bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella
Authors: Geng Xin-Yan , Jin Hui-Juan , Xia Lan , Wang Bin-Bin , Chen Su-Ren 
Published: March 2024

AbstractTektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is proposed to be localized at the center of the tektin bundle and hypothesized to recruit tektins or stabilize the bundle. However, the physiological role of TEKTIP1 is unknown. In this study, we generated Tektip1-knockout (Tektip1−/−) mice and showed that they were male subfertile primarily due to reduced sperm motility. A high percentage of sperm from Tektip1−/− mice showed moderately disorganized axoneme structures and abnormal flagellar waveforms. TEKTIP1 predominately interacted with TEKT3 among tektins. Loss of TEKTIP1 partially disturbed the organization of tektin bundle by mainly affecting the native status of TEKT3 and its interaction with other tektins. Collectively, our study reveals the physiological role and potential molecular mechanism of TEKTIP1 in axonemal structure and sperm motility, highlights the importance of MIPs in stabilizing DMTs, and suggests a potential relevance of TEKTIP1 deficiency to human asthenospermia. Tektip1−/− mice will be an excellent animal model to study the DMT organization of sperm flagella using cryo-EM in future.
Balloon endoscopy-assisted endoscopic retrograde cholangiopancreatography for hepatolithiasis in patients with hepaticojejunostomy
Authors: Hakuta Ryunosuke , Sato Tatsuya , Nakai Yousuke , Kogure Hirofumi , Nishio Hiroto , Kurihara Kouhei , Tange Shuichi , Fukuda Rintaro , Takaoka Shinya , Suzuki Yukari , Oyama Hiroki , Kanai Sachiko , Noguchi Kensaku , Suzuki Tatsunori , Ishigaki Kazunaga , Saito Tomotaka , Hamada Tsuyoshi , Takahara Naminatsu , Fujishiro Mitsuhiro 
Published: March 2024

Abstract
Background and aim
Balloon endoscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP) is an emerging procedure for pancreatobiliary diseases in patients with surgically altered anatomy. However, data on BE-ERCP for hepatolithiasis after hepaticojejunostomy (HJS) are still limited.

Methods
Stone removal success, adverse events and recurrence were retrospectively studied in consecutive patients who underwent BE-ERCP for hepatolithiasis after HJS between January 2011 and October 2022. Subgroup analysis was performed to compare clinical outcomes between patients who had undergone HJS over 10 years before (past HJS group) and within 10 years (recent HJS group).

Results
A total of 131 patients were included; 39% had undergone HJS for malignancy and 32% for congenital biliary dilation. Scope insertion and complete stone removal were successful in 89% and 73%, respectively. Early adverse events were observed in 9.9%. Four patients (3.1%) developed gastrointestinal perforation but could be managed conservatively. Hepatolithiasis recurrence rate was 17%, 20% and 31% in 1-year, 3-year, and 5-year after complete stone removal. The past HJS group was the only risk factor for failed stone removal (odds ratio 10.4, 95% confidence interval 2.99–36.5) in the multivariable analysis. Failed scope insertion (20%) and failed guidewire or device insertion to the bile duct (22%) were two major reasons for failed stone removal in the past HJS group.

Conclusions
BE-ERCP for hepatolithiasis was effective and safe in cases with HJS but the complete stone removal rate was low in the past HJS group. Recurrent hepatolithiasis was common and careful follow up study is needed even after complete stone removal.
Remarks on the Levi core
Authors: Dall’Ara Gian Maria , Mongodi Samuele 
Published: March 2024

AbstractWe investigate a few aspects of the notion of Levi core, recently introduced by the authors in Dall’Ara, Mongodi (J l’École Polytech Math 10:1047-1095, 2023): a basic finiteness question, the connection with Kohn’s algorithm, and with Catlin’s property (P).
Uniform Turnpike Property and Singular Limits
Authors: Hernández Martín , Zuazua Enrique 
Published: March 2024

