bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sangre Por Salud (SPS) Biobank: cohort profile
Authors: Zarrugh Emmil , Girardo Marlene E , Ryu Euijung , Bielinski Suzette , Moreno Garzon Giovanna , Hernandez Valentina , Singh Davinder , Levey Sharon , Gonzalez Crystal , Pompa Daniela B , Meagher Karen , Sharp Richard R , Shaibi Gabriel Q , Mandarino Lawrence , Thibodeau Steven , Cerhan James R , Olson Janet E , De Filippis Elena 
Published: February 2025

PurposeThe Sangre Por Salud (SPS) Biobank was established to facilitate biomedical research opportunities for the Latino community by creating an easily accessible prospective cohort for scientists interested in studying health conditions and health disparities in this population.ParticipantsIndividuals self-identifying as Latino, aged 18–85 years, were prospectively recruited from the primary care Internal Medicine clinic at Mountain Park Health Center in Phoenix, Arizona. After obtaining informed consent, detailed medical history questionnaires were captured, and blood samples were obtained for common laboratory tests. Participants authorised the research team to access their electronic health records for research purposes. In addition, participants had serum, plasma and DNA samples isolated and stored at the Mayo Clinic Arizona Biorepository Laboratory for long-term storage and future access. As part of the study, participants consented and agreed to be contacted for potential participation in future research studies.Findings to date3756 participants provided informed consent, of whom 3733 completed all study questionnaires, an oral glucose tolerance test and had blood collected and stored. The SPS cohort is predominantly composed of females (72%), with a median age at time of consent of 42 years. All participants self-identified as Hispanic/Latino, 45% were married, 53% were employed for wages and 60% had less than a high school degree. Around 25% of participants met diagnostic criteria for overweight (BMI 25–29 kg/m2), and 49% met for obesity (BMI≥30 kg/m2). At time of recruitment, hypertension, hyperlipidaemia and depression affected 22%, 20% and 13% of the cohort, respectively.Future plansWe plan to regularly update the participants’ electronic health records and self-reported health data to longitudinal research. Additionally, we plan to obtain a more comprehensive genomic analysis on the entire cohort, ensuring greater research interest and investigation into the underlying genetic factors that contribute to disease susceptibility in this cohort.
Smartphone apps for mental health: systematic review of the literature and five recommendations for clinical translation
Authors: Almuqrin Aljawharah , Hammoud Ryan , Terbagou Ilham , Tognin Stefania , Mechelli Andrea 
Published: February 2025

ObjectivesProviding adequate access to mental health services is a global challenge. Smartphone apps offer a potentially cost-effective, available and accessible solution for monitoring, supporting and treating mental health conditions. This systematic review describes and evaluates the usage of smartphone apps across a wide range of mental health disorders in terms of clinical effectiveness, feasibility and acceptability.DesignThis is a systematic review of studies examining treatment, self-monitoring and multipurpose smartphone apps for mental health disorders.Data sourcesStudies were identified through a comprehensive search of the Ovid and PubMed databases. Articles published up to 14 January 2024 were included based on predefined criteria.Eligibility criteriaWe included randomised controlled trials that compared mental health apps (single- or multipurpose) with treatment-as-usual or no treatment for clinical populations with mental health disorders. Studies were excluded if they focused on web-based interventions, combined apps with non-TAU treatments or targeted physical health apps.Data extraction and synthesisTwo independent reviewers screened and selected studies, with a third reviewer resolving inconsistencies. Extracted data included study details, participant characteristics, app information and outcome measures related to effectiveness, feasibility and acceptability. A risk-of-bias assessment for each study was conducted.ResultsOut of 4153 non-duplicate articles screened, 31 studies met full-text eligibility criteria. These included 6 studies on treatment apps, 4 on self-monitoring apps and 21 on multipurpose apps for a range of mental health disorders. Fifteen were identified as having between some and high concern on the risk-of-bias assessment. While smartphone apps were generally effective and acceptable, their feasibility appeared to decline over time.ConclusionsSmartphone apps are promising tools for mental healthcare, demonstrating effectiveness and acceptability. However, challenges such as reduced feasibility over time, potential biases and underrepresented demographics require further research. This review proposes five recommendations for improving clinical translation in future studies.
Nurture-U student mental health longitudinal survey: a study protocol
Authors: Marshall Ellen , Duffy Anne C , Chamberlain Samuel R , Dooley Jemima , Dorey Lucy , Forty Liz , Matlock Kevin A , Newbold Alexandra , Quinn Anthony , Rees Sarah , Robinson Lucy J , Saunders Kate E , Watkins Edward R 
Published: February 2025

