bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world experience with pertuzumab and trastuzumab combined with chemotherapy in neoadjuvant treatment for patients with early-stage HER2-positive breast cancer: the NEOPERSUR study
Authors: Falcón González Alejandro , Cruz Jurado Josefina , Llabrés Valenti Elisenda , Urbano Cubero Rocío , Álamo de la Gala Maria Carmen , Martínez Guisado María Antonia , Álvarez Ambite Rocío , Rodríguez González Carlos José , Amérigo Góngora Marta , Rodríguez Pérez Lourdes , López Álvarez Pilar , Sánchez Rovira Pedro , González Flores Encarnación , Henao Carrasco Fernando , Bayo Calero Juan , Valero Arbizu María , Quílez Cutillas Alicia , Salvador Boffil Javier , Rubio Pérez Eloísa , Ruiz-Borrego Manuel 
Published: March 2024

Abstract
Purpose
HER2-targeted therapies have dramatically improved outcomes of patients with HER2-positive breast cancer (BC), as demonstrated in neoadjuvant trials. This study aims to provide real-world evidence on the use and effectiveness of combined pertuzumab, trastuzumab and chemotherapy (CT) in early-stage HER2-positive BC.

Methods
A retrospective, multicentre study was conducted on patients diagnosed with HER2-positive early BC treated with neoadjuvant pertuzumab and trastuzumab plus CT at 13 Spanish sites. The primary endpoint was pathological complete response (pCR).

Results
A total of 310 patients were included. Pertuzumab and trastuzumab were combined with anthracyclines and taxanes, carboplatin and docetaxel, and taxane-based CT in 77.1%, 16.5%, and 6.5% of patients, respectively. Overall, the pCR rate was 62.2%. The pCR was higher amongst patients with hormone receptor-negative tumours and with tumours expressing higher levels of Ki-67 (> 20%). After postoperative adjuvant treatment, 13.9% of patients relapsed. Those patients who did not achieve pCR, with tumours at advanced stages (III), and with node-positive disease were more likely to experience distant relapse. Median overall survival (OS) and distant disease-free survival (D-DFS) were not reached at the study end. The estimated mean OS and D-DFS times were 7.5 (95% CI 7.3–7.7) and 7.3 (95% CI 7.1–7.5) years, respectively (both were significantly longer amongst patients who achieved pCR). Grade 3–4 anti-HER2 related toxicities were reported in six (1.9%) patients.

Conclusion
Neoadjuvant pertuzumab and trastuzumab plus CT achieve high pCR rates in real-life patients with HER2-positive early BC, showing an acceptable safety profile. Innovative adjuvant strategies are essential in patients at high risk of distant disease recurrence.
Fluctuations in Radiation Use Efficiency Throughout the Growth Cycle in Diploid Potato Crop
Authors: Saldaña-Villota Tatiana M. , Cotes-Torres José Miguel 
Published: March 2024

AbstractThe capture of incoming solar radiation under unlimited light, water, and nutrient conditions by plant canopies and converting it into biomass has been described as radiation use efficiency (RUE). RUE has been computed as a function of biomass accumulation and intercepted photosynthetically active radiation without considering the loss of photoassimilates due to respiratory processes. This study evaluated the RUE in diploid potato crop (Solanum phureja Juz. et Buk.) across six experiments in Colombia. Total biomass was measured during the crop season from the early vegetative stage through maturity. However, this proposal involves not only the total biomass accumulated concerning the amount of photosynthetically active radiation intercepted but also took into account the losses by respiration, following Thornley respiration approach. This research demonstrates that the RUE is not a constant value as the respiration process leads to RUE values being variable in a non-linear way over time. The daily RUE simulation, conducted through an interpolation process, revealed significant variation from emergence to the end of the cycle. This indicates an error in assuming a constant RUE throughout the entire growth period, particularly in assessing its physiological impact across the entire growth and development crop cycle.
Optimization of CO2 EOR and geological sequestration in high-water cut oil reservoirs
Authors: Liu Jia , Meng Fankun , Zhao Hui , Xu Yunfeng , Wang Kai , Shi Chenyang , Chen Zifeng 
Published: March 2024

