bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcome of multilayer flow modulator in aortic aneurysms
Authors: Pintaric Karlo , Boltezar Lucka , Umek Nejc , Kuhelj Dimitrij 
Published: April 2024

Abstract

Background
This retrospective study investigated the efficacy of endovascular treatment with multilayer flow modulators (MFMs) for treating aortic aneurysms in high-risk patients unsuitable for conventional treatments.

Patients and methods
Conducted from 2011 to 2019 at a single center, this retrospective observational study included 17 patients who underwent endovascular treatment with MFMs. These patients were selected based on their unsuitability for traditional surgical or endovascular procedures. The study involved meticulous pre-procedural planning, precise implantation of MFMs, and follow-up using CT angiography. The primary focus was on volumetric and flow volume changes in aneurysms, along with traditional diameter measurements. Moreover, the technical success and post-procedural complications were also registered.

Results
The technical success rate was 100%, and 30-day procedural complication rate was 17.6%. Post-treatment assessments revealed that 11 out of 17 patients showed a decrease in flow volume within the aneurysm sac, indicative of a favorable hemodynamic response. The median decrease in flow volume was 12 ml, with a median relative decrease of 8%. However, there was no consistent reduction in aneurysm size; most aneurysms demonstrated a median increase in volume for 46 ml and median increase in diameter for 18 mm.

Conclusions
While MFMs offer a potential alternative for high-risk aortic aneurysm patients, their effectiveness in preventing aneurysm expansion is limited. The results suggest that MFMs can provide a stable hemodynamic environment but do not reliably reduce aneurysm size. This underscores the need for ongoing vigilance and long-term monitoring in patients treated with this technology.
Unravelling the lung cancer diagnostic pathway: identifying gaps and opportunities for improvement
Authors: Marc Malovrh Mateja , Adamic Katja 
Published: April 2024

Abstract

Background
A fast and well-organized complex diagnostic process is important for better success in the treatment of lung cancer patients. The aim of our study was to reveal the gaps and inefficiencies in the diagnostic process and to suggest improvement strategies in a single tertiary centre in Slovenia.

Patients and methods
We employed a comprehensive approach to carefully dissect all the steps in the diagnostic journey for individuals suspected of having lung cancer. We gathered and analysed information from employees and patients involved in the process by dedicated questionnaires. Further, we analysed the patients’ data and calculated the diagnostic intervals for patients in two different periods.

Results
The major concerns among employees were stress and excessive administrative work. The important result of the visual journey and staff reports was the design of electronic diagnostic clinical pathway (eDCP), which could substantially increase safety and efficacy by diminishing the administrative burden of the employees. The patients were generally highly satisfied with diagnostic journey, but reported too long waiting times. By analysing two time periods, we revealed that diagnostic intervals exceeded the recommended timelines and got importantly shorter after two interventions - strengthening the diagnostic team and specially by purchase of additional PET-CT machine (the average time from general practitioner (GP) referral to the multidisciplinary treatment board (MDTB) decision was 50.8 [± 3.0] prior and 37.1 [± 2.3] days after the interventions).

Conclusions
The study illuminated opportunities for refining the diagnostic journey for lung cancer patients, underscoring the importance of both administrative and capacity-related enhancements.
Potentially fatal complications of new systemic anticancer therapies: pearls and pitfalls in their initial management
Authors: Kovac Milena Blaz , Seruga Bostjan 
Published: April 2024

Abstract

Background
Various types of immunotherapy (i.e. immune checkpoint inhibitors [ICIs], chimeric antigen receptor [CAR] T-cells and bispecific T-cell engagers [BiTEs]) and antibody drug conjugates (ADCs) have been used increasingly to treat solid cancers, lymphomas and leukaemias. Patients with serious complications of these therapies can be presented to physicians of different specialties. In this narrative review we discuss potentially fatal complications of new systemic anticancer therapies and some practical considerations for their diagnosis and initial treatment.

