bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of loss to follow‐up in the Dutch organised HPV‐based cervical cancer screening programme
Authors: Olthof E. M. G. , Aitken C. A. , Siebers A. G. , van Kemenade F. J. , de Kok I. M. C. M. 
Published: March 2024

AbstractLoss to follow‐up (LTFU) within cervical screening programmes can result in missed clinically relevant lesions, potentially reducing programme effectiveness. To examine the health impact of losing women during the screening process, we determined the proportion of women LTFU per step of the Dutch hrHPV‐based screening programme. We then determined the probability of being LTFU by age, screening history and sampling method (self‐ or clinician‐sampled) using logistic regression analysis. Finally, we estimated the number of missed CIN2+/3+ lesions per LTFU moment by using the CIN‐risk in women compliant with follow‐up. Data from the Dutch nationwide pathology databank (Palga) was used. Women eligible for screening in 2017 and 2018 were included (N = 840,428). For clinician collected (CC) samples, the highest proportion LTFU was found following ‘referral advice for colposcopy’ (5.5% after indirect referral; 3.8% after direct referral). For self‐sampling, the highest proportions LTFU were found following the advice for repeat cytology (13.6%) and after referral advice for colposcopy (8.2% after indirect referral; 4.3% after direct referral). Self‐sampling users and women with no screening history had a higher LTFU‐risk (OR: 3.87, CI: 3.55–4.23; OR: 1.39, CI: 1.20–1.61) compared to women that used CC sampling and women that have been screened before, respectively. Of all women LTFU in 2017/18, the total number of potentially missed CIN2+ was 844 (21% of women LTFU). Most lesions were missed after ‘direct referral for colposcopy’ (N = 462, 11.5% of women LTFU). So, this indicates a gap between the screening programme and clinical care which requires further attention, by improving monitoring of patients after referral.
Micromesh reinforced strain sensor with high stretchability and stability for full‐range and periodic human motions monitoring
Authors: Liu Haidong , Liu Chang , Luo Jinan , Tang Hao , Li Yuanfang , Liu Houfang , Wu Jingzhi , Han Fei , Liu Zhiyuan , Guo Jianhe , Tan Rongwei , Ren Tian‐Ling , Qiao Yancong , Zhou Jianhua 
Published: March 2024

AbstractThe development of strain sensors with high stretchability and stability is an inevitable requirement for achieving full‐range and long‐term use of wearable electronic devices. Herein, a resistive micromesh reinforced strain sensor (MRSS) with high stretchability and stability is prepared, consisting of a laser‐scribed graphene (LSG) layer and two styrene‐block‐poly(ethylene‐ran‐butylene)‐block‐poly‐styrene micromesh layers embedded in Ecoflex. The micromesh reinforced structure endows the MRSS with combined characteristics of a high stretchability (120%), excellent stability (with a repetition error of 0.8% after 11 000 cycles), and outstanding sensitivity (gauge factor up to 2692 beyond 100%). Impressively, the MRSS can still be used continauously within the working range without damage, even if stretched to 300%. Furthermore, compared with different structure sensors, the mechanism of the MRSS with high stretchability and stability is elucidated. What's more, a multilayer finite element model, based on the layered structure of the LSG and the morphology of the cracks, is proposed to investigate the strain sensing behavior and failure mechanism of the MRSS. Finally, due to the outstanding performance, the MRSS not only performes well in monitoring full‐range human motions, but also achieves intelligent recognitions of various respiratory activities and gestures assisted by neural network algorithms (the accuracy up to 94.29% and 100%, respectively). This work provides a new approach for designing high‐performance resistive strain sensors and shows great potential in full‐range and long‐term intelligent health management and human–machine interactions applications.image
Multifaceted roles of PDCD6 both within and outside the cell
Authors: Zhu Yigao , Li Qingchao 
Published: March 2024

