bluuebunny/crossref_metadata_2025_split huggingface dataset:
Team coaching using LSP and team facilitation: a randomized control trial study measuring team cohesion and psychological safety
Authors: Passmore Jonathan , Tee David , Gold Richard 
Published: March 2024

PurposeTo date, little research has been undertaken to test the effectiveness of team coaching, with past work focusing on models, frameworks and competencies. This study aimed to examine the effectiveness of team coaching within real world organizational teams and its impact on individual perceptions of team cohesion and psychological safety.Design/methodology/approachA randomized control trial (RCT) using the comparable interventions: (1) team coaching (intervention) and (2) team facilitation (control) was employed with multiple teams and multiple facilitators, measuring the impact on team cohesion and psychological safety.FindingsThe data indicate participants engaging in the team coaching intervention made greater gains in terms of their individual perceptions of psychological safety and team cohesion than individuals who received the team facilitation intervention (T1–T2).Practical implicationsFacilitators should apply a team coaching approach when seeking to address issues of cohesion and psychological safety within workplace teams.Originality/valueThis study provides the first evidence, using an RCT method, of the effectiveness of team coaching as a workplace intervention for enhancing individual perceptions of psychological safety and team cohesion.
Uneven geographies of power in UK higher education's conjunctural crisis: A response to Gandy
Authors: Cupples Julie 
Published: March 2024

AbstractThis article constitutes a response to Matthew Gandy’s article ‘Books under threat: Open access publishing and the neo‐liberal academy in the form of a conjunctural analysis’. It discusses the UKRI (UK Research and Innovation) open‐access proposal for book publications in the context of broader and chilling attacks on academic freedom driven in large part by the current government and supported by UKRI. It argues that there is a lot at stake, not just our ability as academics to publish in university and activist presses, but also our ability to express our solidarity with Palestine, to defend the rights of transgender people, to withdraw our labour and engage in other political actions and forms of expression in the face of oppression.
An examination of the 2012–2022 empirical ethical decision‐making literature: A quinary review
Authors: Craft Jana L. , Shannon Kimberly R. 
Published: March 2024

AbstractThis review summarizes the empirical ethical decision‐making (EDM) research in business published between 2012 and 2022. Utilizing Rest's (Moral development: advances in research and theory, Praeger, New York, 1986) four‐step model for EDM and Jones' (Acad Manag Rev, 16(2): 366‐395, 1991) theory of moral intensity, 85 articles, resulting in 388 findings, were analyzed. Empirical findings in awareness, intent, judgment, and behavior were categorized by their application to individual and organizational factors resulting in the application of 624 and 62 factors, respectively. A maturing of the research environment is seen through the need for grouping individual factors into themes, essentially forming new connections within EDM research. This article prioritizes new factors and themes, such as bad behaviors, customers and selling, fantasy and imagination, and negative experiences. Additionally, new research in reoccurring themes such as demographics, feelings, personality, and power have elements that were seen in prior reviews but are more nuanced in the current. Furthermore, this quinary review discusses the evolution of EDM research highlighting the relationships studied and modifiers and mediators used. These themes help shape the landscape of EDM research by illustrating the intersectionality of variables. This article advances the understanding of how these foundational models are being nuanced to understand more deeply the EDM process. A call for future research incorporating intersectionality, the continued pursuit of complex relationships, longitudinal research, and major societal and organizational movements is included. Research into the effects of underrepresented demographics such as gender identity, veteran status, and ability is suggested. Furthermore, we question whether Rest (1986) and Jones' (1991) models are inherently Western and if comparing outcomes with a decolonialized research method might give insight into EDM. We present this latest 10‐year collection of EDM empirical research based on Rest (1986) and Jones (1991) as a tool for new and future scholars to utilize in their research endeavors.
Autozygome‐guided exome‐first study in a consanguineous cohort with early‐onset retinal disease uncovers an isolated RIMS2 phenotype and a retina‐enriched RIMS2 isoform
Authors: Del Pozo‐Valero Marta , Almoallem Basamat , Dueñas Rey Alfredo , Mahieu Quinten , Van Heetvelde Mattias , Jeddawi Laila , Bauwens Miriam , De Baere Elfride 
Published: March 2024

