bluuebunny/crossref_metadata_2025_split huggingface dataset:
SVHRSP alleviates age-related cognitive deficiency by reducing oxidative stress and neuroinflammation through Sirt 1 pathway
Authors: Wang Ying-zi , Wang Zhen-Hua , Guo Song-Yu , Li Qi-Fa , Kong Yue , Sui Ao-Ran , Ma Jian-Mei , Lu Li , Zhao Jie , Li Shao 
Published: March 2024

Abstract
Background
Our previous studies have shown that Scorpion venom heat-resistant synthesized peptide (SVHRSP) exhibits a significant extension in lifespan and improve in age-related physiological functions in worms. However, the mechanism underlying the potential anti-aging effects of SVHRSP in mammals remains elusive.
Methods
After conducting behaviour test, brain tissues were collected for morphological analysis, electrophysiology experiments, flow cytometry and protein or gene expression following SVHRSP treatment. H2O2-induced cell model was used to investigate the involvement of Sirt1 in the regulation of oxidative stress and inflammation mediated by SVHRSP.
Results
SVHRSP significantly ameliorated age-related cognitive decline, enhanced long-term potentiation, restored the synaptic loss, and upregulated the expression of synaptic proteins, thereby, indicating an improvement in synaptic plasticity. Moreover, SVHRSP demonstrated a decline in senescent markers, including SA-β-gal enzyme activity, p16, p12, Sirt1 and cell cycle arrest. The underlying mechanism involve an upregulation of antioxidant enzyme activity and a reduction in oxidative stress-induced damage. Furthermore, SVHRSP regulated the nucleoplasmic distribution of Nrf2 through sirt1-p53 pathway. Further research indicated that a reduction in the expression of pro-inflammatory factor in the brain after SVHRSP treatment. SVHRSP attenuated neuroinflammation by regulating the NF-κB nucleoplasmic distribution and inhibiting microglia and astrocytes activation through Sirt1-NF-κB pathway. Additionally, SVHRSP significantly augmented Nissl bodies count while suppressing the neuronal loss.
Conclusion
SVHRSP could remarkably improve cognitive deficiency by inhibiting oxidative stress and neuroinflammation through the activation of Sirt 1 pathway, thus representing an effective strategy to improve brain health.
From project to planning: development and effectiveness of the water-draw and utilization assessment policy in China
Authors: Cheng Zhe , Xu Yue , Li Yun , Zhu Yixin , Guo Li 
Published: March 2024

ABSTRACT

The water-draw and utilization assessment (WDUA) policy is crucial for ensuring sustainable water development and good water governance in China. It consists of the WDUA in construction projects (WDUA-CP) and WDUA in urban planning (WDUA-UP). Based on a systematic review of the WDUA policy's development, this study evaluated the WDUA policy from the perspectives of policy text and implementation effectiveness using text-mining and statistical analysis methods. The results show that the WDUA policy is generally successful and has progressed across all regions in China. Despite existing regional gaps, effectiveness will continue to grow at the current situation of implementation. This study broadens the field of inquiry into China's water policy, enhances the method for assessing global water policy, and offers a fresh viewpoint for the international water community to understand China's integrated water resources management and water governance.
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer
Therapy
Authors: Bhattacharya Sankha , Beninger Paul 
Published: March 2024

