qing , Xu Xinxue , Liang Hongda , Zhang Yaoyang 
Published: February 2024

AbstractImaging the crustal structure and state of the Himalayan Orogenic Belt (HOB) is of great significance for understanding crustal deformation and its tectonic response in the collision front of the Indian‐Eurasian plates. To avoid the influence from the anomalies underneath the north‐south trending rifts, a three‐dimensional electrical resistivity model across the central HOB was obtained between the Dingjie‐Shenzha and Yadong‐Gulu rifts. No lower‐crustal conductor was found in the southern Lhasa Terrane, and the lower crust with a moderate resistivity value of approximately 100 Ωm is interpreted to be the residue of previous partial melting beneath the Gangdese porphyry copper deposits. The middle crust between the Main Himalayan Thrust and Southern Tibet Detachment System is electrically resistive to the north of the north Himalayan gneiss domes (NHGD) belt and conductive to the south. The middle crust in the northern Himalayas may have undergone partial melting and crystallization during southward migration and duplexing. There is a strong deep‐shallow coupling relationship in the central HOB, where an increase in the underthrusting angle of the Indian crust has resulted in a southward turn of the NHGD belt.
Eddy‐Mediated Turbulent Mixing of Oxygen in the Equatorial Pacific
Authors: Eddebbar Yassir A. , Whitt Daniel B. , Verdy Ariane , Mazloff Matthew R. , Subramanian Aneesh C. , Long Matthew C. 
Published: February 2024

AbstractIn the tropical Pacific, weak ventilation and intense microbial respiration at depth give rise to a low dissolved oxygen (O2) environment that is thought to be ventilated primarily by the equatorial current system (ECS). The role of mesoscale eddies and vertical mixing as potential pathways of O2 supply in this region, however, remains poorly known due to sparse observations and coarse model resolution. Using an eddy resolving simulation of ocean circulation and biogeochemistry, we assess the contribution of these processes to the O2 budget balance and find that vertical mixing of O2, which is modulated by the surface wind speed and the vertical shear of the eddying currents, contributes substantially to the replenishment of O2 in the upper equatorial Pacific thermocline, complementing the advective supply of O2 by the ECS and meridional circulation at depth. These transport processes vary seasonally in conjunction with the wind: mixing of O2 into the upper thermocline is strongest during boreal summer and fall when the vertical shear and eddy kinetic energy are intensified. The relationship between eddy activity and the downward mixing of O2 arises from the modulation of equatorial turbulence by Tropical Instability Waves via their impacts on the vertical shear. This interaction of processes across scales sustains a local pathway of O2 delivery into the equatorial Pacific interior and highlights the need for adequate observations and models of turbulent mixing and mesoscale processes for understanding and predicting the fate of the tropical Pacific O2 content in a warmer and more stratified ocean.
Early Thermal Histories of IAB Main Group Irons: Insights From Ca‐Phosphates in Campo del Cielo and Nantan
Authors: Li Y. , Mei A. , Hsu W. , Li S. 
Published: February 2024

AbstractCa‐phosphates in Campo del Cielo (CdC) and Nantan were comprehensively studied to provide insights into the thermal histories of the IAB main group (MG) and related irons. In CdC, apatite grains are characterized by (a) close intergrowth with troilite/graphite in border area between silicate and metal in most cases and (b) near‐flat rare earth elemental patterns (LaN/YbN = 0.6–0.7). This indicates they were formed during a metal‐silicate mixing event at a relatively high temperature. Combining with petrographic textures, we suggest that the replacement of high‐Ca pyroxene by low‐Ca pyroxene at ∼950–1,000°C could release Ca and facilitate the formation of apatite grains. In the Nantan nodule, Ca‐phosphates do not share a similar origin with those in CdC, as indicated by their different mineral chemistries and mineral associations. Ca‐phosphates and associated silicates could crystallize from a P‐C‐S‐rich metallic melt with the oxidation of lithophile elements. Combining all analyses from CdC and Nantan yielded a SIMS Pb‐Pb isochron age of 4,558 ± 56 Ma. Considering that all the IAB‐MG irons experienced a rapid high‐temperature cooling process, the age of 4,558 ± 56 Ma provides another line of evidence that the parent body of IAB‐MG and related irons experienced metal‐silicate mixing in first 50 Myr of solar system. The previously reported Ar‐Ar ages of ≤4.47 Ga could be related to the late reheating process(es). The degrees of late shock heating may vary from specimen to specimen.
Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy
Authors: Wu Yao , De Asis-Cruz Josepheen , Limperopoulos Catherine 
Published: February 2024

