bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paysage et création plastique : genèse du Châle espagnol, œuvre de Jean-Michel Fauquet
Authors: Crasson Aurèle 
Published: April 2024

Cet article rend compte de l’approche de la notion de paysage chez le photographe plasticien Jean-Michel Fauquet. Il évoque la façon dont, à l’aide d’une caméra, a été traitée la genèse d’une photographie titrée « Le Châle espagnol », photographie d’une montagne qui, après avoir subi de multiples dégradations au tirage, révèle un chien colossal monté par un cavalier. L’approche génétique visait un double effet, faire remonter les traces matérielles permettant de reconstituer la création de l’œuvre et montrer la relation que l’artiste entretien avec le paysage et ce qu’il met en œuvre pour en donner une représentation. Cet article cherche à soulever la question de la complexité de la représentation du paysage, et à montrer comment chez Jean-Michel Fauquet le paysage résulte d’une construction mémorielle, d’une «antériorité».
A circulação dos processos de criação na literatura, nas artes e nas ciências (texto móvel, condições iniciais e atrator no manuscrito)
Authors: Willemart Philippe 
Published: April 2024

O manuscrito proustiano senão todos os manuscritos, exibe uma sensibilidade recorrente às condições iniciais sob a influência simultânea do « texto móvel » que age a cada rasura e de um atrator específico. Após ter lembrado o conceito de « texto móvel », interrogarei o caminho que leva à escritura ou as condições iniciais em Flaubert, Freud, Proust e o neurocientista Edelman para chegar ao contrapeso destas condições iniciais, o atrator estranho (Ruelle) que dará a dimensão fractal à narrativa. Analisarei em seguida o percurso do atrator principal de Na busca do tempo perdido que latente no início, se fará explícito desde 1913 sobre os manuscritos Bodmer e atrairá a personagem Albertine para se concentrar depois sobre o herói quando constatará que todos os materiais da obra literária […] estavam nele: era minha vida passada. O atrator estranho tinha reunido os dois tempos: o tempo redescoberto e o tempo perdido.
Edição Genética de uma Tradução Imperial: o livro do Hitopadeça por D. Pedro II
Authors: Mafra Adriano 
Published: April 2024

Este artigo visa a demonstrar o processo que culminou na edição genética dos manuscritos tradutórios do monarca D. Pedro II da coletânea em sânscrito denominada Hitopadeça. Da tradução do texto em sânscrito, o montante chega a 88 páginas manuscritas que passaram a compor 45 fólios editados. O método empregado para a edição do material selecionado foi a transcrição diplomática e a proposta se enquadra naquilo que Biasi (2010) considera uma edição horizontal, já que as muitas campanhas de escritura dividem o espaço de uma única versão em manuscrito. O estudo apresenta ainda algumas considerações acerca do estudo microgenético dos manuscritos do Hitopadeça, cujos movimentos de escritura, evidenciados, possibilitaram definir o perfil de tradutor e o papel da tradução na vida do monarca.
An End-to-End Musical Instrument System That Translates
Electromyogram Biosignals to Synthesized Sound
Authors: Tanaka Atau , Visi Federico , Donato Balandino Di , Klang Martin , Zbyszyński Michael 
Published: April 2024

Abstract
This article presents a custom system combining hardware and software that senses physiological signals of the performer's body resulting from muscle contraction and translates them to computer-synthesized sound. Our goal was to build upon the history of research in the field to develop a complete, integrated system that could be used by nonspecialist musicians. We describe the Embodied AudioVisual Interaction Electromyogram, an end-to-end system spanning wearable sensing on the musician's body, custom microcontroller-based biosignal acquisition hardware, machine learning–based gesture-to-sound mapping middleware, and software-based granular synthesis sound output. A novel hardware design digitizes the electromyogram signals from the muscle with minimal analog preprocessing and treats it in an audio signal-processing chain as a class-compliant audio and wireless MIDI interface. The mapping layer implements an interactive machine learning workflow in a reinforcement learning configuration and can map gesture features to auditory metadata in a multidimensional information space. The system adapts existing machine learning and synthesis modules to work with the hardware, resulting in an integrated, end-to-end system. We explore its potential as a digital musical instrument through a series of public presentations and concert performances by a range of musical practitioners.
Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
Authors: Streeter Sarah A. , Williams Alexandria G. , Evans James R. , Wang Jing , Guarnaccia Alissa D. , Florian Andrea C. , Al-Tobasei Rafet , Liu Qi , Tansey William P. , Weissmiller April M. 
Published: April 2024

