bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Syntheses of (‐)‐Oleocanthal (Vb), a Natural NSAID Found in Extra Virgin Olive Oil, the (‐)‐Deacetoxy‐Oleuropein Aglycone (IX), and Related Analogues.
Authors: Smith Amos B. III , Sperry Jeffrey B. , Han Qiang 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Colorimetric Recognition of Anions Using Preorganized Tetra‐Amidourea Derived Calix[4]arene Sensors.
Authors: Quinlan Eoin , Matthews Susan E. , Gunnlaugsson Thorfinnur 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Structural Aspects of the Chemistry of V, Mo, W Polyoxometalates
Authors: Fedotov M. A. , Maksimovskaya R. I. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Graphite Whiskers, Cones, and Polyhedral Crystals
Authors: Dimovski Svetlana , Gogotsi Yury 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organoboronic Acids and Organoborinic Acids as Bronsted—Lewis Acid Catalysts in Organic Synthesis
Authors: Ishihara Kazuaki 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coupling Reactions of Areneboronic Acids or Esters with Aromatic Electrophiles
Authors: Suzuki Akira 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Polyketides Using Asymmetric Aldol Reactions
Authors: Paterson Ian 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Cyclic Ketal and Spiroaminal‐Containing Natural Products
Authors: Forsyth Craig J. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Advances in the Treatment of Thromboembolic Diseases: Venous Thromboembolism
Authors: Agrawal Y. K. , Vaidya Hitesh , Bhatt Hardik , Manna Kuntal , Brahmkshatriya Pathik 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
External beam radiation treatment for rectal cancer is associated with a decrease in subsequent prostate cancer diagnosis
Authors: Hoffman Karen E. , Hong Theodore S. , Zietman Anthony L. , Russell Anthony H. 
Published: December 2007

AbstractBACKGROUND.External beam radiation therapy (EBRT) for rectal cancer unavoidably delivers significant radiation dose to the prostate gland. The effect of this incidental exposure on subsequent prostate cancer diagnosis was investigated using the Surveillance, Epidemiology, and End Results (SEER) cancer registry.METHODS.Men diagnosed with localized or regional (L/R) rectal cancer from 1988–1997 and treated with EBRT and sphincter‐sparing surgery (SSS) were identified. Men treated for L/R rectal cancer with SSS who did not receive EBRT, and men with L/R colon cancer who did not receive EBRT, were studied for comparison. Multiple Primary Standardized Incidence Ratios of observed to expected (O/E) cases of prostate cancer were calculated using SEER*Stat.RESULTS.In all, 1574 men with L/R rectal cancer treated with EBRT and SSS were identified. The median age at diagnosis was 64 and median survival was 76 months. Twenty were subsequently diagnosed with prostate cancer, a number significantly less than expected compared with the general population of similar age and race. The ratio of O/E cases was 0.28 (95% confidence interval [CI], 0.17, 0.43). In contrast, 3114 men diagnosed with rectal cancer undergoing SSS who were not treated with EBRT and 24,578 men diagnosed with colon cancer who were not treated with EBRT were subsequently diagnosed with prostate cancer at rates similar to the general population (O/E of 0.94 and 1.09).CONCLUSIONS.EBRT for L/R rectal cancer was associated with a 72% decrease in the frequency of subsequent prostate cancer diagnosis when compared with men of similar age and race. Possible mechanisms that may explain this observation are discussed. Cancer 2008. © 2007 American Cancer Society.
Carboplatin hypersensitivity reaction in pediatric patients with low‐grade glioma
Authors: Lafay‐Cousin Lucie , Sung Lillian , Carret Anne‐Sophie , Hukin Juliette , Wilson Beverly , Johnston Donna L. , Zelcer Shayna , Silva Mariana , Odame Isaac , Mpofu Chris , Strother Douglas , Bouffet Eric 
Published: December 2007

