bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant Effects of Aerobic Exercise After Spinal Cord injury
Authors: Linnman Clas , Mercier Hannah , Picard Glen , Solinsky Ryan , Taylor Andrew 
Published: February 2024

Abstract
Study Design: Secondary outcome measures analysis of a randomized, controlled study.
Objectives: To assess the effects of hybrid-functional electrical stimulation (FES) rowing, arms only (AO) rowing and waitlist (WL) controls on pain, pain interference, and depression in individuals with spinal cord injury (SCI).
Setting: Outpatient rehabilitation networks
Methods: 44 participants were randomly assigned to FES (n = 19), AO (n= 12) or WL (n=13). The FES group completed 6 months of rowing scheduled 3 times per week. Individuals in the AO and WL groups were allowed to cross over to FES rowing after 6 months and were included in subsequent analyses of the effects of FES rowing. Rowing distance and intensity was logged, and maximal oxygen consumption (VO2max) measures were obtained before and after the intervention. Changes in the Patient-Reported Outcomes Measurement Information System (PROMIS-56) derived pain interference, pain, and depression scores were analyzed.
Results: FES-rowing led to modest improvements in depression, AO led to modest improvements in pain intensity, and WL did not improve pain nor depression. After incorporating individuals who crossed over to FES rowing, we observed modest but significant improvement in depression scores but not in pain. Among the participants who benefited from the FES intervention, the reduction in depression was correlated to the average weekly rowing distance (r2=0.79 p=0.0001).
Conclusions: 6 months of FES rowing spent in a supportive environment can help persons with spinal cord injuries alleviate moderate depression in a dose-dependent manner.
Filter cable design with defected conductor transmission structures
Authors: Yunan Han , Jiang Cuilian , Xiong Shuangqing , Liu Zhaohan 
Published: February 2024

Abstract

This article introduces a filter cable design featuring an insulated cylinder that has been coated using a defected conductor transmission structure (DCTS). This unique feature enables the cable to possess distributed filter advantages throughout its length. The DCTS, featuring a well-designed etched pattern, serves as a boundary condition for transmitting specific frequency electromagnetic waves and effectively performs the same filtering function as a lumped filter circuit. To validate this concept, a lowpass filter cable is proposed, which incorporates six-slot-ring defected structures. The cable utilizes polytetrafluoroethylene (PTFE) as the inner dielectric, encased within a flexible printed circuit board (FPCB)-manufactured DCTS. With precise dimensions of a 2.4 mm diameter and a 340 mm length, the proposed filter cable demonstrates performance, indicated by a minimal insertion loss of under 0.38 dB below 6 GHz in the passband, and a rejection surpassing 43 dB at 7.7-25 GHz in the stopband. By comparison, traditional coaxial cables lack these filtering capabilities, making the filter cable with DCTS a viable choice for addressing electromagnetic compatibility (EMC) concerns.
Will olive groves have a future under climate change conditions in the North Aegean sub-region, a Mediterranean agricultural environment of Turkey?
Authors: Türkeş Murat , Sahin Sinan 
Published: February 2024

Abstract

The study is aim at investigating future changes in sustainability of olive farming by means of climate change, and changes in suitableness and phenology of olive tree cultivation in the study area characterised mainly with Mediterranean climate. According to projected changes based on RCP8.5 scenario, air temperatures will increase significantly, and in the 2073–2098 period, projected warming reaches an average of 5–6°C with a most negative condition on olives in terms of warming during 2073–2098 period. Annual precipitation projections based on RCP8.5 scenario indicated that present suitable areas of olive groves will decrease in the period of 2049–2073, and almost the entire study area will be in the category of medium suitable in the period of 2073–2098. With respect to projected Emberger Bioclimate classification, for RCP 8.5 scenario, in the period of 2049–2073, there will be a significant increase in dry-sub humid areas. This increase will cover up the coastal areas in the period of 2074–2098, and even all the study area was determined as the dry-sub humid and semi-arid Mediterranean bioclimatic layer except for some coastal areas. An increase of about 6°C is expected in maximum values of maximum air temperatures during the swelling periods, especially in the periods after 2050 for RCP8.5 scenario. This increase in extreme maximum temperatures may cause olive trees to bloom earlier and prolong growth period. By regarding the high vernalization requirement of main olive variety in the study area, a 6°C temperature increase may significantly decrease olive yields and will force farmers to transition to new varieties with relatively low vernalization requirements. According to both RCP scenarios, there is a possibility of extension of suitable areas for olive cultivation towards low to mid-altitude plateaus and middle-altitude slopes of mountainous areas and high plateaus particularly facing suitable aspects to lower negative effects of projected warming and dryness.
Osteoclast indices in osteogenesis imperfecta: systematic review and meta-analysis
Authors: Aksornthong Sirion , Patel Priyesh , Komarova Svetlana V 
Published: February 2024

