bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community integration, quality of life, thriving, and mental health among refugees and asylum seekers. A London service provider perspective
Authors: Kienzler Hanna 
Published: April 2024

IntroductionThis article explores how systemic injustices and social inequalities affect refugee and asylum seeker integration, thriving, and mental health in London. This is pertinent as the United Kingdom currently operates a ‘broken’ asylum system with unfair policies and a ‘tough’ immigration rhetoric which makes it extraordinarily difficult for asylum seekers and refugees to achieve community integration, have a good quality of life, be able to thrive, and have good health including mental health. Paradoxically, the United Kingdom Home Office also features an Indicators for Integration Framework to provide practical ways to design more effective strategies, monitor services and evaluated integration interventions.MethodsThis study employed a qualitative research design including semi-structured interviews with 19 mental health and psychosocial support service providers working in third-sector organizations in London.ResultsThe study results show that the current asylum system severely undermines efforts to support asylum seekers and refugees with their integration. All participants highlighted that asylum seekers and refugees lacked experienced poor quality of life and faced structural challenges to build meaningful social connections; to have access education, fair employment and good work; to achieve good mental health and wellbeing; and to be able to thrive.DiscussionTo improve community integration, quality of life, thriving, and mental health for asylum seekers and refugees in London and, beyond, the United Kingdom, four recommendations are made on structural and service-levels: (1) reform of the current asylum system by centering human rights; (2) implement and carry out needs assessments among asylum seekers and refugees focussing on key social determinants; (3) ensure asylum seekers and refugees benefit from the NHS Inclusion Health framework; and (4) extend the NHS Patient and Carer Race Equality framework beyond England. To be effective, all four initiatives need to be grounded in a participatory approach that meaningfully involves diverse groups of stakeholders including asylum seekers and refugees.
Morphological, clinical, and molecular profiling of post-polycythemia vera accelerated/blast phase occurring with and without antecedent secondary myelofibrosis
Authors: Pelagatti Laura , Pozzi Giulia , Cortellazzi Samuele , Mancini Cristina , Martella Eugenia , Pagliaro Luca , Giaimo Mariateresa , Roti Giovanni , Vitale Marco , Carubbi Cecilia , Masselli Elena 
Published: April 2024

IntroductionPolycythemia vera (PV) is a JAK2-mutated myeloproliferative neoplasm (MPN) characterized by clonal erythrocytosis and an intrinsic risk of transformation into acute myeloid leukemia (AML), known as blast-phase (BP) disease, a condition typified by dismal prognosis. In PV, the evolution to BP generally occurs through an overt fibrotic progression, represented by the post-PV myelofibrotic (MF) stage. However, direct leukemic transformation from PV may also occur in up to ~50% of patients. In this study, we sought to shed light on the morphological, clinical, and molecular features that may differentiate BP arising from a direct transition from the PV stage (post-PV-BP) from those evolving through a diagnosis of post-PV myelofibrosis (post-PV-MF-BP). Methods and resultsWe retrospectively analyzed a cohort of post-PV-BP (n=5) and post-PV-MF-BP (n=5). We found that BP arising from PV directly displayed significantly lower leukocyte count (median 2.93 × 109/L, range: 2.30–39.40 vs. median 41.05 × 109/L, range: 5.46–58.01; P=0.03), and spleen diameter (14.0 cm, range: 11.5–20.0 vs. 25.5 cm, range: 18–26; P=0.03) as compared to those experiencing an overt fibrotic stage. The most striking differences emerged from bone marrow (BM) morphological analysis: all post-PV-BP were characterized by significantly higher cellularity (median 70%, range: 60%–98% vs. 28%, range: 2%–41%, P=0.0245), lower degree of fibrosis (fibrosis grade 1 vs. fibrosis grade 3 in all cases, P=0.008) and dysplastic features involving all three lineages, most prominently the erythroid and megakaryocytic compartment. Next-generation sequencing (NGS) analysis revealed that post-PV-BP cases were enriched in mutations located in genes involved in DNA methylation such as DNMT3A, IDH1/2, and TET2 (45% vs. 15%, P=0.038). DiscussionWith all the limits of the small number of patients for each cohort, our data suggest that BPs that arise directly from PV present a peculiar phenotype, consistent with the molecular signature of the disease, typified by mutations of genes occurring with a high frequency in Myelodysplastic Syndromes (MDS) and MDS/MPN. Further studies in larger cohorts are warranted to translate these observations into robust evidence that may advise therapeutic choices.
Development of an implementation science informed “Test Evidence Transition” program to improve cancer outcomes
Authors: Hamilton-West Kate E. , Feast Alexandra , Masento Natalie A. , Knowles Brian , Sloan Claire , Weaver Luke 
Published: April 2024

