bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Role of Thrombosis, Fenestration, and False Lumen Orbital Orientation in the Hemodynamics of Type B Aortic Dissection
Authors: Messou Joseph C. E. , Yeung Kelly , Sudbrook Eric , Zhang Jackie , Toursavadkohi Shahab , Ucuzian Areck A. , Tubaldi Eleonora 
Published: March 2024

Abstract

While much about the fundamental mechanisms behind the initiation and progression of Type B aortic dissection (TBAD) is still unknown, predictive models based on patient-specific computational fluid dynamics (CFD) can help in risk stratification and optimal clinical decision-making. Aiming at the development of personalized treatment, CFD simulations can be leveraged to investigate the interplay between complex aortic flow patterns and anatomical features. In this study, the hemodynamics of false lumen thrombosis, a large fenestration, and the orbital orientation of the false lumen is studied through image-based CFD simulations on three TBAD patient-specific geometries. A new pipeline was developed leveraging the open-source software SimVascular and Paraview to analyze multiple patients simultaneously and to achieve large-scale parallelization in CFD results based on patients’ computed tomography (CT) images. The results of this study suggest that the internal orbital orientation of the false lumen contributes to maintaining a positive luminal pressure difference ∆P T L−FL = P T L − P FL between the true lumen (TL) and the false lumen (FL), despite an impingement area in the false lumen near the entry tear. A positive and high luminal pressure difference is thought to promote TL expansion and FL compression. Moreover, it was also found that both FL thrombosis at the entry tear region, and the presence of a large fenestration in the descending thoracic aorta reduce the magnitude of the negative luminal pressure difference, which in turn may reduce FL expansion and the risk of unstable aortic growth.
Assessing the Use of Geospatial Data for Immunization Program Implementation and Associated Effects on Coverage and Equity in the Democratic Republic of Congo
Authors: Ngo-Bebe Dosithée , Mechael Patricia , Kwilu Fulbert Nappa , Bukele Théophane Kekemb , Langwana Félicité , Lobukulu Genèse Lolimo , Kalonji Marcelo Ilunga , Kalalizi Bahindwa , Tschirhart Kevin , Luhata Christophe Lungayo , Gachen Carine 
Published: March 2024

Abstract

Background
The National Expanded Program on Immunization in the Democratic Republic of the Congo started using geospatial data at scale in 8 Provinces to strengthen the planning and implementation of vaccination services with a focus on the identification and immunization of zero-dose children, children who have not received the first dose of diphtheria-tetanus-pertussis containing vaccine (DTP1).
Methods
The study used a mixed-methods research design including survey tools, in-depth interviews and direct observation to document the uptake, use, and perceived impact of georeferenced immunization microplans in the intervention provinces of Haut-Lomami and Kasai and in the control province of Kasai Central. A total of 113 health facilities in 98 Health Areas in 15 Health Zones in the three provinces were included in the study sample. A gender intervention in select Health Zones and Health Areas in Kasai Province was also evaluated through a targeted qualitative study. A secondary analysis of immunization coverage survey data was conducted to assess the associated effects on immunization coverage, especially for rates of zero-dose children.
Results
This research study shows that georeferenced microplans are well received, utilized, and led to changes in routine immunization service planning and delivery with perceived improvements in identification and reaching zero-dose children. In addition, the gender intervention is perceived to have led to a significant change in the approaches taken to overcome sociocultural gender norms and engage communities to reach as many children as possible, leveraging the ability of women to engage more effectively to support vaccination services. The quantitative analyses showed that georeferenced microplans may have contributed to a dramatic and sustained trend towards high immunization coverage in the intervention site of Haut Lomami, which rose dramatically from 8.9% in 2020 to 76.8% in 2021 and to 92% in 2022 for Pentavalent 3 antigen, while the DPT1-DPT3 drop-out rate changed little from 1% in 2020 to 1.7% in 2021 and 1.6% in 2022 after three years of implementation.
Conclusion
The overall study identified positive contributions of the georeferenced data in the planning and delivery of routine immunization services. It is recommended to conduct further analyses in Kasai in 2024 and 2025 to evaluate the effects of the gender intervention on immunization coverage and equity outcomes.
Deep Learning Insights into ASD: Classifying and Unveiling Behavioural Patterns through RoBERTa and Topic Modeling on QCHAT Data.
Authors: Bae Soo Kyung , Kim Hwiyoung , Lee Chaewon 
Published: March 2024

