bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating the High Seas of Mental Health: Exploring the Prevalence of Depression, Stress, Anxiety, and Burnout Among Indian Seafarers
Authors: Kavita Sharma  
Published: April 2024

The primary objective of this study is to investigate the extent to which depression, stress, anxiety, and burnout in Indian seafarers. The study collected data from 109 Indian seafarers through Google Forms from March 2023 to April 2023. Descriptive statistics and inferential statistics were used to summarize the data based on selected demographic factors. The results showed that Indian seafarers suffered from mild depression (Mean =13.54) Seafarers also suffer from moderate levels of anxiety (Mean= 10.81). The levels of stress are found to be of normal level (Mean=13.28). The average scores for the components of burnout, namely Disengagement, and Exhaustion, among seafarers are 20.03 (SD= 3.673) and 20.43 (SD= 4.051) respectively. These findings suggest that seafarers exhibit moderate levels of burnout. Also, the correlational analysis shows a positive moderate correlation between total scores of depression, anxiety, stress, and components of Burnout with a value of 0.392 at a 1 % level of significance. The study highlights the need for mental health interventions and support services for seafarers to prevent and manage mental health issues in this population.
ANALISIS KEKUATAN STRUKTUR JOINER TUAV AEROSTAR DENGAN PERBANDINGAN MATERIAL KOMPOSIT CARBON FIBER DAN GLASS FIBER MENGGUNAKAN METODE ELEMEN HINGGA
Authors: Banowati Lies 
Published: April 2024

PTTA merupakan pesawat terbang yang mampu terbang dengan waktu tertentu tanpa dikendarai oleh pilot. Kebutuhan terhadap PTTA merupakan salah satu tuntutan perkembangan teknologi penerbangan. Untuk melakukan proses tersebut, Dislitbangau memiliki wadah yang disebut Flying Test bed (FTB). FTB adalah suatu wadah untuk menguji suatu konsep sistem pesawat yang telah dirancang, sebelum diaplikasikan pada pesawat sesungguhnya.
Pada studi ini, penelitian kekuatan struktur joiner PTTA dengan metode elemen hingga menggunakan software Patran/Nastran. Penentuan aircraft load didapat dari perkalian MTOW dengan load factor sebesar 3.8 dan di distribusikan pada tiap – tiap nodal spar menggunakan metode Schrenk Metode Schrenk ini adalah sebuah metode perhitungan pendekatan yang digunakan untuk menghitung distribusi lift sepanjang span. Selanjutnya distribusi lift tersebut digunakan untuk menghitung kekuatan struktur untuk mengetahui kekuatan joiner Aerostar dengan parameter failure index. Material yang digunakan CFRP dan GFRP dengan ketebalan 8, 10, dan 12 layer. Hasil perhitungan Patran/Nastran menunjukan bahwa Analisis dengan arah serat 0?/90? ketebalan 12 layer material CFRP memiliki nilai failure index terkecil yaitu 0.67 dimana material kuat dalam menahan beban. Hasil nilai failure index terbesar diperoleh material GFRP 8 layer dengan arah serat 0/45 dan quasi-isotropic sebesar 2.24 dimana material tersebut tidak kuat dalam menahan beban pada struktur joiner
ANALISIS ORIENTASI SERAT MATERIAL KOMPOSIT WOVEN E-GLASS STRUKTUR UPPER SKIN SAYAP PESAWAT WIG 2 SEATER DENGAN METODE FAILURE INDEX TSAI-HILL MENGGUNAKAN SOFTWARE PATRAN/NASTRAN
Authors: Banowati Lies 
Published: April 2024

