bluuebunny/crossref_metadata_2025_split huggingface dataset:
AdvYOLO: Advanced YOLOv8 Application for Bone Pathology Localization and Classification in Wrist X-ray Images
Authors: Wang Rongxiang , Zhao Jingwen , Liu Xiang , Tang Xian , Shi Yunyu , Wei Lina 
Published: March 2024

Abstract
In the field of pediatric orthopedics, accurate and timely identification of wrist fractures is vital for effective treatment and recovery. Fractures significantly affect daily activities and can lead to long-term health issues. Especially in areas with limited medical resources, or for doctors with less experience, interpreting X-ray images accurately is challenging. This paper introduces the AdvYOLO algorithm, an enhanced version of YOLOv8, trained on the GRAZPEDWRI-DX dataset to diagnose wrist bone pathologies. The integration of the Dilation-wise Residual (DWR) and Large Separable Kernel Attention (LSKA) modules is critical for improving feature extraction and classification, as they allow more effective processing of complex patterns in X-ray images, leading to more accurate diagnostics. The mAP 50 value of AdvYOLO improved from 63.8\% to 68.7\%, achieving state-of-the-art performance in wrist detection. Additionally, the paper presents BoneVisionAI, a tool to assist doctors, particularly those with less experience, in accurately interpreting children's wrist X-rays, aiming to reduce diagnostic errors in the healthcare sector.
Magnetoelectric effect in multiferroic nickelate perovskite YNiO3
Authors: Staub Urs , Hernández Nazaret Ortiz , Skoropata Elizabeth , Ueda Hiroki , Burian Max , Alonso José 
Published: March 2024

Abstract

The interaction of magnetic order and ferroelectric polarization is a fundamental coupling with the prospect for the control of electronic properties and magnetism. The connection among magnetic order, charge localization and associated metal-insulator transition (MIT) is another cornerstone for materials control. Materials that combine both effects are therefore of great interest but so far not established. One of the classes of materials proposed to combine these functionalities is the family of RNiO3 (R: lanthanide or Y), whose members show a clear MIT and an antiferromagnetic ground state, and for which an electric polarization has been predicted. Here, we show by resonant magnetic x-ray scattering with circular polarization that YNiO3 does not only possess a magnetic structure containing domains of spin-rotations that are consistent with the occurrence of electric polarization, but also that there is a significant magnetoelectric interaction that allows manipulation of magnetic domains by an electric field. This shows that charge ordered RNiO3 are magnetoelectric multiferroics with a MIT.
Research on the Biological Potential of Lemon ( Citrus Limon L. Burm.) Peel Extracts as a Multi functional Cosmetic Raw Material
Authors: Huang Jinqing , Xu Xu , Wang Shengdong , Wang Dandan , Xi Linzhi , Liu Chang , Liu Liping 
Published: March 2024

Abstract

The study aimed to explore the potential of lemon peel extracts as a cosmetic raw material, with a focus on their aromatic, antimicrobial and various biological activities. Lemon peel essential oil (PLEO), extract (PLE) and absolute oil (PLAO) were prepared by steam distillation and organic solvent extraction, respectively. The compositions of PLEO, PLE and PLAO were analyzed by GC/MS, revealing 22, 39, and 9 components respectively, with terpenoids being the main component. PLE had the highest total flavonoid content, and surpassing that of total polyphenols. Aroma intensity, measured with an electronic pen, followed the order LPEO > LPE > LPAO, while aroma persistence was ranked LPAO > LPEO > LPE. All three lemon peel extracts showed strong antibacterial (against E. coli, S. aureus, and C.albicans), as well as antioxidant and anti-tyrosinase properties, with inhibition rates exceeding 90% in a dose-dependent manner. LPEO demonstrated superior anti-inflammatory effects compared to LPAO and LPE, with inhibitory rates of 87.79 ± 3.86% and 80.75 ± 2.33% on TNF-α and IL-6 at a concentration of 1×10− 2 mg/mL. Lemon peel extract was found to promote HaCat cell migration, with LPEO showing greater effectiveness than LPE and LPAO. The healing rate of scratched HaCat cells treated with LPEO at a concentration of 1×10− 2 µL/mL for 12 hours was 95.29 ± 3.41%. In conclusion, the combination of these extracts could broaden their applications in cosmetics by offering aroma-enhancing, antioxidant, whitening, antibacterial, anti-inflammatory, and skin wound healing benefits.
Impact of transvaginal cervical cerclage on pregnancy outcomes in women with cervical incompetence
Authors: Guo Yuanyuan , Aziz Aziz ur Rehman , Wang Daqing , Yu Xiaohui 
Published: March 2024

