bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stabilization and Functionalization of Metallic Nanoparticles: the Peptide Route
Authors: Lévy Raphaël , Doty R. Christopher 
Published: September 2007

Abstract
The sections in this article are

Introduction

Metallic Nanoparticles – An Overview

Metallic Nanoparticles – Preparation

Metallic Nanoparticles – Optical Properties

Metallic Nanoparticles – Applications

Stabilization and Functionalization of Metallic Nanoparticles – The Peptide Route

Peptides, Proteins and Nanoscale Science

Peptide Toolbox for Bionanotechnology

Peptides as Capping Ligands

Interactions of Amino Acids with Noble Metals

Peptides as Reducing Agent and Template in Metallic Nanoparticle Synthesis

Rational Design of a Peptide Capping Ligands for Gold Nanoparticles:
CALNN

Combinatorial Exploration of Peptides as Capping Ligands: the
CALNN
Family

Peptide‐capped Silver Nanoparticles

Peptides as Capping Ligands for Fluorescent and Magnetic Nanoparticles

Peptide Extensions to Introduce Functionalities

Biotin and Strep‐tag
II

Peptide‐
DNA
Hybrids

His‐tag and Nickel Nitrilotriacetic Acid (
Ni
‐
NTA
)

Chromatography of Peptide‐capped Nanoparticles

Size‐exclusion Chromatography

Affinity Chromatography

Recognition of Materials

Peptide‐based Linkers

A Peptide‐Peptide Linker Based on Leucine‐zipper Sequences

A Peptide‐
DNA
Linker Based on Metallopeptides

A Peptide‐
T
exas Red Linker Obtained by Phage Display

Biologically Active Peptides

Self‐assembling Peptides

Fibers and Nanotubes

Peptide‐based Amphiphiles

Concluding Remarks
Plant Protein‐based Nanoparticles
Authors: Orecchioni Anne‐Marie , Duclairoir Cécile , Irache Juan Manuel , Nakache Evelyne 
Published: September 2007

AbstractThe sections in this article areIntroductionDescription of Plant ProteinsPea Seed ProteinsWheat ProteinsPreparation of Protein NanoparticlesPreparation of Legumin and Vicilin NanoparticlesPreparation of Gliadin NanoparticlesDrug Encapsulation in Plant Protein NanoparticlesRAEncapsulation in Gliadin NanoparticlesVEEncapsulation in Gliadin NanoparticlesLipophilic, Hydrophilic or Amphiphilic Drug EncapsulationPreparation of Ligand–Gliadin Nanoparticle ConjugatesBioadhesive Properties of Gliadin NanoparticlesEx VivoStudies with Gastrointestinal Mucosal SegmentsIn VivoStudies with Laboratory AnimalsFuture PerspectivesSize OptimizationImmunization in AnimalsConclusion
Albumin Nanoparticles
Authors: Irache Juan Manuel , Espuelas Socorro 
Published: September 2007

AbstractThe sections in this article areIntroductionSerum AlbuminPreparation of Albumin Nanoparticles“Conventional” Albumin NanoparticlesPreparation of Albumin Nanoparticles by Desolvation or CoacervationPreparation of Albumin Nanoparticles by EmulsificationOther Techniques to Prepare Albumin NanoparticlesSurface‐modified Albumin NanoparticlesDrug Encapsulation in Albumin NanoparticlesBiodistribution of Albumin NanoparticlesPharmaceutical ApplicationsAlbumin Nanoparticles for Diagnostic PurposesRadiopharmaceuticalsEcho‐contrast AgentsAlbumin Nanoparticles as Carriers for Oligonucleotides andDNAAlbumin Nanoparticles in the Treatment of CancerFluorouracil and Methotrexate DeliveryPaclitaxel DeliveryAlbumin Nanoparticles in Suicide Gene TherapyMagnetic Albumin NanoparticlesAlbumin Nanoparticles for Ocular Drug DeliveryTopical Drug DeliveryIntravitreal Drug DeliveryConcluding Remarks
Methods of Preparation of Drug Nanoparticles
Authors: Lee Jonghwi , Lim Gio‐Bin , Chung Hesson 
Published: September 2007

