bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Landscape Design in Enhancing Environmental Sustainability and Human Well-being
Authors: Tongyun Wang , Wei Zhou , Fei Xu 
Published: April 2024

Abstract
This study employs qualitative research methods to examine the impact of landscape design on promoting environmental sustainability and improving human well-being. The researchers conducted face-to-face interviews with a total of six students and three teachers. Using purposive sampling, the study seeks to identify current issues and suggest remedies pertaining to landscape design. The investigation is guided by three objectives, and nine sub-questions have been formulated to ensure a thorough and comprehensive analysis. The study employs NVivo 14 software for data analysis, utilising coding techniques to identify prominent themes. The research seeks to explore the difficulties, suggest remedies, and contribute to the development of sustainable and harmonious environments, as seen from the viewpoints of both students and teachers. The main goals are to identify current issues related to landscape design, investigate possible solutions, and analyse emerging patterns from interviews. The study aims to clarify the importance of landscape design in establishing sustainable ecosystems and enhancing human well-being by analysing both the obstacles and the remedies. This study enhances our comprehension of the intricate characteristics of landscape design and its consequences for both ecological sustainability and the interaction between humans and the environment.
Time Series Mapping and Monitoring of Agroforestry Area in Yamunanagar District of Haryana State Using Geospatial
Authors: Babu Bojja Harish , Arya Sandeep , Kumar K. E. Mothi , Nanda Krishma 
Published: April 2024

Abstract

Diverse agroforestry practices are prevalent in different Agro-Climatic regions of India and occupies substantial area. In Northern India’s Indo-Gangetic plains, agroforestry activities with respect to (eucalyptus) Eucalyptus tereticornis and (poplar) Populus deltoides based practices are very dominant. These agroforestry systems not only satisfy the need for wood to Wood-based Industries, but also contribute significantly to employment generation and the reduction of atmospheric Carbon dioxide (CO2) vis-à-vis mitigating climate change. Mapping and monitoring agroforestry areas by using the LISS-III and LISS-IV Multispectral High Resolution Satellite Remote Sensing data in the Yamunanagar district of Haryana has been undertaken to develop an operational method in the present research. Supervised classification method was used for land use land cover analysis for the year 2010 and 2019 in which training sites for seven parameters viz, agroforestry (Poplar, Eucalyptus based), agriculture, plantations (Horticulture, Scrub plantations, miscellaneous plantations) water bodies, forest, buildups, riverbed areas were mapped and monitored. The maximum area was estimated under agroforestry systems i.e. 4.06 and 9.69 percent, which includes both poplar and eucalyptus based Agri-silviculture and boundary systems for the year 2010 and 2019 respectively. Agricultural land, forests and other plantations constitute about 73.56%, 11.08% and 1.96% in 2010 and 67.77%, 10.99%, 1.7% in the year 2019 respectively of total district area. The accuracy of the image classification was delineated based on the ground truth data collected from the Yamunanagar district by using GPS (Global Positioning System) and accuracy found in Agroforestry was 90%.
Casual relationship between 731 immunophenotypes and sepsis: A Bidirectional Two-sample mendelian randomization study
Authors: Jiang Daishan , Bian Tingting , Shen Yan , Yuan Xiaoyu , Yang Yang , Shen Yanbo , Huang Zhongwei 
Published: April 2024

