bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new synthesis of 6‐(alkyl)amino‐3‐aryl(alkyl)‐1,2,4,5‐tetrazines
Authors: Counotte‐Potman Anda , Van Der Plas Henk C. 
Published: March 2009

AbstractA new method for the preparation of 6‐(alkyl)amino‐3‐aryl(alkyl)‐1,2,4,5‐tetrazines is described. Dissolving 3‐aryl(alkyl)‐1,2,4,5‐tetrazines in liquid ammonia or a primary aliphatic amine at −35° to −40°, followed by addition of potassium permanganate gives the title compounds in reasonable to excellent yields.
Etude de l'oxydation de tétrahydroisoquinoléinols‐4 diméthoxylés en 6,7 ou 7,8, et sur la réactivité du carbonyle de la tétrahydroisoquinolone‐4 diméthoxylée en 6,7
Authors: Lesèche Bernard , Gilbert Jacques , Viel Claude 
Published: March 2009

AbstractPréparation des tétrahydroisoquinoléinols‐4 mentionnés ci‐dessus, et étude de l'oxydation de ceux‐ci au moyen de divers réactifs: oxydations chromiques, par les bromamides, le diméthyl‐sulfoxyde, la réaction d'Oppenauer. Seule cette dernière a conduit aux tétrahydroisoquinolones‐4 cherchées. A l'exception du bromoacétamide et de l'Oppenauer, tous les autres réactifs fournissent une trioxo‐1,3,4 tétrahydroisoquinoléine. Le comportement de la tétrahydroisoquinolone‐4 diméthoxylée en 6,7, vis‐à‐vis de certains réactifs spécifiques de la fonction carbonyle est étudié.
Chemistry of the phenoxathiins and isosterically related heterocycles. XIV. Total assignment of the 13C‐Nmr spectrum of pyrrolo[3,2,1‐kl]phenothiazine
Authors: Gampe Robert T. , Martin Gary E. , Pinto Angelo C. , Hollins Richard A. 
Published: March 2009

AbstractTotal assignment of the 13C‐nmr spectrum of the novel tetracyclic phenothiazine, pyrrolo[3,2,1‐kl]phenothiazine is described. Assignments were determined from model systems, 1H‐13C spin‐coupling behavior in conjunction with selective excitation techniques and spin‐lattice (T1) relaxation measurements. The anisotropic reorientation of this ring system via a principal axis passing through the center of the molecule, which provides a qualitative basis for signal discrimination, is also discussed.
1‐(1‐aryl‐3‐ethylthiocarbamido)‐4‐arylaminothiocarbonyl)‐ piperazines as possible anticonvulsants
Authors: Singh Shiva P. , Parmar Surendra S. 
Published: March 2009

AbstractSeveral 1‐(1‐aryl‐3‐ethylthiocarbamido)‐4‐(arylaminothiocarbonyl)piperazines were synthesized as possible anticonvulsants. These 1,4‐disubstituted piperazines were characterized by their sharp melting points and elemental and spectral analyses.
Ortho effects in 3‐methyl‐5‐(o‐r‐styryl)‐4‐aminoisoxazoles on electron impact. III
Authors: Martínez R. , Cortés E. 
Published: March 2009

AbstractElectron impact mass spectra of eight of the title compounds are discussed. Based on our data a mechanism for the formation of the m/e 91 ion is proposed. Fragmentation pathways have been confirmed by measurement of the metastable peaks.
Benzo[h]cinnolin
Authors: Bluhm Thorsten 
Published: March 2009

AbstractThe synthesis of benzo[h]cinnolin (3) is reported. Its spectroscopic properties (uv, luminescence, pmr, ms) are similar to the other diazaphenanthrenes containing a diazine ring. The lowering of the basicity of 3 compared with a monoazaphenanthrene like other diaza‐aromatic compounds appears to be due to an electrostatic field effect and not to an inductive effect.
Amidrazones. 6. Synthesis of 1,2,4‐thiadiazoles by thermolysis of N3‐thiocarbamoylamidrazone ylides
Authors: Smith Richard F. , Feltz Timothy P. 
Published: March 2009

