bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Factors of Early Neurologic Deterioration in Isolated Pontine Infarction
Authors: Gao Shan , Wu Wenbo , Yang Haocheng , Gou Yulan 
Published: February 2025

Background and Objectives:
Neurologic deterioration frequently occurs during the acute phase of isolated pontine infarction (IPI). However, the factors that predict early neurologic deterioration (END) are not well understood. The purpose of this study is to identify and analyze the predictors of END in individuals with IPI.

Methods:
One hundred and fifty-three patients diagnosed with acute IPI were included in this retrospective study, including 41 individuals in the END group and 112 in the non-END group. Demographic characteristics, clinical data, and imaging features were collected and compared. Logistic regression analysis was used to identify independent predictors of END in patients with IPI, and a receiver operating characteristic (ROC) curve was constructed to assess model performance.

Results:
Univariate analysis demonstrated significant differences between the two groups regarding diabetes mellitus, National Institute of Health Stroke Scale (NIHSS) score at admission, etiological classification, and infarct area, with P values less than 0.05. Multivariate binary logistic regression analysis revealed that the NIHSS score at admission and the infarct size were independent predictors of END. The combined ROC analysis of the NIHSS score at admission and the infarct area for predicting END showed a sensitivity of 85.4%, specificity of 83.0%, and an area under the curve of 0.887.

Conclusions:
Basilar artery branch disease is the primary cause of END observed in IPI. Both the NIHSS score at admission and the size of the infarct serve as significant predictors for END in IPI, and the combination of two factors provides value in predicting END and outcomes of IPI patients. Early prediction of END also can guide treatment strategies, aimed at improving patient prognosis.
An Observational Study on Clinicopathological Characteristics and Correlation with Pathological Response in Patients Post-neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Authors: Rumani Imaan , Chakrabarti Jayanta , Mandal Sandip Swarup , Gupta Souradip , Kazi Bilal , Majumder Koustav , Chakrabarti Srabani , Nanda Durga Prasad , Paul Ratnadeep 
Published: February 2025

Abstract

Background:
Locally advanced breast cancer, the most advanced stage of nonmetastatic breast cancer, has a substantial risk of recurrence, metastasis, and death, with a 5-year overall survival rate of approximately 57%.

Aims and Objective:
The aim of the study was to correlate and compare the clinical, radiological, and the pathological parameters in assessing the tumor response to neoadjuvant chemotherapy (NACT) and to assess rates of complete clinical and pathological response in patients of breast carcinoma being treated with NACT.

Materials and Methods:
This study was a prospective, nonrandomized, observational study. This study was conducted at Chittaranjan National Cancer Institute, Kolkata from January 2021 to January 2023 in the Department of Surgical Oncology. A total of 131 patients were included in this study.

Results:
It was found that the majority of patients (51.1%) showed a complete pathological response in the lymph nodes with the maximum number of patients belonging to the basal-like subgroup (20); it was statistically significant (P = 0.001). Higher number of patients had (57.1%) moderate residual disease (residual cancer burden [RCB1]) on final histopathology in luminal A type compared to (54.3%) luminal B type, (47.6%) basal like, and human epidermal growth receptor-2 enriched (31.0%), so correlation of molecular types and RCB was statistically significant (P < 0.001).

Conclusion:
From our study, we conclude that histopathological examination is the gold standard for assessing chemotherapeutic tumor response in breast carcinoma. Patients with molecular subtype HER2 neu and triple negative were good responders to chemotherapy. There was a reduction in the tumor size and an increase in clinically node-negative status following chemotherapy, indicating downstaging of the tumor in the majority of the patients after NACT. Neoadjuvant therapy can potentially make inoperable tumors operable. Patients who achieve a complete clinical response may not have a complete pathological response. The prognosis of the patient cannot be predicted depending on clinical response.
Study of Ki-67, β-catenin, and E-cadherin in Colorectal Carcinoma: A Clinicopathological Study
Authors: Poornima Komati , Mazumder Cheryl , Pal Ranita , Mandal Syamsundar , Mustafi Saunak Mitra , Nasare Vilas D. 
Published: February 2025

Abstract

Background:
Colorectal cancer (CRC) is a common cancer worldwide with a low reported incidence in India. It is the fourth most common cause of death due to cancer. Therefore, better prognostic or predictive markers are needed to improve survival of the disease. The present study may help to state potential role of Ki 67, β-Catenin and E cadherin in association with various clinicopathological parameters to assessing the tumor prognosis of colorectal cancer.

