bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sedimentary characteristics and evolution of the Upper Permian Wujiaping Formation in the eastern Yangtze Block
Authors: Wang Yuanchong , Li Hao , Mou Chuanlong , Chen Weiwei , Gao Chang , Liang Wei , Zheng Binsong , Hou Qian , Xia Yu 
Published: March 2024

Abstract
The Upper Permian Wujiaping (WJP) Formation in the Yangtze Block (Southern China) has been proven of great potential for shale gas exploration. However, the sedimentary characteristics and environment evolution of WJP Formation is poorly understood. Based on 260 hand specimen samples obtained from 18 sections and 1 borehole in eastern Yangtze Block, petrographic observation reveals that the WJP Formation is composed of ten kinds of rock types. Combining with analyses of geochemistry compositions, the sedimentary facies belts of the WJP Formation are divided into shoreland, shallow-water shelf, deep-water shelf, and shoal. Bauxite was developed in the shoreland at the bottom of the WJP Formation, which is attributed to the Dongwu Movement. The formation of paleo-uplift exerted significant effect on palaeogeomorphology and led to major change of the sedimentary model from underlying stratum to WJP Formation. During the lower WJP Formation sedimentary period, gradual transgression occurred in the eastern Yangtze Block. Shoreland, shallow-water shelf, and deep-water shelf were developed northward in turn. In the period of the upper WJP, the area of the deep-water shelf was expanded due to durative transgression. A few patched shoals formed on the shallow-water shelf.
Dynamics analysis and parameter optimization of a nonlinear energy sink with geometrically nonlinear inerters
Authors: Jiawen Chu , Jingjun Lou , Chai kai 
Published: March 2024

Abstract

This paper studies a nonlinear energy sink (NES) with geometrically nonlinear inerters (GNI-NES) to improve the vibration absorption performance. The force-displacement relation of the geometrically nonlinear inerters mechanism (NIM) is obtained, and a dynamic model is established for the coupled system. The dynamic responses of the system are solved using the harmonic balance method (HBM) and the Runge-Kutta method. The vibration absorption performance of the system is evaluated using displacement transmissibility, and the parameters are analyzed. Then, the grey wolf algorithm is used to obtain the optimal system parameters. The results show that compared with the cubic NES, the proposed GNI-NES achieves the lower peak value, and exhibits better vibration stability compare to the cubic NES. Furthermore, these outcomes enhance our comprehension of the operations of the NIM and aid in crafting more effective designs of nonlinear passive vibration mitigation systems employing inerters.
Dumbbell probe-based colorimetric and sensitive detection of miRNA during postoperative care of gastric cancer by using polymerase/endonuclease assisted chain displacement
Authors: Xu Xialing , Zhang Ping , Tao Siyu 
Published: March 2024

Abstract
Methods for sequence-specific microRNA (miRNA) analysis that are both simple and quick to implement are crucial for miRNA research and guiding nursing strategies. We have devised a colorimetric technique for detecting miRNA using a d dumbbell probe-based polymerase/endonuclease assisted chain displacement, along with silver ions (Ag+) aptamer assisted color reaction. This method utilizes the hairpin structure in the dumbbell probe to significantly enhance the accuracy of target recognition in the polymerase/endonuclease assisted chain displacement strategy. As a result, the method gains a superior capability to discriminate between target miRNA and interfering miRNAs. The combination of target recycling and the polymerase/endonuclease assisted chain displacement strategy allows for highly sensitive analysis of miRNA, which is either superior or comparable to previous colorimetric methods for miRNA detection. Hence, the suggested approach enables precise measurement of miRNA-21 within the concentration range of 100 fM to 5 nM, with a low detection limit of 45.32 fM. Additionally, it exhibits exceptional capability in distinguishing variations at the level of individual nucleotides. Furthermore, the detection technique may be utilized to precisely measure the amount of miRNA-21 in serum samples, demonstrating a high level of concordance with the findings obtained from a commercially available miRNA detection kit. This approach is simple, economical, and extremely specific for detecting miRNA. It holds great potential for clinical use, particularly in guiding the adaptation of nursing techniques.
Safety and surgical outcomes of robotic adrenalectomy: a 15-year experience at a single institution
Authors: Kim Kwangsoon , Park Dawon , Oh Moon Young , Chai Young Jun , Kim Hoon Yub 
Published: March 2024