AbstractBACKGROUND.Carboplatin‐based regimens have demonstrated activity in pediatric patients with low‐grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy.METHODS.The objectives of this study were to describe the prevalence, characteristics, and management of Cb HSR and to detail their impact on outcome. The authors conducted a comprehensive, national, retrospective review of children who were diagnosed with LGG between 1985 and 2004 and received treatment with carboplatin.RESULTS.One hundred five patients from 10 Canadian centers were included. The median patient age at diagnosis was 3.5 years (range, 0.3–16.8 years), and 33 patients (31.4%) had neurofibromatosis type 1. Carboplatin was administered monthly in 46 children and weekly in 59 children. Forty‐four patients (41.9%) developed Cb HSR after a median of 10.5 infusions (range, 3–39 infusions). Cb HSR occurred significantly earlier among children on the weekly schedule (4.4 months vs 9.1 months; P = .02). The first allergic reaction was grade I or II in 36 patients (82%). The cumulative incidence of Cb HSR increased with the number of infusions, and there was no evidence of a plateau. The only predictive factor was being a girl rather than a boy (P = .02). Thirty‐four of 44 patients with Cb HSR were re‐exposed to carboplatin, and 24 of 34 patients (70.5%) had recurrent Cb HSR. A desensitization approach did not provide any advantage compared with premedication alone for altering Cb HSR. The median number of additional Cb infusions delivered was 4 (range, 0.5–34 infusions). The effect of Cb HSR on the 5‐year progression‐free survival rate was not statistically significant (P = .1).CONCLUSIONS.Forty‐two percent of children with LGG who received carboplatin regimens experienced Cb HSR. Most rechallenged children had recurrent Cb HSR despite Cb HSR‐altering regimens. Cb HSR did not have an impact on progression‐free survival. Cancer 2008. © 2007 American Cancer Society.
Six cadm/synCAM genes are expressed in the nervous system of developing zebrafish
Authors: Pietri Thomas , Easley‐Neal Courtney , Wilson Catherine , Washbourne Philip 
Published: December 2007

AbstractThe Cadm (cell adhesion molecule) family of cell adhesion molecules (also known as IGSF4, SynCAM, Necl and TSLC) has been implicated in a multitude of physiological and pathological processes, such as spermatogenesis, synapse formation and lung cancer. The precise mechanisms by which these adhesion molecules mediate these diverse functions remain unknown. To investigate mechanisms of action of these molecules during development, we have identified zebrafish orthologs of Cadm family members and have examined their expression patterns during development and in the adult. Zebrafish possess six cadm genes. Sequence comparisons and phylogenetic analysis suggest that four of the zebrafish cadm genes represent duplicates of two tetrapod Cadm genes, whereas the other two cadm genes are single orthologs of tetrapod Cadm genes. All six zebrafish cadms are expressed throughout the nervous system both during development and in the adult. The spatial and temporal patterns of expression suggest multiple roles for Cadms during nervous system development. Developmental Dynamics 237:233–246, 2008. © 2007 Wiley‐Liss, Inc.
Relaxation methods and coupling procedures
Authors: Ambroso A. , Chalons C. , Coquel F. , Godlewski E. , Lagoutière F. , Raviart P.‐A. , Seguin N. 
Published: December 2007

AbstractThis paper studies a global relaxation method to ensure the conservative coupling at a fixed interface of two Euler systems with different pressure laws. Copyright © 2007 John Wiley & Sons, Ltd.
The ectonucleotidase cd39/ENTPDase1 modulates purinergic‐mediated microglial migration
Authors: Färber Katrin , Markworth Sören , Pannasch Ulrike , Nolte Christiane , Prinz Vincent , Kronenberg Golo , Gertz Karen , Endres Matthias , Bechmann Ingo , Enjyoji Keiichi , Robson Simon C. , Kettenmann Helmut 
Published: December 2007

AbstractMicroglia is activated by brain injury. They migrate in response to ATP and although adenosine alone has no effect on wild type microglial migration, we show that inhibition of adenosine receptors impedes ATP triggered migration. CD39 is the dominant cellular ectonucleotidase that degrades nucleotides to nucleosides, including adenosine. Importantly, ATP fails to stimulate P2 receptor mediated migration in cd39−/− microglia. However, the effects of ATP on migration in cd39−/− microglia can be restored by co‐stimulation with adenosine or by addition of a soluble ectonucleotidase. We also tested the impact of cd39‐deletion in a model of ischemia, in an entorhinal cortex lesion and in the facial nucleus after facial nerve lesion. The accumulation of microglia at the pathological sites was markedly decreased in cd39−/− animals. We conclude that the co‐stimulation of purinergic and adenosine receptors is a requirement for microglial migration and that the expression of cd39 controls the ATP/adenosine balance. © 2007 Wiley‐Liss, Inc.
Observations of initiation stage of spontaneous vapor explosions for droplet scale
Authors: Takashima Takeo 
Published: December 2007

AbstractIn this study, the initiation stage of spontaneous vapor explosions generated by single droplets of molten tin submerged in water was investigated using a high‐ speed video camera operated with a reflected light system. Photographs of the formation process of vapor film, the process of vapor film disturbance, and the initiation process of the vapor explosions for different masses of molten tin and different nozzle diameters were obtained. The results demonstrate that partial thermal interaction between tin and water does not cause a vapor explosion with fragmentation. The vapor film disappears locally during the formation of the vapor film around the hot liquid droplet. Direct contact between the hot molten tin surface and water is thereby generated. However, the local disappearance of the vapor film does not progress and the vapor film is reconstructed. A vapor explosion occurs when the vapor film collapses at the local area of the bottom or edge of the disk‐shaped droplet. © 2007 Wiley Periodicals, Inc. Heat Trans Asian Res, 37(1): 41–55, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20185
On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations
Authors: Simon Richard , Zhang Xinan 
Published: December 2007

