bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoglycemic effects of dracorhodin and dragon blood crude extract from Daemonorops draco
Authors: Ching Yung-Hao , Lin Fang-Mei , Chen Hong-Chi , Hsu Ching-Yun , P’ng Sze Yen , Lin Tai-No , Wang Yu-Chia , Lin Cheng-Jun , Chen Yi-Chi , Ho Tsung-Jung , Chen Hao-Ping 
Published: March 2024

Abstract
Background
Dragon blood is a red fruit resin from the palm tree Daemonorops draco and is a herbal ingredient used in the traditional Chinese medicine, “Jinchuang Ointment,” which is used to treat non-healing diabetic wounds. According to the Taiwan Herbal Pharmacopeia, the dracorhodin content in dragon blood should exceed 1.0%.

Results
Our findings indicate that dracorhodin and dragon blood crude extracts can stimulate glucose uptake in mouse muscle cells (C2C12) and primary rat aortic smooth muscle cells (RSMC). Dracorhodin is not the only active compound in dragon blood crude extracts from D. draco. Next, we orally administered crude dragon blood extracts to male B6 mice. The experimental group displayed a decreasing trend in fasting blood glucose levels from the second to tenth week. In summary, crude extracts of dragon blood from D. draco demonstrated in vivo hypoglycemic effects in B6 male mice.

Conclusions
We provide a scientific basis “Jinchuang ointment” in treating non-healing wounds in patients with diabetes.
Assessment of dietary patterns in celiac disease patients using factor analysis method and their relationship with dietary intakes and body mass index
Authors: Morvaridi Mehrnaz , Sadeghi Narges , Alavinejad Pezhman , Sadeghian Mehdi , Tahvilian Negin , Behbahani Hossein Bavi , Ebrahimi Sara , Farsi Farnaz 
Published: March 2024

Abstract
Background/Objectives
Celiac disease (CD) is a systemic and autoimmune enteropathy of the gastrointestinal tract with malabsorption characteristics. The only effective treatment for CD is adhere strictly to a gluten-free diet (GFD) throughout life. We evaluated the dietary patterns in celiac disease patients and their association with dietary intakes and anthropometric measurements in Iran.

Subjects/Methods
This is a case-control study on 182 participants who were referred to the Khuzestan Celiac Association, Iran. Nutritional information was collected using a validated 147-item semi-quantitative food frequency questionnaire (FFQ). The software Stata (StataCorp, Version 14.0) was used to analyze the data. Principal component analysis (PCA) was used to obtain participants’ dietary patterns.

Results
A significant relationship was observed between age and body mass index (BMI) across quartiles of the healthy dietary pattern score (P < 0.001, P = 0.001, and P = 0.001, respectively), indicating that as age and BMI increased, participants demonstrated greater adherence to the healthy dietary pattern. Individuals with the highest adherence to the healthy dietary pattern had the lowest odds ratio for celiac disease (CD) (Q1: reference; Q2: 1.96, 95% CI: 0.84–4.55; Q3: 0.61, 95% CI: 0.27–1.42; Q4: 0.10, 95% CI: 0.03–0.33, P trend < 0.001), and this association remained significant after adjusting for BMI (adjusted P trend = 0.003) and energy intake (adjusted P trend < 0.001). Moreover, there was a significant association between the lowest odds ratio for CD and the highest adherence to the unhealthy dietary pattern after adjustment for energy intake (Q1: reference; Q2: 0.38, 95% CI: 0.13–1.12; Q3: 0.21, 95% CI: 0.06–0.71; Q4: 0.07, 95% CI: 0.02–0.29, adjusted P trend < 0.001). Additionally, a significant association was observed between the odds ratio for CD and the mixed dietary pattern score (Q1: reference; Q2: 6.01, 95% CI: 2.29–15.72; Q3: 2.47, 95% CI: 0.93–6.55; Q4: 4.84, 95% CI: 1.84–12.66, P trend = 0.02), and this association remained significant after adjustment for energy intake (adjusted P trend < 0.001).

