bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Calcium, Calcitriol, and Alendronate in Corticosteroid-Treated Premenopausal Patients with Systemic Lupus Erythematosus
Authors: YEAP SWAN S. , FAUZI AHMAD R. , KONG NORELLA C.T. , HALIM ABDUL G. , SOEHARDY ZAINUDIN , RAHIMAH ISMAIL , CHOW SOOK K. , GOH EMILY M.L. 
Published: November 2008

ObjectiveTo assess bone mineral density (BMD) changes in patients with systemic lupus erythematosus (SLE) undergoing longterm therapy with corticosteroids (CS) while taking calcium, calcitriol, or alendronate. The primary endpoint was BMD changes at 2 years.MethodsPremenopausal SLE patients were randomized into 3 groups according to medication: calcium carbonate 500 mg bd (calcium alone), calcitriol 0.25 μg bd plus calcium carbonate 500 mg bd (calcitriol + calcium), and alendronate 70 mg/week plus calcium carbonate 500 mg bd (alendronate + calcium). BMD was measured at baseline and at the end of the first and second years.ResultsNinety-eight patients were recruited. There were 33 patients taking calcium alone, 33 calcitriol + calcium, and 32 alendronate + calcium. On randomization, median duration of CS use was 2.5 years (range 0–20 yrs). Seventy-seven patients (78.6%) completed the study (23 taking calcium alone, 27 calcitriol + calcium, 27 alendronate + calcium). There were no significant differences in mean CS dosages among the 3 groups at the time of BMD measurements. After 2 years, there were no significant changes in BMD in the calcium-alone and calcitriol + calcium groups, apart from a 0.93% (p < 0.001) reduction in total hip BMD in the calcium-alone group. In contrast, the alendronate + calcium group showed significant increases in BMD of 2.69% (p < 0.001) in the lumbar spine and 1.41% (p < 0.001) in total hip.ConclusionBoth calcium alone and calcitriol + calcium preserved lumbar spine BMD in premenopausal patients with SLE taking longterm CS at 2 years, whereas alendronate + calcium led to increases in BMD in lumbar spine and total hip. Premenopausal women taking CS should be considered for osteoporosis prophylaxis.
Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study
Authors: NEOGI TUHINA , ELLISON R. CURTIS , HUNT STEVEN , TERKELTAUB ROBERT , FELSON DAVID T. , ZHANG YUQING 
Published: November 2008

Objective.To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors.Methods.The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound. We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia.ResultsIn total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women.Conclusion.In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men.
Carbon Coated Fe3O4 Nanospindles as a Superior Anode Material for Lithium‐Ion Batteries
Authors: Zhang Wei‐Ming , Wu Xing‐Long , Hu Jin‐Song , Guo Yu‐Guo , Wan Li‐Jun 
Published: November 2008

AbstractCarbon‐coated Fe3O4 nanospindles are synthesized by partial reduction of monodispersed hematite nanospindles with carbon coatings, and investigated with scanning electron microscopy, transmission electron microscopy, X‐ray diffraction, and electrochemical experiments. The Fe3O4C nanospindles show high reversible capacity (∼745 mA h g−1 at C/5 and ∼600 mA h g−1 at C/2), high coulombic efficiency in the first cycle, as well as significantly enhanced cycling performance and high rate capability compared with bare hematite spindles and commercial magnetite particles. The improvements can be attributed to the uniform and continuous carbon coating layers, which have several functions, including: i) maintaining the integrity of particles, ii) increasing the electronic conductivity of electrodes leading to the formation of uniform and thin solid electrolyte interphase (SEI) films on the surface, and iii) stabilizing the as‐formed SEI films. The results give clear evidence of the utility of carbon coatings to improve the electrochemical performance of nanostructured transition metal oxides as superior anode materials for lithium‐ion batteries.
Johanson–Blizzard syndrome caused by identicalUBR1mutations in two unrelated girls, one with a cardiomyopathy
Authors: Elting Mariet , Kariminejad Ariana , de Sonnaville Marie‐Louise , Ottenkamp Jaap , Bauhuber Susanne , Bozorgmehr Bita , Zenker Martin , Cobben Jan M. 
Published: November 2008

