bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteoclastic giant cell tumor of the pancreas. Aspiration cytology, light microscopy, and ultrastructure with review of the literature
Authors: Manci Elizabeth A. , Gardner Lloyd L. , Pollock William J. , Dowling Edmund A. 
Published: February 2007

AbstractThe osteoclastic giant cell tumor of the pancreas is a rare primary neoplasm that by light and electron microscopy mimics giant cell tumor of bone. In the proper clinical setting, this lesion can be diagnosed by fine needle aspiration. Review of 10 cases reveals a female predominance, a median survival of 12 months, and a tendency for local invasion, rather than lymphatic or distant metastasis, and for invasion of large veins. An epithelial origin is favored for this malignant neoplasm, which expresses varying degrees of mesenchymal differentiation.
Giant cell tumor of bone. A cytologic study of 24 cases
Authors: Sneige Nour , Ayala Alberto G. , Carrasco C. Humberto , Murray John , Raymond A. Kevin 
Published: February 2007

AbstractTwenty‐three patients with radiologic diagnoses of giant cell tumor of bone underwent fine needle aspiration cytology and needle biopsy for tissue diagnosis before curettage or resection. One patient had two tumors, making a total of 24 cases. The accuracy of the cytologic diagnosis was compared with that of tissue biopsy. Cytologically there were mononucleated and multinucleated cells. The former often occurred in clusters or, less often, were dispersed. They had spindle or plump cell bodies with moderate amounts of cytoplasm and well‐defined cytoplasmic membranes. The oval nuclei demonstrated fine, evenly distributed chromatin and small nucleoli. The multinucleated cells were osteoclastlike and were associated with the clusters of mononucleated cells or lying freely. They had a well‐demarcated cytoplasm and contained from a few to several dozen monomorphic nuclei. Cytologic diagnosis was made in 20 of 24 cases, and histologic diagnosis was made in 21 of 24. Insufficient diagnostic material for cytology was the reason for failure in 4 cases. This was attributed to faulty technique (2 cases), cystic change (1 case), and massive necrosis (1 case). As other benign and malignant bone tumors may contain benign giant cells, cytologic or histologic findings alone are not diagnostic of giant cell tumor of bone, but should be complemented with the clinicoradiologic findings. Aspiration cytology is as accurate as tissue needle biopsy, may be of high diagnostic value in deeply located lesions not amenable to cutting needle biopsy, and should be done with full knowledge of the clinicoradiographic information.
Pineal germinoma with widespread extracranial metastases
Authors: Kim Kitai , Koo Bon Chul , Delaflor Richard R. , Shaikh Bahu S. 
Published: February 2007

AbstractA case of primary pineal germinoma with widespread extracranial metastasis in a 36‐year‐old man is presented. A clinical work‐up revealed bilateral pleural effusions, ascites, and metastatic lesions involving the lung. Cytology and electron microscopic study of the pleural and ascitic fluid and of the fine needle aspiration material revealed metastatic germinoma. Although the cytologic features were not distinct from those of anaplastic carcinoma, they were distinguishable from those of glial neoplasms, lymphoma, and sarcoma. The computed tomography findings, elevated human chorionic gonadotropin level, and electron microscopic features contributed significantly to the diagnosis of extracranial metastasis of the pineal germinoma. Metastatic spread most likely occurred via the ventriculoperitoneal shunt.
Radiation‐induced atypia a review
Authors: Murad Tariq M. , August Carey 
Published: February 2007

AbstractA review of radiation‐induced atypia is presented. The radiation changes are divided into acute, intermediate, and late. The presence of cancer cells following irradiation is divided into persistent carcinoma, early recurrent carcinoma, and late recurrent carcinoma. The features of each group are described, supplemented by illustrations depicting the changes. The cytologic changes of radiation are discussed by correlating the light microscopic features with the electron microscopic findings in 8 cases that were studied ultrastructurally.
Cytopathology of asbestos‐associated pulmonary disease
Authors: Greenberg S. Donald 
Published: February 2007

