bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extremophile hypolithic communities in the Vestfold Hills, East Antarctica
Authors: Clarke Laurence J. , Raes Eric J. , Travers Toby , Virtue Patti , Bergstrom Dana M. 
Published: March 2024

AbstractThe Vestfold Hills are a 400 km2, isolated ice-free oasis in eastern Antarctica featuring large areas with translucent quartz rocks that provide habitat for hypolithic microbial communities underneath. We used high-throughput DNA sequencing of 16S and 18S ribosomal RNA amplicons to characterize bacterial and eukaryotic hypolithic communities across the Vestfold Hills. We found high-level, local heterogeneity in community structure consistent with limited dispersal between hypoliths. Hypolithic communities were dominated by heterotrophic Bacteroidetes (mean bacterial relative read abundance: 56%) as well as Cyanobacteria (35%), with the eukaryote component often dominated by Chlorophyta (43%). Small but significant proportions of the variation in microbial community composition and function were explained by soil salinity (5–7%) and water availability (8–11%), with distinct taxa associated with different salinities and water availabilities. Furthermore, many inferred bacterial metabolic pathways were enriched in hypolithic communities from either dry or high-salinity sites. Vestfold Hills hypolithic habitats are likely to be local refuges for bacterial and eukaryotic diversity. Gradients in soil salinity and water availability across the Vestfold Hills, in addition to the number and diversity of lake types and fjords as potential source populations, may contribute to the observed variation in the extremophile, hypolithic microbial community composition.
Secondary Ambulance Transfers During the Mass-Casualty Terrorist Attack in Israel on October 7, 2023
Authors: Alpert Evan Avraham , Assaf Jacob , Nama Ahmad , Pliner Ruchama , Jaffe Eli 
Published: March 2024

AbstractOn October 7, 2023, Israel experienced the worst terror attack in its history – 1,200 people were killed, 239 people were taken hostage, and 1,455 people were wounded. This mass-casualty event (MCE) was more specifically a mega terrorist attack. Due to the overwhelming number of victims who arrived at the two closest hospitals, it became necessary to implement secondary transfers to centers in other areas of the country. Historically, secondary transfer has been implemented in MCEs but usually for the transfer of critical patients from a Level 2 or Level 3 Trauma Center to a Level 1 Center. Magen David Adom (MDA), Israel’s National Emergency Pre-Hospital Medical Organization, is designated by the Health Ministry as the incident command at any MCE. On October 7, in addition to the primary transport of victims by ambulance to hospitals throughout Israel, they secondarily transported patients from the two closest hospitals – the Soroka Medical Center (SMC; Level 1 Trauma Center) in Beersheba and the Barzilai Medical Center (BMC; Level 2 Trauma Center) in Ashkelon. Secondary transport began five hours after the event started and continued for approximately 12 hours. During this time, the terrorist infiltration was still on-going. Soroka received 650 victims and secondarily transferred 26, including five in Advanced Life Support (ALS) ambulances. Barzilai received 372 and secondarily transferred 38. These coordinated secondary transfers helped relieve the overwhelmed primary hospitals and are an essential component of any MCE strategy.
An investigation of the experience of control through the sense of agency in people with obsessive–compulsive disorder: a review and meta-analysis
Authors: Borrelli Davide Fausto , Tonna Matteo , Dar Reuven 
Published: March 2024

AbstractThe construct of sense of agency (SoA) has proven useful for understanding mechanisms underlying obsessive–compulsive disorder (OCD) phenomenology, especially in explaining the apparent dissociation in OCD between actual and perceived control over one’s actions. Paradoxically, people with OCD appear to experience both diminished SoA (feeling unable to control their actions) and inflated SoA (having “magical” control over events). The present review investigated the extent to which the SoA is distorted in OCD, in terms of both implicit (ie, inferred from correlates and outcomes of voluntary actions) and explicit (ie, subjective judgment of one’s control over an outcome) measures of SoA. Our search resulted in 15 studies that met the criteria for inclusion in a meta-analysis, where we also examined the potential moderating effects of the type of measure (explicit versus implicit) and of the actual control participants had over the outcome. We found that participants with OCD or with high levels of OCD symptoms show lower implicit measures of SoA and at the same time tend to overestimate their control in situations where they do not actually have it. Together, these findings support the hypothesized dissociation in OCD between actual and perceived control over one’s actions.
Trajectory and magnitude of response in adults with anxiety disorders: a Bayesian hierarchical modeling meta-analysis of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and benzodiazepines
Authors: Mendez Eric M. , Mills Jeffrey A. , Suresh Vikram , Stimpfl Julia N. , Strawn Jeffrey R. 
Published: March 2024

