bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer vision for automated seizure detection and classification: A systematic review
Authors: Brown Brandon M. , Boyne Aidan M. H. , Hassan Adel M. , Allam Anthony K. , Cotton R. James , Haneef Zulfi 
Published: March 2024

AbstractComputer vision (CV) shows increasing promise as an efficient, low‐cost tool for video seizure detection and classification. Here, we provide an overview of the fundamental concepts needed to understand CV and summarize the structure and performance of various model architectures used in video seizure analysis. We conduct a systematic literature review of the PubMed, Embase, and Web of Science databases from January 1, 2000 to September 15, 2023, to identify the strengths and limitations of CV seizure analysis methods and discuss the utility of these models when applied to different clinical seizure phenotypes. Reviews, nonhuman studies, and those with insufficient or poor quality data are excluded from the review. Of the 1942 records identified, 45 meet inclusion criteria and are analyzed. We conclude that the field has shown tremendous growth over the past 2 decades, leading to several model architectures with impressive accuracy and efficiency. The rapid and scalable detection offered by CV models holds the potential to reduce sudden unexpected death in epilepsy and help alleviate resource limitations in epilepsy monitoring units. However, a lack of standardized, thorough validation measures and concerns about patient privacy remain important obstacles for widespread acceptance and adoption. Investigation into the performance of models across varied datasets from clinical and nonclinical environments is an essential area for further research.
The elusive nature of neutrality: The role of values in couple therapy
Authors: Feldman Tamara 
Published: March 2024

AbstractThis paper will explore the role of the therapist's values in couple therapy and the challenge these values pose to therapeutic neutrality. It will illuminate how the therapist's values shape what is considered healthy and unhealthy, functional and dysfunctional, and hence frame the problem the couple therapist seeks to treat. Values have particular relevance for couple treatment because the conversations the couple therapist facilitates may unwittingly privilege one partner's needs and wishes over the other's, creating the potential for therapeutic misalliances. This paper will explore common values and their impact on treatment, including the values of monogamy, gender equity, and talk intimacy (emotional expression as a path to intimacy). It will conclude by discussing how couple therapists can avoid partisanship with one partner and maintain a balanced approach in their couple work.
Detected and projected temperature changes in the area of Mediterranean Montenegro
Authors: Burić Dragan 
Published: March 2024

AbstractThe goal of this research is to present the results of a detailed analysis of detected and projected temperature changes in Montenegro. A total of 10 temperature parameters from 18 meteorological stations were used. Initially, an analysis of temperature changes during the instrumental period (1961–2020) was conducted, followed by the results of high‐resolution (12.5 km) bias‐corrected projections from the regional ALADIN, REMO and CCLM4 models for the period 2021–2100, according to the RCP4.5 and RCP8.5 scenarios (representative concentration pathways). The simple difference method and trend method were employed for research purposes. Compared with the period 1961–1990, the highest temperature increase during 1991–2020 is observed in summer (TSu), while the rates of increase were slower in spring, winter and autumn (TSp, TW and TA). The average annual maximum temperature (TYx) registered a higher increase compared with the average minimum (TYn). Frosty days (FD) decreased, while the number of summer and tropical days (SU and TD) increased. The projection results indicate that the period 2021–2050 is expected to be warmer, the period 2051–2080 even warmer, and the period 2081–2100 is expected to be the warmest. In the last analysed period (2081–2100), according to the RCP8.5 scenario, the average TSu is expected to be higher by 3.7–4.6°C (CCLM4), 4.1–4.7°C (ALADIN) and 4.7–5.8°C (REMO), with an anticipated increase in TW ranging between 3.3–4.5°C (ALADIN), 3.6–5.4°C (CCLM4) and 3.4–5.6°C (REMO). In the period 2021–2100, according to the RCP4.5 scenario, the expected average trend values for TYx (TYn) are expected to be (°C/decade) 0.24 (0.26), 0.16 (0.12) and 0.20 (0.23) for the ALADIN, REMO and CCLM4 models, respectively, and according to the RCP8.5 scenario, 0.47 (0.52), 0.63 (0.57) and 0.51 (0.53), respectively. These findings have implications for planning mitigation and adaptation measures to address climate change, particularly in strategic economic sectors such as tourism, agriculture and water management in Montenegro.
A data‐driven approach to improve online consumer subscriptions by combining data visualization and machine learning methods
Authors: Fernandes Elizabeth , Moro Sérgio , Cortez Paulo 
Published: March 2024