AbstractThe goal of this investigation was to determine the practical role of cytopathology in the clinical and laboratory diagnosis of asbestos‐related pulmonary diseases. For this purpose, sputum, bronchial washings, lung tissues, and pleural fluids were obtained from asbestos workers and controls. The asbestos‐associated pulmonary diseases studied were: (1) asbestosis, (2) carcinoma, and (3) mesothelioma. The cytology smears were prepared with both Papanicolaou and iron stains. Lung tissues were digested by the Chlorox (5.25% sodium hypochlorite solution) technique for quantitation of asbestos bodies. Asbestos bodies within the sputum were found to be highly specific markers for past asbestos exposure, indicating a heavy residual pulmonary asbestos load (>900 asbestos bodies/g wet lung weight). Asbestos bodies in sputum were also found to have a highly significant relationship (P < 0.001) with the degree of accompanying atypia of bronchial epithelial cells. Bronchial washings appeared to be more sensitive than sputum for the detection of asbestos bodies. Asbestos bodies were not found within the pleural fluids of malignant mesotheliomas. It is concluded that sputum cytology screening represents a practical, noninvasive, and inexpensive approach to the diagnosis and study of asbestos exposure.
Gastric remnant cancer after billroth II procedure
Authors: Takeda Misao , Lewis Paul L. , Choi Hong Y. , Nitta Kazuko 
Published: February 2007

AbstractSix cases of gastric remnant cancer that occurred many years after Billroth II gastrectomy and gastrojejunostomy for benign disease are reported. They are classified as intestinal type and gastric type on the basis of their morphologic appearance. Their cytologic and histologic features are tabulated along with a summary of the clinical histories. Emphasis is placed on the possible high risk for patients with Billroth II procedures of developing cancer 10 to 25 years after surgery. Endoscopic follow‐up including cytologic study is essential to diagnose gastric remnant cancer in its early stage to secure a better prognosis.
Occurrence of cilia in exfoliated ovarian adenocarcinoma cells
Authors: Gupta Prabodh K. , Albritton Nancy , Erozan Yener S. , Frost John K. 
Published: February 2007

AbstractCilia identifiable by light microscopy occur extremely rarely in malignant tumor cells. This report documents the presence of cilia on exfoliated malignant tumor cells shed from an ovarian adenocarcinoma. Cilia‐bearing tumor cells were observed in abdominal and pleural fluids. These cilia occurred at atypical locations. They were observed as unipolar, bipolar, lateral, and pericellular structures. Diagnostic features and implications of cilia in relation to malignant cells are discussed.
Fine needle aspiration cytology of myositis ossificans
Authors: Popok Steven M. , Naib Zuher M. 
Published: February 2007

AbstractFine needle aspiration was performed on a large soft tissue mass of the left thigh and hip region in a 27‐year‐old paraplegic man. Cytologic examination revealed sheets of immature fibro‐blasts and scattered skeletal muscle cells in various stages of degeneration compatible with myositis ossificans. This case is probably the first needle aspiration cytology of this lesion. The danger of confusing the cytology with that of a sarcoma is emphasized.
Concurrent discoveries of the value of vaginal smears for diagnosis of uterine cancer
Authors: Koprowska Irena 
Published: February 2007

AbstractThe history of clinical cytology is analyzed in light of the dependence of discoveries upon their cultural environment and past contributions. Simultaneous reports of George N. Papanicolaou and Aurel Babes and their respective originality are compared. Although glorified for saving countless women from death due to uterine cancer, Papanicolaou tried in vain to convey to his peers the importance of a distinct cellular pattern corresponding to cervical intraepithelial neoplastic lesions. The value of this pattern expressing evolutionary steps in the development of cancer at individual cell levels was not appreciated. His terminology was ignored and replaced by histologic diagnoses already familiar to pathologists as well as clinicians. Papanicolaou was the first to describe this pattern, whereas malignant cells in vaginal smears were recognized and used for cancer diagnosis by others before Papanicolaou's work. It is therefore no wonder that the Nobel Prize Committee was at a loss to identify what he discovered. Diagn Cytopathol 1985;1:245–8.
New federal regulations and the future practice of cytology
Authors: Japko Leonard 
Published: February 2007

AbstractAn explanation of the new federal economic initiatives (the Tax Equity and Fiscal Responsibility Act; diagnosis‐related groups) is offered as they currently pertain to the practice of cytopathology. Future trends are discussed, and means to deal with them are recommended. The cytology community can wait no longer to come to grips with changing economic times.
The clinicopathologic significance of vitreous fluid cytology examinations in a series of 38 patients
Authors: Caya James G. , Clowry Lawrence J. , Wollenberg Nancy J. , Aaberg Thomas M. , Tieu Thu M. 
Published: February 2007