AbstractBackgroundHow the trajectory of response to medication (and placebo response) varies among selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), benzodiazepines and across anxiety disorders is unknown.MethodsWe performed a meta-analysis using weekly symptom severity data from randomized, parallel-group, placebo-controlled trials of SSRIs, SNRIs, and benzodiazepines in adults with anxiety disorders. Response was modeled for the standardized change in anxiety using Bayesian hierarchical models.ResultsAcross 122 trials (N=15,760), SSRIs, SNRIs, and benzodiazepines produced significant improvement in anxiety compared to placebo. Benzodiazepines produced faster improvement by the first week of treatment (p < 0.001). By week 8, the response for benzodiazepines and SSRIs (p = 0.103) and SNRIs (p = 0.911) did not differ nor did SSRIs and SNRIs differ (p = 0.057), although for patients with generalized anxiety disorder (GAD), the benzodiazepines produced greater improvement than SNRIs at week 8 (difference − 12.42, CrI: −25.05 to −0.78, p = 0.037). Medication response was similar across anxiety disorders except for benzodiazepines, which produced greater improvement over the first 4 weeks compared to SSRIs and SNRIs in panic disorder. For SSRIs and SNRIs, women improved more than men, and for benzodiazepines, older patients improved more compared to younger patients. Finally, placebo response plateaued by week 4 of treatment, and, at week 8, social anxiety disorder trials had lower placebo response compared to other anxiety disorders.ConclusionsBenzodiazepines show early improvement compared to SSRIs and SNRIs. However, by week 8, all treatments yield similar results. Patient characteristics influence the improvement trajectory and magnitude, suggesting potential for personalized medication selection.
Reversal of Projected European Summer Precipitation Decline in a Stabilizing Climate
Authors: Dittus A. J. , Collins M. , Sutton R. , Hawkins E. 
Published: March 2024

AbstractPrecipitation projections in transient climate change scenarios have been extensively studied over multiple climate model generations. Although these simulations have also been used to make projections at specific Global Warming Levels (GWLs), dedicated simulations are more appropriate to study changes in a stabilizing climate. Here, we analyze precipitation projections in six multi‐century experiments with fixed atmospheric concentrations of greenhouse gases, conducted with the UK Earth System Model and which span a range of GWLs between 1.5 and 5°C of warming. Regions are identified where the sign of precipitation trends in high‐emission transient projections is reversed in the stabilization experiments. For example, stabilization reverses a summertime precipitation decline across Europe. This precipitation recovery occurs concurrently with changes in the pattern of Atlantic sea surface temperature trends due to a slow recovery of the Atlantic Meridional Overturning Circulation in the stabilization experiments, along with changes in humidity and atmospheric circulation.
A Combined Effect of the Earth's Magnetic Dipole Tilt and IMF By in Controlling Auroral Electron Precipitation
Authors: Laitinen J. , Holappa L. , Vanhamäki H. 
Published: March 2024

