bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Kecerdasan Emosional terhadap Perencanaan Karier Siswa Kelas XI di MAN 1 Kota Bengkulu
Authors: Muhammad Nikman Naser  , Refsi Anisa Fa’ati  
Published: February 2025

Setiap siswa memiliki kemampuan yang berbeda satu dengan yang lainnya dimana dapat dilihat dari minat, bakat serta kecerdasan. Perencanaan karier merupakan langkah awal yang dilakukan seseorang dalam mencapai tujuan kariernya. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kecerdasan emosional terhadap perencanaan karier siswa kelas XI di MAN 1 Kota Bengkulu. Penelitian ini menggunakan jenis penelitian kuantitatif dengan pendekatan korelasi. Metode pengumpulan data yang digunakan ialah dengan melakukan penyebaran angket (kuesioner). Pemilihan sampel menggunakan teknik probability sampling dengan jenis proportionate stratified random sampling, berdasarkan teknik tersebut dengan jumlah populasi 388 siswa maka sampel pada penelitian ini berjumlah 198 siswa. Dari hasil penelitian didapatkan bahwa terdapat hubungan yang signifikan antara kecerdasan emosional dengan perencanaan karier siswa. Hasil uji tersebut dapat dilihat bahwa nilai koefisien determinan R square sebesar 0,023 < 0,05 yang berarti adanya kontribusi hubungan kecerdasan emosional dengan variabel perencanaan karier. Implikasi penelitian ini sebagai need assesment siswa dalam memahami perkembangan karier dan guru BK dapat mendesain suatu pendekatan bimbingan dan konseling karier yang efektif.
Coronary artery bypass surgery and sexual function
Authors: Yuksel Mehmet Bilgehan , Gecit Ilhan , Karakose Ayhan , Pirincci Necip , Gunes Mustafa , Aydin Cemalettin , Kaba Mehmet 
Published: February 2025

Objectives:To evaluate the influences of coronary artery by-pass surgery(CABS) on sexual function(SF) and the comorbidities on the impact of CABS on SF.
Methods:The data of 112 patients who underwent CABS and interviewed by full form of IIEF questionnaire before and 6 months after CABS were retrospectively evaluated. We specifically analyzed and compared the preoperative and postoperative(PAP) IIEF questionnaire(IQ) results to determine the influences of CABS on SF. Furthermore, we separately analyzed the same PAP data in diabetic, hypertensive and both diabetic and hypertensive subgroups and compared the data in each group to find possible influences of the comorbidities on the impact of CABS on SF.
Results:The mean age was 61,7±9,1. The number of patients without erectile dysfunction(ED) increased from 3(%2.6) to 7(%6.2), with severe and moderate ED decreased from 85(%75.9) to 33(%29.4), with mild ED increased from 24(%21.4) to 72(%64.2) after CABS, which revealed the severity of ED declined in overall and ED completely improved in some patients after CABS. The total IIEF, erectile function(EF), intercourse satisfaction, orgasmic function and sexual desire scores significantly increased after CABS(P=0,000). Although OS(Overall Satisfaction) had an increase, no statistically significant alteration was found(P= 0,04). The SF most improved in both diabetic and hypertensive group, it was least affected in diabetic group.
Conclusions:CABS had positive impacts on EF and almost all domains of SF. While the lonely presence of diabetes did not significantly affect the impact of CABS on SF, the SF most improved in both diabetic and hypertensive cases after CABS.
Retrospective analysis of deep sedation in pediatric population for endoscopic procedures: adverse events and outcomes
Authors: Isik Berrin , Sivgin Volkan , Arslan Mustafa , Kartal Seyfi , Unal Yusuf , Akcabay Mehmet 
Published: February 2025

