bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of long term patient satisfaction in orthognathic surgery
Authors: Tabakan Ibrahim , Kokacya Omer , Kesiktas Erol , Eser Cengiz , Gencel Eyuphan 
Published: February 2025

Objective: Even though there are many reliable data that deal with orthognatic surgery, there is very little information about patient satisfaction. When evaluating the success of the surgery, clinicians usually take postoperative occlusion and cephalometric measurements into consideration. However for the patietns, aesthetic appearence is as important as occlusion.
Material and Methods: 80 patients who underwent orthognathic surgery between 2003-2011 in Çukurova University were studied. Patients were interviewed either personally or by the phone with a questionairre that reflect patient satisfaction such as preoperative and postoperative aesthetic facial apperance, change in self confidence, mastication, hypoestesia and pain in temporomandibular joint.
Results: 22,5 % of the patients stated that there was aesthetic improvement, 8,8 % stated only improvement in mastication and 62,5 % stated there was improvement in both. A total of 70 %(n=56) of the patients pointed out there was significant improvement in their self esteem.
Conclusion: This study suggests that outcomes of the surgeries can be evaluated not only by occlusion and cephalometric measurements but also with subjective complaints and satisfaction of the patients. To achieve long term success in orthognathic surgery, one should know the relationship between function and aesthetic facial appearence and take both of them into consideration equally.
Plasma adrenomedullin levels in patients with migraine during natural attack and attack free period
Authors: Akcali Aylin , Geyik Sirma , Dogru Ilker , Dogru Arzu , Yurekli Muhittin , Neyal Abdurrahman , Balat Ayse , Neyal Munife Ayse 
Published: February 2025

Objective: The role of Calcitonin G related peptide (CGRP) in migraine has been demonsrated. The aim of this study was to examine the role of Adrenomedullin (AM) which is a member of the calcitonin/CGRP/amylin family in migraine patients during naturel attack and attack free period.
Material and Methods: 26 migraine patients (11 with aura, 15 without aura) and 26 healty participants were involved. Blood samples were obtained from each patient in attack and attack free period, then compared with each other and control group.
Results: Mean plasma AM levels were 18.95 pmol/L during migraine attacks, 26.01 pmol/L between attacks, and 33.38 pmol/L in the control group. AM levels of migraine patients were significantly lower than controls during non-attack periods (p=0.001) and more interestingly, it further decreased during attack periods (p=0.001). A comparison of the mean plasma AM levels of migraine with and without aura cases revealed the same statistically significant difference (p=0.00).
Conclusion: The persistently low AM levels in migraine patients gave the impression that in physiological conditions there may be a balance between CGRP and AM and this may be changed towards to the site of CGRP in migraine pathophysiology while causing a decline in AM levels as we had found. Further studies regarding on AM involvement in migraine pathophysiology are needed to confirm these results.
The laparoscopic management of the ureteropelvic junction obstruction: Our initial experience
Authors: Bolat Mustafa Suat , Acikgoz Abdullah , Akdeniz Ekrem 
Published: February 2025

Objective:Higher morbidity rates, extensive scar tissue formation and longer hospitalization periods of the standard open surgical methods for ureteropelvic obstruction has led to acceleration of minimal invasive techniques. Success rate and clinical outcomes of laparoscopic pyeloplasty has become comparable with open surgery.
Purpose:The aim was to evaluate the clinical results and complications of transperitoneal laparoscopic pyeloplasty in ureteropelvic obstruction.
Material and Methods:Thirty-three patients with ureteropelvic obstruction were enrolled into this study. Eighteen patients underwent Anderson-Hynes dismembered Pyeloplasty and 15 underwent Y-V plasty. Patients were followed-up at postoperative 3., 6. months and then yearly. Partial or total relief of symptoms and improvement in diuretic renogram were accepted as success.
Results:Median age was 34.5±15.5(13-74) years, number of males were 13 (39.4%) and females were 20 (60.6%). Median Body Mass Index (BMI) was 25.3±15.4(18.5-33.4). Eight were asymptomatic, and 23 had intermittent pain, preoperatively. Fourteen cases had left ureteropelvic obstruction (42.4%) and 19 had in the right kidney. Intraoperatively 19 cases had aberrant vessel. Mean surgery time was 127.9±38.9 (68-245) minutes, median anastomosis time was 20.8±7.3 (8-39) minutes. Median blood loss was 57.1±28.3 (20-150) mL, median postoperative drainage time was 2.6±1.1 (2-7) days. Only one had prolonged ileus and peritoneal irritation findings. Median narcotic and nonnarcotic requirements were 21.5±4.8 (15-30) and 132.6±37.2 (75-200) mg/day, respectively. Median follow-up period was 35.1±13.6 (11-59) months.
Conclusions:Laparoscopic pyeloplasty, is minimally invasive and reliable technique replaces open pyeloplasty in many institutions. Shorter hospitalization, lower postoperative morbidity rates, better cosmetic results and higher success rates can be easily achieved..
The effect of statin use on lens density as assessed by pentacam hr® lens densitometry in adults
Authors: Cakir Akin , Tokatli Alptug , Kar Taner , Yildirim Yildiray , Duzgun Eyup , Erdal Emrah 
Published: February 2025

