bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing language skills and student engagement: investigating the impact of Quizlet in teaching Chinese as a foreign language
Authors: Ma Xiaohan 
Published: February 2024

AbstractThis research explores the use of the Quizlet application in teaching Chinese as a foreign language, employing a mixed methods approach. The participants of this study were 60 international students who majored in Chinese at a university in China. The students were divided into two groups and received instruction through traditional teaching methods and Quizlet-based teaching activities, respectively. The pre-and post-performance tests were used to collect quantitative data on students’ Chinese listening, speaking, reading, and writing scores, while the open-ended questions were used to measure qualitative data on student engagement. The integration of Quizlet is found to enhance Chinese listening, speaking, and reading skills, promoting student engagement through behavioral, emotional, and cognitive dimensions. However, its influence on writing skills is less significant, warranting further investigation. The results of this study endorse Quizlet as a valuable tool for language instruction, highlighting its potential for facilitating Chinese language education and inspiring innovative teaching methods.
Exploring the therapeutic role of early heparin administration in ARDS management: a MIMIC-IV database analysis
Authors: Xiao Ling-Xi , Zhu De Liang , Chen Juan , Lv Jing , Liu Mei-Jun , Dai Xue , Wang Dao-Xin , Deng Wang 
Published: February 2024

Abstract
Background
Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by a high mortality rate, the management of which relies on supportive care and a profound understanding of its pathophysiology. Heparin, with its anticoagulant and potential anti-inflammatory properties, offers a new therapeutic opportunity for the treatment of ARDS.

Methods
In this retrospective cohort study, we examined the MIMIC-IV database for ARDS patients who received prophylactic heparin within the first 72 h of ICU admission. Employing propensity score matching and inverse probability weighting (IPW) analysis, we evaluated the impact of early heparin use on patient outcomes, focusing on mortality rates.

Results
Patients who received prophylactic heparin had a significantly lower in-hospital mortality rate compared to those who did not (13.55% vs 17.93%, HR = 0.71, 95% CI: 0.54–0.93, P = 0.012). This result remained significant after propensity score matching (12.75% vs 17.93%, HR = 0.65, 95% CI 0.47–0.90, P = 0.010). Analysis using five different statistical models indicated that early use of heparin significantly reduced the in-hospital mortality rate, with HR = 0.669 (95% CI 0.487–0.919, P = 0.013) in the doubly robust model without balanced covariates; HR = 0.705 (95% CI 0.515–0.965, P = 0.029) with all covariates considered; HR = 0.660 (95% CI 0.491–0.888, P = 0.006) in the propensity score (IPW) model; HR = 0.650 (95% CI 0.470–0.900, P = 0.010) in the propensity score matching model; and HR = 0.706 (95% CI 0.536–0.930, P = 0.013) in the multivariate Cox regression model. Secondary outcomes indicated that heparin use was also associated with reduced mortality rates at 60 days, and 90 days.

Conclusion
This research highlights that early prophylactic administration of heparin may substantially lower mortality in ARDS patients. These findings underscore the potential of heparin as a key component in the management of ARDS, offering a new perspective and novel strategies for clinical treatment.
Materials descriptors of machine learning to boost development of lithium-ion batteries
Authors: Wang Zehua , Wang Li , Zhang Hao , Xu Hong , He Xiangming 
Published: February 2024

AbstractTraditional methods for developing new materials are no longer sufficient to meet the needs of the human energy transition. Machine learning (ML) artificial intelligence (AI) and advancements have caused materials scientists to realize that using AI/ML to accelerate the development of new materials for batteries is a powerful potential tool. Although the use of certain fixed properties of materials as descriptors to act as a bridge between the two separate disciplines of AI and materials chemistry has been widely investigated, many of the descriptors lack universality and accuracy due to a lack of understanding of the mechanisms by which AI/ML operates. Therefore, understanding the underlying operational mechanisms and learning logic of AI/ML has become mandatory for materials scientists to develop more accurate descriptors. To address those challenges, this paper reviews previous work on AI, machine learning and materials descriptors and introduces the basic logic of AI and machine learning to help materials developers understand their operational mechanisms. Meanwhile, the paper also compares the accuracy of different descriptors and their advantages and disadvantages and highlights the great potential value of accurate descriptors in AI/machine learning applications for battery research, as well as the challenges of developing accurate material descriptors.
Graphical Abstract
Patterns of co-evolution: analyzing fashion brand and sewing contractor company dynamics
Authors: Kwon Ki Yong 
Published: February 2024

