bluuebunny/crossref_metadata_2025_split huggingface dataset:
New rotational rate coefficients computation of MgC3N(X2Σ+) by collision with He(1S)
Authors: Hachani L , Khadri F , Jaïdane N , Elabidi H , Hammami K 
Published: March 2024

ABSTRACT
Determining physical conditions in interstellar environments requires reliable estimation of collisional data for molecules detected in space. In this work, we report a rate coefficients calculation of MgC3N(X2Σ+) induced by collision with He. This study is based on a new 2D potential energy surface (2D-PES), obtained from the explicitly correlated restricted open-shell coupled cluster approach with single, double, and perturbative triple excitation (rccsd(t)-f12) and the aug-cc-pVTZ basis sets. The MgC3N–He PES presents a global minimum with a well depth of −45.6 cm−1. Based on this interaction potential, we derived the excitation cross-sections using the close-coupling quantum time-independent formalism for total energies ≤500 cm−1 and N ≤ 40. These cross-sections were then integrated on a Maxwell–Boltzmann distribution of kinetic energies to obtain the collisional (de)-excitation rate coefficients for thermal temperature below 100 K. A non-LTE radiative transfer calculation was performed using the present collisional rates in order to estimate their impact on the abundance of MgC3N. These collisional data can help astronomers for the detection and an accurate determination of MgC3N abundance in the investigated interstellar clouds.
Spectral and type I X-ray burst studies of 4U 1702−429 using AstroSat observations
Authors: Varun M , Thomas Neal Titus , Gudennavar S B , Bubbly S G 
Published: March 2024

ABSTRACT
4U 1702−429, an atoll-type neutron star low-mass X-ray binary, was observed twice by the AstroSat/Soft X-ray Telescope (SXT) and Large Area X-ray Proportional Counters (LAXPC-20) on 2018 April 27 and 2019 August 8. Persistent emission spectra of the source were well fitted with the model combination - constant × tbabs (thcomp × diskbb+powerlaw). The parameters obtained from the spectral analysis revealed the source to be in a hard spectral state during the observations. Time-resolved spectral analyses were performed on the three type I X-ray bursts detected from the source. Burst analysis showed that the source underwent a photospheric radius expansion. Consequently, the radius of the neutron star and distance to the source (with isotropic and anisotropic burst emission) were obtained as 12.65$\substack{+0.90\\-0.86}$ km and 6.92$\substack{+0.16\\-0.09}$ and 8.43$\substack{+0.20\\-0.10}$ kpc, respectively.
HIF1α/ATF3 partake in PGK1 K191/K192 succinylation by modulating P4HA1/succinate signaling in glioblastoma
Authors: Yang Shixue , Zhan Qi , Su Dongyuan , Cui Xiaoteng , Zhao Jixing , Wang Qixue , Hong Biao , Ju Jiasheng , Cheng Chunchao , Yang Eryan , Kang Chunsheng 
Published: March 2024

Abstract

Background
Hypoxia is a pathological hallmark in most cancers, including glioblastoma (GBM). Hypoxic signaling activation and post-translational modification (PTM) of oncogenic proteins are well-studied in cancers. Accumulating studies indicate glycolytic enzyme PGK1 plays a crucial role in tumorigenesis, yet the underlying mechanisms remain unknown.

Methods
We first used ChIP assays to uncover the crosstalk between HIF1α and ATF3 and their roles in P4HA1 regulation. Protein degradation analysis, LC-MS/MS, and in vitro succinate production assays were performed to examine the effect of protein succinylation on GBM pathology. Seahorse assay measured the effects of PGK1 succinylation at K191/K192 or its mutants on glucose metabolism. We utilized an in vivo intracranial mouse model for biochemical studies to elucidate the impact of ATF3 and P4HA1 on aerobic glycolysis and the tumor immune microenvironment.

Results
We demonstrated that HIF1α and ATF3 positively and negatively regulate the transcription of P4HA1, respectively, leading to an increased succinate production and increased activation of HIF1α signaling. P4HA1 expression elevated the succinate concentration, resulting in the enhanced succinylation of PGK1 at the K191 and K192 sites. Inhibition of proteasomal degradation of PGK1 by succinylation significantly increased aerobic glycolysis to generate lactate. Furthermore, ATF3 overexpression and P4HA1 knockdown reduced succinate and lactate levels in GBM cells, inhibiting immune responses and tumor growth.

