bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homœopathic treatment of acute childhood diarrhoea
Authors: Jiminez Luz Margarita , Gloyd Steven , Carares Felix Esponiza , Gaitan Margarita Paniagua , Crothers Dean , Jacobs Jennifer 
Published: September 2006

AbstractA double-blind, randomized clinical trial to compare homœopathic treatment versus placebo in the treatment of acute childhood diarrhoea was carried out in Leon, Nicaragua, in July 1990. 34 children aged 6 months to 5 years were randomized into active and placebo groups, both of which also received oral rehydration treatment. The mean duration of diarrhoea after treatment in the active group was 2.4 days, compared to 3.0 days in the placebo group, which was not statistically significant. Exploratory analysis revealed a statistically significant decrease (p=0.04) in the subgroup of patients for which an aetiological agent was found. There was also a significant difference in number of stools per day in the treated group (p=0.002) at the end of the treatment period. Since small numbers prevent a definitive conclusion from this study, further study with a larger sample size would seem appropriate.
The experimental wave analysis of the heart potentials
Authors: Boyd W.E. 
Published: September 2006

Synopsis
Previous research demonstrated the presence of a range of varying low frequency potentials on the surface of the human body covering a range of 10 to 2000 c/s. It was shown that a large part of these varying potentials originated from the activating wave of potential. Normally this wave of potential is recorded as an electrocardiogram. The QRS part of the electrocardiogram may be triangular, diphasic, M shape, etc., and has for many years been chiefly recorded by the Einthoven String Oscillograph of comparatively high inertia. Of recent years attention has been drawn to improved recording by C.R.O. or moving coil oscillograph. The usual custom with C.R.O. recording is to suppress higher frequencies in order to produce a smoother recording. This research demonstrated that the QRS wave contains a large range of higher frequencies of a variable nature which cannot be normally observed in detail in the ordinary recording, but which can be selected and observed by methods of electronic wave analysis. It is shown that undistorted recording necessitates careful attention to technical details and requires special amplifier circuits of which one developed for this research is given. Examples of clinical recordings are given, including the oscilloscope recording of the frog's heart with the changes in the anlaysis form during the action of a drug.The application of a mechanical photo-electric source for an artificial patient as suggested by Robertson is made use of and elaborated, while the value of this method for other electronic tests is shown.
The need for a scientific attitude
Authors: Sankaran P. 
Published: September 2006

SummaryThe greatness of Hahnemann, the founder of Homœopathy, and the essential truth of the principles propounded by him are emphasized. But it is proposed that his discoveries should serve more as a starting point than as the end. The plea for a scientific outlook is put forth whereby the discoveries of Hahnemann may be re-examined, re-interpreted and if necessary re-adjusted in the light of newer knowledge and newer circumstances, to make Homœopathy more certain, speedy, effective and acceptable.
Observations on the effect of steroidal urinary extract on sub-acute and chronic rheumatoid arthritis
Authors: Boman-Behram A.K. 
Published: September 2006

SummarySeventeen patients suffering from subacute and chronic rheumatoid arthritis, 20 to 69 years old, and with duration varying from 6 months to 20 years, were treated with steroidal extracts from their own urine. All of them had a preliminary aggravation soon after taking the extract. Fifteen patients responded favourably as judged by their general condition, and improvement in swelling and mobility of the affected joints.
Phosphorus in acute diseases of infancy and childhood
Authors: Foubister D.M. 
Published: September 2006

SummaryFour characteristics of Phosphorus are described—the appearance, alertness, reaction to affection and anxiety which can easily be observed in children. The main differences between Phos., Calc. phos. and Ferrum phos. are discussed, and a few other remedies occasionally resembling, Phos. are mentioned.
Magnesia muriatica
Authors: Fergus Stewart T. 
Published: September 2006

