bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative study of an intervention for depression among patients with diabetes: how can we optimize patient—professional interaction?
Authors: Gask Linda , Ludman Evette , Schaefer Judith 
Published: June 2007

Objectives: To describe the communication between the depression care specialist (DCS) nurses and patients with both depression and diabetes in an intervention study. Our aims were to inform both the quantitative findings of the present trial and the design of future primary care intervention studies. Methods: Qualitative content analysis of consultations between DCS nurses and patients in nine primary care clinics. Results: Patients experienced a wide range of physical, social and psychological problems. The DCS nurses employed a range of interventions in addition to the problem-solving and case-management skills that formed the basis of this intervention. Conclusions: Patients sometimes posed difficulties in being unable to understand the treatment, unprepared to engage with a new treatment and unready (or even unable) to acquire new skills. To optimize the interaction between patient and professional in the case management of depression and diabetes, training should provide guidance in the use of different models of care (medical and psychological), help case managers to identify and negotiate problem scenarios and combine an active model of therapy such as problem-solving treatment for primary care (PST-PC) with elements from motivational interviewing, ensure effective engagement in treatment, and specifically explore how interaction between depression and diabetes might result in adverse outcomes.
Health Care, Jesus and the Church
Authors: Gill Robin 
Published: June 2007

AbstractThis article seeks to identify distinctively Christian values that the Church might bring to public discussions of health care today. It does this by looking carefully at the Synoptic healing stories, identifying in the process four dominant virtues: compassion, care, faith and humility. It argues that together these virtues form an ideal typology that can be used to complement, deepen and sometimes challenge, but not simply replace, the prevalent values current within much health-care ethics today.
The Coming of Lutheran Ministries to America
Authors: Erling Maria 
Published: June 2007

AbstractThis article examines the historical and theological foundations of Lutheran doctrines of the ministry of word and sacrament in the Reformation and the Confessional documents and how this inheritance was transposed to the American context. Against this background, it considers the debates on ministerial issues that surrounded the founding of the Evangelical Lutheran Church in America and the challenges with regard to ministry and mission that face Lutherans in America today as a result of fresh immigration and tensions between the local and the wider church.
TGF-β combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors
Authors: Li Geling , Abediankenari Saeid , Kim Young-June , Campbell Timothy B. , Ito Shigeki , Graham-Evans Barbara , Cooper Scott , Broxmeyer Hal E. 
Published: June 2007

AbstractTolerogenic dendritic cells (DCs) may be valuable in transplantation for silencing immune reaction. Macrophage colony-stimulating factor (M-CSF)/IL-4 induces differentiation of cord blood (CB) monocytes into DCs (M-DCs) with tolerogenic phenotype/function. We assessed whether factors produced by tolerogenic DCs could modulate hematopoiesis. TGF-β1 added to CB M-DC cultures induced bona fide DC morphology (TGF-M-DCs), similar to that of DCs generated with TGF-β and granulocyte-macrophage colony-stimulating factor (GM-CSF)/IL-4 (TGF-GM-DCs). Of conditioned media (CM) produced from TGF-M-DCs, TGF-GM-DCs, M-DCs, and GM-DCs, TGF-M-DC CM was the only one that enhanced SCF, Flt3 ligand, and TPO expansion of myeloid progenitor cells ex vivo. This effect was blocked by neutralizing anti–M-CSF Ab, but protein analysis of CM suggested that M-CSF alone was not manifesting enhanced expansion of myeloid progenitors. LPS-stimulated TGF-M-DCs induced T-cell tolerance/anergy as effectively as M-DCs. TGF-M-DCs secreted significantly lower concentrations of progenitor cell inhibitory cytokines and were less potent in activating T cells than TGF-GM-DCs. Functional differences between TGF-M-DCs and TGF-GM-DCs included enhanced responses to LPS-induced ERK, JNK, and P38 activation in TGF-M-DCs and their immune suppressive–skewed cytokine release profiles. TGF-M-DCs appear unique among culture-generated DCs in their capability for silencing immunity while promoting expansion of myeloid progenitors, events that may be of therapeutic value.
Rehabilitation of Severely Atrophied Mandible Using Free Iliac Crest Bone Grafts and Dental Implants: Report of Two Cases
Authors: Güven Orhan 
Published: June 2007

