bluuebunny/crossref_metadata_2025_split huggingface dataset:
Algorithm for Exhaustive and Nonredundant Organic Stereoisomer Generation.
Authors: Contreras M. L. , Alvarez J. , Guajardo D. , Rozas R. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
MIMUMBA Revisited: Torsion Angle Rules for Conformer Generation Derived from X‐Ray Structures.
Authors: Sadowski Jens , Bostroem Jonas 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemoinformatics‐Based Classification of Prohibited Substances Employed for Doping in Sport.
Authors: Cannon Edward O. , Bender Andreas , Palmer David S. , Mitchell John B. O. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
“Bayes Affinity Fingerprints” Improve Retrieval Rates in Virtual Screening and Define Orthogonal Bioactivity Space: When Are Multitarget Drugs a Feasible Concept?
Authors: Bender Andreas , Jenkins Jeremy L. , Glick Meir , Deng Zhan , Nettles James H. , Davies John W. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fuzzy Tricentric Pharmacophore Fingerprints. Part 1. Topological Fuzzy Pharmacophore Triplets and Adapted Molecular Similarity Scoring Schemes.
Authors: Bonachera Fanny , Parent Benjamin , Barbosa Frederique , Froloff Nicolas , Horvath Dragos 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Adaptive Configuring of Radial Basis Function Network by Hybrid Particle Swarm Algorithm for QSAR Studies of Organic Compounds.
Authors: Zhou Yan‐Ping , Jiang Jian‐Hui , Lin Wei‐Qi , Zou Hong‐Yan , Wu Hai‐Long , Shen Guo‐Li , Yu Ru‐Qin 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Novel Small Chemical Inhibitors for Lck SH Domain with in vitro T‐Cell Inhibitory Activity.
Authors: Park See‐Hyoung , Kang Mi‐Ae , Shim Hyeong‐Soo , Cho Hyeongjin , Won Jonghwa , Lee Keun‐Hyeung 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Computer‐Aided Rational Design of Catalytic Antibodies: The 1F7 Case.
Authors: Marti S. , Andres J. , Silla E. , Moliner V. , Tunon I. , Bertran J. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thin Films Prepared by Ion Layer Gas Reaction (ILGAR)
Authors: Bar M. , Muffler H.‐J. , Allsop N. , Fischer Ch.‐H. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
σ‐Chelation‐Directed C—H Functionalizations Using Pd(II) and Cu(II) Catalysts: Regioselectivity, Stereoselectivity and Catalytic Turnover
Authors: Yu Jin‐Quan , Giri Ramesh , Chen Xiao 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Applications of Chiral Ferrocene Ligands in Asymmetric Catalysis
Authors: Gomez Arrayas Ramon , Adrio Javier , Carretero Juan Carlos 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solid‐State Structure, Organization and Properties of Peptide‐Synthetic Hybrid Block Copolymers
Authors: Klok Harm‐Anton , Lecommandoux Sebastien 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Revising the Proton Affinity Scale of the Naturally Occurring α‐Amino Acids
Authors: Bleiholder Christian , Suhai Sandor , Paizs Bela 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyclodextrin‐Based Supramolecular Polymers
Authors: Harada Akira , Hashidzume Akihito , Takashima Yoshinori 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supramolecular Chemistry of Bile Acid Derivatives: Formation of Gels
Authors: Babu Ponnusamy , Sangeetha Neralagatta M. , Maitra Uday 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Homogeneous Cobalt‐Promoted Carbonylations and Related Reactions: The Last 15 Years
Authors: Cabrera Armando , Arias Jose Luis , Sharma Pankaj , Rosas Noe 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Role of the N—B Dative Bond in the Macrocyclization of Boron Compounds
Authors: Barba Victor , Santillan Rosa , Farfan Norberto 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lipase‐Catalyzed Deacylation by Alcoholysis — A Selective, Useful Transesterification Reaction
Authors: Santaniello Enzo , Casati Silvana , Ciuffreda Pierangela 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Low‐Dose Radiation Effects and Intracellular Signaling Pathways
Authors: Suzuki Keiji , Kodama Seiji , Watanabe Masami 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
DNA Logic Gates Based on Structural Polymorphism of Telomere DNA Molecules Responding to Chemical Input Signals
Authors: Miyoshi Daisuke , Inoue Mamiko , Sugimoto Naoki 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase
Authors: Prazeres Verónica F. V. , Sánchez‐Sixto Cristina , Castedo Luis , Lamb Heather , Hawkins Alastair R. , Riboldi‐Tunnicliffe Alan , Coggins John R. , Lapthorn Adrian J. , González‐Bello Concepción 
Published: January 2007

