bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of laminin peptide gradient in enzymatically cross‐linked collagen scaffolds on neurite growth
Authors: Yao Li , Damodaran Gopinath , Nikolskaya Natalia , Gorman Adrienne M. , Windebank Anthony , Pandit Abhay 
Published: February 2009

AbstractGuided neurite growth is critical in both peripheral nervous system and central nervous system nerve regeneration. Scaffolds that provide structural and guidance cues for neuronal cells have a potential role in neural regeneration application. Type I collagen is suitable to be processed as an engineered scaffold for nerve regeneration because of its biological and structural properties. A few previous studies have shown that cross‐linking of collagen scaffolds with microbial transglutaminase improves the mechanical strength and degradation properties of the scaffolds. It was shown that laminin 5 can regulate neurite outgrowth and extension. A motif (PPFLMLLKGSTR) in the human laminin 5 α3 chain is crucial for both integrin α3β1 receptor binding and cell adhesion. In the present work, we studied the guidance effect of a laminin peptide (PPFLMLLKGSTR) gradient in collagen and cross‐linked collagen scaffolds on neurite growth. Neurites of rat pheochromocytoma (PC12) cells showed a preferential growth toward the high laminin concentration level on the collagen scaffold, while the incorporation of laminin peptide in the scaffold did not influence neurite length of PC12 cells. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Fabrication of permeable tubular constructs from chemically modified chitosan with enhanced antithrombogenic property
Authors: Qiu Yongzhi , Zhang Ning , Kang Qian , An Yuehuei , Wen Xuejun 
Published: February 2009

AbstractThe failure of artificial vascular grafts in small diameter vessel replacement is mainly due to the early formation of thrombosis. To prevent the occurrence of thrombosis, much effort has been focused on developing an anti‐thrombogenic coating of synthetic vascular prostheses or artificial conduits with improved anti‐thrombogenic properties. Because surface coatings may be unstable for long‐term applications, a bulk material with anti‐thrombogenic property is desirable for the fabrication of vascular grafts or conduits. To this end, we have chemically modified chitosan by phthalization to derive an anti‐thrombogenic material for the fabrication of vascular grafts. The chemical structure of phthalized chitosan was characterized with infrared spectroscopy. The hydrophilicity was examined with contact angle measurement, and the molecular weight distribution was measured using gel permeation chromatography (GPC). Protein adsorption, hemolysis, and platelet adhesion assays were used to confirm the enhanced anti‐thrombogenic properties of this phthalized chitosan. Cytotoxicity and proliferation assays were performed to test its high biocompatibility. With its improved solubility and processibility, this phthalized chitosan was fabricated into selective permeable tubular constructs of varying sizes and morphology through a wet phase‐inversion process. With improved anti‐thrombogenic property, biocompatibility, and great processibility, phthalized chitosan has great potential as the material for the fabrication of small diameter vascular grafts. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Fluorous biphase oxidation of ethyl benzene and benzyl alcohol catalyzed by perfluoroalkyl phthalocyanine complexes
Authors: Qiu Tao , Xu Xiaoyong , Qian Xuhong 
Published: February 2009

AbstractBACKGROUND: Ketones and aldehydes are important organic chemicals as intermediates for the pharmaceutical and fine‐chemical industries. The existing oxidation reactions to obtain ketones and aldehydes are no longer sustainable because of the large amount of waste generated and use of stoichiometric reagents: a cleaner catalytic oxidation system needs to be developed.RESULTS: The experimental results show that cobalt (II) tetra‐(perfluorohexyl) phthalocyaninate delivered a high catalytic activity for the oxidation of ethyl benzene (35% conversion and 86% selectivity to acetophenone) at 90 °C under ambient pressure of oxygen. The catalyst could be recycled for at least four runs. For the oxidation of benzyl alcohol to benzaldehyde, a conversion of 6% was achieved but with a selectivity of 100% at 90 °C under 2 × 105 Pa O2.CONCLUSION: Perfluoroalkyl metallophthalocyanines can be used for the fluorous biphasic oxidation of ethyl benzene and benzyl alcohol with molecular oxygen. The cobalt (II) tetra‐(perfluorohexyl) phthalocyaninate exhibited the highest catalytic activity for the oxidation of ethyl benzene. The catalytic oxidation of benzyl alcohol using our method may be feasible in industrial applications. Copyright © 2009 Society of Chemical Industry
Benzoylpyruvates in heterocyclic chemistry
Authors: Nolsöe Jens M. J. , Weigelt Dirk 
Published: February 2009

