bluuebunny/crossref_metadata_2025_split huggingface dataset:
An affordable and green voltammetric approach for the determination of sotalol in biological, environmental, and pharmaceutical samples
Authors: Fix Gustavo , Coldibeli Bruna , Sartori Elen Romão 
Published: March 2024

AbstractThis work outlines the development of a voltammetric method for a sensitive, rapid, and environmentally friendly determination of the antihypertensive sotalol (SOT) in several sample types employing the anodically pretreated boron‐doped diamond electrode. Cyclic voltammograms of SOT presented a well‐defined irreversible oxidation peak at 1.21 V (Ag/AgCl (3.0 mol L−1 KCl)) in Britton–Robinson buffer solution (pH 3.0). Figures of merits recommended by the validation guidelines were evaluated for the validation of the present method. Employing differential pulse voltammetry linearity of SOT was obtained in the concentration range of 0.39–4.22 μmol L−1 in 0.1 mol L−1 H2SO4 solution, with a limit of detection of 0.031 μmol L−1. The selectivity of the method was assessed against interferers and show relative standard deviation (RSD) values lower than 6 %. Recovery tests yielded percentages ranging from 93 % to 96 % in urine sample and from 100 % to 107 % in tap water sample. The proposed method was successfully applied in pharmaceutical, environmental, and biological samples offering a suitable green analytical chemistry profile.
A novel design strategy of track‐based asymmetric nonlinear energy sink for seismic response mitigation of structures
Authors: Wang Jingjing , Zheng Yuqiang 
Published: March 2024

AbstractMass dampers, whether linear or nonlinear, rely on resonance with the structure to achieve optimal control performance. However, linear mass dampers require frequency tuning, while nonlinear mass dampers are sensitive to input energy levels, rendering both inadequate for control problems that involve frequency and energy uncertainties. To address this issue, the track asymmetric nonlinear energy sink (TANES) has been developed as a robust mass damper against frequency and energy changes. In this study, a novel design strategy consisting of physical and parameter design was proposed for TANESs. First, TANESs with inverted tracks as the auxiliary mass were proposed, resulting in a significant reduction in the dimensions and weight of the device. The new physical design was then realized, and the mathematical descriptions of the TANES system were validated through experiments on a two‐story frame structure. Subsequently, a parameter design method was proposed to match the frequency variation pattern of the TANES with the given structural and load conditions. Following the design procedure, three TANESs with markedly different track shapes were obtained and compared with existing mass dampers under different types of excitations. Results showed that the frequency responses of the TANES systems subjected to harmonic ground excitations shared great similarity with those of a well‐tuned TMD system at small‐to‐moderate energy levels. As the energy level increased, nonlinear responses such as strongly modulated responses were observed in the TANES systems with decrease structural frequencies, which significantly reduced the resonant peak in the frequency responses. The frequency responses of the TANES systems were consistent with the design objective and could be used to quantitatively predict the robustness performance of the devices under impulsive and seismic excitations. With the reduced dimensions and weight resulting from the inverted‐track configuration and the robustness performance in line with common structural and load conditions, the proposed design strategy of TANESs demonstrated great potential in the seismic response mitigation of engineering structures.
Investigating the energy storage performance in optimal design of a solar hybrid multi‐generation system with distillatory
Authors: Forghani Amir Hossein , Hajabdollahi Hassan , Solghar Alireza Arab 
Published: March 2024

AbstractIn this study, a cogeneration system of heating, cooling and power used with the solar flat plate collectors (FPCs) and photovoltaic panels (PVs) integrates with a multi‐effect distillation through thermal vapor compression (MEE‐TVC), investigated as the first system to meet the loads of heating, cooling, electricity and fresh water. As an innovation, the combination of the first system with cooling and thermal storage tanks have been investigated. The systems are optimized with MATLAB and single‐objective genetic algorithm. The total annual cost considered as the objective function to compare the two systems and 36 and 61 design variables are obtained for the first and second systems, respectively. The design parameters considered for optimization included the capacity of the diesel engine as the prime mover, electrical chiller capacity, absorption chiller capacity, size of the boiler, partial loads of the diesel engine for each hour of the 2 days (1 day for hot months and 1 day for cold months), partial loads of the chillers for each hour of the first days (second day has no cooling load), number of FPCs and PVs, number of effects in the desalination unit, driving steam pressure, feed water flow rate, driving steam flow rate, and electric cooling ratio. The optimization aimed to fulfill the heating, cooling, electricity, and fresh water requirements of a residential town situated in Bandar Abbas, Hormozgan province, Iran. The second system's optimization results were compared with first system. The results have shown that the objective function for the first system was and the initial investment cost was , and for the second system the objective function was and the initial investment cost was . Therefore, by using energy storage, the objective function was reduced by 11.30%.
Escherichia coli isolates from vegetable farms in Addis Ababa, Ethiopia: Antimicrobial susceptibility profile and associated resistance genetic markers
Authors: Hailu Woinshet , Alemayehu Haile , Hailu Lulit , Medhin Girmay , Rajashekara Gireesh , Gebreyes Wondwossen A. , Eguale Tadesse 
Published: March 2024