Conclusions
The findings of the present study indicate that individuals who adhere to healthy dietary patterns have a lower incidence of celiac disease.
Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Authors: Schlein Eva , Rokka Johanna , Odell Luke R. , van den Broek Sara Lopes , Herth Matthias M. , Battisti Umberto M. , Syvänen Stina , Sehlin Dag , Eriksson Jonas 
Published: March 2024

Abstract
Background
The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based ligands through the blood–brain barrier (BBB). To overcome this physiological obstacle, we have previously developed bispecific antibody ligands that pass through the BBB via receptor-mediated transcytosis. While these radiolabelled ligands have high affinity and specificity, their long residence time in the blood and brain, typical for large molecules, poses another challenge for PET imaging. A viable solution could be a two-step pre-targeting approach which involves the administration of a tagged antibody that accumulates at the target site in the brain and then clears from the blood, followed by administration of a small radiolabelled molecule with fast kinetics. This radiolabelled molecule can couple to the tagged antibody and thereby make the antibody localisation visible by PET imaging. The in vivo linkage can be achieved by using the inverse electron demand Diels–Alder reaction (IEDDA), with trans-cyclooctene (TCO) and tetrazine groups participating as reactants. In this study, two novel 18F-labelled tetrazines were synthesized and evaluated for their potential use as pre-targeting imaging agents, i.e., for their ability to rapidly enter the brain and, if unbound, to be efficiently cleared with minimal background retention.

Results
The two compounds, a methyl tetrazine [18F]MeTz and an H-tetrazine [18F]HTz were radiolabelled using a two-step procedure via [18F]F-Py-TFP synthesized on solid support followed by amidation with amine-bearing tetrazines, resulting in radiochemical yields of 24% and 22%, respectively, and a radiochemical purity of > 96%. In vivo PET imaging was performed to assess their suitability for in vivo pre-targeting. Time-activity curves from PET-scans showed [18F]MeTz to be the more pharmacokinetically suitable agent, given its fast and homogenous distribution in the brain and rapid clearance. However, in terms of rection kinetics, H-tetrazines are advantageous, exhibiting faster reaction rates in IEDDA reactions with dienophiles like trans-cyclooctenes, making [18F]HTz potentially more beneficial for pre-targeting applications.

Conclusion
This study demonstrates a significant potential of [18F]MeTz and [18F]HTz as agents for pre-targeted PET brain imaging due to their efficient brain uptake, swift clearance and appropriate chemical stability.
Why avoid naming diseases after animals? The case of “Molluscum contagiosum”
Authors: Machado Fabrizio M. , Salvador Rodrigo B. 
Published: March 2024

AbstractFor over 200 years, the name molluscum contagiosum—a dermatological disease—has unfairly associated molluscs (the second largest group of animals on the planet) with this highly contagious infectious disease. Herein, arguments are presented demonstrating the serious problem of continuing to use this name, including animal welfare concerns. Thus, to minimize any unnecessary impacts on the biodiversity and conservation of molluscs, we follow WHO best practices in naming diseases to suggest the use of the new term ‘wpox’ or ‘water warts’ as a synonym for molluscum contagiosum.
Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway
Authors: Zhang Yu-jing , Chen Li-feng , Li Xu , Chen Jian-hua , Tan Zhang-kui 
Published: March 2024

Abstract
Objectives
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which might trigger cartilage, bone damage, and disability. Recent studies have suggested that Tetramethylpyrazine (TMP), an alkaloid monomer isolated from the rhizome of the traditional herbal medicine Ligusticum wallichii Franch, exerts a broad spectrum of pharmacological properties, containing anti-inflammatory. This study aimed to analyze the role and underlying mechanism of TMP in RA.

Methods
Under Hypoxia condition, RA-Fibroblast-like synoviocyte (FLS) were treated with TMP at different doses. Cell viability, proliferation, cell cycle progression, and migration were detected using Cell Counting Kit-8 (CCK-8) assay, 5-ethynyl-2’-deoxyuridine (EdU) assay, flow cytometry assay, wound healing assay, and transwell assay. Cyclin D1, Proliferating cell nuclear antigen (PCNA), Matrix metalloproteinase-2 (MMP2), MMP9, and hypoxia-inducible factor-1α (HIF-1α) protein levels were measured using western blot assay. Interleukin-6 (IL-6) and IL-8 were evaluated using ELISA. Circular RNA (circRNA) hsa_circ_0005178 (circCDC42BPB), CDC42BPB, and HIF-1α expression were determined using real-time quantitative polymerase chain reaction (RT-qPCR). Binding between HIF-1α and CDC42BPB promoter was predicted by JASPAR and verified using dual-luciferase reporter and Chromatin immunoprecipitation (ChIP) assays.

