bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up
Authors: Martínez Isabella , Oyonarte Rodrigo , Concha Guillermo , Brizuela Claudia 
Published: April 2024

Abstract

Background
Regenerative endodontic procedures (REPs) are innovative treatments aimed at restoring damaged dental structures. However, the effect of orthodontic movement on REP-treated teeth is not well understood and may have significant long-term consequences. This study aimed to evaluate the impact of orthodontic movement on a mature permanent tooth associated with dens invaginatus that has undergone a regenerative endodontic procedure (REP).
Case presentation:
This case involves a preliminary investigation into the effects of orthodontic movements on a mature REP-treated tooth. This could have the potential to enrich our collective understanding and guide treatment planning, leading to the development of clinical guidelines. This report describes the case of a 13-year-old male with a noncontributory medical history who presented with pulp necrosis and a chronic apical abscess (tooth number 2.2). Following REP according to the American Association of Endodontists' guidelines, the patient began orthodontic treatment after 9 months. Subsequent follow-ups at 9 months, 2 years, and 3 years post-REP revealed an asymptomatic state with minimal cervical discolouration and diminished cold sensitivity. Radiographic analyses revealed periapical healing, dentin wall thickening, and consistent root length. The treated tooth displayed a positive response to both REP and orthodontic treatment, yet further research is necessary to determine the long-term effects of orthodontic forces on REP-treated teeth.
Conclusion
Our findings suggest that orthodontic movement following REPs in mature permanent teeth is feasible and may also act as a protective factor against apical root resorption. Our experience indicates that a 9-month healing period permits successful orthodontic outcomes following REPs. Nonetheless, the predictability of outcomes and the ideal healing period before orthodontic movement is initiated remain to be established.
Contrast-enhanced ultrasound based radiomics model enhances identification of symptomatic carotid plaque
Authors: Wang Tingting , Zhang Ying , Chen Jifan , Fu Yuhan , Yao Jianting , Zhang Rui , Jia Minyue , Wu Qingbiao , Huang Pintong 
Published: April 2024

Abstract

Background:We aimed to identify the most valuable variables in multi-modal ultrasound technologies and compare the performance of radiomics models in detecting symptomatic carotid plaques.Methods:From August 2013 to April 2021, we retrospectively enrolled 112 carotid plaque patients and randomly divided them into training and validation cohorts at a 3:1 ratio. A traditional model (T model) was built using independently significant variables from multivariate analysis of clinical and multi-modal ultrasound characteristics. Radiomics models based on conventional ultrasound, contrast-enhanced ultrasound (CEUS), and a combined approach (USR, CEUSR, and US-CEUSR) were then developed. Combined with T model, three incorporated models (TUSR, TCEUSR, and TUS-CEUSR) were established. Model performance was assessed using area under the receiver operating characteristic curve (AUC) and decision curve analysis.Results:Only intraplaque contrast enhancement from CEUS modality was independently associated with clinical symptoms [odds ratio = 3.750; 95% confidence interval (CI), 1.403–10.881;p= 0.010] and was used to construct the T model, which achieved an AUC of 0.583 (95% CI, 0.390–0.776) in the validation cohort. The CEUSR model had an AUC of 0.813 (95% CI, 0.626–0.957), surpassing the T model (p< 0.001). The USR model's AUC was 0.663 (95% CI, 0.427–0.866). Notably, the CEUSR model outperformed the USR model (p= 0.043). Other integrated models didn't significantly surpass the CEUSR model.Conclusion:Intraplaque contrast enhancement, a qualitative variable by CEUS, is an independent risk factor for symptomatic carotid plaques, and radiomics features from CEUS can effectively predict symptomatic carotid plaques.
Impact of the Timed and Targeted Counselling Model on Maternal Health Continuum of Care Outcomes in Northern Uganda: Protocol of a Quasi-Experimental Study
Authors: Zibugu Douglas , Gubbels Jessica S , Asiimwe John Bosco , Sanne Gerards 
Published: April 2024

