bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern Internet Search Analytics: Is There a Difference in What Patients are Searching Regarding the Operative and Nonoperative Management of Scoliosis?
Authors: Mastrokostas Paul G. , Mastrokostas Leonidas E. , Emara Ahmed K. , Wellington Ian J. , Ginalis Elizabeth , Houten John K. , Khalsa Amrit S. , Saleh Ahmed , Razi Afshin E. , Ng Mitchell K. 
Published: April 2024

Study Design Observational Study. Objectives This study aimed to investigate the most searched types of questions and online resources implicated in the operative and nonoperative management of scoliosis. Methods Six terms related to operative and nonoperative scoliosis treatment were searched on Google’s People Also Ask section on October 12, 2023. The Rothwell classification was used to sort questions into fact, policy, or value categories, and associated websites were classified by type. Fischer’s exact tests compared question type and websites encountered between operative and nonoperative questions. Statistical significance was set at the .05 level. Results The most common questions concerning operative and nonoperative management were fact (53.4%) and value (35.5%) questions, respectively. The most common subcategory pertaining to operative and nonoperative questions were specific activities/restrictions (21.7%) and evaluation of treatment (33.3%), respectively. Questions on indications/management (13.2% vs 31.2%, P < .001) and evaluation of treatment (10.1% vs 33.3%, P < .001) were associated with nonoperative scoliosis management. Medical practice websites were the most common website to which questions concerning operative (31.9%) and nonoperative (51.4%) management were directed to. Operative questions were more likely to be directed to academic websites (21.7% vs 10.0%, P = .037) and less likely to be directed to medical practice websites (31.9% vs 51.4%, P = .007) than nonoperative questions. Conclusions During scoliosis consultations, spine surgeons should emphasize the postoperative recovery process and efficacy of conservative treatment modalities for the operative and nonoperative management of scoliosis, respectively. Future research should assess the impact of website encounters on patients’ decision-making.
Improving Adherence to the Target Window for Cabotegravir + Rilpivirine Long-Acting Injections Through the CHORUS™ App and Web Portal: A Cluster Randomized Trial
Authors: Wohlfeiler Michael B. , Brunet Laurence , Cochran Quateka , Fusco Jennifer S. , Hsu Ricky K. , Fusco Gregory P. 
Published: April 2024

Background We evaluated the impact of the CHORUS™ app on adherence to the cabotegravir and rilpivirine long-acting injectable (CAB + RPV LAI) monthly injections schedule. Methods Healthcare centers (HCCs) were randomized to access CHORUS™ CAB + RPV LAI features (intervention) or not (control) from 01OCT2021-31JAN2022. Target window adherence (maintenance injections ≤7 days before/after target day) was assessed with multivariate logistic regression (generalized estimating equations). Results CAB + RPV LAI was administered to 188 and 79 individuals at intervention and control HCCs, respectively. Intervention was not associated with improved target window adherence (adjusted odds ratio: 0.61 [95% CI: 0.30-1.25]). However, app use was associated with increased odds of adherence compared to no app use among all intervention HCCs (2.98 [1.26-7.06]) and at smaller HCCs (3.58 [1.31-9.80]). Conclusions While access to CHORUS™ CAB + RPV LAI features did not improve target window adherence, app use did, especially at smaller HCCs which may not have established LAI management procedures. Trial registration https://clinicaltrials.gov/show/NCT04863261.
Avoiding relapses after crises: Exploring the influence of firm investors’ characteristics on organizational resilience
Authors: Mellado-Garcia Elena , Ortiz-de-Mandojana Natalia , Aragon-Correa Juan Alberto 
Published: April 2024

Many firms may successfully navigate an organizational crisis, but may find themselves entangled in another soon after. Building on a resource-dependence perspective, this study evaluates how certain investor characteristics foster organizational resilience during a crisis by preventing a relapse following recovery. Drawing on data from 2014 to 2019, we analyzed 359 firms that faced a crisis in 2015, as indicated by their Altman Z-score values. Our findings reveal that diversity and patience of investors prevent firms from relapsing into upcoming crises; however, the probability of relapse increases when concentrated investors boost the firm’s capital during the in-crisis period. We bridge the gap between the resource-dependence theory and literature on organizational resilience and contribute by extending previous analyses on the relevance of investors to recover from a crisis to identify how in-crisis investors’ features also state the foundations to avoid future relapses.JEL CLASSIFICATION: D74; D81; G01; G32; P45
Turkish adaptation and verification of the incident-reporting attitude scale used for staff in long-term care facilities
Authors: Yılmaz Ayşegül , Yıldız Keskin Ayşe , Duygulu Sergül , Yeşildal Müjdat 
Published: April 2024

