bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chlorisotopenaustausch bei organischen verbindungen, II(1) hexachlorpropen und alcl3‐36Cl
Authors: Boberg Friedrich , Kirchhoff Klaus , Schultze Georg Richard 
Published: October 2006

AbstractEs ist der Chloraustausch zwischen Hexachlorpropen und Aluminiumchlorid‐[36Cl] untersucht worden. Austausch ist in 1‐, 2‐und in 3‐Stellung am Chlorolefin möglich, entscheidend sind die Reaktionsbedingungen1) In Methylenchlorid trilt in homogener Lösung der Austausch in 1‐ und in 3‐Stellung ein. Diese Reaktion verläuft nach einem Carbeniummechanismus, der näher diskutiert wird. In Übereinstimmung mit den gebrachten Vorstellungen wird der Austausch durch Elektronendonatoren behindert. Erste Untersuchungen hierzu mit Furan, Tetrahydrofuran, Dioxan und Tetrahydropyran werden mitgeteilt. Die energetische Bevorzugung des Carbeniumions zeigt sich auch im Massenspektrum.2) Am festen Aluminiumchloridkristall wird auch das Chlor am Kohlenstoffatom 2 des Chlorolefins ausgetauscht.Bei markierten Hexachlorpropenen wird die Stellung des 36Cl durch Überführung des Chlorolefins‐[36Cl] in Trichloracrylsäure‐[36Cl] festgelegt.Der Versuchsteil enthält Angaben zur Herstellung von AlCl3‐[36Cl], Hexachlorpropen‐[36Cl], Trichloracrylsäure‐[36Cl]. Die Apparatur zur Gewinnung von AlCl3‐[36Cl] aus Aluminium und HCl‐[36Cl] wird näher beschrieben. Aktivitäten sind mit der Flüssigkeitsscintillations‐Methode und dem Geiger‐Müller‐Flüssigkeits‐zählrohr bestimmt worden.
Radiolysis of binary mixtures. Part VIII. Tritium Labelling by direct radiation synthesis. The methanol‐benzene system
Authors: Ekstrom A. , Garnett J. L. 
Published: October 2006

AbstractA novel synthesis of tritiated compounds is reported using the direct irradiation of an aromatic‐aliphatic mixture, one of the components of which is labelled with tritium. The irradiation of the methanoltritiated benzene system has been used to illustrate the principle of the technique. The gamma irradiation of methanolic solutions of tritiated benzene yields the following tritiated scavenging products, some of which are specifically labelled under certain conditions : anisole; 1,3 –‐ and 1,4‐cyclohexadienes; 2,5‐phenylcyclohexadiene; 1,3‐ and 1,4‐cyclohexadiene‐methanols. The potential of the method as a general tritium labeling tool is discussed and compared with conventional procedures. Although the absolute yields of the labelled products from direct irradiation are small for relatively large total radiation doses (megarads), scavenging by non‐labelled parent material can be used to give large chemical yields if required. The predominant advantage of the present method is that compounds labelled in specific positions with tritium can be obtained in a one‐step chemical process whereas this synthesis may be difficult by other conventional labelling methods.
Synthesis of 14C‐labeled olefins using the wittig reaction
Authors: Muhs M. A. 
Published: October 2006

AbstractThe Wittig synthesis has been used to prepare conveniently carbon‐14 labeled 1‐olefins in the C5 to C8 range in about 60 % yield. The chemical and radiochemical purities of the products exceeded 99.5 %. The common source of carbon‐14 in these reactions was methyl‐14C‐triphenylphosphonium iodide which was readily and quantitatively prepared from commercially available methyl‐14C iodide.
Spurious isotope effects in enzymatic reactions with tritium labelled substrates
Authors: Oldham K. G. 
Published: October 2006

AbstractTritium labelled substrates are commonly used in enzyme assays on account of their high specific activity, cheapness and availability. Because of certain special effects occurring with tritium labelled compounds, isotope effects may erroneously be inferred from rate measurements using these compounds. These special effects, and recommended methods of detecting and eliminating them, are discussed.
Synthèse biologique d'acide quinique 14C uniformément marqué
Authors: Boudet A. 
Published: October 2006

