bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skip mediastinal lymph node metastasis in non‐small cell lung cancer
Authors: Tateishi Masahiro , Fukuyama Yasuro , Hamatake Motoharu , Kohdono Satoshi , Ishida Teruyoshi , Sugimachi Keizo 
Published: February 2007

AbstractWe retrospectively investigated 186 non‐small cell lung cancer cases with N2 disease in order to clarify the significance of skip metastasis. Of the 186 patients with N2 disease, negative N1 nodes recognized to be skip metastasis were seen in 62 patients (33%). The incidence of skip metastasis was not statistically different regarding histology, T status, or M status. The incidence of the skip metastatic site consisted of 35 cases (56%) at sites 1, 2 and 3, while 8 cases (13%) were found at sites 8 and 9. Among the patients with right lung cancer, the skip metastatic incidence for site 7 (subcarinal) was higher in patients with either middle lobe or lower lobe cancer than in those with upper lobe cancer (P < 0.05). The 5‐year survival rates of all N2 patients in comparison to those with skip metastasis were 22% and 24%, respectively. When the sites of mediastinal lymph nodes were classified as superior, aortic, and inferior, the 5‐year survival rates of the patients with superior skip metastasis, aortic metastasis, and inferior metastasis were 23%, 36%, and 15%, respectively. No statistical difference was observed. The 5‐year survival rate of the skip N2 patients with only aortic region involvement was 50% (n=7). However, no statistically significant difference was found between the two groups (P=0.08). Our results thus suggested that mediastinal involvement for the aortic region alone might have a better prognosis than the others. We thus conclude that a dissection of the complete hilar and mediastinal lymph nodes should be the procedure of choice in standard operations for non‐small cell lung cancer because of the high frequency of skip metastasis. © 1994 Wiley‐Liss, Inc.
Lymph node involvement correlation with survival in advanced gastric carcinoma: Univariate and multivariate analyses
Authors: Shimoyama Shouji , Kaminishi Michio , Joujima Yoshiaki , Oohara Takeshi , Hamada Chikuma , Teshigawara Wataru 
Published: February 2007

AbstractThe aim of this study was to elucidate what factors affect the survival of patients with advanced gastric carcinoma. The relationship between the survival of 282 patients over a period of 15 years and 12 prognostic factors was investigated. In univariate analysis, lymph node involvement, depth of invasion, gross form, type of operation, maximum tumor diameter, and lymphatic invasion were found to correlate significantly with survival. Lymph node involvement, gross form, type of operation, and depth of invasion were selected by the Cox proportional hazard model with variable selection methods and found significant. Lymph node involvement was shown to correlate most significantly with survival by both univariate and multivariate analyses. Kaplan‐Meier survival curves could indicate that the survival rates of the selected factors were worsening in proportion to the relative risk ratios. These results suggest that further contrivance of therapies should be considered for patients in high risk categories. © 1994 Wiley‐Liss, Inc.
Effect of improved diagnosis of renal cell carcinoma on the course of the disease
Authors: Kessler Oded , Mukamel Eliahu , Gillon Gabriel , Servadio Ciro , Hadar Herzlia , Konechezky Miriam 
Published: February 2007

AbstractThe impact of the improved diagnosis of renal cell carcinoma (RCC) on the course of the disease was evaluated in 188 patients who were diagnosed and treated at a single medical center. Sixty‐seven patients (group A) who had undergone nephrectomy between 1979 and 1983 for RCC initially diagnosed by intravenous pyelography (IVP) were compared with 121 patients (group B) who had undergone nephrectomy between 1983 and 1989, diagnosed by ultrasound and/or computed tomography (CT) scan. Incidental asymptomatic tumors were found in 18 of 67 (26.9%) group A patients and in 57 of 121 (47.1%) group B patients (P < 0.001). The incidence of small tumors of <5 cm in diameter was significantly lower in group A compared to group B (25.4% vs. 47.9%, respectively, P < 0.01). The disease‐free 5‐year survival rate for group A was 40% compared to 80% for group B. It is concluded that the introduction of modern imaging techniques has improved the survival of patients with RCC and decreased the progression rate of the disease. © 1994 Wiley‐Liss, inc.
Clinical significance of multidrug resistance and P‐glycoprotein expression in patients with gastric carcinoma
Authors: Fujii Hidenori , Tanigawa Nobuhiko , Muraoka Ryusuke , Shimomatsuya Takumi , Tanaka Takeo 
Published: February 2007

