bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Definition Transcranial Direct Current Stimulation–Primed Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
Authors: Jaiswal Alankrit , Goyal Nishant , Shreekantiah Umesh 
Published: February 2024

Treatment-resistant depression (TRD) is a common problem faced by clinicians worldwide with no agreed upon treatment protocol. Priming is a technique that can enhance the sensitivity of the brain to therapy using techniques that increase or decrease the excitability of the cortex. Studies on cross-modality priming remain sparse.

Objectives
The aim of this study was to evaluate whether high-definition transcranial direct current stimulation (HDtDCS) priming improves the efficacy of intermittent theta burst stimulation (iTBS) in improving TRD.

Methodology
A prospective hospital-based, randomized control study where the participants were divided into active or sham HDtDCS-primed iTBS stimulation groups for a total of 10 sessions and were assessed on clinical parameters at baseline, end of week 1, and end of week 2 was done. Primary outcome of the study was the difference in Hamilton Depression Rating Scale (HDRS) scores over 2 weeks of HDtDCS-primed iTBS.

Result
A significant effect of time was seen over HDRS scores in both active and sham groups with a large effect size. Significant effect of time was also found over the Clinical Global Impressions-Severity Scale scores of patients with a large effect size. The difference in the improvement in depressive severity as measured using HDRS and Clinical Global Impressions-Severity Scale scores between active and sham groups was also found to be significant with large effect sizes.

Conclusion
High-definition tDCS–primed iTBS is superior to normal iTBS in patients with depression who have failed a trial of 2 antidepressants, whereas both mechanisms are of benefit to the patients.
The fight for our personal data: analyzing the economics of data and privacy on digital platforms
Authors: Iman Nofie 
Published: February 2024

Purpose
Personal data is a powerful tool. The more someone know about us, the more power they got over us. But who will control the most of our personal data? Does the government and the big tech really care about our personal data? This paper aims to look at data practices, data-related policy making as well as its economic consequences in the context of emerging economies.

Design/methodology/approach
Using qualitative methods such as literature review and analysis of numerous government documents, this paper inquires into the dynamics in the use of data by the business sectors, explains how data governance can add value to the business sectors while ensuring customers’ data privacy protection based on the data governance mechanism framework and details what it takes.

Findings
Using the case of Indonesian recent development on data privacy regulation, this paper describes the problems and threats to personal data protection. The advent of latest computing and mobile technology is shifting power relations between the governments, the big tech, as well as the end users. To conclude, the strategy and policy recommendations for implementing data privacy protection are also presented.

Originality/value
This paper provides a timely synthesis of data practices in the context of developing countries, particularly in relation to policy making and economic consequences. This paper also identifies and shares several promising future research ideas.
Intraspecific genetic divergence of the subalpine shrubby variety Quercus crispula var. horikawae from the mountain tree variety Q. crispula var. crispula in Japan
Authors: San Jose‐Maldia Lerma , Matsumoto Asako , Nagamitsu Teruyoshi , Ueno Saneyoshi , Tsumura Yoshihiko 
Published: February 2024

AbstractEcotypic divergence in tree taxa often occurs in subalpine habitats, where environmental conditions are more stressful than those in lower elevations. In the white oak species in Japan Quercus crispula, the subalpine shrubby variety Q. crispula var. horikawae (Qch) has been recognized in central and northern Honshu. Although Qch has different phenotypes from Q. crispula var. crispula (Qcc), genetic divergence between Qcc and Qch has not been examined yet. Pairs of Qcc and Qch populations in eight locations and additional Qcc and Qch populations around these locations were investigated. Leaf size of Qch was smaller than that of Qcc. Chloroplast DNA haplotypes were shared between the Qcc and Qch populations. In genotypes at 29 nuclear microsatellite loci, genetic diversity did not differ between the Qcc and Qch populations. Principal component analysis and a neighbor‐joining tree of populations based on the genotypes demonstrated that 13 Qcc populations and eight Qch populations were grouped separately, except for three Qch populations that were grouped to Qcc. Climatic conditions in the eight Qch populations were characterized by lower temperature and heavier snowfall than those in the 16 populations of the genetic group of Qcc. These results suggest genetic divergence between Qcc and Qch associated with subalpine climatic conditions, irrespective of leaf size. The origin of the subalpine Qch lineage and the history of ecotypic divergence should be investigated in future genomic studies.
DNA recovery after sequential processing of latent fingerprints on black polyethylene plastic
Authors: Bathrick Abigail S. , Norsworthy Sarah , Plaza Dane T. , McCormick Mallory N. , Slack Donia , Ramotowski Robert S. 
Published: February 2024