AbstractLeber congenital amaurosis (LCA) and early‐onset retinal degeneration (EORD) are inherited retinal diseases (IRD) characterized by early‐onset vision impairment. Herein, we studied 15 Saudi families by whole exome sequencing (WES) and run‐of‐homozygosity (ROH) detection via AutoMap in 12/15 consanguineous families. This revealed (likely) pathogenic variants in 11/15 families (73%). A potential founder variant was found in RPGRIP1. Homozygous pathogenic variants were identified in known IRD genes (ATF6, CRB1, CABP4, RDH12, RIMS2, RPGRIP1, SPATA7). We established genotype‐driven clinical reclassifications for ATF6, CABP4, and RIMS2. Specifically, we observed isolated IRD in the individual with the novel RIMS2 variant, and we found a retina‐enriched RIMS2 isoform conserved but not annotated in mouse. The latter illustrates potential different phenotypic consequences of pathogenic variants depending on the particular tissue/cell‐type specific isoforms they affect. Lastly, a compound heterozygous genotype in GUCY2D in one non‐consanguineous family was demonstrated, and homozygous variants in novel candidate genes ATG2B and RUFY3 were found in the two remaining consanguineous families. Reporting these genes will allow to validate them in other IRD cohorts. Finally, the missing heritability of the two unsolved IRD cases may be attributed to variants in non‐coding regions or structural variants that remained undetected, warranting future WGS studies.
Navigating the rights of intersex children in Zimbabwe
Authors: Gambiza Pearl , Venganai Hellen 
Published: March 2024

AbstractDespite the seemingly progressive strides made in promoting the rights of children in many African countries, the rights of intersex children remain hidden. This paper explores the lived experiences of intersex children in Zimbabwe drawing from in‐depth interviews conducted with intersex children aged between 8 and 16 years. The paper reveals a myriad of overlapping challenges faced by intersex children compounded by a lack of legal recognition and influence of cultural and religious discourses which threaten intersex children's sexual and reproductive health rights including their right to bodily autonomy and integrity, as well as their right to education.
Rotational fishery closures could enhance coral recovery in systems with alternative states
Authors: Rassweiler Andrew , Wall Lee M. 
Published: March 2024

AbstractRotational closures have potential fisheries benefits, yet their impact on coral cover is unknown. Research has shown that permanent closures can protect herbivorous fish, indirectly benefiting corals, but these observations may not apply when closed periods alternate with fishing. Here, we examine how rotational closures affect coral, focusing on systems with the potential to switch between alternative stable states, a context in which temporary closures may have persistent effects. We show that rotational closures can trigger coral recovery, and in some contexts lead to better coral recovery than fixed closures of similar size. Such benthic effects are only possible if closures last long enough for change to occur. We also note that very large fixed or rotating closures may concentrate fishing effort in areas where fishing remains permitted, leading to lower overall coral cover. Our findings offer crucial guidance to managers regarding rotational closures’ potential advantages and drawbacks.
Clinical findings of hyperechoic substantia nigra in patients with Parkinson's disease
Authors: Fan Yongyan , Ma Jianjun , Yang Dawei , Li Xiaohuan , Liang Keke , She Zonghan , Qi Xuelin , Shi Xiaoxue , Gu Qi , Zheng Jinhua , Li Dongsheng 
Published: March 2024

AbstractThis study aims to analyse hyperechoic substantia nigra (HSN) characteristics and the correlation of HSN with clinical features and blood biomarkers in patients with Parkinson's disease (PD). Transcranial sonography (TCS) evaluations of the substantia nigra (SN) were performed in 40 healthy controls and 71 patients with PD, including patients with SN hyperechogenicity (SN+) and those with normal SN echogenicity (SN−). Evaluation of motor and non‐motor symptoms was assessed by a series of rating scales. The uricase method was used to determine serum uric acid (UA) levels, and enzyme‐linked immunosorbent assay (ELISA) was used to measure plasma interleukin (IL)‐1β levels. TCS showed 92.50% specificity and 61.97% sensitivity in differentiating PD patients from controls. The area of SN+ contralateral to the side of initial motor symptoms (SNcontra) was larger than that ipsilateral to the side of initial motor symptoms (SNipsi). The PDSN+ group had lower Argentine Hyposmia Rating Scale (AHRS) scores and UA levels than the PDSN− group. Binary logistic regression analysis revealed that AHRS scores and UA levels could be independent predictors for HSN. The larger SN echogenic area (SNL) sizes positively correlated with plasma IL‐1β levels in PD patients with SN+. The present study provides further evidence of the potential of SN echogenicity as an imaging biomarker for PD diagnosis. PD patients with HSN have more severe non‐motor symptoms of hyposmia. HSN in PD patients is related to the mechanism of abnormal iron metabolism and microglial activation.
VEXAS syndrome: A review of cutaneous findings and treatments in an emerging autoinflammatory disease
Authors: Saad Anis J. , Patil Mihir K. , Cruz Nicolas , Lam Chloe S. , O'Brien Connor , Nambudiri Vinod E. 
Published: March 2024

AbstractVEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory and somatic mutation) syndrome is a novel autoinflammatory, late‐onset, disorder first identified in 2020. It is caused by mutations in the UBA1 gene. The most prominent clinical features reported by VEXAS patients are cutaneous and haematological, having characteristic skin features reported as the initial presenting findings of the disease. VEXAS is a severe and treatment‐resistant condition with high morbidity and mortality rates. Here, we examine all case reports and case series of VEXAS syndrome through March 2023 focusing on those presenting cutaneous manifestations. We discuss these manifestations and their reported treatment strategies. In many cases, it might be first suspected and diagnosed by dermatologists, highlighting their vital role in initiating timely multidisciplinary care.
Health‐related quality of life for pediatric patients with end‐stage kidney disease: A systematic review and meta‐analysis of the Pediatric Quality of Life Inventory (PedsQL)
Authors: Doshi Kush , Raina Rupesh , Ng Kar Hui , Koch Vera , Bhatt Girish C. , Nada Arwa , Foresi Brian , Kamalakkannan Sibee Sambandam , McCulloch Mignon , Sethi Sidharth , de Ferris Maria Díaz‐González 
Published: March 2024

AbstractIntroductionHealth‐related quality of life (HRQoL) studies demonstrate the impact of end‐stage renal disease (ESRD) on the physical and psychosocial development of children. While several instruments are used to measure HRQoL, few have standardized domains specific to pediatric ESRD. This review examines current evidence on self and proxy‐reported HRQoL among pediatric patients with ESRD, based on the Pediatric Quality of Life Inventory (PedsQL) questionnaires.MethodsFollowing PRISMA guidelines, we conducted a systematic review and meta‐analysis on HRQoL using the PedsQL 4.0 Generic Core Scale (GCS) and the PedsQL 3.0 ESRD Module among 5‐ to 18‐year‐old patients. We queried PubMed, Embase, Web of Science, CINAHL, and Cochrane databases. Retrospective, case‐controlled, and cross‐sectional studies using PedsQL were included.FindingsOf 435 identified studies, 14 met inclusion criteria administered in several countries. Meta‐analysis demonstrated a significantly higher total HRQoL for healthy patients over those with ESRD (SMD:1.44 [95% CI: 0.78–2.09]) across all dimensional scores. In addition, kidney transplant patients reported a significantly higher HRQoL than those on dialysis (PedsQL GCS, SMD: 0.33 [95% CI: 0.14–0.53]) and (PedsQL ESRD, SMD: 0.65 [95% CI: 0.39–0.90]) concordant with parent‐proxy reports.DiscussionPatients with ESRD reported lower HRQoL in physical and psychosocial domains compared with healthy controls, while transplant and peritoneal dialysis patients reported better HRQoL than those on hemodialysis. This analysis demonstrates the need to identify dimensions of impaired functioning and produce congruent clinical interventions. Further research on the impact of individual comorbidities in HRQoL is necessary for developing comprehensive, integrated, and holistic treatment programs.
Effects of nurse managers' inclusive leadership on nurses' psychological safety and innovative work behavior: The moderating role of collectivism
Authors: Lee Seung Eun , Seo JK 
Published: March 2024