Abstract
The purpose of this study was to reveal the improvement in facial esthetics and maintenance of mastication in severely atrophied mandibles with inadequate alveolar ridges in 2 patients. Bone graft harvested from iliac crest was used for the reconstruction in the first case, followed by the application of 2 dental implants after 6 months. A free iliac bone graft and 2 dental implants were also used simultaneously with a 1-stage surgery in the second case; the patient had previously had a mandibular reconstruction with a rib graft. Both of the patients achieved remarkably functional and esthetic improvements after treatment. Free iliac bone graft is considered to be a favorable alternative for the maintenance of satisfactory functional and esthetic results in patients with severely atrophied alveolar ridges.
Rotary Suspension Culture Enhances the Efficiency, Yield, and Homogeneity of Embryoid Body Differentiation
Authors: Carpenedo Richard L. , Sargent Carolyn Y. , McDevitt Todd C. 
Published: June 2007

Abstract
Embryonic stem (ES) cells hold great promise as a robust cell source for cell-based therapies and as a model of early embryonic development. Current experimental methods for differentiation of ES cells via embryoid body (EB) formation are either inherently incapable of larger-scale production or exhibit limited control over cell aggregation during EB formation and subsequent EB agglomeration. This report describes and characterizes a novel method for formation of EBs using rotary orbital motion that simultaneously addresses both concerns. EBs formed under rotary suspension conditions were compared with hanging-drop and static EBs for efficiency of EB formation, cell and EB yield, homogeneity of EB size and shape, and gene expression. A 20-fold enhancement in the number of cells incorporated into primitive EBs in rotary versus static conditions was detected after the first 12 hours, and a fourfold increase in total cell yield was achieved by rotary culture after 7 days. Morphometric analysis of EBs demonstrated formation and maintenance of a more uniform EB population under rotary conditions compared with hanging-drop and static conditions. Quantitative gene expression analysis indicated that rotary EBs differentiated normally, on the basis of expression of ectoderm, endoderm, and mesoderm markers. Increased levels of endoderm gene expression, along with cystic EB formation, indicated by histological examination, suggested that differentiation was accelerated in rotary EBs. Thus, the rotary suspension culture method can produce a highly uniform population of efficiently differentiating EBs in large quantities in a manner that can be easily implemented by basic research laboratories conducting ES cell differentiation studies.
Disclosure of potential conflicts of interest is found at the end of this article.
The Extent to Which Critical Thinking Is Subject-Specific: Further Clarification
Authors: Ennis Robert H. 
Published: June 2007

In this response to McPeck’s reply to my paper, I briefly summarize my earlier essay, and make four major points: (a) that the vagueness of the concepts, domain, field, and subject, is a problem when subject specificity serves as a basis for prediction, though not necessarily when it serves as a slogan or a vague warning; (b) that the distinction between the subject matter of schools and the subject matter of everyday life is a viable one, though not the mutually exclusive one that McPeck seems to attribute to me; (c) that the distinction between topic and school subject serves to help avoid a tempting equivocation that starts with the premise that all thinking is about some subject; and (d) that “relatively narrow” general thinking abilities can be very broad in the range of their application, and that many, though perhaps obvious at times to some, are not trivial, because numerous people seem not to employ them in important situations. An underlying concern is McPeck’s apparent assumption that showing something (e.g., subject-matter knowledge) to be a necessary condition for critical thinking establishes that it is essentially a sufficient condition, or at least that all other things (e.g., general abilities) are unimportant. There is yet much research to be done before the basic issues can be resolved; I hope that this conceptual clarification will facilitate this research.
Introduction to a Special Issue of the Journal of Educational and Behavioral Statistics on Value-Added Assessment
Authors: Wainer Howard 
Published: June 2007

“Some professors are justly renowned for their bravura performances as Grand Expositor on the podium, Agent Provocateur in the preceptorial, or Kindly Old Mentor in the corridors. These familiar roles in the standard faculty repertoire, however, should not be mistaken for teaching, except as they are validated by the transformation of the minds and persons of the intended audience.” “Good teachers evaluate themselves with a pitiless gaze and measure their successes not by their virtuosity as performers but by their contribution to the transformation of students.” ( Bressler, 1991 )
Total Syntheses in Solution of TOAC‐Labelled Alamethicin F50/5 Analogues
Authors: Peggion Cristina , Jost Micha , Baldini Chiara , Formaggio Fernando , Toniolo Claudio 
Published: June 2007

