bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Effects of High-Fiber and Low-Fiber Diets on Antitumor Immunity and Colon Tumor Progression in a Murine Model
Authors: Goggin Kevin E. , Seo SeonYeong Jamie , Wu Benjamin G. , Ivelja Sinisa , Kugler Matthias C. , Chang Miao , Darawshy Fares , Li Yonghua , Chung Cecilia J. , Kyeremateng Yaa , Tsay Jun-Chieh J. , Singh Shivani , Sterman Daniel H. , Segal Leopoldo N. , Egilmez Nejat K. , Li Qingsheng 
Published: February 2025

Abstract
The role of dietary fiber in colon cancer prevention remains controversial. We investigated its impact on antitumor immunity and the gut microbiota in APCmin/+ mice infected with enterotoxigenic Bacteroides fragilis. Mice were fed high-fiber, low-fiber, or chow diets, and the tumor burden, survival, cytokines, microbiota, and metabolites were analyzed. Contrary to the belief that high fiber inhibits tumor progression, it had no significant impact compared with chow diet. However, the low-fiber diet significantly reduced the tumor burden and improved survival. Mechanistically, high fiber increased proinflammatory cytokines and CD4+Foxp3+RORγt+IL-17A+ regulatory T cells, whereas low fiber enhanced anti-inflammatory cytokines and cytotoxic T cells. High fiber enriched microbial taxa associated with IL-17A+RORγt+ regulatory T cells and altered metabolites, including reduced tryptophan and increased short-chain fatty acids and bile acids. Low fiber produced opposite effects. These findings suggest that dietary fiber’s effects on colon cancer depends on microbial infection and immune status, emphasizing the need for personalized dietary interventions in colon cancer management.
Prevention Relevance: Dietary fiber’s impact on colon cancer progression highlights the need for personalized dietary approaches, considering microbial infection and immune status.
Individual connectivity-based parcellations reflect functional properties of human auditory cortex
Authors: Hakonen Maria , Dahmani Louisa , Lankinen Kaisu , Ren Jianxun , Barbaro Julianna , Blazejewska Anna , Cui Weigang , Kotlarz Parker , Li Meiling , Polimeni Jonathan R. , Turpin Tori , Uluç Işıl , Wang Danhong , Liu Hesheng , Ahveninen Jyrki 
Published: February 2025

Abstract
Neuroimaging studies of the functional organization of human auditory cortex have focused on group-level analyses to identify tendencies that represent the typical brain. Here, we mapped auditory areas of the human superior temporal cortex (STC) in 30 participants (15 women) by combining functional network analysis and 1-mm isotropic resolution 7T functional magnetic resonance imaging (fMRI). Two resting-state fMRI sessions, and one or two auditory and audiovisual speech localizer sessions, were collected on 3–4 separate days. We generated a set of functional network-based parcellations from these data. Solutions with 4, 6, and 11 networks were selected for closer examination based on local maxima of the Dice coefficients and Silhouette values. The resulting parcellation of auditory cortices showed intraindividual reproducibility of 69–78% between resting-state sessions and 62–73% between resting-state and task sessions, indicating moderate reproducibility. The interindividual variability was significantly larger than intraindividual variability (Dice coefficient: 57%–68%, p &lt; 0.001), indicating that the parcellations also captured meaningful interindividual variability. The individual-specific parcellations yielded the highest alignment with task response topographies, suggesting that individual variability in parcellations reflects individual variability in auditory function. Connectional homogeneity within networks was also highest for the individual-specific parcellations. Furthermore, the similarity in the functional parcellations was not explainable by the similarity of macroanatomical properties of the auditory cortex. Together, our results show that auditory areas in STC can be segmented into functional subareas based on functional connectivity. Our findings also suggest that individual-level parcellations capture meaningful idiosyncrasies in auditory cortex organization.
Gnosis as Dissent?
Authors: Dudoignon Stéphane A. 
Published: February 2025

