bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localized dumbbell neuroblastoma: A study of 25 cases treated between 1982 and 1987 using the same protocol
Authors: Plantaz Dominique , Hartmann Olivier , Kalifa Chantal , Sainte‐Rose Christian , Lemoine Georges , Lemerle Jean 
Published: February 2007

AbstractAmong the 108 non‐metastatic neuroblastomas treated at the Institut Gustave Roussy between 1982 and 1987, 25 dumbbell neuroblastomas were observed. Therapeutics included: 1) an initial laminectomy in forms with neurological deficit; 2) surgical excision of the primary tumor; 3) preoperative chemotherapy in children in which the primary tumor was considered as unrespectable at diagnosis and postoperative chemotherapy in cases of incomplete resection; and 4) radiation therapy on macroscopic residual disease. Fifteen out of 25 (60%) presented a neurological deficit. A laminectomy was performed in 14 cases. Neurological recovery was good in 4 cases, partial in 4 cases, and absent in 4 cases. Two patients were worse after the procedure. The event‐free survival was 88%. This high survival rate is linked: 1) to the non‐metastatic stage; 2) to a high proportion of children under 1 year of age (18/25) (median age = 7 months); and 3) to a high proportion of thoracic location (12/25). The high incidence of macroscopically incomplete excision (13/25) did not jeopardize the prognosis. Out of the 22 survivors, there were 8 cases of major neurological sequellae (36%) and 5 cases of major orthopedic ones (26%). The coexistence of a serious functional prognosis and an excellent vital prognosis for these patients has led us to analyse the therapeutic modalities, to re‐evaluate the necessity of routine initial neurosurgical removal by laminectomy and to discuss the use of first line chemotherapy. © 1993 Wiley‐Liss, Inc.
Severe acne and hyperandrogenemia following dactinomycin
Authors: Blatt Julie , Lee Peter A. 
Published: February 2007

AbstractThe etiology of dactinomycin‐associated acne has not previously been studied. An 8 1/2 year old girl with embryonal rhabdomyosarcoma of the left petrous bone was prepubertal at the time of presentation. Treatment according to a current Intergroup Rhabdomyosarcoma Study regimen consisted of vincristine, dactinomycin, and cyclophosphamide at 3 to 6 week intervals, as well as hyperfractionated radiotherapy to the tumor bed. Severe acne of the forehead developed within 10 days of starting therapy and resolved over the next 2 months. Serial measurements of serum hormones documented periodic increases in androgen levels coincident with courses of dactinomycin. These observations support a relationship between drug, dermatitis, and hormone levels. Study of other patients will be of interest to document the frequency, degree, and mechanism of hyperandrogenemia following dactinomycin. © 1993 Wiley‐Liss, Inc.
Isolated primary cutaneous aspergillosis of the labia
Authors: Raszka William V. , Shoupe Braden L. , Edwards E. Glenn 
Published: February 2007

AbstractIsolated cutaneous aspergillosis is a rare complication of severe immunocompromised states. We describe a case of isolated cutaneous aspergillosis of the labia minora in an adolescent undergoing treatment for relapsed acute non‐lymphocytic leukemia. The patient was successfully treated with a regimen that consisted of amphotericin B, granulocyte‐colony stimulating factor, and surgical debridement. © 1993 Wiley‐Liss, Inc.
Critical observations on neuroblastoma treatment with 131‐I‐metaiodobenzylguanidine at diagnosis
Authors: Mastrangelo Renato , Lasorella Anna , Iavarone Antonio , Rufini Vittoria , Troncone Luigi , Danza Francesco , Riccardi Riccardo 
Published: February 2007