AbstractWe report on two apparently unrelated girls with Johanson–Blizzard syndrome (JBS), in both children caused by a homozygous IVS26 + 5G>A mutation in theUBR1gene. In both cases the parents are consanguineous and more sibs are affected. The somewhat mild phenotype (with no or slight mental retardation) in these two JBS families might be explained by residual UBR1 activity. One case has a dilated cardiomyopathy, a symptom only rarely reported in JBS, but of important clinical significance. © 2008 Wiley‐Liss, Inc.
A report of an apparent new genetic syndrome consisting of joint contractures, keloids, large optic cup‐to‐disc ratio and renal stones
Authors: Heyen Candy A. , Delk Paula R. , Bull Marilyn J. , Weaver David D. 
Published: November 2008

AbstractWe report on a family with an apparently undescribed syndrome involving joint contractures, keloids, an increased optic cup‐to‐disc ratio, and renal stones. The propositus presented at 9 years of age with congenital contractures of his distal interphalangeal (DIP) joints, progressive stiffness of the shoulders and neck, a large optic cup‐to‐disc ratio, and mildly dysmorphic facies. He otherwise has been normal. The propositus's brother, uncle, great‐uncle, a half great‐uncle, and six male half‐cousins once removed also have DIP joint stiffness. The propositus' mother and brother also have an increased optic cup‐to‐disc ratio. In addition, the great‐grandfather, the uncle, the same six male half‐cousins once removed, and an affected daughter of a half‐cousin have keloids with the earliest age of onset of the keloids being 12 years. Further, three of the above affected males have had uric acid renal stones. Dupuytren contractures and subcutaneous nodules were also present in some affected males. Given the family history, the pattern of inheritance appears to be X‐linked. An extensive literature search failed to reveal any previous reports associating these manifestations and this inheritance pattern. Therefore, we think the condition in this family comprises a new genetic syndrome. © 2008 Wiley‐Liss, Inc.
Stochastic simulation for morphological development during the isothermal crystallization of semicrystalline polymers: A case study of syndiotactic polypropylene
Authors: Anantawaraskul Siripon , Ketdee Saraporn , Supaphol Pitt 
Published: November 2008

AbstractA stochastic simulation scheme for predicting morphological development during nucleation and subsequent crystal growth based on predetermined crystallization kinetic data of a semicrystalline polymer under quiescent isothermal conditions is proposed. Based on previously obtained crystallization kinetic data for syndiotactic polypropylene (s‐PP) used as the input information, the simulation scheme was successful in predicting the morphological development of s‐PP during isothermal crystallization from the melt state. The predicted development of crystallinity during crystallization was reanalyzed with the Avrami macrokinetic model, and good agreement between the predicted and theoretical values for s‐PP was observed. On the basis of this simulation scheme, both the spherulite size and its distribution during the course of crystallization could also be predicted. Although the spherulitic growth rate influenced both the spherulite size and its distribution during the course of crystallization, it had no effect on the final spherulitic morphology or the resulting average spherulitic size. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Leishmanicidal Evaluation of Novel Synthetic Chromenes
Authors: Alizadeh Babak Heidary , Foroumadi Alireza , Ardestani Susan K. , Poorrajab Fatemeh , Shafiee Abass 
Published: November 2008

AbstractIn the present paper, twelve chromenes were synthesized by coupling of 2,2,8,8‐tetramethyl‐8H‐pyrano[2,3‐f]chroman‐4‐one 1 with various aryl and benzylmagnesium chlorides. The synthetic compounds were examined for in‐vitro activity against Leishmania major, and some of them displayed efficient anti‐leishmanial activity. Among the compounds tested, compounds 9 (4‐(2‐chloro‐benzylidene)‐2,2,8,8‐tetramethyl‐3,4‐dihydro‐2H,8H‐pyrano[2,3‐f]chromene 9a and 4‐(2‐chloro‐benzyl)‐2,2,8,8‐tetramethyl‐2H,8H‐pyrano[2,3‐f]chromene 9b) were the most active with an inhibitory activity of 73.4%.
“Half‐Bonds” in an Unusual Coordinated S42− Rectangle
Authors: Poduska Anne , Hoffmann Roald , Ienco Andrea , Mealli Carlo 
Published: November 2008

