bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasopharyngeal carcinoma in India: End‐result analysis (1980–1984)
Authors: Koppikar S. B. , Advani S. H. , Gopal R. , Dinshaw K. A. , Pande S. C. , Nair C. N. , Tapan S. , Nadkarni K. S. , Borges A. , Desai P. B. 
Published: February 2007

AbstractOne hundred fifty patients with nasopharyngeal carcinoma were treated at the Tata Memorial Hospital from January 1980 to December 1984. Lymphoepithelioma was the most common histologie subtype. Advanced disease in stages III and IV was seen in 22.66% and 72% of the patients, respectively. Complete remission was obtained in 80 of 120 patients (66.66%) with radiation alone and in 19 of 30 patients (63.3%) who received preradiation chemotherapy and radiation. Age, sex, and histology did not influence the rate of complete remission. The N0‐1 nodal status group had a significantly better response of 81% and 36% survival, as compared with the N2_3 group with a 55% response and 20% survival. Only 30 of those who received radiation alone and 10 of those who received preradiation chemotherapy are disease‐free for a median period of 24 months. Twenty‐six relapses have occurred within a median period of 12 months. The 5‐year actuarial disease‐free survival is 13%. This indicates the need for an early diagnosis and combined aggressive treatment to improve survival.
Leiomyomas of the duodenum
Authors: Serraf A. , Klein E. , Schneebaum S. , Davidson B. , Herzic E. , Ben‐Ari G. 
Published: February 2007

AbstractLeiomyoma is a neoplasm of smooth muscle relatively common in the stomach, but very rare in the duodenal location. Symptoms are gastrointestinal bleeding or abdominal pain resembling peptic disease. Three cases of duodenal leiomyomas are described, and the importance of endoscopy is emphasized as a diagnostic tool. Surgical resection of the tumor is the recommended therapeutic procedure, and the difficulty in deciding at the pathological examination whether the leiomyoma is benign or malignant demands prompt follow‐up of patients after surgery.
Peripheral carcinoid tumours of the lung: A clinicopathological study
Authors: Abdi E. A. , Goel R. , Bishop S. , Bain C. O. 
Published: February 2007

AbstractPeripheral carcinoid tumours (PCT) of the lung are a distinct entity. These tumours arise from subsegmental or distal bronchioles, are usually well circumscribed and encapsulated, and contain varying amounts of spindle cells. Their histogenesis is from the Kultchitsky or neurosecretory type of cells. Of 52 patients with carcinoid tumours of the lung, 11 (21.1%) had PCT. The mean age was 60.2 years, 9 out of 11 patients were females, and about two‐thirds of tumours were in the left lung (8 out of 13). No patient developed carcinoid syndrome, but three patients had nonspecific respiratory symptoms. Bronchoscopy was not helpful in diagnosing any of these cases. Four patients required a wedge resection of the lung; the other six underwent lobectomy. One patient had tumours detected incidentally at autopsy. Mean tumour size was 2.39 cm (range 1.0‐5.0 cm); four tumours were 3.0 cm or larger in diameter. Three cases (27.3%) had regional lymph node metastases, but no systemic metastasis was discovered. Apart from the patient who was discovered to have carcinoid tumours at autopsy, all others are alive and disease‐free from 1 to 6 years after surgery.
Regression of locally recurrent squamous cell carcinoma of the skin following excision of a metastasis: With review of the literature
Authors: Roseman James M. 
Published: February 2007

AbstractThe spontaneous regression of a malignant tumor subsequent to surgical excision of a distant cancer is a fascinating observation. Although rare, this dynamic tumor/host relationship may offer important insight into mechanisms of immunologic surveillance. A better understanding of that interaction may help identify specific aberrations that predisposes to can cer development. Although the literature cites several histologically dis tinct cancers that demonstrate this phenomenon, a report of spontaneous regression of squamous cancer of the skin has not previously appeared. The case presented serves as the focal point for discussion of current concepts pertaining to this apparent host/tumor interaction.
New transurethral system for interstitial radiation of prostate cancer
Authors: Baumgartner George , Callahan Daniel , McKiel Charles F. , Zickgraf Eric , Forgione Hebe 
Published: February 2007