Abstract

Background
About 287,000 women died during and following pregnancy and childbirth in 2020 worldwide. Almost 95% of all these maternal deaths occurred in low and lower middle-income countries, and most could have been prevented. The timed and targeted counselling behavioural change approach, implemented by community health workers targeting mothers and their male caregivers (e.g., their husband, brother or father), is expected to positively impact overall maternal health. This study aims to assess the impact of timed and targeted counselling on the continuum of care outcomes in Northern Uganda.
Methods
This study will employ a cross-sectional quasiexperimental design, with retrospective data collection comparing an intervention group to a control group. The main outcome measures are antenatal care, place of delivery and postnatal care. The study employs a two-stage sampling procedure purposively selecting the Oyam District, including two strata of subcounties: Aber (Treatment) and Otwal (Control). The required sample size consisted of 456 mothers per treatment group (i.e., 912 in total). The study participant selection criterion will be mothers who have given birth between the 2nd the 12th month of the study area. Propensity score matching will be used to control for confounders and improve causal inference. Sensitivity analysis will be carried out to test the robustness of the results to unmeasured confounders in the propensity score match. After regression, postmodel estimation tests such as the Akaike information criterion, the link test and the Wald test will be carried out.
Discussion
This study is the first to evaluate the impact of timed and targeted counselling on maternal health in Northern Uganda. These findings will be used to modify the implementation of the timed and targeted counselling approach, thereby enhancing its impact, efficiency, and effectiveness.
Protocol Registration
This study protocol was registered under the Makerere University School of Social Sciences Research Ethics Committee (MAKS REC) under MAKSSREC 10.2023.710 (registration date 30th of November 2023) and the Uganda National Council for Science and Technology (UNCST HS3826ES).
Exploring the Anti-inflammatory and Anti-Arthritic Potential of Malus peel Phenolics: A comprehensive comparative analysis of Royal delicious, Delicious, Golden delicious, andMaharaji Cultivars from Kashmir, India
Authors: Shah Ashfaq Ahmad , Pandey Neha , Bachheti Rakesh Kumar , Rai Nishant , Gupta Amit 
Published: April 2024

Abstract
The aim of the current investigation was to reveal whether the peel phenolics of three red-colored ("Royal Delicious", "Delicious", "Maharaji") and one yellow-colored ("Golden Delicious") malus variety might have a differential tendency with regard to inflammation and arthritis, as these varieties indigenous to Kashmir have not yet been exploited for the same. The comparative assessment of the immunomodulatory properties of decoctures, prepared by amalgamating the extracts of different polar menstruums, was analyzed by subjecting them to in vitro assays of inflammation and arthritis. In the decoctures, the presence of carboxylic acids, poly-hydroxy compounds, aromatic rings, alcohols, alkenes, ethers, nitro compounds, phenols, hydrogen-bonded alcohols, and esters was demonstrated by FTIR. All the FTIR spectra correlate to the functionality of phenolic and polyphenolic compounds deemed to be present in malus varieties. All the peel decoctions showed significant inflammation suppressive and anti-arthritic efficacy, in a dose-dependent fashion. With the goal to treat oxidative stress-related, inflammatory, and arthritic illnesses, the present research assigns the greatest pharmacological precedence to the bioactive compounds extracted on a polarity premise from peels of Malus domestica var Maharaji.
First record of Telenomus dilophonotae (Hymenoptera: Scelionidae), parasitizing eggs of Erinnyis ello (Lepidoptera, Sphingidae) in western Paraná, Brazil, with molecular characterization and records of occurrences
Authors: Wengrat Ana P. G. S. , Carvalho Leidiane Coelho Carvalho Coelho , Pietrowski Vanda , Schoeninger Karine , Costa Valmir Antonio , Johnson Norman F. 
Published: April 2024

Abstract

There are few records for Telenomus dilophonotae Cameron, 1913 (Hymenoptera: Scelionidae) from South America. In Brazil, the first occurrence was reported in Bahia in rubber crops, Hevea brasiliensis (Willd. ex Adr. de Juss.) Muell. - Arg., there parasitizing eggs of Erinnyis ello Linnaeus, 1758 (Lepidoptera, Sphingidae). It was also found parasitizing the same host in cassava, Manihot esculenta Crantz (Euphorbiaceae). This is the first record of occurrence of T. dilophonotae in the state of Paraná, parasitizing eggs of E. ello in areas of cassava production in the western region of Paraná, this being the southernmost record of the species. Here, photographs, the first sequence of DNA-barcode of this species of parasitoid wasp, and a distribution map are provided.
Variable Mass and the Noisy Feynman Propagator in Scalar Fields
Authors: Tameshtit Allan 
Published: April 2024

