bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line
Authors: Wang Lumei , Zhou Shanshan , Lin Kunde , Zhao Meirong , Liug Weiping , Gan Jianying 
Published: August 2008

Abstract
Research increasingly suggests that selectivity between enantiomers may exist in acute and chronic toxicological effects of chiral contaminants. In this study, we used the human breast carcinoma MCF-7 cell line to evaluate enantioselectivity of o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT). Baseline separation of o,p'-DDT enantiomers was achieved on the Chiralcel® OJ chiral column by high-performance liquid chromatography, and the absolute configuration and optical rotation of the resolved enantiomers were further identified. Significant differences in estrogenic potential were observed between the two enantiomers of o,p'-DDT in the MCF-7 cell proliferation assay (i.e., the E-Screen assay) and the real-time quantitative polymerase chain reaction (PCR). In the E-Screen assay, the relative proliferative effect ratios of R-(—)-o,p'-DDT and S-(+)-o,p'-DDT were 89.4 and 27.9%, respectively, and the relative proliferative potency ratios were 0.1 and 0.001%, respectively. Compared to the solvent control, R-(—)-o,p'-DDT induced the maximal increase of 2.31-fold at a concentration of 10−6 mol/L, while S-(+)-o,p'-DDT at 10−5 mol/L induced the maximal increase of 1.65-fold in estrogenic biomarker pS2 mRNA level. The maximal down-regulation of the transcription levels of estrogen receptor a (ERα) and ERβ by R-(—)-o,p'-DDT were 49 and 40% at the concentration of 10−6 mol/L, while those by S-(+)-o,p'-DDT were 24 and 26% at the concentration of 10−5 mol/L. The cell proliferation, the up-regulation of pS2, and the down-regulation of ERα and ERβ gene expressions induced by the racemate and enantiomers of o,p'-DDT were all reversed by cotreatment with 10−6 mol/L ICI 182,780. Therefore, the enantioselective estrogenicity of o,p'-DDT was likely through the ERα and ERβ signaling pathways. Results from this study suggest the need for considering enantioselectivity of chiral contaminants in chronic ecological toxicities.
Short Radius Horizontal and Multilateral Re-entry of Oil and Water Injection Wells
Authors: Al-Ghamdi I. A. , Al-Hendi A. A. , Esmail O. J. 
Published: August 2008

Abstract
During the past four years Saudi Aramco has used short radius horizontal and multilateral drilling technology to increase oil recovery, productivity and injectivity of existing production and injection wells. This was achieved by (a) sidetracking oil wells with thin bypassed oil column and drilling short radius horizontal holes at the top of the reservoir to control water coning and increase oil recovery, (b) drilling short radius horizontal holes across thin reservoirs and increase the wellbore flow area and well productivity, and (c) drilling multilateral short radius horizontal holes to increase the productivity and injectivity of existing oil and water injection wells completed in low permeability reservoirs. This paper presents well case histories that describe the drilling and completion operations and compare the performances of the horizontal and conventional wells.
Helmholtz Plane Reconfiguration Enables Robust Zinc Metal Anode in Aqueous Zinc‐Ion Batteries
Authors: Wu Tingqing , Hu Chao , Zhang Qi , Yang Zefang , Jin Guanhua , Li Yixin , Tang Yougen , Li Huanhuan , Wang Haiyan 
Published: April 2024

AbstractAqueous zinc‐ion batteries are promising for next‐generation energy storage systems. However, the zinc dendrite growth, corrosion, and hydrogen evolution reaction at the electrochemical interface severely impede their further development. Herein, a Zn2+‐rich and H2O‐poor Helmholtz plane is constructed to regulate the electrochemical interface between the zinc anode and the electrolyte. Electrochemical and in situ spectroscopy characterizations reveal that the designed electric double layer with abundant Zn2+ coordination sites and less H2O content can facilitate rapid electron transfer, homogenize Zn2+ deposition, and alleviate the side reactions induced by active H2O. Benefiting from the high reversibility and stability of zinc anode, the Zn||Zn symmetric cell can be cycled over 1000 h at 1 mA cm−2 and the Zn||NH4V4O10 full cell can maintain a capacity of 85.23% for 1000 cycles at 3 A g−1. This work aims at Helmholtz plane reconfiguration and provides a realizable strategy in interface construction for other similar systems.
Cellulosic Nonwovens Incorporated with Fully Utilized MXene Precursor as Smart Pressure Sensor and Multi‐Protection Materials
Authors: Yu Zhaochuan , Deng Chao , Sun Jianglei , Zhang Xing , Liu Yuqian , Liu Chao , Seidi Farzad , Han Jingquan , Yong Qiang , Xiao Huining 
Published: April 2024

