bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of the (Z) and (E) isomers of 1,2‐diaryl‐3‐methyl‐4,5‐dioxo‐3‐pyrrolidinecarboxylic acid esters. Structural assignment by nmr and mass spectroscopy
Authors: Titus Richard L. , Emerson David W. , González Rowena M. 
Published: March 2009

AbstractReaction of N‐benzylideneaniline, 1a, with 3‐methyl‐2‐oxobutanedioic acid diethyl ester, 2a, produced isomeric 3‐methyl‐4,5‐dioxo‐1,2‐diphenyl‐3‐pyrrolidinecarboxylic acid ethyl esters, 3a and 3b. The higher melting isomer, 3a, was shown to have the (Z) configuration by nmr spectroscopy. The (Z) and (E) isomers of 3‐methyl‐4,5‐dioxo‐1,2‐diphenyl‐3‐pyrrolidinecarboxylic acid methyl esters, 3c and 3d, were prepared from 1a and 3‐methyl‐2‐oxobutanedioic acid dimethyl ester, 2b. The higher melting isomer, 3c, was shown to have the (Z) configuration. Similarly, N‐benzylidene‐p‐toluidine, 1b, reacted with 2a to form (Z) and (E) isomers of 3‐methyl‐4,5‐dioxo‐1‐(4‐methylphenyl)‐2‐phenyl‐3‐pyrrolidinecarboxlic acid ethyl esters, 3e and 3f. Assignment of the 13C carbonyl carbon nmr chemical shift was made by preparing 2‐methyl‐3‐oxobutanedioic‐1‐13C acid diethyl ester, 4, and from it the corresponding (Z) and (E) isomers of 3‐methyl‐4,5‐dioxo‐1,2‐diphenyl‐3‐pyrrolidinecarboxylic 13C acid ester, 5a and 5b. The mass spectra of the (Z) isomers exhibit prominent ions corresponding to the masses of the Schiff bases used to make them, and ions corresponding to the loss of ArNCOCO from the parent ion. The (E) isomers 3b, 3d and 5b exhibit a prominent ion of mass 264; 3f gives mass 278, corresponding to the loss of the carboalkoxy group.
Stereospecific cycloaddition of heterocumulenes to oxiranes catalyzed by organotin halide complexes
Authors: Baba Akio , Seki Kenji , Matsuda Haruo 
Published: March 2009

AbstractStereospecific cycloaddition of 2,3‐disubstituted oxiranes to heterocumulenes, including carbodiimides, isocyanates and carbon dioxide, is catalytically promoted by dialkyltin diiodide‐hexamethylphosphoric triamide (HMPA) system, producing various five‐membered heterocycles, where the configuration of the carbons in the oxirane ring is retained. In particular, the addition of isocyanates to oxiranes gave stereo‐specifically two types of products, dioxolan‐2‐imines and oxazolidin‐2‐ones independently, while the rearrangement of the former to the latter product has been already proposed.
Synthesis and 13C NMR spectra of cis‐ and trans‐{2‐(haloaryl)‐2‐[(1H‐imidazol)‐1‐yl]methyl]}‐1,3‐dioxolane‐4‐methanols
Authors: Chapman David R. , Bauer Ludwig 
Published: March 2009

AbstractSyntheses and 13C nmr spectra of a number of cis and trans 2‐(haloaryl)‐2‐[(1H‐imidazol‐1‐yl)rnethyl]‐4‐(hydroxymethyl)‐1,3‐dioxolanes are described. The haloaryl groups are 2,4‐dichloro, 2,4‐difluoro‐, 4‐chloro‐and 4‐bromophenyl. In these series, some of the cis compounds become available through crystalline bromo benzoates 5. Separations of some trans isomers are achieved through fractional crystallizations of imidazolyl benzoate nitrates 6. Stereochemical assignments are based primarily on one major 13C chemical shift difference, namely that of C‐4 of the 1,3‐dioxolane ring, the chemical shift of the trans isomers being 1.0‐2.5 ppm downfield from that of the cis isomers.
An improved resolution of (±)‐cis‐N‐normetazocine
Authors: Brine G. A. , Berrang B. , Hayes J. P. , Carroll F. I. 
Published: March 2009

