bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparación del tratamiento de fitoterapia vs tratamiento convencional de otitis bacteriana “cocos” en perros
Authors: Velasco Ortiz Mabelén de los Ángeles , Rubio Arias Pablo Giovanny 
Published: March 2024

Introducción. La otitis bacteriana en caninos, marcada por la inflamación del canal auditivo y acumulación de secreciones, tradicionalmente tratada con antibióticos, está siendo reconsiderada debido al interés creciente en la fitoterapia. El árbol de Neem, reconocido por sus propiedades antimicrobianas y antiinflamatorias gracias a componentes como la nimbidina, ha demostrado efectividad en estudios veterinarios para tratar infecciones como la otitis externa en perros. Objetivo. Evaluar el efecto del tratamiento convencional de otitis bacteriana producida por cocos frente a la fitoterapia y comparar el efecto de la fitoterapia en relación al tratamiento convencional. Metodología. Se realizó dos tratamientos para otitis en perros, dividiendo 30 pacientes en dos grupos. El Grupo 1 recibió gel con ciprofloxacina, prednisolona, ketoconazol, lidocaína y corticoides (prednisolona 20 mg) a dosis de 1 mg por kg. Durante 3 días; mientras que el Grupo 2 recibió fitoterapia compuesta por agua, aceite de ricino, aceite de Neem, aceite de menta, preservante y regulador de pH y corticoides (prednisolona 20 mg) a dosis de 1 mg por kg. Durante 3 días. Resultados. El estudio investigó tratamientos para la otitis externa producida por cocos en perros, evidenciando que el tratamiento convencional mostró mayor eficacia en reducir el eritema, la hiperqueratosis y el dolor, mientras que la fitoterapia destacó en controlar la inflamación. La citología reveló diferencias significativas en la disminución de cocos entre ambos tratamientos, siendo la fitoterapia más efectiva. Conclusión. El tratamiento convencional demostró ser más efectivo en reducir los síntomas de la otitis externa en perros, mientras que la fitoterapia mostró potencial en el control de la inflamación y reducción de ciertos microorganismos. Se destaca la importancia del control efectivo del biofilm mediante la limpieza adecuada del oído, para el éxito del tratamiento de la otitis externa en perros producida por cocos. Área de estudio general: Medicina veterinaria Área de estudio específica: Dermatología Tipo de estudio: Artículos originales
EVALUASI AKADEMIK MAHASISWA BIOLOGI TERHADAP PERKULIAHAN GENETIKA DI UNIVERSITAS JEMBER
Authors: Hariyadi Slamet 
Published: March 2024

Pembelajaran abad 21 mempunyai pola yang berbeda dengan abad sebelumnya. Tantangan ini belum banyak direspon oleh para pendidik, termasuk pembelajaran genetika di program studi Pendidikan Biologi FKIP Universitas Jember. Untuk melakukan peningkatan perlu menjaring persepsi mahasiswa. Dari hasil angket didapatkan data bahwa 50% lebih mahasiswa merasa belum mengalami pembelajaran yang berorientasi pada Student Centered Learning (SCL) dan memahami konsep genetika secara mendasar dan mandiri. Diperlukan pendekatan, model, metode, strategi dan taktik belajar variatif untuk memberikan kondisi kelas agar mampu mencapai tujuan pembelajaran yang sesuai dengan tuntutan zaman.Â Â Kata Kunci: pembelajaran abad 21, persepsi mahasiswa, genetika, SCL
The Learning of Mathematics Based on Individual Differences : A Topic Trend Bibliometric Analysis Using VOSviewer
Authors: Sunarto M.J. Dewiyani , Lemantara Julianto 
Published: March 2024