AbstractReaction of N3‐unsubstituted amidrazone ylides (1a and 1b) with alkyl or aryl isothiocyanates gives N3‐thiocarbamoylamidrazone ylides (2). Thermolysis of 2 gives 3‐alkyl(or aryl)‐5‐alkyl(or aryl)amino‐1,2,4‐thiadiazoles (3a‐i).
Selenium‐sulfur analogs. 4. Synthesis and characterization of (±)‐β‐(2‐amino‐1,3‐selenazol‐4‐yl)alanine
Authors: Hanson Robert N. , Davis Michael A. 
Published: March 2009

AbstractThe novel amino acid (±)‐β‐(2‐amino‐1,3‐selenazol‐4‐yl)alanine 4a was prepared from selenourea and 1,3‐dichloropropan‐2‐one via a four‐step synthetic sequence. Nuclear magnetic resonance analysis indicated a downfield chemical shift of δ 0.29 to 0.30 and δ 0.57 for the C5‐proton of the protonated 2‐amino‐and 2‐acetamido‐1,3‐selenazoles respectively compared with the analogous thiazoles. The infrared spectra of the selenazole and corresponding thiazole compounds were virtually identical.
The photochemical reactions of 5H‐benzo[a]phenoxazin‐5‐one with alkylthiols and thiophenol
Authors: Ueno Yoshio , Takeuchi Yutaka , Koshitani Jinya , Yoshida Takatoshi 
Published: March 2009

Abstract6‐Alkylthio‐ and 6‐phenylthio‐5H‐benzo[a]phenoxazin‐5‐ones have been synthesized by the photochemical reaction of 5H‐benzo[a]phenoxazin‐5‐one with alkylthiols and thiophenol.
Tetrahydro‐2‐thioxo‐2H‐1,3,5‐thiadiazin‐4‐ones and their derivatives representing a novel heterocyclic ring system
Authors: Bélai Iván , Sohár PÁL , Maekawa Kazuyuki , Párkányi László , Matolcsy GyÖRgy 
Published: March 2009

AbstractThe cyclization reaction between N‐substituted dithiocarbamates (1) and N‐substituted N‐chloromethylcarbamoyl chlorides (2) gives 3,5‐disubstituted tetrahydro‐2‐thioxo‐2H‐1,3,5‐thiadiazin‐4‐ones (3). In order to decide among the theoretically possible structures 3‐5, the compounds 6a,b, containing a thioxo group instead of an oxo group as in 3a,b, as well as the S‐oxide derivative of 3a was also established by X‐ray structure determination.
Synthesis and characterization of some bifunctional 2b:2:1 cryptands
Authors: Gansow Otto A. , Kausar A. Rashid , Triplett Kelly B. 
Published: March 2009

AbstractMethods for the synthesis of aromatic substituted diaza‐polyoxamacrobicyclic compounds (benzocryptands) are described. New synthetic routes to cryptand precursors are developed and improvements in eryptand synthesis discussed and employed to prepare some bifunctional cryptands.
Amidrazones. VII. Formation of s‐triazines by thermolysis of N1‐benzyl‐substituted amidrazone ylides
Authors: Smith Richard F. , Soelch Richard R. , Feltz Timothy P. , Martinelli Michael J. , Geer Susan M. 
Published: March 2009

AbstractThe preparation of ylides of the general structure magnified image is described. Thermolysis of 14a (R = CH3, R' = H, Ar = C6H5) gave dimethylamine and 2,4‐dimethyl‐6‐phenyl‐s‐triazine. Thermolysis of ylides 14b (R = C6H5; R' = CH3, Ar = C6H5) and 14c (R = C6H5, R' = CH3, Ar = p‐tolyl) gave dimethylamine, ArCH = NCH3 and 1‐methyl‐2‐Ar‐4,6‐diphenyl‐1,2‐dihydro‐s‐triazines (19a,b). Triazines 19a and 19b were also prepared by condensation of N‐methylbenzamidine with benzaldehyde and p‐tolualdehyde, respectively. Thermolysis of 14d(R = C6H5, R1 = CH2C6H5,Ar = C6H5) gave 1‐benzyl‐2,4,6‐triphenyl‐1,2‐dihydro‐s‐triazine (19c) and N‐benzylidenebenzylamine. Mechanistic aspects of these reactions are discussed.
New synthesis of chalcogenolactones. 1H,3H‐benzo[c]selenophen‐1‐one, 1H,3H‐benzo[c]tellurophen‐1‐one and the related 3,4‐dihydro‐1H‐2‐benzoselenin‐1‐one and 3,4‐dihydro‐1H‐2‐benzotellurin‐1‐one
Authors: Loth‐Compère M. , Luxen A. , Thibaut Ph. , Christiaens L. , Renson M. , Guillaume M. 
Published: March 2009