Abstract

Background
The causal relationship between immune cell phenotypes and their interactions with sepsis remains partially understood, with several aspects subject to debate. Our objective was to bidirectionally investigate specific immune cell phenotypes and their association with sepsis.
Methods
We performed bidirectional Mendelian randomization (MR) analysis using publicly available genome-wide association study (GWAS) summary statistics to investigate the causal links between 731 immunophenotypes and sepsis. We conducted comprehensive sensitivity analyses to ensure robustness and consistency and assess for possible horizontal pleiotropy of our results.
Results
The analysis, adjusted for multiple comparisons using the Bonferroni method, revealed that increased levels of CD66b + + myeloid cells (Odds Ratio [OR] = 0.945, 95% Confidence Interval [CI]: 0.916–0.974, P = 0.0002, PBonferroni= 0.0089), BAFF-R on IgD- CD38br B cells (OR = 0.919, 95% CI: 0.873–0.966, P = 0.001, PBonferroni = 0.0365), and CD39 on CD39 + CD8br regulatory T cells (OR = 0.927, 95% CI: 0.890–0.966, P = 0.0003, PBonferroni = 0.0116) play a protective role against sepsis, as determined by the inverse variance weighted (IVW) method. Our findings did not reveal any significant impacts of sepsis on immunophenotypes.
Conclusions
This study highlights the potential protective roles of CD66b + + myeloid cells, BAFF-R on IgD- CD38br B cells, and CD39 on CD39 + CD8br regulatory T cells against sepsis. These insights advance our understanding of the immune system's interaction with sepsis risk and propose new avenues for immunotherapy-oriented interventions.
Adaptive Admittance Flexible Control Based on a Fuzzy Predictor for Active Suspension with Electrohydraulic Actuators
Authors: Yang Mengke , Liu Shuang , Zhao Dingxuan , Ding Honggang 
Published: April 2024

Abstract

This paper presents an adaptive admittance flexible control approach for a multi-axle heavy-duty wheeled vehicle (MHWV) equipped with an electrohydraulic actuator active suspension. The proposed method aims to enable flexible interaction control between the vehicle and uneven roads, enhancing the load-bearing stability and ride comfort of the MHWV over rough terrain. To reduce the effects of nonlinearity in the hydraulic system and uncertainties in the environmental stiffness on the force-tracking performance during interaction control, an adaptive fuzzy predictor (AFP) is proposed in this study for the nonlinear identification of the hydraulic suspension systems. The predictor is employed to estimate the nonlinear relationship between the output force of the hydraulic actuator and its relative displacement during vehicle-road interactions, thus enabling multistep-ahead prediction of the actuator output force. The Levenberg-Marquardt optimization algorithm is used to produce an adaptive admittance controller with precise force-tracking performance by optimizing and adaptively adjusting the admittance controller parameters based on the output force errors and the desired force within the prediction range. Finally, the validity of the AFP is confirmed on a three-axle heavy-duty wheeled experimental prototype (THWEP). The results of the vehicle experiments indicate that the proposed method has better force-tracking performance than does the conventional constant-parameter admittance controller. Thus, the ride comfort, load-bearing stability, and ability to retain the attitude of the THWEP are enhanced.
To assess the clinical effectiveness of unilateral biportal endoscopy (UBE) and uniportal endoscopy (UE) in the management of lumbar spinal stenosis.
Authors: 江 高 , 翔宇 孟 
Published: April 2024

Abstract
Purpose To assess the clinical effectiveness of unilateral biportal endoscopy (UBE) and uniportal endoscopy (UE) in the management of lumbar spinal stenosis.
Methods Retrospective analysis was done on the clinical records of 61 patients with lumbar spinal stenosis treated with UBE or UE in the minimally invasive spine surgery department of the Sixth Affiliated Hospital of Xinjiang Medical University between January 2023 and January 2024. The patients' average age was 66.4±12.5, and they included 24 males and 37 females. Using various surgical techniques, the patients were split into two groups: the UE group (33 cases) and the UBE group (28 cases). In order to assess the treatment scores, data on the two groups' operational times, intraoperative blood loss, visual analogue scales (VAS), and 0swestry Disability Index (0DI) were gathered and compared. The area of the dural sac and the angle of facet joint resection were determined based on preoperative and postoperative MRI and CT scans, and the problems were noted.
Results Every patient had a successful surgical procedure.The intraoperative blood loss in the UBE group was 79.8±17.2ml, and the operative time was 68.7±9.8min.The group's UE was 71.5±10.8min and 73.5±21.7ml, respectively. There was no statistically significant difference between the groups (p>0.05).The two groups' post-operative VAS and ODI scores were lower than their pre-operative scores and exhibited a persistent downward trend. No statistically significant differences were found between the groups (p>0.05) in the variance analysis of the repeated measurement design.At the most recent follow-up, the rate of good and good showed no statistical significance (P>0.05).The dural sac area was (103.25±35.16) mm2 in the UE group and (126.73±42.74) mm2 in the UBE group (P<0.02).In the UBE group, the angle of lateral facet arthrotomy was 77.92°±12.17°, but in the UE group, it was 95.48°±11.98° (P<0.000).
Conclusion Both UBE and UE have good short-term clinical efficacy in treating lumbar spinal stenosis; however, UBE has a better imaging decompression effect and can better preserve zygapophysial joint.
Role of salivary proteins on radiation-related caries onset in head and neck cancer patients treated with radiotherapy - a longitudinal study.
Authors: Agurto Maria Gonzalez , Bozorgi Sophie , Carpenter Guy , Ramirez Valeria , burke Mary , gutierrez Mario Felipe , Cordova Christian , Banerjee Avijit 
Published: April 2024

