bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Relapse of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in a Randomized Controlled Trial of Plasma Exchange and Glucocorticoids
Authors: Junek Mats L. , Merkel Peter A. , Vilayur Eswari , Wald Ron , Khalidi Nader , Jayne David , Walsh Michael ,   for the PEXIVAS Investigators
Published: March 2024

ObjectiveRelapses of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis are important events that can cause organ dysfunction and reduce quality of life. Understanding the effects of the initial treatments for ANCA‐associated vasculitis on the subsequent risk of relapse may help guide monitoring and treatment.MethodsWe performed a post hoc analysis of participants with severe ANCA‐associated vasculitis enrolled in an international two‐by‐two factorial randomized controlled trial comparing the effects of plasma exchange (PLEX) to no PLEX and a regimen of reduced glucocorticoid exposure to a standard regimen. We estimated the effects of treatments on relapses of any severity using three competing risk time‐to‐event models adjusted for patient and disease characteristics and other treatments. Each model was adjusted for disease manifestations in different ways.ResultsOf 704 participants, 649 (92.2%) achieved remission and 147 (22.7%) experienced 204 relapses. The relapse rate was 10.3 (95% confidence interval [CI] 8.4–12.1) relapses per 100 patient‐years. Neither the use of PLEX (subhazard ratio 0.91–0.94; 95% CIs range from 0.66 to 1.31) nor a glucocorticoid regimen (subhazard ratio 0.93–0.94; 95% CIs range from 0.67 to 1.35) appreciably changed the risk of relapse. Proteinase 3–ANCA and the presence of nonhemorrhagic respiratory manifestations of the disease at trial entry were associated with increased risks of relapse. Receiving dialysis at baseline and administration of oral cyclophosphamide as induction therapy were associated with lower risks of relapse.ConclusionIn patients with severe ANCA‐associated vasculitis, relapses remain common; neither the use of PLEX nor an initial glucocorticoid tapering regimen impacted relapse risk.
Metaknowledge of Experts Versus Nonexperts: Do Experts Know Better What They Do and Do Not Know?
Authors: Han Yuyan , Dunning David 
Published: March 2024

ABSTRACTExperts are usually valued for their knowledge. However, do they possess metaknowledge, that is, knowing how much they know as well as the limits of that knowledge? The current research examined expert metaknowledge by comparing experts' and nonexperts' confidence when they made correct versus incorrect choices as well as the difference in‐between (e.g., Murphy's Resolution and Yate's Separation). Across three fields of expertise (climate science, psychological statistics, and investment), we found that experts tended to display better metaknowledge than nonexperts but still showed systematic and important imperfections. They were less overconfident than nonexperts in general and expressed more confidence in their correct answers. However, they tend to exhibit low Murphy's Resolution similar to nonexperts and gave endorsed wrong answers with equal to higher confidence than did their nonexpert peers. Thus, it appears that expertise is associated with knowing with more certainty what one knows but conceals awareness of what one does not know.
An integrated conceptual model for enhancing refugee education
Authors: Miri Mir Abdullah 
Published: March 2024

AbstractThis paper introduces a unified conceptual framework for understanding refugee identity construction within educational contexts, drawing on theories of social justice (Fraser, 2008), affective relations (Lynch, 2012), the resumption of ordinary life (Kohli, 2011) and ecological systems (Bronfenbrenner, 1977). Addressing a gap in the existing scholarship, the model emphasises the importance of affective relations in shaping refugee identities in education alongside other factors. The study examines the macro constructs of redistribution, recognition, representation and relational affect, highlighting their impact on refugee children's educational experiences. Further, it considers the micro constructs of safety, sense of belonging and success in integration and attainment in educational environments. The constructs are examined across various levels of Bronfenbrenner's ecological system, demonstrating the complexity of refugees’ needs. This model aims to facilitate a holistic, justice‐oriented approach to refugee education, which is crucial given the rise in global displacement. The study has significant implications for refugee education research and policymaking, potentially informing targeted interventions and programmes that foster academic success, overall well‐being, and practice in refugee education.
Recent Progress in the Synthesis of α‐Hydroxy Carbonyl Compounds with ThDP‐dependent Carboligases
Authors: Dobiašová Hana , Jurkaš Valentina , Both Peter , Winkler Margit 
Published: March 2024