Background: Upper gastrointestinal endoscopy (E) and colonoscopy (C) procedures are not well tolerated in pediatric population. General anesthesia or sedation applied during gastroendoscopic procedures. This study is done to review our sedation practice and to evaluate the clinical effectiveness and side effects of an anaesthesiologist administered deep sedation for gastroendoscopic procedures outside the operating room.
Methods: After Institutional Review Board Approval, the charts of all children who underwent endoscopic procedure at the outpatient endoscopy suite under sedation, (Jan 2011- December 2011) were reviewed retrospectively.
Results: Deep sedation was used in 301 procedures, which 255 were endoscopic and 23 were colonoscopic procedures. Twenty-three children had both procedures performed in one session. Demographic details: Age [year, mean]: 10,1±5,1, Gender (M/F): 152/149, Body weight [kg, (mean±SD )]: 35.7±18.7. Severe bradycardia with oxygen desaturation was recorded in two patients. All procedures were carried out successfully. Emergence delirium was seen in only one patient who was the substance user. No significant side effect derived from intervention was observed during the procedures, except one case (perforation of the colon).
Conclusion: Deep sedation applied by anesthesiologist found to be adequately safe and appropriate for children during gastroendoscopic procedures.
Relationship Between Premature ventricular complexes and Neutrophil–Lymphocyte Ratio in asymptomatic healty young men
Authors: Kibrisli Erkan , Iscen Sinan , Yilmaz Ahmet , Ozenc Salim , Parlak Adem , Tok Duran 
Published: February 2025

Background: Premature ventricular complexes (PVC) are a relatively common electrocardiographic abnormality presenting in individuals without overt cardiovascular disease. There is no clear mortality benefit from VPB suppression in asymptomatic patients. In addition, It has been showed that evidence for structural heart disease consistent with non-ischemic scarring possibly due to inflammation in patients with premature ventricular beats . This situation suggests that the mechanisms by which VPBs can be also generated with include clinical and subclinical inflammation. The neutrophil–lymphocyte ratio (NLR) is an easy, cheap, noninvasive, and universally available laboratory marker used to evaluate clinical and subclinical systemic inflammation.We investigated the NLR in asymptomatic healty young men with PVC(structural heart disease excluded with cardiac magnetic resonance imaging) compared with controls.
Methods: The study group consisted of 21 asymptomatic(or atypical complaint) healty young men with PVC ( mean age 22.7 ± 2.0 years.
Results:There were no significant differences between the 2 groups with respect to age, gender, body mass index, smoking, as well as glucose, creatinine, total cholesterol, triglyceride, LDL-C, HDL-C, hemoglobin levels, white blood cell count, and red cell distribution width. The NLR was significantly higher among the men with PVC than that of the control group (2.7 ±0.7 vs 1.5 ± 0.4, respectively; P < .001).
Conclusions: We found that the NLR is significantly elevated in asymptomatic healty young men with PVC compared with control participants. The increased NLR values might indicate subclinical and clinical inflammation in asymptomatic healty young men with PVC ,and we must consider that there
One year experience of emergency service in patients with penetrating head trauma due to firearm
Authors: Karabag Hamza , Kilic Mustafa , Ethemoglu Kadri Burak , Buyukaslan Hasan 
Published: February 2025

Objective: We aimed to share the features of 45 patients with firearm injuries related head traumas and our experiences in their treatments.
Methods: Our cases consisted of 36 males 45 patients in total between the ages of 18-65, who were brought to the emergency service of our hospital due to firearm injuries. For this retrospective study, it was accessed to the patient data from the archival records of our hospital. The demographical data of the patients like age and gender, and the records such as type of injury, injured area in head, diagnosis, treatment and follow ups were reviewed.
Results: There were sinus injury related epidural haemorrhages in 8 of patients who underwent urgent surgical intervention (17.8%). In 18 of the patients (39.95%) who underwent surgery had supratentorial injuries and 7 (15.55%) had infratentorial injuries. All these 25 patients (55.50%) who underwent surgery had multiple intracranial injuries (compression fracture + subdural haemorrhage + contusion + pneumocephalus + SAH + brain edema). Four of these 6 patients with multiple injuries had abdominal injuries. Two patients had haemopneumothorax. There were vertebra and extremity injuries in 2 patients with abdominal injuries.
Conclusions: Brain injuries occurring with the firearm head injuries are seen as multiple injuries and their rate of mortality is quite higher.
Successful treatment of severe aplastic anemia with eltrombopag: a case report
Authors: Eser Ali , Eser Funda Pepedil , Toptas Tayfur , Bozkurt Suheyla , Kombak Erdem , Atagunduz Isik Kaygusuz , Kara Osman , Tuglular Ayse Tulin Firatli 
Published: February 2025