AbstractMotivated by singular limits for long-time optimal control problems, we investigate a class of parameter-dependent parabolic equations. First, we prove a turnpike result, uniform with respect to the parameters within a suitable regularity class and under appropriate bounds. The main ingredient of our proof is the justification of the uniform exponential stabilization of the corresponding Riccati equations, which is derived from the uniform null control properties of the model.Then, we focus on a heat equation with rapidly oscillating coefficients. In the one-dimensional setting, we obtain a uniform turnpike property with respect to the highly oscillatory heterogeneous medium. Afterward, we establish the homogenization of the turnpike property. Finally, our results are validated by numerical experiments.
The Effect of Stigma on Family Planning and HIV Pre-exposure Prophylaxis Decisions of Young Women Accessing Post-Abortion Care in Kenya
Authors: Zia Yasaman , Etyang Lydia , Mwangi Margaret , Njiru Roy , Mogaka Felix , June Lavender , Njeru Irene , Makoyo Job , Kimani Susan , Ngure Kenneth , Wanyama Inviolata , Bukusi Elizabeth , Nyerere Bernard , Nyamwaro Cyprian , Mugo Nelly , Heffron Renee ,   PrEDIRA team, Peacock Sue , Thomas Kathy , Odoyo Josephine , Mwangi Florence 
Published: March 2024

AbstractAdolescent girls and young women (AGYW) in Eastern and Southern Africa face parallel epidemics of unintended pregnancy and HIV. Their sexual health decisions are often dominated by intersecting stigmas. In an implementation science project integrating delivery of daily, oral pre-exposure prophylaxis (PrEP) for HIV prevention into 14 post-abortion care (PAC) clinics in Kenya, we enrolled a subset of PrEP initiating AGYW (aged 15 to 30 years) into a research cohort. Utilizing log binomial models, we estimated the effect of PrEP stigma on PrEP continuation (measured via self-report and urine assay for tenofovir) and abortion stigma on contraceptive initiation. Between April 2022 and February 2023, 401 AGYW were enrolled after initiating PrEP through their PAC provider, of which 120 (29.9%) initiated highly-effective contraception. Overall, abortion and PrEP stigmas were high in this cohort. Abortion stigma was more prevalent among those that were adolescents, unmarried, and reported social harm. Among 114 AGYW returning for the month 1 follow-up visit, 83.5% reported continuing PrEP and 52.5% had tenofovir detected. In this subset, higher levels of PrEP stigma were significantly associated with greater likelihood of PrEP adherence, but not PrEP continuation. For abortion stigma, greater scores in the subdomain of isolation were significantly associated with greater likelihood of initiating a highly-effective contraception, while greater scores in the subdomain of community condemnation were significantly associated with reduced likelihood of initiating a highly-effective contraception. Given the burden of stigma documented by our work, PAC settings are a pivotal space to integrate stigma-informed counseling and to empower young women to optimize contraceptive and PrEP decisions.
3D point cloud-based place recognition: a survey
Authors: Luo Kan , Yu Hongshan , Chen Xieyuanli , Yang Zhengeng , Wang Jingwen , Cheng Panfei , Mian Ajmal 
Published: March 2024

AbstractPlace recognition is a fundamental topic in computer vision and robotics. It plays a crucial role in simultaneous localization and mapping (SLAM) systems to retrieve scenes from maps and identify previously visited places to correct cumulative errors. Place recognition has long been performed with images, and multiple survey papers exist that analyze image-based methods. Recently, 3D point cloud-based place recognition (3D-PCPR) has become popular due to the widespread use of LiDAR scanners in autonomous driving research. However, there is a lack of survey paper that discusses 3D-PCPR methods. To bridge the gap, we present a comprehensive survey of recent progress in 3D-PCPR. Our survey covers over 180 related works, discussing their strengths and weaknesses, and identifying open problems within this domain. We categorize mainstream approaches into feature-based, projection-based, segment-based, and multimodal-based methods and present an overview of typical datasets, evaluation metrics, performance comparisons, and applications in this field. Finally, we highlight some promising research directions for future exploration in this domain.
The Psychology of Kink: A Cross‐Sectional Survey Investigating the Association Between Adult Attachment Style and BDSM-Related Identity Choice in China
Authors: Li Shengyu 
Published: March 2024

