bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
Authors: Pal Sumanta K. , Tran Ben , Haanen John B.A.G. , Hurwitz Michael E. , Sacher Adrian , Tannir Nizar M. , Budde Lihua E. , Harrison Simon J. , Klobuch Sebastian , Patel Sagar S. , Meza Luis , Dequeant Mary-Lee , Ma Anna , He Qiuling Ally , Williams Leah M. , Keegan Alissa , Gurary Ellen B. , Dar Henia , Karnik Sushant , Guo Changan , Heath Heidi , Yuen Rachel R. , Morrow Phuong K. , Agarwal Neeraj , Srour Samer A. 
Published: April 2024

Abstract
Therapeutic approaches for clear cell renal cell carcinoma (ccRCC) remain limited; however, chimeric antigen receptor (CAR) T-cell therapies may offer novel treatment options. CTX130, an allogeneic CD70-targeting CAR T-cell product, was developed for the treatment of advanced or refractory ccRCC. We report that CTX130 showed favorable preclinical proliferation and cytotoxicity profiles and completely regressed RCC xenograft tumors. We also report results from 16 patients with relapsed/refractory ccRCC who received CTX130 in a phase I, multicenter, first-in-human clinical trial. No patients encountered dose-limiting toxicity, and disease control was achieved in 81.3% of patients. One patient remains in a durable complete response at 3 years. Finally, we report on a next-generation CAR T construct, CTX131, in which synergistic potency edits to CTX130 confer improved expansion and efficacy in preclinical studies. These data represent a proof of concept for the treatment of ccRCC and other CD70+ malignancies with CD70− targeted allogeneic CAR T cells.
Significance: Although the role of CAR T cells is well established in hematologic malignancies, the clinical experience in solid tumors has been disappointing. This clinical trial demonstrates the first complete response in a patient with RCC, reinforcing the potential benefit of CAR T cells in the treatment of solid tumors.
See corresponding author Sumanta K. Pal discuss this research article, published simultaneously at the AACR Annual Meeting 2024: https://vimeo.com/932606570/887520f9cb
Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic: The PRO-HF Trial
Authors: Sandhu Alexander T. , Calma Jamie , Skye Megan , Kalwani Neil , Zheng Jimmy , Schirmer Jessica , Din Natasha , Brown Johnson Cati , Gupta Anshal , Lan Roy , Yu Brian , Spertus John A. , Heidenreich Paul A. 
Published: April 2024

BACKGROUND:
The impact of routine clinic use of patient-reported outcome (PRO) measures on clinical outcomes in patients with heart failure (HF) has not been well-characterized. We tested if clinic-based use of a disease-specific PRO improves patient-reported quality of life at 1 year.

METHODS:
The PRO-HF trial (Patient-Reported Outcome Measurement in Heart Failure Clinic) was an open-label, parallel, patient-level randomized clinical trial of routine PRO assessment or usual care at an academic HF clinic between August 30, 2021, and June 30, 2022, with 1 year of follow-up. In the PRO assessment arm, participants completed the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) at each HF clinic visit, and results were shared with their treating clinician. The usual care arm completed the KCCQ-12 at randomization and 1 year later, which was not shared with the treating clinician. The primary outcome was the KCCQ-12 overall summary score (OSS) between 12 and 15 months after randomization. Secondary outcomes included domains of the KCCQ-12, hospitalization and emergency department visit rates, HF medication therapy, clinic visit frequency, and testing rates.