Results
Clinical presentation of toxicities of new anticancer therapies may be unpredictable and nonspecific. They can mimic other more common medical conditions such as infection or stroke. If not recognized and properly treated these toxicities can progress rapidly into life-threatening conditions. ICIs can cause immune-related inflammatory disorders of various organ systems (e.g. pneumonitis or colitis), and a cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) may develop after treatment with CAR T-cells or BiTEs. The cornerstones of management of these hyper-inflammatory disorders are supportive care and systemic immunosuppressive therapy. The latter should start as soon as symptoms are mild-moderate. Similarly, some severe toxicities of ADCs also require immunosuppressive therapy. A multidisciplinary team including an oncologist/haematologist and a corresponding organ-site specialist (e.g. gastroenterologist in the case of colitis) should be involved in the diagnosis and treatment of these toxicities.

Conclusions
Health professionals should be aware of potential serious complications of new systemic anticancer therapies. Early diagnosis and treatment with adequate supportive care and immunosuppressive therapy are crucial for the optimal outcome of patients with these complications.
Diallel crosses in Picea abies V. Can early testing predict long-term performance?
Authors: Solvin Thomas Mørtvedt , Skrøppa Tore , Steffenrem Arne 
Published: April 2024

Abstract
Genetic variation and performance of up to 40-year-old Norway spruce (Picea abies (L.) Karst.) families from half-diallel crosses made in natural populations where studied, and the results were compared with results from nursery test of seedlings (1-2 years from seed) and short-term farm-field tests at 6-10 years from seed. The diallel analyses revealed significant levels of additive genetic variance for growth and phenology traits. The non-additive genetic variance was generally small to moderate. Strong genetic correlations for growth performance were found between the short-term and long-term trials but not between the nursery and long-term trials. Similarly, genetic correlations for phenology traits were strong between short-term trials and long-term trials, whereas the nursery tests generally did not predict phenology at older age well. The findings indicate that early selection for growth and adaptive traits based on short-term trials is effective for improvement of long-term performance in field if the test site is not outside the normal range of deployment of the reproductive material.
Some Alternative Interpretations of Strongly Star Semi-Rothberger and Related Spaces
Authors: Sarkar Susmita , Bal Prasenjit 
Published: April 2024

Abstract
In this article, some under-appreciated characteristics of strongly star-Rothberger subsets are explored. Additionally, with the aid of the SSI property and MSSI property, semi-Rothberger and star semi-Rothberger spaces are represented by families of closed sets. Finally, several selection principle like attributes are produced that can reflect the previously mentioned sequential covering features in an inverted form.
Existence Result for a Stochastic Functional Differential System Driven by G-Brownian Motion with Infinite Delay
Authors: Chalabi El-Hacène , Mesbahi Salim , Ouaoua Amar 
Published: April 2024

Abstract
In this article, we are interested in the study of a class of stochastic functional differential systems driven by G-Brownian motion with infinite delay. We prove the existence and uniqueness of the solutions when two basic conditions are met: the linear growth condition and the Lipschitz condition.
Algebraic Cryptanalysis of Ascon Using MRHS Equations
Authors: Smičík Miloslav , Zajac Pavol 
Published: April 2024

Abstract
Ascon is a family of lightweight authenticated encryption and hashing algorithms, which is a finalist in the NIST Lightweight Cryptography competition. We study the Ascon algorithm from the perspective of algebraic cryptanalysis based on the MRHS representation of the cipher. We call such an approach an MRHS cryptanalysis.
We represent the system on the gate level (focusing on individual AND-gates) and the S-box level (basing MRHS equations on 5-bit S-boxes). We compare the results from the application of two custom MRHS solvers. The RZ solver is based on linear algebra and exhaustive search. The HC solver is based on adaptive bit-flipping with restarts.
We show that both the choice of the solver and the choice of the system representation influence the total complexity of the attack. On the other hand, these choices do not change the fundamental properties of the attack, such as scaling with the amount of information the attacker possesses. A similar assessment holds for using a scaled-down version of Ascon for the experiments. Our method can be used for the experimental evaluation of cipher designs against algebraic attacks.
Niche Heritage Tourism in Stingray Island: The Case of Japanese Defense Heritage in Indonesia
Authors: Chairy  , Prayoga Tasya Zahwa , Rahmiati Filda , Goenadhi Felix , Bakri Mohammed Hariri Bin 
Published: April 2024

Objective: The purpose of this study is to analyze the competitiveness of Morotai Island, located in North Maluku, in terms of tourism development potential.

