bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF NOSOLOGIES AND MEDICINES USED BY THE APPLICANTS OF HIGHER MEDICAL EDUCATION AT PRE- AND POSTGRADUATE LEVELS (BY THE RESULTS OF SOCIOLOGICAL RESEARCH)
Authors: Zaremba N.I. , Zimenkovskyi A.B. 
Published: April 2024

Purpose of the study is the analysis of nosologies and medicines used in self-treatment by the applicants of higher medical education.
Materials and methods of research. The scientific work performed on the results of a sociological study involving 400 applicants of education at pre- and postgraduate levels at Danylo Halytsky Lviv National Medical University.
Results and discussion. The majority of surveyed (56,50±2,48 %) did not systematically take analgesics, mainly with headache. However, only 4,75±1,06 % questioned with feeling heaviness in the stomach always took enzymes. The vast majority of questioned (79,25± ±2,03 %) had never taken BAAs. It was found out that the respondents took medicines from the groups of non-narcotic analgesics, vitamins and antispasmodic remedies during the last month. The most frequent reasons why surveyed took medications regularly were infectious and gastrointestinal diseases. Extremely rarely questioned with diseases of the musculoskeletal system and the eye took drugs constantly. 29,75±2,29 % respondents had cases of combination of alcohol and drugs. The side effects and high costs of medicines were the most often noted among the factors causing warning of surveyed in pharmacotherapy. A three times lower specific weight of questioned indicated a lack of drugs in pharmacies; lack of knowledge of the mechanism of action and interaction with other medicines. In the overwhelming majority (75,50±2,15 %) medications influenced the quality of their lives by improving well-being and working capacity. However, every 7th respondent had side effects of medicines. In our opinion, the obtained results should serve as the basis for working out a comprehensive model of the program of prevention of negative consequences of self-treatment, first of all among young people.
Conclusions. In our opinion, the obtained results should serve as the basis for working out a comprehensive model of the program of prevention of negative consequences of selftreatment, first of all among young people.
THE ROLE OF AMINO ACID COMPOUNDS OF BLOOD PLASMA AND ITS INDICES IN THE DEVELOPMENT OF ARRHYTMIC COMPLICATIONS AND STRATTIFICATION OF CARDIOVASCULAR RISK IN PATIENTS WITH STABLE ISCHEAMIC HEART DISEASE ON THE BACKGROUND OF DIABETES MELLITUS TYPE 2
Authors: Belikova J. 
Published: April 2024

Objective: to improve the prediction of arrhythmic complications, the stratification of cardiovascular risk (СVR) and to develop a differentiated approach to the appointment of metabolic cardiopotectors (MC) based on the study of the amino acid composition of blood (ASC).
Object and methods of investigation The data of examination of 72 patients with stable ischemic heart disease (IHD) on the background of diabetes mellitus type 2 (DM 2) (38 men and 34 women, median ages -65,1 year) and 22 patients with stable coronary heart disease without violations of carbohydrate metabolism were analyzed. 20 amino acids (AMC) and the relationships between them were determined, in which AMCs were combined by a competitive mechanism of transport into the cell. According to the results of holter ECG monitoring, patients were divided into 2 groups: with and without arrhythmias of ischemic genesis (AIG) of high grades.
Results For patients with IHD, against the background of DM 2, AIG is characterized by a reduced content of taurine (Tau) (by 38.4%), an increase in alanine (Ala) (by 21.42%), a total content of aromatic amino acids (ARA) (by 32.97%) in comparison with patients with prognostically indifferent arrhythmias. The risk of AIG is associated with Tau / Ala indices (<0.048) and aromatic amino acids/ metionin (ARA / Met) (> 34.41), regardless of the availability of demographic, anamnestic and clinico-laboratory risk predictors.
Conclusion: Amino acid indices should be used as prognostic markers of AIG for the purpose of treatment of patients with IHD on the background of CD2. Tau and ARL are the most suitable for screening purposes, Тau / Ala (<0.048) and ARA / Met (> 34.41), it is more appropriate to use for the intended purpose of MC and as a control of treatment.
ДОСЛІДЖЕННЯ КОРИСТУВАЧІВ МОБІЛЬНИХ ПРИСТРОЇВ МЕТОДОМ АНКЕТУВАННЯ ТА ОБ’ЄКТИВНОЇ АУДІОМЕТРІЇ (ОТОАКУСТИЧНА ЕМІСІЯ)
Authors: Fedorchenko Daria , Didkovsky Vyacheslav 
Published: April 2024