AbstractEffective online consumer research helps companies on defining a successful strategy to increase user loyalty and shape brand engagement. Digital innovation introduced a dramatic change in businesses, particularly in the online news industry. Content consumers have a wide offer across different channels which increase the digital challenge for online news media companies to retain their readers and convert them into online subscribers. Furthermore, digital news publishers often strive to balance revenue sources in online business models. Thus, this study fills a gap in the literature on media consumer research by proposing a data‐driven approach that combines two machine learning (ML) models to allow managers dynamically improve their marketing and editorial strategies. Firstly, the authors present an online user profiling to identify consumer segments based on the interplay between several engagement’ variables substantiated in the literature research. Second, as few studies have explored the factors influencing users' intention to pay for such services, the eXtreme Gradient Boosting ML algorithm identifies the predictors of consumer's willingness to pay. Third, a dashboard presents the key performance indicators across the audience funnel. Thus, practical implications and business suggestions are presented in a two‐fold strategy to maximize revenue from digital subscriptions and advertising. Findings provide new insights into an engagement approach and the relation to acquire a digital subscription in online content platforms. We believe that the provided recommendations are potentially useful to help marketing and editorial teams to manage their customer engagement process across the funnel in a more efficient way.
Factors shaping the adoption of sustainable vegan diets
Authors: Shah Sweety , Thanki Joshi Heena 
Published: March 2024

AbstractThe quality and choices of food contribute significantly to human well‐being and support the development of healthy communities worldwide. Despite being the world's largest vegetarian nation, India predominantly follows lacto‐vegetarianism, allowing dairy consumption and creating a distinct dietary landscape shaped by influences from religious, social, and cultural beliefs. This complexity, where dairy and cultural‐religious factors play pivotal roles, makes India a compelling and unique case for understanding the intricacies of adopting vegan dietary preferences. In the present study, an integrated model derived from the health belief model (HBM), the value attitude behavior (VAB) model, and social stigma was adopted as the theoretical framework. The study analyses the interactive effect of perceived benefits, barriers, environmental beliefs, health beliefs, and anti‐speciesism values, with the novel inclusion of social stigma as an independent variable affecting attitudes and intentions toward adopting a vegan diet. To achieve its objective, the study employed a quantitative methodology, recording consumers' responses through a structured questionnaire. The analysis encompassed 504 valid responses from Indian consumers from diverse backgrounds and varied locations. The result unveiled several noteworthy and unique trends. It was found that perceived benefits had a positive impact, while perceived barriers had a negative impact on the health beliefs associated with a vegan diet. Environmental beliefs, health beliefs, and anti‐speciesism values exhibited a positive influence on individuals' attitudes toward adopting a vegan diet. Conversely, social stigma had a negative impact on attitudes toward a vegan diet. Attitude emerged as a pivotal mediator, connecting the social stigma to the vegan diet adoption behavior. The findings of the study offer valuable insights for policymakers, manufacturers, and marketers seeking to encourage the adoption of vegan diets in countries with predominantly vegetarian populations. Additionally, the study puts forth actionable strategies, outlined as implications to promote the widespread adoption of the vegan diet.
Validation study on the 2 mm diameter cutoff in lymph node‐positive cases following radical prostatectomy in accordance with the AJCC/UICC TNM 8th edition: Real‐world data analysis from a Japanese cohort
Authors: Kato Masashi , Shiota Masaki , Kimura Takahiro , Hanazawa Ryoichi , Hirakawa Akihiro , Takamatsu Dai , Tashiro Kojiro , Matsui Yoshiyuki , Hashine Katsuyoshi , Saito Ryoichi , Yokomizo Akira , Yamamoto Yoshiyuki , Narita Shintaro , Hashimoto Kohei , Matsumoto Hiroaki , Akamatsu Shusuke , Nishiyama Naotaka , Eto Masatoshi , Kitamura Hiroshi , Tsuzuki Toyonori ,   the Japanese Urological Oncology Group
Published: March 2024