AbstractResults of treatment with 131‐I‐Metaiodobenzylguanidine (131‐I‐MIBG) in patients with resistant neuroblastoma appear encouraging if one considers that most of the patients had far advanced, intensively pre‐treated disease. To further explore the potential role of this new drug in untreated patients, we treated 3 children with stage III neuroblastoma. All three of our cases received 131‐I‐MIBG at relatively low dose with the complete disappearance of the tumor mass in case 1, whereas in cases 2 and 3 CT scan showed a significant reduction of the tumor mass and, interestingly enough, no evidence of 131‐I‐MIBG uptake of a tracer dose in the remaining tumor. Particularly, in case 2, the persistence and subsequent progression of part of the tumor mass without 131‐I‐MIBG uptake after a therapeutic dose of 131‐I‐MIBG, which apparently destroyed the 131‐I‐MIBG‐positive cell population, clearly suggest heterogeneity at diagnosis, with a dual neuroblastoma cell population, one with 131‐I‐MIBG uptake and the other without. Besides the biological implications of the 131‐I‐MIBG uptake heterogeneity in neuroblastoma at diagnosis, our findings suggest that in stage III neuroblastoma patients even a relatively small dose of 131‐I‐MIBG administered at diagnosis is sufficient to destroy either the primary tumor completely (case 1) or the part of the tumor (case 2 and 3) which shows 131‐I‐MIBG uptake, without any significant hematologic toxicity. Furthermore, a single course of 131‐I‐MIBG at the dosage employed does not appear to jeopardize the subsequent use of chemotherapy. In conclusion, if our data are confirmed by further investigation, 131‐I‐MIBG may be included as a front line drug shortly followed by chemotherapy in future treatment strategies of advanced neuroblastoma without or with minimal bone marrow infiltration. © 1993 Wiley‐Liss, Inc.
Cytogenetic abnormalities in mesoblastic nephroma: A link to Wilms' tumour?
Authors: Roberts Paul , Lockwood Liane R. , Lewis Ian J. , Bailey Clifford C. , Batcup Gillian , Williams Jeffrey 
Published: February 2007

AbstractCytogenetic analysis of tumour material from a congenital mesoblastic nephroma is reported. Two cell lines were found, one with a normal 46,XY karyotype and the other with a hyperdiploid 51,XY karyotype, including a rearrangement of chromosome 11 at 11p15. This finding is of interest since loss of allelic heterozygosity at polymorphic 11p15 loci has been described in sporadic Wilms' tumour [1], and both cytogenetic [2] and molecular [3] changes of 11p15 are found in the Wiedemann‐Beckwith syndrome, a condition with a predisposition to embryonal tumours, particularly Wilms' tumour. Our results lead us to speculate on the implications relating to the pathogenesis of this relatively benign tumour variant with respect to the current understanding of the genetics of Wilms' tumour. © 1993 Wiley‐Liss, Inc.
Salivary gland carcinomas in children: A review of 15 cases
Authors: Taylor Roger E. , Gattamaneni H. Rao , Spooner David 
Published: February 2007

AbstractSalivary gland carcinomas are rare in childhood. We have reviewed the case records of 15 children aged 3–14 years (median 11) identified from children's tumour registries. Primary sites were parotid: 11, submandibular: 3, and base of tongue: 1. The range of histologies was similar to that occurring in adults. Six were treated by complete excision, with one given post‐operative radiotherapy (RT). All six remain disease‐free at 2 months to 21 years after completion of treatment. Five were treated by partial or sub‐total excision. Four were given post‐operative RT, of whom 3 are disease‐free at 3 years, 6 months ‐ 18 years and 1 lost to follow‐up (LTFA). One not given RT developed a local recurrence at 11 months and was given RT and LTFA. Four patients had a biopsy only. Three were treated by RT. One is disease‐free at 8 years, one died of metastatic disease at 6 months, and one developed a local recurrence at 11 years and has remained disease‐free following salvage surgery. One patient with advanced disease not suitable for RT died 3 months after diagnosis. Complete excision is the treatment of choice. Following sub‐total or incomplete excision post‐operative RT can prevent recurrence. Careful RT planning is necessary to minimise late effects. © 1993 Wiley‐Liss, Inc.
Congenital anomalies and genetic syndromes in 173 cases of medulloblastoma
Authors: Evans Gareth , Burnell Liza , Campbell Richard , Gattamaneni H. Rao , Birch Jillian 
Published: February 2007