SummaryThis paper has attempted to illustrate that Magnesia muriatica is an interesting and useful remedy which has perhaps been neglected.The indications for its prescription in a number of patients have been discussed, and it has been suggested that it is useful in patients who are depressed, and suffer from nasal and liver troubles.There are a number of peculiar little symptoms which might indicate that it should be prescribed when one would tend to give Lycopodium, Merc., Natrum mur., Natrum sulph., or Pulsatilla, either as a constitutional remedy or on account of the presenting symptoms.In conclusion I have composed a little rhyme, I could hardly call it a poem, but it does at least remind us of some of the salient symptoms of this remedy, so I trust those of you who are real poets will forgive me for my levity!
Acute respiratory disease in childhood
Authors: Boyd H.W. 
Published: September 2006

SummaryA series of 63 cases of bronchopneumonia and acute bronchitis in children is described, in which 22 cases of bronchopneumonia and 29 cases of acute bronchitis were treated with homœopathic remedies alone. The results are discussed and the suggestion made that large scale research is required to study the activity of these preparations.
A proving of Aqua marina
Authors: Sankaran P. 
Published: September 2006

SummaryAn attempt was made at proving Aqua marina and the results are published. It would be better to call this an attempt at a proving, for in several ways this proving falls short of optimum requirements. For example, we did not do pathological, bacteriological and radiological examinations, as is being done in modern provings. However, we are publishing this proving in the hope that it will stimulate further provings of this substance by other homœopaths, so that we shall be able to gather rich material concerning this substance.I am deeply indebted to my students and house physicians for their assistance in carrying out this proving, and to my friend Dr. M. O. Shaikh for assisting me in collating the results. I must also express my gratitude to Messrs. Nelson of London for supplying the necessary medicines.
Quadruple nosode
Authors: Kerr John Fraser 
Published: September 2006

SummaryIt appears that the Quadruple Nosode was effective in keeping about 84% of patients free from incapacitating respiratory infections in winter, even in a city community in the Midlands. Of the 16% of patients who got infections in spite of the nosode, it is clear that many of them had milder infections than expected. Four of them had the misfortune to take a dose during the incubation of a cold and suffered aggravations, but they may have developed an even better immunity as a compensation. Persons with deep-seated chronic illnesses may react badly and need treating with extra care. It seems clear that Quadruple Nosode is a powerful prophylactic agent against respiratory infections which can be given to healthy persons with a high degree of success.
Coronary artery disease
Authors: Stewart T.F. 
Published: September 2006

SummaryThis paper has discussed the diagnosis, age incidence, medicinal treatment and mortality of coronary artery disease. From the case records of forty patients admitted to the Glasgow Homœopathic Hospital with coronary disease it has extracted the individual symptoms on which homœopathic medicines were prescribed for individual patients. The main part of the discussion is on the homœopathic remedies used, the remedies are discussed in the order of frequency of use, but the incidents reported are selected for their individual interest.
Minicomputers in Homœopathy
Authors: De Ruyter E.A.A.A.D. 
Published: September 2006

SummaryRepertory analysis of homœopathic cases has always been very time-consuming. For this reason homœopathic doctors have often had to restrict themselves to searching for the most likely remedies from a total of frequently as few as 50 most common remedies. The use of a relatively inexpensive minicomputer for repertory selection from a total of 352 homœopathic remedies based on the 501 most common symptoms from Boericke's Repertory is described. This procedure greatly reduces the time needed for and improves the accuracy of repertory analysis.
Facial neuralgia
Authors: Hoa Jacques Hui Bon 
Published: September 2006

SummaryWhen confronted with a case of facial neuralgia, and if this is seated on the right and there is an absence of other indications, there is a strong chance that the remedy will be Kalmia latifolia. If it is seated on the left and the eyeball is affected, the remedy is Spigelia. If the pain is of the electrical discharge type and seated at the level of the left upper lip, or else of the lower left gum, the remedy is Colocynthis. When the pain appears gradually and disappears slowly, whether seated on the right or on the left, the remedy is Stannum. If the pain is aggravated by draughts, think of Nux vomica. If it is aggravated by the cold, think of Silicea. Sulphur and Calcarea carbonica are the two remedies for facial neuralgia which are at the same time the constitutional remedy for the patient, an exception to the rule which says that facial neuralgia is never treated constitutionally.Facial pain of vascular ogirin, on the other hand, is treated constitutionally, like migraine (Sepia, Aurum, Pulsatilla).
Parallel effects of Pulsatilla and exogenous leutocyclin on the rat ovary, uterus and thyroid
Authors: Prasad Suresh , Chandrasekhar K. 
Published: September 2006