AbstractIn terms of the collaborative optimization of CO2 flooding for Enhanced Oil Recovery (EOR) and CO2 sequestration, previous studies have co-optimized both cumulative oil production and CO2 sequestration by various algorithms. However, these solutions fail to optimize the CO2 injection schemes for high-water cut oil reservoirs. This paper presents an optimization methodology for CO2 flooding and sequestration in high-water cut oil reservoirs. The production optimization was carried out by adjusting the injection and production rate. To solve the proposed objective functions, the simultaneous perturbation stochastic approximation (SPSA) algorithm is applied in this paper, and the CMG-GEM module is utilized to simulate the reservoir production performance. A typical high-water cut reservoir in the Shengli oilfield was used to verify the feasibility of the presented methodology. In this paper, the production performance and net present value (NPV) for continuous gas injection under different water cuts were analyzed. The optimal timing of transforming from water flooding to gas displacement for the high-water cut reservoir was optimized. In addition, the optimal water–gas ratios for Water-Alternating-Gas (WAG) flooding were determined. The sensitivity of NPV to gas injection price and carbon subsidy was analyzed. The results show that when the gas price is 0.178 $/m3 and the carbon subsidy is 0.0169 $/m3, the optimal timing of transforming from water flooding to gas injection should be earlier than the time when the water cut is 0.82. Through the combination of NPV, cumulative oil production rate, and CO2 sequestration volume for WAG flooding, the optimal WAG ratio should be 1:2. The presented method in this paper considers various economic indicators and can optimize CO2 flooding and sequestration in high-water cut oil reservoirs efficiently, which can provide some guidance for the design of CO2 flooding schemes in high-water cut oil reservoirs.
Rinaldo Rinaldini (1799) – ›Terrible Prestige‹ (Melville) oder ›Zauberklang‹ (Benjamin)
Authors: Schaffrick Matthias 
Published: March 2024

ZusammenfassungDer Räuberroman Rinaldo Rinaldini (1799) von Christian August Vulpius ist ein bemerkenswertes Beispiel für das unvorhersehbare Auf und Ab der Popularität. Der Roman und sein Held erfreuen sich vor allem im 19. Jahrhundert größtmöglicher Popularität. Zugleich wird der Roman von den Kritiker:innen als trivial, flach und kommerziell gescholten. Ungeachtet dieser Depopularisierung erster Ordnung (der Roman soll aus Sicht der ›Gebildeten‹ keine Beachtung finden) stößt der Roman nachweislich überall auf Resonanz. Dieser Beitrag erschließt die immanente Poetologie und die Erzählverfahren des Romans, die Popularität programmatisch verhandeln und narrativ ermöglichen, rekonstruiert seine weitläufige Rezeptionsgeschichte von der ersten Reaktion bei Goethe bis hin zur Adaption des Stoffes für eine Vorabendserie der 1960er-Jahre, und er betrachtet das schleichende Vergessen des Romans, das in seiner heutigen Nicht-Beachtung mündet (Depopularisierung zweiter Ordnung).
Climate-resilience of dams and levees in Canada: a review
Authors: Islam M. R. , Fereshtehpour M. , Najafi M. R. , Khaliq M. N. , Khan A. A. , Sushama L. , Nguyen V. T. V. , Elshorbagy A. , Roy R. , Wilson A. , Perdikaris J. , Masud M. B. , Khan M. S. 
Published: March 2024

AbstractIncreasing frequency and intensification of flooding pose significant threats to critical structures, such as dams and levees. Failure of these structures can lead to substantial economic losses and significant adverse environmental and social consequences. Improving the resilience of these structures against climate-related impacts is important to avoid future risks of failure due to the potential intensification of flooding. National-level guidance on integrating resilience-based frameworks and addressing climate risks and uncertainties in existing design flood estimation methodologies for dams and levees are lacking. To address these gaps, this study first reviews projected climate change patterns for Canada and then discusses regional vulnerabilities of dams by considering significant historical floods and their consequences. Subsequently, a review of existing design flood estimation procedures, with a focus on frequency- and probable maximum flood-based approaches, is conducted to identify areas where climate change-related aspects can be integrated. By examining the challenges associated with various stages of design flood estimation procedures, the review discusses a framework for enhancing climate resiliency of dams and levees considering four pillars of resilience. Furthermore, Canadian design flood estimation practices are compared with international practices to identify areas that require attention. The study highlights the importance of a resilience-based framework in providing design and operation guidance to ensure that dams and levees are resilient to climate impacts. Policymakers and engineers can prioritize consideration of climate-resilience in the design and operation of these structures in order to safeguard communities and infrastructure from the growing risks of future floods associated with climate change.
The role of advanced technologies and supply chain collaboration: during COVID-19 on sustainable supply chain performance
Authors: Javed Asma , Basit Abdul , Ejaz Faisal , Hameed Ayesha , Fodor Zita Júlia , Hossain Md Billal 
Published: March 2024