IntroductionUniversity life represents a critical period for young adults, providing opportunities for personal growth and development of coping skills but also posing significant mental health challenges. Recent trends indicate rising mental health concerns among university students, exacerbated by the COVID-19 pandemic and its aftermath. This study aims to address gaps in longitudinal data on student mental health in the UK and to identify risk and protective factors across diverse student populations.Methods and analysisThe current Nurture-U survey is developed from the U-Flourish biannual survey study piloted at Queen’s and Oxford universities in Canada and the UK, respectively. Nurture-U is a longitudinal survey study conducted at five UK universities, aiming to create a comprehensive data set from over 5000 students. The study will collect data at the start and completion of each academic year, using validated measures to assess well-being, mental health symptoms, lifestyle factors and access to support. Recruitment will target all students, with an emphasis on first-year students, to track their mental health trajectory from university entry through subsequent years.Ethics and disseminationEthical approval has been obtained from relevant committees at each participating university. Students will provide informed consent prior to participation, with risk messages and support information provided for those indicating self-harm or suicidal thoughts. Data will be de-identified and securely stored, with results disseminated through academic publications, social media and student engagement activities.
Cognitive behavioural therapy plus Kiesler Circle Training (CBT+) versus CBT only for patients with interpersonal problems: study protocol for a randomised controlled feasibility trial
Authors: Ollrogge Karen , Schulze Daniel , Sterzer Philipp , Köhler Stephan , Friedel Eva , Romanczuk-Seiferth Nina , Siegerist Anna-Lena , Brakemeier Eva-Lotta , Guhn Anne 
Published: February 2025

IntroductionInterpersonal problems are a transdiagnostic risk factor for the development and maintenance of various psychiatric disorders, including anxiety and depression. Interventions that address these interpersonal challenges could therefore play a crucial role in enhancing mental health. This study aims to evaluate the efficacy and feasibility of a transdiagnostic group intervention, the Kiesler Circle Training (KCT), in improving interpersonal skills.Methods and analysisIn a prospective randomised controlled trial (RCT), 156 outpatients with a primary diagnosis of either depression or anxiety disorder according to DSM-5, and significant interpersonal problems, will be investigated. All patients will receive individual, state-of-the-art cognitive behavioural therapy (CBT) during the study. They will be randomly assigned to one of two conditions: the experimental group will receive the KCT in group sessions, in addition to individual CBT, while the control group will receive only individual CBT. The KCT intervention consists of 1 introductory individual session and 12 weekly group sessions, each lasting 100 min, with groups of up to 10 patients. KCT includes five sequential modules: the interpersonal circle, nonverbal communication, verbal communication, conflict resolution and empathy training. It is hypothesised that the experimental group will show (a) greater reduction in interpersonal problems from pre-assessment to post-assessment and (b) greater symptomatic improvement regarding the primary diagnosis. Child maltreatment is expected to moderate the trajectory of interpersonal problems. This study aims to provide evidence for the feasibility of KCT as a modular transdiagnostic add-on approach for patients with interpersonal difficulties.Ethics and disseminationThis study obtained approval from the ethics committees at the Charité Berlin, the Medical School of Berlin and the University of Greifswald. All results will be disseminated through peer-reviewed articles in scientific journals and contributions to national and international conferences.Trial registration numberDRKS00032467,NCT06170801(see Supplementary Material).
Impact of prognostic nutritional index on mortality among patients receiving coronary artery bypass grafting surgery: a retrospective cohort study
Authors: Sun Lin , Liu Zihua , Cui Xueying , Hu Bo , Li Wei , Pan Yilin , Sun Yangyang , Wang Zikun , Dong Wanyue , Xu Kai , Han Lixiang , Zhang Yangyang , Zhao Xin , Li Zhi 
Published: February 2025

BackgroundThe Prognostic Nutritional Index (PNI), calculated from serum albumin levels and lymphocyte counts, is a simple and objective measure of nutritional status. While PNI has been shown to be a significant prognostic tool in gastrointestinal surgery and heart failure, its role in patients undergoing coronary artery bypass grafting (CABG) remains unclear. This study aims to evaluate whether PNI can serve as a meaningful risk factor for patients undergoing CABG.MethodsThis observational retrospective analysis involved a substantial sample of 2889 patients who underwent isolated CABG at one of four medical centres. The primary outcomes included short- and long-term mortality. Perioperative serum albumin levels and total lymphocyte counts used to calculate PNIs were collected 48 hours before the operation, 24 hours after the operation and at discharge. Univariate and multivariate logistic regression analyses were conducted to identify the risk factors of short-term mortality. Survival and relative risks were assessed using Cox regression analysis and the Kaplan-Meier test.ResultsAmong the 2889 patients, 64 (2.2%) died within 30 days following CABG. Multivariate logistic regression revealed that higher preoperative PNI was independently associated with reduced short-term mortality (OR=0.852 per unit increase, 95% CI 0.802 to 0.904, p<0.001). Regarding long-term outcomes, among the 2825 patients who were discharged alive, 199 deaths occurred over a median follow-up period of 54.9 months. Patients with a normal PNI at discharge (>40) exhibited significantly higher long-term survival rates compared with those with a lower PNI (≤40) (log-rank p=0.003). Multivariate Cox regression analysis confirmed that a normal PNI at discharge(>40) independently predicted a lower risk of long-term all-cause mortality (HR=0.718, 95% CI 0.529 to 0.974, p=0.033).ConclusionsPNI at various time points may play a crucial predictive role in mortality among CABG-treated patients, and a low PNI serves as a risk factor for both short- and long-term survival.
Concussion history and knowledge among top-level youth karate athletes
Authors: Augustovicova Dusana Cierna , Arriaza Rafael , Lystad Reidar P 
Published: February 2025

