bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clofarabine monotherapy in aggressive, relapsed and refractory Langerhans cell histiocytosis
Authors: Parekh Deevyashali , Lin Howard , Batajoo Akanksha , Peckham‐Gregory Erin , Karri Vivekanudeep , Stanton Whitney , Scull Brooks , Fleishmann Ryan , El‐Mallawany Nader , Eckstein Olive S. , Prudowsky Zachary D. , Gulati Nitya , Agrusa Jennifer E. , Ahmed Asra Z. , Chu Roland , Dietz Matthew S. , Goldman Stanton C. , Hogarty Michael D. , Imran Hamayun , Intzes Stefanos , Kim Jenny M. , Kopp Lisa M. , Levy Carolyn Fein , Neff Philip , Pillai Pallavi M. , Sisk Bryan A. , Schiff Deborah E. , Trobaugh‐Lotrario Angela D. , Walkovich Kelly , McClain Kenneth L. , Allen Carl E. 
Published: March 2024

SummaryOver 50% of patients with systemic LCH are not cured with front‐line therapies, and data to guide salvage options are limited. We describe 58 patients with LCH who were treated with clofarabine. Clofarabine monotherapy was active against LCH in this cohort, including heavily pretreated patients with a systemic objective response rate of 92.6%, higher in children (93.8%) than adults (83.3%). BRAFV600E+ variant allele frequency in peripheral blood is correlated with clinical responses. Prospective multicentre trials are warranted to determine optimal dosing, long‐term efficacy, late toxicities, relative cost and patient‐reported outcomes of clofarabine compared to alternative LCH salvage therapy strategies.
Impact of an enhanced recovery protocol in frail patients after intracorporeal urinary diversion
Authors: Zennami Kenji , Kusaka Mamoru , Tomozawa Shuhei , Toda Fumi , Ito Kazuki , Kawai Akihiro , Nakamura Wataru , Muto Yoshinari , Saruta Masanobu , Motonaga Tomonari , Takahara Kiyoshi , Sumitomo Makoto , Shiroki Ryoichi 
Published: March 2024

ObjectiveTo determine whether an enhanced recovery after surgery (ERAS) protocol enhances bowel recovery and reduces postoperative ileus (POI) in both non‐frail and frail patients after robot‐assisted radical cystectomy with intracorporeal urinary diversion (iRARC).Patients and MethodsThis retrospective cohort study included 186 patients (104 with and 82 without ERAS) who underwent iRARC between 2012 and 2023. ‘Frail’ patients was defined as those with a low Geriatric‐8 questionnaire score (≤13). The primary outcomes were postoperative bowel recovery and the incidence of POI. Secondary outcomes included length of stay (LOS), 30‐ and 90‐day complications, 90‐day readmission rate, and POI predictors.ResultsThe ERAS group exhibited a significantly shorter LOS, early bowel recovery, a lower POI rate, fewer 90‐day high‐grade complications, and fewer 90‐day readmissions than the non‐ERAS group in the entire cohort. Non‐frail patients in the ERAS group had a lower rate of POI (7.1% vs. 22.1%; P = 0.008), whereas ERAS did not reduce POI in frail patients (44.1% vs. 36.6%; P = 0.50). In the multivariate analysis, ERAS was associated with a reduced risk of POI in both the entire cohort (odds ratio [OR] 0.39, P = 0.01) and in non‐frail patients (OR 0.24, P = 0.01), whereas ERAS was not likely to reduce POI (OR 1.14, P = 0.70) in frail patients. Prehabilitation was identified as a favourable predictor of POI.ConclusionsThe ERAS protocol did not reduce POI in frail patients after iRARC, although it enhanced bowel recovery and reduced POI in non‐frail patients. Prehabilitation for frail patients might reduce POI.
Genetic diversity of lion populations in Kenya: Evaluating past management practices and recommendations for future conservation actions
Authors: Chege Mumbi , Sewalt Bobbie , Lesilau Francis , de Snoo Geert , Patterson Bruce D. , Kariuki Linus , Otiende Moses , Omondi Patrick , de Iongh Hans , Vrieling K. , Bertola Laura D. 
Published: March 2024