Abstract
magnified imageThe present review covers the utility of benzoylpyruvates as a vehicle for the preparation of highly functionalized heterocycles. Regio‐ and chemoselective features are discussed with reference to the application of different nucleophilic species. In this context, the preparation of such rings as pyrazoles, isoxazoles, primidines, and pyridines are presented. As the means to establish a distinct functional pattern, the rendered strategy can be seen as an alternative to cross‐coupling protocols. J. Heterocyclic Chem., (2009).
DBU‐catalyzed three‐component one‐pot synthesis of highly functionalized pyridines in aqueous ethanol
Authors: Mamgain Ritu , Singh Ram , Rawat Diwan S. 
Published: February 2009

Abstractmagnified image1,8‐Diazabicyclo[5.4.0]undec‐7‐ene (DBU) efficiently catalyzes three‐component one‐pot condensations of aldehyde, malononitrile, and thiophenol to produce highly functionalized pyridines in excellent yield in aqueous ethanol. J. Heterocyclic Chem.,46, 69 (2009).
Surface‐enhanced Raman spectroscopy on novel black silicon‐based nanostructured surfaces
Authors: Talian Ivan , Mogensen Klaus Bo , Oriňák Andrej , Kaniansky Dušan , Hübner Jörg 
Published: February 2009

AbstractTwo different black silicon nanostructured surfaces modified with thin gold layers were tested for analytical signal enhancement with Surface‐Enhanced Raman Spectroscopy (SERS). The relationship between the thicknesses of the gold layers and the analytical signal enhancement was studied. Also, effects of Ti and Ti/Pt adhesion layers underneath the gold layers on the analytical signal enhancement were tested. An enhancement factor of 7.6 × 107 with the excitation laser 785 nm was achieved for the tested analyte, Rhodamine 6G, and non‐resonance SER spectra were recorded in a 5 s acquisition mode. Such an enhancement enables to achieve a detection limit down to 2.4 pg of Rhodamine 6G on a black silicon‐based nanosurface coated with a 400‐nm‐thin layer of gold. Copyright © 2009 John Wiley & Sons, Ltd.
Introducing the coaxial method of catheter port implantation for hepatic arterial infusion chemotherapy
Authors: Watanabe Masashi , Yamazaki Kunihiro , Yajima Satoshi , Tsuchiya Masaru , Ito Masaaki , Nanami Tatsuki , Oshima Yoko , Kaneko Hironori , Shimokawa Kontoku 
Published: February 2009

AbstractBackgroundHepatic arterial infusion chemotherapy (HAIC) is an effective method of treating patients with liver metastasis. However, in patients who have tortuous hepatic arteries, the procedure is extremely difficult with currently available methods. We have hence devised a method that is applicable in technically difficult circumstances called the coaxial method of cannulation.Methods and ResultsWhen compared to the conventional method of cannulation for HAIC, the coaxial method does not involve catheter exchange. This process is often associated with the flimsy micro‐guide wire dislodging out of the target artery, particularly if the patient has a torturous or stenosed artery. In the coaxial method, both the anti‐coagulated indwelling and coaxial catheters are placed in the artery together, with the coaxial catheter inside the indwelling catheter. The proximal ends of the catheter unit are attached to a connecting pipe, which subsequently connects to the implantable port. Our results show no differences in the cumulative patency rates of the hepatic artery between coaxial and conventional methods of HAIC.ConclusionIt is important to continually devise new methods to make HAIC technically less demanding. The coaxial method is free from catheter exchange, and therefore allows easier cannulation of difficult arteries. J. Surg. Oncol. 2009;99:382–385. © 2009 Wiley‐Liss, Inc.
Prognostic value of the ratio of metastatic lymph nodes in gastric cancer: An analysis based on a Chinese population
Authors: Wang Xi , Wan Fei , Pan Jun , Yu Guan‐Zhen , Chen Ying , Wang Jie‐Jun 
Published: February 2009

