bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absence of effect of supplemental oral calcium on ornithine decarboxylase (ODC) activity in colonic mucosae of healthy individuals with a family history of colorectal cancer
Authors: Love Richard R. , Verma Ajit K. , Surawicz Tanya S. , Morrissey John F. 
Published: February 2007

AbstractTissue activity levels of ornithine decarboxylase (ODC) have been suggested to be a marker of colonic epithelial cell proliferation and risk for colorectal cancer. Supplemental dietary calcium has been hypothesized and reported to suppress colonic epithelial‐cell proliferation. We measured sigmoid and rectal mucosal ODC activity levels in 45 healthy, disease‐free subjects with strong family histories of colorectal cancer before and after 2 months, during which daily dietary supplementation with calcium carbonate (to provide 600 mg calcium base) was taken. Although the mean ODC activity levels decreased in both sigmoid and rectal specimens, these changes were small in relation to the standard deviation and were not statistically significant. These data suggest that the magnitude of dietary calcium intake does not significantly influence sigmoid‐rectal mucosal ODC activity levels and that ODC measurements may not be a useful intermediate endpoint for interventions designed to interrupt the colon carcinogenic sequence.
Intralesional cis‐diamminedichloroplatinum and purified collagen treatment of human metastatic malignancies: A feasibility study
Authors: Krag David N. , Théon Alain P. , Schneider Philip D. , Goodnight James E. 
Published: February 2007

AbstractA feasibility study of the treatment of advanced superficial human malignant tumors utilizing direct intralesional injections of cisplatin mixed with purified bovine collagen was performed. The purpose of using intralesional injection of cisplatin mixed with collagen was to limit the drug exposure to normal tissues while increasing the dose and duration of exposure to the tumor. Fourteen evaluable superficial tumors in four patients (melanoma, breast CA, squamous CA from larynx) received a total of 65 treatments in the outpatient clinic setting. All patients had failed prior treatment with systemic intravenous cisplatin. Lesions were treated at least three times at two‐week intervals. After intramuscular meperidine premedication, multiple injections of cisplatin mixed with collagen were made into the tumors. There was minimal normal tissue toxicity and minimal systemic toxicity. Tumor regression or stabilization occurred in 86% (12/14) of tumors; 50% (7/14) of lesions regressed more than 50% in size. This study suggests that intralesional colloidal cisplatin can overcome resistance to systemic intravenous cisplatin.
Postmastectomy locally recurrent breast cancer
Authors: Humphrey L. J. , Moore D. L. , Lytle G. H. 
Published: February 2007

AbstractWith the popularity of breast‐conserving treatment plans, the natural history of “breast recurrence” in the ipsilateral breast must be distinguished from local recurrence following modified radical mastectomy. Hence, this study considers those patients who develop skin or chest wall recurrence after modified radical mastectomy, whether as a primary procedure or for patients with “breast recurrence” after partial mastectomy. The incidence of postmastectomy locally recurrent breast cancer following modified radical mastectomy (MRM) and adjuvant immunotherapy (IT) is compared to historical controls. The risk factors and treatment of local recurrence in this program as well as in a larger group of patients who recurred after modified radical mastectomy are reported.
Long‐term epidural pain relief using a totally implantable access system
Authors: Denobile John , Chester William , Etienne H. Birt , Ghosh Bimal C. 
Published: February 2007

AbstractThe majority of cancer patients at the terminal stage experience pain as a major symptom, and less than 60% of patients receive adequate pain relief. To relieve this symptom we have placed epidural catheters and attached them to an implantable access system. On this method the patients required 0.4–3.5 mg of morphine per hour with occasional boluses. Catheter life span ranged from 15 to 157 days with an average of 57 days.
Occurrence of intestinal metaplasia of the stomach in thai patients with gastritis, benign ulcer, and gastric cancer
Authors: Pongchairerks Paisal , Chalermsanyakorn Panas , Tanjapatkul Mongkol 
Published: February 2007

