bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statins and Venous Thromboembolic Disease – Where are we Now?
Authors: Poredoš Pavel , Mukherjee Debabrata , Blinc Aleš 
Published: March 2024

:
Classical risk factors for atherosclerosis also play a role in the pathogenesis of venous
thromboembolism (VTE). Low-density lipoprotein cholesterol has prothrombotic and endothelium-
deteriorating effects which are not limited to the arterial system. The association between hypercholesterolemia
and VTE has been established, but the benefits of statins in the prevention of
VTE assessed by observation studies seemed equivocal. The large, randomized trial Justification
for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) recorded
the occurrence of VTE as a protocol-specified endpoint and reported a reduced incidence
of VTE among subjects taking 20 mg of rosuvastatin daily vs placebo (hazard ratio 0.57; 95% confidence
interval 0.37-0.86; p=0.007). Similar results were confirmed by meta-analyses of observation
studies and randomized trials. Recently, a Mendelian randomization study that took the presence
of gene variants coding for less efficient hydroxymethyl-glutaryl coenzyme A reductase activity
as a proxy for statin treatment, confirmed a small, but significant negative association between
the score of selected genetic polymorphisms and the incidence of VTE. However, since the
protective effects of statins are limited, they should not be substituted for guideline-recommended
VTE prophylaxis or anticoagulation treatment.
Design and Synthesis of Novel Anti-proliferative Formononetin Derivatives
Authors: Luo Zeping , Pan Liwei , Yin XiuJu , Chen Hailin 
Published: March 2024

Background:
This study aimed to design and synthesize a series of novel C8-
Formononetin derivatives and evaluate their in vitro anti-tumor activity. The experimental results
showed that these derivatives exhibited varying degrees of anti-tumor effects on HeLa, A549, and
HepG2 cells, and compound 8, in particular, showed excellent inhibitory activity against HepG2 cell
growth, which surpassed that of 5-FU.

Methods:
Importantly, the cytotoxicity of FMN was significantly enhanced after conjugation with
amino acid ethyl ester. To further investigate the mechanisms underlying the anti-tumor effects of
these derivatives, various experimental approaches were employed. They include colony formation
assay, EdU cell proliferation assay, Transwell migration assay, cell apoptosis assay, cell cycle distribution
assay, and ELISA.

Results:
The results revealed that compound 8 effectively induced cell apoptosis by downregulating
the expression of anti-apoptotic proteins P53, Bcl-2, and Mcl-1 while upregulating the expression of
pro-apoptotic proteins Bax, Fas, Caspase-3, Caspase-9, and Fas, which leads to apoptosis of tumor
cells. Furthermore, compound 8 disrupted the mitochondrial membrane potential, perturbed cellular
energy metabolism, and reduced intracellular ATP levels, thereby inhibiting tumor cell growth.

Conclusion:
The newly synthesized FMN derivatives in this study hold great potential in the field of
anti-tumor research. Compound 8 inhibits tumor cell growth through multiple pathways, which provides
new hope for cancer treatment.
Exploring the Pharmacological Potential of Lobelia trigona and its
Bioactive Compounds
Authors: Moharana Ankita , Choudhury Priyabati , Behera Snigdha Rani , Vishwakarma Pratik Kumar , Tripathi Shivendra Mani , Srivastava Shobhit Prakash 
Published: March 2024

Aim::
The aim of this in-depth review is to provide an overview of the pharmacologi-cal effects of Lobelia trigona and its bioactive components, highlighting its potential as a source of medicinal agents for various diseases

Methods::
This review involved a comprehensive analysis of existing literature and research studies on the pharmacological effects of Lobelia trigona and its bioactive compounds. A bib-liography survey was carried out using various electronic databases like Google Scholar, Sci-enceDirect, Springer, Scopus, PubMed, Wiley, etc., and other offline as well as online aca-demic libraries were also used for the bibliography survey and compilation of data.

Results::
Lobelia trigona was found to exhibit diverse pharmacological effects, primarily me-diated by bioactive alkaloids, such as lobeline, lobelanidine, and lobelanine. It demonstrated bronchodilator effects with potential applications in respiratory conditions, analgesic and anti-inflammatory properties for treating painful and inflammatory conditions, and cardiovascular effects, including vasodilation and hypotensive effects. The alkaloid lobeline was reported to have promising anti-addictive effects, particularly in smoking cessation. Nanocarrier-based formulations have the potential to address limitations, improve dosing schedules, and enhance the pharmacological effects of Lobelia trigona.