Background Determining nurses’ attitudes and behaviors toward error reporting is important in providing safe, high-quality patient care. The current study aimed to test Turkish validity and reliability of the Incident-Reporting Attitude Scale for Staff in Long-Term Care Facilities. Methods This psychometric study was conducted in two stages with 395 nurses and nurse managers in long-term care at a university hospital between May 2021 and January 2022. First, the Turkish adaptation of the scale was performed. The scale's internal consistency was evaluated using Cronbach's alpha and corrected item-total score correlation. Content validity indices were used for content validity, and exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used for construct validity. Discriminant analysis and internal consistency coefficient were used for reliability analyses. Results The results showed that the Turkish scale adaptation is adequate for language and content equivalence. According to CFA, the scale comprising 31 items and two subscales in the original version showed a significantly good fit in a 26-item and five-factor model. The Cronbach's alpha of the modified scale was 0.92; it was 0.88, 0.94, 0.82, 0.96, and 0.90 for the subscales, respectively. Conclusions The Turkish scale adaptation has consistently shown acceptable psychometric reliability and validity characteristics. It can be used by healthcare services and nursing managers to evaluate nurses’ attitudes toward incident reporting in healthcare facilities providing long-term care.
The Evolution of Mindfulness-Based Stress Reduction Teacher Training Programs for People Who Serve Historically Underrepresented Racial and Ethnic Groups
Authors: Dejene Abraham , Carter Zoie , Woo Erin , Sun Shufang , Loucks Eric B. , Proulx Jeffrey 
Published: April 2024

Background There is a lack of mindfulness instructors from underserved/underrepresented communities who have completed systematic mindfulness teacher-training programs to meet the growing demand for culturally responsive mindfulness training in those communities. Objectives To investigate strategies for increasing the representation of Mindfulness-Based Stress Reduction (MBSR) teachers who serve historically underrepresented racial and ethnic groups. Methods Conducted through 4 one-hour Zoom focus groups (n = 54; women = 74%), this study queried individuals with experience serving underrepresented racial and ethnic communities, and had mindfulness experience, on how to increase participation from underrepresented communities in mindfulness. Thematic analysis of transcripts of participant responses involved double-coding by three team members, supporting rigorous evaluation of the data. All respondents who expressed interest in participating enrolled (no dropout from study enrollment to participation in focus groups). Results The study identified four key themes that illuminate challenges and essential adaptations for MBSR teacher training aimed at individuals serving historically underrepresented racial and ethnic groups. These themes include: (1) Cost and time commitment; (2) Trauma sensitivity; (3) Cultural Awareness; and (4) Diversity in teachers. Conclusion Participants provided actionable recommendations poised to facilitate the expansion of MBSR into more diverse communities, emphasizing optimal benefits and effective communication of inherent healing strengths within these communities. The findings underscore the compelling interest among leaders in marginalized communities to extend the reach of MBSR through culturally responsive approaches. This involves guiding pertinent adjustments and encouraging greater involvement of underserved communities in MBSR teacher training programs.
Geomorphic changes after the 2021 Central European flood in the Ahr Valley by LiDAR-based differences
Authors: Steinritz Vanessa , Bellanova Piero , Schmidt Bernd , Schüttrumpf Holger , Schwarzbauer Jan , Reicherter Klaus 
Published: April 2024

Abstract
Background
In July 2021, destructive floods in Western Europe were triggered by enormous precipitation rates related to a low-pressure system named "Bernd." These catastrophic events led not only to major damage to infrastructure, severe economic losses, and the loss of lives but also to significant landscape changes and modifications. Here, we focus, as a case study, on the flood aftermath of the Ahr Valley in Rhineland-Palatinate state in western Germany, as it was one of the most affected and destroyed regions by the flood. We utilize high-resolution Digital Terrain Models (DTMs) based on airborne Light Detection and Ranging (LiDAR) that were taken shortly before and after the flood to investigate insights into geomorphic changes.