AbstractDirect endoscopic implantation of radioactive materials for carcinoma of the prostate without an open operation was accomplished by the use of modified existing transurethral instrumentation and techniques. The closed approach seems applicable particularly to the geriatric population, which is afflicted more commonly but is frequently not treated because of concurrent diseases or because the patient had transurethral resection of the prostate as a diagnostic procedure. Eleven patients were implanted using the transurethral route. Implantations were accomplished successfully with extremely low morbidity. Along with more conventional dosimetry studies, computer tomography was used to assess the placement of seeds. The direct visualization of the method suggests a potential for greater precision of seed placement as illustrated by computer tomography. In addition, this new instrumentation and method offers a low‐risk procedure for carcinoma of the prostate that can be performed on an outpatient basis for selected patients.
Prevention of hemorrhage by elastic suture material used for securing intravenous catheters within major branches of the portal vein
Authors: Sucarbaker Paul H. 
Published: February 2007

AbstractPortal venous infusion of chemotherapy may prove to be an important treatment effective in diminishing the incidence of hepatic metastases from colorectal cancer. To infuse drugs safely and reliably, we have cannulated major branches of the portal vein exposed during right or left colectomy. To prevent bleeding into the free peritoneal cavity upon catheter removal, the cannula is secured with elastic suture material. The technique has been used in 30 patients without complication.
Insulinoma: 31 years of tumor localization and excision
Authors: Zeng Xian‐Jue , Zhong Shou‐Xian , Zhu Yu , Fei Li‐Min , Wu Wei‐Jan , Cai Li‐Xing 
Published: February 2007

AbstractThis report is based on 31 years of experience with 116 cases of hyperin sulinism. Six cases had hypertrophy of the islets of Langerhans, 3 had widespead metastasis from malignant insulinomas, and 107 were benign adenoma cases. An immunoreactive insulin to glucose ratio of 0.3 of the peripheral venous blood before operation is of great value in diagnosing hyperinsulinism. Intraoperatively, immunoreactive insulin assay of the portal blood (IRI) is very valuable in determining if an insulinoma re mains. The dividing line is 100μU·ml−1. In localizing the tumor, “differ ential” PTPC is important before operation. During the operation, fine needle aspiration cytology may assist in ascertaining if the palpable tumor is an insulinoma. Multiple fine needle aspiration cytology examinations can sometimes reveal an insulinoma in an indurated pancreas. Portal vein blood IRI and blood sugar assays may serve to confirm if removal of the insulinoma is complete. Removal of the insulinoma controls hypoglycemia satisfactorily, but the brain damage incurred by prolonged hypoglycemia cannot be significantly altered. Removal of the tumor should be by enu cleation. and the raw surface of the pancreas should be drained not sutured.
Multiple functioning paraganglioma associated with polycythemia
Authors: Imai Tsuneo , Funahashi Hiroomi , Sato Yasuyuki , Nozaki Hideki , Asano Michio , Ueda Masakazu , Takagi Hiroshi 
Published: February 2007

AbstractMultiple retroperitoneal functioning paraganglioma complicated by polycythemia is reported in the case of a girl who, at the age of 13 years complained of headache, palpitation, and faintness preoperatively. In the retroperitoneal cavity, there were 21 paragangliomas larger than 1 cm in diameter. All were removed surgically in two sections, the first in 1979 and the second in 1983. Bilateral adrenals were macroscopically normal, and her symptoms disappeared. Now the recurrence of retroperitoneal paraganglioma is likely, although there have been no symptoms for 8 years, since the first operation. It is difficult to conclude that the tumors were benign or malignant in this case. Though complication of polycythemia had been diagnosed before the operation, the symptom continued even with the serum erythropoietin level kept in the normal range. Association of polycythemia with paraganglioma is extremely rare, and it is also rare to find more than 10 paragangliomas. Only a limited number of reports have been made on each case in the literature.
Prognostic significance of mRNA‐encoding estrogen receptor and epithelial growth factor receptor in breast carcinoma progression into lymph nodes: 1. Estrogen receptor encoding mRNA
Authors: Hakim Anwar A. 
Published: February 2007