AbstractThe coronavirus has created significant disruptions and exposed supply chain (SC) vulnerabilities. This crisis started a discussion about SC sustainability and performance. Therefore, the implementation of advanced technologies and supply chain collaboration could mitigate this disruption with the help of government support and policies. Considering this situation, this paper examines how COVID-19 influences advanced technologies (Artificial Intelligence, the Internet of Things, Blockchain, Digital twins, and Big Data Analytics) and supply chain collaboration (SCC) with a moderating role of government support and policies (GSP) in Pakistan. The study encompasses a comprehensive assessment carried out via structural equation modeling and data collected from Pakistani companies engaged in SCM or those operating within the SC divisions of manufacturing enterprises. According to the empirical findings, it is evident that COVID-19 outbreaks have a significant influence on SSCP; However, they do not show a similar impact on advanced technologies (AI, IoT, Blockchain, DT, and BDA) and supply chain collaboration, the influence of COVID-19 on SSCP was effectively mediated through advance technologies (AI, IoT, Blockchain, DT, and BDA) and supply chain collaboration. This research contributes to the existing literature on SSCP by emphasizing the importance of the resource-based view, dynamic capability view, and institutional theories. SC and logistics managers can apply the theoretical framework proposed in this study to mitigate the impact of the COVID-19 epidemic or disruptions in logistics and SC operations, thereby improving profitability in the context of an epidemic.
Perspectives in the treatment of antibiotic-resistant bacterial infections with active photodynamic partners within the framework of the EURESTOP COST Action (CA21145)
Authors: Mori Mattia , Dumoulin Fabienne , Faustino M. Amparo F. , Plaetzer Kristjan 
Published: March 2024

AbstractThe European Network for diagnosis and treatment of antibiotic-resistant bacterial infections—EURESTOP COST Action CA21145 focuses on tackling the burden of antimicrobial resistance (AMR) and has gathered many members working on photodynamic approaches. This European consortium is presented here in the One Health context, to highlight the potential of antimicrobial photodynamic therapy (aPDT) in the fight against AMR.
Patterns of residential differentiation and labor control at Baking Pot and Lower Dover in the Belize River Valley
Authors: Walden John P. , Hoggarth Julie A. , Ebert Claire E. , Shaw-Müller Kyle , Ran Weiyu , Qiu Yijia , Ellis Olivia P. , Meyer Brett , Biggie Michael , Watkins Tia B. , Guerra Rafael A. , Awe Jaime J. 
Published: March 2024

AbstractThe Classic Maya polities of Baking Pot and Lower Dover developed along two dramatically different trajectories. At Baking Pot, the capital and associated apical elite regime grew concomitantly with surrounding populations over a thousand-year period. The smaller polity of Lower Dover, in contrast, formed when a Late Classic political center was established by an emergent apical elite regime amidst several long-established intermediate elite-headed districts. The different trajectories through which these polities formed should have clear implications for residential size variability. We employ the Gini coefficient to measure variability in household volume to compare patterns of residential size differentiation between the two polities. The Gini coefficients, while similar, suggest greater differentiation in residential size at Baking Pot than at Lower Dover, likely related to the centralized control of labor by the ruling elite at Baking Pot. While the Gini coefficient is synonymous with measuring wealth inequalities, we suggest that in the Classic period Belize River Valley, residential size was more reflective of labor control.
Quantitative analyses of wealth inequality at Classic period El Pilar: The Gini index and labor investment
Authors: Horn Sherman , Tran Justin , Ford Anabel 
Published: March 2024

