bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Interstitial Lung Disease in Rheumatoid Arthritis by Thoracic Ultrasound: A Diagnostic Test Accuracy Study
Authors: Sofíudóttir Bjørk K. , Harders Stefan , Laursen Christian B. , Lage‐Hansen Philip R. , Nielsen Sabrina M. , Just Søren A. , Christensen Robin , Davidsen Jesper R. , Ellingsen Torkell 
Published: April 2024

ObjectiveTo determine the diagnostic accuracy of thoracic ultrasound (TUS) for detecting interstitial lung disease (ILD) in rheumatoid arthritis (RA) with respiratory symptoms.MethodsIndividuals with RA visiting rheumatologic outpatient clinics in the Region of Southern Denmark were systematically screened for dyspnea, cough, recurrent pneumonia, prior severe pneumonia, or a chest x‐ray indicating interstitial abnormalities. Eighty participants with a positive screening were consecutively included. Individuals were not eligible if they had a chest high‐resolution computed tomography (HRCT) less than 12 months ago or were already diagnosed with ILD. A blinded TUS expert evaluated TUS, and TUS was registered as positive for ILD if at least 10 B‐lines or bilateral thickened and fragmented pleura were present. The primary outcomes were TUS's sensitivity, specificity, and positive predictive value and negative predictive value. An ILD‐specialized thoracic radiologist assessed HRCT, followed by a multidisciplinary team discussion, which was the reference standard. The accepted window of HRCT was less than 30 days after TUS was performed.ResultsA total of 77 participants received HRCT less than 30 days after TUS, and 23 (30%) were diagnosed with ILD. TUS had a sensitivity of 82.6% (95% confidence interval [CI] 61.2%–95.0%) and a specificity of 51.9% (95% CI 37.8%–65.7%), corresponding to a positive predictive value of 42.2% (95% CI 27.7%–57.8%) and a negative predictive value of 87.5% (95% CI 71.0%–96.5%).ConclusionTo our knowledge, this prospective study is the first to use respiratory symptoms in RA as inclusion criteria. Systematic screening for respiratory symptoms combined with TUS can reduce the diagnostic delay of ILD in RA.image
Unraveling Enyne Bonding via Dehydrogenation–Hydrogenation Processes in On‐Surface Synthesis with Terminal Alkynes
Authors: Lyu Yuanhao , Gao Feng , Cheng Peng , Chen Lan , Klyatskaya Svetlana , Ruben Mario , Rosen Johanna , Barth Johannes V. , Björk Jonas , Wu Kehui , Zhang Yi‐Qi 
Published: April 2024

AbstractOn‐surface reactions of terminal alkynes in ultrahigh vacuum have attracted widespread attention due to their high technological promise. However, employing different precursors and substrate materials often intricate reaction schemes appear far from being well‐understood. Thus, recent investigations of alkyne coupling on noble metal surfaces suggest non‐dehydrogenative scenarios, contradicting earlier reports. Herein, the study employs noncontact atomic force microscopy (nc‐AFM) with high spatial resolution to conclusively characterize exemplary alkyne coupling products. Contrary to initial interpretations proposing dehydrogenative homocoupling on Ag(111), bond‐resolved AFM imaging reveals the expression of enyne motifs. Based on complementary, extensive density functional theory calculations, the pertaining reaction mechanisms are explored. It is proposed that enyne formation initiates with a direct carbon–carbon coupling between two alkyne groups, followed by surface‐assisted dehydrogenation‐hydrogenation processes. Thereby consecutive steps of atomic hydrogen cleavage, surface migration and recombination to a different carbon atom enable bridging via carbon–carbon double bonding. The new results shed light on subtle, but crucial surface‐mediated hydrogen transfer processes involved in the chemical bond formation, which are suggested to be of general relevance in on‐surface synthesis.
Concentration Recognition‐Based Auto‐Dynamic Regulation System (CRUISE) Enabling Efficient Production of Higher Alcohols
Authors: Chen Zhenya , Yu Shengzhu , Liu Jing , Guo Liwei , Wu Tong , Duan Peifeng , Yan Dongli , Huang Chaoyong , Huo Yi‐Xin 
Published: April 2024