AbstractThiamine diphosphate (ThDP) dependent carboligases catalyze the formation of carbon‐carbon bonds. These enzymes are prominent biocatalysts for the production of valuable α‐hydroxy carbonyl compounds, which serve as key building blocks in the synthesis of various pharmaceuticals and fine chemicals. Carboligases act in selective manner to afford regio‐ and stereochemically defined products from simple starting materials. This review explores the catalytic prowess of carboligases for synthetic purposes and is aimed at providing a selection tool of enzymes for particular sets of substrates or desired products. The comprehensive overview encompasses structural insights, relationships of the currently known sequence space and practical applications with a focus on recent literature, showcasing carboligases as potent tools for sustainable and efficient synthesis.
Key Role of Water in Copper‐ and Base‐free Sonogashira Coupling in Ethanol with [{Pd(μ‐OH)Cl(IPr)}2] as a Highly Effective Precatalyst
Authors: Ostrowska Sylwia , Rogalski Szymon , Pietraszuk Cezary 
Published: March 2024

AbstractAryl bromides and 4‐chlorotoluene as an example aryl chloride in the presence of N‐heterocyclic carbene (NHC) palladium hydroxo dimers of the type [{Pd(μ‐OH)Cl(NHC)}2] (where NHC=IPr, SIPr, IMes, SIMes) undergo an efficient and selective Sonogashira cross‐coupling with (hetero)arylacetylenes. The procedure allows the high‐throughput and selective synthesis of a broad spectrum of 1,2‐diarylacetylenes using 10 ppm of [{Pd(μ‐OH)Cl(IPr)}2] as precatalyst. For the coupling of 4‐chlorotoluene with phenylacetylene, TON=560000 was achieved. Hydrogen chloride was observed as a product of the Sonogashira cross‐coupling reaction. The formation of the active Pd(0) from the Pd(II) complex was found to proceed via ethanol oxidation. Mechanistic studies showed that water plays a key role in the reaction.
Electron Transfer of Cellobiose Dehydrogenase in Polyethyleneimine Films
Authors: Karnpakdee Kwankao , Kracher Daniel , Ludwig Roland 
Published: March 2024

AbstractCellobiose dehydrogenase (CDH) is applied as a bioelectrocatalyst in biosensors because its mobile cytochrome domain is capable of direct electron transfer. This study investigates the electron transfer mechanism of CDH molecules embedded in the polycation polyethyleneimine (PEI), which has been reported as a current‐boosting component of CDH‐based biosensors. By immobilizing different concentrations of CDH and its isolated cytochrome domain in PEI films, we found that increasing concentrations of cytochrome enhanced the film conductivity (up to 251±8 mS cm−1) through improved electron transfer between the protein redox centers. The increased electrical conductivity of the film contacts CDH molecules at a greater distance from the electrode. The cross‐linker poly(ethylene glycol) diglycidyl ether improves the packing and contacting of the cytochrome domains, whereas glutaraldehyde reduces the current obtained. Deglycosylation of CDH enhances the conductivity of enzyme‐polymer films by up to 34 %, implying a higher number of productive electron‐hopping events between cytochrome domains due to enhanced mobility or reduced shielding. By balancing negative charges on the CDH surface at neutral and alkaline pH, PEI increases the interdomain electron transfer and the electrical film conductivity. The resulting increased current output is relevant for in vivo bioanalytical applications.
Design and Asymmetric Control of Orientational Chirality by Using the Combination of C(sp2)‐C(sp) Levers and Achiral N‐Protecting Group
Authors: Wang Yu , Xu Ting , Jin Shengzhou , Wang Jia‐Yin , Yuan Qingkai , Liu Hao , Tang Yao , Zhang Sai , Yan Wenxin , Jiao Yinchun , Li Guigen 
Published: March 2024