Abstract
Robotic adrenalectomy (RA) has gained significant popularity in the management of adrenal gland diseases. We report our experience at a single tertiary institution and evaluate the safety and surgical outcomes of RA. The data of 122 consecutive patients who underwent RA from October 2009 to December 2022 at Korea University Anam Hospital (Seoul, Korea) were reviewed. Clinicopathological features and surgical outcomes were retrospectively analyzed through complete chart reviews. Noteworthy findings include the influence of sex, tumor size, and body mass index on operation time, with the female and small tumor groups exhibiting shorter operation times (P = 0.018 and P = 0.009, respectively). Pheochromocytoma was identified as a significant independent risk factor for a longer operation time in the multivariate analysis (odds ratio[OR], 3.709; 95% confidence interval [CI], 1.127–12.205; P = 0.031). A temporal analysis revealed a decreasing trend in mean operation times across consecutive groups, reflecting a learning curve associated with RA adoption. RA is a safe and effective operative technique alternative to laparoscopic adrenalectomy that has favorable surgical outcomes and enhances the convenience of the operation.
Supplementation of Acacia dealbata versus Acacia mearnsii leaf-meal has potential to maintain growth performance of lambs grazing low-quality communal rangelands in South Africa
Authors: Mushunje Lovelyn Hellen , Marandure Tawanda , Chikwanha Obert Chenjerai , Bennett James , Hawkins Heidi , Palmer Antony , Wu Lianhai , Marufu Munyaradzi , Mapiye Cletos 
Published: March 2024

Abstract

Supplementing livestock grazing communal rangelands with leaf-meals from Acacia trees, which are currently considered as problematic invasive alien plants globally, may be a sustainable way of exploiting their desirable nutritional and anthelmintic properties. The current study evaluated worm burdens and growth performance of lambs grazing low-quality communal rangelands supplemented with leaf-meals prepared from the invasive alien plant species; Acacia mearnsii or A. dealbata. Forty, three-month-old ewe lambs weighing an average of 18.9 ± 0.60 kg were randomly allocated to four supplementary diets: (1) rangeland hay only (control), (2) commercial protein supplement plus rangeland hay, (3) A. mearnsii leaf-meal plus rangeland hay and (4) A. dealbata leaf-meal plus rangeland hay. All the supplementary diets were formulated to meet the lambs’ minimum maintenance requirements for protein. All the lambs were grazed on communal rangelands daily from 0800 to 1400 after which they were penned to allow them access to their respective supplementary diets until 08:00 the following morning. The respective supplementary diets were offered at the rate of 400 g ewe− 1 day− 1 for 60 days. Lambs fed the commercial protein supplement had the highest dry matter intake followed by those fed the Acacia leaf-meals and the control diet, respectively (P ≤ 0.05). Relative to the other supplementary diets, lambs fed the commercial protein supplement and A. dealbata leaf-meal had higher (P ≤ 0.05) final body weight and average daily gains. Dietary supplementation did not affect lamb faecal worm egg counts over the study period (P > 0.05). There was no association between supplementary diets and lamb FAMACHA© scores (P > 0.05). It was concluded that the Acacia dealbata relative to Acacia mearnsii has potential to maintain growth performance of lambs grazing communal rangelands in the dry season.
Structural Equation Modeling Analysis of Factors Influencing decisional conflict between dialysis modality among end-stage kidney disease patients in Wuhan
Authors: Zhang shiyi , Cui jinrui , Liu xiaoqin , He xifei , Xu yulin 
Published: March 2024