AbstractThe synthesis of three new basic heterocyclic systems namely, 1H,3H‐benzo[c]tellurophen‐1‐one (2‐tellurophthalide), 3,4‐dihydro‐1H‐2‐benzoselenin‐1‐one (3,4‐dihydro‐2‐isoselenocoumarin) and 3,4‐dihydro‐1H‐2‐benzotellurin‐1‐one (3,4‐dihydro‐2‐isotellurocoumarin), is reported through the cyclisation of o‐(bromoalkyl)benzoyl chlorides.
Reactions of some benzofuran derivatives with amides, nitriles and hydrazines
Authors: Abd el Rahman A. H. , Kandeel E. M. 
Published: March 2009

AbstractWhen 6‐acetoacetyl‐5‐methoxy‐ (1b) and 5‐acetoacetyl‐6‐methoxy‐2,3‐diphenylbenzofuran (2b) were treated with cyanoacetamide, the corresponding pyridinecarbonitriles were obtained. Compounds 1b and 2b reacted with ethyl cyanoacetate in the presence of ammonium acetate to give the benzofuranyl‐pyrone derivatives. This reaction, when carried out in presence of diethylamine, led to the formation of furochromones. Hydrazine hydrate, phenylhydrazine and semicarbazide hydrochloride reacted with 1b and 2b with the formation of the corresponding pyrazoles. The corresponding isoxazole derivatives were formed by the reaction of 1b and 2b with hydroxylamine hydrochloride.
Reactions of hydrazidoyl chlorides with sodium N,N‐dialkyldithiocarbamates
Authors: Kaugars Girts , Rizzo Victor L. 
Published: March 2009

AbstractThe reaction of N‐arylbenzhydrazidoyl chlorides (1) with sodium N,N‐dialkyldithiocarbamates yields the hydrazone derivatives 2, which react further to form 4 unless the reaction sites are sterically crowded.
The Dimer of Δ1(8)‐Dehydropyrrolizidine and Its Reduction
Authors: Sumoto Kunihiro , Fujii Skinichiro , Yamashita Osamu , Somehara Takao , Miyano Seiji 
Published: March 2009

AbstractThe structure and reductions of the dimer of Δ11(8)‐dehydropyrrolizidine are described.
Reductive dimerization of 1,3,4,6‐tetramethyl‐2‐phenylpyrimidinium bistetrafluoborate
Authors: Douglass James E. , Bumgarner David L. 
Published: March 2009

AbstractThe diquaternary salt, 1,3,4,6‐tetramethyl‐2‐phenylpyrimidinium bistetrafluoborate (3) was found to undergo reductive dimerization in the presence of zinc to afford the diquaternary salt 6.
Action du dicétène sur la benzoylcyanamide: La benzoylamino‐2 méthyl‐6 oxazine‐1,3 one‐4
Authors: Perronnet Jacques , Girault Pierre , Taliani Laurent 
Published: March 2009

AbstractLe dicétène opposé à la benzoylcyanamide donne lieu à une cycloaddition 1,4 avec le groupement nitrile de cette dernière. Le produit résultant est une oxazine‐1,3 one‐4 qui se prěte à diverses réactions d'ouverture ou de réarrangement, initiées par la grande réactivité de son sommet 2.
Synthesis of 3‐Coumaryl Phenyl Sulfones or Sulfoxides
Authors: Merchant J. R. , Shah P. J. 
Published: March 2009

AbstractAn unambiguous synthesis of a number of 3‐coumaryl phenyl sulfones or sulfoxides have been described which were obtained by the oxidation of the corresponding sulfides with hydrogen peroxide. The sulfides were prepared by the Perkin‐Oglialore reaction of o‐hydroxyaldehyde with the sodium salt of different S‐phenyl thioacetic acids. The sulfones did not exhibit any appreciable antitubercuious activity in the preliminary screening tests.
New Synthesis of (±)‐5‐hydroxymarmesin, biogenetic precursor of the skin photosensitizing agent bergapten (5‐MOP)
Authors: Rodighiero P. , Manzini P. , Pastorini G. , Guiotto A. 
Published: March 2009