AbstractBDSM is a type of sexual preference that includes bondage and discipline, dominance and submission, and sadism and masochism. Research has identified three specific power exchange roles in the practice of BDSM: dominance, submission, and switch. It has also been suggested that attachment style potentially influences BDSM interests. This study investigated the potential roles of attachment style in driving BDSM identity. A questionnaire was completed by a cross-sectional Chinese sample (n = 3310, age range 18–30 years), including 1856 BDSM practitioners (436 men, 1420 women). To assess attachment style, the questionnaire included a Chinese translation of the Adult Attachment Scale as well as items surveying BDSM interests. Compared to non-BDSM practitioners, attachment styles were not significantly different from BDSM practitioners. However, practitioners with different BDSM identities showed a significant difference in their attachment styles. Secure and avoidant attachment styles were associated with dominance, whereas submissiveness recorded high average scores of separation anxiety in both males and females. BDSM identities based on gender revealed that 60.5% of female practitioners assumed the role of submissiveness and this group recorded the highest average scores of separation anxiety among all groups. These results show that BDSM identity is related to attachment style. However, the results did not support the hypothesis that attachment styles potentially drive BDSM identities. Further research is needed to explore other psychological processes that drive BDSM identities in order to provide guidance for BDSM practitioners in choosing suitable identities, thereby helping practitioners to choose suitable identity partners and avoid negative experiences during BDSM participation.
Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypes
Authors: Garcia-Torralba Esmeralda , Pérez Ramos Miguel , Ivars Rubio Alejandra , Navarro Manzano Esther , Blaya Boluda Noel , Lloret Gil Miguel , Aller Alberto , de la Morena Barrio Pilar , García Garre Elisa , Martínez Díaz Francisco , García Molina Francisco , Chaves Benito Asunción , García-Martínez Elena , Ayala de la Peña Francisco 
Published: March 2024

Abstract
Purpose
The prognostic utility and biological correlates of neutrophil to lymphocyte ratio (NLR), a potential biomarker of the balance between immune response and the inflammatory status, are still uncertain in breast cancer (BC).

Methods
We analysed a cohort of 959 women with early breast cancer, mostly treated with neoadjuvant or adjuvant chemotherapy. Clinical and pathological data, survival, NLR (continuous and categorical) and stromal tumor infiltrating lymphocytes (sTIL) were evaluated.

Results
NLR was only weakly associated with Ki67, while no association was found for grade, histology, immunohistochemical subtype or stage. Lymphocyte infiltration of the tumor did not correlate with NLR (Rho: 0.05, p = 0.30). These results were similar in the whole group and across the different BC subtypes, with no differences in triple negative BC. Relapse free interval (RFI), breast cancer specific survival (BCSS) and overall survival (OS) changed according to pre-treatment NLR neither in the univariate nor in the multivariate Cox models (RFI: HR 0.948, p = 0.61; BCSS: HR 0.920, p = 0.57; OS: HR 0.96, p = 0.59).

Conclusion
These results question the utility of NLR as a prognostic biomarker in early breast cancer and suggest the lack of correlation of NLR with tumor microenvironment immune response.
How do sensemaking and climate change education affect climate engagement at the grassroots level? A study of five communities in Southeastern Ghana
Authors: Adobor Henry 
Published: March 2024

AbstractThis study aims to explore how climate change education and sensemaking can lead to climate engagement and adaptive behavior at the grassroots level. The research focuses on five rural communities in Ghana and seeks to answer three key questions related to how people understand and respond to climate change issues. One strength of the study is the use of sensemaking as an organizing framework, which allows for a nuanced understanding of how people at the grassroots level make sense of complex environmental issues like climate change. The study findings suggest that sensemaking was a critical factor in how people noticed and made meaning of the climate crisis, and that deliberative tools like storytelling, conversation, and listening were important tools for facilitating this process. We also found that climate educators needed to address existing misconceptions before framing climate change issues in terms of science and impact on livelihoods. Linking climate change to rural livelihoods resonated more with people than science, and a strategy of guiding communities to recognize the need for adaptive behavior through individual and collective sensemaking was important. The emphasis on linking climate change to rural livelihoods rather than science is an important finding, as it suggests that approaches that emphasize the impact of climate change on local communities and their ability to adapt may be more effective than purely scientific arguments.
Electroretinographic oscillatory potentials in Leber hereditary optic neuropathy
Authors: Barboni Mirella T. S. , Sustar Habjan Maja , Petrovic Pajic Sanja , Hawlina Marko 
Published: March 2024

Abstract
Purpose
Leber hereditary optic neuropathy (LHON) affects retinal ganglion cells causing severe vision loss. Pattern electroretinogram and photopic negative response (PhNR) of the light-adapted (LA) full-field electroretinogram (ERG) are typically affected in LHON. In the present study, we evaluated dark-adapted (DA) and LA oscillatory potentials (OPs) of the flash ERG in genetically characterized LHON patients to dissociate slow from fast components of the response.

