bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-embryonic tail development through molting of the freshwater shrimpNeocaridina denticulata
Authors: Adachi Haruhiko , Moritoki Nobuko , Shindo Tomoko , Arakawa Kazuharu 
Published: March 2024

AbstractBackgroundUnderstanding postembryonic morphogenesis through molting in arthropods has recently become a focus of developmental biology. The hierarchical mechanisms of epithelial sheet folds play a significant role in this process.Drosophilais a well-studied model for holometabolous insects, with extensive research on imaginal disc growth. While developmental processes in other arthropods have been described, live imaging of morphological changes is challenging due to the macroscopic movements and hard cuticles.Neocaridina denticulata, a crustacean, presents unique tail morphogenesis through molting, which makes it the potential model. This study investigated the development of the tail inNeocaridina denticulatathrough histological analysis andin vivolive imaging using fluorescent probes. This study also performed long-read sequencing of the whole genome for future genetic tools.ResultsThe tail ofNeocaridinawas found to undergo two major changes with the first ecdysis. Firstly, the branches of the uropods are cleared, and secondly, the telson undergoes convergent elongation. Cross-sectional analysis revealed that uropod and telson branching occurs immediately after hatching in the form of cuticle branching. The surface structure of the developmental tail suggested that telson elongation is achieved by the extension of anisotropic furrows in the cuticle during ecdysis. Anisotropy of cuticle furrows was associated with the epithelial cell shape, and the anisotropy of cell shape was found to occur during development from post-hatching. We also established anin vivolive imaging system with UV-LED resin and detected the changes of tail development over time.in vivolive imaging analysis revealed that telson contraction occurs gradually prior to ecdysis. Furthermore, we have also provided a draft genome ofNeocaridina.ConclusionNeocaridina denticulatais a valuable model for studying morphogenesis in arthropods through molting. The tail undergoes complex changes involving cuticle branching, anisotropic furrows, and cellular dynamics.in vivolive imaging system provides insights into the developmental process, and the draft genome enhances the potential for genetic tools in future studies. This research contributes to the understanding of arthropod morphogenesis and provides a foundation for further developmental and cytological investigations inNeocaridina.
Controlled Protein-Membrane Interactions Regulate Self-Organization of Min Protein Patterns
Authors: Hasani Mergime , Esch Katharina , Zieske Katja 
Published: March 2024

AbstractSelf-organizing protein patterns play an essential role in life, governing important cellular processes, such as polarization and division. While the field of protein self-organization has reached a point where basic pattern-forming mechanisms can be reconstituted in vitro using purified proteins, understanding how cells can dynamically switch and modulate these patterns, especially when transiently needed, remains an interesting frontier. Here, we demonstrate the efficient regulation of self-organizing protein patterns through modulation of simple biophysical membrane parameters. Our investigation focusses on the impact of membrane affinity changes on Min protein patterns at lipid membranes composed of E. coli lipids or minimal lipid composition and we present three major results. First, we observed the emergence of a diverse array of pattern phenotypes, ranging from waves to snowflake-like structures. Second, we establish the dependency of these patterns on the density of protein-membrane linkers. Finally, we demonstrate the fine-tuning of snow-flake-like patterns by regulating membrane charge through lipid composition. Our results demonstrate the significant influence of membrane linkage as a straightforward biophysical parameter governing protein pattern formation. Our research points towards a simple yet intriguing mechanism by which cells can adeptly tune and switch protein patterns on the mesoscale.
Transforming urban industrial landscapes through art tourism – a gentrification aesthetics model from Abu Dhabi’s case
Authors: Slak Nataša , Mura Paolo 
Published: March 2024

Purpose
This paper aims to explore the opinions of business owners in an industrial area of Abu Dhabi that could be potentially turned into an art tourism destination.

Design/methodology/approach
By mobilizing the concept of “gentrification aesthetics,” the authors use a recall technique to explore support toward art from business owners, regression analyses to understand how the type and content of art predicts gentrification support and chi-square to research the differences between respondents who support the area to become a creative place and those who do not.