AbstractThe use of animal manure to fertilize soil is an emerging concern contributing to the transfer of antimicrobial‐resistant pathogens to vegetables. Hence, assessing antimicrobial susceptibility profile of Escherichia coli in vegetable farms is essential to design appropriate interventions against antimicrobial resistance (AMR) in the food chain. This study assessed antimicrobial resistance profile and associated genetic markers among E. coli isolated from vegetable farms fertilized with animal manure in Addis Ababa, Ethiopia. A total of 1044 samples were collected using convenience sampling: soil (n = 271), manure (n = 375), and vegetables (n = 398) from 81 vegetable farms in Addis Ababa, Ethiopia. Antimicrobial susceptibility test was conducted for 100 E. coli isolates and antimicrobial resistance genes (ARGs) were tested by polymerase chain reaction (PCR). Of the 1044 collected samples, 25.3% were positive for E. coli, with significantly higher prevalence in the manure sample and samples collected from Akaki Kality sub‐city (p < .05). The highest resistance rate was recorded for tetracycline (72%), followed by streptomycin (63%), and sulfamethoxazole +trimethoprim (56%). Multidrug resistance was detected in 61% of the E. coli isolates. The aac(3)‐IV (76.9%), bla TEM (65.4%), aadA (60.3%), tet(A) (58.3%), and sulI (51.7%) were the commonly detected resistance genes. The current study showed a high burden of antimicrobial resistance among E. coli isolated from manure‐amended vegetable farms, with potential of playing a significant role in the dissemination of antimicrobial resistance in the food chain. Efforts should be made to reduce the burden of resistant organisms and ARGs through prudent use of antimicrobials in livestock and application of appropriate composting techniques before using manure as fertilizer.
The infant health effects of doulas: Leveraging big data and machine learning to inform cost‐effective targeting
Authors: Peet Evan D. , Schultz Dana , Lovejoy Susan , Tsui Fuchiang (Rich) 
Published: March 2024

AbstractDoula services represent an underutilized maternal and child health intervention with the potential to improve outcomes through the provision of physical, emotional, and informational support. However, there is limited evidence of the infant health effects of doulas despite well‐established connections between maternal and infant health. Moreover, because the availability of doulas is limited and often not covered by insurers, existing evidence leaves unclear if or how doula services should be allocated to achieve the greatest improvements in outcomes. We use unique data and machine learning to develop accurate predictive models of infant health and doula service participation. We then combine these predictive models within the double machine learning method to estimate the effects of doula services. We show that while doula services reduce risk on average, the benefits of doula services increase as the risk of negative infant health outcomes increases. We compare these benefits to the costs of doula services under alternative allocation schemes and show that leveraging the risk predictions dramatically increases the cost effectiveness of doula services. Our results show the potential of big data and novel analytic methods to provide cost‐effective support to those at greatest risk of poor outcomes.
Current progress and future perspectives in total‐body PET imaging, part I: Data processing and analysis
Authors: Sun Tao , Chen Ruohua , Liu Jianjun , Zhou Yun 
Published: March 2024