AbstractWe used mathematical models to analyze the age‐incidence curve of breast carcinoma for individuals carrying a germline mutation in the BRCA1 or BRCA2 gene locus. Although many genomic abnormalities have been identified in breast tumors, we found that a two‐stage model fit the data well. A one‐hit model was not, however, consistent with the data. The results supported the hypothesis that the first hit represents loss of the wild type BRCA1 or BRCA2 allele as this occurs at a rate very similar to that for loss of the wild‐type RB allele in retinoblastoma. Loss of the wild‐type BRCA1 or BRCA2 allele appears to destabilize the genome as the second event occurs at a much higher rate. The second event is “rate limiting” in the sense that its occurrence is constrained by the limited number of intermediate cells with doubly mutated BRCA1 or BRCA2 alleles. The second event may not be unique, however. Loss of the wild‐type BRCA allele appears to result in an increased rate for subsequent genomic events. A second event increasing proliferation of the partially malignant intermediate clone may lead inexorably to production and selection of cells with additional mutations in genes that facilitate tumor progression. © 2007 Wiley‐Liss, Inc.
In vivo behavior of a novel injectable calcium phosphate cement compared with two other commercially available calcium phosphate cements
Authors: Hannink Gerjon , Wolke Joop G. C. , Schreurs B. Willem , Buma Pieter 
Published: December 2007

AbstractThe aim of this study was to investigate the physicochemical and biological properties of a newly developed calcium phosphate cement (CPC). The novel cement was compared with two other commercially available CPCs. After mixing the powder and liquid phase, the CPCs were injected as a paste into a rabbit distal femoral defect model. The CPCs were evaluated after 24 h, 6 weeks, 26 weeks, and 52 weeks. The novel CPC was easy to handle and was fast setting. X‐ray diffraction (XRD) and Fourier Transform Infrared Spectrometry (FTIR) at the different implantation periods showed that the cement had converted to carbonated hydroxyapatite and remained stable over time. Histological evaluation showed bone apposition on the cement surface without any inflammatory response or fibrous encapsulation. At later time points, all CPCs were completely covered by a thin layer of bone. Osteoclast‐like cells present at the interface resorbed parts of the cement mass. Histological and histomorphometrical analyses did not show any significant differences between the three implanted CPCs. The results indicate that the investigated CPC is biocompatible, osteoconductive, as well as osteotransductive and seems to be both biologically safe and effective as a bone void filler. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Approaches for prevention of restenosis
Authors: Kraitzer Amir , Kloog Yoel , Zilberman Meital 
Published: December 2007

AbstractCoronary artery disease is characterized by a narrowing (stenosis) of the arteries that supply blood to the tissue of the heart. Continued restriction of blood flow manifests itself as angina and ultimately myocardial infarction (heart attack) for the patient. Heart bypass was once the only treatment for this condition, but over the years percutaneous coronary intervention (PCI) has become an increasingly attractive alternative to medical therapy and surgical revascularization for the treatment of coronary artery disease. A vascular stent is a medical device designed to serve as a temporary or permanent internal scaffold, to maintain or increase the lumen of a blood vessel. Metallic coronary stents were first introduced to prevent arterial dissections and to eliminate vessel recoil and intimal hyperplasia associated with PCI. Further advancement in the treatment of coronary artery disease is the development of drug‐eluting stents that dramatically reduce the incidence of in‐stent restenosis to less than 5%. Local drug delivery offers the advantages of allowing a relatively high local concentration of drug at the treatment site while minimizing systemic toxic effect. This review describes approaches for prevention of restenosis. It focuses on drugs for prevention of restenosis, bare metal stents, and drug‐eluting stents. It also describes recent advances in bioresorbable stents. One of the chapters is dedicated to our novel composite bioresorbable drug‐eluting fibers, designed to be used as basic elements in drug‐eluting stents. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Preparation and characterization of infection‐resistant antibiotics‐releasing hydrogels rods of poly[hydroxyethyl methacrylate‐co‐(poly(ethylene glycol)‐methacrylate]: Biomedical application in a novel rabbit penile prosthesis model
Authors: Arıca M. Yakup , Tuğlu Devrim , Başar M. Murad , Kılıç Dilek , Bayramoğlu Gülay , Batislam Ertan 
Published: December 2007

