bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Activities and Risk of Dementia in Community-Dwelling Older People: Gender-Specific Findings From a Prospective Cohort Study
Authors: Htun Htet Lin , Teshale Achamyeleh Birhanu , Owen Alice J , Ryan Joanne , Woods Robyn L , Orchard Suzanne G , Hajek André , Lysen Thom , Shah Raj C , Chong Trevor T-J , Sheets Kerry M , Joyce Johanna , Murray Anne M , Freak-Poli Rosanne 
Published: April 2024

Abstract

Objectives
This study examines the gender-specific associations between a wide range of social activities and dementia risk.

Methods
A prospective cohort study was conducted involving community-dwelling older Australians (≥70 years) without significant cognitive impairment at enrolment. During the first year of enrolment, we assessed 25 self-reported social activities covering various aspects, including support from relatives and friends, community participation, social interactions with surroundings, and loneliness. Dementia diagnosis followed DSM-IV criteria, adjudicated by an international expert panel. To estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between social activities and dementia, we performed Cox proportional hazards models, adjusting for age, educational attainment, baseline global cognition, and depressive symptoms.

Results
Among 9,936 participants who completed all social activity questionnaires (median [IQR] age: 73.4 [71.6–77.1] years; 47.4% men), dementia was diagnosed in 3.8% of men (n = 181/4,705) and 2.6% of women (n = 138/5,231) over a median 6.4 years (IQR: 5.3–7.6, range: 0.2–10.1) follow-up. Gender-specific relationships emerged: caregiving for a person with illness/disability in women (HR: 0.65, 95% CI: 0.42–0.99), and having ≥9 relatives feeling close to call for help in men (HR: 0.56, 95% CI: 0.33–0.96; reference &lt;9 relatives) were associated with reduced dementia risk. Unexpectedly, in women, having ≥5 friends with whom they felt comfortable discussing private matters were associated with a greater dementia risk (HR: 1.69, 95% CI: 1.10–2.59; reference ≤2 friends). Imputed models further identified that babysitting/childminding was associated with lower dementia risk in men (HR: 0.75, 95% CI: 0.56–0.99). No other social activities showed significant associations with dementia.

Discussion
This study provides evidence of social activities influencing dementia risk. Further investigations are required to uncover the mechanisms driving these observed relationships.
EryDB: A Transcriptomic Profile Database for Erythropoiesis and Erythroid-related Diseases
Authors: Zheng Guangmin , Wu Song , Zhang Zhaojun , Xin Zijuan , Zhang Lijuan , Zhao Siqi , Wu Jing , Liu Yanxia , Li Meng , Ruan Xiuyan , Qiao Nan , Bao Yiming , Qu Hongzhu , Fang Xiangdong 
Published: April 2024

Abstract
Erythropoiesis is a finely regulated and complex process that involves multiple transformations from hematopoietic stem cells to mature red blood cells at hematopoietic sites from the embryonic to the adult stages. Investigations into its molecular mechanisms have generated a wealth of expression data, including bulk and single-cell RNA sequencing data. A comprehensively integrated and well-curated erythropoiesis-specific database will greatly facilitate the mining of gene expression data and enable large-scale research of erythropoiesis and erythroid-related diseases. Here, we present EryDB, an open-access and comprehensive database dedicated to the collection, integration, analysis, and visualization of transcriptomic data for erythropoiesis and erythroid-related diseases. Currently, the database includes expertly curated quality-assured data of 3803 samples and 1,187,119 single cells derived from 107 public studies of three species (Homo sapiens, Mus musculus, and Danio rerio), nine tissue types, and five diseases. EryDB provides users with the ability to not only browse the molecular features of erythropoiesis between tissues and species, but also perform computational analyses of single-cell and bulk RNA sequencing data, thus serving as a convenient platform for customized queries and analyses. EryDB v1.0 is freely accessible at https://ngdc.cncb.ac.cn/EryDB/home.
The Time to Inflammatory Bowel Disease Diagnosis for Patients Presenting with Abdominal Symptoms in Primary Care and its Association with Emergency Hospital Admissions and Surgery: A Retrospective Cohort Study
Authors: Umar Nosheen , Harvey Phil , Adderley Nicola J , Haroon Shamil , Trudgill Nigel 
Published: April 2024

Abstract

Background
Patients with inflammatory bowel disease (IBD) presenting to primary care may experience diagnostic delays. We aimed to evaluate this and assess whether time to diagnosis is associated with clinical outcomes.