AbstractMicrobial factories lacking the ability of dynamically regulating the pathway enzymes overexpression, according to in situ metabolite concentrations, are suboptimal, especially when the metabolic intermediates are competed by growth and chemical production. The production of higher alcohols (HAs), which hijacks the amino acids (AAs) from protein biosynthesis, minimizes the intracellular concentration of AAs and thus inhibits the host growth. To balance the resource allocation and maintain stable AA flux, this work utilizes AA‐responsive transcriptional attenuator ivbL and HA‐responsive transcriptional activator BmoR to establish a concentration recognition‐based auto‐dynamic regulation system (CRUISE). This system ultimately maintains the intracellular homeostasis of AA and maximizes the production of HA. It is demonstrated that ivbL‐driven enzymes overexpression can dynamically regulate the AA‐to‐HA conversion while BmoR‐driven enzymes overexpression can accelerate the AA biosynthesis during the HA production in a feedback activation mode. The AA flux in biosynthesis and conversion pathways is balanced via the intracellular AA concentration, which is vice versa stabilized by the competition between AA biosynthesis and conversion. The CRUISE, further aided by scaffold‐based self‐assembly, enables 40.4 g L−1 of isobutanol production in a bioreactor. Taken together, CRUISE realizes robust HA production and sheds new light on the dynamic flux control during the process of chemical production.
Near Infrared Light‐Emitting Diodes Based on Colloidal InAs/ZnSe Core/Thick‐Shell Quantum Dots
Authors: Roshan Hossein , Zhu Dongxu , Piccinotti Davide , Dai Jinfei , De Franco Manuela , Barelli Matteo , Prato Mirko , De Trizio Luca , Manna Liberato , Di Stasio Francesco 
Published: April 2024

AbstractHeavy‐metal‐free III–V colloidal quantum dots (QDs) exhibit promising attributes for application in optoelectronics. Among them, InAs QDs are demonstrating excellent optical performance with respect to absorption and emission in the near‐infrared spectral domain. Recently, InAs QDs attained a substantial improvement in photoluminescence quantum yield, achieving 70% at a wavelength of 900 nm through the strategic overgrowth of a thick ZnSe shell atop the InAs core. In the present study, light‐emitting diodes (LEDs) based on this type of InAs/ZnSe QDs are fabricated, reaching an external quantum efficiency (EQE) of 13.3%, a turn‐on voltage of 1.5V, and a maximum radiance of 12 Wsr−1m−2. Importantly, the LEDs exhibit an extensive emission dynamic range, characterized by a nearly linear correlation between emission intensity and current density, which can be attributed to the efficient passivation provided by the thick ZnSe shell. The obtained results are comparable to state‐of‐the‐art PbS QD LEDs. Furthermore, it should be stressed not only that the fabricated LEDs are fully RoHS‐compliant but also that the emitting InAs QDs are prepared via a synthetic route based on a non‐pyrophoric, cheap, and commercially available as precursor, namely tris(dimethylamino)‐arsine.
Bioinspired Mechanically Robust and Recyclable Hydrogel Microfibers Based on Hydrogen‐Bond Nanoclusters
Authors: Liang Jingye , Xu Jishuai , Zheng Jingxuan , Zhou Lijuan , Yang Weiping , Liu Enzhao , Zhu Yutian , Zhou Qiang , Liu Yong , Wang Run , Liu Zunfeng 
Published: April 2024

AbstractMechanically robust hydrogel fibers have demonstrated great potential in energy dissipation and shock‐absorbing applications. However, developing such materials that are recyclable, energy‐efficient, and environmentally friendly remains an enormous challenge. Herein, inspired by spider silk, a continuous and scalable method is introduced for spinning a polyacrylamide hydrogel microfiber with a hierarchical sheath‐core structure under ambient conditions. Applying pre‐stretch and twist in the as‐spun hydrogel microfibers results in a tensile strength of 525 MPa, a toughness of 385 MJ m−3, and a damping capacity of 99%, which is attributed to the reinforcement of hydrogen‐bond nanoclusters within the microfiber matrix. Moreover, it maintains both structural and mechanical stability for several days, and can be directly dissolved in water, providing a sustainable spinning dope for re‐spinning into new microfibers. This work provides a new strategy for the spinning of robust and recyclable hydrogel‐based fibrous materials.
Hardware Implementation of a Fully Functional Stochastic p‐STT Neuron for Probabilistic Computing
Authors: Jun Han‐Sol , Woo Dae‐Seong , Lee So‐Hyun , Choi Yohan , Shin Yeonsoo , Shim Tae‐Hun , Kim Jae‐Joon , Park Jea‐Gun 
Published: April 2024