SummaryA comparative study of Pulsatilla (a homœopathic medicine) and leutocyclin was undertaken in female albino rats showing regular oestrus cycles. Pulsatilla in the 30th and 200th potencies was administered orally, and leutocyclin was injected in doses of 0·125 mg and 1·25 mg. 0·25 ml/dose of 90 per cent. alcohol was used as the vehicle.Pulsatilla 30 and 200 and leutocyclin at a dose of 1·25 mg markedly reduced the weight of the ovary. The higher dose of leutocyclin (1·25 mg) and both the attenuations of Pulsatilla increased the process of atresia in ovarian follicles. But a simultaneous decrease in the number and diameters of the corpora lutea was observed.Administration of Pulsatilla and leutocyclin resulted in reduction in the weight of the uterus and the height of the endometrium and luminal epithelium. There was also a reduction in the height of epithelial cells in the thyroid. Both Pulsatilla and leutocyclin enhanced mitotic division in the uterine stroma.The results indicate that leutocyclin in doses of between 0·125 mg and 1·25 mg may be used to produce similar changes in the ovary, uterus and thyroid of the rat as Pulsatilla 30 and 200.
The place for non-pharmaceutical therapy in chronic rheumatoid arthritis: A critical study of homœopathy
Authors: Gibson Robin G. , Gibson Sheila L.M. , Macneill Alistair D. , Buchanan W. Watson 
Published: September 2006

SummaryA two-part trial is reported in which patients with rheumatoid arthritis were treated with homœopathy. In the first part of the trial, 54 patients on homœopathy were compared with 41 patients on salicylate over the course of a year. 66 per cent. of the patients on homœopathy improved, as compared with 14.6 per cent. of the patients on salicylate.In the second part of the trial, 46 patients took part in a double-blind study in which homœopathy was compared with placebo for a period of three months. The patients on homœopathy improved significantly while those on placebo did not.It was also shown that it may well be possible to predict which patients are most likely to respond to homœopathic treatment.No toxic effects were observed in any patient on homœopathy whereas 39 per cent. of the patients on salicylate experienced toxic effects.
Observations on the effect of house dust potencies
Authors: Morris-Owen R.M. , Datt-Lai K. 
Published: September 2006

SummaryA short term study of the effect of House-dust potencies (30, 200) has been made in seventy-nine nasal or naso-bronchial patients with some degree of irritable reaction to inhaled house dust.Sixty-two firm assessments of the initial treatments were made: in twenty-three there was clearly no effect, twenty-eight showed remissions of varying tempo and duration: in seven of these there were associated ‘reactive’ features. Eleven showed only symptomatic effects which might be considered as “reactive” or as “proving” manifestations.Detail is given of the further course of those who began with remission, and of the symptoms encountered in the aggravations. Immunity to the effects of dust inhalation was an outstanding feature of the remissions, which however generally covered the whole symptomatic behaviour as well.Only six patients have so far appeared capable of long-term response to treatment with House dust potencies alone.The effects are compared with those of house dust injections, and it is clearly indicated that the two treatments operate on different lines.Tentative suggestions are made for the discrimination of patients who may respond to the potencies and for the bearing these observations have on the design of a controlled trial.
New toxicology: Carcinogenesis II
Authors: Fisher Peter 
Published: September 2006

SummaryThis is the second article of a series of three. After reviewing the history and main groups of chemical carcinogens described in the first article, we will go on to look at directly acting carcinogens and their mutagenic properties. The most important group of direct carcinogens are the mustard compounds and it is from these that the modern cytotoxic drugs evolved. We will consider the cytotoxic drugs in the light of homœopathy and conclude with a look at the phenomenon of cocarcinogenesis.
The action of “low potency” homœopathic remedies on the movement of guinea-pig macrophages and human leucocytes
Authors: Moss Victor A. , Alan Roberts J. , Simpson Keith 
Published: September 2006