Findings
A model that explains the connection between gentrification aesthetics and art tourism is presented.

Research limitations/implications
The authors’ proposed model results from testing the possibilities for expanding art tourism specifically and may not apply to other types of tourism. Future research is needed to understand whether and how the model can be applied to other forms of tourist consumption.

Practical implications
The current research presents a case study on how tourism can be strategically expanded into more rural places in a city.

Social implications
The authors found significant differences between respondents who would like to see Mussafah becoming a creative place in five years and those who believe Mussafah needs to be(come) something else.

Originality/value
While work on tourism gentrification has been conducted, the nexus between gentrification aesthetics and art tourism cannot be found. Their relation can help to expend (art) tourism from busy cultural attractions to industrial areas. The present research fills this gap.
Comparison of face-to-face and online flipped learning: academic achievement, epistemological and pedagogical beliefs
Authors: Şahin Şeyma , Kılıç Abdurrahman 
Published: March 2024

PurposeThe ultimate objective of this study is to compare the impact of face-to-face and online flipped learning on students' academic achievements and their perspectives on learning and teaching, offering valuable insights to the field.Design/methodology/approachThe study utilized a quasi-experimental research method that involves pre-test and post-test control groups.FindingsThe results indicated that face-to-face and online flipped learning positively impacted learning, with comparable contributions to academic achievement. However, we found that online flipped learning did not affect students' beliefs about learning and teaching, while face-to-face flipped learning positively influenced them.Originality/valueAs distance learning becomes increasingly important in our modern era, this research aims to explore the use of active learning methods, including discussion, writing, animation, drawing, association, analysis, knowledge measurement and games, in virtual learning environments, such as online flipped learning. The study seeks to enhance the existing literature on the impact of face-to-face and online flipped learning models on student success. Additionally, it aims to address a significant gap in the literature by determining the effect of these models on students' epistemological and pedagogical beliefs, which can impact their motivation, learning outcomes, academic achievements and decision-making processes.
Measuring supply chain finance: a study of scale development and validation in the emerging market context
Authors: Ali Zulqurnain 
Published: March 2024

Purpose
Financing remains a serious concern for firms and is considered the main hurdle in the growth and development of small and medium enterprises (SMEs). Recently, a new stream of financing (SCF; supply chain finance) has emerged to meet the financing issues of SMEs. Therefore, measuring SCF is essential to support SMEs’ operations. This study aims to develop and validate the SCF scale based on extant literature.

Design/methodology/approach
Using a mixed-method approach, this study recruited different samples of SME entrepreneurs to confirm the internal consistency, assess construct validity and check the item structure of the SCF scale in AMOS.

Findings
The outcomes of confirmatory factor analysis demonstrated the six factors of SCF (inventory financing, working capital optimization, reverse financing, fixed assets financing, logistics financing and order cycle financing) spread over 21 items. An interitem solid structure of the SCF scale offers invaluable contributions to the supply chain management literature.

Practical implications
This research supports SME entrepreneurs to obtain secure financing at the best cost, mitigating the risk of default, supporting the buyers’ payment terms, providing early payment to suppliers and strengthening the firm’s value chains. SMEs can obtain financing per their requirements to support their operational business processes. Moreover, SMEs can plan, manage and control finance-related transactional activities by correctly identifying financing solutions.