Studi mengenai analisis orientasi arah serat material komposit woven e-glass struktur upper surface skin sayap pesawat wig 2 seater dilakukan dengan metode failure index tsai-hill menggunakan software Patran/Nastran. Pada studi ini beban yang digunakan berupa beban up bending yang distribusikan pada bagian lower surface skin. Beban up bending digunakan untuk menghitung analisis stress maximum, defleksi maximum, dengan parameter failure index. Material yang digunakan woven E-glass dengan ketebalan 4, 6, 8, 10 layer arah serat 0?/90? , 0°/±45° dan Quasi-Isotropic kondisi batas yang digunakan adalah fix pada bagian sambungan wing root. Hasil perhitungan Patran/Nastran menunjukan bahwa analisis upper surface skin dan wig 2 seater dengan arah serat 0°/90°, 0°/±45° dan Quasi-Isotropic ketebalan 4, 6, 8, 10 layer material woven e-glass didapatkan hasil stress maximum tertinggi yang diperoleh pada ketebalan 4 layer (0.948 mm) arah serat 0°/±45° sebesar 481 MPa dan Hasil stress maximum terendah diperoleh pada ketebalan 10 layer (2.37 mm) arah serat 0°/90° sebesar 139 MPa. Hasil defleksi maximum tertinggi diperoleh pada ketebalan 4 layer (0.948 mm) arah serat 0°/±45° sebesar 725 mm. Hasil stress maximum terendah diperoleh pada ketebalan 10 layer (2.37 mm) arah serat 0°/90° sebesar 217 mm. Struktur upper surface skin sayap pesawat WIG 2 seater yang memenuhi kriteria failure index hill didapat pada ketebalan 10 layer (2.37 mm) arah serat 0°/90°, 0°/±45° dan quasi-isotropic. Pada ketebalan 10 layer (2.37 mm) arah serat 0°/90° diperoleh failure index hill sebesar 0.84 dan ketebalan 10 layer (2.37 mm) arah serat 0°/±45°, quasi-isotropic diperoleh sebesar 0.89. nilai failure index tsail-hill pada material woven E-glass memenuhi nilai failure index yaitu kurang dari satu (? 1).
The risk-based operational safety strategy for Perkin-Elmer/Cetus DNA Thermal Cycler PCR systems
Authors: Pino Tarragó Julio Cesar , Saraiba Núñez Leider Inocencio , Moreno Pino Maira Rosario , Arbella Feliciano Yorley 
Published: April 2024

Introduction: this article was conducted in the field of polymerase chain reaction (PCR) test safety, where it is essential to understand the contribution and impact of risk analysis methods to improve test safety medical diagnosis at the institutional level. In this context, the current study focuses on failure modes and effects analysis (FMEA) applied to the Perkin-Elmer/Cetus deoxyribonucleic acid (DNA) thermocycler.Objective: to describe the application of FMEA to improve the operational safety of Perkin-Elmer/Cetus DNA thermal cyclers used in medical diagnostics in ataxic patients. Methods: to carry out this study, a methodology based on an exhaustive review of the scientific literature available in academic databases and relevant sources was used. Previous studies on FMEA analysis of DNA thermocyclers in common and expanded forms were collected and analyzed.Results: the results obtained demonstrated that FMEA is an effective tool to identify and evaluate possible failure modes of Perkin-Elmer/Cetus DNA thermal cyclers. Several defects were identified and their consequences, causes and classification based on their severity and frequency were determined. Likewise, corrective actions are proposed to reduce the identified risks.Conclusions: early identification of possible failure modes and implementation of corrective actions can reduce risk and guarantee the quality of the diagnoses carried out and therefore improve operational safety
Perceived satisfaction of users of pharmaceutical services in Yopal Casanare at COVID 19
Authors: Cruz Medina Wilquer Herney , Herrera Hernández Sonia Ibanova 
Published: April 2024

User satisfaction has become an indispensable requirement and even more with the appearance of COVID 19, companies were forced to improve the quality of their services. In Colombia, and especially the department of Casanare, there is a high degree of dissatisfaction with health sector companies. For this reason, the research project aimed to know the degree of perceived satisfaction of users of pharmaceutical services in the city Yopal Casanare. Through online questionnaires scale of Likert, applied to 133 users of pharmacies and drugstores of the private sector of the city. Non-probability sampling was used to calculate the sample size for convenience. It is also evident that there is a relationship between the degree of perceived satisfaction vs order of arrival and priority in care. In short, to meet the needs of users of pharmaceutical services in a shorter time; it is one of the alternatives identified for improving the degree of satisfaction in drugstores in the city of Yopal
Comparative Assessment of Laparoscopic and Endoscopic Cooperative Surgery With Laparoscopic Wedge Resection for the Treatment of Gastric Submucosal Tumors
Authors: Enomoto Masaya , Iwasaki Kenichi , Barroga Edward , Sakurai Toru , Yamada Erika , Miyoshi Kenta , Shimoda Yota , Mazaki Junichi , Hoshino Akihiro , Hayashi Yutaka , Ishizaki Tetsuo , Yamada Tesshi , Nagakawa Yuichi 
Published: April 2024

Background
The most commonly performed surgical resection technique for gastric submucosal tumors (gSMTs) is laparoscopic wedge resection (LWR). Notably, laparoscopic and endoscopic cooperative surgery (LECS) is a surgical procedure that combines laparoscopic gastric resection with an endoscopic submucosal dissection for the local resection of gastric tumors, which provides appropriate and minimal surgical resection margins.

