bluuebunny/crossref_metadata_2025_split huggingface dataset:
Khảo sát tác động giảm đau, kháng viêm của cao chiết xuất từ quả Chuối hột rừng (Musa acuminata Colla. Musaceae) trên chuột nhắt trắng
Authors: Võ Thị Thu Hà  , Nguyễn Trần Hưng Yên  , Võ Thế Sang  
Published: April 2024

Ở Việt Nam, trong dân gian Chuối hột rừng (Musa acuminata Colla., Musaceae) được sử dụng để điều trị một số bệnh như đau khớp, tiêu chảy, dị ứng... Nghiên cứu này khảo sát sơ bộ thành phần hóa học, xác định độc tính cấp và tác dụng giảm đau, kháng viêm của cao chiết từ quả Chuối hột rừng chín thu hái từ Tây Nguyên. Cao đặc thu được bằng cách ngấm kiệt quả Chuối hột rừng với cồn 60 %. Các nhóm hoạt chất được định tính bằng phương pháp Ciuley. Trong thử nghiệm độc tính cấp, cho chuột uống cao với liều tối đa có thể. Quan sát và ghi nhận sự thay đổi hành vi tổng quát, các tác dụng phụ và tỷ lệ tử vong trong 72 giờ và tiếp tục theo dõi 14 ngày sau khi điều trị. Tác động giảm đau trung ương được khảo sát trên mô hình nhúng đuôi chuột và tác động giảm đau ngoại biên - trên mô hình gây đau quặn bụng bằng axit acetic 1 %. Tác động kháng viêm được khảo sát theo mô hình gây phù chân chuột bằng carrageenan 1 %. Phân tích định tính phytochemical của chiết xuất cho thấy sự hiện diện của nhiều hợp chất hoạt tính sinh học triterpenoid tự do, flavonoid, tannin, proanthocyanosid, saponin, axit hữu cơ, polyuronic. Kết quả cho thấy liều dung nạp tối đa ( ) có thể gây tử vong là 26 g/kg (cao cồn Chuối hột rừng/khối lượng cơ thể chuột). Cao chiết chuối hột rừng liều 1,3 g/kg và 2,6 g/kg có tác động kháng viêm và giảm đau ngoại biên nhưng không có tác động giảm đau trung ương. Kết quả này giúp nghiên cứu sâu hơn các dạng chế phẩm tự nhiên trong hỗ trợ điều trị các bệnh mãn tính như viêm xương khớp.
Xây dựng và thẩm định quy trình định lượng vicenin 2 trong Rau đắng đất (Glinus oppositifolius (L.) DC., Molluginaceae)
Authors: Nguyễn Thị Thu Hiền  , Hà Mỹ Nhân  
Published: April 2024

Vicenin 2 là một flavonoid tự nhiên, có hoạt tính sinh học được chiết xuất từ nhiều loài thực vật, bao gồm Rau đắng đất (Glinus oppositifolius (L.) DC.,) Các nghiên cứu gần đây đã chỉ ra rằng vicenin 2 có tác dụng chống viêm, bảo vệ gan, hạ đường huyết, chống ung thư, … Nghiên cứu đã tiến hành xây dựng và thẩm định quy trình định lượng vicenin 2 trong Rau đắng đất bằng HPLC-PDA đồng thời thẩm định các chỉ tiêu của quy trình định lượng, từ đó đề xuất một quy trình mới để định lượng vicenin 2 trong Rau đắng đất. Quy trình sử dụng cột sunfire C18 (4,6 × 150 mm, 5 µm), phát hiện ở bước sóng 335 nm, pha động CH3CN–HCOOH 0,1 %. “Dược điển Việt Nam V” đã có chuyên luận về Rau đắng đất nhưng chưa có tiêu chuẩn định lượng nên đây sẽ làm tiền đề để xây dựng quy trình định lượng các hoạt chất trong dược liệu này. Có thể áp dụng rộng rãi quy trình này, góp phần đưa các phương pháp kiểm nghiệm hiện đại để kiểm soát chất lượng Rau đắng đất nói riêng cũng như kiểm soát chất lượng dược liệu và các chế phẩm từ dược liệu nói chung.
® 2023 Journal of Science and Technology - NTTU
Unearthing the Diasporic bhadramahila in Jhumpa Lahiri’s Unaccustomed Earth and Bharati Mukherjee’s Desirable Daughters
Authors: Crespo Gómez Ana María 
Published: April 2024