Abstract
Background
During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impaired, leading to genomic instability and tumor evolution. Recently it was discovered that the chromatin regulator WDR5—a critical MYC cofactor—regulates expression of genes needed in mitosis through a direct interaction with the master kinase PDPK1. However, whether PDPK1 and WDR5 contribute to similar mitotic gene regulation in MYC-overexpressing cancers remains unclear. Therefore, to characterize the influence of WDR5 and PDPK1 on mitotic gene expression in cells with high MYC levels, we performed a comparative transcriptomic analysis in neuroblastoma cell lines defined by MYCN-amplification, which results in high cellular levels of the N-MYC protein.

Results
Using RNA-seq analysis, we identify the genes regulated by N-MYC and PDPK1 in multiple engineered CHP-134 neuroblastoma cell lines and compare them to previously published gene expression data collected in CHP-134 cells following inhibition of WDR5. We find that as expected N-MYC regulates a multitude of genes, including those related to mitosis, but that PDPK1 regulates specific sets of genes involved in development, signaling, and mitosis. Analysis of N-MYC- and PDPK1-regulated genes reveals a small group of commonly controlled genes associated with spindle pole formation and chromosome segregation, which overlap with genes that are also regulated by WDR5. We also find that N-MYC physically interacts with PDPK1 through the WDR5-PDPK1 interaction suggesting regulation of mitotic gene expression may be achieved through a N-MYC-WDR5-PDPK1 nexus.

Conclusions
Overall, we identify a small group of genes highly enriched within functional gene categories related to mitotic processes that are commonly regulated by N-MYC, WDR5, and PDPK1 and suggest that a tripartite interaction between the three regulators may be responsible for setting the level of mitotic gene regulation in N-MYC amplified cell lines. This study provides a foundation for future studies to determine the exact mechanism by which N-MYC, WDR5, and PDPK1 converge on cell cycle related processes.
A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study
Authors: Domínguez-Ruiz María , Murillo-Cuesta Silvia , Contreras Julio , Cantero Marta , Garrido Gema , Martín-Bernardo Belén , Gómez-Rosas Elena , Fernández Almudena , del Castillo Francisco J. , Montoliu Lluís , Varela-Nieto Isabel , del Castillo Ignacio 
Published: April 2024

AbstractInherited hearing impairment is a remarkably heterogeneous monogenic condition, involving hundreds of genes, most of them with very small (< 1%) epidemiological contributions. The exception is GJB2, the gene encoding connexin-26 and underlying DFNB1, which is the most frequent type of autosomal recessive non-syndromic hearing impairment (ARNSHI) in most populations (up to 40% of ARNSHI cases). DFNB1 is caused by different types of pathogenic variants in GJB2, but also by large deletions that keep the gene intact but remove an upstream regulatory element that is essential for its expression. Such large deletions, found in most populations, behave as complete loss-of-function variants, usually associated with a profound hearing impairment. By using CRISPR-Cas9 genetic edition, we have generated a murine model (Dfnb1em274) that reproduces the most frequent of those deletions, del(GJB6-D13S1830). Dfnb1em274 homozygous mice are viable, bypassing the embryonic lethality of the Gjb2 knockout, and present a phenotype of profound hearing loss (> 90 dB SPL) that correlates with specific structural abnormalities in the cochlea. We show that Gjb2 expression is nearly abolished and its protein product, Cx26, is nearly absent all throughout the cochlea, unlike previous conditional knockouts in which Gjb2 ablation was not obtained in all cell types. The Dfnb1em274 model recapitulates the clinical presentation of patients harbouring the del(GJB6-D13S1830) variant and thus it is a valuable tool to study the pathological mechanisms of DFNB1 and to assay therapies for this most frequent type of human ARNSHI.
Integrated metabolomic and transcriptomic analyses provide insights into regulation mechanisms during bulbous stem development in the Chinese medicinal herb plant, Stephania kwangsiensis
Authors: Huang Hao , Wei Ying , Huang Shaojun , Lu Shijian , Su Huasheng , Ma Liuhui , Huang Weiping 
Published: April 2024