Methods
Seventy-nine patients with gSMT who underwent surgical resection at our department between January 2004 and January 2023 were retrospectively assessed. LWR and LECS were performed in 61 and 18 patients, respectively. Clinicopathological features and short-term surgical outcomes were assessed between the 2 groups. A 2:1 propensity score matching was performed to mitigate the effects of selection biases. Regardless of the surgical procedure, all the patients underwent curative resection with negative margins.

Results
The LWR and LECS groups included 24 and 12 patients, respectively. The mean operative duration was significantly shorter in the LWR group than in the LECS group (LWR, 131.1 minutes; LECS, 195.2 minutes; P &lt; 0.05). The mean ratio of tumor diameter to resected specimen diameter was significantly higher in the LECS group than in the LWR group (LWR, 60.3%; LECS, 78.9%; P &lt; 0.05). The mean ratio of tumor area to resected specimen area was significantly higher in the LECS group than in the LWR group (LWR, 44.7%; LECS, 66.3%; P &lt; 0.05).

Conclusion
LECS was performed safely with a minimal and optimal safety margin compared with LWR. The findings suggest that LECS can be a feasible option for the treatment of gSMTs.
Substituent Effects on the Electrophilic Activity of Nitroarenes in Reactions with Carbanions
Authors: Błażej Sylwia , Mąkosza Mieczysław 
Published: December 2008

AbstractThe effect on electrophilic activity of substituents located para, ortho, and meta to the nitro group of nitrobenzenes was determined by using vicarious nucleophilic substitution of hydrogen (VNS) with the carbanion of chloromethyl phenyl sulfone (1) as the model process. Values for the relative activities of substituted nitroarenes are given relative to nitrobenzene, which was taken as the standard. This process was chosen as a model reaction because it meets key criteria, such as the wide range of substituents that can be present on the nitrobenzene ring, a low sensitivity to steric hindrance, and in particular the possibility of ensuring conditions in which the overall relative rates of reaction in competitive experiments are equal to the relative rates of nucleophilic addition. The values of relative rates of addition, which were taken to be a measure of electrophilic activity, were determined by competitive experiments in which pairs of nitroarenes competed for the VNS reaction with carbanion of 1. A comprehensive set of data for effects of substituents on the electrophilic activity of nitroarenes is presented for the first time.
Transmetalation Reactions from Fischer Carbene Complexes to Late Transition Metals: A DFT Study
Authors: Fernández Israel , Mancheño María J. , Vicente Rubén , López Luis A. , Sierra Miguel A. 
Published: December 2008

AbstractTransmetalation reactions from chromium(0) Fischer carbene complexes to late‐transition‐metal complexes (palladium(0), copper(I), and rhodium(I)) have been studied computationally by density functional theory. The computational data were compared with the available experimental data. In this study, the different reaction pathways involving the different metal atoms have been compared with each other in terms of their activation barriers and reaction energies. Although the reaction profiles for the transmetalation reactions to palladium and copper are quite similar, the computed energy values indicate that the process involving palladium as catalyst is more favorable than that involving copper. In contrast to these transformations, which occur via triangular heterobimetallic species, the transmetalation reaction to rhodium leads to a new heterobimetallic species in which a carbonyl ligand is also transferred from the Fischer carbene to the rhodium catalyst. Moreover, the structure and bonding situation of the so far elusive heterobimetallic complexes are briefly discussed.
Proper analysis of secondary phenotype data in case‐control association studies
Authors: Lin D. Y. , Zeng D. 
Published: December 2008

