bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping Patterns and Psychosocial Distress in Hemophilia Patients: A Cross-sectional Study from South Gujarat, India
Authors: Bardolia Dhruv Devendra , Mehta Ritambhara Yeshwant , Dave Kamlesh Rushikray , Nemlekar Saumitra S. 
Published: March 2024

Abstract

Introduction:
Hemophilia is hereditary genetic disorder with defects in normal blood clotting mechanisms. It is characterized by a chronic course requiring lifelong treatment. Persons with hemophilia (PWH) are known to have significant stress due to socio-occupational impairments caused due to the illness. It affects the treatment outcomes adversely. There are few studies from India that have looked at the factors and prevalence of psychiatric comorbidities in this population.

Aim:
To study coping patterns, perceived stress, anxiety, and depression profiles in adult patients of hemophilia.

Materials and Methods:
A purposive sample of 52 PWH was collected. We used a semi-structured questionnaire to obtain demographic data, illness profiles, and experience of complications and concerns of the participants. Scales used were Beck’s depression inventory, Anxiety scale, Holmes and Rahe Social Readjustment Rating Scale scale, and COPE questionnaire.

Results:
About 41% of the individuals had depression and 26.92% of individuals had trait anxiety. The state-dependent anxiety was seen in 69%. About 50% were found to be susceptible to stress-related illness. The adaptive coping style, namely, problem-focused coping, was associated with lower scores on the screening instruments. The presence of certain complications was associated with higher use of maladaptive coping strategies like the use of emotion and avoidance-focused coping.

Conclusions:
Considering the impact and morbidity, screening for psychological distress and analysis of coping styles of PWH should be a part of routine care.
Are We Missing Early-onset Frontotemporal Dementia as Late-onset Primary Psychiatric Disorder? A Case Series
Authors: Kulkarni Ranganath R. , Pai R. Shantheri , Pandurangi Swapna A , Kalachari Manjunath B. 
Published: March 2024

Abstract
Frontotemporal dementia (FTD) presents with a wide variability in clinical progressive syndromes, genetic etiologies, and underlying pathologies. Early diagnosis of combined features of behavioral and language variants of FTD poses a clinical challenge due to its complex heterogeneous clinical presentations, phenotypical overlap, and frequent normal neuroimaging during the initial phase. This masquerading nature has often led to unintended “misdiagnoses,” as typical dementia features evolve late. The enigmatic resemblance of early-onset (<65 years of age) FTD with a range of late-onset (>45 years of age) primary psychiatric disorders emphasizes the need for high index of clinical suspicion, thorough family history for neurocognitive disorders, and regular follow-up of such individuals. We describe the clinical profile and management of four cases of combined variant FTD (cvFTD) that clinically mimicked late-onset psychiatric disorders such as catatonia, depressive disorder, psychosis, and personality changes. Parkinsonian-like features and mid-brain atrophy in FTD may indicate phenotypical overlap and shared neuropathology with progressive supranuclear palsy.
Acceptance and Commitment Therapy in Managing Interference of Hallucinations
Authors: Kashyap Archana , Gupta Aarzoo , Sidana Ajeet 
Published: March 2024

Abstract
Schizophrenia is a disorder of thought and perception characterized by positive, negative, and cognitive symptoms; delusions, hallucinations, and negative symptoms are identified as the most common causes of suffering in schizophrenia. Multiple treatment approaches have aimed to deal with symptoms and disabilities caused by schizophrenia. Acceptance and commitment therapy (ACT) illuminates focusing on valued living without centering on symptoms, and alternately, it changes how an individual relates to his thoughts or feelings through awareness and increased psychological flexibility resulting in treatment outcomes. A 29-year-old graduate male have known schizophrenia since 2011, manifested decreased sleep, suspiciousness, the delusion of reference, thought broadcasting, and second, and third-person auditory hallucinations. A total of 30 sessions were taken in a span of 30–34 months that reduced the impact of hallucinations and resulted in significant improvement in personal and socio occupational functioning. His emotional insight helps him to set his goals and develop a plan to work toward them. ACT dissemination, in this case report, described how maximized attention on valued living elbowed the symptoms, reducing its role in day-to-day information processing and responding to the stimulus.
The Role of Attorney’s Request as a Communication Instrument in Advocacy
Authors: Inshyn Mykola , Shchokin Rostyslav , Semenets-Orlova Inna , Kravchenko Olha , Barsuk Maryna 
Published: March 2024

Abstract

Background:
The analysis of communication tools used in advocacy is currently a topical research problem in the context of dynamic information communication in the sociopolitical space.