Abstract

Background: Osteogenesis imperfecta (OI) is a rare bone fragility disorder caused by mutations in genes that encode collagen type I or affect its processing. Alterations in bone resorbing osteoclasts were suggested to contribute to OI pathophysiology. We aimed to systematically identify studies reporting measures of osteoclast formation and function in patients and mouse models of OI, to quantify OI-induced changes.
Results: The systematic search of Medline, OVID and Web of Science identified 798 unique studies. After screening, we included for meta-analysis 23 studies reporting osteoclast parameters in 310 OI patients of 9 different types and 16 studies reporting osteoclast parameters in 406 animals of 11 different OI mouse models. The standardized mean difference was used as the effect size, random effects meta-analysis was performed using R-studio. In OI patients, collagen degradation markers were significantly higher in patients with OI compared to age-matched control with the effect size of 1.23 [Confidence interval (CI): 0.36, 2.10]. Collagen degradation markers were the most elevated in the 3 to 7-year-old age group, and in patients with more severe forms of OI. Bone histomorphometry demonstrated the trends for higher osteoclast numbers, 1.16 [CI: -0.22, 2.55], and osteoclast surface, 0.43 [CI: -0.63; 1.49], and significantly higher eroded surface, 3.24 [CI: 0.51, 5.96] compared to the aged-match control. In OI mice, meta-analysis demonstrated significant increases in collagen degradation markers, 1.59 [CI: 1.07, 2.11]; in osteoclast numbers, 0.94 [CI: 0.50, 1.39], osteoclast surface, 0.73 [CI:0.22, 1.23], and eroded surface 1.31[CI: 0.54, 2.08]. The largest differences were in OI mice with the mutations in Col1a1 and Col1a2 genes. There were no differences between males and females in clinical or animal studies.
Conclusions: Quantitative estimates of changes in osteoclast indices and their variance for patients with OI are important for planning future studies. We confirmed that similar changes are observed in mice with OI, supporting their translational utility.
A Bayesian causal inference model to evaluate shoulder pathology effect on glenoid bone mineral density
Authors: Terrier Alexandre , Eghbali Pezhman , Satir Osman , Becce Fabio , Goetti Patrick , Buechler Philippe , Pioletti Dominique 
Published: February 2024

Abstract
The effect of shoulder pathologies on glenoid bone mineral density (BMD) remains unclear and can be critical in surgical treatments. It is thus useful to predict this effect and understand how it is influenced by sex, age, and body mass index (BMI), in various glenoid locations. To address this question, we developed a causal model and used do-calculus to identify the minimal adjustment set of covariate variables and developed a varying-intercept varying-slope Bayesian model. We considered two common shoulder pathologies, primary osteoarthritis (OA) and cuff tear arthropathy (CTA), and compared them with normal shoulders (CTRL). Glenoid BMD was automatically measured on computed tomography scans of 93 OA, 53 CTA, and 133 CTRL subjects.
OA and CTA subjects had higher BMD than CTRL in subchondral trabecular bone. This difference was affected by sex, increased with age, and was stable with BMI. BMD was higher in OA than CTA, especially on the posterior side.
This causal model could be used for surgery planning, outcome prediction, and understanding of the associated pathophysiology.
Foreign faces facilitating specific emotional connotation acquisition for L2 words
Authors: Gu Beixian , Sun Xiaobing , Beltrán David , de Vega Manuel 
Published: February 2024

