bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clear cell variant of calcifying epithelial odontogenic tumor: Case report and review of the literature
Authors: Hicks M. John , Flaitz Catherine M. , Wong Mark E. K. , McDaniel R. Keith , Cagle Philip T. 
Published: February 2007

AbstractThe calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm which was first described by Pindborg in 1955 and accounts for less than 1% of all odontogenic lesions. Recently, a clear cell variant of CEOT has been identified with only eight well‐documented cases in the literature. We present an additional case of clear cell CEOT of the mandible and review the salient clinical, radiologic, and histopathologic features of this entity and CEOTs in general. The differential diagnosis of clear cell tumors in the mandible includes: clear cell odontogenic tumor, clear cell ameloblastoma (odontogenic carcinoma), metastatic clear cell adenocarcinoma, primary intraosseous mucoepidermoid carcinoma, acinic cell carcinoma, epithelial‐myoepithelial carcinoma, clear cell salivary gland tumors, and clear cell variant of squamous cell carcinoma. Because of the belief that clear cell odontogenic tumors are locally aggressive neoplasms, definitive resection of the entire mass with tumor‐free surgical margins and long‐term follow‐up are recommended. © 1994 John Wiley & Sons, Inc.
Angiomyolipoma of the nasal cavity: Case report and review of the literature
Authors: Gatalica Zoran , Lowry Louis D. , Petersen Robert O. 
Published: February 2007

AbstractAn unusual localization of intranasal angiomyolipoma is described in an adult male patient with no signs of tuberous sclerosis. The lesion was composed of mature fat cells, vascular spaces with lack of elastic tissue, and presence of bundles of mature smooth muscle cells. Antibodies to intermediate filaments revealed presence of vimentin and absence of desmin in both smooth muscle bundles and in vessel walls. A review of the literature has shown that this is only the third reported case of the angiomyolipoma of the nasal cavity, and some important differences between this entity and renal angiomyolipoma are described. © 1994 John Wiley & Sons, Inc.
Pearson near‐total laryngectomy: A reproducible speaking shunt
Authors: Levine Paul A. , Debo Richard F. , Reibel James F. 
Published: February 2007

AbstractBackground. Since 1980, Pearson and his associates at the Mayo Clinic have accrued an increasing number of patients whom they have treated with what is now designated as a “near‐total” laryngectomy rather than a total laryngectomy. Despite the positive reports of the value of this procedure in providing speech by an internal shunt, the use of this total laryngectomy alternative has not gained wide acceptance. We report our experience with treating 11 patients during a 3‐year period using the near‐total laryngectomy.Methods. Between September 1989 and September 1992, 11 patients with the following anatomic lesions were offered and accepted the option of the near‐total laryngectomy: (1) T3 or early T4 glottic squamous cell carcinoma that did not involve the interarytenoid space or the vocal process of the opposite arytenoid; (2) T3 supraglottic squamous cell carcinoma with a fixed vocal cord in which a supraglottic laryngectomy could not be performed; (3) T2, T3 pyriform sinus squamous cell carcinomas; (4) radiotherapy failure early glottic lesions in which a vertical hemilaryngectomy for salvage was not able to be performed and met the requirements in (1); and (5) large hypopharyngeal lesions in which the larynx would be sacrificed to prevent aspiration but was not involved with tumor.Results. Nine of 11 patients (82%) attained successful speech in an average of 5.3 months. Two of the 11 patients required a completion laryngectomy, both due to wound complications. All but two of the patients received postoperative radiotherapy. Of the nine successful speakers, five have had an occasional droplet of fluid through the shunt; three have been on a permanent basis and two transient. Eighty‐nine percent of the speaking patients (8 of 9) are alive without disease, a mean of 25.5 months after therapy completion.Conclusions. The near‐total laryngectomy can be performed outside the Mayo Clinic with creditable results, with 82% of the patients attaining successful speech, an average of 5.3 months postoperatively. Eighty‐nine percent of the speakers have had a mean disease‐free survival of 25.5 months. Analysis of larger series from multiple institutions in conjunction with voice analyses of these patients compared to those with tracheoesophageal punctures is needed to confirm our initial enthusiasm for this procedure. © 1994 John Wiley & Sons, Inc.
Sternocleidomastoid myofascial flap for head and neck reconstruction
Authors: Alvi Aijaz , Stegnjajic Arsen 
Published: February 2007

