bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initiation of breastfeeding within 120 minutes after birth is associated with breastfeeding at four months among Japanese women: A self-administered questionnaire survey
Authors: Nakao Yuko , Moji Kazuhiko , Honda Sumihisa , Oishi Kazuyo 
Published: February 2008

Abstract

Background
The proportion of mothers in Japan who breastfeed exclusively has been low since the 1970s. The purpose of this study was to examine the association between the time of first breastfeed after birth and the proportion of mothers fully breastfeeding up to four months postpartum.

Methods
A survey was conducted using a self-administered questionnaire. The participants were 318 mothers who participated in a physical examination of their four month old infants in Nagasaki City, Japan in 2003.

Results
The time of first breastfeeding up to 120 minutes was significantly associated with the proportion of mothers fully breastfeeding during their stay in the clinic/hospital (p = 0.006), at one month (p = 0.004) and at four months after birth (p = 0.003). There was no significant difference in the proportion of full breastfeeding in mothers who first breastfed between the period of less 30 minutes after birth and that of between 31 and 120 minutes after birth. Logistic regression analysis indicated that the proportion of mothers who continued full breastfeeding at four months was significantly higher in those who breastfed their baby within 120 minutes compared with more than 120 minutes (OR 2.5, p = 0.01), but was not significantly different in those who breastfed within 30 minutes compared with more than 30 minutes (OR 1.8, p = 0.06). Early breastfeeding was affected by caesarean section, premature delivery and severe bleeding during delivery.

Conclusion
Commencement of early breastfeeding was associated with the proportion of mothers who fully breastfed their infants up to four months. Early breastfeeding, especially within two hours, is recommended for child and maternal health.
Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo
Authors: Wolman Marc A , Sittaramane Vinoth K , Essner Jeffrey J , Yost H Joseph , Chandrasekhar Anand , Halloran Mary C 
Published: February 2008

Abstract
Background
How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood. We have taken advantage of the unique features of the zebrafish embryo to visualize dynamic growth cone behaviors and analyze guidance mechanisms of axons emerging from a central brain nucleus in vivo.

Results
We investigated axons of the nucleus of the medial longitudinal fascicle (nucMLF), which are the first axons to extend in the zebrafish midbrain. Using in vivo time-lapse imaging, we show that both positive axon-axon interactions and guidance by surrounding tissue control initial nucMLF axon guidance. We further show that two guidance molecules, transient axonal glycoprotein-1 (TAG-1) and laminin-α1, are essential for the initial directional extension of nucMLF axons and their subsequent convergence into a tight fascicle. Fixed tissue analysis shows that TAG-1 knockdown causes errors in nucMLF axon pathfinding similar to those seen in a laminin-α1 mutant. However, in vivo time-lapse imaging reveals that while some defects in dynamic growth cone behavior are similar, there are also defects unique to the loss of each gene. Loss of either TAG-1 or laminin-α1 causes nucMLF axons to extend into surrounding tissue in incorrect directions and reduces axonal growth rate, resulting in stunted nucMLF axons that fail to extend beyond the hindbrain. However, defects in axon-axon interactions were found only after TAG-1 knockdown, while defects in initial nucMLF axon polarity and excessive branching of nucMLF axons occurred only in laminin-α1 mutants.

Conclusion
These results demonstrate how two guidance cues, TAG-1 and laminin-α1, influence the behavior of growth cones during axon pathfinding in vivo. Our data suggest that TAG-1 functions to allow growth cones to sense environmental cues and mediates positive axon-axon interactions. Laminin-α1 does not regulate axon-axon interactions, but does influence neuronal polarity and directional guidance.
Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedside
Authors: Devlin John W , Marquis Francois , Riker Richard R , Robbins Tracey , Garpestad Erik , Fong Jeffrey J , Didomenico Dorothy , Skrobik Yoanna 
Published: February 2008

Abstract
Background
While nurses play a key role in identifying delirium, several authors have noted variability in their ability to recognize delirium. We sought to measure the impact of a simple educational intervention on the ability of intensive care unit (ICU) nurses to clinically identify delirium and to use a standardized delirium scale correctly.