Abstract
Objective
Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients (HNC)up to one-year post intensity-modulated radiation therapy (IMRT).
Methods
Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT (T0), six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT and salivary parameters were quantified including flow rate, mucin 5B and 7, Immunoglobulin A (IgA), and cystatin S and α-amylase.
Results
45% patients had at least one carious lesion at T2, having a significant reduction in the number of remaining teeth (65% <21), salivary flow rate (<50%,) and, protein secretion (<0.05) post-IMRT. At T1 IgA concentration/secretion rate were associated with caries lesions (p<0.05). Finally, IgA and total protein concentration obtained at T1 could provide a predictive pattern (AUC 82.3%) for the patients more predisposed to developing RC at T2.
Conclusion
This study demonstrated the significant association of RC with salivary proteins in HNC patients treated with IMRT, revealing the potential role of salivary proteins in the early diagnosis of RC.
Clinical relevance: This research contributes to reveal salivary proteins association with RC, and its role in early diagnosis. Therefore, this could be the first step towards for personalized medicine approaches to improve this group quality of life (QoL).
Digital 2-year multidomain health interventions improve cognition and stabilize Alzheimer’s disease risk in at-risk adults (DC-MARVEL): A randomized controlled trial
Authors: Gray Michelle , Campitelli Anthony , Glenn Jordan , Gills Joshua , Jones Megan , Urbina Ray , Bryk Kelsey , Myers Jennifer , Paulson Sally , Kempkes Jenova , Helberg Katelyn 
Published: April 2024

Abstract

Alzheimer's disease and related dementias (ADRD) impose a substantial burden on quality of life among older adults, with healthcare costs totaling approximately $345 billion in 2023. Research suggests lifestyle-based interventions, such as health coaching (HC), are promising intervention strategies for reducing modifiable ADRD risk factors. In-person HC has demonstrated varying degrees of efficacy through behavioral modification strategies including personalized goal setting, education, and guidance. However, the effectiveness of a virtual HC program for reducing ADRD risk and modifying cognition among at-risk adults remains unexplored. The purpose of the Digital Cognitive Multidomain Alzheimer’s Risk Velocity (DC-MARVEL) randomized controlled clinical trial was to evaluate the effectiveness of a two-year virtual HC intervention and an enhanced virtual health education (HE) intervention among adults at-risk for ADRD. There were no significant differences between the HC intervention and HE in overall ADRD risk over time; however, a sub analysis of older adults (65+) revealed significant improvement in risk scores among HC participants. Both groups improved in several cognitive domains. Results of this study support the advantages of lifestyle-based interventions in mitigating ADRD risk. It also demonstrates the efficacy of both virtual HC and structured HE protocols to stabilize ADRD risk and promote improvements in cognition among at-risk adults.
T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing
Authors: Xiong Yulong , Zhang Zhenhao , Liu Shangyu , Shen Lishui , Zheng Lihui , Ding Ligang , Liu Limin , Wu Lingmin , Hu Zhicheng , Li Le , Hu Zhao , Zhang Zhuxin , Zhou Likun , Xu Mengtong , Yao Yan 
Published: April 2024

