bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained beneficial hemodynamic effects of low transdermal nitroglycerin doses compared with placebo in patients with congestive heart failure
Authors: Bolognese L. , Sarasso G. , Rognoni G. , Makmur J. , Fornaro G. , Perucca A. , Rossi P. 
Published: February 2009

AbstractIn an attempt to resolve some of the controversies concerning the dose requirements and duration of effects of transdermal nitroglycerin (NTG) in patients with heart failure (CHF), the short‐term hemodynamic responses to transdermal NTG, in a 20 cm2 self‐adhesive patch (10 mg/24 h), were evaluated in 10 patients with severe chronic CHF using a randomized, within‐patient, double‐blind, placebo‐controlled cross‐over trial. Serial hemodynamic measurements over 24 h revealed sustained effects that began 1 h after the application of nitroglycerin patch and fully persisted throughout the study. The peak effect occurred at 4 h with the pulmonary capillary wedge pressure decreasing from 33.7±8.4 to 21.4±9 mmHg (mean ± SD) (p>0.05) and the cardiac index increasing from 2.5±0.6 to 3±0.6 1/min/m2 (p>0.01). Transdermal nitroglycerin also significantly reduced pulmonary arterial and right atrial pressures (from 43.5±9.5 to 31 ±11.4 and from 7.4±6.6 to 3.8±4.7 at peak effect, respectively) as well as pulmonary and systemic vascular resistances (from 10.7±6.6 to 6.5±3.2 and from 26.2±5.1 to 22.5±5.7, respectively). There was no change in heart rate or systemic arterial pressure. These beneficial hemodynamic responses persisted for 24 h. No rebound deterioration occurred upon withdrawal of the nitroglycerin. No significant hemodynamic changes occurred during placebo treatment period. Thus, low doses (10 mg/24 h) of transdermal nitroglycerin induce significant hemodynamic benefit that is sustained for 24 h in patients with heart failure. The lack of attenuation of the effects with this dose suggests that larger doses may in fact promote the development of tolerance.
Complete absence of pulmonary veins
Authors: Ralston M. A. , Teske D. W. 
Published: February 2009

AbstractVarious types of pulmonary venous return abnormalities have been described in the literature. This report presents a case in which a 4‐h‐old neonate presented with cyanotic heart disease and respiratory distress. This neonate was subsequently shown to have complete absence of the pulmonary veins (CAPV), a previously undescribed malformation. The case summary describes the physical findings, radiographic and electrocardiographic features, cardiac catheterization data, and results from autopsy. A discussion of the case, theories of embryological etiology for this malformation, and differential diagnoses follow. Surgical treatment for CAPV is not yet possible.
Clinicopharmacological studies of a newly synthesized cardiotonic agent (TA‐064) in patients with congestive heart failure
Authors: Bito K. , Kinoshita M. , Ozaki N. , Sakoda S. , Tsutamoto T. , Motomura M. , Mitsunami K. , Fukuhara T. , Kawakita S. 
Published: February 2009

AbstractIn animal experiments, a new inotropic agent, (‐)‐(R)‐1 ‐(p‐hydroxphenyl)‐2‐[(3,4‐dimethoxyphenetyl)amino]ethanol, designated TA‐064 was found to possess a more positive inotropic than chronotropic action. Its effectiveness and lack of significant toxicity make it beneficial for clinical use as a cardiotonic in human heart failure. The effects of TA‐064 were investigated in patients with various types of heart disease (n=29). Cardiac output increased, left ventricular end‐systolic dimension decreased, and left ventricular fractional shortening increased for 15 minutes after a single intravenous dose (1 mg). The plasma level of TA‐064 at the cessation of infusion was 61.1 ± 49.6 ng/ml and thereafter declined biexponentially. After a single oral dose (10 mg), TA‐064 appeared in the plasma at 30 minutes and reached its peak levels of 13.7 ± 5.6 ng/ml at 60 minutes. Seven hours later, the plasma level was 5.9 ± 3.1 ng/ml which was considered to be within the effective range according to the results after intravenous administration. In conclusion, minimal effective plasma levels of TA‐064 are obtained by oral administration of 10 mg three times a day.
Familial case of permanent form of junctional reciprocating tachycardia: Possible role of the HLA system
Authors: Perticone F. , Marsico S. A. , Marsico S. A. 
Published: February 2009