AbstractThe decline of lions (Panthera leo) in Kenya has raised conservation concerns about their overall population health and long‐term survival. This study aimed to assess the genetic structure, differentiation and diversity of lion populations in the country, while considering the influence of past management practices. Using a lion‐specific Single Nucleotide Polymorphism (SNP) panel, we genotyped 171 individuals from 12 populations representative of areas with permanent lion presence. Our results revealed a distinct genetic pattern with pronounced population structure, confirmed a north‐south split and found no indication of inbreeding in any of the tested populations. Differentiation seems to be primarily driven by geographical barriers, human presence and climatic factors, but management practices may have also affected the observed patterns. Notably, the Tsavo population displayed evidence of admixture, perhaps attributable to its geographic location as a suture zone, vast size or past translocations, while the fenced populations of Lake Nakuru National Park and Solio Ranch exhibited reduced genetic diversity due to restricted natural dispersal. The Amboseli population had a high number of monomorphic loci likely reflecting a historical population decline. This illustrates that patterns of genetic diversity should be seen in the context of population histories and that future management decisions should take these insights into account. To address the conservation implications of our findings, we recommend prioritizing the maintenance of suitable habitats to facilitate population connectivity. Initiation of genetic restoration efforts and separately managing populations with unique evolutionary histories is crucial for preserving genetic diversity and promoting long‐term population viability.
Transparency and citizen support for public agencies: The case of foreign aid
Authors: Heinzel Mirko , Reinsberg Bernhard , Swedlund Haley 
Published: March 2024

AbstractCan public agencies boost support for their mandate by being more transparent? We examine this important question in the context of foreign aid. Skepticism about foreign aid spending is common among citizens. This article argues that bilateral aid agencies can increase support for foreign aid by enhancing transparency. The article presents findings from three survey experiments involving a representative sample of 2058 British citizens, as well as observational data at the cross‐national level. The results suggest that transparency reforms are among the most effective institutional interventions for increasing public support. They also suggest that transparency is most effective at increasing public support amongst those who are initially more skeptical of aid and the civil service. Finally, they suggest that citizens do not have strong preferences about the type of information disclosed. They reward all types of transparency.
Estimating the economic effects of US state and local fiscal policy: A synthetic control method matching‐regression approach
Authors: Rickman Dan S. , Wang Hongbo 
Published: March 2024

AbstractIn this paper, we advance the empirical literature on US state and local fiscal policymaking by using the synthetic control method (SCM) to create pairwise matches for states in subsequent regression analysis of the relationships between state and local fiscal policies and several state economic outcomes. Additional contributions include the use of principal component analysis to construct broader narratives of state economic performance and to reduce the dimensionality of the characteristics used in SCM matching, while the regressions also include variables to control for post‐matching economic shocks. Compared to conventional regression analysis, the SCM matching‐regression approach better addresses potential endogeneity, reduces interpolation bias, and creates fiscal policy measures that better reflect policy differences. The SCM‐matched regressions produce more statistically significant relationships between state and local fiscal variables and economic outcomes than do the conventional unmatched regressions, suggesting improved identification of state and local fiscal policy effects on economic outcomes. Robust relationships found include negative economic effects of the own‐source revenue burden and property taxes. Consistent with the existing literature, the estimated fiscal policy effects are quantitatively small and unlikely to drive differences in state economic performance.
Analysis of microbial community succession and characteristic flavour during dry ageing of Yanbian beef
Authors: Wang Yuxuan , Peng Anqi , Zhao ChangCheng , Sun Depeng , Li Tingyu , Wang Juan , Li Hongmei , Mu Baide , Li Guanhao , Piao Chunxiang 
Published: March 2024

SummaryDry‐aged beef is highly regarded for its unique flavour and nutritional value, yet gaps persist in our understanding of its microbial community structure, flavour pathways, and microbe–flavour relationship. In this study, Yanbian cattle buttocks were dry‐aged under varying temperature and humidity conditions and a wind speed of 1.2 m s−1. High‐throughput sequencing was used to assess microbial community diversity. In dry‐aged beef, the predominant bacterial phyla were Proteobacteria and Firmicutes, with the dominant genera including Candidatus Bacilloplasma, Streptococcus, ZOR0006, and Lactobacillus. Fungal communities were dominated by Ascomycota and Basidiomycota, featuring prominent genera including Aspergillus, Fusarium, Alternaria, and Cladosporium. During dry ageing, Yanbian beef flavour metabolites exhibited a significant increase in certain flavour amino acids, total amino acids, and volatile flavour compounds. Most of the metabolites are concentrated near the Penicillium. This study contributes to understanding the characteristic flavours in dry‐aged beef and the microbial fermenters involved in this process.
Effects of fat unsaturation degree on whipping performance and foam stability of fat‐reduced aerated emulsions
Authors: Gao Ziwei , Xu Hua , Fan Qinyuan , Xie Pengkai , Jin Qingzhe , Wang Xingguo , Jin Jun 
Published: March 2024

