bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel frameless LINAC radiosurgery solution for uveal melanoma
Authors: Cappelli Louis , Khan Mehak , Vemula Sudheshna , Hum Christina , Liu Haisong , Yu Yan , Chen Yingxuan , Zhang Yechi , Sharif Muhammad , Shi Wenyin 
Published: March 2024

IntroductionRadiation treatment has replaced enucleation as an organ-preservation treatment for patients with uveal melanoma (UM). We developed a novel non-invasive, frameless LINAC based solution for fractionated stereotactic radiosurgery (fSRS) treatment.MethodsWe designed and constructed the a stereotactic ocular localization box that can be attached and indexed to a stereotactic LINAC tabletop. It contains adjustable LED lights as a gaze focus point and CCD camera for monitoring of the patient’s eye position. The device also has 6 infrared spheres compatible with the ExacTRAC IGRT system. Treatment plans were developed using iPLAN Dose version 4.5, with conformal dynamic arcs and 6MV photon beam in flattening filter free mode, dosed to 50Gy in 5 fractions. During treatment, patients were instructed to stare at the light when a radiation beam is prepared and ready for delivery. Eye movement was tracked throughout treatment. Residual setup errors were recorded for evaluation.ResultsThe stereotactic ocular localization box was 3D-printed with polylactic acid material and attached to the stereotactic LINAC tabletop. 10 patients were treated to evaluate the feasibility, tolerability and setup accuracy. Median treatment time for each arc is 17.3 ± 2.4 seconds (range: 13.8-23.4). After ExacTRAC setup, the residual setup errors are -0.1 ± 0.3 mm laterally, -0.1 ± 0.3 mm longitudinally, and 0 ± 0.2 mm vertically. The residue rotational errors are -0.1 ± 0.3 degree pitch, 0.1 ± 0.2 degree roll, and 0 ± 0.2 degree couch rotation. All patients received treatment successfully.ConclusionWe successfully developed a novel non-invasive frameless mask-based LINAC solution for SRS for uveal melanoma, or other ocular tumors. It is well tolerated with high set up accuracy. Future directions for this localization box would include a multi-center trial to assess the efficacy and reproducibility in the fabrication and execution of such a solution for UM therapy.
Misleading clinical and imaging features in atypical aggressive angiomyxoma of the female vulvovaginal or perianal region: report of three cases and review of the literature
Authors: Zhang Ling , Liu Rong , Peng Jian 
Published: March 2024

ObjectivesAggressive (deep) angiomyxoma (AAM) is a rare mesenchymal tumor that typically originates from the vulvovaginal region, perineum, and pelvis in adult women. The objective of this case report and literature review is to comprehensively analyze the clinical, imaging, and pathological characteristics of atypical AAM in the female lower genital tract and pelvic floor in order to minimize preoperative misdiagnosis or missed diagnosis and ultimately optimize the clinical management strategy.MethodsThe data of three cases with atypical AAM, which demonstrate similarities with other lesions observed in the female lower genital tract over the past 1.5 years, were retrospectively described. This description included clinical management, images and reports of ultrasonography (US) and magnetic resonance imaging (MRI), clinicopathological features, follow-up, and outcomes. In the Discussion section, a review of the literature on MEDLINE (PubMed) and Web of Science from the past 50 years was conducted.ResultsThe three cases all underwent preoperative ultrasonography, and two of them also underwent preoperative MRI examination. Complete resection of the lesions was performed in all three cases, followed by postoperative pathological examination. The histopathology of these three cases revealed invasive angiomyxoma, as confirmed by immunohistochemical staining, which demonstrated positive expression of desmin, vimentin, estrogen, and progesterone receptors. The patients experienced a smooth postoperative recovery. Ultrasound had a diagnostic accuracy rate of 100% (3/3) for locating and determining the extent of the lesions; however, its specific diagnostic accuracy rate for identifying the pathological type was only 33% (1/3). In contrast, MRI had a diagnostic accuracy rate of 100% (2/2) for locating and determining the extent of lesions but did not show any specific diagnostic accuracy for identifying the pathological types.ConclusionsOur findings indicate that even if a vulvovaginal lesion presents with a superficial location, small size, limited scope, and regular shape, suspicion of atypical AAM should arise when palpation reveals toughness, tensility, and deformability under pressure. US reveals a well-defined hypoechoic to anechoic mass with uniformly distributed coarse dot echoes, with or without detectable intratumoral blood flow signal. MRI shows prolonged T1 and T2 signals with inhomogeneous enhancement and evident diffusion restriction on diffusion-weighted imaging (DWI).
A bibliometric analysis of research on pediatric preoperative anxiety (2007–2022)
Authors: Zhong Yue , Gong Huishu , Long Feiyu , Zhou Xingchen , Zhou Jun , Wang Maohua , Peng Tao 
Published: March 2024

