bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the "shape-performance-control" integrated digital twin system for boom-type roadheaders
Authors: Zhang Jianzhuo , Wan Chuanxu , Wang Jie , Chen Ce , Wang Tao , Zhang Runfeng , Guo Hao 
Published: March 2024

AbstractThe boom-type roadheader plays a crucial role in coal mining. However, conducting the real-time monitoring of the mechanical performance and comprehensive adaptive cutting in the dynamic cutting process are challenging. To address these issues, a digital twin system that integrates the elements of “shape, performance, and control” for roadheaders is presented in this paper. The system comprises three components: physical space, service space, and twin space. The service space forms the core of the entire system. Within this space, twin models and control models are created using numerical simulation, artificial intelligence and multi-source data fusion technology. These models serve the purpose of predicting the roadheader’s mechanical performance and controlling the swing speed of the cutting arm. The physical space is built using technologies such as robot kinematics, electrical systems, hydraulic transmission, and other relevant techniques. This approach facilitates the transmission of multi-sensor data to twin models. The control model then manages the roadheader’s function based on the output signals from the control model. The twin space is constructed utilizing physical rendering engines, databases, and 3D modelling tools. This space visualizes and stores the movement, performance, and control parameters of the roadheader. The results demonstrate that the average absolute error between the measured data from the test’s three position strain gauges and the predicted data from the twin system is 10.38 MPa. Furthermore, the twin system achieves an average update interval of 0.34 s, allowing real-time stress monitoring of the structural components of the roadheader and preventing damage caused by overload. The proposed control model enables adaptive adjustment of the swing speed of the cutting arm in approximately 0.3 s. This improvement significantly enhances the adaptive cutting capabilities of roadheaders when dealing with complex coal and rock formations.
Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis
Authors: Shimada Fumie , Yoshimatsu Yusuke , Sujino Tomohisa , Fukuda Tomohiro , Aoki Yasuhiro , Hayashi Yukie , Tojo Anna , Kawaguchi Takaaki , Kiyohara Hiroki , Sugimoto Shinya , Nanki Kosaku , Mikami Yohei , Miyamoto Kentaro , Takabayashi Kaoru , Hosoe Naoki , Kato Motohiko , Ogata Haruhiko , Naganuma Makoto , Kanai Takanori 
Published: March 2024

AbstractIndigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis after induction therapy is unknown. Moreover, the clinical features of patients who relapsed within 52 weeks after the discontinuation of indigo naturalis are unclear. This study aimed to assess the clinical outcomes of patients with ulcerative colitis after discontinuation of indigo naturalis and to identify potential markers responsible for relapse. This single-center retrospective study investigated the follow-up of 72 patients who achieved a clinical response 8 weeks after indigo naturalis treatment. We observed relapse in patients with ulcerative colitis after the discontinuation of indigo naturalis. We analyzed the factors predicting long-term outcomes after discontinuation of indigo naturalis. Relapse was observed in 24%, 57%, and 71% of patients at 8, 26, and 52 weeks, respectively. There were no predictive markers in patients who relapsed within 52 weeks after the discontinuation of indigo naturalis. The ulcerative colitis relapse rate after indigo naturalis discontinuation was high. Follow-up treatment is required after the discontinuation of indigo naturalis in patients with ulcerative colitis.
Synthetic receptor scaffolds significantly affect the efficiency of cell fate signals
Authors: Umene Kirato , Kawahara Masahiro 
Published: March 2024