This study aims to examine the influence of the bhadramahila construct both in the Bengal colonial context and its reproduction in the imaginary of the Indian American family dynamics. The works under discussion are: Jhumpa Lahiri’s short story anthology Unaccustomed Earth (2008) and Bharati Mukherjee’s novel Desirable Daughters (2002). Both give evidence to the academic discussions on the position of the bhadralok and bhadramahila in Bengal (India) during colonial times, a rare topic in both Lahiri’s and Mukherjee’s stories. The article puts into perspective the making of the “New Woman” in Bengal in the nineteenth century, then moves to the literary section where it analyses how female characters reproduce their cultural baggage in a hybrid setting and deal with inner conflicts, hence inaugurating the figure of the diasporic bhadramahila in the context of the United States.
ANÁLISE BIBLIOMÉTRICA SOBRE TRANSTORNO DE DÉFICIT DE ATENÇÃO E HIPERATIVIDADE NO BRASIL NO PERÍODO DE 2018 A 2022
Authors: Kerr Kelvin da Silva , Maia Edwagner Coutinho , Ponte Nicole Patrícia de Lima Vinagre da 
Published: April 2024

O presente trabalho teve como objetivo principal realização de um levantamento dos estudos publicados sobre o transtorno de déficit de atenção e hiperatividade (TDAH) no Brasil, bem como identificou possíveis lacunas de pesquisa. Trata-se de um estudo descritivo, transversal e quantitativo. Os dados foram baseados em estudos publicados no Brasil na plataforma Web of Science com os seguintes descritores “TDAH”, “ADHD”, “Transtorno de déficit de atenção e hiperatividade”, “Attention déficit and hyperactivity disorder” e “Brazil”. A análise de dados foi realizada com ajuda dos softwares Excel (2019), VosViewer, Rstudio e Bibliometrix. Os trabalhos de autores brasileiros (494) eram, em sua grande maioria, das regiões Sul e Sudeste realizados com colaboração internacional, principalmente com os Estados Unidos; a maioria dos periódicos responsáveis pela publicação dos artigos era estrangeira. Verificou-se uma queda significativa nas publicações em 2020, possivelmente relacionada com o surgimento da pandemia da COVID-19. Concluiu-se que a comunidade científica brasileira necessita fomentar mais estudos relacionados ao TDAH e, possivelmente, esta lacuna pode ser uma consequência da carência do incentivo à pesquisa no país.
Pengaruh Prior Experince, Variety Seeking Dan Product Knowledge Terhadap Brand Switching
Authors: Rosyidah Fathma Eviyana , Cholidah Lilik Nur , Sulaeman Moh Muklis 
Published: April 2024

Perusahaan kecantikan sangat kompetitif dengan banyak merek bermunculan dengan menciptakan produk sejenis untuk mendapatkan pagsa pasar. Penelitihan ini bertujuan untuk mengetahui pengaruh Prior Experince, Variety Seeking dan Product Knowledge terhadap Brand Switching. Populasi dalam penelitihan ini adalah konsumen wardah di lamongan. Penlitihan ini menggunakan metode penelitihan kuantitatif. Pengambilan sample menggunakan metode purposive sampling dan rumus Slovin diperoleh hasil sebanyak 94 responden. Hasil penelitihan menunjukkan bahwa variabel variety seeking terhadap brand switching berpengaruh negatif serta signifikan. Sedangkan Prior Experince dan Product Knowledge terhadap Brand Switching berpengaruh positif serta signifikan. Berdasarkan hasil nilai R2 (koefesien determinan) faktor Prior Experience, Variety Seeking dan Product Knowledge mempengaruhi Brand Switching sebesar 68,7 % sehingga sisanya sebesar 31,3 % di pengaruhi variabel yang tidak diteliti pada penelitihan ini. Penelitian ini memberikan kontribusi pada pemahaman tentang pengambilan keputusan konsumen dalam sektor kecantikan, menyoroti peran rumit dari pengalaman, pengetahuan, dan pencarian variasi dalam membentuk preferensi merek. Sementara penelitian selanjutnya dapat mengeksplorasi variabel tambahan yang mempengaruhi Perpindahan Merek untuk memberikan pemahaman yang lebih komprehensif tentang perilaku konsumen dalam industri yang sangat kompetitif
Educação e Tecnologia
Authors: Lageano Neto de Jesus Djanires , Do Nascimento Sambugari Márcia Regina , Moises Ronaldo Rodrigues 
Published: April 2024

