bluuebunny/crossref_metadata_2025_split huggingface dataset:
INCOMPATIBILITY FOR OR PRE‐IMMUNIZATION AGAINST M1s DETERMINANTS DECREASES LETHAL GRAFT‐VERSUS‐HOST REACTION DEVELOPED ACROSS NON ‐ H ‐ 2 AND/OR H‐2 BARRIERS
Authors: Halle‐Pannenko* Olga , Festenstein Hilliard 
Published: April 2007

SUMMARYThe effect of incompatibility for Mls determinants was studied in lethal graft‐versus‐host reaction (GVHR) in the mouse. GVHR was induced in adult recipients of the following H‐2k strains: (AKR x B10.BR)F1 (MlsB/Mlsb); (C3H x B10.BR)F1 (Mlsc/Mlsb); (CBA/J x B10.BR)F1 (Mlsd/Mlsb) and (CBA/H x B10.BR)F1 (Mlsb). Recipient mice were heavily irradiated and grafted with bone marrow and spleen cells from H‐2 compatible B10.BR (H‐2k, Mlsb) or H‐2 incompatible B10.D2 and B10 donors were normal, while those from B10.BR donors were either normal or pre‐immunized against the recipient strains. In all experiments the survival of recipients with Mlsa/Mlsb and Mlsd/Mlsb phenotypes, and only in one experiment of those with Mlsc/Mlsb phenotype was greater and/or the survival time longer than that of recipients expressing only Mlsb. However, late deaths (> 120 days post grafting) observed after grafting of normal B10.BR cells were more frequent in Mlsd/Mlsb than in Mlsb strains. On the other hand, when B10.BR donor cells were pre‐immunized against H‐2k compatible (AKR x B10.BR)F1 (Mlsa/Mlsb) or (CBA/J x B10.BR)F1 (Mlsd/Mlsb) strains, the survival time of H‐2 incompatible (B10 x B10.BR)F1 (H‐2b/k, Mlsb) recipients was longer than when donor cells were pre‐immunized against (CBA/H x B10.BR)F1 (Mlsb) strain. We conclude that donor incompatibility for Mlsa or Mlsd or donor‐pre‐immunization against Mlsa or Mlsd exerts a protective effect on lethal GVHR developed across non‐H‐2 or H‐2 barriers; the protective effect of Mlsc is less efficient or absent. The Mls‐induced protective effect shows the following properties: (a) efficiency in vivo correlates with the capacity of the corresponding alleles to stimulate an in vitro MLR; (b) is efficient in either primary or secondary response to other minor antigens; (c) is not H‐2 restricted; (d) is nonspecific; (e) disappears late after grafting; (f) with respect to the genetic background, the early protective effect is followed, late after grafting, by an opposite effect which increases the mortality, suggesting that M/s locus determinants are capable of activating several cell populations with different biological functions.
MURINE IMMUNE MEMORY TO A TI‐2 ANTIGEN, DNP‐FICOLL: CARRIER‐SPECIFICITY, GENETIC ENHANCEMENT AND PHENOTYPIC DOMINANT INHERITANCE
Authors: Schott C. F. , Lizzio Elaine F. , Merchant B. 
Published: April 2007

SUMMARYC3H/HeN x NZB/BIN F1 mice were primed and challenged with DNP‐Ficoll, a thymic independent (TI‐2) antigen. They developed strong IgM and IgG carrier‐specific memory responses: DNP‐pneumococcal polysaccharide or DNP‐haemocyanin challenge did not elicit memory responses. The IgG response component appeared to be inherited dominantly from the C3H/HeN parent. The IgM component resulted from genetic enhancement.
A MARMOSET T LYMPHOMA WHICH FUNCTIONS AS A HUMAN AMPLIFIER T CELL
Authors: Marchalonis J. J. , Strelkauskas A. J. 
Published: April 2007