AbstractBackground. The use of the sternocleidomastoid (SCM) muscle in the repair of soft tissue defects arising after surgery for neoplasms of the head and neck has been a subject of controversy. We describe a variant of the SCM muscle flap called the “SCM myofascial flap” and report our experience with this flap in head and neck reconstruction.Methods. Six patients underwent head and neck reconstruction with the SCM myofascial flap. The head and neck defects included partial laryngeal, pharyngeal defects, and concave soft tissue neck defects after resection.Results. Follow‐up of the patients ranged from 6 to 91 months. In the case of laryngeal and pharyngeal reconstruction, all had a good voice and were able to eat by mouth without aspiration. Two of the four patients were decannulated. The only complication was a laryngocutaneous fistula.Conclusion. We have used this flap with success, in soft tissue augmentation and in laryngeal and pharyngeal reconstruction following tumor resection. The technique and the results of our experience are discussed. We believe that in selected cases, the SCM myofascial flap is ideal for reconstruction of head and neck defects. © 1994 John Wiley & Sons, Inc.
Carcinoma of the oral tongue: A comparison of results and complications of treatment with radiotherapy and/or surgery
Authors: Fein Douglas A. , Mendenhall William M. , Parsons James T. , McCarty Patricia J. , Stringer Scott P. , Million Rodney R. , Cassisi Nicholas J. 
Published: February 2007

AbstractBackground. Oral tongue cancer may be treated primarily with radiotherapy or with surgery alone or combined with adjuvant radiotherapy: the choice between these two approaches is controversial.Methods. To evaluate the results of a shift in treatment policy in 1985 in favor of primary surgical treatment for carcinoma of the oral tongue, the results of radiotherapy (with or without neck dissection, 105 patients) were compared with those for surgery (with or without radiotherapy, 65 patients).Results. Local control rates were improved for T3 (p = .03) and T4 (p = .08) patients treated surgically but were similar for T1‐T2 patients. Local‐regional control and survival rates were not significantly different. The rate of severe complications was significantly higher (p = .01) for T3 patients treated with surgery, particularly in the subset of patients who received postoperative radiotherapy.Conclusions. We generally recommend surgical treatment for T1‐T2 patients with the addition of postoperative twice‐a‐day radiotherapy in selected cases. For selected T3‐T4 patients we are investigating split‐course twice‐a‐day preoperative radiotherapy in the hope that the extent of the surgical procedure, and hence the rate of severe complications, will be reduced. © 1994 John Wiley & Sons, Inc.
Squamous cell carcinoma arising in recurrent odontogenic keratocyst: Case report and literature review
Authors: Dabbs David J. , Schweitzer Robert J. , Schweitzer Laurie E. , Mantz Fred 
Published: February 2007

AbstractBackground. Keratinizing odontogenic cysts of the mandible commonly have an aggressive clinical course, marked by multiple recurrences. Primary intraosseus carcinoma (PIOC) of the mandible is rare, and when it occurs it is often found to be arising in or closely associated with some type of cystic structure.Methods. A patient with squamous cell carcinoma arising from an odontogenic keratocyst is studied clinically, radiographically, and pathologically.Results. The patient who was documented to have an odontogenic keratocyst, 1 year later had a squamous carcinoma removed from the recurrent cyst.Conclusion. We report the occurrence of squamous cell carcinoma arising from a recurrent odontogenic keratocyst, which has not previously been documented in the literature. The literature on this subject is reviewed. © 1994 John Wiley & Sons, Inc.
Functional endoscopic sinus surgery for isolated sphenoid sinus disease
Authors: Gilain Laurent , Aidan Didier , Coste André , Peynegre Roger 
Published: February 2007