AbstractAuroral particle precipitation is usually assumed to be equally strong for both signs of the By component of the interplanetary magnetic field (IMF). This is also the case in most currently used precipitation models, which parameterize solar wind driving by empirical coupling functions. However, recent studies have showed that geomagnetic activity is significantly modulated by the signs and amplitudes of IMF By and the Earth's dipole tilt angle Ψ. This so called explicit By dependence is not yet included in any current precipitation models. In this paper, we quantify this By dependence for auroral electron precipitation for the first time. We use precipitation measurements of the Defense Meteorological Satellite Program (DMSP) Special Sensor J instruments from years 1995–2022. We show that the dawnside electron precipitation at energies 13.9–30 keV is greater at auroral latitudes for opposite signs of By and Ψ in both hemispheres, while the dusk sector is mostly unaffected by By and Ψ. For energies below 6.5 keV the By dependence is strong poleward of the auroral oval in the summer hemisphere, also exhibiting a strong dawn‐dusk asymmetry. We also show that By dependence of precipitation modulates ionospheric conductance.
Stochastic in Space and Time: 2. Effects of Simulating Orographic Gradients in Daily Runoff Variability on Bedrock River Incision
Authors: Forte A. M. , Rossi M. W. 
Published: March 2024

AbstractThe extent to which climate and tectonics can be coupled rests on the degree to which topography and erosion rates scales linearly. The stream power incision model (SPIM) is commonly used to interpret such relationships, but is limited in probing mechanisms. A promising modification to stream power models are stochastic‐threshold incision models (STIM) which incorporate both variability in discharge and a threshold to erosion. In this family of models, the form of the topography erosion rate relationship is largely controlled by runoff variability. Applications of STIM typically assume temporally variable, but spatially uniform and synchronous runoff generating events, an assumption that is likely broken in regions with complicated orography. To address this limitation, we develop a new 1D STIM model, which we refer to as spatial‐STIM. This modified version of STIM allows for stochasticity in both time and space and is driven by empirical relationships between topography and runoff statistics. Coupling between mean runoff and runoff variability via topography in spatial‐STIM generates highly nonlinear relationships between steady‐state topography and erosion rates. We find that whether the daily statistics of runoff are spatially linked or unlinked, which sets whether there is spatial synchronicity in the recurrence interval of runoff generating events, is a fundamental control on landscape evolution. Many empirical topography—erosion rate data sets are based on data that span across the endmember scenarios of linked versus unlinked behavior. It is thus questionable whether singular SPIM relationships fit to those data can be meaningfully related to their associated hydroclimatic conditions.
Urban Ecohydrology: Accounting for Sub‐Grid Lateral Water and Energy Transfers in a Land Surface Model
Authors: Alexander G. Aaron , Voter Carolyn B. , Wright Daniel B. , Loheide Steven P. 
Published: March 2024

AbstractAlthough urbanization fundamentally alters water and energy cycles, contemporary land surface models (LSMs) often do not include key urban vegetation processes that serve to transfer water and energy laterally across heterogeneous urban land types. Urban water/energy transfers occur when rainfall landing on rooftops, sidewalks, and driveways is redirected to lawns or pervious pavement and when transpiration occurs from branches overhanging impervious surfaces with the corresponding root water uptake takes place in nearby portions of yards. We introduce Noah‐MP for Heterogenous Urban Environments (Noah‐MP HUE), which adds sub‐grid water transfers to the widely used Noah‐MP LSM. We examine how sub‐grid water transfers change surface water and energy balances by systematically increasing the amount of simulated water transfer for four scenarios: tree canopy expanding over pavement (Urban Tree Expansion), tree canopy shifting over pavement (Urban Tree Shift), and directing impermeable runoff onto surrounding vegetation (Downspout Disconnection) or into an engineered pavement (Permeable Pavement). Even small percentages of sub‐grid water transfer can reduce runoff and enhance evapotranspiration and deep drainage. Event‐scale runoff reduction depends on storm depth, rainfall intensity, and antecedent soil moisture. Sub‐grid water transfers also tend to enhance (reduce) latent (sensible) heat. Results highlight the importance not only of fine‐scale heterogeneity on larger scale surface processes, but also the importance of urban management practices that enhance lateral water transfers and water storage–so‐called green infrastructure–as they change land surface fluxes and, potentially, atmospheric processes. This work opens a pathway to directly integrate those practices in regional climate simulations.
Nanofabricated high turn-density spiral coils for on-chip electromagneto-optical conversion
Authors: Bok Ilhan , Ashtiani Alireza , Gokhale Yash , Phillips Jack , Zhu Tianxiang , Hai Aviad 
Published: March 2024

