bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extending the chemical reach of the H3 survey: detailed abundances of the dwarf-galaxy stellar stream Wukong/LMS-1
Authors: Limberg Guilherme , Ji Alexander P , Naidu Rohan P , Chiti Anirudh , Rossi Silvia , Usman Sam A , Ting Yuan-Sen , Zaritsky Dennis , Bonaca Ana , Borbolato Lais , Speagle Joshua S , Chandra Vedant , Conroy Charlie 
Published: April 2024

ABSTRACT
We present the first detailed chemical-abundance analysis of stars from the dwarf-galaxy stellar stream Wukong/LMS-1 covering a wide metallicity range ($-3.5 \lt \rm [Fe/H] \lesssim -1.3$). We find abundance patterns that are effectively indistinguishable from the bulk of Indus and Jhelum, a pair of smaller stellar streams proposed to be dynamically associated with Wukong/LMS-1. We confirmed a carbon-enhanced metal-poor star ($\rm [C/Fe] \gt +0.7$ and $\rm [Fe/H] \sim -2.9$) in Wukong/LMS-1 with strong enhancements in Sr, Y, and Zr, which is peculiar given its solar-level [Ba/Fe]. Wukong/LMS-1 stars have high abundances of α elements up to $\rm [Fe/H] \gtrsim -2$, which is expected for relatively massive dwarfs. Towards the high-metallicity end, Wukong/LMS-1 becomes α-poor, revealing that it probably experienced fairly standard chemical evolution. We identified a pair of N- and Na-rich stars in Wukong/LMS-1, reminiscent of multiple stellar populations in globular clusters. This indicates that this dwarf galaxy contained at least one globular cluster that was completely disrupted in addition to two intact ones previously known to be associated with Wukong/LMS-1, which is possibly connected to similar evidence found in Indus. From these ≥3 globular clusters, we estimate the total mass of Wukong/LMS-1 to be ${\approx }10^{10} \, \mathrm{M}_\odot$, representing ∼1 per cent of the present-day Milky Way. Finally, the [Eu/Mg] ratio in Wukong/LMS-1 continuously increases with metallicity, making this the first example of a dwarf galaxy where the production of r-process elements is clearly dominated by delayed sources, presumably neutron-star mergers.
The persistence of high altitude non-equilibrium diffuse ionized gas in simulations of star-forming galaxies
Authors: McCallum Lewis , Wood Kenneth , Benjamin Robert , Peñaloza Camilo , Krishnarao Dhanesh , Smith Rowan , Vandenbroucke Bert 
Published: April 2024

ABSTRACT
Widespread, high altitude, diffuse ionized gas with scale heights of around a kiloparsec is observed in the Milky Way and other star-forming galaxies. Numerical radiation-magnetohydrodynamic simulations of a supernova-driven turbulent interstellar medium show that gas can be driven to high altitudes above the galactic mid-plane, but the degree of ionization is often less than inferred from observations. For computational expediency, ionizing radiation from massive stars is often included as a post-processing step assuming ionization equilibrium. We extend our simulations of an Milky Way-like interstellar medium to include the combined effect of supernovae and photoionization feedback from mid-plane OB stars and a population of hot evolved low mass stars. The diffuse ionized gas has densities below 0.1 ${\rm \,cm^{-3}}$, so recombination time-scales can exceed millions of years. Our simulations now follow the time-dependent ionization and recombination of low density gas. The long recombination time-scales result in diffuse ionized gas that persists at large altitudes long after the deaths of massive stars that produce the vast majority of the ionized gas. The diffuse ionized gas does not exhibit the large variability inherent in simulations that adopt ionization equilibrium. The vertical distribution of neutral and ionized gas is close to what is observed in the Milky Way. The volume filling factor of ionized gas increases with altitude resulting in the scale height of free electrons being larger than that inferred from H $\alpha$ emission, thus reconciling the observations of ionized gas made in H $\alpha$ and from pulsar dispersion measurements.
Development of anti-MDA5 autoantibody-positive dermatomyositis following the use of etanercept biosimilar in rheumatoid arthritis
Authors: Okazaki Soshi , Shirai Tsuyoshi , Sato Hiroko , Ishii Tomonori , Fujii Hiroshi 
Published: April 2024