Abstract
This study explored the effects of Caucasian faces and Chinese faces on native speakers of Mandarin-Chinese acquiring emotional connotations of English L2 words. Participants were presented with English pseudowords repeatedly paired with either Caucasian faces or Chinese faces showing the emotions of disgust and sadness, as well as neutrality as the control baseline. Participants’ acquisition was evaluated through both within-modality (i.e., testing participants with new sets of faces) and cross-modality (i.e., testing participants with a set of sentences expressing the emotions acquired) generalization tests. Results of the two generalization tests suggested that participants in the Caucasian-face Group acquired sad connotations better than their counterparts in the Chinese-face Group, which is reflected through their higher accuracy when matching learned L2 words with sad L2 sentences. We thus conclude that foreign faces showed a certain advantage when it comes to acquiring specific emotional connotations for L2 words with which their socio-identity is congruent.
Efficacy and Safty analysis of low-energy X ray IORT in the treatment of resectable pancreatic cancer
Authors: Sun Di , Liu Xu , Dong Wei , Zhang Qian , Zhang Yubao , Zhao Chunbo 
Published: February 2024

Abstract

Objective: This study was to investigate the safety and the efficacy of low-energy X-ray intraoperative radiotherapy(LEX-IORT) in the clinical treatment of resectable pancreatic cancer.
Method: We retrospectively analyzed the clinical information of the 88 patients with resectable pancreatic cancer in our hospital from 2011 to 2018. According on postoperative adjuvant regimen, The patients were divided into four subgroups. Chi-square test was used to analyze survival among subgroups. Kaplan-Meier method was used to estimate the survival rate. meanwhile, we compared complications, acute and chronic radiation injury, adverse reactions. P<0.05 was considered statistically significant.
Result: Group A: 14 patients, Only operation; Group B: 25 patients, Surgery+postoperative chemotherapy; Group C: 28 patients, Surgery+LEX-IORT; Group D: 21 patients, Surgery+postoperative chemotherapy and external irradiation. Subgroup analysis showed that increased chemotherapy extended survival compared with surgery alone (median OS: 7 months vs 11 months, p=0.0002). In addition to chemotherapy, LEX-IORT significantly improved PFS ( 8 months vs 11.5 months, p=0.0061) and OS ( 11 months vs 16.5 months, p=0.0113). Increasing EBRT did not improve outcomes.
Summary: Surgical resection combined with LEX-IORT and postoperative chemotherapy can increase the local control rate, significantly prolong the survival of patients, and does not increase the incidence of related complications and adverse reactions.
Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells
Authors: Crossey Erin , Carty Senegal , Shao Fengzhi , Henao-Vasquez Jhonatan , Ysasi Alexandra B. , Zeng Michelle , Hinds Anne , Lo Ming , Tilston-Lunel Andrew , Varelas Xaralabos , Jones Matthew R. , Fine Alan 
Published: February 2024

Abstract

The lymphatic system consists of a vessel network lined by specialized lymphatic endothelial cells (LECs) that are responsible for tissue fluid homeostasis and immune cell trafficking. The mechanisms for organ-specific LEC responses to environmental cues are not well understood. We found robust lymphangiogenesis during influenza A virus infection in the adult mouse lung. We show that the number of LECs increases 2-fold at 7 days post-influenza infection (dpi) and 3-fold at 21 dpi, and that lymphangiogenesis is preceded by lymphatic dilation. We also show that the expanded lymphatic network enhances fluid drainage to mediastinal lymph nodes. Using EdU labeling, we found that a significantly higher number of pulmonary LECs are proliferating at 7 dpi compared to LECs in homeostatic conditions. Lineage tracing during influenza indicates that new pulmonary LECs are derived from preexisting LECs rather than non-LEC progenitors. Lastly, using a conditional LEC-specific YAP/TAZ knockout model, we established that lymphangiogenesis, fluid transport and the immune response to influenza are independent of YAP/TAZ activity in LECs. These findings were unexpected, as they indicate that YAP/TAZ signaling is not crucial for these processes.
Prevalence of Diabetes and its Associated Factors among Adults in Malaysia: Findings from the National Health and Morbidity Survey 2019
Authors: Ismail Hasimah , Saminathan Thamil Arasu , Lourdes Tania Gayle Robert , Hasani Wan Shakira Rodzlan , Majid Nur Liana Abd , Yusoff Muhammad Fadhli Mohd 
Published: February 2024