Abstract
Utilizing small interfering RNA (siRNA) for gene silencing presents a viable strategy for treating human diseases, including cardiovascular disorders. However, the strategic targeting and delivery of siRNA therapeutics to desired tissues or cell subtypes, followed by endosomal escape into the cytosol, remain challenging. Based on previous research, we identified interferon regulatory factor 1 (IRF1)-mediated macrophage pyroptosis as a potential therapeutic target for myocarditis. Herein, a T lymphocyte-macrophage hybrid membrane-coated zeolitic imidazolate framework-8 (ZIF-8) nano-delivery platform was fabricated for the precise conveyance of siRNA against IRF1 (siIRF1) to the pro-inflammatory M1 macrophages in myocarditis (siIRF1@ZIF@HM). The siIRF1-loaded ZIF-8 nanoparticle exhibited a high siRNA loading capacity and efficient endo-lysosomal escape ability. The application of hybrid membrane coating significantly improved M1 macrophage targeting both in vivo and in vitro. Delivery of siIRF1 effectively suppressed IRF1 expression and concomitantly inhibited pyroptosis in IFN-γ-stimulated macrophages. Consequently, the siIRF1 nanotherapeutic approach demonstrated the potential to attenuate myocardial inflammation and mitigate the progression of myocarditis. Our study reveals that the customized biomimetic nano-delivery system holds great prospects in the treatment of inflammatory diseases.
Psychophysiological effects of walking in forests and urban built environments with disparate road traffic noise exposure: study protocol of a randomized controlled trial
Authors: Schaupp Julia , Hediger Karin , Wunderli Jean-Marc , Schäffer Beat , Tobias Silvia , Kolecka Natalia , Bauer Nicole 
Published: April 2024

Abstract

Background
Stress is a widespread phenomenon and reality of everyday life, entailing negative consequences for physical and psychological wellbeing. Previous studies have indicated that exposure to greenspaces and nature-based interventions are promising approaches to reducing stress and promoting restoration. However, an increasing percentage of the population lives in urban regions with limited opportunities to spend time in greenspaces. In addition, urban settings typically feature increased levels of noise, which represents a major environmental stressor. Although various studies have compared the effects of exposure to greenspaces versus urban built environments, evidence of the effects of noise in this context is very limited. Psychophysiological benefits of exposure to greenspaces compared to urban built environments reported in earlier studies might be less (or at least not only) due to features of the greenspaces than to additional stressors, such as road traffic noise in the urban built environment. Hence, differences in the effects attributed to greenness in previous studies may also be due to potentially detrimental noise effects in comparison settings. This paper reports the study protocol for a randomized, controlled intervention study comparing the effects of walking in forest versus urban built environments, taking road traffic noise exposure during walks in the respective settings into account.
Methods
The protocol envisages a field study employing a pretest-posttest design to compare the effects of 30-minute walks in urban built environments and forests with different road traffic noise levels. Assessments will consist of self-reported measures, physiological data (salivary cortisol and skin conductance), an attention test, and noise, as well as greenness measurements. The outcomes will be restoration, stress, positive and negative affect, attention, rumination, and nature connectedness.
Discussion
The results will inform about the restorative effect of walking in general, of exposure to different types of environments, and to different noise levels in these sites. The study will provide insights into the benefits of walking and nature-based interventions, taking into account the potential detrimental effects of noise exposure. It will thus facilitate a better understanding of low-threshold interventions to prevent stress and foster wellbeing.
Trial registration:
ISRCTN48943261, https://doi.org/10.1186/ISRCTN48943261; Registered 23.11.2023.
Performance Analysis of Grid-Connected Photovoltaic Systems in Dhaya Algeria
Authors: Bouroumeid yassine , Jbilou Mokhtaria , BECHEKIR Seyf Eddine , Nemmich Said , Ghaitaoui Essama Ahmed , Brahami Mostefa 
Published: April 2024