AbstractThe sections in this article areIntroductionStructures of Drug NanoparticlesThermodynamic ApproachesLipid‐based Pharmaceutical NanoparticlesWhat is a Lipid?Liquid Crystalline Phases of Hydrated Lipids with Planar and Curved InterfacesOil‐in‐water‐type Lipid EmulsionLiposomesCubosomes and HexosomesOther Lipid‐based Pharmaceutical NanoparticlesMechanical ApproachesTypes of ProcessingCharacteristics of Wet ComminutionDrying of Liquid NanodispersionsSCFApproachesSCF CharacteristicsClassification ofSCFParticle Formation ProcessesRESSSASSEDSElectrostatic ApproachesElectrical Potential and InterfacesElectrospraying
Production of Biofunctionalized Solid Lipid Nanoparticles for Site‐specific Drug Delivery
Authors: Müller Rainer H. , Souto Eliana B. , Göppert Torsten , Gohla Sven 
Published: September 2007

AbstractThe sections in this article areIntroductionConcept of Differential AdsorptionProduction ofSLNFunctionalization by Surface ModificationConclusions
Characterization of Nanoscale Systems in Biology using Scanning Probe Microscopy Techniques
Authors: Coleman Anthony W. , Lazar Adina N. , Rousseau Cecile F. , Cecillon Sebastien , Shahgaldian Patrick 
Published: September 2007

AbstractThe sections in this article areIntroductionThe Scanning Probe Microscopy ExperimentScanning Tunneling Microscopy ImagingAtomic Force MicroscopyGeneralitiesTips and CantileversContact ModeAFMDynamic ModesGeneralitiesNon‐contact ModeIntermittent Contact ModeForce Modulation ModeFriction Force Mode or Lateral Force ModeForce–Distance AnalysisChemical Force ImagingDip‐pen LithographyCantilever Array SensorsNear‐field Scanning Optical MicroscopyArtifactsArtifacts Related to Tip Size and GeometryArtifacts from Damaged TipsArtifacts from Tip–Sample InteractionsSample ArtifactsUsing the ToolsDNATopographic Imaging ofDNAImagingDNATranslocationDNAInteractions and StretchingProteinsTopographic Imaging of ProteinsDip‐pen Nanolithography Patterning of ProteinsProtein–Protein and Protein–Ligand InteractionsPolysaccharidesProteoglycan Topographic ImagingLipid SystemsLiposomesSolid Lipid Nanoparticles (SLNs)Supported Lipid Bilayers and MonolayersSNOMImagingVirusesCellsTopographic ImagingInteractions and Mechanical PropertiesNSOMImagingCantilever Arrays as BiosensorsConclusionAcknowledgments
Quartz Crystal Microbalance Characterization of Nanostructure Assemblies in Biosensing
Authors: Gerdon Aren E. , Wright David W. , Cliffel David E. 
Published: September 2007

Abstract
The sections in this article are

Introduction

Principles of
QCM

QCM
Wave Penetration Depth

QCM
Sensor Specificity

Calculation of Equilibrium and Kinetic Constants

QCM
Application to Life Sciences

Interface Between Biology and Nanomaterials

Antibodies

Nanoparticles

QCM
Nanoparticle‐based Chemical Sensors

QCM
Nanoparticle‐based Biosensors

QCM
Nanoparticle‐based Immunosensors

Traditional Immunoassays

Immunoassays using Nanotechnology

QCM
Nanoparticle‐based Immunosensors

Antigen Mimic Design

Glutathione‐protected Nanocluster

Hemagglutanin Mimic Nanocluster

Protective Antigen of
B. anthracis
Mimic Nanocluster

Conclusions and Future Directions

Acknowledgments
In Situ
Characterization of Drug Nanoparticles by
FTIR
Spectroscopy
Authors: Türk Michael , Signorell Ruth 
Published: September 2007

