bluuebunny/crossref_metadata_2025_split huggingface dataset:
WFSS: weighted fusion of spectral transformer and spatial self-attention for robust hyperspectral image classification against adversarial attacks
Authors: Tang Lichun , Yin Zhaoxia , Su Hang , Lyu Wanli , Luo Bin 
Published: February 2024

AbstractThe emergence of adversarial examples poses a significant challenge to hyperspectral image (HSI) classification, as they can attack deep neural network-based models. Recent adversarial defense research tends to establish global connections of spatial pixels to resist adversarial attacks. However, it cannot yield satisfactory results when only spatial pixel information is used. Starting from the premise that the spectral band is equally important for HSI classification, this paper explores the impact of spectral information on model robustness. We aim to discover potential relationships between different spectral bands and establish global connections to resist adversarial attacks. We design a spectral transformer based on the transformer structure to model long-distance dependency relationships among spectral bands. Additionally, we use a self-attention mechanism in the spatial domain to develop global relationships among spatial pixels. Based on the above framework, we further explore the influence of both spectral and spatial domains on the robustness of the model against adversarial attacks. Specifically, a weighted fusion of spectral transformer and spatial self-attention (WFSS) is designed to achieve the multi-scale fusion of spectral and spatial connections, which further improves the model’s robustness. Comprehensive experiments on three benchmarks show that the WFSS framework has superior defensive capabilities compared to state-of-the-art HSI classification methods.
Attitude modelling and real-time robust control of a 3-DoF quadcopter UAV test bench
Authors: Ahmad S.M. , Fareed S. 
Published: February 2024

AbstractIn this work, a three degrees-of-freedom (3-DoF) static quadcopter unmanned aerial vehicle (UAV) test-rig of a pendulum-type configuration is custom-designed, developed, instrumented, and interfaced with a PC. The rig serves as a test bed to develop high-fidelity mathematical models as well as to investigate autopilot designs and real-time closed-loop controllers’ performances. The Simulink Desktop Real-Time software is employed for the quadcopter’s attitude signals acquisition and real-time implementation of closed-loop controllers on a target microcontroller hardware. The mathematical models for pitch, roll, and yaw axes are derived via the first principle and validated with the experimental linear system identification (SI) techniques. Subsequently, employing the multi-parameter root contour technique, the classical proportional integral derivative (PID) controllers are designed and implemented in real-time on the quadcopter UAV test rig. This served as a benchmark controller for comparing it with an integral-based linear quadratic regulator (LQR) controller. Further, to improve the transient response of the LQR controller, a novel robust integral-based LQR controller with a feedforward term (LQR-FF) is implemented, which shows much superior performance than the benchmark and basic LQR controller. This work thus will act as a precursor for a more complex 3-DoF autopilot design of an untethered quadcopter.
Milk proteomic analysis reveals differentially expressed proteins in high-yielding and low-yielding Guanzhong dairy goats at peak lactation
Authors: Qu Yingxin , Chen Lu , Ren Xinyang , Shari Akang , Yuan Yuxin , Yu Mengqi , Xiao Haoqi , Li Guang 
Published: February 2024

AbstractThe aim of this experiment was to investigate the differential proteomic characteristics of milk from high- and low-yielding Guanzhong dairy goats during the peak lactation period under the same feeding conditions. Nine Guanzhong dairy goats with high yield (H: 3.5 ± 0.17 kg/d) and nine with low yield (L:1.2 ± 0.25 kg/d) were selected for milk proteomic analysis using tandem mass tag technology. A total of 78 differentially expressed proteins were identified. Compared with L, 50 proteins including HK3, HSPB1 and ANXA2 were significantly upregulated in H milk, while 28 proteins including LALBA and XDH were significantly downregulated. Bioinformatics analysis of the differentially expressed proteins showed that galactose metabolism, purine metabolism, glycolysis/gluconeogenesis, MAPK signaling pathway, regulation of actin cytoskeleton and other pathways were closely related to milk yield. HK3, HSPB1, ANXA2, LALBA and XDH were important candidate proteins associated with the milk production characteristics of Guanzhong dairy goats. Our data provide relevant biomarkers and a theoretical basis for improving milk production in Guanzhong dairy goats.
Transdiagnostic dimensions of symptoms and experiences associated with immune proteins in the continuity of psychosis
Authors: Corsi-Zuelli Fabiana , Quattrone Diego , Ragazzi Taciana Cristina Carvalho , Loureiro Camila Marcelino , Shuhama Rosana , Menezes Paulo Rossi , Louzada-Junior Paulo , Del-Ben Cristina Marta 
Published: February 2024