Abstract

Objectives: To explore the influencing factors and relationships associated with decisional conflict of dialysis modality in ESKD patients.
Methods: This study was a survey-based cross-sectional investigation conducted on 150 ESKD patients in a third-class hospital in Wuhan. The general information questionnaire, decisional conflict scale, Montreal cognitive assessment, frail scale, perceived social support scale, and brief health literacy screen were used for investigation. SPSS 25.0 was used to compare the differences between the decisional and non-decisional conflict groups, and AMOS 23.0 was used to construct a structural equation model to explore the influencing factors.
Results:The incidence of decisional conflict in 150 ESKD patients was 33.3% (50/150). Binary logistic regression analysis showed that the independent risk factors for decisional conflict of dialysis modality in ESKD patients included monthly household income (OR = 0.184), cognitive function (OR = 7.0), social support (OR = 0.891), health literacy (OR = 0.608), the level of eGFR (OR = 1.488), and the level of cTnI (OR = 9.558). The constructed path analysis model had a good fit (x2/df = 1.499, GFI = 0.957, AGFI = 0.911, NFI = 0.906, CFI = 0.967, RMSEA = 0.055). The path analysis showed that health literacy (0.577) had the greatest impact on the decisional conflict, with a direct effect of 0.480 and an indirect effect of 0.097 through cognitive function and monthly household income. Next was social support with an effect value of 0.434.
Conclusions:In clinical practice, it is important to enhance the health literacy of patients and their families and to provide advance education on dialysis plans. Additionally, in managing and planning chronic kidney disease progression and dialysis, it is recommended to regularly and systematically assess cognitive function, particularly before the patient's cognitive impairment worsens or the severity of the disease progresses. Advance care planning can be established through collaboration between healthcare professionals and patients to ensure appropriate decision-making and management.
Implications for the profession and/or patient care：This paper finds that the influencing factors and their relationships of dialysis methods in end-stage renal disease patients,helping nurses better exercise autonomy, helping patients reduce their decisional conflict , improving clinical outcomes.
Patient or Public Contribution： Patients received a relevant questionnaire survey, and caregivers assisted in conducting the survey.
Can the Pan-immune-inflammation Value Predict Gram Negative Bloodstream Infections-related 30-day Mortality in Solid Organ Transplant Recipients?
Authors: Ayaz Caglayan Merve , Turhan Özge , Yılmaz Vural Taner , Adanır Haydar , Sezer Beyza , Öğünç Dilara 
Published: March 2024

Abstract
Background: The recently used pan-immune-inflammation value (PIV) has not been adequately studied as a predictive marker for mortality in immunosuppressed patients. The aim of this study was to evaluate the usefulness of baseline PIV level as a predictor of 30-day mortality in solid organ transplant (SOT) recipients with gram negative bloodstream infections (GN-BSI).
Methods: This retrospective, cross-sectional study was conducted between January 1, 2019, and December 31, 2022, in 1104 SOT recipients. During the study period, 118 GN-BSI were recorded in 113 patients. Clinical, epidemiological, and laboratory data were collected, and mortality rates (30-day and all-cause) were recorded.
Results: The 113 recipients had a median age of 50 years [interquartile range (IQR) 37.5-61.5 years] with a male predominance (n=72, 63.7%). The three most common microorganisms were as follows: 46 isolates (38.9%) of Escherichia coli, 41 (34.7%) of Klebsiella pneumoniae, and 12 (10.2%) of Acinetobacter baumannii. In 44.9% and 35.6% of the isolates, production of extended-spectrum beta-lactamases and carbapenem resistance were detected, respectively. The incidence of carbapenem-resistant GN-BSI was higher in liver recipients than in renal recipients (n=27, 69.2% vs n=13, 17.6%, p<0.001). All-cause and 30-day mortality rates after GN-BSI were 26.5% (n=30), and 16.8% (n=19), respectively. In the group with GN-BSI-related 30-day mortality, the median PIV level was significantly lower (327.3, IQR 64.8-795.4 vs. 1049.6, IQR 338.6-2177.1; p= 0.002). The binary logistic regression analysis identified low PIV level [hazard ratio (HR)=0.93, 95% confidence interval (CI) 0.86-0.99; p= 0.04], and increased age (HR=1.05, 95% CI 1.01-1.09; p= 0.002) as factors associated with 30-day mortality. The receiver operating characteristic analysis revealed that PIV could determine the GN-BSI-related 30-day mortality with area under curve (AUC): 0.723, 95% CI 0.597-0.848, p = 0.0005.
Conclusions: PIV is a simple and inexpensive biomarker that can be used to estimate mortality in immunosuppressed patients, but the results need to be interpreted carefully.
Temperature-based protection of biochemical and biomechanical characteristics during 25 kGy 60Co irradiation for allograft tendons
Authors: Wan Yanlin , Liu Dayong , Wang Xiaolong , Wang Limin , Ma Rongxing , Jiang Zhao , Li Wenjing , Gao Bing , Zhang Jingyu , Hu Yongcheng 
Published: March 2024