AbstractIntroductionIn the rapidly evolving healthcare landscape, the capacity to foster innovative work behavior among nurses is increasingly important. This study examined the dynamics between inclusive leadership, psychological safety, collectivism, and innovative work behavior among nurses.DesignThe study used a cross‐sectional, correlational design.MethodsThis study utilized data from 730 medical‐surgical nurses who provided direct care to patients. Standardized instruments were used to assess key study variables. Statistical analyses, including moderated mediation regressions, were employed to investigate the complex interplay among these variables.ResultsWe found a positive association between inclusive leadership and innovative work behavior, and psychological safety mediated this relationship. Collectivism moderated inclusive leadership's direct relationship with psychological safety and its indirect relationship with innovative work behavior. The results revealed that nurses with lower levels of collectivism were more responsive to their managers' inclusive behaviors, strengthening the relation between inclusive leadership, psychological safety, and innovative work behavior.ConclusionOur findings suggest that promoting inclusive leadership behaviors among nurse managers to create a psychologically safe environment can motivate nurses to engage in innovative work behavior. However, it is also important to understand that the effectiveness of leadership may differ depending on the collectivist values of individual nurses.Clinical RelevanceNurse managers should adopt inclusive leadership behaviors, such as valuing trust, open communication, and diversity, in order to foster psychological safety and innovative work behavior among nurses.
Closed‐loop auditory stimulation of slow‐wave sleep in chronic insomnia: a pilot study
Authors: Dudysová Daniela , Janků Karolina , Piorecký Marek , Hantáková Veronika , Orendáčová Mária , Piorecká Václava , Štrobl Jan , Kliková Monika , Ngo Hong‐Viet V. , Kopřivová Jana 
Published: March 2024

SummaryInsomnia is a prevalent and disabling condition whose treatment is not always effective. This pilot study explores the feasibility and effects of closed‐loop auditory stimulation (CLAS) as a potential non‐invasive intervention to improve sleep, its subjective quality, and memory consolidation in patients with insomnia. A total of 27 patients with chronic insomnia underwent a crossover, sham‐controlled study with 2 nights of either CLAS or sham stimulation. Polysomnography was used to record sleep parameters, while questionnaires and a word‐pair memory task were administered to assess subjective sleep quality and memory consolidation. The initial analyses included 17 patients who completed the study, met the inclusion criteria, and received CLAS. From those, 10 (58%) received only a small number of stimuli. In the remaining seven (41%) patients with sufficient CLAS, we evaluated the acute and whole‐night effect on sleep. CLAS led to a significant immediate increase in slow oscillation (0.5–1 Hz) amplitude and activity, and reduced delta (1–4 Hz) and sigma/sleep spindle (12–15 Hz) activity during slow‐wave sleep across the whole night. All these fundamental sleep rhythms are implicated in sleep‐dependent memory consolidation. Yet, CLAS did not change sleep‐dependent memory consolidation or sleep macrostructure characteristics, number of arousals, or subjective perception of sleep quality. Results showed CLAS to be feasible in patients with insomnia. However, a high variance in the efficacy of our automated stimulation approach suggests that further research is needed to optimise stimulation protocols to better unlock potential CLAS benefits for sleep structure and subjective sleep quality in such clinical settings.
Dissolution of presumed calcareous corneal degeneration with 13.8% ethylenediaminetetraacetic acid solution in 17 dogs
Authors: Pytak Richard A. , Wasserman Neal T. 
Published: March 2024

AbstractPurposeTo describe a novel treatment for dissolving calcareous corneal degeneration (CCD)‐associated mineral in 17 dogs with 13.8% ethylenediaminetetraacetic acid (EDTA) solution.MethodsCases seen between 2021 and 2023 were reviewed. Seventeen dogs with CCD associated with corneal ulcerations were treated with a mineral dissolution procedure using 13.8% EDTA solution. A diamond burr keratotomy (DBK) was subsequently performed in some cases when residual mineralization remained present.ResultsOf the 19 eyes (17 dogs) included in the study, 10 eyes (8 dogs) required a DBK procedure. One eye (one dog) required a repeat procedure 26 weeks following the initial procedure and two eyes (one dog) required a repeat procedure 24 and 37 weeks following initial treatment in the left and right eye, respectively. Mean follow‐up time to last recheck for eyes not requiring a second chelation procedure was 20.4 weeks (range, 10–47 weeks). At the last follow‐up examination for all 17 dogs, the CCD resolved in 26.3%, improved in 57.9%, and recurred in 15.8% of eyes. Complications occurred in two eyes (two dogs) and included an infected stromal ulcer at 2‐week recheck and the creation of a 40% depth stromal defect immediately following debridement. Both complications were successfully addressed with medical management.ConclusionsThe utilization of 13.8% EDTA solution appears to be an effective and safe means of treating lesions associated with CCD.
Equivariant Lagrangian Floer homology via cotangent bundles of EGN$EG_N$
Authors: Cazassus Guillem 
Published: March 2024

