bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sinonasal diffuse large B-cell lymphoma: own clinical observation and literature review
Authors: Mingalimov M. A. , Baryakh E. A. , Kochneva O. L. , Misyurina E. N. , Polyakov Yu. Yu. , Zhelnova E. I. , Yatskov K. V. , Makeshova A. B. , Tolstykh T. N. , Chudnova T. S. , Ivanova D. D. , Lebedev D. V. , Zotina E. N. , Gagloeva D. E. , Beregov M. M. , Mamatturdiev E. A. , Samsonova I. V. , Lysenko M. A. 
Published: April 2024

Diffuse large B-cell lymphoma is the most common immunomorphological variant of lymphoma in adults. Extranodal lesions are observed in a third of patients at the disease onset. The organs most often involved are the gastrointestinal tract, testicles, bones, thyroid gland, and skin. Primary involvement of the nasal cavity and paranasal sinuses occur extremely rarely and cause diagnostic and therapeutic difficulties.The article demonstrates a rare clinical case of newly diagnosed diffuse large B-cell lymphoma with sinonasal tract involvement. It took 6 months to verify the final diagnosis. At the moment, the induction stage of treatment for diffuse large B-cell lymphoma continues, the achieved complete metabolic response is maintained.
Nijmegen syndrome in childhood: a clinical case
Authors: Malyuzhinskaya N. V. , Morgunova M. A. , Petrova I. V. , Polyakova O. V. , Samokhvalova V. V. , Bayurov A. V. , Klitochenko G. V. 
Published: April 2024

Nijmegen syndrome is a rare monogenic pathology with an autosomal recessive type of inheritance. The disease is manifested by congenital developmental anomalies and microcephaly, primary immunodeficiency, frequent recurrent viral and bacterial infections, retardation in physical and neuropsychic development. In the medical literature, 150 cases of the syndrome are described; pathology occurs more often among the Slavic population. Nijmegen syndrome belongs to a group of diseases with chromosomal instability. The pathogenetic feature of the syndrome is congenital immunodeficiency of the humoral (B-lymphocytes) and cellular (T-lymphocytes) components. According to statistics, 40 % of children with Nijmegen syndrome are diagnosed with malignant neoplasms. lymphoid tissue is more often affected (non-Hodgkin’s B and T-cell lymphomas, acute lymphoblastic leukemia), and the development of solid neoplasia is also possible. To diagnose Nijmegen syndrome, in addition to assessing the patient clinical status, it is necessary to conduct an extended immunological examination with the determination of immunoglobulins A, M, G and molecular genetic studies.The article presents a clinical case of diagnosis and treatment of Nijmegen syndrome in childhood.
Research tools for studying modern trends in the implementation of ESG practices in Russian companies
Authors: Tkachenko I. N. , Ramenskaya L. A. 
Published: April 2024

Purpose: is to test the research tools for studying modern trends in the implementation of ESG practices and their effectiveness in Russian companies. Methods: this article examines the applicability of the research tools for analyzing the activities of organizations in the direction of the ESG agenda. We analyzed such tools as comparative analysis of fi nancing ESG projects, content analysis of report texts, regression analysis of the relationship between the ESG ratings and the fi nancial performance of the company. A comparative analysis of methods was carried out based on the results of appropriation of instruments. Results: the main result of the reporting analysis is the identifi cation of a trend towards reducing disclosure of information on the financing of ESG projects. We can identify main areas of investment in requests from external and internal stakeholders based on available financing information. The conclusion about the increase in mentions of social projects and initiatives in the fi eld of environmental protection based on a content analysis results. We also identifi ed the highest priority areas for each of the ESG components. The main priorities are: the social agenda – "employee welfare"; responsible attitude to the environment – "reduction of greenhouse gas emissions", "energy–efficient materials and technologies", "waste management" and "water consumption"; corporate governance – "observance of shareholders' rights". The hypothesis about the positive impact of ESG rating on company value confi rmed. There was a positive relationship between a company's environmental performance and value, as well as a negative relationship between value and social performance. Conclusions and Relevance: despite the challenges and sanctions restrictions, Russian companies continue to be active in the ESG field. For a more complete analysis of the ESG projects and their coverage in non-financial reporting, it is preferable to use a combination of research tools.
The Odyssey of Lupus
Authors: Ashinze Patrick 
Published: April 2024