AbstractSurvey teams at the El Pilar Archaeological Reserve for Maya Flora and Fauna have mapped 70 percent of its 20 km2 area and revealed the extent of settlement around the city center. Large-scale civic architecture, and the distribution of smaller ceremonial groups and minor centers, reflect the wealth and power of Maya rulers presiding over the largest Classic period city in the upper Belize River area. Previous analyses suggest disparities in wealth at El Pilar were more nuanced than the elite/commoner dichotomy commonly invoked for Classic Maya society. This article works to understand wealth inequality at ancient El Pilar by computing Gini coefficients from areal and volumetric calculations of primary residential units—the class of settlement remains most likely to represent ancient households. Presentation of Gini coefficients and their potential interpretations follows a discussion of settlement classification and residential group labor investment. We conclude by contextualizing these results within prior settlement pattern analyses to explore how disparities in wealth may have been distributed across the physical and social landscape.
The Projected Response of the Water Cycle to Global Warming Over Drylands in East Asia
Authors: Ren Yu , Yu Haipeng , Huang Jianping , Peng Ming , Zhou Jie 
Published: March 2024

AbstractClimate change exacerbates the threat of water scarcity over the drylands in East Asia (DEA), the world's most densely populated arid region. The water cycle continuously supplies water to support all life. Previous studies have focused on the change in individual hydrological components over DEA; however, how the projected water cycle changes under climate warming remains unclear. We demonstrate the projected response of the water cycle to global warming in different seasons utilizing the Coupled Model Intercomparison Project Phase 6. Winter in the DEA presents an intensification of the water cycle, reflected in coherent increases in evapotranspiration (E), precipitation (P), runoff, and surface soil moisture. In contrast, summer will experience a weakened water cycle in the northwestern DEA, while the southeastern part exhibits the opposite trend. From the surface and atmospheric water balance perspective, we further attribute the changes in E and P to gain a more comprehensive understanding. The increasing E is attributed to the combined effects of P and the vapor pressure deficit during summer, whereas it is dominated by P in winter. The increased P in summer is primarily attributed to the horizontal dynamic and vertical thermodynamic components associated with the strengthening and westward expansion of East Asia summer monsoon in the future. During winter, the increased P is mainly due to the vertical dynamic and horizontal thermodynamic components associated with the enhancement of vertical ascending motion and increased moisture.
The Precipitation Response to Warming and CO2 Increase: A Comparison of a Global Storm Resolving Model and CMIP6 Models
Authors: Guendelman Ilai , Merlis Timothy M. , Cheng Kai‐Yuan , Harris Lucas M. , Bretherton Christopher S. , Bolot Maximilien , Zhou Linjiong , Kaltenbaugh Alex , Clark Spencer K. , Fueglistaler Stephan 
Published: March 2024

AbstractGlobal storm‐resolving models (GSRMs) that can explicitly resolve some of deep convection are now being integrated for climate timescales. GSRMs are able to simulate more realistic precipitation distributions relative to traditional Coupled Model Intercomparison Project 6 (CMIP6) models. In this study, we present results from two‐year‐long integrations of a GSRM developed at Geophysical Fluid Dynamics Laboratory, eXperimental System for High‐resolution prediction on Earth‐to‐Local Domains (X‐SHiELD), for the response of precipitation to sea surface temperature warming and an isolated increase in CO2 and compare it to CMIP6 models. At leading order, X‐SHiELD's response is within the range of the CMIP6 models. However, a close examination of the precipitation distribution response reveals that X‐SHiELD has a different response at lower percentiles and the response of the extreme events are at the lower end of the range of CMIP6 models. A regional decomposition reveals that the difference is most pronounced for midlatitude land, where X‐SHiELD shows a lower increase at intermediate percentiles and drying at lower percentiles.
Phase and Amplitude Scintillations Associated With Polar Cap Patches: Statistical and Event Analyses
Authors: Cardenas‐O’Toole Alanah M. , Zou Shasha , Ren Jiaen , Wang Zihan , Jayachandran P. T. 
Published: March 2024

