bluuebunny/crossref_metadata_2025_split huggingface dataset:
MERAM İLÇESİ ŞÜKRAN MAHALLESİNDEKİ RUM EMVAL-İ METRUKESİ (KONYA 1924)
Authors: KURTULGAN Kürşat 
Published: March 2024

Göç esnasında daha çok ticaret ile zenginleşmiş olan gayrimüslimler yanlarında değerli eşyalarını götürebilmişlerdir. Fakat taşınmaz mallarını ise götürme imkânları olmadığı için geride bırakmak zorunda kalmışlardır. Bu emval-i metrukelerin tamamı gelen mübadil, muhacir veya mültecilere verilmiştir. Gidenler için yürek acısı olan mahzun binalar, gelenler için ise başlarını sokacak bir ev ve geleceğe umutla bakabilme araçları olarak sevinç ve neşe kaynakları olmuşlardır. Mübadele antlaşması çerçevesinde tasfiye çalışmaları yapılırken geride bırakılan emval-i metrukelerin tespiti yapılmış ve kayıtlar defterlere işlenmiştir. Mübadele çerçevesinde tasfiye çalışmaları yapılmış ve bu çerçevede tespitleri yapılan bu malların bedelleri karşılıklı olarak ödenmiştir.
Araştırmamız, söz konusu çalışmalar yapılırken Konya merkezde bulunan emval-i metrukelerin işlendiği bir defter çerçevesinde şekillenmiştir. Defterde bulundukları mahaller, hane numaraları ve özellikleri en ince ayrıntılarına kadar kayıt altına alınmıştır. Defterlerde bulunan her türlü bilgi ve kayıt oluşturulan excel dosyalarına mahalle bazında işlenmiş ve değerlendirilmiştir. Bu deftere göre haneler başta olmak üzere dükkânlar, hanlar, fabrikalar, işyerleri, tarlalar, bağlar, arsa ve bahçeler tek tek tespit edilmiştir. Tespiti yapılan bu emval-i metrukeler bulundukları mahaller itibariyle son derece kıymetli değerlidir. Ayrıca şehir genelinde gidenlerin kullanımında olan bazı tesisler hakkında da burada bilgiler verilmiştir.
RADYO’DA BİR HİKÂYE: YENİDEN YAZIM PENCERESİNDEN KEREM İLE ASLI’YA BİR BAKIŞ
Authors: SAYGILI SAVAŞ Yeliz , BEKKİ Salahaddin 
Published: March 2024

Türk halk hikâyeleri içerisinde çok bilinen, sevilen ve anlatılan bir hikâye olarak karşımıza çıkan Kerem ile Aslı hem Anadolu’da hem de Türk boyları arasında büyük bir ilgi görerek geniş bir sahada yayılma imkânı bulmuş ve tanınmıştır. El yazması, taş baskı, matbu, sözlü pek çok metni bulunan hikâyenin, teknolojinin gelişmesi ile beraber elektronik kültür ortamında var olan yeniden yazılmış metin örneklerine de rastlanmaktadır. Öyle ki gelenekselin sunumunda büyük bir paya sahip olan medya sayesinde günümüz okuyucusu/izleyicisi/dinleyicisi metinle çok farklı platformlarda bir araya gelerek çeşitli tercihlerde bulunur. Muhakkak ki bu tercihlerden bir tanesi de özellikle 1940’lardan sonra geleneğin şekillenmesinde önemli bir dinamik olarak bahsedebileceğimiz radyodur. Bu bağlamda birçok kez yeniden yazım çalışmalarıyla karşımıza çıkan Kerem ile Aslı hikâyesinin radyo özelinde metinlerarası ilişkiler cephesinden değerlendirilmesi ve bu doğrultuda biçimsel ve anlamsal dönüşümlerin ortaya konması oldukça önemlidir.
Alt metin olarak hikâyenin daha önce neşredilmemiş bir nüshası üzerine çalışma yaparak hikâyeyi yeni Türk harflerine aktaran Özkan Daşdemir’in “Kerem ile Aslı Hikâyesi California Üniversitesi Nüshası” başlıklı eserindeki metin kullanılmıştır. Ana metinler ise Türkiye Radyo Televizyon Kurumu (TRT) arşivinden temin edilerek dört başlıkta sınıflandırılan Kerem ile Aslı hikâyesinin radyo metinlerinden seçilmiştir. Bu çalışmada, seçilen alt metin ve ana metinler çerçevesinde biçimsel ve anlamsal temelde gerçekleşen dönüşümler, aktarılan örnekler üzerinden irdelenmiştir.
Effects of botulinum neurotoxin on regularity of head oscillations in cervical dystonia
Authors: Agharazi Hanieh , Jinnah H. A. , Zee David S. , Shaikh Aasef G. 
Published: March 2024