ABSTRACT
The induction of autoimmune diseases during tumour necrosis factor-alpha inhibitor (TNFi) usage has been described. Herein, we report a rare case of a 49-year-old woman with antimelanoma differentiation-associated gene 5 (MDA5) antibody (Ab)-positive dermatomyositis (DM), which developed 5 weeks after the introduction of an etanercept biosimilar to rheumatoid arthritis (RA). Four of the five known cases, including ours, of anti-MDA5Ab-positive DM complicated with RA revealed anti-MDA5Ab-positive DM following TNFi usage. When patients with RA are diagnosed with interstitial lung disease during TNFi usage, anti-MDA5 Ab-positive DM could be a differential diagnosis.
Successful treatment of erythema nodosum with salazosulfapyridine in a 9-year-old patient with chronic non-bacterial osteomyelitis
Authors: Shimomura Masaki , Okura Yuka , Takahashi Yutaka , Kobayashi Ichiro 
Published: April 2024

ABSTRACT
We report a 9-year-old Japanese girl with chronic non-bacterial osteomyelitis (CNO) accompanied by recurrent erythema nodosum (EN) which was successfully treated with salazosulfapyridine (SASP). She was referred to our hospital because of recurrent erythema on her lower extremities and persistent knee and ankle arthralgia, which had been present for approximately 1 year. Although naproxen, a nonsteroidal anti-inflammatory drug, was initiated, her symptoms frequently recurred. Magnetic resonance imaging demonstrated multiple distinct high-intensity signals in the talus bones suggestive of multiple bone oedemas. Additionally, a histological examination of erythematous lesions was consistent with the histopathological findings of EN. She was diagnosed as having CNO complicated by EN, and received 250 mg/day of SASP as a second-line treatment, which showed partial response of both skin and bone lesions. Following increase in the dose of SASP to 500 mg/day resulted in complete remission of her skin and bone lesions. In conclusion, our findings suggest that SASP is effective not only for CNO bone lesions but also for EN. SASP could serve as a second-line therapeutic option at least for some cases of CNO complicated by EN refractory to nonsteroidal anti-inflammatory drugs.
KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons
Authors: Yheskel Matanel , Hatch Hayden A M , Pedrosa Erika , Terry Bethany K , Siebels Aubrey A , Zheng Xiang Yu , Blok Laura E R , Fencková Michaela , Sidoli Simone , Schenck Annette , Zheng Deyou , Lachman Herbert M , Secombe Julie 
Published: April 2024

Abstract
Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals with intellectual disability (ID). To understand the link between KDM5 and ID, we characterized five Drosophila strains harboring missense alleles analogous to those observed in patients. These alleles disrupted neuroanatomical development, cognition and other behaviors, and displayed a transcriptional signature characterized by the downregulation of many ribosomal protein genes. A similar transcriptional profile was observed in KDM5C knockout iPSC-induced human glutamatergic neurons, suggesting an evolutionarily conserved role for KDM5 proteins in regulating this class of gene. In Drosophila, reducing KDM5 changed neuronal ribosome composition, lowered the translation efficiency of mRNAs required for mitochondrial function, and altered mitochondrial metabolism. These data highlight the cellular consequences of altered KDM5-regulated transcriptional programs that could contribute to cognitive and behavioral phenotypes. Moreover, they suggest that KDM5 may be part of a broader network of proteins that influence cognition by regulating protein synthesis.
Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation
Authors: Matsuzaki Kenichiro , Shinohara Akira , Shinohara Miki 
Published: April 2024

