bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro production of human antibodies specifically reactive with human gastric cancer cells of established lines and autologous tissues
Authors: Takayama Tadatoshi , Sakabe Takashi , Fujii Masashi , Yamada El , Uno Masatsune , Ono Yasushi 
Published: February 2007

AbstractHuman lymphocytes derived from regional lymph nodes adjacent to the primary gastric cancer were transformed with Epstein‐Barr virus (EBV) to establish lymphoblastoid cell lines secreting human antibodies reactive with cell surface antigens expressed on the gastric cancer cells. The EBV transformation technique was applied to lymph node lymphocytes obtained from 4 gastric cancer patients. As a result of mass screening with the radioactive cell binding assay for the production of anti‐gastric cancer related antibodies, one culture (TGc‐106) among 1,400 microcultures was identified to secrete human antibody specifically reactive with an established human gastric cancer cell line as target (MKN‐45). Furthermore, it was demonstrated with the autologous assay system by the histoimmuno‐fluorescence method that cell surface antigens of autologous gastric cancer cells could be clearly defined with human antibody from one culture (TEb‐079) out of 470 microcultures established from a gastric cancer patient (GCP‐26); there was no reactivity against the surrounding normal cells constructing the gastric wall. The immunoglobulin class of the human antibodies produced both in TGc‐106 and TEb‐079 was determined from immunodiffusion tests to be IgM.
Effects of sodium cholate on experimental carcinogenesis and cell proliferation in an excluded colonic segment
Authors: Tempero Margaret A. , Zetterman Rowen K. 
Published: February 2007

AbstractBile salts appear to be important promoters of colon carcinogenesis. This study was designed to assess the importance of the fecal stream in cholic acid‐induced colon tumor promotion. Male Sprague‐Dawley rats underwent transverse colostomy after induction with dimethylhydrazine (DMH) and the excluded distal colon was irrigated with saline or sodium cholate (23 μM) 5 times per week until sacrifice. Controls initially injected with saline were similarly treated. All surviving animals were sacrificed at 28 weeks after the last DMH injection. Five animals from each group were randomly chosen to assess tritiated thymidine labeling and distribution by autoradiography in normal appearing colon mucosa of irrigated bowel. Cholate irrigation failed to increase tumor yield or modify the proportion of adenomas and adenocarcinomas in this model. Paradoxically, fewer tumors per affected rat were noted with sodium cholate irrigation. Cholate irrigation also failed to affect crypt cellularity, thymidine labeling indices, and labeling distribution in DMH‐treated rats and controls. An effect of DMH was seen, however, with an increase in thymidine labeling index and increased labeling in the top half of the crypt in all DMH‐treated groups. This study suggests that tumor promotion with primary bile salts is not a direct affect and may result from further bile salt metabolism within the fecal stream. DMH‐induced changes in cell proliferation were reproduced with this model. Use of an excluded colon segment to assess the effect of suspected tumor promoters on carcinogenesis or colon mucosal cell proliferation is feasible and may be a useful model for future studies.
Survival following self‐administered chemotherapy for liver metastases
Authors: O'dwyer Patrick J. , Minton John P. 
Published: February 2007

AbstractFifty‐three patients with unresectable liver metastases from colorectal cancer either self‐administered or had a family member administer 5‐fluorouracil (5‐FU) (12 mg/kg/day for 5 days in alternate weeks) through intraoperatively placed hepatic artery and/or portal vein catheters. Twenty percent had failed previous systemic chemotherapy. Seventeen who were symptomatic received additional radiotherapy. Metastasis was confined to the liver in 38, while 15 also had extrahepatic metastases. Median survival for those with hepatic metastases only was 21 months from diagnosis and 16 months from catheter insertion. There are three long‐term survivors in this group, alive 58, 69, and 86 months, respectively, from diagnosis. Median survival for those with hepatic and extrahepatic metastases was 10 months from diagnosis and 6 months from catheter insertion. No patient in this group has survived long term. Catheter‐related complications occurred in 20% of the patients; none were fatal. Drug toxicities were minor. Self‐administered chemotherapy is a safe, effective, and simple method of achieving prolonged survival in patients with unresectable hepatic metastasis from colorectal cancer.
Nonosseous sarcomas in a military hospital
Authors: Shaver Timothy R. , Lee Yeu‐Tsu Margaret 
Published: February 2007