AbstractTotal‐body positron emission tomography (TB‐PET) has ultra‐high sensitivity and the unique ability to conduct dynamic imaging of the entire body. Both the hardware configuration and the data acquired from a TB‐PET scanner differ from those of the conventional short axial field‐of‐view scanners. Therefore, various aspects concerning data processing need careful consideration when implementing TB‐PET in clinical settings. Additionally, advances in data analysis are needed to fully uncover the potential of these systems. Although some progress has been achieved, further research and innovation in scan data management are necessary. In this report, we provide a comprehensive overview of the current progress, challenges, and possible future directions for TB‐PET data processing and analysis. For a review of clinical applications, please find the other review accompanying this paper.
Saikosaponin d protects pancreatic acinar cells against cerulein‐induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS‐STING pathway
Authors: Chen Hui , Lu Xirong , Xu Beiqi , Cheng Gang , Li Yuyi , Xie Dan 
Published: March 2024

AbstractAcute pancreatitis represents an inflammatory disease featuring pancreatic necrosis and inflammation. Inflammatory injury of pancreatic acinar cells (PACs) is critically involved in the initiation and progression of acute pancreatitis. Pyroptosis, a new kind of programmed cell death concomitant with a low‐grade inflammatory reaction, plays a function in acute pancreatitis pathology. It is unclear whether saikosaponin d (SSd), a pharmacologically active natural product, could protect PACs by regulating pyroptosis. Here, we established a PAC injury model in vitro using cerulein to treat AR42J cells. SSd restored viability and proliferation and lowered the release of pancreatic enzymes and inflammatory interleukins in cerulein‐treated AR42J cells. Cerulein‐induced pyroptosis was evidenced by typical ultrastructural changes and NLRP3/caspase‐1 activation in AR42J cells, but SSd attenuated cerulein‐induced pyroptosis and inhibited NLRP3/caspase‐1 pathway. Mechanically, SSd reduced mitochondrial damage and mtDNA release, and blocked cGAS‐STING signaling in AR42J cells treated with cerulein, contributing to the inhibition of NLRP3‐mediated pyroptosis. Furthermore, SSd abolished cerulein‐elevated oxidative stress in AR42J cells, leading to the mitigation of mitochondrial damage and inhibition of cGAS‐STING signaling and pyroptosis. In conclusion, SSd protected PACs against cerulein‐induced pyroptosis by alleviating mitochondrial damage and inhibiting the cGAS‐STING pathway, and it could be a therapeutic candidate for acute pancreatitis.
Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator
Authors: Lin Wen‐wen , Ou Guan‐yong , Dai Hui‐fang , Zhao Wei‐jiang 
Published: March 2024

AbstractNeuregulin‐4 (Nrg4) and melatonin play vital roles in endocrine diseases. However, there is little discussion about the function and potential mechanism of Nrg4 and melatonin in prolactin (PRL) regulation. The human normal pituitary data from Gene Expression Profiling Interactive Analysis (GEPIA) database was used to explore the correlation between NRG4 and PRL. The expression and correlation of NRG4 and PRL were determined by Immunofluorescence staining (IF) and human normal pituitary tissue microarray. Western Blot (WB) was used to detect the expression of PRL, p‐ErbB2/3/4, ErbB2/3/4, p‐Erk1/2, Erk1/2, p‐Akt and Akt in PRL‐secreting pituitary GH3 and RC‐4B/C cells treated by Nrg4, Nrg4‐small interfering RNA, Erk1/2 inhibitor FR180204 and melatonin. The expression of NRG4 was significantly positively correlated with that of PRL in the GEPIA database and normal human pituitary tissues. Nrg4 significantly increased the expression and secretion of PRL and p‐Erk1/2 expression in GH3 cells and RC‐4B/C cells. Inhibition of Nrg4 significantly inhibited PRL expression. The increased levels of p‐Erk1/2 and PRL induced by Nrg4 were abolished significantly in response to FR180204 in GH3 and RC‐4B/C cells. Additionally, Melatonin promotes the expression of Nrg4, p‐ErbB4, p‐Erk1/2, and PRL and can further promote the expression of p‐Erk1/2 and PRL in combination with Nrg4. Further investigation into the function of Nrg4 and melatonin on PRL expression and secretion may provide new clues to advance the clinical control of prolactinomas and hyperprolactinemia.
Condensed Fukui function and experimental evaluation of the corrosion inhibition properties of some antipyrinyl‐imidazotriazole and their derivatives for copper in an acidic environment
Authors: Elsayed Shymaa Adel , Barghout Nehal A. , Ragab Safaa , Abdel‐Latif Ehab , Etman Hassan Ali , Hamed Mohamed A. , Eddy Nnabuk Okon , El Nemr Ahmed 
Published: March 2024