This study aims to establish a foundation for the development of differentiated learning through an analysis of trends in articles related to personality type differences in the field of mathematics education. The research method used was descriptive, using Bibliometric Analysis. These 422 data from Scopus have been from Scopus-indexed journals and were obtained by defining search keywords, namely "individual differences." These articles were then filtered based on the highest citation, resulting in 100 articles that were analyzed using Vos Viewer and Microsoft Excel to display the necessary data for analysis. The results of this study indicated that from many articles that had been analyzed, individual differences have a wide meaning, it could be gender, characteristics, thinking process, fear, attitude, and others. Those differences should be taken into consideration by the teacher and cannot be neglected because they can influence the learners. From the data that has been analyzed, the topic above has been increasing after 2017 with the United States and the United Kingdom as the most recent country that published this topic. Cognition is the journal that has the most publications on this topic, with Engle, R. W. as the most productive writer. The most trending article was about Mathematics in general, mathematics concepts, and the phenomena in teaching and learning math. The next piece of advice is about the development of the individual learning model, its evaluation, and its utilization in creating a differentiated learning model.
Connecting the Dots : How Research-Based Teaching Shapes Teacher Self-Efficacy and Elevates Professional Development in Education
Authors: Jaya Fitra 
Published: March 2024

This study aims to analyze the perception of implementing research-based teaching and teacher self-efficacy in improving professional teaching and learning. This study used a quantitative approach with the survey as a data collection method. 187 teachers were involved in the study spread across three different provincial regions. Data collection was conducted using questionnaires related to teachers' perceptions and self-assessments of research-based teaching, teacher self-efficacy, and professional teaching and learning. The analysis used a two-step approach involving measurement and structural model using structural equation modeling (SEM) analysis. The results showed that research-based teaching has an assential role in improving professional teaching and learning. In addition, teacher self-efficacy also affects the development of teaching and learning professionals, indicating that teacher confidence in their teaching ability has a significant impact on the quality of student learning. The use of research-based teaching by teachers not only increases the efficacy of their teaching, but also positively impacts the learning experience of students, enriching and expanding the quality of learning.
Supporting autistic communities through parent-led and child/young person-led digital social story interventions: an exploratory study
Authors: Camilleri Louis John , Maras Katie , Brosnan Mark 
Published: March 2024

IntroductionSocial Stories (SS) is a socially-valid intervention for autistic children and young people (CYP) which is used widely by professionals and parents. Research suggests that whilst parents are in an ideal position to deliver interventions for their autistic CYP, a lack of procedural integrity can result in a great deal of variability in parent-mediated intervention outcomes.MethodsThis exploratory study investigated the extent to which SS can be effectively developed and delivered, through digital mediation, by parents with little to no researcher input (n = 17, sample 1) and the factors that impact effectiveness. Furthermore, the study also investigated the extent to which digitally-mediated SS can support autistic CYP to develop and deliver their own stories, thereby utilising the intervention as a means for self-support and self-management (n = 5, sample 2).ResultsThe outcomes of the study indicate that digital mediation can effectively support parent-led SS intervention. Findings also indicate that receptive/expressive language skills of autistic CYP, their level of systemizing, as well as the practice of consulting with the autistic CYP whilst identifying goals and developing stories, are individual and procedural characteristics which positively influence the effectiveness of the parent-led intervention. The study also found that digitally-mediated SS can be utilised as a self-support tool by autistic CYP themselves.DiscussionThe results inform the developing literature on digital interventions and support tools that aim to engage with, and involve further, the autistic community in the setting and authoring of interventions and research.
Motilin fluctuations in healthy volunteers determined by liquid chromatography mass spectrometry
Authors: Foreman Rachel E. , Bannon Christopher A. , Kay Richard G. , Reimann Frank , Gribble Fiona M. 
Published: March 2024

