bluuebunny/crossref_metadata_2025_split huggingface dataset:
Draft genome of the
Klebsiella pneumoniae
24Kpn33 and complete sequence of its pCOL-1, a plasmid related to the
bla
KPC-2
acquisition in
Pseudomonas aeruginosa
Authors: Abril Deisy , Lesmes-Leon Duway Nicolas , Marquez-Ortiz Ricaurte Alejandro , Leal Aura Lucía , Tovar-Acero Catalina , Corredor Rozo Zayda Lorena , Vanegas Gómez Natasha , Escobar-Perez Javier 
Published: March 2024

ABSTRACT

We report the draft genome of a clinical multi-resistant
Klebsiella pneumoniae
(24Kpn33) isolate, whose genome (5.7 Mbp) harbored 17 antibiotic resistance genes, including
bla
KPC-2
. Notably, this gene was mobilized within the IncP-6 pCOL-1 plasmid, the first genetic platform related to the acquisition and dissemination of the
bla
KPC-2
in
Pseudomonas aeruginosa
.
Protocol for the diagnostic performance of C reactive protein, procalcitonin and interleukin-6 for serious bacterial infections among children ≤36 months old presenting with fever without source: a systematic review and meta-analysis
Authors: Sutiman Natalia , Yao Sarah Hui Wen , Goh Sharon Si Min , Sultana Rehena , Chong Shu-Ling 
Published: March 2024

IntroductionThe management of fever without source in children ≤36 months old remains a diagnostic challenge as the underlying aetiologies can vary from self-limiting viral infections to serious bacterial infections (SBIs). Biomarkers such as C reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) have varying thresholds in the prediction of SBIs due to differences in SBI definitions, SBI prevalence, patient characteristics and timing of presentation. This protocol describes a systematic review and meta-analysis that aims to determine the thresholds at which CRP, PCT and IL-6 can perform optimally in distinguishing the presence of SBIs in children ≤36 months old, as well as to determine their performances in early detection of bacterial infections within 48 hours of fever onset.Methods and analysisWe will systematically search electronic databases including MEDLINE, Cochrane Central Register of Controlled Trials, Cochrane CENTRAL, EMBASE, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and Science Citation Index from 1 July 2023 to 31 July 2023. We will include studies that report the diagnostic accuracy of CRP, PCT and IL-6 in detecting SBIs in children aged ≤36 months presenting with fever without apparent source. Randomised controlled trials (RCTs) and non-randomised studies including non-RCTs and controlled before-and-after studies will be included. A meta-analysis will be performed and diagnostic performances of these biomarkers will be reported.Ethics and disseminationThe results of this study will provide guidance on clinical decision-making in young children presenting with fever without source. Ethics approval will not be required for this study. The authors aim to publish the findings in a peer-reviewed journal as well as present at international conferences.PROSPERO registration numberCRD42023439093.
Prevalence and correlates of workplace violence: descriptive results from the National Transgender Discrimination Survey
Authors: Enogieru Idia , Blewitt-Golsch Ashley L. , Hart Lauren J. , LeGrand Sara , Whetten Kathryn , Ostbye Truls , Johnson Candice Y. 
Published: March 2024

ObjectiveTo describe the lifetime prevalence of workplace harassment, physical violence and sexual assault against transgender and non-binary workers targeted due to their gender identity and to identify correlates of this workplace violence.MethodsThis descriptive cross-sectional study used data from 4597 transgender or non-binary respondents from the 2008–2009 National Transgender Discrimination Survey. Respondents reported if they had ever experienced harassment, physical violence or sexual assault at work specifically because of their gender identity. We estimated the prevalence of each type of violence stratified by gender identity, race/ethnicity, age, educational attainment, history of working in the street economy (eg, sex industry, drug sales) and if people at work knew their gender identity.ResultsWorkplace violence was prevalent, with 50% of transgender and non-binary workers having ever experienced harassment, 7% physical violence and 6% sexual assault at work because of their gender identity. Harassment was common among all of these workers, but physical violence and sexual assault were more than twice as common among transfeminine and non-binary workers assigned male at birth, workers of colour, workers with low educational attainment and those who had ever worked in the street economy.ConclusionsTransgender and non-binary workers commonly face violence at work because of their gender identity. Workplace violence prevention programmes should incorporate ways to prevent gender identity-based violence and facilitate channels for workers to report the occurrence of discrimination and violence.
Distinct trajectories of lung function from childhood to mid-adulthood
Authors: Zhang Xian , Gray Andrew R , Hancox Robert J 
Published: March 2024