AbstractThis is a retrospective review of 67 patients with soft tissue or visceral sarcomas treated during 1973–1982. There were 40 males and 27 females. The mean age was 36 with a range of 1 to 77 years of age. The most common histologic subtypes were rhabdomyosarcoma (19%), malignant fibrohistiocytoma (13%), fibrosarcoma, leiomyosarcoma, dermatofibro‐sarcoma protuberans (12% each), and liposarcoma (10%). Among the 42 soft tissue sarcomas 33% occurred in the trunk, 35% and 21% in the lower and upper extremities, and 10% in the head and neck region. Among the 25 visceral sarcomas, 16% were in the thorax, 56% involved abdominal or retroperitoneal organs, and 28% were in the head and neck region. Overall, 33 of the 54 patients with early sarcomas were treated by surgical resection alone while 21 others had postoperative adjuvant radiotherapy and/or chemotherapy. Factors influencing survival are presented and patterns of metastasis discussed. Overall, 45% of the patients showed metastatic disease either at diagnosis (15%) or duirng the follow‐up period (30%). The lung was involved in two‐thirds of the cases and was the most common site of spread. In patients with rhabdomyosarcoma and malignant fibrohistiocytoma, regional lymph node metastasis was noted in 36% and 17%, respectively.
Malignancy and concomitant primary hyperparathyroidism
Authors: Strodel William E. , Thompson Norman W. , Eckhauser Frederic E. , Knol James A. 
Published: February 2007

AbstractHypercalcemia is associated with a few primary malignant neoplasms and with a variety of tumors that have spread by metastases. Hyperparathyroidism is a diagnosis that is usually not considered in these patients. At our institution, 18 patients with malignant tumors presented over a 6‐year period with hypercalcemia caused by hyperparathyroidism. There were five men and 13 women with a mean age of 48 years (range 24–87 years). Primary tumors in these patients included colon carcinoma (four cases), breast carcinoma (four cases), lymphoma (four cases), thyroid carcinoma (four cases), Paget's disease (one case), and lung carcinoma (one case). Metastases of the primary tumor occurred in seven patients, and in 11 patients the tumor was not metastatic or recurrent. Serum levels of calcium, phosphate, and chloride averaged 11.8 mg/dl, and 100 mEq/liter, respectively. C‐terminal parathyroid hormone (PTH) levels ranged from 300 to 1,900 pg/ml with an average of 1,150 pg/ml (normal 50–340 pg/ml). At operation, a single parathyroid adenoma was discovered in 15 patients, and four‐gland hyperplasia was noted in three patients. In all cases, serum levels of calcium returned to normal after operation. We conclude that patients with malignant tumors and concomitant hypercalcemia should be evaluated for the possibility of hyperparathyroidism. In cases of primary hyperparathyroidism, elevated C‐terminal PTH level should be diagnostic. If hyperparathyroidism is determined to be the cause of hypercalcemia, neck exploration and parathyroidectomy are indicated.
Epitheloid hemangiomatosis mistaken for carcinomatosis
Authors: Goldman Gideon , Ilie Bianca , Kashtan Hanoch 
Published: February 2007

AbstractWe present a unique case of intra and extra‐peritoneal epitheloid hemangioma which was mistaken for diffused carcinomatosis, representing a clinical‐pathological problem, and emphasizing the unpredictable behaviour of this tumour. We are dealing with epitheloid vascular tumours, and briefly touch on the differential diagnosis, the principle of biological, pathological and clinical behaviour. Knowledge of this entity would provide an accurate diagnosis and would hence improve dealing with the problem. The conclusion is that this group of Histiocytoid‐epitheloid vascular lesions have varying biological potential and this unusual functional state represents a large spectrum of cells, from normal to neoplastic endothelium.
The rabbit as an experimental animal for tracheal surgery
Authors: Peleg Haran , Rao Uma N. M. , Emrich Lawrence J. 
Published: February 2007

AbstractThe circumferential resection of the trachea with end‐to‐end anastomosis is a well‐established clinical procedure. Still, some problems remain to be solved, such as the choice of optimal suture material. Dogs are primarily used for experimental work in this field, but are difficult to obtain. This operation was performed on nine rabbits, eight of whom survived to the preplanned date of sacrifice. Two of the survivors were found to have severe stricture at the anastomosis. This study indicates that the rabbit is a suitable experimental animal for circu, ferential resection and anastomosis of the trachea.
Thermal resistance of human malignant melanoma modulated by prostaglandin E2
Authors: Kern David H. , Krag David N. , Kauffman Gordon L. , Morton Donald L. , Storm F. Kristian 
Published: February 2007