Results
By calculating Digital Terrain Models of Difference (DoD), we are able to quantify volumetric and areal changes caused by erosional and depositional processes for different sites in the Ahr Valley. Due to the morphology of the narrow Ahr Valley, most of the erosion and deposition is located within the deeply incised canyon of the Ahr River. The comprehensive analysis reveals notable morphological modifications throughout the study area, with a calculated erosion/deposition areal ratio of 0.46 and an erosion/deposition volumetric ratio of 0.63. Our findings indicate massive deposition regarding both areal and volumetric. We selected six different locations along the Ahr Valley that showcase distinct aspects of flood-induced fluvial morpho-dynamics. Deposition occurred mainly in point bars and downstream of destroyed artificial levees, in a braided river style.

Conclusion
Our investigations contribute to an overview and assessment of the morphological response to the destructive flood in the Ahr Valley. The results emphasize the necessity for implementing effective flood management strategies, as most of the urban areas in the Ahr Valley were flooded. Moreover, our results provide valuable insights into the impacted areas, highlighting vulnerable locations for flood-related erosion and deposition. This information could contribute to future mitigation and protection efforts, aiding in the development of comprehensive strategies to minimize the impact of similar events in the future.
Genomic insights into local adaptation and vulnerability of Quercus longinux to climate change
Authors: Sun Pei-Wei , Chang Jui-Tse , Luo Min-Xin , Liao Pei-Chun 
Published: April 2024

AbstractBackgroundClimate change is expected to alter the factors that drive changes in adaptive variation. This is especially true for species with long life spans and limited dispersal capabilities. Rapid climate changes may disrupt the migration of beneficial genetic variations, making it challenging for them to keep up with changing environments. Understanding adaptive genetic variations in tree species is crucial for conservation and effective forest management. Our study used landscape genomic analyses and phenotypic traits from a thorough sampling across the entire range ofQuercus longinux, an oak species native to Taiwan, to investigate the signals of adaptation within this species.ResultsUsing ecological data, phenotypic traits, and 1,933 single-nucleotide polymorphisms (SNPs) from 205 individuals, we classified three genetic groups, which were also phenotypically and ecologically divergent. Thirty-five genes related to drought and freeze resistance displayed signatures of natural selection. The adaptive variation was driven by diverse environmental pressures such as low spring precipitation, low annual temperature, and soil grid sizes. Using linear-regression-based methods, we identified isolation by environment (IBE) as the optimal model for adaptive SNPs. Redundancy analysis (RDA) further revealed a substantial joint influence of demography, geology, and environments, suggesting a covariation between environmental gradients and colonization history. Lastly, we utilized adaptive signals to estimate the genetic offset for each individual under diverse climate change scenarios. The required genetic changes and migration distance are larger in severe climates. Our prediction also reveals potential threats to edge populations in northern and southeastern Taiwan due to escalating temperatures and precipitation reallocation.ConclusionsWe demonstrate the intricate influence of ecological heterogeneity on genetic and phenotypic adaptation of an oak species. The adaptation is also driven by some rarely studied environmental factors, including wind speed and soil features. Furthermore, the genetic offset analysis predicted that the edge populations ofQ. longinuxin lower elevations might face higher risks of local extinctions under climate change.
The responses of pepper plants to nitrogen form and dissolved oxygen concentration of nutrient solution in hydroponics
Authors: Roosta Hamid Reza 
Published: April 2024

Abstract
Background
The presence of oxygen in the growth medium is absolutely essential for root development and the overall metabolic processes of plants. When plants do not have an adequate oxygen supply for respiration, they can experience a condition known as hypoxia. In order to investigate the impact of different nitrogen forms and varying oxygen levels in nutrient solutions on the growth, photosynthesis, and chlorophyll fluorescence parameters of bell pepper plants, a comprehensive study was conducted. The experiment was designed as a factorial experiment, considering two main factors: nitrogen forms (calcium nitrate and ammonium sulfate) with a fixed nitrogen concentration of 5 mM, and the oxygen levels of the nutrient solutions (ranging from 1.8 ± 0.2 to 5.3 ± 0.2 mg. L-1).

