bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant therapy as a paradigm to develop systemic cancer therapy
Authors: Sonpavde Guru 
Published: December 2008

AbstractNeoadjuvant systemic therapy preceding definitive surgical resection permits the in vivo assessment of tumor response and induces pathologic downstaging in several malignancies. Since pathologic complete response (pCR) and biologic activity can be determined rapidly, the signal of efficacy of a systemic regimen is evident with a relatively small number of patients before long‐term follow‐up. Additionally, emerging data suggest that modulation of pharmacodynamic biomarkers after brief neoadjuvant therapy may correlate with long‐term clinical outcomes. Early evidence for in vivo resistance and elucidation of mechanisms of resistance may assist with selection of rational combinations of agents as subsequent therapy to improve outcomes. Evidence of biologic anti‐tumor activity in target‐enriched subsets can be determined with a small number of patients in proof of principal pilot trials. Biologic activity against molecular targets and downstream anti‐proliferative and pro‐apoptotic activity may help with the selection of the lowest effective dose, which may lead to efficacious and safe therapy. Therefore, this paradigm has the potential to enable the efficient use of resources and accelerate the pace of systemic therapy development. It may also be possible to determine molecular and biologic characteristics that predict for sensitivity. Drug Dev Res 69:388–397, 2008. © 2008 Wiley‐Liss, Inc.
Recent advances in the development of novel anti‐cancer drugs targeting cancer stem/progenitor cells
Authors: Mimeault Murielle , Batra Surinder K. 
Published: December 2008

AbstractRecent advances in basic and clinical oncology have led to the identification and characterization of several deregulated gene products involved in cancer progression to invasive, metastatic, and recurrent disease stages. Particularly, an emerging body of experimental evidence has revealed that an accumulation of genetic and/or epigenetic alterations can lead to the malignant transformation of tissue‐resident adult stem/progenitor cells into leukemic or tumorigenic cancer stem/progenitor cells. These immature cancer cells endowed with a self‐renewal capacity and aberrant differentiation potential that can drive leukemia and tumor development and metastases being responsible for treatment resistance and disease relapse. Therefore, the molecular targeting of deregulated signaling elements that may contribute to the uncontrolled growth, survival, invasion, and resistance of these cancer‐initiating cells to current clinical cancer therapies is of great therapeutic interest. Potential anti‐cancer drug targets include telomerase, anti‐apoptotic factors, DNA repair, and detoxifying enzymes and ATP‐binding cassette multidrug transporters as well as distinct oncogenic cascades, including hedgehog, EGFR, Wnt/β‐catenin, Notch, and/or polycomb group (PcG) protein chromatin‐silencing pathways. The combined targeting of these deregulated gene products should reverse multidrug resistance and eliminate the cancer‐initiating cells and their differentiated progenies. Hence, these novel targeting approaches could be used to improve the efficacy of current therapeutic treatments against the highly aggressive, metastatic, recurrent and lethal cancers. Drug Dev Res 69:415–430, 2008. © 2008 Wiley‐Liss, Inc.
Newly developed effective anti‐cancer drugs targeting multiple myeloma
Authors: Sze Daniel Man‐Yuen , Hou Jian , Zhou Lily 
Published: December 2008

AbstractMultiple myeloma (MM) is considered predominantly a cancer of the elderly with a median patient age of 60–65 years at diagnosis and 88% of patients being over 55 years. The disease has remained incurable with a mean survival period of about 3 years for the last 30 years. In the last decade, three useful cancer drugs, namely, thalidomide, lenalidomide, and bortezomib, have been approved by the FDA to append the armamentarium of MM chemotherapy other than the standard combination of melphalan and prednisone that have been used since the 1960 s. Many clinical trials supported by in vitro laboratory investigations have been conducted to understand both the efficacy and mechanisms of the action of these cancer drugs. This brief review aims to provide an overview of new cancer drugs targeting MM and discuss the development of novel strategies for targeting this incurable disease. Drug Dev Res 69:451–459, 2008. © 2008 Wiley‐Liss, Inc.
Respiratory sinus arrhythmia and cognitive functioning in children
Authors: Staton Lori , El‐Sheikh Mona , Buckhalt Joseph A. 
Published: December 2008