Methods
Fifty ICU nurses from two different hospitals (university medical and community teaching) evaluated an ICU patient for pain, level of sedation and presence of delirium before and after an educational intervention. The same patient was concomitantly, but independently, evaluated by a validated judge (ρ = 0.98) who acted as the reference standard in all cases. The education consisted of two script concordance case scenarios, a slide presentation regarding scale-based delirium assessment, and two further cases.

Results
Nurses' clinical recognition of delirium was poor in the before-education period as only 24% of nurses reported the presence or absence of delirium and only 16% were correct compared with the judge. After education, the number of nurses able to evaluate delirium using any scale (12% vs 82%, P < 0.0005) and use it correctly (8% vs 62%, P < 0.0005) increased significantly. While judge-nurse agreement (Spearman ρ) for the presence of delirium was relatively high for both the before-education period (r = 0.74, P = 0.262) and after-education period (r = 0.71, P < 0.0005), the low number of nurses evaluating delirium before education lead to statistical significance only after education. Education did not alter nurses' self-reported evaluation of delirium (before 76% vs after 100%, P = 0.125).

Conclusion
A simple composite educational intervention incorporating script concordance theory improves the capacity for ICU nurses to screen for delirium nearly as well as experts. Self-reporting by nurses of completion of delirium screening may not constitute an adequate quality assurance process.
Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia
Authors: Müller Stig , How Ole-Jakob , Hermansen Stig Eggen , Stenberg Thor Allan , Sager Georg , Myrmel Truls 
Published: February 2008

Abstract
Introduction
Arginine vasopressin (AVP) is increasingly used to restore mean arterial pressure (MAP) in low-pressure shock states unresponsive to conventional inotropes. This is potentially deleterious since AVP is also known to reduce cardiac output by increasing vascular resistance. The effects of AVP on blood flow to vital organs and cardiac performance in a circulation altered by cardiac ischemia are still not sufficiently clarified. We hypothesised that restoring MAP by low dose, therapeutic level AVP would reduce vital organ blood flow in a setting of experimental acute left ventricular dysfunction.

Methods
Cardiac output (CO) and arterial blood flow to the brain, heart, kidney and liver were measured in nine pigs using transit-time flow probes. Left ventricular pressure-volume catheter and central arterial and venous catheters were used for haemodynamic recordings and blood sampling. Transient left ventricular ischemia was induced by intermittent left coronary occlusions resulting in a 17% reduction in cardiac output and a drop in MAP from 87 ± 3 to 67 ± 4 mmHg (p < 0.001). A low-dose therapeutic level of AVP (0.005 U/kg/min) was used to restore MAP to pre-ischemic values (93 ± 4 mmHg).

Results
AVP further impaired systemic perfusion (CO and brain, heart and kidney blood flow reduced by 29, 18, 23 and 34%, respectively) due to a 2.0-, 2.2-, 1.9- and 2.1-fold increase in systemic, brain, heart and kidney specific vascular resistances. The hypoperfusion induced by AVP was associated with an increased systemic oxygen extraction. Oxygen saturation in blood drawn from the great cardiac vein fell from 29 ± 1 to 21 ± 3% (p = 0.01). Finally, these effects were reversed 40 min after AVP was withdrawn.

Conclusion
Low dose AVP induced a pronounced reduction in vital organ blood flow in pigs after transient cardiac ischemia. This indicates a potentially deleterious effect of AVP in patients with heart failure or cardiogenic shock due to impaired coronary perfusion.
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia
Authors: Chang Li Wei , Payton Jacqueline E , Yuan Wenlin , Ley Timothy J , Nagarajan Rakesh , Stormo Gary D 
Published: February 2008

Abstract
Background
Acute myeloid leukemia (AML) comprises a group of diseases characterized by the abnormal development of malignant myeloid cells. Recent studies have demonstrated an important role for aberrant transcriptional regulation in AML pathophysiology. Although several transcription factors (TFs) involved in myeloid development and leukemia have been studied extensively and independently, how these TFs coordinate with others and how their dysregulation perturbs the genetic circuitry underlying myeloid differentiation is not yet known. We propose an integrated approach for mammalian genetic network construction by combining the analysis of gene expression profiling data and the identification of TF binding sites.