AbstractThe authors systematically analyze a series of 38 patients having a total of 40 vitreous fluid cytology determinations. Nine of the 38 patients (23.7%) have cytologic results diagnostic for, or at least highly suggestive of, a specific disease process. These include two cases of bacterial endophthalmitis; two cases of fungal endophthalmitis; one case of vitreal amyloidosis; and four cases called positive for intraocular lymphoma. There are no vitreous fluid cytology determinations falsely positive or falsely negative for malignancy in this series. Intraocular lymphoma and the increasingly important role of vitreous fluid cytology examination in its diagnosis are discussed. The authors conclude that a strong commitment to quality control concepts, including detailed clinical follow‐up, is essential in order to develop clinician trust and help achieve optimal patient care benefit from this valuable diagnostic modality.
Sputum cytology by the saccomanno method in diagnosing lung malignancy
Authors: Risse Elle K. J. , Van't Hof Martin A. , Laurini Richard N. , Vooijs Peter G. 
Published: February 2007

AbstractFrom 1,488 patients, satisfactory sputum was available for cytologic diagnosis. Overall diagnoses were correct in 85.4% of patients, false negative in 193 patients (13.0%), and false positive in 24 patients (1.6%). In patients with a malignant lung process, cytolagic diagnoses were correct in 228 patients (54.2%) and false negative in 193 patients (45.8%). In patients with primary lung cancer, the proportion of correct positive diagnoses increased from 0.47 to 0.87 with one to five sputum specimens examined. In patients with metastatic disease, the figures were 0.35 with one specimen examined and 0.38 with two and more sputum specimens. Cytologic typing accuracy was 67% for large‐cell carcinomas, 73% for adenocarcinomas, 91% for small‐cell lung cancers, and 98% for squamous‐cell carcinomas. For the clinically most relevant groups of non‐small‐cell lung cancer and small‐cell lung cancer, these figures were 99% and 91%, respectively. Diagn Cytopathol 1985; 1:286–90.
Application of immunoperoxidase staining in the cytodiagnosis of herpes simplex keratitis
Authors: Kobayashi Tadao K. , Mizuhara Seiichi , Arai Mari , Sawaragi Isamu 
Published: February 2007

AbstractIn corneal scraping smears from 13 patients with clinically suspected herpes simplex keratitis (HSK), HSK is demonstrated by means of peroxidase‐antiperoxidase (PAP) technique with antisera to herpes simplex virus (HSV) in Papanicolaou‐destained cellular samples. The staining for HSV antigen was present in seven cases of corneal scraping smears with superficial keratitis (dendritic and geographic ulcers) while six cases of stromal keratitis (deep keratitis) failed to show HSV antigen except in one case. Specific antigen for HSV was predominantly present in the cytoplasm rather than in the nucleus. Immunoreactions were negative with HSV antisera in patients with other infections and in those in a normal control group. Using the PAP technique, detection of HSV antigen in corneal scraping smears was of great value in the diagnosis of HSK, especially in cases of superficial keratitis.
Esthesioneur oblastoma: Cytologic features with differential diagnostic considerations
Authors: Fagan Marian F. , Rone René 
Published: February 2007

AbstractA case of recurrent esthesioneuroblastoma was diagnosed by fine‐needle aspiration of a midcervical mass. The cytologic features that characterize this uncommon neoplasm include uniform, small, round‐to‐oval cells with coarsely granular chromatin, multiple small nucleoli, prominent nuclear membranes, and scant cytoplasm. Morphologically and ultrastructurally, esthesioneuroblastoma cells resemble those of sympathetic neuroblastomas. Both tumors show rosette formation and minimal cellular pleomorphism, and, by electron microscopy, dense‐core cytoplasmic granules can be identified. The cytologic recognition of esthesioneuroblastoma is important since it metastasizes to cervical lymph nodes accessible to fine‐needle aspiration biopsy. In addition, the histogenesis of this unusual neuroectodermal tumor and its behavior are discussed.
The cells of benign and malignant hemangiopericytomas in aspiration biopsy
Authors: Nguyen Gia‐Khanh , Neifer Roy 
Published: February 2007