AbstractBackground. This article reviews 12 cases of isolated sphenoid sinus disease: chronic inflammatory sinusitis (7), mucoceles (2), aspergillus lesions (2), and isolated polyp (1).Methods. Criteria for diagnosis were based on clinical symptoms, nasal endoscopic evaluation, and computed tomography (CT). Magnetic resonance imaging was used only in cases of bone erosion and when patients presented with vision problems. All patients were treated by functional endoscopic sphenoidotomy. Any postoperative complications were noted.Conclusion. The reported good results, on the basis of regression of functional symptoms and with nasal endoscopic and CT evaluation, suggest that intranasal sphenoidotomy under endoscopic control is a safe and effective method of treatment of nonmalignant isolated sphenoid disease. The mean follow‐up is 26 months. © 1994 John Wiley & Sons, Inc.
Occult distant metastases of well‐differentiated thyroid carcinoma
Authors: Zohar Yuval , Strauss Michael 
Published: February 2007

AbstractBackground. The tendency of well‐differentiated thyroid carcinoma to remain localized and its slow progression have supported the belief that this disease behaves as a low‐grade malignancy. Consequently, a conservative approach in the management of the well‐differentiated thyroid carcinoma has existed during the years. Occult distant metastases of thyroid cancer is an occasional finding considered of ominous significance.Methods. In a retrospective study, we reviewed the records of 187 adult patients with well‐differentiated thyroid carcinoma treated by total thyroidectomy. These cases were found among 1,240 thyroidectomies performed in our department between 1982 and 1993. Occult distant skeletal and lung metastases disclosed by total body131I scans, after total thyroidectomy, were present at the time of initial treatment in 11 patients (11/187). This group included 9 women and 2 men ranging in age from 36 to 70 years, with a mean age of 47 years. Seven patients had papillary carcinoma, whereas follicular malignancy was found in four. Review of the surgical specimens showed total involvement of the gland in 5 cases, with extracapsular tumoral spread in 3 patients. Multicentric disease was present in 6 specimens. Patient follow‐up revealed a mortality rate of 64% (7/11) during the first 3 postoperative years.Conclusions. Analysis of this population confirms that well‐differentiated thyroid carcinoma with distant metastases is an aggressive disease with lethal consequence. Early detection and therapy of occult distant metastases present at the time of initial treatment is possible only after total thyroid ablation, because otherwise the radioactive iodine is trapped by the gland's remnants. © 1994 John Wiley & Sons, Inc.
Topical bleomycin treatment of oral leukoplakia: A randomized double‐blind clinical trial
Authors: Epstein Joel B. , Wong Frances L. W. , Millner Amelia , Le Nhu D. 
Published: February 2007

AbstractBackground. Oral leukoplakia and oral erythroplakia may be associated with benign and dysplastic cellular changes, and are at risk of malignant transformation. Additional means of management of these lesions is needed. The results of nonblinded trials using topical bleomycin in oral leukoplakia indicated the need for phase III study.Methods. A prospective, double‐blind, randomized trial of topical bleomycin versus placebo was conducted. Bleomycin 1% in dimethylsulphoxide (DMSO) or the carrier was applied for 5 minutes for 14 consecutive days. Clinical assessment and pre‐application and post‐treatment biopsies were conducted.Results. Twenty‐two patients were randomized. Of the patients who received bleomycin, decrease in clinical size of the lesion was achieved (p = 0.001), and histological reduction in dysplasia was seen (p = 0.094).Conclusions. The topical application of bleomycin in DMSO may represent an additional approach to management of oral leukoplakia. The treatment is well‐tolerated, and may be considered when the location or extent of the lesion may make surgical excision difficult. © 1994 John Wiley & Sons, Inc.
Precancerous lesions of the larynx: Clinical and pathologic correlations and prognostic aspects
Authors: Cuchi Asunción , Bombi José A. , Avellaneda Ramón , Cardesa Antonio , Traserra José 
Published: February 2007