Conclusion::
Lobelia trigona demonstrates diverse pharmacological effects, primarily attribut-ed to its bioactive alkaloids. It holds promise as a source of medicinal agents for a range of diseases. The potential synergy between the pharmacological effects of Lobelia trigona and nanocarrier technology highlights the significance of nanotechnology in improving Lobelia trigona-based therapeutics. However, further research is warranted to determine the clinical effectiveness, safety, biocompatibility, and long-term effects of nanocarrier-based Lobelia trigona formulations in different disease models.
Penerapan Healthcare Failure Mode and Effect Analysis (HFMEA) pada Implementasi Rekam Medis Elektronik
Authors: Yudianti Ellya - , Arini Merita - 
Published: March 2024

Latar Belakang: Rekam Medis Elektronik (RME) terbukti meningkatkan kualitas layanan kesehatan. Namun, penerapannya belum mencapai target yang diharapkan, berisiko terhadap kepuasan dan keselamatan pasien, bahkan terancam gagal. Rumah sakit harus mengelola berbagai risiko pada penerapan RME untuk mencapai tujuannya.Tujuan: Penelitian ini bertujuan untuk mengidentifikasi dan menilai risiko-risiko penerapan RME, serta menyusun strategi pengendaliannya. Metode: Penelitian ini menggunakan metode kualitatif dengan pendekatan partisipatif dan menerapkan Healthcare Failure Mode and Effect Analysis di sebuah rumah sakit swasta, melalui Consensus Decision-Making Group.Hasil: Penelitian ini mengidentifikasi 51 risiko penerapan RME, dengan 49 di antaranya yang diproses dan dikelompokkan menjadi 5 tema, yaitu kebijakan penggunaan RME, subjek RME, kualitas sistem RME, infrastruktur, dan komunikasi. Penilaian risiko bervariasi dari risiko rendah sampai sangat tinggi. Perhatian petugas masih berfokus pada kelengkapan data dan sistem yang berjalan, tetapi keamanan data belum menjadi perhatian. Penelitian ini merumuskan 16 rencana pengendalian risiko dengan 3 prioritas yang direkomendasikan, yaitu menyusun kebijakan dan pedoman implementasi RME, pelatihan secara hands-on kepada dokter, dan pembaruan sistem RME berkala serta menyusun co-creation tentang penambahan fitur sistem RME. Kesimpulan: Penerapan RME tidak terlepas dari risiko kegagalan. HFMEA mampu memotret hal ini dengan menggali potensi kesalahan. Diperlukan uji coba implementasi rekomendasi strategi perbaikan untuk mencegah kegagalan.
Edad materna avanzada y su asociación con resultados materno- perinatales en gestantes de un hospital público en Santiago de Chile
Authors: Ortiz Jovita , Villanueva-Pavón Loreto , Ortega-Colihuinca Camila , Mellado-López Fernanda 
Published: March 2024

Introducción: Chile es un país Latinoamericano en etapa IV de transición obstétrica, con gestaciones en edad materna avanzada (EMA), lo cual podría influir en resultados maternos y perinatales. Objetivo: Determinar la prevalencia de gestantes en EMA y su asociación con resultados maternos y perinatales en gestantes de un hospital público en Santiago de Chile entre enero y julio, 2017. Material y Métodos: Estudio transversal analítico, en 2362 gestantes de un hospital público de Santiago. Datos obtenidos de base autorizada por comité de ética. Se realizó un análisis comparativo, mediante Stata 14.0. Se utilizó Chi cuadrado para analizar las variables cualitativas y se consideró un valor de p<0,05 como estadísticamente significativo. Se calculó OR con un IC de 95%. Resultados: El promedio de edad de las gestantes con EMA fue de 37,9 ± 2,59. La EMA se asoció con escolaridad <12 a años de estudio, encontrarse con pareja, obesidad al ingreso de la atención prenatal y al momento del parto, hipertensión arterial, diabetes pregestacional y gestacional, multiparidad, y síndrome hipertensivo inducido por el embarazo. Asimismo, tuvieron más probabilidad de cesárea, presentar parto prematuro e hijos con bajo peso al nacer. Las mujeres sin EMA, tuvieron mayor probabilidad de estar con sobrepeso. Conclusión: Si bien las mujeres con EMA tienen condiciones maternas y perinatales acordes a la etapa de transición obstétrica avanzada, se requiere también atención de las mujeres sin EMA ya que presentan estados de sobrepeso que dan cuenta de un acelerado avance a un perfil nutricional de mayor riesgo perinatal.
Forensic seismic evidence for precursory mobilization in Gaza leading to the October 7 terrorist attack
Authors: Inbal Asaf 
Published: March 2024