AbstractPathological sections of gastrectomized specimens of 74 patients with benign gastric ulcer and 79 with gastric cancer were reviewed. Intestinal metaplasia was found in 26 specimens with benign ulcer (35.1%) and in 43 with cancer (54.4%), a difference that is statistically significant. Further analysis of age groups showed that rate of occurrence of metaplasia in cancer patients older than 60 years was 70.3%, which was significantly higher than that of their younger counterparts (40.5%) and of patients with benign ulcer of either age group. A survey was also conducted by taking biopsies of mucosa of antrum and body of the stomach of 250 patients who underwent gastroscopic examinations. Acute and chronic gastritis was found in 22 and 156 patients, respectively. Intestinal metaplasia was found to be associated with acute gastritis in 2 (9.1%) and with chronic gastritis in 25 (16%) patients. In conclusion, intestinal metaplasia was associated with gastric cancer in patients who were older than 60 years in a significantly higher proportion than it was with benign gastric ulcer and gastritis among Thai patients.
Spouse adjustment to cancer surgery: Distress and coping responses
Authors: Keitel Merle A. , Zevon Michael A. , Rounds James B. , Petrelli Nicholas J. , Karakousis Constantine 
Published: February 2007

AbstractAlthough often acknowledged, the impact of the surgical treatment of cancer on the spouse of the adult cancer patient is a largely unexplored area. The present study examined distress, coping, and appraisal among spouses (N = 36) and patients (N = 43) assessed prior to and following surgery. The results indicated that at both the presurgical and postsurgical period, spouses were exhibiting significantly greater distress than patients. Surprisingly, spouses' levels of distress remained fairly constant across the presurgery to postsurgery period, while the patients distress decreased. Escape and avoidance behaviors were found to be maladaptive for spouses coping with their partners' surgical treatment. Appraisal was also found to be a critical factor in understanding individual reactions to the stress of cancer surgery. Spouses of cancer patients undergoing surgical treatment appear to be an underacknowledged population at risk.
Is long‐term follow‐up justified after excision of a thin melanoma (≤ 1.5 mm)?: A retrospective analysis of 206 patients
Authors: Brandt S. E. , Welvaart K. , Hermans J. 
Published: February 2007

AbstractFrom 1964 to 1988, 231 patients underwent local excision as the single treatment of melanoma with a thickness of ≤ 1.5 mm. We investigated the prognostic value of several factors on cancer‐specific survival and cancer‐specific disease‐free survival, from time of excision on, by performing life‐table analysis on 206 evaluable patients. Recurrence developed in 11 patients; local recurrence occurred in four patients, hematogenic spread in three patients and lymph node metastases in another four patients. Six patients died as a result of the disease. Tumors with a thickness of ≤ 1.5 mm have an excellent prognosis regardless of the localization of the melanoma. At 15 years cancer‐specific survival was 92.3% and cancer‐specific disease‐free survival was 86.9%. Recurrence was successfully treated with hope for cure in 4 patients. This figures does not justify aggressive follow‐up for all patients.
Surgical treatment of patients with nonsmall‐cell lung cancer and mediastinal lymph node involvement
Authors: Ishida Teruyoshi , Tateishi Masahiro , Kaneko Satoshi , Sugimachi Keizo 
Published: February 2007

AbstractBetween 1974 and 1988, 115 patients admitted to our surgical unit underwent resection of nonsmall‐cell lung cancer in the presence of mediastinal lymph node involvement (N2 disease). The overall 5 year survival rate was 18%, and the rates in patients with curative and noncurative operation were 26% and 9%, respectively (P < 0.05). Based on the morphological evidence of N2 disease, the patients were placed in three groups: those with microscopic metastasis, moderate metastasis, and gross metastasis, the incidences being 29%, 28%, and 43%, respectively. The survival rates were 41%, 6%, and 16%, respectively. The difference among microscopic vs. moderate and microscopic vs. gross metastasis was statistically significant (P < 0.01). Survival rates in patients with intranodal and extranodal invasion, as seen in the histologic examinations, were 34% and 11%, respectively (P < 0.01). The incidence of gross metastasis and/or extranodal invasion was higher in those who underwent noncurative operation. Postoperatively adjuvant irradiation was not effective in prolonging the survival in patients with curative operation, but the local residual disease was controlled. Therefore, our working criteria are, if N2 lung cancer is present, a complete resection of the primary tumor and the mediastinal lymph nodes should be done. Patients with microscopic metastasis and intranodal invasion can expect a fairly long survival.
A study of cell membrane structure
Authors: Feinmesser R. , Freeman J. L. , Noyek A. , Brama I. , Van Nostrand P. 
Published: February 2007