Methods
Seven adult patients (mean age = 28.4 ± 5.6) in whom genetic diagnosis confirmed LHON with mtDNA or nuclear DNAJC30 (arLHON) pathogenic variants were compared to 12 healthy volunteers (mean age = 35.0 ± 12.1). Full-field ERGs were recorded from both eyes. Offline digital filters at 50, 75 and 100 Hz low cutoff frequencies were applied to isolate high-frequency components from the original ERG signals.

Results
ERG a-waves and b-waves were comparable between LHON patients and controls, while PhNR was significantly reduced (p = 0.009) in LHON patients compared to controls, as expected. OPs derived from DA signals (75 Hz low cutoff frequency) showed reduced peak amplitude for OP2 (p = 0.019). LA OP differences between LHON and controls became significant (OP2: p = 0.047, OP3: p = 0.039 and OP4: p = 0.013) when the 100 Hz low-cutoff frequency filter was applied.

Conclusions
Reduced OPs in LHON patients may represent disturbed neuronal interactions in the inner retina with preserved photoreceptoral (a-wave) to bipolar cell (b-wave) activation. Reduced DA OP2 and high-cutoff LA OP alterations may be further explored as functional measures to characterize LHON status and progression.
Investigating the “Thief in the Night”: The Reproduction and Erosion of Indigenous Forms of Social Resilience in Rural Fiji
Authors: Singh-Peterson Lila , Iranacolaivalu Manoa 
Published: March 2024

AbstractAcross the Republic of Fiji, the combination of slow onset climate change and extreme weather events continues to wreak havoc. In addition to direct damages sustained from climate impacts, the uncertainties associated with changes to natural systems in combination with depletion of natural resources and declines in biodiversity provide substantial challenges for Indigenous cultures and rural semi-subsistence livelihoods. Consequently, the concept of social resilience in terms of peoples’ capacities to cope and adapt to social and ecological changes remains important. In this study, we examine local Indigenous systems of social resilience constructed in alignment with the traditional value of relationalism, and concomitant practices of solesolevaki (working together) and kerekere (requesting, gifting, sharing) to (i). understand how social resilience in this local setting is both reproduced and sustained, and (ii).to examine how moral conflicts and ambiguities arising between traditional modes of living and being, and newer, introduced ontologies attributed to late liberalism are affecting social resilience. We present an ethnographic sketch drawn from fieldwork observations and narratives undertaken in rural Fiji since 2016 and apply Robbins’ (2017) theorising of culture and values to examine how people reconcile competing value systems attached to two porous social orders that structure the practices and rhythms of daily life, which Merlan (2005) refers to as the intercultural.
µSR studies for radical reactions of unsaturated organophosphorus compounds
Authors: Ito Shigekazu 
Published: March 2024

AbstractIn this paper, the µSR studies of some unsaturated organophosphorus compounds containing heavier congeners of cyclobutane-1,3-diyl and anthracene are reviewed by discussing the usefulness of µSR for main group chemistry. The regioselective addition of muonium (Mu = [µ+e–]) to one of the skeletal phosphorus atoms in an electron-donating air-stable crystalline 1,3-diphosphacyclobutane-2,4-diyl leading to the paramagnetic 4-membered P-heterocycle was characterized by the Δ1 (ΔM =  ± 1) resonance signal observed by muon (avoided) level-crossing resonance (µLCR). Meanwhile, a crystalline 1,3-diphosphacyclobutane-2,4-diyl bearing an electron-deficient nitrogen heterocyclic unit was analyzed by transverse-field muon spin rotation (TF-µSR) to characterize predominant muoniation at the skeletal radical carbon centre. A 9-phosphaanthracene bearing the trifluoromethyl (CF3) stabilizing groups at the peri positions was also investigated from the views of radical reactivity, and the regioselective addition of muonium to the skeletal sp2-type phosphorus atom was characterized by the muon hyperfine coupling (hfc) constant observed by TF-µSR and the Δ0 (ΔM = 0) signal of µLCR. The light mass of muon (Mass = 0.1134 amu) causes the larger zero-point energy and promotes the high-energy molecular structure in which the fused aromatic rings are almost flat, although the CF3 groups would prefer the non-planar saddle-like 9-phosphaanthracene skeleton.
Analysis of cell growth, photosynthetic behavior and the fatty acid profile in Tetraselmis subcordiformis under different lighting scenarios
Authors: Montoya Montoya Laura María , Pérez Andrés Alonso Arbeláez , Giraldo Calderón Néstor David , Garcés Lucía Atehortúa 
Published: March 2024