AbstractDon′t be square! A rare S42− rectangle bridging two M2Cp2(μ2‐CH2)2 (M=Rh, Ir) fragments is found to contain two “half‐bonds” with SS distances of 2.70 or 2.90 Å. Computational studies explore the connection between these “half‐bonds” and a Jahn–Teller distortion, as well as possible intermediates that form M4S42+ clusters having the S42− rectangle rotated by 90°.magnified imageThe bonding of a rare S42− rectangle coordinated to four transition metals (synthesized by Isobe, Nishioka, and co‐workers), [{M2(η5‐C5Me5)2(μ‐CH2)2}2(μ‐S4)]2+ (MRh, Ir) is analyzed. DFT calculations indicate that, while experiment gives the rectangle coordinated with its long edge parallel to RhRh bonds and perpendicular to the IrIr bonds, either orientation is feasible for both metals. Although rotation of the S4 rectangle is likely a multi‐step process, a calculated barrier of 46 kcal mol−1 for a simple interconversion pathway goes through a trapezoidal, not a square, transition state. An argument is presented, based on molecular orbital (MO) calculations, that the long SS contacts (2.70 and 2.90 Å) in the rectangle are in fact two‐center, three‐electron bonds (or “half‐bonds”). Moreover, the 2− charge on the S4 rectangle is related to a Jahn–Teller distortion from a square to a rectangle. Finally, DFT is used to explore possible stable intermediates in the oxidative process giving these M4S42+ compounds: for Ir, the coupling of two Ir2S2+ molecules appears feasible, as opposed to a possible two‐electron oxidation of a neutral Rh4S4 molecule.
Time dependent vascular and myocardial responses of a second generation, small vessel, paclitaxel‐eluting stent platform
Authors: Thompson Craig A. , Huibregtse Barbara , Poff Bradley , Wilson Gregory J. 
Published: November 2008

AbstractObjectives: The purpose of this study was to evaluate the time‐dependent vascular and myocardial responses to a second‐generation, small vessel (≤2.5 mm) paclitaxel‐eluting stent (PES) platform. Background: Small caliber coronary vessels present complex challenges for percutaneous coronary intervention (PCI) and are associated with lower technical success and inferior long‐term efficacy. A next‐generation, highly deliverable PES may improve clinical outcomes in small vessels. Methods: Sixty single stents were implanted in noninjured coronary arteries in 30 domestic swine (one TAXUS® Liberté™ small vessel PES (svPES) and one Liberté small vessel bare metal stent (svBMS) in each animal). Ten animals each were allocated to 30‐, 90‐, and 180‐day follow‐up groups; final quantitative angiography and necropsy were performed. Samples of myocardium, liver, and kidney were processed and evaluated for pathology. Radiography and either histopathology or scanning electron microscopy were performed on all the explanted stented vessels. Results: There were no stent‐related deaths or downstream myocardial pathology. Both the svPES stent and its svBMS control demonstrated complete strut tissue coverage and complete endothelialization at all timepoints, and there was no evidence of macro‐ or microscopic thrombus or stent fracture. Medial smooth muscle cell content was markedly reduced in all the svPES groups compared with that in the svBMS controls. Conclusions: The small diameter paclitaxel‐eluting TAXUS Liberté stent has a safe and predictable biologic vascular response in the noninjured swine model. This device warrants further investigation targeting the currently poorly met clinical need for small vessel PCI. © 2009 Wiley‐Liss, Inc.
Paclitaxel‐eluting balloon: From bench to bed
Authors: De Labriolle Axel , Pakala Rajbabu , Bonello Laurent , Lemesle Gilles , Scheinowitz Mickey , Waksman Ron 
Published: November 2008

AbstractSince the first clinical angioplasty by Gruntzig in 1977, restenosis has been the primary drawback of percutaneous coronary intervention (PCI). In the balloon era. restenosis was correlated with elastic recoil and negative remodeling of the arterial wall. Later, introduction of stents proved to be a significant advance in reducing the elastic recoil and negative remodeling at the treatment site but stimulated proliferation, migration of smooth muscle cells, and neointimal hyperplasia, thereby generating a new type of restenosis, in‐stent restenosis. Brachytherapy and drug‐eluting stents (DES) may be considered the two breakthroughs against neointimal hyperplasia. However, concerns about stent thrombosis and incomplete elimination of in‐stent restenosis with DES in complex lesions and patients justify the pursuit of research in this field. Non‐stent based local drug delivery and particularly the use of paclitaxel‐eluting balloons could be one of these strategies. We aimed to review the concept, preclinical‐, and clinical data available with non‐stent based local drug delivery and, in particular, with paclitaxel‐eluting balloons. © 2009 Wiley‐Liss, Inc.
Orbital atherectomy for infrapopliteal disease: Device concept and outcome data for the OASIS trial
Authors: Safian Robert D. , Niazi Khusrow , Runyon John P. , Dulas Dan , Weinstock Barry , Ramaiah Venkatesh , Heuser Richard ,   For the OASIS Investigators
Published: November 2008

