bluuebunny/crossref_metadata_2025_split huggingface dataset:
Рецензия на: Традиции преображающего видения в иудаизме и христианстве / ред. Т. Гарсии-Уидобро, А. А. Орлова. Т. 1. М.: Институт св. Фомы, 2020. (Иудейские корни христианской мистики). 320 с. ISBN 978-5-6042300-6-0
Authors: Вевюрко И. 
Published: February 2025

Одна из новых книг, выпущенных за последнее время на русском языке под редакцией иезуита Томаса Гарсии-Уидобро и Андрея Александровича Орлова, русского эмигранта, работающего в Университете Маркетт (США), является сборником статей, написанных этими двумя авторами (а также в соавторстве с А. Голициным) и переведенных на русский язык Г. В. Вдовиной и И. Д. Колбутовой.Авторы не в первый раз обращаются к теме преображающего видения, а точнее, бьют в эту точку с известным постоянством, не только дополняя свои исследования новыми ценными данными, но порой и перепечатывая их слово в слово в новых сборниках (пример чего нам придется привести ниже). Это, разумеется, не умаляет достоинства опубликованных исследований, но вызывает некоторые вопросы, связанные с организацией научной деятельности, которые мы также обсудим кратко в этой рецензии.
One of the new books recently published in Russian under the editorship of Jesuit Tomás García-Huidobro and Andrei Alexandrovich Orlov, a Russian emigrant working at Marquette University (USA), is a collection of articles written by these two authors (and also co-authored with A. Golitsin) and translated into Russian by G. V. Vdovina and I. D. Kolbutova. It is not the first time that the authors address the theme of transforming vision, or rather, they hit this point with a certain constancy, not only supplementing their research with new valuable data, but sometimes reprinting them word for word in new collections (an example of which we will have to give below). This, of course, does not detract from the merits of the published studies, but raises some questions related to the organization of scientific activity, which we will also discuss briefly in this review.
Аналіз активності системного запалення та ренін-ангіотензин-альдостеронової системи в пацієнтів із порушеннями ритму серця
Authors: Marchenko O. Ya. 
Published: February 2025

The aim –to compare the systemic inflammation activity and the state of renin-angiotensin system in patients with paroxysmal and persistent forms of atrial fibrillation and flutter that are associated to arterial hypertension and their effect on sympathetic nervous system activation.Materials and methods. 147 patients were involved into the study. 103 of them had rhythm disorders. Patients with arrhythmias were divided into three main groups depending on the form and type of arrhythmia. Control groups included patients with arterial hypertension, but without studied arrhythmias, and practically healthy people. The activity of systemic inflammation was determined by the level of highly sensitive C-reactive protein in blood serum. Expression of the renin-angiotensin system activity – according to the angiotensin-converting enzyme activity. Patients underwent Holter electrocardiogram monitoring to register the heart rhythm and it’s variability. Results. Among patients with rhythm disorders, statistically higher levels of CRP and ACE were recorded compared to patients of control groups. The highest rates were in the group of patients with a persistent form of atrial fibrillation. According to the results of the Holter ECG, a significant mathematical difference was recorded between the average heart rate and SDNN in patients with arrhythmias and a tendency to increase the maximum heart rate.Conclusions. It was detected that in patients with atrial fibrillation and flutter on the background of arterial hypertension, compared to patients with hypertension without rhythm disturbances or healthy people, there is a higher intensity of systemic inflammation and increased activity of the renin-angiotensin system and, as a result, activation of the sympathoadrenal system.
Bone mineral density and sex hormone binding globulin as potential mediators of the causal effect of urolithiasis on osteoporosis risk: a Mendelian randomization
Authors: Guo Jiawei , Chen Xinyu , Yi Xinping , Dou Yongqi , Xiong Yongjiang , Zhao Tao 
Published: February 2025

