bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hand flexor tenosynovitis in rheumatoid arthritis
Authors: Gray Robert G. , Gottlieb Norman L. 
Published: February 2007

AbstractTenosynovitis of one or more flexor tendons of the hand (mean 3.1 tendons per patient) was noted in 55% of 100 patients with rheumatoid arthritis (RA) examined periodically during a mean period of 5 years. The third flexor tendon was involved most frequently (71% of patients), followed by the second (62%), fourth (53%), fifth (27%), and first (13%). Patients with flexor tendonitis (FT) had a significantly higher prevalence of rheumatoid nodules (56% vs 33%), carpal tunnel syndrome (47% vs 13%), wrist extensor tenosynovitis (47% vs 9%), and elbow epicondylitis (22% vs 7%) than patients without FT. Dupuytren's contracture, DeQuervain's tenovaginitis, flexor carpi radialis and ulnaris tendonitis, and Achilles tendonitis were found exclusively in patients with FT. A control group of 50 non‐RA patients with FT had statistically fewer diseased tendons per patient (mean 1.5) and a different digital distribution, the thumb being affected more frequently (P < 0.05) than in RA patients.
C‐Reactive Protein in Systemic Lupus Erythematosus
Authors: Honig Stephen , Gorevic Peter , Weissmann Gerald 
Published: February 2007

AbstractThe presence of C‐reactive protein (CRP) was determined in the sera of 70 patients with systemic lupus erythematosus (SLE), 24 patients with rheumatoid arthritis (RA), and 17 patients hospitalized with acute infections. CRP (precipitin reaction > 3 mm) was present in only 2 of 50 patients with active, uncomplicated SLE (4%). However CRP was found in the sera of 11 patients with active SLE in the presence of superimposed infection. Treatment of the intercurrent infection resulted in the loss of CRP from the sera of these SLE patients. CRP was found in 85% of patients with active RA and in 100% of non‐SLE infected patients. Appropriate treatment of the latter group resulted in loss of CRP from the convalescent sera. Corticosteroid therapy did not appear to influence the presence of CRP in the RA or SLE groups. Fourteen of 50 noninfected patients (28%) with active SLE were not receiving steroids at the time of CRP negativity. Appropriate experiments with mixed sera failed to demonstrate serum factors that could influence CRP precipitation in the CRP‐negative SLE group. These studies suggest that patients with active SLE usually do not have CRP in their sera, and the results distinguish this group of patients from those with active RA, a disease generally marked by CRP positivity. Moreover, the finding of significant CRP precipitin in the sera of SLE patients may suggest the presence of superimposed infection.
Plant Thorn Synovitis
Authors: Sugarman Michael , Stobie Dennis G. , Quismorio Francisco P. , Terry Roger , Hanson Virgil 
Published: February 2007

AbstractFive children with an inflammatory monarthritis due to penetration of the joint by plant thorns are presented. The clinical presentation was that of a transient acute synovitis followed by a relatively asymptomatic period, and later by chronic arthritis often after the thorn injury was forgotten. Histopathology demonstrated a granulomatous synovitis. Polarized light microscopy facilitated identification of the plant tissue within the synovium. Conservative medical therapy was ineffective, but surgical excision of the affected synovium resulted in normal joint function. The differential diagnosis of monarthritis in children is extensive, and awareness of this condition is necessary to elicit a comprehensive history and to avoid delay in treatment.
Idiopathic or Traumatic Olecranon Bursitis
Authors: Canoso Juan J. 
Published: February 2007

AbstractThirty cases of idiopathic olecranon bursitis were studied. Most had previous local trauma. The process was unilateral and often associated with nontender pitting edema in cases of short duration. Ten patients exhibited a bony spur at the olecranon process, and amorphous calcific deposits were seen in 6. The bursal fluid was hemorrhagic with a xanthochromic supernatant, and the mucin clot test was poor or fair. Leukocyte count averaged 878/mm3, predominantly mononuclears. Many cells contained inclusion bodies. Glucose, total protein, and complement (C3) concentration averaged 80, 60, and 60% of the respective serum values.
Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint
Authors: Woolley David E. , Crossley Malcolm J. , Evanson John M. 
Published: February 2007