Abstract
Background
Stephania kwangsiensis Lo (Menispermaceae) is a well-known Chinese herbal medicine, and its bulbous stems are used medicinally. The storage stem of S. kwangsiensis originated from the hypocotyls. To date, there are no reports on the growth and development of S. kwangsiensis storage stems.

Results
The bulbous stem of S. kwangsiensis, the starch diameter was larger at the stable expanding stage (S3T) than at the unexpanded stage (S1T) or the rapidly expanding stage (S2T) at the three different time points. We used ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and Illumina sequencing to identify key genes involved in bulbous stem development. A large number of differentially accumulated metabolites (DAMs) and differentially expressed genes (DEGs) were identified. Based on the differential expression profiles of the metabolites, alkaloids, lipids, and phenolic acids were the top three differentially expressed classes. Compared with S2T, significant changes in plant signal transduction and isoquinoline alkaloid biosynthesis pathways occurred at both the transcriptional and metabolic levels in S1T. In S2T compared with S3T, several metabolites involved in tyrosine metabolism were decreased. Temporal analysis of S1T to S3T indicated the downregulation of phenylpropanoid biosynthesis, including lignin biosynthesis. The annotation of key pathways showed an up-down trend for genes and metabolites involved in isoquinoline alkaloid biosynthesis, whereas phenylpropanoid biosynthesis was not completely consistent.

Conclusions
Downregulation of the phenylpropanoid biosynthesis pathway may be the result of carbon flow into alkaloid synthesis and storage of lipids and starch during the development of S. kwangsiensis bulbous stems. A decrease in the number of metabolites involved in tyrosine metabolism may also lead to a decrease in the upstream substrates of phenylpropane biosynthesis. Downregulation of lignin synthesis during phenylpropanoid biosynthesis may loosen restrictions on bulbous stem expansion. This study provides the first comprehensive analysis of the metabolome and transcriptome profiles of S. kwangsiensis bulbous stems. These data provide guidance for the cultivation, breeding, and harvesting of S. kwangsiensis.
The influence of climate change on the future distribution of two Thymus species in Iran: MaxEnt model-based prediction
Authors: Hosseini Naser , Ghorbanpour Mansour , Mostafavi Hossein 
Published: April 2024

AbstractWithin a few decades, the species habitat was reshaped at an alarming rate followed by climate change, leading to mass extinction, especially for sensitive species. Species distribution models (SDMs), which estimate both present and future species distribution, have been extensively developed to investigate the impacts of climate change on species distribution and assess habitat suitability. In the West Asia essential oils of T. daenensis and T. kotschyanus include high amounts of thymol and carvacrol and are commonly used as herbal tea, spice, flavoring agents and medicinal plants. Therefore, this study aimed to model these Thymus species in Iran using the MaxEnt model under two representative concentration pathways (RCP 4.5 and RCP 8.5) for the years 2050 and 2070. The findings revealed that the mean temperature of the warmest quarter (bio10) was the most significant variable affecting the distribution of T. daenensis. In the case of T. kotschyanus, slope percentage was the primary influencing factor. The MaxEnt modeling also demonstrated excellent performance, as indicated by all the Area Under the Curve (AUC) values exceeding 0.9. Moreover, based on the projections, the two mentioned species are expected to undergo negative area changes in the coming years. These results can serve as a valuable achievement for developing adaptive management strategies aimed at enhancing protection and sustainable utilization in the context of global climate change.
Pre-COVID-19-pandemic RSV epidemiology and clinical burden in pediatric primary care in Italy: a comparative analysis across two regions for the 2019/2020 season
Authors: Pandolfi Elisabetta , Loconsole Daniela , Chironna Maria , van Summeren Jojanneke , Paget John , Raponi Massimiliano , Russo Luisa , Campagna Ilaria , Croci Ileana , Concato Carlo , Perno Carlo Federico , Tozzi Alberto Eugenio , Linardos Giulia , Bartolucci Veronica , Ciampini Sara , Muda Andrea Onetti , De Angelis Luigi , Ciofi Degli Atti Marta Luisa , Rizzo Caterina 
Published: April 2024

Abstract
Background
Respiratory syncytial virus (RSV) infection in children under 5 years have a significant clinical burden, also in primary care settings. This study investigates the epidemiology and burden of RSV in Italian children during the 2019/20 pre-pandemic winter season.