ObjectiveOsteoporosis (OP) and urolithiasis (UL) are two metabolic diseases that are prevalent globally. Previous observational studies have found a relationship between these two diseases that increases the risk of each other, but whether there is a direct causal link is still unclear. Currently, research on the mechanisms of these two diseases mainly focuses on external factors such as diet and environment. Thus, this study used two-sample mendelian randomization (TS-MR) in conjunction with mediation analysis to explore the causal relationship between OP and UL and their potential mechanisms. Mediators included total body bone mineral density (T-BMD), sex hormone binding globulin (SHBG), serum 25-hydroxyvitamin D (serum 25(OH)D) levels, and calcium supplements.MethodWe acquired UL-related and BMD-related single nucleotide polymorphisms (SNPs) from the MRC IEU Open Genome-Wide Association Study (GWAS) database. The primary SNPs data of osteoporosis were from the FinnGen database. To clarify the mediators involved in the link between OP and UL, we performed a MR investigation. The primary approach to analysis was inverse variance weighting (IVW). In addition, we also used another osteoporosis data from UK biobank (UKB) to further verify the mediating role.ResultsWe discovered that there was a 14% increase in the incidence of OP in UL patients using the IVW approach. (FinnGen: OR = 1.1491,95% CI: 1.0544-1.2523; UKB: OR = 1.1339,95% CI: 1.0266-1.2523). Among different age groups, except for the 15-45 age group, we observed that UL increased the risk of low bone mineral density. Similarly, consistent results were also observed in bone mineral density at different sites. Mediation analysis showed that 50% of the effect of UL on OP was mediated by BMD levels (FinnGen:49.68%; UKB:56.45%). In addition, we also observed an important mediating effect between sex hormone binding globulin (SHBG) on UL and an increased risk of OP, but with a lower proportion of mediators (FinnGen:2.406%; UKB:2.595%). Furthermore, we also found decreased serum 25 (OH) D levels in UL patients, but not its mediating effect.ConclusionsIn conclusion, the study establishes a direct causal link between urolithiasis and OP, independent of environmental factors. Furthermore, mediation analysis showed that bone density and SHBG levels partially mediated the risk of OP in UL patients, suggesting that both mediators may be involved in the mechanism of UL-induced OP. These findings broaden the understanding of the link between the UL and the OP. Thus, regardless of lifestyle, urolithiasis patients should remain vigilant about the risk of OP and consider regular OP screening.
Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach
Authors: Mandal Saurav , Chanu Waribam Pratibha , Natarajaseenivasan Kalimuthusamy 
Published: February 2025

BackgroundAlthough the SARS-CoV-2 and dengue viruses seriously endanger human health, there is presently no vaccine that can stop a person from contracting both viruses at the same time. In this study, four antigens from SARS-CoV-2 and dengue virus were tested for immunogenicity, antigenicity, allergenicity, and toxicity and chosen to predict dominant T- and B-cell epitopes.MethodsFor designing a multi-epitope vaccine, the sequences were retrieved, and using bioinformatics and immunoinformatics, the physicochemical and immunological properties, as well as secondary structures, of the vaccine were predicted and studied. Additionally, the three-dimensional structure was estimated, improved upon, and confirmed using bioinformatics methods before being docked with TLR-2 and TLR-4. Eight helper T-cell lymphocyte (HTL) epitopes, ten cytotoxic T-cell lymphocyte (CTL) epitopes, nine B-cell epitopes, and TLR agonists were used to create a new multi-epitope vaccine. Furthermore, according to the immunological stimulation hypothesis, the vaccine could stimulate T and B cells to create large quantities of Th1 cytokines and antibodies.ResultsThe study indicates that the developed vaccine is a favorable vaccine candidate with antigenicity, immunogenicity, non-toxicity, and non-allergenicity properties. The vaccine construct was made up of 460 amino acids, had an MW of 49391.51 Da, a theoretical pI of 9.86, and the formula C2203H3433N643O618S18, a lipid index of 39.84, a GRAVY of −0.473, an aliphatic index of 63.80, and an instability index of 39.84, which classifies the protein to be stable.ConclusionThe acquired data showed that both vaccine designs had a considerable chance of preventing the co-infection of SARS-CoV-2 and dengue virus and that they demonstrate good results following in-silico testing. Furthermore, the vaccine may be an effective strategy in preventing SARS-CoV-2 and dengue since it can cause noticeably high levels of Th1 cytokines and antibodies.
ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity
Authors: Czárán Domonkos , Sasvári Péter , Lőrincz Kende , Ella Krisztina , Gellén Virág , Csépányi-Kömi Roland 
Published: February 2025