Abstract
Islam in the USSR was long described as resistant to Sovietization, but also as reluctant to dissidence which is much better documented in the European regions of the Soviet Union. Since the turn of the 21st century, however, the publication in Central Asia of previously unknown manuscripts has brought to light the production, through the short 20th century, of a Muslim gnostic poetry of classical form and content, by authors from a small number of mutually linked sacred lineages, transmitters of the Sufi tradition (ritualised Islamic gnosticism). Among the issues that this production raises is the existence of a Muslim ‘underground’ steeped in ascetic tradition, and this underground’s relationship to Soviet culture, which it opposed in a radical way, playing the roles of a focus of resistance to the ‘idolatries’ of the era and of the harbinger of an apocalypse in the present. The present study of two Persian-language Sufi poets, a master and his disciple, active in the Tajik SSR between the 1920s and the 1980s, questions the supposed absence of dissidence in predominantly rural Central Asian societies, which were latecomers to samizdat. It leads us, too, to question the notion of historical change, through a phenomenon of apparent continuity of literary forms and practices, against the peculiar backdrops of Soviet modernisation and post-Soviet nation-building.
Long-term chronic conditions in individuals with mental and behavioural disorders: A data linkage study
Authors: Lee Crystal Man Ying , Graham-Schmidt Kyran , Chai Kevin EK , Rock Daniel , Robinson Suzanne , Coleman Mathew , Betts Kim S , McEvoy Peter M 
Published: February 2025

Objective: This study aimed to investigate the physical health conditions among health service users in the first year since recorded mental disorder diagnosis in Western Australia. Methods: Community mental health, emergency department (ED) and inpatient records of individuals aged ⩾ 18 years with a recorded mental disorder diagnosis in state-funded health services were analysed. We identified long-term physical health conditions recorded within the first year of the first recorded mental disorder diagnosis. Prevalence of physical comorbidity across time was estimated using multinomial logistic regression. Mean number of health service contacts in the first year of the recorded mental disorder diagnosis was obtained using generalised linear model. Results: Altogether, 253,362 individuals were included. Within the first year of the first recorded mental disorder, the prevalence of at least one physical comorbidity ranged from 20.0% in 2006 to 14.5% in 2020. Cardiovascular disease was the most common comorbidity, but the most common combinations of comorbidities became more varied over time. The number of ED and inpatient contacts were higher in subgroups with a higher number of physical comorbidities (ED contacts: 2.4 [95% confidence intervals: 2.4, 2.4] for no comorbidities to 3.6 [3.4, 3.8] for ⩾ 3 comorbidities; inpatient contacts: 2.6 [2.6, 2.7] for no comorbidities to 4.5 [4.1, 4.9] for ⩾ 3 comorbidities). Conclusion: With a substantial proportion of individuals with mental disorders already having physical comorbidities on their first year of contact with state-funded health services, and the comorbidity combinations becoming more diverse, there is a need to implement more comprehensive joint mental and physical health services.
Comparative study between unilateral and bilateral extrapedicular approaches for osteoporotic vertebral compression fractures: A retrospective study
Authors: Zhao Xuequan , Han Xixi , Li Chenxu , Han Baoguo , Zhu Tianjiao , Shi Yuxue , Liu Qinglei , Zhang Yafeng 
Published: February 2025

Objective Percutaneous vertebroplasty (PVP) is a primary treatment for osteoporotic vertebral compression fractures (OVCF). Historically, surgeons preferred a bilateral approach for PVP; however, this approach may impose greater financial strain on patients. This retrospective study examines the efficacy of the unilateral approach compared to the bilateral approach. Methods A total of193 patients were categorized into Group A (unilaterally extrapedicular approach) and Group B (bilateral approach) based on the operative method. Efficacy was evaluated using perioperative indicators, follow-up results, and imaging evaluation results. Results Out of the 193 patients involved, 169 were eligible for analysis. All patients completed follow-up visits lasting 49–70 months. Compared to Group B, Group A exhibited significantly shorter operation time, puncture duration, amount of bone cement injected, and number of X-ray fluoroscopies ( P < 0.05). While initial pain reduction, as measured by the visual analog scale and Oswestry Disability Index scores, was lower in Group A, the difference between the groups narrowed by the final follow-up. At the final imaging follow-up, no statistically significant differences were observed between the two groups regarding the relative height of the injured vertebral bodies and local Cobb angle measurements. Conclusions This technique holds the potential for accelerated patient rehabilitation and reduced hospitalization expenses, presenting a promising treatment option for OVCF patients.
A Cadaveric Study of the Sagittal Patellar Insertion of the Medial Patellofemoral Ligament in Children: Implications for Reconstruction
Authors: Alayleh Amin , Hollyer Ian , Johnstone Thomas , Khoo Bryan , Obilo Chiamaka , McFarlane Kelly , Baird Wills , Chan Calvin , Tompkins Marc , Ellis Henry , Schmitz Matthew , Yen Yi-Meng , Ganley Theodore , Sherman Seth L. , Shea Kevin G. 
Published: February 2025