RationaleLife course trajectories of lung function development and decline influence the risk for lung disease but are poorly documented.ObjectiveTo document lung function trajectories from childhood to mid-adult life.MethodsWe modelled forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC at ages 9, 11, 13, 15, 18, 21, 26, 32, 38 and 45 years from a population-based cohort using latent profile analysis to identify distinct subgroups of participants with similar lung function trajectories. Regression analyses were used to assess associations between the trajectories, early life factors and postbronchodilator airflow obstruction at age 45.ResultsAmong 865 participants with ≥6 measures of lung function, we identified 10 distinct FEV1trajectories. Most were approximately parallel except for a childhood airway hyper-responsiveness-related persistently low trajectory (3% of study population); two accelerated-decline trajectories, one of which (8%) was associated with smoking and higher adult body mass index (BMI) and a catch-up trajectory (8%). Findings for FEV1/FVC trajectories were similar. Nine trajectories were identified for FVC: most were also approximately parallel except for a higher BMI-related accelerated-decline trajectory. The three FEV1trajectories leading to the lowest FEV1values comprised 19% of the cohort but contributed 55% of airflow obstruction at age 45.ConclusionsLung function trajectories to mid-adult life are largely established before adolescence, with a few exceptions: a childhood airway hyper-responsiveness-related persistently low trajectory, which starts low and gets worse with age, and accelerated adult decline trajectories associated with smoking and obesity. Adverse trajectories are associated with a high risk of airflow obstruction in mid-adult life.
Electric scooter-related orthopedic injuries: the experience of an Italian orthopedic center and literature review
Authors: Luceri Francesco , Monteleone Valerio , Randelli Pietro Simone 
Published: March 2024

BackgroundWith the increasing prevalence of electric scooters, a concomitant increase in the number of specific injuries, emergency department (ED) admissions and hospital admissions have been reported.ObjectivesAnalyze patient flow changes in the ED with a focus on e-scooter-related injuries through a case series and a comparison with the contemporary literature.Data sourcesA systematic literature review was performed on Medline/PubMed and Embase using terms related to the topic.Data collected from two-wheeled vehicle trauma patients at our Italian ED from May 1 to October 31, 2021, were analyzed for the case series.Study eligibility criteriaStudies were included if they evaluated populations with an e-scooter-related injury referred to the ED with precise localization and nature of the injury reported.Participants and interventionsData collected from the literature studies and from our case series included overall ED patient numbers, patient demographics, injury mechanism, location of the injury, discharge diagnosis, and performance of surgery.Study appraisal and synthesis methodsAll studies were checked in order to establish the coherence with the purposes of this review. Data from the contemporary literature and from this case series were compared.ResultsDuring a 6-month period, 280 patients had e-scooter injuries, resulting in 292 traumas, including 123 fractures, primarily in the elbow. Surgical intervention was necessary for 28 patients. The review included nine papers, highlighting that injuries to the upper and lower extremities and head were frequent in e-scooter-related incidents. The upper extremities were the most common fracture location.LimitationsThe study is a retrospective, single-center study without a comparison group, focusing exclusively on orthopedic injuries.Conclusions or implications of key findingsThe prevalence of electric scooters, which offer an affordable and eco-friendly mode of transport, is steadily increasing. It is important to focus on injury risk mitigation through effective public health policies, thereby lowering costs to society.
An Italian InterLaboratory comparison on personal dose equivalent for dosimetry services: promoting measurements reliability and addressing new digital challenges
Authors: Iafrati Anna Cristina , Cappadozzi Gianluca , Silvestri Claudia , Pinto Massimo 
Published: March 2024

AbstractAn InterLaboratory Comparison on personal dose equivalent, Hp(10), a fundamental part of radiation protection dosimetry measurements, was organized aiming at evaluating the measurement capability of dosimetry services across Italy, in order to ensure the reliability of the measurements. For the intercomparison, each participant sent their own passive dosimeters, which were exposed to gamma radiation beams emitted from a S-Cs source and to medium-energy filtered X-ray beams of the wide spectrum series, at the ISO 4037-1 W-80 quality. Results were evaluated by applying the statistical estimator R, which compares the communicated dose equivalent values and the reference, assigned values, and then evaluated using trumpet curves. Data were acquired using web forms, collected in internal databases, and processed using statistical software, aiming at the automation of analysis and preparation of technical reporting. Results indicate a good level of maturity in the measurement capabilities in radiation protection dosimetry in the italian dosimetry services who participated. The intercomparison was an opportunity for mutual improvement between the participating dosimetric services and the organizing institute: the former were able to compare themselves and have their capabilities assessed from an external provider; while, the latter had the chance to improve their management and organization skills for a large, multi-lateral intercomparison.
Long‐Term Survival After Single‐Ventricle Palliation: A Swedish Nationwide Cohort Study
Authors: Dalén Magnus , Odermarsky Michal , Liuba Petru , Johansson Ramgren Jens , Synnergren Mats , Sunnegårdh Jan 
Published: March 2024

Background
Long‐term survival after single‐ventricle palliation and the effect of dominant ventricle morphology in large, unselected series of patients are scarcely reported.