AbstractImmunolocalization studies of rheumatoid tissues employing specific synovial collagenase antibody have demonstrated immunoreactive enzyme at the cartilage/pannus junction. Collagenase was not detected in chondrocytes or the cartilage matrix remote from the resorbing front, and relatively little enzyme was observed in the hypertrophied synovial membrane itself. These observations directly support the idea that synovial collagenase participates in cartilage erosion in rheumatoid arthritis.
Experimental Radiation Synovectomy by 165Dy Ferric Hydroxide Macroaggregate
Authors: Sledge Clement B. , Noble Jonathan , Hnatowich Donald J. , Kramer Richard , Shortkroff Sonya 
Published: February 2007

AbstractThe short half—life beta emitter 165Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen—induced arthritic rabbit. Using 153Gd as a gamma tracer for leakage studies revealed that the leakage of this system from rabbit knee joints never exceeded 1.2% over 24 hours. This is much less than the leakage rates reported from any human studies or our rabbit studies using 198Au.
Patellar Whiskers and Acute Calcific Quadriceps Tendinitis in a General Hospital Population
Authors: Trujeque L. , Spohn P. , Bankhurst Arthur D. , Messner R. , Searles R. 
Published: February 2007

AbstractDescribed is a case of acute calcific quadriceps tendinitis which presented as monoarticular arthritis. A survey of general hospital patients revealed a 7% incidence of calcification of the superior patellar tendon. The most common concurrent abnormality was degenerative joint disease (94%); concomitant chondrocalcinosis was not seen. The “patellar whisker” is a relatively common x‐ray finding that may be the clue to an uncommon cause of acute arthritis.
Prostaglandin e1 treatment of NZB/NZW F1 hybrid MICE
Authors: Zurier Robert B. , Damjanov Ivan , Sayadoff Donna M. , Rothfield Naomi F. 
Published: February 2007

AbstractThe F1 hybrid of New Zealand black and New Zealand white mice—the NZB/NZW mouse—spontaneously develops a disease similar to human systemic lupus erythematous, characterized by impaired cell‐mediated and enhanced humoral immune responses, development of antibodies to nuclear antigens, and immune complex glomerulonephritis. Because there is experimental evidence that prostaglandin E1 (PGE1) can enhance T‐cell function and cell‐mediated responses and suppress B‐cell activity, NZB/NZW mice were treated with 200 μg PGE1 subcutaneously once or twice daily from 6 weeks of age. PGE1 treatment of female and male mice prevents glomerular deposition of immunoglobulins and complement (monitored by immunofluorescence), and development of the proliferative glomerulonephritis (determined by light and electron microscopy) characteristic of untreated NZB/NZW mice. After 1 year of treatment, 18 of 19 female mice survived, whereas only 2 of 19 untreated control mice were alive. Male mice treated with 200 μg PGE1 daily were also protected: 9 of 11 versus 2 of 9 untreated mice were alive at 65 weeks. PGE1 treatment did not prevent development of antibodies to nuclear material in any of the treated groups.
Antibodies to cytoplasmic antigens in lupus erythematosus
Authors: Provost Thomas T. , Razzaque Ahmed A. , Maddison Peter J. , Reichlin Morris 
Published: February 2007

AbstractSeven patients with classic cutaneous lupus ery‐thematosus are described. Three of these patients had features satisfying four of the American Rheumatism Association (ARA) preliminary criteria for the diagnosis of systemic lupus erythematosus (SLE). Their sera, however, lacked antinuclear antibodies but demonstrated precipitating antibodies reactive against cytoplasmic RNP (La) and non‐nucleic acid (Ro) antigens. Four additional ANA‐negative patients lacking significant skin disease but having a lupus‐like multisystem disease were found to have antibodies to soluble cytoplasmic antigens. Thirty‐three of 130 ANA‐positive SLE patients, but none of 16 discoid lupus patients, possessed these anticytoplasmic antibodies. These findings suggest that antibodies to Ro and La may be a marker for systemic disease in ANA‐negative patients with 1) cutaneous lupus and 2) a distinct sub‐population of patients with a lupus‐like syndrome without skin disease.
Clinical evaluation of D‐penicillamine by multicentric double‐blind comparative study in chronic rheumatoid arthritis
Authors: Shiokawa Yuichi , Horiuchi Yoshihiko , Honma Mitsuo , Kageyama Takamasa , Okada Takao , Azuma Takeshi 
Published: February 2007