AbstractIn-utero exposure to maternal psychological distress is increasingly linked with disrupted fetal and neonatal brain development and long‐term neurobehavioral dysfunction in children and adults. Elevated maternal psychological distress is associated with changes in fetal brain structure and function, including reduced hippocampal and cerebellar volumes, increased cerebral cortical gyrification and sulcal depth, decreased brain metabolites (e.g., choline and creatine levels), and disrupted functional connectivity. After birth, reduced cerebral and cerebellar gray matter volumes, increased cerebral cortical gyrification, altered amygdala and hippocampal volumes, and disturbed brain microstructure and functional connectivity have been reported in the offspring months or even years after exposure to maternal distress during pregnancy. Additionally, adverse child neurodevelopment outcomes such as cognitive, language, learning, memory, social-emotional problems, and neuropsychiatric dysfunction are being increasingly reported after prenatal exposure to maternal distress. The mechanisms by which prenatal maternal psychological distress influences early brain development include but are not limited to impaired placental function, disrupted fetal epigenetic regulation, altered microbiome and inflammation, dysregulated hypothalamic pituitary adrenal axis, altered distribution of the fetal cardiac output to the brain, and disrupted maternal sleep and appetite. This review will appraise the available literature on the brain structural and functional outcomes and neurodevelopmental outcomes in the offspring of pregnant women experiencing elevated psychological distress. In addition, it will also provide an overview of the mechanistic underpinnings of brain development changes in stress response and discuss current treatments for elevated maternal psychological distress, including pharmacotherapy (e.g., selective serotonin reuptake inhibitors) and non-pharmacotherapy (e.g., cognitive-behavior therapy). Finally, it will end with a consideration of future directions in the field.
PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Authors: Park John J. , Hamad Sabine Abou , Stewart Ashleigh , Carlino Matteo S. , Lim Su Yin , Rizos Helen 
Published: February 2024

AbstractProtein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11 (GNAQ/GNA11) mutations in over 90% of uveal melanoma (UM). Phase I clinical trials of PKC inhibitors have shown modest response rates with no survival benefit in metastatic UM. Although PKC inhibitors actively suppress mitogen-activated protein kinase (MAPK) signalling in UM, the effect on other UM signalling cascades is not well understood. We examined the transcriptome of UM biopsies collected pre- and post-PKC inhibitor therapy and confirmed that MAPK, but not PI3K/AKT signalling, was inhibited early during treatment with the second-generation PKC inhibitor IDE196. Similarly, in GNAQ/GNA11-mutant UM cell models, PKC inhibitor monotherapy effectively suppressed MAPK activity, but PI3K/AKT signalling remained active, and thus, concurrent inhibition of PKC and PI3K/AKT signalling was required to synergistically induce cell death in a panel of GNAQ/GNA11-mutant UM cell lines. We also show that re-activation of MAPK signalling has a dominant role in regulating PKC inhibitor responses in UM and that PI3K/AKT signalling diminishes UM cell sensitivity to PKC inhibitor monotherapy. Thus, combination therapies targeting PKC and PKC-independent signalling nodes, including PI3K/AKT activity, are required to improve responses in patients with metastatic UM.
Comparing stem cells, transdifferentiation and brain organoids as tools for psychiatric research
Authors: Bellon Alfredo 
Published: February 2024

AbstractThe inaccessibility of neurons coming directly from patients has hindered our understanding of mental illnesses at the cellular level. To overcome this obstacle, six different cellular approaches that carry the genetic vulnerability to psychiatric disorders are currently available: Olfactory Neuroepithelial Cells, Mesenchymal Stem Cells, Pluripotent Monocytes, Induced Pluripotent Stem Cells, Induced Neuronal cells and more recently Brain Organoids. Here we contrast advantages and disadvantages of each of these six cell-based methodologies. Neuronal-like cells derived from pluripotent monocytes are presented in more detail as this technique was recently used in psychiatry for the first time. Among the parameters used for comparison are; accessibility, need for reprograming, time to deliver differentiated cells, differentiation efficiency, reproducibility of results and cost. We provide a timeline on the discovery of these cell-based methodologies, but, our main goal is to assist researchers selecting which cellular approach is best suited for any given project. This manuscript also aims to help readers better interpret results from the published literature. With this goal in mind, we end our work with a discussion about the differences and similarities between cell-based techniques and postmortem research, the only currently available tools that allow the study of mental illness in neurons or neuronal-like cells coming directly from patients.
ADHD medications use and risk of mortality and unintentional injuries: a population-based cohort study
Authors: Vasiliadis Helen-Maria , Lunghi Carlotta , Rahme Elham , Rochette Louis , Gignac Martin , Massamba Victoria , Diallo Fatoumata Binta , Fansi Alvine , Cortese Samuele , Lesage Alain 
Published: February 2024