AbstractProgrammed cell death protein 6 (PDCD6) is an evolutionarily conserved Ca2+‐binding protein. PDCD6 is involved in regulating multifaceted and pleiotropic cellular processes in different cellular compartments. For instance, nuclear PDCD6 regulates apoptosis and alternative splicing. PDCD6 is required for coat protein complex II‐dependent endoplasmic reticulum‐to‐Golgi apparatus vesicular transport in the cytoplasm. Recent advances suggest that cytoplasmic PDCD6 is involved in the regulation of cytoskeletal dynamics and innate immune responses. Additionally, membranous PDCD6 participates in membrane repair through endosomal sorting complex required for transport complex‐dependent membrane budding. Interestingly, extracellular vesicles are rich in PDCD6. Moreover, abnormal expression of PDCD6 is closely associated with many diseases, especially cancer. PDCD6 is therefore a multifaceted but pivotal protein in vivo. To gain a more comprehensive understanding of PDCD6 functions and to focus and stimulate PDCD6 research, this review summarizes key developments in its role in different subcellular compartments, processes, and pathologies.
Novel method of image analysis that combines Radon and Fourier image transformations for the purpose of differentiating between malignant and benign colonic biopsies
Authors: Faibis Chen , Sabo Edmond , Mazareb Salam , Klorin Geula 
Published: March 2024

AbstractColorectal cancer is the third most common type of cancer. It develops slowly as a polyp that can turn into a cancerous tumor. This study aimed to develop a decision‐making algorithm of microscopic images using texture analysis that is orientation free, to be used for automated classification of normal and neoplastic (malignant or premalignant) colonic biopsies. Forty‐nine colonic adenocarcinomas, 41 adenomas and a control group of adjacent normal colonic mucosa were included in the texture analysis. Radon transform followed by the Fast Fourier transform were applied to the images. Subsequently, the gray level co‐occurrence matrix (GLCM) transform was applied allowing the extraction of four textural variables (homogeneity, contrast, correlation, and entropy). For classification and prediction of the diagnosis, a statistical multivariate regression model and a neural network (NNET) model were used and compared. The statistical model provided a sensitivity of 71.3% and a specificity of 50% (Area under the ROC curve: 0.67) for classifying the neoplastic and the normal images, respectively. The NNET model was superior to the statistical model and produced a sensitivity of 97.9% and specificity of 88% (Area under the ROC curve: 0.92). To our knowledge, this is the first study that used a combination of Radon, FFT, and GLCM transformations in order to overcome the tissue orientation problem in texture analysis of microscopic images of colonic biopsies. The NNET classifier trained by the extracted textural features proved to be superior to the statistical classifier, thus predicting colonic neoplasia with high accuracy.Research Highlights
We propose a novel decision‐making algorithm of orientation invariant image texture analysis, fast and easily implemented for automated differentiation between benign and neoplastic epithelial tumors of the colon. This method can reduce the turnaround time allowing to prioritize the biopsies during their examination and diagnosis by the pathologist.
Melatonin counteracts cadmium‐induced rat testicular toxicity via the mechanistic target rapamycin (mTOR) pathway
Authors: Rhouma Mariem B. , Venditti Massimo , Haddadi Asma , Knani Latifa , Chouchene Lina , Boughammoura Sana , Reiter Russel J. , Minucci Sergio , Messaoudi Imed 
Published: March 2024

AbstractThe protective action of melatonin (MLT) against the harmful effects of cadmium (Cd) on testicular activity in rats has been documented previously; however, the involved molecular mechanisms have yet to be elucidated. Herein, we investigate the involvement of the mammalian target of rapamycin (mTOR) on the ability of MLT to counteract the damage induced by Cd on the rat testicular activity. Our study confirmed that Cd has harmful effects on the testes of rats and the protective action exerted by MLT. We reported, for the first time, that the addition of rapamycin (Rapa), a specific mTOR inhibitor, to animals co‐treated with Cd and MLT completely abolished the beneficial effects exerted by MLT, indicating that the mTOR pathway partially modulates its helpful effects on Cd testicular toxicity. Interestingly, Rapa‐alone treatment, provoking mTOR inhibition, produced altered morphological parameters, increased autophagy of germ and somatic cells, and reduced serum testosterone concentration. In addition, mTOR inhibition also reduced protein levels of markers of steroidogenesis (3β‐Hydroxysteroid dehydrogenase) and blood–testis barrier integrity (occludin and connexin 43). Finally, Rapa altered sperm parameters as well as the ability of mature spermatozoa to perform a proper acrosome reaction. Although further investigation is needed to better clarify the molecular pathway involved in MLT action, we confirm that MLT alleviating Cd effects can be used as a supplement to enhance testicular function and improve male gamete quality.
Blubber biopsy in common bottlenose dolphins using a novel biopsy puncher: Evaluation of the impact on living individuals and possibility of applications in cetacean research
Authors: Funasaka Noriko , Suzuki Miwa , Hosono Masayuki , Shindo Hideaki , Kawamura Keiko , Inamori Daiki , Yoshioka Motoi 
Published: March 2024