AbstractThe purpose of this study is to identify the entry conditions that could form a co-evolutionary relationship between a sewing contractor company and a fashion brand, and reveal the outcome of such a relationship. In the Republic of Korea, many fashion brands and sewing companies coexist, and the situation in the fashion industry changes with the rapid development of the country, so it is a suitable environment for investigating their co-evolution strategies. A qualitative research methodology was used to examine the co-evolution process of the fashion brand and the sewing industry. In addition, an objective evaluation was conducted by using interviews with sewing contractor companies and fashion brands that have business relationships with the sewing contractor companies. The results indicated that sewing contractor companies evolve into either mass production or small production systems. In the co-evolutionary process, relational resources and business-to-business transaction suitability are the main entry conditions for sewing contractor companies to coevolve with fashion brands. Knowledge exchange, experience optimization, off-season ordering, and investment in trading companies were observed among sewing contractor companies that formed a co-evolutionary relationship with their fashion brand partners. This study identified and conceptualized factors that played a major role in the process of co-evolution and proved suitable for each production system of sewing contractor companies.
A community-based intervention study involving family gardens with aromatic herbs on changes in dietary and urinary sodium
Authors: Baston M. , Hernández-F M. , Vázquez K. , Ruiz-Morales M. , Mehner-Karam P. , Sil-Acosta M. , Acevedo N. , Granich-Armenta A. , Holz K. , Cantoral A. 
Published: February 2024

Abstract
Objective
To measure dietary and urinary changes in sodium (Na) intake and excretion through the implementation of family gardens with aromatic herbs and workshops for cooking, using the herbs as a substitute for salt and seasoning powder.

Methods
Thirty-five participants from a neighborhood of Mexico City were included. A general questionnaire was administered to collect information on sociodemographic factors. At baseline and 3 months later, a dietary evaluation was conducted, and 24-hour urine samples were collected. Food items reported were classified according to the NOVA classification. Visits to participants´ houses were conducted to measure the amount of salt and seasoning powder added to food during the preparation of meals as well as a home food inventory. All participants were given a family garden with 6 aromatic herbs and a recipe book. The intervention included 7 cooking and 3 garden care workshops. Qualitative information on the experience was also collected. Linear regression models were run in order to estimate the contribution of each NOVA group, salt, and seasoning powder to total dietary Na intake.

Results
Participants were 44 years old on average and were mainly women (91.4%). The participation compliance in the workshops was 69.5%. After 3 months, there was a Na intake mean reduction of 976 mg. There was also a reduction in the excreted urinary Na of 325 mg per day.

Conclusion
A positive level of involvement in this program had a direct influence on dietary habits to lower Na consumption.
Preclinical comparison of [177Lu]Lu-rhPSMA-10.1 and [177Lu]Lu-rhPSMA-10.2 for endoradiotherapy of prostate cancer: biodistribution and dosimetry studies
Authors: Wurzer Alexander , De Rose Francesco , Fischer Sebastian , Schwaiger Markus , Weber Wolfgang , Nekolla Stephan , Wester Hans-Jürgen , Eiber Matthias , D’Alessandria Calogero 
Published: February 2024

Abstract
Background
Radiohybrid PSMA-targeted ligands (rhPSMA) have been introduced as a novel platform for theranostic applications. Among a variety of rhPSMA-ligands developed for radioligand therapy, two stereoisomers [177Lu]Lu-rhPSMA-10.1 and -10.2 have been synthesized and initially characterized in preclinical experiments with the aim to provide an optimized binding profile to human serum albumin, a reduction of charge, and thus accelerated kidney excretion, and unaffected or even improved tumor uptake. As both isomers showed similar in vitro characteristics and tumor uptake at 24 h post injection in tumor bearing mice and in order to identify the isomer with the most favorable pharmacokinetics for radioligand therapy, we carried out in-depth biodistribution and dosimetry studies in tumor-bearing and healthy mice.

Results
rhPSMA-10.1 and -10.2 were radiolabeled with lutetium-177 according to the established procedures of other DOTA-based PSMA ligands and displayed a high and comparable stability in all buffers and human serum (> 97%, 24 h). Biodistribution studies revealed fast clearance from the blood pool (0.3–0.6%ID/g at 1 h) and other background tissues within 48 h. Distinctive differences were found in the kidneys, where [177Lu]Lu-rhPSMA-10.1 displayed lower initial uptake and faster excretion kinetics compared to [177Lu]Lu-rhPSMA-10.2 expressed by a 1.5-fold and ninefold lower uptake value at 1 h and 24 h in healthy animals, respectively. Tumor uptake was comparable and in the range of 8.6–11.6%ID/g for both isomers over 24 h and was maintained up to 168 h at a level of 2.2 ± 0.8 and 4.1 ± 1.4%ID/g for [177Lu]Lu-rhPSMA-10.1 and [177Lu]Lu-rhPSMA-10.2, respectively.