Introduction: This study explores the effects of botulinum neurotoxin (BoNT) on the relationship between dystonia and tremor, specifically focusing on cervical dystonia (CD) and its connection to head tremor.Methods: Fourteen CD patients were recruited; eight (57%) with clinically observable head oscillations were included in further analysis. A high-resolution magnetic search coil system precisely measured head movements, addressing two questions: 1) BoNT’s effects on head movement amplitude, frequency, and regularity, and 2) BoNT’s influence on the relationship between head position and head oscillations. For the first question, temporal head position measurements of three patients were analyzed before and after BoNT injection. The second question examined the effects of BoNT injections on the dependence of the oscillations on the position of the head.Results: Three distinct trends were observed: shifts from regular to irregular oscillations, transitions from irregular to regular oscillations, and an absence of change. Poincaré analysis revealed that BoNT induced changes in regularity, aligning oscillations closer to a consistent “set point” of regularity. BoNT injections reduced head oscillation amplitude, particularly in head orientations linked to high-intensity pre-injection oscillations. Oscillation frequency decreased in most cases, and overall variance in the amplitude of head position decreased post-injection.Discussion: These findings illuminate the complexity of CD but also suggest therapeutic potential for BoNT. They show that co-existing mechanisms contribute to regular and irregular head oscillations in CD, which involve proprioception and central structures like the cerebellum and basal ganglia. These insights advocate for personalized treatment to optimize outcomes that is based on individual head oscillation characteristics.
Implications of O-glycan modifications in the hinge region of a plant-produced SARS-CoV-2-IgA antibody on functionality
Authors: Uetz Pia , Göritzer Kathrin , Vergara Emil , Melnik Stanislav , Grünwald-Gruber Clemens , Figl Rudolf , Deghmane Ala-Eddine , Groppelli Elisabetta , Reljic Rajko , Ma Julian K.-C. , Stöger Eva , Strasser Richard 
Published: March 2024

Introduction: Prolyl-4-hydroxylases (P4H) catalyse the irreversible conversion of proline to hydroxyproline, constituting a common posttranslational modification of proteins found in humans, plants, and microbes. Hydroxyproline residues can be further modified in plants to yield glycoproteins containing characteristic O-glycans. It is currently unknown how these plant endogenous modifications impact protein functionality and they cause considerable concerns for the recombinant production of therapeutic proteins in plants. In this study, we carried out host engineering to generate a therapeutic glycoprotein largely devoid of plant-endogenous O-glycans for functional characterization.Methods: Genome editing was used to inactivate two genes coding for enzymes of the P4H10 subfamily in the widely used expression host Nicotiana benthamiana. Using glycoengineering in plants and expression in human HEK293 cells we generated four variants of a potent, SARS-CoV-2 neutralizing antibody, COVA2-15 IgA1. The variants that differed in the number of modified proline residues and O-glycan compositions of their hinge region were assessed regarding their physicochemical properties and functionality.Results: We found that plant endogenous O-glycan formation was strongly reduced on IgA1 when transiently expressed in the P4H10 double mutant N. benthamiana plant line. The IgA1 glycoforms displayed differences in proteolytic stability and minor differences in receptor binding thus highlighting the importance of O-glycosylation in the hinge region of human IgA1.Discussion: This work reports the successful protein O-glycan engineering of an important plant host for recombinant protein expression. While the complete removal of endogenous hydroxyproline residues from the hinge region of plant-produced IgA1 is yet to be achieved, our engineered line is suitable for structure-function studies of O-glycosylated recombinant glycoproteins produced in plants.
Robotic-assisted anatomic anterior cruciate ligament reconstruction: a comparative analysis of modified transtibial and anteromedial portal techniques in cadaveric knees
Authors: Zhang Ling , Lin Jinpeng , Zhao Xuan , Liu Mingwei , Hou Yao , Zhang Yu , Zhao Jinzhong , Wang Shaobai 
Published: March 2024