Methods and Results
This nationwide cohort study included all children undergoing operation with single‐ventricle palliation during their first year of life in Sweden between January 1994 and December 2019. Data were obtained from institutional records and assessment of underlying cardiac anomaly and dominant ventricular morphology was based on complete review of medical records, surgical reports, and echocardiographic examinations. Data on vital status and date of death were retrieved from the Swedish Cause of Death Register, allowing for complete data on survival. Among 766 included patients, 333 patients (43.5%) were classified as having left or biventricular dominance, and 432 patients (56.4%) as having right ventricular (RV) dominance (of whom 231 patients had hypoplastic left heart syndrome). Follow‐up was 98.7% complete (10 patients emigrated). Mean follow‐up was 11.3 years (maximum, 26.7 years). Long‐term survival was significantly higher in patients with left ventricular compared with RV dominance (10‐year survival: 91.0% [95% CI, 87.3%–93.6%] versus 71.1% [95% CI, 66.4%–75.2%]). RV dominance had a significant impact on outcomes after first‐stage palliation but was also associated with impaired survival after completed total cavopulmonary connection. In total, 34 (4.4%) patients underwent heart transplantation. Of these 34 patients, 25 (73.5%) had predominant RV morphology.

Conclusions
This study provides clinically relevant knowledge about the long‐term prognosis in patients with different underlying cardiac anomalies undergoing single‐ventricle palliation. RV dominance had a significant impact on outcomes after initial surgical treatment but was also associated with impaired survival after completed Fontan circulation.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03356574.
The Healthcare Cost of Air Pollution: Evidence from the World's Largest Payment Network
Authors: Barwick Panle Jia , Li Shanjun , Rao Deyu , Zahur Nahim Bin 
Published: March 2024

Abstract
This paper exploits the universe of credit- and debit-card transactions in China during 2013-2015 and provides the first nationwide analysis of the healthcare cost of PM2.5 for a developing country. We leverage spatial spillovers of PM2.5 from long-range transport to generate exogenous variation in local pollution and employ a flexible distributed lag model to capture semiparametrically the dynamic response of pollution exposure. We find significant impacts of PM2.5 on healthcare spending in both the short and medium terms. A 10 μg/m3 decrease in PM2.5 would reduce annual healthcare spending by over $9.2 billion, about 1.5% of China's annual healthcare expenditure.
Optimal Ownership and Firm Performance: An Analysis of China's FDI Liberalization
Authors: Eppinger Peter , Ma Hong 
Published: March 2024

Abstract
Seminal theories of the firm posit that firm ownership is allocated to minimize contractual inefficiencies. Yet, it remains unclear how much the optimal ownership choice affects firm performance in practice. This paper provides a first quantification of the gains from optimal ownership within multinational firms, by exploiting a major liberalization of China's policy restrictions on foreign ownership. The liberalization allowed previously restricted firms to become fully foreign owned. We find that these reoptimized ownership choices raise firm output by 40% and productivity by 7.5% on average. An extended property-rights theory of the multinational firm rationalizes these effects and their heterogeneity.
The Unobserved Returns to Entrepreneurship
Authors: Sarada  
Published: March 2024

Abstract
This paper presents an alternative perspective to a longstanding empirical puzzle: that most entrepreneurs persevere despite persistently low earnings. Because entrepreneurial earnings are notoriously difficult to measure, I approach the question from an expenditure angle. I look at how switching into self-employment corresponds to changes in reported earnings versus expenditure. Using 45 years of longitudinal data, I find that individuals report earning 27.7% less in self-employment, while spending 3.8% more. This household expenditure premium accrues with entrepreneurial experience and is not offset by lower savings or longer work hours. The results hold in highly educated and incorporated business owner subsamples.
Integrating Farmers’ Perspectives into Earth System Model Development: Interviews with End Users in the Willamette Valley, Oregon, to Guide Actionable Science
Authors: Emard Kelsey , Cameron Olivia , Wieder William R. , Lombardozzi Danica L. , Morss Rebecca , Sobhani Negin 
Published: March 2024

Abstract
This paper analyzes findings from semistructured interviews and focus groups with 31 farmers in the Willamette Valley in which farmers were asked about their needs for climate data and about the usability of a range of outputs from the Community Earth System Model, version 2 (CESM2), for their soil management practices. Findings indicate that climate and soils data generated from CESM and other Earth system models (ESMs), despite their coarse spatial scale resolutions, can inform farmers’ long-term decisions, but that the data would be more usable if the outputs were provided in a format that allowed farmers to choose the variables and thresholds relevant to their particular needs and if ESMs incorporated farmer practices including residue removal, cover cropping, and tillage levels into the model operations so that farmers could better understand the impacts of their decisions. Findings also suggest that although there is a significant gap in the spatial resolution at which these global ESMs generate data and the spatial resolution needed by farmers to make most decisions, farmers are adept at making scalar adjustments to apply coarse-resolution data to the specifics of their own farm’s microclimate. Thus, our findings suggest that, to support agricultural decision-making, development priorities for ESMs should include developing better representations of agricultural management practices within the models and creating interactive data dashboards or platforms.
Errorless Training Benefits Motor Learning and Kinematic Outcomes in Children With Autism Spectrum Disorders
Authors: Arsham Saeed , Razeghi Rahil , Movahedi Ahmadreza 
Published: March 2024