It begins with a blush,the kind that doesn’t vanish,even with sadnessor the hush of immune calmers.
then, it upscalesinto a flash of lightning,stabbing the skies with boltsof redness and irritation,making the body a slow, feralpoison unto its own beauty
until all the cells, all the pillars that hold the fortall zones and hopes are friedand the bored earth is forcedout of pity and derisionto eat cold dinner at breakfast.
MAKNA FILOSOFIS DALAM UBARAMPE TRADISI JENANG SURA DI DUKUH TIPES KECAMATAN SERENGAN SURAKARTA
Authors: Saputra Yanuar Yoga , Wijayanti Kenfitria Diah , Fitriana Tya Resta 
Published: April 2024

<p>Penelitian ini bertujuan untuk (1)menemukan ubarampe dalam tradisi Jenang Sura, (2)menganalisa makna filosofis dalam ubarampe Jenang Sura. Pendekatan penelitian ini adalah <em>Semiotika Roland Barthes. </em>Data yang digunakan berupa foto ubarampe dengan sumber data penelitian berupa kamus bahasa Jawa dan hasil wawancara. Teknik pengumpulan data menggunakan dokumentasi tentang ubarampe Jenang Sura. Teknik analisis yang digunakan teori <em>Spreadly </em>yang terbagi dengan domain-domain tertentu yang bisa menarik sebuah kesimpulan. Berdasarkan hasil analisis ditemukan hasil penelitian (1) menyebutkan wujud ubarampe dalam tradisi Jenang Sura, (2) memaparkan makna filosofis yang terkandung dalam ubarampe tradisi Jenang Sura.</p><p> </p><p> </p>
IMPLEMENTASI MODEL PEMBELAJARAN KOOPERATIF TIME TOKEN ARENDS TEKS PAWARTA PADA SISWA KELAS X SMAN 1 KARANGGEDE
Authors: Rahmawati Linda Saviera , Setiawan Budi , Rahmat Rahmat 
Published: April 2024

<p>Dalam pelajaran bahasa siswa dituntut terampil berbicara. Namun masih banyak siswa yang kurang memiliki ketarampilan berbicara bahasa Jawa. Guru memilih model pembelajaran yang menarik perhatian siswa. Model pembelajaran yang digunakan yaitu kooperatif tipe <em>Time Token Arends. </em>Penelitian betujuan untuk<em> </em>mengetahui pelaksanaan pembelajaran model kooperatif tipe <em>Time Token Arends</em>.</p><p>Penelitian ini menggunakan metode kualitatif yang berlandaskan pada filsafat postpositivisme untuk meneliti keadaan objek yang alamiah, dimana peneliti sebagai instrumen kunci. Teknik pengumpulan data dengan observasi, wawancara, dan studi dokumen. Analisis data menggunakan teknik triangulasi.</p><p>Penelitian yang dilakukan di SMA Negeri 1 Karanggede, bahwa langkah-langkah Pembelajaran <em>Time Token Arens</em> meliputi: guru membentuk kelompok beranggota 4 siswa, membagi kupon berbicara kepada seluruh peserta didik dan teks <em>pawarta</em> pada setiap kelompok, guru memberikan kesempatan pada kelompok untuk berdiskusi, guru mempersilakan perwakilan kelompok untuk berbicara secara bergantian, guru mempersilakan peserta didik yang lain untuk menanggapi, guru memberikan kesempatan satu kali bagi tiap peserta didik untuk berbicara.</p><p>Hambatannya guru kesulitan membagi waktu, solusinya dibagi menjadi dua pertemuan. Guru harus menyiapkan media pembelajaran yang banyak memakan waktu dan tenaga, solusinya melibatkan siswa dalam mencari teks <em>pawarta</em>. Siswa merasa dibatasi waktu untuk menyampaikan tanggapan, solusinya dengan penambahan waktu, yang baerasal dari daerah lain, solusinya dengan pelatihan individual.</p>
Synthesis of the Genome of Bacteriophage N4
Authors: Fisunov G. Yu. , Semashko T. A. , Evsyutina D. V. , Tsoy E. A. , Kharrasov D. R. , Gumayunova K. S. , Tuchkov I. V. , Nikiforov K. A. , Rybal’chenko D. A. , Kutyrev V. V. , Govorun V. M. 
Published: April 2024