AbstractThe main objective of this study was to differentiate between lymph nodes infiltrated by estrogen receptor‐positive (ER+) and estrogen receptor‐negative (ER−) breast carcinoma. Lymph nodes were obtained from 40 postmenopausal cancer patients, 10 from each disease stage. Six patients from each group had estrogen receptor‐positive (BCaER+) and four estrogen receptor‐negative (BCaER−) tumors. Both tumor‐containing (T) and uninvolved (N) lymph nodes from the same patient were examined by the following parameters: magnitude of lymph node nucleic acid hybridization with cDNA probes from breast cancer MCF‐7ER+ and MCF‐7ER− cells; and binding capacity of 3H‐estradiol, 125I‐EGF, and 125I‐PDGF binding and protein kinase C activities of the lymph nodes. Concomitant with the appearance of transformed cells, several events occur: Tumor cells induce stimulation of mononuclear cells and macrophages and evoke T‐ and B‐cell proliferation, leading to the synthesis of tumor cell membrane‐associated antibodies. In estrogen receptor‐positive (ER+) breast carcinoma, estrogens and host hormonal modulatory mechanisms stimulate production and release of epithelial growth (EGF) and platelet‐derived growth factors (PDGF). These factors are characterized by protein kinase C activities. There is infiltration of tumor cells into the lymph node and infiltration of leukocytes into the tumor site. In the lymph node, tumor progression depends on tumor cell proliferation rate and metastatic agressiveness. The experiments described in this study document the changes that occur in lymph nodes, with differences between nodes infiltrated with BCaER+ and BCaER− breast carcinomas. Hybridization of 32P‐cDNA from MCF‐7ER+ cells with cellular RNA from BCaER+ involved (T) lymph nodes is greater than with cellular RNA from uninvolved (N) lymph nodes. The magnitude of hybridization correlated (P < 0.005) with the disease stage.
Tissue carcinoembryonic antigen levels in benign and malignant diseases of the breast
Authors: Horowitz J. D. , Au F. C. , Tang C. K. , Stein B. , Campana T. J. 
Published: February 2007

AbstractThe peroxidase‐antiperoxidase histochemical method of staining for tissue carcinoembryonic antigen (CEA) was performed on 20 samples of malignant breast tissue, 20 samples of fibroadenomatous breast tissue, and 15 samples of breast tissue that variably contained minimal fibrosis (N = 7), ductal ectasia (N = 5), and sclerosing adenosis (N = 3; the fibrocystic changes of the breast). The intensity of staining was described to be either negative, weak, intermediate, or strong and was assigned a point value of 1, 2, 3, or 4, respectively. The following weighted average values of tissue CEA were obtained: carcinoma, 3.35 ± 0.88; fibroadenomas, 2.85 ± 0.67; fibrocystic changes, 2.13 ± 0.52. Carcinomatous tissue is likely (55%) to display intense tissue staining, whereas fibrocystic disease (0%) or fibroadenoma (15%) are unlikely to exhibit such a reaction. The tissue CEA content between carcinoma and fibrocystic changes (P < 0.01), carcinoma and fibroadenoma (P < 0.01), and fibroadenoma and fibrocystic changes (P < 0.05) are statistically significant.
Effect of splenectomy upon the growth of B16‐F10 melanoma and its relation to the interferon system
Authors: Stoll Howard L. , Chadha Kailash C. 
Published: February 2007

AbstractThe influence of splenectomy upon the growth of B16‐F10 malignant melanoma and changes in interferon‐synthesizing ability in mice were studied. Surgical stress alone temporarily diminished the ability of mice to respond to interferon induction by poly rIrC. Two weeks following the surgery, mock‐splenectomized mice fully regained their interferon synthesis ability. However, this was not true in the case of splenectomized mice. They remained refractory to interferon induction. The removal of the spleen had no obvious effect on the rate of pulmonary metastasis in mice injected with B16‐F10 malignant melanoma in relation to the mock‐splenectomized or control mice. Mice that were splenectomized and inoculated with B16‐F10 melanoma also remained refractory to interferon induction.
Vaccinia virus‐infected C‐C36 colon tumor cell lysates stimulate cellular responses in vitro and protect syngeneic balb/c mice from tumor cell challenge
Authors: Iwaki Hiroyuki , Barnavon Yoav , Bash Jerry A. , Wallack Marc K. 
Published: February 2007

AbstractVaccinia virus (VV) was used to infect and lyse the Balb/c colon tumor line C‐C36 to prepare oncolysate (VCO) with augmented immunogenicity. Mice treated with VCO and challenged with C‐C36 were significantly protected against tumor growth as compared to untreated controls (P < 0.001) and mice treated with CO (P < 0.01). Moreover, protection induced by VCO was specific when growth inhibition of C‐C36 was compared to that of meth‐A (P = 0.027). Splenocytes from mice stimulated with VCO in vitro showed greater proliferation than splenocytes stimulated with CO alone or VV alone, suggesting induction of a unique VCO component. Additional evidence for a specific response was suggested by the observation that splenocytes stimulated with VCO in vitro demonstrated augmented cytolysis of C‐C36 but did not show cytolytic activity against unrelated target cells. However, augmented cytolysis of the natural killer (NK)‐sensitive YAC‐1 by VCO‐stimulated splenocytes was also observed. These results suggest that in vivo resistance to tumor challenge induced by VCO treatment may result from stimulation of both specific and nonspecific effector cells.
Accuracy of cytologic diagnosis and cytotyping of sputum in primary lung cancer: Analysis of 161 cases
Authors: Liang Xiao Man 
Published: February 2007