AbstractThe optical isomers of cis‐N‐normetazocine are the starting materials for the synthesis of a number of pharmacologically useful compounds. An improved resolution procedure for obtaining these isomers is reported.
Synthèses de 1,2,4‐triazolo[4,3‐d][1,4]diazépines et de 1,2,4‐oxadiazolo[4,5‐d][1,4]diazépines par cycloaddition dipolaire‐1,3
Authors: Hasnaoui A. , Baouid A. , Lavergne J.‐P. 
Published: March 2009

AbstractNous décrivons ici une synthèse en une étape de 1,4,5,6,7,9a‐hexahydro‐1,2,4‐triazolo[4,3‐d][1,4]diazépines, 4‐6, et 1,2,4‐oxadiazolo[4,5‐d][1,4]diazépines, 7‐10 et 12, par cycloaddition de nitrilimines, et d'oxydes de nitrile avec les 1‐méthyl 2,3‐dihydro‐1H‐1,4‐diazépines, 1 et 11. Dans tous les cas ces réactions sont péri et régiosélectives (la double liaison C‐N est seule affectée) et s'effectuent avec de bons rendements. Les structures et les conformations des cyclo adduits ont été determinés à partir des spectres de rmn.
Caractérisation de nouveaux dérivés et analogues de la nétropsine et identification de leurs intermédiaires de synthèse par spectrométrie de masse FAB
Authors: Aubagnac Jean‐Louis , Debart Françoise , Mrani Driss , Gosselin Gilles , Rayner Bernard , Imbach Jean‐Louis 
Published: March 2009

AbstractThe fast‐atom bombardment (FAB) mass spectra of a series of netropsin derivatives and analogues were examined in positive‐ion and when necessary negative‐ion modes. Behaviour of these derivatives was related to that of oligopeptides. Some compounds protected by t‐butoxycarbonyl groups were also investigated using this technique and showed characteristic fragmentations.
Use of 1,3‐dioxin‐4‐ones and their related compounds in synthesis. Part 28. Asymmetric de mayo reactions using chiral spirocyclic dioxinones
Authors: Sato Masayuki , Abe Yoshito , Takayama Kazuhisa , Sekiguchi Keiko , Kaneko Chikara , Inoue Naoko , Furuya Toshio , Inukai Noriyoshi 
Published: March 2009

AbstractThe use of rigid spirocyclic dioxinones having 1‐menthone as the chiral auxiliary as the enones in the photo[2 + 2]cycloaddition reactions opened novel methods for obtaining enantiomerically pure compounds, such as iridoids. Convex side preference of the sofa‐conformation of these dioxinones in the photoaddition to cyclopentene increases up to 100% by introducing either a bulky substituent or 5‐hexenyl group at the 3‐position to these dioxinones and, hence, highly asymmetric inter‐ and intramolecular de Mayo reactions have been disclosed.
Reactions of azoesters and dimethyl acetylenedicarboxylate with 3‐methyl‐1,2,4‐triazole‐5‐thione
Authors: Giammona Gaetano , Neri Maria , Carlisi Bianca , Palazzo Aldo , La Rosa Carmelo 
Published: March 2009

AbstractThe addition of dimethyl acetylenedicarboxylate to 3‐methyl‐1,2,4‐triazole‐5‐thione (1), both in alcoholic medium and in inert solvents, has been investigated. When 1 was allowed to react with diethyl azodicarboxylate a disulfide 5 was obtained.
Carbon‐13 nuclear magnetic resonance spectra of 1,2,3,4‐tetrahydroquinazoline and some 3‐benzyl derivatives
Authors: Gravier D. , Dupin J.‐P. , Casadebaig F. , Hou G. , Petraud M. , Moulines J. , Barbe B. 
Published: March 2009