AbstractNeoplastic transformation has been associated with a variety of structural changes, among which are changes in membrane carbohydrates. Not much is known, though, e.g., how early in the tumourogenic event these changes take place and what effect these changes have on cell growth, invasion, and ability to metastasize. We were able to identify the B‐D‐Gal(1–3)DGal‐NAc as a membrane carbohydrate component present in malignant laryngeal tissue, but not on adjacent normal mucous membrane. This carbohydrate structure was found to be present in metastatic as well as in nonmetastatic tumours. It was also found in well‐differentiated as well as poorly differentiated carcinomas. We suggest that changes in carbohydrate components on the cell membrane of the laryngeal cancer cell are an early event in tumour progression and probably are not related to the degree of invasion or the ability to metastasize.
Primary gastric lymphoma: A prospective analysis of 12 cases and review of the literature
Authors: Sharma Sanjiv , Singhal Sandeep , De Sudershan , Chander S. , Rath G. K. , Misra Anup , Khosla Anil 
Published: February 2007

AbstractThe clinicopathological features of 12 cases of primary lymphoma of the stomach are reviewed, and the efficacy of various treatment modalities is evaluated. The presenting symptomatology and the radiological signs were found to be similar to those of gastric carcinoma. Gastroscopy and computed tomography (CT) proved to be effective diagnostic and staging tools. There were two patients of stage I, seven patients of stage II, and three patients of stage IV. Multimodal therapy involving judiciously combined surgery, radiation therapy, and chemotherapy produced early complete remission in all the nine patients with localized disease, and all of them are disease‐free at a minimum follow‐up period of 12 months. These results are irrespective of whether surgery formed part of the treatment regimen. The relevant literature is reviewed, and the present status of the efficacy of nonsurgical therapy is evaluated.
Intraarterial infusion chemotherapy in regionally advanced malignant melanoma
Authors: Calabro Annamaria , Singletary S. Eva , Carrasco Cesar H. , Legha Sewa S. 
Published: February 2007

AbstractThe therapeutic effectiveness of intraarterial cisplatin (CDDP) and dacar‐bazine (DTIC) infusion was examined in 30 evaluable patients with regionally advanced melanoma that was refractory to standard treatments. Objective responses were achieved in 11 patients (37%), including three complete (10%) and eight partial (27%) tumor regressions. Successful debulking surgery was performed in seven of the eleven patients with response. Six remained free of regional disease after a median time of 25 months, and four are also free of distant metastases at 24+, 25+, 41+, and 54+ months. Nineteen of thirty patients with no significant tumor response underwent alternative treatments. Debulking surgery was performed in nine, but with little palliative gain, since seven relapsed at a median time of 5 months. Our results suggest that a combined therapeutic approach—preoperative chemotherapy followed by surgery in responding tumors—represents an effective treatment for patients with regionally advanced melanoma.
Possible association between gastrectomy and subsequent development of esophageal cancer
Authors: Maeta Michio , Koga Shigemasa , Shimizu Tetsu , Matsui Katsuaki 
Published: February 2007