AbstractA convenient synthesis is described of (±)‐5‐hydroxymarmesin, 4‐hydroxy‐2‐(1‐hydroxy‐1‐methylethyl)‐2,3‐dihydro‐7H‐furo[3,2‐g][1]benzopyran‐7‐one, a physiological intermediate in the biogenetic pathway of 5‐O‐alkylfurocoumarins. The synthesis was achieved by a regiospecific 6‐C isoprenylation of 5,7‐diacetoxy‐coumarin; the 6‐C isoprenylated derivative is then submitted to an oxidative cyclization obtaining mainly the title compound together with its angular isomer.
Reinvestigation of the stevens rearrangement of 1‐benzyl‐1,3,4‐trimethyl‐1,2,5,6‐tetrahydropyridinium salts. II. Synthesis of 2‐aryl‐3‐isopropenyl‐1,3‐dimethylpyrrolidines
Authors: Bosch Joan , Rubiralta Mario 
Published: March 2009

Abstractcis‐2‐Aryl‐3‐isopropenyl‐1,3‐dimethylpyrrolidines Ha and IIb have been synthesized by an unambiguous way, thus confirming the structure of the methylene derivatives obtained as by‐products in the Stevens rearrangement of 1‐benzyl‐1,3,4‐trimethyl‐1,2,5,6‐tetrahydropyridinium salts Ia and Ib. The synthesis is based on the acid‐induced intramolecular cyclization between an iminium salt and the α‐position of a ketal group. Thus, condensation between amino ketal XXI, prepared via Gabriel synthesis from 5‐chloro‐3‐methyl‐2‐pentanone, and the appropriate aldehyde afforded imines XXI. Their treatment with dry hydrogen chloride followed by acid hydrolysis and methylation gave 3‐acetylpyrrolidines IV, which were transformed into the isopropenyl derivatives II by reaction with methyl‐lithium and further dehydration.
Reactions of o‐aminonitriles with isocyanates. 2. A facile synthesis of imidazo[1,2‐c]quinazoline‐2,5‐(3H,6H)dione
Authors: Papadopoulos Eleftherios Paul 
Published: March 2009

AbstractAnthranilonitrile reacts with ethyl isocyanatoacetate to form 2‐(3‐ethoxycarbonylmethylureido)benzonitrile (3b) which, upon heating, or treatment with a base, undergoes a double cyclization to yield imidazo[1,2‐c]‐quinazoline‐2,5‐(3H,6H)dione (5) in excellent yield. In the presence of acid, 3b is converted into 1,4‐dihydro‐2,4‐dioxo‐3‐(2H)quinazolineacetic acid (11), or its ethyl ester (10). The action of concentrated sulfuric acid converts the adduct 13 of anthranilic acid and ethyl isocyanatoacetate into 2‐ethoxycarbonyl‐methylamino‐4H‐3,1 ‐benzoxazin‐4‐one (14).
Ethynylogues du nicotinamide et de l'isoniazide
Authors: Babin Pierre , Dunoguès Jacques , Duboudin Françoise 
Published: March 2009

AbstractDeux voies d'éthynylation ont été mises en oeuvre en série nicotinique et isonicotinique, ce qui a permis de préparer pour la première fois les éthynylogues du nicotinamide et de l'isoniazide: le (pyridyl‐3)propynyl amide 1 et le (pyridyl‐4)propynyl hydrazide 2, respectivement. Ces synthèses utilisent comme intermédiaire les chlorures de nicotinoyle et d'isonicotinoyle dont nous avons proposé une synthèse de mise en oeuvre beaucoup plus simple et rapide que les méthodes déjà existantes.
The preparation of the benzo[4,5]cyclohepta[1,2‐b]pyrazine and benzo[4,5]cyclohepta[1,2‐b]quinoxaline systems
Authors: Eberle Marcel K. , Kahle Gerard G. 
Published: March 2009