Aims and Objectives:
The aim of the study was to analyze the attorney’s request as a means of obtaining information by attorneys to carry out their professional activity.

Materials and Methods:
The research was conducted with the help of numerous methods, the method of expert interviews being the leading one. It was used to single out the procedural characteristics and prospects of the attorney’s request in presentday Ukraine.

Results:
Attention is drawn to a number of issues that complicate the process of submitting attorney’s request and a proper use of this mechanism and procedure by an attorney. The ratification of the EU-Ukraine Association Agreement opens up new prospects not only for Ukrainian and European producers but also provides for interesting objectives for attorneys to consult the private sector in the process of building new markets.

Conclusion:
In this article, it was suggested to compare and analyze the issue of the attorney’s request in Ukrainian and Polish legal framework. As a result of the research, problems were identified, and proposals were made for a simplified procedure for submitting an attorney’s request as a communication instrument in advocacy.
Determining the Checkpoint of Transition from Thin to Thick Periodontal Phenotypes in the Maxillary and Mandibular Anterior Regions of South Indian Population
Authors: Pasupuleti Mohan Kumar , Chowdary G Rasagna , Penmetsa Gautami S. , Bypalli Vivek , Konathala Ramesh S. V. , Gottumukkala Sruthima N. V. S. 
Published: March 2024

Abstract

Aim:
The aim of this study was to compare and investigate the tissue thickness at the maxillary and mandibular central incisors utilizing the probe visibility method and traditional way of measuring gingival thickness (GT) by endodontic files.

Methodology:
In 200 selected patients, the GT was measured at both the maxillary and mandibular anterior using an endodontic file after local infiltration at the mid-distance from the gingival margin to the mucogingival junction. The checkpoint of transition from thin to thick periodontal phenotype was determined by probe visibility method in the following age groups: Group A: 21–30 years; Group B: 31–40 years; Group C: 41–50 years; and Group D: 51–60 years.

Results:
GT varied from 0.3 to 1.9 mm. Gingival translucency was observed up to the thickness of 0.7 mm. At 0.8 mm of GT, there was no probe visibility.

Conclusion:
According to the present research, the gingiva appears transparent up to a thickness of around 0.7 mm. The checkpoint of transition between thin and thick periodontal phenotypes at both the maxillary and mandibular anterior was associated with a GT of 0.8 mm.
Retained guidewire following the use of the straight end of Seldinger guidewire for hemodialysis catheterization
Authors: Ghatak Tanmoy , Kumar Neeraj , Singh Ratender K 
Published: March 2024

Abstract
Renal replacement therapy for kidney diseases usually requires hemodialysis catheterization. In literature, loss of a guidewire into the circulation is reported and this complication is preventable if appropriate measures are being used. This case report is of a 21-year-old female, who presented with intermittent fever and had dengue shock syndrome and acute kidney injury. A failed attempt to introduce a hemodialysis catheter of the right internal jugular vein was reported at some other hospitals. Using ultrasonography, X-rays, and computed tomography angiography of the neck, unraveling and guidewire loss were revealed. An unraveled Seldinger guidewire was removed after neck exploration. Migration of the guide in the central vein was revealed after puncturing the vascular wall. After surgical retrieval, the location of the retained guidewire revealed that the straight end of the Seldinger guidewire might have been used during catheterization. Proper training, skill-based learning, and early recognition of the signs of retained Seldinger guidewire are of utmost priority.
A population proportion to each stratum study on knowledge, attitude and practices on vaccine preventable hospital acquired infections
Authors: Ellenkil Anitta Jose , Bharadwajj Nitin Dutt , Mishra Uday Bhaskar 
Published: March 2024

Abstract

Background and Objective:
Health-care workers (HCWs) need to be immunized against vaccine-preventable diseases such as hepatitis B virus and tetanus. The study was conducted to assess knowledge, attitude, and practices on immunization against vaccine-preventable hospital-acquired infection (HAI).