Theoretical Framework: Tourism, defined as the movement of people to increase employment opportunities, local community economies, international trade, export revenue, foreign exchange earnings and investment, is influenced by a variety of social, cultural, and economic variables. Therefore, heritage sites and historic monuments are critical to urban development because they promote a sense of community among citizens while also emphasizing local identity and location.

Method: Empirical research was carried out utilizing an inductive methodology using a variety of primary and secondary data sources.

Results and Discussion: Results indicate that to further strengthen the community and further its tourism and regeneration aims, it could be beneficial for the autonomous organization organizing and overseeing social and cultural events and activities. Furthemore, to develop a range of tourism supporting services, the inventiveness of the region’s tourism entrepreneurs also require training in the early stages of region’s development.

Research Implications: The study implicates an overall belief that improving Morotai's urban and economic landscape through tourism will either keep locals in the area or discourage them from leaving in pursuit of better opportunities and a higher standard of living.

Originality/Value: This study contributes to the community heritage-based tourism as a tool of diversifying its local economic structure. This research precisely to recognize historic-heritage area in as a strategic instrument to develop rural areas.
Determinants of Academic Satisfaction: An Empirical Analysis of a Brazilian National Institute
Authors: Walter Cicero Eduardo , Vasconcelos Stefhany Amorim , Ursino Júnior Odias C , Franco Maxwell Klinger Assunção , Au-Yong-Oliveira Manuel , Veloso Cláudia Miranda 
Published: April 2024

Objective: The present investigation aims to identify the explanatory factors for academic satisfaction, as well as the influence that the identified factors have on the degree of academic satisfaction in its global context and on the chances of the institution's recommendation to friends and family.

Method: The investigation was conducted with a sample of 290 students from the Federal Institute of Education, Science, and Technology of Piauí (FIEPI-Campus Oeiras). The instrument used for data collection was a questionnaire. The statistical techniques used were of a descriptive, exploratory, and multivariate nature for the treatment, analysis, and validation of the results.

Results and Discussion: The results indicate that Academic Satisfaction is determined by the factors (1) Teaching Environment and (2) Structural Environment and that there is a significant decrease in Academic Satisfaction when students move from the group from High School to Higher Education due to the determinants satisfaction.

Research Implications: The development of strategies for the maintenance and attraction of new students by FIEPI-Campus Oeiras and other educational institutions must be based on academic satisfaction considering their specificities, namely, concerning the different perceptions and expectations generated by students about educational services.

Originality/Value: The relevance of this investigation is based on the fact that the measurement of student satisfaction by a given educational institution becomes essential for it to understand the perception of its students about its products and services, enabling the identification of new ways of generating satisfaction and loyalty.
Encouraging Religion and Sustainable Tourism as a Conception of Indonesian Halal Tourism Development
Authors: Danarta Agung , Pradana Mahatva Yoga Adi , Abror Indal , Yahya Nur Edi Praba Susilo 
Published: April 2024