AbstractBackgroundThere is limited evidence as to whether the immune protein profile is associated with a particular symptomatology pattern across the psychosis continuum.MethodsWe estimated two bifactor models of general and specific dimensions of psychotic experiences in unaffected siblings of patients (n = 52) and community controls (n = 200), and of psychotic symptoms in first-episode psychosis (FEP) patients (n = 110). We evaluated associations between these transdiagnostic dimensions and trait (TNF-α, IFN-γ), state (IL-6, IL-1β), and regulatory (TGF-β, IL-10, IL-4) cytokines. We explored whether schizophrenia genetic liability (schizophrenia polygenic risk score; SZ-PRS) modified the associations.ResultsHigh levels of trait marker IFN-γ were associated with the severity of general psychosis dimension in the unaffected siblings and community controls, expanding to the depressive dimension in siblings and to the manic dimension in FEP. High TNF-α levels were associated with more positive psychotic experiences in unaffected siblings and manic symptoms in FEP. Low levels of state markers IL-6 and IL-1β were observed in unaffected siblings presenting more depressive experiences. Still, high levels of IL-6 and IL-1β were associated with the severity of the depressive and negative symptom dimensions at FEP. The severity of transdiagnostic dimension scores across the three groups was associated with lower regulatory cytokines. Exploratory analysis suggested that a high SZ-PRS contributed mostly to associations with psychotic dimensions.ConclusionsIFN-γ mapped onto the multidimensional expression of psychosis, reinforcing the trait concept. State markers IL-6 and IL-1β may fluctuate along the spectrum. Dysfunction in the regulatory arm may disinhibit the inflammatory system. Associations with psychotic dimensions may be more prone to SZ-PRS susceptibility.
Changes in evening-shifted loss of control eating severity following treatment for binge-eating disorder
Authors: Bottera Angeline R. , Dougherty Elizabeth N. , Forester Glen , Peterson Carol B. , Crosby Ross D. , Engel Scott G. , Crow Scott J. , Wildes Jennifer E. , Wonderlich Stephen A. 
Published: February 2024

AbstractBackgroundLoss of control eating is more likely to occur in the evening and is uniquely associated with distress. No studies have examined the effect of treatment on within-day timing of loss of control eating severity. We examined whether time of day differentially predicted loss of control eating severity at baseline (i.e. pretreatment), end-of-treatment, and 6-month follow-up for individuals with binge-eating disorder (BED), hypothesizing that loss of control eating severity would increase throughout the day pretreatment and that this pattern would be less pronounced following treatment. We explored differential treatment effects of cognitive-behavioral guided self-help (CBTgsh) and Integrative Cognitive-Affective Therapy (ICAT).MethodsIndividuals with BED (N = 112) were randomized to receive CBTgsh or ICAT and completed a 1-week ecological momentary assessment protocol at baseline, end-of-treatment, and 6-month follow-up to assess loss of control eating severity. We used multilevel models to assess within-day slope trajectories of loss of control eating severity across assessment periods and treatment type.ResultsWithin-day increases in loss of control eating severity were reduced at end-of-treatment and 6-month follow-up relative to baseline. Evening acceleration of loss of control eating severity was greater at 6-month follow-up relative to end-of-treatment. Within-day increases in loss of control severity did not differ between treatments at end-of-treatment; however, evening loss of control severity intensified for individuals who received CBTgsh relative to those who received ICAT at 6-month follow-up.ConclusionsFindings suggest that treatment reduces evening-shifted loss of control eating severity, and that this effect may be more durable following ICAT relative to CBTgsh.
Transculturation and the porosity of cultures: Fernando Ortiz
Authors: Bernasconi Robert 
Published: February 2024