Materials and Methods:
It was a cross-sectional descriptive study conducted in the clinical care areas of a tertiary care government teaching hospital. The study was conducted from June 2019 to June 2020. Institutional Ethics Committee approval was attained before taking up the study. A study sample of 407 was calculated by applying the population proportion to size formula to each stratum and was drawn among the resident (academic) doctors, staff nurses, and paramedical and housekeeping staff of the institute. The results were analyzed statistically.

Results:
Out of 407 study participants, 91 (22.4%) were resident (academic) doctors, 122 (30%) were staff nurses, 23 (5.7%) were paramedical staff, and 171 (42%) were housekeeping staff, respectively. The overall mean score for all the study participants’ knowledge, attitude, and practice for immunization against vaccine-preventable HAIs and health checkup among HCWs was 1.71 out of 2, 0.96 out of 1, and 1.18 out of 2, respectively.

Conclusion:
The knowledge with respect to immunization against vaccine-preventable HAIs and health checkup for HCWs was good for resident (academic) doctors. However, with respect to attitude and practice, it was found that the housekeeping staff and the staff nurses had better scores than the resident (academic) doctors. The author has suggested a few administrative measures in the article.
Huge lipoblastoma engulfing Hunter’s canal in a 3-year-old male child
Authors: Thakur Vinit Kumar , Runu Ritesh , Srivastava Saurav 
Published: March 2024

Abstract
Lipoblastoma in children is not an unheard entity. It is normally a benign mass seen in extremities and rarely involves deeper structures. Its complete excision is warranted to alleviate the symptoms and avoid future recurrence. We report an unusual case of huge lipoblastoma engulfing Hunter’s canal in a 3 years’ male child.
Anterior chamber parameters in simple myopia and hypermetropia using Pentacam
Authors: Anwar Fatma K.H. , Saleh Nashwa M.L. , Mohammed Ssnaa A. 
Published: March 2024

Background
Measurement of the anterior chamber parameters of the eye is an essential test and must be done in ophthalmic practice. Many studies were focused on the differences between the values of anterior segment parameters of myopic and hypermetropic eyes from that of emmetropic eyes. A significant correlation has been found between the RE and anterior chamber parameters. However, the strength of the correlation varied according to the race and the age of individuals.

Objective
To measure anterior chamber parameters (central corneal thickness, thinnest corneal thickness, apex corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and anterior chamber angle) in simple myopia and hypermetropia and emmetropia to evaluate their effect on the anterior chamber.

Patients and methods
Patients presented with errors of refraction. Their SE ranged between −5 and +5.37 D. Their mean age was 29.70±5.55 years, ranging from 20 to 39 years old. The study included 63 (52.5%) right eyes and 57 (47.5%) left eyes. We examined 120 eyes divided into three groups according to their SE. Group I (control group) included 40 eyes with normal refraction, group II included 40 eyes with simple myopia less than −6 D, and group III included 40 eyes with hypermetropia less than 6 D.

Results
The main central corneal thickness in emmetrope, myope, and hypermetrope was 518.45±50.99, 531.95±43.04, and 552.90±34.44 μm, respectively; corneal volume was 58.10±4.35, 60.17±3.94, and 61.03m3±3.99 m3, respectively; mean anterior chamber depth was 2.98±0.29, 3.34±0.29, and 2.63 ±0.28 m2, respectively; mean anterior chamber volume was 178.98±30.63, 202.25±28.50, and 133.68±25.76 m3m3, respectively; and mean anterior chamber angle was 37.61±6.00, 42.87±3.62, and 31.10±3.76°, respectively. Our results add to the evidence that errors of refraction have an effect on anterior chamber parameters.

Conclusion
This study provided valuable measurements of anterior chamber parameters of the Egyptian adults with error of refraction.
The role of MRI in the assessment of different causes of epilepsy
Authors: Moussa Dalia M. El Saeid Mohamed , Maghraby Hala M. , Hassan Rawhia T. 
Published: March 2024

Background and aim
Seizures are one of the most common medical problems affecting children, and epilepsy is the most common chronic neurological condition in children. The aim of this study was to highlight the different causes of epilepsy and to demonstrate and emphasize the usefulness of MRI epilepsy protocol on high-field magnet 3 T as imaging modality in the evaluation of pediatric epilepsy and its value in detecting subtle abnormalities that were commonly missed by previous nondedicated studies.