Seismic waves excited by human activity frequently mask signals due to
tectonic processes, and are therefore discarded as nuisance. Seismic
noise-field analysis is, however, a powerful tool for characterizing
anthropogenic activities. Here, I apply this analysis to examine seismic
precursors to the October 7 Hamas attack on Israel. The precursory
activity in Gaza included massive mobilization which took place in the
hours leading to the attack, and was documented on multiple media
outlets. Favorable conditions, which arise due to a temporary lack of
anthropogenic activity in Israel, allow remote seismic stations to
record signals due to Gaza vehicle traffic. I use these seismograms to
identify anomalous ground-motions, associate them with pre-attack
mobilization, and precisely determine their location. By applying array
analysis to three seismic stations located tens-of-kilometers from the
Gaza Strip, I was able to obtain valuable information on the Hamas
attack plans. This suggests that embedding seismic noise-field analysis
into decision-making protocols could enhance preparedness, thus
providing an opportunity to blunt terrorist attacks and reduce the
number of casualties.
The Effectiveness of Obstetric Emergency Interventions in Enhancing Mother and Fetal Well-Being: A Systematic
Authors: Imansari Bhekti , Nurhidayah Ida , Rahmawati Ai , Pawestri Risang , Hemedes Camilie G. 
Published: March 2024

An obstetric emergency is a condition that can threaten the life of a pregnant woman and the fetus, which occurs during pregnancy, childbirth and the puerperium. This review aimed to analyze the effectiveness of emergency obstetric interventions based on previous studies. The study was a systematic review carried out in seven stages through three databases from Ebsco, Pubmed and Proquest. The keywords used were (pregnant women) AND (emergency intervention) AND (nursing OR nurse) NOT (systematic review). The inclusion criteria in this study were: full-text, peer review, English, articles for the last five years, subject: nursing, nurses, emergency medical care, nursing care, emergency services, and document type: articles. Based on the search database, 10,496 papers were obtained, 733 documents that matched the inclusion criteria and seven papers that fit the theme were obtained. The result that based on the initial stage of the literature search, four interventions were adequate, including ACLS training, multidisciplinary management, making coloured ribbons for premature pregnancy detection, and maternal near-miss detection tools. Interventions with less effective based on statistical test results were supportive care, home visits with IPV (intimate partner violence) interventions, and administration of CPR, defibrillation, ETT insertion, and administration of epinephrine. Nurses still carry out a few emergency developmental interventions. It is necessary to develop engagement interventions related to maternal emergencies to improve the welfare of mothers and babies. Further study is needed to strengthen the evidence base of innovative interventions for specific obstetric emergencies.
Validity and Reliability Study of the Indonesian Student Satisfaction with Cultural Simulation Experiences Scale (SCSES) among Nursing Students
Authors: Rahmawati Sephia , Pramukti Iqbal , Rosidin Udin 
Published: March 2024

Virtual Reality is a technology that can simulate a virtual environment like a real one and make it seem like if users can interact in it. The development of learning to use Virtual Reality has begun to be used as a medium for learning skills to increase students' clinical knowledge and reasoning in nursing practice, so that students can show reasonable learning satisfaction in the learning process. Student satisfaction is needed to determine the effectiveness of using VR in nursing practice. Satisfaction with using virtual reality for student learning experiences can be evaluated using the SCSES (Student Satisfaction with Cultural Simulation Experience Scale), but there is no Indonesian language version for this instrument. This study aimed to translate and adapt the SCSES (Student Satisfaction with Cultural Simulation Experience Scale) instrument in the Indonesia context for nursing students. Methods: The SCSES translation uses the cross-sectional method and in the translation process refers to the five stages of international standard guidelines for translation. Results: The reliability and validity test of the SCSES instrument was tested on 92 Padjadjaran University nursing students. Confirmatory Factor Analysis (CFA) was carried out to measure construct validity. It was found that all items of the Indonesian version of the SCSES instrument were declared valid with the value of all factor loading items > 0.50 and the Cronbach's α test was performed to measure the consistency of measurements (α = 0.964). Conclusions: The Indonesian version of SCSES has good item validity and reliability as a measure of satisfaction in cultural simulation experiences. .
PERSEPSI DOSEN FAKULTAS USHULUDDIN ADAB DAN DAKWAH TERHADAP PEMBELAJARAN DARING SELAMA PANDEMI COVID-19 DI IAIN PALOPO
Authors: AGUSTAN AGUSTAN AGUSTAN 
Published: March 2024