AbstractCircuit-integrated electromagnets are fundamental building blocks for on-chip signal transduction, modulation, and tunability, with specific applications in environmental and biomedical micromagnetometry. A primary challenge for improving performance is pushing quality limitations while minimizing size and fabrication complexity and retaining spatial capabilities. Recent efforts have exploited highly involved three-dimensional synthesis, advanced insulation, and exotic material compositions. Here, we present a rapid nanofabrication process that employs electron beam dose control for high-turn-density diamond-embedded flat spiral coils; these coils achieve efficient on-chip electromagnetic-to-optical signal conversion. Our fabrication process relies on fast 12.3 s direct writing on standard poly(methyl methacrylate) as a basis for the metal lift-off process. Prototypes with 70 micrometer overall diameters and 49–470 nm interturn spacings with corresponding inductances of 12.3–12.8 nH are developed. We utilize optical micromagnetometry to demonstrate that magnetic field generation at the center of the structure effectively correlates with finite element modeling predictions. Further designs based on our process can be integrated with photolithography to broadly enable optical magnetic sensing and spin-based computation.
First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study
Authors: Chen Xiaofeng , Xu Hao , Chen Xiaobing , Xu Tongpeng , Tian Yitong , Wang Deqiang , Guo Fen , Wang Kangxin , Jin Guangfu , Li Xiao , Wang Rong , Li Fengyuan , Ding Yongbin , Tang Jie , Fang Yueyu , Zhao Jing , Liu Liang , Ma Ling , Meng Lijuan , Hou Zhiguo , Zheng Rongrong , Liu Yang , Guan Ni , Zhang Bei , Tong Shuang , Chen Shiqing , Li Xing , Shu Yongqian 
Published: March 2024

AbstractPatients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapy for advanced gastric or gastroesophageal junction adenocarcinoma. The primary endpoints included maximum tolerated dose (MTD) in phase 1a and objective response rate (ORR) across phase 1a and 1b. Phase 1a tested three dose regimens of camrelizumab, apatinib, oxaliplatin, and S-1. Dose regimen 1: camrelizumab 200 mg on day 1, apatinib 250 mg every other day, oxaliplatin 100 mg/m² on day 1, and S-1 40 mg twice a day on days 1–14. Dose regimen 2: same as dose regimen 1, but oxaliplatin 130 mg/m². Dose regimen 3: same as dose regimen 2, but apatinib 250 mg daily. Thirty-four patients were included (9 in phase 1a, 25 in phase 1b). No dose-limiting toxicities occurred so no MTD was identified. Dose 3 was set for the recommended phase 2 doses and administered in phase 1b. The confirmed ORR was 76.5% (95% CI 58.8–89.3). The median progression-free survival was 8.4 months (95% CI 5.9-not evaluable [NE]), and the median overall survival (OS) was not mature (11.6-NE). Ten patients underwent surgery after treatment and the multidisciplinary team evaluation. Among 24 patients without surgery, the median OS was 19.6 months (7.8-NE). Eighteen patients (52.9%) developed grade ≥ 3 treatment-emergent adverse events. Camrelizumab plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer (ChiCTR2000034109).
Understanding flash flooding in the Himalayan Region: a case study
Authors: Nagamani Katukotta , Mishra Anoop Kumar , Meer Mohammad Suhail , Das Jayanta 
Published: March 2024