ObjectiveThis study aimed to analyze the current state of research on preoperative anxiety in children through CiteSpace, VOSviewer, and the identification of hot spots and frontiers.MethodRelevant data were retrieved from the Web of Science Core Collection using the search terms children and preoperative anxiety. Data were analyzed using VOSviewer (version 1.6.18), CiteSpace (5.7. R5) software, and Scimago Graphica.ResultsA total of 622 articles were published between 2007 and 2022, with an increasing trend over time. Kain, Zeev N. (13; 2.09%) and Dalhousie University (15; 2.41%) were the most influential authors and most prolific institutions, respectively. The United States (121; 19.45%) was the country with the most publications. Pediatric anesthesia (55; 8.84%) had the most publications. High-frequency keywords were categorized into three themes, including nonpharmacologic interventions for preoperative anxiety in children, preoperative medications, and risk factors for anxiety; of these, “predictor” (38; 2016) and “sedative premedication” (20; 2016) were the most studied keywords over the past 6 years. “Distraction” (67; 2019) and “dexmedetomidine” (65; 2019) have been the main areas of interest in recent years.ConclusionResearch on preoperative anxiety in children has been the focus of increasing attention over the past fifteen years, with the majority of publications from high-income countries. This review provides a useful perspective for understanding research trends, hot topics, and research gaps in this expanding field.
Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis
Authors: Scaricamazza Silvia , Nesci Valentina , Salvatori Illari , Fenili Gianmarco , Rosina Marco , Gloriani Michela , Paronetto Maria Paola , Madaro Luca , Ferri Alberto , Valle Cristiana 
Published: March 2024

Background:Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by the degeneration of motor neurons that leads to muscle wasting and atrophy. Epidemiological and experimental evidence suggests a causal relationship between ALS and physical activity (PA). However, the impact of PA on motor neuron loss and sarcopenia is still debated, probably because of the heterogeneity and intensities of the proposed exercises. With this study, we aimed to clarify the effect of intense endurance exercise on the onset and progression of ALS in the SOD1-G93A mouse model.Methods:We randomly selected four groups of twelve 35-day-old female mice. SOD1-G93A and WT mice underwent intense endurance training on a motorized treadmill for 8 weeks, 5 days a week. During the training, we measured muscle strength, weight, and motor skills and compared them with the corresponding sedentary groups to define the disease onset. At the end of the eighth week, we analyzed the skeletal muscle-motor neuron axis by histological and molecular techniques.Results:Intense endurance exercise anticipates the onset of the disease by 1 week (age of the onset: trained SOD1-G93A = 63.17 ± 2.25 days old; sedentary SOD1-G93A = 70.75 ± 2.45 days old). In SOD1-G93A mice, intense endurance exercise hastens the muscular switch to a more oxidative phenotype and worsens the denervation process by dismantling neuromuscular junctions in the tibialis anterior, enhancing the Wallerian degeneration in the sciatic nerve, and promoting motor neuron loss in the spinal cord. The training exacerbates neuroinflammation, causing immune cell infiltration in the sciatic nerve and a faster activation of astrocytes and microglia in the spinal cord.Conclusion:Intense endurance exercise, acting on skeletal muscles, worsens the pathological hallmarks of ALS, such as denervation and neuroinflammation, brings the onset forward, and accelerates the progression of the disease. Our findings show the potentiality of skeletal muscle as a target for both prognostic and therapeutic strategies; the preservation of skeletal muscle health by specific intervention could counteract the dying-back process and protect motor neurons from death. The physiological characteristics and accessibility of skeletal muscle further enhance its appeal as a therapeutic target.
Validity and reliability of the toxic leadership behaviors of nurse managers scale among Chinese nurses
Authors: Zhou Yumei , Lin Juanjuan , Liu Xing , Gao Shuping , Yang Fang , Xu Huili 
Published: March 2024