SUMMARYA long‐term in vitro grown T cell line derived from a cotton‐topped marmoset (Saguinus oedipus)) infected with Herpesvirus saimiri was found to share surface antigens with human amplifier T cells and to augment the capacity of human B cells to secrete immunoglobulin. This is the first demonstration of T/B collaboration across such a large phylogenetic barrier and might have interesting implications for understanding the nature of molecular interactions mediating cell/cell cooperation.
ANTIBODIES TO HUMAN Ia‐LIKE ANTIGENS AND HETEROLOGOUS ANTI‐HUMAN LYMPHOCYTE SERA
Authors: Wilson B. S. , Ferrone S. 
Published: April 2007

SUMMARYSerolgoical and immunochemical assays detected antibodies to human la‐like antigens in five out of five rabbit antisera to cultured human B lymphoid cells but did not detect them in five bleedings from two rabbits immunized with human peripheral blood lymphocytes. These results, which may reflect differential immunogenicity of la‐like antigens from different cells, indicate that the presence of anti la‐like antibodies in heterologous antihuman lymphocyte sera is not a general phenomenon as reported recently for animal model systems.
SHORT COMMUNICATION: MOUSE MONOCLONAL ANTIBODY AGAINST Lyt ‐ 1.1 ALLOANTIGEN *
Authors: Pierres M. , Rebouah J.‐P. , Liabeuf A. , Dosseto M. 
Published: April 2007

SUMMARYA cloned hybridoma, producing an IgM kappa antibody, has been derived from a fusion between NSI myeloma cells and spleen cells from BALB/c mice immune to CBA lymphocytes. Its specificity for Lyt‐1.1 alloantigen has been established from (1) the lymphoid tissue distribution restricted to T cells and (2) the reactivity pattern on a panel of thymocytes from standard and Lyt congenic mouse strains.
GENETIC LINKAGE AND CELL DISTRIBUTION ANALYSIS OF T CELL ALLOANTIGENS IN THE RAT
Authors: Greiner D. L. , Barton R. W. , Goldschneider I. , Lubaroff D. M. 
Published: April 2007

SummaryThe T cell alloantigens A.R.T.‐1, A.R.T.‐2, Pta, Ag‐F and RT‐Ly‐2 were examined for linkage to albinism and the haemoglobin variant Hbb, and for cell expression similarities in the rat. The A.R.T.‐1 alloantigen was not linked to either A.R.T.‐2, albinism or Hbb. The A.R.T.‐2 alloantigen was demonstrated to be closely associated to albinism and Hbb with a recombination frequency of approximately 3% with albinism and 1% with Hbb. The four recombinants (out of 104 animals examined) were subsequently analysed with alloantisera to Ag‐F, Pta and RT‐Ly‐2. These alloantisera detected an antigenic system(s) which appeared to co‐segregate with A.R.T.‐2 in the recombinants studied Characterization of the specific T cell populations expressing each alloantigen demonstrated that removal of the cells bearing any one of the alloantigens removed all the cells expressing any of the other alloantigens. These results demonstrate that the four alloantigenic systems A.R.T.‐2, Pta, Ag‐F and RT‐Ly‐2 are located in the same genetic region of linkage group I, and appear to be expressed on the same peripheral T cell subpopulation(s) in the rat.
A MONOCLONAL ANTIBODY TO THE HIGH FREQUENCY RED CELL ANTIGEN JMH
Authors: Daniels G. L. , Knowles R. W. 
Published: April 2007

SummaryA monoclonal antibody, H8, was produced which binds to a red cell antigen of very high frequency absent only from the red cells of JMH negative individuals. Serologically H8 reacts like human anti‐JMH.
COMPARISON OF THE SEGREGATION OF SHEEP HISTOCOMPATIBILITY GENES OLA‐A1, A8, B7, B9 AND OLX‐5 IN EIGHTEEN HAMSTER X SHEEP FIBROBLAST HYBRID LINES
Authors: MILLOT P. 
Published: April 2007