AbstractMimicry of receptor functions by designing synthetic receptors would be one of the recently hot research trends in cell engineering. While several types of synthetic receptors have been designed to induce desired cell fates in response to external stimuli, little is known about which receptor type signals more efficiently for inducing a certain cell fate. In this study, we compared the performance of three types of synthetic receptor scaffolds, i.e. myristoylated, cytosolic, and transmembrane types that signal through JAK-dependent phosphorylation of tyrosine motifs to transduce growth signaling. As a result, the phosphorylation levels of JAK and subsequent downstream signaling molecules were significantly maintained in the cytosolic type receptors, leading to more efficient cell growth than the other types. In contrast, the phosphorylation levels of JAK decreased in a motif-dependent manner in the transmembrane type receptors. Although various studies on receptor engineering based on domain or motif engineering have been reported, to our knowledge this study is the first to demonstrate that synthetic receptor scaffolds significantly affect the efficiency of cell fate signals. These findings are important for both receptor biology and receptor engineering, providing guidelines for rationally designing synthetic receptors that can transduce as efficient signaling as possible.
Fault-scale crustal structure across the Dunhua-Mishan fault (Tanlu northern segment) constrained from teleseismic P-wave receiver functions
Authors: Liu Qian , Lü Ziqiang , Zhang Guangwei , Lu Mingwen 
Published: March 2024

AbstractThe Dunhua-Mishan fault, located in the northern segment of the Tanlu fault zone, experienced multiple tectonic processes associated with the effects of the Pacific Plate subduction and the Indo-Asia collision. The high-resolution fault-scale structure is critical for understanding the fault evolution and potential fault damage. However, the well-defined deep structure of the Dunhua-Mishan fault is still unclear due to the lack of the dense seismic array. In this study, we construct a high-resolution P-wave receiver function imaging based on linear dense seismic array across the fault. Our results reveal the strong Moho depth variation across the Dunhua-Mishan fault zone. The slightly higher Vp/Vs ratio values within the fault zone indicate the presence of a small amount of mafic crust composition. Interestingly, the significant double positive Ps converted phases are observed within the fault zone, which may represent double Moho discontinuities. The double Moho structure may be related to multiple significant tectonic activities in the Tanlu northern segment. These newly observed structures provide new seismic constraints on the formation and evolution of the Tanlu fault zone and probably reflect that the lithospheric structure of the Dunhua-Mishan fault has been modified by a series of tectonic processes.
Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI)
Authors: Anderson Eric C. , DiPalazzo John , Lucas F. Lee , Hall Michael J. , Antov Andrey , Helbig Petra , Bourne Jennifer , Graham Leah , Gaitor Lory , Lu-Emerson Christine , Bradford Leslie S. , Inhorn Roger , Sinclair Sarah J. , Brooks Philip L. , Thomas Christian A. , Rasmussen Karen , Han Paul K. J. , Liu Edison T. , Rueter Jens 
Published: March 2024

AbstractGenomic tumor testing (GTT) is an emerging technology aimed at identifying variants in tumors that can be targeted with genomically matched drugs. Due to limited resources, rural patients receiving care in community oncology settings may be less likely to benefit from GTT. We analyzed GTT results and observational clinical outcomes data from patients enrolled in the Maine Cancer Genomics Initiative (MCGI), which provided access to GTTs; clinician educational resources; and genomic tumor boards in community practices in a predominantly rural state. 1603 adult cancer patients completed enrollment; 1258 had at least one potentially actionable variant identified. 206 (16.4%) patients received a total of 240 genome matched treatments, of those treatments, 64% were FDA-approved in the tumor type, 27% FDA-approved in a different tumor type and 9% were given on a clinical trial. Using Inverse Probability of Treatment Weighting to adjust for baseline characteristics, a Cox proportional hazards model demonstrated that patients who received genome matched treatment were 31% less likely to die within 1 year compared to those who did not receive genome matched treatment (HR: 0.69; 95% CI: 0.52–0.90; p-value: 0.006). Overall, GTT through this initiative resulted in levels of genome matched treatment that were similar to other initiatives, however, clinical trials represented a smaller share of treatments than previously reported, and "off-label" treatments represented a greater share. Although this was an observational study, we found evidence for a potential 1-year survival benefit for patients who received genome matched treatments. These findings suggest that when disseminated and implemented with a supportive infrastructure, GTT may benefit cancer patients in rural community oncology settings, with further work remaining on providing genome-matched clinical trials.
A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits
Authors: Zhu Yunqing , Zhuang Zhenhuang , Lv Jun , Sun Dianjianyi , Pei Pei , Yang Ling , Millwood Iona Y. , Walters Robin G. , Chen Yiping , Du Huaidong , Liu Fang , Stevens Rebecca , Chen Junshi , Chen Zhengming , Li Liming , Yu Canqing ,   On behalf of the China Kadoorie Biobank Collaborative Group
Published: March 2024