Abstract

Background
Diabetes is a major non-communicable health problem in both developed and developing countries, including Malaysia. People with diabetes are living longer and are vulnerable to microvascular and macrovascular complications, thus representing a significant public health problem with high morbidity, mortality, and substantial economic repercussions. We aim to determine the national prevalence of diabetes and identify associated factors among the adult population in Malaysia.
Methods
A nationwide cross-sectional study was conducted in 2019 involving 10,464 respondents in Malaysia. A two-stage stratified sampling design was used to select a representative sample of Malaysian adults. Structured validated questionnaires with face-to-face interviews were used to obtain data from selected respondents aged ≥ 18. Finger-pricked fasting blood glucose tests using the Accutrend GC machine were performed on respondents who claimed they did not have diabetes. Chi-square tests and logistic regression were used to determine associations between diabetes and associated factors at the significance level of = 0.05.
Results
The overall prevalence of diabetes among adult respondents was 18.3% (n = 2629). The highest prevalence of diabetes was among females (18.4%), those aged 60 & above (41.5%), Indian (31.4%), those without formal education (28.3%), widow/widower/divorce (33.2%), not working (24.9%), inactive (22.5%), obese (27.1%), hypertension (36.0%) and high cholesterol level (30.4%). Logistic regression analyses revealed that age group, ethnicity, education level, marital status, physical activity level, obesity, blood pressure status and cholesterol status were associated with diabetes among adults.
Conclusion
This study showed that the prevalence of diabetes among adult populations in Malaysia is high, with about one in five adults found to have diabetes. Awareness programs and interventions on diabetes need to be improved, especially related to behavioural charge as a strategy for the prevention and control of diabetes and its complications.
Inhibition of discoidin domain receptor 1 (DDR1) as a new therapeutic strategy for osteosarcoma
Authors: Wang Jinglu , Walker Robert L. , Hornicek Francis J. , Shi Huirong , Duan Zhenfeng 
Published: February 2024

Abstract
Osteosarcoma is the most common type of bone cancer. Some patients eventually develop recurrent or metastatic diseases and treatment options are extremely limited. Discoidin domain receptor 1 (DDR1) is a unique collagen-activated tyrosine kinase that participates in various human diseases, including cancer. DDR1 promotes adhesion, proliferation, differentiation, migration, and metastasis of cancer cells. However, the expression and function of DDR1 remain unknown in osteosarcoma. The purpose of this study is to assess the expression, clinical prognostic relationship and functional roles of DDR1 in osteosarcoma. The correlation between DDR1 expression in tumor tissues and clinicopathological features, and prognosis was assessed via immunohistochemical staining of a unique tissue microarray (TMA) constructed from osteosarcoma specimens. DDR1-specific siRNA and a highly selective DDR1 inhibitor, 7rh, were applied to determine the impact of DDR1 expression on osteosarcoma cell growth and proliferation. Furthermore, the effect of DDR1 inhibition on clonogenicity was evaluated using a clonogenic assay, and a 3D cell culture model was used to mimic DDR1 effects in an in vivo environment. The results demonstrate that higher DDR1 expression significantly correlates with recurrence, metastasis, and shorter overall survival in osteosarcoma patients. The expression of DDR1 is also inversely correlated to the response to neoadjuvant chemotherapy. Therapeutically, DDR1 knockdown with siRNA or selective inhibition with 7rh decreases the proliferation and growth of osteosarcoma cells. In conclusion, our study supports DDR1 expression as an independent predictor of poor prognosis and a promising therapeutic target for osteosarcoma.
Association of cigarette use with risk of prostate cancer among US males: a cross-sectional study from NHANES 1999-2020
Authors: Yang Xiangwei , Chen Hong , Zhang Junfu , Zhang Shiqiang , Wu Yongda Socrates , Pang Jun 
Published: February 2024