ObjectivesToxic leadership is increasingly becoming common in the nursing field, but the measurement tools are lacking. Therefore, this study aimed to translate the toxic leadership behaviors of nurse managers (ToxBH-NM) scale into Chinese and test its psychometric properties among Chinese nurses.MethodsThe data for this study were obtained from a cross-sectional survey of 1,195 nurses. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to examine the structural validity of the ToxBH-NM. The following psychometric properties of the scale were assessed: content validity, criterion validity, internal consistency reliability, and test–retest reliability.ResultsThe Chinese version of the ToxBH-NM (C-ToxBH-NM) scale had two dimensions and 30 items. The correlation coefficients between the scores of each item and the total scores were 0762–0.922 (p &lt; 0.001), and the range of the CR determination values of all the items were 8.610–18.998, with statistical significance (p &lt; 0.001). The total content validity index (CVI) was 0.996, the average CVI was 0.996, and the item-level CVI was 0.875–1.000. Two common factors were identified in the EFA, and 81.074% of the variation was explained cumulatively. The CFA showed that all the fitting indexes reached the standard, and the model fit degree was good. When the Chinese version of the Destructive Leadership Scale was used as calibration, the correlation coefficient was 0.378 (p &lt; 0.001). The Cronbach’s alpha coefficients of the overall scale were 0.989 and of the two dimensions were 0.969 and 0.987, respectively, with a split-half reliability of 0.966 and test–retest reliability of 0.978.ConclusionThe research results show that the C-ToxBH-NM scale has good reliability and validity and can be used to evaluate the severity of toxic leadership behavior among nursing managers.
Alignment of Canada's COVID-19 policy response with barriers and facilitators for coping reported by caregivers of youth with developmental delays, disorders, and disabilities
Authors: Katalifos Anna , Elsabbagh Mayada , Yusuf Afiqah , Yamaguchi Sakiko , Scorah Julie , Wright Nicola , Steiman Mandy , Shih Andy , Shikako Keiko 
Published: March 2024

IntroductionThe UNICEF-WHO Global Report on Developmental Delays, Disorders, and Disabilities is an ongoing initiative aimed at increasing awareness, compiling data, providing guidance on strengthening health systems, and engaging country-level partners. Data from its caregiver survey assessing impacts of the COVID-19 pandemic showed that half of youths with developmental delays and disabilities (DDDs) and their caregivers struggled to cope, with a significant portion reporting a lack of supports and difficulty managing the worsening of the child's symptoms in isolation. Governments created service strategies supporting vulnerable groups. Little is known about the alignment between COVID-19 policies for persons with disabilities and their lived experiences. Contextualizing caregivers’ experiences can promote the development of tailored public supports for these families following a public health crisis.MethodsOnline survey data were collected from June-July 2020, leading to a convenience sample of caregivers of youth with DDDs across Canada. Respondents answered two open-ended questions regarding challenges and coping strategies during the pandemic. We conducted a thematic analysis of responses using inductive coding on NVivo software. Overarching codes derived from the dataset were contextualized using an analysis of provincial policies published during the pandemic. Parallels with these policies supported the exploration of families’ and youths’ experiences during the same period.ResultsFive hundred and seventy-six (N = 576) participants answered open-ended questions. Barriers to coping included family mental health issues, concerns about the youths’ regression, challenges in online schooling, limited play spaces, and managing physical health during quarantine. Environmental barriers encompassed deteriorating family finances, loss of public services, and a lack of accessible information and supports. In contrast, caregivers reported coping facilitators, such as family time, outdoor activities, and their child's resilience. Environmental facilitators included community resources, public financial supports, and access to telehealth services. Few COVID-19 policies effectively addressed caregiver-identified barriers, while some restrictions hindered access to facilitators.ConclusionPrioritizing needs of families of youths with DDDs during public health emergencies can significantly impact their experiences and mental health. Enhancing financial benefits, providing telehealth services, and creating inclusive public play spaces are priority areas as we navigate the post-pandemic landscape.
Unveiling transportation disparities: investigating accessibility gaps in metropolitan cities using GIS—a case study of Alexandria, Egypt
Authors: ElDeeb Sally , Abd EL-Baky Rowan Adel , Masoumi Houshmand 
Published: March 2024

IntroductionPublic transportation is essential to reduce pollution and traffic congestion in urban areas. However, in densely populated regions like Alexandria, characterized by high population density and limited road infrastructure, accessibility to diverse transportation options is crucial.MethodsThis study investigates the accessibility of public transportation modes, including railways and buses, and their interaction with informal transit. Questioning if public transportation alone will be sufficient for pedestrians or if the presence of informal transit is crucial, and whether all residents of Alexandria have their rightful accessibility for different transport modes, the goal was to establish an efficient and interconnected transportation network. A survey was conducted in cooperation with Transport for Cairo to investigate all transport routes throughout Alexandria, further using ArcGIS Pro to identify gaps in public transportation coverage.ResultsFindings revealed that public transportation alone is insufficient due to limited bus and railway coverage because of their fixed linear routes. Informal transit, like microbuses, plays a vital role in filling these gaps.DiscussionThe study emphasizes the need for a comprehensive and sustainable transportation network that considers both formal and informal transit. These insights can guide policymakers and urban planners in improving public transportation in Alexandria and similar cities worldwide.
Telestroke activity across Europe; The results of a European Stroke Organization survey
Authors: Ryan Daniel J. , Mueller-Barna Peter , Von Martial Rascha , Corea Francesco , Zvan Bojana , Zivanovic Zeljko , Barlinn Jesicaa , Krasinska-Chavez Milena , Alasheev Andrey 
Published: March 2024