AbstractWe examined associations between children's cognitive performance and both basal respiratory sinus arrhythmia (RSA) and RSA regulation to a reaction time task. Cognitive performance was examined in the lab via standardized tests of cognitive functioning (Woodcock–Johnson III) and a reaction time task. Results suggest that a higher level of basal RSA is predictive of better performance on WJ III scales examining fluid intelligence (e.g., working memory, cognitive efficiency). RSA reactivity was not significantly related to cognitive performance. Results build on and extend the literature by demonstrating that, in typically developing elementary school age children, RSA is related to well‐standardized measures of cognitive performance even after controlling for potential confounds. © 2008 Wiley Periodicals, Inc. Dev Psychobiol 51: 249–258, 2009
Gene targeted ablation of high molecular weight fibroblast growth factor‐2
Authors: Azhar Mohamad , Yin Moying , Zhou Ming , Li Hongqi , Mustafa Marwan , Nusayr Eyad , Keenan Jack B. , Chen Hwudaurw , Pawlosky Sharon , Gard Connie , Grisham Christina , Sanford L. Philip , Doetschman Tom 
Published: December 2008

AbstractFibroblast growth factor‐2 (FGF2) is produced as high molecular weight isoforms (HMW) and a low molecular weight isoform (LMW) by means of alternative usage of translation start sites in a single Fgf2 mRNA. Although the physiological function of FGF2 and FGF2 LMW has been investigated in myocardial capillarogenesis during normal cardiac growth, the role of FGF2 HMW has not been determined. Here, we report the generation of FGF2 HMW‐deficient mice in which FGF2 HMW isoforms are ablated by the Tag‐and‐Exchange gene targeting technique. These mice are normal and fertile with normal fecundity, and have a normal life span. Histological, immunohistochemical, and morphometric analyses indicate normal myocardial architecture, blood vessel, and cardiac capillary density in young adult FGF2 HMW‐deficient mice. These mice along with the FGF2‐ and FGF2 LMW‐deficient mice that we have generated previously will be very useful for elucidating the differential functions of FGF2 isoforms in pathophysiology of cardiovascular diseases. Developmental Dynamics 238:351–357, 2009. © 2008 Wiley‐Liss, Inc.
Regimented and lifestyle restraint in binge eating disorder
Authors: White Marney A. , Masheb Robin M. , Grilo Carlos M. 
Published: December 2008

AbstractObjective:This study tested the psychometric properties of two commonly used measures of dietary restraint, the Three Factor Eating Questionnaire and the Eating Disorder Examination Questionnaire.Method:Restraint data from 512 overweight/obese participants with binge eating disorder (BED) were subjected to exploratory and confirmatory factor analyses.Results:Factor analyses of the restraint variables indicated a two‐factor solution, interpreted as “Regimented” and “Lifestyle” restraint. Stepwise regression analyses revealed that Regimented restraint was more predictive of eating pathology, whereas Lifestyle restraint appeared to be protective of eating problems. Neither type of restraint was related to binge eating. Cluster analysis of the restraint dimensions yielded three distinct subgroups of patients who differed significantly on several important eating‐ and weight‐related features.Discussion:Future research is needed to test the significance of these restraint constructs over time in both the development of obesity and binge eating problems as well as their treatment. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Family structure, body mass index, and eating behavior
Authors: Hasenboehler Kathrin , Munsch Simone , Meyer Andrea H. , Kappler Christoph , Vögele Claus 
Published: December 2008

AbstractObjective:To explore associations between family structure, children's body mass index (BMI), and eating behaviors of children and their mothers.Method:Fifty‐seven mothers and their children took part in an experimental study. BMI of children was measured. Mothers were asked to provide self‐report data on sociodemographic background, mental health, and eating behaviors about themselves and their children. Parent‐child‐dyads represented their family structure using the Family System Test.Results:We found negative associations in typical family situations between family hierarchy and children's BMI, mothers' emotional eating and mothers' restrained eating. Family cohesion and restrained eating of the children were also negatively correlated. We obtained positive associations in typical and conflict family situations between family cohesion and external eating of the children.Discussion:We found indications that family structure is associated with overweight and with eating behavior in children and their mothers. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Energy metabolism and body composition in long‐term recovery from anorexia nervosa
Authors: Dellava Jocilyn E. , Policastro Peggy , Hoffman Daniel J. 
Published: December 2008

