bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review
Authors: Soltani Sepideh , Garousi Maryam , Mirzaee Elahe , Koolaji Sogol , Nazari Hengameh , Emami Sepideh , Zare Mehrjardi Ali , Arefpour Amir Mohammad 
Published: April 2024

AbstractBackgroundPrimary cardiac myxofibrosarcoma is a rare and aggressive malignancy, with the majority of approaching strategies relying on case reports. This article provides insights into its diagnosis and treatment.Case PresentationThis paper presents the case of a 40‐year‐old man with sudden onset hemoptysis, leading to the diagnosis of primary cardiac myxofibrosarcoma. Treatment involved open‐heart surgery to excise the left atrium tumor, followed by 6 cycles of adjuvant chemotherapy. Unfortunately, brain metastasis developed, leading to the patient's death 1 year after initial diagnosis.ConclusionPrimary cardiac myxofibrosarcoma remains a clinical challenge with an unfavorable prognosis. Early diagnosis through advanced imaging is crucial, and research is needed to explore innovative treatments. This case underscores the complexities of managing this rare cardiac malignancy and highlights the necessity for ongoing investigations to enhance patient outcomes.
Informed Consent for Psychotherapy: The Moderating Role of Therapeutic Alliance, Prior Knowledge and Autonomous Motivation on Decision‐Making and Treatment Expectation
Authors: Ladwig Sönke , Pauls Franz , Gerke Leonie , Nestoriuc Yvonne 
Published: April 2024

ABSTRACTBackgroundInformed consent is an ethical prerequisite for psychotherapy. There are no routinely used standardized strategies for obtaining informed consent. A new optimized informed consent consultation (OIC) strengthened treatment‐relevant aspects. It remains unclear which factors influence the OIC efficacy regarding clinical and decision‐related outcomes.MethodsN = 122 adults were included in a randomized controlled online trial. Participants received an information brochure on psychotherapy (TAU; n = 61) or OIC + TAU (n = 61). The main and interaction effects of group allocation, therapeutic alliance, prior knowledge about psychotherapy and treatment motivation on treatment expectations, decisional conflict and capacity to consent were tested. Floodlight analyses were conducted for significant interactions.ResultsLarge interaction effects were shown between treatment motivation and group allocation on treatment expectations (β = −0.53) and between prior knowledge and group assignment on capacity to consent (β = 0.68). The interaction between treatment motivation and group allocation was significant up to a motivation score of 5.54 (range: 1–7). The interaction between prior knowledge and group assignment was significant up to a knowledge score of 14.38 (range: 5–20).ConclusionModerator analyses indicated varying efficacy degrees for the OIC regarding decisional outcomes and expectation. Especially patients with little treatment motivation or low prior knowledge benefited from optimized information about the efficacy and possible side effects of psychotherapy.Trial Registration: PsychArchives (https://doi.org/10.23668/psycharchives.4929): 17.06.2021
Use of current automatic smoke evacuation system in flexible gastrointestinal endoscopy: Its feasibility and potential usefulness
Authors: Nose Yohei , Kato Motohiko , Aoyagi Shoma , Akeo Kazunori , Yamashita Kotaro , Saito Takuro , Tanaka Koji , Yamamoto Kazuyoshi , Makino Tomoki , Takahashi Tsuyoshi , Kurokawa Yukinori , Eguchi Hidetoshi , Doki Yuichiro , Nakajima Kiyokazu 
Published: April 2024

AbstractObjectivesFlexible endoscopy does not have a system that can automatically evacuate surgical smoke generated in the gastrointestinal lumen. We aimed to investigate the feasibility and potential usefulness of automatic smoke evacuation systems in flexible endoscopy.Methods[Bench] After surgical smoke generated in the stomach was evacuated by the evacuator, the degree of residual smoke and gastric luminal collapse were evaluated to optimize the evacuator settings. [Animal] Insufflation, suction, and total operation time to complete the protocol of 10 cauterizations of the gastric mucosa were measured in three groups: “manual suction only,” “manual suction with automatic evacuation (50% force),” and “manual suction with automatic evacuation (70% force).” The stability of endoscopic visualization and operability was evaluated by 10 endoscopists blinded to those suction settings, and the number of manual suctions, insufflations, and total operation time were measured.Results[Bench] The degree of residual smoke and gastric luminal collapse were inversely correlated. [Animal] When the automatic evacuator was partially used, there was no difference in the insufflation time, but the suction time (vs 50%; p = 0.011, vs. 70%; p = 0.011) and total operation time (vs. 50%; p = 0.012, vs. 70%; p = 0.036) were significantly reduced compared to manual operation only. Furthermore, manual suction with automatic evacuation (50% force) significantly improved the stability of endoscopic visualization and operability compared to manual operation only (p = 0.041, p = 0.0085).ConclusionsThe automatic smoke evacuation in flexible gastrointestinal endoscopy was potentially feasible and useful by improving the device setting.
Quantitative determination of R/S‐methadone in human serum using ultra‐high performance supercritical fluid chromatography‐tandem mass spectrometry: A method for routine use
Authors: Hansen Miriam , Havnen Hilde , Andreassen Trine Naalsund , Spigset Olav , Hegstad Solfrid 
Published: April 2024