AbstractOne hundred seventy‐three consecutive cases of medulloblastoma recorded in the Manchester Children's Tumour Registry from 1954 to 1989 were studied. After review of case notes, X‐rays, and health surveys the clinical outcome and incidence of congenital anomaly was determined. A previously unreported association with Rubinstein Taybi syndrome was found. Evidence of a genetic syndrome or congenital anomaly was found in 6.4%. These figures provide further evidence of the higher‐than‐expected incidence of congenital abnormalities. © 1993 Wiley‐Liss, Inc.
Association of malignancy and langerhans' cell histiocytosis: Report of three cases
Authors: De Camargo Beatriz , Alves Antonio Correa , Gorender Ethel F. , Bianchi Alois 
Published: February 2007

AbstractAmong 44 children with Langerhans' cell histiocytosis (LCH) seen at the Pediatric Department of the A.C. Camargo Hospital, São Paulo, Brazil, three developed malignancy, two before and one after the diagnosis of LCH. Malignancy could be attributed to treatment in one of the three children. Whether the cancer in the other two children represents a chance association of the two processes or is treatment‐related, is unknown.
Langerhans' cell histiocytosis presenting with the superior vena cava syndrome: A case report
Authors: Mogul Mark , Hartman Gary , Donaldson Sarah , Gelb Arnold , Link Michael , Amylon Michael , Glader Bertil 
Published: February 2007

AbstractA case of Langerhans' cell histiocytosis confined to the mediastinum and presenting with de novo superior cava syndrome is reported. The causes of superior vena cava syndrome in childhood are discussed as is the importance of obtaining pathologic diagnosis prior to initiating therapy. © 1993 Wiley‐Liss, Inc.
Carcinoma of the choroid plexus: A pediatric experience
Authors: Pierga Jean‐Yves , Kalifa Chantal , Terrier‐Lacombe Marie‐Jose , Habrand Jean‐Louts , Lemerle Jean 
Published: February 2007

AbstractCarcinoma of the choroid plexus (CCP) is a rare tumor of the central nervous system which occurs more frequently in patients under 3 years of age. We report 10 cases of CCP in children. There were 5 males and 5 females, aged 5 to 84 months at diagnosis (median 32 months). Eight CCP were located in the lateral ventricle and 2 in the fourth ventricle. All patients underwent initial surgery, with complete resection in 5 cases. Postoperative treatment included radiotherapy alone in 4 patients, chemotherapy alone in 4, both in 1 patient, and no further treatment in one patient. Six patients remain in first continuous complete remission with a follow‐up of 12 to 156 months (mean 34 months). Five of these six patients had a complete surgical resection of their tumor and 4 of them received chemotherapy alone. A comparison with the series in the literature suggests that total resection of the tumors is the major prognostic factor for survival. Recourse to additional treatments to prevent local relapses and CNS dissemination seems necessary. In our opinion, radiotherapy should be avoided as far as possible because of its deleterious effect in very young children. As some of the long term survivors did not receive radiation treatment, we conclude that CCP can be treated post operatively using chemotherapy protocols designed for infants with malignant brain tumors. © 1993 Wiley‐Liss, Inc.
Chemotherapy in the management of infantile fibrosarcoma
Authors: Kynaston J. Anne , Malcolm Archie J. , Craft Alan W. , Davies Stella M. , Jones Patricia H. Morris , King Derek J. , Mitchell Christopher D. , Oakhill Anthony , Stiller Charles A. 
Published: February 2007