Мета: Основною метою проведеного дослідження було визначити вплив користу- вання мобільними пристроями серед молоді в Україні на слуховий аналізатор методом анкету- вання та об’єктивної аудіометрії (отоакустична емісія) та порівняти отримані результати отриманих даних з даними отриманими в дослідженнях проведених в Швеції та Фінляндії, котрі були першими, хто провів багаточисельні дослідження стосовно погіршення слуху та виникнення інших симптомів при використанні мобільних пристроїв. Методи: Учасників дослідження було відібрано зі волонтерів, яким були розіслані анонімні анкети з питаннями. Кількість осіб, які за- повнили анкету склала 251. Була використана стратифікована вибірка за віком, статтю, яким телефоном користуються, скільки часу приділяють на розмови, розмовляють з навушниками чи без, та як розмови по телефону вплинули на здоров’я (головний біль, вушний шум, погіршення слуху). Результати: Згідно опитування середній вік респондентів склав 17-25 років (32,3% - 22 р., 13,1% - 19р., 12,4% - 20р., 10,8% - 23 р., 8,4% - 21р., 8% - 18р., 7,6% - 17р., 2,8% - 24р., 2,8% - 25р.).
Таким чином середній вік молодого і працездатного віку склав 22 роки. Кількість жінок склала 74,3%, чоловіків – 25,7%. Майже всі респонденти користуються мобільним телефоном (99,2%), тому подальші дослідження будуть пов’язані з цим видом зв’язку. 51,8% розмовляють за допомо- гою додаткових пристроїв (навушники), 8,8% - без додаткових пристроїв, 39,4% розмовляють за допомогою обох варіантів. Було досліджено вплив розмов по телефону на самопочуття та здоров’я після розмов. 3,6% студентів відчувають головний біль після розмов по телефону, 96,4% головний біль не відчувають. 58,2% відчувають головний біль протягом тижня, 41,8% головного болю не мають. Більшість респондентів пов’язують головний біль протягом тижня з втомою, недосипанням, стресом і нервовим напруженням під час навчання, зі зміною погоди, з порушеним режимом дня, артеріальною гіпертензією, голодом, з частими розмовами по телефону. 42,2% рес- пондентів відчувають вушний шум: 1,6% з них відчувають вушний шум кожний день, 4,8% раз в декілька днів, 35,9% зрідка. 57,8% взагалі шум не відчувають. 21,5% респондентів відчувають погіршення слуху, 78,5% респондентів погіршення слуху не відчувають. Респондентам, які ма- ють погіршення слуху, було запропоновано пройти дослідження об’єктивну аудіометрію (ото- акустична емісія) для дослідження змін слуху. Шістдесят респондентів взяло участь у цьому обстеженні Перед дослідженням було проведено отоскопію респондентів для виключення будь- яких органічних уражень вух. У 85 вух респондентів (71%), які скаржилися на погіршення слуху, на частоті 8000 Гц не було зареєстровано відповіді. У 95 вух респондентів (79%), які скаржилися на погіршення слуху, на частоті 5714 Гц не було зареєстровано відповіді. Коефіцієнт кореляції, який вираховувався за Пірсоном, між показникам респондентів Києва та результатів дослідження в країнах північної Європи склав 0,935, що вказує на значно високу силу зв’язку.
PREDICTING FRACTURE FRACTURE FAILURE BASED ON AN ANALYSIS OF RISK FACTORS DETERMINED BY PATIENT CHARACTERISTICS
Authors: Kylymniuk L.O. 
Published: April 2024

Relevance. Disorders of osteoreparation become a serious problem of modern traumatology and orthopedics. The high incidence of complications of reparative osteogenesis, period of treatment, incapacity for work causes significant economic costs and the urgency of further study.
Aim: to establish the values of risk factors determined by patient characteristics in predicting fracture healing complications.
Materials and Methods. The data of 67 patients with fracture healing complications of long tubular bones and 67 patients with analogous fractures without disorders of reparative regeneration, whowere treatedat the Department of traumatology in Vinnytsia Clinical Emergency Hospital, were analyzed. The average age was 49.67 ± 16.32 years. Delayed unionwas established in 25 (37.31%) patients, nonunion in 42 (62.69%). There was no significant difference in gender and age characteristics between patients of both groups. The probability of an error-free forecast was set at pd”0.05. The statistical processing of the data was carried out using the program Statistica 10.
Results. Among the lifestyle’s factors a direct relationship with the probability of fracture healing complications was established in the smokers of the study group (р=0.002). Among the comorbid conditions, the highest chances are found in patients with diabetes mellitus (р=0.02), peripheral vascular diseases (р=0.0003), systemic connective tissue diseases (р=0.01), anemia (р=0,004) and hypothyroidism (р=0.02). A significantly higher risk of fracture healing complicationswas found in patients who tooknonsteroidalantiinflammatory drugs from causes not related to trauma (p=0.000005). Acceptance of glucocorticosteroid drugs (p=0.006) and anticoagulants (p=0.009) was also associated with a higher risk of osteoreparation disorders.
Conclusion. As a result of the study, it was found that the presence of additional factors increases the risk of fracture healing complications.
АPLICATION OF AUTOPLASME ENRICHED BY THROMBOCYTES (PRP-THERAPY), IN THE TREATMENT OF PATIENTS WITH HEAVY DISEASE WITH THE ACCOUNT OF METABOLIC ACTIVITY OF PERIPHERAL BLOOD CELLS
Authors: Swyryd-Dzyadykevuch A. 
Published: April 2024