AbstractNew chiral targets of orientational chirality have been designed and asymmetrically synthesized by taking advantage of N‐sulfinyl imine‐directed nucleophilic addition/oxidation, Suzuki‐Miyaura, and Sonogashira cross‐coupling reactions. Orientation of single isomers has been selectively controlled by using aryl/alkynyl levers [C(sp2)‐C(sp) axis] and tBuSO2‐ protecting group on nitrogen as proven by X‐ray diffraction analysis. The key structural characteristic of resulting orientational products is shown by remote through‐space blocking manner. Seventeen examples of multi‐step synthesis were obtained with modest to good chemical yields and complete orientational selectivity.
Carbon and Nitrogen‐Co‐Doped Se/NiSe2/CoSe2 Nanocomposite as Superior Performance Electrode Material in Hybrid Supercapacitors
Authors: Mostafa Reham Ehab , Mahmoud S. S. , Tantawy N. S. , Mohamed Saad G. 
Published: March 2024

AbstractMetal selenides are essential electrode materials for promising electrochemical energy storage with comparable or improved electrochemical performance than metal oxides. Herein, Se/NiSe2/CoSe2 (S/NS/CS) is fabricated using a solvothermal approach with the assistance of polyethyleneimine, followed by annealing at different temperatures (300, 400, 500, and 600 °C) for one hour under an argon atmosphere. After annealing, all electrodes’ physical and electrochemical properties were examined, which determined that the best electrode is NiCo2O4/NiO (NCO/NO) formed at 500 °C. Additional hydrothermal method uses NCO/NO with SeO2 as a selenium source to prepare S/NS/CS nanocomposite, with a specific surface architecture that enables easy ion movement and robust conductivity, giving it exceptional electrochemical energy storage properties. It exhibited a remarkable capacitance of 468 F g−1 at a current density of 0.5 A g−1. For practical applications, the hybrid S/NS/CS//AC device was designed using S/NS/CS as a positive electrode and commercial activated carbon (AC) as a negative electrode. The asymmetric device demonstrated an excellent capacitance of 142 F g−1 (189 C g−1) and a superb specific energy of 44 Wh kg−1 at a specific power of 840 W kg−1 at a current density of 1 A g−1, providing 80 % capacity retention and 100 % coulombic efficiency after 5000 cycles.
A detailed study of the current‐reuse VCO's operation and a simple circuit technique to generate intrinsic‐balanced outputs
Authors: Jafari Bahram , Sheikhaei Samad 
Published: March 2024

SummaryIn the first part of this paper, we closely examine well‐known methods for balancing the output power level of the pseudo‐differential current‐reuse voltage‐controlled oscillator. We scrutinize their effectiveness in terms of canceling output mismatches, insensitivity to process, voltage, and temperature variations, and their capability of not degrading phase noise performance. Through analyses and simulations, it is shown that contrary to common belief, some techniques are not as effective as previously thought and should be employed only under specific circumstances. The best conventional approach is proven to be the use of a common‐mode shunting capacitor at the inductor's center tap node to create a virtual ground. In the second part, it is demonstrated that the current‐reuse voltage‐controlled oscillator can intrinsically produce balanced outputs without using any additional techniques or extra passive or active components. Using single‐ended tank capacitors instead of differential ones, the common‐mode voltage of the outputs is shunted to the real ground. This technique reintroduces a reference voltage to the tank circuit, forcing the oscillator to achieve equilibrium between positive and negative swings. The proposed current‐reuse oscillator is designed and post‐layout simulated in a 65‐nm CMOS process, covering a frequency range of 4.84–6.38 GHz with an average power consumption of 0.65 mW. It produces balanced outputs with an amplitude error of less than ±0.2% and achieves a phase noise of −126.7 dBc/Hz and FoMT of 201.8 dB at a 3‐MHz offset frequency.
A multi‐objective optimization approach for modeling and analyzing the impact of drive parameters in SiC power converters
Authors: Liu Xinbo , Liu Bo , He Shuiyuan , Ma Ruiqi , Diao Lijun 
Published: March 2024

SummaryThis paper introduces an equivalent model including the parasitic parameters analysis of silicon carbide (SiC) MOSFETs in order to enhance their performance for high‐power density applications. The model is used to establish a mechanism that evaluates the effect of drive parameters on switching losses and electrical stress of power devices, providing a theoretical basis for optimizing the design of drive parameters. The paper finds the Pareto solution of the multi‐objective optimization model through iterative calculation of design variables, using this mechanism. The methodology is validated through experimental results from an SiC power prototype, showing an efficiency of 98.9% and safe electrical stress levels under 1500 V/100 kW operating conditions.
Positive‐to‐negative tunable delay circuit designed with NGD RC network
Authors: Junwen Shi , Junyan Cui , Silochi Hakim Epea , Wieser Robert , Galan Raul Sanchez , Murad Nour Mohammad , Ravelo Blaise 
Published: March 2024