AbstractFernando Ortiz introduced his account of transculturation to replace Melville Herskovits’s notion of acculturation as a way of describing the historical contact between cultures. Ortiz understood the idea of acculturation to be promoting a kind of assimilationist model very different from what he witnessed in his native Cuba. Transculturation conforms neither to the model of cosmopolitanism promoted by Kant’s universal history, nor to the kind of multiculturalism that is rooted in Herder’s rival approach to history. Instead, it presents a concept of cultural contact and cultural transformation that highlights the way the material and economic conditions of social existence shape the institutions in which cultures more narrowly conceived are embedded and relate to each other. By bringing transculturation into dialogue with the idea of the porosity of cultures initially promoted in 1925 by Walter Benjamin in his essay on Naples, we find a way to free transculturation from Ortiz’s tendency to lapse into biological metaphors with the danger of retaining a reference to cultural purity that he would not endorse. Transculturation, thus revised, recommends itself as a term helpful for thinking about a world shaped by mass migration and the new technological forms of ever more rapid cultural exchange. Properly understood, it promotes a future where openness and sharing are valued over ownership and preservation.
Benchmark-driven investment for DC pension plans
Authors: Pelsser Antoon , Yang Li 
Published: February 2024

AbstractWe investigate whether a benchmark and non-constant risk aversion affect the probability density distribution of optimal wealth at retirement. We maximize the expected utility of the ratio of pension wealth at retirement to an inflation-indexed benchmark. Together with a threshold and a lower bound, we are able to generate closed-form solutions. We find that this non-constant risk aversion type of utility could shift the probability density distribution of optimal wealth more towards the benchmark, and that the probability of achieving a certain percentage of the desired benchmark could be increased. The probability density distribution generated under constant relative risk aversion (CRRA) risk preference is more widely spread along the benchmark.
Nuclear SSR-based genetic diversity and STRUCTURE analysis of Greek tomato landraces and the Greek Tomato Database (GTD)
Authors: Bibi Androniki C. , Marountas John , Katsarou Konstantina , Kollias Anastasios , Pavlidis Pavlos , Goumenaki Eleni , Kafetzopoulos Dimitris 
Published: February 2024

AbstractTomato has been cultivated in Greece for more than 200 years, even though is not native to the country. Greece with a favourable environment all-round the year, has become a major competitor in tomato production around Europe. However, there is an increasing demand to improve tomato crop, to withstand harsh environmental conditions (extreme temperatures, salinity, etc.), and to develop high-quality final products. People have devoted a significant effort to crop improvement through phenotypic screening resulting in a large number of tomato landraces. An increasing demand to clarify the relationships among local tomato landraces and hybrids utilizing the most preferred molecular markers the simple sequence repeats (SSR-markers) is the main objective of this study. Twenty-seven tomato landraces and two tomato hybrids cultivated in Crete, Greece, were genotyped utilizing eleven simple sequence repeats (SSR) along with the Structure analysis of the germplasm. A neighbour-joining dendrogram of the 27 landraces and the two hybrids was produced. The Structure analysis indicated that nine ancestral populations are hidden inside the group of all the genotypes tested, using Evanno's method. The final objective was to make these data publicly available through the first Greek relational database (Greek Tomato Database-GTD). GTD was developed allowing the users to update and enrich the database, with new and supplemental information. This work is the first molecular fingerprint of the 27 landraces of Greece which is documented along with the phenotypic information in the GTD.
Mental Disorders in Chronic Pain Patients Seeking Treatment at a	Tertiary Pain Hospital
Authors: Thomas Mirjam V. , van Ryckeghem Dimitri M. L. , Schulz André , Müller Ruta , Lambracht Kai , Adermann Jens , Vögele Claus 
Published: February 2024