Introduction: Aplastic anemia is a clinical syndrome characterized by peripheral pancytopenia and deficiency of hematopoietic precursors in the bone marrow. Allogeneic hematopoietic stem cell transplantation (AHSCT) should be considered as first line treatment for young patients with an available donor. However,alternative therapy options are scant in patients who are not candidates for transplantation. Here, we report the efficacy of eltrombopag in a case of severe aplastic anemia.
Case Presentation: Twenty-two years old female patient was admitted to the Marmara University Hospital because of severe aplastic anemia. There was not an available HLA-matched sibling donor and immunosuppressive treatment with horse-derived ATG (40 mg per day for 5 days) and cyclosporine (5 mg/kg per day) was started. At the sixth month of therapy she was still in need of transfusion. Eltrombopag was prescribed at a dose of 50 mg and the dose was increased up to 150 mg per day in 2 months. Successful response was noted within 2 weeks of 150 mg dosage and this response was sustained at the 4th month following discontinuation of drug.
Conclusions: Eltrombopag provides good and permanent clinical response in refractory severe aplastic anemia.
Investigation of GREMLIN 1, COL15A1 immunoreactivity and the relationship between microvessel density and GREMLIN 1 in papillary renal cell carcinoma and chromophobe renal cell carcinoma
Authors: Kara Sevgul , Karakok Metin 
Published: February 2025

Objective: The current study aimed to investigate expressions of Gremlin 1 (GREM1) (a bone morphogenetic protein antagonist and a proangiogenic factor) and COL15A1 (Collagen type XV alpha-1, encodes the proteoglycans located in various human tissues and particularly in the basement membrane) immunohistochemically in papillary renal cell carcinoma (PRCC) and chromophobe renal cell carcinoma (CRCC) in order to assess the relationship between these markers and said tumors and also explore associations of GREM1 with angiogenesis, tumor necrosis and tumor diameter by looking at the microvascular density (MVD) through the expression of COL15A1 in vascular endothelium.
Material and Method: GREM1 and COL15A1 expressions were investigated in 20 PRCC and 39 CRCC patients. Cytoplasmic staining with GREM1 and COL15A1 was examined. Microvascular structures stained with COL15A1 were examined in order to evaluate angiogenic profile.
Results: In CRCC, GREM1 staining was statistically significant in tumor tissues compared to intact tissues (p=0.006). The relationship between MVD and GREM1 staining was statistically significant in PRCC (p=0.007). Cytoplasmic staining with COL15A1 observed in PRCC was statistically significant (p=0.005).
Conclusion: Positive GREM1 staining observed in both tumor groups and much higher expression of this marker particularly in the tubular epithelium of the neighboring normal tissue supports our argument that this gene might be a tumor suppressor gene.
Aqueous garlic extract protects against sepsis induced toxicity in pulmonary and ileal tissues
Authors: Ozkan Sevil , Akbay Tugba Tunalı , Sakarcan Selin , Gunay Emre , Sener Goksel 
Published: February 2025

Objective: Based on the potent antioxidant effects of aqueous garlic extract (AGE), the present study was designed to characterize the potential of AGE to modify blood coagulation parameters as well as and pulmonary and ileal injury in septic rats. Sepsis was induced using the caecal ligation and perforation (CLP) method.
Methods: Twenty-four hours after sepsisinduction, rats were decapitated and trunk blood was collected for the measurement of platelet counts, fibrinogen, prothrombin time, activated partial thromboplastin time and D-dimer levels. Then, pulmonary and ileal tissue samples were immediately obtained and stored at – 70oC for malondialdehyde (MDA), glutathione, myeloperoxidase (MPO) and superoxide dismutase (SOD) activity assays.
Results: Sepsis was associated with a decrease in platelet count and fibrinogen and an increase in APTT and INR. It also caused a significant decrease in GSH levels and SOD activity in both pulmonary and ileal tissue samples. On the other hand, AGE treatment in rats with CLP caused significantly augmented the level of these antioxidants. As a result of CLP induction increased MPO activity and MDA levels and decreased thromboplastic activity were reversed with AGE treatment.
Conclusion: AGE treatment, through its antioxidant effects, protects against oxidative pulmonary and ileal injury and normalizes the impaired coagulation in sepsis.
Hepatitis a seropositivity and characteristics among healthcare workers in a training and research hospital in Istanbul
Authors: Sahin Ahmet Melih , Tekin Ayse , Basmaci Cem , Kes Nuray Uzun , Sonmez Emine 
Published: February 2025