AbstractMethadone has two enantiomers, which exhibit differences in pharmacological effects, with R‐methadone being the active and S‐methadone the inactive enantiomer. A robust, simple and rapid method for chiral separation of the two enantiomers in serum samples using ultra‐high performance supercritical fluid chromatography‐tandem mass spectrometry (UHPSFC‐MSMS) has been developed and validated. Enantiomeric separation was achieved using a Chiralpak IH‐3 column with a mobile phase consisting of CO2 and 30mM ammonium acetate in methanol/water (98/2, v/v). Runtime was 4 minutes. Sample preparation was semi‐automated using a Hamilton ML Star robot with protein precipitation, and phospholipid removal was carried out using a Waters OSTRO™ 96‐well plate. The calibration range was 50.0–1,500 nM for each enantiomer. The between‐assay relative standard deviations were in the range of 1.2–3.6%. Matrix effects ranged from 99% to 115% corrected with internal standard. The method has been implemented in our laboratory and has proven to be a robust and reliable method for determining the ratio of R/S‐methadone in authentic patient samples.
In vivo effects of cell seeding technique in an ex vivo regional gene therapy model for bone regeneration
Authors: Bell Jennifer A. , Mayfield Cory K. , Collon Kevin , Chang Stephanie , Gallo Matthew C. , Lechtholz‐Zey Elizabeth , Ayad Mina , Sugiyam Osamu , Tang Amy H. , Park Sang‐Hyun , Lieberman Jay R. 
Published: April 2024

AbstractWhen delivering cells on a scaffold to treat a bone defect, the cell seeding technique determines the number and distribution of cells within a scaffold, however the optimal technique has not been established. This study investigated if human adipose‐derived stem cells (ASCs) transduced with a lentiviral vector to overexpress bone morphogenetic protein 2 (BMP‐2) and loaded on a scaffold using dynamic orbital shaker could reduce the total cell dose required to heal a critical sized bone defect when compared with static seeding. Human ASCs were loaded onto a collagen/biphasic ceramic scaffold using static loading and dynamic orbital shaker techniques, compared with our labs standard loading technique, and implanted into femoral defects of nude rats. Both a low dose and standard dose of transduced cells were evaluated. Outcomes investigated included BMP‐2 production, radiographic healing, micro‐computerized tomography, histologic assessment, and biomechanical torsional testing. BMP‐2 production was higher in the orbital shaker cohort compared with the static seeding cohort. No statistically significant differences were noted in radiographic, histomorphometric, and biomechanical outcomes between the low‐dose static and dynamic seeding groups, however the standard‐dose static seeding cohort had superior biomechanical properties. The standard‐dose 5 million cell dose standard loading cohort had superior maximum torque and torsional stiffness on biomechanical testing. The use of orbital shaker technique was labor intensive and did not provide equivalent biomechanical results with the use of fewer cells.
Assessing the association between safety perceptions and communication about sex and drugs among Black adolescents exposed to adversity
Authors: Smith Bianca D. , Spencer Bailey Holmes , Nur‐Singletary Zakiyyah , Adane Nancy , Moser Naya , Powell Terrinieka W. 
Published: April 2024