Abstract

Objectives: The transvaginal cervical cerclage performed for the treatment of cervical incompetence (CI) may affect the pregnancy/birth outcomes. The study aims to investigate the clinical effects of transvaginal cervical cerclage at three different operation timings and analyze the factors associated with pregnancy and newborn outcomes.
Methods: We used an improved U-shaped surgical method (patent number ZL 201320151440.8.) for the first time. 80 patients were divided into three groups based on operation timings: preventive (H), stress (U) and emergency (E) groups. These groups were compared in terms of surgical efficacy and factors affecting pregnancy outcomes.
Results: The total pregnancy success rate of the subjects in this study was 80.0%. There was no significant difference in the rate of live birth, late miscarriage, premature birth, and neonatal occupancy among the groups. The 1-minute Apgar score in the H group was the greatest of the groups. Different factors like ureaplasma infection, hypothyroidism, assisted reproductive conception, C-reactive protein, gestational diabetes, polycystic ovarian syndrome, and BMI negatively affected pregnancy outcomes.
Conclusions: The postoperative clinical effect of H group was better than that of U and E groups. The study concluded that our suture method and material were associated with better pregnancy and newborn outcomes among the groups.
A Multifaceted Approach to Injection Mold Design, Analysis and Manufacturing
Authors: Krishnappa Madhukumar , N Channa Keshava Naik , Mallaradhya Mallaradhya Hulikere , Naik Rudra , Islam Saiful , Majdi Hasan Sh , Kumar Sandeep , Kumar Rahul , Anjinappa Chandrashekar , Khan Wahaj Ahmad 
Published: March 2024

Abstract

The injection molding procedure primarily involves a sequential process that converts plastic pellets into a molded item. Through a repetitive cycle, identical components are created by melting resin pellets or powder and then injecting the resulting polymer melt into a hollow mold cavity using high pressure. Injection molding has posed challenges for numerous manufacturers and researchers aiming to create cost-effective products that meet specified criteria. This research explores the holistic process of designing, analyzing, and manufacturing of an injection mold for an air filter box bottom cover, focusing on cost-effectiveness while addressing common challenges in achieving high-quality parts. For the production of this part, a material called Poly Propylene talc filled [PPTF] is employed due to its enhanced stiffness, making it appropriate for this application where dimensional stability is crucial. Through moldflow simulation, potential issues like uneven flow, problematic weld lines, and air traps are identified. Based on these findings, the mold design is optimized by strategically placing gates, controlling weld line position, eliminating gas traps, equalizing pressure drops, and reducing stress levels. The optimized parameters are then implemented in manufacturing, leading to improved part quality through reduced defects and better dimensional accuracy. Additionally, the research helps minimize production costs by reducing rejections and rework. This, multifaceted approach not only streamlines the process but also contributes to the efficient and cost-effective production of high-quality air filter box bottom covers.
A hybrid quantum-classical classification modelbased on branching multi-scale entanglementrenormalization ansatz
Authors: Hou Yan-Yan , Li Jian , Xu Tao , Liu Xin-Yu 
Published: March 2024

Abstract

Tensor networks are emerging architectures for implementing quantum classification models. Branching Multi-Scale Entanglement Renormalization Ansatz (BMERA) is a tensor network known for its enhanced entanglement properties. This paperintroduces a hybrid quantum-classical classification model based on BMERA and explores the correlation between circuit layout,expressiveness, and classification accuracy. Additionally, we introduce an autodifferentiation method for computing the costfunction gradient, which presents a viable option for other hybrid quantum-classical models. Through numerical experiments,we demonstrate the superior accuracy and robustness of our classification model in tasks such as image recognition andcluster excitation discrimination, outperforming quantum classification models based on tree tensor networks and multi-scaleentanglement regularization ansatz.
Study on the Reduction of Residual Stress in Laser Cladding Layers through Groove Texture
Authors: Zhao Changlong , Ma Chen , Du Weilong , Yu Zice , Zhang Zihao 
Published: March 2024