AbstractIsomeric nitrophenyl and heterocyclic analogues of the known inhibitor (1S,3R,4R)‐1,3,4‐trihydroxy‐5‐cyclohexene‐1‐carboxylic acid have been synthesized and tested as inhibitors of M. tuberculosis and S. coelicolor type II dehydroquinase, the third enzyme of the shikimic acid pathway. The target compounds were synthesized by a combination of Suzuki and Sonogashira cross‐coupling and copper(I)‐catalyzed 2,3‐dipolar cycloaddition reactions from a common vinyl triflate intermediate. These studies showed that a para‐nitrophenyl derivative is almost 20‐fold more potent as a competitive inhibitor against the S. coelicolor enzyme than that of M. tuberculosis. The opposite results were obtained with the meta isomer. Five of the bicyclic analogues reported herein proved to be potent competitive inhibitors of S. coelicolor dehydroquinase, with inhibition constants in the low nanomolar range (4–30 nM). These derivatives are also competitive inhibitors of the M. tuberculosis enzyme, but with lower affinities. The most potent inhibitor against the S. coelicolor enzyme, a 6‐benzothiophenyl derivative, has a Ki value of 4 nM—over 2000‐fold more potent than the best previously known inhibitor, (1R,4R,5R)‐1,5‐dihydroxy‐4‐(2‐nitrophenyl)cyclohex‐2‐en‐1‐carboxylic acid (8 μM), making it the most potent known inhibitor against any dehydroquinase. The binding modes of the analogues in the active site of the S. coelicolor enzyme (GOLD 3.0.1), suggest a key π‐stacking interaction between the aromatic rings and Tyr 28, a residue that has been identified as essential for enzyme activity.
A [meso‐Tetrakis(4‐sulfonatophenyl)porphyrinato]zinc(II) Complex As an Oral Therapeutic for the Treatment of Type 2 Diabetic KKAy Mice
Authors: Saha Tapan K. , Yoshikawa Yutaka , Sakurai Hiromu 
Published: January 2007

AbstractWe prepared and characterized [meso‐tetrakis(4‐sulfonatophenyl)porphyrinato]zinc(II) ([Zn(tpps)]), and investigated its in vitro insulin‐mimetic activity and in vivo hypoglycemic effect in type 2 diabetic KKAy mice. The results were compared with those of previously proposed insulin‐mimetic zinc(II) complexes and zinc sulfate (ZnSO4). The in vitro insulin‐mimetic activity of [Zn(tpps)] was considerably better than that of bis(allixinato)zinc(II) ([Zn(alx)2]), bis(maltolato)zinc(II) ([Zn(mal)2]), bis(2‐aminomethylpyridinato)zinc(II) ([Zn(2‐ampy)2]2+), and ZnSO4. In particular, the order of in vitro insulin‐mimetic activity of the complexes was determined to be: [Zn(tpps)]>[Zn(alx)2]>[Zn(mal)2]>[Zn(2‐ampy)]2+>ZnSO4. [Zn(tpps)] normalized the hyperglycemia of KKAy mice within 21 days when administered orally at doses of 10–20 mg (0.15–0.31 mmol) Zn per kg body mass for 28 days. In addition, metabolic syndromes such as insulin resistance, the degree of renal disturbance, and the degree of liver disturbance were significantly improved in [Zn(tpps)]‐treated KKAy mice relative to those administered with saline and ZnSO4. The improvement in diabetes was validated by the results of oral glucose‐tolerance tests and the decrease in the HbA1c level observed. In contrast, ZnSO4 and the ligand H2tpps did not lower the elevated blood glucose level under the same experimental conditions. Based on these observations, [Zn(tpps)] is proposed to be the first orally active zinc(II)–porphyrin complex for the efficacious treatment of not only type 2 diabetes but also metabolic syndromes in animals.
Developing a successful sector sustainability strategy: six lessons from the UK construction products industry
Authors: Holton Ian , Glass Jacqui , Price Andrew 
Published: January 2007

AbstractSector sustainability strategies can provide frameworks to help business sectors identify and manage economic, environmental and social risks in an integrated way, and unlock opportunities to improve competitiveness and enhance reputation. They can also help trade associations to become more effective champions for their members; however, little research has been undertaken on their development. Current best practice guidance simply provides frameworks for managing the strategy development process. To add to this guidance, the context, purpose, process and content of three strategies from the UK construction products industry have been investigated. Strategy context and content were found to be unique; it is therefore not considered feasible to develop a generic sector sustainability strategy. However, six lessons have been identified with respect to strategy purpose and process, which may improve the chances of success of a sector sustainability strategy. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
slowmo is required for Drosophila germline proliferation
Authors: Reeve Simon , Carhan Ahmet , Dee Chris T. , Moffat Kevin G. 
Published: January 2007