IntroductionTranslation of cancer research into practice takes around 15 years. Programs informed by implementation science methods and frameworks offer potential to improve cancer outcomes by addressing the implementation gap.MethodsWe describe the development of a Test Evidence Transition (TET) program which provides funding and support to health system delivery teams and project design and evaluation partners working together to achieve three objectives: Test innovations to support optimal cancer pathways that transform clinical practice; Evidence the process, outcome, and impact of implementation; and work with strategic partners to ensure the Transition of best practice into effective and equitable adoption across UK health systems.ResultsPhase 1 launched in April 2023. Teams with the capability and motivation to implement evidence-based pathway innovations were identified and invited to submit expressions of interest. Following peer-review, teams were supported to develop full proposals with input from academics specializing in health services research, evaluation, and implementation science. Projects were selected for funding, providing an opportunity to implement and evaluate innovations with support from academic and health system partners.ConclusionsTET aims to improve cancer outcomes by identifying and addressing local-level barriers to evidence-based practice and translating findings into consistent and equitable adoption across health systems. Phase 1 projects focus on pathway innovations in diagnosis for breast and prostate cancer. We are now launching Phase 2, focusing on colorectal cancer.
Infectious Diseases and Basal Ganglia Calcifications: A Cross-Sectional Study in Patients with Fahr’s Disease and Systematic Review
Authors: Snijders Birgitta M. G. , Peters Mike J. L. , van den Brink Susanne , van Trijp Marijke J. C. A. , de Jong Pim A. , Vissers Laurens A. T. M. , Verduyn Lunel Frans M. , Emmelot-Vonk Marielle H. , Koek Huiberdina L. 
Published: April 2024

Background: It is unclear whether patients with basal ganglia calcifications (BGC) should undergo infectious disease testing as part of their diagnostic work-up. We investigated the occurrence of possibly associated infections in patients with BGC diagnosed with Fahr’s disease or syndrome and consecutively performed a systematic review of published infectious diseases associated with BGC. Methods: In a cross-sectional study, we evaluated infections in non-immunocompromised patients aged ≥ 18 years with BGC in the Netherlands, who were diagnosed with Fahr’s disease or syndrome after an extensive multidisciplinary diagnostic work-up. Pathogens that were assessed included the following: Brucella sp., cytomegalovirus, human herpesvirus type 6/8, human immunodeficiency virus (HIV), Mycobacterium tuberculosis, rubella virus, and Toxoplasma gondii. Next, a systematic review was performed using MEDLINE and Embase (2002–2023). Results: The cross-sectional study included 54 patients (median age 65 years). We did not observe any possible related infections to the BGC in this population. Prior infection with Toxoplasma gondii occurred in 28%, and in 94%, IgG rubella antibodies were present. The positive tests were considered to be incidental findings by the multidisciplinary team since these infections are only associated with BGC when congenitally contracted and all patients presented with adult-onset symptoms. The systematic search yielded 47 articles, including 24 narrative reviews/textbooks and 23 original studies (11 case series, 6 cross-sectional and 4 cohort studies, and 2 systematic reviews). Most studies reported congenital infections associated with BGC (cytomegalovirus, HIV, rubella virus, Zika virus). Only two studies reported acquired pathogens (chronic active Epstein–Barr virus and Mycobacterium tuberculosis). The quality of evidence was low. Conclusions: In our cross-sectional study and systematic review, we found no convincing evidence that acquired infections are causing BGC in adults. Therefore, we argue against routine testing for infections in non-immunocompromised adults with BGC in Western countries.
Fine Mapping of qAL5.2 Controlling Anther Length in Oryza sativa
Authors: Liu Xinyong , Yu Zixuan , Tong Xiaohong , Chang Longxue , Huang Jie , Wang Yifeng , Ying Jiezheng , Li Xingwang , Ni Shen , Zhang Jian 
Published: April 2024