AbstractThe permanent form of junctional reciprocating tachycardia (PJRT) is a very rare arrhythmia with the following clinical and electrocardiographic findings: (1) it occurs predominantly in infants and children; (2) it is almost incessant and refractory to pharmacological therapy; (3) the onset is commonly related to a critical shortening of the P‐P cycle length without P‐R prolongation; (4) during tachycardia the ECG shows an R‐P longer than P‐R interval, with a negative P wave in leads II, III, aVF. Recently, the anatomic and electrophysiological characteristics underlying PJRT have been identified: there is an accessory pathway of working myocardium with decremental properties, located in the posterior pyramidal space. A case of familial PJRT is reported: the arrhythmia has been documented in a 72‐year‐old female and in her 16‐year‐old grandson. Several triggering tachycardia mechanisms have been observed. Tachycardia was almost incessant and the heart rates were 115 and 135 beats/min, respectively. Typing according to the HLA system, performed in all members of the family, demonstrated the Bw41 antigen in both our patients as well as in the boy's paternal uncle. This is the first documented familial case of PJRT, but the possible significance and correlation with the Bw41 antigen should be further investigated.
Right bundle‐branch block in coronary artery disease: a hemodynamic and angiographic study
Authors: Dabizzi R. P. , Aiazzi L. , Barletta G. A. , Teodori G. 
Published: February 2009

AbstractThirty‐four patients with right bundle‐branch block (RBBB) and coronary artery disease (CAD) (RBBB was not pre‐existent to clinical development of CAD) and 52 consecutive CAD patients without conduction disturbances were studied and compared to verify whether the presence of RBBB implies more severe and extensive left ventricular myocardial damage as well as more severe CAD. The two groups did not differ either in age or in New York Heart Association functional class. The incidence or location of previous myocardial infarction (MI) was not different in the two groups. No significant differences were found in left ventricular volumes or ejection fraction. Higher end‐diastolic left ventricular pressure and more severe and diffuse left ventricular wall asynergy were present in RBBB patients. At coronary arteriography, more severe involvement of the right coronary artery in CAD patients without conduction disturbances was the only significant finding. The group of patients with CAD and RBBB without MI showed significantly less involvement of the left anterior descending coronary artery and significantly more severe damage of the inferior wall of the left ventricle than the group with CAD without RBBB and MI. Patients with inferior wall MI and RBBB had more severe asynergy of the posterobasal region of the left ventricle than did patients with inferior wall MI without RBBB. The group of patients with anterior wall MI and RBBB had a higher left ventricular end‐diastolic pressure, a lower left ventricular ejection fraction, and a greater extent of myocardial damage compared to similar patients of the control group. The groups with MI and RBBB had the same Gensini's score as similar groups without RBBB. The hemodynamic, angiographic, and ventriculographic findings in 14 of the 34 RBBB patients who had also presented an abnormal QRS frontal axis deviation showed no significant differences in comparison both with the CAD control group and the remaining RBBB patients with normal QRS frontal axis. These data support the hypothesis that conduction defects and diffuse left ventricular damage do not emanate from anatomical coronary lesions.
Association of coronary calcification with obstructive disease in coronary arteries in indian patients
Authors: Wasir H. S. , Dev V. , Kaul U. , Rajani M. , Mukherjee S. , Sharma S. , Bhatia M. L. 
Published: February 2009

AbstractA total of 1150 consecutive patients (1052 males and 98 females; age 51.2±10.1 years) with suspected coronary artery disease (Group I) were subjected to fluoroscopy for detection of coronary artery calcification (CAC) and coronary angiography. Another group (Group II) of 120 patients (95 males and 25 females; age 51.4±9.4 years) catheterized for cardiac diseases other than coronary artery disease (CAD) were subjected to the same protocol of fluoroscopy and coronary angiography to exclude incidental CAD in view of their age. CAC was present in 240 patients (20.0%) in Group I. Of these, 200 (83.4%) had triple‐vessel disease (TVD); 20 (8.3%) had double‐vessel disease (DVD); 19 (7.9%) had single‐vessel disease (SVD); and 37 (15.4%) patients had left main coronary disease (LMCAD). Only one of these patients had insignificant CAD considered as “normal” coronary arteries (NC). Incidence of LMCAD, TVD, DVD, SVD, and NC in patients without CAC was 4.4%, 56.3%, 18.2%, 14.0%, and 11.5%, respectively. Incidence of CAC in patients with LMCAD, TVD, DVD, SVD, and NC was 48.1%, 28.1%, 10.8%, 13.0%, and 1.0% respectively. In Group II (n = 120), 24 patients (20%) had CAD, CAC was present in 5 patients with CAD (20.9%), and in two patients without CAD (2%). CAC is relatively uncommon in Indian CAD patients. Its presence, however, indicates severe multivessel disease.
The old‐age heart: Normal aging changes which can produce or mimic cardiac disease
Authors: Waller B. F. 
Published: February 2009