AbstractIn this work, preparation and characterization of novel three different antibiotic loaded penile prosthesis in the rod form were investigated by copolymerization of 2‐hydroxyethylmethacrylate (HEMA) with poly(ethylene glycol)‐methacrylate, (PEG‐MA). To achieve this goal, a series of novel copolymer hydrogels were prepared in rod form using HEMA and PEG‐MA monomers via UV initiated photopolymerization. The thermal stability of the copolymer was found to be lowered by increase in the ratio of PEG‐MA in the rod structure. Contact angle measurements on the surface of copolymer hydrogel demonstrated that the copolymer gave rise to a significant hydrophilic surface compared with pure poly(HEMA). The blood protein adsorption and platelet adhesion were significantly reduced on the surface of the copolymer hydrogels compared with control pure poly(HEMA). Poly(HEMA:PEG‐MA;1:1)‐1 formulation containing different antibiotics (20 mg antibiotic/g polymer) released about 90, 91, and 55% of the total loaded cephtriaxon, vancomycin, and gentamicin in 48 h at pH 7.4, respectively. Finally, antibiotics loaded biocompatible poly(HEMA:PEG‐MA;1:1)‐1 hydrogel compositions was used as a penile prosthesis in preventing cavernous tissue infections in a rabbit prosthesis model. The efficacy of the three different antibiotics loaded hydrogel system was evaluated in four different groups of rabbits, in which various infectious agents were inoculated. The animals were sacrificed after predetermined time periods, and clinical, histological and microbiological assessment on the implant side were carried out to detect infections. Eventually, we concluded that three different antibiotic loaded penile prostheses (i.e. poly(HEMA:PEG‐MA;1:1)‐1 hydrogel systems) were as effective as parenteral antibiotics applications. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Bone healing response to an injectable calcium phosphate cement with enhanced radiopacity
Authors: Acarturk Oguz , Lehmicke Michael , Aberman Harold , Toms Derek , Hollinger Jeffrey O. , Fulmer Mark 
Published: December 2007

AbstractThe aim of this study was to determine the impact of barium sulfate on remodeling and regeneration in standard tibial defects in rabbits treated with the Norian skeletal repair system (SRS). Two formulations of SRS (with and without barium sulfate) were injected into the medullary canal of the tibia of New Zealand white rabbits. Animals were sacrificed at 6 weeks, 6 months, 1 year, and 2 years. Over the 2‐year duration of the study, standard SRS and SRS with barium sulfate appeared to be biocompatible and osteoconductive with no evidence of either inflammation or fibrous tissue around the implant materials or at the bone‐material interfaces. This outcome underscores the osteophilic property of the SRS. A difference we observed between the standard SRS and the SRS with barium sulfate was the appearance of acellular material contiguous to the SRS with barium sulfate. Energy dispersive X‐ray spectroscopy (EDX) analysis was conducted and confirmed that the acellular material was barium sulfate. Pathological examination of additional tissues including regional lymph nodes revealed neither dissemination of calcium phosphate nor barium sulfate. We concluded that the residual barium sulfate detected by EDX was localized to the intramedullary canal of the tibia. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Anti‐inflammatory effect of ibuprofen‐loaded embolization beads in sheep uterus
Authors: Wassef Michel , Pelage Jean‐Pierre , Velzenberger Elodie , Namur Julien , Schwartz‐Cornil Isabelle , Taylor Rachel R. , Lewis Andrew L. , Laurent Alexandre 
Published: December 2007

AbstractEmbolization of blood vessels may result in a variety of side effects which can include pain and inflammation. The objective of this study was to assess the release and effect of ibuprofen (IBU) from Bead Block™ microspheres (BB) loaded with IBU (IBU‐BB) on the foreign body inflammatory reaction in a sheep uterine artery model. Both uterine arteries of 12 hormonally cycled ewes were embolized with 0.5 mL of 500–700 μm BB (n = 6) or IBU‐BB (n = 6). Animals were sacrificed at 1 week (1W) or 3 weeks (3W) (n = 3 each group). The gross examination of the organs was performed and distribution of the beads in the tissue was assessed. Inflammation was estimated histologically by quantitative and semiquantitative classification of inflammatory cells on HES and MGG stains and use of videoanalysis after immunohistolabeling with CD‐antibodies to a variety of inflammatory cells. At 1W, a significant decrease of inflammatory response was observed for IBU‐BB relative to BB in terms of number of lymphocytes and of immunohistochemical staining for CD172a, MHC‐II, CD3, and CD4. At 3W, the inflammatory response for IBU‐BB was similar to that for BB at 1W in terms of cell populations and moderate intensity. There was no or low amounts of staining for CD8 and CD45RA and none for CD21 in all four groups. Immunohistochemical detection of IBU showed that some drug was still present in the beads at 1W but none was detectable at 3W suggesting it had all eluted. These results signify that the inflammatory response is dampened by the action of IBU eluted from the beads and that IBU‐BB can delay postembolization inflammatory reaction. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008