AbstractTetraselmis has been investigated as a potential source of lipids. This microalga possesses good growth characteristics and can be used to develop viable platforms for fatty acid production. This research aims to evaluate the effect of high photon flux density with light-dark cycles and light wavelength on biomass production and fatty acid profile in Tetraselmis subcordiformis. A low light control and treatments with high photon flux density with different light-dark cycles (24:0 h, 12:12 h, 1:1 h, and 15:15 min) and different light wavelength (white, green, red, and blue) were evaluated to determine cell concentration, nutrient consumption, chlorophyll content, photosynthetic yields, lipid content, and fatty acid profile. Significant differences were found in all variables, except for phosphate consumption. High photon flux density promotes cell growth with T. subcordiformis reaching biomass productivities of 0.10 g L-1 day-1 when continuous white light is used. However, no differences were observed in biomass productivities and lipid content for all high photon flux density treatments. On the other hand, red light resulted in higher cell growth, with a productivity of 0.12 g L-1 day-1, and the highest lipid content was achieved under white light. There was a significant effect on the fatty acid profile under different light conditions, with palmitic acid, oleic acid, and eicosapentaenoic acid being the most abundant. This study demonstrated that cellular growth and fatty acid profiles in T. subcordiformis can be influenced by different lighting schemes in the cultivation.
Involvement of IL-17 A/IL-17 Receptor A with Neutrophil Recruitment and the Severity of Coronary Arteritis in Kawasaki Disease
Authors: Lin I-Chun , Suen Jau-Ling , Huang Shau-Ku , Chou Ming-Hui , Kuo Hsuan-Chang , Lo Mao-Hung , Kuo Kuang-Che , Wang Lin 
Published: March 2024

Abstract
Purpose
To assess the role of the interleukin (IL)-17 A/IL-17 receptor A (IL-17RA) in Kawasaki disease (KD)-related coronary arteritis (CA).

Methods
In human study, the plasma levels of IL-17 A and coronary arteries were concurrently examined in acute KD patients. In vitro responses of human coronary endothelial cells to plasma stimulation were investigated with and without IL-17RA neutralization. A murine model of Lactobacillus casei cell-wall extract (LCWE)-induced CA using wild-type Balb/c and Il17ra-deficient mice were also inspected.

Results
The plasma levels of IL-17 A were significantly higher in KD patients before intravenous immunoglobulin therapy, especially in those with coronary artery lesion. The pre-IVIG IL-17 A levels positively correlated with maximal z scores of coronary diameters and plasma-induced endothelial mRNA levels of chemokine (C-X-C motif) ligand-1, IL-8, and IL-17RA. IL-17RA blockade significantly reduced such endothelial upregulations of aforementioned three genes and inducible nitric oxide synthase, and neutrophil transmigration. IL-17RA expression was enhanced on peripheral blood mononuclear cells in pre-IVIG KD patients, and in the aortic rings and spleens of the LCWE-stimulated mice. LCWE-induced CA composed of dual-positive Ly6G- and IL-17 A-stained infiltrates. Il17ra-deficient mice showed reduced CA severity with the fewer number of neutrophils and lower early inducible nitric oxide synthase and chemokine (C-X-C motif) ligand-1 mRNA expressions than Il17ra+/+ littermates, and absent IL-17RA upregulation at aortic roots.

Conclusion
IL-17 A/IL-17RA axis may play a role in mediating aortic neutrophil chemoattraction, thus contributory to the severity of CA in both humans and mice. These findings may help to develop a new therapeutic strategy toward ameliorating KD-related CA.