AbstractA stochastic binary neuron is developed for probabilistic computing using a perpendicular spin‐transfer torque (p‐STT) neuron device and its associated peripheral circuits. The p‐STT neuron device, featuring a 300‐nm‐diameter pillar structure and a perpendicular magnetic‐tunnelling‐junction spin valve, is fabricated to exhibit stochastic switching behavior characterized by a sigmoidal function. The stochastic switching mechanism is influenced by the presence of defect sites within the device. The hardware implementation encompasses the construction of the neuron peripheral circuit, including the fire‐spike generation, sensing amplifier, and reset circuit, using a 28‐nm‐design‐rule complementary metal‐oxide‐semiconductor (C‐MOSFET) process. This hardware realization also demonstrates stochastic switching behavior with a sigmoidal function. However, a slight shift toward higher input voltage spike amplitudes is observed compared to the p‐STT neuron device alone, owing to voltage drop within the peripheral circuit. Furthermore, the software‐based investigation focuses on validating the feasibility of a spiking neural network. The temporal correlation detection is estimated using the stochastic switching probability derived from the hardware implementation, indicating successful synchronization between the correlated input neuron and the output p‐STT neuron.
Approach to Spirocyclohexadienes via Visible Light‐Mediated ipso‐Cyclization of Amino Acid Derivatives with N‐(2‐Phenyl)benzoyl Groups
Authors: Yoshida Yuki , Takeuchi Haruka , Arichi Norihito , Oishi Shinya , Ohno Hiroaki , Inuki Shinsuke 
Published: April 2024

AbstractSpirocycles are important structural motifs, found in natural and pharmaceutical compounds, which have attracted considerable interest in modern drug discovery research. Herein, we describe the development of a visible light‐mediated ipso‐cyclization of amino acid derivatives with N‐(2‐phenyl)benzoyl groups, allowing easy access to a variety of spirocyclohexadienes. The addition of water was found to be beneficial in promoting the reaction progress. Investigation of the substrate scope revealed that incorporating an electron‐donating moiety at the 3′‐position of the biphenyl group resulted in a more favorable outcome for spirocycle formation.
Synthesis of biomass‐derived ethyl levulinate from steam‐exploded corn straw
Authors: Zhao Haoran , Jia Yu , Chen Yihang , Liang Xuanyu , Hao Jinbo , Chen Binglin , He Chao , Liu Liang , Chang Chun , Xu Guizhuan 
Published: April 2024

AbstractEthyl levulinate (EL) production from steam‐exploded corn straw (SCS) in a cascade of reaction using a Brønsted (B) acid and a Lewis (L) acid in ethanol was studied. The entangled structure of corn straw could be obviously damaged through steam explosion when the pressure was 1.5 MPa holding 10 min. The content of cellulose can be increased from 35.9% to 46.8%, and the contents of hemicellulose and lignin were changed from 16.7% to 8.8% and 22.6% to 27.5%, respectively. EL yield was significantly increased from 10.7 to 24.6 wt% under optimal reaction conditions (L/B = 1/20 [mol/mol], 205°C, 90 min, 1.8 g of SCS, 60 mL of ethanol). According to kinetic models, the activation energies for the main and side reactions were 56.8 and 110.5 kJ mol−1, respectively. It suggested that SCS was more easily to be converted to EL rather than other by‐products. The highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) energy gaps (HOMO‐LUMO gaps) of cellobiose over the mixed acids in ethanol were significantly reduced with frontier molecular orbital (FMO) theory. This work provides an effective strategy for EL production from agricultural waste straws.
Isocyanate‐chitin modified microspheres for chiral drug separation in high performance liquid chromatography
Authors: Zhang Zhen , Wang Yue , Lv Shuai , Cong Hailin , Shen Youqing , Yu Bing 
Published: April 2024