Results
We utilized our approach to construct the genetic circuitries operating in normal myeloid differentiation versus acute promyelocytic leukemia (APL), a subtype of AML. In the normal and disease networks, we found that multiple transcriptional regulatory cascades converge on the TFs Rora and Rxra, respectively. Furthermore, the TFs dysregulated in APL participate in a common regulatory pathway and may perturb the normal network through Fos. Finally, a model of APL pathogenesis is proposed in which the chimeric TF PML-RARα activates the dysregulation in APL through six mediator TFs.

Conclusion
This report demonstrates the utility of our approach to construct mammalian genetic networks, and to obtain new insights regarding regulatory circuitries operating in complex diseases in humans.
Litigation as Ethnography in Sixteenth-Century Peru: Polo de Ondegardo and the Mitimaes
Authors: Mumford Jeremy Ravi 
Published: February 2008

Abstract
Scholars of colonialism have drawn attention to the link between litigation and ethnography. In nineteenth- and early twentieth-century Asia and Africa, European colonizers frequently tried to adjudicate local disputes according to conquered people’s own laws, which they therefore investigated and codified (creating much invented tradition in the process). This paper explores that link in sixteenth-century Spanish Peru, where, to a remarkable extent, recently conquered Andean people took their disputes to colonial courts. Spanish judges were supposed to decide intra-Andean disputes according to existing laws and customs but seldom actually tried to find out what those customs were. However, in cases where colonial elites were already interested in understanding specific indigenous institutions, litigation between rival Andean groups provided the context in which Spanish officials explored those institutions most profoundly.
As a case study, this paper examines the Spanish official Polo de Ondegardo and the Andean social category of mitmaqkuna or mitimaes, which were settlement enclaves created by the pre-Hispanic Inca state. Mitima networks undermined colonial policies of spatial clarity and social control but were legitimized by the prestige that the Incas’ memory carried in Andean society. They also appeared to be a basis for community prosperity in the bleak Andean highlands, a subject in which the Spanish conquerors, who depended on tribute from Andean communities, had a material stake. Through a series of lawsuits between indigenous parties, Spanish jurists—especially Ondegardo—developed explanations for this apparently alien social institution and integrated it into the colonial state.
Indigenous or Criollo: The Myth of White Argentina in Tucumán’s Calchaquí Valley
Authors: Chamosa Oscar 
Published: February 2008

Abstract
In contrast to its South American neighbors, Argentina holds a reputation as a “white” country, a presumption reflected in the discourse of national elites, scholars, and tour guides alike. This article explores the idea that this purported whiteness was the product of an ideological process that denied the existence of Argentines of non-European background. The case in point is the Calchaquí valley in the northwestern part of the country. The population of this valley was considered indigenous during the colonial period, but in the mid-twentieth century folklorists who surveyed the valley defined the population as criollo, that is, non-indigenous. The article demonstrates that, even though a certain creolization process did take place among the Calchaquí people during the nineteenth century, labeling them as criollos was a discursive operation manipulated by academic and local economic elites who had vested interests in defining the rural population of the northwest in general as non-indigenous.
Vitamin D Deficiency and Primary Hyperparathyroidism
Authors: Silverberg Shonni J 
Published: February 2008