SummaryFour OLA factors of the ovine histocompatibility complex and the OLX‐5 factor were recognized in hamster cell x sheep fibroblast hybrids, by means of absorption of OLA reagents with hybrid cells. Segregation of these factors could be studied in eighteen independent hybrids. In the case described, the four OLA factors were distributed into two haplotypes isolated in some hybrids. The heterozygous OLX‐5 factor was linked to only one haplotype; nevertheless a dissociation, occurred in one hybrid (relative to five simultaneous transmissions), is in agreement with a previous genetic study showing a loose linkage between the OLA complex and the OLX locus.
GENETIC PARAMETERS OF THE POLYGENIC REGULATION OF ANTIBODY RESPONSIVENESS TO FLAGELLAR AND SOMATIC ANTIGENS OF SALMONELLAE
Authors: Sant' Anna O. A. , Ferreira V. C. A. , Reis M. H. , Gennari M. , Ibañez O. M. , Esteves M. B. , Mouton D. , Biozzi G. 
Published: April 2007

SummarySelective breedings of mice were carried out for quantitative antibody responsiveness to flagellar Ag., f (Selection III) or somatic Ag., s (Selection IV) of two non cross‐reaction Salmonellae (Salm. tm., Salm. or.) alternated for immunization of consecutive generations. At the selection limit, these selections produced homozygous high (H) and low (L) responder lines for the character investigated: peak agglutinin response to optimal secondary immunization. The responsiveness to both f and s Ags. is submitted to polygenic regulation. The heritability (h2) realized during the selective breeding was 0.37 ± 0.07 for the response to f Ag. and 0.40 ± 0.1 for the response to s Ag. The respective part of genetic and environmental variance in F2 hybrids was 64% and 36% in selection III and 61% and 39% in selection IV. In the two selections, the dominance variance is negligible (<1%), therefore the genetic variance is essentially additive. The additive variance calculated as the heritable fraction of the F2 hybrid variance is somewhat lower, the reason for this difference is discussed. The quantitative antibody response to f Ag. in selection III is controlled by about seven independent loci. The antibody response to s Ag. in selection IV is controlled by about four independent loci. A possible association of relevant genes with the H‐2 locus was investigated. In selection III, no significant participation of H‐2 linked genes, in the regulation of responses to f and s Ags. of Salm, tm and Salm. or. could be demonstrated. In selection IV a partial contribution of H‐2 linked genes was observed concerning responsiveness to both f and s Ags. of Salm. tm.. but not to Salm. or. Ags. The H‐2 effect accounts for 25% of the total interline difference.
ASSOCIATION BETWEEN MATERNAL Gm ALLOTYPE AND NEONATAL SEPTICAEMIA WITH GROUP B STREPTOCOCCI
Authors: Grubb, R. , Christensen,* K. K. , Christensen P. , Lindén V. 
Published: April 2007

SUMMARYThirty‐four mothers to infants seriously infected with group B streptococci (GBS) were investigated for Glm(1) and G3m(5) allotype markers. The frequency of Gm(1, ‐5) was 14.7%, of Gm(1, 5) 20.6% and Gm(‐1, 5) 64.7%. There was a marked deficit of Gm(1) individuals and the distribution significantly differed from that in the normal Swedish population.
ACCELERATED DEVELOPMENT OF Th‐2 TYPE OF HELPER EFFECT IN MRL/MpJ‐lpr/lpr AND BXSB/MpJ MICE
Authors: Matsuzawa T. , Cinader B. 
Published: April 2007

SUMMARYAge‐dependent changes, during adult life, in suppressor capacity and B cell responsiveness have been known for some time. In this paper, an age dependent change in helper function, is being reported. A Th‐2 type of helper effect can be observed in tissue culture of spleen cells from animals sensitized with a macromolecule. An indirect plaque‐forming response to the hapten occurs when the spleen cells are exposed to the sensitizing macromolecule and to the hapten conjugated to a carrier, structurally unrelated to the sensitizing macromolecule. There is considerable polymorphism in the age at which this effect is first demonstrable and at which it reaches mature levels. Mice of inbred strains, with various defects in the suppressor cell circuit (SJL/J, MRL/MpJ‐lpr/lpr, BXSB/MpJ) show an accelerated development of Th‐2 helper capacity in the indirect plaque‐forming response.
IgG HEAVY CHAIN ALLOTYPES (Gm) IN ATROPHIC AND GOITROUS THYROIDITIS
Authors: Nakao Y. , Matsumoto H. , Miyazaki T. , Farid N. R. 
Published: April 2007