AbstractBenzo[4,5]cyclohepta[1,2‐b]quinoxaIine 2, benzo[4,5]cyclohepta[1,2‐b]pyrazine 3a and benzo[4,5]cyclohepta[1,2‐b]quinoxaline 4 were prepared from 4,5‐benzotropolone and 1,2‐phenylenediamine, ethylenediamine and 1,2‐diaminocyclohexane, respectively. Compound 3a was methylated to 3b.
Mass spectral fragmentation pattern of 4,4′‐bipyridines. Part II. 4,4′‐oxybispyridine and 4,4′‐thiobispyridine
Authors: Rockley Jean E. , Summers Lindsay A. 
Published: March 2009

AbstractThe mass spectra of 4,4′‐oxybispyridine and 4,4′‐thiobispyridine are reported. In the former the base peak is due to the molecular ion and the fragmentation routes involve loss of H, CO, HCN, C2H2N and CsHO from the molecular ion as well as rupture of the central bonds. In the latter the base peak is also due to the molecular ion and the fragmentation routes involve loss of H, CS, S, HCN and C2HS as well as central bond rupture.
Investigation in tetronic acid ketoxime derivatives. Structure and beckmann rearrangement. Synthesis of 3‐acetamidotetronic acids
Authors: Gelin Suzanne 
Published: March 2009

AbstractThe structure and tautomeric equilibria of 3‐(1‐hydroxyiminoethylidene)tetronic acids have been investigated by 1H and 13C nmr spectroscopy. These oximes are convertible into 3‐acetamidotetronic acids.
The synthesis of “stretched‐out” analogs of lumazine, 6,7‐dimethyllumazine and 2‐amino‐5,6,7,8‐tetrahydro‐6,7‐dimethyl‐4‐pteridinone
Authors: Schneller Stewart W. , Christ William J. 
Published: March 2009

AbstractThe synthesis of pyrazino[2,3‐g]quinazolin‐2,4‐(1H,3H)dione (4) and its 7,8‐dimethyl derivative (5), as linear benzo‐separated lumazines, is reported. Also described is the preparation of 2‐amino‐6,7,8,9‐tetrahydro‐7,8‐dimethylpyrazino[2,3‐g]quinazolin‐4‐one (6), as a linear benzo‐separated analog of a synthetic cofactor for phenylalanine hydroxylase. All of the syntheses began with ethyl 2,4,5‐triaminobenzoate (8) and proceeded through the appropriate derivatives of ethyl 6‐aminoquinoxaline‐7‐carboxylate (9, 10, and 11) which were subsequently ring closed to 4, 5, and 6.
Condensation of β‐cyclocitral with benzaldehyde
Authors: Frank Arlen W. 
Published: March 2009

Abstractβ‐Cyclocitral 1b condenses with benzaldehyde in the presence of base catalysts giving the 2‐benzopyrans 4, 5 and 6, and in the presence of acid catalysts giving exclusively the aldehyde 7. The cyclocitrals 1a and 1b are both isomerized by strong base anion exchange resins, but their aldehyde‐protected derivatives 2 and 3 are not. Some tests used to characterize the aldehydes and their condensation products are described.
Pyrazoles. XVIII. Synthesis of a novel tripyrazolyl by two consecutive cine substitution reactions
Authors: Berbee Robertas P. M. , Habraken Clarisse L. 
Published: March 2009

AbstractPreparation of the C‐N coupled tripyrazolyl VII, by two consecutive cine substitution reactions starting from 1,4‐dinitropyrazole and using pyrazole as a nucleophile, is described. Solvent dependent nitrations of 4‐nitro‐3(5)‐(1′‐pyrazolyl)pyrazole I are reported.
Cyclisation indolique selon bischler en presence d'acides de Lewis
Authors: Galons Hervé , Girardeau Jean‐François , Farnoux Claude Combet , Miocque Marcel 
Published: March 2009

AbstractL'étude comparative de divers catalyseurs (acide chlorhydrique et acides de Lewis) dans la cyclisation des α‐aminocétones selon Bischler, a montré que le chlorure d'aluminium est le plus actif. L'isomérisation des indoles β en α s'observe lorsque les réactions sont conduites à température élevée; son mécanisme paraǐt différent de celui invoqué par la plupart des auteurs puisqu'elle ne porte pas sur les aminocétones mais sur les indoles.
Synthèse de polyéthers polycycliques. 1 Stéréosélectivité de l'hétérocyclisation d'alcools tétrahydrofurfuryliques γ,δ‐éthyléniques par les sels mercuriques
Authors: Amouroux Roger , Chastrette Francine , Chastrette Maurice 
Published: March 2009