Results
TMP might hinder FLS proliferation, cycle progression, migration, and inflammatory response under hypoxic conditions. CircCDC42BPB expression was increased in RA patients and RA-FLSs treated with hypoxia, while its level was obviously reduced in RA-FLSs treated with hypoxia and TMP. TMP might abolish hypoxia-induced circCDC42BPB expression. Upregulation of circCDC42BPB might partially overturn the repression of TMP on hypoxia-caused RA-FLS damage. TMP might regulate circCDC42BPB level via HIF-1α in RA-FLSs under hypoxic conditions.

Conclusion
TMP might block RA-FLS injury partly via regulating the HIF-1α- circCDC42BPB pathway, providing a promising therapeutic target for RA.
Design and development of an IoT-based intelligent water quality management system for aquaculture
Authors: Olanubi Olumide Oluseye , Akano Theddeus Tochukwu , Asaolu Olumuyiwa Sunday 
Published: March 2024

AbstractWater quality is generally known to directly affect the health and growth rate of aquatic organisms and determines the success of any aquaculture fish production. However, water quality problems are difficult to detect early in aquaculture production facilities, largely because it requires a high level of technical understanding of the physio-chemical properties of water. In this research, an IoT-based intelligent water quality management system for aquaculture was designed and developed to monitor temperature, pH, and turbidity. ESP32 Microcontroller programmed with the C programming language was used to implement the smart control module which received data from the sensors and transmitted to a cloud database. A web application was also developed which enabled real-time monitoring and control of the system by a user from anywhere in the world, via any internet-connected device. Alarms and notifications could be received via WhatsApp Messenger. The system demonstrated capacity to improve the efficiency and productivity of aquaculture production.
Pulmonary shunt in critical care: a practical approach with clinical scenarios
Authors: Raimondi Cominesi Davide , Forcione Mario , Pozzi Matteo , Giani Marco , Foti Giuseppe , Rezoagli Emanuele , Cipulli Francesco 
Published: March 2024

Abstract
Background
Pulmonary shunt refers to the passage of venous blood into the arterial blood system bypassing the alveoli-blood gas exchange. Pulmonary shunt is defined by a drop in the physiologic coupling of lung ventilation and lung perfusion. This may consequently lead to respiratory failure.

Main body
The pulmonary shunt assessment is often neglected. From a mathematical point of view, pulmonary shunt can be assessed by estimating the degree of mixing between oxygenated and deoxygenated blood. To compute the shunt, three key components are analyzed: the oxygen (O2) content in the central venous blood before gas exchange, the calculated O2 content in the pulmonary capillaries after gas exchange, and the O2 content in the arterial system, after the mixing of shunted and non-shunted blood. Computing the pulmonary shunt becomes of further importance in patients on extracorporeal membrane oxygenation (ECMO), as arterial oxygen levels may not directly reflect the gas exchange of the native lung.

Conclusion
In this review, the shunt analysis and its practical clinical applications in different scenarios are discussed by using an online shunt simulator.

Graphical Abstract
Mixed-Methods Study on the Responsiveness of the Comprehensive Score for Financial Toxicity Among People With Multiple Myeloma
Authors: Fiala Mark A. , Leblanc Matthew R. , Coccia Kathryn W. , Bandaru Shraddha , Silberstein Alice E. , Coles Theresa , Vij Ravi 
Published: March 2024