SUMMARYWe typed coded sera from 135 healthy controls, seventy‐six patients with autoimmne goitrous and seventy‐three with atrophic thyroiditis for IgG heavy chain markers (Gm). All subjects were Caucasian from Newfoundland. An increase in the Gm phenotype ag was found in the 149 patients with thyroiditis compared to controls (X12= 5.82, P <0.01); significance was, however, not maintained after correction for the number of variables tested. The difference in ag phenotype was more pronounced among the seventy‐three patients with atrophic thyroiditis (X12= 8.80 corrected P < 0.05). Because the haplotype ag was not significantly increased in this group, we conclude that homozygotes for Gm ag are at an increased risk of developing atrophic thyroiditis.
SEROLOGICAL EVIDENCE FOR A PARTIAL t‐HAPLOTYPE IN THE RAT
Authors: Artzt Karen , Lockwood Marilyn , Bennett Dorothea , Kunz H. W. , Gill III T. J. 
Published: April 2007

SUMMARYRecently, Gill and Kunz (1979, 1980) reported an MHC‐linked recessive mutation in the rat, grc, which causes reduced viability and male sterility. Using a mouse anti‐tsemilethal antiserum and a rat anti‐grc antiserum, we have obtained evidence that the grc haplotype codes for t‐antigens.
THE RANGE AND FINE SPECIFICITY OF THE ANTI‐HAPTEN IMMUNE RESPONSE: PHYLOGENETIC STUDIES
Authors: Litman G. W. , Stolen Joanne S. , Sarvas H. O. , Mäkelä O. 
Published: April 2007

SUMMARYHeterodontus francisci(horned shark) andPseudopleuronectes americanus(winter flounder) were immunized with furyl‐oxazolone (furyl‐Ox) and phenyl‐oxazolone (phenyl‐Ox) coupled either to bacteria or protein carriers. The antibodies produced were measured by inactivation of furyl‐ or phenyl‐Ox conjugated bacteriophage, and their affinity and fine specificity were estimated by inhibition of phage inactivation with a series of structurally related hapten analogues. In both species, post‐immunization peak titres were 100 to 2000 times higher than preimmunization titres.A number of unique features distinguishedHeterodontusantibodies fromPseudopleuronectesor mammalian antibodies.Heterondontusantibodies exhibited a lower affinity for the immunizing hapten (furyl‐Ox or phenyl‐Ox) and a reduced ability to distinguish the homologous immunogenic hapten from its structural analogues. In addition,Heterodontusantibodies exhibited a lower level of inter‐individual variation in affinity and fine specificity than didPseudopleuronectesor mammalian IgM antibodies; this was especially prominent in anti‐furyl‐Ox responses. Typically the affinity and fine specificity ofHeterodontusantibodies did not change over the 146‐day period of immunization and were not influenced by the nature of the carrier. The implications of these findings in terms of the phylogenetic origins of antibody diversity are discussed.
A GENE MAPPING BETWEEN THE S AND D REGIONS OF THE H‐2 COMPLEX INFLUENCES RESISTANCE TO TRICHINELLA SPIRALIS INFECTIONS OF MICE
Authors: Wassom D. L. , Brooks B. O. , Babish J. G. , David C. S. 
Published: April 2007

SUMMARYThe strains B 10.S(7R), B 10.S(23 R) and B 10.S(24R), all thought to be genetically identical, differ in levels of susceptibility to infection with Trichinella spiralis. In a series of nine independent experiments, B 10.S(7R) was shown to be more susceptible than the other two strains. In another series of seven experiments, the strain B 10.A(18R) was shown to be more susceptible to infection with T. spiralis than the strains B 10.S(21R) or B 10.BAR‐5, all of which were thought to share common H‐2 alleles. These results indicate that a gene mapping between the S and D loci influences susceptibility to infection with T. spiralis. Typing of these strains for Qa and Tl loci rule out the possibility of a double crossover accounting for the differences observed. The new gene is designated Ts‐2. Previously published data have also been reinterpreted and another gene Ts‐1 is shown to be associated with the Aβ locus. When the d allele is expressed at the Ts‐2 locus, strains of mice expressing s, q, f or b alleles at Ts‐1 are rendered more susceptible to infection.
ANALYSIS OF THE B10.D2‐H‐2d m l MUTANT WITH MONOCLONAL ANTIBODIES
Authors: Tonkonogy Susan L. , Rinchik E. M. , Amos D. B. 
Published: April 2007

