bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothyroidism in head and neck cancer patients: Experimental and clinical observations
Authors: Cannon C. Ron 
Published: October 2006

AbstractDamage to the thyroid gland may occur in patients undergoing treatment for head and neck neoplasms. This injury may result from damage incurred during surgery, from radiation therapy, or a combination of the two. Development of hypothyroidism is often insidious with potential harmful effects.An experimental study was performed to study the effects of hypothyroidism in pigs whose skin closely approximates that of the human. Wound tensile strength and flap necrosis were studied in the hypothyroid animal treated by surgery, radiation, and a combination of the two. The results of this study indicate that hypothyroidism alone has no significant unfavorable impact on wound tensile strengths or flap survival. When combined with preoperative radiation, however, there are statistically significant deleterious effects on both wound tensile strengths and flap survival. Histologically, collagen fibers within the wound appear shorter and thinner, which probably accounts for decreased wound tensile strengths.A clinical review of 62 head and neck cancer patients was also conducted. Within the study group, 10% of patients developed abnormally low thyroxine measurements, whereas 15% developed high thyroid‐stimulating hormone levels as the only evidence of early primary hypothyroidism. Hypothyroidism was not statistically related to tumor size, nodal status, clinical staging, or treatment group (surgery alone, radiation alone, or combination surgery and radiation). A previously unreported finding is that patients who develop a second primary tumor are significantly at risk for developing hypothyroidism.All patients diagnosed with a head and neck cancer should undergo baseline thyroid function testing, including measurement of TSH, and have serial repeat testing after treatment. Thyroid function determination should be mandatory in patients undergoing oncologic salvage procedures or treatment of a second primary tumor.
The Development and Testing of a Performance Checklist to Assess Neonatal Resuscitation Megacode Skill
Authors: Lockyer Jocelyn , Singhal Nalini , Fidler Herta , Weiner Gary , Aziz Khalid , Curran Vernon 
Published: October 2006

PURPOSE. The purpose of this work was to develop and assess the feasibility, reliability, and validity of a brief performance checklist to evaluate skills during a simulated neonatal resuscitation (“megacode”) for the Neonatal Resuscitation Program of the American Academy of Pediatrics.
METHODS. A performance checklist of items was created, validated, and modified in sequential phases involving: an expert committee, review, and feedback by Neonatal Resuscitation Program instructors for feasibility and criticality and use of the performance checklist by Neonatal Resuscitation Program instructors reviewing videotaped megacodes. The final 20-item performance checklist used a 3-point scale and was assessed by student and instructor volunteers. Megacode scores, the NRP multiple-choice examination scores, student assessments of their ability and performance, and sociodemographic descriptors for both students and instructors were collected. Data were analyzed descriptively. In addition, we assessed the megacode score internal consistency reliability, the correlations between megacode and multiple-choice examination scores, and the variance in scores based on instructor and student characteristics.
RESULTS. A total of 468 students and 148 instructors volunteered for the study. The instrument was reliable and internally consistent. Student's scores were high on most items. There was a significant but low correlation between the megacode score and the written knowledge examination. Instructor and student characteristics had little effect on the variance in scores.
CONCLUSIONS. This performance checklist provides a feasible assessment tool. There is evidence for its reliability and validity.
Clinical Value of Immunoglobulin A Antitransglutaminase Assay in the Diagnosis of Celiac Disease
Authors: Diamanti Antonella , Colistro Franco , Calce Angelica , Devito Rita , Ferretti Francesca , Minozzi Antonio , Santoni Alexandra , Castro Massimo 
Published: October 2006