Abstract

The escalating demand for electricity driven by population growth has strained Algeria's power stations to boost their output. With the significant decline in solar photovoltaic (SPV) electricity prices and the escalating tariffs on conventional electricity, there has been a growing interest in solar photovoltaic plants for electricity generation. Consequently, accurately evaluating the annual and monthly yield of SPV plants becomes crucial for designing and installing new facilities. This paper presents an assessment of a 12 MW grid-connected photovoltaic power plant situated in the Dhaya region of Sidi Bel Abbes, Algeria. Real-time observational data was collected from January 1st, 2023, to December 2023. Evaluated parameters include energy output, final yield, performance ratio (PR), among others. The power plant supplied 20780.67 MWh to the grid in 2023. The final yield (Yf) ranged from 3.25 to 5.88 kWh/kWp, the performance ratio (PR) varied from 79% to 89.71%, and the annual capacity factor was determined to be 19.44%. These parameters are compared with those obtained from simulations using PVsyst software and solar GIS-PV planner.
Effectiveness of primary care-based chronic disease management program on glycated hemoglobin levels
Authors: Kim Juan , Yun Il , Park Eun-Cheol , Ha Min Jin 
Published: April 2024

Abstract
Background: Diabetes is one of the most common causes of cardiovascular disease and has led to death over time. For better management of glycated hemoglobin levels, which is a well-known index in diagnosing diabetes, many countries have been launching chronic disease management programs. Therefore, this study aimed to evaluate the effectiveness of the primary care-based chronic disease management integrated pilot program (PCDMP) in controlling glycated hemoglobin (HbA1c) levels in Korea. Nation-wide data from the 2019–2021 Korea National Health and Nutrition Examination Survey were used.
Methods: We analyzed nationwide health examination data combined with various regional data sources. Using appropriate inclusion criteria for this study, a total of 13,901 individuals were suitable for the analysis. A generalized linear mixed model was applied to consider the clustered structure of the regional level data, where individual-level data, containing demographic characteristics and health-related information, were nested.
Results: Individuals living in areas with a low PCDMP participation (< 30.37%) had odds (95% CI, 1.08–1.82) of exhibiting glycated hemoglobin levels ≥ 6.5% greater than did those residing in areas with a high PCDMP participation (≥ 30.37%). According to the stratified analysis of HbA1c levels, people residing in areas with low PCDMP participation had significantly greater odds of having an HbA1c > 6.5%, which may indicate diabetes mellitus.
Conclusion: The lower the number of internal medicine clinics in an area participating in PCDMP was, the greater the possibility of an HbA1c > 6.5%. Our findings advocate the need for the government to pay attention to chronic disease management programs, which may lead individuals to have normal HbA1c levels (< 6.5%).
Changing Characteristics of Young Suicide Attempters in Tokyo, Japan
Authors: Narishige Ryuichiro , Otaka Yasushi , Tateno Amane 
Published: April 2024

Abstract

Background
The number of young suicides in Japan has shifted from a decreasing trend to a flat or increasing trend since 2017. In order to identify the factors behind these changes, we investigated changes in the characteristics of young suicide attempters.
Methods
The subjects were suicide attempters under 30 years old who were admitted to the Critical Care Medical Center of Nippon Medical School Hospital between January 1, 2010 and December 31, 2021. They were divided into two groups, one for pre-2017, and the other for post-2017. The means of suicide attempt, sociodemographic data, psychiatric diagnoses, and causes and motives of suicide attempts were retrospectively examined from medical records, and the two groups were compared and statistically analyzed.
Results
The proportion of suicide attempters under 30 years old was 27.9% (143 of 513) before 2017, compared to 38.0% (132 of 347) after 2017, with a significant increase in the latter group. There was a significant increase in the number of suicide attempters under 30 years old from 2017 to 2021 with respect to females and the percentage of drug overdoses, but no significant changes were observed in regard to employment status, residential status, history of self-harm, history of psychiatric consultation, psychiatric diagnosis, and causes and motives for suicide attempts.
Conclusions
As well as in young suicides, trend changes were observed between 2010–2016 and 2017–2021 with respect to suicide attempts by people under 30 years old, suggesting that the changes may be related to an increase in drug overdoses. It may be necessary to impose regulations on the ease with which information about drug overdoses can be obtained.