Abstract
The sections in this article are

Introduction

Particle Generation Methods

Rapid Expansion of Supercritical Solutions (
RESS
)

Electro‐Spraying

Particle Characterization Methods

In Situ
Characterization with
FTIR
Spectroscopy

Experimental Setup

Characterization of the
RESS
Process

In Situ
Characterization with 3‐
WEM

Characterization with
SMPS
and
SEM

Determination of Refractive Index Data in the Mid‐infrared Region

Examples

Phenanthrene Particles: Size, Shape, Optical Data

Sugar Nanoparticles

Drug Nanoparticles

Summary and Conclusion

Acknowledgment
Dynamic Light Scattering Microscopy
Authors: Dzakpasu Rhonda , Axelrod Daniel 
Published: September 2007

AbstractThe sections in this article areIntroductionTheorySingle Scattering CenterMultiple Scattering CentersTemporal Autocorrelation of IntensityPhase Fluctuation FactorsNumber Fluctuation FactorsCharacteristic Times and DistancesSpatial Autocorrelation of IntensityVariance of Intensity Fluctuations: Mobile FractionExperimental DesignOptical SetupData AcquisitionSample Preparation: Polystyrene BeadsSample Preparation: Living MacrophagesBuffer Changes during Data AcquisitionData AnalysisTemporal Intensity Autocorrelation FunctionSpatial Intensity Autocorrelation FunctionMobile FractionExperimental ResultsPolystyrene Beads: Temporal Phase AutocorrelationVariance of Intensity Fluctuations on Beads: Phase FluctuationsPolystyrene Beads: Number FluctuationsPolystyrene Beads: Spatial AutocorrelationPolystyrene Beads: Mobile FractionsLiving Macrophage Cells: Temporal AutocorrelationLiving Macrophage Cells: Mobile FractionDiscussionPolystyrene BeadsMacrophagesImprovements forDLSMAcknowledgments
Protein‐based Nanotechnology: Kinesin–Microtubule‐driven Systems for Bioanalytical Applications
Authors: Hancock William O. 
Published: September 2007

AbstractThe sections in this article areIntroductionKinesin and Microtubule Cell Biology and BiophysicsKinesin Motility AssaysTheoretical Transport Issues for Device IntegrationDiffusion versus Transport TimesInteraction of Motor Proteins and Filaments with Synthetic SurfacesMotor AdsorptionMicrotubule ImmobilizationControlling the Direction and Distance of Microscale TransportDirecting Kinesin‐driven MicrotubulesMovement in Enclosed MicrochannelsImmobilized Microtubule ArraysCargo AttachmentMaximum Cargo SizeSystem Design ConsiderationProtein Stability and LifetimeSample Introduction and DetectionAnalyte Detection and CollectionConclusionAcknowledgments
Fullerene‐based Devices for Biological Applications
Authors: Sarova Ginka H. , Da Ros Tatiana , Guldi Dirk M. 
Published: September 2007

Abstract
The sections in this article are

Introduction

Solubility

Toxicity

DNA
Photocleavage

Photodynamic Therapy (
PDT
)

Fullerene‐mediated Electron Transfer Across Membranes

Neuroprotective Activity
via
Radical Scavenging

Enzyme Inhibition and Antiviral Activity

Antibacterial Activity

Fullerenes as Nanodevices in Monoclonal Immunology

Fullerenes as Radiotracers

Fullerenes as Vectors

Acknowledgments
Nanodevices in Nature
Authors: Volkov Alexander G. , Brown Courtney L. 
Published: September 2007