AbstractTotal syntheses in solution of a set of four selected analogues of the 19‐mer component F50/5 of alamethicin, the most extensively studied among the channel‐former peptaibol antibiotics, are planned and reported. All analogues bear three Glu(OMe) residues, replacing the Gln residues at positions 7, 18, and 19 of the naturally occurring compound. Three analogues are mono‐labelled with the free‐radical‐containing amino acid residue TOAC at the strategic positions 1, 8, or 16. The fourth analogue is bis‐labelled with the same EPR‐active residue at both positions 1 and 16. In the native sequence, all of the positions where TOAC replacements have been introduced are characterized by residues of Aib, the prototype of the class of helicogenic Cα‐tetrasubstituted α‐amino acids. All of the TOAC analogues synthesized exhibit significant membrane‐modifying properties.
Solvent Dependence of the Rotational Diffusion of TOAC‐Spin‐Labeled Alamethicin
Authors: Marsh Derek , Jost Micha , Peggion Cristina , Toniolo Claudio 
Published: June 2007

AbstractThree derivatives of the hydrophobic, channel‐forming peptaibiotic alamethicin (F50/5) have been synthesized, the original Aib residue at position 1, 8, or 16 being replaced with the spin‐labeled amino acid TOAC (=2,2,6,6‐tetramethylpiperidin‐1‐oxyl‐4‐amino‐4‐carboxylic acid). Electron‐paramagnetic‐resonance (EPR) spectroscopy was used to characterize the rotational diffusion of these compounds in five isotropic solvents of differing viscosity and polarity, including MeOH, EtOH, PrOH, i‐PrOH, and hexanol (HxOH). In MeOH, the labeled alamethicins were found to rotate anisotropically as a monomer (axial ratio a/b=3). In aliphatic alcohols of increasing viscosity (and hydrophobicity), the rotational correlation times progressively increased. Even in HxOH, the (fivefold) increase in correlation time was no greater than the increase in viscosity. We conclude that TOAC‐labeled alamethicins remain monomeric in these solvents of relatively high polarity.
Dual‐modality in vivo monitoring of subventricular zone stem cell migration and metabolism
Authors: Cicchetti Francesca , Gross Robert E. , Bulte Jeff W.M. , Owen Mary , Chen Iris , Saint‐Pierre Martine , Wang Xukui , Yu Meixiang , Brownell Anna‐Liisa 
Published: June 2007

AbstractRat subventricular zone (SVZ) stem cells were labeled with superparamagnetic iron oxide particles (SPIO) to follow their fate and migratory potential with magnetic resonance imaging (MRI) and positron emission tomography (PET). Labeled cells were transplanted into either the right rostral migratory stream (RMS) or striatum of normal adult Sprague–Dawley rats and serially followed for 3 months. Minimal migration of the cells implanted into the striatum was observed after 3 weeks whereas SVZ cells implanted into the RMS migrated toward the olfactory bulb at 1 week post‐transplantation. PET studies of glucose metabolism using 18F‐FDG demonstrated enhanced glucose utilization in the striatum of transplanted animals. PET studies conducted 3 months after transplantation showed elevated accumulation of 11C‐raclopride (dopamine receptor type 2) and 11C‐CFT (dopamine transporter) binding in the striatal grafts. Implanted SVZ cells did not induce significant inflammation as identified by PET using 11C‐PK11195, a ligand detecting activated microglia. Histological analysis identified viable SPIO‐labeled cells (some of which were nestin‐positive) 7 weeks post‐transplantation, suggesting a prolonged presence of undifferentiated neural stem cells within transplants. In addition, double immunostaining for neuronal and astrocytic markers (NeuN and GFAP) indicated that differentiation into neuronal and astrocytic phenotypes also occurred. Thus, combining MRI and PET enables monitoring of cell migration and metabolism non‐invasively in vivo for extended periods of time. Copyright © 2007 John Wiley & Sons, Ltd.
Agglomeration of NTO on the surface of HMX particles in water‐NMP solvent
Authors: Kim Kwang‐Joo , Kim Hyoun‐Soo 
Published: June 2007