Background: Patellofemoral instability is a common problem, and medial patellofemoral ligament (MPFL) reconstruction is a standard treatment approach for recurrent instability. The accurate restoration of anatomy in MPFL reconstruction is essential. While coronal-plane anatomy of the MPFL patellar insertion has been previously reported, sagittal-plane anatomy has not been widely studied. Purpose: To evaluate the sagittal patellar insertion of the MPFL in pediatric specimens to guide future anatomic reconstruction. Study Design: Descriptive laboratory study. Methods: A total of 11 pediatric cadaveric knee specimens were dissected. The patella and sagittal MPFL insertion were evaluated. The maximal anterior-posterior patellar width, distance from the posterior patella to the posterior MPFL insertion, distance from the medial patellar articular cartilage edge to the MPFL insertion, maximal MPFL thickness, and distance from the anterior MPFL insertion to the anterior patella were measured. The proportion of patellar coverage by the sagittal MPFL insertion footprint was calculated. Results: The pediatric knee specimens had a mean age of 9.3 ± 1.4 years (range, 6-11 years). The mean maximal transverse patellar width was 19.0 ± 2.7 mm (range, 13.7-22.7 mm). The mean posterior patella–to–posterior MPFL distance was 10.5 ± 1.6 mm (range, 7.7-12.6 mm). The mean patellar articular cartilage edge–to–MPFL distance was 2.3 ± 0.6 mm (range, 1.5-3.5 mm). The mean maximal MPFL thickness was 4.0 ± 0.9 mm (range, 2.6-5.5 mm). The mean anterior MPFL–to–anterior patella distance was 4.4 ± 1.1 mm (range, 2.6-5.8 mm). The sagittal MPFL insertion footprint spanned a mean of 21.0% (range, 16.1%-29.7%) of the medial patella. Conclusion: This study, utilizing skeletally immature cadaveric specimens, demonstrated that the sagittal MPFL insertion consistently resided in the anterior third of the patella, averaging 21% of the total sagittal patellar width. Additionally, the distance from the MPFL insertion to the medial patellar articular cartilage edge showed minimal variation, representing a consistent intraoperative landmark for MPFL graft placement. Clinical Relevance: This research characterized MPFL insertion anatomy on the medial patella in the sagittal plane. This knowledge provides a clear target area for anatomic graft placement during MPFL reconstruction.
“I Am the Minority of the Minority of the Minority, I Can’t Help Thinking About My Brothers”: An Intersectional Approach to Self-Care Strategies Developed by LGBTQIA+ Adolescents and Young People During COVID-19 Quarantine in Brazil
Authors: Zucchi Eliana Miura , Ferraz Dulce , Unsain Ramiro Fernandez , Ferguson Laura , Bauquier Charlotte , Urbano Ayra , Dourado Inês , Préau Marie , Grangeiro Alexandre , Couto Márcia Thereza 
Published: February 2025

We aimed to understand how COVID-19 impacted LGBTQIA+ adolescents’ and young people’s well-being and to explore self-care strategies developed by them to address such effects. A qualitative investigation was conducted with adolescents and young people including 39 men who have sex with men and transgender women aged 15–22 years in Brazil. Data collection comprised digital-based diaries and semi-structured interviews and occurred during physical distancing measures. We adopted an iterative thematic analysis from an intersectional lens to examine how participants’ multiple social identities—such as gender, sexuality, race, and class—influenced their self-care practices. The process of reflecting on and adapting to COVID-19-related restrictions prompted participants to recognize experiences that impacted their well-being throughout their lives, such as stigma, discrimination, and violence. Social class emerged as the primary factor in social differentiation, rather than race, leading to varied effects of the pandemic on participants’ lives. In their quest for a sense of wholeness, participants became more critical of their relationships, often choosing to end toxic and abusive connections while seeking new sources of social support as a key strategy for protecting their well-being. Transgender participants noted that certain aesthetics within the transgender community could be oppressive rather than emancipatory. Engaging with new social media circles and participating in volunteer work were important forms of community engagement, particularly among Black participants. Future research on the long-term effects of COVID-19 on the well-being of adolescents should prioritize articulating structural drivers of inequality in qualitative health research.
Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway
Authors: Chen Qiaoli , Hao Quanxiang , Yang Yanping , Li Limei , Li Danping , Zhao Ran , Wei Wanqi , Deng Lixian , Su Jiaming , Liang Ziyuan , Tang Shiyue , Lu Yaomin , Liang Yushan , Zhang Zhe , Zhou Xiaoying , Xiao Xue , Li Ping , Huang Yi , Zhao Weilin 
Published: February 2025