AbstractBiopsy has recently become a preferred protocol for sampling the skin and blubber of many cetacean species, although it is desirable to collect as minimally invasive as possible. Here, the effect of biopsy sampling on the captive common bottlenose dolphins was evaluated by analyzing the process of wound healing and changes in hematological and blood biochemical parameters after biopsy using a puncher developed to collect up to the inner layer of the dolphin blubber. Results showed that the wounds caused by biopsy were closed in as early as 1 day and completely covered with the epidermis within 5–11 days. Blood fibrinogen, which generally increases due to a wound‐induced inflammatory response or activation of the coagulation system, was significantly elevated after the biopsy indicating ongoing tissue repair, while other parameters did not exhibit significant differences. Furthermore, histological observation and RNA extraction of samples were performed to investigate the versatility of this method to cetacean research. Histological examination revealed three distinct layers of the blubber in the biopsy samples. Moreover, total RNA extracted from biopsy samples exhibited sufficient quality and quantity for gene expression analyses. Overall, the puncher utilized in our study represents a valuable and minimally invasive tool for investigating various aspects of small cetacean studies.
Is there any association between celiac disease, myelodysplastic symdrome and primary sclerosing cholangitis?: A rare case report
Authors: Hamsho Suaad , Hariri Moudar Al , sleiay Bilal , alhussen Abdul hadi daher , Sleiay Mouhammed 
Published: March 2024

AbstractCeliac disease (CD) is an autoimmune disease characterized by a specific serological and histological profile. Hematological findings are one of the most common presentations and can sometimes be the only manifestation of the disease. In patients with unexplained isolated hematological abnormalities, a high index of suspicion for CD is necessary. A 33‐year‐old woman was admitted to the Department of Gastroenterology and Hepatology because of abdominal pain and fatigue. She was diagnosed with myelodysplastic syndrome. After many investigations, it is explained that she has CD. It is important to consider myelodysplastic syndrome as a hematological manifestation of CD. All patients with myelodysplasia should be investigated for CD and related conditions such as primary sclerosing cholangitis.
Orientations of graphs with maximum Wiener index
Authors: Li Zhenzhen , Wu Baoyindureng 
Published: March 2024

AbstractIn this paper, we study the Wiener index of the orientation of trees and theta‐graphs. An orientation of a tree is called no‐zig‐zag if there is no subpath in which edges change the orientation twice. Knor, Škrekovski, and Tepeh conjectured that every orientation of a tree achieving the maximum Wiener index is no‐zig‐zag. We disprove this conjecture by constructing a counterexample. Knor, Škrekovski, and Tepeh conjectured that among all orientations of the theta‐graph with and , the maximum Wiener index is achieved by the one in which the union of the paths between and forms a directed cycle of length , where and are the vertex of degree 3. We confirm the validity of the conjecture.
Exploring Latine students’ perceptions of their high school counselors’ capitalization of community cultural wealth
Authors: Vela Javier Cavazos , Guerra Federico , Zamora Elizabeth , Perez Erika 
Published: March 2024

AbstractThis qualitative study explored the experiences of Latine college students with their high school counselors about community cultural wealth. The study aimed to understand how high school counselors cultivated Latine students’ navigational, aspirational, linguistic, familial, social, and resistant capital. Data were collected through semistructured interviews with eight Latine college students attending a Hispanic‐Serving Institution. The findings revealed that high school counselors supported Latine students’ navigational and aspirational capital but did not cultivate their linguistic, familial, social, and resistant capital. Implications for practice include the need for culturally appropriate interventions, advocacy for better student–counselor ratios, and using the ASCA National Model and Empowerment Model to design interventions that cultivate Latine students’ community cultural wealth.
Ferumoxytol‐Enhanced Cardiac Cine MRI Reconstruction Using a Variable‐Splitting Spatiotemporal Network
Authors: Gao Chang , Ming Zhengyang , Nguyen Kim‐Lien , Pang Jianing , Bedayat Arash , Dale Brian M. , Zhong Xiaodong , Finn J. Paul 
Published: March 2024