Objective: This study aims to explore and analyse the development of halal tourism in Indonesia, focusing on the synergy between religion and sustainable tourism. The aim is to understand how religion and sustainable tourism principles can support the growth of halal tourism and its potential economic and social benefits. Theoretical Framework: The study draws on halal tourism, religion, and sustainable tourism. It examines how religion can provide a moral and ethical foundation for halal tourism practices and how sustainable tourism principles, including nature and cultural conservation, can be integrated into the development of halal tourism. Method: Qualitative methods are employed in this study, including interviews and observations. Informants from religious institutions, tourism organisations, and local communities are selected to gather insights and perspectives on the development of halal tourism in Indonesia. Results and Conclusion: The study's findings highlight the importance of the synergy between religion and sustainable tourism in the development of halal tourism in Indonesia. Religion provides guidance and direction for halal practices. The development of halal tourism based on this concept can bring economic opportunities, improve the quality of tourism services, and strengthen Indonesia's position as a leading halal tourism destination. Implications: The study's findings affect policymakers, tourism organizations, and local communities. They emphasise the need for supportive policies and collaborations to promote and implement sustainable halal tourism practices. Novelty: This study contributes to the existing literature on halal tourism by examining the synergy between religion and sustainable tourism in the context of Indonesia.
Sociology of Totems, Myths, and Tawhid: Exploring the Interplay Between Symbolism and Theology with Critical Analysis of Theological or Mythical Stage of August Comte’s Law of Three Stages
Authors: Sahimi Mohd Shafiq , Mir Sajad Ahmad , Kirin Arwansyah , Jaes Lutfan , Said Amirul Hakim Mad 
Published: April 2024

Introduction: Totems and myths, integral components of social, cultural, and religious expression, carry profound symbolic meanings within diverse societies. This paper investigates the interplay between these symbolic elements and Islamic theology, exploring how Islamic communities respond to the presence of symbols and symbolism. The paper presents a critical analysis of theological stage of August Comte’s law of three stages.

Objectives: The research objectives of the present paper aim to examine the prevalence of totems and myths in various societies and their negative impact in terms of theology, sociology, and identity formation. It will investigate the theological responses of Islam to the incorporation of totems and myths with a critical analysis of theological stage of August Comte’s law of three stages philosophically known as Positive Philosophy. Explore the implications of the interplay between totems, myths and Islamic theology on religious identity and belief system.

Methods: The present work is qualitative in nature and hence uses qualitative methodology.

Results and Conclusion: The findings of the paper suggest that Totemic and Mythical thinking must be dealt with a serious and sensitive approach to protect the fabric of Muslim society under the core teachings of Tawhid. Understanding the sociological implications of the symbolic systems, advocated by Islam, provides valuable insights into the intricate diversity of human culture, belief systems, and social organization. As societies continue to evolve, it becomes imperative to navigate the delicate balance between preserving cultural heritage, acknowledging diversity, and upholding the principles of justice and equality.

Originality/Value: the research presents a unique and original perspective on the intersection of sociology, symbolism, and theology. In essence, it delves into the intricate relationship between cultural symbols, religious beliefs, and social structures. What sets this paper apart is its innovative approach to studying the role of totems and myths within the framework of Tawhid, the Islamic concept of the oneness of God. By examining how totems and myths function within different cultural contexts and their implications for theological understanding, the paper offers fresh insights into the dynamics of religious symbolism.
What Will Be the Future of Zeropay, A Strategic Fintech Policy of Seoul Metropolitan Government
Authors: Cho June-Suh 
Published: April 2024

Objective: This study investigates the various perspectives on the perceived failure of government-led financial policy, particularly ZeroPay. We aim to propose strategies to lead ZeroPay to a successful market position by understanding the reasons behind this perception.

Theoretical Framework: This paper is based on the theory of citizen participation in e-government and discusses the ZeroPay policy and citizen participation.

Method: By comparing and analyzing the issues at the start of the policy and those that arose over the past five years, problems are identified, and solutions are derived. This paper finds out why ZeroPay has produced such results and why people think it is a failure, and discusses how to lead ZeroPay in the market successfully.

Results and Discussion: The biggest problems with ZeroPay are the inconvenience of payment methods, lack of credit card benefits, and lack of participation by small business owners and citizens. For the service to be successful, it is necessary to attract sustainable interest and participation from citizens and small business owners and cooperate with financial institutions and companies.