Abstract:
This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs)
as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles,
pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized
as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based and metal)
varieties. A significant focus is placed on CMNPs, which serve as an innovative drug delivery vehicle, overcoming
limitations associated with conventional nanoparticle therapies. This manuscript accurately explores
the advantages and challenges of various cell membranes, including those derived from cancer cells, red blood
cells, platelets, stem cells, and white blood cells. Importance is placed on their roles in enhancing drug delivery
precision, immune system circumvention, and targeted recognition. Detailed insights into the crafting of
CMNPs are provided, elucidating membrane extraction and fusion techniques, such as sonication, extrusion,
co-extrusion, and microfluidic electroporation. Maintaining membrane integrity during extraction and the benefits
of coating techniques in augmenting biocompatibility and targeted drug delivery are underscored. This
comprehensive resource consolidates the latest advancements in targeted drug delivery, positioning itself at
the forefront of nanotechnology and biomedicine research. Encapsulating various methodologies like membrane
extrusion, electrospray, and chemical conjugation, this manuscript showcases the expanding toolbox
available to researchers in this dynamic field. Focusing on the unique characteristics of CMNPs, this review explores
their multifaceted applications in biomedical research, particularly in tumour therapy. It provides an indepth
analysis of the biocompatibility of CMNPs, their stability, immune evasion capabilities, targeted drug delivery
precision, increased payload capacity, and retained biological functionality. The manuscript outlines current
applications and future prospects of CMNPs in targeted chemotherapy, photothermal and photodynamic
therapy, immunotherapy, gene therapy, and innovative therapeutic methods. It concludes by highlighting the
advantages of CMNPs in tumour therapy and their transformative potential in reshaping the landscape of cancer
treatment.
Volatile Oil of Magnolia biondii Pamp. for Transnasal Administration: Its
Preparation, Characterization, and Mechanism of Action in the
Treatment of Allergic Rhinitis
Authors: Guo Qiuting , Wang Xuan , Wang Yao , Zhou Peijie , Zhang Xiaofei 
Published: March 2024

Background:
Allergic Rhinitis (AR) is a common chronic nasal condition usually
caused by allergens. The immune system overreacts when the body is exposed to allergens, releasing
a lot of tissue chemicals that cause congestion, more secretions, and an inflammatory reaction
in the nasal mucosa.

Method:
In clinical practice, it remains a significant public health issue. Modern pharmacological
studies have demonstrated that Magnolia Volatile Oil (MVO) has good anti-inflammatory, antibacterial,
immunomodulatory, and other pharmacological effects. Previous research and literature reports
have reported that MVO has good therapeutic effects on allergic rhinitis. However, due to
the poor water solubility of Magnolia, its bioavailability is low. The purpose of this present work
is to develop a new microemulsion formulation to improve the stability and bioavailability of
MVO.

Results:
The droplet size, PDI, and zeta potential of Magnolia volatile oil microemulsion (MVOME)
were characterized along with its physical characteristics, and these values were found to be
14.270.03 nm, 0.09410.31, and -0.35850.12 mV, respectively, demonstrating the successful formation
of microemulsion. In OVA-induced AR rats, MVO-ME dramatically reduced the serum levels
of TNF-α, IL-1β, and IL-6 inflammatory factors. In addition, MVO-ME significantly inhibited
the expression of protein levels of PPAR-γ and P65 in the nasal mucosa of AR rats. In this regard,
we hypothesized that MVO-ME may play a therapeutic role in AR by activating the PPAR signaling
pathway as well as inhibiting the activation of the NF/κB signaling pathway.

Conclusion:
MVO-ME has systematic advantages, such as high solubility, bioavailability, etc. It
is expected to be an efficient nano-drug delivery system for the clinical treatment of allergic rhinitis.
Cholesterol Absorption Inhibition by Some Nutraceuticals
Authors: Kumar Shivendra , Saha Sunam , Pathak Devender , Singh Talever , Kumar Atul , Singh Kuldeep , Mishra Avinash Kumar , Singh Sakshi , Singh Shubham 
Published: March 2024

:
Hyperlipidemia, characterized by elevated levels of lipids in the blood, represents a
major risk factor for cardiovascular diseases, a leading cause of morbidity and mortality worldwide.
Conventional pharmacological interventions have been effective in managing hyperlipidemia,
but concerns about side effects and long-term use have prompted interest in alternative
approaches, particularly the use of nutraceuticals. This comprehensive review aims to summarize
and critically evaluate the current body of knowledge surrounding the role of nutraceuticals
in the management of hyperlipidemia. We provide an overview of the different classes of
nutraceuticals, including plant sterols, omega-3 fatty acids, soluble fiber, antioxidants, and various
herbal extracts, which have been investigated for their lipid-lowering properties. The mechanisms
of action of these nutraceuticals are discussed, highlighting their ability to modulate lipid
metabolism, reduce oxidative stress, and promote cardiovascular health.