Uniformly 14C‐labelled quinic acid has been biosynthesized by exposing young Quercus pedunculata Ehrh leaves to a source of light in a 14CO2 atmosphere. A preliminary study of the change in specific radioactivity of the labelled acid with time has led to a determination of the optimum metabolisation time. After extraction, separation over ion‐exchange resins and purification by preparative chromatography have allowed to obtain from 10 mCi of Ba14CO3 0,26 mCi of quinic acid, the radiochemical purity of which was proved by autoradiography.L'acide quinique 14C uniformément marqué a été synthétisé en exposant à la lumière, en présence de 14CO2, des jeunes feuilles de Quercus pedunculata Ehrh. L'étude de l'évolution, en fonction du temps, de la radioactivité spécifique de l'acide marqué a conduit à déterminer un temps de métabolisation optimum. Aprés extraction, la séparation sur résines échangeuses d'ions et la chromarographie préparative ont permis d'obtenir à partir de 10 mCi de Ba14CO3, 0,26 mCi d'acide quinique radiochromatographiquement pur.
Self‐radiolysis of tritiated compounds
Authors: Guarino A. , Pizzella R. , Possagno E. 
Published: October 2006

AbstractThe self‐radiolysis of a tritiated organic compound has been studied with particular attention to the determination of its percent decomposition, its G(‐M)value, as well as yields of the radiolysis products.Reliable figures have been obtained with the use of accurate experimental techniques, in particular the reverse isotopic dilution method coupled to preparative gas‐chromatography.
Preparation of radioisotopically labelled S‐ribosyl‐l‐Homocysteine
Authors: Duerre John A. , Miller H. 
Published: October 2006

AbstractS‐Ribosyl‐L‐homocysteine radioisotopically labelled in specific moieties has been prepared by enzymatic hydrolysis of the glycosyl bond of sulfur‐35 or tritium‐labelled S‐adenosyl‐L‐homocysteine. Procedures for chromatographic purification and analysis are reported.
Tritium labelling of compounds by exchange in strongly basic media
Authors: Jones J. R. 
Published: October 2006

AbstractA large body of organic compounds containing carbon‐hydrogen bonds have very feeble acidic properties. In order that these compounds be made to ionise it is necessary to employ highly basic media. Recent developments now result in the use of several such systems, some of which can serve as a convenient source of labelling. The possibilities of the method are outlined together with the limitations, and a number of specific examples illustrating how compounds can be labelled are given.
The preparation of uniformly labeled cyclohexylamine and cyclamate
Authors: Alter A. , Forman J. C. 
Published: October 2006

AbstractAniline uniformly labeled with 14C was reduced, in the presence of Rhodium on Alumina catalyst, to cyclohexylamine. The cyclohexylamine was converted to uniformly labeled sodium cyclamate. The overall radiochemical yield was 34 %.
Synthèse de la DL‐Ephedrine (Hydroxyméthylène 14C)
Authors: Nguyen‐Hoang‐Nam  , Herbert M. , Nguyen‐Dat‐Xuong  , Pichat L. 
Published: October 2006

AbstractLa DL‐éphédrine (hydroxyméthylène 14C) a été synthétisée à partir de Ba14CO3 en 5 stades. Après 2 purifications successives par chromatographie sur colonne de partage‐silicagel et sur résine échangeuse d' AG 50W‐X2, on obtient la DL‐éphédrine (hydroxyméthylène 14C) HCl avec un rendement radioactif de 30 % par rapport à Ba14CO3 (activité spécifique : 17 mCi/mM). L'analyse par électrophorèse sur papier en tampon borate de sodium pH 9,2, associée à la chromatographie sur papier et à la chromatographie en couche mince, permet de contrǒler la pureté radiochimique de la DL‐éphédrine 14C.
Synthese von 14C‐markiertem Polyvinylpyridin‐N‐oxid
Authors: Maul W. 
Published: October 2006

AbstractPolyvinyl‐pyridin‐N‐oxid ist eine hochmolekulare Verbindung, die eine therapeutische Wirkung auf die experimentelle Silikose hat. Für biologische Untersuchungen wurde 14C‐markiertes Polyvinylpyridin‐N‐oxid hergestellt. Die Synthese verlief über folgende Stufen : 2‐(2′‐Pyridyl)‐essigsäureäthylester‐[1‐14C], 2‐(2′‐Pyridyl)‐äthanol‐[1‐14C] und 2‐Vinylpyridin‐[vinyl‐2‐14C]. Letzteres wurde polymerisiert und oxydiert zu Polyvinylpyridin‐N‐oxid‐[vinyl‐2‐14C]. Eine fraktionierte Fällung dieses Produktes lieferte Präparate mit einem mittleren Molekulargewicht von 7 000 bis 570 000.
Some factors involved in the decomposition of labeled steroids during storage
Authors: Geller Lawrence E. , Silberman Norman 
Published: October 2006

