bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy
Authors: Green Daniel M. , Samulski Thaddeus V. , Vervaert Carol , Halperin Edward C. , Oleson James R. , Seigler Hilliard 
Published: February 2007

AbstractRecent investigations suggest that adjuvant hyperthermia enhances the response of human malignant melanoma to ionizing radiation. A study was undertaken to explore the effect of radiation and hyperthermia on the responsiveness of melanoma following active immunization with lethally irradiated B16 melanoma cells in C57 BL 6 mice. Two groups of mice were treated: group 1 received immunotherapy on days 2–5 following tumor innoculation, and group 2 received immunotherapy on days 15–18 following tumor innoculation. The mice in each group were subsequently randomized into one of three subgroups: 1) no further treatment; 2) radiation therapy alone (6 Gy in a single fraction); 3) radiation therapy and regional hyperthermia (43°C × 1 hour). Tumor sizes were measured regularly, and between day 52 and 63 the animals were sacrificed and the lungs sectioned for counting of metastatic tumors. Results from this study show that the immunomodulated B16 murine melanoma is responsive to radiation therapy alone and that this responsiveness is enhanced by the addition of adjuvant regional hyperthermia. There did not appear to be any significant effect of radiation therapy or radiation therapy plus hyperthermia on the development of lung metastases in this tumor model system.
Pulmonary coin lesions caused by Dirofilaria immitis
Authors: Bailey Timothy S. , Sohrabi Abdolkarim , Roberts Andstuart S. 
Published: February 2007

AbstractThe dog heartworm Dirofilaria immitis has been diagnosed by thoracotomy as the etiology of neoplastic‐appearing nodules in two patients in the Peoria, Illinois area. This brings the total number of reported cases of human pulmonary dirofilariasis to approximately 81 in the United States. The major concern of this benign disease is that in making the diagnosis the patients undergo the risk of surgery because of the presumed preoperative diagnosis of cancer. Greater awareness of this disease is needed as the geographic distribution of human pulmonary dirofilariasis expands in this country.
Extrapericardial tamponade with herniated omentum after transhiatal esophagectomy
Authors: Granke Kenneth , Hoshal Verne L. , Vanden Belt Ron J. 
Published: February 2007

AbstractAn unusual complication following transhiatal esophagectomy for lower esophageal carcinoma is reported in which extrapericardial tamponade and profound shock occurred secondary to a herniated section of omentum in the immediate postoperative period. The two‐dimensional echocardiogram was nondiagnostic, but the diagnosis was confirmed during reex‐ploration of the abdomen. Anatomic and pathophysiologic considerations of this unusual but life‐threatening complication are discussed. The literature suggests that computed tomography is the study of choice to confirm the clinical diagnosis of pericardial pathology, and this case report is yet another example to support routine closure of the esophageal aperture.
Impact of screening mammography and change in surgeons' attitudes on the pattern of primary care of breast cancer at a community hospital
Authors: Goldsweig Howard G. , O'Sullivan Marjorie 
Published: February 2007

AbstractTo gauge the impact of screening mammography and opinions regarding surgical procedures on the pattern of primary surgical care of breast cancer, tumor registry statistics from 1980–81 were compared to those from 1987 at a large community hospital. Over the course of six years, there was a significant increase in the proportion of patients with smaller tumors. Breast‐conserving procedures increased from 8% to 39% of all therapeutic surgery. However, there was no change in the stage of the tumor at presentation because of an atypically low incidence of nodal involvement in 1980–81.
Feasibility and outcome of complete secondary tumor resection for patients with advanced ovarian cancer
Authors: Lawton Frank , Luesley David , Redman Charles , Chan K. K. , Varma Raiiv , Blackledge George 
Published: February 2007