IntroductionMotilin is a hormone secreted by specialised enteroendocrine cells in the small intestine, and is known to modulate gastrointestinal motility in humans, regulating the migratory motor complex. It is understudied at least in part due to the lack of commercially available immunoassays.MethodA multiplexed liquid chromatography mass spectrometry (LC-MS/MS) method was optimised to measure motilin, insulin, C-peptide, GIP (1–42) and GIP (3–42). Corresponding active ghrelin concentrations were determined by immunoassay. Ten healthy volunteers with no prior history of gastroenterological or endocrine condition attended after overnight fast and had blood samples taken every 15 minutes for 4 hours whilst continuing to fast, and then further sampling for 2 hours following a liquid mixed meal. Hunger scores were taken at each time point using a visual analogue scale. Normal bowel habit was confirmed by 1 week stool diary.ResultsMotilin levels fluctuated in the fasting state with an average period between peaks of 109.5 mins (SD:30.0), but with no evidence of a relationship with either ghrelin levels or hunger scores. The mixed meal interrupted cyclical motilin fluctuations, increased concentrations of motilin, insulin, C-peptide, GIP(1-42) and GIP(3-42), and suppressed ghrelin levels.DiscussionThis study highlights the utility of LC-MS/MS for parallel measurement of motilin alongside other peptide hormones, and supports previous reports of the cyclical nature of motilin levels in the fasting state and interruption with feeding. This analytical method has utility for further clinical studies into motilin and gut hormone physiology in human volunteers.
A study of forecast sensitivity to observations in the Bay of Bengal using LETKF
Authors: Paul Biswamoy , Baduru Balaji , Paul Arya 
Published: March 2024

IntroductionAssimilating all available observations in numerical models may lead to deterioration of the analysis. Ensemble Forecast Sensitivity to Observations (EFSO) is a method that helps to identify all such observations which benefit the analyses. EFSO has never been tested in an ocean data assimilation system because of a lack of robust formulation of a squared norm against which beneficiality of observations can be estimated.MethodsHere, we explore the efficacy of EFSO in the ocean data assimilation system that comprises the ocean model, Regional Ocean Modeling System (ROMS), coupled to the assimilation system Local Ensemble Transform Kalman Filter (LETKF), collectively called LETKF- ROMS, in the Bay of Bengal by envisaging a novel squared norm. The Bay of Bengal is known for its higher stratification and shallow mixed layer depth. In view of baroclinicity representing the stratification of the ocean, we use the modulus of the baroclinic vector as the squared norm to evaluate forecast errors in EFSO.ResultsUsing this approach, we identify beneficial observations. Assimilating only the beneficial observations greatly improves the ocean state. We also show that the improvements are more pronounced in the head of the Bay of Bengal where stratification is much higher compared to the rest of the basin.DiscussionThough this approach doesn’t degrade the ocean state in other regions of the Indian Ocean, a universal squared norm is needed that can be extended beyond the Bay of Bengal basin.
Clinical observation of a modified technique for intrascleral fixation of flanged three-piece foldable intraocular lenses through a Hoffman pocket
Authors: Ye Hongfei , Wu Mengxiao , Sun Wan , Lyu Jiao , Xu Yu , Fei Ping , Peng Jie , Jin Haiying , Zhao Peiquan 
Published: March 2024

PurposeTo present the outcomes of a new technique for intrascleral fixation of a flanged three-piece foldable intraocular lens (IOL) without a conjunctival incision.Materials and methodsWe retrospectively reviewed a consecutive series of 12 eyes of 12 patients who underwent scleral IOL fixation using this technique.ResultsThe follow-up period ranged 3–12 months. There was a significant improvement in best-corrected visual acuity, from 0.8 (1.6) logarithm of the minimum angle of resolution (logMAR) preoperatively to 0.45 (0.8) logMAR at the final postoperative follow-up (p = 0.012). Notable complications included one case of pupillary IOL capture and increased intraocular pressure.ConclusionOur novel technique is a viable solution for managing secondary IOL fixation, enabling the use of a wider variety of IOLs and simplifying the reposition process for dislocated three-piece IOLs. This approach has the potential to lower complication rates and enhance patients’ recovery.
Structural volumetric and Periodic Table DTI patterns in Complex Normal Pressure Hydrocephalus—Toward the principles of a translational taxonomy
Authors: Lock Christine , Toh Emma M. S. , Keong Nicole C. 
Published: March 2024