AbstractWe provide a construction of equivariant Lagrangian Floer homology , for a compact Lie group acting on a symplectic manifold in a Hamiltonian fashion, and a pair of ‐Lagrangian submanifolds . We do so by using symplectic homotopy quotients involving cotangent bundles of an approximation of . Our construction relies on Wehrheim and Woodward's theory of quilts, and the telescope construction. We show that these groups are independent of the auxiliary choices involved in their construction, and are ‐bimodules. In the case when , we show that their chain complex is homotopy equivalent to the equivariant Morse complex of . Furthermore, if zero is a regular value of the moment map and if acts freely on , we construct two ‘Kirwan morphisms’ from to (respectively, from to ). Our construction applies to the exact and monotone settings, as well as in the setting of the extended moduli space of flat ‐connections of a Riemann surface, considered in Manolescu and Woodward's work. Applied to the latter setting, our construction provides an equivariant symplectic side for the Atiyah–Floer conjecture.
Data from Pharmacodynamic Evaluation of the Target Efficacy of SB939, an Oral HDAC Inhibitor with Selectivity for Tumor Tissue
Authors: Novotny-Diermayr Veronica , Sausgruber Nina , Loh Yung Kiang , Pasha Mohammed Khalid , Jayaraman Ramesh , Hentze Hannes , Yong Wei-Peng , Goh Boon-Cher , Toh Han-Chong , Ethirajulu Kantharaj , Zhu Joy , Wood Jeanette Marjorie 
Published: March 2024

<div>Abstract<p>SB939 is an oral histone deacetylase (HDAC) inhibitor currently in phase II clinical trials potently inhibiting class I, II, and IV HDACs with favorable pharmacokinetic properties, resulting in tumor tissue accumulation. To show target efficacy, a Western blot assay measuring histone H3 acetylation (acH3) relative to a loading control was developed, validated on cancer cell lines, peripheral blood mononuclear cells (PBMC), and in animal tumor models. Exposure of cells to 60 nmol/L (22 ng/mL) SB939 for 24 hours was sufficient to detect an acH3 signal in 25 μg of protein lysate. AcH3 levels of liver, spleen, PBMCs, bone marrow and tumor were measured in BALB/c mice, HCT-116 xenografted BALB/c nude mice, or in SCID mice orthotopically engrafted with AML (HL-60) after oral treatment with SB939. AcH3 could only be detected after treatment. In all tissues, the highest signal detected was at the 3-hour time point on day 1. On day 15, the signal decreased in normal tissues but increased in cancerous tissues and became detectable in the bone marrow of leukemic mice. In all tissues, acH3 correlated with SB939 dose levels (<i>r</i><sup>2</sup> = 0.76–0.94). When applied to PBMCs from 30 patients with advanced solid malignancies in a phase I clinical trial, a dose-dependent (10–80 mg) increase in relative acH3 was observed 3-hour postdose on day 1, correlating with C<sub>max</sub> and AUC of SB939 concentrations in plasma (<i>r</i> = 0.97, <i>P</i> = 0.014). Our data show that the favorable pharmacokinetic and pharmacodynamic properties of SB939 are translated from preclinical models to patients. <i>Mol Cancer Ther; 10(7); 1207–17. ©2011 AACR</i>.</p></div>
Machine learning on alignment features for parent-of-origin classification of simulated hybrid RNA-seq
Authors: Miller Jason R. , Adjeroh Donald A. 
Published: March 2024

AbstractBackgroundParent-of-origin allele-specific gene expression (ASE) can be detected in interspecies hybrids by virtue of RNA sequence variants between the parental haplotypes. ASE is detectable by differential expression analysis (DEA) applied to the counts of RNA-seq read pairs aligned to parental references, but aligners do not always choose the correct parental reference.ResultsWe used public data for species that are known to hybridize. We measured our ability to assign RNA-seq read pairs to their proper transcriptome or genome references. We tested software packages that assign each read pair to a reference position and found that they often favored the incorrect species reference. To address this problem, we introduce a post process that extracts alignment features and trains a random forest classifier to choose the better alignment. On each simulated hybrid dataset tested, our machine-learning post-processor achieved higher accuracy than the aligner by itself at choosing the correct parent-of-origin per RNA-seq read pair.ConclusionsFor the parent-of-origin classification of RNA-seq, machine learning can improve the accuracy of alignment-based methods. This approach could be useful for enhancing ASE detection in interspecies hybrids, though RNA-seq from real hybrids may present challenges not captured by our simulations. We believe this is the first application of machine learning to this problem domain.