AbstractThe elderly segment of our society may triple by the year 2050. Specific cardiovascular data on the normal aging heart will be needed to provide proper medical and surgical therapy for this patient group. This report reviews normal aging changes of the very elderly heart. Expected or normal aging changes include brown atrophy of the myocardium, increased subepicardial fat, focal amyloid deposits, sigmoid‐shaped ventricular septum, and calcific deposits in the aortic valve, mitral annulus and epicardial coronary arteries. Certain normal aging changes may produce clinical heart disease: aortic valve calcium (aortic stenosis), mitral valve annular calcium (mitral stenosis), amyloid deposits (amyloid heart disease). Certain normal aging changes may mimic heart disease: sigmoid‐shaped ventricular septum (hypertrophic cardiomyopathy), mitral leaflet “buckling” (floppy mitral valve).
Coronary collateral development after acute myocardial infarction
Authors: Fujita M. , Sasayama S. , Ejiri M. , Asanoi H. , Nakajima H. , Miwa K. 
Published: February 2009

AbstractIn 31 patients without a history of preinfarction angina, coronary collateral circulation to the completely obstructed coronary artery was evaluated by coronary angiography during a convalescent period of their first myocardial infarction. Collateral visualization (collateral index) was found to be significantly greater in patients with involvement of the right coronary artery (2.1 ± 1.1, SD) than in those with obstruction of the left anterior descending coronary artery (1.2±1.0, p<0.05). The time interval from the onset of symptoms of acute myocardial infarction to angiographic evaluation did not affect the extent of collateral visualization or the degree of coronary artery disease. These findings indicate that the collateral vessels develop after acute myocardial infarction regardless of the extent of coronary artery disease and accomplish the proliferative process within one month. It is also suggested that the collateral visualization is dependent on the size of perfusion territory of the infarct‐related coronary artery.
Heart rate and catecholamine contribution to qt interval shortening on exercise
Authors: Davey Patrick , Bateman Jeffrey 
Published: February 2009

AbstractBackground: QT interval shortens with exercise. Some of this shortening is due to an increase in heart rate, and some is due to other effects of exercise, probably mostly neuroendocrine effects. Data from subjects with cardiac transplants have suggested that non‐heart rate‐related changes in QT interval on exercise are due to the effects of circulating catecholamines.Hypothesis: We sought to determine whether changes in plasma catecholamine levels with exercise are an important contributor to non‐heart rate‐related QT interval shortening.Methods: Subjects with DDD pacemakers were recruited. Subjects had QT intervals measured at rest, during a low fixed level exercise test designed to increase heart rate to about 110 beats/min, and, after resting, during pacing at a heart rate of 110 beats/min. Catecholamine levels were measured at each stage of the study.Results: QT interval at rest was 420 ± 12 ms, during pacing 366 ± 16 ms, and on exercise 325 ± 14 ms. This then gave the proportion of QT interval shortening due to heart rate as 68.6 ± 9.3% of total QT shortening, with the range between 35 and 95.6%. There was no proportionality between the degree of QT interval shortening on exercise that was not due to increases in heart rate and changes in plasma catecholamine levels.Conclusion: Two‐thirds of exercise‐induced QT interval shortening are due to an increase in heart rate, and one‐third to other effects. Changes in plasma catecholamine levels on exercise were not closely related to changes in the QT interval on exercise.
Dasatinib treatment for Philadelphia chromosome‐positive leukemias
Authors: Khoury Hanna Jean , Guilhot François , Hughes Timothy P. , Kim Dong‐Wook , Cortes Jorge E. 
Published: February 2009

AbstractDasatinib is a highly potent Bcr‐Abl inhibitor that is approved for the treatment of imatinib‐resistant or ‐intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome‐positive acute lymphoblastic leukemia. Across a series of phase 2 and 3 trials, dasatinib was associated with durable treatment responses in all phases of the disease and was well tolerated. For this article, the authors reviewed available information on specific side effects associated with the use of dasatinib. On the basis of more than 2 years' experience of dasatinib treatment during clinical trials, they provide practical recommendations for side‐effect management. Cancer 2009. © 2009 American Cancer Society.
The impact of pregnancy on breast cancer outcomes in women ≤35 years
Authors: Beadle Beth M. , Woodward Wendy A. , Middleton Lavinia P. , Tereffe Welela , Strom Eric A. , Litton Jennifer K. , Meric‐Bernstam Funda , Theriault Richard L. , Buchholz Thomas A. , Perkins George H. 
Published: February 2009