AbstractBackground.Medical literature on the development of malignancy shows wide‐ranging limitations depending on the criteria considered, but all authors agree that the presence of dysplasia in the sample is an important prognostic sign.Method.This is a retrospective study of 248 patients controlled and treated at the ENT and Pathology Departments of the Hospital Clinic in Barcelona between 1981 and 1991 for larynx lesions. Biopsy studies of the following pathologic entities were carried out: keratosis, chronic inflammation, and papilloma of the adult. The degree of dysplasia present in each sample was assessed.Results.The overall percentage of malignancy was 15.6% in this series. Malignancy developed in 8.7% of the cases without dysplasia and in 31% (p < 0.0001) with dysplasia. The groups were correlated with gender, age, and smoking habit. The presence of epithelial dysplasia is an important prognostic factor. The risk of malignant transformation increases if the dysplasia occurs in smokers.
Assessment of cryoprecipitate‐thrombin solution for dural repair
Authors: Wiegand David A. , Hartel Maria I. , Quander Troy , Latz Barbara , Dankle Jon A. 
Published: February 2007

AbstractBackground. After resection of cranial and skull base tumors, fibrin‐thrombin solutions can provide a temporary biologic seal of dural closures until final healing occurs. We investigated several variables affecting the strength of these „tissue glues”︁ for repair of dural defects using in vitro methods to model clinical repairs.Methods. The competence of human cryoprecipitate‐thrombin (CPT) „tissue glues”︁ in providing a watertight seal for patched rat fascia and human cadaveric dural defects was assessed. A saline column was fabricated to allow for controlled pressure (up to 700 mm) to be applied over an open aperature containing the repaired defect. Variables of repair included time after repair, defect size, and mixing temperature.Results. Wide variations in the strength of different cryoprecipitate glues were found. Time allowed after repair did not significantly affect the repair strength. Cooling the components of the glue solution prior to mixing significantly increased repair strength. Similar results were found for different defect sizes.Conclusions. Under controlled in vitro conditions, integrity of fibrin glue repairs varied widely. This was not attributable to differences in solution fibrinogen concentration. Cooling the „tissue glue”︁ components prior to mixing significantly increased repair strength of patched tissue defects.
Craniofacial resection at the university of Virginia (1976‐1992): Survival analysis
Authors: Levine Paul A. , Debo Richard F. , Meredith Scott D. , Jane John A. , Constable William C. , Cantrell Robert W. 
Published: February 2007

AbstractBackground.The purpose of this study is to evaluate the survival of patients treated at the University of Virginia Health Sciences Center with an anterior craniofacial resection in conjunction with radiotherapy and/or chemotherapy for malignancies of the superior sinonasal cavity. In addition, the impact of aggressive salvage therapy for patients with recurrent disease is considered.Methods.Between June 1976 and December 1992, a total of 45 patients underwent a craniofacial resection by the Departments of Otolaryngology‐Head and Neck Surgery and Neurological Surgery at the University of Virginia. One patient was excluded from the analysis because his neoplasm was benign. Another patient died 2 days postoperatively from multiple strokes. The remaining 43 patients were divided into two subgroups: (1) patients with esthesioneuroblastoma (24 patients) and patients with non‐esthesioneuroblastoma malignancies (19). Their survival curves were estimated for the percent survival free of disease by month of follow‐up using the product limit of Kaplan and Meier. In addition, the salvage treatment for recurrences was examined for both groups.Results.The 5‐year disease‐free survival rate for the entire group was 77%, with a 2.3% postoperative mortality. The 5‐year disease‐free survival for the esthesioneuroblastoma patients was 90%, and that for the non‐esthesioneuroblastoma group was 59.1% (p= 0.028). Four of 8 esthesioneuroblastoma patients who recurred and were treated with aggressive salvage therapy were without evidence of disease 5 years after completion of therapy, and 3 of the 10 nonesthesioneuroblastoma patients salvaged were without evidence of disease 57.3 months after therapy (39% surgical salvage).Conclusions.There is a statistically significant difference between the 5‐year disease‐free survival for the esthesioneuroblastoma patients and the non‐esthesioneuroblastoma patients (90% vs 59.1%;p= 0.028), and aggressive salvage therapy appears to be a more successful option in the esthesioneuroblastoma group of patients.
Squamous cell carcinoma arising in Hashimoto's thyroiditis
Authors: Chaudhary Rekha K. , Barnes E. Leon , Myers Eugene N. 
Published: February 2007