Abstract
Temporally associated with the improvement in vitamin D nutrition in many Western countries in the mid-20th century, there was a change in many characteristics of primary hyperparathyroidism. Osteitis fibrosa cystica became a rare manifestation of what is now frequently an asymptomatic disease. At the same time, in patients with the disease, levels of PTH and parathyroid adenoma weights have fallen dramatically. In view of these observations and others, an association between vitamin D deficiency and severity of primary hyperparathyroidism has been proposed. Data support an association on two distinct levels. First, regardless of the clinical severity of primary hyperparathyroidism, the disease seems to be more severe in those with concomitant vitamin D deficiency. Second, vitamin D deficiency and insufficiency seem to be more prevalent in patients with primary hyperparathyroidism than in geographically matched populations. The association between vitamin D deficiency and primary hyperparathyroidism has clear implications. Co-existing vitamin D deficiency may cause the serum calcium level to fall into the normal range, which can lead to diagnostic uncertainty. With regard to management, preliminary data on vitamin D repletion in patients with mild primary hyperparathyroidism suggest that, in some cases, correction of vitamin D deficiency may be accomplished without worsening the underlying hypercalcemia. Vitamin D–deficient patients undergoing parathyroidectomy are also at increased risk of postoperative hypocalcemia and “hungry bone syndrome,” which underscores the importance of preoperative assessment of vitamin D status in all patients with primary hyperparathyroidism.
Vitamin D Endocrine Physiology
Authors: Heaney Robert P 
Published: February 2008

Abstract
Quantitative aspects of vitamin D3 endocrine physiology are briefly reviewed, together with the supporting evidence. Net calcium absorption of at least 200 mg/d is required to offset typical obligatory losses and thereby to protect the skeleton. The ability of the body to regulate intestinal calcium absorption is optimal at serum 25-hydroxyvitamin D3 concentrations &gt;80 nM. Vitamin D3 inputs from all sources required to sustain such a level amount to 3600–4200 IU/d. Daily oral intakes as high as 10,000 IU are safe.
Epidemiological Evidence for Vitamin D and Colorectal Cancer
Authors: Giovannucci Edward 
Published: February 2008

Abstract
Since Garland and Garland formulated the hypothesis that vitamin D may protect against colorectal cancer in 1980, various epidemiological approaches have been undertaken to evaluate this hypothesis. These approaches include studies based on regional solar UVB radiation, plasma- or serum-based studies, dietary studies, and those examining multiple factors that influence vitamin D status. Studies over the past several decades have tended to support that higher levels of vitamin D may decrease risk of colorectal cancer. An important implication is that current recommended dietary intakes such as 200–400 IU/d may be too low to exert appreciable benefits. To substantially reduce risk, higher levels of vitamin D associated with sunshine exposure or considerably higher intakes may be required. Recent studies also suggest a potential benefit of vitamin D on other digestive system cancers. One study suggested that a better vitamin D status at the time of diagnosis and treatment, as indicated by season of diagnosis, may improve survival from colorectal cancer. Darker-skinned individuals who tend to make less vitamin D may be at particularly high risk for digestive system cancer. The strong biological evidence for a protective role of vitamin D supports the epidemiological data. More study is needed to determine the optimal levels and intakes of this vitamin to optimally reduce colorectal cancer risk.
Vitamin D Insufficiency/Deficiency in Gastrointestinal Disorders
Authors: Bikle Daniel D 
Published: February 2008

Abstract
Vitamin D and calcium are critical for skeletal health. Their absorption from the intestine is negatively impacted by a number of gastrointestinal diseases and surgical procedures, leading to osteoporosis and/or osteomalacia. Diseases of the liver can impact the metabolism of vitamin D to its circulating form, 25(OH)D, as well as the production of carrier proteins, albumin and vitamin D–binding protein, that may alter the delivery of 25(OH)D and its active metabolite 1,25(OH)2D to target tissues, including the skeleton, again leading to bone disease. The clinician evaluating a patient with apparent osteoporosis and vitamin D deficiency/ insufficiency needs to consider a gastrointestinal etiology. Similarly, the clinician evaluating a patient with a gastrointestinal disorder needs to evaluate that patient for vitamin D deficiency and bone disease. Treatment involves adequate vitamin D and calcium supplementation to achieve normal serum 25(OH)D, PTH, and serum and urine calcium levels.
Vitamin D Receptor Agonists in the Treatment of Autoimmune Diseases: Selective Targeting of Myeloid but Not Plasmacytoid Dendritic Cells
Authors: Penna Giuseppe , Amuchastegui Susana , Laverny Gilles , Adorini Luciano 
Published: February 2008