AbstractEstrone,6‐7‐3H in benzene has been found to exhibit greater decomposition when stored at −5 °C than when stored at +5 °C. The reason is attributed to lack of uniform dispersal of the solute due to solvent crystallization. The non‐distillable residues from commercial solvents have been found to cause rapid destruction of a stored radiochemical if not removed before storage. Data is presented which indicates that the best method for reducing the total amount of decomposition of labeled steroids which are stored for extended periods of time is repurification at regular time intervals.
Synthesis of kryptogenin‐26‐14C and diosgenin‐26‐14C
Authors: Bennett Raymond D. , Sauer Horst H. , Heftmann Erich 
Published: October 2006

AbstractKryptogenin‐26‐14C (13) was synthesized from dihydrodiosgenin diacetate (1). The radioactive carbon atom was introduced by the Arndt‐Eistert method, and the extra carbon atom was then removed by a carboxy‐inversion reaction. Diosgenin‐26‐14C (14) was prepared by reduction of kryptogenin‐26‐14C.
Synthese von 14C‐markiertem noxiptilin
Authors: Maul Walter 
Published: October 2006

AbstractNoxiptilin ist ein neues Antidepressivum mit geringen Nebenwirkungen. Für die Untersuchung des Stoffwechsels und der Kinetik dieser Substanz im Organismus der Ratte wurde ein Kohlenstoff‐14C‐markiertes Noxiptilin benötigt. Die Synthese ging aus vom Bariumcarbonat‐14C (10 mMol; 387 mCi) und führte über die Stufen der o‐ Toluylsäure‐[carboxyl‐14C], Phthalsäure‐[carboxyl‐14C], Benzalphthalid‐ [14C2] zu 2‐ Phenyl‐acetyl‐[carbonyl‐14c]‐benzoe‐säure‐[carboxyl‐14C], die zu 2‐ Phenyl‐äthyl‐[1‐14‐C]‐benzoesäure‐[carboxyl‐14C] hydriert wurde. Hieraus konnte 5H‐Dibenzo [a, d] cyclohepta‐1,4‐dien‐5‐on‐[5,10‐14C2] hergestellt werden, dessen Kondensation mit O‐(β‐Dimethylaminoäthyl)‐hydroxylamin zu 5‐(2‐Dimethylaminoäthyl‐oxyimino) ‐5 H‐dibenzo[a,d] cyclohepta‐1, 4‐dien [5,10‐14C2] führte. Die radiochemische Ausbeute an dem Hydrochlorid dieser Verbindung (Noxiptilin‐14C) betrug 31,5 %. Bei der Aufbewahrung der Substanz, deren spez. Aktivität 117 μCi/mg betrug, in Äthanol im Kühlschrank stieg der Prozentsatz der radioaktiven Verunreinigungen von 0,6 auf 4,2 %.
Validity of tritium tracers. Stability of tritium atoms in purines, pyrimidines, nucleosides and nucleotides
Authors: Anthony Evans E. , Sheppard Hilary C. , Turner John C. 
Published: October 2006

AbstractThe effect of pH and temperature on the stability of tritium atoms at various positions in purines, pyrimidines, nucleosides and nucleotides is discussed. The importance of recognizing several types of instability is stressed.The formation of a hydrate on storing solutions of tritiated uridine and other results of the self‐radiolysis of tritiated precursors of the nucleic acids are described. Alcohol solutions and low temperatures are recommended for minimising self‐decomposition.
Chemical graphs. IX. Isotope‐isomerism of multiply‐labelled compounds
Authors: Balaban A. T. , Fǎrcasiu D. , Harary F. 
Published: October 2006

AbstractGeneralizations of previous figure‐counting series used in Pólya's enumeration theorem are exploited to enable us to predict the number of isomers of multiply‐labelled compounds. Nomenclature problems for such isotope‐isomers are reviewed.
A study of the stability and radiochemical purity of some radiopharmaceuticals
Authors: Rybakow Z. , Cífka J. 
Published: October 2006