AbstractA sensitive explosive was coated with a less sensitive explosive in order to improve stability while maintaining explosion performance. Agglomeration of 3‐nitro‐1,2,4‐triazole‐5‐one (NTO) on the surface of cyclotetramethylene tetranitramine (HMX) crystals in water‐N ‐methyl‐2‐pyrrolidone (NMP) solvent was performed by cooling crystallization. Phenomena for coating by crystallization and agglomeration were studied by in‐situ measurement. The agglomeration kinetic for the coating of NTO on HMX crystals was correlated with the 3rd power of the solution supersaturation and the 2nd power of the number of the suspended particles. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Fatty acid profiles of 80 vegetable oils with regard to their nutritional potential
Authors: Dubois Virginie , Breton Sylvie , Linder Michel , Fanni Jacques , Parmentier Michel 
Published: June 2007

AbstractThe current concern for fat intake in western countries has raised the question of the individual fatty acid (FA) impact on health. This important issue has strengthened the awareness of nutritionists and food manufacturers for the control of the FA profile of food products. The aim of this review is to provide a classification of the FA profiles of 80 vegetable oil sources, according to their nutritional potential. The first part of the review focuses on lipoprotein metabolism, and on the impact of each dietary FA on blood lipid composition (LDL‐cholesterol, HDL‐cholesterol and circulating triacylglycerols). In the second part of the review, the oil sources are clustered by similar FA profiles, and the classification is discussed with regard to the individual FA action on blood lipid composition. Apart from the major vegetable seeds, the clustering highlighted some interesting nutritional oil sources containing mainly α‐linolenic acid (camelina, linseed, perilla and stock oils), or interesting amounts of the two essential FA (purslane, chia, raspberry seed, sea buckthorn seed and salicorn oils). Furthermore, this classification provides a useful tool for the formulation of the FA profile of food products.
Geometrical isomerization of polyunsaturated fatty acids in physically refined rapeseed oil during plant‐scale deodorization
Authors: Čmolík Jiří , Pokorný Jan , Doležal Marek , Svoboda Zdeněk 
Published: June 2007

AbstractThe effect of the operating temperature (between 220 and 270 °C) on the formation of trans isomers of linoleic and linolenic acids in physically refined rapeseed oil during deodorization in a plant‐scale semicontinuous tray‐type deodorizer (capacity 10 t/h) was investigated. The industrial procedures of physical refining consisted of a two‐step bleaching and deodorization process. The degree of isomerization of linoleic acid ranged from 0.33 to 4.77% and that of linolenic acid from 4.43 to 45.22% between 220 and 270 °C, respectively. A relation between the logarithm of the degree of isomerization and the deodorization temperature can be approximated by statistically highly significant linear functions for both linoleic and linolenic acids. Oleic acid was resistant to the heat‐induced geometrical isomerization. The values found for the ratio between the degrees of isomerization of linolenic and linoleic acids, slightly decreasing with increasing temperature, were equal to 13.6 and 12.9 at 230 and 240 °C, respectively. Two trans isomers of linoleic acid, exclusively with one double bond isomerized into trans configuration, and four trans isomers of linolenic acid, mostly with one double bond isomerized into trans configuration, were determined in deodorized rapeseed oils. Linolenic acid was observed to be the main source responsible for the formation of nearly all trans fatty acids in physically refined rapeseed oil. At 235 °C, a deodorization temperature considered as a reasonable technological compromise, the content of trans fatty acids in plant‐scale physically refined rapeseed oil was less than 1% of total fatty acids, which would be acceptable for further application.
A holistic approach of access to higher education
Authors: Larrance Anneke J. 
Published: June 2007

AbstractThe Associated Colleges of the St. Lawrence Valley's Liberty Partnerships Program provides tutoring, referrals, educational support, advocacy, counseling, social activities, and health and wellness information, as well as supports parental involvement in a holistic approach of access to higher education that serves secondary students in an economically poor rural region of northern New York.
Four New Lariciresinol‐Based Lignan Glycosides from the Roots of Rhus javanica var. roxburghiana
Authors: Ouyang Ming‐An , Wein Yung‐Shung , Kuo Yueh‐Hsiung 
Published: June 2007