Abstract
Background: Nowadays, there is a lack of effective treatment for reducing damage to the collagen proteins in tendons during the gamma irradiation process. We aim to investigate different temperatures on the protection of allogeneic tendons during 25kGy 60Co gamma irradiation.
Methods: Based on different temperatures during irradiation, twenty-four allogeneic tendons were divided into groups of -70 °C, 0 °C, and room temperature (RT). The arrangement and spatial structure of collagen fibers were observed by HE and Masson staining, polarizing microscope after Sirius Red staining was used to observe collagen curl periods, damaged collagen protein was assessed using free hydroxyproline tests. Tensile fracture and cyclic loading tests were performed, then calculated the elastic modulus, maximum stress, maximum strain, strain energy density, and cyclic creep strain.
Results: In the -70 °C group, the structure and morphology of collagen fibers were significantly better than in the 0 °C group. At -70 ºC the damaged collagen was the lowest, with 46.27 and 50.03% improvement compared to that at 0ºC (P = 0.016) and RT (P < 0.004). The maximum stress of -70 °C (68.19 ± 30.11 MPa) is superior to that at 0 °C (36.58 ± 12.00 MPa) and RT (41.27 ± 16.34 MPa).
Conclusions: Cryogenic temperature has a protective effect on allograft tendons at 25kGy gamma radiation, and -70 °C provides better protection than 0 °C
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein
Authors: Loock Marnix Van , Damme Ellen Van , Abeywickrema Pravien , Yin Yanting , Xie Jiexiong , Jacobs Sofie , Mann Mandeep , Miller Robyn , Piassek Madison , Doijen Jordi , Marsili Simone , Subramanian Murali , Gottlieb Leah , Abdelnabi Rana , Gool Michiel Van , Broeck Nick Van den , De Pauw Ines , Scobey D. , Mattocks Melissa , Schaefer Alexandra , Jochmans Dirk , De Jonghe Steven , Leyssen Pieter , Chiu Winston , Toro Mayra Diosa , Zwaagstra Marleen , Leijs Anouk , de Gruyter Heidi , Buyck Christophe , Heede Klaas van den , Jacobs Frank , Eynde Christel Van den , Thijs Laura , Raeymaekers Valerie , Miller Seth , Rosario Amanda , Neyts Johan , Baric Ralph , Kuppeveld Frank van , Snijder Eric , Hemert Martijn van , Monshouwer Mario , Sharma Sujata , Draghia-Akli Ruxandra , Koul Anil , Diels Annick , Vermeulen Peter , Temmerman Koen , Peeters Danielle 
Published: March 2024

Abstract
The membrane (M) protein of betacoronaviruses is well-conserved and plays a key role in viral assembly. Here, we describe the discovery of JNJ-9676, a novel small molecule targeting the coronaviral (CoV) M protein. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV2, SARS-CoV, and sarbecovirus strains from bat and pangolin zoonotic origin. Using cryogenic electron microscopy, we determined a novel binding pocket of JNJ-9676 in the M protein's transmembrane domain. Compound binding stabilized the M protein in an altered conformational state between its long- and short-forms, preventing the release of infectious virus. In a pre-exposure Syrian golden hamster model, JNJ-9676 (25 mg/kg BID) showed excellent efficacy illustrated by a significant reduction in viral load and infectious virus in the lung by 3.5 log10 and 4 log10, respectively. Histopathology scores at this dose were reduced to baseline. In a post-exposure hamster model, JNJ-9676 was efficacious at 75mg/kg BID even when added at 48 h post-infection, when peak viral loads were observed. The M protein is an attractive novel antiviral target to block coronavirus replication with JNJ-9676 representing an interesting chemical series towards identifying clinical candidates addressing the current and future CoV pandemics.
The variations of five Colletotrichum strains from strawberry in mycelial growth and pathogenicity below 26℃
Authors: Li Xue , Geng Chunnu , Huang Xianyao , Chen Siyu , Yang Jing , Han Yongchao , Lu Fangyan , Duan Ke , Gao Qinghua 
Published: March 2024

Abstract

Anthracnose caused by Colletotrichum spp. is a serious threat to many crops. C. siamense has been increasingly prevalent recently. However, the biology and pathogenicity of these fungi was largely elusive, especially below 26°C. Currently, the mycelial growth of five representative Colletotrichum strains including three C. siamense, one C. fructicola and one C. gloeosporioides s.s. strain from diseased strawberry was characterized at 10, 14, 18, 22 and 26℃. Their pathogenicity to two hosts under 14℃ and 22℃ was investigated. These strains did not differ much in mycelium growth between 10–26℃, although all C. siamense and C. gloeosporioides s.s. strains showed some superiority than C. fructicola. However, great variations were observed in their pathogenicity to Fragaria vesca and F. × ananassa cv. ‘Benihoppe’. The strain Cs:GQHZJ19 with fastest mycelial growth at 22℃ was also the most virulent to both hosts under 14 / 22℃. But the mycelial growth rate was only positively correlated with C. siamense pathogenicity to the susceptible cv. ‘Benihoppe’ at 3 dpi under 22℃. Based on the pathogenicity analysis for five Colletotrichum strains on hosts with varying susceptibility under distinct temperatures, this work suggested that host genotype might play a decisive role in disease severity from the beginning of infection, while temperature could shape host-Colletotrichum spp. interaction at a later infection stage. Future studies with more fungal samples are required to determine the biology and virulence of Colletotrichum strains (especially C. siamense) in a wider temperature range, which will eventually facilitate an effective management of crop anthracnose.
Effect of serum uric acid on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions
Authors: Gao Hongjie , Liu Dongchao , Xue Zheng , Qi Jingxian , Yin Liang , Duan Bing , Wu Lin , Yang Kun , Gao Bulang , Cao Qinying , Mi Jie 
Published: March 2024