Methods
A prospective cohort study was conducted in two Italian regions. Children with Acute Respiratory Infection (ARI) visiting pediatricians were eligible. Nasopharyngeal swabs were collected and analyzed via multiplex PCR for RSV detection. A follow-up questionnaire after 14 days assessed disease burden, encompassing healthcare utilization and illness duration. Statistical analyses, including regression models, explored associations between variables such as RSV subtype and regional variations.

Results
Of 293 children with ARI, 41% (119) tested positive for RSV. Median illness duration for RSV-positive cases was 7 days; 6% required hospitalization (median stay: 7 days). Medication was prescribed to 95% (110/116) of RSV cases, with 31% (34/116) receiving antibiotics. RSV subtype B and regional factors predicted increased healthcare utilization. Children with shortness of breath experienced a 36% longer illness duration.

Conclusions
This study highlights a significant clinical burden and healthcare utilization associated with RSV in pre-pandemic Italian primary care settings. Identified predictors, including RSV subtype and symptomatology, indicate the need for targeted interventions and resource allocation strategies. RSV epidemiology can guide public health strategies for the implementation of preventive measures.
Epidemiological investigation of dengue fever outbreak and its socioeconomic determinants in Banadir region, Somalia
Authors: Mohamed Mohamed Abdelrahman , Hassan Nuralein Yusuf , Osman Marian Muse , Gedi Saido , Maalin Bisma Abdullahi Ali , Sultan Kasim Mahdi , Garba Bashiru , Osman Ali Abdirahman , Osman Abdinasir Yusuf , Ahmed Abdifatah Diriye 
Published: April 2024

Abstract
Background
Dengue has become an alarming global problem and is endemic in many countries, particularly in tropical and subtropical countries. The aim of this study was to investigate dengue fever outbreak in Banadir Region, Somalia, to understand the risk factors (time, place, personal characteristics).

Methods
A descriptive cross-sectional study was undertaken to determine the levels of circulating anti-dengue virus antibodies and DENV NS1 antigen among Banadir Region residents, while a questionnaire survey was conducted to understand the clinical and demographic characteristics of the patients.

Results
A total of 735 febrile patients were studied, with 55.6% men and 44.3% women. The majority of the participants were children aged 14 years and younger. Among them, 10.8% tested positive for IgM antibodies against dengue virus (DENV), while the prevalence of DENV NS1 antigen was 11.8%. Fever and myalgia were the most common symptoms observed in the DENV-positive patients.

Conclusions
A dengue fever outbreak has been confirmed in Banadir region, Somalia. This study provides information on the most affected districts and identifies risk factors contributing to DF outbreaks. The study recommends improving outbreak readiness and response, particularly in surveillance and laboratory diagnostics, by fostering intersectoral collaboration and establishing regulatory frameworks for financial and operational participation.
Low-dose aspirin for the prevention of preterm birth in nulliparous women: systematic review and meta-analysis
Authors: Yan Xin , Zheng Wei , Wang Jia , Yuan Xianxian , Li Guanghui 
Published: April 2024

Abstract
Objective
The objective was to assess the efficacy and safety of low-dose aspirin for the prevention of preterm birth in nulliparous women.

Data sources
We searched PubMed, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to June 2022.

Study eligibility criteria
Randomized controlled trials that compared aspirin to placebo in nulliparous women were eligible.