Conclusion
Our preclinical data on biodistribution and dosimetry indicate a more favorable profile of [177Lu]Lu-rhPSMA-10.1 compared to [177Lu]Lu-rhPSMA-10.2 for PSMA-targeted radioligand therapy. [177Lu]Lu-rhPSMA-10.1 shows fast kidney clearance kinetics resulting in excellent tumor-to-organ ratios over a therapy relevant time course. Meanwhile, [177Lu]Lu-rhPSMA-10.1 is currently being investigated in clinical phase I/II studies in patients with mCRPC (NCT05413850), in patients with high-risk localized PC (NCT06066437, Nautilus Trial) and after external beam radiotherapy (NCT06105918).
Electronic adaptation and danish cross-cultural translation of PEmb-QoL and VEINES-QoL/Sym for patients with venous thromboembolism
Authors: Lindegaard Stine Foged , Højen Anette Arbjerg , Rolving Nanna 
Published: February 2024

Abstract
Purpose
Most patient-reported outcome (PROs) used in thrombosis research and clinical practice are delivered using technology like online questionnaires. However, only few have undergone formal electronic adaptation from paper to digital versions, threatening the validity and reliability of the PROs. The present study aimed to perform an electronic adaption and cross-cultural translation of two PROs measuring health-related quality of life in a Danish cohort of patients with venous thrombosis (VTE), specifically the VEINES-QoL/Sym questionnaire and the PEmb-QoL questionnaire.

Methods
The electronic adaption and cross-cultural translation processes followed the international guidelines recommended by ISPOR. The migration of the questionnaires from paper to electronic versions was conducted in the Research Electronic Data Capture (REDCap). Following approval of the electronically adapted and translated versions, a pretest of the questionnaires was performed by cognitive interviewing patients with VTE recruited from a hospital setting.

Results
Nine men and ten women between the age of 19 and 73 years participated in cognitive interviews. The questionnaires were successfully adapted from paper to electronic versions, and during the migration process only a few modifications to the content and format were made. Most comments were related to technicalities, e.g. touch functions and checkboxes. The cross-cultural translation of both questionnaires was satisfactory, as only minor rephrasing was required.

Conclusions
The original and Danish version of VEINES-QoL/Sym and PEmb-QoL were successfully adapted into electronic versions and are ready to share for REDCap users. Furthermore, the Danish versions of the two questionnaires have shown satisfactory face validity.
Ethnozoological importance of Eisenia fetida and experimental validation of its anticancer activity in ascites Dalton’s lymphoma (DL) bearing mice
Authors: Borah Manash Pratim , Prasad Surya Bali 
Published: February 2024

AbstractEisenia fetida, commonly known as the red earthworm, holds significant ethnozoological importance due to its traditional use in various cultures as a medicinal agent. This study aims to explore the potential anticancer effects of Eisenia fetida paste (EFP) and evaluate its therapeutic efficacy in mice with ascites Dalton's lymphoma (DL). The EFP extract demonstrated a significant antitumour effect, possibly by initiating programmed cell death and mitochondrial changes in the tumour cells. The viability of tumour cells exhibited a reduction over time due to EFP treatment. Comparative analysis with the reference drug cisplatin revealed that EFP exhibited fewer or no adverse effects on mutagenicity, hepatotoxicity, and nephrotoxicity in tumour-bearing hosts. EFP treatment was found to show progressive increase in the quantity of apoptotic DL cells over time suggesting a time-dependent impact on the induction of apoptosis in the treated groups. These results imply that EFP might serve as a safer substitute for cancer treatment and hold promise for developing new and improved therapeutic strategies against cancer. The main implication of the study is that EFP might serve as a safer substitute for cancer treatment. It suggests a promising avenue for developing new and improved therapeutic strategies against cancer, with the potential to enhance treatment outcomes while minimising adverse effects.
Graphical abstract
Using web-based, guided self-help to bridge the waiting time for face-to-face out-patient treatment for bulimic-spectrum disorders: randomised controlled trial
Authors: Vollert Bianka , Yim See Heng , Görlich Dennis , Beintner Ina , Gordon Gemma , Musiat Peter , Schmidt Ulrike , Jacobi Corinna 
Published: February 2024

Background
Although effective treatments for bulimic-spectrum eating disorders exist, access is often delayed because of limited therapist availability and lengthy waiting lists. Web-based self-help interventions have the potential to bridge waiting times for face-to-face treatment and overcome existing treatment gaps.

Aims
This study aims to assess the effectiveness of a web-based guided self-help intervention (everyBody Plus) for patients with bulimia nervosa, binge eating disorder and other specified feeding and eating disorders who are waiting for out-patient treatment.

Method
A randomised controlled trial was conducted in Germany and the UK. A total of 343 patients were randomly assigned to the intervention ‘everyBody Plus’ or a waitlist control condition. The primary outcome was the number of weeks after randomisation until a patient achieved a clinically relevant improvement in core symptoms for the first time. Secondary outcomes included eating disorder attitudes and behaviours, and general psychopathology.