Objective: To investigate the association between statin use and cataract development by using Pentacam HR Scheimpflug camera system.
Material and Methods: Total 208 age and sex matched participants were included in this prospective, case-control study. 104 long-term statin users as study group and 104 non-statin users as control group constituted to the study. Lens densitometry measurements were performed with the Pentacam HR® (Oculus, Wetzlar, Germany) from three areas (anterior, nuclear, and posterior). These measurements were compared between the groups.
Results: There were no significant difference at the basic clinical variables (p=0.121, p=0.778). The mean duration of statin use of the study group was 5,4±4,3 years. The mean value of lens densitometry measurement at nuclear area tended to be lower in statin users than controls, but difference was not statistically significant (9.20±1.00 vs 9.35±1.20; p:0.346). However, the mean lens densitometry values at the anterior and posterior areas of statin users were found to be significantly higher than controls (10.44±1.32 vs 9.16±1.09;p<0.001; 7.86±0.49 vs 7.63±0.38; p<0.001,respectively).
Conclusion: The current study finds that long-term statin use seems to be associated with an increased risk of cortical cataracts (anterior-posterior) but not incidence of nuclear cataracts.
Primary small B cell non-Hodgkin Lymphoma of the Lacrimal Sac Upon Chronic Dacryocystitis
Authors: Gumussoy Murat , Uluyol Sinan , Kucuk Ulku , Kurtoglu Gokhan , Kandogan Tolga , Cukurova Ibrahim 
Published: February 2025

Primary non-Hodgkin lymphoma of the lacrimal sac is an extremely rare tumor. In this article, we report a 44-year-old female who was referred for dacryocystorhinostomy with complaints of epiphora and swelling on the right lacrimal sac region. She had slight epiphora for 8 years, which increased within 6 months, with concomitant swelling between the eye and the nose. A hard and fixed mass was detected on palpation just below the medial canthus. Magnetic resonance imaging showed a 30x35 mm tumoral, lesion which invaded the medial wall of the right orbit and compressed the medial rectus muscle. Histopathologic examination of the tumor revealed a small B cell non-Hodgkin lymphoma. As a conclusion, we suggest that if symptoms of a chronic dacryocystitis patient deteriorates, malignancy should be suspected
Major acute pain complications in Congolese children with sickle cell disease
Authors: Ngolet Lydie Ocini , Engoba Moyen , Dokekias Alexis Elira , Innocent Kocko , Moyen George 
Published: February 2025

Sickle cell disease is the most frequent genetic blood disorder in the world and pain complications are the most prominent clinical aspects in sickle cell population.
Objectives: Describe the morbidity feature of major acute pain complications in children with sickle cell disease and outcome.
Material and Methods: 166 sickle cell disease children (4.3%) with a mean age of 85.31 months old±60.40 admitted in the pediatric intensive care unit for major acute pain complications were enrolled in the study from January to December 2014. Major acute pain complications were defined as acute sickle cell related pain with an intensity assessed at 3 on the Wong-Baker faces pain rating scale.
Results: Over the period study, 118 patients were admitted for diffuse vaso occlusive crisis (70.09%). Localized vaso occlusive crisis occurred in 13.25%, acute chest syndrome in 09.64% and hand foot syndrome in 06. 02%. The most common trigger factors were bacterial infections (65.12%) followed by malaria (34.88%). Mortality of 12.05% was recorded while 27.71% were discharged and 60.24% transferred to other departments. The mortality rate was significantly higher in the range age over 5 years (p=0.004)
Aneurysm of the Internal Carotid Artery Pressing on Dorello’s Canal in a Patient with Bilateral Abducens Nerve Palsy: Case Report
Authors: Cuce Ferhat , Ozgonul Cem , Eroglu Ahmet , Oztimucin Ozgur Bulent , Verim Samet 
Published: February 2025