AbstractThe sections in this article areIntroductionMultielectron Processes in Bioelectrochemical NanoreactorsCytochrome Oxidase: A Nanodevice for RespirationNanodevice ArchitectonicsActivation Energy and Mechanism of Oxygen ReductionProton PumpPhotosynthetic Electrochemical Nanoreactors, Nanorectifiers, Nanoswitches and Biologically Closed Electrically CircuitsPhototropic Nanodevices in Green Plants: Sensing the Direction of LightMembrane Transport and Ion ChannelsMolecular MotorsNanodevices for Electroreception and Electric Organ DischargesNeurons
Possible Health Impact of Nanomaterials
Authors: Hoet Peter H. M. , Brüske‐Hohlfeld Irene , Salata Oleg V. 
Published: September 2007

Abstract
The sections in this article are

Introduction

Sources of Nanoparticles

Epidemiological Evidence

Entry Routes into the Human Body

Lung

Inhalation, Deposition and Pulmonary Clearing of Insoluble Solids

Biopersistence of Inhaled Solid Material

Systemic Translocation of Inhaled Particles

Intestinal Tract

Deposition and Translocation

Intestinal Translocation and Disease

Skin

Deposition and Penetration through the Skin

Irritation of Skin

What Makes Nanoparticles Dangerous?

Particle Size – Surface and Body Distribution

Effect of Size

Effect of Surface Charges

Nanoparticles, Thrombosis and Lung Inflammation

Prothrombotic Effect

Oxidative Stress, Inflammation and Endotoxins

Nanoparticles and Cellular Uptake

Nanoparticles and the Blood–Brain Barrier

Summary and Discussion

What Can be Done?
Impact of Ceramic and Metallic Nano‐scaled Particles on Endothelial Cell Functionsin vitro
Authors: Peters Kirsten , Unger Ronald E. , Gatti Antonietta M. , Sabbioni Enrico , Gambarelli Andrea , Kirkpatrick C. James 
Published: September 2007

AbstractThe sections in this article areIntroductionOrigin of Particles in the Human EnvironmentEvidence for Size‐dependent Toxicity of ParticlesDissemination and Interferences of Nanoparticles within the BodyEndothelial Cells and Nanoparticle ExposureTesting of Nanoparticle‐induced Effects on Human Endothelial CellsIn VitroMaterials and MethodsCell CultureParticlesTransmission Electron Microscopy (TEM)Cytotoxicity AssayDetection of Ki67 ExpressionQuantification ofIL‐8 Release in Cell Culture SupernatantQuantification ofE‐selectin Cell Surface Protein ExpressionFluorescence StainingStatistical AnalysisResultsDiscussionParticle InternalizationParticle CytotoxicityPro‐inflammatory ActivationConclusions and Consideration of the Risk of Nanoparticles to Human HealthAcknowledgments
Nanomaterials for Environmental Remediation
Authors: Fryxell Glen E. , Mattigod Shas V. 
Published: September 2007

AbstractThe sections in this article areIntroductionNanoparticle‐based Remediation MaterialsAcid–Base ChemistryRedox ChemistryField Deployments ofZVIAbsorption ChemistryHybrid Nanostructured Remediation MaterialsNanostructured Metal PhosphonatesIminodiacetic Acids and Related Chelating LigandsMacrocycle Metal PhosphonatesSelf‐assembled Monolayers on Mesoporous Supports (SAMMS)ThiolSAMMSPerformance with Actual WasteThiolSAMMSPerformance on Contaminated OilAnionSAMMSActinideSAMMSFunctionalCNTsConclusions
Nanoparticles for the Photocatalytic Removal of Endocrine‐disrupting Chemicals in Water
Authors: Coleman Heather M. 
Published: September 2007

