bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement of the Energy-Generating Capacity of Human Muscle Mitochondria: Diagnostic Procedure and Application to Human Pathology
Authors: Janssen Antoon JM , Trijbels Frans JM , Sengers Rob CA , Wintjes Liesbeth TM , Ruitenbeek Wim , Smeitink Jan AM , Morava Eva , van Engelen Baziel GM , van den Heuvel Lambert P , Rodenburg Richard JT 
Published: March 2006

AbstractBackground: Diagnosis of mitochondrial disorders usually requires a muscle biopsy to examine mitochondrial function. We describe our diagnostic procedure and results for 29 patients with mitochondrial disorders.Methods: Muscle biopsies were from 43 healthy individuals and 29 patients with defects in one of the oxidative phosphorylation (OXPHOS) complexes, the pyruvate dehydrogenase complex (PDHc), or the adenine nucleotide translocator (ANT). Homogenized muscle samples were used to determine the oxidation rates of radiolabeled pyruvate, malate, and succinate in the absence or presence of various acetyl Co-A donors and acceptors, as well as specific inhibitors of tricarboxylic acid cycle or OXPHOS enzymes. We determined the rate of ATP production from oxidation of pyruvate.Results: Each defect in the energy-generating system produced a specific combination of substrate oxidation impairments. PDHc deficiencies decreased substrate oxidation reactions containing pyruvate. Defects in complexes I, III, and IV decreased oxidation of pyruvate plus malate, with normal to mildly diminished oxidation of pyruvate plus carnitine. In complex V defects, pyruvate oxidation improved by addition of carbonyl cyanide 3-chlorophenyl hydrazone, whereas other oxidation rates were decreased. In most patients, ATP production was decreased.Conclusion: The proposed method can be successfully applied to the diagnosis of defects in PDHc, OXPHOS complexes, and ANT.
Midregional Pro-A-Type Natriuretic Peptide Measurements for Diagnosis of Acute Destabilized Heart Failure in Short-of-Breath Patients: Comparison with B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP
Authors: Gegenhuber Alfons , Struck Joachim , Poelz Werner , Pacher Richard , Morgenthaler Nils G , Bergmann Andreas , Haltmayer Meinhard , Mueller Thomas 
Published: March 2006

Abstract
Background: The aim of the present study was to assess the utility of amino-terminal pro-A-type natriuretic peptide (NT-proANP) measurements for the emergency diagnosis of acute destabilized heart failure (HF), using a novel sandwich immunoassay covering midregional epitopes (MR-proANP).
Methods: The retrospective analysis comprised 251 consecutive patients presenting to the emergency department of a tertiary care hospital with dyspnea as a chief complaint. The diagnosis of acute destabilized HF was based on the Framingham score for HF plus echocardiographic evidence of systolic or diastolic dysfunction. A commercially available immunoluminometric assay was used for measurement of MR-proANP plasma concentrations.
Results: Median MR-proANP plasma concentrations were significantly higher in patients with dyspnea attributable to acute destabilized HF (338 pmol/L; n = 137) than in patients with dyspnea attributable to other reasons (98 pmol/L; n = 114; P &lt;0.001). The area under the curve for MR-proANP was 0.876 (SE = 0.022; 95% confidence interval, 0.829–0.914), and the cutoff concentration with the highest diagnostic accuracy was 169 pmol/L (sensitivity, 89%; specificity, 76%; diagnostic accuracy, 83%). In the setting evaluated, diagnostic information obtained by MR-proANP measurements was similar to that obtained with B-type natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) measurements.
Conclusions: MR-proANP measurements may be useful as an aid in the diagnosis of acute destabilized HF in short-of-breath patients presenting to an emergency department. The diagnostic value of MR-proANP appears to be comparable to that of BNP and NT-proBNP.
Human plasma adenosine deaminase 2 is secreted by activated monocytes
Authors: Iwaki-Egawa Sachiko , Yamamoto Takaya , Watanabe Yasuhiro 
Published: March 2006