AbstractIn order to evaluate clinical efficacy of D‐penicillamine (DP) a double‐blind study was conducted by the Metalcaptase Research Group consisting of forty‐one rheumatological centers in Japan. A total of 179 patients with rheumatoid arthritis (RA) was divided into two groups; one treated with 5 mg (control group) and the other with 100 mg (drug group) of DP in capsule form. The trial lasted 24 weeks. Global judgment by physicians revealed that improvement was found in 27% in the controls and 65% in the drug group. Adverse reactions occurred in 34% of the controls and 49% of the drug group. Skin rashes, taste disturbances, gastrointestinal upset and proteinuria were frequent in the drug group, but severe or fatal reactions could not be seen in this trial.
A double‐blind trial of high versus conventional dosages of gold salts for rheumatoid arthritis
Authors: Furst D. E. , Levine S. , Srinivasan R. , Metzger A. L. , Bangert R. , Paulus H. E. 
Published: February 2007

AbstractIn a double‐blind study, patients were randomly selected for treatment using conventional doses (CD; 50 mg) or high doses (HD; 150 mg) of sodium aurothiomalate given weekly by injection. Twenty‐three patients were assigned to the CD group and 24 to the HD group. Neither efficacy nor toxicity correlated with serum gold concentrations. Conventional doses were as efficacious as high doses with respect to both rapidity and degree of response. However, side effects were much more frequent and severe in the HD group. Thus there is no reason to recommend a 150 mg weekly dosage regimen.
Severe systemic lupus erythematosus with nephritis in a boy with deficiency of the fourth component of complement
Authors: Schaller Jane G. , Gilliland Bruce G. , Ochs Hans D. , Leddy John P. , Agodoa Lawrence C. Y. , Rosenfeld Stephen I. 
Published: February 2007

AbstractA young boy with severe systemic lupus erythematosus was found to be totally deficient in the fourth component of complement. Family studies were consistent with an autosomal recessive mode of transmission and with linkage of the gene(s) determining C4 deficiency to the major histocompatibility complex; no disease states were associated with heterozygosity. This patient has had severe multisystem disease and immune complex glomer‐ulonephritis; presumably the alternative pathway of complement was utilized in the pathogenesis of his nephritis.
Radiographic abnormalities of rheumatoid arthritis in patients with diffuse idiopathic skeletal hyperostosis
Authors: Resnick Donald , Curd John , Shapiro Robert F. , Wiesner Kenneth B. 
Published: February 2007

AbstractRadiographic abnormalities of rheumatoid arthritis (RA) in 8 patients with diffuse idiopathic skeletal hyperostosis (DISH) included atypical features: lack of osteoporosis, bone sclerosis and proliferation about erosions, osteophytosis, and bony ankylosis. Atypical clinical features included a high incidence of flexion contractures of elbows, wrists, ankles, or knees. It is not surprising that bone production occurs about involved articulations in patients with RA·DISH, as the latter disorder is characterized by bony proliferation at sites of ligament and tendon attachment to bone in the axial and extraaxial skeleton, perhaps related to stress.
Comparative studies of antilymphocyte, antipolynucleotide, and antiviral antibodies among families of patients with systemic lupus erythematosus
Authors: Folomeeva O. , Nassonova V. A. , Alekberova A. S. , Talal N. , Williams R. C. 
Published: February 2007

AbstractAntilymphocyte, antipolynucleotide, and antiviral antibodies in 15 Soviet systemic lupus erythematosus (SLE) probands and their 41 relatives were compared with those in 57 members of 15 control Russian families. Seventy‐eight and three‐tenths percent of SLE relatives were positive for antilymphocyte antibody versus 26.3% positive reactions in controls. Antipolynucleotide antibody closely paralleled antilymphocyte antibody in both groups. Antiviral antibody was significantly increased in SLE relatives as compared to control family members. No correlation was noted between quantitative IgG, IgA, or IgM levels and various antibodies studied.
Impaired immunoglobulin synthesis by peripheral blood lymphocytes in systemic lupus erythematosus
Authors: Nies Kenneth M. , Louie James S. 
Published: February 2007

AbstractPokeweed mitogen (PWM)‐induced immunoglobulin (Ig) synthesis by peripheral blood mononuclear cells (PBL) from 33 patients with systemic lupus erythematosus (SLE) was compared to that synthesized by PBL from 22 normal individuals. Short‐term unstimulated culture of SLE‐PBL immediately after separation from PB revealed Ig synthesis 4 times that of normal PBL. However, SLE‐PBL had a depressed PWM‐induced Ig synthetic response that was partially, but not totally, related to active disease and was not correctable by coculture with normal lymphocyte populations. In both the short‐term‐unstimulated and the PWM‐stimulated cultures, IgM was the major Ig class synthesized by normal PBL, while IgM synthesis by SLE‐PBL was depressed more than the other Ig classes. These results can best be explained by a preactivated PBL population in SLE.
Kinetic studies of phagocytosis.
Authors: Hällgren R. , HåKansson L. , Venge P. 
Published: February 2007