AbstractCase‐control association studies often collect extensive information on secondary phenotypes, which are quantitative or qualitative traits other than the case‐control status. Exploring secondary phenotypes can yield valuable insights into biological pathways and identify genetic variants influencing phenotypes of direct interest. All publications on secondary phenotypes have used standard statistical methods, such as least‐squares regression for quantitative traits. Because of unequal selection probabilities between cases and controls, the case‐control sample is not a random sample from the general population. As a result, standard statistical analysis of secondary phenotype data can be extremely misleading. Although one may avoid the sampling bias by analyzing cases and controls separately or by including the case‐control status as a covariate in the model, the associations between a secondary phenotype and a genetic variant in the case and control groups can be quite different from the association in the general population. In this article, we present novel statistical methods that properly reflect the case‐control sampling in the analysis of secondary phenotype data. The new methods provide unbiased estimation of genetic effects and accurate control of false‐positive rates while maximizing statistical power. We demonstrate the pitfalls of the standard methods and the advantages of the new methods both analytically and numerically. The relevant software is available at our website. Genet. Epidemiol. 2009. © 2008 Wiley‐Liss, Inc.
The limits of fine‐scale mapping
Authors: Smith Lucian P. , Kuhner Mary K. 
Published: December 2008

AbstractWhen a novel genetic trait arises in a population, it introduces a signal in the haplotype distribution of that population. Through recombination that signal's history becomes differentiated from the DNA distant to it, but remains similar to the DNA close by. Fine‐scale mapping techniques rely on this differentiation to pinpoint trait loci. In this study, we analyzed the differentiation itself to better understand how much information is available to these techniques. Simulated alleles on known recombinant coalescent trees show the upper limit for fine‐scale mapping. Varying characteristics of the population being studied increase or decrease this limit. The initial uncertainty in map position has the most direct influence on the final precision of the estimate, with wider initial areas resulting in wider final estimates, though the increase is sigmoidal rather than linear. The Θ of the trait (4Nμ) is also important, with lower values for Θ resulting in greater precision of trait placement up to a point—the increase is sigmoidal as Θ decreases. Collecting data from more individuals can increase precision, though only logarithmically with the total number of individuals, so that each added individual contributes less to the final precision. However, a case/control analysis has the potential to greatly increase the effective number of individuals, as the bulk of the information lies in the differential between affected and unaffected genotypes. If haplotypes are unknown due to incomplete penetrance, much information is lost, with more information lost the less indicative phenotype is of the underlying genotype. Genet. Epidemiol. 2009. © 2008 Wiley‐Liss, Inc.
p53 dependent cell‐cycle arrest triggered by chemotherapy in xenografted breast tumors
Authors: Varna Mariana , Lehmann‐Che Jacqueline , Turpin Elisabeth , Marangoni Elizabetha , El‐Bouchtaoui Morad , Jeanne Marion , Grigoriu Carmen , Ratajczak Philippe , Leboeuf Christophe , Plassa Louis‐François , Ferreira Irmine , Poupon Marie‐France , Janin Anne , de Thé Hugues , Bertheau Philippe 
Published: December 2008

AbstractThe major long‐term prognostic factor for breast cancer patients treated by first‐line chemotherapy is response to treatment. We have previously shown that complete responses to high doses epirubicin‐cyclophosphamide were observed only in human tumors bearing a TP53 mutation. Three xenografted human breast tumors, 2 of them with a TP53 mutation and one of them without, were studied for their immediate response to this drug association. Cell cycle, cellular senescence and cell death were characterized and quantified on tissue section before and after treatment. The TP53 wild‐type tumor showed a strong early induction of senescence‐like phenotype with overexpression of SA‐β‐gal and p21CIP1. In contrast both TP53 mutated tumors showed no sign of cell cycle arrest or senescence. Conversely, abnormal mitoses strongly increased, only in TP53 mutated tumors. Thus, in these in vivo models, epirubicin‐cyclophosphamide treatment induces senescence‐like features in TP53 wild‐type tumor, likely accounting for cell cycle arrest and subsequent resistance to treatment. Conversely in TP53 mutated tumors, chemotherapy induces mitotic catastrophe and tumor death, accounting for complete response to this association exclusively in patients with TP53 mutated tumors. © 2008 Wiley‐Liss, Inc.
PEGylation of brain‐derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution
Authors: Soderquist Ryan G. , Milligan Erin D. , Sloane Evan M. , Harrison Jacqueline A. , Douvas Klarika K. , Potter Joseph M. , Hughes Travis S. , Chavez Raymond A. , Johnson Kirk , Watkins Linda R. , Mahoney Melissa J. 
Published: December 2008