AbstractThe sections in this article areIntroductionBackground to Oestrogens in the EnvironmentAdvanced Oxidation Techniques (AOTs)Ultraviolet PhotolysisNanoparticles for Water Treatment ApplicationsTitanium Dioxide PhotocatalysisThe PrincipleTitanium Dioxide Nanoparticles as a PhotocatalystMechanism ofTiO2PhotocatalysisPhotocatalytic Degradation of 17 β‐Oestradiol in Water over an ImmobilizedTiO2CatalystRapid Loss of Oestrogenicity of Natural and Synthetic Oestrogens in Water by Photocatalysis andUVAPhotolysis Monitored using a Yeast Screen BioassayPhotocatalytic Degradation of 17β‐Oestradiol, Oestriol and 17α‐Ethynyloestradiol in a Quartz Coil Reactor Monitored using Fluorescence SpectroscopyComparison of Photocatalysis withUVAandUVCRadiation for the Degradation of Natural and Synthetic Oestrogens in WaterOverall Conclusions and Identification of Research Needs
Nanosensors for Environmental Applications
Authors: Shih Wan Y. , Shih Wei‐Heng 
Published: September 2007

AbstractThe sections in this article areIntroductionOverviewSensorPiezoelectric Cantilever Sensors (PECS)Theory ofPECSUnimorphPECSwith a Nonpiezoelectric ExtensionExamples of DetectionsImmobilization and In‐solution Quantification of Yeast CellsDetection of Binding of Biotinylated Polystyrene Spheres to Immobilized AvidinDetection of Avidin Immobilization at the Cantilever TipSalmonella typhimuriumDetectionNerve Gas Simulant DetectionPiezoelectric Cantilever MiniaturizationPMN‐PT/CuMicrocantileversPZT/SiO2Microcantilevers andPZT/SiO2‐Si3N4NanocantileversConclusionsAcknowledgment
Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment
Authors: Serpe Loredana 
Published: September 2007

AbstractThe sections in this article areIntroductionCancer as Drug Delivery TargetNanoparticles as Anticancer Drug Delivery SystemConventional NanoparticlesSterically Stabilized NanoparticlesActively Targetable NanoparticlesRoutes of Drug Nanoparticles AdministrationAnticancer Drug NanoparticlesAnthracyclinesReverse of P‐glycoprotein Mediated Multidrug Resistance of Cancer Cells to DoxorubicinAntiestrogensAnti‐metabolitesCamptothecinsCisplatinPaclitaxelMiscellaneous AgentsArsenic TrioxideButyric AcidCystatinsDiethylenetriaminepentaacetic AcidMitoxantroneGene Therapy
Nanoparticles for Photodynamic Therapy of Cancer
Authors: Zeisser‐Labouèbe Magali , Vargas Angelica , Delie Florence 
Published: September 2007

Abstract
The sections in this article are

Introduction

Concept and Basis of Photodynamic Therapy and Photodetection

Mechanisms of Photodynamic Therapy and Photodiagnosis

Selective Tumor Uptake of Photosensitizers

Photosensitizers

Conventional Photosensitizers

New Entities

Photodynamic Therapy: Advantages and Limitations

Photosensitizer Formulations

Non‐biodegradable Nanoparticles for Photodynamic Therapy

Metallic Nanoparticles

Ceramic Nanoparticles

Nanoparticles Made of Non‐biodegradable Polymers

Biodegradable Polymeric Nanoparticles for Photodynamic Therapy

Preparation of Biodegradable Polymeric Nanoparticles

In situ
Polymerization

Dispersion of a Preformed Polymer

“Stealth” Particles

Targeted Nanoparticles

In Vitro
Relevance of Polymeric Nanoparticles in
PDT
on Cell Models

Photodynamic Activity of
PS
‐loaded Nanoparticles

Uptake and Trafficking of Photosensitizers

In Vivo
Relevance of Polymeric Nanoparticles in
PDT

Biodistribution and Pharmacokinetics of Photosensitizers Coupled to Nanoparticles

Vascular Effects

In Vivo
Efficacy on Tumor: Tumor Suppression Effects

Adverse Effects

Conclusions

Acknowledgments
Nanovehicles and High Molecular Weight Delivery Agents for Boron Neutron Capture TherapyWe thank Bentham Science Publishers, Ltd for granting copyright release to republish the text and figures of this article.
Authors: Wu Gong , Barth Rolf F. , Yang Weilian , Lee Robert , Tjarks Werner , Backer Marina V. , Backer Joseph M. 
Published: September 2007