At present, bacteriophages are considered as an alternative to antibiotics in prevention and treatment of bacterial infections, in particular cholera.The aimof the work was to demonstrate a method to obtain synthetic bacteriophage againstVibrio cholerae. Vibriophage N4 was selected as a subject for the study.Materials and methods. The genome sequence of vibriophage N4 (38.5 kb) was taken from the NCBI GenBank database. The sequence was divided into gene blocks of 1500–2000 bp. The gene blocks, in turn, were split into oligonucleotides. Sequence partitioning was carried out using the BAC-browser software that we have developed. Oligonucleotides were chemically synthesized; gene blocks were assembled from them. After that, the complete genome of vibriophage N4 was synthesized from the obtained gene blocks. The assembly of the synthetic genome took place in two stages. At the first stage, gene block cassettes of 5–7 pieces with sizes ranging from 7 to 10.5 thousand bp were generated via homologous recombination in yeast. The resulting cassettes were then amplified and used forin vitroassembly using 5’-3’ exonuclease and thermostable DNA polymerase. The resulting preparation was used for electroporation ofV. choleraecells.Results and discussion. The synthetic genome of vibriophage N4 was delivered into theV. choleraestrain M818 O1 biovar El Tor using electroporation. As a result, the formation of lytic plaques on the lawn ofV. choleraewas observed. The range of technologies we have developed: software for assembly design, enzymes and buffers for the synthesis of gene blocks and their crosslinking by homologous recombinationin vitro, the method for producing large-sized assemblies in yeast can be used to obtain artificial bacteriophages with a rational genome design.
Posterior Cruciate Ligament Injury After Retrograde Nailing of Periprosthetic Distal Femur Fractures
Authors: Martinez Frank A. , Yuan Brandon J. 
Published: April 2024

Case:
A 51-year-old man and 64-year-old woman with bilateral cruciate-retaining total knee arthroplasties (CR-TKAs) who sustained unilateral periprosthetic distal femur fractures above their CR-TKA and experienced knee instability secondary to an iatrogenic posterior-cruciate-ligament (posterior cruciate ligament [PCL]) injury from retrograde intramedullary nailing. Both patients recovered knee stability after undergoing revision surgery.

Conclusion:
Many CR-TKA designs have sufficient medial-lateral intercondylar distance to place a retrograde nail, femoral components with a relatively posterior transition from the trochlear groove to the intercondylar box will necessitate a nail starting point closer to the PCL origin. This may contribute to iatrogenic postoperative knee instability for patients with CR-TKA designs.
A Sealability Study on Bismuth-Tin Alloys for Plugging and Abandonment of Wells
Authors: Hmadeh Lewaa , Manataki Andriani , Jaculli Marcelo Anunciação , Elahifar Behzad , Sangesland Sigbjørn 
Published: April 2024

Summary
The use of bismuth alloys as a barrier material for plugging and abandonment (P&A) has gained traction in the literature due to the large number of wells scheduled to be plugged and abandoned. In addition, many questions have been raised regarding the sealing efficiency of cement in the long run. Within this context, this work performs a thorough study of the sealability of plugs made with the eutectic bismuth-tin alloy. This effort is divided into three fronts: laboratory tests to verify the pressure resistance and leakage rate of these plugs, microscopy analyses to corroborate the tests’ insights through observations of the alloy microstructure, and numerical simulations to capture and model the involved phenomena aiming to reproduce real well scenarios in the future. Results show that bismuth-tin plugs exhibit better pressure resistance and lesser leakage rates than cement plugs, which indicates that this material is a suitable candidate. Better sealing properties are achieved when the plugs are set under higher curing pressures than the atmospheric pressure, an observation that is confirmed when observing the microstructures formed. Finally, a suitable material model that captures the expansion upon solidification is proposed, and the effect of thermal expansion on the plug and pipe assembly is observed.
A New Generalized Truncated K–series Fractional Derivative
Authors: LEMNAOUAR Mohamed Reda , LOUARTASSI Younes , ZINE Rabie , Sousa J. Vanterler da C. 
Published: April 2024