Pembelajaran secara daring dan bekerja dari rumah merupakan kebijakan yang dikeluarkan oleh pemerintah khususnya Kementerian Agama RI dalam upaya meminimalisir terjadinya penyebaran dan penularan Covid-19 termasuk di lingkungan Perguruan Tinggi Islam Negeri. Tujuan dalam penelitian ini untuk mengetahui bagaimana perspepsi dosen Fakultas Ushuluddin Adab dan Dakwah IAIN Palopo terhadap pembelajaran daring di masa pandemi Covid-19. Penelitian ini dilakukan dengan menggunakan metode survei deskriptif dengan menggunakan simple random sampling di mana sampel dalam penelitian ini sebanyak 21 dosen. Teknik pengumpulan data menggunakan angket (quesioner) melalui google form kepada dosen yang telah melaksanakan pembelajaran daring. Hasil penelitian menunjukkan bahwa jenis media pembelajaran yang paling banyak digunakan dalam pembelajaran daring yaitu Whatsapp group, Pelaksanaan perkuliahan daring pada umumnya dilaksanakan di lokasi kampus IAIN Palopo, Metode perkuliahan daring dengan menggunakan tatap muka secara langsun melalui aplikasi video converence, Kendala yang dihadapi dosen dalam melaksanakan perkuliahan daring yaitu kesulitan dalam menyampaikan materi, Keluhan mahasiswa dalam pembelajaran daring yaitu kesusahan meminta toleransi kepada dosen dengan alasan jaringan buruk, dan perkuliahan daring kadang-kadang efektif dilaksanakan oleh dosen di masa pandemi Covid-19.
Efektivitas Media Audio Visual dalam Pembelajaran PAI Daring di MTs Negeri 9 Yogyakarta
Authors: Ilmi Munaya Ulil , Kurniawan Muh. Alif 
Published: March 2024

The purpose of this study was to determine the effectiveness of learning using audio-visual media, especially in Islamic religious education subjects at MTs Negeri 9 Yogyakarta. This research is a quantitative descriptive research that uses a survey method. The data collection used is using a survey with a Likert scale. In analyzing the data, the researcher calculated the percentage in each of the existing indicators. The results of this study indicate that the effectiveness of using audio-visual media at MTs Negeri 9 Yogyakarta is included in the "Very Good" criteria with an average percentage of 84.85%. Even though the criteria achieved were good, the researcher still got some difficulties faced by the students. This difficulty needs to get solutions and handling from the school so that the implementation of learning becomes more perfect and can achieve educational goals as well as possible. The audio-visual media used needs to be carefully designed according to the needs and abilities of the students. The research results that have been obtained are expected to be considered in evaluating learning and become a reference for future research. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas pembelajaran yang memanfaatkan media audio visual khususnya dalam mata pelajaran pendidikan agama Islam di MTs Negeri 9 Yogyakarta. Penelitian ini merupakan penelitian deskriptif kuantitatif yang menggunakan metode survei. Pengumpulan data yang digunakan adalah menggunakan survei dengan skala likert. Dalam menganalisis data, peneliti menghitung presentase dalam setiap indikator yang ada. Hasil penelitian ini menunjukkan bahwa efektivitas penggunaan media audio visual di MTs Negeri 9 Yogyakarta termasuk dalam kriteria “Sangat Baik” dengan rata-rata presentase 84,85%. Meskipun kriteria yang dicapai telah baik, peneliti masih mendapatkan beberapa kesulitan yang dihadapi siswa. Kesulitan ini perlu mendapatkan solusi dan penanganan dari pihak sekolah agar pelaksanaan pembelajaran menjadi lebih sempurna dan dapat meraih tujuan pendidikan dengan sebaik-baiknya. Media audio visual yang digunakan perlu dirancang dengan matang sesuai dengan kebutuhan dan kemampuan yang dimiliki oleh para siswa. Hasil penelitian yang telah didapatkan diharapkan mampu menjadi bahan pertimbangan dalam melakukan evaluasi pembelajaran dan menjadi referensi bagi penelitian di masa depan.
Textile Dye Adsorption by Natural Perlite
Authors: Bekheira Samir , Youcef Djamel Ould , Nabil Beloufa , Abdelkader Bouhenna , Kada Boualem , Hamadache Miloud 
Published: March 2024