Há algum tempo as tecnologias vêm ganhando espaço no contexto educacional e principalmente, nestes últimos anos elas passaram a compor a vida escolar em diversos níveis, da educação básica ao ensino superior. É com essas tecnologias e por meio dela, que escolas e Instituições de Ensino Superior (IES) mantiveram seu calendário escolar e acadêmico, oferecendo a continuidade do ensino pelo mundo. Contudo, as Tecnologias da Informação e da Comunicação (TICs) tiveram início anos de 1960 e 1970 e surgiram para modificar a interação e comunicação das pessoas pelo mundo, trazendo não somente uma mudança social, mas também anunciando como o acesso ao conhecimento se transformaria (DOMINICK; ALVES, 2018).
A pandemia do Coronavírus (COVID-19) modificou a forma de comunicação no mundo, para mitigar as contaminações, escolas e IES foram fechadas e o ensino passou a ser ofertado por meio de Ambientes Virtuais de Aprendizagem (AVA), de escolha das instituições de ensino. As salas de aulas foram substituídas por salas virtuais e tanto docentes como estudantes precisaram se reinventar do dia para noite (SILUS; FONSECA; JESUS, 2020).
Com a chegada do Coronavírus e a implantação do Ensino Remoto Emergencial (ERE), as tecnologias de informação se tornaram essenciais. Nos últimos anos, o mundo digital e a acessibilidade às tecnologias digitais passaram a ser utilizadas em escalas exponenciais e as TICs, a ser denominadas Tecnologias Digitais de Informação e Comunicação (TDICs). Entretanto, o uso das TDICs não pode estar desconectado de um bom direcionamento pedagógico, ou seja, existe a necessidade da elaboração de políticas públicas no Brasil para acelerar o processo de inclusão digital nas escolas, que incluem ações como: melhorar a qualidade do processo de ensino-aprendizagem por meio das TDICs; promover uma educação científica e tecnológica e possibilitar a criação de um ecossistema de inovação por meio das tecnologias (SILVA, 2011). Tais ações vinham sendo organizadas, mas as políticas principalmente nas Instituições de Ensino, que oferecem cursos exclusivamente na modalidade presencial, ainda estavam longe de chegar ao que estamos vivendo hoje, uma educação mais híbrida...
REALIDADE DA BALANÇA DE PODER: ARGUMENTOS PRÓS E CONTRAS
Authors: Dagios Magnus 
Published: April 2024

A pesquisa desenvolvida tenta explicar os principais aspectos da teoria da balança de poder e sua variante, o equilíbrio do terror. Em que medida ela é adequada para explicar as relações interestatais e se de fato ela consegue ocasionar o equilíbrio e a estabilidade almejada? Através de uma investigação bibliográfica sobre os conceitos principais e os motivos de que se servem os vários teóricos das relações internacionais para defender essa posição, quais seriam os pontos fortes e fracos que estão entrelaçados no debate? Será utilizado as propostas do jurista e filósofo italiano Norberto Bobbio como contraponto à doutrina realista. Como resultado, Bobbio mostra a importância da busca por uma consciência atômica, e como ela pode combater a vontade de potência.
Pendampingan Ibadah Umrah Jamaah Jannah Firdaus dalam Membangun Keluarga Berdaya Bulan Ramadhan 1444 H
Authors: Fajar M. Samson , Enizar Enizar 
Published: April 2024