AbstractIn this work, a two‐step activated swelling technique was effectively employed to successfully synthesize monodisperse porous poly(styrene‐divinylbenzene) (PS‐DVB) particles. Diazoresin (DR) transform an ionic bond into a covalent bond by photoreaction. Under ultraviolet irradiation, DR was used to covalently attach dichlorophenyl isocyanate to sulfonated PS‐DVB microspheres. The novel photo‐crosslinking reaction effectively overcomes the toxicity issues associated with conventional coupling agents and enables green production of chromatographic fillers. Modified PS‐DVB particles were indeed commonly used as filler material for the separation of chiral compounds by high performance liquid chromatography (HPLC). The porous modified microspheres designed effectively separate benzoone, DL‐mandelic acid, 2‐phenylcyclohexanone, ibuprofen, 2‐hydroxyl flavone, DL‐cysteine, chloraniline maleate, hesperidin, and other chiral compounds by 100 mm column. It is noteworthy that the isocyanate‐chitin modified microspheres are effective in separating chiral drugs (1000 μg/mL) within 5 min. Compared with ordinary microspheres, porous isocyanate‐chitin modified microspheres showed better separation efficiency under the same conditions. The enhancement is attributed to the increase in their specific surface area. Consequently, they are a better choice of chromatographic packing matrix.
Rainbow screening: Chromoproteins enable visualized molecular cloning
Authors: Ba Fang , Zhang Yufei , Liu Wan‐Qiu , Li Jian 
Published: April 2024

AbstractMolecular cloning facilitates the assembly of heterologous DNA fragments with vectors, resulting in the generation of plasmids that can steadily replicate in host cells. To efficiently and accurately screen out the expected plasmid candidates, various methods, such as blue‐white screening, have been developed for visualization. However, these methods typically require additional genetic manipulations and costs. To simplify the process of visualized molecular cloning, here we report Rainbow Screening, a method that combines Gibson Assembly with chromoproteins to distinguish Escherichia coli (E. coli) colonies by naked eyes, eliminating the need for additional genetic manipulations or costs. To illustrate the design, we select both E. coli 16s rRNA and sfGFP expression module as two inserted fragments. Using Rainbow Screening, false positive colonies can be easily distinguished on LB‐agar plates. Moreover, both the assembly efficiency and the construct accuracy can exceed 80%. We anticipate that Rainbow Screening will enrich the molecular cloning methodology and expand the application of chromoproteins in biotechnology and synthetic biology.
State diagrams of green peas (Pisum sativum L.) powders with different maltodextrin additions
Authors: Stępień Anna , Witczak Mariusz 
Published: April 2024

AbstractThe purpose of this study was to examine the effect of maltodextrin addition on the physical stability of powdered green peas. The evaluation of the physical state of the material was based on the equilibrium water content of the monolayer (Xm) and the glass transition temperatures of the powders at room temperature (Tg) and in the frozen state (Tg'). Graphical sorption characteristic at 25°C was determined using static—gravimetric method while capacity of the monolayer values was calculated from the mathematical GAB model. Differential scanning calorimetry was carried out in order to determine glass transition lines and freezing curves which combine together were used to plot state diagrams. Relationship between Tg and solid content were shown by using Gordon–Taylor model. Freezing data were modeled employing the Clausius–Clapeyron equation and its development—Chen model. Sorption isotherms showed sigmoidal shape characteristic for high‐molecular weight materials. Monolayer moisture content varied between 0.047 and 0.106 g water/g solids. The glass transition temperature of anhydrous green peas increased in from 89.9 to 175.6°C while Tg′ value changed from −43.4 to −26.6°C to as a result of 75% polysaccharide addition. The ultimate maximum‐freeze‐concentration conditions of the powders were observed in range from 0.783 to 0.814 g solids/g sample. Monolayer capacity, Tg and Tg′ values increased with increasing maltodextrin amount in the sample which indicates that the addition of starch hydrolysate has a beneficial effect on the stability of powders stored frozen and at room temperature.
Multicenter registry study of cerebral venous thrombosis in china (RETAIN‐CH): Rationale and design
Authors: Bian Hetao , Wang Xia , Liu Lan , Yan Feng , Lu Shan , Hui Wen , Zhou Chen , Duan Jiangang , Li Min , Chen Jian , Meng Ran , Cao Lei , Wang Longde , Ji Xunming 
Published: April 2024