SummaryAerated emulsions formulated with vegetable oils have been widely consumed with health demands of tea‐based drinks and coffee. In comparison with its traditional counterparts consisting of 30%–40% of fats, that is, whipping creams, the aerated emulsions containing less than 20% vegetable oils are classified as low fat‐cream‐like products and popular with consumers preferring fat‐reduced foods. However, unstable whipping capabilities are the typical quality defects of these low fat‐emulsions, which is highly related with partial coalescence of fat globules. In the present study, effects of unsaturation degree and fatty acid species of fat matrix on whipping capabilities of the aerated emulsions were evaluated by analysing crystal networks, partial coalescence behaviours, whipping performance, and foam structure and stabilities. Increase of fat unsaturation from 10% to 30% improved fat crystal structure and partial coalescence significantly. In particular, 10%–15% of medium chain‐fatty acids present in the emulsions with 30% unsaturated fats tended to crystallise into well‐packed thicker crystals, and to exhibit the highest partial coalescence rate with nearly 60% of solid fat content at whipping temperature. Both the fat species and unsaturation contributed to forming smooth appearance and desirable foam networks after whipping. In contrast, further increase in unsaturation resulted in significant reduction of adsorbed proteins, contributing to excessive aggregation of fat globules. Therefore, it presented negative effects on partial coalescence as well as foam firmness and stabilities. The results figured out characteristics of fat matrix for the manufacture of low fat‐aerated creams with improved whipping capabilities.
Almond flour a by‐product of oil extraction: nutritional characterisation and impact on rheological properties of premixes for bakery products
Authors: Burbano Juan José , Correa María Jimena 
Published: March 2024

SummaryThe press cake of almond oil extraction contains macro‐ and micronutrients of high nutritional quality. From the milling of this press cake, almond flour (AF) is obtained. The objectives of this work were to evaluate the nutritional and techno‐functional properties of AF and the impact of AF (10%, 20% and 30%) addition on rheological and techno‐functional properties of wheat flour, and maize and potato starches. AF presented a high level of lipids (43.56%), oleic acid being the major one. However, AF presented a long estimated shelf life (18 months). Also, AF was a good source of Mg, P, Cu, Fe, Mn and Zn. Moreover, AF added to wheat flour reduced water absorption and dough farinograph stability. Besides, AF caused a reduction of starch swelling and retrogradation, evidenced by lower peak viscosity and setback values in the viscoamylograph curves of wheat flour; maize and potato starches. This study showed the potential impact of AF use for the development of new bakery products.
Advances of metabolomic in exploring phenolic compounds diversity in cereal and their health implications
Authors: Kathuria Deepika , Thakur Sheetal , Singh Narpinder 
Published: March 2024

SummaryThe field of metabolomics has undergone substantial growth, particularly in its application to cereals and their derived products. This comprehensive analytical technique offers insights into the complex and dynamic metabolic profiles of cereals and their derivatives, thereby contributing to a deeper understanding of the composition, quality, and nutritional aspects of these. Various techniques such as mass spectrometry (MS), chromatography coupled with MS, and nuclear magnetic resonance (NMR) were employed to explore the diverse range of metabolites present in cereals. Studies have focused on different aspects that alter the metabolic profile of cereals and their derived products. The present article elucidates the impact of factors such as genotype, growing conditions, and processing methods on the metabolite composition of cereals. Additionally, it has facilitated the identification of bioactive compounds with potential health benefits, contributing to the development of functional foods. Metabolomics approaches enabled the detection of different phenolics, and other essential metabolites in cereals and their derived products, and their modulatory effects on human health. The advances in metabolomics are considered as a powerful tool for developing innovative and healthier cereal‐based products.
Implications of the storage conditions and production system on the physical properties of eggs: a multivariate data analysis study
Authors: Cozzolino Daniel , Sanal Pooja , Soumeh Elham Assadi , Dekkers Milou Helene , Anderson Molly , Boisen Sheree , Hoffman Louwrens Christiaan 
Published: March 2024