IntroductionWe previously proposed a novel taxonomic framework to describe the diffusion tensor imaging (DTI) profiles of white matter tracts by their diffusivity and neural properties. We have shown the relevance of this strategy toward interpreting brain tissue signatures in Classic Normal Pressure Hydrocephalus vs. comparator cohorts of mild traumatic brain injury and Alzheimer’s disease. In this iteration of the Periodic Table of DTI Elements, we examined patterns of tissue distortion in Complex NPH (CoNPH) and validated the methodology against an open-access dataset of healthy subjects, to expand its accessibility to a larger community.MethodsDTI measures for 12 patients with CoNPH with multiple comorbidities and 45 cognitively normal controls from the ADNI database were derived using the image processing pipeline on the brainlife.io open cloud computing platform. Using the Periodic Table algorithm, DTI profiles for CoNPH vs. controls were mapped according to injury patterns.ResultsStructural volumes in most structures tested were significantly lower and the lateral ventricles higher in CoNPH vs. controls. In CoNPH, significantly lower fractional anisotropy (FA) and higher mean, axial, and radial diffusivities (MD, L1, and L2 and 3, respectively) were observed in white matter related to the lateral ventricles. Most diffusivity measures across supratentorial and infratentorial structures were significantly higher in CoNPH, with the largest differences in the cerebellum cortex. In subcortical deep gray matter structures, CoNPH and controls differed most significantly in the hippocampus, with the CoNPH group having a significantly lower FA and higher MD, L1, and L2 and 3. Cerebral and cerebellar white matter demonstrated more potential reversibility of injury compared to cerebral and cerebellar cortices.DiscussionThe findings of widespread and significant reductions in subcortical deep gray matter structures, in comparison to healthy controls, support the hypothesis that Complex NPH cohorts retain imaging features associated with Classic NPH. The use of the algorithm of the Periodic Table allowed for greater consistency in the interpretation of DTI results by focusing on patterns of injury rather than an over-reliance on the interrogation of individual measures by statistical significance alone. Our aim is to provide a prototype that could be refined for an approach toward the concept of a “translational taxonomy.”
Unveiling gender differences in psychophysiological dynamics: support for a two-dimensional autonomic space approach
Authors: Menashri Sinai Yarden , Ma Yaopeng X. J. , Abba Daleski Michal , Gannot Sharon , Bartsch Ronny P. , Gordon Ilanit 
Published: March 2024

IntroductionTo date, studies focusing on the connection between psychological functioning and autonomic nervous system (ANS) activity usually adopted the one-dimensional model of autonomic balance, according to which activation of one branch of the ANS is accompanied by an inhibition of the other. However, the sympathetic and parasympathetic branches also activate independently; thus, co-activation and co-inhibition may occur, which is demonstrated by a two-dimensional model of ANS activity. Here, we apply such models to assess how markers of the autonomic space relate to several critical psychological constructs: emotional contagion (EC), general anxiety, and positive and negative affect (PA and NA). We also examined gender differences in those psychophysiological relations.MethodsIn the present study, we analyzed data from 408 healthy students, who underwent a 5-min group baseline period as part of their participation in several experiments and completed self-reported questionnaires. Electrocardiogram (ECG), electrodermal activity (EDA), and respiration were recorded. Respiratory sinus arrhythmia (RSA), pre-ejection period (PEP), as well as cardiac autonomic balance (CAB) and regulation (CAR) and cross-system autonomic balance (CSAB) and regulation (CSAR), were calculated.ResultsNotably, two-dimensional models were more suitable for predicting and describing most psychological constructs. Gender differences were found in psychological and physiological aspects as well as in psychophysiological relations. Women's EC scores were negatively correlated with sympathetic activity and positively linked to parasympathetic dominance. Men's PA and NA scores were positively associated with sympathetic activity. PA in men also had a positive link to an overall activation of the ANS, and a negative link to parasympathetic dominance.DiscussionThe current results expand our understanding of the psychological aspects of the autonomic space model and psychophysiological associations. Gender differences and strengths and weaknesses of alternative physiological models are discussed.
Association between plasma polyunsaturated fatty acids and depressive among US adults
Authors: Wang Man , Yan Xiaofang , Li Yanmei , Li Qian , Xu Yingxia , Huang Jitian , Gan Juan , Yang Wenhan 
Published: March 2024