Background Carboxylesterase 4A (CES4A) belongs to the member of the carboxylesterase family, yet there has been limited research into its malignant biological behavior in malignant tumors. Here, we aim to investigate the expression, cellular biological functions, and the potential underlying mechanism of CES4A in nasopharyngeal carcinoma (NPC). Method A standardized mean difference (SMD) analysis was used to analyze the dysregulation of CES4A based on the gene expression omnibus (GEO) database. qRT-PCR and immunohistochemical staining (IHC) were used to identify the mRNA and protein levels of CES4A in NPC cell lines and tissues, respectively. CCK-8, colony formation, wound healing and transwell assays were utilized to estimate cellular growth and metastasis, respectively. Western blot was conducted to evaluate the activity of PI3K/AKT signaling pathway. Result Both mRNA and protein expression of CES4A was significantly diminished both in NPC cell lines and primary tumor tissues. Ectopic expression of CES4A restrains the proliferation, colony formation, migration and invasion of NPC. Additionally, KEGG analysis based on GEO data and high-throughput transcriptome sequencing of cell lines all strongly suggested that CES4A was involved in regulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. It was observed that AKT and phosphorylated AKT were remarkably reduced in CES4A overexpressing NPC cells, indicating that PI3K/AKT signaling pathway is hindered by CES4A. Conclusion CES4A expression is silenced in NPC, functioning as a tumor suppressor by negatively modulating the PI3K/AKT signaling pathway.
Stress shielding influences shoulder function after reverse shoulder arthroplasty using a short stem at minimum 2 years follow-up and can be predicted using a preoperative planning software: A retrospective cohort study
Authors: Franceschetti Edoardo , Gregori Pietro , Laudisio Alice , De Andreis Chiara , Perricone Giovanni , Giurazza Giancarlo , Paciotti Michele , Longo Umile Giuseppe , Papalia Rocco 
Published: February 2025

Background The aim of the study was to assess if 3D CT-scan-based planification of distal filling ratio (DFR) is accurate when compared to postoperative DFR calculated on plain X-rays. A secondary aim was to investigate if an association between clinical outcomes and the degree of stress shielding (SS) exists. Methods Fifty patients with short-stem reverse shoulder arthroplasties, preoperative CT scans, and a minimum 24-month radiographic follow-up were included in the study. At 24 months follow-up, all patients were evaluated by assessing the postoperative filling ratios, the 3D DFRs, the simple shoulder test, Constant-Murley score, and visual analogue scale through a prospectively data collection and statistically analyzed. Results A correlation between the 3D DFR and SS onset (rs 0.54; P < 0.001), and between postoperative DFR and SS (rs 0.71; P < 0.001), was found. The 3D DFR and the postoperative DFR were correlated (rs 0.89; P < 0.0001). SS negatively affects the postoperative range of motion, decreasing the forward elevation of the shoulder. Conclusion The calculation of DFR based on 3D CT planning is a good predictor of humeral SS after short-stem RTAs. The presence of SS decreases clinical outcomes by lowering the anterior elevation of the shoulder. Level of evidence Case series.
Mompreneurship and resilience: Exploring entrepreneurship for mothers of children with additional needs
Authors: Casteleijn-Osorno Regina , Hytti Ulla 
Published: February 2025