AbstractThe inhibition of DNA synthesis in a human malignant melanoma cell line as measured by tritiated thymidine (3H‐TdR) incorporation was both time and temperature dependent. Two components of cell damage were identified: a cytostatic, temporary component from which no was observed. Thermotolerance was induced in M14 cells by sublethal heat treatment at 41°C for 1 hr. However, induction of thermotolerance was blocked by indomethacin, a prostaglandin synthetase inhibitor. Exogenous PGE2 at concentrations up to 10 μg/ml also protected cells from heat damage. These data suggest that prostaglandin synthesis increases during heat stress and may play a role in protecting cells from thermal damage.
Stage I uterine adenosarcoma: A report of six cases
Authors: Baker Trudy R. , Piver M. Steven , Lele Shashikant B. , Tsukada Yoshiaki 
Published: February 2007

AbstractSix cases of Stage I adenosarcoma of the uterus are reported. Although these neoplasms have generally been regarded as being of low malignant potential with little propensity for distant metastasis, our experience reveals some of them to be aggressive tumors with rapid clinical demise. Five (83%) patients demonstrated recurrence after initial surgery, three despite postoperative vaginal radium or external pelvic radiation. Four of the recurrences occurred in the pelvis and abdomen; the fifth was limited to the vagina. Three patients were dead of disease within three years of diagnosis, two of whom achieved clinical remission for at least one year to combination chemotherapy. One of the remaining three patients died from intercurrent disease without recurrence, and two are alive without disease after treatment for recurrence. Based on this limited experience, we believe these neoplasms should be regarded as potentially as malignant as their mixed Miillerian counterpart.
Tumor markers carcinoembryonic antigen, tissue polypeptide antigen, and carbohydrate antigen 19/9 in liver diseases
Authors: Putzki H. , Ledwoch J. , Student A. , Jablonski M. , Heymann H. 
Published: February 2007

AbstractThe tumor markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), and carbohydrate antigen 19/9 (CA19/9) have been compared with regard to their sensitivity to liver diseases. All three markers have been found to be sensitive to liver diseases, but to a different degree: TPA rises the most; CEA the least. The sensitivities of TPA and CA19/9 are higher in a group of liver diseases than, for comparison, in a group of colorectal carcinomas.
Prostatic‐specif IC antigen: Clinical experience utilizing lmmunoperoxidase staining techniques in patients with metastatic prostate cancer
Authors: Baker William C. , Meyers Frederick J. , White Ralph W. Devere 
Published: February 2007

AbstractA human prostatic‐specific antigen was first purified in 1979 by M. C. Wang et al. In the years to follow, investigators have been able to develop antisera to prostatic‐specific antigen. Using an immunoperoxidase technique to stain both fresh and archival specimens, tissue of prostatic origin can be identified. The stain in our experience has been both specific and sensitive as an indicator of extraprostatic spread of carcinoma. We describe five cases where this technique has been useful in clinical practice.
Cytodiagnosis of soft tissue tumors
Authors: Oland Jan , Rosen Ada , Reif Renata , Sayfan Joel , Orda Ruben 
Published: February 2007

AbstractThe only acceptable definitive diagnosis of a soft tissue mass is histologic or cytologic examination. In recent years, fine‐needle aspiration cytology is used in more and more centers for diagnosis of soft tissue masses. We studied 196 aspiration cytologies performed on soft tissue lesions. Out of these, in 48 cases a definitive surgical procedure or open biopsy for histology and further evaluation were performed. There were 25 sarcomas and 23 benign tumors. There was one false negative cytologic result in this group; no false positive cytologies were detected. It seems that cytodiagnosis of soft tissue masses performed by an experienced pathologist is the method of choice, permitting a good diagnostic evaluation, with almost none of the traumatic and oncologic disadvantages of the other methods of biopsy.
Bladder cancer: Pelvic lymphadenectomy revisited
Authors: Herr Harry W. 
Published: February 2007

