bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Practical Wisdom Cannot be Eliminated
Authors: De Caro Mario , Navarini Claudia , Vaccarezza Maria Silvia 
Published: March 2024

AbstractPractical wisdom eliminativism has recently been proposed in both philosophy and psychology, on the grounds of the alleged redundancy of practical wisdom (Miller 2021) and its purported developmental/psychological implausibility (Lapsley 2021). Here we respond to these challenges by drawing on an improved version of a view of practical wisdom, the “Aretai model”, that we have presented elsewhere (De Caro et al. 2021; Vaccarezza et al. 2023; De Caro et al. forthcoming). According to this model, practical wisdom is conceptualized: (i) as virtuousness tout court, i.e., as the ratio essendi of the virtues, and (ii) as a form of ethical expertise. By appealing to the first thesis, we counter the charge of psychological implausibility, while we rely on the second thesis to address the accusation of redundancy. In conclusion we argue that the Aretai model implies a significant paradigm shift in virtue ethics. Practical wisdom emerges as both necessary and sufficient for virtuousness, thereby downsizing – without eliminating entirely – the role that individual virtues play in our ethical lives.
A MWCNTs@CuAl2O4@SiO2 Nanocomposite for the Speciation of Cr(III), Cr(VI), and Total Chromium Prior to High-Resolution Continuum Source Flame Atomic Absorption Spectrometric Determination
Authors: Ahmed Hassan Elzain Hassan , Soylak Mustafa 
Published: March 2024

AbstractA solid-phase microextraction (SPME) method had been applied to speciate chromium in natural and wastewater samples. MWCNTs@CuAl2O4@SiO2 nanocomposite was synthesized by sol–gel and calcination methods and then characterized using SEM, FTIR, and XRD techniques. MWCNTs@CuAl2O4@SiO2 was used to extract Cr(VI) as pyrrolidine dithiocarbamate chelates. Some analytical parameters involving pH, ligand (APDC) and adsorbent amounts, sample initial and final volume, and the effects of matrices were tested and optimized. For the oxidation of Cr(III) to Cr(VI), potassium permanganate was used, and after that, the presented method was applied to determine the total chromium levels. The calculations were carried out to obtain Cr(III) concentration by finding differences between total chromium and Cr(VI) concentrations. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 6.2 µg L−1 and 20.8 µg L−1, respectively. The proposed method was successfully applied for chromium speciation in wastewater samples.
Inter-night variability of in-home, overnight pulse oximetry screening in an asymptomatic older adult population
Authors: Chaudhary Attiqa , Abbott Carla J. , Wu Zhichao , Fang Wendy Y. , Raj Palaniraj R. , Naughton Matthew T. , Guymer Robyn H. 
Published: March 2024

Abstract
Purpose
Obstructive sleep apnoea (OSA) is common, yet often undiagnosed. Self-administered, overnight pulse oximetry (OPO) could screen for OSA in asymptomatic, older populations. However, the inter-night variability of OPO in an asymptomatic, older population is unknown. We determined the inter-night variability of home OPO parameters in an older population and correlated with sleep questionnaires.

Methods
Participants > 50 years without a diagnosis of OSA undertook home OPO for three consecutive nights and completed two sleep questionnaires (STOP-BANG (SBQ) and Epworth Sleepiness Score (ESS)). Analysis was performed with linear mixed models and Spearman’s correlation coefficient.

Results
There was no difference in oxygen desaturation index (ODI), MeanSpO2, MinimumSpO2, and time spent with SpO2 < 90% (T90) across two or three nights (P ≥ 0.282). However, the variability of all parameters across nights increased with the magnitude of departure from normal values (P ≤ 0.002). All OPO parameters were associated with age (P ≤ 0.034) and body mass index (P ≤ 0.049). There was a weak correlation between three OPO parameters and SBQ (absolute ρ = 0.22 to 0.32; P ≤ 0.021), but not ESS (P ≥ 0.254).