AbstractBrain‐derived neurotrophic factor (BDNF) was covalently attached to polyethylene glycol (PEG) in order to enhance delivery to the spinal cord via the cerebrospinal fluid (intrathecal administration). By varying reaction conditions, mixtures of BDNF covalently attached to one (primary), two (secondary), three (tertiary), or more (higher order) PEG molecules were produced. The biological activity of each resulting conjugate mixture was assessed with the goal of identifying a relationship between the number of PEG molecules attached to BDNF and biological activity. A high degree ofin vitrobiological activity was maintained in mixtures enriched in primary and secondary conjugate products, while a substantial reduction in biological activity was observed in mixtures with tertiary and higher order conjugates. When a biologically active mixture of PEG‐BDNF was administered intrathecally, it displayed a significantly improved half‐life in the cerebrospinal fluid and an enhanced penetration into spinal cord tissue relative to native BDNF. Results from these studies suggest a PEGylation strategy that preserves the biological activity of the protein while also improving the half‐life of the proteinin vivo. Furthermore, PEGylation may be a promising approach for enhancing intrathecal delivery of therapeutic proteins with potential for treating disease and injury in the spinal cord. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Superlubricious surface mimicking articular cartilage by grafting poly(2‐methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings
Authors: Kyomoto Masayuki , Moro Toru , Iwasaki Yasuhiko , Miyaji Fumiaki , Kawaguchi Hiroshi , Takatori Yoshio , Nakamura Kozo , Ishihara Kazuhiko 
Published: December 2008

AbstractAseptic loosening of the artificial hip joint with osteolysis due to the wear particles from polyethylene cup has remained as a serious issue. To reduce this wear and develop a novel artificial hip joint system, we produced a superlubricious metal‐bearing material: for this, we grafted a 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymer onto the surface of a cobalt–chromium–molybdenum (Co‐Cr‐Mo) alloy. For ensuring long‐term benefit retention of poly(MPC) on the Co‐Cr‐Mo alloy for application as a novel artificial hip joint system, several issues must be considered: strong bonding between poly(MPC) and Co‐Cr‐Mo surface, high mobility of free end groups of the poly(MPC) layer, and high density of the introduced poly(MPC). Considering these issues, we introduced a 3‐methacryloxypropyl trimethoxysilane (MPSi) intermediate layer and a photoinduced graft polymerization technique to create a strong covalent bond between the Co‐Cr‐Mo substrate and the poly(MPC) chain via the MPSi layer. The thickness and density of the poly(MPC) layer on the surface increased with the MPC concentration and photoirradiation time. The grafted poly(MPC) layer successfully provided super‐lubricity to the Co‐Cr‐Mo surface. The poly(MPC)‐grafted crosslinked polyethylene/poly(MPC)‐grafted Co‐Cr‐Mo or cartilage/poly(MPC)‐grafted Co‐Cr‐Mo bearing interface mimicking natural joints showed an extremely low friction coefficient of 0.01, which is as low as that of natural cartilage interface. A superlubricious metal‐bearing surface would enable the development of a novel biocompatible artificial hip joint system‐artificial femoral head for partial hemiarthroplasty and metal‐on‐polymer/metal type for total hip arthroplasty. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Strong alkalinization in the anterior midgut of larval yellow fever mosquitoes (Aedes aegypti): involvement of luminal Na+/K+‐ATPase
Authors: Onken Horst , Patel Malay , Javoroncov Margarita , Izeirovski Sejmir , Moffett Stacia B. , Moffett David F. 
Published: December 2008

AbstractRecently, Na+/K+‐ATPase has been detected in the luminal membrane of the anterior midgut of larval yellow fever mosquitoes (Aedes aegypti) with immunohistochemical techniques. In this study, the possible involvement of this ATPase in strong alkalinization was investigated on the level of whole larvae, isolated and perfused midgut preparations and on the molecular level of the Na+/K+‐ATPase protein. Ouabain (5 mM) did not inhibit the capability of intact larval mosquitoes to alkalinize their anterior midgut. Also in isolated and perfused midgut preparations the perfusion of the lumen with ouabain (5 mM) did not result in a significant change of the transepithelial voltage or the capacity of luminal alkalinization. Na+/K+‐ATPase activity was completely abolished when KCl was substituted with choline chloride, suggesting that the enzyme cannot act as an ATP‐driven Na+/H+‐exchanger. Altogether the results of the present investigation indicate that apical Na+/K+‐ATPase is not of direct importance for strong luminal alkalinization in the anterior midgut of larval yellow fever mosquitoes. J. Exp. Zool. 311A:155–161, 2009. © 2008 Wiley‐Liss, Inc.