bluuebunny/crossref_metadata_2025_split huggingface dataset:
α‐Chlorobenzyl Isocyanates in a New Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones.
Authors: Vovk M. V. , Sukach V. A. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Evaluation as AChE Inhibitors of New Indanones and Thiaindanones Related to Donepezil.
Authors: Dallemagne Patrick , et al. et al. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intra‐ and Intermolecular Trapping of Cyclopentapyrazine Carbenes Derived from 1,2‐Dialkynylimidazoles.
Authors: Nadipuram Asha K. , Kerwin Sean M. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemistry of Acyl(imidoyl)ketenes. Part 9. Synthesis and Thermolysis of 3‐Aroyl‐8‐chloro‐1,2‐dihydro‐4H‐pyrrolo[2,1‐c] [1,4]benzoxazine‐1,2,4‐triones.
Authors: Semenova T. D. , Krasnykh O. P. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substituted and Condensed Tetrahydrospiro[benzo‐2‐azepinecyclohexanes] from 1‐Cyano‐ and 1‐Carbamoyl‐5‐methyl‐4,5‐dihydro‐3H‐spiro [benzo‐2‐azepine‐3,1′‐cyclohexanes].
Authors: Varlamov A. V. , Grudinin D. G. , Eganov A. A. , Chernyshev A. I. , Levov A. N. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Approach to Synthesis of Tetrahydrobenzo[b]thieno[3,2‐d]azocines.
Authors: Voskressensky L. G. , Borisova T. N. , Listratova A. V. , Tolkunov S. V. , Varlamov A. V. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Fungicidal Activities of 2‐Silatranyl Propylamino‐4‐substituted Phenyl(hydrogen)‐5,5‐dimethyl‐1,3,2‐dioxaphosphinanes‐2‐oxides (Sulfides).
Authors: Wan Shi‐Guan , Yang Xing‐Yu , Yu Yan , Liu Chang 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formosadimers A, B, and C from the Bark of Calocedrus macrolepis var. formosana
Authors: Hsieh Chin‐Lin , Tseng Mei‐Huims , Kuo Yueh‐Hsiung 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Bis‐spirolabdane‐Type Diterpenoids from Leonurus heterophyllus Sw.
Authors: Giang Phan Minh , Son Phan Tong , Matsunami Katsuyoshi , Otsuka Hideaki 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Expeditious Synthesis of Bistratamide H Using a New Fluorous Protecting Group
Authors: Nakamura Yutaka , Okumura Kazuo , Kojima Masaru , Takeuchi Seiji 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hypoglycemic Activity of a New Carbohydrate Isolated from the Roots of Psacalium peltatum.
Authors: Contreras Claudia , Roman Ruben , Perez Cuauhtemoc , Alarcon Francisco , Zavala Miguel , Perez Salud 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bioactive Constituents from Chinese Natural Medicines. Part 15. Inhibitory Effect on Aldose Reductase and Structures of Saussureosides A and B from Saussurea medusa
Authors: Xie Haihui , Wang Tao , Matsuda Hisashi , Morikawa Toshio , Yoshikawa Masayuki , Tani Tadato 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Base‐Promoted Rearrangement of Sugar Epoxides to Unsaturated Sugars.
Authors: Wang Yuan , Li Qin , Cheng Shuihong , Wu Yanfen , Guo Dongjie , Fan Qiu‐Hua , Wang Xiaofang , Zhang Li‐He , Ye Xin‐Shan 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Synthesis and Structure of Linear and Dendritic Thiourea‐Linked Glycooligomers.
Authors: Jimenez Blanco Jose L. , Bootello Purificacion , Ortiz Mellet Carmen , Garcia Fernandez Jose M. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Chemical Synthesis of Bioactive Glycosylphosphatidylinositols from Trypanosoma cruzi Containing an Unsaturated Fatty Acid in the Lipid.
Authors: Yashunsky Dmitry V. , Borodkin Vladimir S. , Ferguson Michael A. J. , Nikolaev Andrei V. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Original and Rapid Access to New Alkaloid Analogues of Neocryptolepine: Synthesis of Substituted 6‐Methyl‐6H‐indolo[2,3‐b]quinolines via TDAE Strategy.