AbstractCurrently, multifunctional MXene‐integrated wearable textiles (MWTs) are particularly appealing due to their various applications such as health monitoring, smart protection, and medical treatment. However, scalable manufacture of durable, stable, and high‐performance multifunctional MWTs still face challenges due to the poor oxidation stability of MXene and low utilization of precursor titanium aluminum carbide (MAX). Herein, an improved preparation strategy for zinc ion (Zn2+) intercalation is proposed to create high antioxidative MXene (ZM) and exceptionally conductive and printable gel ink based on MXene sediments (ZMS‐ink), while multifunctional wearable textiles are fabricated using spray‐coating and screen‐printing techniques on cellulosic nonwoven textiles (CNWs), achieving the complete utilization of MXene precursor. Benefiting from the inherent disordered stacking and porous structure of CNWs, along with the highly conductive ZM and ZMS‐ink, as‐prepared smart, wearable and green‐based pressure sensor offered proper breathability, high sensitivity (2602.26 kPa−1), wide sensing range (0–141 kPa), and excellent cycling stability (>5000 cycles). Additionally, the sensor exhibited efficient photothermal/photodynamic therapy antibacterial activity and exceptional electromagnetic interference shielding performance (57.5 dB). Therefore, this work paves the way for the future development of integrated and scalable multifunctional wearable devices building on the environmental‐friendly CNWs incorporated with fully utilized MAX, offering a green and cost‐effective approach.
Gold‐Template‐Assisted Mechanical Exfoliation of Large‐Area 2D Layers Enables Efficient and Precise Construction of Moiré Superlattices
Authors: Wu Kang , Wang Hao , Yang Meng , Liu Li , Sun Zhenyu , Hu Guojing , Song Yanpeng , Han Xin , Guo Jiangang , Wu Kehui , Feng Baojie , Shen Chengmin , Huang Yuan , Shi Youguo , Cheng Zhigang , Yang Haitao , Bao Lihong , Pantelides Sokrates T. , Gao Hong‐Jun 
Published: April 2024

AbstractMoiré superlattices, consisting of rotationally aligned 2D atomically thin layers, provide a highly novel platform for the study of correlated quantum phenomena. However, reliable and efficient construction of moiré superlattices is challenging because of difficulties to accurately angle‐align small exfoliated 2D layers and the need to shun wet‐transfer processes. Here, efficient and precise construction of various moiré superlattices is demonstrated by picking up and stacking large‐area 2D mono‐ or few‐layer crystals with predetermined crystal axes, made possible by a gold‐template‐assisted mechanical exfoliation method. The exfoliated 2D layers are semiconductors, superconductors, or magnets and their high quality is confirmed by photoluminescence and Raman spectra and by electrical transport measurements of fabricated field‐effect transistors and Hall devices. Twisted homobilayers with angle‐twisting accuracy of ≈0.3°, twisted heterobilayers with sub‐degree angle‐alignment accuracy, and multilayer superlattices are precisely constructed and characterized by their moiré patterns, interlayer excitons, and second harmonic generation. The present study paves the way for exploring emergent phenomena in moiré superlattices.
Supergravity‐Steered Generic Manufacturing of Nanosheets‐Embedded Nanocomposite Hydrogel with Highly Oriented, Heterogeneous Architecture
Authors: Xu Guang‐Chang , Nie Yihan , Li Hao‐Nan , Li Wan‐Long , Lin Wan‐Ting , Xue Yu‐Ren , Li Kai , Fang Yu , Liang Hong‐Qing , Yang Hao‐Cheng , Zhan Haifei , Zhang Chao , Lü Chaofeng , Xu Zhi‐Kang 
Published: April 2024