SummaryThe action of five “low potency” homœopathic remedies, as supplied to the public and used clinically, on the distance of movement in a given time of guinea-pig macrophages and human leucocytes was measured. The remedies, Belladonna, Hepar sulphur, Pyrogenium, Silicea and Staphylococcin, were tested in the range 2×10−10 to 10−16 g/ml dilution of the source material, though the actual concentration of any active agent was probably considerably less than these values.In four series of experiments with guinea-pig macrophages the remedies were tested as aqueous or alcoholic tinctures, or absorbed on sugar granules. The results of 533 tests showed statistically significant modification of cell movement in 47 tests (i.e. 95% significant in about 8% of tests). Ten of these differences were significant at the 99% level and three also at the 99.9% level.Fifty tests of the aqueous tinctures on leucocytes from four human subjects showed modification of cell movement in five tests, one test being significant at the 99% level. Significant effects were obtained with two subjects only.The remedies facilitated movement in some experiments and inhibited it in others. The largest effects were obtained with a few sensitive guinea-pigs and one human subject. The magnitude and direction of the effects depended on the batch of animals being tested rather than on the set of remedies used.It is concluded that low potency homœopathic remedies prepared by A. Nelson & Company Ltd. are capable of modifying the movement of human leucocytes and guinea-pig macrophages in vitro.
Antiviral efficacy of homœopathic drugs against animal viruses
Authors: Singh L.M. , Gupta Girish 
Published: September 2006

SummaryThe antiviral effect of homœopathic drugs against two animal viruses, Chicken Embryo Virus (CEV) of fowls and Simliki Forest Virus (SFV), causing encephalitis and death in mice were investigated. In all 10 drugs in 33 potencies were tested against CEV and 8 drugs in 26 potencies showed varying degree of virus inhibition. The drugs that caused 100% inhibition of CEV were Typhoidinum 200, Hydrophobinum 1000, Tuberculinum 1000, Nux vomica 200, and Malandrinum 1000. Of the drugs tested in 11 potencies against SFV, none were found effective in either preventing disease or death of mice infected with this virus.
Report on the status of research on homœopathy with recommendations for future research
Authors: Rubik Beverley 
Published: September 2006

AbstractMedicine has its roots in the art of practice, but scientific validation is of increasing importance in the incorporation of new therapeutics. There have been a number of well-designed research studies on homœopathy, but much remains to be done toward understanding its modus operandi and its relationship to the healing process. An examination and understanding of homœopathy by contemporary science would undoubtedly lead to its wider acceptance and use. For a critical and comprehensive review of research on homœopathy, the reader is referred to Scofield's two-part reviews, 1,2 This report addresses results from the most experimentally promising and rigorous studies in the modern literature and addresses some areas of proposed investigation. It highlights important research areas that are cost-effective at three distinct levels from the fundamental to the applied: (1) the physics and chemistry of homœopathy preparations, (2) laboratory studies using homœpathic preparations on cells and organisms, and (3) clinical trials using homœopathic medicines.
Elevation of serum globulin levels in Chelidonium majus 6c provers
Authors: Vakil A.E. , Vakil Y.e. , Nanabhai A.S. 
Published: September 2006

AbstractTen healthy volunteers were administered orally 0.04 ml. of Chelidonium majus 6c t.d.s. for 21 days. Seven healthy volunteers were kept as controls and administered orally 0.04 ml. of 90% ethanol t.d.s. The trial was single blind. Fasting venous samples were collected before and after the trial. Serum samples were analysed for total bilirubin, albumin, globulin, total cholesterol, prothrombin time and GPT. Serum globulins registered an increase of 58%, while the other parameters showed no changes.
SEBINI: Software Environment for BIological Network Inference
Authors: Taylor Ronald C. , Shah Anuj , Treatman Charles , Blevins Meridith 
Published: September 2006