AbstractBackground and ObjectivesTo determine the prognostic value of the ratio of metastatic lymph nodes (RML) for gastric cancer and compare it to the prognostic value of the number‐based pN classification.MethodsThe survival of 513 patients who underwent curative resection between 2000 and 2005 was retrieved. The prognostic value of two factors for nodal status: RML classification (RML0, 0%; RML1, ≤30%; RML2, ≤50%; RML3, >50%) and pN classification (6th TNM system), was analyzed.ResultsBoth RML and pN classifications were independent prognostic factors when considered separately in multivariate analysis (P‐values < 0.05). Moreover, the proportion of explained variation (PEV) analysis showed that each classification had more prognostic value than other prognostic factors in two models respectively (P‐values < 0.05). The D‐measure for prognostic separation was 1.563 versus 1.383 for RML versus pN. Bootstrap results for the difference of D‐measures did not show a significant difference between RML and pN in terms of prognostic power (95% CI, −0.102 to 0.175).ConclusionsRML is an independent prognostic factor for gastric cancer. However, no significant evidence is found to support the hypothesis that RML classification carries more prognostic value than pN classification. J. Surg. Oncol. 2009;99:329–334. © 2009 Wiley‐Liss, Inc.
Time course of repeated intratympanic gentamicin for ménière's disease
Authors: Nguyen Kimanh D. , Minor Lloyd B. , Della Santina Charles C. , Carey John P. 
Published: February 2009

AbstractObjectives/Hypothesis:With low‐dose and titration protocols, subsequent intratympanic (IT) gentamicin injections are frequently necessary for vertigo control in Ménière's disease. To date, studies have not provided detailed descriptions of the time course of recurrent vertigo and repeated injections. Our objective is to provide such a description with a Kaplan‐Meier survival analysis, which may enable accurate predictions of the probability of recurrent vertigo after a given time or number of injections.Study Design:Injections of IT gentamicin were administered for unilateral definite Ménière's disease. One injection (or rarely more) in a 6‐week period constituted a “round.” Repeat rounds were given when needed for control of recurrent vertigo.Methods:We used a Kaplan‐Meier method to quantify percentages of patients with control of vertigo over an 8‐year period. A separate curve was created for each number of rounds, and failure for each was defined as the need for an additional round.Results:Of 78 patients, 75 (96%) achieved sufficient vertigo control to avoid ablative surgery, and 42 (54%) required only one round. Thirty‐six (46%) required multiple rounds. The probability of needing another round increased with each subsequent one, through four rounds. The median times to the next round after one, two, or three rounds were 148, 118, and 124 days, respectively.Conclusions:More than half of patients need only one round of IT gentamicin injections. With each additional round through the fourth one, the probability of additional rounds increases. Nevertheless, the majority (96%) of patients do not need ablative surgery after IT gentamicin. Laryngoscope, 2009
Characteristics of participants in a free oral, head and neck cancer screening program
Authors: Gourin Christine G. , Kaboli Kavon C. , Blume Erin J. , Nance Melonie A. , Koch Wayne M. 
Published: February 2009

AbstractObjective:Early detection of head and neck cancer is associated with improved survival. It is unclear if screening programs successfully target high‐risk populations. We sought to determine the characteristics of participants presenting for a free oral, head and neck cancer screening.Materials and Methods:Prospective analysis of 89 participants in a one‐day, free oral, head, and neck cancer screening.Results:The majority of participants were female (57%) and not tobacco users (71%) with a mean age of 56 years (range, 23–83). Symptoms associated with head and neck cancer were reported by 59 participants (66%), but only 31 (35%) were aware of an association between symptoms and head and neck cancer. There was no correlation between symptom prevalence and exam findings (r = 0.1161). Ten participants (11%) had findings concerning for neoplasia and were referred for immediate consultation. Demographically, 64 (72%) of participants had attended college and 51 (57%) earned an annual income greater then $30,000. The majority of participants (85%) believed that screening increased their awareness and knowledge of oral and head and neck cancer.Conclusions:Free oral, head and neck cancer screenings increase awareness of oral and head and neck cancer and identify a subset of individuals requiring further evaluation. However, participants do not share characteristics of the population at greatest risk for the development of head and neck cancer based on risk factors and socioeconomic status. These findings suggest that early detection efforts need to be designed to target high‐risk populations. Laryngoscope, 2009
Anti‐intercellular adhesion molecule‐1 antibody's effect on noise damage
Authors: Seidman Michael D. , Tang Wenxue , Shirwany Najeeb , Bai Uma , Rubin Cory J. , Henig Joseph P. , Quirk Wayne S. 
Published: February 2009