AbstractThe concerted use of the 1H/13C shift correlation with full 1H/1H decoupling and the modified COLOC sequence for long‐range X/H correlation 2D nmr spectroscopy allows the total assignment of the 13C nmr resonances of 1,2,3,4‐tetrahydroquinazoline and 3‐benzyl‐1,2,3,4‐tetrahydroquinazoline. From these data, the 13C nmr chemical shifts of a series of 3‐benzylsubstituted‐1,2,3,4‐tetrahydroquinazolines are deduced.
Substitutions homolytiques intramoléculaires. 17. Décomposition de peroxydes de ϵ‐alcényle et de t‐butyle. Accès à des tétrahydropyranes substitués
Authors: Montaudon E. , Campagnole M. , Flies F. , Maillard B. 
Published: March 2009

AbstractLa décomposition induite du peroxyde de t‐butyle et d'hex‐5‐ényle dans des solvants bons donneurs d'hydrogène conduit à des tétrahydropyranes substitués en 2 accompagnés de peroxydes adduits. La substitution du peroxyde modifie les proportions relatives de ces deux types de composés.
Studies of pyridazine compounds. XXVI. The synthesis of Pyridazino[4,5‐b]pyrrolo[1,2‐d][1,4]oxazines and a pyridazino[4,5‐b]pyrrolo[1,2‐d][1,4]thiazine
Authors: Varga Ildikò , Jerkovich Gyula , Màtyus Péter 
Published: March 2009

AbstractThe tricyclic oxazines 3 and 5 were obtained by ring closure of (2‐hydroxymethyl‐1‐pyrrolidinyl)‐3(2H)‐pyridazinones 2d,e,g, respectively, prepared from 4,5‐dichloro‐3(2H)‐pyridazinones with L‐prolinol. The synthesis of the thiazine analogue 4a was achieved by treatment of 2d with thionyl chloride and the subsequent reaction with sodium sulfide. The structures of the compounds were supported by spectroscopic evidence.
Nitrogen Bridgehead Compounds. Part 79. Synthesis and structure elucidation of benzimidazolo[2,1‐f][1,6]naphthyridine aza‐derivatives
Authors: Tóth Gábor , Kovács Attila , Balogh Mária , Hermecz István 
Published: March 2009

Abstract6‐Substituted 1,6‐naphthyridine‐5(6H)‐ones were prepared from diethyl 2‐[2‐(dimethylamino)vinyl]‐6‐methylpyridine‐3,5‐dicarboxylate 1 [2] by ring closure with aromatic and heteroaromatic diamines (o‐phenylenediamine, 2,3‐diaminopyridine, 3,4‐diaminopyridine and 4,5‐diaminopyrimidine, respectively). 1,6‐Naphthyridine‐5(6H)‐ones were cyclised in phosphoryl chloride to yield nitrogen bridgehead tetracycles 6‐9. The structure of the products was established by nOe difference spectroscopy. A complete 1H and 13C nmr assignment was achieved by different 2D carbon‐proton correlation measurements.
Synthesis and reactions of halogenated thiazole isocyanates
Authors: South Michael S. 
Published: March 2009

AbstractA synthesis of 2‐chloro‐4‐(trifluoromethyl)‐5‐isocyanatothiazole and 2,5‐dichloro‐5‐isocyanatothiazole is described via the “Curtius Rearrangement” performed under anhydrous conditions. The synthetic procedure described allows for the isolation, storage, and manipulation of these highly reactive isocyanates. A number of derivatives of the above isocyanates were prepared. These include: carbamates, thiocarbamates, ureas, amines, amidines, and amides.
Synthesis, X‐ray crystal structure determination and antiinflammatory activity of the regioisomers: 5‐phenyl‐6‐(4‐pyridyl)‐2,3‐dihydroimidazo[2,1‐b]thiazole and 6‐phenyl‐5‐(4‐pyridyl)‐2,3‐dihydroimidazo[2,1‐b]thiazole. A structural reassignment
Authors: Shilcrat Susan C. , Hill David T. , Bender Paul E. , Griswold Don E. , Paul W.  , Eggleston Drake S. , Lantos Ivan , Pridgen Lendon N. 
Published: March 2009