AbstractDesigning nanocomposite hydrogels with oriented nanosheets has emerged as a promising toolkit to achieve preferential performances that go beyond their disordered counterparts. Although current fabrication strategies via electric/magnetic force fields have made remarkable achievements, they necessitate special properties of nanosheets and suffer from an inferior orientation degree of nanosheets. Herein, a facile and universal approach is discovered to elaborate MXene‐based nanocomposite hydrogels with highly oriented, heterogeneous architecture by virtue of supergravity to replace conventional force fields. The key to such architecture is to leverage bidirectional, force‐tunable attributes of supergravity containing coupled orthogonal shear and centrifugal force field for steering high‐efficient movement, pre‐orientation, and stacking of MXene nanosheets in the bottom. Such a synergetic effect allows for yielding heterogeneous nanocomposite hydrogels with a high‐orientation MXene‐rich layer (orientation degree, f = 0.83) and a polymer‐rich layer. The authors demonstrate that MXene‐based nanocomposite hydrogels leverage their high‐orientation, heterogeneous architecture to deliver an extraordinary electromagnetic interference shielding effectiveness of 55.2 dB at 12.4 GHz yet using a super‐low MXene of 0.3 wt%, surpassing most hydrogels‐based electromagnetic shielding materials. This versatile supergravity‐steered strategy can be further extended to arbitrary nanosheets including MoS2, GO, and C3N4, offering a paradigm in the development of oriented nanocomposites.
n‐Bu4NI/K2S2O8 Mediated Csp2−Csp2 Bond Cleavage – Transformylation from p‐Anisaldehyde to Primary Amides
Authors: Liu Xiaochen , Hee Samual , Sapir Netanel G. , Li Alvin , Liu Jianbo , Chen Yu 
Published: April 2024

Abstractn‐Bu4NI/K2S2O8 mediated transformylation from p‐anisaldehyde to primary amides is reported. The mechanistic studies suggest the reaction occurs via a single electron transfer pathway. Based on the DFT electronic structure calculations of various reaction pathways, the most plausible mechanism involves the formation of a phenyl radical cation and an arenium ion as the key intermediates. It represents the first example where p‐anisaldehyde is employed as a formyl source via a non‐metal mediated Csp2−Csp2 bond cleavage.
Solid‐Phase Synthesis of Peptidols via Reductive Cleavage Through a Benzotriazole Linker
Authors: Chen Szu‐Hsuan , Chuang Hui‐Ying , Rajavel Chitra , Kai Lin Yi , Chang Shu‐Han , Tsai Pei‐Chen , Chen Hui‐Ting , Sun Chung‐Ming , Selvaraj Anand , Kao Chai‐Lin 
Published: April 2024

AbstractPeptidols were prepared through the reductive cleavage of benzotriazole intermediates obtained from the on‐bead activation of 3,4‐diaminobenzoyl linkers. Remarkably, this method used commercially available amino acid residues and resins without further modification. Pure peptidols were collected with only filtration in 49%–87% yield. Only the derivatives with aspartic acid as the first C‐terminal residue required sophisticated chromatography purification. Esters and carboxylic acids were identified as side products and were suppressed by additional reduction or reduction in DMF. Remarkably, the reduction of peptides with the first aspartic acid residue at the C‐terminal afforded a C‐terminal lactone, which could be reduced by deprotection at 0 °C. For the synthesis of branched peptidols, the bulky wedge structures of the branched peptides resulted in low total yields, which were improved to 23%–28% by using peripheral Boc groups and SPPS on the Tental gel resin. In addition, this method gave two peptaibols, SPF‐5506‐A4 and Ac‐Gramicidin A, in 11% and 46% yields, respectively.
Chloro‐Functionalized Ether‐Based Electrolyte for High‐Voltage and Stable Potassium‐Ion Batteries
Authors: Hu Yanyao , Fu Hongwei , Geng Yuanhui , Yang Xiaoteng , Fan Ling , Zhou Jiang , Lu Bingan 
Published: April 2024

AbstractEther‐based electrolyte is beneficial to obtaining good low‐temperature performance and high ionic conductivity in potassium ion batteries. However, the dilute ether‐based electrolytes usually result in ion‐solvent co‐intercalation of graphite, poor cycling stability, and hard to withstand high voltage cathodes above 4.0 V. To address the aforementioned issues, an electron‐withdrawing group (chloro‐substitution) was introduced to regulate the solid‐electrolyte interphase (SEI) and enhance the oxidative stability of ether‐based electrolytes. The dilute (~0.91 M) chloro‐functionalized ether‐based electrolyte not only facilitates the formation of homogeneous dual halides‐based SEI, but also effectively suppress aluminum corrosion at high voltage. Using this functionalized electrolyte, the K||graphite cell exhibits a stability of 700 cycles, the K||Prussian blue (PB) cell (4.3 V) delivers a stability of 500 cycles, and the PB||graphite full‐cell reveals a long stability of 6000 cycles with a high average Coulombic efficiency of 99.98 %. Additionally, the PB||graphite full‐cell can operate under a wide temperature range from −5 °C to 45 °C. This work highlights the positive impact of electrolyte functionalization on the electrochemical performance, providing a bright future of ether‐based electrolytes application for long‐lasting, wide‐temperature, and high Coulombic efficiency PIBs and beyond.
Highly Efficient One‐pot Electrosynthesis of Oxime Ethers from NOx over Ultrafine MgO Nanoparticles Derived from Mg‐based Metal‐Organic Frameworks
Authors: Wang Shihan , Xiang Runan , Liao Peisen , Kang Jiawei , Li Suisheng , Mao Min , Liu Lingmei , Li Guangqin 
Published: April 2024

