bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of different forms of selenium supplementation on growth and physiological performance of New Zealand white rabbits
Authors: Moustafa Kout-Elkloub M. El. , EL-Hosseiny Hoda M. , Shaheen G. F. , El-Kotamy E. M. , Ghoniem Abd elghani , Younan G. E. , El-Nahrawy M. M. , Farag Mona E. , Mohamed Manal S. 
Published: April 2024

AbstractForty-eight weaned male New Zealand White rabbits aged 6 weeks with an initial body weight of (709.67 ± 13 g) were randomly divided into six experimental groups (8 rabbits each) for 6–14 weeks of age experimental periods. The present study was planned to evaluate the effect of using different forms of Selenium element (inorganic, nanoparticles and organic) as dietary supplementation on productive performance of rabbits. Six experimental groups in completely randomized design were used. The first group (G1, control) was fed the basal diet to cover maintenance and production allowances. Rabbits in the other groups G2, G3, G4 and G5 were fed the basal diet supplemented with Nano- Se at 0.02, 0.03, 0.04 and 0.05 mg/kg diet, respectively. The 6th group (G6) was fed the basal diet supplemented with 0.1 mg/kg diet of salinized yeast (Se-yeast) as organic form. The results indicated that the highest values of nitrogen free extract (NFE) and crude fiber (CF) digestibility, live body weight, daily weight gain, hot carcass weight and dressing percentage were observed with those supplemented with Nano-Se at all levels compared with other treatments. However, feed conversion, net revenue and economic efficiency values were improved with Nano-Se groups followed by organic Se group in comparisons with the control group. Conclusively, the Nano-Se in rabbit’s diet has a positive effect in improving rabbit’s performance and economic efficiency compared to the inorganic Selenium.
Does commercial indoxacarb pose ecotoxicological consequences? Employing a multi-marker approach in the model species Theba pisana
Authors: Radwan Mohamed A. , Gad Amira F. , Abd El-Aziz Amira M. , El-Gendy Kawther S. 
Published: April 2024

AbstractIndoxacarb is one of the most extensively used oxadiazine insecticides worldwide, but it may exert detrimental effects on ecosystems, population dynamics, and health. Due to the lack of knowledge on the ecotoxicity of indoxacarb, it is still challenging to assess whether this insecticide poses an ecotoxicological impact on terrestrial environments. Therefore, our study aims to provide novel data on the toxic effects of 28-day dietary exposure to commercial grade indoxacarb at two environmentally relevant concentrations, 0.02 µg/mL and tenfold (0.2 µg/mL) on the model species, Theba pisana. Their effects were studied using a multiple biomarker approach by evaluating physiological, biochemical, and histopathological responses. After 28 days of treatment, indoxacarb at both concentrations significantly reduced the food intake and growth of the treated snails. Also, it caused decreases in lipid peroxidation (LPO) levels after 7 and 14 days of exposure, whereas an opposite effect occurred after 21 and 28 days. All treated snails were found to exhibit a lower content of glutathione (GSH) after all times of exposure. Moreover, catalase (CAT), glutathione-S-transferase (GST), and glutathione peroxidase (GPx) activities, as well as protein content (PC), were elevated in the treated snails after all time intervals. Post exposure to both realistic indoxacarb concentrations, changes in acetylcholinesterase (AChE) activity between a decrease and an increase were observed. Furthermore, indoxacarb caused histo-architectural changes in the hepatopancreas of T. pisana. Our results demonstrate that, at environmentally relevant concentrations, indoxacarb poses negative consequences for T. pisana, indicating its ecotoxicological impacts.
Graphical Abstract
Implications of mineral price volatility on the outcome of social life cycle assessment interpretation—a battery material case study
Authors: Orola Anni , Uusitalo Ville , Levänen Jarkko 
Published: April 2024

Abstract
Purpose
New research methods are needed to better understand the progress toward social sustainability goals. Social life cycle assessment (S-LCA) is one way to measure this progress, but price volatility may cause challenges in using monetary value-based S-LCA modelling with typical S-LCA databases. To address these methodological concerns, the study focuses on assessing the impacts of price volatility on S-LCA results through a comparative case study on the social risks of battery materials.