AbstractLatent fingerprints on plastic substrates can be visualized by using sequential treatments to enhance the contrast between the fingerprint residues and underlying substrate; however, the extent to which these processes affect subsequent DNA analysis is mostly unknown. Latent fingerprints deposited on black plastic by one donor were visualized with single‐process fingerprint powders (i.e., white powder, bichromatic powder, or bichromatic magnetic powder) or sequential treatments (i.e., laser → reflected ultraviolet imaging system (RUVIS) → CA fuming → RUVIS → Rhodamine 6G, Ardrox, and MBD (RAM) or CA fuming → RAM/laser → bichromatic magnetic powder). Samples were examined after the addition of each treatment. DNA was collected using cotton swabs, extracted, quantified, and amplified. DNA yields, peak heights, number of alleles obtained, and percentage of DNA profiles eligible for CODIS upload were examined. Latent fingerprints processed with the laser and up to three sequential treatments generated DNA profiles with significantly higher peaks heights than those of the untreated samples. Fingerprints processed with the laser and up to two sequential treatments generated DNA profiles with significantly more alleles. All methods beginning with laser enhancement generated more CODIS‐eligible profiles. Additional research is needed to determine the extent to which initial laser enhancement impacts the success of downstream DNA profiling results. Although DNA profile development is not guaranteed due to the variable quantities of DNA contained within latent fingerprints, the selection of an appropriate latent fingerprint visualization method could maximize both fingerprint detection and the generation of CODIS‐eligible DNA profiles.
Gabapentin in drugged driving investigations
Authors: Bierly Jolene J. , Chan‐Hosokawa Ayako 
Published: February 2024

AbstractThe increasing use and misuse of gabapentin pose a major risk to public health and traffic safety. Gabapentin has been approved by the Food and Drug Administration (FDA) since 1993 for adjunctive therapy in the treatment of epilepsy and neuralgia but is increasingly being prescribed for numerous off‐label uses including insomnia, anxiety, depression, and migraine. Reported side effects include blurred vision, drowsiness, and loss of coordination. Driving behaviors such as exiting the lane of travel and crashes have been reported in connection to drugged driving investigations concerning gabapentin. To further assist with the toxicological interpretation of gabapentin in driving under the influence of drugs (DUID) scenarios, a review of approximately 108,000 gabapentin‐positive DUID cases was conducted. Of those, 858 cases met inclusion criteria and underwent additional evaluation. Blood specimens were screened via enzyme‐linked immunosorbent assay (ELISA) and confirmed by liquid chromatography tandem mass spectrometry (LC–MS/MS) for quantitation of gabapentin. This review found an overall DUID gabapentin positivity of 7.9% between January 2020 and December 2022; 17 states from various geographical regions had at least one positive gabapentin DUID case. Observations in six driving and human performance cases where gabapentin was the only drug reported were consistent with the known adverse effects of the medication. Half of the case histories reviewed involved crashes where the driver was determined to be at fault. Additionally, 94% of the cases in this review involved gabapentin in combination with other drugs. The most prevalent drug combinations were opioids and gabapentin present in 64% of cases.
Delimiting the rare, endangered and actively speciating
Authors: Martinet Kristen M. , Harmon Luke J. 
Published: February 2024

Species delimitation is a contentious topic. The genomics revolution initially brought hope that identifying and classifying species would be easier through better methods and more data, but genomics has also brought complexity and controversy to delimitation. One solution can be to collect a larger sample of individuals at a finer geographic scale. But what if taxa are rare and collecting more samples is difficult or detrimental to the organisms at hand? In this issue of Molecular Ecology Resources, Opatova et al. (2023) tackle the ambiguity of species delimitation in rare and endangered trapdoor spiders (genus Cyclocosmia). The authors propose a framework for delimiting species when samples are hard to come by, such as in these rare and cryptic spiders. The authors combine extensive genomic sampling with statistical approaches that consider both the genetic distinctiveness of each population of spiders and how much gene flow occurs between these populations. Their proposed taxonomy balances two opposing signals, structure and gene flow, to count eight lineages of Cyclocosmia, and to point the way for future taxonomic studies of the rare or difficult to obtain.
Theacrine enhances autophagy and inhibits inflammation via regulating SIRT3/FOXO3a/Parkin pathway
Authors: Li Jin , Yan Wenliang , Yuan Hongshan , Ren Fang 
Published: February 2024