AbstractThe value of pelvic lymphadenectomy in patients undergoing cystectomy for bladder cancer is controversial. While perhaps 1–2 percent of all patients may be cured after excision of positive nodes, the overall contribution of this procedure to survival is minimal. Pelvic lymphadenectomy is however becoming more valuable for staging and therapy in combination with more effective systemic chemotherapy and its role in the overall management of patients with invasive bladder cancer is presently being redefined.
Metastatic spread of floor of the mouth squamous cell carcinoma via pectoralis major myocutaneous flap
Authors: Badellino F. , Berrino P. , Campora E. , Canavese G. , Galli A. , Margarino G. , Scala M. , Santi P. L. 
Published: February 2007

AbstractIn a patient with recurrent head and neck squamous cell carcinoma, reconstruction of the floor of the mouth was carried out by transposition of a pectoralis major myocutaneous flap after composite resection. Twelve months after surgery, a chest wall metastasis corresponding to the site of the vascular pedicle was observed. It appears that the lymphatic and hematogenous tumor spread can occur along the vascular pathways of a transposed myocutaneous flap.
Anorectal region malignant melanoma
Authors: Kantarovsky A. , Kaufman Z. , Zager M. , Lew S. , Dinbar A. 
Published: February 2007

AbstractA retrospective study of eight patients who had suffered from malignant melanoma in the anorectal region was carried out. The initial presentation, histological findings, treatment, and survival are described. Mean survival was 18 months; however, one patient survived 147 months after initial diagnosis. An inverse correlation was noted between depth of tumor penetration and the number of giant multinucleated cells. No correlation was found between survival and histological findings or therapy regimen.
Intestinal alkaline phosphatase isoenzyme in patients with primary liver cancer during treatment with N10 propargyl 5, 8‐dideazafolic acid (CB 3717)
Authors: Buamah P. K. , Skillen A. W. , Cassells‐Smith A. J. , James O. F. W. , Harris A. L. 
Published: February 2007

AbstractSerum aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma‐glutamyl transferase (γGT) activities and the serum ALP isoenzyme pattern have been measured in eleven patients undergoing treatment with CB3717. There were increases in the activity of all three enzymes. The ALP isoenzyme pattern showed an increased contribution of the intestinal isoenzyme to the serum ALP activity. This may be due to increased intestinal mucosal leakage or impaired uptake and breakdown of the intestinal isoenzyme by the liver.
Excision of the large congenital melanocytic nevus facilitated by the use of the tissue expander
Authors: Wiltz Hector , Kollmer W. Lance , Rauscher Gregory E. , Sharma Parmod K. , Cohen Philip J. , Schwartz Robert A. 
Published: February 2007

AbstractLarge congenital melanocytic nevi both present a cosmetic problem and may predispose to the development of a melanoma. We present a series of three patients in whom the tissue expander was employed to facilitate a large excision with primary closure and excellent cosmesis.
Pelvic exenteration for carcinoma of the cervix: Analysis of 252 cases
Authors: Cuevas Hector Rodriguez , Torres Alfonso , Garza Mario De La , Hernandez Dimas , Herrera Lemuel 
Published: February 2007

AbstractWe present the results of 252 pelvic exenterations for primary and recurrent carcinoma of the cervix at the Hospital General de Mexico, a tertiarycare institution for the indigent. Emphasis is placed on the morbidity and mortality of the procedure in relation to patient selection. In underdeveloped countries, where early detection of cervical cancer is a rare event, pelvic exenteration must continue in the armamentarium of physicians; it can be associated with gains in the quality of life, with long‐term survival, with effective rehabilitation, and possibly with cures.
Ectopic decidua and metastatic squamous carcinoma: Presentation in a single pelvic lymph node
Authors: Cobb Camilla J. 
Published: February 2007

AbstractThe presence of ectopic decidua in pelvic lymph nodes from patients with squamous carcinoma of the cervix makes evaluation for metastatic disease difficult due to the light microscopic similarity between decidua and sheets of squamous epithelial cells. A patient is presented in whom decidualized endometriosis was intimately asssociated with metastatic moderately differentiated squamous carcinoma in a single pelvic lymph node. This phenomenon afforded an excellent opportunity to study the unique morphologic features that distinguish these two entities. A prior report of this kind was not found. In the absence of obvious squamous differentiation (i.e., intercellular bridges, dyskeratosis, and keratin “pearl” formation), as is frequently the case with squamous carcinoma of the cervix, the light microscopic features that are most useful in distinguishing squamous carcinoma from decidua include the presence of well‐defined nests of cohesive cells, nuclear hyperchromasia, and cellular pleomorphism.
Significant prolongation of segmental pancreatic allograft survival in two species
Authors: Du Toit Don F. , Heydenrych Jacobus J. 
Published: February 2007