Originality/value
The present study contributes to SCM literature by developing and validating the SCF scale. To the best of the author’s knowledge, this is the first study that redefined SCF and identified its six dimensions.
Research data management competencies of researchers in selected public universities in South Africa
Authors: Mthembu Mpilo Siphamandla , Ocholla Dennis N. 
Published: March 2024

PurposeIn today's global and competitive corporate environment characterised by rapidly changing information, knowledge and technology (IKT), researchers must be upskilled in all aspects of research data management (RDM). This study investigates a set of capabilities and competencies required by researchers at selected South African public universities, using the community capability model framework (CCMF) in conjunction with the digital curation centre (DCC) lifecycle model.Design/methodology/approachThe post-positivist paradigm was used in the study, which used both qualitative and quantitative methodologies. Case studies, both qualitative and quantitative, were used as research methods. Because of the COVID-19 pandemic rules and regulations, semi-structured interviews with 23 study participants were conducted online via Microsoft Teams to collect qualitative data, and questionnaires were converted into Google Forms and emailed to 30 National Research Foundation (NRF)-rated researchers to collect quantitative data.FindingsParticipating institutions are still in the initial stages of providing RDM services. Most researchers are unaware of how long their institutions retain research data, and they store and backup their research data on personal computers, emails and external storage devices. Data management, research methodology, data curation, metadata skills and technical skills are critically important RDM competency requirements for both staff and researchers. Adequate infrastructure, as well as human resources and capital, are in short supply. There are no specific capacity-building programmes or strategies for developing RDM skills at the moment, and a lack of data curation skills is a major challenge in providing RDM.Practical implicationsThe findings of the study can be applied widely in research, teaching and learning. Furthermore, the research could help shape RDM strategy and policy in South Africa and elsewhere.Originality/valueThe scope, subject matter and application of this study contribute to its originality and novelty.
Research on interference compensation methods for color image sensors based on iterative learning
Authors: Wen Qiang , Chen Lele , Jin Jingwen , Huang Jianhao , Wan HeLin 
Published: March 2024

Purpose
Fixed mode noise and random mode noise always exist in the image sensor, which affects the imaging quality of the image sensor. The charge diffusion and color mixing between pixels in the photoelectric conversion process belong to fixed mode noise. This study aims to improve the image sensor imaging quality by processing the fixed mode noise.

Design/methodology/approach
Through an iterative training of an ergoable long- and short-term memory recurrent neural network model, the authors obtain a neural network model able to compensate for image noise crosstalk. To overcome the lack of differences in the same color pixels on each template of the image sensor under flat-field light, the data before and after compensation were used as a new data set to further train the neural network iteratively.

Findings
The comparison of the images compensated by the two sets of neural network models shows that the gray value distribution is more concentrated and uniform. The middle and high frequency components in the spatial spectrum are all increased, indicating that the compensated image edges change faster and are more detailed (Hinton and Salakhutdinov, 2006; LeCun et al., 1998; Mohanty et al., 2016; Zang et al., 2023).

Originality/value
In this paper, the authors use the iterative learning color image pixel crosstalk compensation method to effectively alleviate the incomplete color mixing problem caused by the insufficient filter rate and the electric crosstalk problem caused by the lateral diffusion of the optical charge caused by the adjacent pixel potential trap.
Speculations on the loss of regeneration derived from developmental modifications during land adaptation in some evolutionary lineages of animals
Authors: Alibardi Lorenzo 
Published: March 2024

AbstractRegeneration varies largely among metazoans. Aside molecular processes, this epiphenomenon depends on the biological complexity and evolutive history of each species during the adaptation to their specific environment. While most species adapted to marine or freshwater conditions can extensively regenerate, those adapted to terrestrial conditions and parasitism lost the ability to regenerate. They are mainly represented from ascelmintes evolving eutely and numerous arthropods and amniotes. High regeneration can only occur in water‐adapted species and requires high tissue hydration, indirect development through metamorphosis and often also presence of asexual propagation. Metamorphosis allows the anatomical‐physiological transformation of a larva in an adult through an initial destructive phase followed by a constructive (regenerative) phase. Invertebrates and vertebrates that possess genomes including metamorphic genes can re‐utilize in part or largely similar genes for the regeneration of lost organs. I submit that during land adaptation in both invertebrates and vertebrates the initial larval stages and metamorphosis were lost or altered as some key genes, including those for telomerases, could no longer be expressed in the dry environment. Consequently, also the initial regenerative ability was lost while other epiphenomena were gained, including complex immunity and behaviour but also an evident process of ageing.
Overcoming confusion and stigma in habitat fragmentation research
Authors: Riva Federico , Koper Nicola , Fahrig Lenore 
Published: March 2024