Results
At 6- and 12-month follow-up, the probability of being abstinent from core symptoms was significantly larger for the intervention group compared with the control group (hazard ratio: 1.997, 95% CI 1.09–3.65; P = 0.0249). The intervention group also showed larger improvements in eating disorder attitudes and behaviours, general psychopathology, anxiety, depression and quality of life, compared with the control group at most assessment points. Working alliance ratings with the online therapist were high.

Conclusions
The self-help intervention everyBody Plus, delivered with relatively standardised online guidance, can help bridge treatment gaps for patients with bulimic-spectrum eating disorders, and achieve faster and greater reductions in core symptoms.
IL-6 predicts non-suicidal self-injury over 3 months in high-risk adolescents
Authors: Bai Sunhye , Asarnow Joan R. , Babeva Kalina N. , Irwin Michael R. 
Published: February 2024

Background
Suicide is the second leading cause of death in 12- to 17-year-old adolescents in the USA. Research on biological mechanisms contributing to self-harm risk that could be targeted in treatment could help to prevent suicide and self-harm episodes.

Aims
We aimed to evaluate whether markers of inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), predict self-harm over 3 months within a sample selected for elevated suicide/self-harm risk at project entry.

Method
Fifty-one adolescents aged 12–19 years selected for elevated suicide/self-harm risk completed three clinical interviews about suicide attempts and non-suicidal self-injury, 3 months apart. At baseline and 3 months, youth also provided blood samples, from which we assayed levels of IL-6 and CRP.

Results
Using generalised mixed models, we found that greater levels of IL-6 predicted more self-harm episodes (odds ratio [OR] = 3.3, 95% CI: 1.1, 10.0) and specifically, non-suicidal self-injury (OR = 3.5, 95% CI: 1.1, 11.2), over 3 months.

Conclusions
The study findings increase our understanding of whether and how inflammation may be implicated in risk of self-harm. IL-6 may be a viable biological marker of short-term risk for self-harm.
Effects of rainbow gravity on an electron confined to a triangular well and a periodic potential
Authors: Bakke K. , Muniz C. R. 
Published: February 2024

Abstract
We investigate quantum effects concerning the modification of the background via rainbow gravity on an electron. We employ the nonrelativistic approximation of the Dirac equation to analyze these effects in depth. We initially study the interaction between an electron and a uniform electric field, by exploring confinement of the particle to a triangular potential well. We find systematic alterations in the energy levels reliant on the rainbow parameter ϵ. Additionally, we investigate a particle in a periodic potential resembling a ring. We also find consistent alterations in energy levels due to changes in the background via rainbow functions. As in the previously analyzed scenario, the larger the rainbow parameter, the lower the obtained energy levels. These findings underscore a systematic influence of modified gravity on particle dynamics in quantum scenarios.
More Rapid Bone Mineral Density Loss in Older Men With Diabetes: The Osteoporotic Fractures in Men (MrOS) Study
Authors: Tramontana Flavia , Napoli Nicola , Litwack-Harrison Stephanie , Bauer Douglas C , Orwoll Eric S , Cauley Jane A , Strotmeyer Elsa S , Schwartz Ann V 
Published: February 2024

Abstract

Context
Type 2 diabetes mellitus is associated with more rapid bone loss in women, but less evidence is available for men or those with prediabetes.

Objective
To determine whether bone loss rate is affected by diabetes status in older men, we analyzed data from the Osteoporotic Fractures in Men (MrOS) study.

Methods
The multisite MrOS study enrolled 5994 men aged ≥ 65 years. Diabetes status was defined by self-report, diabetes medication use, or elevated fasting serum glucose at baseline. Hip bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DXA) at baseline and a follow-up visit after 4.6 ± 0.4 years. This analysis included 4095 men, excluding those without follow-up DXA or with unknown diabetes status. Changes in hip BMD in participants with normoglycemia (NG), prediabetes, or type 2 diabetes, excluding thiazolidinedione (TZD) users, were evaluated using generalized linear models (GLM). Diabetes medication use and BMD loss among those with type 2 diabetes were also evaluated with GLM.

Results
In adjusted models, hip BMD loss was greater in men with type 2 diabetes (− 2.23%; 95% CI: −2.54 to −1.91; P &lt; .001) but not in men with prediabetes (−1.45%; 95% CI −1.63 to −1.26; P = .33) compared with NG (−1.57%; 95% CI −1.73 to −1.41). Among men with type 2 diabetes, TZD, insulin, and sulfonylurea use were associated with greater hip BMD loss.

Conclusion
Men with type 2 diabetes, but not prediabetes, experienced accelerated bone loss compared to participants with normoglycemia. More rapid bone loss predicts increased risk of fractures and mortality in broader populations.