bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening and identification of lncRNAs in preadipocyte differentiation in sheep
Authors: Hao Zhiyun , Jin Xiayang , Hickford Jon G. H. , Zhou Huitong , Wang Longbin , Wang Jiqing , Luo Yuzhu , Hu Jiang , Liu Xiu , Li Shaobin , Li Mingna , Shi Bingang , Ren Chunyan 
Published: March 2024

AbstractStudies of preadipocyte differentiation and fat deposition in sheep have mainly focused on functional genes, and with no emphasis placed on the role that long non-coding RNAs (lncRNAs) may have on the activity of those genes. Here, the expression profile of lncRNAs in ovine preadipocyte differentiation was investigated and the differentially expressed lncRNAs were screened on day 0 (D0), day 2(D2) and day 8(D8) of ovine preadipocyte differentiation, with their target genes being predicted. The competing endogenous RNA (ceRNA) regulatory network was constructed by GO and KEGG enrichment analysis for functional annotation, and some differentially expressed lncRNAs were randomly selected to verify the RNA-Seq results by RT-qPCR. In the study, a total of 2517 novel lncRNAs and 3943 known lncRNAs were identified from ovine preadipocytes at the three stages of differentiation, with the highest proportion being intergenic lncRNAs. A total of 3455 lncRNAs were expressed at all three stages of preadipocyte differentiation, while 214, 226 and 228 lncRNAs were uniquely expressed at day 0, day 2 and day 8, respectively. By comparing the expression of the lncRNAs between the three stages of differentiation stages, a total of 405, 272 and 359 differentially expressed lncRNAs were found in D0-vs-D2, D0-vs-D8, and D2-vs-D8, respectively. Functional analysis revealed that the differentially expressed lncRNAs were enriched in signaling pathways related to ovine preadipocyte differentiation, such as mitogen-activated protein kinase (MAPK) pathway, the phosphoinositide 3-kinase protein kinase B (PI3K-Akt) pathway, and the transforming growth factor beta (TGF-β) pathway. In summary, lncRNAs from preadipocytes at different stages of differentiation in sheep were identified and screened using RNA-Seq technology, and the regulatory mechanisms of lncRNAs in preadipocyte differentiation and lipid deposition were explored. This study provides a theoretical reference for revealing the roles of lncRNAs in ovine preadipocyte differentiation and also offers a theoretical basis for further understanding the regulatory mechanisms of ovine preadipocyte differentiation.
Pan-cancer integrated analysis of ANKRD1 expression, prognostic value, and potential implications in cancer
Authors: Xu Xusan , Zhong Dan , Wang Xiaoxia , Luo Fei , Zheng Xiaomei , Feng Taoshan , Chen Riling , Cheng Yisen , Wang Yajun , Ma Guoda 
Published: March 2024

AbstractThere is substantial evidence demonstrating the crucial role of inflammation in oncogenesis. ANKRD1 has been identified as an anti-inflammatory factor and is related to tumor drug resistance. However, there have been no studies investigating the prognostic value and molecular function of ANKRD1 in pan-cancer. In this study, we utilized the TCGA, GTEx, GSCALite, ENCORI, CTRP, DAVID, AmiGO 2, and KEGG databases as well as R language, to explore and visualize the role of ANKRD1 in tumors. We employed the ROC curve to explore its diagnostic significance, while the Kaplan–Meier survival curve and Cox regression analysis were used to investigate its prognostic value. Additionally, we performed Pearson correlation analysis to evaluate the association between ANKRD1 expression and DNA methylation, immune cell infiltration, immune checkpoints, TMB, MSI, MMR, and GSVA. Our findings indicate that ANKRD1 expression is dysregulated in pan-cancer. The ROC curve revealed that ANKRD1 expression is highly sensitive and specific in diagnosing CHOL, LUAD, LUSC, PAAD, SKCM, and UCS (AUC > 85.0%, P < 0.001). Higher ANKRD1 expression was related to higher overall survival (OS) in LGG, but with lower OS in COAD and STAD (P < 0.001). Moreover, Cox regression and nomogram analyzes suggested that ANKRD1 is an independent factor for COAD, GBM, HNSC, and LUSC. Dysregulation of ANKRD1 expression in pan-cancer involves DNA methylation and microRNA regulation. Using the CTRP database, we discovered that ANKRD1 may influence the half-maximal inhibitory concentration (IC50) of several anti-tumor drugs. ANKRD1 expression showed significant correlations with immune cell infiltration (including cancer-associated fibroblast and M2 macrophages), immune checkpoints, TMB, MSI, and MMR. Furthermore, ANKRD1 is involved in various inflammatory and immune pathways in COAD, GBM, and LUSC, as well as cardiac functions in HNSC. In vitro experiments demonstrated that ANKRD1 promotes migration, and invasion activity, while inhibiting apoptosis in colorectal cancer cell lines (Caco2, SW480). In summary, ANKRD1 represents a potential prognostic biomarker and therapeutic target in human cancers, particularly in COAD.
An improved finegrained ciphertext policy based temporary keyword search on encrypted data for secure cloud storage
Authors: Dabra Mamta , Sharma Shivani , Kumar Sachin , Min Hong 
Published: March 2024