Umrah adalah ibadah ritual yang sangat dirindukan oleh umat Islam, terutama bagi mereka yang berkeluarga, pasti memiliki harapan melaksanakan umrah bersama orang-orang yang dicintai. Salah satu nilai umrah yang tertuang dalam sejarah adalah hadirnya keluarga yang berdaya, digambarkan dengan sosok keluarga Nabi Ibrahim as, Hajar as dan Nabi Ismail, as. Sehingga dengan latar belakang ini hakikatnya umrah bukan sekedar ibadah ritual saja, akan tetapi ibadah yang hendaknya membentuk umat Islam memiliki kesadaran berkeluarga seperti Nabi Ibrahim as. Menjadikan keluarga berdaya berdasarkan spirit nilai-nilai Umrah yang diwariskan oleh mereka. Sehingga dibutuhkan pendampingan Ibadah umrah dalam rangka menggali spirit keluarga Nabi Ibrahim as untuk membangun keluarga berdaya. Adapun metode dalam pendampingan ini adalah spirituality approach atau pendekatan untuk membangun kesadaran berkeluarga berdaya berdasarkan nilai-nilai spirtual umrah, baik melalui kajian manasik, kajian di masjid nabawi, kajian di masjidil haram, penyuluhan city tour dan penyuluhan dalam seluruh proses perjalanan. Dengan metode ini dapat membangkitkan kembali rasa cinta jamaah yang berangkat dengan keluarganya, serta memiliki semangat untuk meneladani keluarga Nabi Ibrahim as serta dampaknya mereka lebih memiliki motivasi kuat untuk membangun keluarga sakinah berdaya dan mencari rezeki lebih untuk dapat umrah kembali.
Occurrence and Removal Efficiencies of Four Antibiotics in Kisii and Kabarnet Waste Water Treatment Plants, Kenya
Authors: Wendott Joseph K. , Were Munyendo L.L. , Cherutoi Jackson , Odero Mark P. 
Published: April 2024

Background: Antibiotics are presently considered as emerging contaminants with adverse effects in the environment and the population such as the development of antimicrobial resistant genes (ARG) and antimicrobial resistant bacteria (ARB). This study was guided by objective entailing to determine the seasonal occurrences and removal efficiencies of four antibiotics in Kisii and Kabarnet waste water treatment plants in Kenya.
Place and Duration of Study: Waste water samples were picked from Suneka wastewater treatment plant in Kisii county and Kabarnet Level V Hospital in Baringo County Kenya in the months of June and December 2020
Methodology: Multiple samples were picked in Kisii and Kabarnet waste water treatment plants in the months of June and December correspond to the dry and wet seasons in Kenya. Collected waste water samples were centrifuged and filtered with glass microfiber filter papers and subsequently passed through a Solid phase extractor cartridge. High Performance Liquid Chromatography was used for quantification of antibiotics as per international commission for harmonization and subsequently applied for analysis.
Results: The results revealed that the dry season had higher antibiotic concentrations at 1.29, 0.09, 2.92 and 1.82 µg/l for sulphamethoxazole, trimethoprim, ampicillin and amoxicillin respectively for the Kisii waste water treatment plant and 0.18, 0.05, 1.34 and 0.09 µg/l respectively for Kabarnet waste water treatment plant. During the wet seasons the measured concentrations were 1.11, 0.14, 2.04 and 1.34 µg/l for sulphamethoxazole, trimethoprim, ampicillin and amoxicillin at the Kisii WWTP, and 0.14, 0.06, 1.01 and 0.09 µg/l for Kabarnet WWTP. The removal efficiencies in the WWTPs, ranged from a high of 94 % to a low of 11.11 % depending on the type of antibiotic in both wet and dry seasons.
Conclusion: Amoxicillin, ampicillin, trimethoprim and sulphamethaxazole were found in both Kisii WWTPs and Kabarnet WWTPs with nearly all antibiotics having a higher concentration of in the dry season than in the wet season. The highest calculated percentage removal was 94.03 % while the lowest calculated percentage removal was 7.14 %. The results suggest that the two WWTPs are effective for the removal of different types of antibiotics.
A Comparative Study of the Breast Feeding Practice of Mothers between Rural Area and Urban Area in Bangladesh
Authors: Ahmed Rasel , Akter Taslima , Khatun Sharmin , Raza Md Salim , Siddiqa Ayesha , Mamun Yousuf al 
Published: April 2024