AbstractNull mutations in the Drosophila gene, slowmo (slmo), result in reduced mobility and lethality in first‐instar larvae. Slowmo encodes a mitochondrial protein of unknown function, as do the two other homologs found in Drosophila. Here, we have studied a hypomorphic P‐element allele of slmo demonstrating its effects on germline divisions in both testes and ovaries. Using in situ studies, enhancer‐trap activity, and promoter fusions, we have shown that slmo expression in testes is found in the somatic cyst cells (SCC). The hypomorphic allele for Slmo revealed apoptotic loss of germline cells in the larval germline, culminating in a complete absence of the germline in adult flies. In females, a similar degeneration of the germarium is observed, while reporter gene expression is found in both germline and somatic cells. Using a null mutation in female germline clones, we find slmo is dispensable from the germline cells. Our results suggest that Slowmo is not required in germline cells directly, but is required in SCCs responsible for maintaining germline survival in both sexes. genesis 45:66–75, 2007. © 2007 Wiley‐Liss, Inc.
GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen
Authors: Moriyama Akemi , Kii Isao , Sunabori Takehiko , Kurihara Suguru , Takayama Issei , Shimazaki Masashi , Tanabe Hideyuki , Oginuma Masayuki , Fukayama Masashi , Matsuzaki Yumi , Saga Yumiko , Kudo Akira 
Published: January 2007

AbstractIn the past decades, the function of the Wnt canonical pathway during embryogenesis has been intensively investigated; however, little survey of neonatal and adult tissues has been made, and the role of this pathway remains largely unknown. To investigate its role in mature tissues, we generated two new reporter transgenic mouse lines, ins‐TOPEGFP and ins‐TOPGAL, that drive EGFP and β‐galactosidase expression under TCF/β‐catenin, respectively. To obtain the accurate expression pattern, we flanked these transgenes with the HS4 insulator to reduce chromosomal positional effects. Analysis of embryos showed that the reporter genes were activated in regions where canonical Wnt activity has been implicated. Furthermore, their expression patterns were consistent in both lines, indicating the accuracy of the reporter signal. In the neonatal brain, the reporter signal was detected in the mesencephalon and hippocampus. In the adult mice, the reporter signal was found in the mature pericenteral hepatocytes in the normal liver. Furthermore, during inflammation the number of T cells expressing the reporter gene increased in the adult spleen. Thus, in this research, we identified two organs, i.e., the liver and spleen, as novel organs in which the Wnt canonical signal is in motion in the adult. These transgenic lines will provide us broader opportunities to investigate the function of the Wnt canonical pathway in vivo. genesis 45:90–100, 2007. © 2007 Wiley‐Liss, Inc.
Generation of a conditional disruption of the Tsc2 gene
Authors: Hernandez Omar , Way Sharon , McKenna James , Gambello Michael J. 
Published: January 2007

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 gene. Patients afflicted with TSC develop tumors in various organ systems, but cerebral pathology is particularly severe. Conventional gene disruption of the Tsc1 or Tsc2 gene in mice cause limited central nervous system pathology. Homozygous deletion of either gene causes midgestation lethality. To circumvent the homozygous lethality of the conventional Tsc2 knockout we have generated a conditional allele of the Tsc2 gene by homologous recombination in mouse ES cells. The homozygous Tsc2flox/flox mice are identical to wildtype in many organs typically affected by TSC, especially the brain. Using this Tsc2flox allele we have generated a null allele using Cre recombination. This allele will be useful in investigating TSC pathology with appropriate cell and organ specific Cre‐transgenic mice. genesis 45:101–106, 2007. © 2007 Wiley‐Liss, Inc.
Religious participation as a predictor of mental health status and treatment outcomes in older persons
Authors: Chen Hongtu , Cheal Karen , McDonel Herr Elizabeth C. , Zubritsky Cynthia , Levkoff Sue E. 
Published: January 2007

AbstractObjectivesThis study focuses on examining the relations of religious participation and affiliation to mental health status among older primary care patients, and to the use and clinical outcomes of mental health services.MethodsA sample of older adults participating in a clinical study (PRISM‐E) to treat their depression with or without co‐morbid anxiety (n = 1610) were queried about their religious affiliation and the frequency of their participation in religious activities. The diagnoses of depressive and anxiety disorders were made based on the MINI‐International Neuropsychiatric Interview. Severity of depressive disorders was assessed by emotional distress using the CES‐D.ResultsThose attending religious activities on a weekly, monthly, or occasional basis were significantly less likely to have suicidal ideation (p < 0.02) and emotional distress (p < 0.0001) than those who never participated or participated on a less frequent basis. Frequency of religious participation was not associated with mental health service utilization (p = 0.16), but it was predictive of a lower CES‐D score at the end of the study intervention (p < 0.001).ConclusionsReligious participation is positively associated with older adults' mental health status and treatment effects, but results regarding mental health service utilization were inconclusive. Copyright © 2007 John Wiley & Sons, Ltd.
Co‐occurrence of chronic physical pain and psychiatric morbidity in a community sample of older people
Authors: Blay Sergio Luís , Andreoli Sergio Baxter , Dewey Michael E. , Gastal Fábio Leite 
Published: January 2007