AbstractWe present a temporary keyword search over sensitive and confidential health data in a cloud environment. The cloud constitutes a semi-trusted domain, making it necessary for data owners to secure their data before outsourcing it through techniques like encryption. Attribute-based keyword search techniques tend to perform a search operation using a search token generated by an authorized user. These search tokens can lead to serious privacy threats, as they can extract all ciphertexts that may have been generated along with their keyword. Therefore, restricting search tokens to extract ciphertexts generated within a time interval is a more promising solution. In this paper, we present a novel ciphertext policy fine-grained temporary keyword that prevents the misuse of these search tokens. Further, it mitigates the risk of insider threats within healthcare organizations by limiting the window of opportunity for unauthorized access to minimum. To assess the security, our proposed scheme is formally proven to be secure against Selectively Chosen Keyword Attacks in the generic bilinear group model. Additionally, we demonstrate that the encryption algorithm’s complexity is linear in relation to the number of attributes. Our scheme’s significance and practicality are revealed by the performance evaluation.
Effect of information provision on parental intention toward COVID-19 vaccination for children: a nationwide survey experiment
Authors: Lee Hyunju , Park Jung Hyun , Kim Shinkyeong , Seo Sujin , Lee Minjung , You Myoungsoon , Choi Eun Hwa , Kwon Geun-Yong , Shin Jee Yeon , Lee Min-Ah , Jeong Mi Jin , Choe Young June , Choi Syngjoo 
Published: March 2024

AbstractThe reluctance of parents to vaccinate their children against COVID-19 was prevalent particularly when uncertainty over vaccination outcomes prevailed. We conducted a nationwide randomized online survey experiment to assess the effect of information provision on parental intention for COVID-19 vaccination before the government started vaccination for children in South Korea. Parents of elementary school children were provided with either no information (Control), information on vaccine profile (vaccine informed group; VI), or COVID-19 (disease informed group; DI). Among 359,110 participants, parental intention for vaccination of children was significantly higher in both VI and DI groups compared with the Control group. In terms of effect size, information on COVID-19 vaccine increased likelihood to vaccinate by 1620 per 100,000 parents and reduced vaccine hesitancy by 1340 per 100,000 parents. Consistently with the positive effect on vaccination intention, both VI and DI interventions increased participants’ perceptions on vaccination benefits being higher than its risks and vaccination risks being lower than health risks of COVID-19 infection, and self-reported trust in COVID-19 information. Our results lend strong support to the claim that the provision of targeted, tailored information on COVID-19 vaccine and infection increases parental intention to vaccinate children and reduces vaccine hesitancy.
Absence of long-term balancing selection on variation in EuMYB3, an R2R3-MYB gene responsible for the anther-color polymorphism in Erythronium umbilicatum
Authors: Lin Rong-Chien , Rausher Mark D. 
Published: March 2024