Methods
The Social Hotspot Database (SHDB) was used to compare cathode active material (CAM) production in Finland and globally to see how price volatility of minerals impacts the results of comparative S-LCA. Also, a sensitivity analysis was performed on the prices of multiple minerals and energy types used in NMC 811 CAM production.

Results and discussion
This study shows that price volatility might have an unanticipated effect on the results of S-LCA, e.g., by increasing the social risks when the mineral price is decreased due to price volatility. This may cause challenges with interpretation of the results or when results of two different studies using price data from different years are compared with each other, e.g., the results of social product declarations (SPD). However, one of the main purposes of using the SHDB is to find the countries and sectors with the highest social risks in the supply chain, and these results were less sensitive to price volatility except for lithium which also had the highest price fluctuation.

Conclusions
Price volatility can have significant impacts on the results of the monetary value-based S-LCA. It is recommended that the mineral price volatility is considered if developing product category rules for battery-related sectors. The importance of sensitivity analyses should be emphasized, and physical unit-based reference flow should be preferred if site-specific data collection about worker hours is possible.
The impact of the COVID-19 pandemic on symptomatic breast cancer presentations in an Irish breast cancer unit: a retrospective cohort study
Authors: Higgins Áine , O’Reilly Seamus , O’Sullivan Martin J. 
Published: April 2024

Abstract
Background
The coronavirus-19 (COVID-19) pandemic caused delays in the diagnosis and management of breast cancer which may have affected disease presentation. The aim of this study was to compare rates of metastatic disease, tumour characteristics and management in breast cancer patients diagnosed before and after the onset of COVID-19.

Methods
A retrospective chart review was conducted on patients in a university teaching hospital who were diagnosed with invasive symptomatic breast cancer in 2019 (prepandemic control group) and in 2020, 2021, and 2022 (pandemic study groups). Rates of new metastatic presentations, tumour histopathological characteristics, operation type, and therapies administered were statistically compared.

Results
A total of 1416 patients were identified. There was a significant increase in new metastatic breast cancer presentations in 2022 compared to 2019 (14.0% vs 3.8%, p ≤ 0.001), with non-significant increases in 2020 and 2021. Rates of adjuvant radiotherapy increased in 2020 and decreased in 2022 compared to 2019, with no significant change in neoadjuvant or adjuvant chemotherapy rates. Rates of axillary surgery increased during 2020 and 2021. There was an increase in high-grade tumours and lymphovascular invasion (LVI), and less frequent oestrogen receptor (ER) positivity in pandemic groups. No significant change was noted in BCS to mastectomy ratios, overall nodal positivity rates, or median tumour size.

Conclusion
Symptomatic breast cancers diagnosed since the onset of COVID-19 demonstrated an increase in new metastatic presentations and more aggressive histopathological characteristics when compared to a pre-pandemic control group. Rates of adjuvant radiotherapy and axillary surgery increased during the pandemic.
NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury
Authors: Mackiewicz Joanna , Tomczak Julia , Lisek Malwina , Sakowicz Agata , Guo Feng , Boczek Tomasz 
Published: April 2024

AbstractRetinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve, fail to regenerate their axons after injury. The progressive loss of RGC function underlies the pathophysiology of glaucoma and other optic neuropathies, often leading to irreversible blindness. Therefore, there is an urgent need to identify the regulators of RGC survival and the regenerative program. In this study, we investigated the role of the family of transcription factors known as nuclear factor of activated T cells (NFAT), which are expressed in the retina; however, their role in RGC survival after injury is unknown. Using the optic nerve crush (ONC) model, widely employed to study optic neuropathies and central nervous system axon injury, we found that NFATc4 is specifically but transiently up-regulated in response to mechanical injury. In the injured retina, NFATc4 immunolocalized primarily to the ganglionic cell layer. Utilizing NFATc4−/− and NFATc3−/− mice, we demonstrated that NFATc4, but not NFATc3, knockout increased RGC survival, improved retina function, and delayed axonal degeneration. Microarray screening data, along with decreased immunostaining of cleaved caspase-3, revealed that NFATc4 knockout was protective against ONC-induced degeneration by suppressing pro-apoptotic signaling. Finally, we used lentiviral-mediated NFATc4 delivery to the retina of NFATc4−/− mice and reversed the pro-survival effect of NFATc4 knockout, conclusively linking the enhanced survival of injured RGCs to NFATc4-dependent mechanisms. In summary, this study is the first to demonstrate that NFATc4 knockout may confer transient RGC neuroprotection and decelerate axonal degeneration after injury, providing a potent therapeutic strategy for optic neuropathies.
Do photos matter? the effect of hosts’ facial features on customers’ booking intentions in peer-to-peer accommodation: heterogeneity of host gender
Authors: Bai Shizhen , Huang Xinyue , Han Chunjia , Yang Mu , Yu Dingyao , Bi Xinrui 
Published: April 2024