AbstractIonospheric scintillation causes errors in radio signals. One potential source in the polar region is polar cap patches. Using a polar cap patch database from Ren et al. (2018), https://doi.org/10.1029/2018ja025621 and data provided by a scintillation receiver at Resolute Bay, we evaluated the polar cap patch impact on ionospheric scintillation. In a statistical analysis, we found that 92% of the maximum patch scintillation was under 0.3 for both phase (in the unit of radian) and amplitude scintillations. Of the remaining 8%, less than 1% could be classified as severe phase scintillation (>0.5 radians), while none could be classified as severe amplitude scintillation. Magnetic Local Time (MLT) dependence of the patch phase scintillation shows higher scintillation values near noon MLTs. Patches are classified into cold, hot‐Te and hot‐Te‐Ti types based on their plasma temperatures. The dependence of scintillation on the patch density prominence showed a positive correlation between phase scintillation and cold patches near noon MLT and hot‐Te patches everywhere except midnight MLT. In the event analysis, two events were studied. The first event with large phase scintillation was located in the polar cap with weak polar rain precipitation and large, uniform, antisunward convection flows. The second event with large amplitude scintillation was located in a region with active soft particle precipitation and velocity shear, classical ionospheric signatures of plasma sheet boundary layer. The statistical and event analysis improve understanding of the location and characteristics of patch‐related scintillations.
Mapping Ice Buried by the 1875 and 1961 Tephra of Askja Volcano, Northern Iceland Using Ground‐Penetrating Radar: Implications for Askja Caldera as a Geophysical Testbed for In Situ Resource Utilization
Authors: Shoemaker E. S. , Baker D. M. H. , Richardson J. A. , Carter L. M. , Scheidt S. P. , Whelley P. L. , Young K. E. 
Published: March 2024

AbstractEruptions of the Askja Volcano in Northern Iceland in 1875 and 1961 blanketed the caldera with rhyolitic and basaltic tephra deposits, respectively, which preserved layers of seasonal snowpack as massive ice. Askja serves as an operational and geophysical analog to test ground‐penetrating radar field and analysis techniques for in situ resource utilization objectives relevant to the martian and lunar environments. We conducted ground‐penetrating radar surveys at center frequencies of 200, 400, and 900 MHz to map the thickness and extent of tephra deposits and underlying massive ice at three caldera sites. We identified up to 1 m of tephra preserving up to 4.4 m of massive ice. We measured the real dielectric permittivity of the overlying tephra and the total attenuation at each frequency of the tephra and ice. A key objective of our investigation was to determine if attenuation (or loss) could be used as an additional diagnostic signature of massive ice preserved at depth when compared to ice‐free stratigraphy. Loss rates of the ice‐rich subsurface decrease with increasing ice thickness relative to the overburden, which may constitute a possible signature. Attenuation also increased with increasing frequency. The tephra, ice, and other volcanic deposits at each of our three caldera sites and the ice‐free, pumice‐mantled 1961 Vikrahraun lava flow exhibited consistently low loss rates at all frequencies. This result highlights the ambiguity associated with identifying the unique signature of ice within low‐loss stratigraphies, a possible challenge for its identification in the martian or lunar subsurface using radar.
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry
Authors: Brioli Annamaria , Lomaia Elza , Fabisch Christian , Sacha Tomasz , Klamova Hana , Morozova Elena , Golos Aleksandra , Ernst Philipp , Olsson-Stromberg Ulla , Zackova Daniela , Nicolini Franck E. , Bao Han , Castagnetti Fausto , Patkowska Elzbieta , Mayer Jiri , Hirschbühl Klaus , Podgornik Helena , Paczkowska Edyta , Parry Anne , Ernst Thomas , Voskanyan Astghik , Szczepanek Elzbieta , Saussele Susanne , Franke Georg-Nikolaus , Kiani Alexander , Faber Edgar , Krause Stefan , Casado Luis Felipe , Lewandowski Krzysztof , Eder Matthias , Anhut Peter , Gil Justyna , Südhoff Thomas , Hebart Holger , Heibl Sonja , Pfirrmann Markus , Hochhaus Andreas , Lauseker Michael 
Published: March 2024

AbstractBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected heterogeneity of the entity, lacking a clear treatment standard. Outcomes remain dismal, with a median overall survival of 23.8 months (median follow up 27.8 months). Allogeneic stem cell transplantation (alloSCT) increases the rate of deep molecular responses. De novo BP and BP evolving from a previous CML do show slightly different features, suggesting a different biology between the two entities. Data show that outside clinical trials and in a real-world setting treatment of blast phase is individualized according to disease- and patient-related characteristics, with the aim of blast clearance prior to allogeneic stem cell transplantation. AlloSCT should be offered to all patients eligible for this procedure.