AbstractBACKGROUND:Some evidence suggests that women with pregnancy‐associated breast cancers (PABC) have a worse outcome compared with historical controls. However, young age is a worse prognostic factor independently, and women with PABC tend to be young. The purpose of the current study was to compare locoregional recurrence (LRR), distant metastases (DM), and overall survival (OS) in young patients with PABC and non‐PABC.METHODS:Data for 668 breast cancers in 652 patients aged ≤35 years were retrospectively reviewed. One hundred four breast cancers (15.6%) were pregnancy‐associated; 51 cancers developed during pregnancy and 53 within 1 year after pregnancy.RESULTS:The median follow‐up for all living patients was 114 months. Patients who developed PABC had more advanced T classification, N classification, and stage group (all P < .04) compared with patients with non‐PABC. Patients with PABC had no statistically significant differences in 10‐year rates of LRR (23.4% vs 19.2%; P = .47), DM (45.1% vs 38.9%; P = .40), or OS (64.6% vs 64.8%; P = .60) compared with patients with non‐PABC. For those patients who developed breast cancer during pregnancy, any treatment intervention during pregnancy provided a trend toward improved OS compared with delaying evaluation and treatment until after delivery (78.7% vs 44.7%; P = .068).CONCLUSIONS:Young patients with PABC had no statistically significant differences in LRR, DM, or OS compared with those with non‐PABC; however, pregnancy contributed to a delay in breast cancer diagnosis, evaluation, and treatment. Primary care and reproductive physicians should be aggressive in the workup of breast symptoms in the pregnant population to expedite diagnosis and allow multidisciplinary treatment. Cancer 2009. © 2009 American Cancer Society.
Symbolic analysis of (MO)(I)CCI(II)(III)‐based analog circuits
Authors: Tlelo‐Cuautle E. , Sánchez‐López C. , Moro‐Frías D. 
Published: February 2009

AbstractNew nullor‐based models are introduced to describe the behavior of the first generation current conveyor (CCI), second generation current conveyor (CCII), third generation current conveyor (CCIII), their inverting equivalents (ICCI(II)(III)), and/or their multiple output topologies (MO(I)CCI(II)(III)). These nullor equivalents include only grounded resistors to improve the formulation of equations in symbolic nodal analysis. In this manner, it is highlighted the usefulness of the proposed models to calculate analytical expressions in MO(I)CCI(II)(III)‐based analog circuits. Copyright © 2009 John Wiley & Sons, Ltd.
Wavelength retuning without service interruption in an all‐optical survivable network
Authors: Hu Rose Qingyang , Hu Weiwei , Jin Mingzhou , Qian Yi 
Published: February 2009

AbstractThis paper proposes a new wavelength retuning (WRT) scheme in an all‐optical WDM network. Compared with the existing WRT schemes developed for all‐optical networks, which can alleviate the wavelength‐continuity constraint but cannot avoid service interruption or data loss, the proposed scheme is able to alleviate the wavelength‐continuity constraint and reduce the connection blocking probability with no service interruption to the on‐going traffic. This is achieved by allocating two routes, one for active path and one for backup path, to each incoming connection request and conducting WRT only on the backup path. The backup path provides an alternate path in case of a failure, while the active path carries traffic under normal conditions. Thus, WRT on the backup path will not cause any impact on data transmission. An optimal backup path WRT scheme and a heuristic algorithm are developed and the performance evaluation on the proposed schemes is presented. The simulation results show that the proposed optimal scheme reduces the connection blocking probability by 46.8% on average, while the proposed heuristic scheme reduces the blocking probability by 28.3% on average, all compared with the scheme without WRT. Copyright © 2009 John Wiley & Sons, Ltd.
Successful establishment of MEKC with electrochemiluminescence detection based on one functionalized ionic liquid
Authors: Xu Yuanhong , Fang Lanyun , Wang Erkang 
Published: February 2009