ObjectiveTo examine concussion experiences and knowledge among top-level youth karate athletes.MethodsThis cross-sectional study collected data during the 12th World Karate Championships for cadets, juniors and under-21 athletes (held in Konya, Turkey, 2022). All 1414 registered athletes from 95 countries were invited to complete a 16-item paper-based questionnaire assessing demographic data, concussion history and concussion knowledge prior to the competing at the tournament. χ2and Fisher’s exact tests were used to analyse differences by sex, age group and continental karate federation.ResultsA total of 654 athletes (46.3% response rate), including 286 (43.7%) females and 368 (56.3%) males, participated in the study, with 29.9% reporting one or more concussions during participation in karate training or competition. Older age groups (under 21 years) reported significantly higher concussion rates than younger athletes (56.9% vs 31.1% juniors and 24.7% cadets; p<0.001). Concussion knowledge revealed considerable gaps, with only 24.5% of athletes correctly identifying a concussion and 68.9% believing loss of consciousness was required for a concussion diagnosis. Misconceptions varied significantly across geographical regions, with Asian and African athletes demonstrating the greatest need for targeted education. Female athletes demonstrated better concussion reporting attitudes than males (60.4% vs 48.9%, p=0.004).ConclusionsThis study highlights the prevalence of concussions and significant knowledge gaps among top-level youth karate athletes, emphasising the need for tailored educational interventions to improve concussion recognition and management within the karate community.
Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma
Authors: Gordon Khloe S , Perez Caleb R , Garmilla Andrea , Lam Maxine S Y , Aw Joey J Y , Datta Anisha , Lauffenburger Douglas A , Pavesi Andrea , Birnbaum Michael E 
Published: February 2025

BackgroundChimeric antigen receptor (CAR) therapies have demonstrated potent efficacy in treating B-cell malignancies, but have yet to meaningfully translate to solid tumors. Nonetheless, they are of particular interest for the treatment of glioblastoma, which is an aggressive form of brain cancer with few effective therapeutic options, due to their ability to cross the highly selective blood-brain barrier.MethodsHere, we use our pooled screening platform, CARPOOL, to expedite the discovery of CARs with antitumor functions necessary for solid tumor efficacy. We performed selections in primary human T cells expressing a library of 1.3×106third generation CARs targeting IL-13Rα2, a cancer testis antigen commonly expressed in glioblastoma. Selections were performed for cytotoxicity, proliferation, memory formation, and persistence on repeated antigen challenge.ResultsEach enriched CAR robustly produced the phenotype for which it was selected, and one enriched CAR triggered potent cytotoxicity and long-term proliferation on in vitro tumor rechallenge. It also showed significantly improved persistence and comparable tumor control in a microphysiological human in vitro model and a xenograft model of human glioblastoma, but also demonstrated increased off-target recognition of IL-13Rα1.ConclusionTaken together, this work demonstrates the utility of extending CARPOOL to diseases beyond hematological malignancies and represents the largest exploration of signaling combinations in human primary cells to date.
Primary neuraxial anesthetic for elective total knee arthroplasty in patient with left ventricular assist device
Authors: Sheikh Hanin , Klein Julia Isabella , Higgins III Kenneth Elliott , Patton John W , Chu Benjamin 
Published: February 2025

BackgroundThere is a rising number of patients with left ventricular assist devices (LVADs) undergoing non-cardiac procedures, both emergent and elective. Historically, anesthetic options for these patients have been limited to general anesthesia. Limited data exists for the use of neuraxial anesthesia in patients with LVADs despite its common use in orthopedic procedures for non-LVAD patients. Given the benefits of neuraxial anesthesia and the rising population of LVAD patients undergoing elective procedures, a better understanding of LVAD patients’ candidacy for neuraxial anesthesia needs further investigation.Case presentationWe report the case of a patient with an LVAD who successfully underwent a total knee arthroplasty with neuraxial anesthesia at a tertiary academic center. Preoperative transthoracic echo demonstrated stable cardiac function and an ejection fraction of 10–15% with a HeartMate 3 LVAD. The primary anesthetic was a lumbar epidural that was slowly titrated to a surgical anesthetic level and an adductor canal peripheral nerve catheter was placed preoperatively for postoperative analgesia. The patient remained hemodynamically stable throughout the case, with a perfusionist monitoring the LVAD’s function intraoperatively, and tolerated the anesthetic well. His postoperative course was uneventful.ConclusionPatients with LVADs should be considered candidates for neuraxial anesthesia with appropriate preoperative planning and perioperative management.
Pharmacology of Intestinal Inflammation and Repair
Authors: Deraison Céline , Vergnolle Nathalie 
Published: February 2025