Methods
A retrospective cohort study using English primary care data from January 1, 2010, to December 31, 2019, linked to hospital admission data was undertaken. Patients were followed from the first IBD-related presentation in primary care to IBD diagnosis. Associations of time to diagnosis exceeding a year were assessed using a Robust Poisson regression model. Associations between time to diagnosis and IBD-related emergency hospital admissions and surgery were assessed using Poisson and Cox proportional hazards models, respectively.

Results
Of 28 092 IBD patients, 60% had ulcerative colitis (UC) and 40% had Crohn’s disease (CD). The median age was 43 (interquartile range, 30-58) years and 51.9% were female. Median time to diagnosis was 15.6 (interquartile range, 4.3-28.1) months. Factors associated with more than a year to diagnosis included female sex (adjusted risk ratio [aRR], 1.23; 95% CI, 1.21-1.26), older age (aRR, 1.05; 95% CI, 1.01-1.10; comparing &gt;70 years of age with 18-30 years of age), obesity (aRR, 1.03; 95% CI, 1.00-1.06), smoking (aRR, 1.05; 95% CI, 1.02-1.08), CD compared with UC (aRR, 1.13; 95% CI, 1.11-1.16), and a fecal calprotectin over 500 μg/g (aRR, 0.89; 95% CI, 0.82-0.95). The highest quartile of time to diagnosis compared with the lowest was associated with IBD-related emergency admissions (incidence rate ratio, 1.06; 95% CI, 1.01-1.11).

Conclusion
Longer times to IBD diagnoses were associated with being female, advanced age, obesity, smoking, and Crohn’s disease. More IBD-related emergency admissions were observed in patients with a prolonged time to diagnosis.
Three-dimensional printed pure-titanium implantation for chest wall reconstruction involving the sternum and ribs: a novel approach
Authors: Yoon Dong Woog , Kim Tae Ho , Cha Min Jae , Kim Gun-Hee , Lee ByoungSoo , Kim Hyung Giun , Kwon Minhyeok , Jang Donghoon , Park Byungjoon 
Published: April 2024

Abstract
Chest wall reconstruction is challenging due to the complex shape and large defect size. The three-dimensional printing technology enables the fabrication of customized implants, and 3D-printed pure-titanium could provide superior mechanical properties to conventional materials. The aim of this study was to evaluate long-term outcomes of patients undergoing chest wall reconstruction with a 3D-printed pure-titanium implant. Between August 2018 and May 2021, 5 patients underwent surgery due to sternal metastasis (n = 3), postoperative sternal wound infection (n = 1) and deformity (n = 1). The customized implant was designed and constructed based on the size and shape of the chest wall defect measured on computed tomography. All patients demonstrated uneventful recovery without complications during the hospital course. During the median follow-up of 20 months, 1 patient underwent revision surgery due to implant breakage, and 1 removed the implant due to trauma-related chest wall infection. One patient died from cancer progression, while 3 patients are alive without any implant-related complications. Chest wall reconstruction using a 3D-printed pure-titanium implant could be a novel alternative for patients with various conditions affecting the sternum and ribs.
Minimal Diffeomorphisms with L1 Hopf Differentials
Authors: Sagman Nathaniel 
Published: April 2024

Abstract
We prove that for any two Riemannian metrics $\sigma _{1}, \sigma _{2}$ on the unit disk, a homeomorphism $\partial \mathbb{D}\to \partial \mathbb{D}$ extends to at most one quasiconformal minimal diffeomorphism $(\mathbb{D},\sigma _{1})\to (\mathbb{D},\sigma _{2})$ with $L^{1}$ Hopf differential. For minimal Lagrangian diffeomorphisms between hyperbolic disks, the result is known, but this is the first proof that does not use anti-de Sitter geometry. We show that the result fails without the $L^{1}$ assumption in variable curvature. The key input for our proof is the uniqueness of solutions for a certain Plateau problem in a product of trees.
Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells
Authors: Kawakami Satoshi , Johmura Yoshikazu , Nakanishi Makoto 
Published: April 2024