Abstract
This study leverages advanced Natural Language Processing (NLP) models, including Bidirectional Encoder Representations from Transformers (BERT), A Robustly Optimized BERT Pretraining Approach (RoBERTa), and Topic Modeling, to analyze behavioral patterns in Autism Spectrum Disorder (ASD). Using the Quantitative Checklist for Autism in Toddlers (QCHAT) dataset enhanced with ASD-related behavioral terms, we demonstrate the potential of these models to improve ASD vs. Typically Developing (TD) classification accuracy and uncover key behavioral themes indicative of ASD. Our findings highlight the value of enriching clinical datasets with domain-specific knowledge and showcase the power of adapting deep learning techniques for ASD research. This work contributes to developing more accurate and informative ASD diagnostic tools.
Biosynthesis of silver nanoparticles from the marine bacterium Marinobacter litoralis CARE V18 strain and evaluation of its antibacterial, antioxidant and acute toxicity properties using Zebrafish model
Authors: Sakthivel Vignesh , Narasimman Vignesh , Ravi Karthikeyan , Dhanya Gopika , Prasad Keerthana , Ramachandran Saravanan 
Published: March 2024

Abstract
Biosynthesized silver nanoparticles (Ag-NPs) hold great potential for preventing, treating, diagnosing, and controlling diseases. The primary objective of this study is on marine halophilic bacteria (Marinobacter litoralis CARE-V18) and their extracellular synthesis of Ag-NPs. The marine bacterial synthesized Ag-NPs is characterized using dynamic light scattering (DLS), zeta potential analysis (ZPA), fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray (EDX), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The antibiofilm and antibacterial activity of the bacterially synthesized Ag-NPs against human bacterial pathogens are tested (A. baumannii, K. pneumonia, and MRSA). Furthermore, the acute toxicity effects of Ag-NPs in zebrafish embryos (ZFE) (Danio rerio) are also examined in this study. The acute toxicity of Ag-NPs at different time points of post-fertilization (3, 12, 24, 48, 72, and 96 hours) eggs of zebrafish. Results shows dose-dependent antibacterial and antibiofilm activity, with significant inhibition observed at 100 and 200 μg/ml concentrations against A. baumannii, K. pneumonia, and MRSA. The lethal concentration (LC50) values determined as 12.5 and 50 μg/ml. The acute toxicity of Ag-NPs treated ZFE are displayed concentration-dependent mortality rates and increased hatching delay.
Thin delivery stents can obviate the need for additional fistula dilatation of large diameter in endoscopic ultrasound-guided hepaticogastrostomy
Authors: Ogata Tomoki , Kurita Yusuke , Sato Takamitsu , Yagi Shin , Hasegawa Sho , Hosono Kunihiro , Kobayashi Noritoshi , Endo Itaru , Kubota Kensuke , Nakajima Atsushi 
Published: March 2024

Abstract
Background
Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) often requires fistula dilation owing to the placement of large diameter of the delivery stent. The recently developed delivery devices as thin as 5.9/6.0 Fr may save the need for fistula dilation. Therefore, we investigated whether the large fistula dilation would be required or not in case of this newly developed thin diameter delivery stents.
Methods
We conducted a retrospective study involving 33 patients implemented with self-expandable metal stent (SEMS) during EUS-HGS. The patients were categorized based on the delivery device diameter into thin (n = 13; delivery device diameter: 5.9/6.0 Fr) and thick (n = 20; delivery device diameter: 8.5 Fr) groups. We compared the initial rate of success, technical success, and clinical success between the thin and thick groups. Initial rate of success was defined as successful stent placement without a balloon or large diameter mechanical dilation.
Results
The rate of initial stenting success was significantly higher in the thin group (100% [13/13]) compared with that in the thick group (65.0% [13/20]) (p = 0.027). In the thick group, seven cases with technical difficulty in stent placement could be successfully completed with additional fistula dilation with 9Fr bougie dilator, or 4mm balloon dilator; this resulted in a technical success of 100% in both groups ultimately. The rate of clinical success was 100% and 95.0% in the thin and thick groups, respectively (p = 1.00).
Conclusions
Thin-delivery stents may facilitate stent placement without the need for a balloon fistula or large-diameter mechanical dilation.
Acoustophoretic in situ 3D fabrication of multi-material and porous structures
Authors: Chen Hongyi , Bansal Shubhi , Plasencia Diego Martinez , Huang Jie , Subramanian Sriram , Hirayama Ryuji 
Published: March 2024