AbstractThe effectiveness of synthesized antipyrinyl‐imidazotriazole and its derivatives as inhibitors for the corrosion of copper alloy in 0.5 M H2SO4 solution was tested using weight loss, electrochemical impedance spectroscopy (EIS) and potentiodyanmic polarization techniques. The generated results confirmed that the tested compounds have strong inhibition efficiencies for the protection of the corrosion of copper alloy in 0.5 M H2SO4. Maximum inhibition efficiencies (IEs) evaluated from electrochemical measurements at inhibitor's concentrations of 0.040 g/L were 85% (5‐(4‐Antipyrinyl)‐3H‐imidazo[1,2‐b][1,2,4]triazole), 60% (6‐Antipyrinyl‐imidazo[2,1‐b]thiazole) and 72% (2‐Antipyrinyl‐7‐ethoxy‐imidazo[2,1‐b]benzothiazole). It was observed that the inhibition efficiency was strongly influenced by the flow rate of the solution and was reduced to 79 (5‐(4‐Antipyrinyl)‐3H‐imidazo[1,2‐b][1,2,4]triazole), 60% (6‐Antipyrinyl‐imidazo[2,1‐b]thiazole), and 44% (2‐Antipyrinyl‐7‐ethoxy‐imidazo[2,1‐b]benzothiazole) at an agitation speed of 400 rpm. EI from weight loss was comparable with those from PDP of mixed‐type inhibition style and EIS of diffusion model. The low inhibition efficiency for 6‐Antipyrinyl‐imidazo[2,1‐b]thiazole was significantly enhanced from 60% to 90% through a synergistic effect of 0.0001 M KI. The Temkin and Frumkin isotherms indicate the physical adsorption of inhibitors on copper surface. Condensed Fukui function calculations reveal a common center for electrophilic attacks in the three molecules: the nitrogen in the bridged pyrrole rings (labeled as N11).
Examining cognitive disengagement syndrome in a psychiatric outpatient sample: Psychometric support and associations with internalizing symptoms and sleep problems
Authors: Yucens Bengu , Basay Omer , Buber Ahmet , Tumkaya Selim , Kabukcu Basay Burge , Erdem Busra , Becker Stephen P. , Leonard Burns G. 
Published: March 2024

AbstractObjectiveThe internal (structural) and external validity of a self‐report measure of cognitive disengagement syndrome (CDS, formerly sluggish cognitive tempo) relative to a self‐report measure of attention‐deficit/hyperactivity disorder‐inattention (ADHD‐IN) was evaluated with adults from university outpatient psychiatric clinics in Turkey.MethodsA total of 274 outpatients (75.9% women; ages 18–64 years; Mage = 31.06; SDage = 10.84; 50.4% anxiety disorders; 41.6% depressive disorders; 2.9% ADHD; 1.5% sleep disorders; 0.7% eating disorders; 2.9% no mental disorder) completed self‐report measures of CDS, ADHD‐IN, ADHD‐hyperactivity/impulsivity (HI), sleep problems, depression, and stress.ResultsAll 15 CDS symptoms measured by the Adult Concentration Inventory (ACI) showed convergent (moderate to high loadings on the CDS factor) and discriminant (loading close to zero on the ADHD‐IN factor) validity. CDS also showed stronger first‐order and unique associations than ADHD‐IN with sleep problems, depression, anxiety, and stress, whereas ADHD‐IN showed stronger first‐order and unique associations than CDS with ADHD‐HI.ConclusionThis is the first study to provide support for the scores from this 15 item self‐report measure of CDS by the ACI in a clinical sample of adults, with findings consistent with previous studies examining parent and teacher rating scale measures with the same 15 CDS symptoms. These findings provide additional support for usefulness of these 15 CDS symptoms as measured by the ACI to study CDS across various cultures.
Total lesion glycolysis by 18F‐fluorodeoxyglucose positron emission tomography predicts tumor aggressiveness in patients with extrahepatic bile duct carcinoma
Authors: Fukushima Ryosuke , Harimoto Norifumi , Kawai Shunsuke , Ishii Norihiro , Tsukagoshi Mariko , Igarashi Takamichi , Araki Kenichiro , Tomonaga Hiroyasu , Higuchi Tetsuya , Shirabe Ken 
Published: March 2024