BackgroundBalanced steady‐state free precession (bSSFP) imaging is commonly used in cardiac cine MRI but prone to image artifacts. Ferumoxytol‐enhanced (FE) gradient echo (GRE) has been proposed as an alternative. Utilizing the abundance of bSSFP images to develop a computationally efficient network that is applicable to FE GRE cine would benefit future network development.PurposeTo develop a variable‐splitting spatiotemporal network (VSNet) for image reconstruction, trained on bSSFP cine images and applicable to FE GRE cine images.Study TypeRetrospective and prospective.Subjects41 patients (26 female, 53 ± 19 y/o) for network training, 31 patients (19 female, 49 ± 17 y/o) and 5 healthy subjects (5 female, 30 ± 7 y/o) for testing.Field Strength/Sequence1.5T and 3T, bSSFP and GRE.AssessmentVSNet was compared to VSNet with total variation loss, compressed sensing and low rank methods for 14× accelerated data. The GRAPPA×2/×3 images served as the reference. Peak signal‐to‐noise‐ratio (PSNR), structural similarity index (SSIM), left ventricular (LV) and right ventricular (RV) end‐diastolic volume (EDV), end‐systolic volume (ESV), and ejection fraction (EF) were measured. Qualitative image ranking and scoring were independently performed by three readers. Latent scores were calculated based on scores of each method relative to the reference.StatisticsLinear mixed‐effects regression, Tukey method, Fleiss' Kappa, Bland–Altman analysis, and Bayesian categorical cumulative probit model. A P‐value <0.05 was considered statistically significant.ResultsVSNet achieved significantly higher PSNR (32.7 ± 0.2), SSIM (0.880 ± 0.004), rank (2.14 ± 0.06), and latent scores (−1.72 ± 0.22) compared to other methods (rank >2.90, latent score < −2.63). Fleiss' Kappa was 0.52 for scoring and 0.61 for ranking. VSNet showed no significantly different LV and RV ESV (P = 0.938) and EF (P = 0.143) measurements, but statistically significant different (2.62 mL) EDV measurements compared to the reference.ConclusionVSNet produced the highest image quality and the most accurate functional measurements for FE GRE cine images among the tested 14× accelerated reconstruction methods.Level of Evidence3Technical EfficacyStage 1
Identifying COVID‐19 subtypes by single‐sample gene set enrichemnt analysis and providing guidance for sensitive drug selection
Authors: Xiong Nan , Sun Qiangming 
Published: March 2024

AbstractThis study aimed at using single‐sample gene set enrichment analysis scores to cluster naso/pharyngeal swab specimen samples from coronavirus disease 2019 (COVID‐19) patients into two clusters. One cluster with higher fractions of immune cells and more active inflammatory‐related pathways was called the Immunity‐High (Immunity‐H) group, and the other one was called the Immunity‐Low group. We explored impacts of the method on COVID‐19 treatment. First, given that the Immunity‐H group was mainly enriched in inflammatory‐related pathways and had higher fractions of inflammatory cells, the Immunity‐H group may obtain more curative effects from anti‐inflammatory treatment. Second, we searched some hot genes from the PubMed platform that had been studied by researchers and found these genes upregulated in the Immunity‐H group, so we speculated the Immunity‐H group and Immunity‐Low group may have different curative effects from drugs targeting these genes. Finally, we screened out hub genes for the Immunity‐H group and predicted potential drugs for these hub genes by a public data set (http://dgidb.genome.wustl.edu). These hub genes are significantly upregulated in the Immunity‐H group and neutrophils so that the Immunity‐H group may obtain different treatment results from potential drugs compared with the Immunity‐Low group. Therefore, the cluster method may provide help in drug development and administration for COVID‐19 patients.
Improved fluorescence‐based assay for rapid screening and evaluation of SARS‐CoV‐2 main protease inhibitors
Authors: Zhang Rui , Yan Haohao , Zhou Jiahao , Yan Gangan , Liu Xiaoping , Shang Chao , Chen Yunyu 
Published: March 2024