Most children with Autism Spectrum Disorder (ASD) have some form of motor deficits. Additionally, based on executive dysfunction, working memory is often atypical in these children. Errorless learning reduces demands on working memory. In this study, we investigated the effectiveness of errorless training on these children’s ability to learn golf putting. Participants ( N = 20), aged 9–13 years ( M = 10.15, SD = 1.4), were randomly assigned to either: (a) an errorless (ER) training group ( n = 10) or (b) an explicit instruction (EI) group ( n = 10). The ER group practiced putting from different distances without any instruction, while the EI group practiced putting at a particular distance with instruction. We measured motor performance (e.g., putting accuracy) and kinematic variables (e.g., putter face angle). One-way analyses of variance showed that motor performance significantly improved in both groups, but that the ER group showed significantly better accuracy retention ( p < .028) and transfer learning ( p < .047) than the instructional group. Kinematic variables were also significantly different between the two groups on the transfer test. These findings supported the benefits of errorless training compared to explicit instruction to teach motor skills to children with ASD.
Supine versus prone percutaneous nephrolithotomy in management of patient with complex renal stone diseases
Authors: Maiti Krishnendu , Khare Kani Dayal , Pal Dilip Kumar 
Published: March 2024

Objectives: Compare the surgical outcomes, safety, stone free rate, hospital stay, and complication of prone and supine PCNL in case of complex renal stone. Materials and methods: This is an observational study conducted in our institute, it consist of 120 patients over the period of 2 years from July 2021 to June 2023, all the patients were divided into two groups: 60 patients underwent modified supine percutaneous nephrolithotomy (PCNL) and remaining 60 patients underwent standard prone PCNL. The measured data included operative time, number of punctures, blood loss, stone-free rate, length of hospital stays, and rate of complications. Results: The two groups were comparable in mean age, male to female ratio, number of punctures, number of tract, size of tract, residual calculi in follow up period, blood transfusion, re-do surgery, chest complication, hospital stay, and postoperative fever and pain. The mean operating time was 1.59 h in supine PCNL and 2.49 h in prone PCNL. The p value was significant ( p = 0.001). Conclusions: By this study we observed that the supine PCNL is associated with statistically significant reduced operating time as compared to conventional prone PCNL with advantages of not putting the patient in prone position. The postoperative complications such as pain and fever were not significant when compared in both groups. We conclude our study and found that, the supine PCNL is an equally effective in treating complex renal stone as compared to prone PCNL.
Prevalence and Characteristics of Pathological Fractures in Patients Referred to Specialist Palliative Care: A Retrospective Study From India
Authors: Kuriakose Jyothsna , Surendran Sumith , Deodhar Jayita K. , P Prasun , Sonawane Rutula N. , Jayaseelan Prarthna 
Published: March 2024

Background: Prevalence of pathological fractures in palliative care is less studied. This study aimed to determine the annual prevalence of pathological fractures and describe the characteristics and treatments in patients with pathological fractures referred to a specialist palliative care clinic in a tertiary care cancer center in India. Methods: Data of adult cancer patients newly referred to the specialist palliative care clinic over 1 year with a clinico-radiological diagnosis of pathological fracture was included. Key outcomes of interest were annual prevalence, clinical characteristics, symptoms and treatments offered. Results: 75 out of 5800 (1.29%) patients newly referred to the clinic over 1 year had pathological fractures. Lung cancer was the most common primary diagnosis (n = 23).Dorsal spine (n = 25) was the most common site of fracture. Pain was the predominant symptom. Mean pain score was 7.04(SD = 1.75) and 42 patients (56%) required strong opioids for analgesia. Only 11 (16%) patients underwent surgical fixation. Median duration from diagnosis of cancer to occurrence of fracture was found to be 329 days. Treatment goals changed to best supportive care in 33 patients (44%) post fracture. Patients with bone and soft tissue neoplasms and those who received only chemotherapy previously had a higher risk of occurrence of fractures. Conclusion: Annual prevalence of pathological fractures in patients referred to the specialist palliative care clinic was 1.29%. It was associated with significant symptom burden and affected oncological treatments. Close monitoring of patients with bone metastases is crucial and proactive implementation of prophylactic measures to prevent such skeletal related events is warranted.