ObjectiveContact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes. Our group previously demonstrated that the leukocyte-specific GTPase-activating protein ARHGAP25 regulates phagocyte effector functions and is crucial in the pathomechanism of autoantibody-induced arthritis. Here, we investigate its role in the pathogenesis of the more complex inflammatory process of contact hypersensitivity.MethodsFor sensitization, the abdomens of wild-type and ARHGAP25 deficient (KO) mice on a C57BL/6 background, as well as bone marrow chimeric mice, were coated with 3% TNCB (2-chloro-1,3,5-trinitrobenzene) or acetone in the control group. After five days, ears were treated with 1% TNCB for elicitation. Swelling of the ears caused by edema formation was evaluated by measuring the ear thickness. Afterward, ears were harvested, and histological analysis, investigation of leukocyte infiltration, cytokine production, and changes in relevant signaling pathways were carried out. ARHGAP25 expression at the mRNA and protein levels was measured using murine ear and human skin samples.ResultsARHGAP25 expression increased in human patients suffering from contact dermatitis and in contact hypersensitivity induced in mice. Our data suggest that ARHGAP25 expression is infinitesimal in keratinocytes. In the CHS mouse model, the absence of ARHGAP25 mitigated the severity of inflammation in a leukocyte-dependent manner by reducing the infiltration of phagocytes and cytotoxic T cells. ARHGAP25 altered cytokine composition in the sensitization and elicitation phase of the disease. However, this protein did not affect T cell homing and activation in the sensitization phase.ConclusionOur findings suggest that ARHGAP25 is essential in developing contact hypersensitivity by modulating the cytokine environment and leukocyte infiltration. Based on these findings, we propose ARHGAP25 as a promising candidate for future therapeutic approaches and a potential ACD biomarker.
Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers
Authors: Kyttaris Vasileios , Wallace Daniel J. , Khosroshahi Arezou , Concoff Andrew , Wilson Nicole , Liu Chau Ching , Manzi Susan , Ahearn Joseph , Taghavi Sepehr , Warsi Touba , Park Stanley , Schleif Christine , Partain Brittany D. , O’Malley Tyler 
Published: February 2025

IntroductionT Cell autoantibodies, TIgG and TIgM, as well as the T Cell-bound complement protein fragment C4d (TC4d) are novel diagnostic biomarkers that have demonstrated high specificity and sensitivity for SLE. The present study aims to characterize the clinical performance characteristics of the emergent T Cell biomarkers in a multi-center clinical validation cohort.MethodsA cohort of 400 adult patients enrolled across 3 academic and 2 community-based autoimmune rheumatic centers, comprised of 105 SLE patients, 173 patients with autoimmune rheumatic diseases (ARD), 83 apparently healthy volunteers (AHV) and 39 other (non-autoimmune) disease (OD) controls were tested for TC4d, TIgG, TIgM and an extensive autoantibody profile. Diagnostic specificity was assessed against the ARD, AHV and OD groups, individually. Semi-quantitative flow cytometry analysis included TIgG and TIgM autoantibodies, cell-bound complement activation products (CB-CAPs), TC4d, erythrocyte-bound C4d (EC4d) and B lymphocyte-bound C4d (BC4d). Conventional autoantibodies and soluble complement proteins, C3 and C4, were assessed by ELISA and immunoturbidimetry, respectively.ResultsROC analysis distinguishing ANA-positive (ANA+) SLE (N = 91) from ARD, TIgG, BC4d and TC4d demonstrated AUC values 0.81, 0.80 and 0.79, respectively, outperforming anti-dsDNA (0.72), C3 (0.69), TIgM (0.67), C4 (0.66) and anti-Smith (0.61). A similar ranking of discriminatory power was observed in ROC analysis distinguishing ANA+ SLE vs. OD as well as ANA+ SLE vs. AHV. At 95% diagnostic specificity for SLE vs. AHV, the sensitivity (95% CI) of TC4d, TIgG and TIgM for SLE was 58.1% (48.1 – 67.7%), 31.4% (22.7 – 41.2%) and 29.5% (21.0 – 39.2%), respectively. The T Cell SLE biomarkers uniquely identified 19% (20/105) of SLE patients who were otherwise negative (serologically inactive) for conventional SLE autoantibodies and had normal serum complement levels. Among the serologically inactive SLE subset, the T Cell SLE biomarkers collectively identified 53% of subjects.ConclusionsThe novel SLE biomarkers TC4d, TIgG and TIgM consistently outperform conventional markers across multiple cohorts. Their integration enhances diagnostic sensitivity, especially in SLE-specific autoantibody negative patients with normal complement levels. When coupled with conventional biomarkers, these novel tests may enable earlier and more accurate SLE detection, leading to more timely diagnosis and treatment.
Phase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in older patients with newly diagnosed acute myeloid leukemia
Authors: Liu Qingyang , Yang Jingjing , Lv Lei , Zhang Xiawei , Li Meng , Xu Lingmin , Huang Sai , Jing Yu , Dou Liping 
Published: February 2025