ObjectivesThe American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) 8th edition has proposed micrometastasis as a lymph node metastasis (LN+) of diameter ≤2 mm in prostate cancer. However, supporting evidence has not described. We evaluated LN+ patients' survival after radical prostatectomy (RP) based on the LN maximum tumor diameter (MTD).MethodsData from 561 LN+ patients after RP and pelvic LN dissection (PLND) treated between 2006 and 2019 at 33 institutions were retrospectively investigated. Patients were stratified by a LN+ MTD cutoff of 2 mm. Outcomes included castration resistance‐free survival (CRFS), metastasis‐free survival (MFS), cancer‐specific survival (CSS), and overall survival (OS).ResultsIn total, 282 patients were divided into two groups (LN+ MTD >2 mm [n = 206] and ≤2 mm [n = 76]). Patients of LN+ status >2 mm exhibited significantly decreased CRFS and MFS, and poorer CSS and OS. No patients developed CRPC in the LN+ status ≤2 mm group when the PLND number was ≥14. Multivariate analysis showed the number of LN removed, RP Gleason pattern 5, and MTD in LN+ significantly predicted CRFS.ConclusionsPatients of LN+ status ≤2 mm showed better prognoses after RP. In all the patients in the ≤2‐mm group, the progression to CRPC could be prevented with appropriate interventions, particularly when PLND is performed accurately. Our findings support the utility of the pN substaging proposed by the AJCC/UICC 8th edition; this will facilitate precision medicine for patients with advanced prostate cancer.
Clinical efficacy of crushed prednisolone and hydrocolloid powder in the primary treatment of peristomal pyoderma gangrenosum and correlation to in vitro drug release data
Authors: Pearson Wendy Ann , Prentice David Andrew , Lim Lee Yong , Gianoncelli Olivia , Hashiguchi Alice , Parisella Tahlia Kate , Ta Jade Thien 
Published: March 2024

AbstractWe evaluated the primary application of crushed prednisolone combined with hydrocolloid powder for clinically diagnosed peristomal pyoderma gangrenosum (PPG). We present our data on this cohort and follow‐up of our previous patients. Of the 23 patients who were commenced on this regime, 18 healed (78%). Twenty‐two patients commenced on this regime as the primary treatment for their PPG, and for one, it was a rescue remedy after failed conventional therapy. Four patients with significant medical comorbidities failed to heal and one had their stomal reversal surgery before being fully healed. The proposed treatment regime for PPG is demonstrated to be effective, inexpensive and able to be managed in the patient's usual home environment. In vitro drug release analysis was undertaken, and data are presented to provide further insights into the efficacy of this regime.
Rhizoma Paridis saponins attenuate Gram‐negative bacteria‐induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways
Authors: Yang Yang , Wang Chaofan , Wang Juan , Yang Lingli , Lv Zheng , An Quan , Wang Yiming , Shao Xue , Wang Fei , Huo Tong , Liu Jiali , Luo Haoshu , Quan Qianghua 
Published: March 2024

AbstractAcne vulgaris represents a chronic inflammatory condition, the pathogenesis of which is closely associated with the altered skin microbiome. Recent studies have implicated a profound role of Gram‐negative bacteria in acne development, but there is a lack of antiacne agents targeting these bacteria. Polyphyllins are major components of Rhizoma Paridis with great anti‐inflammatory potential. In this study, we aimed to evaluate the antiacne effects and the underlying mechanisms of PPH and a PPH‐enriched Rhizoma Paridis extract (RPE) in treating the Gram‐negative bacteria‐induced acne. PPH and RPE treatments significantly suppressed the mRNA and protein expressions of interleukin (IL)‐1β and IL‐6 in lipopolysaccharide (LPS)‐induced RAW 264.7 and HaCaT cells, along with the intracellular reactive oxygen species (ROS) generation. Furthermore, PPH and RPE inhibited the nuclear translocation of nuclear factor kappa‐B (NF‐κB) P65 in LPS‐induced RAW 264.7 cells. Based on molecular docking, PPH could bind to kelch‐like ECH‐associated protein 1 (KEAP1) protein. PPH and RPE treatments could activate nuclear factor erythroid 2‐related factor 2 (NRF2) and upregulate haem oxygenase‐1 (HO‐1). Moreover, RPE suppressed the mitogen‐activated protein kinase (MAPK) pathway. Therefore, PPH‐enriched RPE showed anti‐inflammatory and antioxidative effects in vitro, which is promising for alternative antiacne therapeutic.
Diabetes treatment by conversion of gut epithelial cells to insulin‐producing cells
Authors: Accili Domenico , Talchai Shivatra C , Bouchi Ryotaro , Lee April Yun‐Kyoung , Du Wen , Kitamoto Takumi , McKimpson Wendy M , Belvedere Sandro , Lin Hua V 
Published: March 2024