Aim and Objective:
The objective is to examine the clinicopathological parameters of colorectal tumors and their correlation with Ki-67, E-cadherin, and β-catenin expressions.

Material and Methods:
This is a prospective study that included surgical (colectomy) tissues and colonoscopy biopsies from 64 patients who were recruited at Chittaranjan National Cancer Institute (CNCI), Kolkata from September 2016 to February 2018. Clinico-histopathology and Immunohistochemistry for Ki-67, E-cadherin, and β-catenin were performed on the samples.

Results:
This study showed an increasing incidence of colorectal carcinoma (CRC) in young younger individuals ≤40 years. Many patients presented with advanced stage and higher grades of the tumor with the rectum (42.2%) being the most common site of the tumor. The corrected Chi-square (c2) test showed a significant association between Histopathological evaluation (HPE) and tumor grades with Ki-67, E-cadherin, and β-catenin expressions (p<0.0001).

Conclusion:
Ki67 expression in CRCs is associated with good clinical outcomes. All three markers showed an independent expression in colorectal cancer, they are strongly associated with tumor grade individually. It helps in predicting the tumor prognosis.
Clinicopathological Analysis for the Necessity of Level 2b Lymph Node Dissection in Elective Neck Dissection for Oral Squamous Cell Carcinomas – A Retrospective Institutional Study
Authors: Dey Samyadipta , Chakraborty Kaushambi , Kar Pinakpani , Kumari Dipti 
Published: February 2025

Abstract

Background:
Oral squamous cell carcinoma (OSCC) represents 32%–40% of all head-and-neck cancers (HNC).[1] Most of these CA metastasize locally to the cervical lymph nodes. Level 2 lies anterior to the posterior border of the sternocleidomastoid (SCM) muscle and posterior to a vertical line drawn from the posterior edge of the submandibular gland. It is further subdivided into 2a and 2b by the spinal accessory nerve (SAN). Some surgeons strongly recommend dissection of level 2b for all patients, while some do not advocate it if it is clinically negative. An injury or sacrifice of the SAN results in denervation and atrophy of the trapezius muscle leading to a condition called “Shoulder Syndrome” and subsequently affecting the quality of life of the patient. Against this background, it remains a matter of debate whether level 2b dissection should be done.

Aims and Objectives:
We performed a postoperative histopathological analysis of tumour size, depth of invasion (DOI), and nodal metastasis and attempted to know whether level 2b dissection can be avoided in early as well as advanced oral squamous cell cancers (OSCC) or not.

Materials and Methods:
A retrospective analysis of 50 patients with OSCC patient, after curative surgery with elective neck dissection, was conducted to see the correlation and incidence of level IIB positivity with demographic factors, tumor subsite, pathological staging, DOI, and corresponding level 2a status.

Results:
In our study, only 36% are positive for level 2b lymph node. Therefore, retrospectively, we have concluded that only in 36% of cases, level 2b neck dissection was necessary. In the rest 64% of the cases, level 2b lymph node dissection could have been avoided. For tumors, a pathological staging of pT4aN2b and pT4N3b had the highest level 2b positivity, while Level 2b positivity was nil in early-stage oral squamous cell carcinomas with N0 neck. Tumors having DOI of 14 and 15 mm showed the highest level of 2b node positivity with a mean of 17.78 mm and an SD of 11.28 mm. As per oral subsite, buccal mucosa, lower alveolus, and tongue showed the highest level 2b positivity, while carcinoma of the lip and CA retromolar trigone showed the lowest level 2b positivity.

Conclusion:
As per our results, many patients could have been spared from inadvertent SAN injury and shoulder dysfunction during neck dissection. Pertaining to our results, it can be safely concluded that level 2b neck dissection may be avoided in early T1 and T2 tumors with N0 neck, although further studies are required on preoperative clinico-radiological correlation with postoperative histopathological analysis.
Assessment of Immunohistochemical Expression of Vitamin D Receptor in Surgically Excised Cutaneous Melanoma from Egyptian Patients
Authors: Bebars Shaimaa M.M. , Hasan Abdulkarim , Ghanam Walaa , Al-Ghamdi Hasan S. , Alghamdi Mohammad A. , Samman Abdulhadi , Noorwali Hussain , Abdelwahed Mohammed S. , Mohammed Yasien , Salem Mahmoud , Maawad Ahmed Nabil , Mostafa Amr M. , Elsagheer Khaled A. , El Bostany Mona Zakaria , Shokery Sara Ehab M. , Mandour Essam 
Published: February 2025

Abstract

Background:
Vitamin D, acting via the vitamin D receptor (VDR), has antitumor effects through inhibition of proliferation and angiogenesis. Some previous studies showed an inverse correlation between VDR expression and the progression of cutaneous melanoma; however, other studies did not find this correlation, suggesting a probable ethnic/geographic effect. We aimed to evaluate the expression pattern of VDR in cases of cutaneous melanoma in a Middle Eastern country, Egypt.