Abstract
Additive manufacturing is critical in modern production, from individualized prototyping to advanced applications across various domains1-5. However, it has several challenges, including the integration of multiple materials with diverse properties into a single print without cross-contamination6, printing on complex surfaces7, and generating customized porous structures8. Here, we present AcoustoFab, an acoustophoretic fabrication system that is capable of in situ multi-material 3D printing with customized porous structures on complex substrates in a contactless manner. Our system utilizes a phased array of ultrasound transducers to precisely control sound fields in 3D space, allowing acoustic levitation of diverse materials (e.g., edible, fluorescent, luminant, and ferromagnetic) and depositing them on complex or non-planar surfaces during the additive manufacturing process. Additionally, we utilize ultrasound focusing to create high-pressure points on the target locations to generate customized porous structures to tune the texture, appearance, and flexibility. AcoustoFab stands out not only as an independent fabrication system but also for its compatibility with existing platforms, such as stereolithography, demonstrated through multi-material printing experiments, which highlights its potential for augmenting current fabrication technologies. AcoustoFab offers opportunities for non-contact, multi-material in situ printing with customized porous structures for various applications, for example, in situ printing, food engineering, soft actuators, optical devices and bioprinting.
Impact of Infrared Pulsed Laser on Passivated-Textured Silicon Wafers
Authors: Rais Ahmad Rujhan Mohd , Sinin Nurul Aqidah Mohd , Hamid Siti Nor Fazlina Abdul , Sepeai Suhaila , Sopian Kamaruzzaman 
Published: March 2024

Abstract

A textured surface on a silicon solar cell effectively improves solar cell performance by reducing reflection losses. The standard process of pyramidal texturization on silicon wafers is widely implemented in manufacturing and laboratory wet chemical etching. Furthermore, the plasma etching process is usually used to create vertical hole texturization on the surface of silicon. In conjunction with that, laser texturization is known as an alternative method for plasma etching due to user-friendly equipment and a chemical-free process. The passivated pyramidal texturing on silicon wafers is classified as normal texturization. Meanwhile, an improvement of texturization with additional laser texturing on normal texturization Si is known as laser passivated-textured. The transmission of pyramidal textured silicon wafer demonstrates less absorption, and this is due to reflection losses on the front surface of the pyramidal textured silicon wafer. Any texturization will increase the short circuit current (Jsc), open circuit voltage (VOC) and efficiency by minimizing the surface reflection loss through effective photon trapping among textured structures. According to infrared (IR) transmission, a higher laser power of 114 W suggests lower reflection losses. Thus, the results from vertical hole texturization on silicon wafers via IR transmissions and cross-section Field Emission Scanning Electron Microscopy (FESEM) reveal a promising photo generation on the surface. The depth level of vertical holes created by laser due to deeper vertical holes that have been created will reduce the distance of minority carriers and trap more incident light among the walls. In addition, this procedure can be implemented as an alternative method to shorten the distance travel of minority carrier charges, and more light can penetrate deeper solar cells. This, ultimately, will overcome any problems related to optical losses.
A simple enzymatic process for the quercetin and rutinose preparations from rutin
Authors: Singh Shikha , Yadav Kamlesh Singh 
Published: March 2024

Abstract
Both the components of rutin, quercetin and rutinose are pharmaceutically important compounds of medicinal values. A simple process for the preparation of quercetin and rutinose from rutin based on a diglycosidase catalysed reaction has been reported. The diglycosidase is secreted by a fungal strain Fusarium moniliforme MTCC 2015. The enzyme solution as secreted by the fungal strain in its medium has been used for this transformation and purification of enzyme is not required. The potential of the process in the context of available literature has been discussed.
Knowledge of Accident and Emergency Regarding Triage, Initial Assessment of Patients and Resuscitation Among Nurses in Central Region of Ghana
Authors: ASIEDU CHRISTIANA , Mensah Monica , Erzuah Isaac Aidoo 
Published: March 2024