AbstractA regiospecific synthesis of 6‐phenyl‐5‐(4‐pyridyl)‐2,3‐dihydroimidazo[2,1‐b]thiazole (2) was accomplished by treatment of 6‐phenyl‐2,3‐dihydroimidazo[2,1‐b]thiazole (10) with the reactive complex of pyridine and ethyl chloroformate followed by oxidation with chromium(VI) oxide. Reaction of 4‐phenyl‐5‐(4‐pyridyl)imidazole‐2‐thione (12) with 1,2‐dibromoethane in the presence of base also gave 2 together with its regioisomer 3. The structures of 2 and 3 were confirmed by X‐ray crystallography. Evaluation, on oral administration, in a one hour arachidonic acid‐induced mouse ear inflammation assay, showed the inhibition of edema by 2 (48%) and 3 (34%) to be less than that of the 6‐(4‐fluorophenyl) analog 1 (SK&/F 86002) (69%), a known antiinflammatory agent.
Synthesis of new heterocyclic phenols: 9‐Hydroxypyrido[1,2‐a]pyrimidin‐4‐one and Derivatives
Authors: Dennin F. , Blondeau D. , Sliwa H. 
Published: March 2009

Abstract9‐Hydroxypyrido[1,2‐a]pyrimidin‐4‐one (5) was prepared by condensation of 2‐amino‐3‐hydroxypyridine with isopropylidene aminomethylenemalonate. The reaction first led to an enaminoester intermediate which underwent cyclization by heating at 250° affording the new heterocyclic phenol 5. A similar condensation performed on 2‐amino‐3‐benzyloxypyridine yielded the corresponding benzylic ether which can be easily debenzylated to 5 by hydrogenolysis. Furthermore 2‐amino‐3‐benzyloxypyridine condensed with diethyl ethoxymethylenemalonate gave 9‐benzyloxy‐3‐ethoxycarbonylpyrido[1,2‐a]pyrimidin‐4‐one which was also debenzylated to the corresponding free phenol.
Assignment of the proton and carbon NMR spectra of the indoloquinoline alkaloid cryptolepine
Authors: Tackie Albert N. , Sharaf Maged H. M. , Schiff Paul L. , Boye Gilbert L. , Crouch Ronald C. , Martin Gary E. 
Published: March 2009

AbstractThe relatively rare alkaloid cryptolepine, 5‐methyl‐5H‐indolo[3,2‐b]quinoline, was isolated from Cryptolepis sanguinolenta (Lindl.) Schlecter (Asclepiadaceae). Unequivocal proton and carbon nmr assignments in dimethyl sulfoxide are reported based on two‐dimensional nmr methods, including COSY, inverse‐detected direct (HMQC), and long‐range (HMBC) correlations. Several of the assignments were confirmed using one‐dimensional SIMBA spectra ‐ a new, selective, one‐dimensional analogue of the proton‐detected long‐range heteronuclear shift correlation experiment (HMBC). The SIMBA experiment was also used in an attempt to observe a two‐bond coupling from the H11 proton to C10a at several optimizations.
A photochemical synthesis of 3‐aryl‐1‐methylquinolinones
Authors: Meng Ji‐Ben , Shen Mei‐Qen , Wang Xiao‐Hong , Kao Chen‐Heng , Wang Ru‐Ji , Wang Hong‐Gen , Matsuura Teruo 
Published: March 2009

AbstractA number of fluorescent 3‐aryl‐1‐methylquinolinones 3 were synthesized by the regiospecific photocoupling reaction of 3‐halo‐1‐methylquinolinones 1 with aromatic and heteroaromatic compounds 2. An unusual photocoupling product 4 was obtained in the photolysis of 3‐iodo‐1‐methylquinolinone in the presence of benzene. The structure of 4 was unequivocally established by an X‐ray crystallographic analysis.
Identification of some isomeric 3,5‐unsymmetrically substituted 1‐aroyl‐pyrazole derivatives by NMR spectroscopy
Authors: Mitkidou Sophia , Papadopoulos Stelios , Stephanidou‐Stephanatou Julia 
Published: March 2009