Introduction: This study employed surgical robot to perform anatomic single-bundle reconstruction using the modified transtibial (TT) technique and anteromedial (AM) portal technique. The purpose was to directly compare tunnel and graft characteristics of the two techniques.Methods: Eight cadaveric knees without ligament injury were used in the study. The modified TT and AM portal technique were both conducted under surgical robotic system. Postoperative data acquisition of the tunnel and graft characteristics included tibial tunnel position, tunnel angle, tunnel length and femoral tunnel-graft angle.Results: The mean tibial tunnel length of the modified TT technique was significantly shorter than in the AM portal technique (p &lt; 0.001). The mean length of the femoral tunnel was significantly longer for the modified TT technique than for the AM portal technique (p &lt; 0.001). The mean coronal angle of the tibial tunnel was significantly lower for the modified TT technique than for the AM portal technique (p &lt; 0.001). The mean coronal angle of the femoral tunnel was significantly lower for the AM portal technique than for the modified TT technique (p &lt; 0.001). The AM portal technique resulted in a graft bending angle that was significantly more angulated in the coronal (p &lt; 0.001) and the sagittal planes (p &lt; 0.001) compared with the modified TT technique.Discussion: Comparison of the preoperative planning and postoperative femoral tunnel positions showed that the mean difference of the tunnel position was 1.8 ± 0.4 mm. It suggested that the surgical navigation robot could make predictable tunnel position with high accuracy. The findings may support that the modified TT technique has benefits on femoral tunnel length and obliquity compared with AM portal technique. The modified TT technique showed a larger femoral tunnel angle in the coronal plane than the AM portal technique. Compared with the modified TT technique, the more horizontal trajectory of the femoral tunnel in the AM portal technique creates a shorter femoral tunnel length and a more acute graft bending angle.
Feature discrimination learning transfers to noisy displays in complex stimuli
Authors: Azulai Orly , Shalev Lilach , Mevorach Carmel 
Published: March 2024

IntroductionPerception under noisy conditions requires not only feature identification but also a process whereby target features are selected and noise is filtered out (e.g., when identifying an animal hiding in the savannah). Interestingly, previous perceptual learning studies demonstrated the utility of training feature representation (without noise) for improving discrimination under noisy conditions. Furthermore, learning to filter out noise also appears to transfer to other perceptual task under similar noisy conditions. However, such learning transfer effects were thus far demonstrated predominantly in simple stimuli. Here we sought to explore whether similar learning transfer can be observed with complex real-world stimuli.MethodsWe assessed the feature-to-noise transfer effect by using complex stimuli of human faces. We first examined participants' performance on a face-noise task following either training in the same task, or in a different face-feature task. Second, we assessed the transfer effect across different noise tasks defined by stimulus complexity, simple stimuli (Gabor) and complex stimuli (faces).ResultsWe found a clear learning transfer effect in the face-noise task following learning of face features. In contrast, we did not find transfer effect across the different noise tasks (from Gabor-noise to face-noise).ConclusionThese results extend previous findings regarding transfer of feature learning to noisy conditions using real-life stimuli.
Advanced hemodynamics for prognostication in heart failure: the pursuit of the patient-specific tipping point
Authors: Grinstein Jonathan 
Published: March 2024

BackgroundObjective tools to define the optimal time for referral for advanced therapies and to help guide escalation and de-escalation of support can improve management decisions and outcomes for patients with advanced heart failure. The current parameters have variable prognostic potential depending on the patient population being studied and often have arbitrary thresholds.MethodsHere, a mathematical and physiological framework to define the patient-specific tipping point of myocardial energetics is defined. A novel hemodynamic parameter known as the myocardial performance score (MPS), a marker of power and efficiency, is introduced that allows for the objective assessment of the physiological tipping point. The performance of the MPS and other advanced hemodynamic parameters including aortic pulsatility index (API) and cardiac power output (CPO) in predicting myocardial energetics and the overall myocardial performance was evaluated using a validated computer simulation model of heart failure (Harvi) as well as a proof-of-concept clinical validation using a cohort of the Society for Cardiovascular Angiography and Interventions (SCAI) Stage C cardiogenic shock patients.ResultsApproximately 1010 discrete heart failure scenarios were modeled. API strongly correlated with the left ventricular coupling ratio (R2 = 0.81) and the strength of association became even stronger under loaded conditions where pulmonary capillary wedge pressure (PCWP) was &gt;20 mmHg (R2 = 0.94). Under loaded conditions, there is a strong logarithmic relationship between MPS and mechanical efficiency (R2 = 0.93) with a precipitous rise in potential energy (PE) and drop in mechanical efficiency with an MPS &lt;0.5. An MPS &lt;0.5 was able to predict a CPO &lt;0.6 W and coupling ratio of &lt;0.7 with sensitivity (Sn) of 87%, specificity (Sp) of 91%, positive predictive value of 81%, and negative predictive value of 94%. In a cohort of 224 patients with SCAI Stage C shock requiring milrinone initiation, a baseline MPS score of &lt;0.5 was associated with a 35% event rate of the composite endpoint of death, left ventricular assist device, or transplant at 30 days compared with 3% for those with an MPS &gt;1 (p &lt; 0.001). Patients who were able to augment their MPS to &gt;1 after milrinone infusion had a lower event rate than those with insufficient reserve (40% vs. 16%, p = 0.01).ConclusionsThe MPS, which defines the patient-specific power-to-efficiency ratio and is inversely proportional to PE, represents an objective assessment of the myocardial energetic state of a patient and can be used to define the physiological tipping point for patients with advanced heart failure.
Esophageal cancer detection via non-contrast CT and deep learning
Authors: Lin Chong , Guo Yi , Huang Xu , Rao Shengxiang , Zhou Jianjun 
Published: March 2024