PURPOSE Financial toxicity is a contributor to the psychosocial burden of cancer care. There is no consensus measure of financial toxicity; however, recent studies have adopted the Comprehensive Score for Financial Toxicity (COST). Despite its growing popularity, data on the responsiveness to change of the COST instrument are lacking. To address this gap in the literature, we performed a sequential mixed-methods study of people with multiple myeloma. MATERIALS AND METHODS In the quantitative phase of the study, we collected COST scores at two time points approximately 8 weeks apart from 72 patients. In the qualitative phase, we conducted semistructured interviews with a subset of 12 patients who reported the largest changes in scores. The qualitative data were analyzed using a deductive coding scheme developed using the Framework Method in the context of a commonly cited conceptual model of financial toxicity. RESULTS The median absolute change in COST scores was four points (IQR, 2-6). Only 13% of the sample had the same COST scores at both assessments; 38% had an improved score and 50% had a worsened score. Only, seven of the 12 patients (58%) interviewed reported changes to one or more of the constructs in the conceptual model of financial toxicity. Most commonly, changes to out-of-pocket medical costs were reported (5/12). Changes to nonmedical expenses (n = 2) and subjective financial distress without changes to objective financial burden (n = 2) were also reported. CONCLUSION Additional research is needed to explicate changes in COST scores over time.
Local Entanglements in the History of Mathematical Economics
Authors: Carvajalino Juan , Michael Mueller Thomas 
Published: March 2024

Abstract
This essay introduces a special issue of History of Political Economy titled “Local Entanglements in the History of Mathematical Economics.” The articles in the special issue share a particular historiographical approach, characterized by the name of “local entanglements.” The introduction defines the approach and explains why it can contribute in an original way to the history of economics.
The Frame for the Not-Yet Existent: How American, European, and Soviet Scholars Jointly Shaped Modern Mathematical Economics
Authors: Boldyrev Ivan 
Published: March 2024

Abstract
This article tells the story of the first international topological conference in Moscow (1935), an outstanding event that, for the first time, brought together the most notable American, European, and Soviet mathematicians, including those who would later play decisive roles in the mathematization of economics: John von Neumann, Leonid Kantorovich, and Albert W. Tucker. The fact that Kantorovich was in contact with von Neumann and his closest colleagues, Solomon Lefschetz and Garrett Birkhoff, is hardly appreciated in the histories of mathematics and mathematical economics. Their brief academic exchange was interrupted by the increasing international isolation of Soviet mathematics and by the wars that ensued. The article provides a historical account of the conference and traces the intellectual and personal affinities of Soviet and non-Soviet mathematicians, as well as their conceptual innovations. It argues that the conference, as a singular event linking several research communities, mattered for the development of various formal frameworks and their dissemination, contributing to the intellectual landscape in which postwar mathematical economics could emerge. The article calls for a deeper analysis of conceptual affinities and motivations in applying mathematics to economics and for a more nuanced narrative linking these motivations to social and political contexts of economic modeling.
MIT and the Origins of the Modern Theory of Asset Pricing
Authors: Backhouse Roger E. 
Published: March 2024

Abstract
This article argues that it was no coincidence that one of the places in which the modern theory of finance was developed was the Massachusetts Institute of Technology. Not only had it attracted Paul Samuelson, who had a long-standing interest in the problem, but its academic culture as a science-focused engineering school that fostered a competitive atmosphere and close relations between its economics department and business school was conducive to the development of such theories.
The Impact of Intracranial Pressure Telesensors: An Observational Propensity-Matched Control Analysis of Service Demand and Costs
Authors: Pandit Anand S. , Kamal Muhammad A. , Reischer Gerda , Aldabbagh Yousif , Alradhawi Mohammad , Lee Faith M. Y. , Sekhon Priya P. , Moncur Eleanor M. , Banks Ptolemy D. W. , Thompson Simon , Thorne Lewis , Watkins Laurence D. , Toma Ahmed K. 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Implantable telemetric intracranial pressure (ICP) sensors (telesensors) enable routine, noninvasive ICP feedback, aiding clinical decision-making and attribution of pressure-related symptoms in patients with cerebrospinal fluid shunt systems. Here, we aim to explore the impact of these devices on service demand and costs in patients with adult hydrocephalus.

METHODS:
We performed an observational propensity-matched control study, comparing patients who had an MScio/Sensor Reservoir (Christoph Miethke, GmbH & Co) against those with a nontelemetric reservoir inserted between March 2016 and March 2018. Patients were matched on demographics, diagnosis, shunt-type, and revision status. Service usage was recorded with frequencies of neurosurgical admissions, outpatient clinics, scans, and further surgical procedures in the 2 years before and after shunt insertion.