AbstractSamples obtained by fine‐needle biopsy of two benign and one malignant hemangiopericytoma revealed tumor cells with round, oval, or spindle‐shaped nuclei, with variable and ill‐defined filmy cytoplasm. The nuclei had a finely granular chromatin pattern with or without inconspicuous nucleoli. They were seen singly or in loose or dense cellular clusters. Focal gland‐like arrangement of tumor cells was noted in some cellular clusters. Benign endothelial cells were seen among tumor cells and were not cohesive to the latter. The benign and malignant nature of hemangiopericytoma cannot be predicted by examination of the cells present in the aspirates. Also, a specific diagnosis of hemangiopericytoma could not be made on cytologic basis alone as cells of hemangiopericytoma were difficult to differentiate from those of other spindle‐cell mesenchymal tumors.
Aspiration cytology in sweden: The karolinska group
Authors: Linsk Joseph A. 
Published: February 2007

AbstractThe method of aspiration biopsy cytology began to receive international attention after publications, innovations, and courses originating at the Karalinska Hospital in Sweden. Sixten Franzen, Josef Zajieek, Pier Esposti, and Torsten Lowhagen were prime movers of this clinical and scientific development. The history of their arrival at the Karolinska and their seminal contributions is reviewed. Diagn Cytopathol.
Malignant mesothelioma cells in sputum
Authors: Whitaker Darrel , Sterrett Greg , Shilkin Keith , Walters Max 
Published: February 2007

AbstractIn five patients with malignant mesothelioma of pleura, malignant cells, presumably derived from intrapulmonary deposits, were found in sputum specimens. The cells presented mainly as papillary aggregates of epithelial‐like cells, in most cases without specific identifiable mesothelial cell features. In one patient, the specimen was received early in the diagnostic work‐up and led to a strong consideration of the diagnosis of adenocarcinoma. In the remainder, the finding was incidental, occurring after the diagnosis of mesothelioma had been established. The cases are reported to draw attention to this phenomenon, previously unreported in the cytologic literature, and to emphasize that the finding of malignant cells in sputum does not preclude the diagnosis of malignant mesothelioma. Diagn Cytopathol 1986;2:21‐24.
The predictive value of immature dysplastic cells in CIN I and II smears
Authors: Boon M. E. , Kwikkel H. J. , Rietveld W. 
Published: February 2007

AbstractThis paper reports the predictive value of a subclassification of cervical intraepithelial neoplasm grade I and II smears. The follow‐up period was a maximum of 1 yr. The subclassification was based on the presence of immature dysplastic cells (“IDC present”) in the original smear. In 267 cases, these immature dysplastic cells were morphometrically defined. In an additional group of 14 cases, the immature dysplastic cells were exclusively in dense cell groupings which were unsuitable for morphometrical analysis; thus, only visual classification was possible. The predictive value negative (follow‐up with negative findings or CIN I or II) of this method was 1.00. The predictive value positive (follow‐up with CIN III) was 0.14. The sensitivity was 0.98 and the specificity 0.57. On the basis of this subclassification, cases that should be directly referred for further investigation can be selected. It is justifiable to follow‐up the cases that are “IDC absent” with cytology alone. The described method is relatively simple, and can be performed in routine diagnostic laboratories. It is very valuable in settings where most of the initial smears and the follow‐up are in the hands of general practitioners. Using the described method, patients who should be referred to the gynecologist for colposcopy and histology can be selected. Diagn Cytopathol 1986;2:36‐39.
Chordoma: Cytologic and immunocytochemical study of four cases
Authors: Kontozoglou Theodosios , Qizilbash Ali H. , Sianos John , Stead Ron 
Published: February 2007

AbstractWe present the cytologic features and the immunocytochemical profile of four cases of chordoma on fine‐needle aspiration biopsies. The physaliferous cells in signet‐ring, pearl‐like formations and the trabecular arrangement with rounded contours are distinctive. Other cell types and cellular arrangements are also described. The negative immunoreactivity of carcinoembryonic antigen (CEA) and the positive staining pattern for neuron‐specific enolase (NSE), S‐100 protein, epithelial membrane antigen (EMA), and keratin provide a profile that, in the appropriate clinical setting, can be useful in the differential diagnosis of chordoma from similar‐appearing neoplasms in small biopsies and fine‐needle aspirates. Diagn Cytopathol 1986;2:55‐61.
Fine‐needle aspiration biopsy of mucinous cystic neoplasm of the pancreas: A case study
Authors: Emmert Geraldine M. , Bewtra Chhanda 
Published: February 2007

AbstractThis report illustrates the cytologic features of well‐differentiated cystic adenocarcinoma of the pancreas obtained by fine‐needle aspiration biopsy. It also discusses the differentiation of pseudocyst vs neoplastic cyst by this method. Diagn Cytopathol 1986;2:69‐71.
Intraoperative cytodiagnosis of pancreatic adenosquamous carcinoma: A case report
Authors: Leiman Gladwyn , Markowitz Stephen , Svensson Lars G. 
Published: February 2007