The effectiveness of combined treatment of patients with acne has been evaluated by determining its effect on the metabolic activity of peripheral blood cells and the clinical course of dermatosis. We observed 38 patients with a mild acute illness (22 women and 16 men aged 76 to 33 years). The duration of the pathological process varied from 7 months to 12 years. The content of glycogen was determined in neutrophils, monocytes and thrombocytes by means of a PAS-reaction. Results of evaluation using the average cytochemical coefficient (CCC). It has been established that in patients with acute disease there is a decrease in the glycogen content in neutrophils in the CCC = 2.05 ± 0.05 (in the control of SCS = 2.31 ± 0.08; p <0.05). This suggests changes in the energy potential of individual leukocyte subpopulations. In the platelets, the content of glycogen remained within the limits of physiological oscillations - CSC = 1.39 ± 0.08 (in the control of CCC = 1.43 ± 0.09; p <0.05), however, there was a redistribution of the number of cells with varying saturations of the metabolite. It is proved to increase the effectiveness of treatment of such patients by using as a adjuvant agent an autoplasma enriched with platelets.
Conclusions in acute illness there is a redistribution of energy possibilities of neutrophils and monocytes of peripheral blood. The content of glycogen in neutrophils and monocytes of peripheral blood in can serve as one of the criteria for the effectiveness of prescribed therapy. The use of an acute illness of an autoplasma enriched with platelets, increases the effectiveness of treatment due to its modulating effect on the metabolic activity of leukocytes and platelet peripheral blood.
THE LEVEL OF VITAMIN D3 IN PATIENTS WITH TYPE 2 DIABETES, DEPENDING ON THE PRESENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Udwan M.B. , Kobylak N.M. , Komisarenko Y.I. 
Published: April 2024

Introduction: Recently, vitamin D3 (cholecalciferol) deficiency has been considered as one of the factors for the development of type 2 diabetes mellitus (T2D) and metabolic syndrome (MS), which contributes to increased insulin resistance and reduced insulin secretion. The most pronounced vitamin D deficiency is observed in persons suffering from morbid obesity. The aim of this study was to assess the vitamin D3 status in patients with T2D, depending on the presence of non-alcoholic fatty liver disease (NAFLD).
Materials and methods: The study included 69 patients with T2D. NAFLD was diagnosed with ultrasound examination. All patients were divided by us into 2 groups. The control group consisted of 29 patients with T2D without NAFLD. The main group included patients with T2D and concomitant NAFLD (n = 39). Student’s t-test was used for independent samples. In the analysis of qualitative variables, the criterion ⵼ 2 was used. The significance level was considered significant at p <0.05.
Results: According to the obtained results, we observed significantly lower level of 25 (OH) D3 in patients with NAFLD compared with patients in the control group (28.25±12.67 vs. 19.9±8.67 ng/ml, p=0.002). Also, the presence of NAFLD in patients with T2DM associated with more pronounced metabolic disorders 25 (OH) D3. Vitamin 25 (OH) D3 deficiency in patients of the main group, which is determined, according to current recommendations, with a decrease in its level below 20ng/ml, was found in 73.5% of patients, which was significantly higher compared with the control group, where the deficiency was stated in 26.5% (p=0.014).
Conclusions: Our study demonstrated that patients with T2D and NAFLD showed significantly lower level of 25 (OH) D3 compared with patients in the control group.
FEATURES OF HEART LESION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (LITERATURE REVIEW)
Authors: Dubovyk V. , Kondratiuk V.E. 
Published: April 2024