Abstract

Purpose
To investigate the effect of hyperuricemia on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions.
Materials and methods
Patients with coronary bifurcation lesions treated with drug-eluting stent implantation were retrospectively enrolled. The clinical, interventional and follow-up data were analyzed.
Results
Totally, 193 patients were enrolled, including 59 with hyperuricemia and 134 without hyperuricemia. Serum triglyceride (1.73 vs. 1.44 mmol/L) and creatinine (70.0 vs. 61.0µmol/L) levels were significantly (P < 0.05) higher in the hyperuricemia than in the non-hyperuricemia group. During follow-up, seven patients died, including one (14.3%) death in the hyperuricemia and six (85.7%) in the non-hyperuricemia group. Twelve patients experienced revascularization, including 5 (41.7%) in the hyperuricemia group and 7 (58.3%) in the non-hyperuricemia group. Seventy patients were readmitted to the hospital because of cardiac reasons, including 36 (51.4%) patients in the hyperuricemia and 34 (48.6%) in the non-hyperuricemia group. The risk of cardiac readmission was significantly (P < 0.001) greater in the non-hyperuricemia than in the hyperuricemia group (30.10 vs. 24.33 m). Age was a significant (P = 0.01) independent risk factor for all-cause mortality after cardiac intervention with a hazard ratio (HR) of 1.12 (95% CI 1.03–1.23). Diabetes mellitus was the only significant (P = 0.007) independent risk factor for revascularization, with a HR of 5.13 (95% CI 1.56–16.91). Male sex (P = 0.023, HR 2.21 with 95% CI of 1.12–4.38), total cholesterol (P = 0.004, HR 2.53 with 95% CI 1.35–4.74), and hyperuricemia (P = 0.001, HR 2.37 with 95% CI 1.44–3.89) were significant independent risk factors for cardiac readmission.
Conclusion
Hyperuricemia is an independent risk factor for cardiogenic readmission rather than for all-cause mortality and revascularization after drug-eluting stent implantation for patients with coronary bifurcation lesions.
Numerical simulation of potential impulse waves generated by Mogu rock landslide at varying water levels in Lianghekou Reservoir, China
Authors: Chen Shizhuang , Xu Weiya , Zhang Guike , Wang Rubin , Yan Long , Zhang Hailong , Wang Huanling 
Published: March 2024

Abstract
Reservoir impoundment and water level fluctuations often trigger landslides and their secondary disasters, such as potential impulse waves, posing a serious threat to the safety of people along the reservoir and dam areas, causing economic losses and even catastrophic consequences. This study delves into a comprehensive field investigation and monitoring of the engineering geological conditions and deformation mechanisms the Mogu rock landslide. Impoundment is identified as the primary factor inducing slope deformation, with the cumulative displacement of the sliding body showing no signs of convergence, indicating potential instability. By coupling the elasto-visco-plasticity model and the RNG turbulence model in FLOW3D, an actual surge disaster near the Lianghekou Reservoir dam area is replicated to validate the reliability of the numerical method. Building upon this, a three-dimensional model is established to calculate potential impulse waves generated by the Mogu rock landslide, and the risk to the dam is evaluated. Under varying water level conditions, the simulated heights of impulse waves do not surpass the dam elevation, demonstrating a satisfactory safety margin. Given the inherent danger of landslide-induced wave disasters, continuous attention is warranted, and preventive measures and suggestions are proposed to address these concerns. Additionally, the study explores the contributions of water level fluctuations to the primary wave height, the maximum run-up on the opposite bank and the dam, and the attenuation rate of wave height along the river channel. The results provide significant reference values for the early warning and prevention of comparable reservoir landslides and potential landslide-induced waves worldwide.