OBJECTIVES. Our goal was to evaluate the possible correspondence between antitissue transglutaminase of immunoglobulin A class levels and stage of mucosal damage in patients affected by celiac disease. In addition, we assessed clinical use of antitissue transglutaminase values to predict biopsy results.
METHODS. One thousand eight hundred eighty-six consecutive patients with symptoms suggestive of celiac disease and 305 healthy controls underwent determination of serum levels of immunoglobulin A and antitissue transglutaminase. An intestinal biopsy was performed in subjects with antitissue transglutaminase levels ≥4 IU/mL and in subjects with negative antitissue transglutaminase levels but with clinical suspicion of celiac disease. Histologic grading of celiac disease was consistent with the Marsh classification.
RESULTS. One hundred eighty-six subjects with positive antitissue transglutaminase levels and 91 patients with negative antitissue transglutaminase levels were submitted to biopsy. In all healthy subjects, antitissue transglutaminase results were negative. Histologic evaluations in patients with positive antitissue transglutaminase levels gave the following results: type 0 in 25 patients, type 1 in 3 patients, type 2 in 4 patients, type 3a in 22 patients, type 3b in 74 patients, and type 3c in 58 patients. None of the patients with negative antitissue transglutaminase levels showed histologic findings suggestive of celiac disease. The mean antitissue transglutaminase values in patients without mucosal atrophy were significantly lower than in patients with mucosal atrophy. Antitissue transglutaminase values ≥20 IU/mL were found in only 1 patient without mucosal atrophy.
CONCLUSIONS. Our study found a strong correspondence between antitissue transglutaminase levels and stage of mucosal injury; antitissue transglutaminase values &gt;20 IU/mL seemed to be strongly predictive of mucosal atrophy.
Increasing Prevalence of Cerebral Palsy Among Very Preterm Infants: A Population-Based Study
Authors: Vincer Michael J. , Allen Alexander C. , Joseph K. S. , Stinson Dora A. , Scott Heather , Wood Ellen 
Published: October 2006

OBJECTIVES. It is unclear whether declines in neonatal and infant mortality have led to changes in the occurrence of cerebral palsy. We conducted a study to examine and investigate recent temporal changes in the prevalence of cerebral palsy in a population-based cohort of very preterm infants who were 24 to 30 weeks of gestational age.METHODS. A population-based cohort of very preterm infants who were born between January 1, 1993, and December 31, 2002, was evaluated by the Perinatal Follow-up Program of Nova Scotia. Follow-up extended to age 2 years to ascertain the presence or absence of cerebral palsy and for overall survival. Infant survival and cerebral palsy rates were compared by year and also in two 5-year periods, 1993–1997 and 1998–2002. Logistic regression analyses were used to identify factors that potentially were responsible for temporal changes in cerebral palsy rates.RESULTS. A total of 672 liveborn very preterm infants were born to mothers who resided in Nova Scotia between 1993 and 2002. Infant mortality among very preterm infants decreased from 256 per 1000 live births in 1993 to 114 per 1000 live births in 2002, whereas the cerebral palsy rates increased from 44.4 per 1000 live births in 1993 to 100.0 per 1000 live births in 2002. Low gestational age, postnatal dexamethasone use, patent ductus arteriosus, severe hyaline membrane disease, resuscitation in the delivery room, and intraventricular hemorrhage were associated with higher rates of cerebral palsy, whereas antenatal corticosteroid use was associated with a lower rate.CONCLUSION. Cerebral palsy has increased substantially among very preterm infants in association with and possibly as a consequence of large declines in infant mortality.
Expression of Matrix Metalloproteinases (MMP‐8 and ‐9) in Chronic Periodontitis Patients With and Without Diabetes Mellitus
Authors: Kumar Muthusamy Senthil , Vamsi Gelli , Sripriya Ramasamy , Sehgal Praveen Kumar 
Published: October 2006