AbstractFrom November 1981 to July 1985, 124 women with International Federation of Gynecology and Obstetrics (FIGO) stage III ovarian cancer were treated in prospective studies of surgery and chemotherapy in our institution. Patients with no macroscopic cancer after primary surgery (n = 16) received five cycles of adjuvant cis‐platinum; those with residual cancer after primary laparotomy (n = 108) underwent a second surgical debulking after three or five cycles of cis‐platinum‐based cytoreductive chemotherapy. Total macroscopic tumor clearance was achieved in 26 of these 108 patients. Fourteen patients with total tumor excision at primary laparotomy remain in complete clinical remission a minimum of 36 months after diagnosis, but the median progression‐free interval for the other two groups was 9 and 17 months, respectively. The survival for women who have total tumor clearance only at secondary surgery after chemotherapy is inferior to that for women with primary macroscopic tumor excision followed by chemotherapy.
Synovial sarcoma: A clinicopathological study of 36 cases
Authors: Golouh Rastko , Vuzevski Vojislav , Bracko Matej , Van Der Heul Roy Otto , Cervek Jozica 
Published: February 2007

AbstractThirty‐six cases of synovial sarcoma (13 biphasic and 23 monophasic) were subjected to a clinicopathologic study that included electron microscopy and immunohistochemistry. The group consisted of 21 males and 15 females ranging in age from 2 to 63 years. The majority of tumors (27 cases) were found in the hip and lower extremity. Immunohistochemical study revealed that keratin, which was detected in 92% of the biphasic and 57% of the monophasic tumors, was a more sensitive marker of epithelial differentiation than EMA or CEA. The overall 5‐year survival of the patients was 64%. Male sex, older age, presence of tumor necrosis, monophasic pattern, and absence of keratin positivity had an unfavourable effect on survival but lacked statistical significance. Survival was significantly lower in patients with tumors exhibiting more than 15 mitoses per 10 HPF (P < .02) and in those with tumors showing necrosis and a mitotic rate greater than 5 mitoses per 10 HPF (P < .005).
Adenocarcinoma of the esophagus: A survival study
Authors: Harvey James C. , Kagan A. Robert , Ahn Chaewoo , Frankl Harold , Davidson William 
Published: February 2007

AbstractA 35 year review of adenocarcinomas of the esophagus was undertaken. We found the disease to be one of increasing incidence afflicting white males disproportionately. Risk factors remain to be clarified. Radiation therapy in curative doses and complete resection were competitively effective in terms of long‐term survival. No survival advantage was found with palliative surgery compared with other means of therapy. Optimal combinations of treatment remain to be discovered.
Malignant pleural mesothelioma: A survival study
Authors: Harvey James C. , Fleischman Erik H. , Kagan A. Robert , Streeter Oscar E. 
Published: February 2007

AbstractNinety‐four patients with malignant pleural mesothelioma were treated at Southern California Permanente Medical Group Facilities between 1965 and 1988. This retrospective analysis of survival in these patients is compared according to surgical and/or supportive management. Group I patients received supportive care only, including pleurodesis as needed. This group included the majority of patients. Group II patients were managed largely with debulking procedures including decortication and pleurectomy. Group III patients received extrapleural pneumonectomy. This group included the two long‐term survivors of the entire group. This study of survival points out the need for a cooperative protocol as well as the consistent use of proper modern preoperative staging in an attempt to select patients who benefit from extrapleural pneumonectomy.
Treatment for synchronous and metachronous carcinomas of the head and neck and esophagus
Authors: Tachimori Yuji , Watanabe Hiroshi , Kato Hoichi , Ebihara Satoshi , Ono Isamu , Nakatsuka Takashi , Harii Kiyonori 
Published: February 2007

AbstractIn the past 27 years, 75 patients were found to have separate primary carcinomas of the head and neck and the esophagus. Head and neck tumor was discovered first in 41 patients, synchronously with esophageal tumors in 17 patients, and esophageal tumors were recognized first in 17 patients. Reconstruction by graft after resection of head and neck cancer was nec‐ essary in 18 patients and esophagectomy was performed in 62 patients. In eight patients, pharyngeal and esophageal reconstruction was necessary after resection of synchronous and metachronous pharyngeal and esophageal carcinoma. The combined procedure with free tissue transfer was useful for surgical treatment for synchronous or metachronous carcinomas of the head and neck and the esophagus.
Postoperative radiation therapy for major salivary gland malignancies
Authors: Harrison Louis B. , Armstrong John G. , Spiro Ronald H. , Fass Daniel E. , Strong Elliot W. 
Published: February 2007