AbstractDespite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively. The novel loci highlighted the roles of structural abnormality of the upper airway and craniofacial region and dysfunction of metabolic and transport systems in the development of snoring. In the two-sample bi-directional Mendelian randomization analysis, higher body mass index, weight, and elevated blood pressure were causal for snoring, and a reverse causal effect was observed between snoring and diastolic blood pressure. Altogether, our results revealed the possible etiology of snoring in China and indicated that managing cardiometabolic health was essential to snoring prevention, and hypertension should be considered among snorers.
Crosstalk of cell death pathways unveils an autophagy-related gene AOC3 as a critical prognostic marker in colorectal cancer
Authors: Xu Hui , Cui Haiyang , Weng Siyuan , Zhang Yuyuan , Wang Libo , Xing Zhe , Han Xinwei , Liu Zaoqu 
Published: March 2024

AbstractThe intricate crosstalk of various cell death forms was recently implicated in cancers, laying a foundation for exploring the association between cell death and cancers. Recent evidence has demonstrated that biological networks outperform snapshot gene expression profiles at discovering promising biomarkers or heterogenous molecular subtypes across different cancer types. In order to investigate the behavioral patterns of cell death-related interaction perturbation in colorectal cancer (CRC), this study constructed the interaction-perturbation network with 11 cell death pathways and delineated four cell death network (CDN) derived heterogeneous subtypes (CDN1-4) with distinct molecular characteristics and clinical outcomes. Specifically, we identified a subtype (CDN4) endowed with high autophagy activity and the worst prognosis. Furthermore, AOC3 was identified as a potential autophagy-related biomarker, which demonstrated exceptional predictive performance for CDN4 and significant prognostic value. Overall, this study sheds light on the complex interplay of various cell death forms and reveals an autophagy-related gene AOC3 as a critical prognostic marker in CRC.
A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells
Authors: Lin Yuan , Wang Xue , Qin Yuhao , Wang Chengpan , Zhou Tang , Zhang Long , Su Lu , Ren Wenming , Liao Cheng 
Published: March 2024

AbstractThe occurrence of many autoimmune diseases takes root on the disrupted balance among Treg cells, Teff cells, etc. Low-dose interleukin-2 (IL-2) cytokine demonstrates promising clinical efficacy in the expansion of Treg cells and the treatment of autoimmune diseases. However, its clinical application is hindered by the small therapeutic index and short half-life. Previous studies have shown that non-covalent complex of human IL-2 and anti-IL-2 antibody biases cytokine activity towards Treg cells and extends IL-2’s half-life. The clinical translation of such complex is non-trivial. In this study, we discover an anti-human IL-2 antibody and engineer a covalently-linked single-agent fusion of human IL-2 and its antibody that selectively expands Treg cells and exhibits superior disease control activity in animal models of ulcerative colitis and systemic lupus erythematosus, with proper safety profile and good developability. These studies pave the road for its clinical development in diverse autoimmune diseases.
Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior
Authors: Kembro Jackelyn Melissa , Flesia Ana Georgina , Acosta-Rodríguez Victoria América , Takahashi Joseph S. , Nieto Paula Sofía 
Published: March 2024

AbstractAnimal behavior emerges from integration of many processes with different spatial and temporal scales. Dynamical behavioral patterns, including daily and ultradian rhythms and the dynamical microstructure of behavior (i.e., autocorrelations properties), can be differentially affected by external cues. Identifying these patterns is important for understanding how organisms adapt to their environment, yet unbiased methods to quantify dynamical changes over multiple temporal scales are lacking. Herein, we combine a wavelet approach with Detrended Fluctuation Analysis to identify behavioral patterns and evaluate changes over 42-days in mice subjected to different dietary restriction paradigms. We show that feeding restriction alters dynamical patterns: not only are daily rhythms modulated but also the presence, phase and/or strength of ~12h-rhythms, as well as the nature of autocorrelation properties of feed-intake and wheel running behaviors. These results highlight the underlying complexity of behavioral architecture and offer insights into the multi-scale impact of feeding habits on physiology.
Molecular mechanism of siderophore regulation by the Pseudomonas aeruginosa BfmRS two-component system in response to osmotic stress
Authors: Song Yingjie , Wu Xiyu , Li Ze , Ma Qin qin , Bao Rui 
Published: March 2024