BackgroundEsophageal cancer is the seventh most frequently diagnosed cancer with a high mortality rate and the sixth leading cause of cancer deaths in the world. Early detection of esophageal cancer is very vital for the patients. Traditionally, contrast computed tomography (CT) was used to detect esophageal carcinomas, but with the development of deep learning (DL) technology, it may now be possible for non-contrast CT to detect esophageal carcinomas. In this study, we aimed to establish a DL-based diagnostic system to stage esophageal cancer from non-contrast chest CT images.MethodsIn this retrospective dual-center study, we included 397 primary esophageal cancer patients with pathologically confirmed non-contrast chest CT images, as well as 250 healthy individuals without esophageal tumors, confirmed through endoscopic examination. The images of these participants were treated as the training data. Additionally, images from 100 esophageal cancer patients and 100 healthy individuals were enrolled for model validation. The esophagus segmentation was performed using the no-new-Net (nnU-Net) model; based on the segmentation result and feature extraction, a decision tree was employed to classify whether cancer is present or not. We compared the diagnostic efficacy of the DL-based method with the performance of radiologists with various levels of experience. Meanwhile, a diagnostic performance comparison of radiologists with and without the aid of the DL-based method was also conducted.ResultsIn this study, the DL-based method demonstrated a high level of diagnostic efficacy in the detection of esophageal cancer, with a performance of AUC of 0.890, sensitivity of 0.900, specificity of 0.880, accuracy of 0.882, and F-score of 0.891. Furthermore, the incorporation of the DL-based method resulted in a significant improvement of the AUC values w.r.t. of three radiologists from 0.855/0.820/0.930 to 0.910/0.955/0.965 (p = 0.0004/&lt;0.0001/0.0068, with DeLong’s test).ConclusionThe DL-based method shows a satisfactory performance of sensitivity and specificity for detecting esophageal cancers from non-contrast chest CT images. With the aid of the DL-based method, radiologists can attain better diagnostic workup for esophageal cancer and minimize the chance of missing esophageal cancers in reading the CT scans acquired for health check-up purposes.
Antimicrobial resistance and genomic investigation of Salmonella isolated from retail foods in Guizhou, China
Authors: Zhou Li , Ye Qian , Zhou Qian , Wang Jian , Li Guanqiao , Xiang Jingshu , Huang Jingyu , Zhao Yuanyuan , Zheng Tianli , Zuo Haojiang , Li Shijun 
Published: March 2024