Authors: Amiri‐Attou Ouassila , Terme Thierry , Vanelle Patrice 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis Studies on Poison‐Frog Alkaloid 261C.
Authors: Toyooka Naoki , Kawasaki Masashi , Nemoto Hideo , Awale Suresh , Tezuka Yasuhiro , Kadota Shigetoshi 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Use of the Intramolecular Heck Reaction for Forming Congested Quaternary Carbon Stereocenters. Stereocontrolled Total Synthesis of (.+‐.)‐Gelsemine.
Authors: Madin Andrew , O'Donnell Christopher J. , Oh Taeboem , Old David W. , Overman Larry E. , Sharp Matthew J. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Silyl Method for the Synthesis of 1‐[2‐(Phenoxy)ethyl]uracils.
Authors: Novikov M. S. , Ozerov A. A. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dihydrotrichodimerol and Tetrahydrotrichodimerol, Two New Bisorbicillinoids, from a Marine‐Derived Penicillium terrestre.
Authors: Liu Weizhong , Gu Qianqun , Zhu Weiming , Cui Chengbin , Fan Guotao 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
FR177391, a New anti‐Hyperlipidemic Agent from Serratia. Part 1. Taxonomy, Fermentation, Isolation, Physico‐chemical Properties, Structure Elucidation and Biological Activities.
Authors: Sato Bunji , Nakajima Hidenori , Fujita Takashi , Takase Shigehiro , Yoshimura Seiji , Kinoshita Takayoshi , Terano Hiroshi 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ErG: 2D Pharmacophore Descriptions for Scaffold Hopping.
Authors: Stiefl Nikolaus , Watson Ian A. , Baumann Knut , Zaliani Andrea 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Control of Metal‐Ion Composition in the Synthesis of Ternary II‐II′‐VI Nanoparticles by Using a Mixed‐Metal Cluster Precursor Approach.
Authors: DeGroot Marty W. , Roesner Harald , Corrigan John F. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nearly Monodisperse Cu2O and CuO Nanospheres: Preparation and Applications for Sensitive Gas Sensors.
Authors: Zhang Jiatao , Liu Junfeng , Peng Qing , Wang Xun , Li Yadong 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Interplay of Magnetism, Structure and Superconductivity in Heavy‐Fermion Systems CeMIn5 and PuMGa5
Authors: Thompson J. D. , Nicklas M. , Sidorov V. A. , Bauer E. D. , Movskovich R. , Curro N. J. , Sarrao J. L. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Improvement of High Frequency Properties of Nickel—Zinc—Copper Ferrites
Authors: Lebourgeois R. , Ganne J.‐P. , Peyresoubes G. , Rebernak W. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rare‐Earth Metal‐Rich Tellurides — A Spectrum of Solid‐State Chemistry, Metal—Metal Bonding, and Principles
Authors: Corbett John D. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fine Tuning of Structure and Reactivity of Copper Complexes Using Pyridylalkylamine Ligands — Active Site Models for Copper Proteins
Authors: Itoh Shinobu 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthetic Chemistry of Halichlorine and the Pinnaic Acids
Authors: Clive Derrick L. J. , Yu Maolin , Wang Jian , Yeh Vince S. C. , Kang Shunzhen 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Natural tert‐Alkylamino Hydroxy Carboxylic Acids
Authors: Kang Sung Ho , Kang Suk Youn , Lee Hee‐Seung , Buglass Alan J. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of α‐Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
Authors: Sunazuka Toshiaki , Omura Satoshi 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Case Study in Biomimetic Total Synthesis: Polyolefin Carbocyclizations to Terpenes and Steroids
Authors: Yoder Ryan A. , Johnston Jeffrey N. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Magnetoresistive Sensors and Magnetic Nanoparticles for Biotechnology
Authors: Reiss Guenter , Brueckl Hubert , Huetten Andreas , Schotter Joerg , Brzeska Monika , Panhorst Michael , Sudfeld Daniela , Becker Anke , Kamp Paul B. , Puehler Alfred , et al. et al. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synchroton Radiation Circular Dichroism Spectroscopy of Proteins and Applications in Structural and Functional Genomics
Authors: Miles Andrew J. , Wallace B. A. 