Abstract
This paper proposes a new fractional derivative denoted by K–Fractional Truncated Derivative (K–FTD). K–FTD generalizes several existing fractional derivatives found in the literature including the conformable derivative, the truncated alternating derivative, the truncated M-fractional derivative, and the truncated M- series fractional derivative. Furthermore, it also satisfies the same properties of ordinary derivatives, such as linearity, product rule, and chain rule. In this respect, some classical results of the ordinary derivative such as Rolle’s theorem and the mean value theorem are extended. Then, the K–fractional integral is introduced, and the truncated K–fractional derivative, as well as the fractional integral of some orders α ∈ (n; n + 1], are defined. Finally, analytical solutions have been obtained for some differential and partial differential equations of fractional order α ∈ (0; 1] to demonstrate the described approach.
Laparoscopic and Endoscopic cooperative surgery as Rescue-treatment for Advanced gastric Cancer in patients Unfit for Surgery (LE-RACUS): protocol for a phase 1 clinical study
Authors: Maltzman Henrik , Omae Masami , Klevebro Fredrik , Baldaque-Silva Francisco , Rouvelas Ioannis 
Published: April 2024

Abstract

Background
The standard treatment for advanced gastric cancer without metastasis is gastrectomy in combination with chemotherapy. Some patients cannot tolerate such treatment because of old age or comorbidities. In this study, we want to test the feasibility of Laparoscopic and Endoscopic Cooperative Surgery (LECS) as a less invasive treatment option. In LECS, the tumor margin is marked endoscopically followed by surgical removal under endoscopic guidance. Currently, LECS is primarily used in Asian countries as a treatment for gastrointestinal stromal cell tumors.
Methods
The study will be conducted as a prospective single-center, phase 1 trial. The primary objective will be the safety of LECS, defined as Clavien-Dindo score ≥ III. The secondary objectives will be any complications, postoperative bleeding/perforation, operation time, radicality, mortality, hospital stay, and health-related quality of life.
The inclusion criteria will be patients with gastric cancer cT2-T4aN0M0, Borrman type 1-2 < 5 cm, or type 3 < 2 cm that the tumor board assesses as not fit for gastrectomy. Exclusion criteria will be Borrman type 4 and lesions in the cardia. The patients will be followed up with an outpatient appointment 30 days after the procedure.
Discussion
LECS is a promising treatment option for patients with gastric cancer who cannot tolerate gastrectomy. Compared to gastrectomy, LECS is a less invasive procedure with a documented low complication rate. No previous prospective studies have been conducted to evaluate LECS for advanced gastric cancer.
Trial registration
ClinicalTrials.gov identifier: NCT06105515. Registered 23 October 2023
https://clinicaltrials.gov/study/NCT06105515?cond=Gastric%20Cancer&term=NCT06105515&aggFilters=status:not%20rec&rank=1
Artificial neural network-based automatic detection of food intake via heart rate variability signal
Authors: Ali M. Khawar , Zhou Tong , Guo Lei , Lin Qi , Chen Jiande DZ 
Published: April 2024

Abstract

Intestinal electrical stimulation (IES) and vagus nerve stimulation have been proposed for the treatment of obesity and diabetes. The treatment can be improved if the stimulations are applied immediately after the food intake. The purpose of this study was to develop and enhance the automated food intake detection system using dynamic analysis of heart rate variability via artificial neural network (ANN). The ECG signal was recorded from 34 healthy subjects for 20 min each during following four events: sitting silently, reading, watching emotional movie, intaking food. The HRV parameters were generated from the recorded ECG signal and used to train and test as well as to optimize the ANN for the detection of food intake event. The results of Leave One Subject Out-Leave One Out (LOSO-LOO) with linear, tanh and ReLU were compared in the first step. The best ANN was tested for optimization by removing the input HRV parameters with mutual information score of less than 0.01 and with a decreased number of neurons in the hidden layer. LOSO-LOO, Leave One Subject Out (LOSO), Support Vector Machine (SVM) and Random Forest (RF) algorithms were also compared to identify the best ANN for automatic detection of food intake. The results indicated that (i) tanh algorithm outperformed both the linear and ReLU algorithms. (ii) Removing the input features with low mutual information score (<0.01) increased the performance of the ANN. (iii) The performance of ANN improved further by decreasing the number of neurons in the hidden layer from 10 to 8. (iv) LOSO outperformed both SVM and RF methods. However, LOSO-LOO was even better than LOSO in terms of sensitivity. In conclusion, the ANN using LOSO-LOO with 8 neurons in the hidden layer and 11 HRV features can be used to effectively detect food intake and may be used in a real-time IES system for treating obesity and diabetes.
Quantum Geometry in Hexagonal Circuit QED Lattice with Triple-leg Stripline Resonators
Authors: Moon Kyungsun , Kim Dongmin , Rhim Jun-Won 
Published: April 2024