Research Implications: The government-led payment service has been unable to overcome the limitations raised when it was launched. Participating required much work for citizens and small business owners. For the service's success, the active participation of citizens, small business owners, and the private sector is necessary.

Originality/Value: This paper discusses the importance of citizen participation in SGM cases. We discuss whether cooperation with the private sector and active participation of citizens, rather than government-led, are essential for success.
De la muerte inexorable a la muerte escogida
Authors: Díaz Amado Eduardo 
Published: April 2024

La apertura de la primera unidad de cuidados intensivos colombiana en el Hospital San Juan de Dios de Bogotá, a principios de la década de 1970, fue un gran paso para el avance de la medicina en Colombia, y un escenario que reveló la necesidad de pensar el uso adecuado de la tecnología en el campo médico y en situaciones de cuidado crítico. Luego, la llegada en 1979 de la Fundación Pro-Derecho a Morir Dignamente –inicialmente Fundación Solidaridad Humanitaria-, que introdujo el primer documento de voluntad anticipada en el país, abrió un espacio en la sociedad para reflexionar sobre los límites de la medicina en la atención al final de la vida.
Había una preocupación, como en muchos otros lugares del mundo, por la deshumanización del morir, es decir, porque las personas cada vez más morían en el espacio frío y controlado del hospital, lejos de sus seres queridos, y sometidos a los dictámenes de una medicina altamente tecnologizada pero cada vez menos cercana a los deseos de los pacientes.
Para el sacerdote jesuita Alfonso Llano Escobar, uno de los pioneros de la bioética en Colombia, principal cuestión bioética en Colombia en la década de 1980 era la prolongación de la vida de los pacientes, gracias al poder de la medicina. Citaba el incremento en la cantidad de eventos académicos dedicados a discutir esta cuestión en aquella época. Para Llano Escobar era evidente que el enorme desarrollo de la tecnología médica había convertido en un problema el morir en estos tiempos. La medicalización de la vida y de la muerte avanzaban a pasos agigantados, lo que estaba relacionado con la deshumanización que se experimentaba en las instituciones de salud.
Surgió entonces la pregunta sobre cómo evitar el sufrimiento innecesario que traía la prolongación de la vida en pacientes terminales por el uso sin límites de la tecnología y porque los médicos suelen ser formados para hacer y hacer, pero no para pensar, cuándo detenerse o reorientar sus esfuerzos terapéuticos. Un problema que sigue presentándose aún hoy, a más de 30 años de haberse iniciado estas reflexiones en Colombia
A declining trend of hepatitis A and hepatitis E at tertiary care hospital in South Gujarat
Authors: Gandhi Twinkle Nareshchandra , Patel Swati Sugnesh , Chaudhary Apurva , Nakrani Kalpesh 
Published: April 2024

Objectives:
Hepatitis A virus (HAV) and Hepatitis E virus (HEV) both are spread through the fecal-oral route and cause acute viral hepatitis (AVH) and pose a major public health problem in India. This study was done to find out the proportion of positivity of HAV and HEV in patients with AVH and its seasonal trend.

Materials and Methods:
A retrospective study was carried out at Surat Municipal Institute of Medical Education and Research Medical College, Department of Microbiology, Surat, Gujarat. Result of 3615 blood samples of suspected AVH patients of the past 5 years (January 2018–December 2022) were taken from hospital data records. The enzyme-linked immunosorbent assay method was used to test serum samples for immunoglobulin M (IgM) HAV and IgM HEV antibodies for HAV and HEV, respectively. All samples were evaluated for liver function as well.

Results:
The positivity of HAV and HEV was 15.13% and 10.26%, respectively. The coinfection rate was 2.07%. HAV and HEV both affected males more than females. Among pregnant females, HEV infection had more positivity (6.77%) than HAV, which had 1.08% positivity. HAV and HEV infections had a seasonal trend, with the highest infection rate in the monsoon.

Conclusion:
The declining trend of cases of HAV and HEV was found in Surat city of south Gujarat which indicates increased awareness about hepatitis among people and better public health management by the civic authorities.