RESULTS:

Across 17 clinicians, 1248 participants were enrolled and randomized to PRO assessment (n=624) or usual care (n=624). The median age was 63.9 years (interquartile range [IQR], 51.8–72.8), 38.9% were women, and the median baseline KCCQ-12 OSS was 82.3 (IQR, 58.3–94.8). Final KCCQ-12 (available in 87.9% of the PRO arm and 85.1% in usual care;
P
=0.16) median OSS were 87.5 (IQR, 68.8–96.9) in the PRO arm and 87.6 (IQR, 69.7–96.9) in the usual care arm with a baseline-adjusted mean difference of 0.2 ([95% CI, −1.7 to 2.0];
P
=0.85). The results were consistent across prespecified subgroups. A post hoc analysis demonstrated a significant interaction with greater benefit among participants with a baseline KCCQ-12 OSS of 60 to 80 but not in less or more symptomatic participants. No significant differences were found in 1-year mortality, hospitalizations, emergency department visits, medication therapy, clinic follow-up, or testing rates between arms.

CONCLUSIONS:
Routine PRO assessment in HF clinic visits did not impact patient-reported quality of life or other clinical outcomes. Alternate strategies and settings for embedding PROs into routine clinical care should be tested.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04164004.
The Politics and Aesthetics of Liberation: Revolution and Its Aftermath in Contemporary Artistic Practice from and about Lusophone Africa
Authors: Balona de Oliveira Ana 
Published: April 2024

Abstract
This essay explores the ways in which artistic practices have revisited histories and memories of anti-colonial struggle, socialist revolution, and decolonization in Mozambique, Angola, Guinea-Bissau, and Portugal, while also addressing apartheid South Africa and the global Cold War. The cartography drawn here follows the histories and geographies of anti-colonial and anti-apartheid friendship without losing sight of several forms of imperialism, old and new. This essay examines the archival and historiographical potential of contemporary art in remembering histories of revolution and decolonization, notably those pertaining to cultural production and especially film, in the globalized, neoliberal present. My case studies are distinct but related works by Ângela Ferreira (Mozambique, 1958), Filipa César (Portugal, 1975), and Kiluanji Kia Henda (Angola, 1979), which include installation, video, photography, and performance for the camera. What sort of insights do the archival imaginations of pasts, presents and futures at play in these works offer? And how far can the ethics and politics of their aesthetics go?
Analysis of Anxiety, Subjective Well-being, and Quality of Life of Medical Students during COVID-19 Lockdown in Erode, Tamil Nadu: A Cross-Sectional Study
Authors: Vijayalakshmi I. , Niruba R. , Subha K. C. , Periasamy Panneerselvam , Mathivadhana Andamuthu Vetrivel , Gunasekaran Sasikala 
Published: April 2024

Background: A novel COVID-19 has spread worldwide and created a big threat for the public and their daily life. Due to its rapid transmission and the mortality rate, governments across the world had created many restrictions such as social isolation which leads to economic crisis that also leads to the source of fear, stress, anxiety, and mood conditions and negatively affects people’s mental health (Praveen et al., 2021). Although the initiatives were prepared, the coronavirus may also cause mental defects. These defects also affected the medical students, since they were the backbone and the future of public health, hence the study would describe the quality of well-being by different domains. Materials and Methods: The study was designed by the questionnaire based on the World Health Organization Quality of life-BREL, Subjective Well-Being Inventory (SWBI), and Beck Anxiety Inventory (BAI) research tool. A total of 288 students were participated in the study. Results: A total of 288 medical students were participated in the study, according Cronbach Alpha method, all three domains had obtained a value of above 0.7, and the descriptive analysis showed the highest score of about 67.12 with physical activity. According to the BAI, 84% of medical students with low anxiety, the study also investigates the quality of well-being and compared with gender, with religion, with family type, place of living, religions, and among family’s monthly income. The results of the study were statistically defined, and it has a significant relationship with environment and SWBI. Conclusion: The quality of well-being was assessed on medical students and the study revealed that there is no impact with gender, religion, year of study, and family’s monthly income. Although the study also revealed that the mean score of social well-being is high with physical activity and considerably low with psychological and environmental activity.
Comparison of American College of Cardiology/American Heart Association Cardiovascular Risk Score, Framingham Risk Scores, European Society of Cardiology Cardiovascular Disease Risk Calculator, QRISK3-2018 Risk Calculator in Patients Presenting with First Time with Myocardial Infarction: A Step toward the Development of Indian Cardiac Risk Score
Authors: Solanki Nishita Devang , Pandya Tejas Rajendarkumar , Rathod Jaydeep , Rathod Vani , Panchal Krisha , Rana Devang Ashwinkumar 
Published: April 2024