Results
The study examined the effects of nitrogen (NH4+ and NO3−) application on various parameters of vegetative growth. The results demonstrated that the use of ammonium (NH4+) led to a reduction in the most measured parameters, including the fresh and dry mass of both the root and shoot, at low O2 concentrations of 1.8 ± 0.2; 2.6 ± 0.2 and 3.8 ± 0.2 mg. L-1. However, an interesting observation was made regarding the impact of oxygen levels on root growth in plants grown with nitrate (NO3−). Specifically, the highest levels of oxygen significantly increased root growth in NO3−-fed plants. Additionally, the application of NH4+ resulted in an increase in chlorophyll concentration in the leaves, particularly when combined with high oxygen levels in the nutrient solution. On the other hand, leaves of plants fed with NO3− exhibited higher photosynthetic rate (A), intrinsic water use efficiency (iWUE), and instantaneous carboxylation efficiency (A/Ci) compared to those fed with NH4+. Furthermore, it was found that NO3−-fed plants displayed the highest instantaneous carboxylation efficiency at oxygen levels of 3.8 and 5.3 mg. L-1, while the lowest efficiency was observed at oxygen levels of 1.8 and 2.6 mg. L-1. In contrast, NH4+-grown plants exhibited a higher maximal quantum yield of PSII photochemistry (Fv/Fm), as well as increased variable fluorescence (Fv) and maximum fluorescence (Fm), compared to NO3−-grown plants. Interestingly, the NO3−-fed plants showed an increase in Fv/Fm, Fv, and Fm with the elevation of oxygen concentration in the nutrient solution up to 5.3 mg. L-1.

Conclusion
This study showed that, the growth and photosynthesis parameters in bell pepper plants are sensitive to oxygen stress in floating hydroponic culture. Therefore, the oxygen level in the nutrient solution must not be lower than 3.8 and 5.3 mg. L-1 in NH4+ and NO3− –supplied culture media or nutrient solutions, respectively.
Do emergency medical dispatchers choose the same response to serious injury in men and women – a qualitative study
Authors: Mellum Marlene , Saei Raika , Brattebø Guttorm , Wisborg Torben 
Published: April 2024

Abstract
Background
Recent research has indicated that sex is an important determinant of emergency medical response in patients with possible serious injuries. Men were found to receive more advanced prehospital treatment and more helicopter transportation and trauma centre destinations and were more often received by an activated trauma team, even when adjusted for injury mechanism.
Emergency medical dispatchers choose initial resources when serious injury is suspected after a call to the emergency medical communication centre. This study aimed to assess how dispatchers evaluate primary responses in trauma victims, with a special focus on the sex of the victim.

Methods
Emergency medical dispatchers were interviewed using focus groups and a semistructured interview guide developed specifically for this study. Two vignettes describing typical and realistic injury scenarios were discussed. Verbatim transcripts of the conversations were analysed via systematic text condensation. The findings were reported in accordance with the Consolidated Criteria for Reporting Qualitative Studies (COREQ) checklist.

Results
The analysis resulted in the main category “Tailoring the right response to the patient”, supported by three categories “Get an overview of location and scene safety”, “Patient condition” and “Injury mechanism and special concerns”. The informants consistently maintained that sex was not a relevant variable when deciding emergency medical response during dispatch and claimed that they rarely knew the sex of the patient before a response was implemented. Some of the participants also raised the question of whether the Norwegian trauma criteria reliably detect serious injury in women.

Conclusions
The results indicate that the emergency medical response is largely based on the national trauma criteria and that sex is of little or no importance during dispatch. The observed sex differences in the emergency medical response seems to be caused by other factors during the emergency medical response phase.
Racial/ethnic differences in 21-gene recurrence score and survival among patients with estrogen receptor-positive breast cancer
Authors: Gill Jasmin , Yendamuri Keerti , Chatterjee Udit , Yao Song , Oladeru Oluwadamilola T. , Singh Anurag K. , Ma Sung Jun 
Published: April 2024

Abstract
Background
Despite numerous studies on racial/ethnic disparities among patients with breast cancer, there is a paucity of literature evaluating racial/ethnic differences in 21-gene recurrence score (RS) and survival differences stratified by RS risk categories. We thus performed an observational cohort study to examine racial/ethnic disparities in the context of RS.