Objective: In this study, we investigated the relationship between the socioeconomic status, living conditions, life span, working life timeand the seropositivity of HEPATITIS A Virus (HAV) infection among our hospital staff members.
Material and Methods: Anti-HAV IgG testing of randomly selected 167 healthcare workers were examined in 2012-2013. All participants answered on a questionnaire consisting questions on transmission routes and socioeconomic status.
Results: Overall HAV seropositivity was found to be %43.1 among healthcare workers with a mean age of 33.4for subjects with positive results and 27.4 years with negative results. Observed risk factors for seropositivity were the life span, professional working life time, life time in Istanbul, history of living in rural areas and frequent toilet usage outside of the house (p < 0.05). The factors that are inversely associated with seropositivity were educational level of parents, being born in Aegean-Mediterranean region, bottled water share in drinking water consumption and being a physician (p < 0.05).
Conclusion: HAV infections contniue to be a serious problem.Vaccination must be considered for seronegative healthcare workers and the public.
The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection
Authors: Geyik Sirma , Bozkurt Hakan , Neyal Munife , Yigiter Remzi , Kuzudisli Samiye , Kul Seval 
Published: February 2025

Objective: In the present study, we aimed to determine the predictive value of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of Guillain-Barré Syndrome (GBS).
Material and Methods: This retrospective study enrolled 94 GBS patients and a control group of 101 healthy subjects.
Results: GBS patients had significantly higher NLR, C- Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) values at presentation than the healthy control group (p < 0.001, p < 0.001, p < 0.001, respectively). Patients unresponsive to IVIg therapy had significantly higher NLR values at the time of admission in comparison to responsive patients (p=0.001). NLR was significantly and positively correlated with the disease severity, CRP and ESR. A receiver operating characteristic (ROC) analysis of the ability of NLR to predict GBS showed a cutoff value of 3.5 (sensitivity 62.8%, specificity 90.1%). The cutoff value was 11 for CRP (sensitivity 52.7%, specificity 86%) and 12.3 for ESR (sensitivity 51.3%, specificity 82%). Exclusion of patients with signs of infection at presentation gave a NLR value of 3.2, which had a sensitivity of 61.6% and a specificity of 89.8% for predicting GBS.
Conclusion: Whereas ESR and CRP lost their significance in predicting GBS. Unlike ESR and CRP, NLR might be a promising marker in GBS regardless of infection.
Seasonal effects of the monoamine oxidase inhibitor deprenyl but not the tricyclic antidepressant imipramine in rats bred for helplessness
Authors: Schulz Daniela 
Published: February 2025

Objective: Seasonal variations in monoaminergic function may underlie seasonal affective disorder, a subtype of major depression. Here, we examined whether antidepressant drugs which regulate monoaminergic function exhibit seasonal effects in an animal model of depression, congenital helplessness.
Material and Method: Rats selectively bred for helplessness were required to press a lever to turn off a foot-shock before and after chronic treatment with the tricyclic antidepressant imipramine (10 mg/kg) or the monoamine oxidase inhibitor deprenyl (10 mg/kg). Control rats received saline. Different groups of rats were tested in summer-fall and spring over the course of two years.
Results: Congenitally helpless (cH) rats that were treated with imipramine pressed the lever more often than controls in fall and in spring, indicative of antidepressant effects regardless of season. By contrast, cH rats treated with deprenyl pressed the lever more often in summer-fall than in spring, suggestive of seasonal drug effects on helplessness behavior. Deprenyl significantly attenuated the lever-pressing deficit in both seasons when compared to saline controls. Moreover, cH rats treated with deprenyl but not imipramine increased the number of lever presses over trials, indicative of negative reinforcement learning.
Conclusion: The present data are the first to show seasonal variations in antidepressant drug effects that are possibly linked to changes in dopamine neurotransmission. The data support the view that we must take seasonality into account when evaluating the efficacy of antidepressant compounds.
Prediction by maternal risk factors and prenatal care of neonatal intensive care of neonatal intensive care admission in a University Hospital, Turkey, a case control study
Authors: Avci Sezer , Col Meltem , Yavuz Yasemin , Yilmaz Elif Akkas 
Published: February 2025