Published: April 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Circulating levels and clinical significance of soluble CD40 in patients with hematologic malignancies
Authors: Hock Barry D. , McKenzie Judith L. , Patton Nigel W. , Drayson Mark , Taylor Karen , Wakeman Chris , Kantarjian Hagop , Giles Francis , Albitar Maher 
Published: April 2006

AbstractBACKGROUNDCD40 plays a critical role in immunoregulation, and CD40 ligation is being investigated as a therapy for hematologic malignancies. Although soluble CD40 (sCD40) is a potential modulator of both antitumor responses and CD40‐based therapies, the levels and significance of sCD40 in patients with hematologic malignancies are unknown.METHODSThe authors evaluated serum/plasma sCD40 levels using an enzyme‐linked immunoassay in patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and multiple myeloma (MM).RESULTSLevels of sCD40 were elevated in serum (>1.697 ng/mL) or plasma (>0.649 ng/mL) from 73% of patients with CLL, 80% of patients with MCL, 40% of patients with AML, 43% of patients with MDS, and 33% of patients with MM. Multivariate analysis of patients with MM demonstrated that elevated sCD40 was a significant, independent predictor of poor survival. In multivariate analysis of patients with AML, sCD40 was a significant prognostic factor when the interaction of age and sCD40 was included as a variable. Further analysis demonstrated that elevated sCD86 levels were associated with significantly shorter survival only in AML patients younger than age 64 years. Release of sCD40 by CLL cells was induced by cross‐linking with CD40 monoclonal antibody.CONCLUSIONSMany patients with hematologic malignancies have elevated circulating levels of sCD40, and these elevated levels are associated with a poor prognosis at least in patients with MM and AML, suggesting that sCD40 may have a role in modulating antitumor responses and also may be a useful prognostic marker. In addition, the findings suggested that further studies will be required to determine the effect of circulating sCD40 on the clinical effectiveness of CD40‐ligating reagents used in the treatment of hematologic malignancies. Cancer 2006. © 2006 American Cancer Society.
Maintenance therapy with thalidomide improves overall survival after autologous hematopoietic progenitor cell transplantation for multiple myeloma
Authors: Brinker Brett T. , Waller Edmund K. , Leong Traci , Heffner, Jr. Leonard T. , Redei Istvan , Langston Amelia A. , Lonial Sagar 
Published: April 2006

AbstractBACKGROUNDHigh‐dose chemotherapy with autologous hematopoietic progenitor cell (HPC) transplantation improves survival for patients with multiple myeloma (MM); however, most patients develop recurrent disease after undergoing transplantation, and new treatment approaches are needed. The objective of this retrospective review of autologous HPC transplantation for patients with MM was to evaluate the impact of conditioning regimens and posttransplantation therapy on survival.METHODSThe authors reviewed 112 patients with MM who received autologous HPC grafts at their institution. Between June 1992 and August 2001, 54 patients received busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP‐16), and 58 patients received high‐dose melphalan (MEL‐200) followed by autologous HPC transplantation. After transplantation, 36 patients received thalidomide for maintenance or salvage therapy, and 76 patients received no posttransplantation thalidomide.RESULTSAt a median follow‐up of 58 months, the median survival was 54 months. There was no statistically significant difference noted with regard to response to conditioning regimen, progression‐free survival, or overall survival between the Bu/Cy/VP‐16 and MEL‐200 cohorts. Patients who received thalidomide after transplantation had improved median survival (65.5 months) compared with patients who did not receive thalidomide (44.5 months; P = .09). When they were separated according to reasons for thalidomide use, patients who received thalidomide as maintenance had improved overall survival compared with patients who received thalidomide as salvage (65 months vs. 54 months; P = .05).CONCLUSIONSCombination chemotherapy provided no advantage over high‐dose melphalan in patients with MM who underwent autologous HPC transplantation. The posttransplantation use of thalidomide seemed to improve the survival of patients compared with historical controls from the prethalidomide era. Further prospective trials are underway to confirm the benefit of thalidomide in the posttransplantation setting. Cancer 2006. © 2006 American Cancer Society.