Methods
The National Cancer Database (NCDB) was queried for female patients diagnosed between 2006 and 2018 with estrogen receptor (ER)-positive, pT1-3N0-1aM0 breast cancer who received surgery followed by adjuvant endocrine therapy and had RS data available. Logistic multivariable analysis (MVA) was built to evaluate variables associated with RS ≥ 26. Cox MVA was used to evaluate OS. Subgroup analyses were performed to compare the magnitude of racial/ethnic differences stratified by RS. P values less than 0.017 were considered statistically significant based on Bonferroni correction.

Results
A total of 140,133 women were included for analysis. Of these, 115,651 (82.5%), 8,213 (5.9%), 10,814 (7.7%), and 5,455 (3.9%) were NHW, Hispanic, Black, and API women, respectively. Median (IQR) follow up was 66.2 months (48.0–89.8). Logistic MVA showed that, compared with NHW women, Black women were associated with higher RS (≥ 26 vs < 26: adjusted odds ratio [aOR] 1.19, 95% confidence interval [CI] 1.12–1.26, p < 0.001), while HW (aOR 0.93, 95% CI 0.86–1.00, p = 0.04) and API women (aOR 1.03, 95% CI 0.95–1.13, p = 0.45) were not. Cox MVA showed that, compared with NHW women, Black women had worse OS (adjusted hazards ratio [aHR] 1.10, 95% CI 1.02–1.19, p = 0.012), while HW (aHR 0.85, 95% CI 0.77–0.94, p = 0.001) and API (aHR 0.66, 95% CI 0.56–0.77, p < 0.001) women had better OS. In subgroup analysis, similar findings were noted among those with RS < 26, while only API women were associated with improved OS among others with RS ≥ 26.

Conclusion
To our knowledge, this is the largest study using nationwide oncology database to suggest that Black women were associated with higher RS, while HW and API women were not. It also suggested that Black women were associated with worse OS among those with RS < 26, while API women were associated with improved OS regardless of RS when compared to NHW women.
Global burden of self-harm and interpersonal violence and influencing factors study 1990–2019: analysis of the global burden of disease study
Authors: Zhou Xiaoding , Li Ruyu , Cheng Peixia , Wang Xiaonan , Gao Qi , Zhu Huiping 
Published: April 2024

Abstract
Introduction
Widespread concern exists in today’s world regarding self-harm and interpersonal violence. This study to analyze the changes in temporal trends and spatial patterns of risk factors and burdens of self-harm and interpersonal violence using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.

Methods
Temporal trends in self-harm and interpersonal violence were initially summarized using the estimated annual percentage change (EAPC). Data were compiled and visualized to delineate changes in disease burden and factors influencing self-harm and interpersonal violence from 1990 to 2019, stratified by gender, age and GBD region.

Results
In 2019, the DALY rates of self-harm were 424.7(95% UI 383.25, 466.93). Over the period from 1999 to 2019, self-harm exhibited an overall decreasing trend, with the EAPC of -1.5351 (95% CI -1.6194, -1.4507), -2.0205 (95% CI -2.166, -1.8740) and -2.0605 (95% CI -2.2089, -1.9119), respectively. In contrast, the incidence rate of interpersonal violence was significantly higher than self-harm, with a rate of 413.44 (95% UI 329.88, 502.37) per 100,000 population. Mortality and DALYs of interpersonal violence were lower than those of self-harm, at 5.22 (95% UI 4.87, 5.63) and 342.43 (95% UI 316.61, 371.55). Disease burden of self-harm and interpersonal violence varied by gender, age groups and region. Specific risk factors showed that alcohol use, high temperature and drug use were the main risk factors for self-harm, while alcohol use, intimate partner violence and high temperature were associated with interpersonal violence. Low temperature was a common protective factor for both self-harm and interpersonal violence. The burden of self-harm and interpersonal violence was attributed to different factors influences in different SDI regions.

Conclusions
The study explored temporal trends and spatial distribution of the global disease burden of self-harm and interpersonal violence, emphasizing the significant impact of factors such as alcohol use, temperature, and drug use on disease burden. Further research and policy actions are needed to interpret recent changes of disease burden of self-harm and interpersonal violence, and dedicated efforts should be implemented to devise evidence-based interventions and policies to curtail risk factors and protect high-risk groups.