AbstractWe assessed the association between the use of medications for attention-deficit/hyperactivity disorder (ADHD) and the risk of all-cause mortality and unintentional injuries leading to emergency department (ED) or hospital admission in individuals aged ≤24 years with ADHD. We conducted a population-based retrospective cohort study between 2000 and 2021 using Quebec health administrative data. Individuals were followed from the first ADHD diagnosis or ADHD medication claim until turning 25, death, or study end. Exposure was defined as mutually exclusive episodes of ADHD medication use and/or coverage under the public provincial drug plan (PDP): 1) covered and not treated with ADHD medication; 2) covered and treated with ADHD medication; and 3) not covered under the PDP. The risk of all-cause mortality and unintentional injuries associated with exposure episodes was estimated using multivariable survival analyses. The cohort included n = 217 192 individuals aged 1–24 years with a male to female ratio of close to 2:1. Compared to non-medication use, episodes of ADHD medication use, overall, were associated with reduced all-cause mortality (adjusted hazard ratio, aHR 0.61, 95% CI 0.48–0.76) and unintentional injury leading to ED (0.75, 0.74–0.77) or hospitalisation (0.71, 0.68–0.75). Episodes of stimulants were associated with a lower risk of all-cause mortality and reduced risk of unintentional injuries, while episodes with non-stimulants and with both stimulants and non-stimulants concomitantly were associated with reduced risk of unintentional injuries, but not of all-cause mortality. Although residual confounding cannot be excluded, stimulants may have a protective effect in terms of risk of all-cause mortality and both stimulants and non-stimulants for ADHD may reduce the risk of unintentional injuries. The findings of the current study should inform clinical decision making on the choice of starting a pharmacological treatment for ADHD, when a balance needs to be struck between expected benefits and possible risks.
µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
Authors: Nisbett Khalin E. , Vendruscolo Leandro F. , Koob George F. 
Published: February 2024

AbstractMood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation. Previous studies have demonstrated that oxytocin reduced depression- and anxiety-like behavior in male and female mice, and opioid receptor activation reduced depression-like behavior. However, it remains unclear whether the endogenous opioid system interacts with the oxytocin system to facilitate emotion regulation in male and female mice. We hypothesized that opioid receptor blockade would inhibit the anxiolytic- and antidepressant-like effects of oxytocin. In this study, we systemically administered naloxone, a preferential μ−opioid receptor antagonist, and then intracerebroventricularly administered oxytocin. We then tested mice on the elevated zero maze and the tail suspension tests, respective tests of anxiety- and depression-like behavior. Contrary to our initial hypothesis, naloxone potentiated the anxiolytic-like, but not the antidepressant-like, effect of oxytocin. Using a selective μ−opioid receptor antagonist, D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2, and a selective κ−opioid receptor antagonist, norbinaltorphimine, we demonstrate that μ−opioid receptor blockade potentiated the anxiolytic-like effect of oxytocin, whereas κ−opioid receptor blockade inhibited the oxytocin-induced anxiolytic-like effects. The present results suggest that endogenous opioids can regulate the oxytocin system to modulate anxiety-like behavior. Potential clinical implications of these findings are discussed.
Epigenome-wide association study identifies neonatal DNA methylation associated with two-year attention problems in children born very preterm
Authors: Camerota Marie , Lester Barry M. , Castellanos Francisco Xavier , Carter Brian S. , Check Jennifer , Helderman Jennifer , Hofheimer Julie A. , McGowan Elisabeth C. , Neal Charles R. , Pastyrnak Steven L. , Smith Lynne M. , O’Shea Thomas Michael , Marsit Carmen J. , Everson Todd M. 
Published: February 2024

AbstractPrior research has identified epigenetic predictors of attention problems in school-aged children but has not yet investigated these in young children, or children at elevated risk of attention problems due to preterm birth. The current study evaluated epigenome-wide associations between neonatal DNA methylation and attention problems at age 2 years in children born very preterm. Participants included 441 children from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study, a multi-site study of infants born < 30 weeks gestational age. DNA methylation was measured from buccal swabs collected at NICU discharge using the Illumina MethylationEPIC Bead Array. Attention problems were assessed at 2 years of adjusted age using the attention problems subscale of the Child Behavior Checklist (CBCL). After adjustment for multiple testing, DNA methylation at 33 CpG sites was associated with child attention problems. Differentially methylated CpG sites were located in genes previously linked to physical and mental health, including several genes associated with ADHD in prior epigenome-wide and genome-wide association studies. Several CpG sites were located in genes previously linked to exposure to prenatal risk factors in the NOVI sample. Neonatal epigenetics measured at NICU discharge could be useful in identifying preterm children at risk for long-term attention problems and related psychiatric disorders, who could benefit from early prevention and intervention efforts.
Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis
Authors: Loginovic Pavel , Wang Feiyi , Li Jiang , Ferrat Lauric , Mirshahi Uyenlinh L. , Rao H. Shanker , Petzold Axel , Tyrrell Jessica , Green Harry D. , Weedon Michael N. , Ganna Andrea , Tuomi Tiinamaija , Carey David J. ,   UKBB Eye & Vision Consortium,   FinnGen,   Geisinger-Regeneron DiscovEHR Collaboration, Oram Richard A. , Braithwaite Tasanee 
Published: February 2024

AbstractOptic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GRS) with demographic risk factors (age, sex) significantly improved MS prediction in undifferentiated ON; one standard deviation of MS-GRS increased the Hazard of MS 1.3-fold (95% confidence interval 1.07–1.55, P < 0.01). Participants stratified into quartiles of predicted risk developed incident MS at rates varying from 4% (95%CI 0.5–7%, lowest risk quartile) to 41% (95%CI 33–49%, highest risk quartile). The model replicated across two cohorts (Geisinger, USA, and FinnGen, Finland). This study indicates that a combined model might enhance individual MS risk stratification, paving the way for precision-based ON treatment and earlier MS disease-modifying therapy.