Abstract
RAD51 filament is crucial for the homology-dependent repair of DNA double-strand breaks and stalled DNA replication fork protection. Positive and negative regulators control RAD51 filament assembly and disassembly. RAD51 is vital for genome integrity but excessive accumulation of RAD51 on chromatin causes genome instability and growth defects. However, the detailed mechanism underlying RAD51 disassembly by negative regulators and the physiological consequence of abnormal RAD51 persistence remain largely unknown. Here, we report the role of the human AAA+ ATPase FIGNL1 in suppressing a novel type of RAD51-mediated genome instability. FIGNL1 knockout human cells were defective in RAD51 dissociation after replication fork restart and accumulated ultra-fine chromosome bridges (UFBs), whose formation depends on RAD51 rather than replication fork stalling. FIGNL1 suppresses homologous recombination intermediate-like UFBs generated between sister chromatids at genomic loci with repeated sequences such as telomeres and centromeres. These data suggest that RAD51 persistence per se induces the formation of unresolved linkage between sister chromatids resulting in catastrophic genome instability. FIGNL1 facilitates post-replicative disassembly of RAD51 filament to suppress abnormal recombination intermediates and UFBs. These findings implicate FIGNL1 as a key factor required for active RAD51 removal after processing of stalled replication forks, which is essential to maintain genome stability.
”It’s changed my life. I’m not smoking anymore. I don’t want to smoke anymore”: Exploring the Acceptability of Mailout Smoking Cessation Support for and by Aboriginal and Torres Strait Islander People
Authors: Booth Kade , Roberts-Barker (Wiradjuri) Kayden , Foster (Worimi) Joley , Mersha Amanual Getnet , Maddox (Bagumani) Raglan , Bonevski Billie , Chamberlain (Palawa) Catherine , Clarke (Worimi/Gamilaroi) Kerindy , Segan Catherine , Kennedy (Wiradjuri) Michelle 
Published: April 2024

Abstract

Introduction
Aboriginal and Torres Strait Islander people want to quit smoking. There is global evidence of combination nicotine replacement therapy (c-NRT) alongside behavioral support as a best practice approach to smoking cessation care. However, there is limited adherence and acceptability research regarding NRT and behavioral supports for Aboriginal and Torres Strait Islander people. Similarly, there is limited research on what is considered culturally appropriate and safe support for Aboriginal and Torres Strait Islander people to quit smoking.

Aims and Methods
This Aboriginal-led qualitative study explored the acceptability of the Koori Quit Pack. Aboriginal and Torres Strait Islander participants shared their experiences of quitting with the mailout c-NRT program and behavioral cessation support through Yarning. Collaborative Yarning and reflexive thematic analysis was used to develop themes.

Results
Aboriginal and Torres Strait Islander people are motivated to quit smoking and have accessed cessation supports from health professionals. However, the support(s) received are not always appropriate or culturally safe. The Koori Quit Pack was deemed acceptable and useful for smoking cessation. Having access to smoking cessation care and knowledge of c-NRT helped people quit smoking and support others to quit too.

Conclusions
A combination of NRT products alongside culturally responsive behavioral support(s), delivered through a mailout package was a beneficial strategy to help Aboriginal and Torres Strait Islander people quit smoking. National implementation of such a package could assist to accelerate reductions in tobacco use, helping meet national smoking reduction targets and improve health outcomes.

Implications
Cessation supports offered to Aboriginal and Torres Strait Islander people are not always culturally safe or effectively delivered. The Koori Quit Pack provided Aboriginal and Torres Strait Islander people with culturally safe smoking cessation support delivered for and by Aboriginal and Torres Strait Islander people, demonstrating mailout smoking cessation supports as acceptable and highly valued. Mailout support eliminates accessibility barriers to cessation care while providing tools and knowledge to quit can lead to smoke-free behaviors among individuals and communities. Country-wide availability of this program can accelerate reductions in tobacco use, helping meet national targets and improve health outcomes consistent with the National Tobacco Strategy and the WHO Framework Convention on Tobacco Control.
A process to reanalyze clinical DNA sequencing data for biomarker matching in the Lung-MAP Master Protocol
Authors: Neal Joel W , Minichiello Katherine , Brennick Ryan , Huang Richard S P , Hiemenz Matthew C , Amler Cornel , Patel Jyoti , Herbst Roy , Reckamp Karen L , Borghaei Hossein , Highleyman Louise , Redman Mary W , Pasquina Lincoln W , Kozono David E 
Published: April 2024

Abstract
For cancer clinical trials that require central confirmation of tumor genomic profiling, exhaustion of tissue from standard-of-care testing may prevent enrollment. For Lung-MAP, a master protocol that requires results from a defined centralized clinical trial assay to assign patients to a therapeutic substudy, we developed a process to repurpose existing commercial vendor raw genomic data for eligibility: genomic data reanalysis (GDR). Molecular results for substudy assignment were successfully generated for 369 of the first 374 patients (98.7%) using GDR for Lung-MAP, with a median time from request to result of 9 days. During the same period, 691 of 791 (87.4%) tissue samples received successfully yielded results, in a median of 14 days beyond sample acquisition. GDR is a scalable bioinformatic pipeline that expedites reanalysis of existing data for clinical trials in which validated integral biomarker testing is required for participation.
The Chaperone NASP Contributes to de Novo Deposition of the Centromeric Histone Variant CENH3 in Arabidopsis Early Embryogenesis
Authors: Takeuchi Hidenori , Nagahara Shiori , Higashiyama Tetsuya , Berger Frédéric 
Published: April 2024