Abstract

We utilize a mass independent Klein-Gordon equation that is first order in a variable that plays the role of time, the approach taken in parametric time formulations. Using concepts from semigroup evolution, we examine the sign of a noisy Feynman propagator in a quantum field theory, namely, scalar electrodynamics.
Risk factors for wet macular degeneration: a systematic review, with novel insights from the Scottish Heart Health Extended Cohort
Authors: Fitton Catherine A , Quigley Madeleine MR , Belch Jill JF 
Published: April 2024

Abstract

Age-related macular degeneration (AMD) is a major source of vision loss worldwide. This study aims to assess risk factors for wet AMD by two methods: assessing risk factors measured in the Scottish Heart Health Extended Cohort (SHHEC), and to systematically review the literature.
Methods: 18,107 volunteers were recruited to SHHEC between 1984-1995, with risk factor data collected on recruitment. Hospital records were linked to study data up to 2017 and survival analysis used to analyse risk factors and wet AMD. Literature published between 2000-2023 was searched for studies assessing risk factors for wet AMD, resulting in 5503 papers. Following review, 7 studies were included in the systematic review.
Results: Within the SHHEC data, 231 cases of wet AMD are reported. Age (Hazard Ratio (HR) 10.74; 95% Confidence Interval (CI) 5.90-19.56), being female (HR 1.37; 95% CI 1.02-1.84), smoking (HR 1.67; 95% CI 1.28-2.18), and a serum glucose > 5.32mmol/l (HR 1.62; 95% CI 1.09-2.42) were significantly associated with an increased risk of wet AMD. Vitamin K (HR 0.56; 95% CI 0.38-0.83), and Apolipoprotein B (HR 0.65; 95% CI 0.43-0.99) were associated with a decreased risk of wet AMD.
Within the systematic review, there was evidence that systolic blood pressure, pulse pressure, high BMI, alcohol intake, high C-reactive protein, high serum triglycerides and smoking may be associated with an increased risk of wet AMD; however the studies provide mixed evidence and no conclusive results can be drawn.
Value of integrating three-dimensional technology with the Sampaio collecting system fractal theory for percutaneous nephrolithotomy treatment of difficult renal calculi
Authors: ZHANG Jiamo , ZHANG Xuan , CHEN Jiangchuan , LI Changlong , CHENG Honglin 
Published: April 2024

Abstract
Objective
To investigate the safety and efficacy of percutaneous nephrolithotomy (PCNL) in the treatment of complicated renal calculi by integrating three-dimensional (3D) computed tomography (CT) reconstruction with the Sampaio collecting system fractal theory.
Methods
Sixty-four consecutive patients with complex kidney calculi who underwent PCNL between January 2019 and October 2023 were retrospectively analyzed and divided into an experimental group (3D printing) and control group (CT imaging) according to their willingness to pay for 3D imaging. Both groups underwent preoperative CT urography. The Digital Imaging and Communications in Medicine data of the experimental group from CT imaging were used for 3D reconstruction and model printing. Then, the Sampaio collecting system fractal theory was used to design the puncture channel and develop a surgical strategy.
Results
The 3D-printed models of the experimental group successfully displayed the Sampaio collecting system fractal theory. There was no significant difference in the baseline parameters between the groups. Compared with the control group, the experimental group exhibited significant improvements in the puncture time, number of puncture needles, number of puncture channels, target calyx consistency, number of first puncture channels, and stone clearance. There were no significant differences in the total operative time, decrease in the hemoglobin level, length of hospital stay, and postoperative complications between the groups.
Conclusions
Integration of 3D technology with the Sampaio collecting system fractal theory can enhance the preoperative evaluation and planning of percutaneous renal access. This approach allows a more precise method of PCNL for treating intricate renal calculi.
Signature genomic traits of the core and accessory genome of Vibrio Cholerae O1 drive lineage transmission and disease severity
Authors: Maciel-Guerra Alexandre , Babaarslan Kubra , Baker Michelle , Rahman Aura , Hossain Maqsud Muhammad , Sadique Abdus , Alam Jahidul , Uzzaman Salim , Sarker Mohammad Ferdous Rahman , Sultana Nasrin , Khan Ashraful Islam , Begum Yasmin Ara , Afrad Mokibul Hassan , Senin Nicola , Habib Zakir Hossain , Shirin Tahmina , Qadri Firdausi , Dottorini Tania 
Published: April 2024