AbstractObjective:The purpose of this study was to assess the safety and short‐term efficacy of orbital atherectomy for chronic infrapopliteal arterial occlusive disease.Background:Infrapopliteal occlusive disease is a common cause of critical limb ischemia and claudication. There are no American College of Cardiology/American Heart Association guidelines for infrapopliteal revascularization for chronic limb ischemia.Methods:One hundred twenty four patients (201 stenoses) were enrolled in a prospective non‐randomized multicenter registry of orbital atherectomy for severe infrapopliteal disease. Data were collected as part of an investigational device exemption from the Food and Drug Administration.Results:The primary safety endpoint of major adverse events (MAE) at 30‐days (death, myocardial infarction, amputation, or repeat revascularization) was observed in four patients (3.2%). The primary efficacy endpoint (final diameter stenosis) was 17.8 ± 13.5%. The secondary endpoints of procedural success (final diameter stenosis ≤30%) and 6 month MAE (death, amputation, or target vessel revascularization) were observed in 90.1 and 10.4% of patients, respectively. Stand‐alone atherectomy was performed in 116 lesions (57.4%). At 6‐months, no patients required surgical bypass or unplanned amputation, and improvement in Rutherford ordinal scale was observed in 78.2% of patients.Conclusions:Orbital atherectomy is a unique approach to infrapopliteal disease, and provides predictable and safe lumen enlargement. Short‐term data demonstrate substantial symptomatic improvement and infrequent need for further revascularization or amputation. © 2009 Wiley‐Liss, Inc.
Catheter‐based treatment with the Amplatzer® devices in alien positions
Authors: Fischer Gunther , Smevik Bjarne , Novoa Juan Carlo Ramiro , Suáres Francisco Javier Ozores , Kramer Hans Heiner , Bjørnstad Per G. 
Published: November 2008

AbstractObjective: Case reports of patients with Amplatzer® devices used in positions they have not been designed for have repeatedly been published. Background: We pooled our results to review the array of such interventions. Methods: Retrospective study of twelve patients presented with eleven different problems: Two patients had hepatoatrial communication after Fontan's operation, two had different types of fistulae, two had surgical shunts, two had different anomalous systemic venous drainage, and two had an open arterial duct, one huge and hypertensive, the other with a very shallow ampulla. Finally, in one, a pulmonary artery was closed as a preparation for a bidirectional cavo‐pulmonary anastomosis. Results: All communications were completely closed. As only complication a lesion of the anonymous vein causing haematothorax was noted when trying to access through a Gore‐Tex® membrane after puncture. Conclusions: Such applications of Amplatzer devices in alien positions are estimated to be needed in 1 in 5–700 catheterizations. The results are good and the complications few. © 2009 Wiley‐Liss, Inc.
Contrast administration in pediatric cardiac catheterization: Dose and adverse events
Authors: Senthilnathan Selvi , Gauvreau Kimberlee , Marshall Audrey C. , Lock James E , Bergersen Lisa 
Published: November 2008

AbstractBackground: In pediatrics, contrast‐related AE such as allergic reactions, seizures, and nephropathy have been reported to occur after cardiac catheterization, but their incidence remains unknown. Objective: We sought to report adverse event (AE) rates attributed to contrast administration in a pediatric cardiac catheterization lab and identify characteristics related to higher doses. Methods: A single institution prospective cardiac catheterization AE database identified AE in children <18 years old exposed to contrast. All AE were reviewed and classified by relationship to contrast. Medical records for the 50 cases who received highest contrast doses were retrospectively reviewed for AE. Patient and procedural characteristics were compared in the top quartile of contrast dose versus remaining cases. Results: Over 3 years, 2,321 consecutive cases required median 3.9 cm3/kg [IQR: 2.0, 6.0] of contrast. Patients receiving high dose contrast (top quartile) were more likely to be <1 year (51% vs. 24%), weigh <10 kg (66% vs. 29%), have complex 2 ventricle disease (56% vs. 35%), be in a high procedure type risk group (57% vs. 26%), and undergo procedures >2 h (67% vs. 28%), all P < 0.001. Only 2 of 2,321 cases (0.09%, 95% CI 0.01–0.31%) had AE possibly related to contrast. These events were an acute neurological change and transient nephropathy. In 50 cases receiving the most contrast, no AE were attributed to contrast. Conclusion: A large volume pediatric cardiac catheterization lab administered ≥ 6 cm3/kg of contrast in a quarter of cases; however, AE related to contrast exposure were exceedingly rare. © 2008 Wiley‐Liss, Inc.
A General Approach to Aza‐Heterocycles by Means of Domino Sequences Driven by Hydroformylation
Authors: Airiau Etienne , Spangenberg Thomas , Girard Nicolas , Schoenfelder Angèle , Salvadori Jessica , Taddei Maurizio , Mann André 
Published: November 2008