AbstractBalancing selection has been shown to be common in plants for several different types of traits, such as self-incompatibility and heterostyly. Generally, for these traits balancing selection is generated by interactions among individuals or between individuals and other species (e.g., pathogens or pollinators). However, there are phenotypic polymorphisms in plants that do not obviously involve types of interactions that generate balancing selection. Little is known about the extent to which balancing selection also acts to preserve these polymorphisms. Here we ask whether balancing selection preserves an anther-color polymorphism in Erythronium umbilicatum (Liliaceae). We identified a major gene underlying this polymorphism. We then attempted to detect signatures of balancing selection on that gene by developing a new coalescence test for balancing selection. We found that variation in anther color is in large part caused by variation in a paralog of EuMYB3, an anthocyanin-regulating R2R3-MYB transcription factor. However, we found little evidence for balancing selection having acted historically on EuMYB3. Our results thus suggest that plant polymorphisms, especially those not involved in interactions that are likely to generate negative frequency-dependent selection, may reflect a transient state in which one morph will eventually be fixed by either genetic drift or directional selection. Our results also suggest that regulation of the anthocyanin pathway is more evolutionarily labile than is generally believed.
Roboter-assistierte Hebung der M. latissimus dorsi – Lappenplastik:
Ein Fallbericht
Authors: Ehrl Denis , Nuernberger Tim , Stief Christian , Karcz Konrad , Giunta Riccardo E. 
Published: March 2024

ZusammenfassungNachdem die Robotik in verschiedenen Bereichen der Chirurgie und in der Urologie
fest etabliert ist, gewinnt sie rasant auch Relevanz in der Plastischen
Chirurgie. Der in diesem Manuskript dargestellte Fall beschreibt die erste
veröffentlichte robotisch-assistierten Hebungen einer M. latissimus dorsi
Lappenplastik im deutschsprachigen Raum. Dadurch soll das Wissen um die Robotik
in der Plastischen Chirurgie insgesamt geschärft und der Einzug der
robotisch-assistierten Plastische Chirurgie im deutschsprachigen Raum
unterstützt werden.
Altered Cervical Spine Position Results in Decreased Eccentric
Shoulder Rotation Strength
Authors: Giordano Kevin , Wasserberger Kyle , Oliver Gretchen D. 
Published: March 2024

AbstractOverhead athletes require strenuous shoulder activity in nonneutral cervical
spine positions to eccentrically decelerate the throwing/striking arm following
ball release/contact. We therefore aimed to compare eccentric shoulder rotation
strength through a 90° arc between neutral and rotated positions. Fifty-two
participants (19 M, 34 F 170±10 cm; 73±18 kg, 21.9±2.9 years) without shoulder
or cervical spine pathology participated. Isokinetic eccentric shoulder rotation
strength was measured through a 90° arc with the shoulder elevated 90° in
frontal plane (frontal plane), and 45° anterior to the frontal plane (scapular
plane) in neutral and rotated cervical spine positions. Cervical spine position
was obtained by instructing participants to maximally rotate their respective
side. Frontal plane eccentric external rotated strength differed between neutral
and contralaterally positions in the first 10° of the motion, near forearm
vertical (p+=+0.029). Internal rotation strength differed between neutral and
contralaterally rotated positions from 55–60° external rotation (p+=+0.004).
Scapular plane eccentric external rotation differed between cervical positions
between 21–67° shoulder external rotation (p<0.001). Scapular plane internal
rotation strength differed between cervical positions between 22–60° shoulder
external rotation (p<0.001). In populations requiring strenuous use of their
shoulders in altered cervical spine positions, sports medicine clinicians should
consider including strength testing that reflects the functional positions of
their patients during an orthopedic examination.
Subdural Hematoma due to Dural Metastasis: A Systematic Review on Frequency, Clinical Characteristics, and Neurosurgical Management
Authors: Pahwa Bhavya , Tayal Anish , Chandra Atulya , Das Joe M. 
Published: March 2024