Abstract
Summary: The Software Environment for BIological Network Inference (SEBINI) has been created to provide an interactive environment for the deployment and evaluation of algorithms used to reconstruct the structure of biological regulatory and interaction networks. SEBINI can be used to compare and train network inference methods on artificial networks and simulated gene expression perturbation data. It also allows the analysis within the same framework of experimental high-throughput expression data using the suite of (trained) inference methods; hence SEBINI should be useful to software developers wishing to evaluate, compare, refine or combine inference techniques, and to bioinformaticians analyzing experimental data. SEBINI provides a platform that aids in more accurate reconstruction of biological networks, with less effort, in less time.
Availability: A demonstration website is located at . The Java source code and PostgreSQL database schema are available freely for non-commercial use.
Contact: ronald.taylor@pnl.gov
Dynamic partitioning for hybrid simulation of the bistable HIV-1 transactivation network
Authors: Griffith Mark , Courtney Tod , Peccoud Jean , Sanders William H. 
Published: September 2006

Abstract
Motivation: The stochastic kinetics of a well-mixed chemical system, governed by the chemical Master equation, can be simulated using the exact methods of Gillespie. However, these methods do not scale well as systems become more complex and larger models are built to include reactions with widely varying rates, since the computational burden of simulation increases with the number of reaction events. Continuous models may provide an approximate solution and are computationally less costly, but they fail to capture the stochastic behavior of small populations of macromolecules.
Results: In this article we present a hybrid simulation algorithm that dynamically partitions the system into subsets of continuous and discrete reactions, approximates the continuous reactions deterministically as a system of ordinary differential equations (ODE) and uses a Monte Carlo method for generating discrete reaction events according to a time-dependent propensity. Our approach to partitioning is improved such that we dynamically partition the system of reactions, based on a threshold relative to the distribution of propensities in the discrete subset. We have implemented the hybrid algorithm in an extensible framework, utilizing two rigorous ODE solvers to approximate the continuous reactions, and use an example model to illustrate the accuracy and potential speedup of the algorithm when compared with exact stochastic simulation.
Availability: Software and benchmark models used for this publication can be made available upon request from the authors.
Contact: tod@crhc.uiuc.edu
Supplementary information: Complete lists of reactions and parameters of the HIV-1 Tat transactivation model, as well as additional results for other benchmark models, are available at
Health preferences and decision‐making needs of disadvantaged women
Authors: Bunn Helen , Lange Ilta , Urrutia Mila , Sylvia Campos Maria , Campos Solange , Jaimovich Sonia , Campos Cecilia , Jacobsen Mary Jane , Gaboury Isabelle 
Published: September 2006

Aim.  This paper reports the results of a survey of disadvantaged women in La Pintana, a municipality of Santiago, Chile, to determine their health decision‐making needs.Background.  Research is needed as there is no published community‐based study focusing specifically on health decision‐making needs of disadvantaged women.Methods.  From April to November 1999, we conducted a cross‐sectional interview survey of women registered at primary healthcare centres in La Pintana, an impoverished municipality of Santiago, Chile.Results.  The survey participants were 554 adult women over 15 years of age. Seventy‐five percent reported making current health‐related decisions. Types of decisions were primarily about navigation: where, when and from whom to seek care. The most common role in decision‐making was sharing the decision with others, specifically husbands and other family members. Fifty‐four percent experienced decisional conflict or uncertainty about options. Those reporting more manifestations of decisional conflict were more likely to lack information on available options, pros and cons of the options, and chances of benefits and harms associated with the options; they were also more likely to be unclear about what was important to them, to feel pressure from others, lack skill or ability in decision‐making and be older. The most common strategies used when making all types of decisions were obtaining information on options and recommendations, and getting support from others. Participants preferred to receive information about options through counselling from their physicians, rather than nurses, from printed materials and from discussion groups of people facing the same decision.Conclusion.  The majority of disadvantaged women were actively involved in decision‐making and needed decision support to navigate the healthcare system. Nurses should play a more pivotal role in providing health decision support. This study needs to be replicated in other countries and cultural contexts.