Exclusive mutation in epidermal growth factor receptor gene, HER‐2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
Authors: Suzuki Makoto , Shigematsu Hisayuki , Iizasa Toshihiko , Hiroshima Kenzo , Nakatani Yukio , Minna John D. , Gazdar Adi F. , Fujisawa Takehiko 
Published: April 2006

AbstractBACKGROUNDBoth genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event.METHODSMutations in the epidermal growth factor receptor gene (EGFR), HER‐2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data.RESULTSThirty‐nine EGFR, 4 HER‐2, and 6 KRAS mutations were found in 150 NSCLC cases, with the methylation percentages of the genes ranging from 13% to 54%. Most mutations were present in adenocarcinomas, but mutations of the 3 genes were never found to be present in individual tumors. The frequency of methylation for all the genes was correlated with the Methylation Index, a reflection of the overall methylation pattern (all genes, P≤.01), supporting the presence of the CpG island methylator phenotype (CIMP) in NSCLC. On the basis of the methylation profile, CRBP1 and CDH13 methylation were good indicators of CIMP in NSCLC, and were correlated with a poorer prognosis in adenocarcinomas. Mutations in EGFR, HER‐2, and KRAS were found to be present exclusively, whereas methylation tended to be present synchronously. A comparison of mutation and methylation demonstrated that the EGFR mutation had an inverse correlation with methylation of SPARC (secreted protein acidic and rich in cysteine), an extracellular Ca2+‐binding matricellular glycoprotein associated with the regulation of cell adhesion and growth, and the p16INK4A gene.CONCLUSIONSThe findings of the current study suggest that adenocarcinoma cases with CIMP have a poorer prognosis than adenocarcinoma cases without CIMP, and the EGFR mutation was shown to have an inverse correlation with methylation of SPARC and the p16INK4A gene in NSCLC. Cancer 2006. © 2006 American Cancer Society.
The methylation status and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma
Authors: Nakata Shoji , Sugio Kenji , Uramoto Hidetaka , Oyama Tsunehiro , Hanagiri Takeshi , Morita Masaru , Yasumoto Kosei 
Published: April 2006

AbstractBACKGROUNDAberrant methylation of the promoter CpG island (methylation) is known as a major inactivation mechanism of tumor suppressor and tumor‐related genes. In this study, the authors studied the presence of methylation by investigated the inactivation of genes and prognostic factors in patients with nonsmall cell lung carcinoma (NSCLC) by examining resection samples for the presence of methylation.METHODSSamples were obtained from 224 patients who underwent pulmonary resection for NSCLC. The authors used those samples to study methylation status with methylation‐specific polymerase chain reaction analysis and to study protein expression with immunohistochemistry for 3 different genes: CDH1, p16INK4A, and fragile histidine triad (FHIT).RESULTSThe frequency of methylation in NSCLC was determined as 58.0% for CDH1, 21.9% for p16INK4A, and 52.2% for FHIT. The methylation of p16INK4A was observed significantly in heavy smokers compared either with nonsmokers or with patients who had smoked for <20 pack‐years (P = .0420); it also was more significant in squamous cell carcinomas than in adenocarcinomas (P = .0343). FHIT methylation also was correlated significantly with lymph node metastasis (P = .0361). Patients who had tumors with both methylation and reduced expression of CDH1 had a significantly poorer prognosis compared with patients who had tumors both without methylation and with positive expression of CDH1 (P = .0259 and P = .0369, respectively; multivariate Cox analysis). For p16INK4A methylation, 63.3% of tumors showed reduced expression; whereas, in p16INK4A‐unmethylated tumors, 33.7% showed reduced expression (P = .0002). However, for CDH1 and FHIT, no significant correlation was found for either methylation or reduced expression.CONCLUSIONSAlthough protein expression was not inactivated by methylation alone, p16 expression was inactivated strongly by methylation. In addition, the analysis of methylation and expression of CDH1 played a clinically important role in treatment strategies for patients with NSCLC. Cancer 2006. © 2006 American Cancer Society.