AbstractObjective:The aim of this study was to determine if energy metabolism and body composition differ between women recovered from anorexia nervosa for 2 or more years (RAN) and control (C) women.Method:Using a cross‐sectional design, 16 RAN and 18 C women were studied. Respiratory quotient (RQ) and resting energy expenditure (REE) were measured using indirect calorimetry and body composition using dual energy X‐ray absorptiometry.Results:The REE between RAN and C women was not significantly different, even when adjusted for body composition. However, RAN women had a higher rate of fat oxidation (p = .015), controlling for diet and body composition. There were no significant differences between the groups for body composition, percent body fat, or percent truncal fat mass.Discussion:Although RAN women have a higher rate of fat oxidation, there were no significant differences in REE or body composition when compared with C women. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Zolpidem induced nocturnal sleep‐related eating disorder (NSRED) in a male patient
Authors: Dang Amit , Garg Gaurav , Rataboli Padmanabh V. 
Published: December 2008

AbstractNocturnal Sleep‐Related Eating Disorder (NSRED) is a well‐documented sleeping disorder where the person is reported to experience bizarre eating behavior during sleep. Although various causes are implicated in this disorder, role of drugs cannot be ruled out. Here we narrate an interesting rare case report of a drug‐induced new onset NSRED, where a 45‐year‐old man on zolipdem performed an unexpected and bizarre eating behavior during somnambulistic state, type of which has not been reported earlier in the literature. The case falls under even rarer category as such behavior in sleep is reported mainly in woman. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Gender difference in the prevalence of eating disorder symptoms
Authors: Striegel‐Moore Ruth H. , Rosselli Francine , Perrin Nancy , DeBar Lynn , Wilson G. Terence , May Alexis , Kraemer Helena C. 
Published: December 2008

AbstractObjective:This study examined gender differences in prevalence of eating disorder symptoms including body image concerns (body checking or avoidance), binge eating, and inappropriate compensatory behaviors.Method:A random sample of members (ages 18–35 years) of a health maintenance organization was recruited to complete a survey by mail or on‐line. Items were drawn from the Patient Health Questionnaire and the Body Shape Questionnaire.Results:Among the 3,714 women and 1,808 men who responded, men were more likely to report overeating, whereas women were more likely to endorse loss of control while eating. Although statistically significant gender differences were observed, with women significantly more likely than men to report body checking and avoidance, binge eating, fasting, and vomiting, effect sizes (“Number Needed to Treat”) were small to moderate.Discussion:Few studies of eating disorders include men, yet our findings suggest that a substantial minority of men also report eating disorder symptoms. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Longitudinal examination of maternal psychological control and adolescents' self‐competence as predictors of bulimic symptoms among boys and girls
Authors: Salafia Elizabeth H. Blodgett , Gondoli Dawn M. , Corning Alexandra F. , Bucchianeri Michaela M. , Godinez Nicole M. 
Published: December 2008

AbstractObjective:Because bulimia nervosa is a problem among adolescents, it remains essential to examine its precursors. The specific etiologic chain investigated in this study is such that maternal psychological control first leads to adolescents' lowered self‐competence, which in turn predicts bulimic symptoms.Method:Self‐report data were collected from 58 boys and 73 girls during sixth, seventh, and eighth grades. Participants reported on maternal psychological control, self‐competence, and bulimic symptoms.Results:Using structural equation modeling, we tested our hypothesized longitudinal indirect effects model separately for boys and girls. Results indeed indicated that high maternal psychological control in sixth grade led to lowered adolescents' self‐competence in seventh grade, which in turn predicted increased bulimic symptoms in eighth grade for both boys and girls.Discussion:This study uncovers one particular process wherein a psychologically controlling parenting style affects adolescents' development of bulimic symptoms, a finding that may be useful to researchers and clinicians. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Rate of inpatient weight restoration predicts outcome in anorexia nervosa
Authors: Lund Brian C. , Hernandez Elsa R. , Yates William R. , Mitchell Jeff R. , McKee Patrick A. , Johnson Craig L. 
Published: December 2008