SummaryThe objective of this study was to apply multivariate data analytical methods to evaluate the effect of both storage conditions (cold and room temperature) and production systems (cage and free range) on the physical properties of chicken eggs produced under tropical conditions. The results of this study indicated that most of the physical quality parameters (Haugh units, egg weight, albumin height, yolk colour, shell breaking and shell thickness) measured in the egg samples stored at room temperature (RT) were lower compared with egg samples stored in cold room (CT) conditions. The weight loss rate (WLR) was higher in the egg samples from RT compared with CT conditions. Both egg samples from either CT storage conditions or FR production system had the best quality parameters (high Haugh units, heavy egg weights and low WLR). The highest classification rate using linear discriminant analysis was obtained for the prediction of systems of production where egg samples from cage (C) and FR were 83% and 80% correctly classified. However, the classification of weeks of storage provides with intermediate classification results based on the physical parameters measured where 75% and 72% of the samples were correctly classified as stored in CT or RT storage conditions, respectively. The utilisation of multivariate data analysis allowed for the analysis of all the variables at the time without the need to isolate effects such as birds age, housing systems or by the solely interpretation of a single parameter.
Effect of the electrostatic field on fish deterioration: the case of the European anchovy (Engraulis encrasicolus)
Authors: Fiorile Giovanni , Puleo Sharon , Ferraioli Annachiara , Cantone Alessandra , Valentino Vincenzo , De Filippis Francesca , Torrieri Elena , Di Monaco Rossella 
Published: March 2024

SummaryThe European anchovy (Engraulis encrasicolus) being a species very rich in long‐chain fatty acids, it is subject to rapid spoilage with consequent sensory losses. Therefore, this study aimed to verify the effect of a low‐voltage electrostatic field (DENBA+) on the quality of fresh anchovies in a refrigerated environment. During 9 days of storage, anchovy samples were analysed from a chemical (TVB‐N and TBARS), physical (texture analysis), microbiological (microbial count) and sensory (QIM) point of view and compared to control samples (without the electrostatic field). DENBA+ technology was able to reduce of 20% the QI score increment rate with respect to the control sample justified by a better quality of the samples after 7 days of storage. In addition, loads of spoiling microbes were significantly lower in DENBA+ after 9 days of storage. This non‐thermal technology has shown positive effects for long periods of storage.
High color‐purity broad orange‐red emission of Mn2+‐doped transparent phosphate glass–ceramics embedded NaYP2O7 crystals
Authors: Liang Haozhang , Lin Xiangtao , Ma Nanshan , He Longqing , Tong Juxia , Luo Zhiwei , Ye Lingying , Lu Anxian 
Published: March 2024

AbstractIn this work, novel Mn2+‐doped transparent NaYP2O7 glass–ceramics were prepared through melt‐quenching and subsequent thermal treatment. The surface crystallization method was confirmed based on the differential scanning calorimeter, X‐ray diffraction, and scanning electron microscope characterization. As the increase and prolong of the heat‐treatment temperature and time, the crystallinity of the NaYP2O7 glass–ceramics increases, while the transmittance gradually decreases. The optimal heat‐treatment regime is identified to be crystallized over 4 h at 580°C based on the crystallinity and transmittance. Under the excitation of 408 nm, both the Mn2+‐doped precursor glass and glass–ceramic crystallized at 580°C for 4 h generate a broad emission at 620 nm (4T2(g)→6A1(s)) with a full width at half‐maximum (FWHM) of ∼107 nm. The glass–ceramics exhibit higher emission intensity and longer decay lifetime than that of precursor glass with the aid of the low phonon energy NaYP2O7 crystals. The Mn2+‐doped glass–ceramic exhibits stable orange‐red luminescence with the chromaticity coordinates of (0.568, 0.428), low correlation color temperature of 1 800 K, high color purity of 98.88%, and low thermal quenching (70% at 373 K of the initial intensity at 298 K). The above results indicate that Mn2+‐doped transparent NaYP2O7 glass–ceramics have promising potential for orange‐red color display devices.
The effect of early childhood caries on chewing function and tolerated food texture levels in preschool children
Authors: Mustuloğlu Şeyma , Özsin Özler Cansu , Uzamış Tekçiçek Meryem , Serel Arslan Selen 
Published: March 2024