Abstract: Background: The high co-occurrence of chronic pain and mental disorders is well-established. Yet, an up-to-date account of the prevalence of mental disorders according to revised diagnostic criteria is lacking. Aims: The present study investigated the point and lifetime prevalence of a broad range of mental disorders according to DSM-5 in patients with chronic pain and examined associations of current mental health comorbidity with pain catastrophizing and health-related quality of life (HRQoL). Method: In this cross-sectional, observational study, patients with self-reported chronic pain receiving inpatient treatment at a specialized tertiary hospital were recruited for participation. Structured clinical interviews were conducted to assess current and lifetime diagnoses of mental disorders. Pain catastrophizing and HRQoL were assessed via questionnaires. Results: 145 patients (63.5% female; Mage = 54.9 years) participated in the study. 57.2% of the sample met the criteria for any current and 77.9% for any lifetime mental disorder. The most prevalent diagnostic groups of current mental disorders were substance-related and addictive disorders (26.2%), somatic symptom and related disorders (17.9%), depressive disorders (17.2%), and anxiety disorders (15.9%). Current mental health comorbidity was significantly associated with increased levels of pain catastrophizing and poorer HRQoL outcomes. Limitations: Chronic pain was only assessed by self-report, and no data regarding the exact medical diagnoses of the participants were collected. Conclusion: Comorbid mental disorders are highly prevalent in patients with chronic pain. Given the adverse effects of this comorbidity, the findings emphasize the need for addressing comorbid mental disorders in the management of chronic pain.
A Stereo Camera Simulator for Large‐Eddy Simulations of Continental Shallow Cumulus Clouds Based on Three‐Dimensional Path‐Tracing
Authors: Burchart Yannick , Beekmans Christoph , Neggers Roel 
Published: February 2024

AbstractThe complex spatial and temporal structure of cumulus clouds complicates their representation in weather and climate models. Classic meteorological instrumentation struggles to fully capture these features. Networks of multiple high‐resolution hemispheric cameras are increasingly used to fill this data gap, and provide information on this missing multi‐dimensional spatial information. In this study, a path‐tracing algorithm is used to generate virtual camera images of resolved clouds in large‐eddy simulations (LES). These images are then used as a camera network simulator, allowing reconstructions of three‐dimensional cloud edges from the model output. Because the actual LES cloud field is fully known, the combined path‐tracing and reconstruction method can be statistically analyzed. The method is applied to LES realizations of summertime shallow cumulus at the Jülich Observatory for Cloud Evolution (JOYCE), Germany, which also routinely operates a camera network. We find that the path‐tracing method allows accurate reconstruction of up to 70% of the visible cloud edges. Additional sensitivity tests show that the method is robust for changes in its hyperparameters. The sensitivity to cloud optical thickness is also investigated, finding a cloud boundary placement error of approximately 182 m. This error can be considered typical for cloud boundary reconstruction using real stereo camera imagery. The results provide proof of principle for future use of the method for evaluating LES clouds against camera network imagery, and for further optimizing the configuration of such camera networks.
Anomalous Adsorption of PFAS at the Thin‐Water‐Film Air‐Water Interface in Water‐Unsaturated Porous Media
Authors: Zhang Wenqian , Guo Bo 
Published: February 2024

AbstractPer‐ and poly‐fluoroalkyl substances (PFAS) are interfacially‐active contaminants that adsorb at air‐water interfaces (AWIs). Water‐unsaturated soils have abundant AWIs, which generally consist of two types: one is associated with the pendular rings of water between soil grains (i.e., bulk AWI) and the other arises from the thin water films covering the soil grains. To date, the two types of AWIs have been treated the same when modeling PFAS retention in vadose zones. However, the presence of electrical double layers of soil grain surfaces and the subsequently modified chemical potential of PFAS at the AWI may significantly change the PFAS adsorption at the thin‐water‐film AWI relative to that at the bulk AWI. Given that thin water films contribute to over 90% of AWIs in the vadose zone under many field‐relevant wetting conditions, it is critical to quantify the potential anomalous adsorption of PFAS at the thin‐water‐film AWI. We develop a thermodynamic‐based mathematical model to quantify this anomalous adsorption. The model couples the chemical equilibrium of PFAS with the Poisson‐Boltzmann equation that governs the distribution of electrical potential in a thin water film. Our model analyses suggest that PFAS adsorption at thin‐water‐film AWI can deviate significantly (up to 82%) from that at bulk AWIs. The deviation increases for lower porewater ionic strength, thinner water film, and higher soil grain surface charge. These results highlight the importance of accounting for the anomalous adsorption of PFAS at the thin‐water‐film AWI when modeling PFAS fate and transport in the vadose zone.
Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes
Authors: Zorko Nicholas A. , Makovec Allison , Elliott Andrew , Kellen Samuel , Lozada John R. , Arafa Ali T. , Felices Martin , Shackelford Madison , Barata Pedro , Zakharia Yousef , Narayan Vivek , Stein Mark N. , Zarrabi Kevin K. , Patniak Akash , Bilen Mehmet A. , Radovich Milan , Sledge George , El-Deiry Wafik S. , Heath Elisabeth I. , Hoon Dave S. B. , Nabhan Chadi , Miller Jeffrey S. , Hwang Justin H. , Antonarakis Emmanuel S. 
Published: February 2024