Background:Matrix metalloproteinases (MMPs) are involved in a number of physiological events, and they are the major players in collagen breakdown during periodontal tissue destruction. Diabetes mellitus (DM) has been associated with altered collagen metabolism and increases the response of the periodontal tissue to pathogenic microorganisms, thereby increasing the severity of periodontal disease. The aim of this study was to assess the expression of MMP‐8 and ‐9 in gingival tissues of diabetic chronic periodontitis (CP), non‐diabetic CP, and healthy patients.Methods:The plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) were assessed. The levels of MMP expression in gingival tissue extracts were measured by gelatin zymography and Western blotting. The structural changes in tissues were analyzed by histological examination and collagen estimation.Results:Higher levels of PI, GI, CAL, and deeper PD were observed in CP patients with DM than CP patients without DM. The average concentration of MMP‐9 was increased three‐fold, and the MMP‐8 was increased two‐fold in CP patients with DM compared to CP patients without DM. A high infiltration of inflammatory cells and less collagen were observed in the histologic analysis of gingival biopsies from diabetic patients.Conclusions:An increased concentration of MMP‐8 and ‐9 in the gingival tissue of diabetic CP patients suggests that the expression of these MMPs contributes to the failure of the healing process in the diabetic condition. Treatment strategies directed toward the inhibition of these MMPs could lead to an improved healing rate in CP patients.
Matrix Metalloproteinase‐13 Is Highly Expressed in Destructive Periodontal Disease Activity
Authors: Hernandez Marcela , Valenzuela Maria Antonieta , Lopez‐Otin Carlos , Alvarez Jesús , Lopez Jose Manuel , Vernal Rolando , Gamonal Jorge 
Published: October 2006

Background: Matrix metalloproteinases (MMPs) participate in extracellular matrix degradation in physiological and pathological conditions. The available evidence suggests that MMP‐13 plays a significant role in both the initiation and progress of bone resorption. The aim of our study was to identify the presence of MMP‐13 in adult patients with untreated chronic periodontitis. We also determined the activity of MMP‐13 present in lesions undergoing episodic attachment loss in gingival crevicular fluid (GCF) samples.Methods: After monitoring at 2 and 4 months, 21 patients showed destructive periodontitis (periodontally affected sites presenting at least two sites with ≥2 mm clinical attachment loss), and GCF samples were collected both from active and inactive sites (21 GCF samples, each). GCF was collected during a 30‐second interval using a paper strip, and an immunofluorescence assay was performed to determine the basal activity of MMP‐13 and the relationship between 4‐aminophenylmercuric acetate (APMA)‐activated total MMP‐13 and basal MMP‐13 activity. Gingival tissues from five patients were fixed in formalin and MMP‐13 expression was demonstrated using immunohistochemistry and in situ hybridization. MMP‐13 molecular forms were examined by Western immunoblotting with monoclonal antibodies.Results: MMP‐13 was found in 100% of GCF samples from patients with chronic periodontitis. Active sites, associated with tissue destruction, had significantly higher proportions of active MMP‐13 and MMP‐13 activity levels than their inactive counterparts (1.49 versus 1.17 ng fluorescent product, respectively; P <0.05). Western blot, immunohistochemical staining, and in situ hybridization confirmed the presence of MMP‐13 in periodontal disease, with observable differences between periodontitis and healthy subjects. MMP‐13 immunoreactivities were seen mainly as 55 and 48 kDa, corresponding to partially and fully activated forms, respectively, and a smaller proportion of 60‐kDa proenzyme form.Conclusion: MMP‐13 activity in GCF samples was significantly increased in active sites from progressive periodontal disease, supporting its role in the alveolar bone loss developed in this disease.
Treatment of Intrabony Defects With an Enamel Matrix Protein Derivative or Bioabsorbable Membrane: An 8‐Year Follow‐Up Split‐Mouth Study
Authors: Sculean Anton , Schwarz Frank , Miliauskaite Asta , Kiss Alice , Arweiler Nicole , Becker Jürgen , Brecx Michel 
Published: October 2006