IntroductionSalmonella is a major foodborne pathogen worldwide that causes severe morbidity and mortality. It is mainly caused by consuming contaminated food, with retail food considered the primary source.MethodsIn Guizhou, China, 102 Salmonella strains isolated from 2016 to 2021 underwent phenotypic antimicrobial resistance testing and whole-genome sequencing (WGS) to understand Salmonella diversity, including serotypes, sequencing types (STs), antimicrobial genes, virulence genes, plasmid types, multi-locus sequence types (MLST), and core genome MLST (cgMLST).Results and discussionS.Typhimurium was the dominant serotype, and O:4(B) was the leading serogroup. The most prevalent genotype was ST40. Phenotypic antimicrobial resistance identified 66.7% of the sampled isolates as multi-drug resistant (MDR). S.Enteritidis (n = 7), S.Typhimurium (n = 1), S.Indiana (n = 1), S.Kentucky (n = 1), S.Uganda (n = 1), all of which were MDR, were resistant to Colistin. Resistance rates varied significantly across different strains and food types, particularly meat products exhibiting higher resistance. Notably, significant increases in resistance were observed from 2016 to 2021 for the following: ≥ 1 resistant (P = 0.001), MDR (P = 0.001), ampicillin (P = 0.001), tetracycline (P &lt; 0.001), chloramphenicol (P = 0.030), and trimethoprim/sulfamethoxazole (P = 0.003). The marked escalation in drug resistance over the recent years, coupled with the varying resistance rates among food sources, underscores the growing public health concern. Our findings highlight the need for a coordinated approach to effectively monitor and respond to Salmonella infections in Guizhou, China.
The proteome of bacterial membrane vesicles in Escherichia coli—a time course comparison study in two different media
Authors: Yu Mia S. C. , Chiang Dapi Menglin , Reithmair Marlene , Meidert Agnes , Brandes Florian , Schelling Gustav , Ludwig Christina , Meng Chen , Kirchner Benedikt , Zenner Christian , Muller Laurent , Pfaffl Michael W. 
Published: March 2024

IntroductionBacteria inhabit the in- and outside of the human body, such as skin, gut or the oral cavity where they play an innoxious, beneficial or even pathogenic role. It is well known that bacteria can secrete membrane vesicles (MVs) like eukaryotic cells with extracellular vesicles (EVs). Several studies indicate that bacterial membrane vesicles (bMVs) play a crucial role in microbiome-host interactions. However, the composition of such bMVs and their functionality under different culture conditions are still largely unknown.MethodsTo gain a better insight into bMVs, we investigated the composition and functionality of E. coli (DSM 105380) bMVs from the culture media Lysogeny broth (LB) and RPMI 1640 throughout the different phases of growth (lag-, log- and stationary-phase). bMVs from three time points (8 h, 54 h, and 168 h) and two media (LB and RPMI 1640) were isolated by ultracentrifugation and analyzed using nanoparticle tracking analysis (NTA), cryogenic electron microscopy (Cryo-EM), conventional transmission electron microscopy (TEM) and mass spectrometry-based proteomics (LC–MS/MS). Furthermore, we examined pro-inflammatory cytokines IL-1β and IL-8 in the human monocyte cell line THP-1 upon bMV treatment.ResultsParticle numbers increased with inoculation periods. The bMV morphologies in Cryo-EM/TEM were similar at each time point and condition. Using proteomics, we identified 140 proteins, such as the common bMV markers OmpA and GroEL, present in bMVs isolated from both media and at all time points. Additionally, we were able to detect growth-condition-specific proteins. Treatment of THP-1 cells with bMVs of all six groups lead to significantly high IL-1β and IL-8 expressions.ConclusionOur study showed that the choice of medium and the duration of culturing significantly influence both E. coli bMV numbers and protein composition. Our TEM/Cryo-EM results demonstrated the presence of intact E. coli bMVs. Common E. coli proteins, including OmpA, GroEL, and ribosome proteins, can consistently be identified across all six tested growth conditions. Furthermore, our functional assays imply that bMVs isolated from the six groups retain their function and result in comparable cytokine induction.
A scientometric review of the growing trends in transcranial alternating current stimulation (tACS)
Authors: Liu Yuanli , Luo Yulin , Zhang Na , Zhang Xiaochu , Liu Shen 
Published: March 2024

ObjectiveThe aim of the current study was to provide a comprehensive picture of tACS-related research in the last decade through a bibliometric approach in order to systematically analyze the current status and cutting-edge trends in this field.MethodsArticles and review articles related to tACS from 2013 to 2022 were searched on the Web of Science platform. A bibliometric analysis of authors, journals, countries, institutions, references, and keywords was performed using CiteSpace (6.2.R2), VOSviewer (1.6.19), Scimago Graphica (1.0.30), and Bibliometrix (4.2.2).ResultsA total of 602 papers were included. There was an overall increase in annual relevant publications in the last decade. The most contributing author was Christoph S. Herrmann. Brain Stimulation was the most prolific journal. The most prolific countries and institutions were Germany and Harvard University, respectively.ConclusionThe findings reveal the development prospects and future directions of tACS and provide valuable references for researchers in the field. In recent years, the keywords “gamma,” “transcranial direct current simulation,” and “Alzheimer’s disease” that have erupted, as well as many references cited in the outbreak, have provided certain clues for the mining of research prefaces. This will act as a guide for future researchers in determining the path of tACS research.