AbstractInfantile fibrosarcoma (IF) has traditionally been treated with surgery, which may have considerable morbidity. Chemotherapy has been suggested in order to reduce the need for extensive surgery. Nine children with histologically confirmed IF who received chemotherapy are described. Six children were treated with chemotherapy initially, two following conservative surgery, and one following recurrence after surgery. All received vincristine (V) and actinomycin D (A), and six received additional drugs including ifosfamide (I), cyclophosphamide (C), adriamycin (Ad), etoposide (E), and cis‐platinum (CDDP). Objective responses were achieved in eight: three responded completely (CR), two responded partially (PR), which allowed conservative surgery, one had stable disease, one had an initial PR, but subsequently had tumour recurrence 1 month after cessation of treatment, necessitating further surgery and chemotherapy, and one had an initial PR but died following local and regional metastases. One child had no response to chemotherapy but is alive with stable residual disease. Thus, five of nine children achieved a CR—three with chemotherapy alone. With the inclusion of chemotherapy as part of their treatment, five children, for whom curative surgery may have resulted in amputation, remain alive with limbs intact. Chemotherapy including V and A should be given to infants with fibrosarcoma in whom curative surgery would be mutilating. © 1993 Wiley‐Liss, Inc.
N‐myc oncogene and urinary catecholamines in children with neuroblastoma
Authors: Barontini Marta , Gutiérrez Marina I. , Levin Gloria , Mur Nora , Diez Blanca 
Published: February 2007

AbstractThis paper reports the analysis of N‐myc amplification, urinary vanillylmandelic acid (VMA), and norepinephrine (NE) excretion and survival in 22 children with neuroblastoma and 7 with ganglio‐neuroblastoma. Five patients had N‐myc amplification (from 30 to more than 200 copies), all of whom had advanced‐stage disease. The urinary excretion of VMA was normal in all of them, only one showed increased NE excretion. All patients with stage C‐D disease and one copy of N‐myc had increased VMA urinary excretion and increased (9/14) or normal (5/14) NE urinary excretion. All patients with stage A or B disease had one copy of N‐myc. Half of them showed increased VMA urinary levels, while only 3/10 showed increased NE urinary values.Comparison of cumulative survival curves in relation to N‐myc amplification and to VMA and NE urinary excretion showed a clear parallelism. Amplification of N‐myc corresponded to normal VMA and NE urinary excretion, and was associated with the worst prognosis (P < 0.01), while increased VMA and/or NE excretion was found in patients with only one copy of N‐myc. © 1993 Wiley‐Liss, Inc.
Clear cell sarcoma of the kidney in a 4‐month‐old infant: A case report
Authors: Newbould Melanie J. , Kelsey Anna M. 
Published: February 2007

AbstractA case of clear cell sarcoma of the kidney is described in a 4‐month‐old male infant. The tumor had a typical histological pattern, consisting of sheets of tumor cells possessing “empty” nuclei set within a delicate capillary network. There was extensive necrosis and tumor cell cytoplasm contained vimentin. This tumor occurs only rarely in infants less than six months of age. The different renal neoplasms of childhood have diverse prognoses and demand specific therapy so that accurate diagnosis is mandatory. The present case illustrates that clear cell sarcoma, a highly malignant neoplasm, must be considered in the differential diagnosis of a renal mass occurring in this age group. © 1993 Wiley‐Liss, Inc.
Avascular femoral head necrosis in pediatric cancer patients
Authors: Hanif Iftikhar , Mahmoud Hazem , Pui Ching‐Hon 
Published: February 2007