AbstractBackground and rationaleCerebral venous thrombosis (CVT) is a rare cerebrovascular disorder that mainly affects young and middle‐aged adults. Epidemiological data on the incidence, risk factors, diagnosis, treatment, and prognosis of CVT are lacking in China. In addition, there is a lack of evidence from large, multicenter, real‐world studies on the efficacy and safety of endovascular.AimTo understand the incidence, diagnosis and treatment status of CVT in China and to estimate the effectiveness and safety of endovascular treatment in the real‐world.MethodsA multicenter, retrospective observational cohort study will be conducted on CVT patient records from 104 hospitals, between January 1, 2018 and June 30, 2022, identified using a 2‐stage cluster sampling design based on per capita gross domestic product. Each enrolled participant is required to complete a further follow‐up, which includes the current situation and the assessment at 3 and 12 months after discharge.Study outcomesThe outcomes of this study will include the current status of the incidence, pathogenesis, etiology, clinical symptoms, diagnosis, and treatment of CVT in China, as well as the effectiveness and safety of endovascular treatment in the real‐world.DiscussionResults from this study will provide evidence on the incidence, specific risk factors, symptomatic and imaging features, and clinical outcomes of CVT in China as well as indicate whether endovascular treatment is superior to medical management alone for patients with acute CVT in the real‐world.Trial registrationhttp://www.clinicaltrials.gov.IdentifierNCT05448248
Prognostic value of cardiovascular magnetic resonance in immune checkpoint inhibitor‐associated myocarditis: A systematic review and meta‐analysis
Authors: Song Wenhua , Zhang Nan , Lv Tonglian , Zhao Yang , Li Guangping , Tse Gary , Liu Tong 
Published: April 2024

AbstractBackgroundImmune checkpoint inhibitors (ICI) are increasingly used in the first‐line treatment of malignant tumors. There is increasing recognition of their cardiotoxicity and, in particular, their potential to lead to myocarditis. Cardiovascular magnetic resonance (CMR) can quantify pathological changes, such as myocardial edema and fibrosis. The purpose of this systematic review and meta‐analysis was to examine the evidence for the roles of CMR in predicting prognosis in ICI‐associated myocarditis.MethodsPubMed, Cochrane Library, and Web of Science databases were searched until October 2023 for published works investigating the relationship between CMR parameters and adverse events in patients with ICI‐associated myocarditis. The analysis included studies reporting the incidence of late gadolinium enhancement (LGE), T1 values, T2 values, and CMR‐derived left ventricular ejection fraction (LVEF). Odds ratios (OR) and weighted mean differences (WMD) were combined for binary and continuous data, respectively. Newcastle‐Ottawa Scale was used to assess the methodological quality of the included studies.ResultsFive cohort studies were included (average age 65–68 years; 25.4% female). Of these, four studies were included in the meta‐analysis of LGE‐related findings. Patients with major adverse cardiovascular events (MACE) had a higher incidence of LGE compared with patients without MACE (OR = 4.18, 95% CI: 1.72–10.19, p = 0.002). A meta‐analysis, incorporating data from two studies, showed that patients who developed MACE exhibited significantly higher T1 value (WMD = 36.16 ms, 95% CI: 21.43–50.89, p < 0.001) and lower LVEF (WMD = − 8.00%, 95% CI: −13.60 to −2.40, p = 0.005). Notably, T2 value (WMD = −0.23 ms, 95% CI: −1.86 to −1.39, p = 0.779) was not associated with MACE in patients with ICI‐related myocarditis.ConclusionsLGE, T1 value, and LVEF measured by CMR imaging have potential prognostic value for long‐term adverse events in patients with ICI‐related myocarditis.
The Capacity of Alkali‐Activated Industrial Wastes in Novel Sustainable Ceramic Membranes
Authors: Shiwa Sina , Khosravi Arash , Mohammadi Farzaneh , Abbasi Mohsen , Sillanpää Mika 
Published: April 2024

AbstractNovel ceramic membranes present unquestionable potential in wastewater treatment among the emerging technologies, while a few challenges such as cost, energy consumption, durability, and resistance in harsh mediums still limit their commercialization. Here, we review the capability of available industrial aluminosilicate waste materials in the fabrication of novel ceramic membranes using green and economical alkali‐activation synthesis method. The different sources of alkali‐activated aluminosilicate wastes including ashes, mining wastes, glass and ceramic wastes, slags, construction wastes, industrial byproducts, and agricultural wastes are introduced and the chemistry of geopolymers is reviewed. In this review, the major points are the following. 1) The alkali‐activated structures present reasonable chemical, frost, carbonation, and mechanical resistance as well as the ability to immobilize the toxic materials. 2) The synthesis aspects of porous and nonporous alkali‐activated ceramic membranes are explored by characterization methods. Furthermore, the durability analysis in harsh environments reveals that alkali‐activated ceramic membranes possess high resistance against acidic, alkaline, and other antifouling chemical washing methods. In summary, it is demonstrated that the studied membranes have an undeniable capability in the separation of organic solvents in the pervaporation process as well as toxic material removal from water with high ion‐exchange capacity.