AbstractObjective:To examine weight restoration parameters during inpatient treatment as predictors of outcome in anorexia nervosa (AN).Method:Adolescent and adult females admitted for inpatient eating disorder treatment were recruited for an ongoing longitudinal study. This analysis examined several weight restoration parameters as predictors of clinical deterioration after discharge among participants with AN.Results:Rate of weight gain was the only restoration parameter that predicted year 1 outcome. Clinical deterioration occurred significantly less often among participants who gained ≥0.8 kg/week (12/41, 29%) than those below this threshold (20/38, 53%) (χ2 = 4.37, df = 1, p = .037) and remained significant after adjustment for potential confounders.Discussion:Weight gain rate during inpatient treatment for AN was a significant predictor of short‐term clinical outcome after discharge. It is unclear whether weight gain rate exerts a causal effect or is rather a marker for readiness to tolerate weight restoration and engage in the recovery process. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Anorexic self‐control and bulimic self‐hate: Differential outcome prediction from initial self‐image
Authors: Birgegård Andreas , Björck Caroline , Norring Claes , Sohlberg Staffan , Clinton David 
Published: December 2008

AbstractObjective:The study investigated initial self‐image (structural analysis of social behavior) and its relation to 36‐month outcome, among patients with anorexia nervosa and bulimia nervosa. Hypotheses were that degree of different aspects of self‐image would predict outcome in the groups.Method:Participants were 52 patients with anorexia and 91 with bulimia from a longitudinal naturalistic database, and outcome measures included eating disorder and psychiatric symptoms and a general outcome index. Stepwise regression was used to investigate which self‐image variables were related to outcome, and multiple regression contrasted the groups directly on each obtained predictor.Results:Consistent with hypotheses, in bulimia degree of self‐hate/self‐love moderately predicted outcome, whereas self‐control–related variables powerfully predicted outcome in anorexia.Discussion:It is important to focus on self‐image in the treatment of both diagnostic groups, but especially in anorexia nervosa, where control‐submission interactions between patient and therapist should be handled with care. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Regioselective Monoiodination of Carba‐closo‐dodecaborates: M[7‐I‐12‐X‐closo‐CB11H10] (M = Cs+, [Et4N]+; X = F, Cl, Br, OH)
Authors: Finze Maik 
Published: December 2008

AbstractSelective monoiodination of a series of carba‐closo‐dodecaborates with a halogen atom or a hydroxy substituent bonded to the antipodal boron atom resulted in salts of the novel anions [7‐I‐12‐X‐closo‐CB11H10]– [X = F (1), Cl (2), Br (3), OH (4)]. These anions were isolated as [Et4N]+ salts and converted into the Cs+ salts. The novel compounds were studied by multi NMR spectroscopy, mass spectrometry (MALDI), and elemental analysis. The solid‐state structure of Cs[7‐I‐12‐HO‐closo‐CB11H10]·(CH3)2CO was determined by single‐crystal X‐ray diffraction. The assignment of the NMR spectroscopic data and the discussion of structural properties was supported by the results of the DFT calculations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Cathodic Stripping Voltammetry of Uracil. Experimental and Theoretical Study Under Conditions of Square‐Wave Voltammetry
Authors: Mirčeski Valentin , Skrzypek Sławomira , Lovrić Milivoj 
Published: December 2008