RESULTS:
In total, 136 patients, 73 telesensors, and 63 controls were included in this study (48 matched pairs). Telesensor use led to a significant decrease in neurosurgical inpatient admissions, radiographic encounters, and procedures including ICP monitoring. After multivariate adjustment, the mean cumulative saving after 2 years was £5236 ($6338) in telesensor patients (£5498 on matched pair analysis). On break-even analysis, cost-savings were likely to be achieved within 8 months of clinical use, postimplantation. Telesensor patients also experienced a significant reduction in imaging-associated radiation (4 mSv) over 2 years.

CONCLUSION:
The findings of this exploratory study reveal that telesensor implantation is associated with reduced service demand and provides net financial savings from an institutional perspective. Moreover, telesensor patients required fewer appointments, invasive procedures, and had less radiation exposure, indicating an improvement in both their experience and safety.
Prior Information and Consumer Search: Evidence from Eye Tracking
Authors: Ursu Raluca Mihaela , Erdem Tülin , Wang Qingliang , Zhang Qianyun 
Published: March 2024

Do consumers search the brands they know more or less frequently than the brands with which they are unfamiliar? In this paper, we attempt to answer this question using data from an experiment with two novel features: (i) survey information on consumers’ prior brand ownership, familiarity with each brand, and prior experience using different product features and (ii) eye-tracking data capturing search behavior at a very granular level. We find that consumers are generally more likely to search and buy brands they own and with which they are familiar, highlighting the importance of accounting for prior information. For this reason, we develop a search model in which both the information obtained during the search process and the information possessed by consumers prior to search are allowed to influence search and purchase decisions. Our model contributes to prior work by modeling search at the brand and attribute levels within a Bayesian learning framework. Using this model, we then quantify the impact of prior information on consumer choices as well as document the estimation bias arising when prior information is absent from the model. Finally, through a series of counterfactuals, we explore the managerial value of prior information data. This paper was accepted by Matt Shum, marketing. Funding: Q. Wang acknowledges financial support from the National Science Foundation of China [Grant 72072145] and the Natural Science Basic Research Program of Shaanxi Province [Grant 2020JQ-226]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.00611 .
Comparison of laparoscopic cholecystectomy in children at paediatric centres and adult centres: a systematic review and meta-analysis
Authors: Sinha A , Mattson A , Njere I , Sinha CK 
Published: March 2024

Introduction Paediatric laparoscopic cholecystectomy (LC) is performed by both paediatric and adult surgeons. The aim of this review was to compare outcomes at paediatric centres (PCs) and adult centres (ACs). Methods A literature search was conducted, in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines, for papers published between January 2000 and December 2020. Statistical analysis was performed using Stata® version 16 (StataCorp, College Station, TX, US). Results A total of 92 studies involving 74,852 paediatric LCs met the inclusion criteria. Over half (59%) of the LCs were performed at ACs. No significant differences were noted in the male-to-female ratio, mean age or mean body mass index between PCs and ACs. The main indications were cholelithiasis (34.1% vs 34.4% respectively, p=0.83) and biliary dyskinesia (17.0% vs 23.5% respectively, p<0.01). There was no significant difference in the median inpatient stay (2.52 vs 2.44 days respectively, p=0.89). Bile duct injury was a major complication (0.80% vs 0.37% respectively, p<0.01). Reoperation rates (2.37% vs 0.74% respectively, p<0.01) and conversion to open surgery (1.97% vs 4.74% respectively, p<0.01) were also significantly different. Meta-analysis showed no significant difference in overall complications (p=0.92). Conclusions The number of LCs performed, intraoperative cholangiography use and conversion rates were higher at ACs whereas bile duct injury and reoperation rates were higher at PCs. Despite a higher incidence of bile duct injury at PCs, the incidence at both PCs and ACs was <1%. In complex cases, a joint operation by both paediatric and adult surgeons might be a better approach to further improve outcomes. Overall, LC was found to be a safe operation with comparable outcomes at PCs and ACs.