AbstractThe 1H and 13C nmr chemical shifts are used for the structural assignment of isomeric 1‐aroyl‐4,5‐dihydro‐5‐hydroxy‐4,4‐dimethyl‐1H‐pyrazoles 1 unsymmetrically substituted with phenyl or methyl in the 3,5‐positions of the pyrazole ring. The 1H nmr spectra of 1‐aroyl‐ or 1‐acetyl‐4‐methyl‐1H‐pyrazoles 2 are useful in structure elucidation of unsymmetrically 3‐ or 5‐methyl substituted derivatives.
Synthesis of 2‐amino‐2‐deoxo‐5‐deazaflavins and related compounds
Authors: Aoyagi Takeshi , Yanada Reiko , Bessho Kiyoshi , Yoneda Fumio , Armarego W. L. F. 
Published: March 2009

Abstract10‐Alkyl‐2‐amino‐2‐deoxo‐5‐deazaflavins were prepared by the condensation of 2‐amino‐6‐chloro‐5‐formylpyrimidin‐4(3H)‐one with the corresponding N‐alkylanilines. 2‐Amino‐10‐p‐tolyl‐2‐deoxo‐5‐deazaflavin was prepared by the condensation of 2‐amino‐6‐p‐toluidinopyrimidin‐4(3H)‐one with o‐chlorobenzaldehyde. Some reactivities of 2‐aminopyrimidin‐4(3H)‐ones are described.
Synthesis of various 5‐arylsubstituted cytosines
Authors: Peters Dan , Hörnfeldt Anna‐Britta , Gronowitz Salo 
Published: March 2009

AbstractSome Pd‐catalyzed coupling reactions have been evaluated for the synthesis of 5‐substituted cytosines. A large number of 5‐arylcytosines were prepared in good yields by using 2,4‐O,N‐bis‐trimethylsilyl‐5‐iodocytosine with various aryl tin compounds. The use of trimethylsilyl groups proved to be essential for the reaction, attempted coupling of 5‐iodocytosine and 2‐trimethylstannylthiazole was not successful. One convenient alternative, which unfortunately was not successful, would have been to reverse the coupling functionalities and couple commercial arylhalides with 5‐trimethylstannyl‐ or 5‐tributylstannyl‐derivatives or the corresponding 2,4‐O,N‐bis‐trialkylsilylcytosines.
Reactivity of 3‐alkyl‐4‐arylazomethylene‐3,4‐dihydro‐1,2,3‐benzotriazines in protic solvents: 1,4‐Addition reactions and dimroth rearrangement
Authors: Vaughan Keith , LaFrance Ronald J. , Tang York , Hooper Donald L. 
Published: March 2009

Abstract3‐Alkyl‐4‐arylazomethylene‐3,4‐dihydro‐1,2,3‐benzotriazines 5a and 5b undergo facile 1,4‐addition of methanol or ethanol to afford stable crystalline hydrazones, 6 and 8 which have been characterised by spectroscopic analysis. In particular, the nmr spectrum of 8 shows novel features due to the diastereotopic nature of the CH2 protons in the two O‐ethyl groups. Compound 5b shows a property unique to the compounds in this series; refluxing this arylazomethylenetriazine in ethanol affords a rearranged product, characterised as the 1‐aryl‐2‐cinnolinylhydrazine (9). The formation of 9 is rationalised as a ring opening‐ring closure process analogous to the Dimroth rearrangement. The cinnoline 9 displays some novel chemistry arising from the facility of the arylhydrazino substituent to react with acid to give a fragmentation product, 3‐methylindazole (7).
Condensation of homophthalic anhydrides with heterocyclic imines and DMAD under mild conditions
Authors: Smith Forrest T. , Atigadda Ram V. 
Published: March 2009

AbstractCondensation of 7‐methoxyhomophthalic anhydride with 2‐imidazoline, 2‐thiazoline, 2‐oxazoline, 1‐pyrroline trimer and DMAD (with triethylamine) occurs rapidly under mild conditions.
On the boulton‐katritzky rearrangement of 5,6‐ and 6,7‐Dimethoxy‐4‐nitrobenzofuroxans: A reinvestigation
Authors: Takakis Ioannis M. , Hadjimihalakis Phaedon M. 
Published: March 2009