Methods
This study was reported in accordance with the PRISMA 2020 checklist. The primary outcomes of this study were the rates of preterm birth at less than 37 weeks and less than 34 weeks of gestation. The secondary outcomes included postpartum hemorrhage, placental abruption, cesarean section, any hypertensive disorder of pregnancy and small for gestational age. Relative risks with their 95% confidence intervals were calculated for analysis. Heterogeneity was assessed by Cochran’s Q test and Higgins’s I2. A random-effects model was used when I2 was > 50% to generate the RR and 95% CI; otherwise, a fixed-effects model was used. The risk of publication bias was assessed by funnel plots. We performed sensitivity analysis by sequentially omitting each included study to confirm the robustness of the analysis.

Results
Seven studies with a total of 29,029 participants were included in this review. Six studies were assessed as having a low risk of bias or an unclear risk of bias, and one study was judged as having a high risk of bias. In nulliparous women, low-dose aspirin was associated with a significant reduction in the rate of preterm birth at less than 34 weeks of gestational age (RR 0.84,95% CI: 0.71–0.99; I2 = 0%; P = 0.04), but we did not observe a significant difference in the rate of preterm birth at less than 37 weeks of gestation (RR 0.96,95% CI: 0.90–1.02; I2 = 31%; P = 0.18). Low-dose aspirin was associated with a significant increase in the rates of postpartum hemorrhage (RR 1.32,95% CI: 1.14–1.54; I2 = 0%; P = 0.0003), placental abruption (RR 2.18,95% CI: 1.10–4.32; I2 = 16%; P = 0.02) and cesarean section (RR 1.053, 95% CI: 1.001–1.108; I2 = 0%; P = 0.05) in nulliparous women. We also did not observe a significant effect of low-dose aspirin on the rates of any hypertensive disorder of pregnancy (RR 1.05, 95% CI: 0.96–1.14; I2 = 9%; P = 0.28) or small for gestational age (RR 0.96, 95% CI: 0.91–1.02; I2 = 0%; P = 0.16) in nulliparous women. Funnel plots indicated that no significant publication bias existed in this meta-analysis. Except for preterm birth at less than 34 weeks of gestation, placental abruption and cesarean section, the sensitivity analysis showed similar results, which confirmed the robustness of this meta-analysis.

Conclusions
Low-dose aspirin might reduce the risk of preterm birth at less than 34 weeks of gestation in nulliparous women. The use of low-dose aspirin in nulliparous women increased the risk of postpartum hemorrhage and might increase the risk of placental abruption and cesarean section.
Pregnant and postpartum women’s experiences of the indirect impacts of the COVID-19 pandemic in high-income countries: a qualitative evidence synthesis
Authors: Tan Annie , Blair Amanda , Homer Caroline SE. , Digby Robin , Vogel Joshua P. , Bucknall Tracey 
Published: April 2024

Abstract
Background
Pregnant and postpartum women’s experiences of the COVID-19 pandemic, as well as the emotional and psychosocial impact of COVID-19 on perinatal health, has been well-documented across high-income countries. Increased anxiety and fear, isolation, as well as a disrupted pregnancy and postnatal period are widely described in many studies. The aim of this study was to explore, describe and synthesise studies that addressed the experiences of pregnant and postpartum women in high-income countries during the first two years of the pandemic.

Methods
A qualitative evidence synthesis of studies relating to women’s experiences in high-income countries during the pandemic were included. Two reviewers extracted the data using a thematic synthesis approach and NVivo 20 software. The GRADE-CERQual (Confidence in the Evidence from Reviews of Qualitative research) was used to assess confidence in review findings.

Results
Sixty-eight studies were eligible and subjected to a sampling framework to ensure data richness. In total, 36 sampled studies contributed to the development of themes, sub-themes and review findings. There were six over-arching themes: (1) dealing with public health restrictions; (2) navigating changing health policies; (3) adapting to alternative ways of receiving social support; (4) dealing with impacts on their own mental health; (5) managing the new and changing information; and (6) being resilient and optimistic. Seventeen review findings were developed under these themes with high to moderate confidence according to the GRADE-CERQual assessment.

Conclusions
The findings from this synthesis offer different strategies for practice and policy makers to better support women, babies and their families in future emergency responses. These strategies include optimising care delivery, enhancing communication, and supporting social and mental wellbeing.