The exclusive breast feeding is ideal nutrition and sufficient to support optimal growth and development for approximately the first 6 months of life and the later age breastfeeding provides complete nutrition for infants and children. But it is not properly maintained in Bangladesh with limited resources, such as Sirajganj, where poverty and illiteracy are prevalent. Poor nutritional status during childhood can have long-lasting consequences in adulthood, including health, mortality, and human capital. It was a community based cross sectional comparative study which was conducted on 500 hundred mothers and their 500 hundred children in which 250 mothers and 250 children from each of Sirajganj and Dhaka City were selected. The target respondents were selecting randomly. χ 2 test, and Pearson’s correlation was performed as P<0.05 level of significance. The study found that there was a higher number of female children and higher birth frequencies in Sirajganj and Dhaka City. The study assessed mothers' breast feeding practices, including knowledge of colostrums, first baby food feeding, initiation, and duration of exclusive breastfeeding. Sirajganj city mothers received more breastfeeding attention than Dhaka City mothers, with findings decreasing with child's birth order. Breast feeding privileges in Sirajganj City increase as mothers' education levels rise from low school to a bachelor's degree or higher. Breast-feeding prevalence in infants up to 12 months is influenced by factors like sex, maternal age, birth order, education, employment status, and mother's poverty income ratio. The sickness of children is also influence to stop breast-feeding. The child birth weight was found to comparatively lower in the Sirajganj city than Dhaka City.
From Zimbabwean Indigenous Knowledge: Scientific Substantiation of the Aphrodisiac Efficacy and Safety of Pittosporum viridiflorum in Male Rat Models
Authors: Chifamba J , Zengeni S 
Published: April 2024

Introduction: Pittosporum viridiflorum, the multi habitat thriving plant species is widely believed to have been the source of sexual prowess for the polygamous kings and elites of the mighty medieval empire known as ‘Great Zimbabwe’. Despite the lack of systematic scientific validation, the macerated roots fractions continue to be the aphrodisiacs of choice among Zimbabweans.
Aims: To scientifically validate the aphrodisiac claims using male rats’ sexual performance investigation protocols. To evaluate the toxicity profile and to identify the pharmacologically active metabolites present in the lyophilized hydro-ethanolic crude extracts.
Methodology: Four concentrations of prepared Pittosporum viridiflorum root extract doses of 200, 400, 800 and 2000mg/kg as well as a commercial 5 mg/kg sildenafil citrate (standard) and distilled water (control) dosages were gavaged to male rats (n = 5 animals per group) for 21 days. The crude extract was subjected to screening protocols for various secondary metabolites of pharmacological relevance as well as acute oral toxicity profiling using OECD 425 TG. The sexual behaviour, mating parameters and hormonal changes in the male rats were evaluated accordingly.
Observation and Results: Compared with the control, a significant increase in mating behaviour, mating performance and the serum hormonal levels were observed in test animals which showed a dose‑dependent bias. The phytoscreening evaluation confirmed the presence of saponins, phytosterols, flavonoids, di-terpenoids, tannins, and polyphenols. The Extract was toxicological safe with an LD50 above 2000mg/kg body weight.
Conclusion: Pittosporum viridiflorum has excellent aphrodisiac activity on rats and is toxicologically safe for oral use. The abundant phytochemicals found are known to be pharmacologically active with regards to modulation of sexual hormones as well as sexual enhancement. It was further concluded that the traditional belief is valid, the plant can indeed be used as an alternative to modern medicines for various sexual dysfunctions and sexual performance enhancement.
Adaptive regulation of MIMO linear systems against unknown sinusoidal exogenous inputs
Authors: Ficocelli Maurizio , Ben Amara Foued 
Published: October 2008