Abstract5,6‐Dimethoxy‐4‐nitrobenzofuroxan (6) or its 6,7‐isomer 7 equilibrate on heating to a 66:34 = 6:7 thermostationary mixture, in contrast to a previous report. The systems 6:7 and 1f:2f are compared.
Amino acids in the synthesis of heterocyclic compounds. Transformations of thiazolones into imidazole derivatives
Authors: Copar Anton , Stanovnik Branko , Tisler Miha 
Published: March 2009

Abstract5(4H)‐Thiazolone derivative 4, obtained from N‐dithiocarbobenzoxyglycine (1) and N,N‐dimethyl‐N′‐heteroarylformamidines 3 in acetic anhydride, was rearranged with sodium methoxide in methanol followed by acidification with acetic acid into imidazole‐4‐carboxylic acid derivatives 5, 6 and 7. These were further converted with methyl iodide into methylthio derivatives 8, with hydrogen peroxide into the corresponding disulphide 9, with hydrazine and amines into hydrazide 10 and amides 11. In the reactions of 4a and 6a with amines in the presence of dichloromethane symetrically disubstituted methanes 14–18 were formed.
Assembled systems [X‐azolopyridine][quinoline]. Bases and salts
Authors: Savarino Piero , Viscardi Guido , Barni Ermanno , Di Modica Gaetano , Montoneri Enzo , Quagliotto Pierluigi 
Published: March 2009

AbstractA series of bases containing X‐azolopyridines (X = O, NH) and methylquinolines, assembled in different ways, was prepared by reaction of methylquinolinecarboxylic acids (or carboxamides) with diamino (or hydroxyamino) pyridines. The bases were quaternized with methyl iodide. The physical and spectroscopic data of both the bases and the salts were correlated and compared with those of [X‐azolopyridine][pyridine] systems previously studied. The structure of the salts was markedly influenced by a balance of basicity‐hindrance factors in the heteroaromatic substrates.
Structure determination of some 5,6‐dihydropyrrolo‐[1,2‐a][3,1,6]benzothiadiazocines
Authors: Cobb J. , Demetropoulos I. N. , Skoulika S. , Varvounis G. , Aubry A. 
Published: March 2009

AbstractThe conformation of compounds 1 and 2 has been determined in the solid state by X‐ray crystallography and in solution by nmr spectroscopy. MM2 and molecular dynamics calculations were used to determine the conformation of compound 2 in vacuo and in solution.
Crystallographic analysis of a pair of isolable atropisomers of 2‐aryl substituted indoline derivatives
Authors: Eto Masashi , Harano Kazunobu , Hisano Takuzo , Kitamura Takeo 
Published: March 2009

AbstractThe crystal and molecular structures of isomeric compounds of 1‐(4′‐chlorobenzoyl)‐2‐(2″‐hydroxynaphthyl)‐3,3‐Dimethylindoline have been determined by single crystal X‐ray analyses as a pair of diastereomeric atropisomers due to restricted rotation about a Csp3‐Csp2 bond.
Oxidative halogenation of substituted pyrroles with Cu(II). Part III. Bromination and chlorination of 2‐benzoylpyrrole
Authors: Petruso S. , Caronna S. 
Published: March 2009

AbstractThe bromination of 2‐benzoylpyrrole with copper(II) bromide in the homogeneous and the heterogeneous phase is described, giving 4‐ and 5‐monobromo derivatives whose ratio decreases as the temperature is increased. The same reaction with copper(II) chloride in acetonitrile at 60° produces 5‐chloro‐2‐benzoylpyrrole as the major product. 4,5‐Dihalopyrroles in good yields are obtained with an excess of halogenating agent.
Halovinylsulfones 4. Synthesis and some reactions of 2‐phenylsulfonyl‐2‐propenyl isothiocyanate
Authors: Yamamoto Iwao , Kajiwara Kouji , Fujimoto Tetsuya , Ohta Kazutika 
Published: March 2009