Objective: Abducens nerve palsy (ANP) has an incidence of 11.3/100,000. ANP related to pressure of the aneurysm on the Dorello’s canal is unusual. We report a case of bilateral ANP following head trauma.
Case: A 31-year-old woman was admitted for the evalu­ation of diplopia began after trauma. In the diagnostic imaging; the magnetic resonance imaging (MRI) revealed the normal course of bilateral abducens nerve (AN) in the pontine cistern. The adjacent anatomy of the right AN from pons up to the oculer bulb was normal. But the distal part of the left ICA petrous segment at the level of foramen lacerum had a remarkable loss of signal void. Multidetector computed tomography angiogram demonstrated a left distal petrous ICA aneurysm which was under the Dorello’s canal and remodeling the clivus.
Conclusion: We estimated the left ANP was caused by the pressure of the aneurysm. And the right ANP was probably due to the trauma the patient had experienced.
A possible alternate pathway for intravascular thrombosis - Investigation of the circumstantial evidence by microfluidics
Authors: Das Siddhartha , Barai Amlan 
Published: February 2025

In light of the literature, in this hypothesis, we aimed to settle up an experimental procedure and possible mechanism for bacteremia induced disseminated intravascular coagulation via QA.Bacteremia resulting in sepsis and disseminated intravascular coagulation (DIC) are known for thrombosis and coagulopathy. DIC, which results in simultaneous activation and consumption of coagulation factors, could be investigated using microfluidics as a tool. Here, we propose the hypothesis that bacteria (e.g. E.coli) mediated DIC results from a collective phenomenon called “quorum acting” (QA). If our hypothesis is true, than the coagulation cascade will be activated before systemic inflammation. To check for QA we propose to perform a hemodynamic experiment where blood is controllably flown over E.coli clusters in a microfluidic device. Further, manipulation of the physical properties (flow rate mimicking condition like venous stasis) and chemical properties (hyperglycaemia as in uncontrolled diabetes mellitus) of blood could be done using microfluidic device to mimic their etiopathogenesis and to validate our proposed mechanism that quorum acting mediated DIC occurs rapidly in venous stasis and uncontrolled diabetes mellitus respectively.
A novel volumetric analysis using cad/cam scanners in gingival recession treatment
Authors: Aydinyurt Hacer Sahin , Ertugrul Abdullah Seckin 
Published: February 2025

Objective: In this study, randomized clinical trial (RCT), the aim was to compare clinical periodontal data of subepithelial connective tissue graft (SCTG) group and SCGT+enamel matrix derivatives (EMD) group in terms of gained gingiva volume (GGV) and gained gingiva surface area (GGSA) by scanners of computer-aided design/computer-aided manufacturing (CAD/CAM) devices.
Material and Methods: In this study, a total of 35 Miller class I-II gingival recession defects were involved (n=17 in SCTG group, n=18 in SCTG+EMD group). In addition to, periodontal clinical parameters, and three dimensional (3D) images were recorded by using CAD/CAM system before the treatment, at the 1st month and the 6th months after the treatment. The images were superimposed by using softwares and GGV, and GGSA were calculated.
Results: There was no significant difference in terms of GGV and GGSA values at the 1st month and 6thmonths between SCTG+EMD and SCTG groups. Similarly, there was no significant difference in periodontal clinical parameters between groups.
Conclusion: Images obtained from CAD/CAM system can be easily used in calculating GGV and GGSA data after the gingival recession treatment and in determining of the success of administered treatment. It is expected that the evaluation of the success of many therapeutic approaches for periodontal treatment will be carried out by using CAD/CAM system in the future.
The effects of application of 0.5% levobupivacaine together with 5 mg dexamethasone for infra-clavicular block in surgical treatment of forearm fractures
Authors: Kilic Ertugrul , Karsli Burcin , Evrenos Mustafa Kursat , Erkek Murat , Mizrak Ayse 
Published: February 2025