IntroductionOlder patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets. However, their effects remains unclear as induction therapy for AML.MethodsPreviously untreated AML patients aged 60 years and over (N=40) were enrolled into this single arm, open-label, phase 2 study to evaluate the clinical efficacy and safety of chidamide combined with CAG and venetoclax-azacitidine (referred to as CACAG-VEN) in elderly AML patients (ClinicalTrials.gov:NCT05659992). All patients received induction treatment with aclarubicin (10 mg/m2/d on days 1, 3, and 5), azacitidine (75 mg/m2 on days 1–7), cytarabine (75 mg/m2 bid on days 1–5), chidamide (30 mg, twice/week for 2 weeks), and venetoclax (100 mg on day 1, 200 mg on day 2, 400 mg on days 3–14). Granulocyte colony-stimulating factor 5 mg/kg/day was administered.ResultsTheoverall response rate was 97.5%, with a composite complete response (CRc) rate of 85.0% after one cycle of CACAG-VEN. Patients with adverse risk according to the ELN guidelines had CRc rates of 81.3%. No patients experienced early death within 30 days of therapy initiation. Grade 3 - 4 non-hematological adverse events included febrile neutropenia in 15 (37.5%) of 40 patients, pneumonia in three (7.5%), sepsis in two (5.0%) and blood bilirubin increase in one (2.5%). The 12-month overall survival rate was 73.4% (95% CI: 55.9–84.8%). The median time to recovery was 15.0 (IQR 10.0-19.5) days for platelets ≥ 20000/mL and 13.0 (IQR 10.5-17.0) days for an absolute neutrophil count ≥ 1000 cells/mL after induction therapy.DiscussionIn conclusion, chidamide in combination with CAG and venetoclaxazacitidine was effective and well tolerated in elderly patients with AML.Clinical trial registrationhttps://www.clinicaltrials.gov/, identifier NCT05659992.
Effects of intermittent theta burst stimulation on upper limb motor recovery in early stroke patients: an fNIRS study
Authors: Liu Menghui , Wan Chunxiao , Wang Chunyan , Li Xinyi 
Published: February 2025

ObjectiveTo explore the recovery of upper limb motor function and the changes in cortical functional connectivity in patients with early subcortical small infarcts accompanied by severe upper limb motor dysfunction (PESSUM) after intermittent theta burst stimulation (iTBS) via functional near-infrared spectroscopy (fNIRS) and to explore the related mechanisms.MethodsWe enrolled 56 subcortical ischemic stroke patients with FMA-UE ≤28 and randomly assigned them to receive either genuine (TG, n = 29) or sham (CG, n = 23) iTBS plus standard rehabilitation over 8 days. fNIRS was used to monitor cerebral HbO, HbD, and HbT concentrations, and RSFC changes were analyzed. The FMA-UE and MBI scores were used to evaluate upper limb motor function and daily activities. Intergroup comparisons were conducted using independent samples t tests, whereas intragroup comparisons were performed using paired samples t tests or Mann–Whitney U tests. The trend of the RSFC changes was analyzed via repeated-measures Analysis of Variance (ANOVA).ResultsBoth groups showed significant improvements in FMA-UE and MBI scores postintervention (p &lt; 0.001). The TG had higher MBI scores than the CG (p = 0.005). fNIRS revealed accelerated cyclical changes in cortical activity in the TG.ConclusioniTBS significantly improved motor function and daily living ability in stroke patients, supporting a role for iTBS in promoting neural repair by accelerating cortical recovery cycles. This study provides evidence that iTBS is an effective rehabilitation strategy poststroke.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=169674, ChiCTR2200060955.
Persistent homology for MCI classification: a comparative analysis between graph and Vietoris-Rips filtrations
Authors: Bhattacharya Debanjali , Kaur Rajneet , Aithal Ninad , Sinha Neelam , Gregor Issac Thomas 
Published: February 2025