AbstractOxime ethers are attractive compounds in medicinal scaffolds due to the biological and pharmaceutical properties, however, the crucial and widespread step of industrial oxime formation using explosive hydroxylamine (NH2OH) is insecure and troublesome. Herein, we present a convenient method of oxime ether synthesis in a one‐pot tandem electrochemical system using magnesium based metal‐organic framework‐derived magnesium oxide anchoring in self‐supporting carbon nanofiber membrane catalyst (MgO‐SCM), the in situ produced NH2OH from nitrogen oxides electrocatalytic reduction coupled with aldehyde to produce 4‐cyanobenzaldoxime with a selectivity of 93 % and Faraday efficiency up to 65.1 %, which further reacted with benzyl bromide to directly give oxime ether precipitate with a purity of 97 % by convenient filtering separation. The high efficiency was attributed to the ultrafine MgO nanoparticles in MgO‐SCM, effectively inhibiting hydrogen evolution reaction and accelerating the production of NH2OH, which rapidly attacked carbonyl of aldehydes to form oximes, but hardly crossed the hydrogenation barrier of forming amines, thus leading to a high yield of oxime ether when coupling benzyl bromide nucleophilic reaction. This work highlights the importance of kinetic control in complex electrosynthetic organonitrogen system and demonstrates a green and safe alternative method for synthesis of organic nitrogen drug molecules.
Boost the Circularly Polarized Phosphorescence of Chiral Organometallic Platinum Complexes by Hierarchical Assembly into Fibrillar Networks
Authors: Gong Zhong‐Liang , Dan Ti‐Xiong , Chen Jian‐Cheng , Li Zhong‐Qiu , Yao Jiannian , Zhong Yu‐Wu 
Published: April 2024

AbstractCircularly polarized luminescence (CPL)‐active molecular materials have drawn increasing attention due to their promising applications for next‐generation display and optoelectronic technologies. Currently, it is challenging to obtain CPL materials with both large luminescence dissymmetry factor (glum) and high quantum yield (Φ). A pair of enantiomeric N N C‐type Pt(II) complexes (L/D)‐1 modified with chiral Leucine methyl ester are presented herein. Though the solutions of these complexes are CPL‐inactive, the spin‐coated thin films of (L/D)‐1 exhibit giantly‐amplified circularly polarized phosphorescences with |glum| of 0.53 at 560 nm and Φair of ~50 %, as well as appealing circular dichroism (CD) signals with the maximum absorption dissymmetry factor |gabs| of 0.37–0.43 at 480 nm. This superior CPL performance benefits from the hierarchical formation of crystalline fibrillar networks upon spin coating. Comparative studies of another pair of chiral Pt(II) complexes (L/D)‐2 with a symmetric N C N coordination mode suggest that the asymmetric N N C coordination of (L/D)‐1 are favorable for the efficient exciton delocalization to amplify the CPL performance. Optical applications of the thin films of (L/D)‐1 in CPL‐contrast imaging and inducing CP light generation from achiral emitters and common light‐emitting diode lamps have been successfully realized.
A Nonlinear Photochromic Reaction Based on Sensitizer‐Free Triplet–Triplet Annihilation in a Perylene‐Substituted Rhodamine Spirolactam
Authors: Kawai Genki , Nagai Yuki , Tsuji Kanna , Okayasu Yoshinori , Abe Jiro , Kobayashi Yoichi 
Published: April 2024