:
Furthermore, we review the results of clinical trials and epidemiological studies that have assessed
the efficacy of nutraceutical interventions in lowering cholesterol levels, improving lipid profiles,
and reducing the risk of cardiovascular events. In addition to their lipid-lowering effects, we examine
the safety profile, dosage recommendations, and potential interactions of nutraceuticals with
conventional lipid-lowering medications. We also address the importance of patient adherence to
dietary and lifestyle modifications in conjunction with nutraceutical supplementation. While
nutraceuticals offer a promising avenue for managing hyperlipidemia, we emphasize the need for
further research to establish evidence-based guidelines for their use in clinical practice. Challenges
related to standardization, quality control, and regulatory considerations are also discussed. In conclusion,
this comprehensive review provides valuable insights into the potential of nutraceuticals as
adjunctive or alternative therapies for managing hyperlipidemia. While further research is needed,
the accumulating evidence suggests that nutraceuticals can play a valuable role in promoting cardiovascular
health and reducing the burden of hyperlipidemia-related diseases.
Machine Learning–Based Approach for Identifying Research Gaps: COVID-19 as a Case Study
Authors: Abd-alrazaq Alaa , Nashwan Abdulqadir J , Shah Zubair , Abujaber Ahmad , Alhuwail Dari , Schneider Jens , AlSaad Rawan , Ali Hazrat , Alomoush Waleed , Ahmed Arfan , Aziz Sarah 
Published: March 2024

Background
Research gaps refer to unanswered questions in the existing body of knowledge, either due to a lack of studies or inconclusive results. Research gaps are essential starting points and motivation in scientific research. Traditional methods for identifying research gaps, such as literature reviews and expert opinions, can be time consuming, labor intensive, and prone to bias. They may also fall short when dealing with rapidly evolving or time-sensitive subjects. Thus, innovative scalable approaches are needed to identify research gaps, systematically assess the literature, and prioritize areas for further study in the topic of interest.

Objective
In this paper, we propose a machine learning–based approach for identifying research gaps through the analysis of scientific literature. We used the COVID-19 pandemic as a case study.

Methods
We conducted an analysis to identify research gaps in COVID-19 literature using the COVID-19 Open Research (CORD-19) data set, which comprises 1,121,433 papers related to the COVID-19 pandemic. Our approach is based on the BERTopic topic modeling technique, which leverages transformers and class-based term frequency-inverse document frequency to create dense clusters allowing for easily interpretable topics. Our BERTopic-based approach involves 3 stages: embedding documents, clustering documents (dimension reduction and clustering), and representing topics (generating candidates and maximizing candidate relevance).

Results
After applying the study selection criteria, we included 33,206 abstracts in the analysis of this study. The final list of research gaps identified 21 different areas, which were grouped into 6 principal topics. These topics were: “virus of COVID-19,” “risk factors of COVID-19,” “prevention of COVID-19,” “treatment of COVID-19,” “health care delivery during COVID-19,” “and impact of COVID-19.” The most prominent topic, observed in over half of the analyzed studies, was “the impact of COVID-19.”

Conclusions
The proposed machine learning–based approach has the potential to identify research gaps in scientific literature. This study is not intended to replace individual literature research within a selected topic. Instead, it can serve as a guide to formulate precise literature search queries in specific areas associated with research questions that previous publications have earmarked for future exploration. Future research should leverage an up-to-date list of studies that are retrieved from the most common databases in the target area. When feasible, full texts or, at minimum, discussion sections should be analyzed rather than limiting their analysis to abstracts. Furthermore, future studies could evaluate more efficient modeling algorithms, especially those combining topic modeling with statistical uncertainty quantification, such as conformal prediction.
High Intensity Interval Training (HIIT) dalam Meningkatkan Daya Tahan dan Mencegah Cedera pada Pemain Bulu Tangkis
Authors: Setiawan Cahyo , Jannah Suci Muqodimatul , Kurniawan Muhammad Dwi , Nurhayati Shahad Erma 
Published: March 2024