AbstractThis paper deals with the adaptive regulation problem in linear multi‐input multi‐output systems subject to unknown sinusoidal exogenous inputs, where the frequencies, amplitudes, and phases of the sinusoids are unknown and where the number of sinusoids is assumed to be known. The design of an adaptive regulator for the system under consideration is performed within a set ofQ‐parameterized stabilizing controllers. To facilitate the design of the adaptive regulator, triangular decoupling is introduced in part of the closed‐loop system dynamics. This is achieved through the proper selection of the controller state feedback gain and the structure of theQparameter. Regulation conditions are then presented for the case where the sinusoidal exogenous input properties are known. For the case where the sinusoidal exogenous input properties are unknown, an adaptation algorithm is proposed to tune theQparameter in the expression of the parameterized controller. The online tuning of theQparameter allows the controller to converge to the desired regulator. Convergence results of the adaptation algorithm are presented. A simulation example involving a retinal imaging adaptive optics system is used to illustrate the performance of the proposed adaptive system. Copyright © 2008 John Wiley & Sons, Ltd.
Real‐time signal processing for high‐density microelectrode array systems
Authors: Imfeld K. , Maccione A. , Gandolfo M. , Martinoia S. , Farine P.‐A. , Koudelka‐Hep M. , Berdondini L. 
Published: October 2008

AbstractThe microelectrode array (MEA) technology is continuously progressing towards higher integration of an increasing number of electrodes. The ensuing data streams that can be of several hundreds or thousands of Megabits/s require the implementation of new signal processing and data handling methodologies to substitute the currently used off‐line analysis methods. Here, we present one approach based on the hardware implementation of a wavelet‐based solution for real‐time processing of extracellular neuronal signals acquired on high‐density MEAs. We demonstrate that simple mathematical operations on the discrete wavelet transform (DWT) coefficients can be used for efficient neuronal spike detection and sorting. As the DWT is particularly well suited for implementation on dedicated hardware, we elaborated a wavelet processor on a field programmable gate array (FPGA) in order to compute the wavelet coefficients on 256 channels in real‐time. By providing sufficient hardware resources, this solution can be easily scaled up for processing more electrode channels. Copyright © 2008 John Wiley & Sons, Ltd.
Solar Cells, Photodetectors, and Optical Sources from Infrared Colloidal Quantum Dots
Authors: Sargent Edward H. 
Published: October 2008

AbstractOptoelectronic devices made via spin‐coating of soft materials onto an arbitrary substrate enable ready integration, low cost, and physical flexibility. The use of solution‐processed colloidal quantum dots offers the added advantage of quantum‐size‐effect tuning of material bandgap. Tuning across the near‐ and short‐wavelength infrared (SWIR) spectral regions enables applications in fiber‐optic communications, night vision and biomedical imaging, and efficient solar energy collection. Here we review progress in infrared solar cells, light sensors, and optical sources based on solution‐processed materials. The latest solution‐processed photovoltaics now provide 4.2% power conversion efficiencies in the infrared, placing them a factor of three away from enabling a doubling in overall solar power conversion efficiency of visible‐wavelength solution‐processed photovoltaics. The best solution‐processed photodetectors now provide sensitivities of 1013 Jones D* (normalized detectivity), exceeding the sensitivity of the best epitaxially grown SWIR photodetectors. Infrared optical sources, both broadband light‐emitting diodes and, more recently, lasers, have now also been reported at 1.5 µm.
Generation and phenotyping of mCd59a and mCd59b double‐knockout mice
Authors: Qin Xuebin , Hu Weiguo , Song Wenping , Grubissich Luciano , Hu Xuemei , Wu Gongxiong , Ferris Sean , Dobarro Martin , Halperin Jose A. 
Published: October 2008

AbstractCD59 is a membrane protein inhibitor of the membrane attack complex (MAC) of complement. Humans express only one, whereas mice express two CD59 genes. We previously reported the targeted deletion of the mCd59b gene in which absence of mCd59b together with an unintended down regulation of mCd59a caused hemolytic anemia with spontaneous platelet activation. To confirm the complement role in the hemolytic anemia caused by abrogation of mCd59 function, we have developed a mCd59a and mCd59b double knock out mice and analyzed its phenotype in complement sufficient and deficient (C3−/−). We report here that total abrogation of mCd59 function in mCd59ab−/− mice results in complement‐mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab−/−/C3−/− mice. Am. J. Hematol., 2009. © 2008 Wiley‐Liss, Inc.