Conclusion
Inter-night variability of home OPO was minimal when values were near-normal in an older population. However, as values depart from normal, the inter-night variability increases, indicating the need for multiple night recordings. Low correlation to sleep questionnaires suggest the need for more robust OSA questionnaires in an asymptomatic population.
Microscopic origins of shape effects on migration and clogging of fines in porous media using coupled CFD-iDEM
Authors: Xiong Hao , Zhang Zhimin , Yin Zhen-Yu , Chen Xiangsheng , Zhou Wanhuan 
Published: March 2024

AbstractThe unstable mechanical behavior of soil particles during suffusion, including migration and clogging of fine particles in porous media, is prone to induce seepage catastrophes. Mechanical behavior of migratory fines and porous soils during suffusion is significantly influenced by the particle shape, which remains unclear. In this study, a coupled computational fluid dynamics and the irregular discrete element method (CFD-iDEM) framework is developed to investigate the migration and clogging mechanisms. A series of numerical simulations that consider spheres and irregular particles with different levels of aspect ratio are carried out to elucidate the microscopic origins of shape effects on clogging. Migratory fine particles are discharged from the grain inlet and enter the coarse particle skeleton by imposing a downward seepage flow. The subsequent migration and clogging phenomena and microscopic mechanisms are investigated. The results reveal that irregular particles present varying degrees of ability to develop clogging clusters, and spheres are more prone to traverse deeper into soil skeleton. The proposed CFD-iDEM method is able to reproduce macroscopic phenomena of saturated porous medium as well as to analyze microscopic origins of fluid–particle interactions, which contributes to practical guidance for engineering applications.
Successful Life Conduct in Very Old Age: Theoretical Implications and Empirical Support from a Population-Based Study
Authors: Kaspar Roman , Albrecht Andrea , Brijoux Thomas , Fey Jonas , Geithner Luise , Oswald Veronica , Reissmann Marcella , Wagner Michael , Wenner Judith , Zank Susanne , Zimmermann Jaroslava 
Published: March 2024

AbstractSocial survey data on those aged 80 years or older is sparse. Based on a representative sample, this paper validates a multidimensional model proposed for understanding of quality of life (QoL) in very old age. Towards this goal, this paper estimated levels and heterogeneity of personal and environmental resources, well-being, autonomy, and perceived appreciation by society in the population of the very old in Germany. Next, the contribution of personal and environmental resources to QoL outcomes and overlap between these outcomes was estimated using a multivariate approach. Results were based on a representative survey on QoL of the very old in North Rhine-Westphalia, Germany’s most populous state. The survey included comprehensive information on socio-demographics, health, social and personal QoL resources including objective testing of cognitive function. The sample comprised 1,863 individuals (mean age 86.5 years, range 80–102 years), including 211 individuals residing in non-private dwellings. Interviews with proxy informants were conducted for 176 individuals that were willing to participate but could not conduct the interview themselves due to limited ability to communicate (PLC). Pronounced differences were found for PLC with respect to environmental and personal resources and QoL outcomes. Pronounced differences were also found both with respect to lower observed levels of QoL outcomes (e.g., autonomy) and predictors of QoL outcomes (e.g., effect of negative “external” appreciation on subjective well-being). Contrary to the deficit-oriented model of old age, a high degree of autonomy was observed. However, substantial and consequential negative “external” appreciation of very old age was also apparent.
Machine learning approach using 18F-FDG-PET-radiomic features and the visibility of right ventricle 18F-FDG uptake for predicting clinical events in patients with cardiac sarcoidosis
Authors: Nakajo Masatoyo , Hirahara Daisuke , Jinguji Megumi , Ojima Satoko , Hirahara Mitsuho , Tani Atsushi , Takumi Koji , Kamimura Kiyohisa , Ohishi Mitsuru , Yoshiura Takashi 
Published: March 2024

Abstract
Objectives
To investigate the usefulness of machine learning (ML) models using pretreatment 18F-FDG-PET-based radiomic features for predicting adverse clinical events (ACEs) in patients with cardiac sarcoidosis (CS).

Materials and methods
This retrospective study included 47 patients with CS who underwent 18F-FDG-PET/CT scan before treatment. The lesions were assigned to the training (n = 38) and testing (n = 9) cohorts. In total, 49 18F-FDG-PET-based radiomic features and the visibility of right ventricle 18F-FDG uptake were used to predict ACEs using seven different ML algorithms (namely, decision tree, random forest [RF], neural network, k-nearest neighbors, Naïve Bayes, logistic regression, and support vector machine [SVM]) with tenfold cross-validation and the synthetic minority over-sampling technique. The ML models were constructed using the top four features ranked by the decrease in Gini impurity. The AUCs and accuracies were used to compare predictive performances.