AbstractAdenosine deaminase (ADA) plays an important role in the immune system, and its activity is composed of two kinetically distinct isozymes, ADA1 and ADA2. ADA2 is a major component of human plasma total ADA activity and ADA2 activity is significantly elevated in patients with various diseases such as HIV infection and chronic hepatitis. However, relatively little is known about ADA2 because of difficulties in purifying this enzyme. In this study we succeeded in purifying human plasma ADA2 and demonstrate the extracellular secretion of ADA2 from human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate and calcium ionophore.
Abstimmbarer Pr/Yb-dotierter Faserlaser im cw- und Pulsmodebetrieb (An All-Fiber Pr/Yb-Doped Up-Conversion Laser in Different Laser Operation Modes)
Authors: Zeller Marcel , Limberger Hans , Lasser Theo 
Published: March 2006

Abstract
Faserlasersysteme bieten eine interessante Möglichkeit für Laserquellen mit hoher Strahlqualität im sichtbaren Spektralbereich. Pr/Yb-dotierte Fasersysteme mit Emissionslinien im roten, orangen, grünen und blauen Spektralbereich wurden als abstimmbare Laser (zentrale Wellenlänge 605 nm, Abstimmbereich ca. 8 nm) und als modengelockte Lasersysteme mit Pulsdauern kleiner 100 ps betrieben. Als Gainmedium wurden Pr/Yb-dotierte Fluoridfasersysteme verwendet, während sowohl der gesamte Laserresonator als auch die Modelockingeinheit als quarzfaserbasierte Hybridkomponente realisiert wurden.
Details of the spoken word; Ethnics and Epistemology in the Social Sciences; Passion and Politics;
Authors: Crowley Daniel J. , Handler Richard , Ridington Robin 
Published: March 2006

Dennis Tedlock The Spoken Word and the Work of Interpretation. Philadelphia: University of Pennsyslvania Press. 1983. xi. 365 pp. $35.00 (cloth)Norma Haan. Robert N. Bellah. Paul Rabinow. William M. Sullivan. eds. Social Science as Moral Inquiry. New York: Columbia University Press. 1983. xiv. 392 pp. $40.00 (cloth), $12.00 (paper).F. G. Bailey The Tactical Uses of Passion. Ithaca and London: Cornell University Press. 1983. 275 pp. $29.50 (cloth)
One Author and Two Ethnographic Novels of Tibet
Authors: Schuchat Molly G. 
Published: March 2006

Robert B. Ekvall. Tents Against the Sky. Westchester, IL: Good News Publishers, 1978. First published in the U.S. by Farrar, Straus & Young, 1954. 264 pp. Map. $4.95 (paper)Robert B. Ekvall. The Lama Knows. Tibetan Legend Is Born. Foreword to 1981 Edition by L. L. Langness. Novato, CA: Novato & Sharp Publishers, Inc., 1981. First published by Gulab Primlani, New Delhi, India, 1979. xvi. 127pp. Illustrations. $5.95 (paper)
The Ojibwa as Moderns: Victims and Survivors
Authors: Vanderburgh Rosamond M. 
Published: March 2006

J. Anthony Paredes. ed. Anishnabe: Six Studies of Modern Chippewa. Tallahassee, Florida: University Presses of Florida, 1980. xi. 436 pp. $27.50 (cloth).Yngve Georg Lithman. The Community Apart:. Case Study of. Canadian Indian Reserve Community. Winnipeg, Manitoba: University of Manitoba Press, 1984. vi. 186 pp. $20.00 (cloth), $5.95 (paper).Anastasia M. Shkilnyk. A Poison Stronger than Love: the Destruction of an Ojibwa Community. New Haven, Connecticut: Yale University Press, 1985. xx. 275 pp. $30.00 (cloth), $9‐95 (paper).
Contrasting Roles of Privacy
Authors: Lee Alfred McClung 
Published: March 2006

Barrington Moore. Jr. Privacy: Studies in Social and Cultural History. Armonk, New York: M. E. Sharpe, 1984. xiv. 328 pp. $17.25 (cloth)Franco Ferrarotti. The Myth of Inevitable Progress. Westport, Conn.: Greenwood Press, 1985. viii. 208 pp. $35 (cloth)
Art in Flux: Songs, Poems, and Pots
Authors: Anderson Richard L. 
Published: March 2006