Abstract

In seeking a method to produce crack-free overlay layers, we combined surface texturing technology with laser cladding, establishing a multi-field coupled numerical simulation model. We separately investigated the temperature, stress, and fluid fields in laser cladding processes with and without texturing, seeking optimal cladding parameters, and conducted experiments. Numerical simulation results indicate that pre-set texturing effectively reduces the temperature gradient during the cladding process, making the thermal cycle curve smoother. The residual stresses in the X, Y, and Z directions are reduced by 34.84%, 3.94%, and 50.22%, respectively. The introduction of texturing reduces the internal flow velocity of the melt pool, preventing the occurrence of a double vortex effect. Experimental results demonstrate that, compared to non-textured cladding, pre-set texturing reduces residual stresses in the X, Y, and Z directions by 41.42%, 8.04%, and 47.02%, respectively. This effectively improves surface roughness and internal grain size of the cladding layer, and no apparent defects occur at the metallurgical bonding site. These findings provide valuable insights for enhancing the quality of subsequent cladding layers.
Challenges of Pharmacy Residency Program Publications in Pediatric Oncology Hospital in a Developing Country
Authors: Fikry Sally , Zabni Faihan El , Hassanien Omneya , Zamzam Manal 
Published: March 2024

Abstract
Introduction: Residency program in Children’s Cancer Hospital-Egypt (CCHE) is the first ever accredited international pharmacy practice residency program (IPPR) from American Society of Health System Pharmacist (ASHP). Pharmacy residency programs play a significant role in achieving the goal of highly qualified pharmacist. They give residents the chance to "conduct a practice-related project using effective project management skills" in order to be accredited by the American Society of Health-System Pharmacists (ASHP). The majority of these projects, despite the time and effort invested in them, are only presented at regional and national residency conferences and do not ultimately result in peer-reviewed publications. Recent studies show that pharmacy resident projects have low publication rates. The results of pharmacy residency publication barriers are mostly from studies that surveyed residents and directors in the United States, no studies were done in a developing country.
Objectives: To determine the challenges that are facing the pharmacy residents during project publication in CCHE among the graduated residents from 2019 till 2022 and to evaluate the perceived value of the projects from the preceptors’ prospective.
Method: This was a cross-sectional survey of pharmacy residents and pharmacy preceptors. International pharmacy practice residents (IPPR) who have completed and finished the program during the last four years from 2019 till 2022 were eligible to complete the survey while preceptors who have three or more years of experience in clinical pharmacy were involved.
A list of the graduated residents and the active preceptors was prepared in with the help of the residency program director and an online version of the survey was distributed among them.
Results: A significant barrier identified by half of the residents was the challenge of completing the residency project within a one year. Meanwhile, 41.7% pointed out the lack of allocated time for their projects, and for 33.3%, writing the manuscript posed a challenge. The preceptors acknowledged the significance of the research project as a foundational learning opportunity that hones lifelong learning skills
Conclusion: The primary obstacles impeding the publication process in the context of pharmacy residency programs are the lack of dedicated time and the challenging nature of completing research projects within the limited timeframe of a one-year residency program. To establish an enhanced model that facilitates the successful progression of a pharmacy residency project, encompassing all stages from concept development to peer-reviewed publication, it is imperative to identify and address these barriers.
Self-Interest Overrides Rank-Reversal Aversion in Resource Distribution
Authors: Kim Minyoung , Kim Kun Il , Kim Hackjin 
Published: March 2024