Objective: We aimed to investigate the effects of adding 5mg dexamethasone to 0.5% levobupivacaine on postoperative analgesia after US-guided infra-clavicular block.
Methods: This prospective study was performed at Sehitkamil Goverment Hospital, Gaziantep, Turkey, between september 2012 and february 2013. Ninty patients presented with fracture of forearm bones. Patients were randomly allocated to receive ultrasound guided infraclavicular brachial plexus blockade using levobupivacaine 0.5% in conjunction with or without dexamethasone 5 mg. In Group I (n=45), 0.9% NaCl was added as adjuvant. In Group II (n=45), 5 mg dexamethasone was added to 0.5% levobupivacaine and surgical anesthesia was provided. Postoperative pain control was provided by using morphine with intravenous patient controlled analgesia (IVPCA). one mg bolus dose was administered, continued with limit of 5 mg/hour and 10 min of locking time. Verbal ranting scala (VRS), patient satisfaction score (PSS) and total morphine consumption were controlled for postoperative 48 hours.
Results: Sensory block onset time was significatly longer in group I. Sensory block time was longer in group II. PSS was higher in group II, total morphine consumption was found more in group I, VRS was significantly higher in group I.
Conclusion: Application of 0.5% levobupivacaine together with 5 mg dexamethasone for infra-clavicular block in surgical treatment of forearm fractures reduces sensory block initiation time, prolongs duration of Sensorial Block and reduces analgesic consumption.
Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome
Authors: Sayiner Zeynel Abidin , Okyar Burak , Eraydin Ayten , Ozkaya Mesut 
Published: February 2025

Bartter syndrome and Gitelman syndrome are rare autosomal recessive syndromes. In extremely rare cases, GS may diagnosed with growth retardation and diabetes mellitus. In this 3-case series, growth retardation was identified at 17-year follow-up of our dizygotic twin patients diagnosed with BS and glucose metabolism disorder was developed. Whereas, 3RD. patient diagnosed with GS in adulthood period developed diabetes mellitus after 8 years follow up. Chronic hypopotassemia has been shown to cause diabetes mellitus and growth retardation ın several articles. Potassium plays an important role in insulin, IGF-1 and growth hormone cycle. Herein, we aimed to draw attention to that, the presence of chronic hypopotassemia may precipitate to diseases such as growth retardation and diabetes mellitus over time.
Evaluation of factors that affecting mortality in urgent redo-laparotomies
Authors: Uysal Erdal , Turel Kadir Serkan , Sezgin Efe 
Published: February 2025

Objective: The aim of this study was to investigate the factors that affect mortality in patients undergoing Urgent abdominal redo-laparatomies (UARLs) and to analyze the common indications and operative,demograhic and clinical characteristics in UARLs.
Material and Methods: Our study was designed as a retrospective, observational and multi-centric study. A total of 155 patients from two separate clinics undergoing urgent, unplanned redo-laparatomy were included in the study. The data obtained from all clinics were collected and and the relations of the demographic, clinical and operational factors with the mortalities of primary surgery and multiple UARLs were analyzed.
Results: Mortality was observed in 42 (27%) patients. The most frequent causes of mortality were sepsis and multi-system organ failure in 23 (53.4%) patients. The relationships between the number of redo-laparotomy presence of blood transfusion, older age,classification of surgery and mortality were significant (p<0.05).
Conclusion: Sepsis and multi-organ failure were the most frequent cause of mortality in our study as well, with a rate of 53.4 %. No significant relationship was observed between mortality and initial surgery under emergency conditions and presence of comorbidity. Redolaparatomies inevitable in some clinical situations. Since multiple redolaparatomies are associated with mortality , it is necessary to avoid complications during initial surgery to reduce UARLs. Major surgery operation UARLs in elderly people should be avoided. Finally, the surgeon should also make the UARLs decision at the right time.
Synthesis of Borono Fluoro Deoxy D glucose as Boron carrier for Boron neutron capture therapy (BNCT)
Authors: Akan Zafer , Ozel Taner , Oto Gokhan , Ozdemir Hulya 
Published: February 2025