Results
Patients who developed ACEs presented with a significantly higher surface area and gray level run length matrix run length non-uniformity (GLRLM_RLNU), and lower neighborhood gray-tone difference matrix_coarseness and sphericity than those without ACEs (each, p < 0.05). In the training cohort, all seven ML algorithms had a good classification performance with AUC values of > 0.80 (range: 0.841–0.944). In the testing cohort, the RF algorithm had the highest AUC and accuracy (88.9% [8/9]) with a similar classification performance between training and testing cohorts (AUC: 0.945 vs 0.889). GLRLM_RLNU was the most important feature of the modeling process of this RF algorithm.

Conclusion
ML analyses using 18F-FDG-PET-based radiomic features may be useful for predicting ACEs in patients with CS.
SiC-YAG Coating Microstructure Optimization Through Powder Feedstock Manufacturing Process Control
Authors: Perello-Badia D. , Espallargas N. 
Published: March 2024

AbstractA silicon carbide/yttrium aluminum garnet (SiC/YAG) composite powder feedstock material developed and patented by NTNU (Norway) in 2012 has been used to produce industrial SiC thermal spray coatings since 2014. This powder is the first of its kind in the thermal spray industry. The commercial powder is produced by the agglomerated and sintered route (A&S), making it suitable mostly for High-Velocity Oxygen Fuel, but it can also be produced by the sintered and crushed (S&C) manufacturing route for Atmospheric Plasma Spray (APS). In this work, a S&C route is proposed using jaw crusher, hammer mill, and ball milling techniques. The resulting powders were then deposited using APS and were compared with the reference A&S powder. The chemistry and the microstructure of the powders and coatings were characterized using electron microscopy, x-ray diffraction, and Vickers microhardness. The S&C powders showed a density higher than the A&S powder and a blocky morphology. The S&C powders had almost no internal porosity and kept the same chemical composition as the A&S version. The coatings obtained with the S&C powders outperformed the A&S coatings, having less porosity, higher hardness, and no secondary phases.
Optimizing outcome reporting after robotic flexible ureteroscopy for management of renal calculi: Introducing the concept of tetrafecta
Authors: Salah Morshed , Laymon Mahmoud , Gul Tawiz , Alnawasra Hossameldin , Ibrahim Mohammed , Tallai Bela , Ebrahim Mohamed , Alrayashi Maged , Abdelkareem Mohamed , Al-Ansari Abdulla 
Published: March 2024

AbstractRobotic flexible ureteroscopy (RFURS) has shown encouraging results in terms of stone free rate (SFR) and better ergonomics compared to conventional FURS. However, few studies have reported its outcomes. The goal of this study was to report our initial results of RFURS, furthermore we proposed a novel metrics for composite outcome reporting named tetrafecta. A retrospective analysis of electronic records of 100 patients treated with RFURS for renal stones between 2019 till 2023 was performed. Tetrafecta criteria included, complete stone removal after a single treatment session, without auxiliary procedures, absence of high-grade complications (GIII-V) and same-day hospital discharge. Mean patient age and stone size were 40.7 ± 9.2 and 11.7 ± 5.8 mm, respectively. Median stone volume was 916 (421–12,235) mm3. Twenty-eight patients had multiple renal stones. Staghorn stones were seen in 12 patients. Preoperative DJ stent was fixed in 58 patients. Median operative time and stone treatment time were 116 min (97–148) and 37 (22–69) min. The median stone treatment efficiency (STE) was 21.6 (8.9–41.6). A strong positive correlation between stone volume and STE (R = 0.8, p < 0.0001). Overall, 73 patients were stone free after the initial treatment session while tetrafecta was achieved in 70 patients. Univariate analysis showed that the stone size (p = 0.008), acute infundibulopelvic angle (p = 0.023) and preoperative stenting (p = 0.017) had significant influence on achieving tetrafecta. Multivariate analysis identified preoperative stenting (OR 0.3, 95% CI 0.1–0.8, p = 0.019) as the only independent predictor of tetrafecta achievement. A comprehensive reporting methodology for reporting outcomes of RFURS is indicated for patient counseling and comparing different techniques. Tetrafecta was achieved in 70% of cases. Presence of significant residual stones ≥ 3mm was the leading cause of missing tetrafecta. Absence of preoperative stent was the only predictor of missing tetrafecta.
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Authors: Marin Concepció , Alobid Isam , López-Chacón Mauricio , VanStrahlen Camilo R. , Mullol Joaquim 
Published: March 2024

Abstract
Purpose of Review
Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfactory function, but is impaired during chronic type 2 and non-type 2 inflammation of the upper airways. In this review, we describe the neurobiology of olfaction and the olfactory alterations in chronic rhinosinusitis with nasal polyps (type 2 inflammation) and post-viral acute rhinosinusitis (non-type 2 inflammation), highlighting the role of immune response attenuating olfactory neurogenesis as a possibly mechanism for the loss of smell in these diseases.