Abstract

The equitable allocation of resources has long been a central concern for humanity, prompting extensive research into various motivations that drive the pursuit of distributive justice. In contrast to one of the most fundamental motives, inequality aversion, a conflicting motive has been proposed: rank-reversal aversion. However, it remains unclear whether this rank-reversal aversion persists in the presence of self-rank. Here we provide evidence of rank-reversal aversion in the first-party context and explore diverse moral strategies for distribution. In a modified version of the redistribution game involving 55 online-recruited participants, we observed rank-reversal aversion only when one’s rank was maintained. When participants’ self-rank was altered, they tended to base their behavior on their new ranks. This behavioral tendency varied among individuals, revealing three distinct moral strategies, all incorporating considerations of rank-reversal. Our findings suggest that rank-reversal aversion can indeed influence one’s distribution behavior, although the extent of its impact may vary among individuals, especially when self-rank is a factor. These insights can be extended to political and economic domains, contributing to a deeper understanding of the underlying mechanisms of distributive justice.
Psychometric properties of Polish version of the 36-item WHODAS 2.0 in individuals with fibromyalgia
Authors: Sozańska Agnieszka , Sozański Bernard , Łagowska Anna , Wilmowska-Pietruszyńska Anna , Wiśniowska-Szurlej Agnieszka 
Published: March 2024

Abstract

Fibromyalgia (FM) is chronic, widespread musculoskeletal pain and accompanying fatigue, sleep disturbances, cognitive, psychological, and somatic symptoms. The aim of the study is to assess the psychometric properties of the Polish version of the 36-item WHODAS 2.0 in FM patients. This is a cross-sectional study involving 456 FM polish patients. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) 36-item version, the Fibromyalgia Impact Questionnaire (FIQ) and Beck's Depression Inventory (BDI) were used as an assessment tool in the study. The internal consistency of the 36-item WHODAS 2.0 was assessed using Cronbach’s alpha. Values ranging from 0.824 to 0.951 were obtained. The interclass correlation coefficients (ICC) were very high. Internal structure of the 36-item WHODAS 2.0 was checked with Confirmatory Factor Analysis (CFA). RMSEA = 0.069, CFI = 0.963, TLI = 0.96, SRMR = 0.081 proved exactness of original six-dimensional structure of WHODAS 2.0. External validity was assessed by correlating the 36-item WHODAS 2.0 scores with the scores of two previously validated tools: FIQ and BDI. Positive correlations were obtained between the 36-item WHODAS 2.0 and these tools. Based on the conducted research, it has been shown that the 36-item WHODAS 2.0 is a reliable and valid tool for assessing disability in individuals with FM in Poland.
Allicin-induced AMPK signaling attenuated canonical TGFβ1/SMAD3 pathway-mediated lung fibrosis
Authors: Nakazawa Shun , Hou Jia , Kato Motoyasu , Togo Shinsaku , Arai Yuta , Motomura Hiroaki , Kurata Koichi , Sueyasu Takuto , Hirakawa Haruki , Ochi Yusuke , Sumiyoshi Issei , Watanabe Junko , Hoshi Kazuaki , Ihara Hiroaki , Kadoya Kotaro , Takahashi Kazuhisa 
Published: March 2024

Abstract
Background: Allicin, a natural compound derived from garlic, protects against oxidative stress-mediated tissue inflammation and vascular remodeling. Although these are key processes in lung fibrosis, the effects of allicin on this disease have never been evaluated. In this study, we aimed to evaluate the effects of allicin on lung fibroblast-mediated lung fibrosis and its underlying mechanisms of action.
Methods: The effects of allicin on fibronectin-mediated lung fibroblast migration and the contraction of three-dimensional type I collagen gels were assessed. Furthermore, the anti-fibrotic effect of allicin was evaluated in a mouse model of bleomycin (BLM)-induced lung fibrosis.
Results: Allicin suppressed TGFβ1-stimulated gel contraction and migration as well as α-SMA and fibronectin expression (P < 0.05). Allicin up-regulated AMP-activated protein kinase (AMPK) phosphorylation while suppressing SMAD3 phosphorylation. AMPK inhibitor further stimulated TGFβ1-induced gel contraction and migration (P < 0.05). Allicin suppressed BLM-induced lung fibrosis and lung injury in a mouse model, with substantial reductions in inflammatory cell infiltration in the bronchoalveolar lavage fluid (P < 0.05).
Conclusion: Allicin may be a candidate therapeutic agent for lung fibrosis. Furthermore, its effects were mediated by AMPK pathways; these findings may guide further research aimed at the development of fibrosis treatments.
Three-dimensional finite element analysis of occlusal stress on maxillary first molars with different marginal morphologies restored with occlusal veneers
Authors: Chen Qing , Luo Siyang , Wang Yujuan , Chen Zhu , Li Ying , Meng Maohua , Li Yamei , Xiao Nan , Dong Qiang 
Published: March 2024