AbstractBetween 1966 and 1982 there have been 46 patients treated with surgery plus post‐operative radiation therapy for malignant tumors of salivary gland origin. The indication(s) for radiotherapy included positive margins (42%), advanced local tumor (37%), positive nodes (33%), or high grade histology (48%). Overall actuarial local control at 5 years was 73%, being 100% for T1, 83% for T2, 80% for T3, and 43% for T4. Actuarial survival at 5 years was 80% for T1, 83% for T2 60% for T3 and 48% for T4. Patients with positive nodes (N+) did worse than those with negative nodes (No), with locoregional control and survival at 5 years being 58% vs. 83%, ( P=0.025) and 38% vs. 80% (P=<.01), respectively. We found no need for contralateral neck treatment even for those with positive nodes. Also, to date, none of eight patients with adenoid cystic histology has failed locally, as opposed to three of eight failures in patients treated with surgery alone. We believe that post‐operative irradiation provides excellent locoregional control for appropriate patients with malignant tumors of major salivary glands.
Umbilical metastasis diagnosed by fine needle aspiration
Authors: Edoute Yehouda , Malberger Ehud , Kuten Abraham 
Published: February 2007

AbstractFine needle aspiration (FNA) is emerging as a useful diagnostic tool in the evaluation of tumor masses, providing high diagnostic yield. Fine needle aspiration for cytologic evaluation was performed on 14 patients suspected of having umbilical metastasis. The site of the primary tumor was known in 12 patients. In nine patients with previously documented malignancy, FNA of the umbilical nodule demonstrated malignant cells compatible with the histologic diagnosis of the primary cancer. In five other patients metastatic umbilical nodule was the first or the only sign for the presence of primary cancer elsewhere and in four of them FNA revealed malignant cells prior to the diagnosis of internal carcinoma. In one case, FNA demonstrated only inflammatory cells while surgery revealed adenocarcinoma associated with inflammation. The sensitivity of FNA in diagnosing malignant umbilical nodule, and the accuracy of FNA findings were 98.2%, while the predictive value of a FNA cytologic finding of malignancy was 100%. It is recommended that an umbilical nodule should alert the clinician to the possibility of malignancy and FNA should be performed as the first diagnostic procedure.This safe, rapid, reliable, and inexpensive method may diagnose ma‐ lignancy and preclude the need for umbilical biopsy or more complicated diagnostic intervention.
Gastroduodenal artery‐duodenal fistula: A complication of continuous floxuridine (FUDR) infusion into the gastroduodenal artery
Authors: Kernstine Kemp H. , Kryjeski Sheila R. , Hall Lorin J. , Larson Richard E. , Saylor Howard L. , Fortuny Ignacio E. 
Published: February 2007

AbstractThis case report describes a patient who for 31 months has received regional intrahepatic chemotherapy from a continuous infusion pump and who developed a gastroduodenal artery‐duodenal fistula, a previously unreported complication of regional infusion therapy. The patient presented with signs and symptoms of upper gastrointestinal bleeding. The clinical evaluation and management are described. An angiogram was performed through the auxillary septum to identify the source of bleeding. The possible etiologic factors in this case are discussed. We believe that this complication will continue to be rare, but health care providers should be aware of its presentation and its preferred method of evaluation and management.
Clinicopathological features of elevated lesions of the duodenal bulb
Authors: Matsuura Hiroshi , Kuwano Hiroyuki , Kanematsu Takashi , Sugimachi Keizo , Haraguchi Yukiaki 
Published: February 2007