Patients and methods
This prospective study was conducted upon 40 pediatric patients diagnosed with epilepsy referred to a private center for MRI evaluation done on high-field magnet 3 T MRI, including the following sequences: three-dimensional T1 coronal (1 mm thick partition) with multi-planar reformat (MPR) on axial and sagittal, three-dimensional sagittal fluid attenuated inversion recovery (FLAIR) (1 or 1.5 mm thick, partition) with MPR on coronal and axial planes, high-resolution two-dimensional coronal T2‐weighted MRI, two-dimensional axial T2 (3 mm thickness), susceptibility weighted image (SWI) sequences (1.5 mm thick partition), and diffusion weighted image (DWI), as well as optional sequences, such as T1 MRI with gadolinium to look for contrast enhancement in the time interval between April 2018 and May 2020.

Results
The most common cause of epilepsy in our patients was malformation of the cortical development, accounting for 35% (14 patients), followed by neurocutaneous disorder and mesial temporal lobe lesions, each accounting for 25% (10 patients), followed by miscellaneous causes including brain tumors and vascular malformation [arterio-venous fistula (AVF), developmental venous anomaly (DVA), and cavernoma], accounting for 15% (six patients).

Conclusion
The dedicated MRI epilepsy protocol is a valuable tool in detection and illustration of the MR spectrum of different structural lesions causing pediatric seizures, describing the main MRI features of these disorders.
Assessment of portal hypertensive enteropathy in patients with liver cirrhosis
Authors: Afifi Mohammed A. , Hamid Gamal A. , Mousa Waleed M. , Ghareb Mohamed 
Published: March 2024

Background
Portal hypertensive enteropathy remains difficult to diagnose in patients with cirrhosis and portal hypertension (PHT). Limited test choices exist for the inspection of the small bowel in these patients. Small-bowel endoscopy like double-balloon enteroscopy (DBE) is ideal in this situation but rarely performed. We aimed to determine the prevalence of portal hypertensive enteropathy using DBE in the patient population with PHT and correlate its presence with clinical, radiological, and histological findings.

Patients and methods
Thirty-two patients with PHT were included along with 10 controls without the criteria of PHT. All patients and control groups underwent blood tests, ultrasonography, gastroscopy, and enteroscopy. The small-bowel findings by DBE were categorized as inflammatory-like and vascular lesions. The small-bowel changes either endoscopically or histologically were analyzed to find out any association with various demographic, clinical, ultrasonographic, and endoscopic variables.

Results
The frequency of portal enteropathy in our study was 65.6% (21 patients out of 32) and it had positive correlation with the presence of esophageal varices, PHG, and Child-Pugh score. We found that there is statistically significant difference between the results of histology among patients and control groups not only in the jejunal specimen but also in the gastric and duodenal ones. The correlation with the endoscopic picture was statistically not significant.

Conclusion
Small-bowel mucosal and vascular changes related to PHT were seen in a significantly higher number of patients with cirrhosis and PHT.
Synovitis evaluation in Egyptian patients with early rheumatoid arthritis
Authors: Abdelrahman Ghada H. , Abdelkader Mona A. , Mousa Sabila G. , Mohamed Nagwa A. , Abdelsalam Eman M. 
Published: March 2024

Background
Evaluation of synovitis in early rheumatoid arthritis (RA) is a crucial subject for appropriate management. Ultrasound (US) with high-resolution study has been confirmed a helpful aid in synovitis evaluation. Chemokine CXC ligand 13 protein (CXCL13), a potent B-cell chemoattractant, is expected to play a valuable role in pathobiology of RA.

Aim
To evaluate synovitis in early RA using serum CXCL13, US with high resolution, and power Doppler ultrasonography (PDUS), and their correlation with disease activity.