AbstractThe title compound, isothiocyanate 2, was obtained in good yield from the reaction of α‐chloromethylvinyl‐sulfone 1 with lead thiocyanate. The isothiocyanate 2 was reacted with aromatic amines to give 2‐amino‐5,6‐dihydro‐4H‐1,3‐thiazines 3 in good to moderate yields. The formation pathways are discussed.
Spectroscopic study of 3‐methyl‐2,4‐diphenyl‐3‐azabicyclo[3.3.1]nonan‐9‐α(β)‐ols
Authors: Iriepa I. , Gil‐Alberdi B. , Galvez E. 
Published: March 2009

Abstract3‐Methyl‐2,4‐diphenyl‐3‐azabicyclo[3.3.1]nonan‐9‐α(β)‐ols have been synthesized and studied by ir, 1H and 13C nmr spectroscopy. In deuteriochloroform and perdeuteriobenzene solutions, these compounds adopt a flattened chair‐chair conformation in which the cyclohexane ring is more flattened.From the 1H and 13C nmr data, several stereoelectronic effects have been deduced. The complete and unambiguous assignment of all protons of the 3‐azabicyclo[3.3.1]nonane system, not described up to date, has been carried out.
Pyrrolization processes of vinyl substituted imidazo[1,2‐a]pyridine, pyrimidine and 1,8‐naphthyridine
Authors: Chavignon O. , Teulade J. C. , Madesclaire M. , Gueiffier A. , Blache Y. , Viols H. , Chapat J. P. , Dauphin G. 
Published: March 2009

AbstractA general synthesis for the preparation of a series of N‐bridgehead compounds: pyrroloimidazopyridine, pyrimidine and naphthyridine has been developed beginning with azidovinyl compounds with thermolytic or photochemical methods
New synthesis of 5‐amino‐5‐deazaflavin derivatives by direct coupling of 5‐deazaflavins and amines
Authors: Kimachi Tetsutaro , Yoneda Fumio , Sasaki Takuma 
Published: March 2009

Abstract5‐Amino‐5‐deazaflavin derivatives are newly synthesized by direct coupling of 5‐deazaflavins and amines. Some of them revealed potential activity toward tumor cells such as L1210 or KB cells.
Synthesis of quinazoline derivatives through anionic cycloaddition reactions of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate with acetylenes and olefins
Authors: Wada Akimori , Yamamoto Hiromi , Ohki Kazuhiro , Nagai Sotoo , Kanatomo Shoichi 
Published: March 2009

AbstractThe anionic cycloaddition of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate has been investigated. The lithium salt of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate, generated by deprotonation with lithium diisopropylamide in ether at – 70°, reacted smoothly with electron deficient acetylenes and olefins to give quinazoline derivatives in a single step.
Axially chiral heteroaromatics. 1. Preparation of optically active 1,1′‐biisoquinoline N,N'‐dioxide
Authors: Fujii Masayuki , Honda Akihiro 
Published: March 2009

AbstractA novel optically active heteroaromatic compound, (+)‐1,1′‐biisoquinoline N,N′‐dioxide (1) and its atropisomer (‐)‐1 were prepared and characterized by several spectroscopic methods.
Novel routes to 1‐aryl‐1,4‐dihydro‐3(2H)‐isoquinolinones and 2‐substituted or 2,3‐disubstituted benzofurans by intramolecular cyclizations
Authors: Katritzky Alan R. , Lan Xiangfu , Zhang Zhongxing 
Published: March 2009

AbstractN‐(α‐Benzotriazolylalkyl)arylacetamides, readily available from an arylacetamide, an aldehyde and benzotriazole, undergo intramolecular cyclization under acidic conditions to give 1‐aryl‐1,4‐dihydro‐3(2H)‐isoquinolinones in good to excellent yields. Similarly, 2‐(benzotriazol‐1‐yl)‐2‐(o‐hydroxyphenyl)ethanols, obtained by lithiation of 2‐(benzotriazol‐1‐ylmethyl)phenols followed by quenching with aldehydes or ketones, eliminate a molecule of water and a molecule of benzotriazole yielding 2‐substituted and 2,3‐disubstituted benzofurans.