AbstractThe sections in this article areIntroductionOverviewGeneral BackgroundGeneral Requirements for Boron Delivery AgentsLow Molecular Weight Delivery AgentsHigh Molecular Weight Boron Delivery AgentsDendrimer‐related Delivery AgentsProperties of DendrimersBoronated Dendrimers Linked to Monoclonal AntibodiesBoron Clusters Directly Linked to mAbAttachment of Boronated Dendrimers tomAbBoronated Dendrimers Delivered by Receptor LigandsEpidermal Growth Factors (EGF)Folate Receptor Targeting AgentsVascular Endothelial Growth Factor (VEGF)Other Boronated DendrimersLiposomes as Boron Delivery AgentsOverview of LiposomesLiposomal Encapsulation of Sodium Borocaptate and BoronophenylalanineBoron Delivery by Non‐targeted LiposomesLiposomal Encapsulation of other Boranes and CarboranesBoron Delivery by Targeted LiposomesImmunoliposomesFolate Receptor‐targeted LiposomesEGFRTargeted LiposomesBoron Delivery by DextransOther Macromolecules used for Delivering Boron CompoundsDelivery of Boron‐containing Macromolecules to Brain TumorsGeneral ConsiderationsDrug‐transport VectorsDirect Intracerebral DeliveryConvection‐enhanced Delivery (CED)Clinical Considerations and ConclusionsAcknowledgments
Dendrimers in Cancer Treatment and Diagnosis
Authors: Sampathkumar Srinivasa‐Gopalan , Yarema Kevin J. 
Published: September 2007

AbstractThe sections in this article areOverviewIntroductionBasic Properties and Applications of DendrimersStructural Features and Chemical and Biological PropertiesBasic Features of Dendritic Macromolecules are Inspired by NatureComparison of the Properties of Dendrimers and Conventional Synthetic PolymersComparison of the Properties of Dendrimers and Proteins (a Biological Polymer)Dendritic Macromolecules Possess a Wealth of Possible ApplicationsMethods for Dendrimer SynthesisHistory and Basic StrategiesCascade Reactions are the Foundation of Dendrimer SynthesisDendrimer Synthesis has Expanded Dramatically in the Past Two DecadesStrategies, Cores, and Building Blocks for Dendritic MacromoleculesDendrimers are Constructed from Simple “Building Blocks”The Synthesis of Dendrimers Follows Either a Divergent or Convergent ApproachHeterogeneously‐functionalized DendrimersBasic Description and Synthetic ConsiderationsGlycosylation is an Example of Surface Modification with Multiple BioactivitiesDendrimers in Drug DeliveryDendrimers are Versatile Nano‐devices for the Delivery of Diverse Classes of DrugsDendritic Drug Delivery: Encapsulation of Guest MoleculesDendrimers have Internal Cavities that can Host Encapsulated Guest MoleculesUsing Dendrimers for Gene DeliveryRelease of Encapsulated “Pro‐drugs”Covalent Conjugation StrategiesDendrimers Overcome many Limitations Inherent in Polymeric Conjugation StrategiesDendrimer Conjugates can be Used as VaccinesRelease of Covalently‐delivered “Pro‐drugs”Fine‐tuning Dendrimer Properties to Facilitate Delivery and Ensure BioactivityDelivery Requires Avoiding Non‐specific Uptake“Local” Considerations: Contact with, and Uptake by, the Target CellDrug Delivery: Ensuring the Biocompatibility of Dendritic Delivery VehiclesBiocompatibility Entails Avoiding “Side Effects” such as Toxicity and ImmunogenicityWater Solubility and ImmunogenicityInherent and Induced ToxicityDendrimers in Cancer Diagnosis and TreatmentDendrimers have Attractive Properties for Cancer TreatmentDendrimer‐sized Particles Passively Accumulate at the Sites of TumorsMultifunctional Dendrimers can Selectively Target Biomarkers found on Cancer CellsMethods for Targeting Specific Biomarkers of CancerTargeting by Folate, a Small Molecule LigandTargeting by Monoclonal AntibodiesDendrimers in Cancer Diagnosis and ImagingLabeled Dendrimers are Important Research Tools for Biodistribution StudiesTowards Clinical Use:MRIImaging AgentsSteps Towards the Clinical Realization of Dendrimer‐based Cancer TherapiesThe Stage is now set for Dendrimer‐based Cancer TherapyBoron Neutron Capture TherapyInnovations Promise to Speed Progress“Mix‐and‐Match” Strategy of Bifunctional Dendritic ClustersTowards Therapeutic Exploitation of Glycosylation Abnormalities found in CancerTowards Targeting Metabolically‐engineered Carbohydrate EpitopesConcluding RemarksAcknowledgments
Nanoparticles for Optical Imaging of Cancer
Authors: Santra Swadeshmukul , Dutta Debamitra 
Published: September 2007