SUMMARYWe compared H‐2D products of B10.D2 and the mutant B10.D2‐H‐2dml spleen cells using two monoclonal antibodies designated D3.179 and S11.7. D3.179 reacts with public specificities and appears to define more than one product as shown by cytotoxicity and binding studies. Strong reactivity was obtained in both binding and cytotoxicity and binding studies. Strong reactivity was obtained in both binding and cytotoxicity to B10.D2 and marginal cytotoxicity and low binding were observed with B10.D2‐H‐2dml cells. The second monoclonal antibody S11.7, in contrast, reacts only with H‐2Dd bearing strains and gave strong binding to B10.D2‐H‐2dml and weaker binding to B10.D2. Taken together, the observations indicate that the mutant not only expresses H‐2D, encoded antigens but bear quantitatively greater amounts of some specificities than the parent. A Product of approximately 46,000 daltons was immunoprecipitated from B10.D2 cells by D3.179. Very small amounts of this product were seen in B10.D2‐H‐2dml immunoprecipitates.
STUDIES OF CONGENITALLY IMMUNOLOGICALLY MUTANT NEW ZEALAND MICE: VIII. CELL‐SURFACE PHENOTYPE OF SPLEEN CELLS OF Xid AND NUDE MICE
Authors: Skelly R. R. , Bray K. R. , Gershwin M. E. , Dumont F. , Ahmed A. 
Published: April 2007

SUMMARYSurface immunoglobulin on spleen cells from NZB and NZB/W mice and congenic mice bearing the nude or X‐linked immune defective (Xid) gene was examined by flow microfluorometry with regard to both the frequency of positive cells and density expressed on the cell. These data indicate that although the frequency of unseparated sIg+ B lymphocytes is equivalent among all of these groups of mice, the densities of sIgM and sIgD are different. Spleen cells from these mice were also separated by free‐flow electrophoresis and analyzed in a similar manner. This analysis demonstrated the absence of a subpopulation of B lymphocytes with a low electrophoretic mobility and low expression of sIgM. These studies suggest that maturational and/or activation states of the B cells in mice bearing the Xid or nude genes are different from those seen in the parent strains of mice. Such alterations in cell‐surface antigens correlate with differences in the natural history of immunopathology of the autoimmune disease in these congenic colonies of New Zealand mice.
GENETIC LINKAGE OF SUBGROUP C ROUS SARCOMA VIRUS‐INDUCED TUMOR EXPRESSION IN CHICKENS TO THE IR‐GAT LOCUS OF THE B COMPLEX
Authors: Gebriel G. M. , Nordskog A. W. 
Published: April 2007

SUMMARYTwo B complex genotypes, B1B1 and B19B19, of outbred line S1, were tested for low and high immune response to GAT, from which four recombinants were recovered: B1B1 GAT‐hi and lo, and B19B19 GAT‐hi and ‐lo. Also included in the study were birds of B2B2 genotype with an intermediate level of immune response to GAT.A total of 225 birds of these groups were challenged with the Bryan strain of Rous Sarcoma virus subgroup C, RSV (RAV‐7), by inoculation into the wing web at five weeks of age. The B1B1 genotype had the lowest percentage of regressors (17.6%), B19B19 had the highest (42.2%), and the B2B2 genotype was intermediate (23.7%). Combining the results of GAT response over the B1B1 and B19B19 genotypes, 14.0% of GAT‐lo and 37.8% of GAT‐hi regressed their tumours, respectively. The highly significant (P ≤ 0.01) difference between the combined GAT‐hi and ‐lo groups would suggest that the Rs locus controlling tumour regression induced by the subgroup C virus is closely linked to the region controlling immune response to GAT, but the data also provides evidence that the B‐F region of the B complex also plays an important role in RSV‐induced tumour regression.
LATENT IMMUNOGLOBULIN G (Gm) ALLOTYPES: OCCURRENCE IN THE CEREBROSPINAL FLUID IN SOME NEUROPATHOLOGICAL STATES
Authors: Salier J‐P. , Goust, J‐M. , Link, H. , Pandey J. P. , Daveau Maryvonne , Fudenberg H. H. 
Published: April 2007