AbstractObjectives/Hypothesis:The purpose of this study was to investigate possible preventive effects of anti‐intercellular adhesion molecule‐1 antibody (anti‐ICAM‐1 Ab) on noise‐induced cochlear damage as assessed by changes in auditory thresholds and cochlear blood flow.Study Design:A controlled animal study. Pretreated rats with anti‐ICAM‐1 Ab or saline control, followed with exposure to 72 continuous hours of broad band noise (107 dB SPL), and 24 hours after noise exposure treated again with anti‐ICAM‐1 Ab or saline.Methods:Eighteen healthy male Fischer rats (200–250 g) were used. Sixteen were randomly selected to study noise‐induced temporary threshold shifts. The remaining two rats were used to study cochlear blood flow (CBF), using laser Doppler flowmetry and blood pressure measurements.Results:Rats treated with anti‐ICAM‐1 Ab (1.875 mg/kg, intravenously) showed attenuated temporary threshold shifts (TTS) compared to controls. Both groups showed a partial threshold recovery 72 hours following noise exposure, normal for this noise exposure paradigm. Comparisons of baseline and post‐treatment measurements of CBF and mean arterial blood pressure revealed no significant changes. Anti‐ICAM‐1 Ab animals displayed significantly lower mean auditory threshold shifts at all five test frequencies (P < .05) when compared to control.Conclusions:Blocking the cascade of reactive oxygen species (ROS) generation by using anti‐ICAM‐Ab protects against noise‐induced hearing loss. Laryngoscope, 2009
Cytotoxicity and antiangiogenesis by fibroblast growth factor 2–targeted Ad‐TK cancer gene therapy
Authors: Saito Koichiro , Khan Khurram , Sosnowski Barbara , Li Daqing , O'Malley Bert W. 
Published: February 2009

AbstractObjectives:Human head and neck squamous cell carcinoma (HNSCC) in addition to lung, skin, ovarian, and other cancers overexpress fibroblast growth factor (FGF) receptors on both individual tumor cells and endothelial cells within the tumor microenvironment. The purpose of this study was to investigate whether FGF2‐targeted gene therapy could redirect adenoviral vectors encoding the herpes simplex virus thymidine kinase gene (Ad‐TK) to FGF receptors on tumor and endothelial cells with the intent of improving both the efficiency of transgene expression and the antitumor response.Study Design and Methods:An Ad‐TK vector consisting of a conjugate of FGF2 linked to a Fab′ fragment against the adenoviral knob region was directly delivered to human HNSCC xenograft tumors in nude mice, which were subsequently dosed with ganciclovir. Tumor specimens were assessed for herpes simplex virus thymidine kinase (HSV‐tk) transgene mRNA expression, FGF1/2 receptor expression, terminal deoxynucleotidyl transferase biotin–deoxy uridine triphosphate nick end labeling assay for apoptosis, CD31 immunohistochemistry to estimate tumor microvessel density, and tumor volume change.Results:FGF2‐retargeted Ad‐TK gene therapy demonstrated significant increases in both HSV‐tk mRNA expression and cellular apoptosis levels, and a significant decrease in tumor volume size compared with all other groups. Furthermore, microvessel density was significantly lower in the FGF2‐retargeted Ad‐TK group, indicating a strong antiangiogenesis effect.Conclusions:These data suggest that FGF2‐retargeted Ad‐TK produces a combination of expected direct antitumor cytotoxicity and a newly reported antiangiogenesis effect that could prove promising as a novel therapeutic approach in the treatment of FGF receptor–expressing cancers. Laryngoscope, 2009
Contributions on the dynamic simulation of the virtual model of the human knee joint
Authors: Tarnita D. , Tarnita D.N. , Bizdoaca N. , Popa D. 
Published: February 2009

AbstractIn this paper, we are presenting the results of the research based on dynamic simulation of human knee virtual model. Starting from the parts realized with computer tomography help, there were realized virtual models for the femur, tibia, meniscus and ligaments that form the complex human knee joint, and their discretisation in finites elements.There were raised tension and deformation diagrams for the meniscus subjected to different stresses. There are presented comparative diagrams for tensions, deformations and deforming energy for the normal meniscus, and, respectively, for the totally cut meniscus, with a third of the volume, or two thirds of the volume.There were raised diagrams of the cinematic parameters (positions, speeds, accelerations) of the femur – lateral meniscus couple. Virtual models of the bony structures were subjected to different cinematic and dynamic simulations, separately, or in whole the human knee joint. Maps of tension were presented for the whole joint and for its components, to different movement moments.
Characterization of the mechanical properties of ultra‐fine grained NiTiCr‐wires
Authors: Frotscher M. , Burow J. , Schön P. , Neuking K. , Böckmann R. , Eggeler G. 
Published: February 2009