AbstractA study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL1 in combination with CSA in baboons. Total pancreatectomy in the dog and primate provided a reliable diabetic model, induced an absolute deficiency of insulin and was uniformly lethal if not treated. Continuous administration of CSA in baboons resulted in modest allograft survival. As in baboons, dogs receiving CSA 25 mg/kg/d rendered moderate graft prolongation but a dose of 40 mg/kg/d resulted in significant graft survival (> 100 days) in 5 of 8 allograft recipients. Irradiation alone resulted in minimal baboon pancreatic allograft survival of 20 baboons receiving TL1 1,000 rad and CSA, 3 had graft survival > of 100 days. Of 15 baboons receiving TL1 800 rad and CSA, 6 had graft survival of > 100 days. In conclusion, CSA administration in dogs and TL1 in combination with CSA in baboons resulted in highly significant segmental pancreatic allograft survival.
Carcinoma of possible thymic origin presenting as a thyroid mass: A new subgroup of squamous cell carcinoma of the thyroid
Authors: Kakudo Kennichi , Mori Ichiro , Tamaoki Norikazu , Watanabe Keiichi 
Published: February 2007

AbstractIntrathyroidal thymoma is a rare tumor that occurs in the thyroid gland and has been reported as a low‐grade malignant tumor. The present report describes a 59‐year‐old male patient with this tumor, who was treated with subtotal thyroidectomy followed by radiation and chemotherapy. The tumor was located in the lower pole of the left lobe and the isthmus of the thyroid, and it had invaded the thyroid parenchyma, thyroid capsule, adjacent connective tissue, and neck muscles. Continuity between the cervical thymus and the tumor was noted. Subsequently, the patient developed widespread metastases in the liver, lungs, bones, and lymph nodes without local recurrence. Histologic examination disclosed a solid growth of epithelial cells with squamous cell differentiation and keratinization. The tumor cells had an ill‐defined cell border and large nuclei with large nucleoli. Moderate mitoses and slight necrosis of the tumor were seen. Immunohistochernical examination showed that the tumor cells were stained positively for keratin but not for calcitonin or thyroglobulin. There were infiltrations of lymphocytes in the tumor and fibrous stroma, and most of them proved to be T cells.
Multimodality treatment of non‐small cell lung cancer: Response to cisplatin, VP‐16, and 5‐FU chemotherapy and to surgery and radiation therapy
Authors: Sridhar K. S. , Thurer R. , Kim Y. , Fountzilas G. , Davila E. , Donnelly E. , Charyulu K. K. N. , Saldana M. J. , Thompson T. , Benedetto P. , Raskin N. , Beattie E. J. 
Published: February 2007

AbstractTwenty‐one patients with unresectable non‐small cell lung cancer (NSCLC), 11 with stage III M0, five with malignant pleural effusion, and five with a single resectable metastasis were treated with multimodality therapy. All received two to three cycles of preoperative chemotherapy with a new sequential combination of cisplatin (50 mg/m2 IV×1) followed by 5‐FU infusion (40 mg/m2/hr×72) and etoposide (80 mg/m2/day×3). Thirteen of 21 (62%) had a partial response, and three (14%) had a minor response to chemotherapy. Of the 19 who underwent surgical exploration, 17 were confirmed to have NSCLC. Ten patients with NSCLC and one with choriocarcinoma were rendered disease free by resection of the primary tumor and lymph nodes. Six received intra‐and/or perioperative interstitial therapy with 125I and/or 192Ir. Another patient was treated with 32P. Postoperative external radiotherapy was administered in 15 patients, and adjuvant chemotherapy was administered in ten. This multimodality therapy was well tolerated, safe, and highly effective, resulting in excellent palliation even in patients with pleural effusion and metastasis. The most promising results were in unresectable stage III M0 with a partial response rate of 82% following neoadjuvant chemotherapy and a complete response rate of 73% after surgery. In this group, median survival has not yet been reached and will exceed 12 months.