AbstractThis study aims to investigate the effect of hosts’ facial features of different genders on customers’ booking intentions on the Airbnb shared accommodation platform. A comprehensive model was built to analyze hosts’ facial features in the United States (n = 105,084) through big data combined with an artificial intelligence facial recognition system. Results show that beauty, smile, aging, and wearing glasses positively affect customers’ booking intentions. There is gender heterogeneity in the effect of hosts’ facial features on customers’ booking intentions. Compared to female hosts, smiling is significant for male hosts, and wearing glasses has a greater impact on female hosts. Host reputation somewhat weakens the positive effect of host facial features on customers’ booking intentions, and the shared housing type strengthens the positive effect of facial features on customers’ booking intentions. This study provides insights into customer decision-making that may be influenced by hosts’ facial features.
Biomechanical load quantification of national and regional soccer players with an inertial sensor setup during a jump, kick, and sprint task: assessment of discriminative validity
Authors: Bastiaansen Bram J. C. , Vegter Riemer J. K. , Wilmes Erik , de Ruiter Cornelis J. , Goedhart Edwin A. , Lemmink Koen A. P. M. , Brink Michel S. 
Published: April 2024

AbstractTraining load quantification methods may help optimize soccer performance. However, whole-body indicators potentially underestimate biomechanical load. A new inertial sensor setup allows joint-specific biomechanical load quantification. Good discriminative validity further supports the use of this method, and therefore the purpose of this study is to assess the discriminative validity of this method during soccer-specific activities. Twelve national and sixteen regional soccer players wore an inertial sensor setup and performed countermovement jumps, soccer kicks, and 30 m sprints. Between-group differences in angular acceleration-based biomechanical load indicators Knee Load, Hip Load, and performance were assessed using MANOVAs and Cohen’s effect sizes. Furthermore, relationships with performance were explored. National players showed higher Knee Load during jumping (mean difference: 0.11 A.U., ES = 0.93, p = 0.02), kicking (mean difference: 1.94 A.U., ES = 0.94; p = 0.02), and almost during sprinting (mean difference: 12.85, ES = 0.77; p = 0.05). Hip Load did not differ between groups across all tasks, although national players outperformed regional players on all tests. Significant relationships between Knee Load (rjump = 0.41, rkick = 0.65), Hip Load (rjump = 0.42), and performance were observed with 95% confidence intervals ranging from trivial to large. The results confirm discriminative validity of Knee Load for jumping and kicking, but not for sprinting and Hip Load in general. The confidence intervals of the established relationships suggest that the biomechanical loads might not entirely explain between-group differences in performance. The results can be used as reference values for biomechanical load quantification in the field.
Microbes in porous environments: from active interactions to emergent feedback
Authors: Jin Chenyu , Sengupta Anupam 
Published: April 2024

AbstractMicrobes thrive in diverse porous environments—from soil and riverbeds to human lungs and cancer tissues—spanning multiple scales and conditions. Short- to long-term fluctuations in local factors induce spatio-temporal heterogeneities, often leading to physiologically stressful settings. How microbes respond and adapt to such biophysical constraints is an active field of research where considerable insight has been gained over the last decades. With a focus on bacteria, here we review recent advances in self-organization and dispersal in inorganic and organic porous settings, highlighting the role of active interactions and feedback that mediates microbial survival and fitness. We discuss open questions and opportunities for using integrative approaches to advance our understanding of the biophysical strategies which microbes employ at various scales to make porous settings habitable.
The effect of GnRH-a on the angiogenesis of endometriosis
Authors: Filindris Theodoros , Papakonstantinou Efthymia , Keramida Maria , Panteris Eleftherios , Kalogeropoulos Sotiris , Georgopoulos Neoklis , Taniguchi Fuminori , Adonakis George , Harada Tasuku , Kaponis Apostolos 
Published: April 2024