David B. Coplan. In Township Tonight: South Africa's Black City Music and Theater. London: Longman, 1985. + 278 pp. $29.95 (cloth), $12.95 (paper).Terese Svoboda. Cleaned the Crocodile's Teeth: Nuer Song. Greenfield, N.Y.: Greenfield Review Press, 1985. ix. 104 pp. $9.95 (paper).Louana M. Lackey. The Pottery of Acatlán:. Changing Mexican Tradition. Norman: University of Oklahoma Press, 1982. xi. 164 pp. $29.50 (cloth).
Two Accounts of Japan
Authors: Schedler Gilbert 
Published: March 2006

Brian Moeran. Okubo Diary: Portrait of. Japanese Valley. Stanford, CA: Stanford University Press, 1985. viii plus 257 pp. (cloth).Gail Lee Bernstein. Haruko's World:. Japanese Farm Woman and Her Community. Stanford, CA: Stanford University Press, 1983‐ xviii plus 199 pp., illus. (Paper and cloth).
On Finding Matriarchy in Unexpected Places
Authors: Quade Larry G. 
Published: March 2006

Barbara Raskin. Hot Flashes. New York: St. Martin's Press. 1987. 376 pp. $18.95 (cloth).Lionel Shriver. The Female of the Species. New York: Farrar/Straus/Giroux. 1987. 405 pp. $17.95 (cloth).Shelby Hearon. Five Hundred Scorpions. New York: Atheneum. 1987. 306 pp. $18.95 (cloth).
Changing Perspectives in African History
Authors: Nevadomsky Joseph 
Published: March 2006

Bogumil Jewsiewicki and David Newbury. eds. African Historiographies: What History for Which Africa? Beverly Hills: Sage Publications, 1985. 320 pp. $29.95 (cloth).Catherine Coquery‐Vidrovitch and Paul Lovejoy. eds. The Workers of African Trade. Beverly Hills: Sage Publications, 1985. 304 pp. $29.95 (cloth).
Book Reviews
Authors: Walck Christa L. , Keehle Kevin , Philpott Stuart B. , Lurie Sue G. , Weil Jim 
Published: March 2006

American enterprise in Japan. Tomoko Hamada. Albany, NY: State University of New York Press, 1991. xi +294 pages.Does Training Work for Displaced Worker?;. survey of existing data. D.E. Leigh. W.E. Upjohn Institute for Employment Research, 1990.Red November, Black November. Culture and Community in the Industrial Workers of the World. Salvatore Salerno. Albany: State University of New York Press, 1989. 220pp.Inhuman Relations: Quality Circles and Anti‐unionism in American Industry. Cuillermo Grenier. Philadelphia: Temple University Press, xx. 232 pp. 1988.Blue Collar and Buddha. Taggart Siegel and Kati Johnson. 1987.57 min. Siegel Productions, Chicago. Saudade (Nostalgia). Bela Feldman‐Bianco. 1991.57 min. Documentary Educational Resources, Watertown, MA.
Medicalized Mothering: Perspectives from the Lives of African‐American and Jewish Women; Measuring Mama's Milk: Fascism and the Medicalization of Maternity in Italy
Authors: Wozniak Danielle F. 
Published: March 2006

Medicalized Mothering: Perspectives from the Lives of African‐American and Jewish Women. Jacquelyn S. Litt. New Brunswick, NJ: Rutgers University Press, 2000. xi+ 189 pp.Measuring Mama's Milk: Fascism and the Medicalization of Maternity in Italy. Elizabeth Dixon Whitaker. Ann Arbor: University of Michigan Press, 2000. vii. 358 pp.
The Book Review Section (Commentary, Reviews, Recent Publications)
Authors: Khan Baduddin , Kennedy Matthew , Murray Stephen O. 
Published: March 2006

Sexuality and Eroticism among Males in Moslem Societies, edited by Arno Schmitt and Jehoeda Sofer. New York: Haworth Press, 1992. 201 pp.Vested Interests: Cross‐Dresslng & Cultural Anxiety by Marjorie Garber. New York: Routledge. 443 pp. $35 hb.Homosexuality. Society and the State In Mexico by Ian Lumsden. Toronto: Canadian Gay Archives. (P.O. Box 639, Station A, Toronto, Ont. M5# 1G2, Canada). 122 pp. pb. $12.95 Canadian. $3 postage/handling (for Spanish or English version).
The Book Review Section (Commentary, Reviews, Recent Publications)
Authors: Lemay Helen Rodnite , Manalansan Martin F. , Paloma Luis , Murray Stephen O. 
Published: March 2006