AbstractThe present study examined the association between safety perceptions and communication with a trusted adult about sex and drugs among Black adolescents exposed to adverse childhood experiences (ACEs) and the role of gender as a potential moderator in this association. Data were drawn from a small, randomized control pilot test of an adapted evidence‐based intervention conducted from 2022 to 2023 in Baltimore, Maryland. The sample included 57 Black adolescents who had been exposed to ACEs (Mage = 15.14 years, SD = 0.81l; 47.4% female, 52.6% male). Information about safety perceptions, health communication, health behaviors, and demographic characteristics was measured using an electronic survey at baseline. Group differences by gender emerged among ACEs and substance use behaviors. Safety perceptions were significantly associated with communication with a trusted adult, B = 0.31, SE = 0.24, p = .039. As youth felt more unsafe, their communication with a trusted adult about sex and drugs increased; this association did not differ by gender. Health communication was also associated with ACEs. Black adolescents living with a parent with mental health challenges reported increased communication, B = 0.60, SE = 0.20, p = .005, whereas youth experiencing homelessness had reduced health communication, B = ‐0.63, SE = 0.24, p = .012. A lack of perceived safety significantly impacts health communication; however, having trusted adults outside of the home, school, and neighborhood can serve as a protective factor in reducing substance use and sexual risk‐taking among this population.
Responses of nesting greater white‐fronted geese to oil development in the Arctic
Authors: Rozell Kristen B. , Johnson Charles B. , Prichard Alexander K. , Gall Adrian E. , McGuire Rebecca L. 
Published: April 2024

AbstractOil and gas exploration and development is expanding across the Arctic Coastal Plain (ACP) of Alaska, USA. To examine the effects of industrial development on greater white‐fronted geese (Anser albifrons), we monitored nests and nesting behavior within a 4‐km2 study area within 4 km of gravel roads and pads during pre‐development, construction, and operation activities at a new oil development in the National Petroleum Reserve‐Alaska in 2013−2019. We examined distribution, incubation constancy, and nest survival in relation to distance to gravel roads or pads, year and status of development, presence of an ice road the previous winter, and land cover type. Nest density increased throughout the study period, which was consistent with surveys of this species in other regions of the ACP. There was no direct evidence that oil extraction infrastructure and the associated human activity adversely influenced the abundance, distribution, or daily nest survival of greater white‐fronted goose nests. Geese avoided nesting in the alignments of ice roads from the previous winter, and land cover type influenced their nest distribution. Nest age and incubation constancy were important predictors of daily nest survival. The incubation constancy of successful nesters (98.5 ± 0.1% [SE]) was significantly greater than for failed nesters (94.7 ± 0.6%) for all years combined and tended to be greater during the pre‐construction and construction years of 2014 and 2015, compared to when oilfield operations began in 2017 and 2019. Greater‐white fronted geese appear to be tolerant of some levels of industrial activities and the presence of gravel roads did not have a significant effect on nest distribution, incubation constancy, or nest survival. We recommend, however, that indirect effects from ice roads should be explicitly considered in impact assessments because white‐fronted geese avoid nesting in the footprints of the previous winter's ice roads and pads.
Evaluation of Pinto Genotypes of Common Bean for Resistance to Anthracnose
Authors: Mwense Brian P. , Hamabwe Swivia M. , Kuwabo Kuwabo , Mataa Mebelo , Miklas Phillip N. , Mukuma Chikoti , Kamfwa Kelvin 
Published: April 2024

ABSTRACTCommon bean (Phaseolus vulgaris L.) is an important crop grown for household revenue, food, and nutrition security in many parts of the world, especially in Africa and Latin America. Anthracnose caused by Colletotrichum lindemuthianum is a major disease of common bean globally. The objective of this study was to determine the response of selected pinto bean genotypes to seven races of C. lindemuthianum the causative fungus for anthracnose. A total of 56 pinto bean genotypes and three checks were evaluated for resistance to C. lindemuthianum races 51, 65, 73, 247, 253, 263, and 1085. Significant differences were observed among the 56 pinto genotypes in their reaction to the seven races, which was generally skewed towards susceptibility except for races 51 and 73. There was no genotype that was resistant to all seven races. In general, the genotypes that showed resistance to most of the races were those that carried Co‐42, which highlighted the importance of this locus to anthracnose resistance in pinto beans. Three genotypes—NDZ14006‐4, NDZ14110‐4, and NDZ14043—showed superior resistance (resistant to six of the seven races).
Polyphenol Extracts from Ziziphus jujuba Mill. “Junzao” Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice
Authors: Wei Xiaobo , Ma Ni , Yang Wen , Tian Jinhu , Liu Huiyan , Fang Haitian 
Published: April 2024