AbstractBackgroundPsoriasis, a common chronic inflammatory skin condition, impacts around 2%–3% of the global population. Theacrine is recognized for its potential anti‐inflammatory and antioxidant properties. However, the role of theacrine in psoriasis remains unclear.PurposesTo investigate the effects of theacrine on psoriasis and explore the underlying signaling pathways.MethodsFor imiquimod (IMQ)‐induced Psoriasis‐like mice, the psoriatic inflammation was monitored using Psoriasis Area and Severity Index (PASI). The skin damage was observed using Hematoxylin and Eosin staining. The KI67 and CD4 in skin tissues were assessed using Immunohistochemistry analysis. Western blots were performed to evaluate the expression of Keratin 1 (KRT1), KRT6, LC3, P62, Beclin1, T‐bet, GATA3, RAR‐related orphan receptor (ROR)‐γt, Sirtuin‐3 (SIRT3), Forkhead Box O3a (FOXO3a) and Parkin. Additionally, LC3B expression was analyzed using an immunofluorescent assay, while flow cytometry was performed to analyze the percentage of Th17, Th1, and Th2 positive cells in skin‐draining lymph node.ResultsTheacrine improved skin condition by reducing hyperkeratosis and acanthosis, lowering PASI scores, and decreasing KI67‐positive cells. Theacrine also modulated keratin expression, elevating KRT1 while reducing KRT6 levels. Theacrine enhanced autophagy indicated by an increased LC3‐II/LC3‐I ratio and Beclin1, while reduced P62 levels. Additionally, Theacrine reduced CD4‐positive cells and suppressed Th17 and Th1 cell activation. Theacrine activated the FOXO3a/Parkin pathway by upregulating SIRT3 expression, and down‐regulation of SIRT3 counteracted theacrine's effects in psoriasis‐like mice.ConclusionTheacrine inhibits skin damage, promotes autophagy, and mediates inflammation in IMQ‐induced psoriasis mice via upregulating SIRT3 to activate FOXO3a/Parkin pathway, positioning theacrine as a candidate for psoriasis treatment.
Long‐term efficacy, safety, and cumulative retention rate of antitumor necrosis factor‐alpha treatment for patients with Behcet's uveitis: A systematic review and meta‐analysis
Authors: Guan Xin , Zhao Zerui , Xin Miaomiao , Xia Guangtao , Yang Qingrui , Fu Min 
Published: February 2024

AbstractAimThis study aims to evaluate the long‐term efficacy, safety, and cumulative retention rate of antitumor necrosis factor‐alpha (anti‐TNF‐α) therapy for patients with Behcet's uveitis (BU) using meta‐analysis.MethodsWe searched the Web of Science and PubMed databases for eligible studies up to December 1, 2022. The quality of each identified study was assessed using the Joanna Briggs Institute's case series literature quality assessment tool. Statistical analysis was conducted using Stata 16.0 software with a random‐effects model.ResultsTwelve studies comprising 1156 patients with BU were included in our analysis. We found that 85.0% of patients achieved ocular inflammation remission after receiving anti‐TNF‐α treatment, with a 95% confidence interval (CI) ranging from 78.7% to 90.5%. Additionally, 77.4% (95% CI: 57.5%–92.5%) experienced an improvement in visual acuity (VA). Moreover, the pooled dose reduction of glucocorticoids (GCs) was 11.08 mg (95% CI: −13.34 mg to −8.83 mg). Throughout the follow‐up period, the cumulative retention rate of the medication was 67.3% (95% CI: 53.7%–79.6%). Serious adverse events occurred in 5.8% (95% CI: 3.1%–8.9%) of cases, with the three most common types being severe infusion or injection reactions (2.7%; 95% CI: 0.8%–5.4%), tuberculosis (1.3%; 95% CI: 0.0%–3.9%), and bacterial pneumonia (1.3%; 95% CI: 0.1%–3.4%). Subgroup analysis revealed that ocular inflammation remission rates were 89.3% (95% CI: 81.2%–95.5%) for adalimumab treatment and 83.7% (95% CI: 75.3%–90.8%) for infliximab treatment. The drug retention rate after adalimumab therapy was 70.3% (95% CI: 62.0%–78.0%) compared to 66.4% (95% CI: 48.6%–82.2%) for infliximab treatment. Furthermore, the incidence of severe infusion or injection reactions was 2.2% (95% CI: 0.1%–5.8%) following adalimumab treatment and 3.5% (95% CI: 0.7%–7.7%) following infliximab treatment.ConclusionsAnti‐TNF‐α therapy represents an effective treatment for BU patients with favorable safety profile and high drug retention rate and a potential advantage of adalimumab over infliximab in terms of ocular inflammation remission, drug retention, and the incidence of severe infusion or injection reactions.
The influence of negative urgency and mood inductions on alcohol cognitions
Authors: Wolkowicz Noah R. , Augur Isabel F. , Ham Lindsay S. 
Published: February 2024