IntroductionTelestroke care is likely not inferior to face-to-face care in acute stroke management while it also provides rural sites with access to specialist expertise. However, little is known about the distribution and activity of telestroke networks across Europe. Consequently, the European Stroke Organization (ESO) Telestroke Committee aimed to address this through an online questionnaire.MethodsThe questionnaire was developed through an unstructured consensus process, ratified by the ESO Executive Committee, and emailed to ESO members.ResultsOf 2,147 ESO members contacted, complete data sets were submitted on 25 networks from 10 countries. Among the 25 networks, the mean number of hubs per network was 1.6 (SD 1.2), and the mean number of spokes was 9 (SD 6.7), with considerable variability observed (range 2–24 spokes/network). All sites used audiovisual communication. The mean telemedicine consultations per year per site was 197 (SD 164). The primary reason for consultation was “diagnostic and triage purposes” in all but one network. The median number of strokes per site was 175 (interquartile range 192), and the mean intervention rate was 12.3% (SD 10; thrombolysis or thrombectomy).ConclusionAt 25 networks, this survey probably underrepresents telestroke activity across Europe, yet it is still the first study to provide a continent-wide geographical footprint and report on activity within the networks. There was considerable variability in network size and activity. Spoke sites reported an acceptable intervention rate of 12.3%. This percentage compares favorably with national data from European countries and suggests telestroke care supports reasonable intervention rates.
Le lac Titicaca bolivien : analyse ethnographique pour penser le désordre environnemental au prisme des savoirs scientifiques et autochtones
Authors: Blanc Ansari Jordie 
Published: March 2024

Cet article présente une enquête de terrain, réalisée de 2017 à 2019, portant sur les enjeux socio-environnementaux du lac Titicaca en Bolivie. Frontalier entre le Pérou et la Bolivie, le lac est à la fois un axe de navigation, une ressource pour l’alimentation en eau, un haut lieu d’attraction touristique et un patrimoine naturel et culturel d’exception. Les différents acteurs (société civile, politiques
publiques, coopérations internationales, scientifiques) luttent contre la détérioration du lac. Or, les activités de préservation de
la ressource lacustre se heurtent bien souvent aux décisions des acteurs territoriaux et sont soumises aux stratégies des acteurs politiques et des bailleurs de fonds. Nous exposerons les différents facteurs de contamination de la ressource liés notamment aux
pressions touristiques, au manque de gestion des eaux usées et à l’urbanisation afin d’interroger ce désordre environnemental. Nous analyserons ces problématiques écologiques à partir des expertises scientifiques réalisées par l’Institut de Recherche pour le
Développement et l’Université Mayor de San Andres ainsi qu’à travers le regard des acteurs locaux. Cette mise en perspective des savoirs nous amènera à questionner la manière dont les mythes, les croyances et les rituels permettent de rationaliser ces enjeux. Quels sont les catégories de perception et les imaginaires que les acteurs locaux projettent sur la nature, sur la pollution, sur le changement climatique ?
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Authors: Taufiqurrahman Moh. 
Published: March 2024

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From Local to Globe: The Representation of Local Culture in An Undergraduate EFL Students’ Textbook
Authors: Humairoh Mega Fariziah Nur , Riska Hanum Kurnia 
Published: March 2024

Given the wide variety of circumstances in which English is being used globally, the role of local culture in teaching English as a Foreign Language (EFL) is a challenging one. Based on the sociocultural viewpoint that language use is dynamic and context-dependent, this article is aimed to investigate the insertion of cultural values in the English textbook that is suitable and practical for undergraduate students. This developmental research employed Preffers model which consists of six stages: Identify the problem, describe the objectives, design & develop the artifact, test the artifact, evaluate testing results, and communicate the testing result. The sample of this study was 15 students of undergraduate students who is taking the English course. Results of an analysis of six sets of ELT textbooks that are distributed extensively and their cultural content are given. The validity test was done by three expert validators. It demonstrated the mean 86.7 and categorized as valid. Then, the practicality test showed a percentage 76.8% And also categorized as good practicality. Our result can be concluded that the developed English textbook is suitable, practical and beneficial for students. We further recommend using this textbook for teaching English.