AbstractThe cytologic diagnosis by intraoperative fine‐needle aspiration of a case of partially cystic adenosquamous carcinoma of the pancreas is reported. Tissue for histologic confirmation was not obtained. Confirmatory ultrastructural and immunochemical findings are thus presented. Diagn Cytopathol 1986;2:72‐75.
Experience with a modified fine‐needle aspiration biopsy technique in 533 breast cases
Authors: Young Geraldine P. , Somers Robert G. , Young Irving , Kaplan Mark , Cowan Daniel F. 
Published: February 2007

AbstractAspiration cytology depends on skillful preparation of smears, which normally requires a trained cytotechnologist. Collection of aspirates into Saccomanno fixative permits preparation of high‐quality smears by trained technologists no matter who does the aspiration. Aspiration by a surgeon was used with palpation and mammography to examine 533 patients in an office‐based regional breast health program. Lesions sampled ranged from diffuse thickening to frank tumors. Lesions suspicious to any one of the three examinations were biopsed. Cytologically diagnosable material was obtained in 349 instances: 120 were malignant, 22 suspicious, 12 atypical, and 195 benign. Of the 184 yielding insufficient cells, 116 were benign on palpation and mammography, and 68 were suspicious. Biopsy proved 57 of these benign and 11 malignant. There were no cytologic false positives in the study. There was a 2% false‐negative rate on productive aspirates. Nonproductive aspiration occurred in 4.8% of malignant cases. Diagn Cytopathol 1986;2:91‐98.
CT‐guided stereotactic biopsy of intracranial lesions: Correlation between core biopsy and aspiration smear
Authors: Fratkin Jonathan D. , Ward Michael M. , Roberts David W. , Sullivan Margaret M. 
Published: February 2007

AbstractComputerized tomography (CT)‐guided stereotactic biopsies of intracranial lesions in 29 patients were analyzed, paying particular attention to the correlation between core biopsies and aspiration smears. Seven percent were, nondiagnostic due to sampling error. Discrepancies occurred between core biopsies and aspiration smears in 10% of the cases. In two instances of such discrepancies, cytologic findings on the aspiration smear yielded the diagnosis of metastatic tumor. One patient, with herpetic encephalitis, was diagnosed by electron microscopic review of the core biopsy only. One patient died of an intraoperative hemorrhage, a complication of the fine‐needle technique. Diagn Cytopathol 1986;2:126‐1 32.
Cytologic detection of Pneumocystis carinii: A comparison of papanicolaou and other histochemical stains
Authors: Guarner Jeannette , Robey Susan S. , Gupta Prabodh K. 
Published: February 2007

AbstractPneumocystis carinii, a common pathogen among immunocompromised patients, has been investigated in cytologic specimens using both the histochemical stains and ultraviolet (UV) fluorescence following Papanicolaou staining. We reviewed 57 pulmonary cytologic specimens obtained from 23 patients and compared the results of specific histochemical stains and Papanicolaou‐stained preparations under UV excitation. Specific Pneumocystis fluorescence was observed in 26 of 49 Papanicolaou‐stained specimens. Thirty‐seven specimens were examined using both histochemical staining and after Papanicolaou UV staining. A comparison of the two techniques showed the Papanicolaou UV technique to have 89% sensitivity and 95% specificity. Cellulosic filters were the most valuable Papanicolaou‐stained preparation for Pneumocystis diagnosis. The authors conclude that UV fluorescence of Papanicolaou‐stained specimens obtained by noninvasive procedures is a rapid, accurate, and economical method for diagnosing pulmonary Pneumocystis carinii infections. Diagn Cytopathol 1986;2:133‐137.
Meibomian gland carcinoma initially identified by cytology
Authors: Das Dilip K. , Das Jayachandra , Natarajan Radha , Chachra Krishan Lal , Bhambhani Suresh 
Published: February 2007

AbstractA 60‐year‐old female presented with a growing tumor of her left upper eyelid of 6 mo duration. The fine‐needle aspiration cytology (FNAC) report was consistent with the clinical diagnosis of meibomian gland carcinoma, which was subsequently confirmed by histopathologic examination of tumor tissue. Exenteralion was performed following a course of radiotherapy. There was no sign of recurrence after a follow‐up period of 6 mo. Diagn Cytopathol 1986;2:154 156.