AbstractWe present here our findings on patients with an elevated lesion of the duodenal bulb. All these patients were treated in our clinics between the years 1984 and 1988. These lesions were present in 36 of 8,802 patients who underwent upper gastrointestinal pan‐endoscopy. Two patients had a duodenal carcinoma, 2 an adenoma, and 1 a Brunner's gland adenoma. There were 15 with a hyperplastic polyp, 3 with a heterogenic gastric mucosa, 3 with Brunner's gland hyperplasia, 6 with duodenitis, and 4 with regenerative mucosa. Among these 36 lesions, only 69% (25 lesions) were evident on the upper gastrointestinal X‐ray series. Adenoma and Brunner's gland adenoma were of a pedunculated form of the gross type and had an irregular surface mucosa. Both duodenal carcinomas were detected by endoscopic biopsy and were resected. Histologically, these lesions were limited to the submucosal layer and were of the non‐pedunculated polypoid form, but there were no other characteristic endoscopic features, in comparison with other elevated lesions. Thus, upper gastrointestinal endoscopy with routine observations of the duodenal bulb plus endoscopic biopsy will lead to a definite diagnosis of these elevated lesions and to the early detection and treatment of this rare malignant lesion.
Malignant melanoma occurring during pregnancy: A report of the Northern Israel oncology center (1968–1988)
Authors: Stein Moshe , Fried Getta , Borovik Riva , Halpern Joshua , Beck Danny , Robinson Eliezer 
Published: February 2007

AbstractMedical records of seven patients treated within a 20 year period for malignant melanoma during pregnancy were reviewed. No significant detrimental prognostic effects could be attributed to pregnancy. The current literature on melanoma and pregnancy is discussed. Based on this, pregnancy seems not to be contraindicated in melanoma patients.
Adenocarcinoma arising in Barrett's esophagus
Authors: Harvey James C. , Kagan A. Robert , Hause Donald , Sachs Todd , Frankl Harold 
Published: February 2007

AbstractA review of nine adenocarcinomas of the esophagus arising in Barrett's epithelium was undertaken. We found the disease among white males disproportionately. Risk factors and incidence rate remain to be clarified. Only one patient was in a surveillance program and only he had carcinoma discovered “early.” He still survives while only one of the eight whose diagnosis followed investigation of symptoms remains alive.
Obstructing carcinoma of the cecum
Authors: Rovito Peter F. , Verazin Gary , Prorok Joseph J. 
Published: February 2007

AbstractCarcinoma of the cecum, the third most common location for malignancy of the large bowel, was examined with attention centered upon cecal cancers producing obstruction. Reviewing 136 patients revealed 11 obstructing lesions (8.1%) presenting as distal small bowel obstructions. The mean age of the patients was 74 years. All but one patient had resection for cure which consisted of a right hemicolectomy with ileotransverse colostomy. There was no operative mortality or significant morbidity. Bowel obstruction due to cecal carcinoma is an infrequent occurrence arising in elderly patients and carries a poor survival rate due to advanced disease at the time of diagnosis and treatment.
Rat liver tolerance for partial resection and intraoperative radiation therapy: Regeneration is radiation dose dependent
Authors: Bossola Maurizio , Merrick Hollis W. , Eltaki Ahmed , Bellantone Rocco , Milligan Andrew J. , Doglietto Glovanni B. , Conran Philip , Dobelbower Ralph R. , Crucitti Francesco 
Published: February 2007

AbstractWe studied the feasibility of delivering a large single dose of intraoperative radiation as an adjuvant to partial hepatic resection. Intraoperative radiation therapy (IORT) was delivered to the remaining liver of 84 rats after partial hepatectomy to determine the acute and chronic effects of treatment on blood chemistry values, histology, survival, hepatic regeneration, and cellular appearance of the normal liver. Transient elevations in SGOT, SGPT, and alkaline phosphatase were attributed both to hepatectomy and to liver parenchymal damage induced by IORT. Microscopic examination upon necropsy, performed at frequent intervals post‐treatment, revealed hepatic capsular thickening with some alteration of liver architecture mainly underneath the capsule, with localized inflammation and some areas of necrosis. Survival in all groups was 100% at 45 days. Liver weight increase proved to be dose‐dependent and displayed a biphasic pattern. This study demonstrated that IORT is a feasible adjunct to surgical resection of the liver in the rat model.
Ampullary carcinoma in patients under 50 years of age with a poor prognosis
Authors: Yamaguchi Koji , Enjoji Munetomo 
Published: February 2007