Abstract
Background
Road traffic accidents represent a global health challenge, with approximately 1.3 million fatalities annually, and a staggering 93% of these incidents occurring in low- and middle-income countries.
Purpose
This research focuses on evaluating the level of emergency preparedness in trauma management in the Central Region of Ghana, considering the high prevalence of road traffic accidents in low- and middle-income countries.
Methods
The study utilized a quantitative research design, specifically a cross-sectional survey, to collect data from three public health facilities in the Central Region. All 65 nurses working in the emergency departments of these hospitals were included in the study using a census approach. A structured questionnaire consisting of checklists, true/false items, and multiple-choice questions (MCQs) was used for data collection. The data was analyzed using descriptive statistics and binary logistic regression.
Results
The results revealed that nurses in the Accident and Emergency department had moderate knowledge in the initial assessment and resuscitation of patients, including CPR. However, the study also identified gaps in CPR knowledge among nurses working in the emergency department.
Conclusion
The findings highlight the need for further study and training in triaging for nurses, as well as regular refresher courses and hands-on training opportunities to enhance their skills.
Evaluation of Codium fragile and Turbinaria conoides seaweeds- extracts as a novel larvicidal agent against the Culex quinquefasciatus
Authors: Pachaan Kolanchinathan , Ravi Sujatha , Paramasivan Deepa , Dharmaraj Praveenkumar , Subbiah Vijayakumar Alagan 
Published: March 2024

Abstract
Marine algae possess abundant reserves of bioactive compounds that can host secondary metabolites exhibiting both structural and biological activity. In our present study, the aqueous, ethanol, methanol, and chloroform extract of seaweed such as Codium fragile and Turbinaria conoideswas employed to determine the phytochemical, GC-MS, antioxidant, and larvicidal activity. The phytochemical compounds showed C. fragile and T. conoides ethanolic extract revealed the existence of fourteen numbers of compounds compared to the others. The GC-MS analysis was performed on the ethanolic extract of C fragile and T. conoidesshowed the presence of each of twenty different compounds. C. fragile of Hexadecanoic Acid (27.79%), 4-Methanocycloocta[d]Pyridaz (7.39%), 1,1-Dimethoxy-2-Hepten-7-Al (7.04 %) and Octadecanoic Acid, (5.9%). The T. conaids of Dibutyl phthalate (69.56%), 1,2-Benzenedicarboxylic acid (14.01%) and Phthalic acid (2.58 %) were present as the major constituent with the highest area percentage. The antioxidant activity of different solvents the T. conoides ethanolic extract was found to have the highest DPPH (81.48 ± 1.0%), ABTS (88.29±1.0%) and Hydroxyl radical scavenging (86.51±1.0%) activity followed by other solvent extracts. The chloroform extract of C fragile and T. conoides showed effective Cx. quinquefasciatus larvicidal activity. Therefore, the bioactive substances derived from the ethanolic extracts could be used for the antioxidant and larvicidal activity of chloroform extract which will overcome the synthetic insecticides negative impact on the environment. The seaweed possesses the potential to serve as a promising alternative source for controlling mosquitoes due to its larvicidal properties.
Analysis of EWSR1-CREM fusion sarcoma with ALK protein overe xpression and response to alectinib therapy
Authors: Gao Xiaozhuo , Ma Lin , Zhang Enhao , Huang Bo 
Published: March 2024

Abstract

The molecular changes in soft tissue sarcomas are complex. It has numerous fusion partners, and different fusion partner diseases exhibit different histological morphologies and biological behaviors. A 53-year-old female patient had sarcoma in the left thigh. Imaging revealed a sarcoma shadow in the intermuscular soft tissue of the medial left thigh, suggestive of malignancy. The patient underwent a left thigh mass resection and inguinal lymph node dissection. Pathological histology revealed sarcoma with epithelioid morphology and lymph node metastasis. Immunohistochemistry showed ALK (D5F3) and ALK1 proteins were strongly expressed. NGS and FISH detection confirmed the fusion of exon 7 of EWSR1 and exon 6 of CREM in sarcoma. Without ALK molecular changes was observed. Five months after the visit, lung imaging revealed multiple lung masses suggestive of tumor metastasis. Despite the current insufficiency in the theoretical foundation for the experimental diagnosis of ALK targeted therapy in this particular case, patients afflicted with severe anemia are unable to endure chemotherapy, thus opting for oral alectinib treatment. The results of a 21-month follow-up revealed that the patient's lung nodules exhibited a slight increase in size compared to their initial measurements, indicating a gradual growth pattern. The present findings suggest that alectinib exhibits ineffectiveness in the treatment of soft tissue sarcoma characterized by EWSR1-CREM fusion and abnormal ALK protein expression. Consequently, the exploration of novel targeted medications, such as pazopanib, is warranted.
Long-term Experience with AMS-700 CXR Inflatable Penile Prosthesis in High-risk Patients with Corporal Fibrosis
Authors: VanDyke Maia , Johnson Blake , Langford Brian , Cook Grayden , Franzen Bryce , Morey Allen 
Published: March 2024