AbstractL'hétérocyclisation par oxymercuration intramoléculaire des (tétrahydrofuryl‐2)‐1 pentène‐4 ‐ols‐1, érythro et thréo, est réalisés de manière stéréosélective par l'acétate mercurique. Le méthyl‐2 tétrahydrofuryl‐5 tétrahydrofuranne obtenu après démercuration par réduction contient plus de 80% de l'isomère trans. En revanche la cyclisation par le chlorure mercurique conduit, après réduction, à un mélange d'isomères cis et trans en quantités voisines.
Structure and reactions of a thiazolino[3,2‐a]pyrimidine carbinolamine
Authors: Campaigne E. , Folting K. , Huffman J. C. , Selby T. P. 
Published: March 2009

AbstractEthyl 4‐chloroacetoacetate condenses with 4‐amino‐6‐hydroxy‐2‐pyrimidinethiol to yield ethyl 3‐hydroxy‐5‐oxo‐7‐aminothiazolino[3,2‐a]pyrimidin‐3‐acetate (3), and not ethyl 3‐hydroxy‐5‐amino‐7‐oxothiazolino[3,2‐a]‐pyrimidin‐3‐acetate, as previously reported. This compound reacts with ammonia to produce ethyl 4‐(6′‐amino‐4′‐oxo‐2′‐pyrimidinethiol)‐3‐aminocrotonate (8), the open chain structure of which accounts for the cyclization of 3 to the poly‐cyclic lactam, 6a‐hydroxy‐5,6,6a,7‐tetrahydro‐8‐thia‐1,4‐diazacycl[3.3.2]azine‐2,5‐dione, rather than the sterically more favorable lactone, when 3 was treated with triethylamine. Some other reactions of 3 are described, and the structures of 3 and 8 were comfirmed by single crystal X‐ray diffraction analysis.
Synthesis of New 1H‐indazole derivatives
Authors: Al‐Hajjar Farouk H. , Hamoud Hayat S. 
Published: March 2009

AbstractReactions of 3‐aryl‐1‐phenyl‐2‐propen‐1‐ones IIa‐d with ethyl phenylacetate (I) in the presence of sodium ethoxide under reflux for one hour gave only the corresponding 3,5‐diaryl‐2,4‐dibenzoyl‐6‐phenyl‐cyclo‐hexanones IIIa‐d. The reaction of these compounds with hydrazine hydrate afforded the corresponding 5‐benzoyl‐4,6‐diaryl‐3,7‐diphenyl‐1,4,5,6,7‐pentahydro‐1H‐indazole IVa‐d. The structures of the products were established by spectroscopic (ir, uv, nmr and mass spectra), single‐crystal X‐ray analysis and chemical evidence.
Synthesis of some 2,9‐disubstituted‐1,10‐phenanthrolines
Authors: Chandler Christopher J. , Deady Leslie W. , Reiss James A. 
Published: March 2009

AbstractA series of symmetrically disubstituted compounds, with substituents linked to the ring through a carbon atom, has been prepared from 2,9‐dimethyl‐1,10‐phenanthroline. Nmr data are also reported.
Bipyrans for electrochemical studies. Preparation of polyene‐separated bipyrans and bithiopyrans
Authors: Reynolds G. A. , Chen C. H. 
Published: March 2009

Abstract4,4′‐(But‐2‐ene‐1,4‐dienylidene)‐bi‐4H‐pyran and thiopyran derivatives were prepared by allowing the anion prepared from diethyl 4‐(2,6‐diphenyl‐4H‐pyranyI)phosphonate to react with 4‐pyranylidene butenaldehydes or the corresponding thiopyranylidene aldehydes. The oxidation potentials are compared of some bi‐4H‐pyrans and thiopyrans with zero, two, and four methenyl groups separating the heterocyclic nuclei.
1,3‐benzoxathioles. A simple synthesis of 3‐substituted 2‐hydroxybenzenethiols
Authors: Bernard Angela Maria , Cabiddu Salvatore , Piras Pier Paolo , Sotgiu Francesco 
Published: March 2009