AbstractHerein, one water‐soluble functionalized ionic liquid, 1‐butyl‐3‐methylimidazolium dodecyl sulfate ([BMIm+][C12H25SO−4]), was designed and its superiorities either used as supporting electrolytes or as additives for successful establishment of MEKC with electrochemiluminescence (ECL) detection (MEKC‐ECL) method were investigated. Compared with the common supporting electrolytes such as phosphate solution, 1‐butyl‐3‐methylimidazolium dodecyl sulfate solution used as running buffers led to greatly enhanced ECL intensities and column efficiencies for negative targets, a little increase for neutral‐charge ones while maintained nearly unchanged for positive ones due to the electrostatic forces between the large cation BMIm+ and the solutes and the hydrophobic interactions resulting from the large anion C12H25SO−4. Moreover, resolution efficiency between analytes was significantly improved. As the existence of ionic liquid moiety, BMIm+, accelerated the electron transfer at the electrode surface, the poisoning effect of long chain C12H25SO−4 on the electrode surface was eliminated and reproducible ECL intensities with relative standard derivation of 1.02% (n=6) were obtained. The proposed novel MEKC‐ECL system was again validated by the baseline separated two similar amino acids of proline and hydroxyproline with lower detection limits of 0.5 and 0.8 μM (S/N=3), respectively.
Evaluation of gel electrophoresis conditions for the separation of metal‐tagged proteins with subsequent laser ablation ICP‐MS detection
Authors: Raab Andrea , Pioselli Barbara , Munro Caroline , Thomas‐Oates Jane , Feldmann Jörg 
Published: February 2009

AbstractAlthough laser ablation (LA)‐ICP‐MS has been reported for the determination of metalloproteins separated by gel electrophoretic techniques (GE), systematic studies that define the conditions essential for successful measurements are still scarce. In this paper we present the results of our studies of basic conditions for the effective application of GE‐LA‐ICP‐MS for the separation of metal‐binding proteins, focusing on their stability during GE and post‐separation gel treatment. The stability of metal–protein complexes (haemoglobin, myoglobin, superoxide dismutase, carbonic anhydrase, transferrin, albumin, cytochrome c) during GE is dependent on the nature of the metal–protein interaction and the principle of separation. We have observed that non‐denaturing GE is a suitable separation technique for most metal–protein complexes (e.g. Zn in carbonic anhydrase and Fe in Tf and myoglobin were quantitatively recovered in a spiked liver cytosol), whereas separation by denaturing GE strongly impaired the stability of the complexes. Equally important is the post‐separation treatment of the gel to enable successful detection of the metal. LA‐ICP‐MS requires drying of the gel without loss of protein‐bound metal or cracking of the gel. This was successfully achieved using glycerol followed by heating. We demonstrate that staining of the gel prior to LA‐ICP‐MS using silver or Coomassie blue is not recommended, since most protein‐bound metal is lost during the staining procedure. Furthermore it has been shown that only line scanning with a speed of less than 30 μm/s can reliably distinguish between lines 1 mm apart, while raster spot analysis carries the risk of misinterpretation due to contamination in/on inhomogeneous gels.
A PDMS sheath flow cuvette for high‐sensitivity LIF measurements in CE
Authors: Skinner Cameron D. 
Published: February 2009

AbstractA simple method for producing a sheath flow cuvette in PDMS suitable for post‐column detection in CE is described. Two types of cuvette were investigated. In the first, the sheath flow channel had a round cross‐section of approximately 635 μm diameter, whereas the second cuvette had a 300×300 μm2square channel. Both cuvettes produced laminar flows that ensheathed the separation capillary's effluent allowing sensitive fluorescence measurements. The elasticity of the PDMS allowed the 300×300 μm2square sheath flow channel to expand uniformly and accommodate the larger 330–340 μm od round separation capillary, producing a self‐aligning cuvette with robust mechanical properties. With this cuvette, linear calibrations of over five orders of magnitude and 15–30 zmol fluorescein detection limits were obtained for 12 and 50 μm id capillaries.
Attomole protein analysis by CIEF with LIF detection
Authors: Ramsay Lauren M. , Dickerson Jane A. , Dovichi Norman J. 
Published: February 2009

AbstractWe have coupled CIEF with an LIF detector that is based on a post‐column sheath flow cuvette. We employed Chromeo P503 as a fluorogenic reagent to label proteins before analysis. This reagent reacts with the ε‐amine of lysine residues, preserving the cationic nature of the residue; labeled proteins generate extremely sharp peaks in CIEF. A set of four standard proteins generated a linear relationship between migration time and pI. A protein homogenate prepared from a Barrett's esophagus cell line resolved over 100 components in a 40 min separation. Detection limits for Chromeo P503‐labeled β‐lactoglobulin were 5 amol injected into the capillary. Fluorescent impurities present in the ampholytes generated a large background signal that degraded the detection limit by four orders of magnitude compared with other forms of capillary electrophoresis with this detector.