Recent Findings
Several studies have provided relevant insights into the role of basal stem cells as direct participants in the progression of chronic inflammation identifying a functional switch away from a neuro-regenerative phenotype to one contributing to immune defense, a process that induces a deficient replacement of olfactory neurons. The interaction between olfactory stem cells and immune system might critically underlie ongoing loss of smell in type 2 and non-type 2 inflammatory upper airway diseases.

Summary
In this review, we describe the neurobiology of olfaction and the olfactory alterations in type 2 and non-type 2 inflammatory upper airway diseases, highlighting the role of immune response attenuating olfactory neurogenesis, as a possibly mechanism for the lack of loss of smell recovery.
Pregnancy and delivery in an advanced cancer survivor with immune checkpoint inhibitor-induced type 1 diabetes: a case report
Authors: Sugai Keiji , Miwa Takashi , Kojima Junya , Ueda Yuri , Tsukahara Kiyoaki , Nishi Hirotaka , Suzuki Ryo 
Published: March 2024

Abstract
Purpose
Given the rarity and elderly onset of immune checkpoint inhibitor (ICI)-induced type 1 diabetes (ICI-T1DM), cases leading to delivery are rare.

Method
To our knowledge, this is the first case report of childbirth in a patient with ICI-T1DM after cancer survival. A 32-year-old woman was started on Nivolumab for metastatic parotid cancers one year after total parotidectomy.

Result
The patient developed ICI-T1DM after 43 cycles and started multiple daily insulin therapy and self-monitoring of blood glucose. Complete response was maintained for 2 years by nivolumab, and she finished nivolumab in 77 cycles to attempt pregnancy. During the follow-up period, she began using a sensor-augmented pump (SAP). She had undetectable serum and urinary C-peptide when she started SAP. Her HbA1c level decreased from 7.8 to 6.6% without increasing hypoglycemia in one year. The patient remained in complete response after ICI discontinuation, and embryo transfer was initiated. Pregnancy was confirmed after a second embryo transfer (21 months after ICI discontinuation). At 36 weeks and 6 days, an emergency cesarean section was performed due to the onset of preeclampsia. The baby had hypospadias and bifid scrotum but no other complications or neonatal intensive care unit admission.

Conclusion
Because ICI discontinuation and ICI-T1DM carry risks for the patient and child, the decision regarding pregnancy warrants careful consideration. Diabetologists should collaborate with patients and other clinical departments to develop a treatment plan for childbirth.
Updates to the Melbourne Children’s Regional Infant Brain Software Package (M-CRIB-S)
Authors: Adamson Chris L. , Alexander Bonnie , Kelly Claire E. , Ball Gareth , Beare Richard , Cheong Jeanie L. Y. , Spittle Alicia J. , Doyle Lex W. , Anderson Peter J. , Seal Marc L. , Thompson Deanne K. 
Published: March 2024

AbstractThe delineation of cortical areas on magnetic resonance images (MRI) is important for understanding the complexities of the developing human brain. The previous version of the Melbourne Children's Regional Infant Brain (M-CRIB-S) (Adamson et al. Scientific Reports, 10(1), 10, 2020) is a software package that performs whole-brain segmentation, cortical surface extraction and parcellation of the neonatal brain. Available cortical parcellation schemes in the M-CRIB-S are the adult-compatible 34- and 31-region per hemisphere Desikan-Killiany (DK) and Desikan-Killiany-Tourville (DKT), respectively. We present a major update to the software package which achieves two aims: 1) to make the voxel-based segmentation outputs derived from the Freesurfer-compatible M-CRIB scheme, and 2) to improve the accuracy of whole-brain segmentation and cortical surface extraction. Cortical surface extraction has been improved with additional steps to improve penetration of the inner surface into thin gyri. The improved cortical surface extraction is shown to increase the robustness of measures such as surface area, cortical thickness, and cortical volume.
Determination of the onset of yielding and the Young’s modulus after a change in the loading direction
Authors: Norz Roman , Vitzthum Simon , Gruber Maximilian , Maier Lorenz , Kornmeier Joana Rebelo , Maawad Emad , Valencia Fabuer R. , Gerke Steffen , Brünig Michael , Volk Wolfram 
Published: March 2024