Abstract

Background
Association of cigarette use with risk of prostate cancer remains unclear. We performed this study to examine whether cigarette use is associated with increased risk of prostate cancer.
Methods
This cross-sectional study used data from the 1999 to 2020 National Health and Nutrition Examination Survey (NHANES), a population-based nationally representative survey designed to assess the health and nutritional status of US adults and children. Males were eligible if they were aged ≥ 20 years at the time of participation. Cigarette use (ever use, categorized into former use and current use) was defined as having smoked at least 100 cigarettes in life. Smoking duration was calculated in former smokers and current smokers. Primary outcome was self-reported diagnosis of prostate cancer by participants. Logistic regression was used to calculate the adjusted odd ratios (aOR) and 95% CI for the associations of cigarette use with risk of prostate cancer, adjusting for demographic characteristics. Subgroup analyses by age group were conducted. Data were analyzed from June 4 to November 30, 2023.
Results
Of the 107 622 participants in 1999–2020 NHANES, 28 170 were included in the analysis. The mean (SD) age of the 28 170 participants was 46.4 (16.4) years, 68.0% were non-Hispanic White. Compared with never smokers, ever (aOR, 2.23 [95% CI, 1.06–4.68]) and former smokers (aOR, 3.54 [95% CI, 1.60–7.79]), but not current smokers (aOR, 1.04 [95% CI, 0.38–2.85]) had a higher risk of prostate cancer. This higher risk in former (aOR, 3.81 [95% CI, 1.69–8.59) and ever smokers (aOR, 2.77 [95% CI, 1.25–6.13) was also found in participants aged 20–59 years. But a lower risk was observed in current smokers aged ≥ 60 years (aOR, 0.52 [95% CI, 0.32–0.84). Dose-response analysis showed a positive association between smoking duration and risk of prostate cancer in current smokers (aOR, 1.07 [95% CI, 1.03–1.11]) but not in former smokers (aOR, 1.00 [95% CI, 0.99–1.02]).
Conclusions
This study suggests that cigarette use was associated with an increased risk of prostate cancer in US males, especially among those aged 20–59 years. This modifiable risk factor represents a target for further research into preventing prostate cancer in males.
Antimicrobial action, cytotoxicity, cleaning ability and erosive potential of Dentaqua solution compared with sodium hypochlorite
Authors: Souza Matheus Albino , Steier Liviu , Vanin Gabriele Nichetti , Zanella Mylena Lazaretti , Pizzi Camila Monteiro , Koch Jordana da Silva , souza kellyn Rocca , Ferreira Eduarda Rizzon , Dallepiane Felipe Gomes , Costa Ubirajara Maciel da , Santos Vanessa Valgas dos , Palatynska-Ulatowska Aleksandra , de Figueiredo José Antonio Poli 
Published: February 2024

Abstract

Objectives: This study aimed to compare the antimicrobial action, cytotoxicity, cleaning ability, and erosion of dentine of hypochlorous acid (HClO) obtained from an electrolytic device at two different concentrations (Dentaqua) and three concentrations of sodium hypochlorite (NaOCl).
Methods: Microbiological test - The root canals of sixty single-rooted extracted human teeth were inoculated with Enterococcus faecalis and divided into 6 groups (n=10), according to decontamination protocol: DW (control); 1% NaOCl; 2.5% NaOCl; 5.25% NaOCl; 250 ppm HClO and 500 ppm HClO. The counting of colony-forming units evaluated the decontamination potential of each group, calculating the bacterial percentage reduction. Cytotoxicity test - Cytotoxicity was evaluated after inoculation of the same tested protocols in fibroblastic cells for 3 min, calculating the cell viability percentages. Specifical statistical analysis was performed (α = 5%). Cleaning ability and erosion - Fifty-six single-rooted bovine lower incisors were divided into seven groups of 8 roots each, being the test groups 1% NaOCl; 2.5% NaOCl; 5,25% NaOCl; 250 ppm HClO and 500 ppm HClO, and a negative and positive control. Negative control was not contaminated, and the other groups were inoculated with Enterococcus faecalis. SEM images were ranked as from the cleanest to the least clean. Erosion was also assessed, being ranked from the least to the most eroded dentine.
Results: The highest bacterial reduction was observed in experimental groups, with no statistical differences between them (p > 0.05). The highest number of viable cells was observed in control group, followed by 250 ppm HClO and 500 ppm HClO groups, with statistical differences between them (p < 0.05). 1% NaOCl; 2.5% NaOCl; 5.25% NaOCl and 500 ppm HClO displayed the cleanest areas. All sodium hypochlorite groups displayed erosion with higher ranks with greater concentration, while hypochlorous acid did not display any erosion regardless the concentration.
Conclusions: It is possible to conclude that HClO obtained from an electrolytic device presented high antimicrobial activity and low cytotoxicity in both tested concentrations. 500 ppm HClO did not display erosion and showed great cleaning ability.
Clinical relevance: The use of 500 ppm hypochlorous acid may reduce unfavorable behavior of sodium hypochlorite whilst maintaining its antimicrobial action.