Abstract
Background Subdural hematoma (SDH) occasionally accompanies dural metastasis and is associated with high recurrence rate, significantly impacting patient morbidity and mortality. This systematic review aims to evaluate the characteristics, management options, and outcomes of patients with SDH associated with dural metastasis.
Methods A comprehensive search of the PubMed and Cochrane databases was conducted for English-language studies published from inception to March 20, 2023, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The authors reviewed cases of histopathologically confirmed SDH with non-central nervous system (non-CNS) tumor metastasis, focusing on therapeutic management of SDH. Statistical analysis was performed using SPSS software, with a significance level set at 0.05.
Results This review included 32 studies comprising 37 patients with 43 SDH cases associated with dural metastasis. Chronic SDH was the most frequently observed presentation (n = 28, 65.12%). The systemic malignancies most commonly associated with SDH due to dural metastasis were prostate carcinoma (n = 9, 24.32%) and gastric carcinoma (n = 5, 13.51%). A statistically significant association was found between metastatic melanoma and subacute SDH (p = 0.010). The majority of patients were treated with burr holes (n = 15, 40.54%) or craniotomies (n = 14, 37.84%), with no statistically significant difference in mortality rates between the two techniques (p = 0.390). Adjuvant therapy was administered to a limited number of patients (n = 5, 13.51%), including chemotherapy (n = 2, 5.41%), whole brain radiotherapy (n = 1, 2.70%), a combination of chemotherapy and whole brain radiotherapy (n = 1, 2.70%), and transcatheter arterial chemoembolization (n = 1, 2.70%). The overall recurrence rate was 45.95% (n = 17), with burr holes being the most common management approach (n = 4, 10.81%). Within a median of 8 days, 67.57% (n = 25) of patients succumbed, primarily due to rebleeding (n = 3, 8.11%), disseminated intravascular coagulation (n = 3, 8.11%), and pneumonia (n = 3, 8.11%).
Conclusion This review highlights the need for improving existing neurosurgical options and exploring novel treatment methods. It also emphasizes the importance of dural biopsy in patients with suspected metastasis to rule out a neoplastic etiology.
Are there limits to globalising the medieval?
Authors: De Souza Rebecca 
Published: March 2024

AbstractThe aim of this article is threefold: firstly, it seeks to critique, from the perspective of Iberian and Latin American studies, the Eurocentrism inherent in the research programme known as the ‘Global Middle Ages’ that has emerged in the last two decades in Humanities faculties primarily in the USA and Europe. Secondly, it argues that the identification of global neomedievalism is particularly indicative of the Eurocentric limits of the global medieval paradigm, which is illustrated with several examples from Hispanophone contexts. Lastly, it proposes some alternative theoretical frames through which to analyse the histories of diverse geographies, which seek to account for multiple global temporalities in different linguistic traditions without reinforcing the medieval/modern construction that is in turn rooted in systemic forms of racism and antiblackness.
Simulation study on arc motion process of 38 A low-voltage AC contactor under AC-4 conditions
Authors: Ma Chen , Ge Shiwei , Zhang Hongwei , Ji Xinhua , Wang Zhenkun , Guo Ze 
Published: March 2024

In the process of breaking an AC contactor, the ablation of the contact by the arc current is an important factor affecting its electrical life, so the evolution of arc shape in the arc extinguishing chamber has an important influence on its breaking performance. To explore the influence of arc motion characteristics on its breaking characteristics, based on the theory of magnetohydrodynamics and considering the contact motion process, a three-dimensional air arc simulation model is established for the arc extinguishing chamber of an AC contactor with a fixed current of 38 A and the arc motion characteristics of the arc during breaking are analyzed. To verify the accuracy of the simulation model, a test platform was built. Under the same breaking conditions, the arc shape, arc voltage, and arc current were measured, and the experimental results were consistent with the simulation results. On this basis, an optimization scheme of the arc extinguishing component is proposed and its influence on the arc motion process is analyzed.
Numerical investigation on oil–water flow characteristics and construction optimization for novel wellbore lubrication fitting
Authors: Jing Jiaqiang , Huang Wanni , Karimov Rinat , Sun Jie , Li Yibo 
Published: March 2024

Water-lubricated oil–water flow is an effective low-energy consumption method for pipeline transportation. This study proposes a novel wellbore lubrication fitting (WLF) for developing a core-swirling flow to reduce flow resistance and enhance lubrication efficiency. The pressure drop across the lubricating fitting, the maximum oil volume fraction at the overflow outlet and the drag reduction percentage of core-swirling flow were taken as the indicators, and the fluid calculation software Ansys Fluent was applied to optimize the structural parameters of the WLF with orthogonal and single-factor methods. The experimental study was carried out with mineral oil and tap water. The results indicate that the swirl generator can develop a stable and low-viscosity liquid annulus to isolate the oil from the pipe wall and reduce the flow resistance of viscous oil. The optimized WLF demonstrates the clear core-swirling flow with input velocity between 0.48 and 0.62 m/s. The experimental pressure drops deviate from the simulated data within ±25%. The drag reduction percentage of the core-swirling flow is above 90% with the input velocity above 0.51 m/s. The results of this study have important engineering value for efficient application of WLFs.
Viscosity and surface tension of the Zr56.5Ti13.3Ni13.6Cu9.6S7 bulk metallic glass-forming liquid
Authors: Ruschel Lucas Matthias , Kuball Alexander , Adam Bastian , Frey Maximilian , Busch Ralf 
Published: March 2024