Abstract
Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types. More recently, it has become clear that VDR agonists possess immunoregulatory properties and, in particular, pronounced protolerogenic activities. These agents have been shown to be effective in several models of autoimmune diseases and are the most used topical agents in the treatment of psoriasis, a Th1 and Th17 cell-mediated autoimmune disease of the skin, indicating their potential applicability in the treatment of a variety of autoimmune diseases. VDR agonists can act directly on T cells, but dendritic cells (DCs) seem to be their primary targets. A potentially very important activity of VDR agonists is their capacity to induce in vitro and in vivo tolerogenic DCs able to enhance CD4+CD25+ suppressor T cells that, in turn, inhibit effector T-cell responses. Novel data now show that VDR agonists selectively modulate tolerogenic properties in blood myeloid but not plasmacytoid DCs, shedding new light on the multifaceted immunoregulatory properties of these agents.
Vitamin D Economy in Blacks
Authors: Cosman Felicia , Nieves Jeri , Dempster David , Lindsay Robert 
Published: February 2008

Abstract
The fact that fracture risk is lower and BMD is higher in blacks compared with whites is surprising in light of what is known about vitamin D status in blacks. Mean 25(OH)D levels are lower in blacks than whites at all stages of life, and a greater proportion of blacks meet criteria for vitamin D deficiency. The racial difference in serum 25(OH)D level is primarily caused by increased pigmentation reducing vitamin D production in the skin. In response to lower 25(OH)D levels and lower average calcium intake, blacks have higher average PTH levels and a higher prevalence of secondary hyperparathyroidism (twice the prevalence compared with whites for both sexes). This is associated with higher average levels of 1,25(OH)2D and lower urinary calcium excretion but not higher biochemical indices of bone turnover. In fact, in general, biochemical indices of bone formation (particularly osteocalcin levels) are lower in blacks. Bone formation rates assessed histomorphometrically are also lower, although wall thickness is maintained. During a 24-h PTH infusion, increments in levels of three different bone resorption markers are significantly lower in blacks than in whites, providing direct confirmation of the thesis that the black skeleton is resistant to the bone-resorbing effects of PTH, whereas renal sensitivity to PTH is maintained or perhaps even enhanced. Vitamin D supplementation studies in black women have shown inconsistent benefits to BMD. Skeletal and renal adaptations to vitamin D deficiency in blacks might be so effective that vitamin D supplementation might not confer any further benefit to the black skeleton. Benefits of vitamin D supplements in blacks may still play a role, however, in the prevention of other chronic diseases.
Code switching and the globalisation of popular music: The case of North African rai and rap
Authors: Davies Eirlys E , Bentahila Abdelali 
Published: February 2008

Abstract
Present trends towards the globalisation and hybridisation of popular music genres are illustrated through an examination of two types of music currently popular in North Africa: rai, a genre originating in Algeria and now becoming better known in the West, and rap, a product of the West which has now been appropriated by Algerian and Moroccan performers. Parallels are drawn between the paths followed by these two genres. The study focuses on the use made of code switching between Arabic and French in both genres. Different patterns of switching are identified and their funtions explored. It is argued that in both genres switching may be used both as a localising device, through the use of a highly specific in-group variety, and as a device which opens up the lyrics to a wider range of audiences.
Unpacking “The Theta System”
Authors: Alsina Alex 
Published: February 2008

Abstract
When we consider a new theory and we wish to uncover its merits and shortcomings, it is necessary to take into account the data that support both the theory as a whole and each individual assumption that makes up the theory and to compare it with alternative theories and assumptions that have similar descriptive and explanatory goals. This is what I will do in the following pages with Reinhart's “The Theta System”.
Rules that govern the cooccurences of theta-clusters in the ‘Theta-System’
Authors: Marelj Marijana 
Published: February 2008

Abstract

0. Introduction

In order to be legible to the CS, thematic roles in the ‘Theta-System’ (Reinhart, this volume) are formally coded in terms of two binary features: +/−c (cause change) and +/−m (mental state).