AbstractPseudomonas aeruginosa, a common nosocomial pathogen, relies on siderophores to acquire iron, crucial for its survival in various environments and during host infections. However, understanding the molecular mechanisms of siderophore regulation remains incomplete. In this study, we found that the BfmRS two-component system, previously associated with biofilm formation and quorum sensing, is essential for siderophore regulation under high osmolality stress. Activated BfmR directly bound to the promoter regions of pvd, fpv, and femARI gene clusters, thereby activating their transcription and promoting siderophore production. Subsequent proteomic and phenotypic analyses confirmed that deletion of BfmRS reduces siderophore-related proteins and impairs bacterial survival in iron-deficient conditions. Furthermore, phylogenetic analysis demonstrated the high conservation of the BfmRS system across Pseudomonas species, functional evidences also indicated that BfmR homologues from Pseudomonas putida KT2440 and Pseudomonas sp. MRSN12121 could bind to the promoter regions of key siderophore genes and osmolality-mediated increases in siderophore production were observed. This work illuminates a novel signaling pathway for siderophore regulation and enhances our understanding of siderophore-mediated bacterial interactions and community establishment.
ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
Authors: Li Meng-Die , Lu Jiang-Wen , Zhang Fan , Lei Wen-Jia , Pan Fan , Lin Yi-Kai , Ling Li-Jun , Myatt Leslie , Wang Wang-Sheng , Sun Kang 
Published: March 2024

AbstractHyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown. Here, we reveal that versican (VCAN) is the major hyalectan in the amnion, where its cleavage increases at parturition with spontaneous rupture of membrane. We further reveal that ADAMTS4 is a crucial proteolytic enzyme for VCAN cleavage in the amnion. Inflammatory factors may enhance VCAN cleavage by inducing ADAMTS4 expression and inhibiting ADAMTS4 endocytosis in amnion fibroblasts. In turn, versikine, the VCAN cleavage product, induces inflammatory factors in amnion fibroblasts, thereby forming a feedforward loop between inflammation and VCAN degradation. Mouse studies show that intra-amniotic injection of ADAMTS4 induces preterm birth along with increased VCAN degradation and proinflammatory factors abundance in the fetal membranes. Conclusively, there is enhanced VCAN cleavage by ADAMTS4 in the amnion at parturition, which can be reenforced by inflammation.
Electromagnetic near-field mutual coupling suppression with active Janus sources
Authors: Xue Bo , Oyesina Kayode Adedotun , Wong Alex M. H. 
Published: March 2024

AbstractElectric dipoles and magnetic dipoles are the most fundamental particles in electromagnetic theory. Huygens and Janus sources, formed by the orthogonal combination of electric and magnetic dipoles, both show good directionality in the near field. Although the Huygens source has been widely used in antennas and metasurfaces, the applications of Janus source are heretofore limited. In this paper we report the physical construction of an active Janus source. Through full-wave simulations within the parallel plate waveguide (PPW) environment, we show that our source achieves the directional electromagnetic near-field and quasi-isotropic far-field requisite of the Janus source. Using this fact, we demonstrate that two active Janus and Huygens sources in close proximity (about 0.10 to 0.25 wavelengths) achieve a near 1000-fold reduced mutual coupling compared to electric dipole sources. Particularly, the simultaneous achievement of strong mutual coupling suppression and quasi-isotropic radiation make the Janus source an ideal candidate for consideration in future compact multi-input multi-output (MIMO) communication systems.
Modern coral range expansion off southeast Florida falls short of Late Holocene baseline
Authors: Modys Alexander B. , Oleinik Anton E. , Toth Lauren T. , Precht William F. , Mortlock Richard A. 
Published: March 2024