AbstractBackgroundNegative urgency (NU), the tendency to act rashly during negative emotional states, is a robust risk factor for alcohol misuse that is posited to function in part through alcohol‐related cognitions. Nonetheless, relatively little research has examined mood‐based fluctuations in such cognitions, which could help to explain how the trait of NU translates to impulsive alcohol‐related behaviors. We examined how NU impacted several alcohol cognitions (positive/negative alcohol expectancies, positive/negative alcohol valuations, and alcohol craving for positive/negative emotional reinforcement) before and after negative, neutral, or positive mood inductions. We hypothesized that NU would predict greater and more favorable endorsement of alcohol and its effects following negative (vs. positive or neutral) mood induction.MethodsParticipants (N = 428) were southern‐midwestern college students recruited for an online experiment. Following the provision of consent, participants rated NU and preinduction alcohol cognitions, and were then randomly assigned to one of three (negative, neutral, or positive) mood inductions; subsequently, postinduction alcohol‐cognition ratings were immediately obtained. We conducted six robust multilevel linear models (one per DV) examining NU's influence on within‐person changes in alcohol cognitions across each mood induction.ResultsNo three‐way interactions were identified and only one two‐way interaction involving NU was identified. There were main effects across mood induction conditions and time points for NU predicting greater endorsement of positive and negative alcohol outcome expectancies, and greater alcohol craving for positive and negative emotional reinforcement.ConclusionsGreater NU predicts greater perceived likelihood of alcohol's effects, alongside greater desire for mood improvement from alcohol. The absence of three‐way interactive effects indicates NU's influence on mood‐dependent fluctuations in alcohol cognitions may manifest over longer timescales (e.g., months and years), involve alternative cognitive processes (e.g., drinking motives and implicit alcohol cognitions), and apply more broadly to desires for mood improvement than purely negative emotional reinforcement.
Factors associated with transitions in tobacco product use states among young adults aged 18–29 years
Authors: Blank Melissa D. , Turiano Nicholas A. , Bray Bethany C. , Milstred Andrea R. , Childers Margaret , Dino Geri , Romm Katelyn F. 
Published: February 2024

AbstractBackground and ObjectivesThis study examined young adults’ tobacco use transitions based on their past 30‐day use states, and identified factors associated with their transitions.MethodsParticipants (N = 12377) were young adults aged 18‐29 years at Wave 1 of the Population Assessment of Tobacco and Health (PATH) study. Self‐reported tobacco use states were categorized by the number of past‐month use days (0, 1–4, 5–8, 9–12, 13–30 days) for cigarettes, electronic cigarettes [e‐cigarettes], traditional cigars, filtered cigars, cigarillos, smokeless tobacco (SLT), and hookah. Multistate Markov models examined transitions between use states across Waves 1–5 of unweighted PATH data and multinomial logistic regressions examined predictors of transitions.ResultsMost young adults remained nonusers across adjacent waves for all products (88%–99%). Collapsed across waves, transitioning from use at any level to nonuse (average 46%–67%) was more common than transitioning from nonuse to use at any level (average 4%–10%). Several factors that predicted riskier patterns of use (i.e., transitioning to use and/or remaining a user across adjacent waves) were similar across most products: male, Black, Hispanic, lower education levels, and lower harm perceptions. In contrast, other factors predicted riskier patterns for only select products (e.g., e‐cigarette and SLT use among Whites).Discussion and ConclusionsFew sampled young adults escalated their tobacco use over time, and escalations for many products were predicted by similar factors.Scientific SignificancePrevention and regulatory efforts targeted towards adolescents should continue, but also be expanded into young adulthood. These same efforts should consider both shared and unique factors that influence use transitions.
Cumulative incidence of and risk factors for BCG infection after adjuvant BCG instillations
Authors: Holmberg Lars , Skogmar Sten , Garmo Hans , Hagberg Oskar , Häggström Christel , Gårdmark Truls , Ströck Viveka , Aljabery Firas , Jahnson Staffan , Hosseini Abolfazl , Jerlström Tomas , Sherif Amir , Söderkvist Karin , Ullén Anders , Malmström Per‐Uno , Liedberg Fredrik 
Published: February 2024