AbstractInsulin‐deficient (type 1) diabetes is treated by providing insulin to maintain euglycemia. The current standard of care is a quasi‐closed loop integrating automated insulin delivery with a continuous glucose monitoring sensor. Cell replacement technologies are advancing as an alternative treatment and have been tested as surrogates to cadaveric islets in transplants. In addition, immunomodulatory treatments to delay the onset of type 1 diabetes in high‐risk (stage 2) individuals have gained regulatory approval. We have pioneered a cell conversion approach to restore insulin production through pharmacological conversion of intestinal epithelial cells into insulin‐producing cells. We have advanced this approach along a translational trajectory through the discovery of small molecule forkhead box protein O1 inhibitors. When administered to different rodent models of insulin‐deficient diabetes, these inhibitors have resulted in robust glucose‐lowering responses and generation of insulin‐producing cells in the gut epithelium. We review past work and delineate a path to human clinical trials.
Seeing beyond skin deep: High‐resolution ultrasound in dermatology—A comprehensive review and future prospects
Authors: Liu Zhao Feng , Chew Christopher Y. , Honavar Shreyas , Maxwell Andrew , Sylivris Amy , Sheridan Adam 
Published: March 2024

AbstractHigh‐resolution ultrasound (HRUS), operating at frequencies of 20–25 MHz, is a non‐invasive imaging tool that offers dermatologists the ability to visualize structures beneath the skin surface. The objective of this review is to present a comprehensive overview of HRUS applications, emphasising its utility in diagnosing, characterising and managing various dermatological conditions. We undertook a comprehensive literature review on the dermatological application of HRUS across Medline, Embase and Cochrane Library databases, while also incorporating our own clinical experience of over 16 years with the tool. In normal skin, the epidermis and dermis are hyperechoic, and the subcutaneous layer is hypoechoic. Basal cell carcinomas appear hypoechoic with irregular margins, while the presence of hyperechoic inclusion bodies suggests aggressive pathology. Squamous cell carcinomas pose challenges due to acoustic shadow artefacts from the thickened stratum corneum. Melanomas are homogenous hypoechoic lesions, with HRUS used to accurately predict Breslow thickness. HRUS provides dermatologists with a valuable adjunct to traditional clinical examination. Future advancement in image resolution and the standardisation of diagnostic parameters may further expand its utility.
Long‐term effects of management intensity and bioclimatic variables on leatherjacket (Tipula paludosa Meigen) populations at farm scale
Authors: Moffat Aisling , Cole Lorna , Lacey Seán , Harrison Billy , Konkolewska Agnieszka , McCracken Davy , Evans Andy K. , Gaffney Michael T. , Brennan Fiona , Jackson Gail E. , McNamara Louise 
Published: March 2024

AbstractLeatherjackets (Tipula spp.) are soil‐dwelling pests associated with agriculture. Land management decisions made at farm scale can have subsequent effects on their populations. Between 1980 and 2020, surveys were conducted across Scotland to collect field histories and larval population data from grassland farms. To assess the impact of management and bioclimatic factors on leatherjacket occurrence over time, this study investigated data from fields continuously sampled between 2009 and 2018. We utilized a Generalized Linear Mixed‐Effect Model on a dataset of 61 fields on 19 farms. Results indicated three significant factors affecting larval populations; field size, grazing type and application of insecticides or herbicides (referred to collectively as pesticides). Larval populations were significantly lower in fields that were larger in size and under sheep grazing, compared to no grazing. Pesticide application also caused a significant reduction in larval populations. Management variables were amalgamated to create a Management Intensity Index, revealing significantly increased larval populations under low‐management systems. These results, coupled with significant effects of bioclimatic variables, pinpoint predictive signals for high infestations and potential routes for control strategies.
Dissecting the Long‐Term Performance of the Chinese Stock Market
Authors: ALLEN FRANKLIN , QIAN JUN (QJ) , SHAN CHENYU , ZHU JULIE LEI 
Published: March 2024