AbstractThe sections in this article areIntroductionCancer Imaging TechniquesComputed Tomography (CT) ScanningMagnetic Resonance (MR)Positron Emission Tomography (PET)Single‐photon EmissionCT(SPECT)Ultrasonography (US)Optical ImagingBasics of Optical ImagingOptical Imaging TechniquesOptical Contrast AgentsNanoparticles for Optical ImagingWhy Nanoparticles for Optical Imaging?Development of Nanoparticle‐based Contrast AgentsQuantum DotsGold NanoparticlesDye‐doped Silica NanoparticlesOptical Imaging of Cancer with NanoparticlesActive TargetingPassive TargetingCancer Imaging with Quantum DotsCancer Imaging with Gold NanoparticlesCancer Imaging with Dye‐doped Silica NanoparticlesOther Nanoparticle‐based Optical Contrast AgentsConclusions and PerspectivesAcknowledgments
Nanogold in Cancer Therapy and Diagnosis
Authors: Mukherjee Priyabrata , Bhattacharya Resham , Patra Chitta Ranjan , Mukhopadhyay Debabrata 
Published: September 2007

AbstractThe sections in this article areIntroductionMedicinal use of Gold: A Historical PerspectiveApplication of Gold Nanoparticles in CancerAngiogenesis and CancerAgents that Inhibit Endothelial Proliferation or ResponseAgents that Block Activation of AngiogenesisAgents that Block Extracellular Matrix BreakdownUnique Anti‐angiogenic Properties of Gold NanoparticlesGold Nanoparticles InactivateVEGF165What is the Mechanism of Action?Effect of Gold Nanoparticles on the Activity ofVEGF165,VEGF121,bFGFandEGFEffect of Gold Nanoparticles on Signaling Events ofVEGF165Effect of Nanogold on Downstream Signaling events ofVEGF165Effect of Gold Nanoparticles on Migration ofHUVECCellsEffect of Gold Nanoparticles on Angiogenesisin vivoGold Radioisotopes in Cancer TreatmentApplication of Gold Conjugates in the Treatment of CancerGold–TNFConjugate in Cancer Therapeutics“2 in 1” System in Cancer TherapeuticsBiocompatibility of Gold NanoparticlesCellular Adhesion EffectsLocal Biological EffectsSystemic and Remote EffectsEffects of the Host on the ImplantAddressing the Biocompatibility of Gold Nanoparticles usingDNAMicroarray AnalysisInternalization of Gold Nanoparticles byHUVECsNanogold Particles do not Alter Global Pattern of Transcription byHUVECCells under Serum‐free ConditionsNanogold Particles do not Alter the Global Pattern of Transcription byHUVECsin Near‐normal Culture ConditionsSynthetic Approaches to Gold NanoparticlesChemical MethodsPhysical MethodsBiological MethodsNanotechnology in Detection and Diagnosis with Gold NanoparticlesCancer DetectionDetection inDNASingle‐mismatch Detection inDNAFuture DirectionAcknowledgments