Abstract

In Bangladesh, Vibrio cholerae lineages are undergoing genomic evolution, causing pandemics and outbreaks with increased virulence, resistance, spreading ability and disease severity. However, our understanding of the genomic determinants influencing transmission and disease severity patterns, as well as their interplay, remains incomplete. Here, we developed a computational framework based on machine-learning, genome scale metabolic modelling (GSSM) and 3D structural analysis, to identify V. cholerae signatures genomic traits linked to lineage transmission dynamics and disease severity. We analysed isolates collected from in-patients across six regions in Bangladesh from 2015 to 2021, and uncovered a core set of accessory genes, coding, and intergenic SNPs uniquely present in the most recent dominant lineage and underlying lineage transmission, with virulence, motility, colonization, biofilm formation, acid tolerance and bacteriophage resistance functions. Furthermore, we uncovered the existence of a strong correlation between a core set of V. cholerae genomic determinants and disease severity patterns (diarrhoeal duration, number of stools, abdominal pain, vomit, and dehydration). A subset of these determinants overlapped with those driving lineage transmission dynamics. Through GSMM and 3D structure analysis, we inferred the mechanistic bases underlying their selection and unveiled a complex interplay between transcription regulation, protein interactions and stability, and metabolic networks leading to severe symptoms. These connections influence lifestyle adaptation, intestinal colonization, oxidative stress and acid tolerance through modulation of ribosome, fatty acid and peptide biosynthesis, bacterial efflux systems, virulence, and resistant genes. Our computational framework allows to uncover signature traits which can provide insights for advancing therapeutics and developing targeted interventions to mitigate cholera spread.
Green synthesis, characterization, and biomedical applications of Iron nanoparticles synthesized from the alcoholic extract of the aerial part of Micromeria biflora (Buch. Ham. ex D.Don) Benth
Authors: Rauf Abdur , Ibrahim Muhammad , Ahmad Zubair , Muhammad Naveed , Al-Awthan Yahya S. , Bahattab Omar S. , Rami Saeed Hameed , Bawazeer Saud , Ullah Imran , Thiruvengadam Rekha , Thiruvengadam Muthu 
Published: April 2024

Abstract

This study explored the synthesis and characterization of iron nanoparticles (NPs) using Micromeria biflora extract. The rapid reduction of iron ions, evidenced by a distinct color change, signifies an efficient interaction, leading to successful NPs formation. UV-visible spectroscopy confirmed the synthesis, revealing an absorption peak at 295 nm that intensified over time. Fourier Transform Infrared (FTIR) spectroscopy demonstrates phytochemical involvement. Field-Emission Scanning Electron Microscopy (FESEM) images displayed cuboctahedron-shaped NPs with various facet formations, which are crucial for diverse applications. DISCUS package was used to simulate the shape and decorate the surface with organic molecules obtained from the extract. Energy Dispersive X-ray Spectroscopy (EDS) was used to confirm the elemental composition. Additionally, potential applications, including enzyme effects and sedative and anti-inflammatory properties, were explored. The extract and NP showed anticancer effects against MDR2780AD cell lines, with IC50 values of 1.99 and 0.91 respectively. The tested Iron NPs showed 92.22, 76.22, and 88.23% inhibitory effects against urease, CA-II, and XO, respectively. The maximum percentage analgesic effects of the extract (100 mg/kg) and NPs (10 mg/kg) were 65 and 82, respectively. Maximum anti-inflammatory effect was observed at the third hour of treatment. The anti-inflammatory effect of NP (90%) was superior to that of the extract (60%).
Vibration characteristics and machining performance of carbon fiber reinforced shaft in poor rigidity machining tool system
Authors: Ma Zheng , Cai Chongyan , Yin Youkang , Dang Jiaqiang , Ming Weiwei , An Qinglong , Chen Ming , Liu Gang , Li Junli 
Published: April 2024