Objective: The 18F-labeled Deoxy-D-Glucose exhibits high affinity to cancer tissue as a PET (Positron Emission Tomography) imaging agent for metastatic cancers. Complexation of 10B to 18F-DG complex may create a useful BNCT (Boron Neutron Capture Therapy) agent for cancer therapy. In previous studies, complexation and characterization of 10B with DG were evaluated and biodistribution analysis was completed successfully. Radioactive tracer labeled 10B-DG will be a useful approach to uses for BNCT applications.
Methods: The 18F-DG synthesized by ion exchange and complexed with 10B(OH)3 via pH reactions. 18F-DG-10B complexation was assayed with Agilent 1260 Infinity HPLC-DAD and Agilent 6420 Triple Quad LC/MS. Complexed molecule defragmented and fragmentation products assayed with Agilent 6420 Triple Quad LC/MS for confirmation.
Results: 10B-18F-DG complex was obtained with ion-exchange pH reaction successfully. Complexation of two 10B(OH)3 to 18F-DG was determined with Triple Quad LC/MS. Purification of 10B-18F-DG is currently in progress.
Conclusions: Radio-labelled 10B-DG will supply new insight to research for BNCT studies. Cancer detection and therapy will be applicable in the same schedule with 10B-18F-DG complex.
Importance of enzyme immobilization for human health
Authors: Yalcinkaya Zeki , Turan Hakan , Demir Halit 
Published: February 2025

In this review, we aimed to emphasize the importance of immobilized enzymes for human health in shed light on recent literature. In addition to our clinical experiences, some literature studies on immobilized enzymes were evaluated. The immobilized enzymes bind to a specific region physically by using mediator enzymes and shows catalytic activities repeatedly and continuously without losing their catalytic activities. In other words, enzyme immobilization is the trapping or binding of the insoluble form of the enzyme or the carrier agent to itself. Compared to free enzymes in solution, immobilized enzymes are tougher and more resistant to environmental changes. Some immobilized enzymes are also used in various industries. Immobilization techniques are generally used in industrial processes, diagnostics, bio-affinity chromatography and biosensors applications. As recently, immobilized enzymes have begun to be used in dissolving blood clots and clearing wounds.
Pre/post-surgical investigation of some angiogenic factors due to cancer and obesity
Authors: Guler Sertac Ata , Yurekli Atilla , Canturk Nuh Zafer , Posteki Gokhan , Simsek Turgay , Tatar Ozan Can , Yurekli Muhittin 
Published: February 2025

Objective: Obesity is one of the important health problem for developed and developing countries. Due to literature some obesity related factors may trigger the tumor formation. For tumor development, tumoregenic cell and tissue needs to oxygen and nutrients. Once the tumor has developed, it stimulates the angiogenesis by producing chemical signals and grows by supplied oxygen and nutrients with newly formed vessels. Aim of this study is to compare some angiogenic factors before and after surgery which will supply more information about the link between the cancer and obesity.
Material and Methods: Serum samples were obtained before and 48 hours after surgery. Adrenomedullin, vascular endothelial growth factor, hipoxia inducible factor1-α and matrix metallo proteinase-2 levels were investigated in cancerous and noncancer patients. Angiogenic factors were assayed by ELISA method.
Results: Higher levels of angiogenic factor were detected in cancer tissues more than in non-cancer tissues, in pre-obese and obese patients. It is seen that in humans, in post-operated patients angiogenic factors are higher in obese individuals, while non-cancer patients are also higher in obese groups and angiogenic factors which stimulate angiogenesis.
Conclusion: In the treatment of cancer, as defined previously the anti-angiogenic factors should be considered and applied as epigenetic phenomen. Due to our finding cancer related elevated angiogenic and growth factor biochemicals had been also increased in obes population and in cancer patients with surgical intervention. In the light of literature and our findings, instead of drugs, radiation therapy or surgery, which have many side effects in the treatment of cancer, we need to focus to this epigenetic phenomen for cancer patients. In general, we can say that both obesity and surgical applications lead to an increase in angiogenic factor levels, and that the healing process of wounds causes a marked increase in angiogenic factor levels