BackgroundDepression is associated with greater functional impairment and high societal costs than many other mental disorders. Research on the association between plasma polyunsaturated fatty acids (PUFAs) levels and depression have yielded inconsistent results.ObjectiveTo evaluate whether plasma n-3 and n-6 PUFAs levels are associated with depression in American adults.MethodsA cross-sectional study included 2053 adults (aged ≥20 y) in the National Health and Nutrition Examination Survey (NHANES), 2011–2012. The level of plasma n-3 and n-6 PUFAs were obtained for analysis. Self-reported Patient Health Questionnaire-9 (PHQ-9) was used to identify the depression status. Binary logistic regression analysis was performed to evaluate the association between quartiles of plasma n-3 and n-6 PUFAs and depression after adjustments for confounders.ResultsThe study of 2053 respondents over 20 years of age with a weighted depression prevalence of 7.29% comprised 1,043 men (weighted proportion, 49.13%) and 1,010 women (weighted, 50.87%), with a weighted mean (SE) age of 47.58 (0.67) years. Significantly increased risks of depression over non-depression were observed in the third quartiles (OR = 1.65, 95% CI = 1.05–2.62) for arachidonic acid (AA; 20:4n-6); the third quartiles (OR = 2.20, 95% CI = 1.20–4.05) for docosatetraenoic acid (DTA; 22:4n-6); the third (OR = 2.33, 95% CI = 1.34–4.07), and highest quartiles (OR = 1.83, 95% CI = 1.03–3.26) for docosapentaenoic acid (DPAn-6; 22:5n-6); and the third (OR = 2.18, 95% CI = 1.18–4.03) and highest quartiles (OR = 2.47, 95% CI = 1.31–4.68) for docosapentaenoic acid (DPAn-3; 22:5n-3); the second (OR = 2.13, 95% CI = 1.24–3.66), third (OR = 2.40, 95% CI = 1.28–4.50), and highest quartiles (OR = 2.24, 95% CI = 1.08–4.69) for AA/docosahexaenoic acid (DHA; 22:6n-3) ratio compared with the lowest quartile after adjusting for confounding factors.ConclusionHigher plasma levels of AA, DTA, DPAn-6, DPAn-3 PUFAs, and AA/DHA ratio may be potential risk factors for depression in US adults.
Radical prostatectomy versus radiotherapy as local therapy for primary tumors in patients with oligometastatic prostate cancer
Authors: Ham Won Sik , Park Jee Soo , Jang Won Sik , Kim Jongchan 
Published: March 2024

IntroductionWe compared radical prostatectomy (RP) and radiotherapy (RT) as local therapies for primary tumors and examined their associations with survival outcomes and urinary tract complications in patients with oligometastatic prostate cancer (omPC).MethodsWe evaluated the data of 85 patients diagnosed with omPC who underwent local therapy for primary tumors between January 2008 and December 2018. Of the 85 patients, 31 underwent prostate RT, while 54 underwent RP. Oligometastatic disease was defined as the presence of fewer than five metastatic lesions without visceral metastasis. Urinary tract complications, progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS) were evaluated using the Kaplan–Meier method and Cox regression analyses. ResultsPatients treated with RT showed higher prostate-specific antigen levels. There was no significant difference in the 5-year PFS (52.5% vs. 37.9%, p=0.351), CSS (67.6% vs. 84.7%, p=0.473), or OS (63.6% vs. 73.8%, p=0.897) between the RT and RP groups. In the multivariate analyses, the type of local therapy was not associated with PFS (hazard ratio [HR]=1.334, p=0.356), CSS (HR=0.744, p=0.475), or OS (HR=0.953, p=0.897). ConclusionTherefore, RP seems to be a possible treatment option for patients with omPC, exhibiting oncologic outcomes comparable to those with RT.