Introduction: One of the primary reasons for fatalities and impairments on a global scale is cardiovascular disease (CVD), encompassing a cluster of illnesses impacting the heart and blood vessels. A CVD risk assessment is a screening tool that measures an individual’s risk of developing CVD. Objective: The objective of this study was to compare and evaluate cardiovascular risk using internationally recognized CVD risk scoring systems. Methodology: A prospective, cross-sectional study was carried out for 2 months after the approval of the ethics committee. Naive myocardial infarction (MI) patients presenting to the cardiology department and conforming to the inclusion criteria were enrolled in the study. Patients who are taking statins or any lipid-lowering drugs, as well as patients who are on low-dose aspirin and antidiabetic medications. Using the aforementioned gathered data, the cardiovascular risk scores were computed employing the American College of Cardiology/American Heart Association (ACC/AHA), Framingham risk scores (FRS), European Society of Cardiology (ESC) – CVD risk calculator, and QRISK→3-2018, and subsequently categorized as low risk, intermediate, or high risk based on the individual risk scores. Results: We enrolled 42 patients, with a mean age of 60 years with male dominance. The mean body mass index was 25.5. With a cholesterol/high-density lipoprotein (HDL) ratio of 4.9, the mean systolic blood pressure/diastolic blood pressure was 126/77 mm of Hg. The mean ACC/AHA cardiovascular risk score for 10-year atherosclerotic cardiovascular disease (ASCVD) risk was 11.34%, FRS mean score was 12%, ESC CVD risk calculator mean score was 15.45%, and QRISK3-2018 risk calculator mean score was 20.87% in patients presenting with first time with MI. Conclusion: QRISK3-2018 risk calculator is the most effective out of all the risk calculators with a maximum detection rate of MI in first time presented patients with Naïve MI patients.
25(OH) Vitamin D Status among Females with Preeclampsia/Eclampsia: A Long-term Plight Readdressed
Authors: Nagarajan Sruthi 
Published: April 2024

Background: Preeclampsia is a life-threatening multisystem disorder of pregnancy which has been observed in 2%–10% of pregnancies. The prevalence of Vitamin D deficiency ranges from 15% to 80%. Deficiency of Vitamin D is associated with the development of preeclampsia. This study was done to find out the prevalence of Vitamin D deficiency among preeclamptic/eclamptic and normal pregnant females, to establish Vitamin D deficiency as a causal factor of preeclampsia, and to elucidate the relation between 25 (OH) Vitamin D status and the severe preeclampsia. Materials and Methods: Blood samples were collected from 50 normotensives (controls) and 50 hypertensive pregnant females with preeclampsia/eclampsia (cases), and 25 (OH) Vitamin D level was measured by chemiluminescence Immunoassay. Results: Among the preeclamptic/eclamptic group, 32 (64%) were noted with Vitamin D deficiency and 18 (36%) with Vitamin D insufficiency. In the control group, 30 (60%) pregnant women showed Vitamin D deficiency, 19 (38%) with Vitamin D insufficiency, and a sufficient level of Vitamin D was observed in one woman (2%). Conclusion: Although it is difficult to demonstrate the correlation between Vitamin D levels and preeclampsia, there is a widespread global prevalence of Vitamin D deficiency during pregnancy. Hence, Vitamin D supplementation can be included routinely in the antenatal care program in India.
Rapidly Progressive Renal Failure in Young Adult: An Atypical Presentation of Multiple Myeloma - A Case Report
Authors: Goswami Himanish , Das Tonmoy , Bora Mitul , Kakoti Sweety , Hazarika Tanurekha , Choudhury Dhruvajyoti , Medhi Pranab , Bordoloi Zenila , Dutta Madhurima , Choudhury Sangeeta 
Published: April 2024