AbstractAvascular femoral head necrosis was identified in 15 patients treated at a major pediatric oncology center from 1974 to 1991. The predominant underlying diagnosis was acute leukemia (lymphoblastic, n = 6; non‐lymphoblastic, n = 2); two patients had chronic myeloid leukemia, two Hodgkin's disease, and three other solid tumors. Patients ranged from 7 to 27 years of age at diagnosis of this complication, with a median interval of 25 months (range, 0–11 years) from primary diagnosis. Both steroids and radiation therapy appear implicated in the pathogenesis of avascular necrosis: nine patients had received high cumulative doses of prednisone (3.4–14 g/m2), four had received 35–64.8 Gy local irradiation involving the femoral head, and one underwent total body irradiation (12 Gy). Of the 11 surviving patients, six are asymptomatic and fully active. Two patients have joint pain that is responsive to conservative measures. Severe pain and joint deterioration necessitated arthroplasty in two cases, and a third child is undergoing orthopedic evaluation because of worsening symptoms. Thus, like adult cancer patients, children who receive high doses of steroids or local irradiation involving femoral heads are at risk for avascular necrosis. In patients with chronic myeloid leukemia, the complication may be disease related. Although outcomes in our series are better than those reported in adults, the long period of risk for these children and young adults precludes definitive conclusions. © 1993 Wiley‐Liss, Inc.
Hemihypertrophy, bilateral Wilms' tumor, and clear‐cell adenocarcinoma of the uterine cervix in a young girl
Authors: Stalens Jean‐Philippe , Maton Pierre , Gosseye Serge , Clapuyt Philippe , Ninane Jacques 
Published: February 2007

AbstractWe report the case of a young girl who had hemihypertrophy and developed Wilms' tumor in both kidneys and clear‐cell adenocarcinoma of the uterine cervix with no maternal history of stilbestrol ingestion during pregnancy. Karyotype on the second Wilms' tumor showed monosomy 22. The link between hemihypertrophy and Wilms' tumor is well known, but their association with clear‐cell carcinoma of the cervix has not been previously described. © 1993 Wiley‐Liss, Inc.
Hypertrophic osteoarthropathy in childhood malignancy
Authors: Staalman Christoffel Rudolf , Umans Ulco 
Published: February 2007

AbstractHypertrophic osteoarthropathy (HOA), well known in adults, is rarely encountered in children. The clinical features include clubbing of the fingers and toes, arthritis, and a sometimes painful ossifying periostitis of the tubular bones.Apart from a hereditary form (primary HOA), most of the cases encountered in children are secondary and associated with conditions such as chronic suppurative lung processes (e.g., cystic fibrosis), congenital heart disease, biliary atresia, and polyposis coll. The association with malignant disorders, which is relatively common in adults, is very rare in children. In 1986 the authors published a case report of a patient with carcinoma of the nasopharynx who developed HOA. Another similar patient has been encountered. In both, the appearance of HOA was associated with a very poor prognosis.A meticulous research of the literature from 1890 to 1990 revealed only 24 children (19 boys, 5 girls) under the age of 18, with malignancy and associated HOA. Among them were 10 patients with a carcinoma of the nasopharynx, 8 with osteosarcoma, 3 with Hodgkin's lymphoma, 1 with a periosteal sarcoma, 1 with mesothelioma of the pleura, and 1 with carcinoma of the thymus. In five patients with HOA, there were no abnormalities of the lungs, mediastinum, or pleura, and none developed during the course of the disease.Many authors mention the predictive value of HOA, especially in association with malignant tumors. In contrast to suppurative processes in the lungs, in those with neo‐plastic disease involving the chest, HOA may precede pulmonary symptoms by 1–18 months. A striking feature of HOA in these instances is the reversibility of the complaints after successful treatment of the disorder of the chest, both in benign and malignant conditions.The present case is the second reported by the authors and the first description of a girl with carcinoma of the nasopharynx developing HOA. © 1993 Wiley‐Liss, Inc.
Ifosfamide‐induced subclinical nephrotoxicity and its potentiation by cisplatinum
Authors: Rossi Rainer , Danzebrink Sigrid , Hillebrand Dirk , Linnenbürger Katrin , Ullrich Kurt 
Published: February 2007