AbstractNonlinear photochromic reactions that work with weak incoherent light are important for molecular operations with high spatial resolution and multiple photofunctions based on single molecules. However, nonlinear photochromic compounds generally require complex molecular design, restricting accessibility in various fields. Herein, we report nonlinear photochromic properties in a perylene‐substituted rhodamine spirolactam derivative (Rh−Pe), which is synthesized from rhodamine B in facile procedures. Direct excitation of Rh−Pe produces the triplet excited state via the charge‐transfer (CT) state. The triplet excited state causes triplet–triplet annihilation to bring the generation of the intensely colored ring‐open form with nonlinear behavior. Furthermore, green‐ and red‐light‐induced photochromism was achieved in Rh−Pe using triplet sensitizers, although Rh−Pe can be directly excited only by ultraviolet and blue light. Our findings are expected to contribute to the development of photofunctional materials showing nonlinear behavior and low‐energy light responsivity.
Cervical anatomy and its relation to foraging habits in aquatic birds (Aves: Neornithes: Neoaves)
Authors: Buchmann Richard , Rodrigues Taissa 
Published: April 2024

AbstractBirds have extremely flexible necks, which help in their search for food. However, studies on the variation in bird cervical anatomy and its relationship with foraging are rare, despite the different habits presented between species. Here, we analyze the anatomy of the neck of aquatic birds and relate it to their foraging strategies. We dissected specimens representing four species of Charadriiformes, 11 species of Phaethoquornithes, and two specimens belonging to the outgroup Telluraves. We chose to emphasize Charadriiformes and Phaethoquornithes because they present several strategies that require cervical mobility and stability. We note that vertebral anatomy and dimensions vary, which affects the shape and size of the soft tissues attached throughout the neck. The synovial cartilage present in the articulatio intercorporalis represents an additional length in the neck, however, this is not longer than that observed in animals with intervertebral discs. Our analysis indicates that birds have a prevalence of dorsoventral movements in the middle of the neck and lateral and rotational movements near the base of the neck, while the region near the head presents a wide range of movement in all directions. Cervical ligaments and muscles throughout the neck provide stability in all segments, although the robustness of the soft tissues indicates that the most caudal portion of the neck is the most stable. The vertebral and soft tissue anatomy is consistent with the extensive mobility in pitching, yaw, and roll movements performed mainly by the head and first segment of the neck during the different foraging of the analyzed birds. Furthermore, the muscles closer to the skull are robust and allow the execution of a variety of habits to capture food in different species. The subsequent cervical segments present differences that explain their reduction in mobility, but they are equally stable.
Real‐world patient characteristics, treatment patterns, and treatment outcomes of patients with diffuse large B‐cell lymphoma by line of therapy
Authors: Sineshaw Helmneh M. , Zettler Christina M. , Prescott Jennifer , Garg Mahek , Chakraborty Samhita , Sarpong Eric M. , Bai Claire , Belli Andrew J. , Fernandes Laura L. , Wang Ching‐Kun 
Published: April 2024

AbstractBackgroundAlthough initial treatment of diffuse large B‐cell lymphoma (DLBCL) with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) can be effective, up to 50% of patients will develop refractory or relapsed (R/R) disease. This study aimed to provide contemporary data on characteristics, treatment patterns, and outcomes for R/R‐DLBCL.MethodsPatients with incident (January 2016 to March 2021) DLBCL age ≥18 years who initiated first‐line (1L) therapy were identified from the COTA real‐world database. Baseline characteristics, treatment patterns, and real‐world outcomes, including time to next treatment (rwTTNT) and overall survival (rwOS), were assessed for the study population and by line of therapy (LOT).ResultsA total of 1347 eligible DLBCL patients were identified. Of these, 340 (25.2%) proceeded to receive 2L, of whom 141 (41.5%) proceeded to receive 3L, of whom 51 (36.2%) proceeded to receive 4L+. Most common treatments were R‐CHOP in 1L (63.6%), stem cell transplant (SCT) in 2L (17.9%), polatuzumab vedotin, bendamustine, and rituximab (Pola‐BR) in 3L (9.9%), and chimeric antigen receptor T‐cell therapy (CAR‐T) in 4L (11.8%). Treatment patterns were more variable in later LOTs. One‐ and 3‐year rwOS from 1L initiation were 88.5% and 78.4%, respectively. Patients who received later LOTs experienced numerically lower 1‐ and 3‐year rwOS (from 2L initiation: 62.4% and 46.4%, respectively).ConclusionsIn this real‐world analysis, 25.2% of patients experienced R/R‐DLBCL after 1L with poor outcomes. Given the findings of this study, there is a high unmet need for novel, safe, and effective treatment options for patients with R/R DLBCL.