SummaryDespite the performed progressive research work, the interpretation of the negative group delay (NGD) function remains not familiar to non‐specialist design and fabrication circuit engineers. The functionality misunderstanding limits the NGD circuit applications compared to other classical electronic functions. The present paper deals with the design of a tunable circuit by operating with positive and negative delay behaviors. The topology of the tunable circuit by using a low‐pass (LP) type NGD circuit is described. The design formulas for calculating the circuit resistor and capacitor parameters from the desired delay are expressed. The design feasibility of the tunable circuit composed of LP‐NGD cell and RC‐circuit is validated with a proof‐of‐concept (PoC) implemented on a test board. Two different signals with pulse and arbitrary waveforms having tens‐milliseconds duration were considered during the validation tests. As expected by tuning a varistor from 0.4 kΩ to 1 kΩ, the negative delay behavior varying from about −0.4 ms was verified thanks to the time‐advanced effect due to the LP‐NGD property. Then, the output signal delay was observed to become positive when the varistor was tuned from 1 kΩ to 3 kΩ.
Strong philopatry in an estuarine‐dependent fish
Authors: Sarakinis Koster G. , Reis‐Santos Patrick , Donnellan Stephen C. , Ye Qifeng , Earl Jason , Gillanders Bronwyn M. 
Published: March 2024

AbstractUnderstanding fish movement is critical in determining the spatial scales in which to appropriately manage wild populations. Genetic markers provide a natural tagging approach to assess the degree of gene flow and population connectivity across a species distribution. We investigated the genetic structure of black bream Acanthopagrus butcheri across its entire distribution range in Australia, as well as regional scale gene flow across south‐eastern Australia by undertaking a comprehensive analysis of the populations in estuaries across the region. We applied genome‐wide sampling of single‐nucleotide polymorphism (SNP) markers generated from restriction site‐associated DNA sequencing. Genetic structure and potential gene flow was assessed using principal component analyses and admixture analyses (STRUCTURE). Using 33,493 SNPs, we detected broad scale genetic structuring, with limited gene flow among regional clusters (i.e. Western Australia, South Australia and western Victoria; and eastern Victoria, Tasmania and New South Wales). This is likely the result of unsuitable habitats, strong ocean currents (e.g. the Leeuwin Current and the East Australian Current), large water bodies (e.g. Bass Strait) and known biogeographical provinces across the continent. Local‐scale genetic structuring was also identified across the south‐eastern Australian estuaries sampled, reflecting that the coexistence of both migratory and resident individuals within populations (i.e. partial migration), and the movement of fish into coastal waters, still results in strong philopatry across the region. Instances of movement among estuaries at this spatial scale were primarily found between adjacent estuaries and were likely attributed to lone migrants utilising inshore coastal currents for movement beyond nearby habitats. Targeting SNP markers in A. butcheri at this continental scale highlighted how neither spatial proximity of estuaries nor black bream's ability to move into coastal waters reflects increased gene flow. Overall, our findings highlight the importance of location‐specific management.
Roegneria yenchiana: A new species in the Triticeae (Poaceae) from the Hengduan Mountain region
Authors: Sha Li‐Na , Liang Xiao , Zhang Xin‐Yi , Gao Shan , Zhang Yue , Zhou Yong‐Hong , Fan Xing 
Published: March 2024

AbstractRoegneria yenchianasp. nov. (Triticeae) is a new species collected from Shangri‐la of Yunnan Province in China based on morphological, cytological, and molecular data. It is morphologically characterized by one spikelet per node, rectangular glums, awns flanked by two short mucros in lemmas, distinguished from other species ofRoegneria. The genomic in situ hybridization results indicate thatR. yenchianais an allotetraploid, and its genomic constitution isStY. Phylogenetic analyses based on multiple loci suggested thatR. yenchianais closely related toPseudoroegneriaandRoegneria,and thePseudoroegneriaserved as the maternal donors during its polyploid speciation.
Spatial extent drives patterns of relative climate change sensitivity for freshwater fishes of the United States
Authors: Silknetter Samuel C. , Benson Abigail L. , Smith Jennifer A. , Mims Meryl C. 
Published: March 2024