Conclusions
Together, our study demonstrates that HIF1α/ATF3 participated in P4HA1/succinate signaling, which is the major regulator of succinate biosynthesis and PGK1 succinylation at K191 and K192 sites in GBM. The P4HA1/succinate pathway might be a novel and promising target for aerobic glycolysis in GBM.
Evaluations of Compliance With California’s First Tobacco Sales Bans and Tobacco Marketing in Restricted and Cross-Border Stores
Authors: Henriksen Lisa , Andersen-Rodgers Elizabeth , Voelker David H , Johnson Trent O , Schleicher Nina C 
Published: March 2024

Abstract

Introduction
Beverly Hills and Manhattan Beach were the first California cities to end tobacco sales. Previous research assessed retailers’ perceptions of the laws. This study is the first to evaluate compliance (Study 1), assess whether branded or unbranded tobacco cues remain, and examine cigarette prices/discounts in cross-border stores (Study 2).

Aims and Methods
Each of the four data collectors requested Marlboro or e-cigarettes (randomly assigned) in all restricted stores (n = 33) until four attempts were exhausted or a violation occurred. Follow-up visits recorded whether former tobacco retailers advertised tobacco or contained unbranded cues. In a random sample of 126 cross-border stores (half within 1 mile of no-sales cities and half 2–4 miles away), data collectors recorded price of Marlboro and presence of cigarette discounts. Mixed models (stores within tracts), tested for differences between near and far stores, adjusting for store type and median household income.

Results
Compliance was 87.5%: three stores sold Marlboro (US $8, $10, and $10) and one sold Puff Bar (US $16). Tobacco-branded items and unbranded tobacco cues remained in one store each. Mean Marlboro price was US $10.61 (SD = 1.92) at stores within 1 mile of no-sales cities, averaging US $0.73 more than at stores farther away (p &lt; .05). However, odds of advertising cigarette discounts did not differ between stores nearby and farther from no-sales cities.

Conclusions
Nearly all retailers complied with tobacco sales bans within 6–12 months of implementation. In addition, retail tobacco marketing was nearly eliminated in the two cities. There was no evidence of price gouging for Marlboro cigarettes in cross-border stores.

Implications
Evidence from two early adopters of tobacco sales bans suggests that such local laws can be implemented effectively in California, although results from these high-income cities in a state with a strong tobacco control record limits generalizability. Enforcement involving routine purchase attempts rather than visual inspection of tobacco products is recommended. Although Beverly Hills and Manhattan Beach are each surrounded by communities where tobacco sales persist, there was no evidence of price gouging for cigarettes or greater presence of discounts in cross-border stores. Evaluations of the economic impacts and public health benefits of tobacco sales bans are much needed.
The New Racial Spillover: Donald Trump, Racial Attitudes, and Public Opinion Toward Accountability for Perpetrators and Planners of the January 6 Capitol Attack
Authors: Rhodes Jesse H , Nteta Tatishe M 
Published: March 2024

Abstract
Since the violent January 6 attack on the U.S. Capitol, federal authorities have sought to hold participants and organizers accountable for their assault on American democracy. Troublingly, however, a substantial fraction of the public opposes the prosecution of participants in the assault on the Capitol and rejects charging former president Trump with crimes relating to the planning and execution of the attack. Why does a substantial fraction of the American public oppose accountability for perpetrators of the January 6 attack? In this article, we argue that racial attitudes play a central role in determining individuals' attitudes toward accountability for the Capitol attack. Elaborating on the theory of “racial spillover,” we argue that former president Trump's frequent use of racial rhetoric—which established a racialized identity and cemented a close relationship between negative racial attitudes and support for his presidency among members of the mass public—created conditions in which these attitudes were likely to “spill over” into the ostensibly non-racialized domain of attitudes toward holding perpetrators, planners, and inciters accountable for the attack. Because attitudes toward accountability for the Capitol attack are inextricable from Trump's racialized persona, we hypothesize that negative racial attitudes should be associated with increased opposition to accountability for those responsible for the attack. Using data from four original, nationally representative surveys fielded between 2021 and 2023, we find strong evidence for our racial spillover hypothesis and show that individuals with more negative racial attitudes are more opposed to accountability for those responsible for the Capitol attack.
ITF2357 regulates NF‐κB signaling pathway to protect barrier integrity in retinal pigment epithelial cells
Authors: Lim Rayne R. , Mahaling Binapani , Tan Alison , Mehta Milan , Kaur Charanjit , Hunziker Walter , Kim Judy E. , Barathi Veluchamy A. , Ghosh Arkasubhra , Chaurasia Shyam S. 
Published: March 2024