Sex, Dissidence and Damnation: Minority Groups in the Middle Ages, by Jeffrey Richards. (New York: Routledge, 1991).Oceanic Homosexuality, by Stephen 0. Murray. (New York: Garland Publishing 1992).Gay Culture in America: Essays from the Field, edited by Gilbert Herdt (Boston: Beacon Press, 1992), 255 pp.; and Not in front of the Audience: Homosexuality on Stage by Nocholas de Jongh (New Tork: Routledge, 1992), 214 pp., $49.95 hb, $15.95 pb.AIDS and Accusation: Haiti and the Geography of Blame by Paul Farmer. Berkeley: University of California Press, 1992. 338 pp. $35 hb.Notes on Incidents by Roland Barthes and Bringing Out Roland Barthes by D. A. Miller (Berkeley: University of California Press, 1992, $12. piece, or $20 for the pair); Understanding the Male Hustler by Sam Steward (Binghamton, NY: Harrington Park Press, 1991, $7.95 pb. 147 pp.) Colin McPhee: Composer in Two Worlds by Carol J. Oja. (Washington: Smithsonian Institution Press, 1990. $39.95 hb.)
The Book Review Section (Commentary, Reviews, Recent Publications)
Authors: Bernstein Mary , Fitzgerald Tom , Murray Stephen O. 
Published: March 2006

The Gay and Lesbian Liberation Movement, by Margaret Cruikshank. (New York: Routledge, 1992.)The Taste of Blood: Spirit Possession in Brazilian Candomble. by Jim Wafer. (Philadelphia: University of Pennsylvania Press, 1991).Games of Venus: An Anthology of Greek and Roman Erotic Verse from Sappho to Ovid edited by Peter Bing and Rip Cohen (New York: Routledge, 1991. 279 pp. $28.95 hb.) and Homosexual Desire in Shakespeare's England:. Cultural Poetics by Bruce R. Smith. (Chicago: University of Chicago Press, 1991.) 329+xii pp.$29.95 hb.
The Book Review Section (Commentary, Reviews, Recent Publications)
Authors: Burg B.R. , Murray Stephen O. , Khan Baduddrin , De Danaan LLyn , Donovan James M. 
Published: March 2006

Barrack Buddies and Soldier Lovers: Dialogues with Gay Young Men in the U.S. Military. By Steven Zeeland. With. foreword by Allan Berube. Binghampton, N. Y.: Harrington Park Press, 1993. Pp. xii+293. $14.95 (paper).The Dove Coos: Gay Experiences by the Men of Thailand, edited by Eric AUyn. (Bangkok: Bua Luang, 1992; distributed by Orchid House, 2215‐R Market St., San Francisco, CA 94114). $11.95 pb. 134 pp.Lotus of Another Color: An unfolding of the South Asian Gay and Lesbian Experience, edited by Rakesh Ratti. (Boston: Alyson).What. Lesbian Looks Like: Writings by Lesbians on their Lives and Lifestyles. National Lesbian and Gay Survey. London:Routledge. 1992. 166 pp. (paper)If You Seduce. Straight Person, Can You Make Them Gay?: Issues in Biological Essentialism versus Social Constructionism in Gay and Lesbian Identities, edited by John P. DeCecco and John P. Elia. (New York: Harrington Park Press.) 1993. xvi, 266, index.
Book Reviews
Authors: De Danaan LLyn , Murray Stephen O. 
Published: March 2006

Modern Homosexualities: Fragments of Lesbian and Gay Experience, edited by Ken Plummer (London and New York: Routledge, 1992) 281 pages, paperback.Growing Up Before Stonewall: life Stories of Some Gay Men by Peter M. Nardi. David Sanders. and Judd Marmor. New York: Routledge, 1994. 177+ix pp. $16.95 paperback.
Photoionization Thresholds of Melanins Obtained from Free Electron Laser‐Photoelectron Emission Microscopy, Femtosecond Transient Absorption Spectroscopy and Electron Paramagnetic Resonance Measurements of Oxygen Photoconsumption
Authors: Ye Tong , Hong Lian , Garguilo Jacob , Pawlak Anna , Edwards Glenn S. , Nemanich Robert J. , Sarna Tadeusz , Simon John D. 
Published: March 2006