AbstractThe electrode mechanism of uracil at a hanging mercury drop electrode (HMDE) is studied under cathodic stripping square‐wave voltammetric mode owing to the cathodic dissolution of a sparingly soluble compound formed between the electrode material and uracil. The experimental results can be partly explained in the light of the recent theory for cathodic stripping processes of insoluble salts under conditions of square‐wave voltammetry. It is established that the electrode reaction is complicated by attractive interactions between the deposited species of the insoluble compound. To elucidate the electrode mechanism completely a novel theoretical model is developed considering adsorption of the reacting analyte and lateral interactions between species of the insoluble compound. With the help of numerical simulations the effect of interactions is studied in detail, emphasizing the properties of the response that can be used as diagnostic criteria for recognition of the type of interaction forces. Theoretically predicted voltammetric properties agree well with the experimental results enabling clarification of the complex electrode mechanism of uracil at HMDE.
Interactions of Dissolved dsDNA with Intercalating Drug by Anodic Voltammetry and Spectroscopy. Influence of pH
Authors: Nowicka Anna M. , Zabost Ewelina , Klim Barbara , Mazerska Zofia , Stojek Zbigniew 
Published: December 2008

AbstractThe interactions of C‐1305 (5‐dimethylaminopropylamino‐8‐hydroxy‐6H‐v‐triazolo[4,5,1‐de]acridin‐6‐one) with DNA were studied using differential pulse voltammetry and UV‐vis spectroscopy. C‐1305 interacts with dsDNA in two ways: by intercalation and by binding to the minor‐groove. For the intercalation at physiological pH (7.4) the values of the binding constant, K1, and the binding‐site size, n1, equal 3.36×105 M−1 and 2.5, respectively. For the weak interactions the K2 and n2 parameters equal 0.18×105 M−1 and 4. In the presence of excess NaCl the weak interactions do not vanish, therefore they are assigned to the minor groove binding. Substantial and complex is the influence of pH.
Recent progress in the use of ionic polymers as pseudostationary phases for electrokinetic chromatography
Authors: Palmer Christopher P. 
Published: December 2008

AbstractThis review is an account of the development, utilization, and characterization of polymeric pseudostationary phases (PSPs) for EKC since the previous review in this series in 2007. Improvements in performance by means of new polymeric phases and modifications to previously reported materials are described. The use of EKC and spectroscopic studies to characterize the interactions between polymeric PSPs and analytes is discussed. The application of polymeric PSPs for techniques or approaches to which they provide particular advantages is reviewed. Chief among these is the application of polymeric PSPs for the combination of EKC with MS detection.
Recent advances in the methodology, optimisation and application of MEEKC
Authors: Ryan Richie , Donegan Sheila , Power Joe , McEvoy Eamon , Altria Kevin 
Published: December 2008

AbstractMEEKC is an electrodriven separation technique. Oil‐in‐water microemulsions (MEs) and to a lesser extent water‐in‐oil MEs have been used in MEEKC as BGEs to achieve separation of a diverse range of solutes. The more common (oil‐in‐water) MEs are composed of nanometre‐sized droplets of oil suspended in an aqueous buffer. Interfacial tension between the oil and aqueous phase is reduced close to zero by the presence of a surfactant and a co‐surfactant. MEEKC is capable of providing fast and efficient separations for a wide range of acidic, basic and neutral, water‐soluble and ‐insoluble compounds. This review details the advances in MEEKC‐based separations from the period 2006 to 2008. Areas covered include online sample concentration, chiral separation, suppressed electroosmosis MEEKC, MEEKC‐MS, and the use of MEEKC in predicting migration behaviour and solute characteristics. A fundamental introduction to MEEKC, along with the presentation and discussion of recent applications is also included.
Non‐aqueous capillary electrophoresis 2005–2008
Authors: Geiser Laurent , Veuthey Jean‐Luc 
Published: December 2008

AbstractThis review article presents recent developments and applications of non‐aqueous capillary electrophoresis (NACE): The text covers the period from the previous review (L. Geiser, J. L. Veuthey, Electrophoresis 2007, 28, 45–57) to summer 2008. We focus primarily on the analysis of pharmaceutical drugs by non‐aqueous solvents in CZE within different matrices including phytochemical plant extracts and biological fluids. We also extend our discussion to other application fields (e.g. food material and environmental samples) and to chiral separations by NACE. This review focuses on practical aspects of NACE, illustrating which organic solvents and electrolytes are best suited for NACE analyses and their compatibilities with different detection techniques, including UV, LIF and MS. The review emphasizes the interests of using non‐aqueous solvents in place of water for the analysis by CZE, and as an alternative to MEKC.