AbstractThe outbreak of coronavirus disease 2019 (COVID‐19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a global threat to human health. In parallel with vaccines, efficacious antivirals are urgently needed. SARS‐CoV‐2 main protease (Mpro) is an attractive drug target for antiviral development owing to its key roles in virus replication and host immune evasion. Due to the limitations of currently available methods, the development of novel high‐throughput screening assays is of the highest importance for the discovery of Mpro inhibitors. In this study, we first developed an improved fluorescence‐based assay for rapid screening of Mpro inhibitors from an anti‐infection compound library using a versatile dimerization‐dependent red fluorescent protein (ddRFP) biosensor. Utilizing this assay, we identified MG‐101 as a competitive Mpro inhibitor in vitro. Moreover, our results revealed that ensitrelvir is a potent Mpro inhibitor, but baicalein, chloroquine, ebselen, echinatin, and silibinin are not. Therefore, this robust ddRFP assay provides a faithful avenue for rapid screening and evaluation of Mpro inhibitors to fight against COVID‐19.
Tomorrow is already here: Exploring how corporate foresight can contribute to ambidexterity
Authors: van der Duin Patrick , Trott Paul , Marzi Giacomo 
Published: March 2024

AbstractCorporate foresight involves strategically exploring multiple potential futures and serves as a tool to guide organizational decision‐making processes. Despite its significance, a predominant focus on immediate, short‐term issues often characterizes the operational mindset of many companies. As a result, companies frequently encounter challenges in achieving organizational ambidexterity—the ability to balance and leverage both the exploitation of current capabilities and the exploration of new opportunities in the future. In this paper, we propose a theoretical investigation of corporate foresight. We develop a conceptual framework that delineates different relationships between corporate foresight and organizational ambidexterity, providing a structured approach to understand how these concepts interact and influence each other. Our framework proposes three ways corporate foresight can significantly enhance ambidexterity within organizations. First, corporate foresight can be pivotal in identifying and analyzing future trends and disruptions, which can inform strategic decision‐making. Secondly, corporate foresight can better align an organization's long‐term strategic goals and short‐term operational objectives, thus enhancing ambidexterity. Finally, corporate foresight can bridge different organizational units, promoting collaboration and knowledge sharing, aiding in developing a holistic approach to strategic planning that encompasses daily operational excellence and future‐oriented strategic posture.
Effect of Potentilla anserina L. powder on gel properties and volatile flavor characteristics of silver carp surimi
Authors: Li Wenting , Liu Hongchao , Zhang Zhen , Liu Yiyi , Zhang Xuehua , Qu Yinghong , Shi Wenzheng 
Published: March 2024

AbstractBACKGROUNDPotentilla anserina L. is rich in various nutrients, active ingredients and unique flavor, comprising a natural nutrition and health food. However, its application in aquatic food has been rarely reported. Therefore, the effects of Potentilla anserina L. powder (PAP) on gel properties and volatile flavor profile of silver carp surimi were investigated.RESULTSThe gel strength and water‐holding capacity of the surimi gels were significantly improved (P < 0.05), and the whiteness and cooking loss of all the samples decreased slightly with the increase in PAP content. The addition of PAP shortened the relaxation time (T2) of the surimi gels and converted some of the free water into immobile or bound water, which resulted in a better immobilization of water in the surimi. Scanning electron microscopy images demonstrated that the network of surimi gels with PAP added was denser and had a smoother surface compared to the control. Volatile components (VCs) analysis showed that 33 VCs were identified in the surimi gel samples with different additions of PAP, among which aldehydes, alcohols and esters were the major VCs, accounting for more than 50% of the VCs in the surimi gels. PAP addition reduced the fishy and rancid flavor compounds in surimi gels, such as 1‐propanol, 1‐octen‐3‐ol, etc., and promoted the production of aldehydes, alcohols, esters and other flavor substances.CONCLUSIONThese results of the present study provide theoretical support for the investigation and development of new nutrient‐health‐flavored surimi products. © 2024 Society of Chemical Industry.