AbstractSputum cytologic examination is still an important method for diagnosing lung cancer, and it is simple to perform. The present report is an analysis of 161 cases of primary lung cancer proved by thoracotomy. A detection rate of 73.3% in sputum and 84.5% in combination with other cytologic methods have been obtained. Cytotyping accuracy as compared with histologic classification in 105 cases was 79.0%. The importance of examining more than three sputum samples from a patient with suspected lung cancer is stressed.
Immunohistochemical analysis of mesocolic lymph node cells in human colorectal cancer
Authors: Miura Seiji , Tsuchiya Haruo , Shikata Jun‐Ichi , Hosoda Yōichirō , Shiina Eiichi 
Published: February 2007

AbstractLocalization of lymphocyte subsets and macrophages in the mesocolic lymph node of the colorectal cancer and their distribution among the paracolic, intermediate, and main nodes were studied quantitatively by means of immunohistochemical staining with monoclonal antibodies. In all of the three lymph node groups, in the paracortex, helper/inducer T cells were more numerous than suppressor/ cytotoxic T cells. The number of whole T cells in the paracortex diminished with increasing proximity to the primary tumor. In the three lymph node groups, no significant difference was found regarding the ratio of the cell number among suppressor/ cytotoxic T cells, natural killer cells, and macrophages. Lymphocytes in the paracortex of lymph node had a positive correlation to lymphocytes in the peritumoral stroma and intratumoral fields. These data neither suggest the presence of a powerful immunological reaction in the mesocolic lymph node nor support the concept of conservation of uninvolved regional lymph nodes in the surgery of the colorectal cancer.
Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region
Authors: Ishikawa Osamu , Ohhigashi Hiroaki , Teshima Teruki , Chatani Masashi , Inoue Toshihiko , Tanaka Sachiko , Kitamura Tsugio , Wada Akira , Sasaki Yo , Imaoka Shingi , Iwanaga Takeshi 
Published: February 2007

AbstractA retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X‐ray was given, all 18 tumors decreased from 3.3±0.8 cm to 2.0±0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic resection, without operative death. Histologically, in 13 of these 16 cases, the population of severely degenerative cancer cells (SDCC) was more than 1/3 of all cancer cells, and SDCCs were likely to locate at the periphery (advancing point of carcinoma). These histological patterns were considered as favorable to improve the operative curability. However, in the remaining three cases, the SDCC population was less than 1/3. In addition, nonaffected (i.e., viable) cancer cells were detected at the periphery, and this is an extremely adverse condition for subsequent surgery. Chronic pancreatitis in the noncancerous area was present in these three cases, but not in the 13 cases. Therefore, the most significant factor that predicts the radioresistance especially at the periphery of the carcinoma was considered to be coexisting chronic pancreatitis.
Angiomatoid malignant fibrous histiocytoma: Flow cytometric DNA analysis of six cases
Authors: El‐Naggar Adel K. , Ro Jae Y. , Ayala Alberto G. , Hinchey William W. , Abdul‐Karim Fadi W. , Batsakis John G. 
Published: February 2007

AbstractUsing flow cytometry, we examined the DNA content of six angiomatoid “malignant” fibrous histiocytomas (AMFH), seven nonangiomatoid MFH, and seven myxoid variants of MFH. All six AMFHs were diploid. All nonangiomatoid MFHs and six of seven of the myxoid variant were aneuploid. The clinical course, histological appearance, and ploidy pattern of AMFH are distinctly different from other MFH variants. These differences strongly suggest that AMFH is at the benign end of the clinicobiologic spectrum manifested by “malignant” fibrous histiocytomas.
Megaprostheses in the treatment of primary malignant and metastatic tumors in the hip region
Authors: Veth R. P. H. , Nielsen H. K. L. , Oldhoff J. , Koops H. Schraffordt , Mehta D. , Oosterhuis J. W. , Kamps W. A. , Göeken L. N. H. 
Published: February 2007