Abstract
Purpose
Neoangiogenesis is necessary for adhesion and invasiveness of endometriotic lesions in women affected by endometriosis. Vascular endothelial growth factor (VEGF) is one of the main components of angiogenesis and is part of the major pathway tissue factor (TF)-protease activated receptor-2 (PAR-2)-VEGF that leads to neoangiogenesis. Specificity protein 1 (SP1) is a transcriptional factor that has recently been studied for its crucial role in angiogenesis via a specific pathway. We hypothesize that by blocking angiogenetic pathways we can suppress endometriotic lesions. Gonadotrophin-releasing hormone-agonists (GnRH-a) are routinely used, especially preoperatively, in endometriosis. It would be of great interest to clarify which angiogenetic pathways are affected and, thereby, pave the way for further research into antiangiogenetic effects on endometriosis.

Methods
We used quantitative real-time polymerase chain reaction (qRT-PCR) to study mRNA expression levels of TF, PAR-2, VEGF, and SP1 in endometriotic tissues of women who underwent surgery for endometriosis and received GnRH-a (leuprolide acetate) preoperatively.

Results
VEGF, TF, and PAR-2 expression is significantly lower in patients who received treatment (p < 0,001) compared to those who did not, whereas SP1 expression is not altered (p = 0.779).

Conclusions
GnRH-a administration does affect some pathways of angiogenesis in endometriotic lesions, but not all of them. Therefore, supplementary treatments that affect the SP1 pathway of angiogenesis should be developed to enhance the antiangiogenetic effect of GnRH-a in patients with endometriosis.

Trial registration
Clinicaltrial.gov ID: NCT06106932.
Working in the Dark? Exploring the Relationship Between the Dark Triad and Early Maladaptive Schemas
Authors: Judith Ray Simone , Fritzon Katerina 
Published: April 2024

AbstractEarly maladaptive schemas (EMS) may contribute to the Dark Triad’s (i.e., Machiavellianism, narcissism, psychopathy) dysfunctional workplace outcomes. EMS — the core concept of Schema Therapy — are entrenched emotional, cognitive, memories, and physiological patterns that form during early life in response to unmet needs and elaborate throughout life. As the workplace can involve hierarchy and power, EMS may be potentially reinforced in this context. This novel study aimed to explore the relationships between EMS and the Dark Triad facets within a working sample. The study also examined whether the Dark Triad facets yield distinct relationships with EMSs. The sample (N = 210) reported working ≥ 20 h per week in paid- or full-time role in private and public sectors. Participants completed an online self-report survey comprising the Young Schema Questionnaire Short Form-Third Edition, Five Factor Narcissism Inventory-Short Form (Antagonism and Extraversion facets), Five Factor Machiavellianism Inventory (Planfulness, Antagonism and Agency facets), and Corporate Psychopathy Inventory-Revised (Boldness, Ruthlessness, and Interpersonal Dominance facets). Zero-order correlations indicated that all Dark Triad facets significantly and positively correlated with the Entitlement/Grandiosity, Unrelenting Standards, and Punitiveness EMSs. Most Dark Triad facets positively correlated with Approval/Recognition Seeking and Mistrust/Abuse EMSs. The Entitlement/Grandiosity EMS demonstrated the strongest positive correlation with most Dark Triad facets. The results suggest that those with elevated Dark Triad traits in the working sample share a similar cognitive and emotional worldview (i.e., EMS) that may activate in the workplace context. Expanding this research could inform a ‘Dark’ Schema Workplace model and Schema Therapy interventions to potentially reduce the Dark Triad’s dysfunctional workplace outcomes.
Early progression is associated with worse survival in patients with Waldenström’s macroglobulinemia
Authors: Xiong Wenjie , Wang Zanzan , Wang Huihan , Li Chunrui , Chu Xiaoxia , Li Bingzong , Yu Ying , Sun Hao , Cao Xinxin , Jiang Zhongxing , Yang Guangzhong , Song Jia , Cai Zhen , Du Juan , Sun Chunyan , Niu Ting , Wei Yongqiang , Xue Hua , Huang Honghui , Li Zhenling , Cui Rui , Qiu Lugui , Li Jian , Yi Shuhua ,   On behalf of Chinese Working Group of Walderström Macroglobulinemia (CWWM)
Published: April 2024