Abstract

Carbon fiber reinforced polymer (CFRP) materials have gained significant attention in the machining industry due to their exceptional strength-to-weight ratio and vibration characteristics. In the poor rigidity machining tool system, such as plunge milling, deep drilling and boring, the large overhanging shaft increases the requirement of chatter stability. In this study, a solution of carbon fiber reinforced shaft was proposed for the poor rigidity machining tool system. The vibration characteristic model was established by theoretical calculation, FE analysis and modal testing. The relationship between fiber arrangement and vibration characteristics was precisely described, and the optimization scheme of fiber reinforcement was proposed considering both the theoretical analysis and procedure technique. The machining performance of the optimal HSS-CFRP shaft was compared with that of the traditional HSS shaft in the same tool system. Main aspects that significantly affect the machining performance were thoroughly evaluated, including tool weight, energy consumption, dynamic characteristics and chatter stability. The effect of fiber reinforcement was fully discussed, which provided a reliable solution for the poor rigidity machining system and other potential applications with large overhanging shaft.
New insights into changes in ocular structural parameters in a simulated hypobaric hypoxia plateau environment
Authors: Wang Yuchen , Guo Anqi , Yu Xinli , Liu Yihe , Wang Zesong , Xie Jiaxing , Zhou Xinzuo , Liu Siru , Li Jiaxi , Zhou Chengkai , Li Yuanhong , Sun Chao , Zhang Jing , Liu Ziyuan , Li Xuemin , Ding Li 
Published: April 2024

Abstract

Purpose
High altitude is the main area for human exploration, and human eye is an important organ for obtaining visual signals. The changes of eye structure and function caused by hypobaric hypoxia environment need to be clarified.
Methods
Measurements were taken at five altitudes (1: ground; 2: 3500m; 3: 4000m; 4: 4500m; and 5: end of experiment). Refractive values were measured with the IOL Master (Carl Zeiss Shanghai Co. Ltd.). Data analysis was performed using the Kolmogorov–Smirnov (K-S) test, paired sample T-test, and Wilcoxon test.
Results
Subjects’ axial length (AL) increased with altitude, peaking at 4500m, then decreased. Significant differences in AL were observed across altitudes (p < 0.05), except between 2 and 5, and 3 and 5. Central corneal thickness (CCT) thickened then thinned with elevation changes, significantly thicker at altitudes 2–5 compared to the baseline (p < 0.05). Lens thickness (LT) followed a similar pattern, increasing up to altitude 4, then decreasing at 5. Correlations were found between AL and LT at altitudes 1 (r = 0.375, p < 0.05) and 5 (r = 0.341, p < 0.05), and between AL and CCT at altitude 4 (r = 0.337, p < 0.05), but not elsewhere. No significant relationship was observed between LT and CCT.
Conclusions
As altitude increases and the degree of acute low-pressure hypoxia worsens, the refractive parameters such as AL, CCT, and LT are altered, which could potentially affect the pilot's visual function after acute hypoxia, further affecting the pilot's information acquisition and decision-making during driving and posing a threat to flight safety.
Genome-wide identification and analysis of bZIP gene family reveal their roles under salt stress in Suaeda australis
Authors: Qu Yinquan , Wang Ji , Gao Tianxiang , Qu Caihui , Mo Xiaoyun , Zhang Xiumei 
Published: April 2024

Abstract

Background
Suaeda australis is one of typical halophyte owing to high levels of salt tolerance. In addition, the bZIP gene family assumes pivotal functions in response to salt stress. However, there are little reports available regarding the bZIP gene family in S. australis.
Results
In this study, we successfully screened 44 bZIP genes within S. australis genome. Subsequently, we conducted an extensive analysis, encompassing investigations into chromosome location, gene structure, phylogenetic relationship, promoter region, conserved motif, and gene expression profile. The 44 bZIP genes categorized into 12 distinct groups, exhibiting an uneven distribution among the 9 chromosomes of S. australis chromosomes, but one member (Sau23745) was mapped on unanchored scaffolds. Examination of cis-regulatory elements reveled that bZIP promoters were closely related to anaerobic induction, transcription start, and light responsiveness. Expression patterns analyses clearly discovered the role of several SabZIPs including Sau08107, Sau08911, Sau11415, Sau16575, and Sau19276, which showed higher expression levels in higher salt concentration than low concentration and obviously response to salt stress. These expression patterns were corroborated through RT-qPCR analysis.
Conclusions
Our findings offer valuable insights into the evolutionary trajectory of the bZIP gene family in S. australis and shed light on their roles in responding to salt stress. In addition to fundamental genomic information, these results would serve as a foundational framework for future investigations delving into the regulation of salt stress responses in S. australis.