An analysis of national and foreign scientific literature about the features of heart damage in systemic lupus erythematosus (SLE) is carried out. This topic is very relevant, because according to different authors, the frequency of cardiovascular system (CVS) damage in SLE ranges from 52 to 89%. Mortality because of SLE is three times higher than in the population, while among its causes, CVS ranks third after infections and renal failure.
The results of numerous studies about the features of the clinical picture, diagnosis and treatment of SLE patients with primary lesions of the heart are presented and analyzed. Particular attention is paid to lupus myocarditis (LM), endocarditis Libman–Sacks, as well as rhythm and conduction disturbances.
LM often makes its debut at early stage of SLE and in most cases is not clinically manifested. That is why LM is difficult to diagnose. LM can lead to arrhythmias, conduction disturbances, dilated cardiomyopathy (DCM), heart failure (HF) and even sudden death. The myocardium is involved in the pathological process according to autopsy in 40–80% of cases, but cardiovascular disorders are absent only in 7,5% of patients. Echocardiography (EchoCG), speckle-tracking EchoCG, MRI of the heart are necessary methods for the diagnosis of active or transferred LM. Early aggressive immunosuppressive therapy significantly improves the prognosis.
The detection rate of pericarditis in SLE is 25,6%. It was found in 62,1% of cases according to autopsy results. Pericarditis is usually combined with endocarditis or endomocarditis.
The morphological basis of heart defects that are formed in SLE is non–bacterial endocarditis of Libman–Sacks. The frequency of endocarditis is 73,3%. The course of endocarditis is predominantly benign and does not cause significant hemodynamic disturbances.
The frequency of rhythm disturbance remains quite high in all age groups of patients with SLE. It’s diagnosis is difficult due to the asymptomatic course and frequent joining of concomitant cardiovascular pathology.
ASSOCIATION OF GENOTYPES OF POLYMORPHISMS OF GENES FGFR2, LSP, AND LOC643714 WITH THE RISK OF A POSITIVE MUTATIONAL STATUS OF THE HER-2/NEU GENE IN BREAST CANCER PATIENTS
Authors: Klimuk Bogdana , Polinik Svitlana , Ribchenko Lyudmila , Zakhartseva Lubov , Dugan Oleksyi , Klymenko Sergiy 
Published: April 2024

Breast cancer is the result of genetic and environmental factors that lead to the accumulation of mutations in key regulatory genes. Genetic predisposition to cancer pathologies may be due to mutations in individual genes, such as in BRCA1 and BRCA2, or may be due to a cumulative effect as a result of the interaction of genes of low penetrance. This paper reviews the alleles that determine the risk of high and low penetrance breast cancer and discusses ongoing efforts to identify additional susceptibility genes. The identification of propensity genes is a prerequisite for an individualized assessment of breast cancer risk and a decrease in the incidence of breast cancer. The main goal of this study is to determine the associations of polymorphic variants rs2981582 and rs1219648 of FGFR2, rs3817198 of LSP and rs3803662 of LOC643714 with the risk of breast cancer and the development of a positive mutational status of Her-2/neu. The study group included 300 women diagnosed with breast cancer. Fluorescent in situ hybridization was performed on tumor tissue materials from these patients to determine the amplification status of the Her-2/neu. The distribution of genotypes and alleles was performed by real-time polymerase chain reaction for the following polymorphic variants rs1219648 of FGFR2 (n = 44), rs2981582 of FGFR (n = 99), rs3817198 of LSP1 (n = 75) and rs3803662 of the LOC643714 (n = 82). Among the studied genotypes of polymorphic variants rs3817198 of LSP1, rs3803662 of LOC643714, rs2981582 and rs1219648 of FGFR2, with the inclusion of the risk allele, the association of the propensity to develop breast cancer in women according to the multiplicative model of inheritance (p> 0.05) was not determined. According to the codominant inheritance model, there is an associative relationship with the risk of breast cancer and polymorphism rs3817198 of LSP1, rs3803662 of LOC64371 and rs2981582 of FGFR2 with homozygous genotypes for rare alleles (p <0.05). Women with a positive amplification status of the Her-2/neu, patients with breast cancer, were more likely to carry the risk allele G (OR = 4.80; 95% CI 1.21–28.04, p <0.05) and genotype GG ( OR = 5.82; 95% CI 1.38-16.74, p <0.05) rs3803662 polymorphism of LOC643714, compared with a group of women with negative amplification status of Her-2/neu in patients diagnosed with breast cancer. The results of this study can be useful for searching for additional genetic predictors of breast cancer and a positive mutational status of Her-2/neu.
ANALYSES OF CONCOMITANT BONE FRACTURES IN MILITARY PERSONNELWITHLIMBAMPUTATIONS IN THE AREA OF THE ANTITERRORIST OPERATION INEAST UKRAINE
Authors: Buryanov A.A. , Bespalenko A.A. , Tsema Ie.V. , Dinets A.V. 
Published: April 2024