Anther length is the critical floral trait determining hybrid rice seed production and is controlled by many quantitative trait loci (QTL). However, the cloning of genes specifically controlling anther size has yet to be reported. Here, we report the fine mapping of qAL5.2 for anther size using backcross inbred lines (BILs) in the genetic background of Oryza sativa indica Huazhan (HZ). Gene chip analysis on the BC4F2 and BC5F1 population identified effective loci on Chr1, Chr5, and Chr8 and two genomic regions on Chr5, named qAL5.1 and qAL5.2. qAL5.2 was identified in both populations with LOD values of 17.54 and 10.19, which explained 35.73% and 25.1% of the phenotypic variances, respectively. Ultimately qAL5.2 was localized to a 73 kb region between HK139 and HK140 on chromosome 5. And we constructed two near-isogenic lines (NILs) for RNA-seq analysis, named NIL-qAL5.2HZ and NIL-qAL5.2KLY, respectively. The result of the GO enrichment analysis revealed that differential genes were significantly enriched in the carbohydrate metabolic process, extracellular region, and nucleic acid binding transcription, and KEGG enrichment analysis revealed that alpha-linolenic acid metabolism was significantly enriched. Meanwhile, candidate genes of qAL5.2 were analyzed in RNA-seq, and it was found that ORF8 is differentially expressed between NIL-qAL5.2HZ and NIL-qAL5.2KLY. The fine mapping of qAL5.2 conferring anther length will promote the breed improvement of the restorer line and understanding of the mechanisms driving crop mating patterns.
Environment Modifying in Inclusive Education
Authors: Cathrine Asha S. , Blessing Mary A. 
Published: April 2024

The goal of inclusive education is to give all students equal opportunities to learn, without regard to their abilities, backgrounds, or needs. To achieve this, it is essential to alter the educational environment to meet the distinct requirements of each learner. Visual schedules, tactile materials, and auditory aids are some of the sensory resources available in inclusive classrooms to cater to different sensory preferences. To promote focus and comfort, learners can opt for adaptable seating and quiet spaces. An environment that fosters inclusivity is as much about culture as physical elements. It is critical to cultivate an atmosphere of empathy, understanding, and respect. Among all students, a sense of belonging, peer support, and open dialogue can be encouraged by recognising and commending their differences and unique qualities. Environment modification in inclusive education, improved by changing surroundings, is a key method for giving excellent education that appreciates students’ diversity. By making these changes, schools and teachers can aid in making surethat every student has an equalchance to learn, join in, and do well in school.
Fostering Support and Empowering Learners in Inclusive Education
Authors: Rubina J. 
Published: April 2024

The crucial component of guidance and counselling in the framework of inclusive education, placing a strong emphasis on nurturing support and empowerment for learners. The primary goal of inclusive education is to accommodate the diverse needs of all students, irrespective of their varying abilities and backgrounds. Guidance and counseling assume a pivotal role in establishing an inclusive environment through the provision of tailored support, addressing individual challenges, and cultivating a sense of empowerment among learners. The various strategies and practices employed in guidance and counseling to ensure inclusivity, with a dedicated focus on fostering the holistic development of students. A system of education that is inclusive must prioritise participation and guidance. Effective implementation of inclusive education, ensuring fair access, participation, and success for all learners, involves offering advice and assistance to teachers, individualised student support, encouraging community and family involvement, and promoting inclusive policies
The Online Behavioural Advertising Tripod: Understanding the Linkages between Users’ Knowledge, Privacy Concerns and Customers’ Attitude
Authors: Priyanka  , Siraj Sadaf 
Published: April 2024