Latar Belakang: High-Intensity Interval Training (HIIT) merupakan latihan terbaik untuk meningkatkan daya tahan tubuh dan mencegah cedera. Latihan tersebut adalah latihan kardiovaskular yang menggabungkan latihan intensitas tinggi dalam dosis tertentu. Selain melakukan gerakan raket yang kompleks, pemain bulutangkis membutuhkan koordinasi motorik yang tinggi, stamina kardiovaskular, kelincahan, kekuatan, kecepatan, dan ketepatan. Pemain bulutangkis juga rentan mengalami cedera.Tujuan: Penelitian ini bertujuan untuk mengetahui efektifitas pemberian High-Intensity Interval Training untuk meningkatkan daya tahan dan mencegah cedera pada pemain bulutangkis.Metode: Penelitian ini merupakan penelitian kuasi eksperimen dengan desain one group study. Terdapat 15 pemain bulutangkis berusia antara 18 hingga 25 tahun yang berpartisipasi dalam penelitian ini. Paired t-test dilakukan untuk mengevaluasi efek pelatihan dan dianalisis menggunakan SPSS.Hasil: Hasil penelitian ini menunjukkan adanya peningkatan yang signifikan (p<0,05) dalam daya tahan atletik setelah HIIT dengan peningkatan 2,8% dalam kinerja ketahanan mereka. Ada juga efek yang signifikan (p<0,005) dalam pencegahan risiko cedera dengan rata-rata sebesar 1,1%.Kesimpulan: Penelitian ini menunjukkan bahwa program Latihan HIIT dapat memberikan efek yang signifikan dalam meningkatkan komponen fisik, terutama daya tahan, dan mencegah cedera.
Transformasi Ketahanan Wilayah pada Era Digital: Peran Kepemimpinan Digital dalam Membangun Smart City di Kota Pariaman Sumatera Barat
Authors: Hanita Margaretha 
Published: March 2024

ABSTRACT The digital revolution in public services is a response to the massive development of technology and information systems. The Government of Pariaman City has transformed into a smart city by developing various digital services. This research aims to analyze various digital services in Pariaman City to support the city's strategic leadership and digital leadership. The method used is phenomenology. Data used in this study are derived from literature reviews and observations on various developed applications. Data validation was carried out through triangulating observations, government documents and records, literature studies, member checking, and expert responses. The research results show that the Government of Pariaman City provides digital services in the form of applications/information systems and websites containing information and facilitating public access to public services. The utilization of digital services by the community eases the government's data collection process, including data related to population, economy, security, welfare, disasters, and civil servant performance. These data are used for the development planning of Pariaman City. In the context of regional resilience, Pariaman City can undergo rapid transformation through digitalization approaches. Therefore, the various digital services developed in Pariaman City greatly support the realization of regional resilience through digital leadership.
Along-Strike Variations of Alaska Subduction Zone Structure and Hydration Determined From Amphibious Seismic Data
Authors: Li Zongshan , Wiens Douglas A , Shen Weisen , Shillington Donna 
Published: March 2024

We develop a 3-D isotropic shear velocity model for the Alaska
subduction zone using data from seafloor and land-based seismographs to
investigate along-strike variations in structure. By applying ambient
noise and teleseismic Helmholtz tomography, we derive Rayleigh wave
group and phase velocity dispersion maps, then invert them for shear
velocity structure using a Bayesian Monte Carlo algorithm. For
land-based stations, we perform a joint inversion of receiver functions
and dispersion curves. The forearc crust is relatively thick (35-42 km)
and has reduced lower crustal velocities beneath the Kodiak and Semidi
segments, which may promote higher seismic coupling. Bristol Bay Basin
crust is relatively thin and has a high-velocity lower layer, suggesting
a dense mafic lower crust emplaced by the rifting processes. The
incoming plate shows low uppermost mantle velocities, indicating
serpentinization. This hydration is more pronounced in the Shumagin
segment, with greater velocity reduction extending to 18 ± 3 km depth,
compared to the Semidi segment, showing smaller reductions extending to
14 ± 3 km depth. Our estimates of percent serpentinization from
V reduction and V/V
are larger than those determined using V reduction in
prior studies, likely due to water in cracks affecting
V more than V. Revised estimates of
serpentinization show that more water subducts than previous studies,
and that twice as much mantle water is subducted in the Shumagin segment
compared to the Semidi segment. Together with estimates from other
subduction zones, the results indicate a wide variation in subducted
mantle water between different subduction segments.
Satisfaction and Self-Confidence of Nursing Students in Learning using 3D Simulators
Authors: Adawiyah Nabilah Al , Komariah Maria , Kosim Kosim 
Published: March 2024