ScopePolyphenols are the major active substances in red jujube fruit, and their anti‐inflammatory and antioxidant activities suggest their potential utility in the prevention of ulcerative colitis (UC).Methods and resultsIn this study, the effect of polyphenol extracts from red jujube (Ziziphus jujuba Mill. “Junzao”) (PERJ) on the dextron sulfate sodium (DSS)‐induced UC mice is investigated. The result shows that PERJ effectively improves clinical symptoms, including food and water intake, the disease activity insex (DAI) and spleen index, and routine blood levels, and alleviates the shortening of the colon, in mice with DSS‐induced UC. Meanwhile, PERJ remarkably decreases the expression of proinflammatory factors. Moreover, PERJ repairs intestinal barrier damage by increasing the expression level of mucin 2 and mucin 3, and the result is also confirmed in the histological assessment. Besides, the expression levels of Nod‐like receptor family pyrin domain‐containing 3 (NLRP3) and mitogen‐activated protein kinase cascade (MAPKs) signaling pathway‐related proteins are inhibited by the PERJ administration. Finally, 16S rRNA sequencing analyses reveal that PERJ reverses intestinal microbiota dysbiosis by enhancing the abundance of Firmicutes and decreasing that of Proteobacteria and Bacteroidetes.ConclusionPERJ probably inhibits the development of UC by suppressing the NLRP3 and MAPKs signaling pathways and regulating gut microbiota homeostasis, and can be considered as a potential resource for preventing UC.
Decreased oral function in Japanese inpatients with schizophrenia
Authors: Watanabe Yuichiro , Otake Masataka , Ono Shin , Ootake Masaya , Murakami Kazuhiro , Kumagai Koichiro , Matsuzawa Koji , Kasahara Hiroyuki , Hori Kazuhiro , Someya Toshiyuki 
Published: April 2024

AbstractAimOral function in patients with schizophrenia has not been well‐characterized. To address this, we performed a cross‐sectional study of oral function in Japanese inpatients with schizophrenia.MethodsWe measured oral function, including occlusal force, tongue–lip motor function, tongue pressure, and masticatory function in 130 Japanese inpatients with schizophrenia. We then compared the frequency of clinical signs of oral hypofunction among 63 non‐elderly and 67 elderly inpatients with schizophrenia, as well as data from 98 elderly control participants from a previous Japanese study.ResultsThe frequency of reduced occlusal force was significantly higher in the elderly inpatients (76.2%) than in the non‐elderly inpatients (43.9%) and elderly controls (43.9%). The frequency of decreased tongue–lip motor function in non‐elderly inpatients (96.8%) and elderly inpatients (97.0%) was significantly higher than that in elderly controls (56.1%). The frequency of decreased tongue pressure in non‐elderly inpatients (66.1%) and elderly inpatients (80.7%) was significantly higher than that in elderly controls (43.9%). Finally, the frequency of decreased masticatory function was highest in elderly inpatients (76.5%), followed by non‐elderly inpatients (54.8%) and elderly controls (15.3%).ConclusionOral function was decreased in both non‐elderly and elderly Japanese inpatients with schizophrenia compared with elderly controls.
Do government performance signals affect citizen satisfaction?
Authors: Wang Weijie , Kim Taek Kyu 
Published: April 2024

AbstractPrevious studies have confirmed the causal effect of performance information on citizen satisfaction, but they were primarily conducted in survey experimental settings that featured hypothetical and abstract scenarios and primed respondents to look at certain aspects of performance information. Whether the causal effects hold in the real world, which is a much more complex information environment, is questionable. We address the gaps by employing a regression discontinuity design to identify the impact of public schools’ performance grades on parents’ satisfaction with teachers and overall education in New York City. We find that performance signals have independent and lasting effects on citizens’ satisfaction. However, the effects are nonlinear, depending on the levels of performance signals. Parents’ responses are muted at the A/B performance grade cutoff, but their satisfaction increases significantly at the B/C and C/D cutoffs if their schools earn relatively higher grades.
Biosensing with Oleosin‐Stabilized Liquid Crystal Droplets
Authors: Honaker Lawrence W. , Eijffius Axel , Plankensteiner Lorenz , Nikiforidis Constantinos V. , Deshpande Siddharth 
Published: April 2024