AbstractThe initial phagocytic rate of IgG coated polyvinyl toluene latex particles was assayed for isolated PMN cells. The kinetic studies of phagocytosis were performed in serum‐free medium using an electronic particle counter. The mean phagocytic rate for the reference group of apparently healthy individuals was 0.60 min−1. PMN cells from 5 of 26 patients with rheumatoid arthritis (RA) had subnormal values of particle ingestion rate, although the mean of the group was not significantly reduced compared to the controls. Correlation coefficient between the log of rheumatoid factor titer and phagocytic rate was 0.58 (P < 0.001). During penicillamine treatment an increased rate of phagocytosis was observed in patients with RA. Granulocytes isolated from 17 patients with systemic lupus erythematosus (SLE) had a significantly increased (P < 0.001) mean initial rate of phagocytosis (0.91 min−1). Two patients in this group had an acute exacerbation of disease activity and were treated with large doses of prednisone. An appreciable decline in phagocytic rate was observed during the intensive corticosteroid therapy.
Familial lupus. family studies of hla and serologic findings
Authors: Cleland Leslie G. , Bell David A. , Willans Martin , Saurino Bruce C. 
Published: February 2007

AbstractHLA profiles in 103 members of 4 separate kindred with multiple occurrence of SLE were compatible with the presence of a disease susceptibility factor linked to HLA or a direct effect of antigens B8, A11, and B35 on disease expression. Serum ANA was found in 52.9% of consanguineous, 56.5% of nonconsanguineous relatives of SLE probands, and 5% of controls, a finding that suggests the presence of a transmissible agent in the families. By contrast, lymphocytotoxic antibodies were not increased in relatives compared to controls.
Multiple myeloma complicating the course of seronegative systemic lupus erythematosus
Authors: Jordan Edward , Burnstein Stephen L. , Calabro John J. , Henderson Edward S. 
Published: February 2007

AbstractA patient with a 20‐year history of clinical systemic lupus erythematosus (SLE) who later developed multiple myeloma is described. SLE was diagnosed on the basis of a butterfly rash, photosensitivity, nondeforming arthritis, pleuropericarditis, and alopecia. However, the patient has never had LE cells, antinuclear antibody, or depressed complement. The patient was treated with intermittent courses of corticosteroids over a 20‐year period with good results. Multiple myeloma, diagnosed by bone marrow biopsy, has responded favorably to therapy with L‐phenylalanine mustard and prednisone.
Serologic Studies In Patients With Systemic Lupus Erythematosus And Central Nervous System Dysfunction
Authors: Winfield John B. , Brunner Carolyn M. , Koffler David 
Published: February 2007

AbstractSerologic studies were performed on 25 patients with systemic lupus erythematosus (SLE) during 29 acute episodes of central nervous system (CNS) disease. Increased anti‐DNA antibody and decreased total serum hemolytic complement activity were observed only in those patients with associated extra‐CNS disease manifestations. Patients with isolated CNS disease were otherwise in apparent clinical and serological remission regarding these two indices. No special association of cold‐reactive IgM antilymphocyte antibodies was demonstrable in patients with ongoing CNS injury. Of special interest was an increased incidence of anti‐Sm antibodies in the patients with CNS dysfunction relative to that in a large group of patients without neuropsychiatric disease. The incidence of anti‐RNP was not increased.The data do not support direct involvement in SLE brain injury of either DNA/anti‐DNA complexes or of lymphocytotoxic antibodies cross‐reactive with brain cells, but do suggest an association of anti‐Sm with CNS disease in this disorder.
Studies on immune complexes in rheumatoid arthritis
Authors: Nishimaki Tomoe , Kano Kyoichi , Milgrom Felix 
Published: February 2007