The viscosity of the Zr56.5Ti13.3Ni13.6Cu9.6S7 bulk glass forming alloy was measured in equilibrium liquid at low and high temperatures. Low temperature measurements were conducted in the vicinity of the glass transition using a thermomechanical analyzer, covering a viscosity range between 109 and 1014 Pa s. The high-temperature experiments were carried out by electromagnetic levitation of a spherical droplet in microgravity during a parabolic flight campaign (TEMPUS), ranging in viscosity from 50 to 800 mPa s. The viscosities were individually modeled using the Vogel–Fulcher–Tammann equation to obtain the fragility parameter D*, which displays a strong liquid behavior of 25.8 and 19.6 for the low and high temperature region, respectively. The Mauro–Yue–Ellison–Gupta–Allan viscosity model was additionally applied, revealing an even more accurate description across the whole temperature range. Next to viscosity, TEMPUS measurements allow the determination of surface tension. With a value of 0.9 N m−1, it is significantly lower than that of other Zr-based metallic glasses without the element sulfur.
Flexible SERS substrate with tunable gap based on laser-induced reduction
Authors: Li Wanyi , Xu Hankun , Li Hongxu , Li Yang , Liu Jiale , Liang Guangrui , Chen Kemiao , Sun Huojiao 
Published: March 2024

In order to break the limitation that the gap is fixed once it was synthesized for traditional flexible surface-enhanced Raman scattering substrate, in this work, a laser-induced reduction method was used to fabricate ordered silver nanodot arrays on flexible substrates. By using rhodamine 6G as a probe molecule, Raman characterization is carried out on the hydrogel film/silver substrate at expanded and shrunken states. The substrate shows great reproducibility, and the average relative standard deviation of the probe is 8.7%. In addition, when the hydrogel film was shrunk by 75%, the intensity at 1650 cm−1 will be enhanced by about 36 times, and the detection concentration of the R6G molecule can reach 10−7 mol/l.
The transmission of Spanish as a heritage language in Australia
Authors: Hernández Gallego Milena Adriana , Doquin de Saint-Preux Anna 
Published: March 2024

Abstract
Although the terms ‘heritage speakers’ and ‘heritage languages’ are relatively new, the phenomena themselves date
back to the beginning of migration. In many situations heritage languages do not survive these changes, but in others they are
maintained successfully. This research explores the individual factors that promote the maintenance of Spanish as a heritage
language in Australia. To achieve this, we preselected the most relevant individual factors found in the literature, that were
then included in a questionnaire that reflected the research questions of this study and was distributed online. Participants in
this study were 27 adult Australian heritage speakers who were either born in Australia or have lived in Australia since
childhood. The results suggest / indicate that the preselected individual factors: the feeling of identification with the
heritage language, the motivation to speak the heritage language, and the prestige that is given to
Spanish by both the parents and the heritage speakers correlate statistically with the maintenance of Spanish as a
heritage language.
Implementing feedback literacy practices through self-sssessment and peer feedback
Authors: Soltani Behnam , Zhang Lawrence Jun 
Published: March 2024

Abstract
This paper draws on language socialization theory and uses narrative frames and interview to investigate an
international student’s socialization into feedback literacy practices in an EAP classroom. The analysis of findings shows that
using a narrative frame methodology is an effective assessment tool that helps students assess and reflect on their own learning
because they help students develop an ability to: (1) learn to judge their own and their peers’ performance and develop evaluative
judgment, (2) socialize themselves and be socialized into literacy norms of their academic context, and (3) follow up their own
learning trajectories and learning to learn by reflecting on their current and possible future performance in familiar and
unfamiliar work and life contexts. The study concludes that socialization into feedback practices becomes significant when the
linguistic, literate, and cultural practices of students are recognized as resources and assets in their classroom community.