IntroductionMild cognitive impairment (MCI), often linked to early neurodegeneration, is associated with subtle disruptions in brain connectivity. In this paper, the applicability of persistent homology, a cutting-edge topological data analysis technique is explored for classifying MCI subtypes.MethodThe study examines brain network topology derived from fMRI time series data. In this regard, we investigate two methods for computing persistent homology: (1) Vietoris-Rips filtration, which leverages point clouds generated from fMRI time series to capture dynamic and global changes in brain connectivity, and (2) graph filtration, which examines connectivity matrices based on static pairwise correlations. The obtained persistent topological features are quantified using Wasserstein distance, which enables a detailed comparison of brain network structures.ResultOur findings show that Vietoris-Rips filtration significantly outperforms graph filtration in brain network analysis. Specifically, it achieves a maximum accuracy of 85.7% in the Default Mode Network, for classifying MCI using in-house dataset.DiscussionThis study highlights the superior ability of Vietoris-Rips filtration to capture intricate brain network patterns, offering a robust tool for early diagnosis and precise classification of MCI subtypes.
Electrically evoked mismatch negativity from speech stimuli as an objective measure of cochlear implant performance
Authors: Zhang Lichun , Stauga Pattric , Mißler David , Ehrt Karsten , Großmann Wilma , Mlynski Robert , Schmidt Florian Herrmann 
Published: February 2025

IntroductionCochlear implant (CI) success is often assessed using subjective tests like word recognition scores (WRS). However, these tests are unsuitable for children, non-native speakers, and individuals with cognitive impairments. Mismatch negativity (MMN), an objective measure of cortical auditory processing, offers a promising alternative for evaluating speech perception. This study aimed to assess speech perception in CI patients using MMN and examine its correlation with WRS.MethodsThe study included 23 ears from CI users fitted for at least six months. Speech stimuli were presented via direct audio input to the CI processor at 70 dB nHL using an MMN paradigm. The syllables ‘ba’ (standard) and ‘da’ (deviant) served as stimuli. MMN amplitude and latency were analyzed, and their correlation with WRS was examined.ResultsA significant correlation was observed between WRS and MMN responses. CI users with lower WRS scores exhibited reduced MMN amplitudes and prolonged latencies compared to those with higher scores, indicating impaired cortical speech processing.DiscussionThese findings suggest that speech-induced MMN could serve as an objective tool for assessing speech perception in CI users. MMN provides valuable insights for optimizing CI fitting, particularly for patients unable to undergo subjective testing. Integrating MMN into clinical practice could improve speech perception outcomes and enhance the quality of life for CI users.
Impact of Ligilactobacillus salivarius Li01 on benzo[a]pyrene-induced colitis, based on host-microbiome interactions in Mongolian gerbils
Authors: Huang Yilun , Yang Can , Fu Bingmeng , Guo Honggang , Chen Yunxiang , Xu Dengfeng 
Published: February 2025

BackgroundProbiotics supplementations have been regarded as an effective strategy for colitis treatment. However, the effect of Ligilactobacillus salivarius Li01 on benzo[a]pyrene (BaP)-induced colitis in Mongolian gerbils remains unclear. In this study, we leverage a BaP-induced model of colitis that exhibits significant remission following Ligilactobacillus salivarius Li01 intervention, to conduct an animal experiment that integrates histopathological assessment, inflammatory cytokines, 16S rRNA sequencing, targeted metabolomic profiling to investigate the relationship between Ligilactobacillus salivarius Li01, gut microbiota, and colitis.ResultsWe demonstrated that the improvements in colon histopathological assessment and inflammatory cytokines by Ligilactobacillus salivarius Li01 supplementation are accompanied by alterations in gut microbiota structure marked by increased abundance of strains with probiotic potential belonging to Bifidobacterium and Eubacterium_coprostanoligenes. Targeted metabolomic profiling analysis showed that Ligilactobacillus salivarius Li01 supplementation increases the concentration of acetic, propionic, butyric, and valeric acid. Correlation analysis showed that the alteration in the indicators associated with colitis is closely correlated to the changed microbial taxa and short-chain fatty acids (SCFAs).ConclusionThese data highlighted that Ligilactobacillus salivarius Li01 supplementation ameliorated the BaP-induced colitis, probably via modulating the structure of gut microbiota and promoting the production of SCFAs. Our findings provide preliminary evidence for a possible therapeutic strategy for the treatment of colitis based on host-microbiome interactions.