ABSTRACTFree electron laser‐photoelectron emission microscopy (FEL‐PEEM), femtosecond absorption spectroscopy and electron paramagnetic resonance (EPR) measurements of oxygen photoconsumption were used to probe the threshold potential for ionization of eumelanosomes and pheomelanosomes isolated from human hair. FEL‐PEEM data show that both pigments are characterized by an ionization threshold at 282 nm. However, pheomelanosomes exhibit a second ionization threshold at 326 nm, which is interpreted to be reflective of the benzothiazine structural motif present in pheomelanin and absent in eumelanin. The lower ionization threshold for pheomelanin is supported by femtosecond transient absorption spectroscopy. Unlike photolysis at 350 nm, following excitation of solubalized synthetic pheomelanin at 303 nm, the transient spectrum observed between 500 and 700 nm matches that for the solvated electron, indicating the photoionization threshold for the solubalized pigment is between 350 and 303 nm. For the same synthetic pheomelanin, EPR oximetry experiments reveal an increased rate of oxygen uptake between 338 nm and 323 nm, narrowing the threshold for photoionization to sit between these two wavelengths. These results on the solubalized synthetic pigment are consistent with the FEL‐PEEM results on the human melanosomes. The lower ionization potential observed for pheomelanin could be an important part of the explanation for the greater incidence rate of UV‐induced skin cancers in red‐haired individuals.
5‐Aminolevulinic Acid Derivatives in Photomedicine: Characteristics, Application and Perspectives
Authors: Fotinos Nicolas , Campo Marino A. , Popowycz Florence , Gurny Robert , Lange Norbert 
Published: March 2006

ABSTRACTThe introduction of lipophilic derivatives of the naturally occurring heme precursor 5‐aminolevulinic acid (5‐ALA) into photomedicine has led to a true revival of this research area. 5‐ALA‐mediated photodynamic therapy (PDT) and fluorescence photodetection (FD) of neoplastic disease is probably one of the most selective cancer treatments currently known in oncology. To date, this method has been assessed experimentally for the treatment of various medical indications. However, the limited local bioavailability of 5‐ALA has widely prevented its use in daily clinical practice. Although researchers were already aware of this drawback early during the development of 5‐ALA‐mediated PDT, only recently have well‐established concepts in pharmaceutical science been adapted to investigate ways to overcome this drawback. Recently, two derivatives of 5‐ALA, methylaminolevulinate (MAL) and hexylaminolevulinate (HAL), gained marketing authorization from the regulatory offices in Europe and Australia. MAL is marketed under the trade name Metvix for the treatment of actinic keratosis and difficult‐to‐treat basal cell carcinoma. HAL has recently been launched under the trade name Hexvix to improve the detection of superficial bladder cancer in Europe. This review will first present the fundamental concepts underlying the use of 5‐ALA derivatives in PDT and FD from a chemical, biochemical and pharmaceutical point of view. Experimental evidences from preclinical data on the improvements and limits observed with 5‐ALA derivatives will then be introduced. The state‐of‐the‐art from clinical studies with 5‐ALA esters will be discussed, with special emphasis placed on the process that led to the development of MAL in dermatology and to HAL in urology. Finally, we will discuss promising medical fields in which use of 5‐ALA derivatives might potentially lead to further use of this methodology in photomedicine.
Phytochrome‐dependent Photomovement Responses Mediated by Phototropin Family Proteins in Cryptogam Plants†
Authors: Suetsugu Noriyuki , Wada Masamitsu 
Published: March 2006