Abstract
The centromere is an essential chromosome region where the kinetochore is formed to control equal chromosome distribution during cell division. The centromere-specific histone H3 variant CENH3 (also called CENP-A) is a prerequisite for the kinetochore formation. Since CENH3 evolves rapidly, associated factors, including histone chaperones mediating the deposition of CENH3 on the centromere, are thought to act through species-specific amino acid sequences. The functions and interaction networks of CENH3 and histone chaperons have been well-characterized in animals and yeasts. However, molecular mechanisms involved in recognition and deposition of CENH3 are still unclear in plants. Here, we used a swapping strategy between domains of CENH3 of Arabidopsis thaliana and the liverwort Marchantia polymorpha to identify specific regions of CENH3 involved in targeting the centromeres and interacting with the general histone H3 chaperone, nuclear autoantigenic sperm protein (NASP). CENH3’s LoopN-α1 region was necessary and sufficient for the centromere targeting in cooperation with the α2 region and was involved in interaction with NASP in cooperation with αN, suggesting a species-specific CENH3 recognition. In addition, by generating an Arabidopsis nasp knock-out mutant in the background of a fully fertile GFP-CENH3/cenh3-1 line, we found that NASP was implicated for de novo CENH3 deposition after fertilization and thus for early embryo development. Our results imply that the NASP mediates the supply of CENH3 in the context of the rapidly evolving centromere identity in land plants.
Environmental Sensitivity Scale for Social Workers: A Scale Development Study
Authors: Yanardağ Umut , Çay Murat , Zubaroğlu Yanardağ Melek 
Published: April 2024

Abstract
The objective of this quantitative study was to develop a valid and reliable scale to examine the environmental sensitivity of social workers, the Environmental Sensitivity Scale. First, the researchers created an item pool by considering the information in the literature. Then, exploratory factor analysis (EFA), confirmatory factor analysis and reliability analyses were carried out. A total of 314 social workers practicing in the field in Türkiye (previosly referred to as Turkey) participated in the study. The EFA conducted for validity indicated an 11-item structure composed of two factors. The first factor provides information about environmental sensitivity in macro practices ; the second factor provides information about environmental sensitivity in micro and mezzo practices. The reliability analyses also revealed that the resulting structure was reliable. The Cronbach’s alpha reliability coefficients for the first factor, second factor, and total score were .830, .815, and .875, respectively. The developed scale can be utilized to figure out the attitudes of social workers about environmental sensitivity.
Civil Procedure Takes a Bold Step: Unravelling the changes to service out of the jurisdiction and the Civil Procedure Rules in the British Virgin Islands
Authors: Edwards Paul 
Published: April 2024

Abstract
Following years of consultation, the ECSC Civil Procedure Rules 2000 gave way to the revamped and refreshed ECSC Civil Procedure Rules, Revised Edition 2023 (Civil Procedure Rules, Revised 2023), which came into effect on 31 July 2023. The Civil Procedure Rules, Revised 2023, brought sweeping and significant changes to civil practice and procedure, particularly in the areas of service out of the jurisdiction, relief from sanctions, and costs. The Civil Procedure Rules, Revised 2023, gave birth to a novel alternative dispute resolution mechanism, the Judicial Settlement Conference, intended to complement the well-established out-of-court arrangement of court-ordered mediations.
The Power and Roots of Aspirations
Authors: Fruttero Anna , Muller Noël , Calvo-González Óscar 
Published: April 2024