AbstractThe four new lariciresinol‐based lignan glycosides, (−)‐lariciresinol 4′‐(6″‐O‐feruloyl‐β‐D‐glucopyranoside) (1), (−)‐lariciresinol 4′‐(4″,6″‐di‐O‐feruloyl‐β‐D‐glucopyranoside) (2), 5,5′‐dimethoxylariciresinol 4′‐(4″,6″‐di‐O‐feruloyl)‐β‐D‐glucopyranoside) (3), and 4‐O‐[α‐(1,2‐dihydroxyethyl)syringyl]‐5,5′‐dimethoxylariciresinol 4′‐(4″,6″‐di‐O‐feruloyl‐β‐D‐glucopyranoside) (4), together with two known ones, lariciresinol 4′‐β‐D‐glucopyranoside) (5) and tortoside B (6), were isolated from the BuOH extract of Rhus javanica var. roxburghiana roots, and their structures were established by means of various spectroscopic techniques.
Biotransformation of p‐Coumaric Acid (=(2E)‐3‐(4‐Hydroxyphenyl)prop‐2‐enoic Acid) by Momordica charantia Peroxidase
Authors: Liu Hai‐Li , Huang Xue‐Feng , Wan Xiang , Kong Ling‐Yi 
Published: June 2007

AbstractLC/MS3‐Guided biotransformation of p‐coumaric acid (=(2E)‐3‐(4‐hydroxyphenyl)prop‐2‐enoic acid; CA) with H2O2/Momordica charantia peroxidase at pH 5.0 and 45° in the presence of acetone has resulted in the isolation of three CA trimers, triCA1 (1), triCA2 (trans‐2), and triCA3 (cis‐2), and seven CA dimers, diCA1–diCA7, i.e., 3–9, among which seven (triCA1–triCA3 and diCA1–diCA4) are new compounds and three (diCA5–diCA7) are known compounds. The structures were established by 2D‐NMR such as HSQC, HMBC, and NOESY measurements. The possible mechanism for the formation of the products is also discussed (Schemes 1–3). This is the first time that the biotansformation of p‐coumaric acid catalyzed by peroxidase in vitro was achieved. Compounds triCA3 (cis‐2), diCA1 (3), diCA5 (7), and diCA7 (9) exhibit a stronger antioxidative activity than the parent CA.
PIK3CAmutation is predictive of poor survival in patients with colorectal cancer
Authors: Kato Shunsuke , Iida Satoru , Higuchi Tetsuro , Ishikawa Toshiaki , Takagi Yoko , Yasuno Masamichi , Enomoto Masayuki , Uetake Hiroyuki , Sugihara Kenichi 
Published: June 2007

AbstractThe PI3K‐AKT pathway is activated in a variety of human cancers, resulting in disturbance of cell growth, proliferation and survival. Among the factors affecting the pathway, theK‐Rasmutation andPIK3CAmutation are the most common oncogenic alterations in colorectal cancer. We hypothesized that these two mutations are important in activation of the PI3K pathway and colorectal carcinogenesis. In this study, we aimed to examine the influence ofPIK3CAmutation andK‐Rasmutation on AKT activation, and to clarify whetherPIK3CAmutation,K‐Rasmutation and p‐AKT expression may be used as parameters for predicting prognosis in colorectal cancer. Tissue samples from 158 colorectal cancer patients who underwent surgical resection were examined. The sequences of exon 1 ofK‐Rasand exons 9 and 20 ofPIK3CAwere determined by direct sequencing using genomic DNA extracted from paraffin‐embedded blocks. Activation status of AKT was evaluated by immunohistochemical staining using phospho‐specific AKT antibody (Ser473). Correlation between these factors and clinicopathologic findings/patient survival were examined. As a result,PIK3CAmutation was significantly associated with shorter relapse‐free survival (RFS) in stage II/III patients (p= 0.0216) and shorter disease‐specific survival in all patients (p= 0.0357). In the multivariate analysis,PIK3CAmutation was the only independent and significant prognostic factor for RFS in stage II/III patients (p= 0.0433, HR 2.478). This study revealed the prognostic value ofPIK3CAmutation in colorectal cancer patients. Patients withPIK3CAmutation should be followed up carefully. Moreover, our result suggests that inhibition ofPIK3CAmutant may be a new molecular target therapy. © 2007 Wiley‐Liss, Inc.