Abstract

Background
Natural killer (NK) cells are non-antigen specific innate immune cells that can be redirected to targets of interest using multiple strategies, although none are currently FDA-approved. We sought to evaluate NK cell infiltration into tumors to develop an improved understanding of which histologies may be most amenable to NK cell-based therapies currently in the developmental pipeline.

Methods
DNA (targeted/whole-exome) and RNA (whole-transcriptome) sequencing was performed from tumors from 45 cancer types (N = 90,916 for all cancers and N = 3365 for prostate cancer) submitted to Caris Life Sciences. NK cell fractions and immune deconvolution were inferred from RNA-seq data using quanTIseq. Real-world overall survival (OS) and treatment status was determined and Kaplan–Meier estimates were calculated. Statistical significance was determined using X2 and Mann–Whitney U tests, with corrections for multiple comparisons where appropriate.

Results
In both a pan-tumor and prostate cancer (PCa) -specific setting, we demonstrated that NK cells represent a substantial proportion of the total cellular infiltrate (median range 2–9% for all tumors). Higher NK cell infiltration was associated with improved OS in 28 of 45 cancer types, including (PCa). NK cell infiltration was negatively correlated with common driver mutations and androgen receptor variants (AR-V7) in primary prostate biopsies, while positively correlated with negative immune regulators. Higher levels of NK cell infiltration were associated with patterns consistent with a compensatory anti-inflammatory response.

Conclusions
Using the largest available dataset to date, we demonstrated that NK cells infiltrate a broad range of tumors, including both primary and metastatic PCa. NK cell infiltration is associated with improved PCa patient outcomes. This study demonstrates that NK cells are capable of trafficking to both primary and metastatic PCa and are a viable option for immunotherapy approaches moving forward. Future development of strategies to enhance tumor-infiltrating NK cell-mediated cytolytic activity and activation while limiting inhibitory pathways will be key.
Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity
Authors: Zhou Jun , Liu Jiaqi , Wang Bingjing , Li Nan , Liu Juan , Han Yanmei , Cao Xuetao 
Published: February 2024

AbstractMemory CD8+ T cell generation is crucial for pathogen elimination and effective vaccination against infection. The cellular and molecular circuitry that underlies the generation of memory CD8+ T cells remains elusive. Eosinophils can modulate inflammatory allergic responses and interact with lymphocytes to regulate their functions in immune defense. Here we report that eosinophils are required for the generation of memory CD8+ T cells by inhibiting CD8+ T cell apoptosis. Eosinophil-deficient mice display significantly impaired memory CD8+ T cell response and weakened resistance against Listeria monocytogenes (L.m.) infection. Mechanistically, eosinophils secrete interleukin-4 (IL-4) to inhibit JNK/Caspase-3 dependent apoptosis of CD8+ T cells upon L.m. infection in vitro. Furthermore, active eosinophils are recruited into the spleen and secrete more IL-4 to suppress CD8+ T cell apoptosis during early stage of L.m. infection in vivo. Adoptive transfer of wild-type (WT) eosinophils but not IL-4-deficient eosinophils into eosinophil-deficient mice could rescue the impaired CD8+ T cell memory responses. Together, our findings suggest that eosinophil-derived IL-4 promotes the generation of CD8+ T cell memory and enhances immune defense against L.m. infection. Our study reveals a new adjuvant role of eosinophils in memory T cell generation and provides clues for enhancing the vaccine potency via targeting eosinophils and related cytokines.