Objective: Determine socioeconomic characteristics, prenatal care and maternal risk factors and to reveal the impact on newborn, in mothers who gave birth.
Materials and Methods: A case-control study comparing the mothers whose babies admitted and whose babies not admitted to neonatal intensive care unit of a University Hospital. 200 women as a case and 200 women as a control chosen among total 958 women. A survey form filled to determine socioeconomic and prenatal care features and the risk factors. The APNCU index is used for adequacy of prenatal care. Chi square test, Fisher’s exact test and multiple logistic regression analysis are used for statistical evaluation.
Results: As to prenatal care 94.3 % of the mothers received adequate amount and 95.2 % adequate content. The location of residence (OR:2.72), husband education (OR:1.97), spontaneous abortion in second trimester or preterm birth history (OR:4.27), multiple pregnancy (OR:5.25), bigger or smaller uterine size (OR:26.58), early uterine contraction (OR:2.21), and problems during delivery (OR:2.53) variables were related to be in neonatal intensive care unit.
Conclusion: Factors related to being in intensive care found in this study should be understood and interpreted in all of the steps of health services, and interventions should be executed when necessary.
Secondary primary malignancy presence and related factors in chronic lymphocytic leukemia
Authors: Ekinci Omer , Dogan Ali , Demircioglu Sinan , Turgut Ergin , Demir Cengiz 
Published: February 2025

Objective: The secondary primary malignancy frequencies have seen increased in chronic lymphocytic leukemia (CLL) regardless of therapy. The aim of this study was to investigate the frequency of secondary primary malignancy in patients followed with the diagnosis of chronic lymphocytic leukemia.
Materials and Methods: The 183 patients with diagnosed of CLL were enrolled into this study. The data of the patients were evaluated retrospectively. Patients diagnosed with CLL were categorized according to age, gender and presence or absence of additional malignancy. Patients with CLL and concomitant malignancy were compared with other patients.
Results: Fifty four patients (29.5%) were female and 129 (70.5%) were male. Secondary primary malignancy was detected in 9 (%4,9) patients. CD5 positivity was found in all of the patients with malignancy and in 91% of whole patients. 5.4% of males and 3.7% of females had solid organ tumors with CLL. Although the proportion of solid tumors was higher in males, this difference was not statistically significant (p = 0.847). The mean age of cases with secondary malignancy was statistically significantly higher than that without secondary malignancy (p <0.05).
Conclusion: In our study, all of the patients with the second primary malignancy were CD5 positive. BCL2 proto-oncogene levels were found increased in CD5-positive CLL cells, not in normal B cells those were positive for CD5. In vitro studies showed that, B-CLL cells with higher BCL2 levels survive is longer than cells with lower BCL2 levels. Presence of the secondary malignancy except CLL may be related with BCL2 increment as well as CD5 positivity. We need more comprehensive studies to determine the relationship between the presence of BCL2, CD5 positivity and secondary malignancies.
Effects of melatonin and agomelatine on doxorubicin induced anxiety and depression-like behaviors in rats
Authors: Aygun Hatice , Gul Serdar Savas 
Published: February 2025

Objective: Doxorubicin (DOX) is a chemotherapeutic agent used to treat several cancer types; however, it exhibits severe side effects in the nervous system which DOX treatment evoked neurobehavioral alterations such as anxiety and depressive-like behavior. We investigated the use of melatonin and agomelatine to prevent neurobehavioral alterations caused by DOX.
Material and Methods: Forty-nine Wistar albino rats were randomly divided into 7 groups, namely control (CON, n=7), doxorubicin (DOX, n=7), melatonin (MEL, n=7), agomelatine (AGO, n=7), melatonin + doxorubicin (MEL + DOX, n=7), agomelatine + doxorubicin (AGO + DOX, n=7) melatonin + agomelatine + doxorubicin (MEL + AGO + DOX, n=7) groups. Doxorubicin (18 mg/kg) was injected intraperitoneally (i.p) on the 5th, 6th, 7th day of the study. Animals were treated with melatonin (40 mg/kg/i.p), agomelatine (40 mg/kg/i.p), melatonin (40 mg/kg/i.p) + agomelatine (40 mg/kg/i.p), for 7 days and then doxorubicin (18 mg/kg/i.p) was injected on the 5th, 6th, 7th day. On the 8th day of the experiment, all animal evaluated open field test (OFT) and forced swim test (FST) respectively.
Results: The only DOX-treated rats exhibited the reduced exploration, grooming, and locomotor activity in the open field test and increased immobility time, reduced swimming time. Our data showed that the rats treated with DOX exhibited anxiety and depressive-like behavior. Melatonin and agomelatine treatment reduced all the parameters of DOX-induced anxiety and depressive-like behavior in rats.
Conclusions: Melatonin and agomelatine have a protective effect of against DOX-induced neurobehavioral alterations in rats.