Abstract

Despite the widespread use of narrow diameter inflatable penile prosthesis (IPP) cylinders in patients with corporal fibrosis, outcomes data is sparse. We evaluated patients who underwent IPP placement with AMS™ 700 controlled expansion restricted (CXR) cylinders from 2007-2021. Patient characteristics, device details, and surgical outcomes were assessed. A non-validated questionnaire was also distributed to patients to assess satisfaction. Among 982 IPPs placed over the study period at our institution, 49 (5.3%) used CXR cylinders. Indications for narrow cylinders: prior explant for infection (67.3%), ischemic priapism (16.3%), and idiopathic fibrosis (16.3%). Median corporal length was 19cm (IQR 17-21cm). Discordant intraoperative corporal measurements (24.5%) and rear tip extender lengths (26.5%) were common. Post-operative complications occurred in 8 patients (16.3%) and included 3 infections (6.1%), 2 cylinder herniations (4.1%), 2 mechanical failures (4.1%) and one case of glans necrosis (2.0%). Five of these (10.2%) required explantation, while 4 (8.2%) were managed with revision. Over the follow-up period, 73% of patients reported satisfaction with rigidity. Primary drivers of dissatisfaction were perceived loss of penile length and girth. The AMS™ 700 CXR is a useful tool for challenging corporal fibrosis cases and shows acceptable surgical outcomes with moderate patient acceptability.
Nutritional Status of Elderly Patients with Type 2 Diabetes Mellitus: Case of a Regional Hospital
Authors: Boli ANNE ONGMEB , OWONA Cedric TSALA , FEUTSEU Charly , Hadja Inna Astasselbe , DJEUGOUE Paulette , Manga Arnaud Ndi , Tabi Crista , Mambap Alex , Eugene Sobngwi 
Published: March 2024

Abstract
Introduction
There is a higher risk of occurrence of noncommunicable diseases such as hypertension and type 2 diabetes mellitus as age increases. Given that data on the burden of undernutrition among these patients are scarce in our context, we aimed to assess the nutritional status of elderly patients with type 2 diabetes mellitus followed at Bamenda Regional Hospital.
Methods: We conducted a cross-sectional study at the diabetic unit and the consultation unit of the hemodialysis center of the Bamenda Regional Hospital. The study population consisted of 146 outpatients aged 60 years and above, with type 2 diabetes mellitus attending the consultation from February 1st to May 31st, 2023 who gave their informed consent during our study period. Nutritional status was assessed using MNA-SF and GLIM criteria. Data were collected using a pretested questionnaire. Data were analyzed using the computer software SPSS version 26.
Results: The mean age was 68.7 years. Normal BMI was found in 35.6% (n=52) of participants whereas 1.4% (n=2) had a BMI below 18.5kg/m2. The prevalence of undernutrition in elderly patients with type 2 diabetes mellitus was 12.3% according to the MNA-SF and 15.1% according to the GLIM criteria. A poor fasting blood glucose status, a normal body mass index, waist circumference, and serum albumin levels summarized the clinical and biological presentation of the undernourished participants. There was a strong association between age above 70 years and undernutrition [OR 4.1(95% CI: 1.48-11.3)] but not with diabetes duration. An association between polypharmacy and undernutrition [OR 0.29 (95% CI: 0.12-0.74)] was also reported.
Conclusion: The prevalence of undernutrition in elderly patients with type 2 diabetes mellitus was 12.3% and 15.1% with respect to the screening tool used. (MNA-SF and the GLIM criteria). There was a four-fold increase in the risk of undernutrition in patients above 70 years.