AbstractBackground18F‐fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG‐PET/CT) parameters are prognostic factors in multiple malignancies. However, the prognostic value in bile duct carcinoma is unclear. We evaluated the impact of metabolic parameters of 18F‐FDG‐PET/CT in resectable extrahepatic bile duct carcinoma.MethodsWe retrospectively reviewed the records of 100 patients with extrahepatic bile duct carcinoma who had undergone 18F‐FDG‐PET/CT and subsequent surgical resection between January 2017 and January 2023. We calculated maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and investigated their prognostic significance.ResultsThe optimal cutoff values of SUVmax, MTV, and TLG for predicting overall survival (OS) after surgery were 3.88, 3.55 and 7.55, respectively. In multivariate analysis, each metabolic parameter influenced both OS and recurrence‐free survival (RFS). TLG showed the lowest Akaike information criteria statistic value, indicating that it had the best ability to predict OS and RFS. High TLG was significantly associated with the number of lymph node metastases and poorly differentiated type. Patients with high TLG showed poorer RFS and OS, which were significantly worse than in those with low TLG.ConclusionsTumor TLG predicted tumor malignancy potential and could be a useful prognostic predictor for extrahepatic bile duct carcinoma.
Predictive role of the prognostic nutritional index in patients with pancreatic ductal adenocarcinoma who underwent neoadjuvant chemoradiotherapy followed by curative pancreatic resection: A retrospective study using prospectively collected data
Authors: Suto Hironobu , Matsukawa Hiroyuki , Ando Yasuhisa , Oshima Minoru , Fuke Takuro , Nagao Mina , Yamana Hiroki , Kamada Hideki , Kumamoto Kensuke , Okano Keiichi 
Published: March 2024

AbstractBackgroundDespite a strong association between nutritional indices and disease prognosis, evidence regarding the evaluation of nutritional indices after preoperative treatment for pancreatic ductal adenocarcinoma (PDAC) is insufficient. We evaluated the clinical significance of the prognostic nutritional index (PNI) in patients with resectable (R‐) and borderline resectable (BR‐) PDAC who received neoadjuvant chemoradiotherapy (NACRT) followed by pancreatic resection.MethodsWe assessed 153 patients with R‐ and BR‐PDAC who underwent NACRT followed by curative resection between 2009 and 2022. We evaluated the association between preoperative PNI after NACRT and short‐ and long‐term outcomes.ResultsThe median preoperative PNI value after NACRT was 42.1, and the optimal cutoff value from the time‐dependent receiver operating characteristic curve was 38.6. The low PNI group (PNI < 38.6, n = 44) exhibited significantly worse inflammatory parameters, surgical outcomes, and prognoses than the high PNI group (PNI ≥ 38.6, n = 109). Multivariate analysis identified preoperative PNI ≤ 38.6 (hazard ratio [HR]: 2.32, 95% confidence interval [CI]: 1.00–5.38, p = .049), blood loss ≥1642 mL (HR: 3.05, 95% CI: 1.65–5.64, p < .001), node positive pathology (HR: 2.10, 95% CI: 1.32–3.34, p = .002), and lack of postoperative adjuvant chemotherapy (HR: 3.55, 95% CI: 2.05–6.15, p < .001) as significant predictors of overall survival.ConclusionsFor patients with R‐ and BR‐PDAC receiving preoperative treatment, it is imperative to closely monitor their nutritional status when determining the optimal surgical procedure timing.
Flush toilet use and its impact on health and non‐health expenditures
Authors: Li Junpeng , Vatsa Puneet , Ma Wanglin 
Published: March 2024

AbstractThis study analysed the effects of flush toilet use on health and non‐health expenditures incurred by rural Chinese. The instrumental‐variable‐based Tobit and endogenous treatment regression models were used to analyse the 2016 China Labour Force Dynamics Survey data while addressing the selection bias inherent in flush toilet use. The results showed that by improving rural residents' physical and mental health, flush toilet use reduced per capita health expenditure while increasing non‐health expenditure. Furthermore, using flush toilets had positive spillover effects, reducing the health expenditures of even those who did not use them. Factors affecting flush toilet use were also analysed.