AbstractThe robust integrity of the retinal pigment epithelium (RPE), which contributes to the outer brain retina barrier (oBRB), is compromised in several retinal degenerative and vascular disorders, including diabetic macular edema (DME). This study evaluates the role of a new generation of histone deacetylase inhibitor (HDACi), ITF2357, in regulating outer blood‐retinal barrier function and investigates the underlying mechanism of action in inhibiting TNFα‐induced damage to RPE integrity. Using the immortalized RPE cell line (ARPE‐19), ITF2357 was found to be non‐toxic between 50 nM and 5 μM concentrations. When applied as a pre‐treatment in conjunction with an inflammatory cytokine, TNFα, the HDACi was safe and effective in preventing epithelial permeability by fortifying tight junction (ZO‐1, ‐2, ‐3, occludin, claudin‐1, ‐2, ‐3, ‐5, ‐19) and adherens junction (E‐cadherin, Nectin‐1) protein expression post‐TNFα stress. Mechanistically, ITF2357 depicted a late action at 24 h via attenuating IKK, IκBα, and p65 phosphorylation and ameliorated the expression of IL‐1β, IL‐6, and MCP‐1. Also, ITF2357 delayed IκBα synthesis and turnover. The use of Bay 11‐7082 and MG132 further uncovered a possible role for ITF2357 in non‐canonical NF‐κB activation. Overall, this study revealed the protection effects of ITF2357 by regulating the turnover of tight and adherens junction proteins and modulating NF‐κB signaling pathway in the presence of an inflammatory stressor, making it a potential therapeutic application for retinal vascular diseases such as DME with compromised outer blood‐retinal barrier.
A meta-analysis on the risk of infection associated with intravenous iron therapy in cancer-associated anaemia: a double-edged sword?
Authors: Meyers Michel , Salmon Maurine , Libert Isabelle , Klášterský Jean 
Published: March 2024

Purpose of review
The increased use of i.v. iron in the treatment of cancer-associated anemia raises concerns about its risk of infectious complications. High levels of circulating iron could increase the risk of infection by compromising natural defence mechanisms and promoting pathogen growth. Since the risk of infection is particularly high in the oncological population, we have examined whether the use of i.v. iron increases the risk of infectious complications among cancer patients.

Findings
Among 18 randomized trials in our systematic review, only 8 reported infectious complications, with no significant difference linked to the type of i.v. iron preparation. Two trials showed a statistically significant increase in infectious complications, one trial found a lower risk, while the remaining 5 reported no significant difference. Our meta-analysis revealed a numerical increase in infectious complications in the i.v. iron group, but the lack of statistical significance and significant heterogeneity among the trials limit definitive conclusions on the actual infection risk.

Summary
Our findings suggest some increased risk in infectious complications after the administration of i.v. iron for cancer associated anaemia. However, i.v. iron therapy appears generally safe and effective in cancer-associated anaemia.
Current outstanding challenges in germ cell tumors
Authors: Salous Tareq , Adra Nabil 
Published: March 2024

Purpose of review
Despite the remarkable advances in the treatment of germ cell tumors (GCT), several challenges remain. This review aims to highlight some of these challenges and provide guidance on how to navigate through them.

Recent findings
Patients with International Germ Cell Cancer Collaborative Group poor risk disease have worse prognosis and investigating novel therapeutic interventions are warranted in this population. Patients with brain metastases require a multidisciplinary approach by a group of clinicians experienced in the management of germ cell tumors. Patients with platinum refractory disease have poor prognosis and development of novel treatment options is urgently needed. Conventional tumor markers including alpha fetoprotein and human chorionic gonadotropin remain standard. Development of novel biomarkers to detect minimal residual disease or teratoma is needed.