The aim – to investigate and evaluate bone fractures in military personnel with limb amputations due to participation in the anti-terrorist operation (ATO) in the East Ukraine.
Patients and methods. All military personnel of the Armed Forces was included into study. Patients were identified with limb amputations in the period from 01.06.2014 to 30.06.2016 in the ATO zone, and were treated in medical institutions of the Ministry of Defense of Ukraine. Among 7091 patients with injuries in ATO, 152 patients with limb amputations were identified. Results and discussion. Out of 152 patients, 47 (31%) patients with limb amputations were also diagnosed with bone fractures, whereas in 107 (69%) patients amputations were not associated with bone fractures. The military rank of the cohort did not demonstrate significant difference. Ana- lyses of the level of amputation of the lower limbs showed femoral middle 1/3 in the group of patients with amputations and bone fractures in 6 (17%) patients, which is significantly more frequentas compared to the group of patients with amputations without concomitant fractures of bones – 3 (4 %) of patients (p = 0.023). Amputation of the foot in a group of patients with amputations and bone fractures was diagnosed in 2 (6%) patients, which is 4.5 times less often, as compared to 20 (27%) patients in the group of patients with amputations without concomitant bone fractures (p = 0.023). Linear regression showed a significant association of bone fractures and amputations of the foot (p = 0.012); which indicated the severity of the combined trauma in the cohort. Multiple logistic regression showed aOR 0.171 (95% CI 0.04-0.8), indicating a significant low probability of bone fractures during foot amputation (p = 0.022).
Conclusions. The results of this study of wounded patients in a hybrid war indicated that bone fractures are more often associated with amputations at the level of the femoral middle 1/3, but are less often diagnosed in patients with foot amputations. Bone fractures are not associated with the frequency of reamputation. Patients injured in the ATO zone in the East Ukraine demonstrated different clinical features as compared to other armed conflicts, and associated with amputations and other severe injuries.
CLINICAL AND LABORATORY ASSESSMENT OF GASTROINTESTINAL FUNCTION IN CHILDREN WITH ACUTE NEUROINFECTION
Authors: Markov A.I. 
Published: April 2024

Background. In cases of severe forms of infectious diseases, in addition to local inflammation, secondary lesions of the organs of the gastrointestinal tract may occur. We aimed to study the semiotics and epidemiology of gastrointestinal symptoms in children with acute neuroinfection.
Material and methods. The study is observational, retrospective, type “case-control”. We analyzed cases of inpatient treatment of children aged 1 month to 18 years old with acute neuroinfections (meningitis, encephalitis and encephalomyelopolyneuropathy).
Results and discussion. The study included 117 children with acute central nervous system infectious. Clinical symptoms of GI tract infection were observed in 83 (70.9%) children. Among revealed symptoms disorders of intestinal motility like constipation and diarrhea were prevalent. Manifestations of hepatobiliary system dysfunction included increased transaminase level (ALT, LF, GGTP) and/or ultrasound changes (enlargement, diffuse structural changes) and were observed in 39.1% of patients. Among the laboratory parameters, elevated ALT level was observed in 8.3% of patients, bilirubin was elevated in only one child, alkaline phosphatase was above the age norm of 11.8%, an increased GGTP above the age norm was observed in 31.3% of patients. The I-FABP biomarker level was elevated in 86.4% of patients, and L-FABP was elevated in all (100%) patients. Clinical manifestations of gastrointestinal dysfunc- tion (the presence of at least one of the gastrointestinal symptoms) had an inverse relationship with the child’s age (rpb = -0.19, p = 0.033), correlated with staying in ICU (OR = + 5.25 CI: 1.62 -16,97), artificial ventilation (OR = =+ 4,5 DI: 1,00-21,69) and level of I-FABP (rpb = 0,34, p = 0,019).
Conclusions. Among gastrointestinal symptoms in children with acute neuroinfections, disorders of intestinal motility like constipation and diarrhea are most common. Hepatobiliary system dysfunction is mainly manifested by moderate changes in laboratory parameters. Biomarkers I- FABP and L-FABP are highly sensitive tests for the damage of the gastrointestinal tract and hepatobiliary system.