AbstractAs thermal stress and disease outbreaks decimate coral reefs throughout the tropics, there is growing evidence that higher latitude marine environments may provide crucial refuges for many at-risk, temperature-sensitive coral species. However, our understanding of how coral populations expand into new areas and sustain themselves over time is constrained by the limited scope of modern observations. Here, we provide geological insights into coral range expansions by reconstructing the composition of a Late Holocene-aged subfossil coral death assemblage on the southeast Florida reef tract and comparing it to modern reefs throughout the region. Our findings show that the Late Holocene coral assemblages were dominated by now critically endangered Acropora species between ~3500 and 1800 years before present, mirroring classic zonation patterns characteristic of healthy pre-1970s Caribbean reefs. In contrast, the modern reefs off southeast Florida are becoming increasingly dominated by stress-tolerant species like Porites astreoides and Siderastrea siderea despite modest expansions of Acropora cervicornis over the past several decades. Our results suggest that ongoing anthropogenic stressors, not present during the Late Holocene, are likely limiting the ability of modern higher latitude reefs in Florida to function as long-term climate refugia.
Intranasal oxytocin interacts with testosterone reactivity to modulate parochial altruism
Authors: Cherki Boaz R. , Winter Eyal , Mankuta David , Zerbib Shirli , Israel Salomon 
Published: March 2024

AbstractThe neuropeptide hormone oxytocin and the steroid hormone testosterone have received attention as modulators of behavior in the context of intergroup conflict. However, to date, their interactive effect has yet to be tested. Here, in a double-blind placebo-control design, 204 participants (102 female participants) self-administrated oxytocin or placebo and completed an experimental economic game modeling intergroup conflict. Salivary testosterone (n = 192) was measured throughout the task to assess endogenous reactivity. As a caveat, even at this sample size, our derived power to detect small effects for 2- and 3-way interactions was relatively low. For male participants, changes in testosterone predicted willingness to sacrifice investments for the betterment of the group. Intranasal administration of oxytocin strongly diminished this effect. In female participants, we found no credible evidence for association between changes in testosterone and investments, rather, oxytocin effects were independent of testosterone. This 3-way interaction was of medium to large effect size (Odds Ratio 5.11). Behavior was also affected by social cues such as signaling of ingroup and outgroup members. Our findings provide insights as to the biological processes underpinning parochial altruism and suggest an additional path for the dual influence of oxytocin and testosterone on human social behavior.
Securing the Internet of Medical Things with ECG‐based PUF encryption
Authors: Boi Biagio , Esposito Christian 
Published: March 2024

AbstractThe Internet of Things (IoT) is revolutionizing the healthcare industry by enhancing personalized patient care. However, the transmission of sensitive health data in IoT systems presents significant security and privacy challenges, further exacerbated by the difficulty of exploiting traditional protection means due to poor battery equipment and limited storage and computational capabilities of IoT devices. The authors analyze techniques applied in the medical context to encrypt sensible data and deal with the unique challenges of resource‐constrained devices. A technique that is facing increasing interest is the Physical Unclonable Function (PUF), where biometrics are implemented on integrated circuits' electric features. PUFs, however, demand special hardware, so in this work, instead of considering the physical device as a source of randomness, an ElectroCardioGram (ECG) can be taken into consideration to make a ‘virtual’ PUF. Such an mechanism leverages individual ECG signals to generate a cryptographic key for encrypting and decrypting data. Due to the poor stability of the ECG signal and the typical noise existing in the measurement process for such a signal, filtering and feature extraction techniques must be adopted. The proposed model considers the adoption of pre‐processing techniques in conjunction with a fuzzy extractor to add stability to the signal. Experiments were performed on a dataset containing ECG records gathered over 6 months, yielding good results in the short term and valuable outcomes in the long term, paving the way for adaptive PUF techniques in this context.