Online Behavioural Advertising (OBA) is a marketing technique of providing personalized advertisements to targeted customers, because it involves personal data collection that consumers feel privacy-conscious. This study aims to establish interlinkages between the knowledge about OBA, privacy concerns, customer atitude and OBA acceptance in the context of Indian consumers. Based on literature review, it was identified that the knowledge about OBA and privacy concerns are the two consumer-controlled factors. A study framework was developed to guide the study based on literture review.
With the help of an online survey, a sample of 104 responses was collected and the results were identified with equal number of males and females. The results suggest that increasing the knowledge about OBA with reduction in the privacy concerns is the need of the hour. Marketers and other stakeholders must work to increase the knowledge about OBA among consumers. Reducing the privacy concerns could increase the positive attitude towards OBA. This will further increase the chances of OBA acceptance. The observations of the current study could be used by future researchers as well as by marketers while formulating their policies involving targeting advertising.
Health Education-Based Group on Self-care Adherence among Patients with Diabetes Mellitus in Cendrawasih Public Health Center, Makassar City
Authors: Hasniati Hasniati , Harbaeni Harbaeni , Yusuf Saldy , Masriadi Masriadi 
Published: April 2024

Background: Self-care is crucial strategy to improve and maintain health condition among diabetes patients. However, most type 2 DM patients are disobedient in carrying out self-care. Objective: The study aimed to examine the effect of health education on self-care adherence among patients with diabetes mellitus in Cendrawasih Public Health Center, Makassar city. Method: A quantitative study with pre-experimental approach, two group, pretest and posttest design were applied in this study. Thirty-six diabetes mellitus patients were involved in this study using the total sampling technique since limited number of patients in this Public Health Center. We divided into the experimental group (n=18) and the control group (n=18). The Wilcoxon test was used to analyzed the data. Result: The results found that there are significantly difference on self-care adherence among type 2 diabetes mellitus before and after receiving the health education with p-value <.05. Conclusion: The health education was effective to improve the understanding of diabetes patients who carry out the self-care in maintaining the self-care. Recommendation: Further study need to apply the wide of study using the Randomized Control Trial (RCT) to ensure the effectiveness of health education using varied of strategy on health outcomes
Social Anxiety Levels among Adolescents at Social Child Welfare Institutions in Pekanbaru City
Authors: Adhara Hajar , Erika Erika , Wahyuni Sri 
Published: April 2024

Background: Social anxiety is a fear of getting negative judgments from others when individuals are involved in certain social activities or situations. Social anxiety can also be experienced by teenagers who live in Social Child Welfare Institutions. Objective: This study aims to obtain an overview of the level of social anxiety in adolescents who live in Social Child Welfare Institutions in Pekanbaru City. Method: This quantitative study used a descriptive survey method, with a cluster random sampling technique of 240 adolescents as a sample. The research instrument is the Liebowitz Social Anxiety Scale questionnaire. Result: The results of this study indicate that 69.7% of the 240 adolescents living in Social Child Welfare Institutions experienced social anxiety. The dominating level is mild social anxiety (33.8%), followed by moderate social anxiety (21.3%), marked social anxiety (10%), severe social anxiety (3.8%), and very severe social anxiety (0.8%). The social situation that makes most respondents feel afraid or anxious is going to a party or event (74.2%), while the most avoidance response is urinating in a public toilet (55.2%). Conclusion: It can be concluded that adolescents living in Social Child Welfare Institutions experience social anxiety at various levels. Therefore, this research intends to make related institutions (Social Services) cooperate with Social Child Welfare Institutions to pay more attention to teenagers' development. Support can be in the form of providing facilities and health professionals who can help prevent social anxiety from escalating into a more severe condition or even causing other mental illnesses
Analysis Concept; Continuing Care of Post-Intensive Care Syndrome
Authors: Lahati Nurul Safira , Suhartini Suhartini , Anggorowati Anggorowati 
Published: April 2024