AbstractThe onset of plastic deformation is an important parameter for an accurate description of the flow curve and the Young’s modulus. Determining the actual physical start of flow is already experimentally challenging for classic sheet metal materials. In addition to the experimental challenge, the onset of flow depends on numerous parameters such as strain rate, temperature and forming history. Non-proportional load paths in particular can significantly influence the onset of flow. Three different materials, a micro-alloyed steel HC340LA, a dual-phase steel CR330Y590-DP and an aluminium alloy AA6016-T4 are investigated in this publication. The physical onset of flow of the materials is determined at three different pre-strain levels as well as without and with a change in the load direction. Temperature-based approaches are used for this purpose. In-situ synchrotron diffraction is used to validate the results obtained. Those results can help to improve existing material models and springback prediction. Such models rely on material parameters that are as accurate as possible.
Risks beyond the ditch: Copper Age tannery from the settlement of Kamianets-Podilskyi (Tatarysky), Ukraine
Authors: Sobkowiak-Tabaka Iwona , Gerasimenko Natalia , Kurzawska Aldona , Kufel-Diakowska Bernadeta , Moskal-del Hoyo Magdalena , Stróżyk Mateusz , Rohozin Yevhenii P. , Ridush Bogdan , Levinzon Yevhenii , Boltaniuk Petro , Nechytailo Pavlo , Diachenko Aleksandr 
Published: March 2024

AbstractThe evolution of Neolithic to Bronze Age settlement organization in Central Europe has revealed ditches as an important component of settlement structures. The various shapes and sizes of these features contribute to different understandings of their functions, mainly referring to ditches as elements of fortifications or ritual practices. Based on a newly discovered Copper Age feature at Kamianets-Podilskyi (Tatarysky), Ukraine, our paper contributes to the discussion on the function of ditches in their relation to prehistoric technologies. This study presents evidence on tanning techniques and technologies associated with a section of ditch belonging to the Western Trypillia culture. Due to the uniqueness of this discovery, we applied various analyses, including GIS spatial analyses, palynological, anthracological, archeozoological, malacological, and use-wear studies. The obtained results enable us to recognize the complex practices of Copper Age communities, skillfully combining technical knowledge with an understanding of environmental conditions.
Enhancing collagen based nanoemulgel for effective topical delivery of Aceclofenac and Citronellol oil: Formulation, optimization, in-vitro evaluation, and in-vivo osteoarthritis study with a focus on HMGB-1/RAGE/NF-κB pathway, Klotho, and miR-499a
Authors: Aldeeb Reem Abd Elhameed , Ibrahim Sherihan Salaheldin Abdelhamid , Khalil Islam Ahmed , Ragab Ghada Mohamed , El-Gazar Amira Ahmed , Taha Amal Anwar , Hassan Doaa Hussien , Gomaa Asmaa Ahmed , Younis Mona Kamal 
Published: March 2024

AbstractThe majority of conventional osteoarthritis (OA) treatments are based on molecular adjustment of certain signaling pathways associated with osteoarthritis (OA) pathogenesis, however there is a significant need to search for more effective and safe treatments. This study centers around formulating Aceclofenac (ACF) with high bioavailability in combination with Citronellol oil and collagen. The optimal concentrations of Citronellol oil/D-Limonene oil, Tween 80, and Transcutol HP were determined using a pseudoternary phase diagram. The formulated nanoemulsions were studied for thermophysical stability. Thermodynamically stable formula were analyzed for droplet size, zeta potential, and in-vitro permeation. Then, collagen based nanoemulsion were prepared to capitalize on its efficacy in reducing osteoarthritis side effects and characterized for nano size properties. Formulae F10 and F10C were chosen as optimum nanosize formula. Hense, they were prepared and characterized as nanoemulgel dosage form. The nanoemulgel formulae F10NEG1 and F10CNEG1 showed reasonable viscosity and spreadability, with complete drug release after 4 h. These formulae were chosen for further In vivo anti-OA study. Collagen based ACF/citronellol emugel were able to modulate HMGB-1/RAGE/NF-κB pathway, mitigating the production of inflammatory cytokine TNF-α. They were also able to modulate Klotho and miR-499, reducing serum CTXII and COMP, by reducing the cartilage destruction. Histological investigations validated the efficacy, safety, and superiority of Aceclofenac in combination with Citronellol oil and collagen (F10CNEG1) over solo the treated group (F10NEG1 and blank). Hence, the findings of the current work encourage the use of this promising combined formula in treatment of OA patients.
Graphical abstract