AbstractBackgroundKnowledge about co‐occurrence of the most frequent chronic pain symptoms with psychiatric morbidity in older people is very limited.ObjectiveTo study the association of psychiatric morbidity and painful physical conditions in people aged 60 years and over.MethodPopulation‐based random sample of 7,040 household residents, aged 60 years and over, in Brazil.ResultsThe overall prevalence of pain conditions is 76%. Age‐sex specific prevalence of chronic pain conditions such as back pain, joint, abdominal, chest, headaches, reported by respondents ranged from 11.6% up to 51.1%. In logistic regression models, chest pain, head pain, back pain, joint pain and abdominal pain emerged as predictors of psychiatric morbidity. The odds of psychiatric morbidity are also affected by income, ethnicity, origin (urban/rural), and marital status.ConclusionThe association of chronic painful conditions and psychiatric morbidity in late life is statistically strong in this surveyed population. Copyright © 2007 John Wiley & Sons, Ltd.
The Weigl Colour‐Form Sorting Test: a quick and easily administered bedside screen for dementia and executive dysfunction
Authors: Hobson Peter , Meara Jolyon , Taylor Caroline 
Published: January 2007

AbstractBackgroundScreening for cognitive impairment in hospital and the community requires a valid, reliable, concise, well tolerated, easily administered instrument. In this investigation, we have studied a non‐verbal cognitive screening instrument; Weigl's Colour‐Form Sorting Test (WCFT), to determine its utility as a brief cognitive screen in a community based sample of stroke survivors, Parkinson's disease (PD) patients and age/sex matched controls.MethodsA total of 236 subjects consented to participate in this investigation, consisting of 105 stroke survivors, 40 PD and 91 control subjects. The sensitivity and specificity of the WCFT to detect significant cognitive impairment was based upon psychiatric interview, cognitive assessment and application of DSMIV criteria.ResultsThe optimal cut‐point of the WCFT to detect cases of cognitive impairment was 2/4 in all of the groups in this investigation. The sensitivity and specificity of the WCFT at the cut point of 2 in the stroke survivors was 77.8% and 78.3, in the PD patients, it was 78.6% and 85.5% and, in the control group 83.3% and 94.1% respectively. The diagnostic accuracy of the WCFT as calculated by the area under the receiver operating curve was greater than 0.70 in all subject groups, which suggests that it has acceptable psychometric properties to discriminate between case and non‐cases of cognitive impairment.ConclusionThe WCFT was able to demonstrate good sensitivity and specificity, at detecting cognitive impairments in all of the subjects. This instrument will prove to be a useful adjunct to existing cognitive screens in clinical practice, due to its excellent psychometric properties, and lack of dependency on language skills. Copyright © 2007 John Wiley & Sons, Ltd.
Modification of chitin properties for enzymatic deacetylation
Authors: Beaney Paul D. , Gan Quan , Magee Thomas R. A. , Healy Michael , Lizardi‐Mendoza Jaime 
Published: January 2007

AbstractChitins produced via a conventional chemical route as well as from a new biological process were modified to increase the efficiency of enzymatic deacetylation reactions for the production of novel biological chitosan. These modified chitins were reacted for 24 h with extracellular fungal enzymes from Colletotrichum lindemuthianum. The chemical and physical properties of the various substrates were analysed and their properties related to the effectiveness in the deacetylation reaction. Modifications of the chitins affected the degree of deacetylation with varied effects. Without further modification to reduce crystallinity and to open up the solid substrate structure, the chitins were found to be poor substrates for the heterogeneous solid‐liquid enzymatic catalysis. It was found that the solvent and drying method used in modifying the chitins had significant impact on the final efficiency of the enzymatic deacetylation reaction. The most successful modifications through freeze drying of a colloidal chitin suspension increased the degree of enzymatic deacetylation by 20 fold. These processes reduce the crystallinity of the chitin making it easier for the enzymes to access their internal structure. X‐ray diffraction, scanning electron microscopy, thermogravimetric analysis, and BET isotherm analysis are employed to characterise the modified chitins to ascertain the degree of crystallinity, porous structure, surface area, and morphology. Copyright © 2007 Society of Chemical Industry