AbstractThe thermal and radiation stability of diiodofluorescein were studied. The decomposition products were separated by paper chromatography. Inorganic iodine, mono‐, tri‐ and tetrafluorescein were found as thermal decomposition products of diiodofluorescein. In addition, fluorescein and two unidentified compounds were separated from gamma‐irradiated solutions of diiodofluorescein. The yields of radiation decomposition of diiodofluorescein and formation of monoiodofluorescein and inorganic iodine were estimated as a function of the concentration of diiodofluorescein.
New possibilities of enzymic synthesis of radioactive nucleotides. III. Preparative synthesis of radioactive 5′‐nucleotides by an unpurified cell‐free extract of mouse leukemic cells
Authors: Nejedlý Z. , Hrušková S. , Hybσ K. , Filip J. , Cihák A. , Veselý J. 
Published: October 2006

AbstractAKR leukemic mouse cells possess a considerable uridine kinase activity. The ability of unpurified cell‐free extracts prepared from these cells to phosphorylate nucleosides‐14C was investigated. The substrate specificity of the enzyme preparation and the possibility to regulate the course of the enzymatic reactions were examined. The method is convenient for the preparative synthesis of uracil, cytosine and hypoxanthine 5′‐nucleotides‐14C.
Synthesis of olivetol‐4,6−14C2, and its conversion to (–)–δ9‐6a, 10a‐trans‐tetrahydrocannabinol‐2,4−14C2 via (–)–Δ8‐6a, 10a‐trans‐tetrahydrocannabinol‐2,4−14C2
Authors: Liebman A. A. , Malarek D. H. , Dorsky A. M. , Kaegi H. H. 
Published: October 2006

AbstractOlivetol‐4,6−14C2 (III) was prepared by condensing diethyl‐malonate‐2−14C with 3‐nonen‐2‐one followed by hydrolysis, decar‐boxylation and oxidation. Reaction with (+)‐trans‐p‐menthadien‐2,8‐ol‐l provided (–) — Δ86a, 10a‐trans‐tetrahydrocannabinol‐2,4−14C2 (IV) which was isomerized to (–) — Δ9‐6a, 10a‐trans‐tetrahydrocannabinol‐2,4−14C2 (V). On a scale of 3–5 mmole, malonate‐2−14C yields 45–50% of chromatographically pure olivetol‐4,6−14C2, which on a 2 mmole scale, gave a 56% radiochemical yield of purified tetrahydrocannabinols. Both the (–) — Δ8‐THC‐2,4−14C2 and (–) — Δ9‐THC‐2,4−14C2 had greater [α]D than previously reported.
Synthesis of 15N labelledl alkaloids: Coniine−15N and nicotine‐1′−15N
Authors: Leete E. , Isaacson H. V. , Durst H. D. 
Published: October 2006

AbstractConiine−15N was obtained by the reductive amination of 5‐oxcoctanal using sodium cyanoborohydride and ammonium−15N bromide. Nornicotine‐l'−15N resulted from a similar reductive amination of 4‐oxo‐4‐(3′‐pyridyl)butanal. Methylation with formaldehyde and formic acid afforded nicotine‐l'−15N.
Synthesis of tritium labeled isoxsuprine hydrochloride
Authors: Madding G. D. 
Published: October 2006

AbstractTritium labeled isoxsuprine hydrochloride was required for drug metabolism studies in these laboratories. This compound was prepared specifically labeled with tritium in the 1‐position by the catalytic reduction of racemic β(R), γ(R)‐ and β(S), γ(S)‐p‐hydroxy‐α‐(1‐phenoxy‐2‐propylamino)‐propiophenone hydrochloride with tritium.
Markierte verbindungen XI. chloraustausch zwischen 3H‐pentachlor‐1‐propen und AlCl3–(36Cl), das tetrachlorpropenylium‐ion
Authors: Boberg Friedrich , Khalaf Hosni 
Published: October 2006

AbstractThe tetrachloropropenylium‐ion is proved as intermediate for the exchange of chlorine between 3H‐pentachloro‐1‐propene and AlCl3–(36Cl). The exchange is preferred on C‐3. Chlorine of trichloroacrolein is exchanged with HCl in H2SO4‐solution. — 36Cl‐labelled C3‐compounds have been synthesized.
The synthesis of l‐amino acids and their derivatives labelled with 3H
Authors: Brundish D. E. , Elliott D. F. , Wade Roy 
Published: October 2006