Abstract
Senescent cells accumulate in various organs with ageing, and its accumulation induces chronic inflammation and age-related physiological dysfunctions. Several remodelling of intracellular environments have been identified in senescent cells, including enlargement of cell/nuclear size and intracellular acidification. Although these alterations of intracellular environments were reported to be involved in the unique characteristics of senescent cells, the contribution of intracellular acidification to senescence-associated cellular phenotypes is poorly understood. Here, we identified that the upregulation of TXNIP and its paralog ARRDC4 as a hallmark of intracellular acidification in addition to KGA-type GLS1. These genes were also upregulated in response to senescence-associated intracellular acidification. Neutralization of the intracellular acidic environment ameliorated not only senescence-related upregulation of TXNIP, ARRDC4 and KGA but also inflammation-related genes, possibly through suppression of PDK-dependent anaerobic glycolysis. Furthermore, we found that expression of the intracellular acidification-induced genes, TXNIP and ARRDC4, correlated with inflammatory gene expression in heterogeneous senescent cell population in vitro and even in vivo, implying that the contribution of intracellular pH to senescence-associated cellular features, such as SASP.
Muscle density, but not size, is independently associated with cognitive health in older adults with hip fractures
Authors: Ge Yufeng , You Qian , Gao Feng , Liu Gang , Wang Ling , Li Bo , Tian Maoyi , Yang Minghui , Wu Xinbao 
Published: April 2024

Abstract
Emerging evidence indicates a complex interplay between skeletal muscle and cognitive function. Despite the known differences between muscle quantity and quality, which can be measured via computed tomography (CT), the precise nature of their associations with cognitive performance remain underexplored. To investigate the links between muscle size and density and cognitive impairment (CI) in the older adults with hip fractures, we conducted a post hoc, cross-sectional analysis within a prospective cohort study on 679 patients with hip fractures over 65. Mini-Mental State Examination (MMSE) and routine hip CT imaging were utilized to assess cognition function and muscle characteristics in older adults with hip fractures. The CT scans provided data on cross-sectional area and attenuation for the gluteus maximus (G.MaxM) and the combined gluteus medius and minimus (G.Med/MinM). Participants were categorized into CI and non-CI groups based on education levels and MMSE scores. Multivariate logistic regressions, propensity score (PS) methods, and subgroup analysis were employed to analyze associations and validate findings. This study included 123 participants (81.6 ± 6.8 years, 74% female) with CI and 556 participants (78.5 ± 7.7 years, 72% female) without. Compared to the non-CI group, muscle parameters, especially density, were significantly lower in the CI group. Specifically, G.Med/Min muscle density, but not size was robustly associated with CI (odds ratio (OR) = 0.77, 95% confidence interval = 0.62–0.96, P = 0.02), independent of other medical situations. Sensitivity analysis corroborated that G.Med/Min muscle density was consistently lower in the CI group than the non-CI group, as evidenced in the PS matched (P = 0.024) and weighted cohort (P = 0.033). Enhanced muscle parameters, particularly muscle density in the G.Med/MinM muscle, correlate with a lower risk of CI. Muscle density demonstrates a stronger association with cognitive performance than muscle size, highlighting its potential as a key focus in future cognitive health research.
Pigeon pea crop stage strongly influences plant susceptibility to Helicoverpa armigera (Lepidoptera: Noctuidae)
Authors: Volp Trevor M , Zalucki Myron P , Furlong Michael J 
Published: April 2024

Abstract
Helicoverpa armigera Hübner (Lepidoptera: Noctuidae; Hübner) is the major insect pest of pigeon pea [Cajanus cajan; Fabales: Fabaceae; (L.) Millspaugh] worldwide. Research to develop pest management strategies for H. armigera in pigeon pea has focused heavily on developing less susceptible cultivars, with limited practical success. We examined how pigeon pea crop stage influences plant susceptibility to H. armigera using a combination of glasshouse and laboratory experiments. Plant phenology significantly affected oviposition with moths laying more eggs on flowering and podding plants but only a few on vegetative plants. Larval survival was greatest on flowering and vegetative plants, wherein larvae mostly chose to feed inside flowers on flowering plants and on the adaxial surface of expanding leaves on vegetative plants. Larval survival was poor on podding plants despite moths laying many eggs on plants of this stage. When left to feed without restriction on plants for 7 days, larvae feeding on flowering plants were &gt;10 times the weight of larvae feeding on plants of other phenological stages. On whole plants, unrestricted larvae preferred to feed on pigeon pea flowers and on expanding leaves, but in no-choice Petri dish assays H. armigera larvae could feed and survive on all pigeon pea reproductive structures. Our results show that crop stage and the availability of flowers strongly influence pigeon pea susceptibility to H. armigera. An increased understanding of H. armigera-pigeon pea ecology will be useful in guiding the development of resistant varieties and other management tactics.
A large cheek lipoma misdiagnosed as a dental infection: a rare case report
Authors: Hamamin Omed Shafiq , Abdulrahman Saman Wahid , Abdul Aziz Jeza M , Rashid Muhammad Jabar , Rasheed Mariwan Kadir , Najmalddin Lana Dara , Ahmad Kani Abdulrahman , Mohammed Baz Bakhtyar , Sleman Nida Khalid , Huy Nguyen Tien 
Published: April 2024