Background: Face-to-face simulation requires a lot of resources, such as space, time, and cost. These obstacles encourage educators to look for learning technologies that can provide realistic learning opportunities and be accessed flexibly, one of which is by using virtual simulations such as 3D simulators. The effectiveness of 3D simulator as learning media can be assessed through student satisfaction and self-confidence.Aim: This study aims to identify nursing students' satisfaction and self-confidence in learning using 3D simulators.Method: The research design used was descriptive quantitative. The sampling technique used was purposive sampling with a sample of 67 nursing students. The instrument used was the Student Satisfaction and Self-Confidence in Learning Scale (SCSL). Data analysis was carried out using univariate analysis.Result: This study showed that students were very satisfied (M = 4.415; SD = 0.489) and very confident (M = 4.338; SD = 0.419) in learning using a 3D simulator.Conclusion: High satisfaction and self-confidence in using 3D simulators were obtained. The 3D simulator can be a supporting media that can be used in several nursing courses to prepare for practicum and as a medium for reviewing practicum that has been done. Keywords: 3D simulator, satisfaction, self-confidence, virtual simulation
The Use of E-Module Learning Media and Nursing Students’ Self Efficacy
Authors: Rahmawati Fitri Eka , Susanti Raini Diah , Mambang Sari Citra Windani 
Published: March 2024

There is a need for learning media innovation for students with pandemic conditions. The e-module learning media is part of the VnursLab 3D Simulator, consisting of 22 E-Modules and 3 E-Modules tested for effectiveness on student knowledge, satisfaction, and learning motivation. In this learning, media has a relationship with students' academic self-efficacy to achieve goals and overcome obstacles during learning. Purpose: Identifying an overview of the use of e-module learning media for Nursing students' self-efficacy. Method: This study uses a quantitative descriptive method with a cross-sectional approach using The College Academic Self Efficacy Scale (CASES) instrument, which has been carried out validation tests produced α>0.3 and a reliability of 0.931. This study used an e-module insertion catheter (Benign Prostatic Hyperplasia). The population of this study is active undergraduate nursing students level III at Padjadjaran University with purposive sampling totalling 110 students. Results: The results showed that the use of e-module learning media was dominated by self-efficacy results with a high category rather than a moderate category in nursing students. Conclusion: This concludes that respondent characteristics positively affect nursing students' self-efficacy, resulting in satisfactory academic achievement.
Factors Related to Nurses Caring Behavior in Inpatient Unit
Authors: Fitriani Rina , Wihardja Hany 
Published: March 2024

Caring is the essence of nursing practice. Caring is also an approach to increase a sense of caring for patients. This attitude can help patients achieve improved quality of recovery and health. Caring from the patient's point of view is a humane attitude expected by the patient. Caring is basically a nurse's behavior, so that caring basically depends on the characteristics and motivation of an individual nurse. This study aims to identify the factors that most influence the caring behavior of nurses in the inpatient room. Research methodology: This research is an analytic observational study with a Cross-sectional approach. The samples technique was total population of nurses that is 137 nurses. Three instrument used in this study : characteristic respondent, work motivation, Caring Nurse-Patient Interaction Scale (CNPI-23). Data analysis using Chi Square test, Kendall's Tau-b and Logistic Regression. The results of this study found that nurses' work motivation was the most influencing factor for nurses' caring behavior (p value 0.022). Nurses with high work motivation voluntarily perform their best efforts and skills when working and do not feel physical or mental pressure. As a result, they can show a sense of caring, empathy, and sensitivity to patients during nursing care. Further recommendation that can be given to hospital management are to pay attention to the creation of a motivational work climate, so that workers have high work motivation at work.