Patients and methods
A total of 40 patients with early RA fulfilling 2010 EULAR/ACR criteria of RA were assessed using disease activity score 28 for disease activity in RA, serum CXCL13, and US with high resolution. Moreover, 20 healthy age-matched and sex-matched patients were included as a control group.

Results
Serum CXCL13 levels were highly significantly increased in patients with early RA than controls (P<0.001). Regarding US with high resolution, patients with early RA had a significant increase in thickness of synovium and PDUS score compared with controls (P<0.001). In patients with early RA, serum CXCL13 significantly correlated with erythrocyte sedimentation rate, C-reactive protein, anti-cyclic citrullinated peptide, disease activity score 28, synovial thickness, and PDUS score. Moreover, there was a significant increase in serum CXCL13, synovial thickness, and PDUS score in patients with active RA when compared with patients with remitting RA (P<0.001).

Conclusion
Serum CXCL13 appears to be a new marker of synovitis in patients with early RA and correlates with thickening of synovium and PDUS scores that might reflect disease activity.
Vascular endothelial growth factor and its relation to ultrasonographic findings in juvenile idiopathic arthritis
Authors: Rageh Eman A. , Fahmy Fahmy E. , Alhamshary Azza A. , Mahmoud Sobhia A. , Hassan Asmaa S. 
Published: March 2024

Introduction
Vascular endothelial growth factor (VEGF) is a potent proangiogenic factor that acts selectively on endothelial cells, promoting angiogenesis. Angiogenesis plays a critical role in the pathogenesis of inflammatory arthritis, including juvenile idiopathic arthritis (JIA). Power Doppler ultrasonography is a noninvasive valuable technique that provides a reliable image of synovial angiogenesis that helps in evaluation of disease activity.

Aim
To evaluate serum VEGF in patients with JIA and correlate it with disease activity and ultrasonographic (US) findings and power Doppler of arthritic joints.

Patients and methods
A total of 50 patients with JIA were subjected to full history taking, clinical examination, routine laboratory investigations, measuring serum VEGF level, and musculoskeletal US examination. Moreover, 25 apparently healthy children were enrolled as controls.

Results
There was no statistically significant difference regarding serum VEGF between patient and control groups. No statistically significant correlation was found between VEGF and disease activity or US findings in patients with JIA.

Conclusion
The possible role of VEGF in disease activity of JIA remains unclear and needs further research.
Study of plasma methylglyoxal level in patients with type II diabetes mellitus
Authors: El-Hakeem Aml G.A. , Kotb Hend G. , Ahmed Amal M. , Youness Eman R. 
Published: March 2024

Background
Type II diabetes is a major risk factor for cardiovascular complications. Methylglyoxal (MGO) is the most hazardous glycating agent.

Objective
To assess the role of MGO in diabetic patients with cardiovascular diseases (CVD).

Patients and methods
This is a prospective study that was conducted on 60 patients with type II diabetes mellitus, comprising 30 males and 30 females, with age ranged from 50 to 62 years. They were classified into two groups: group 1 included 30 patients with type II diabetes mellitus with CVD based on patients known to have ischemic heart disease, hypertension, pervious history of angina pectoris, or myocardial infraction, along with positive findings in ECG and echocardiography. It included 15 males and 15 females. Their age was between 51 and 62 years, with mean±SD of 55.9±5.5 years. Group 2 included 30 patients with type II diabetes mellitus without CVD, based on not being hypertensive, having no history of chest pain, along with normal ECG and echocardiography. It included 15 males and 15 females. Their age was between 50 and 61 years, with mean±SD of 55.5±5.2 years.

Results
There were highly significant increases in MGO in patients with type II diabetes mellitus with CVDs compared with patients with type II diabetes mellitus without CVDs, with P value less than 0.001. There was a positive correlation between MGO and indices of glycemic control (fasting blood sugar, 2 h postprandial, and glycated hemoglobin). There was a positive correlation between MGO and cholesterol, triglycerides, low-density lipoprotein, BMI, diastolic dysfunction of the heart, and diabetic retinopathy, but there was a negative correlation between MGO and high-density lipoprotein and ejection fraction of the heart, which means that MGO level is increased in heart failure.

Conclusion
Our study proved the importance of MGO in type II diabetic CVD in humans. We need future studies to assess the role of MGO in diabetic complications.