Introduction: Patients frequently present with renal impairment that does not fit the criteria for acute kidney injury or chronic kidney disease. This condition, known as rapidly progressive renal failure (RPRF), encompasses a diverse range of clinical syndromes characterized by the progressive renal impairment over days to weeks. Case Report: We present a case of a 37-year-old male with a short history of uremic symptoms and decreased urine output with no significant history or examination findings except pallor. The patient had a creatinine of 1.6 mg/dL in April 2022, rising to 4.4 mg/dL, then 11.6 mg/dL during May, 17.6 mg/dL in June, presented to us with a creatinine of 24.6 mg/dL, with normal kidney size and corticomedullary differentiation (CMD). Beta-2-microglobulin was elevated, and renal biopsy showed features suggestive of multiple myeloma (MM). Atypical appearing tubular casts showing 3+ patternless staining for kappa light chains and negativity for lambda light chains were observed. The patient was started on chemotherapy for MM, and renal function was gradually improving. Conclusion: Renal failure as the sole presentation of MM is rare, especially in young adults. This case emphasizes an atypical RPRF, particularly given the patient’s young age.
Digital Twin Technology of Human–Machine Integration in Cross-Belt Sorting System
Authors: Qu Yanbo , Zhao Ning , Zhang Haojue 
Published: April 2024

AbstractThe Chinese express delivery industry processes nearly 110 billion items in 2022, averaging an annual growth rate of 200%. Among the various types of sorting systems used for handling express items, cross-belt sorting systems stand out as the most crucial. However, despite their high degree of automation, the workload for operators has intensified owing to the surging volume of express items. In the era of Industry 5.0, it is imperative to adopt new technologies that not only enhance worker welfare but also improve the efficiency of cross-belt systems. Striking a balance between efficiency in handling express items and operator well-being is challenging. Digital twin technology offers a promising solution in this respect. A realization method of a human–machine integrated digital twin is proposed in this study, enabling the interaction of biological human bodies, virtual human bodies, virtual equipment, and logistics equipment in a closed loop, thus setting an operating framework. Key technologies in the proposed framework include a collection of heterogeneous data from multiple sources, construction of the relationship between operator fatigue and operation efficiency based on physiological measurements, virtual model construction, and an online optimization module based on real-time simulation. The feasibility of the proposed method was verified in an express distribution center.
Characterization and Analysis of Inconel 718 Alloy Ground at Different Speeds
Authors: Liu Hao , Han Huili , Jiang Qinghong , He Minglin , Zhang Bi 
Published: April 2024

AbstractInconel 718 (IN718) alloy is widely applied to fabricate high temperature resistant or corrosion resistant parts due to its excellent mechanical performance. However, the machining of IN718 alloy is difficult as it may cause serious tool wear and poor surface quality (SQ) of the workpiece. In this work, grinding experiments on IN718 alloy at different speeds were conducted by using a CBN grinding wheel. The relationship between grinding speed, SQ and subsurface damage (SSD) was well studied. With increasing grinding speed, surface roughness decreased, and SQ was greatly improved. Meanwhile, the microhardness of the grinding surface declined as the grinding speed increased. The SSD depth was almost unchanged when the grinding speed was lower than 15 m/s, then it decreased with higher grinding speeds. It was attributed to the mechanical-thermal synergistic effect in the grinding process. The results indicated that increasing grinding speed can effectively improve the SQ and reduce the SSD of IN718 alloy. The conclusion in the work may also provide insight into processing other hard-to-machining materials.
Alterations of the alpha rhythm in visual snow syndrome: a case-control study
Authors: Klein Antonia , Aeschlimann Sarah A. , Zubler Frederic , Scutelnic Adrian , Riederer Franz , Ertl Matthias , Schankin Christoph J. 
Published: April 2024

Abstract
Background
Visual snow syndrome is a disorder characterized by the combination of typical perceptual disturbances. The clinical picture suggests an impairment of visual filtering mechanisms and might involve primary and secondary visual brain areas, as well as higher-order attentional networks. On the level of cortical oscillations, the alpha rhythm is a prominent EEG pattern that is involved in the prioritisation of visual information. It can be regarded as a correlate of inhibitory modulation within the visual network.