AbstractThe Himalayan region, characterized by its substantial topographical scale and elevation, exhibits vulnerability to flash floods and landslides induced by natural and anthropogenic influences. The study focuses on the Himalayan region, emphasizing the pivotal role of geographical and atmospheric parameters in flash flood occurrences. Specifically, the investigation delves into the intricate interactions between atmospheric and surface parameters to elucidate their collective contribution to flash flooding within the Nainital region of Uttarakhand in the Himalayan terrain. Pre-flood parameters, including total aerosol optical depth, cloud cover thickness, and total precipitable water vapor, were systematically analyzed, revealing a noteworthy correlation with flash flooding event transpiring on October 17th, 18th, and 19th, 2021. Which resulted in a huge loss of life and property in the study area. Contrasting the October 2021 heavy rainfall with the time series data (2000–2021), the historical pattern indicates flash flooding predominantly during June to September. The rare occurrence of October flash flooding suggests a potential shift in the area's precipitation pattern, possibly influenced by climate change. Robust statistical analyses, specifically employing non-parametric tests including the Autocorrelation function (ACF), Mann–Kendall (MK) test, Modified Mann–Kendall, and Sen's slope (q) estimator, were applied to discern extreme precipitation characteristics from 2000 to 201. The findings revealed a general non-significant increasing trend, except for July, which exhibited a non-significant decreasing trend. Moreover, the results elucidate the application of Meteosat-8 data and remote sensing applications to analyze flash flood dynamics. Furthermore, the research extensively explores the substantial roles played by pre and post-atmospheric parameters with geographic parameters in heavy rainfall events that resulted flash flooding, presenting a comprehensive discussion. The findings describe the role of real time remote sensing and satellite and underscore the need for comprehensive approaches to tackle flash flooding, including mitigation. The study also highlights the significance of monitoring weather patterns and rainfall trends to improve disaster preparedness and minimize the impact of flash floods in the Himalayan region.
The characteristics and risk factors of fatal falls among adults aged 60 and above in Southwest China
Authors: Deng Rui , Li Benyan , Qin Mingfang , Yu Xinyi , Sun Junli , Jiao Feng , Huang Yuan 
Published: March 2024

AbstractFalls constitute a leading cause of unintentional injury deaths among older adults. This study aimed to examine the comprehensive characteristics of fatal falls among older individuals in Yunnan Province, China, to highlight the challenges faced in elderly care. A total of 22,798 accidental fall-related deaths were extracted from China's National Disease Surveillance Points System aged 60 and above between 2015 and 2019. Quantitative and textual data were analyzed to assess the incidence rates of initiating factors, locations, symptoms, and overall survival (OS) outcomes after falling. Hypertension emerged as the most significant intrinsic factor, especially among individuals aged between 70 and 79, female older adults, and urban residents (P < 0.001). Home was identified as the most common location where fatal falls occurred (61.19%). The head was the most commonly injured body region (58.75%). The median of OS for all fatal falls was 2 days (0.13, 30), of which deaths occurred within 24 h [9287 (49.36%)]. There were instances where timely discovery after falling did not occur in 625 cases; their median of OS was significantly shorter compared to those discovered promptly after falling (P < 0.001). Targeted interventions focusing on fall prevention and post-fall care are equally crucial for the well-being of older adults.
Fungal and bacterial species richness in biodeteriorated seventeenth century Venetian manuscripts
Authors: Stratigaki Maria , Armirotti Andrea , Ottonello Giuliana , Manente Sabrina , Traviglia Arianna 
Published: March 2024

AbstractHistorical paper documents are susceptible to complex degradation processes, including biodeterioration, which can progressively compromise their aesthetic and structural integrity. This study analyses seventeenth century handwritten historical letters stored at the Correr Museum Library in Venice, Italy, exhibiting pronounced signs of biodeterioration. The techniques used encompassed traditional colony isolation on agar plates and proteomics analyses, employing nanoscale liquid chromatography coupled with high-resolution mass spectrometry (nano-LC–MS). Fluorescence microscopy was used for the first time in the historical paper biodeterioration context to supplement the conventional stereoscopic, optical, and scanning electron microscopic imaging techniques. This method enables the visualisation of microorganisms beyond and beneath the paper’s surface through their natural intrinsic autofluorescence in a non-invasive and non-destructive way. The results demonstrate a diverse, complex, and abundant microbiota composed of coexisting fungal and bacterial species (Ascomycota, Mucoromycota, Basidiomycota, Proteobacteria, and Actinobacteria), along with mite carcasses, insects, parasites, and possibly protists. Furthermore, this study reveals certain species that were not previously documented in the biodeterioration of historical paper, including human pathogens, such as Histoplasma capsulatum, Brucella, Candida albicans, and species of Aspergillus (A. flavus, A. fumigatus, A. oryzae, A. terreus, A. niger) known to cause infections or produce mycotoxins, posing substantial risk to both artefacts and humans.