AbstractTo clarify the possible association between gastrectomy and the subsequent development of esophageal cancer, we studied the incidence of subjective gastroesophageal reflux in 287 patients and analyzed the nutritional status and results of endoscopic examination of the esophagus in 62 patients who had survived for a long period after gastrectomy for nonmalignant diseases. The incidence of postoperative reflux was 22.6%. None of the patients had severe deterioration of blood parameters or nutritional status. Endoscopic observation revealed esophagitis in 24.2% of patients, mainly in the lower esophagus. Histologically, there was a high incidence of infiltration of neutrophils and lymphocytes, enlarged papillae, and basal cell hyperplasia. Epithelial dysplasia was detected in 41.9% of patients, and of these there were more patients in whom the degree of dysplasia was more severe in the lower esophagus than in other areas. These data suggest that postgastrectomy gastroesophageal reflux is more likely than postgastrectomy changes in nutritional status to be a possible contributory factor to the development of subsequent esophageal cancer.
Adrenalectomy for adrenal metastasis from lung carcinoma
Authors: Reyes Luis , Parvez Zafar , Nemoto Takuma , Regal A. ‐M. , Takita Hiroshi 
Published: February 2007

AbstractIn the past 3 years, five patients with lung carcinoma were found to have enlarged adrenal glands without any evidence of distant metastasis. The patients were treated with adrenalectomy. The cases are presented in order to discuss optimal methods of diagnosis and treatment for this condition.
Early and late complications of totally implantable venous access devices
Authors: Grannan Kevin J. , Taylor Philip H. 
Published: February 2007

AbstractWe reviewed the records of 66 consecutive patients who underwent placement of totally implantable venous access devices (TIVADs). Fourteen patients (21%) experienced complications related to the TIVAD. Complications included hematoma, infection, pneumothorax, subclavian vein thrombosis, and chronic clavicular pain. The 1 month mortality rate following insertion of a TIVAD was 24% (16 of 66 patients); however, none of the patients died as a direct consequence of port insertion or its associated complications. Overall patient and physician acceptance of TIVADs was good, and we encourage continued use and study of this device.
Pituitary apoplexy following coronary artery bypass surgery
Authors: Shapiro Lorie M. 
Published: February 2007

AbstractPituitary apoplexy is a syndrome with variable clinical manifestations depending on which parasellar structures (such as the optic nerves and chiasm, cavernous and sphenoid sinuses, or the hypothalamus) are compressed when the pituitary undergoes rapid enlargement. Factors associated with cardiopulmonary bypass that may lead to pituitary apoplexy include ischemia, hemorrhage, edema, and positive pressure ventilation. Seven cases of pituitary apoplexy following cardiopulmonary bypass have been reported, including the present case. Transsphenoidal surgical decompression in the present case and those previously reported appears to be safe after cardiac surgery and may be helpful in amelioration of compression of nearby structures. Pituitary apoplexy should be considered as a diagnostic possibility in patients who develop visual disturbances or ophthalmoplegia following open heart surgery.
Observations on the natural history and treatment of recurrent major salivary gland cancer
Authors: Armstrong John G. , Harrison Louis B. , Spiro Ronald H. , Fass Daniel E. , Strong Elliot W. , Fuks Zvi Y. 
Published: February 2007

AbstractIn an attempt to define the natural history and the indications for postoperative radiotherapy (RT) in locally recurrent major salivary gland cancers, we reviewed 78 patients treated between 1965 and 1982. All patients underwent resection of the tumor. Group 1 (N = 38) had complete resection of tumors, with low or intermediate grade histology and without lymph node spread. Group 2 consisted of the remaining 40 patients who had high‐risk features (HR) (high grade histology, lymph node metastases, and close or positive margins of resection). Half of the Group 2 patients received radiation therapy. Overall survival was 63% at 5 years, and 35% at 15 years. Survival of Group 1 was 83% at 5 years and 58% at 15 years. Local control for Group 1 was 69% at 5 years, 54% at 15 years, and was size‐dependent. Group 2 survival was 40% at 5 years and 29% at 10 years. Local control at 5 and 10 years was 49% and 35%. Our data indicate that surgery alone yielded good local control in patients with small tumors (≦ 3 cm) and no HR features, suggesting that postoperative RT may be unnecessary for these patients. Other patients have suboptimal local control, and although there is a rationale for the use of postoperative radiotherapy, we cannot assess its impact in this retrospective study.
Natural history and selective management of in transit melanoma
Authors: Wong Jan H. , Cagle Leslie A. , Kopald Kelly H. , Swisher Stephen G. , Morton Donald L. 
Published: February 2007