AbstractRenal function was assessed in 72 children and adolescents 3.5 to 123 months after completion of chemotherapy employing ifosfamide (n = 39) or ifosfamide plus cisplatinum (n = 33). No patient had preexisting renal parenchymal disease. Whereas reduction in glomerular filtration rate was present in six of 69 patients (8.7%), impairment of tubular transport for phosphate, glucose, and amino acids was more frequent: 32.8% of the patients showed reduction in phosphate reabsorption, and glucose and amino acid reabsorption was lowered in 16.4% and 55.0%, respectively. Elevated sodium excretion was found only occasionally, and there was no evidence of renal tubular acidosis. Proximal tubular damage is related to ifosfamide chemotherapy, but correlation between ifosfamide dose and phosphate reabsorption was not linear. The most severe depletion of phosphate reabsorption was seen in patients treated with both ifosfamide and cisplatinum. On reexamination of phosphate reabsorption after a median interval of 8 months, the majority of patients with initially reduced values showed further deterioration of this function. © 1994 Wiley‐Liss, Inc.
Cervical epidural analgesia for a cancer child at home
Authors: Veyckemans Francis , Scholtes Jean‐Louis , Inane Jacques N , Catheter Cervical Epidural 
Published: February 2007

AbstractA cervical epidural catheter was placed in a 32‐month‐old girl suffering from painful bone metastases of a relapsing neuroblastoma in the left forearm. This therapeutic approach was chosen because oral morphine had failed to provide analgesia while producing intolerable side effects. The epidural injection of a mixture of morphine and bupivacaine provided complete analgesia with no side effects. This enabled the parents to take care of their child at home until the end, 35 days later. © 1994 Wiley‐Liss, Inc.
Total body hyperthermia in combination with etoposide and melphalan in a child with acute myelomonocytic leukemia
Authors: Wessalowski Rüdiger , Willnow Ulrich , Jürgens Herbert , Dehnen Herman , Göbel Ulrich 
Published: February 2007

AbstractIn vitro and clinical studies have shown antineoplastic effects of hyperthermia alone and in combination with other treatment modalities. Synergistic cytotoxic effects of chemotherapy and hyperthermia have been demonstrated on leukemic cell clones in vitro. It seems that hyperthermia is effective in overcoming chemotherapy resistance. Several groups treated solid tumors by using total body hyperthermia (TBHT). However, only a few studies have been reported investigating the clinical effects of TBHT in myeloproliferative disorders. We report the case of a 7‐year‐old boy with myelomonocytic leukemia treated with TBHT (2 hours, 42°) combined with etoposide (600 mg/m2), melphalan (30 mg/m2) and hyperglycemia (200‐300 mg/dl). Within 24 hours after TBHT, the leukemic cells decreased after TBHT from 53,000/μl to zero. Skin leukemic infiltrates, resistant to conventional treatment, also responded well. Although our patient relapsed 34 days after TBHT, these results indicate that TBHT in combination with cytotoxic treatment may be a useful treatment modality in refractory leukemia.
Gastric lymphoma in an 11‐year‐old boy: A case report
Authors: Ashorn Per , Lähde Pirkko‐Liisa , Ruuska Tarja , Mäkipernaa Anne 
Published: February 2007

AbstractA child with prolonged abdominal symptoms was shown to have a concomitant gastric non‐Hodgkin lymphoma and gastritis caused by Helicobacter pylori infection. After a course of antibiotics and 6 months of chemotherapy, the patient is disease free.The relationship of the microbial infection and tumor development is discussed. The case supports a hypothesis that local H. pylori infection may be a predisposing factor for gastric lymphoma. © 1994 Wiley‐Liss, Inc.
Hepatocellular carcinoma in the very elderly: To treat or not to treat?
Authors: Arbaje Yamil M. , Carbone Paul P. 
Published: February 2007

AbstractThe authors briefly review the age distribution of HCC and the treatments used. We concluded that therapy should not be arbitrarily withheld based solely on chronological age. Older cancer patients deserve the right to be treated if they so wish. © 1994 Wiley‐Liss, Inc.