Chronic inflammation is a common trait in the pathogenesis of several diseases of the gut, including inflammatory bowel disease and celiac disease. Control of the inflammatory response is crucial in these pathologies to avoid tissue destruction and loss of intestinal function. Over the last 50 years, the identification of the mechanisms and mediators involved in the acute phase of the inflammatory response, which is characterized by massive leukocyte recruitment, has led to a number of therapeutic options. New drugs targeting inflammatory flares are still under development. However, interest on the other end of the spectrum—the resolution and repair phases—has emerged, as promoting tissue functional repair may maintain remission and counteract the chronicity of the disease. This review aims to discuss the current and future pharmacological approaches to the treatment of chronic intestinal inflammation and the restoration of functional tissues.
Navigating What Is Not Known—Patients’ Experience of the Life Threat Connected to Allogeneic Stem Cell Transplantation
Authors: Reimer Alinda , Schepers Carolin , Ley Merle , Schoerger Berenike , Pralong Anne , Voltz Raymond , Holtick Udo , Herling Marco , Simon Steffen T. 
Published: February 2025

Background: Allogeneic stem cell transplantation (allo‐SCT) represents a firmly established therapeutic option for patients facing (non‐)malignant haematological diseases. Despite its curative potential, however, this treatment is associated with substantial morbidity and mortality rates as well as a decreased quality of life. Given this context, a scientific void needs to be addressed: How do patients deal with the existential situation of being exposed to a life threat despite the curative potential of their treatment? This study aims to explore the patients’ experiences considering their life threat in the context of the allo‐SCT.Methods: Qualitative semistructured, in‐depth interviews were conducted with patients treated by allo‐SCT over the course of transplantation (before, during or after hospitalization). Interview data were interpreted using category‐based qualitative content analysis.Results: Seventeen interviews were conducted. Results revealed a strong focus on hope and avoidance of dealing with the life threat. At the same time, challenges due to the lack of alternative treatments and the uncertain course were highlighted. The data revealed that patients wished to receive support by healthcare professionals, their carers and their social environment in general. Beyond that, patients desired to obtain honest information within an open discussion about a realistic prognosis and risk of treatment and course of disease.Conclusion: The findings emphasize an interplay between hope, avoidance and psychological distress in the face of the patients’ life threat. To assist allo‐SCT recipients in navigating their life threat during treatment, it is desirable to establish avenues that provide adequate support.Trial Registration: German Registry of Clinical Trials: DRKS00027290
Response in Patients With Persistent Pelvic Pain to Motor Imagery Through Auditory or Visual Input—A Pilot Randomized Trial
Authors: Perez-Dominguez Borja , Arce-Elorza Alba , Rubio-Garcia Isabel , Diaz-Mohedo Esther 
Published: February 2025

Purpose: This study evaluates the response to a motor imagery intervention using visual or auditory inputs in patients with persistent pelvic pain. A secondary objective is to assess how patients’ mental visualization capacity influences intervention outcomes.Methods: Forty patients diagnosed with persistent pelvic pain were enrolled in a randomized trial with six motor imagery sessions over 2 weeks. Patients were assigned to interventions delivered through images or audio recordings. Pain intensity, attention to pain, and the ability to mentally visualize and perceive movements were assessed.Results: Participants receiving auditory stimulus–based interventions showed a nonsignificant reduction in pain intensity (from 7.1 points [SD: 1.9] to 6.1 points [SD: 2.4]; p = 0.091), while those in the visual input group experienced no change. Attention to pain improved in the visual group (from 30.2 points [SD: 6.2] to 27.6 points [SD: 6.8]; p = 0.194), whereas it remained stable in the auditory group. Importantly, the participants’ ability to mentally visualize and perceive movements did not significantly impact the outcomes.Conclusions: Auditory motor imagery appears to be a promising, less intrusive approach for managing persistent pelvic pain, with home‐based interventions showing potential where access to conventional care is limited. This study highlights the importance of personalized motor imagery approaches, demonstrating superior efficacy for auditory interventions compared to visual ones. Limitations include a brief intervention period and recruitment challenges, yet motor imagery remains a viable therapeutic option.Trial Registration: ClinicalTrials.gov identifier: NCT06343649