ABSTRACTAnthropogenic habitat loss is widely recognized as a primary environmental concern. By contrast, debates on the effects of habitat fragmentation persist. To facilitate overcoming these debates, here we: (i) review the state of the literature on habitat fragmentation, finding widespread confusion and stigma; (ii) identify consequences of this for biodiversity conservation and ecosystem management; and (iii) suggest ways in which research can move forward to resolve these problems.Confusion is evident from the 25 most‐cited fragmentation articles published between 2017 and 2021. These articles use five distinct concepts of habitat fragmentation, only one of which clearly distinguishes habitat fragmentation from habitat area and other factors (‘fragmentation per se’). Stigmatization is evident from our new findings that fragmentation papers are more charged with negative sentiments when compared to papers from other subfields in the environmental sciences, and that fragmentation papers with more negative sentiments are cited more.While most empirical studies of habitat fragmentation per se find neutral or positive effects on species and biodiversity outcomes, which implies that small habitat patches have a high cumulative value, confusion and stigma in reporting and discussing such results have led to suboptimal habitat protection policy. For example, government agencies, conservation organizations, and land trusts impose minimum habitat patch sizes on habitat protection. Given the high cumulative value of small patches, such policies mean that many opportunities for conservation are being missed.Our review highlights the importance of reducing confusion and stigma in habitat fragmentation research. To this end, we propose implementing study designs in which multiple sample landscapes are selected across independent gradients of habitat amount and fragmentation, measured as patch density. We show that such designs are possible for forest habitat across Earth's biomes. As such study designs are adopted, and as language becomes more precise, we expect that confusion and stigma in habitat fragmentation research will dissipate. We also expect important breakthroughs in understanding the situations where effects of habitat fragmentation per se are neutral, positive, or negative, and the reasons for these differences. Ultimately this will improve efficacy of area‐based conservation policies, to the benefit of biodiversity and people.
Aberrant TIMP‐1 production in tumor‐associated fibroblasts drives the selective benefits of nintedanib in lung adenocarcinoma
Authors: Duch Paula , Díaz‐Valdivia Natalia , Gabasa Marta , Ikemori Rafael , Arshakyan Marselina , Fernández‐Nogueira Patricia , Llorente Alejandro , Teixido Cristina , Ramírez Josep , Pereda Javier , Chuliá‐Peris Lourdes , Galbis José Marcelo , Hilberg Frank , Reguart Noemí , Radisky Derek C. , Alcaraz Jordi 
Published: March 2024

AbstractThe fibrotic tumor microenvironment is a pivotal therapeutic target. Nintedanib, a clinically approved multikinase antifibrotic inhibitor, is effective against lung adenocarcinoma (ADC) but not squamous cell carcinoma (SCC). Previous studies have implicated the secretome of tumor‐associated fibroblasts (TAFs) in the selective effects of nintedanib in ADC, but the driving factor(s) remained unidentified. Here we examined the role of tissue inhibitor of metalloproteinase‐1 (TIMP‐1), a tumor‐promoting cytokine overproduced in ADC‐TAFs. To this aim, we combined genetic approaches with in vitro and in vivo preclinical models based on patient‐derived TAFs. Nintedanib reduced TIMP‐1 production more efficiently in ADC‐TAFs than SCC‐TAFs through a SMAD3‐dependent mechanism. Cell culture experiments indicated that silencing TIMP1 in ADC‐TAFs abolished the therapeutic effects of nintedanib on cancer cell growth and invasion, which were otherwise enhanced by the TAF secretome. Consistently, co‐injecting ADC cells with TIMP1‐knockdown ADC‐TAFs into immunocompromised mice elicited a less effective reduction of tumor growth and invasion under nintedanib treatment compared to tumors bearing unmodified fibroblasts. Our results unveil a key mechanism underlying the selective mode of action of nintedanib in ADC based on the excessive production of TIMP‐1 in ADC‐TAFs. We further pinpoint reduced SMAD3 expression and consequent limited TIMP‐1 production in SCC‐TAFs as key for the resistance of SCC to nintedanib. These observations strongly support the emerging role of TIMP‐1 as a critical regulator of therapy response in solid tumors.
Nomogram to predict recurrence risk factors in patients with non‐valvular paroxysmal atrial fibrillation after catheter radiofrequency ablation
Authors: Zhao Yueyao , Zhao Lina , Huang Quanfeng , Liao Chunyan , Yuan Yao , Cao Hongjuan , Li Aiyue , Zeng Weidan , Li Sha , Zhang Bei 
Published: March 2024