AbstractMethods have been devised for the synthesis of a range of L‐amino acids and of certain of their derivatives and of D‐serine labelled with 3H at their α‐carbon atoms by a racemisation method followed by enzymic resolution. Conditions have been found which allow good recovery of materials of high specific activity for a given outlay of isotope with the added advantage that experimental technique has been maintained to the simplest level possible The stereochemical purity of the labelled amino acids synthesized is in excess of 99.99%.The 3H‐labelling method for determining C‐terminal residues in peptides developed by Matsuo(1) has been briefly investigated.
Synthesis and characterization of carbon‐14 labelled 4, 4′‐ diaminodiphenyl sulfone (dapsone‐14C; DDS‐14C)
Authors: Blackburn C. E. , Glazko A. J. 
Published: October 2006

Abstract4, 4′‐Diaminodiphenyl‐14C sulfone Named as 4, 4′‐sulfonyldianiline in Chemical Abstracts.
(DDS‐14C) was synthesized in four steps. Uniformly carbon‐14 labelled aniline hydrochloride was first acetylated to yield acetanilide (phenyl‐14C). This was coupled with SOCL2 and AlCl3 in a Friedel‐Crafts reaction to yield 4, 4′‐diacetamidodiphenyl‐14C sulfoxide. Oxidation with hydrogen peroxide yielded 4, 4′‐diacetamidodiphenyl‐14C sulfone (DADDS‐14C. Hydrolysis of DADDS‐14C in HCL yielded DDS‐14C. Characterization data are included.
Synthese du methyl‐2 p‐chlorophenyl‐4 pentane diol‐2,4(fenpentadiol) marque AU 14C
Authors: Noël J. P. , Benakis A. , Valette R. , Herbert M. , Pichat L. 
Published: October 2006

AbstractMethyl‐2 p‐chlorophenyl‐4 pentane diol 2,4 14C‐4 (Rd 292‐Fenpentadiol), a psychotropic drug, was prepared by means of the action of methyl magnesium iodure on p‐chlorophenyl‐3 hydroxy‐3 ethyl butyrate 14C‐3. The latter was obtained by means of the Reformatzri reaction between ethyl bromoacetate and p‐chloroacetophenon 14CO, which was obtained by the action of iodhydric acid on p‐chlorophenyl diazoacetophenon 14CO, resulting from the action of diazomethane on p‐chlorobenzoyl 14C chlorure. The necessary p‐chlorobenzoic carboxyl 14C acid was obtained through carbonatation of p‐chlorphenyl magnesium bromure, free from any isomere a or m. The total yield compared to 14CO3Ba was 31% Specific activity : 25, 3 mCi/mM.
Study on autoradiolysis of tritiated nucleosides
Authors: Kopoldova J. , Dedkova V. 
Published: October 2006

AbstractThe autoradiolytic decomposition of thymidine‐6‐T and uridine‐5‐T in aqueous solution at +2 and −15°C, in ethanol, and on chromatographic paper was studied in dependence on time of storage and specific activity.
A non‐exchange synthesis of tritium‐labelled tetrahydrocannabinols
Authors: Gill E. W. , Jones Gareth 
Published: October 2006

AbstractTritium‐labelled (‐) ‐Δ1 (6) and (‐) ‐Δ1 ‐tetrahy irocannabinols at a specific activity of 607 mCi/mmole were synthesized by a non‐exchange method. The tritium was introduced by the catalytic reduction with tritium gas of an unsaturated precursor of dimethyl olivetol in hexafluorobenzene as a non‐exchanging solvent. Specifically labelled olivetol was subsequently used in the synthesis of (‐) ‐Δ1 ‐tetrahydrocannabinol by an established method. The radiochemical purity of the product was shown to be greater than 98% by TLC, GLC, liquid scintillation counting and bioassay.
Specific tritium labelling of α ‐(p‐methoxyphenyl)‐α'‐nitro‐4 [3‐(dimethylamino) propoxy] stilbene (CI‐680) by catalytic deiodination
Authors: Blackburn C. E. 
Published: October 2006

AbstractIn an unusual example of tritium‐labelling by catalytic dehalogenation in the presence of competing groups, an iodinated precursor was selectively deiodinated with tritium gas to yield α‐(4‐methoxyphenyl‐3‐3H) ‐α'‐nitro‐4[3‐ (dimethylamino) propoxy] stilbene (CI‐680‐3H).The product was labelled specifically at the C‐3 position of the methoxyphenyl moiety with a specific radioactivity of 27.7 Ci/mmole and a net yield of 609 mCi. Characterization of CI‐680‐3H (base) established the chemical purity to be ≥99% and the radiochemical purity to be ≥97.6%. Characterization also included an evaluation of the tritium label stability in water and in aqueous acidic and basic media.
Preparation of some mercuri‐derivatives of iodinated fluorescein labelled with iodine‐131 I
Authors: Kronrád L. , Hladík V. 
Published: October 2006