AbstractSera and synovial fluids of patients with rheumatoid arthritis were studied for immune complexes by means of the anti‐antibody inhibition test; approximately 40% of these specimens were shown to contain immune complexes. To study the nature of antigens participating in the formation of complexes under investigation, the anti‐antibody inhibition test was repeated after addition of various soluble antigens to the complex‐positive rheumatoid arthritis sera. This resulted in conversion of some sera from inhibitory to noninhibitory. It was found that of 15 positive rheumatoid arthritis sera, 7 had complexes formed by heterophile, Hanganutziu‐Deicher antigen and of 12 positive sera tested, 2 had complexes formed by human IgG.
A study of hla antigens in adults with acute rheumatic fever
Authors: Murray Garvin C. , Montiel Milka M. , Persellin Robert H. 
Published: February 2007

AbstractBy use of a microlymphocytotoxic assay to detect 32 HLA antigens of the A and B series, we examined 49 Mexican‐American adults with acute rheumatic fever and contrasted the findings with 100 ethnically identical controls. Eighty‐nine percent of the total possible antigens were identified. Strong associations between HLA antigens from either locus and acute rheumatic fever were not detected. These findings serve to emphasize the importance of nongenetic factors in the pathogenesis of acute rheumatic fever and help clarify the role of HLA antigens in rheumatic diseases.
Androgenic status of males with systemic lupus erythematosus
Authors: Stahl Neil I. , Decker John L. 
Published: February 2007

AbstractThe female predominance among patients with systemic lupus erythematosus and the protective effects of androgens in the murine lupus model prompted us to assess the androgenic status of 12 men with the disease. Save for minor abnormalities explained by treatment or renal insufficiency, normal serum testosterone, luteinizing hormone, and follicle stimulating hormone levels were found. Hypogonadism or androgen deficiency was not evident.
Antigen‐induced arthritis. decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage
Authors: Lowther Dennis A. , Sandy John D. , Santer Vivien B. , L. G. Brown Heather 
Published: February 2007

AbstractAn arthritis was induced in rabbits immunized with human serum albumin by injection of antigen into the hind knee joint. Histological changes in the synovial membrane and an increase in polymorphonuclear granulocytes in the synovial fluid indicated an inflammatory response similar to that described with fibrin as antigen (1). The arthritis was accompanied by no significant change in the collagen content, but a marked decrease in the proteoglycan content of the cartilage was noted. Cartilage from inflamed joints generally exhibited a decreased ability to synthesize proteoglycan in vitro.
The amyloidosis of juvenile rheumatoid arthritis—comparative studies in polish and american children. i. levels of serum saa protein
Authors: Filipowicz‐Sosnowska Anna Maria , Roztropowicz‐Denisiewicz Katarzyna , Julian Rosenthal C. , Baum John 
Published: February 2007

AbstractSerum SAA concentration was determined by radioimmunoassay in 21 Polish children with amyloidosis secondary to juvenile rheumatoid arthritis (JRA). The results were compared to controls and children with JRA in Polish populations (where amyloidosis is a frequent complication of JRA) as well as to American children with JRA (where amyloidosis in JRA has been observed only sporadically) and American control children. No significant differences of SAA protein levels were found in the amyloidotic Polish children when compared to JRA Polish and American children. However, significantly higher levels of SAA protein were present in amyloidotic Polish children when compared to the control Polish and American group.High serum SAA protein concentration in JRA children did not necessarily correlate with the presence of secondary amyloidosis. Other mechanisms are probably involved in the development of amyloidosis.
Atypical axial osteomalacia. report of four cases with two having features of ankylosing spondylitis
Authors: Nelson A. M. , Riggs B. L. , Jowsey J. O. 
Published: February 2007

AbstractFour patients with a clinical syndrome of musculo‐skeletal aching associated with coarse trabeculation primarily in the axial skeleton and normal or near‐normal biochemical parameters are reported. Two of these patients had a clinical syndrome consistent with the diagnosis of ankylosing spondylitis. A genetic link between the two conditions is postulated.
Gastrointestinal systemic sclerosis in serologic mixed connective tissue disease
Authors: Norman Daniel A. , Fleischmann Roy M. 
Published: February 2007

AbstractMixed connective tissue disease is a clinical entity defined by overlapping features of progressive systemic sclerosis, systemic lupus erythematosus, polymyositis, rheumatoid arthritis, and distinct serologic findings. Esophageal dilatation and dysmotility have been the only gastrointestinal manifestations reported. Three patients with serologic findings of mixed connective tissue disease and extensive gastrointestinal involvement compatible with the changes found in progressive systemic sclerosis are presented. Gastrointestinal manifestations of progressive systemic sclerosis are reviewed and were found to be indistinguishable from the findings in these patients.