Abstract
In this study, we investigate various geometric aspects of a photonic hexagonal lattice made of triple-leg stripline resonators (TSRs) in a circuit QED system.
The inherent two-fold degenerate spatial modes of the TSR act as two distinct orbitals in our 2D lattice system.
Remarkably the energy spectra of the system exhibits the dispersive quadratic band-touching to the top and bottom flat bands.
Our analysis reveals how the system harnesses destructive interference to establish flat bands via stabilized compact localized states (CLSs).
We further explore the real-space topology corresponding to the flat bands by finding proper non-contractible loop states (NLSs).
Additionally, in a zigzag-structured hexagonal lattice, we demonstrate the induction of topological flat edge modes at zero energy by analyzing the Zak phase.
We also elucidate the quantum geometric origin of other dispersive edge bands that arise from the singular point of the flat band.
Assessment of the impact of the Three Gorges Project on the ecosystem service value
Authors: LIU QIANXI , Liu Di , Zhang Conglin 
Published: April 2024

Abstract

The investigation into the impact of the Three Gorges Project on ecosystem services is crucial for ecological conservation, sustainable developmen and ecological management decisions. While numerous studies have focused on assessing the current state of regional ecosystem services, there remains a gap in research related to simulating the spatiotemporal changes and impact pathways. The objective of this paper is to uncover the direct and indirect impact pathways of ecosystem service value (ESV) in the reservoir area altered by the construction of the Three Gorges Dam project, by using the structural equation model (SEM) method. Additionally, this study aims to identify spatial and temporal changes in ecosystem service relationships over the 30 years before and after the dam's construction, utilizing self-organizing maps (SOM). The results of the study reveal that land use and land cover (LULC) factors predominantly exert direct negative effects on ESV. In comparison, socioeconomic development (ECO) and meteorological development (MET) factors have a nuanced impact on ESV, with MET factors exhibiting the strongest positive effect on ESV through the pathway MET → LULC → ESV. Furthermore, the application of SOM indicates that between 1990 and 2020, the patterns of ecosystem service bundles were spatially heterogeneous. Additionally, trade-offs and synergies between ecosystem service bundles are relevant to hydrological regulation services. These findings contribute to a comprehensive understanding of how various factors interact and influence ESV through multiple pathways. The intricate relationships among ecosystem services highlighted in the study are valuable for guiding ecological management at various scales.
Kallistatin enhances the phagocytic function of macrophages by decreasing the expression of CD24 in gastric cancer cells via the HIF-1α signaling pathway
Authors: Huang Wei , Qu Gaowen , Liang Min , Xiao Yao , Jiang Zhaojun , Lin Mingzhen , Deng Zihao , Li Weiyi , Qiu Yezhenghong , Yao Wenxia , Yu Guifang , Zhou Xinke , Ma Caiqi 
Published: April 2024

Abstract
Gastric cancer, the most frequently diagnosed type of primary cancers, is associated with a high mortality rate, and imposes a significant burden on patients and society. Recent studies have found that the kallikrein-binding protein kallistatin (KS) is involved in cancer progression. However, the effects of KS on macrophages in the immune microenvironment of gastric cancer remains elusive. In the present study, we found that overexpression of KS could enhance macrophages to engulf gastric cells in vitro. We also identified that, through immunohistochemical analysis, there was an increase in CD24 expression in gastric cancer, which was associated with unfavorable prognoses. Next, it was revealed that KS overexpression could downregulate the expression of CD24 by Sanger sequencing. In vitro experiments revealed that KS overexpression resulted in the inhibition of the hypoxia-inducible factor (HIF)-1α signaling pathway, as well as decreased expression of CD24. HIF-1α downregulation also decreased the transcription and expression of CD24 in vitro, with a magnitude similar to that seen upon KS overexpression. Furthermore, activation of AKT-HIF-1α reversed the inhibitory effect of KS overexpression, restoring the transcription and expression of CD24. Collectively, KS decreases CD24 expression via the AKT-HIF-1α pathway, altering the anti-phagocytic pattern of gastric cancer cells towards tumor-associated macrophages and strengthening innate immunity, thereby influencing the prognosis of gastric cancer. In summary, our findings have identified KS as a novel factor in the pathway that reduces CD24 expression, thus contributing to a deeper understanding of the mechanisms involved in tumor immune evasion and supplying a potential drug for gastric cancer immunotherapy.