AbstractBackgroundThe early form of caries can affect solid food consumption.ObjectiveThe aim of the study was to evaluate the effect of oral health status on chewing performance, and tolerated food texture among preschool children suffering from early childhood caries (ECC).MethodsA cross‐sectional study was conducted with a sample of 109 children aged between 3 and 6 years, who were allocated to three groups (severe‐ECC (s‐ECC), ECC and control) on the basis of their caries. Chewing function was evaluated by using the ‘Karaduman Chewing Performance Scale (KCPS)’ and the Turkish version of the ‘Mastication Observation and Evaluation instrument (T‐MOE)’, and the tolerated food texture was determined by the ‘International Dysphagia Diet Standardization Initiative (IDDSI)’. Carious lesions, oral hygiene and gingival health status were evaluated by using the ‘decayed, missing, filled tooth/surface indices (dmft/s)’, ‘plaque and gingival indices’; respectively.ResultsA total of 56 children (51.4%) had s‐ECC, 39 (35.8%) had ECC and 14 (12.8%) had no caries (control group). KCPS showed that 26 (86.7%) children suffering from s‐ECC were at level 1, and 11 (100%) children were at level 2. Seven (100%) children with s‐ECC had IDDSI level‐5. All children with healthy oral status had IDSSI level‐7. Compared to the ECC and control groups, the s‐ECC group had significantly lower scores from the T‐MOE total and subscale scores (p < .001).ConclusionThe evaluation of chewing performance during routine dental examinations of children with ECC (especially s‐ECC) may considerably contribute to the early diagnosis of chewing problems and the provision of necessary oral rehabilitation.
Too sensitive or not sensitive enough? Sensitivity to context and justice‐involved youths' response to violence exposure
Authors: Sbeglia Colleen , Smith Curtis Donovyn , Frick Paul J. , Steinberg Laurence , Cauffman Elizabeth 
Published: March 2024

AbstractWith high rates of violence exposure among justice‐involved youth, it is critical to identify factors that might impact the likelihood of youth engaging in violence themselves. One such factor is sensitivity to context, which describes how sensitive youth are to experiences in their environment. Using an ethnically diverse sample of justice‐involved male adolescents (47% Latino, 38% Black/African American, 15% White) aged 13‐17 at the time of their first arrest, the results of this study indicate that exposure to violence was related to increased violent behavior six months later, and this effect was strongest among youth who were low in sensitivity to context. These findings may help practitioners identify which youth are at greatest risk for violence in a policy‐relevant population.
Genetic analysis of impaired healing responses after periodontal therapy in type 2 diabetes: Clinical and in vivo studies
Authors: Nakagawa Keita , Watanabe Kazuki , Mizutani Koji , Takeda Kohei , Takemura Shu , Sakaniwa Eri , Mikami Risako , Kido Daisuke , Saito Natsumi , Kominato Hiromi , Hattori Atsuhiko , Iwata Takanori 
Published: March 2024

AbstractObjectiveThis study aims to investigate the mechanisms underlying the impaired healing response by diabetes after periodontal therapy.BackgroundOutcomes of periodontal therapy in patients with diabetes are impaired compared with those in patients without diabetes. However, the mechanisms underlying impaired healing response to periodontal therapy have not been sufficiently investigated.Materials and MethodsZucker diabetic fatty (ZDF) and lean (ZL) rats underwent experimental periodontitis by ligating the mandibular molars for one week. The gingiva at the ligated sites was harvested one day after ligature removal, and gene expression was comprehensively analyzed using RNA‐Seq. In patients with and without type 2 diabetes (T2D), the corresponding gene expression was quantified in the gingiva of the shallow sulcus and residual periodontal pocket after non‐surgical periodontal therapy.ResultsLigation‐induced bone resorption and its recovery after ligature removal were significantly impaired in the ZDF group than in the ZL group. The RNA‐Seq analysis revealed 252 differentially expressed genes. Pathway analysis demonstrated the enrichment of downregulated genes involved in the peroxisome proliferator‐activated receptor (PPAR) signaling pathway. PPARα and PPARγ were decreased in mRNA level and immunohistochemistry in the ZDF group than in the ZL group. In clinical, probing depth reduction was significantly less in the T2D group than control. Significantly downregulated expression of PPARα and PPARγ were detected in the residual periodontal pocket of the T2D group compared with those of the control group, but not in the shallow sulcus between the groups.ConclusionsDownregulated PPAR subtypes expression may involve the impaired healing of periodontal tissues by diabetes.