AbstractMercurisation reaction of the iodinated fluorescein‐131I has been studied. Individual products formed in the reaction mixture were isolated with both paper chromatography and chromatography on alumina column. It was found that in contrast to unsubstituted fluorescein the yield of mercuriderivatives is considerably lower in case of iodinated fluorescein‐131I.
Syntheses de sept pyrimidines deuteriees en position specifique
Authors: Hervieu Jacqueline , Lautie‐Mouneyrac Marie‐France , Dagaut Jacques , Dizabo Pierre , Leitch Leonard C. , N‐Renaud Roger 
Published: October 2006

AbstractThe synthesis of seven deuteriopyrimidines of high isotopic purity was effected either by reductive dechlorination of chloropyrimidines with deuterium on a Pd/CaCO3 catalyst, deuterolysis of sulfonylhydrazinopyrimidines with mild base in D2 O or oxidation of hydrazinopyrimidines with silver acetate.
Contribution a l'etude des echanges isotopiques du tritium dans le phenol a haute temperature
Authors: Bettens B. , Dubois E. 
Published: October 2006

AbstractThe experimental determination of the exchange rate, first between the tritium fixed on the OH function and the hydrogen of the nucleus, and then between the tritium specifically fixed on the cycle and the OH function has been studied.The experimental results are obtained by two different ways, the lyophilisation and the transformation in the corresponding phenolate.By means of the experimental values we have calculated the activation energy of the exchange. With these values, it is possible to show that : a) due to its stability, the molecule can be use as tracer at high temperature in gazeous phase. b) the compounds with labile hydrogene have a certain catalytic effect on the isotopic exchange.
Synthesis of 1 ‐ deuterioaldehydes from methylene ‐ BIS ‐ pyridinium cations
Authors: Olofson R. A. , Zimmerman D. M. , Schnur Rodney C. 
Published: October 2006

AbstractA synthesis of 1‐deuterio and 1‐tritioaldehydes, especially arylaldehydes, from precursor gem‐dihalides is described. The scheme is especially useful when high label incorporation is desired.
Markierte verbindungen XIII. Hexachlor‐ 1.3 ‐ cyclopentadien ‐ (36CL)
Authors: Boberg Friedrich , Khalaf Hosni 
Published: October 2006

AbstractThe exchange of chlorine between hexachloro‐1.3‐ cyclopentadiene and AlCl3‐ (36 Cl) is studied. Chlorocyclo‐C3 ‐compounds ‐( 36 Cl) are synthesized.
Synthesis of picolinic‐(carboxyl‐14C) acid and 2‐{(methylsulfinyl) acetyl ‐ (carbonyl ‐14C)} pyridine
Authors: Merril E. J. , Vernice G. G. 
Published: October 2006

AbstractPicolinic‐ (carboxyl‐14C) acid was prepared by carbonation of the lithio derivative obtatined from n‐butyl lithium and 2‐bromopyridine. This was esterified and allowed to react with the anion generated from dimethyl sulfoxide by sodium hydride to give 2‐[(methylsulfinyl)acetyl‐(carbonyl‐14C)] pyridine.
Preparation of [14C] triethylaluminium
Authors: Ayrey G. , Mazza R. J. 
Published: October 2006

AbstractA method for the preparation of [14C] triethylaluminium by catalysed exchange of [14C] ethylene with inactive triethylaluminium is described. Novel methods for handling this spontaneously inflammable substance were developed and used for hydrolytic and radiochemical analyses.
Labelled polypeptides, III. Synthesis of α‐melanotropin labelled with tritium on the tyrosine residue
Authors: Medzihradszky K. , Nikolics K. , Teplan I. , Seprodi J. , Fittkau S. 
Published: October 2006

AbstractThe synthesis and purification of α‐melanotropin labelled with tritium on the tyrosine residue is described. The hormone possesses a specific radioactivity of 2.8 Ci/mmole, which enables its application in studying transport processes, metabolism and mechanism of hormone action.