AbstractNiTiCr is used in medicine for retriever devices, dental‐ and guide wires [1–3]. Very little has been published in literature about this ternary NiTi‐alloy. In the present work, the mechanical properties of NiTiCr shape memory alloy (SMA) wires (0.25 wt.% Cr) in the as‐received condition and after a number of different heat treatments were studied. The surface quality of the wires was examined, because it is known that the surface condition has an influence on fatigue life. Mechanical uniaxial loading‐unloading tensile and cyclic tests were performed. Bending‐rotation fatigue (BRF) tests at higher rpm‐levels were conducted in air and in oil. This is important with regard to possible applications, where NiTiCr might be used as a structural component.
Fatigue and endurance of coronary stents
Authors: Weiß S. , Szymczak H. , Meißner A. 
Published: February 2009

AbstractCoronary stents have to sustain up to 700 million cycles induced by the cyclic diameter change of coronary arteries. Therefore fatigue tests are required to allow an accreditation or commercial utilization. In the present study coronary stents were investigated after cyclic fatigue in a stent tester. Several stents of equal design and equal test adjustments but with different cyclic expansion due to their position in the stent tester were compared. Microstructure characterization by means of scanning electron microscopy as well as single grain orientation determination shows the differences in microstructure and microtexture after different magnitudes of cyclic expansion. The present study will give a more comprehensive understanding of the influence of the test conditions on the structure property relationship under monotonic and cyclic load as a basis for ongoing development in stent optimization.
Comparison of the resorbable magnesium . alloys LAE442 und MgCa0.8 concerning their mechanical properties, their progress of degradation and the bone‐implant‐contact after 12 months implantation duration in a rabbit model
Authors: Thomann M. , Krause Ch. , Bormann D. , von der Höh N. , Windhagen H. , Meyer‐Lindenberg A. 
Published: February 2009

AbstractExtruded implants (2.5 mm x 25 mm) of the resorbable magnesium alloys MgCa0.8 and LAE442 were implanted into the marrow cavity of both tibiae of 10 New Zealand White rabbits. The animals were in a good general condition over the whole experimental period and showed no signs of lameness. Radiographic examinations could not reveal any generation of gas. The endosteal based bone adhesion to the implant surface was evaluated by μ‐computed tomography of the right tibia. 53 % of the evaluated slices of the alloy LAE442 showed an adherence of trabecular bone. MgCa0.8 showed trabeculae (38 %), bone clasps (13 %) and ‐rings (9 %) that covered the whole implant surface. Beside the weight and volume loss, the cross sectional area of the implants were measured to investigate the progress of degradation. Implants of the MgCa0.8 group showed an average loss of more than half of the original implant area (2.18 mm2 ± 1.03). In contrast LAE442 implants degraded very regularly (4.7 mm2 ± 0.07). Weight and volume measurements revealed a volume loss of 64.13 % ± 15.92 in the MgCa0.8 group and a lesser volume loss of 45.63 % ± 0.89 in the LAE442. The mechanical properties were tested by a three point bending test. It showed a decrease of the maximal force of 71.2 % ± 2.88 for LAE442 implants and of 85.6 % for MgCa0.8 implants, each compared to the initial condition.
Problems with the distribution of your health and medical information
Authors: Arnott Smith Catherine , Patrick Tim , Rhyner Paula , Swain Deborah , Davolio Leonard , Morris Ted 
Published: February 2009

AbstractSocial computing in the domain of health care is a vital, growing activity on the web. Patients, family, and healthcare professionals seek answers and share information. Knowledge management issues about accessing data and cultivating users have not been resolved. This panel has experiences to share based on research into the problems and issues that can separate each of us from personal medical and health records. Sometimes academic research in information science is separated by policies and practices from impacting the design of medical/healthcare world's information applications. Reliability and quality in health information and knowledge depend on bridging this gap.Panelists and attendees will discuss four aspects of the gap between research and practice. Panelists want to show how their IS research may help improve your access to records. During audience interaction, everyone will be asked to concentrate on the perspective of the PATIENT by asking these questions:

How do I know where my medical information comes from and goes in a system?
If I am just the patient, can I find the information I need?
As part of a large group of patients (or infected population), how can my data be shared for the public good?
What are the challenges and opportunities of using existing health information for the public good?
Format: Presentations (10 min. each) with Discussion (during and after panel presentations).