AbstractBackgroundRadiofrequency catheter ablation (RFCA) is an effective method for controlling the heart rate of paroxysmal atrial fibrillation (PAF). However, recurrence is trouble under the RFCA. To gain a deeper understanding of the risk factors for recurrence in patients, we created a nomogram model to provide clinicians with treatment recommendations.MethodsA total of two hundred thirty‐three patients with PAF treated with RFCA at Guizhou Medical University Hospital between January 2021 and December 2022 were consecutively included in this study, and after 1 year of follow‐up coverage, 166 patients met the nadir inclusion criteria. Patients with AF were divided into an AF recurrence group and a non‐recurrence group. The nomogram was constructed using univariate and multivariate logistic regression analyses. By calculating the area under the curve, we analyzed the predictive ability of the risk scores (AUC). In addition, the performance of the nomogram in terms of calibration, discrimination, and clinical utility was evaluated.ResultsAt the 12‐month follow‐up, 48 patients (28.92%) experienced a recurrence of AF after RFCA, while 118 patients (71.08%) maintained a sinus rhythm. In addition to age, sex, and TRV, LAD, and TTPG were independent predictors of recurrence of RFCA. The c‐index of the nomogram predicted AF recurrence with an accuracy of .723, showing good decision curves and a calibrated nomogram, as determined by internal validation using a bootstrap sample size of 1000.ConclusionWe created a nomogram based on multifactorial logistic regression analysis to estimate the probability of recurrence in patients with atrial fibrillation 1 year after catheter ablation. This plot can be utilized by clinicians to predict the likelihood of recurrence.
Quantifying seasonal thrips population dynamics in relation to temperature and wheat senescence
Authors: Workneh Fekede , Ehrlich Brittany , Herron Benjamin , Chinnaiah Senthilraja , Gautam Saurabh , Gadhave Kiran R. , Rush Charles M. 
Published: March 2024

AbstractThe incidence of thrips in the High Plains of Texas (USA) was investigated using sticky traps during the 2021 and 2022 seasons. Yellow sticky traps were placed in wheat fields and collected and replaced weekly and thrips were counted under a dissecting scope. Weekly wheat reflectance measurements were taken using a hyperspectral radiometer from which normalized difference vegetation index (NDVI) was calculated for each measurement. Temperature (degree day) and NDVI values were then related to weekly thrips incidence using regression. Thrips incidence curvilinearly increased over time during each of the two seasons and reached a maximum in the middle of June, after which it declined sharply. There was a strong positive relationship between degree days and thrips incidence until the incidence reached a maximum, whereas the incidence was negatively related to NDVI values. Analysis of the thrips changes over time progress with the two variables together showed that degree day has greater impact on thrips incidence than NDVI. However, the steep decline in thrips abundance after its peak in mid‐June suggests that senesced wheat fields with NDVI values near zero are not significant sources of thrips, signifying the importance of wheat growth stages in the seasonal population dynamics of thrips. Overall, the 2‐year results were generally consistent in trends of thrips incidence during the season, which may need to be considered when choosing vegetable planting dates in the region.