By conducting a problematizing review, this study explores whether entrepreneurship could benefit mothers caring for children with additional needs (ANs). Through role conflict theory, we argue that entrepreneurship provides the time and space flexibility necessary to combine work and care roles and to experience the autonomy not available in paid employment. However, a supportive institutional framework, such as affordable child care, is needed. Based on role enrichment theory, we suggest that mothers caring for AN children possess skills, such as resilience and networking, which are beneficial to entrepreneurship. Furthermore, provided that a fair division of responsibilities exists within the household, AN children can strengthen the family unit and make it an important resource in entrepreneurship for mothers. We develop a future research agenda for mompreneurship with AN children in line with inclusive entrepreneurship. JEL CLASSIFICATION: L26 Entrepreneurship
Prevalence and burden of possible refractory chronic cough in four European countries
Authors: Domínguez-Ortega Javier , Virchow J. Christian , Guilleminault Laurent , Antonelli Incalzi Raffaele , Beyer Andrew P. , Ke Xuehua , Ding Helen , Boggs Robert 
Published: February 2025

BackgroundThis cross-sectional study estimated prevalence and health-related burden of possible refractory or unexplained chronic cough (RCC).MethodsThis secondary analysis of survey data from France, Germany, Italy, and Spain included respondents who self–reported current chronic cough (CC; cough ≥8 weeks) and no smoking/vaping, lung cancer history, interstitial lung disease, or angiotensin-converting enzyme inhibitor/oral steroid use. Respondents who scored ≥4 (of 10) on a cough severity visual analog scale and did not report “a great deal” of relief from ≥1 category of eligible medications for CC-associated conditions were included in the possible RCC group; of these, respondents who received ≥2 or 3 categories of eligible medications were also included in possible RCC subgroups 1 and 2, respectively. Remaining respondents were included in the non-RCC group. Demographics/Clinical characteristics and cough/health-related burden were assessed.ResultsOf 591 respondents with CC, 165 (27.9%) were included in the possible RCC group; 56 (9.5%) and 11 (1.9%) also met criteria for possible RCC subgroups 1 and 2, respectively. The possible RCC groupversusnon-RCC group had a higher proportion of females (66.7%versus57.3%; p=0.037), lower mean EQ-5D-5L index (0.72versus0.80;p<0.001), lower mean Leicester Cough Questionnaire score (13.49versus15.95;p<0.001), and more mean healthcare visits within the past 6 months (9.87versus6.26;p<0.001).ConclusionUp to 27.9% of this European population with CC may have RCC and experience increased health-related burden relative to non-RCC.
COMPAIR: a comparison of directly supervised clinicversusvirtually supervised home spirometry
Authors: Pradhan Ashish , Pollington Jacqui , Saralaya Dinesh , Martin Matthew J , Hughes Rod , Arya Niki , Sanders Nick , Sharifian Hoda , Locke Katharine , Bonam Matt , Harrison Tim W 
Published: February 2025

Objectivesto compare directly supervised clinic spirometry (DSCS) with virtually supervised at home spirometry (VSHS), assess the utility of AI-over-reading, and evaluate patients’ views of VSHS.MethodsA multi-centre, prospective, 8-day study was conducted in adult patients with physician-diagnosed asthma or COPD from UK primary/secondary care. Spirometry (FEV1and FVC) was performed using the NuvoAir Air Next Bluetooth® Portable Spirometer supported by trained healthcare providers (HCPs) in clinic (Days 1 and 8) and virtually supervised at home (Days 2 and 7). Over-reading was done manually and by ArtiQ.QC (Cloud-based AI). Inter-method concordance and agreement were assessed by correlation analyses and Bland-Altman plots, respectively. Participants completed a questionnaire (Day 8) to assess their views on VSHS.Results68 participants were included (n=47/21 asthma/COPD). There was excellent concordance between HCP-over-read DSCS (Day 1) and VSHS (Day 2) as indicated by intraclass correlation coefficients (ICC) [95% CI] for FEV1(0.95 [0.92, 0.97]), and FVC (0.95 [0.92, 0.97]), which were slightly higher when over-read by ArtiQ-QC (FEV1: 0.98 [0.97, 0.99]; FVC: 0.96 [0.93, 0.97]). Bland-Altman plots showed good agreement between DSCS and VSHS, for both manual and ArtiQ-QC over-read assessments, with evidence of better agreement when over-read by ArtiQ-QC. More than 95% of patients considered the NuvoAir spirometer and mobile app easy-to-use and would be happy to use it in future.ConclusionsVSHS with the NuvoAir spirometer and ArtiQ.QC over-reading offers reliable and consistent measures of lung function for research purposes and potential clinical application in a population of patients with asthma or COPD.