AbstractClinicopathologic features of 145 Japanese patients with ampullary carcinoma were compared among three age groups. The 145 patients were divided into three groups by the patient's age at the time of operation; there were 24 patients in group I (younger) aged ⩽50 years, 99 in group II (ordinary) aged 51‐69, and 22 in group III (elderly) aged ⩾70. The three groups showed no significant difference in sex, icterus, duration of icterus, size of the tumor, year of operation, macroscopic type, histopathologic type, tumor margin, lymphatic permeation, venous invasion, or pancreatic invasion. The survival curve of group I was worse than those of groups II and III. Multivariate regression analysis using II prognostic variables failed to reveal that the age of the patient at the time of operation was an independent factor. The younger patients aged ⩽50 fared worse than the elderly patients aged ⩾70, because the group I tumors included a significantly greater number of advanced ampullary carcinoma with more frequent perineural invasion than did the group III tumors.
Metastatic tumors of the umbilicus: A review 1830–1989
Authors: Shetty M. R. 
Published: February 2007

AbstractUmbilical metastases from known and unknown primary cancers are rare. The eponym “Sister Mary Joseph's nodule” has been used by generations of physicians. The first reports of this clinical sign were from Walshe in 1846. A review of the literature revealed 265 cases from then until 1989. Only 85 cases of umbilical metastasis from unknown primary tumors were found. This review should help us to focus on the common and uncommon primary sites in the diagnosis of patients with this finding. A single case report and the work‐up for the hidden primary tumor are described.
Recurrence of resected esophagogastric adenocarcinoma: Results of re‐resection
Authors: Kurtzman Scott H. , Turnbull Alan D. , Burt Michael , Bains Manjit S. 
Published: February 2007

AbstractIsolated local recurrence following potentially curative resection for carcinoma of the esophagus or esophagogastric junction does not necessarily imply pending systemic disease and early demise. While radiation alone or in combination with chemotherapy is standard treatment for such patients, resection is another available option. Resection may also be a consideration should localized disease persist after non‐operative therapy in the absence of metastases. A 5 year retrospective review was performed examining 204 resections performed prior to 1989. Only 5 patients underwent resection of locally recurrent esophagogastric (EG) adenocarcinoma during this period. No squamous carcinoma recurrences were resected. One patient is well 15 months later while another died at 18 months of other causes without recurrence. Recurrence after re‐resection occurred at 8, 11, and 24 months in the 3 other patients. Although there were no postoperative deaths, major complications occurred in 4 patients. All 5 patients swallowed normally after operation.
Surgical wound infection and cancer among the elderly: A case control study
Authors: Huchcroft Shirley A. , Nicolle Lindsay E. , Cruse Peter J. E. 
Published: February 2007

AbstractSurgical wound infection occurs in fewer than 5% of operations. Nevertheless, it represents the second most common type of hospital‐acquired infection and results in increased morbidity and mortality. As with all nosocomial infections, the rate of surgical wound infection increases with age. Patients over 65 years of age run an approximately 15% risk of surgical wound infection.Two‐thirds of patients with invasive cancer other than non‐melanotic skin cancer are aged 65 years and over. Over half of them are treated surgically for their cancer. Cancer and other chronic diseases have been cited as possible causes of the increased risk of nosocomial infection among the elderly.Using the Foothills Hospital Wound Study Data Base as the sampling frame, we conducted a case‐control study of surgical wound infection and cancer among the elderly. Cancer was found not to be a risk factor for surgical wound infection. The results are discussed in relation to the role of immunity in both disorders.
The use of interferon alpha‐C in patients with metastatic renal cell carcinoma arising in a congenital solitary kidney
Authors: Merimsky Ofer , Merimsky Ephraim , Chaitchik Samario 
Published: February 2007

AbstractThree cases of renal cell carcinoma in a congenital solitary kidney are presented. Treatment with recombinant interferon alpha‐C was administered in two cases. A subjective response occurred in one case. The literature is reviewed with respect to treatment options and prognostic factors.