Summary
Management of patients with GCT requires a multidisciplinary approach. Patients should preferably be evaluated at tertiary care centers with expertise in the management of this disease.
Supportive cancer care: is integrative oncology the future?
Authors: Theunissen Ingrid , Bagot Jean-Lionel 
Published: March 2024

Purpose of review
Nearly half of cancer patients use complementary therapies alongside the conventional cancer treatment. This clinical reality is a challenge for the medical team mainly to guarantee patient's safety. The evolution from Supportive Care to Integrative oncology is taking shape.

Recent findings
Integrative oncology, a new field in cancer care, combines conventional supportive care and validated complementary approaches. The first part of this review is to highlight the process of validation of one of the most popular complementary medicines among European cancer patients: homeopathy. It seems to be a well tolerated and useful complementary approach in integrative cancer care. The second part shows through the example of stage IV lung cancer the transition from conventional supportive care to integrative oncology with a benefit for their quality of life and survival.

Summary
The future of supportive cancer care seems to lead towards a move from coexistence of conventional care and complementary approaches to a combination of both in integrative oncology. This would require new skills among caregivers, specific academic training and adapted studies. Further research is needed to highlight the benefits in the specific field of integrative cancer care.
Development and Evaluation of a Promising Biomarker for Diagnosis of Latent and Active Tuberculosis Infection
Authors: Peng Cong , Jiang Fan , Liu Yinping , Xue Yong , Cheng Peng , Wang Jie , Wang Liang , Gong Wenping 
Published: March 2024

Abstract

Background
Diagnosing latent tuberculosis (TB) infection (LTBI) and active TB (ATB) is crucial for preventing disease progression and transmission. However, current diagnostic tests have limitations in terms of accuracy and sensitivity, making it challenging to diagnose these different infection states. Therefore, this study intends to develop a promising biomarker for LTBI and ATB diagnosis to overcome the limitations of the current diagnostic tests.

Methods
We developed a novel multiepitope-based diagnostic biomarker (MEBDB) from LTBI region of differentiation antigens using bioinformatics and immunoinformatics. Immune responses induced by MEBDM were detected using enzyme-linked immunosorbent spot and cytometric bead assays. This study was conducted from April 2022 to December 2022 in the Senior Department of Tuberculosis at the 8th Medical Center of PLA General Hospital, China. Blood samples were collected from participants with ATB, individuals with LTBI, and healthy controls (HCs). The diagnostic efficacy of MEBDB was evaluated using receiver operating characteristic curves.

Results
A novel MEBDB, designated as CP19128P, was generated. CP19128P comprises 19 helper T lymphocyte epitopes, 12 cytotoxic T lymphocyte epitopes, and 8 B-cell epitopes. In silico simulations demonstrated that CP19128P possesses strong affinity for Toll-like receptors and elicits robust innate and adaptive immune responses. CP19128P generated significantly higher levels of tumor necrosis factor (TNF-α), interleukin 4 (IL-4), and IL-10 in ATB patients (n = 7) and LTBI (n = 8) individuals compared with HCs (n = 62) (P < 0.001). Moreover, CP19128P-induced specific cytokines could be used to discriminate LTBI and ATB from healthy subjects with high sensitivity and specificity. Combining IL-2 with IL-4 or TNF-α could differentiate LTBI from HCs (the area under the receiver operating characteristic curve [AUC], 0.976 [95% confidence interval [CI], 0.934–1.000] or 0.986 [0.956–1.000]), whereas combining IL-4 with IL-17A or TNF-α could differentiate ATB from HCs (AUC, 0.887 [0.782–0.993] or 0.984 [0.958–1.000]).

Conclusions
Our study revealed that CP19128P is a potential MEBDB for the diagnosis of LTBI and ATB. Our findings suggest a promising strategy for developing novel, accurate, and sensitive diagnostic biomarkers and identifying new targets for TB diagnosis and management.
Cytomegalovirus Transverse Myelitis Secondary to Influenza Infection and Early Recovery: A Case Report
Authors: Bhavsar Jill S. , Fultariya Lekhini K. , Prajapati Poojan J. , Dhamelia Archi K. , Campos Jaime E. 
Published: March 2024