Materials and Methods:
A total of 42 paraffin blocks and slides from 42 patients were retrieved from the pathology archives of our institution and immunohistochemically stained against VDR. The density and pattern of VDR immunostaining in positively stained cases were analyzed and compared with various demographic, clinical, and histological parameters of Egyptian patients who underwent surgical excision for cutaneous melanoma between 2017 and 2022.

Results:
A total of 37 cases (88.1%) expressed VDR, showing no significant correlation with the tumor site, size, metastasis, or invasion. However, a statistically significant difference was observed between nuclear and cytoplasmic VDR expression. Nuclear expression was associated with unfavorable tumor characteristics, including increased Breslow thickness, Clark level, and vascular invasion.

Conclusion:
VDR expression can serve as a prognostic marker in the histopathological evaluation of cutaneous melanoma; however, the utility of nuclear versus cytoplasmic expression of VDR should be more studied in the future research incorporating genetic analysis. Our findings, in contrast to several previous studies but in agreement with a few, suggest an association between nuclear staining and tumor progression.
Program Kecakapan Wirausaha Untuk Keselamatan Dan Kesehatan Kerja (K3) Bidang Keahlian Tata Rias Kecantikan Pada Warga Karanganyar Tahun 2024
Authors: Prastowo Ichwan , Sudarmaji Sudarmaji , Wibiyanto Agung 
Published: February 2025

Program kecakapan wirausaha untuk Keselamatan dan Kesehatan Kerja (K3) Bidang Keahlian Tata Rias Kecantikan ini bertujuan memberikan pengetahuan tentang Keselamatan dan Kesehatan Kerja, memberikan ketrampilan penggunaan alat dan bahan yang aman berkaitan dengan Keselamatan dan Kesehatan Kerja, memberikan cara pencegahan terjadinya kecelakaan kerja dan penyakit akibat kerja bagi para calon wirausahawan pada bidang keahlian tata rias kecantikan. Metode yang digunakan untuk mencapai tujuan tersebut adalah dengan memberikan pelatihan dengan cara memberikan teori terlebih dahulu secara umum kemudian khusus tentang pentingnya peranan Keselamatan dan Kesehatan Kerja, memberikan praktek memilih bahan kecantikan yang aman dan penggunaan Alat Pelindung Diri (APD) yang baik, Cara pencegahan terjadinya kecelakaan kerja dan Penyakit Akibat Kerja (PAK). Hasil dari program ini adalah para calon wirausahawan mendapatkan pengetahuan tentang Keselamatan dan Kesehatan Kerja sehingga dapat menertapkan di tempat kerja dengan baik, peserta pelatihan mendapatkan ketrampilan tentang pemilihan bahan yang baik dengan memperhatikan brand, lebel dan kedaluwarsa (expired) serta trampil menggunakan Alat Pelindung Diri (APD), para peserta dapat mencegah terjadinya kecelakaan kerja dan Penyakit Akibat Kerja (PAK).
Using time series methods to analyse the COVID-19 pandemic's impact on food and beverage sales trends in South Africa.
Authors: Makoni Tendai , Chikobvu Delson 
Published: February 2025

Research Aims: Food is essential to human survival, but the COVID-19 pandemic posed significant risks to the food value chain in many countries, including South Africa (SA). The pandemic disrupted the food supply chain, creating an unprecedented challenge for the SA food and beverage industry. This study aims to use time series methods to investigate and understand how the COVID-19 pandemic has affected food and beverage sales trends in SA.
Design/methodology/approach: The monthly food and beverage sales data is analysed using the Box-Jenkins methodology.
Research Findings: A SARIMA(0,1,1)(1,1,1)12 model is confirmed as the best model based on the Akaike Information Criterion. The Root Mean Square Error and Mean Absolute Error metrics support the model's forecasting performance. The findings reveal that the COVID-19 pandemic harmed the food and beverage industry, with sales not yet fully recovered to pre-pandemic levels. This highlights the severity of the pandemic's effects on South Africa’s food and beverage industry. However, there is a positive sign of recovery, with future food and beverage sales expected to rise. This recovery is driven by the adoption of digital technologies by many food and beverage companies, enabling them to adjust to the evolving circumstances. Businesses adopting digital solutions like online ordering, delivery platforms, and mobile marketing witness a more robust recovery. Such investments aid food and beverage companies to broaden their clientele, improve operations, and adapt to changing consumer demands post-pandemic. Expanding online ordering, subscription-based delivery, contactless payments, and catering to dietary needs attracts new customers and enhances brand reputation.
Theoretical Contribution/Originality:

Keywords: South Africa; Food and beverage sales; forecasting; COVID-19 pandemic.
Implementasi Jual Beli Emas Dengan Sistem Tukar Tambah Di Toko Emas H. ST. Martua Hsb Pasar Sibuhuan Menurut Perspektif Ekonomi Islam
Authors: Ida Ayu Lestariyana Hasibuan  , H.Amhar Maulana  , Nur Jannah Nasution  
Published: February 2025

This thesis aims: (1) Implementation of Gold Buying and Selling with an Exchange System at the H Gold Shop. (2) To find out the implementation of buying and selling gold using an exchange system at the H. ST Gold Shop. Martua Hsb Sibuhuan Market according to an Islamic economic perspektive. This research is field research (filed research ) With a qualitative research type . The research subjects were customers, owners and employees of the H.ST Gold Shop. Martua Hsb Sibuhuan Market. Data collection techniques through interviews, observation and documentation. Data analysis techniques are data reduction, data presentation and drawing conclusions. The results of the research show that: (1) ST. Martua Hsb Sibuhuan Market in its implementation, consumers came bring old jewelry that has been worn previously with a purpose want to exchange the old jewelry for new jewelry by bringing proof of jewelry certificate after the gold has been weighed and appraised the price and additional charges per gram, it also depends on the condition of the old gold jewelry. If it is not damaged then it will be wor additional per gram Rp. 20,000 whereas if it is damaged then additional/cut will differ according to the condition of the gold, additional This will be used for cleaning costs. As for the system The payment is agreed upon at the time of the contract before leaving the assembly. (2) Implementation of Gold Buying and Selling with an Exchange System at the H. ST Gold Shop. Martua Hsb Sibuhuan Market according to an Islamic ecomic perspektive, if it is linked to the concept of buying and selling using an exchange system, the terms and conditions of buying and selling have been fulfilled. The process of determining and adding prices is in accordance with the concept of justice in Islamic. So in practice it is in line with the concept of buying and selling with an exchange system where in the transaction the buyer and seller negotiate to get a price that matches the desired price by considering the type and quality of the goods. All terms and conditions of sale and purchase can be realized so that the contract is valid and there is no damage to the contract because both parties are willing and pleased to carry out the transaction
Enhancement of state response capability and famine mitigation: a comparative analysis of two drought events in northern China during the Ming dynasty
Authors: Tian Fangyu , Su Yun , Chen Xudong , Tao Le 
Published: February 2025

Abstract. Studying social impacts of and responses to historical extreme climate events can offer valuable insights into coping with major disaster events and adapting to climate change better. This paper developed a model of the processes and responses to extreme drought-induced famines in ancient China. Based on this, the study explored the differences in famine causation and response effectiveness between the Chenghua drought (1483–1486 CE) and Wanli drought (1585–1588 CE). The findings are as follows: (1) by the time of the Wanli drought, the increase in land reclamation had enhanced societal defence, preventing many drought-affected counties from experiencing famine. Even in cases where famines did occur, their severity was lower than during the Chenghua drought. (2) State emergency measures, including exemption and relief, proved effective in mitigating famines. The stronger finance and economy during the Wanli drought enabled more robust relief efforts, resulting in lower famine severity. (3) Famine response capabilities varied regionally. Shandong, Beijing, Tianjin, and Hebei demonstrated strong defensive capabilities and effective state emergency responses, while Shanxi had weaker defensive abilities, making it more vulnerable to famine. The defensive capabilities in Henan, Shaanxi, Gansu, and Ningxia showed significant improvement.
Konsep Makanan Halal, Thayyib, dan Haram dalam Al-Qur’an Menurut Tafsir Asy-Sya’rawi
Authors: Syaifullah Imam Azis , Sulthoni Akhmad , Saputra Akhmadiyah 
Published: February 2025