Abstract
Aspirations have become a common theme in empirical economics studies but there is no unified understanding of the range of outcomes they influence, the factors that shape them, and how to measure them. We survey this growing literature. We argue that there is compelling evidence to consider aspirations as a useful lens to analyze human behavior and development outcomes, at the individual and aggregate levels, in poorer and richer countries. The empirical evidence aligns with the theory that high aspirations can lead individuals to achieve better educational, labor market, and other outcomes and can contribute to making countries more equal and prosperous. The empirical evidence also confirms that the mix of social and circumstantial factors shaping aspirations tends to hinder the aspirations of the disadvantaged—such as the poor, immigrants, and women—and can contribute to vicious circles of poverty, high inequality, low social mobility, and low growth. However, high aspirations should not be considered an end in themselves as they can backfire, with deleterious effects, if unmatched with opportunities. Further, we argue that definitional and measurement issues can affect the understanding of the topic and that studies should more explicitly describe their measures of aspirations to ensure that divergent underlying concepts are not mistaken.
Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta‐analysis
Authors: Ringleb Miriam , Javelle Florian , Haunhorst Simon , Bloch Wilhelm , Fennen Lena , Baumgart Sabine , Drube Sebastian , Reuken Philipp A. , Pletz Mathias W. , Wagner Heiko , Gabriel Holger H. W. , Puta Christian 
Published: April 2024

AbstractMyokines, released from the muscle, enable communication between the working muscles and other tissues. Their release during physical exercise is assumed to depend on immune–hormonal–metabolic interactions concerning mode (endurance or resistance exercise), duration, and intensity. This meta‐analysis aims to examine the acute changes of circulating myokines inducing immunoregulatory effects caused by a bout of resistance exercise and to consider potential moderators of the results. Based on this selection strategy, a systematic literature search was conducted for resistance exercise intervention studies measuring interleukin (IL‐) 6, IL‐10, IL‐1ra, tumor necrosis factor (TNF‐) α, IL‐15, IL‐7, transforming growth factor (TGF‐) β1, and fractalkines (FKN) before and immediately after resistance exercise in healthy individuals. Random‐effects meta‐analysis was performed for each myokine. We identified a moderate positive effect of resistance exercise for IL‐6 and IL‐1ra. Regarding IL‐15 and TNF‐α, small to moderate effects were found. For IL‐10, no significant effect was observed. Due to no data, meta‐analyses for IL‐7, TGF‐β1, and FKN could not be performed. No moderators (training status, type of exercise, risk of bias, age, sex, time of day, exercise volume, exercise intensity, exercise dose) of the results were detected for all tested myokines. Taken together, this systematic review and meta‐analysis showed immediate positive effects of an acute resistance exercise session on IL‐6, IL‐1ra, TNF‐α, and IL‐15 levels.
Alteration of the intestinal microbiota and serum metabolites in a mouse model of Pon1 gene ablation
Authors: Li Jing , Yan Kaixin , Wang Siyuan , Wang Pan , Jiao Jie , Dong Ying 
Published: April 2024

AbstractMutations in the Paraoxonase 1 (Pon1) gene underlie aging, cardiovascular disease, and impairments of the nervous and gastrointestinal systems and are linked to the intestinal microbiome. The potential role of Pon1 in modulating the intestinal microbiota and serum metabolites is poorly understood. The present study demonstrated that mice with genomic excision of Pon1 by a multiplexed guide RNA CRISPR/Cas9 approach exhibited disrupted gut microbiota, such as significantly depressed alpha‐diversity and distinctly separated beta diversity, accompanied by varied profiles of circulating metabolites. Furthermore, genomic knock in of Pon1 exerted a distinct effect on the intestinal microbiome and serum metabolome, including dramatically enriched Aerococcus, linoleic acid and depleted Bacillus, indolelactic acid. Specifically, a strong correlation was established between bacterial alterations and metabolites in Pon1 knockout mice. In addition, we identified metabolites related to gut bacteria in response to Pon1 knock in. Thus, the deletion of Pon1 affects the gut microbiome and functionally modifies serum metabolism, which can lead to dysbiosis, metabolic dysfunction, and infection risk. Together, these findings put forth a role for Pon1 in microbial alterations that contribute to metabolism variations. The function of Pon1 in diseases might at least partially depend on the microbiome.
Managing major depressive disorder in adolescents in primary care
Authors: Martinez Don T. 
Published: April 2024

ABSTRACT
Major depressive disorder (MDD) remains a significant risk to adolescent health and well-being, recently amplified by the COVID-19 pandemic. Access to adolescent mental health care services remains challenging in many areas, resulting in many adolescents diagnosed with MDD remaining untreated. Primary care providers are becoming increasingly crucial in promptly diagnosing and treating this concern. Various clinical guidelines can support clinicians in developing strategies for screening, diagnosing, and managing a vulnerable population with MDD. Standardized screenings, algorithms, and treatment guidelines can help improve the quality of life and functional impairment of those with MDD.