Background: ICU aftercare is characterized by various physical, emotional, cognitive, and psychosocial symptoms that appear while receiving care in the Intensive Care Unit and continue after discharge and will negatively affect the patient's quality of life. Objective: Analyzing continuing care to refine the definition and analyze what is needed in continuing care after treatment in the ICU. Method: The article searches used data based on PubMed, Clinical Key, and Science Direct. Walker and Avant's approach was used to guide this concept analysis, which consisted of eight steps, namely concept selection, Continuing care), determining the purpose of the analysis; analyzing Continuing care to refine the definition, and analyze what are the needs in continuing care after treatment in the ICU), identifying all uses of the concept, defining its attributes, identifying antecedents and consequences, identifying model cases, identifying reverse cases and identifying empirical references from defining empirical attributes. Result: Some of the attributes of the concept of continuous care include monitoring and management of post-critical illness symptoms, planning transitions of care from the ICU to the ward, patient education and guidance, and solving problems in overcoming the obstacles faced by post-ICU patients. Recommendation: Provide standard guidelines or protocols for the continuing care of post-ICU patients. The analysis concept can provide scientific evidence and practice to manage patients with post-ICU care syndrome
Prevalence of Interstitial Lung Disease in Patients with Chronic Cough Taking Chest X-rays and CT Chest as Diagnostic Tools
Authors: Khan Abdul Qadeer , Nayyar Shaista , Khalid Sohaib , Taqi Irum , Khan Murtaza Ahmed 
Published: April 2024

Introduction: With well over 200 types of pulmonary disorders, ILD is a growing global health burden with chronic cough being the most frequent symptom. As it hampers the basic respiratory mechanism, it eventually deteriorates the overall quality of life. The diagnosis of ILD is quite challenging and the accuracy rates with conventional tests are quite low.
Material and methods: A cross-sectional study on 200 patients was performed in Sir Ganga Ram Hospital, Lahore, Pakistan. The study took place from the period of 15th April to 15th July 2023. Chest X-ray (CXR) and Computed Tomography (CT) Chest were used as diagnostic tools.
Results: The chest x-ray detected ILD in 114 (57%) while the chest CT identified in 178 (89%) of the patients. CXR and CT had a sensitivity of 65.05 and 95.65 and a specificity of 45.1 and 85.2 respectively. CXR and CT detected reticular opacity, nodular opacity, and ground glass opacity in 66% vs 81%, 41% vs 78%, and 33% vs 55% of the ILD patients. Dyspnoea (85%), fever (30%), arthralgia (24%), and weight loss (9%) were found as clinical indications.
Conclusion: CXR can be used to perform initial preliminary tests to filter out the presence of other diseases in patients with ILD. However, it cannot be solely relied on as a diagnostic tool. CT Chest can be the choice of imaging modality in diagnosing ILD as it outperformed CXR in many aspects of our study, with better precision, accuracy, sensitivity, and specificity.
Prediction of the radon priority areas in the Slovak Republic and its experimental verification
Authors: Brandýsová Alžbeta , Holý Karol , Bulko Martin , Müllerová Monika , Eckertová Terézia , Masarik Jozef 
Published: April 2024

Background: The identification of the areas with increased indoor radon levels, generally referred to as “radon priority areas”, is an internationally recognized issue. Many scientific studies propose methods for locating such areas using measured soil characteristics.
Objective: To utilize a modified Neznal radon potential classification for mapping radon potential across the Slovak Republic and experimentally verifying the predictions of radon priority areas.
Methods: The study applied a modified version of the Neznal radon potential classification, using measurements of soil air radon concentration and soil gas permeability, to develop a radon potential map for the Slovak Republic. Municipalities with high radon potential were primarily selected for the experimental verification of radon priority area predictions. The verification process involved comparing measured indoor radon activity concentrations against predicted values, which were derived from a previous study correlating averaged indoor radon activity concentrations with averaged Neznal radon potential for selected municipalities.
Results: The investigation revealed an approximately linear relationship between the measured indoor radon activity concentrations and their predicted values, with a correlation coefficient R2 = 0.43. Notably, in one municipality predicted to have medium-high radon potential, indoor radon concentrations exceeded the reference level of 300 Bq.m-3 even in buildings constructed after 2008, highlighting the significant influence of soil radon content on indoor levels despite stricter building material standards. The analysis of radon priority areas in relation to bronchial and lung cancer mortality data across various districts in Slovakia did not show statistically significant results.
Conclusion: The proposed method of predicting radon risk areas is important for radiation protection of the population against high effective doses of radon and can contribute to the successful implementation of the National Radon Action Plan of the Slovak Republic.