SUMMARYGm allotypes were detected and quantitated by radioimmunoassay (RIA) in paired serum and CSF samples from patients suffering from various neurological diseases. Of 115 patients with neurological disorders (65 MS and 50 others), seven subjects displayed one or two allotypes in their CSF which were absent in serum. The Gm phenotype in the patient's serum allowed us to infer the genotype without the need of familial data. A comparison of the regression curves obtained in RIA from the unexpected allotype in CSF and the counterpart in a normal serum pool argued for an identity of the Gm antigen carried by both inhibitory molecules. The unexpected allotype(s) in CSF can be considered as the product of a latent Gm gene which may be activated by either immune perturbations due to the disease per se or some particular immune regulations in the central nervous system.
C4 AND HLA HAPLOTYPES ASSOCIATED WITH PARTIAL INHIBITION OF ANTI‐RG AND ANTI‐CH
Authors: Giles C. M. , Batchelor J. R. , Dodi I. A. , Fielder A. H. L. , Rittner Ch. , Mauff G. , Bender K. , Levene C. , Schreuder G. M. Th. , Wells L. J. 
Published: April 2007

SUMMARYRg and Ch typing was performed, by serum inhibition, on 145 families that had been typed for HLA/C4/BF/C2 with a view to assessing partial inhibition (p.i.) of anti‐Rg/Ch and its haplotype associations. Rg p.i. was found predominatly with the C4A*3A*,2,B*QO homoduplicated C4 haplotype and BFF. The original type of Ch p.i. (Nordhagen et al., 1980) was closely associated with the allotype C4B 2, which also occasionally exhibited complete inhibition (c.i.), but this Ch p.i. was also found with the C4A*1,B*QO haplotype (Rittner et al., 1984a). The second type of Ch p.i. (Giles, 1984) was closely associated with the C4B 1 allotype most frequently in the haplotype C4A*6,B*1 but also with C4A*3,B*1. Both types of Ch p.i. are usually found with BF S. The present data indicate that the determinants of Rg and Ch are not directly related to any particular C4 allotype or extended haplotype.Further examples of C4A 1 with Ch and C4B 5 without Ch determinants have been detected and theoretical considerations are discussed as to how they might have arisen from unequal crossovers in homologous regions that result in hybrid protein molecules.
HUMORAL IMMUNE RESPONSES IN MURINE PREGNANCY
Authors: Bell S. C. 
Published: April 2007

SUMMARYThe relationship between the ability of female inbred mice to produce an anti‐paternal humoral immune response to allogeneic multiparity and the genotype of the female and male strains has been investigated. Only three, all H‐2b haplotype strains, were ‘responder’ strains and produced anti‐paternal alloantibody which did not exhibit C'‐dependent cytotoxicity. ‘Non‐responder’ strains produced no alloantibody in spite of multiple pregnancies with H‐2 and non‐H‐2 incompatible male strains. However, even responder strains did not produce alloantibody with all incompatible male strains. The absence of a response in a responder strain mated with a male strain differing at only the H‐2 locus implicated a role for non‐H‐2 influences. A study of the specificityo of pregnancy‐induced alloantibody suggested that this represented only a fraction of the total alloantibody population induced by conventional immunization in the same strain combination. It is suggested that in pregnancy only the anti non‐H‐2 humoral responses remain similar to those induced by immunization, whereas anti‐H‐2 humoral responses are either absent or are restricted to a fraction of the total foreign H‐2 specificities presented. These observations are discussed in relation to the nature of the immunogenic stimulus in pregnancy and the expression of histocompatibility antigens on the feto‐placental unit.