Methods
Twenty-one patients with visual snow syndrome were compared to 21 controls matched for age, sex, and migraine. We analysed the resting-state alpha rhythm by identifying the individual alpha peak frequency using a Fast Fourier Transform and then calculating the power spectral density around the individual alpha peak (+/- 1 Hz). We anticipated a reduced power spectral density in the alpha band over the primary visual cortex in participants with visual snow syndrome.

Results
There were no significant differences in the power spectral density in the alpha band over the occipital electrodes (O1 and O2), leading to the rejection of our primary hypothesis. However, the power spectral density in the alpha band was significantly reduced over temporal and parietal electrodes. There was also a trend towards increased individual alpha peak frequency in the subgroup of participants without comorbid migraine.

Conclusions
Our main finding was a decreased power spectral density in the alpha band over parietal and temporal brain regions corresponding to areas of the secondary visual cortex. These findings complement previous functional and structural imaging data at a electrophysiological level. They underscore the involvement of higher-order visual brain areas, and potentially reflect a disturbance in inhibitory top-down modulation. The alpha rhythm alterations might represent a novel target for specific neuromodulation.

Trial registration
we preregistered the study before preprocessing and data analysis on the platform osf.org (DOI: https://doi.org/10.17605/OSF.IO/XPQHF, date of registration: November 19th 2022).

Graphical Abstract
Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA–miRNA/protein axis
Authors: Ci Yuan , Zhang Yuan , Zhang Xiaobo 
Published: April 2024

Abstract
Background
Long noncoding RNAs (lncRNAs) play essential roles in the tumorigenesis of gastric cancer. However, the influence of lncRNA methylation on gastric cancer stem cells (GCSCs) remains unclear.

Methods
The N6-methyladenosine (m6A) levels of lncRNAs in gastric cancer stem cells were detected by methylated RNA immunoprecipitation sequencing (MeRIP-seq), and the results were validated by MeRIP-quantitative polymerase chain reaction (qPCR). Specific sites of m6A modification on lncRNAs were detected by single-base elongation- and ligation-based qPCR amplification (SELECT). By constructing and transfecting the plasmid expressing methyltransferase-like 3 (METTL3) fused with catalytically inactivated Cas13 (dCas13b) and guide RNA targeting specific methylation sites of lncRNAs, we obtained gastric cancer stem cells with site-specific methylation of lncRNAs. Reverse transcription (RT)-qPCR and Western blot were used for detecting the stemness of treated gastric cancer stem cells.

Results
The site-specific methylation of PSMA3-AS1 and MIR22HG suppressed apoptosis and promoted stemness of GCSCs. LncRNA methylation enhanced the stability of PSMA3-AS1 and MIR22HG to suppress apoptosis of GCSCs via the PSMA3-AS1–miR-411-3p– or MIR22HG–miR-24-3p–SERTAD1 axis. Simultaneously, the methylated lncRNAs promoted the interaction between PSMA3-AS1 and the EEF1A1 protein or MIR22HG and the LRPPRC protein, stabilizing the proteins and leading to the suppression of apoptosis. The in vivo data revealed that the methylated PSMA3-AS1 and MIR22HG triggered tumorigenesis of GCSCs.

Conclusions
Our study revealed the requirement for site-specific methylation of lncRNAs in the tumorigenesis of GCSCs, contributing novel insights into cancer development.