Abstract

BackgroundAs a relatively new fixed prosthesis method, there are differences in the research results at home and abroad regarding which edge design of occlusal veneers can achieve the best long-term success rate. Further research is needed. The three-dimensional finite element method was used to conduct stress analysis on occlusal veneers of maxillary first permanent molars with different thicknesses and margin preparation designs. The aim of this study was to provide mechanical research evidence and a reference for exploring standardized clinical protocols for the design of occlusal veneer restorations of maxillary first molars.MethodA 3Shape was used to scan the maxillary first molar teeth in vitro, after which 3D printing was performed. Three different edge designs were applied to identical model teeth: straight-beveled finishing line(SFL), chamfer finishing line(CFL), and standard cuspal inclination(SCI). Preparation was carried out with a thickness of 0.5 mm. Using the surface deformation feature, the occlusal veneer was thickened by 0.5 mm and 1.0 mm, and periodontal ligaments were added. They were then placed into the upper and lower jaws and dental arches. Finite element analysis was performed after applying bite force dispersion to the loading area on the mandible following dynamic contact.Results1. As the thickness increased, the maximum von Mises stress in the occlusal veneer increased for both the SFL and CFL, while the SCI exhibited the opposite trend. 2. The trend of the maximum von Mises stress in the adhesive layer decreases gradually with increasing thickness of the occlusal veneer. The stress of the SFL and CFL is concentrated primarily at the edge position below the functional cusp, resulting in relatively low adhesive stress. However, in the SCI group, the maximum stress at the edge of the adhesive layer exceeded the maximum shear strength of commonly used adhesives.ConclusionsUnder the experimental conditions, the mechanical properties of the maximum von Mises stress for the SFL, CFL, and SCI Occlusal veneer met clinical needs. Incorporating the minimally invasive concept of tooth preservation, a thickness of 1.0 mm is optimal for glass ceramic occlusal veneers on maxillary first molars. However.
Urine Alkalinization in Preventing Rhabdomyolysis Induced Acute Kidney Injury and Need for Dialysis: A Systematic Review and Meta-analysis
Authors: Safari Saeed , Najafi Iraj , Aghili Seyed Hadi , Kerachi Ali Jamshidi , Shahlaee Mohammad Amin , Sadeghi Alireza , Ranjbar Mehri Farhang 
Published: March 2024

Abstract

Introduction:
Urine alkalinization can reduce the toxic effects of myoglobin on renal tubules, but the effects of alkaline hydration on the outcomes of rhabdomyolysis patients are unclear. This systematic review and meta-analysis aimed to determine the role of alkalinization in preventing rhabdomyolysis-induced acute kidney injury (AKI) and the need for dialysis.
Methods
We conducted a systematic review and meta-analysis following the PRISMA guideline. We searched for relevant articles in multiple databases, removed duplicates, and screened the remaining articles based on title, abstract, and study criteria. Two researchers independently assessed the remaining studies by reading the full text, and any discrepancies were resolved through discussion. We used the ROBINS-I tool to assess the risk of bias and excluded studies with a critical risk of bias from the final analysis.
Results
Out of 9230 initially identified articles, 5 studies met the inclusion criteria to be entered in the meta-analysis. The meta-analysis revealed no significant effectiveness of urine alkalinization in preventing AKI (OR: 2.11 (95% CI: 0.09–47.72), p value: 0.3) or acute renal failure development (OR: 1.26 (95% CI: 0.86–1.84), p value = 0.36) or reducing the need for dialysis (OR: 4.25 (95% CI: 0-3.8e+ 07), p value = 0.25) following rhabdomyolysis.
Conclusion
It seems that, addition of sodium bicarbonate to fluid therapy solution does not significantly protect against AKI, dialysis need, or acute renal failure in rhabdomyolysis patients. Further insight can be gained through conducting controlled randomized clinical trials.