AbstractLiquid crystals (LCs) are emerging as novel platforms for chemical, physical, and biological sensing. They can be used to detect biological amphiphiles such as lipids, fatty acids, digestive surfactants, and bacterial endotoxins. However, designing LC‐based sensors in a manner that preserves their sensitivity and responsiveness to these stimuli, and possibly improves biocompatibility, remains challenging. In this work, the stabilization of LC droplets by oleosins, plant‐sourced and highly surface active proteins due to their extended amphipathic helix, is investigated. Purified oleosins, at sub‐micromolar concentrations, are shown to readily stabilize nematic LC droplets without switching their alignment, allowing them to detect surfactants at micromolar concentrations. Direct evidence of localization of oleosins at the LC–water interface is provided with fluorescent labeling, and the stabilized droplets remain stable over months. Interestingly, chiral LC droplets readily switch in the presence of nanomolar oleosin concentrations, an unexpected behavior that is explained by accounting for the energy barriers required for switching the alignment between the two cases. This leads thus to a twofold conclusion: oleosin‐stabilized nematic LC droplets present a biocompatible alternative for bioanalyte detection, while chiral LCs can be further investigated for use as highly sensitive sensors for detecting amphipathic helices in biological systems.
Construction of Hierarchical Conductive Networks for LiNi0.8Mn0.1Co0.1O2 Cathode toward Stable Cycling at High Areal Mass Loadings
Authors: Wei Lu , Wu Hongyuan , Liu Songtao , Zhou Yuyu , Guo Xin 
Published: April 2024

AbstractRealizing high‐performance thick electrodes is considered as a practical strategy to promote the energy density of lithium‐ion batteries. However, establishing effective transport pathways for both lithium‐ions and electrons in a thick electrode is very challenging. This study develops a hierarchical conductive network structure for constructing high‐performance NMC811 (LiNi0.8Mn0.1Co0.1O2) cathode toward stable cycling at high areal mass loadings. The hierarchical conductive networks are composed of a Li+/e− mixed conducting interface (lithium polyacrylate/hydroxyl‐functionalized multiwalled carbon nanotubes) on NMC811 particles, and a segregated network of single‐walled carbon nanotubes in the electrode, without any additional binders or carbon black. Such strategy endows the NMC811 cathode (up to 250 µm and 50 mg cm−2) with low porosity/tortuosity, ultrahigh Li+/e‐ conductivities and excellent mechanical property at low carbon nanotube content (1.8 wt%). It significantly improves the electrochemical reaction homogeneity along the electrode depth, meanwhile effectively inhibits the side reactions at the electrode/electrolyte interface and cracks in the NMC particles during cycling. This work emphasizes the crucial role of the electronic/ionic cooperative transportation in the performance deterioration of thick cathodes, and provide guidance for architecture optimization and performance improvement of thick electrodes toward practical applications, not just for the NMC811 cathode.
Decreased Electrically and Increased Ionically Conducting Scaffolds for Long‐Life, High‐Rate and Deep‐Capacity Lithium‐Metal Anodes
Authors: Li Chuanfa , Wang Jiaqi , Ye Qian , Li Pengzhou , Zhang Kun , Li Jiaxin , Zhang Yanan , Ye Lei , Song Tianbing , Gao Yue , Wang Bingjie , Peng Huisheng 
Published: April 2024

AbstractLithium (Li) metal batteries are deemed as promising next‐generation power solutions but are hindered by the uncontrolled dendrite growth and infinite volume change of Li anodes. The extensively studied 3D scaffolds as solutions generally lead to undesired “top‐growth” of Li due to their high electrical conductivity and the lack of ion‐transporting pathways. Here, by reducing electrical conductivity and increasing the ionic conductivity of the scaffold, the deposition spot of Li to the bottom of the scaffold can be regulated, thus resulting in a safe bottom‐up plating mode of the Li and dendrite‐free Li deposition. The resulting symmetrical cells with these scaffolds, despite with a limited pre‐plated Li capacity of 5 mAh cm−2, exhibit ultra‐stable Li plating/stripping for over 1 year (11 000 h) at a high current density of 3 mA cm−2 and a high areal capacity of 3 mAh cm−2. Moreover, the full cells with these scaffolds further demonstrate high cycling stability under challenging conditions, including high cathode loading of 21.6 mg cm−2, low negative‐to‐positive ratio of 1.6, and limited electrolyte‐to‐capacity ratio of 4.2 g Ah−1.