Abstract
In today's world of industrial progress, pollution is a major concern, especially water pollution. Considered a real danger to mankind, this article looks at the treatment of water contaminated by textile dyes, which has become a danger to humans and the environment. As an example, we have chosen the green dye FB (anionic type) which is found in the rejects of a textile factory ENADITEX in the industrial zone of the wilaya of ORAN - ALGERIA, this dye is among the most used in the textile industry. The method adopted for dye removal is adsorption by natural perlite. The Experimental results showed that adsorption of the green dye FB on the porous solid studied: natural perlite, gave a removal rate of 87.51% for 60 minutes. The adsorption isotherms of the adsorbent/adsorbate systems studied are satisfactorily described by the two mathematical models Freundlich and Temkin. All the results obtained show that the adsorption kinetics of the green dye FB by the solid material is well described by the second-order model. The adsorption reaction is a physisorption, as the thermodynamic study demonstrated.
The Effect of Microfinance Banks on Poverty Reduction in Nigeria
Authors: Onyele Kingsley Onyekachi , Onyekachi-Onyele Charity 
Published: March 2024

Abstract
The nexus between microfinance banking and poverty reduction is well documented in banking and finance literature. As a poverty reduction strategy, the microfinance initiative is expected to create room for financial accessibility to the economically active poor people. Consequently, this study estimated the effect of microfinance banks’ (MFBs) on poverty reduction in Nigeria from 1992 to 2018 using the Autoregressive Distributed Lag (ARDL) approach to regression analysis. With a VAR lag order selection of two, the ARDL bounds test revealed that the poverty rate and MFBs activities were bound by a long-run relationship. The long-run estimates suggested that the MFBs loans-to-deposit ratio and liquidity ratio caused poverty reduction in the long-run. On the other hand, the short-run estimates indicated that the MFBs were unable to ensure poverty reduction within a short period, though all the variables exhibited significant coefficients within one year. These findings imply that the ability of MFBs to reduce poverty takes a long period.
Mexican Researchers’ Contributions to the World Scientific Publications
Authors: Lopez-Leyva Santos 
Published: March 2024

Abstract
This paper highlights the importance of Mexican researchers’ scientific publications in journals that are listed in Scopus and Web of Sciences (WoS). This research found that 98% of these publications were written by members of the National System of Researchers (SNI, by its acronym in Spanish), hence the importance of strengthening this organization. The paper also analyses the evolution of the funds that have been invested in science and technology; financing represented only 0.40% of the GDP (Gross Domestic Product) from 2000 to 2017. Therefore, it is concluded that such a variable is not determining enhancing scientific production among Mexican researchers. It is stated that per capita income growth within a country could improve the conditions for scientific production; however, in Mexico, this indicator was barely 0.8% annually; therefore, it is not a significant variable regarding the growth of Mexican publications. Mexico has gained importance in world science, explained by a growth in the number of researchers and their willingness to participate in the production of knowledge.
The Emergence of Knowmads from the Knowledge Workers
Authors: Iliescu Andra Nicoleta 
Published: March 2024

Abstract
The purpose of this paper is to contribute to the academic advances in the knowledge management field, by increasing the understanding of the knowmad workforce. Knowledge economy represents the context in which organizations and individuals strive to learn continuously, to remain competitive, and to reach success. In this context, knowledge management joins other management specializations in the dedicated quest of optimizing organizational knowledge dynamics. Over the past decades, in close connection with unpredictable developments in all facets of our lives, which impact the business environment as well, a new typology of workers is being recognized in the knowledge management literature. The knowmads are emerging from the knowledge workers in a context of an intensified knowledge economy and they are developing skills and competencies that are suitable for the global markets, becoming autonomous, innovative, highly adaptable, and entrepreneurial members of the organizations, as this study proves. The research objective of this paper is to find and analyze the core conditions that favor the emergence of the knowmads from the knowledge workers. Through extensive literature review and by using data analysis software, key concepts are identified in close relation with knowmads. In the first part the intensification of the knowledge economy in Society 3.0 is analyzed from a critical perspective while, in the second part, the significant skills and competencies shift is being discussed. The working hypothesis of this research is that knowmads represent a new type of knowledge worker. Therefore, a comparison between the two worker groups from a skill, competencies, and attributes perspective was also implemented for increased methodological coherence. As this paper shows, in the intensified and global knowledge economy environment and under the forces of digitalization, technologization, new key competencies become essential within organizations. The holders of these competencies prove to be the knowmads, the new workers’ group emerging from the knowledge workers in the late 21st century.