AbstractAssessing the sensitivity of freshwater species to climate change is an essential component of prioritizing conservation efforts for threatened freshwater ecosystems and organisms. Sensitivity to climate change can be systematically evaluated for multiple species using geographic attributes such as range size and climate niche breadth, and using species traits associated with climate change sensitivity. These systematic evaluations produce relative rankings of species sensitivity to aid conservation prioritization and to identify relatively sensitive species that may otherwise be understudied or overlooked. Due in part to biogeographic constraints, species assemblages change across regions and spatial extents; yet, the degree to which spatial factors influence relative rankings of species sensitivity is unclear. The spatial extent of multispecies analyses may alter relative rankings of species climate sensitivity; alternatively, relative climate sensitivity may be conserved among spatial scales, resulting in consistent identification of sensitive species among regions and spatial extents. We investigated how spatial extent influences our understanding of relative climate sensitivity for 137 native freshwater fishes of the United States that were representative of taxonomic, trait, and geographic diversity. Using publicly available occurrence data from the Global Biodiversity Information Facility, we calculated a systematic, geographically derived index of climate change sensitivity for study species at national and regional extents, including within four major hydrologic subregions of the United States. We examined the effects of spatial extent on the relative ranking of climate sensitivity among species, and we explored relationships among climate sensitivity, species traits, and conservation status at regional and national extents. We found that climate sensitivity rankings of species were influenced by spatial extent in some specific instances, but that relative rankings were largely conserved across spatial scales. However, correlations among geographically derived climate sensitivity rankings and species traits associated with climate sensitivity were variable across scales and regions, suggesting that links between geographic rarity and species traits may be scale‐dependent in some cases. Finally, we found few associations between climate sensitivity and current conservation status among species. Systematic approaches to quantifying climate sensitivity may offer an opportunity to identify sensitive but overlooked species for pre‐listing actions such as monitoring or conservation agreements.
Incomplete lipid extraction as a possible cause for underestimation of lipid oxidation in emulsions
Authors: Münch Katharina , ten Klooster Sten , van Kouwen Isabelle , Berton‐Carabin Claire , Schroën Karin 
Published: March 2024

AbstractLipid oxidation deteriorates the sensory and nutritional quality of food emulsions containing polyunsaturated fatty acids. Classically, different extraction solvents are used as a first step to measure lipid oxidation in emulsions. However, it is unclear how the applied extraction method influences the measured lipid oxidation values. In this work, we systematically examined the performance of common solvent mixtures such as chloroform, methanol, and hexane (or isooctane)–isopropanol on lipid extraction from emulsions stabilized with different emulsifiers (Tween 20 (T20), whey proteins, and pea proteins) and oxidation levels, and how this, in turn, affected the measured hydroperoxide concentrations. Chloroform–methanol was the most effective solvent (lipid yield >93 wt.%). When using hexane–isopropanol, extraction yields were consistently high for T20‐ and pea protein‐based emulsions (>60 wt.%), but in whey protein‐based emulsions, values as low as 26 wt.% were measured. In case of incomplete extraction, hydroperoxide concentrations measured by colorimetric methods need to be corrected for this effect. When using 1H NMR to assess lipid oxidation, the actual amount of extracted lipids is intrinsically taken into account. This highlights not only the importance of the extraction method in determining lipid oxidation in emulsions but also that of the actual analysis method.Practical application: This study highlights that the lipid extraction yield can vary depending not only on the emulsion composition (e.g., type of emulsifier) but also on the oxidative state of the emulsion and the extraction solvent used. If this is overlooked, errors can be made in the hydroperoxide determination. Although these effects can be corrected for, this is not standard procedure, which implies that awareness on this matter should be increased. It is also important to point out that depending on the solvent used, the different lipid classes (including various lipid oxidation products) may be extracted at different levels. Chloroform–methanol should be preferred for extraction of all lipid and lipid oxidation‐derived molecules, including aldehydes.