AbstractTwenty patients with malignant bone tumors of the hip region were treated surgically by resection and reconstruction with an endoprosthesis. Histologic types included five primary bone tumors and 15 metastatic lesions. At review four primary bone tumor patients are still alive without evidence of disease. The length of the observation period varied from 26 to 104 months. Eleven patients with metastatic bone disease died. The average postsurgical survival time was 23 months. All patients were able to walk with or without a cane. Failure of an endoprosthesis occurred in one case. According to the Enneking Evaluation System 11 patients had a good and 9 a fair result.
Non‐Hodgkin's lymphoma in Northern Israel: A study of 481 patients with emphasis on ethnic‐related patterns
Authors: Cohen Yoram , Kuten Abraham , Ben‐Shahar Menahem , Haim Nissim , Epelbaum Ron , Ben‐Arie Yehudith 
Published: February 2007

AbstractDuring the period between 1970‐1984, 481 patients with previously untreated non‐Hodgkin's lymphoma were referred to the Northern Israel Oncology Center, Haifa. There were 264 (54.9%) Ashkenazi Jews, 123 (25.6%) non‐Ashkenazi Jews, and 86 (17.9%) Arabs. The mean age at diagnosis was 60 ± 15 years for Ashkenazi Jews, 45 ± 22 years for non‐Ashkenazi Jews, and 36 ± 22 years for Arabs. Ashkenazi Jews had a higher rate of nodular lymphoma compared to non‐Ashkenazi Jews and Arabs. Extranodal lymphoma occurred more frequently in non‐Ashkenazi Jews and Arabs. Lymphoma of the small intestine was more common in Arabs than in Ashkenazi and non‐Ashkenazi Jews. Despite these differences in the pattern of disease, 5 year actuarial survival figures for the various ethnic groups were similar.
Bilateral radical neck dissection: Report of results in 55 patients
Authors: Ahn Chae , Sindelar William F. 
Published: February 2007

AbstractBetween 1952 and 1982, 55 patients underwent bilateral radical neck dissections at the National Cancer Institute. Of these, 17 patients had simultaneous (one‐stage) bilateral dissections and 38 had nonsimulta‐neous (two‐stage) dissections. In 37 patients both internal jugular veins were removed, while one vein was preserved in 18 patients. The operative mortality was 11.8% (2/17 patients) for simultaneous bilateral neck dissections and 2.6% (1/38 patients) for nonsimultaneous staged dissections. The overall operative mortality was 5.4%. Of the 18 patients in whom one jugular vein was preserved, six patients (33%) had postoperative facial edema and swelling, while of the 37 patients in which neither jugular vein was saved, 20 patients (54%) developed significant postoperative facial edema. The overall 2‐year recurrence rate was 50%. The overall survival rates were 55% at 3 years and 39% at 5 years.
Management of malignant obstructive jaundice
Authors: Rosen Joseph , Young Shun C. , Berman Joel , Magill Thomas 
Published: February 2007

AbstractThis study compares the efficacy of percutaneous transhepatic drainage (PTD) versus operative biliary decompression for patients with malignant obstructive jaundice. The utilization of preoperative PTD as a surgical adjuvant is also examined. The records of 90 patients with obstructed jaundice from two large community hospitals were reviewed. In the group of patients undergoing curative resections, no advantage was noted for the patients who received preoperative PTD. The patients receiving only surgery left the hospital 8 days sooner. For the patients undergoing palliative treatment, the group receiving only the surgery had the lowest morbidity and mortality and the longest survival rates. The patients receiving only PTD had the shortest hospital stay, but also had many complications, the highest mortality rate, and the shortest survival rate. The group receiving preoperative PTD followed by surgical decompression had more complications and stayed in the hospital longer, with no change in postoperative mortality.
Invasion and metastasis following orthotopic transplantation of human pancreatic cancer in the nude mouse
Authors: Vezeridis Michael P. , Doremus Craig M. , Tibbetts Lance M. , Tzanakakis George , Jackson Benjamin T. 
Published: February 2007

AbstractA good experimental model for metastasis of human pancreatic cancer would be a valuable tool for the study of this process, which contributes significantly to morbidity and mortality. Models of experimental metastasis using injection of tumor cells into the portal or systemic circulation bypass some important steps of the metastatic process. We describe invasion and metastasis following orthotopic transplantation of human pancreatic carcinoma into nude mice. Tumor pieces were used as xenografts in this study, and metastases were observed in the regional lymph nodes, liver, lungs, and distant lymph nodes of the animals. Peritoneal implants and ascites were not observed in this study. Orthotopic transplantation of human pancreatic cancer in the nude mouse appears to be a promising model of spontaneous metastasis relevant to clinical reality.