ABSTRACTDomestically listed Chinese (A‐share) firms have lower stock returns than externally listed Chinese, developed, and emerging country firms during 2000 to 2018. They also have lower net cash flows than matched unlisted Chinese firms. The underperformance of both stock and accounting returns is more pronounced for large A‐share firms, while small firms show no underperformance along either dimension. Investor sentiment explains low stock returns in the cross‐country and within‐A‐share samples. Institutional deficiencies in listing and delisting processes and weak corporate governance in terms of shareholder value creation are consistent with the underperformance in stock returns and net cash flows.
Parent‐child conflict in Mexican‐origin families: Charting development from adolescence to young adulthood
Authors: Son Daye , Updegraff Kimberly A. , Umaña‐Taylor Adriana J. 
Published: March 2024

AbstractGrounded in developmental and cultural‐ecological perspectives, the current study examined trajectories of parent‐youth conflict regarding everyday issues across adolescence and into young adulthood. Data came from 246 Mexican‐origin families in the southwestern United States with younger siblings (51% female, Mage = 12.8, SD = 0.58), older siblings (Mage = 15.5, SD = 1.57), mothers (Mage = 39.0; SD = 4.6), and fathers (Mage = 41.7; SD = 5.8) and were collected at four time points over an 8‐year period. Multilevel modeling analyses revealed linear declines in mother‐youth and father‐youth conflict across ages 12–22. Youth, but not parent, familism values were associated with variation in parent‐youth conflict. This study extends understanding of culturally and developmentally salient processes of mother‐youth and father‐youth relationships in Mexican‐origin families.
Untreated Allergy Among Middle School Students: Associations with Socioeconomic Adversities and Academic, Behavior, and Health Difficulties
Authors: Chau Kénora , Chau Nearkasen 
Published: March 2024

ABSTRACTBACKGROUNDMany adolescents with allergy do not receive physician treatment (allergyuntreated). We explored its association with socioeconomic adversities and academic‐behavior‐health difficulties, which remain unaddressed.METHODSThis cross‐sectional school‐based‐population study compared the above factors of middle‐school adolescents with allergyuntreated and those with treated allergy (allergytreated) (mean age = 13.5 ± 1.2) from north‐eastern France. Participants completed a questionnaire collecting socioeconomic adversities (nonintact family, low parents' education, insufficient family income, poor social support, suffered verbal/physical violence, and sexual abuse), low academic performance, excessive screen time, substance use, sleep difficulty, poor physical health, depressive symptoms, suicide attempt, poor quality of life, and allergytreated/allergyuntreated.RESULTSLogistic regression models showed that allergyuntreated was associated with all the factors considered (sex‐age‐class‐level‐adjusted odds ratio (saclOR) reaching 3.94, p < .001) and the risk score (number of main criteria: suffered sexual abuse, excessive screen time, poor quality of life, cannabis use, low parents' education, and poor social support): saclOR 4.75, 9.23, 15.64, and 31.73 (p < .001) for risk scores 1, 2, 3, and ≥4, versus risk score = 0 (pseudo‐R2 = 11.1%).CONCLUSIONSSocioeconomic adversities and academic‐behavior‐health difficulties may be used to detect adolescents with allergyuntreated for care.
Social network analysis, habitus and the field of literary activity
Authors: Li Li , Corbett John 
Published: March 2024

AbstractSocial network analysis that draws upon the correspondence of writers has the potential to indicate aspects of the writers' habitus, that is, the economic, social and cultural capital represented by the relations between authors, poets and dramatists, and their correspondents. Social network analysis can visualise and reveal otherwise covert aspects of the field of literary activity. In particular, it can show the flow of cultural, symbolic, social and economic capital through the literary ecosystem. The article presents an introduction to social network analysis, describes a modest case study, and identifies possible future research directions.