Abstract
Immunosuppression can lead to opportunistic infections in a host. The evidence of viral infections causing immunosuppression in a host for a transient period is gaining attention. In order to prolong their stay in the human body, viruses affect the human immune system in various ways. Common viral infections such as influenza can lead to transient lymphocytopenia, which lays the groundwork for more dangerous opportunistic infections. Cytomegalovirus (CMV) infection is a rare cause of inflammatory myelopathy. We present the case of a patient with an influenza infection who progressed to severe acute respiratory distress syndrome, methicillin-resistant Staphylococcus aureus necrotizing pneumonia, and idiopathic lymphocytopenia with a CD4 count of 61 per μL on arrival. After 2 weeks, the patient developed complete flaccid paralysis with sensory and autonomic dysfunction. Because his polymerase chain reaction results of cerebrospinal fluid and blood test were positive for CMV infection, he was treated with high doses of steroids and ganciclovir intravenously. Due to early diagnosis and intervention, the patient was able to recover in 2 months with only minimal residual weakness. Thus, this case stresses on the importance of looking out for opportunistic infections in patients affected by severe viral infections for their early recovery.
Scalp acupuncture for post-stroke spastic hemiparesis: A systematic review and meta-analysis
Authors: Zhang Dongxue , Zou Wei , Zhang Baiwen , Guo Peixin 
Published: March 2024

Background:
Spastic paralysis is one of the most common sequelae of stroke, severely affecting patients’ limb function and reducing their quality of life. Scalp acupuncture (SA) has been shown to significantly improve cerebral blood supply and reduce the severity of limb spasticity. This meta-analysis aims to systematically evaluate the clinical efficacy of SA in the treatment of post-stroke spastic paralysis, providing evidence-based medicine for clinical management of this condition.

Methods:
We comprehensively searched databases including China National Knowledge Infrastructure, Wanfang Data, VIP Chinese Science and Technology Periodical Database, China Biomedical Literature Database, PubMed, Embase, and Cochrane Library. Randomized controlled trials investigating the efficacy of SA in post-stroke spastic paralysis were identified until July 28, 2023. Meta-analysis was conducted using RevMan 5.4 and Stata17.0.

Results:
A total of 16 studies were included. Meta-analysis showed that the modified Ashworth spasticity assessment scale in the SA group was significantly higher than that in the rehabilitation group (mean difference [MD] = −0.56, 95% confidence interval [CI] [−0.75, −0.37], Z = 5.67, P < .00001). The simplified Fugl-Meyer motor function assessment scale in the SA group was significantly higher than that in the rehabilitation group (MD = 5.86, 95% CI [3.26, 8.46], Z = 4.41, P < .0001). The modified Barthel index assessment scale in the SA group was significantly higher than that in the rehabilitation group (MD = 5.79, 95% CI [4.73, 6.84], Z = 10.77, P < .00001). Additionally, the clinical effective rate in the SA group was significantly higher than that in the rehabilitation group (relative risk = 1.25, 95% CI [1.16, 1.36], Z = 5.42, P < .00001).

Conclusion:
SA combined with rehabilitation therapy has certain advantages in reducing limb spasticity, improving limb function, and enhancing activities of daily living in patients with post-stroke spastic paralysis. This study provides reference and theoretical support for the promotion of SA in the treatment of this condition.
Remimazolam-based anesthesia in a patient with hypertrophic obstructive cardiomyopathy undergoing radical colorectal cancer surgery: A case report
Authors: Shi Yongchang , Zuo Chengchao , Zhang Yiwen , Zhou Chao , Zhang Fengjiao , Zhao Xuelian 
Published: March 2024

Background:
The goal of anesthesia in patients with hypertrophic obstructive cardiomyopathy (HOCM) is to reduce the risk of left ventricular outflow tract obstruction triggered by anesthetics. Remimazolam is a newly developed anesthetic that has been reported to have superior hemodynamic stability. There have been no reports on the completion of non-cardiac surgery with remimazolam in patients with HOCM.

Methods:
Here we report the case of a 49-year-old man diagnosed with hypertrophic obstructive cardiomyopathy who underwent resection of colon cancer with remimazolam and remifentanil anesthesia. A bolus 0.3 mg/kg remimazolam was administered for anesthesia induction, and then adjusted to 2 mg/kg/h to maintain anesthesia. Set the pain threshold index to 50 to auto-control the infusion speed of remifentanil.

Results:
No hypotension occurred during anesthesia, and norepinephrine was not administered. After conversion to open surgery, the patient’s blood pressure elevated and reduced with urapidil and esmolol.

Conclusion:
In this patient with HOCM, remimazolam and remifentanil provided adequate anesthesia for induction and maintenance to complete the right hemicolectomy.