AbstractNinety five patients who developed in transit melanoma either as their initial site of recurrent melanoma or following regional node metastases were retrospectively reviewed. In transit melanoma occurred most frequently on the lower extremity and appeared to be associated with deeply invasive primary tumors. The median time to development of in transit melanoma was 16 months. Eighty‐two (86%) of these patients have progressed to systemic disease from 2 to 244 months (median 16 months) following the development of in transit melanoma, and 72 (79%) died (median survival 19 months). Survival appears to correlate with the extent of in transit melanoma and with the disease‐free interval. These findings suggest that in transit melanoma represents an early manifestation of systemic disease, warranting careful clinical follow‐up and perhaps systemic treatment, when effective therapy becomes available. However, some patients will respond to local immunotherapy, surgical excision, and isolated limb perfusion and will enjoy significant length and quality of life. This sequential approach remains the treatment of choice for this manifestation of metastatic melanoma.
Radiation therapy in the treatment of cervical Cancer: The university of Chicago/Michael reese hospital experience
Authors: Rader Janet S. , Haraf Daniel J. , Halpern Howard J. , Rotmensch Jacob , Spelbring Danny R. , Sutton Harold , Javaheri Godratollah , Weichselbaum Ralph R. 
Published: February 2007

AbstractA retrospective analysis was conducted on 307 patients referred for radiation therapy at The University of Chicago and Michael Reese Hospital between 1971 and 1986. Median follow‐up was 6.4 years. Treatment techniques varied during the time of the study. Actuarial disease‐free survivals were 78%, 64%, 55%, 33%, 41%, and 60% for stage IB, IIA, IIB, IIIA, IIIB, and IVA, respectively. Stage, size of the cervical lesion, and hemoglobin level during treatment were prognostic factors. Treatment technique as well as time dose factors were analyzed with respect to survival, failures, and complications.
Stomal recurrence: A separate entity?
Authors: Barr Gerald D. , Robertson A. G. , Liu K. C. 
Published: February 2007

AbstractUncertainty exists concerning the exact aetiology of stomal recurrence following laryngectomy, although it is generally agreed that, when present, the prognosis is very poor. Fourteen cases of stomal recurrence were compared with 15 cases of other types of aggressive recurrence in the neck, for factors implicated in stomal recurrence. Similarities exist between the two groups and, although stomal recurrence has a greater association with subglottic tumour, this difference is not statistically significant. The possible mechanisms of recurrence are discussed, particularly in relation to aggressiveness, and it is concluded that factors involved in aggressive recurrences are similar. Stomal recurrence can be considered part of a group of aggressive neck recurrences associated with more advanced disease prior to laryngectomy.
Cancer of the male breast
Authors: Morimoto Tadaoki , Komaki Kansei , Yamakawa Takashi , Tanaka Takashi , Oomine Yuken , Konishi Yasunoki , Mori Toshiaki , Monden Yasumasa 
Published: February 2007

AbstractThe purpose of this study was to investigate the biological behavior of male breast cancer. We evaluated 11 cases of male breast cancer with respect to tumor growth, extent of disease, hormone receptor status, and histological grade of the malignancy, in comparison with 241 cases of female breast cancer. The duration of symptoms was 8.6 ± 9.1 months in males and 8.5 ± 18.6 months in females. The incidences of stages I, II, and III were 46%, 27%, and 27%, respectively, in male breast cancer, and 38%, 49%, and 13% in female breast cancer. Metastasis to the lymph node was negative in 60% of the male patients and 54% of the female patients. All cases of male breast cancer were histologically grade I according to Bloom's classification; the histological grades were as follows for the female breast cancer cases: grade I in 99 patients, grade II in 87, and grade III in 55. The rates of hormone receptor positively were 89% for ER and 86% for PgR in male breast cancer, and 64% for ER and 44% for PgR in female breast cancer. Therefore, there was no significant difference in the growth of male breast cancer and female breast cancer, but in male breast cancer the rate of hormone receptor positivity was high, endocrine therapy was effective, and the histological grade was low. Accordingly, the result following appropriate treatment of male breast cancer should be at least comparable to the results with female breast cancer.