Abstract
The most frequent benign tumor is lipoma. About 1–4% of people have intraoral lipomas. This uncommon case report shows a large cheek lipoma misinterpreted as dental infection. A 14-year-old girl with a right cheek tumor was diagnosed and treated for a dental infection. Multiple imaging examinations complete the diagnosis. A benign lipoma, common in subcutaneous tissues but unusual in the mouth, created the lesion. A histological investigation confirmed lipoma after extraoral excision under general anesthesia utilizing an external flap. The edema did not return after surgery, which restored face symmetry. This case study shows that diagnosing and treating oral and maxillofacial edema requires extensive clinical and radiographic testing. Lipomas should be evaluated in the differential diagnosis of mouth swelling even without usual risk markers to prevent excessive treatments and delays. Surgery is recommended for lipomas since it has a low recurrence and fewer risks.
Management of ossifying fibroma of the bone of the maxilla: a case report and review of the literature
Authors: Nnko Kanankira A , Pima Raphael T , Damas Sosthenes , Mremi Alex 
Published: April 2024

Abstract
Ossifying fibroma (OF) is a slow-growing benign fibro-osseous neoplasm. It is mostly odontogenic in origin, and it arises in the jaws, particularly the mandible. OF is characterized by the production of bone and cementum-like calcifications in a fibrous stroma. OF reports of the bone of the maxilla are uncommon. Diagnosing OF can be challenging due to the considerable overlap of clinico-pathological characteristics with those of other neoplasms. Herein, the authors describe a case report OF in a 26-year-old male who presented with a huge fibro-osseous tumor of the maxilla. Histopathology established the diagnosis of maxillary OF. The tumor was surgically removed via a Weber–erguson approach with satisfactory functional and cosmetic results. No recurrence has been found after one year of follow-up. Clinical, radiological, and pathological characteristics, as well as surgical treatment approaches, are further discussed. This is one of a few documented cases of maxillary OF in our setting.
WFC3 Infrared Spectroscopic Parallel (WISP) survey: photometric and emission-line data release
Authors: Battisti A J , Bagley M B , Rafelski M , Baronchelli I , Dai Y S , Henry A L , Atek H , Colbert J , Malkan M A , McCarthy P J , Scarlata C , Siana B , Teplitz H I , Alavi A , Boyett K , Bunker A J , Gardner J P , Hathi N P , Masters D , Mehta V , Rutkowski M , Shahinyan K , Sunnquist B , Wang X 
Published: April 2024