Background: Treatments with either an enamel matrix protein derivative (EMD) or guided tissue regeneration (GTR) have been shown to promote periodontal regeneration. However, until recently, only limited data have been available on the long‐term clinical results following these regenerative techniques. Therefore, the aim of this study was to present the 8‐year results of a prospective, controlled, split‐mouth clinical study evaluating the treatment of intrabony defects with EMD or GTR.Methods: Ten patients, each of whom displayed one pair of intrabony defects located contralaterally in the same jaw, were randomly treated with EMD or with GTR by means of bioabsorbable membranes. The following clinical parameters were evaluated at baseline and at 1 and 8 years after treatment: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR), and clinical attachment level (CAL). The primary outcome variable was CAL. No statistically significant differences between the groups were found at baseline.Results: The sites treated with EMD demonstrated a mean CAL change from 9.5 ± 1.2 mm to 6.3 ± 1.3 mm (P <0.001) and 6.7 ± 1.6 mm (P <0.001) at 1 and 8 years, respectively. No statistically significant differences were found between the 1‐ and 8‐year results. Sites treated with GTR showed a mean CAL change from 9.7 ± 1.3 mm to 6.7 ± 0.9 mm (P <0.001) at 1 year and 6.8 ± 1.2 mm (P <0.001) at 8 years. The CAL change between 1 and 8 years did not present statistically significant differences. Between the treatment groups, no statistically significant differences in any of the investigated parameters were observed at 1 and at 8 years. However, the study does not have the statistical power to rule out the possibility of a difference between the two groups.Conclusions: Within their limits, the present results indicate the following: 1) the clinical improvements obtained following treatment with EMD or GTR can be maintained over a period of 8 years; and 2) further studies of much higher power need to be performed to support equivalence.
In Vitro Sealing Ability of Two Materials at Five Different Implant‐Abutment Surfaces
Authors: Duarte Antonio R.C. , Rossetti Paulo H.O. , Rossetti Leylha M.N. , Torres Sergio A. , Bonachela Wellington C. 
Published: October 2006

Background: The aim of the present study was to test the sealing ability of two materials at five different implant‐abutment surfaces.Methods: In the first phase, 2 μl brain‐heart infusion (BHI) broth was deposited into the implant wells and glass culture tubes. A varnish or silicon sealant was applied at the cervical implant portion of experimental groups. The control group remained unexposed. The abutments were torque‐tightened to 20 Ncm with a manual torque driver. Implants were immersed in 4 ml BHI broth at 37°C for 2 hours to exclude contamination. In the second phase, 100 μl Enterococcus faecalis American Type Culture Collection (ATCC) strain 29212 was deposited into the glass culture tubes. After periods of 7, 14, 21, 35, 49, and 63 days, the sealing capacity was checked. Abutments were removed, and a sterile paper cone collected material inside implant bodies. This material was transferred to new tubes with BHI to verify the presence of cloudy broths within 24 to 48 hours.Results: There were no statistically significant differences between the two materials for each time period (Fisher exact test; P >0.05). Group E showed the least level of sealing ability (six implants contaminated), whereas group T showed the highest level (only two implants).Conclusions: 1) Materials tested were not able to prevent contamination over 63 days. 2) Bacterial contamination was verified after 14 and 35 days in the control and experimental groups, respectively. 3) Although materials tested had demonstrated similar sealing capacities, dental implants showed bacterial contamination regardless of their external or internal hexagonal configurations.
Polymorphism in Crystalline Cinchomeronic Acid
Authors: Braga Dario , Maini Lucia , Fagnano Concezio , Taddei Paola , Chierotti Michele R. , Gobetto Roberto 
Published: October 2006

AbstractThe structural relationship between the two crystal forms of cinchomeronic acid (CA 3,4‐dicarboxypyridine) has been investigated by single crystal X‐ray diffraction, IR and Raman spectroscopy and solid state NMR spectroscopy, showing that the two polymorphs form a monotropic system, with the orthorhombic form I being the thermodynamically stable form, while the monoclinic form II is unstable. In both forms CA crystallizes as a zwitterion and decomposes before melting. The crystal structure and spectroscopic analysis indicate that the difference in stability can be ascribed to the strength of the hydrogen‐bonding patterns established by the protonated N‐atom and the carboxylic/carboxylate O‐atoms.
Amination of [60]Fullerene by Ammonia and by Primary and Secondary Aliphatic Amines—Preparation of Amino[60]fullerene Peroxides
Authors: Hu Xiangqing , Jiang Zhongping , Jia Zhenshan , Huang Shaohua , Yang Xiaobing , Li Yuliang , Gan Liangbing , Zhang Shiwei , Zhu Daoben 
Published: October 2006