AbstractThe development of hydroformylative domino reactions of easily accessible vinyl acetamides is described. Extremely regioselective hydroformylation of terminal double bounds provides a transient N‐acyliminium that can be trapped by various nucleophiles to give several aza‐heterocylic scaffolds in a diastereoselective manner.
Frequency and Outcome of Arrhythmias Complicating Admission During Pregnancy: Experience From a High‐volume and Ethnically‐diverse Obstetric Service
Authors: Li Jian‐Ming , Nguyen Carol , Joglar Jose A. , Hamdan Mohamed H. , Page Richard L 
Published: November 2008

AbstractBackgroundArrhythmias are reported during pregnancy, although hospitalization for these infrequent events is not fully characterized. The frequency and outcome of arrhythmias during pregnancy are unknown.MethodsBetween 1992 and 2000, there were 136,422 pregnancy‐related admissions to Parkland Memorial Hospital (Dallas, TX, USA). Using the discharge diagnosis data bank and the International Classification of Disease, 9th revision, Clinical Modification (ICD‐9‐CM) coding system, we identified 226 admissions (218 patients) where cardiac arrhythmias and intrauterine pregnancy were both reported.ResultsThe most common rhythm disturbances during pregnancy were sinus tachycardia (ST), sinus bradycardia (SB), or sinus arrhythmia (SA) (104 episodes/100,000 pregnancies). This was followed by paroxysmal supraventricular tachycardia (PSVT) and premature beats, with a frequency of 24/100,000 and 33/100,000, respectively. Paroxysmal supraventricular tachycardia occurred most frequently in the third trimester or peripartum. All episodes terminated spontaneously or were safely terminated with medical therapy. Advanced heart block or lethal arrhythmias were exceedingly rare during pregnancy.ConclusionMost frequently reported cardiac arrhythmias in pregnancy are benign and do not require intervention. Supraventricular tachycardia (SVT), being one of the most common complicated cardiac arrhythmias during pregnancy, can be treated effectively and safely with standard medical therapy. Ventricular arrhythmias or high‐degree atrioventricular block (AVB) during pregnancy are extremely rare. Cardiac arrest is also rare, and is often caused by a different etiology from the conventional ones for sudden cardiac death. Copyright © 2008 Wiley Periodicals, Inc.
New finite element formulation based on bubble function interpolation for the transient compressible Euler equations
Authors: Nakajima S. , Kawahara M. 
Published: November 2008

AbstractThe purpose of this paper is to present a stabilizing finite element method using a new bubble element for the unsteady fluid flow expressed by the compressible Euler equations to save efficient computational memory for computers. The formulation is based on the mixed interpolation for a transient term. The main idea of the present paper is to use the mixed interpolation for the transient term with bubble function as the weighting function and with linear function as the interpolation function. The nodal values at the bubble node can be eliminated even in the transient formulation. The stabilizing effect of the bubble function is effectively used. The formulation leads to the stabilizing effect, which is efficient to the unsteady fluid flow problems. The efficiency is verified based on the numerical studies, in which a rotating cone problem, a shock tube problem and a problem of flow around an airfoil are calculated. Copyright © 2008 John Wiley & Sons, Ltd.
Excited‐State Dynamics of Isolated DNA Bases: A Case Study of Adenine
Authors: Bisgaard Christer Z. , Satzger Helmut , Ullrich Susanne , Stolow Albert 
Published: November 2008

AbstractWe present a summary of recent advances in the understanding of the UV photophysics of the isolated DNA base adenine, emphasizing a discussion of the mechanisms behind the ultrafast relaxation following excitation to the ππ* band. Drawing on our femtosecond time‐resolved photoelectron spectroscopy experiments, we discuss differences in the ultrafast relaxation of adenine and 9‐methyladenine and consider the relative merits of the various proposed mechanisms.