AbstractThe case of a 76‐year‐old white woman with squamous cell carcinoma of the thyroid gland arising in a background of Hashimoto's thyroiditis is presented. Squamous cell carcinoma of the thyroid gland is a very rare and aggressive tumor, and only a few cases are reported as arising in Hashimoto's thyroiditis. Although Hashimoto's thyroiditis alone does not necessarily predispose patients to malignancy, the finding of a prominent nodule in such a patient should suggest the possibility of malignancy, and an aggressive search and treatment regimen, including surgical intervention, should be pursued.
Anaplastic carcinoma of the thyroid: A 24‐year experience
Authors: Tan Raymond K. , Finley Robert K. , Driscoll Deborah , Bakamjian Vahram , Hicks Wesley L. , Shedd Donald P. 
Published: February 2007

AbstractBackground.Anaplastic carcinoma of the thyroid gland is a lethal entity; few patients live more than 12 months following diagnosis. We retrospectively reviewed the experience with this entity at our cancer institute and identified a subgroup of patients with complete resection who have a 60% 5‐year survival.Methods.Twenty‐one cases of anaplastic carcinoma of the thyroid gland were analyzed retorspectively with respect to prognostic factors influencing survival. This represents 2.7% of 771 cases of thyroid cancer seen at our institution from 1968 to 1992. The median age at presentation was 65.1 years; male/female ratio was 1:1.1; and the most common symptom was a rapidly enlarging neck mass (76%).Results.Estimated 5‐year survival was 10% (median: 4.5 months). Tumor size less than 6.0 cm (p= .004) and female gender (p= .02) were significant prognostic factors. Five patients who underwent complete resection had an estimated 5‐year survival of 60% (median: 131 months). Four of these patients had postoperative radiotherapy with or without sequential chemotherapy. Two of these patients survived more than 10 years, and a third remains alive without disease at 26 months.Conclusions.Complete resection and multimodality therapy result in long‐term survival for a subgroup of patients with anaplastic thyroid carcinoma. © 1995 Jons Wiley & Sons, Inc.
Bilateral chylothorax following neck dissection
Authors: Jabbar Alaa S. Abdul , Al‐Abdulkareem Abdulmajeed 
Published: February 2007

AbstractBackground: Bilateral chylothorax, as a complication of neck dissection, is extremely rare, and was first described in 1907. Ten cases are reported in the literature.Methods. This presentation illustrates an additional case of bilateral chylothorax occurring after neck dissection. Anatomic and physiologic considerations are presented and possible mechanisms of pathogenesis are discussed.Results. Chylothorax has two major complications: respiratory and metabolic. The modern concepts of treatment are summarized.Conclusions. After neck dissection, the clinician should suspect chylothorax if the patient had respiratory embarrassment and an abnormal chest x‐ray postoperatively. © 1995 Jons Wiley & Sons, Inc.
Free jejunal interposition reconstruction after pharyngolaryngectomy: 201 consecutive cases
Authors: Theile David R. , Robinson David W. , Theile David E. , Coman William B. 
Published: February 2007

AbstractBackground. Reconstruction of tubular defects following pharyngolaryngectomy has required complicated surgery with high perioperative morbidity and mortality. Free jejunal interposition provides an excellent reconstruction with potential for lower immediate complications and better long‐term results than other procedures.Methods. A total of 201 consecutive free jejunal interpositions were performed following pharyngolaryngectomy between 1977 and 1993. Operative details, complications, and outcome were prospectively documented.Results. Perioperative mortality was low (4.5%) and microvascular success rate high (97%), although a small number of late failures were recorded. Average time until swallowing postoperatively was 11 days, and 92% of patients could maintain full nutrition. Voice rehabilitation was mentioned, and increasingly good results are being obtained.Complication rates for the neck (17%) and the abdomen (2.5%) were also low. There were no problems with excess mucus production or reflux. Radiation effect on the jejunal conduit was not detrimental to long‐term patency of the vascular anastomoses or to function as a conduit.Conclusions. Comparison with other published techniques permits the contention that a free jejunal interposition is the reconstruction of choice after pharyngolaryngectomy. © 1995 Jons Wiley & Sons, Inc.