AbstractIn this review, we describe the regulation of photomovement responses by phototropin and phytochrome photoreceptors. The blue light receptor phototropin mediates various photomovement responses such as phototropism, chloroplast movement and stomatal opening. In cryptogamic plants including ferns, mosses and green alga, red as well as blue light mediates phototropism and chloroplast movement. The red/far‐red light reversibility suggests the involvement of phytochrome in these responses. Thereby, plant growth is presumably promoted by coordinating these photomovements to capture efficiently light for photosynthesis.
Dynamic consolidation of a saturated plastic clayey fill
Authors: Perucho A. , Olalla C. 
Published: March 2006

Dynamic consolidation has been used to improve a plastic clayey fill in a port area reclaimed from the sea, with the blows from a 140 kN hammer dropped from heights ranging from 7 to 10 m onto a grid of impact points. The improvement achieved was evaluated on the basis of laboratory test results (dry density, moisture content, void ratio and oedometric tests) and field tests (standard penetration tests, continuous heavy dynamic penetration, static penetration and pressuremeter tests) conducted before and after the improvement. On the basis of the test results the interpreted improvements obtained can be regarded as satisfactory. Nous avons utilisé la consolidation dynamique afin d'améliorer un remblai argileux plastique dans une zone portuaire récupérée sur la mer, consolidation réalisée avec les frappes d'un marteau de 140 kN tombant de hauteurs allant de 7 à 10 m sur un réseau de points d'impact. Nous avonsé valué l'amélioration ainsi obtenue en nous basant sur les résultats de tests en laboratoire (densité sèche, teneur en eau, taux de pore et essais à l'oedomètre) et d'essais sur le terrain (SPT, pénétration dynamique lourde en continu, pénétration statique et essais au pressiomètre) menés avant et après l'amélioration. Sur la base des résultats de ces essais, les améliorations obtenues, une fois interprétées, peuvent ê tre considérées comme satisfaisantes.
Effectiveness of cement on hydraulic conductivity of compacted soil–cement mixtures
Authors: Bellezza I. , Fratalocchi E. 
Published: March 2006

The paper presents the results of an experimental study on the hydraulic conductivity of compacted soil-cement mixtures. The effectiveness of 5% cement addition is evaluated by the permeability value at 28 days' curing and by the ratio of the hydraulic conductivity of the untreated soil to that of the mixture, both compacted wet of optimum with a Proctor Standard effort. Laboratory compaction and permeability tests were performed on 15 soils of different grain size (sandy to clayey soils) and mineralogy. For all the investigated soil-cement mixtures hydraulic conductivity values lower than 2 × 10−7 cm/s have been achieved after the cement addition. A statistical analysis was developed in order to evaluate relationships between hydraulic conductivity and soil compositional and compaction variables. Prediction models for all soil types and for fine-grained soils are given. In particular, for fine-grained soils a regression equation is proposed that can be used to reliably predict the hydraulic conductivity of compacted soil-cement mixture as a function of clay fraction, fine fraction and liquid limit. Practical applications of the proposed prediction models and the precautions for using them are discussed. Cet exposé présente les résultats d'uneé tude expérimentale sur la conductivité hydraulique de mixtures sol-ciment compactées. L'efficacité de l'adjonction de ciment esté valueé à 5% en utilisant la valeur de perméabilité après 28 jours de cuisson et en utilisant le rapport entre la perméabilité du sol non traité et celle de la mixture, dans les deux cas sous compactage mouillé optimum avec un effort Proctor Standard. Le compactage en laboratoire et les essais de perméabilité onté té effectués sur 15 sols avec différentes tailles de grains (sableux à argileux) et différentes minéralogies. Pour toutes les mixtures sol-cimenté tudiées, des valeurs de conductivité hydraulique inférieures à 2 3 1027 cm/s onté té obtenues après adjonction de ciment. Nous avons développé une analyse statistique pouré valuer les relations entre la conductivité hydraulique et les variantes quant à la composition du sol et au compactage. Nous donnons des modèles de prédiction pour tous les types de sol et pour les sols àgrains fins. Pour les sols à grains fins en particulier, nous proposons uneé quation de régression qui peut être utilisée pour prédire avec fiabilité la conductivité hydraulique de mixtures sol-ciment compactées comme fonction de la fraction argileuse, de la fraction fine et de la limite liquide. Nous discutons des applications pratiques des modèles de prédiction proposés ainsi que des précautions à prendre pour les utiliser.