Allah menegasakan di dalam Al quran agar manusia mengkonsumsi makanan yang halal lagi baik dan juga bergizi (halalan thayyiban), sedangkan dalam hal haram maka, manusia diwajikan sejauh mungkin untuk meninggalkannya, Penelitian ini bertujuan untuk mengkaji lebih dalam konsep makanan halal dan thayyib serta menguraikan makna dan unsur yang terkandung dalam konsep halal dan thayyib menurut tafsir Asy-Sya’rawi. Penelitian ini merupakan penelitian kepustakaan (library research) dengan metode penafsiran tematik. Hasil penelitian ini menurut tafsir Asy-Sya'rawi pada ayat Al-Baqarah ayat 168 menyatakan bahwa pentingnya menjaga kehalalan dan kebaikan makanan yang dikonsumsi. Pada ayat An-Nahl ayat 114 memberikan pemahaman yang komprehensif tentang konsep halal dalam Islam. Beliau menjelaskan bahwa halal bukan hanya terkait dengan makanan, tetapi juga dengan segala aspek kehidupan. Beliau juga menekankan pentingnya menjaga kesehatan jasmani dan rohani dengan memakan makanan halal dan thayyib, serta mensyukuri nikmat Allah SWT dengan cara yang benar. Asy-Sya’rawi dalam tafsirnya menjelaskan bahwa makanan haram terbagi menjadi dua kategori utama yaitu haram li dzatihi (haram karena zatnya) dan haram li ghairhi (haram karena sebab lain)
Rasionalisme Sebagai Cabang Filsafat dan Pengaruhnya pada Tafsir Al-Manar
Authors: Zulfiya Ida 
Published: February 2025

Rasionalisme merupakan bagian dari masyarakat modern, di mana sistem berpikir ini memang dicetuskan di dunia Barat oleh René Descartes yang ditasbihkan sebagai ‘bapak filsafat modern’. Di dunia Islam, rasionalisme sudah berkembang sendiri tanpa dipengaruhi oleh filsafat Yunani yang dimulai dari mazhab nahwu (kebahasaan). Tafsîr al-Manâr merupakan salah satu tafsir yang ditulis oleh mufasir abad modern, yaitu Muḥammad ‘Abduh dan Rasyid Riḍâ, di mana keduanya disebut sebagai tokoh yang melandaskan setiap argumentasinya melalui pemahaman yang rasional. Artikel ini akan membahas secara kritis bagaimana rasionalisme Muhammad ‘Abduh dan Rasyid Riḍā mempengaruhi setiap uraian pemaknaan ayat-ayat al-Qur’an di dalam Tafsîr al-Manâr.
ACIDENTES COM ANIMAIS PEÇONHENTOS E A IMPORTÂNCIA DAS MEDIDAS PROTETIVAS: UM ESTUDO NO MUNICÍPIO DE TRÊS RIOS DE 2014 A 2023
Authors: Amorim Ana Paula da Conceição Fernandes de , Santos Moana Ferreira dos , Amorim Juliana Ferreira de 
Published: February 2025

Os acidentes com animais peçonhentos são um problemas de saúde pública global, principalmente em países pobres tropicais e subtropicais. Devido a elevada morbidade e mortalidade a Organização Mundial de Saúde (OMS) incluiu esse agravo na lista de doenças tropicais negligenciadas (DTN). Este é um estudo transversal realizado com dados secundários no banco de dados do Ministério da Saúde/SVS - Sistema de Informação de Agravos de Notificação - SinanNet (DATASUS-SINAN), sobre acidentes com animais peçonhentos no município de Três Rios, Estado do Rio de Janeiro, no período de 2014 a 2023. Nesse período foram notificados 943 acidentes sendo a maior incidência provocada por escorpião de espécie desconhecida (62,44%), seguida de serpentes (19,83%). Das serpentes de importância medica na região a que mais provocou acidentes foram animais do grupo Bothrops, conhecidas como jararacas (76,33%). Em relação as aranhas a Phoneutria, também conhecida como armadeira foi responsável pelo maior número de acidentes (46%). Os homens foram os mais afetados e a idade de maior exposição foi de 20 a 59 anos em ambos os sexos. Para diminuir o risco de acidentes com esses animais existem várias ações preventivas individuais e coletivas. Muitas vezes é necessário e prudente solicitar ajuda do poder público. (108) = 198.