ABSTRACT
We present reduced images and catalogues of photometric and emission-line data (∼230 000 and ∼8000 sources, respectively) for the WFC3 (Wide Field Camera 3) Infrared Spectroscopic Parallel (WISP) survey. These data are made publicly available on the Mikulski Archive for Space Telescopes and include reduced images from various facilities: ground-based ugri, Hubble Space Telescope (HST) WFC3, and Spitzer IRAC (Infrared Array Camera). Coverage in at least one additional filter beyond the WFC3/IR data are available for roughly half of the fields (227 out of 483), with ∼20 per cent (86) having coverage in six or more filters from u band to IRAC 3.6 $\mu$m (0.35–3.6 $\mu$m). For the lower spatial resolution (and shallower) ground-based and IRAC data, we perform PSF (point spread function)-matched, prior-based, deconfusion photometry (i.e. forced-photometry) using the tphot software to optimally extract measurements or upper limits. We present the methodology and software used for the WISP emission-line detection and visual inspection. The former adopts a continuous wavelet transformation that significantly reduces the number of spurious sources as candidates before the visual inspection stage. We combine both WISP catalogues and perform spectral energy distribution fitting on galaxies with reliable spectroscopic redshifts and multiband photometry to measure their stellar masses. We stack WISP spectra as functions of stellar mass and redshift and measure average emission-line fluxes and ratios. We find that WISP emission-line sources are typically ‘normal’ star-forming galaxies based on the mass–excitation diagram ([O iii]/Hβ versus M⋆; 0.74 &lt; zgrism &lt; 2.31), the galaxy main sequence (SFR versus M⋆; 0.30 &lt; zgrism &lt; 1.45), S32 ratio versus M⋆ (0.30 &lt; zgrism &lt; 0.73), and O32 and R23 ratios versus M⋆ (1.27 &lt; zgrism &lt; 1.45).
Robust inference of the Galactic Centre gamma-ray excess spatial properties
Authors: Song Deheng , Eckner Christopher , Gordon Chris , Calore Francesca , Macias Oscar , Abazajian Kevork N , Horiuchi Shunsaku , Kaplinghat Manoj , Pohl Martin 
Published: April 2024

ABSTRACT
The gamma-ray Fermi-LAT Galactic Centre excess (GCE) has puzzled scientists for over 15 yr. Despite ongoing debates about its properties, and especially its spatial distribution, its nature remains elusive. We scrutinize how the estimated spatial morphology of this excess depends on models for the Galactic diffuse emission, focusing particularly on the extent to which the Galactic plane and point sources are masked. Our main aim is to compare a spherically symmetric morphology – potentially arising from the annihilation of dark matter (DM) particles – with a boxy morphology – expected if faint unresolved sources in the Galactic bulge dominate the excess emission. Recent claims favouring a DM-motivated template for the GCE are shown to rely on a specific Galactic bulge template, which performs worse than other templates for the Galactic bulge. We find that a non-parametric model of the Galactic bulge derived from the VISTA Variables in the Via Lactea survey results in a significantly better fit for the GCE than DM-motivated templates. This result is independent of whether a galprop-based model or a more non-parametric ring-based model is used to describe the diffuse Galactic emission. This conclusion remains true even when additional freedom is added in the background models, allowing for non-parametric modulation of the model components and substantially improving the fit quality. When adopted, optimized background models provide robust results in terms of preference for a boxy bulge morphology for the GCE, regardless of the mask applied to the Galactic plane.
Risk factors for serious infections and infection-related mortality in patients with microscopic polyangiitis: Multicentre REVEAL cohort study
Authors: Manabe Atsushi , Kadoba Keiichiro , Hiwa Ryosuke , Kotani Takuya , Shoji Mikihito , Shirakashi Mirei , Tsuji Hideaki , Kitagori Koji , Akizuki Shuji , Nakashima Ran , Yoshifuji Hajime , Yamamoto Wataru , Okazaki Ayana , Matsuda Shogo , Gon Takaho , Watanabe Ryu , Hashimoto Motomu , Morinobu Akio 
Published: April 2024

ABSTRACT

Objective
Infections are a critical concern for patients with microscopic polyangiitis (MPA). This study aimed to identify the risk factors associated with serious infections (SIs) and infection-related mortality in patients with MPA, as well as the effect of glucocorticoid (GC) dose tapering on these outcomes.

Methods
This multicentre, retrospective, and observational study utilised data from a cohort of patients with MPA in Japan [Registry of Vasculitis Patients to Establish REAL World Evidence (REVEAL) cohort]. Patients were categorised based on the occurrence of SIs or infection-related deaths, and various characteristics were compared among the groups.

Results
Among 182 patients, 66 (36.2%) experienced 129 SIs and 27 (14.8%) developed infection-related deaths. Advanced age, elevated C-reactive protein (CRP) levels, and higher ratio of the GC dose at 3 months to the initial dose were identified as independent risk factors for SIs. Older age was also associated with infection-related deaths. Furthermore, the cumulative incidence of infection-related deaths was significantly higher in patients with a higher ratio of the GC dose at 24 months to the initial dose.

Conclusion
Older age, elevated CRP levels, and slower GC dose tapering predispose patients to SIs and infection-related deaths. Strategies, such as rapid GC dose tapering, are anticipated to mitigate the risk of infections.