AbstractAmmonia and aliphatic amines react readily in the oxygen‐rich regions of the Cs symmetric fullerene peroxides C60(O)(OOtBu)4 (1) and C60(OH)(Br)(OOtBu)4 (2 c). Michael addition‐type hydroamination of the 1,4‐diene moiety on the central skew‐pentagon was observed when 1 was treated with ammonia or with nonbulky primary amines, while sterically demanding primary amines opened the epoxy moiety to form vicinal aminohydroxy fullerene compounds with the amino group on the central pentagon. In 2 c the bromo group was replaced under similar conditions by ammonia and primary amines. Cyclic secondary amines showed different reaction patterns, forming hydrogenation products or aminoketal‐fullerenes when treated with 1 and 2 c, respectively. Single‐electron transfer (SET) is the key step in all the proposed mechanisms. The compounds were characterized by their spectroscopic data, and in addition, three single‐crystal X‐ray structures were obtained.
Structural, Magnetic, and Spectroscopic Studies of YAgSn, TmAgSn, and LuAgSn.
Authors: Sebastian C. Peter , Eckert Hellmut , Fehse Constanze , Wright Jon P. , Attfield J. Paul , Johrendt Dirk , Rayaprol Sudhindra , Hoffmann Rolf‐Dieter , Poettgen Rainer 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bi3+/M2+ Oxyphosphate: A Continuous Series of Polycationic Species from the 1D Single Chain to the 2D Planes. Part 2. Crystal Structure of Three Original Structural Types Showing a Combination of New Ribbon‐like Polycations.
Authors: Colmont Marie , Huve Marielle , Mentre Olivier 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure, Electronic Structure and Physical Properties of the New Low‐Valent Thallium Silicon Telluride Tl6Si2Te6 in Comparison to Tl6Ge2Te6.
Authors: Assoud Abdeljalil , Soheilnia Navid , Kleinke Holger 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Mercury Chromates Hg6Cr2O9 and Hg6Cr2O10 — Preparation and Crystal Structures, and Thermal Behavior of Hg6Cr2O9.
Authors: Weil Matthias , Stoeger Berthold 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Friedel—Crafts‐type Cyclization of 2,2‐Difluorovinyl Ketones via α‐Fluorocarbocations and Its Application in Domino Cyclizations.
Authors: Ichikawa Junji , Kaneko Mikio , Yokota Misaki , Itonaga Masaaki , Yokoyama Takaharu 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave Irradiation Assisted Facile Synthesis of New Imidazole, Pyrazine, and Benzodiazocine Derivatives Using Diaminomaleonitrile (I).
Authors: El‐Shaieb Kamal M. 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tuning the Oxidation Properties of Vanadium(V) Through Ligand Stoichiometry.
Authors: Zeng Wei , Ballard T. Eric , Melander Christian 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pd/C—Et3N‐Mediated Catalytic Hydrodechlorination of Aromatic Chlorides under Mild Conditions.
Authors: Monguchi Yasunari , Kume Akira , Hattori Kazuyuki , Maegawa Tomohiro , Sajiki Hironao 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Potassium Fluoride/Basic Alumina as Far Superior Heterogeneous Catalyst for the Chemoselective Conjugate Addition of Nitroalkanes to Electron‐Poor Alkenes Having Two Electron‐Withdrawing Groups in α‐ and β‐Positions.
Authors: Ballini Roberto , Palmieri Alessandro 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iron(III)—Zirconium(IV) Combined Salt Immobilized on N‐(Polystyrylbutyl)pyridinium Triflylimide as a Reusable Catalyst for a Dehydrative Esterification Reaction.
Authors: Nakamura Yuka , Maki Toshikatsu , Wang Xiaowei , Ishihara Kazuaki , Yamamoto Hisashi 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unusual Reaction of Endic Anhydride with 2‐Methyl‐2‐phenylaminopropanenitrile.
Authors: Pal'chikov V. A. , Tarabara I. N. , Kol'tsov N. Yu. , Kas'yan L. I. 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Some New Tertiary Amines and Their Application as Co‐Catalysts in Combination with L‐Proline in Enantioselective Baylis—Hillman Reaction Between o‐Nitrobenzaldehyde and Methyl Vinyl Ketone.
Authors: Tang Hongying , Zhao Guofeng , Zhou Zhenghong , Zhou Qilin , Tang Chuchi 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.