ObjectivesTo investigate the cumulative incidence proportion of disseminated or local Bacillus Calmette‐Guérin (BCG) infections after adjuvant BCG instillations in patients with non‐muscle‐invasive bladder cancer (NMIBC).Patients and MethodsWe analysed the timing and occurrence of BCG infections and absolute and relative risk in relation to patient characteristics available in the Swedish nationwide database ‘BladderBaSe 2.0’. The cumulative incidence proportion of a BCG infection was indicated by a reported diagnosis of tuberculosis (TB) in the patient registry or filing a prescription for tuberculostatic drugs.ResultsThe cumulative incidence proportion was 1.1% at the 5‐year follow‐up in 5033 patients exposed to adjuvant BCG instillations. The incidence rate was highest during the first 2 years after start of BCG instillations. Women had a lower risk than men (hazard ratio 0.23, 95% confidence interval 0.07–0.74). Age and calendar time at diagnosis, comorbidity, tumour risk group, previous medication with corticosteroids, immunosuppressive drugs, or time between transurethral resection of the bladder tumour and commencing the adjuvant BCG instillation were not associated with risk.ConclusionsThese data further supports that the overall risk of a BCG infection after BCG‐instillation treatment for NMIBC is low. The great majority of infections occur in the first 2 years, calling for an awareness of the diverse symptoms of BCG infection during this period. We provide evidence for male sex as a risk factor; however, the statistical precision is low and with a risk of selection bias, making it difficult to rule out the other suggested risk factors without further studies with different approaches.
Long‐term experience with tepotinib in Japanese patients with MET exon 14 skipping NSCLC from the Phase II VISION study
Authors: Morise Masahiro , Kato Terufumi , Matsumoto Shingo , Inoue Takako , Sakamoto Tomohiro , Tokito Takaaki , Atagi Shinji , Kozuki Toshiyuki , Takeoka Hiroaki , Chikamori Kenichi , Shinagawa Naofumi , Tanaka Hiroshi , Horii Eisuke , Adrian Svenja , Bruns Rolf , Johne Andreas , Paik Paul K. , Sakai Hiroshi 
Published: February 2024

AbstractTepotinib is a highly selective MET tyrosine kinase inhibitor (TKI) that has demonstrated robust and durable clinical activity in patients with MET exon 14 (METex14) skipping non–small‐cell lung cancer (NSCLC). In the Phase II VISION study, patients received oral tepotinib 500 mg once daily. The primary endpoint was an objective response by an independent review committee (IRC) according to RECIST v1.1 criteria. The secondary endpoints included duration of response (DOR), progression‐free survival (PFS), overall survival (OS), and safety. Here we report the analysis of the efficacy and safety of tepotinib in all Japanese patients with advanced METex14 skipping NSCLC from VISION (n = 38) with >18 months' follow‐up. The median age of the Japanese patients was 73 years (range 63–88), 39.5% of patients were ≥75 years old, 68.4% were male, 55.3% had a history of smoking, 76.3% had adenocarcinoma, and 10.5% of patients had known brain metastases at baseline. Overall, the objective response rate (ORR) was 60.5% (95% confidence interval (CI): 43.4, 76.0) with a median DOR of 18.5 months (95% CI: 8.3, not estimable). ORR in treatment‐naïve patients (n = 18) was 77.8% (95% CI: 52.4, 93.6), and in patients aged ≥75 years (n = 15), ORR was 73.3% (95% CI: 44.9, 92.2). The most common treatment‐related adverse event (AE) with any grade was blood creatinine increase (65.8%), which resolved following tepotinib discontinuation. Other common treatment‐related AEs were peripheral edema (60.5%), hypoalbuminemia (34.2%), diarrhea (28.9%), and nausea (15.8%). In summary, tepotinib demonstrated robust and durable clinical activity irrespective of age or therapy line, with a manageable safety profile in Japanese patients with METex14 skipping NSCLC enrolled in VISION.