AbstractA convenient synthesis of 3‐substituted‐2‐hydroxybenzenethiols utilizing 7‐substituted‐1,3‐benzoxathioles is described. The structures of the prepared compounds were determined by spectroscopic methods.
Stereochemical assignments of the 7‐phenyl‐3‐oxabicyclo[4.1.0]heptanes
Authors: Corbin Dale H. , Hobbs Gregory D. , Woodyard James D. 
Published: March 2009

AbstractA method for making stereochemical assignments based on nmr data for the 7‐phenyl‐3‐oxabicyclo[4.1.0]‐heptanes is described.
Preparation of some functionalized quinoxaline 1,4‐dioxides
Authors: Usta J. A. , Haddadin M. J. , Issidorides C. H. , Jarrar A. A. 
Published: March 2009

AbstractThe preparation of some functionalized quinoxaline 1,4‐dioxides is described from the reaction of benzofurazan oxide with 2‐acetylbutyrolactone, ethyl acetopyruvate, and acetylacetaldehyde dimethylacetal.
Synthesis and antimicrobial testing of 2‐amino‐6‐hydroxymethyl‐4‐(3H)pyrido[3,2‐d]pyrimidinone
Authors: Kelley James L. , Mclean Ed W. 
Published: March 2009

AbstractSynthesis of 2‐amino‐6‐hydroxymethyl‐4‐(3H)pyrido[3,2‐d]pyrimidinone (5) from 2‐amino‐6‐methyl‐4‐(3H)‐pyrido[3,2‐d]pyrimidinone (2) was accomplished by selenium dioxide oxidation of 2 to the aldehyde 4 followed by sodium borohydride reduction. Compound 2 was available in four steps from 5‐aminouracil or in two steps from 5‐nitroisocytosine (3a). Catalytic reduction of 4 or 5 gave a mixture of 2‐amino‐6‐methyl‐5,6,7,8‐tetrahydro‐4‐(3H)pyrido[3,2‐d]pyrimidinone (6a) and the 6‐hydroxymethyl compound 6b. These compounds showed only weak inhibitory activity in the coupled reactions catalyzed by 7,8‐dihydro‐6‐hydroxymethylpterin pyrophosphokinase and 7,8‐dihydropteroate synthetase from E. Coli. No significant antibacterial activity was observed.
Reactions with diazoazoles. Part IV. . [7 + 2]‐ and [11 + 2]‐cyclocondensation reactions of diazoazoles with acyltriphenylphosphonium methylides to azolo[5,1‐c][1,2,4]triazines
Authors: Ege GÜNter , Gilbert Karlheinz 
Published: March 2009

AbstractAcyltriphenylphosphoniummethylides react with diazoazoles in a [2 + 7]‐ or [2 + 11]‐cycloaddition reaction followed by elimination of triphenylphosphane oxide to yield azolo[5,1‐c][1,2,4]triazines.
Synthesis of 2‐aminochromones. Studies on the nucleophilic displacement of sulphinyl and sulphonyl groups in the 2‐position of 5,8‐dimethoxychromone
Authors: Bantick J. R. , Suschitzky J. L. 
Published: March 2009

AbstractThe synthesis is described of a number of N‐substituted 2‐amino‐5,8‐dimethoxychromones (1) by replacement of the sulphoxide group in 2‐ethylsulphinyl‐5,8‐dimethoxychromone (5a) with the appropriate amine. Analogous substitution of 2‐ethylsulphonyl‐5,8‐dimethoxychromone (5b) is also possible but limited by the instability of the sulphone. Replacement reactions of 5a involving oxygen, sulphur, and phosphorus nucleophiles are also described.
Synthesis of the novel isoquinoline enamide alkaloid polycarpine
Authors: Lenz George R. , Woo Chi‐Min 
Published: March 2009

AbstractThe synthesis of the novel enamide isoquinoline alkaloid polycarpine, (Z)‐1‐(2′‐hydroxy‐3′,4′‐dimethoxy‐benzylidene)‐3,4‐dihydro‐6,7‐dimethoxy‐2‐(1H)isoquinolinecarboxaldehyde, proceeding from commercially available 2′,3′,4′‐trimethoxyacetophenone in seven steps is described. TheO‐methyl andO‐benzyl derivatives were also obtained.