AbstractEarly progression of disease within 24 months (POD24) of diagnosis is associated with inferior overall survival (OS) in follicular lymphoma, but its prognostic role in Waldenström’s macroglobulinemia (WM) is still unclear. Here, we performed a retrospective analysis of 373 patients pooled from the database of the Chinese Registration Network for WM (CRNWM) to determine the outcomes of early progressors. POD24 occurred in 98 evaluable patients (26.3%). The median OS in patients with POD24 was 40 months (95%CI: 15.2–64.0), which was significantly shorter than that without POD24 (156 months, 95%CI: 123.6–188.4; HR: 6.587, 95% CI 4.392–9.881, P < 0.0001). Moreover, subgroup analysis showed that POD24 still maintained its predictive ability of inferior OS in patients treated with rituximab or bortezomib-based treatment. Patients with a very high-risk rIPSSWM stage were more likely to have POD24 (P = 0.020). In conclusion, POD24 was associated with poorer survival and may represent a useful endpoint in future prospective clinical trials.
Effects of microplastics on soil carbon pool and terrestrial plant performance
Authors: Chen Yalan , Li Yang , Liang Xinru , Lu Siyuan , Ren Jiaqi , Zhang Yuqin , Han Zichen , Gao Bo , Sun Ke 
Published: April 2024

AbstractSoil, as a primary repository of plastic debris, faces an escalating influx of microplastics. Microplastics have the potential to decrease soil bulk density and pH, as well as alter soil pore structure and aggregation. These changes in soil physicochemical properties subsequently lead to habitat degradation for microbes and environmental shifts that impact plant growth. Masquerading as soil carbon storage, microplastics can distort assessments of the soil carbon pool by introducing plastic-carbon and associated leachates, influencing soil organic matter (SOM) turnover through priming effects (e.g., dilution, substrate switching, and co-metabolisms). Additionally, microplastics can influence the distribution of soil carbon in particulate and mineral-associated organic matter, consequently affecting the accumulation and stability of soil carbon. Furthermore, microplastics can also influence the chemodiversity of dissolved organic matter (DOM) in soils by increasing DOM aromaticity and molecular weight while deepening its humification degree. The changes observed in soil DOM may be attributed to inputs from microplastic-derived DOM along with organo-organic and organo-mineral interactions coupled with microbial degradation processes. Acting as an inert source of carbon, microplastics create a distinct ecological niche for microbial growth and contribute to necromass formation pathways. Conventional microplastics can reduce microbial necromass carbon contribution to the stable pool of soil carbon, whereas bio-microplastics tend to increase it. Furthermore, microplastics exert a wide range of effects on plant performance through both internal and external factors, influencing seed germination, vegetative and reproductive growth, as well as inducing ecotoxicity and genotoxicity. These impacts may arise from alterations in the growth environment or the uptake of microplastics by plants. Future research should aim to elucidate the impact of microplastics on microbial necromass accumulation and carbon storage within mineral-associated fractions, while also paying closer attention to rhizosphere dynamics such as the microbial stabilization and mineral protection for rhizodeposits within soils.
Graphical Abstract
Prediction of wrinkle patterns in tensioned thin-film structures containing rigid elements
Authors: Sun P. , Huang J. , Zhang J.Y. , Meng F.B. , Zhao P.B. 
Published: April 2024

AbstractWith the in-depth study of thin-film structures, nonuniform thin films with rigid elements have been applied in the aerospace and flexible electronics industries. For thin-film structures with rigid elements, there is an interaction force between the rigid element and the thin film; therefore, the wrinkling mode of the thin film changes under the influence of the interaction force. In this study, a wrinkle model was developed to predict the wrinkle morphology of thin-film structures with rigid elements on the diagonal. First, the wrinkle patterns of the rigid elements were observed at different positions using tensile experiments. Then, the relationship between the tilt of the rigid element and the wrinkle wavelength was investigated using a finite-element eigenvalue buckling analysis. Finally, local wrinkling caused by the perturbed stress of the rigid element was introduced, and a wrinkling model of a square thin film with rigid elements on the diagonal under tension was established. The theoretical analysis results were compared with simulation and experimental results, demonstrating that the model can accurately describe the wrinkle patterns of thin-film structures containing rigid elements on the diagonal under tension.