AbstractTwenty‐four fresh tumors of gastric carcinoma were assessed by flow cytometric detection of P‐glycoprotein (P‐gp) using monoclonal antibody C219. Eight patients were P‐gp positive. Differentiated gastric carcinomas contained significantly higher concentrations of P‐gp positive. Incidence of P‐gp positive was high in advanced stage. In 16 cases estimated chemosensitivity was test assessed by thymidine incorporation assay (TIA). Seven of nine multidrug‐resistant cases according to TIA were P‐gp positive and all of seven nonmultidrug resistant cases were P‐gp negative. Expression of P‐gp and multidrug resistance were closely correlated (P< 0.01). Also, in 89 patients with operable gastric carcinoma, the relation between in vitro chemosensitivity test (TIA) and their clinicopathologic features as well as their survival lengths were studied. Thirty‐one of 89 specimens from gastric carcinoma patients were multidrug resistant according to TIA. Patients in the multidrug‐resistant group had a significantly poorer cumulative survival rate than those who were not multidrug resistant (P< .05). The multivariate analysis showed that multidrug resistance is a useful indicator of prognosis (P< 0.1). We suggest that multidrug‐resistant cases or P‐gp‐positive cases of gastric carcinoma are highly malignant, and these determinations are clinically useful. © 1995 Wiley‐Liss, Inc.
Breast cancer complicated by pleural effusion: Patient characteristics and results of surgical management
Authors: Apffelstaedt Justus P. , van Zyl J. A. , Muller A. G. S. 
Published: February 2007

AbstractTo evaluate the efficiency of pleurodesis (PD) in the management of symptomatic malignant pleural effusion (PE) in breast cancer, we reviewed 46 patients undergoing 49 PDs. When radiotherapy was part of the initial treatment, 41% of PEs were ipsilateral to the primary, if not, 85% of PEs were ipsilateral (P < 0.0075). Six percent of patients presented dyspneic with exertion, 32% during daily routine; 61% at rest. All except 1 were improved after PD; 74% had no dyspnea, 23% had exertional dyspnea. PD relieved chest pain in 4 and cough in 5 patients. With 31 Talc/Iodine PDs, 2 mortalities and 2 minor complications occurred. Of 17 tetracycline PDs, 1 was complicated by bronchopleural fistula and 1 failed. 1 Mustine PD was uncomplicated. Survival at 6, 12, and 24 months was 58%, 40%, and 13%, respectively. Primary local radiotherapy may prevent ipsilateral PE. Talc/Iodine and tetracycline PD reliably provide relief from the distressing symptoms of malignant PE. © 1995 Wiley‐Liss, Inc.
Gastric cancer in the young, with special reference to 14 pregnancy‐associated cases: Analysis based on 2,325 consecutive cases of gastric cancer
Authors: Maeta Michio , Yamashiro Hiroshi , Oka Atsuo , Tsujitani Shunichi , Ikeguchi Masahide , Kaibara Nobuaki 
Published: February 2007

AbstractClinicopathologic features of gastric cancer in young women were analyzed with special reference to pregnancy (P). Among 2,325 consecutive patients, there were 152 young patients under 40 years of age (57 males and 95 females), and 14 P‐associated cases were identified. The male‐to‐female ratio was 1.7:1.0 on the whole, but 1.0:1.7 in the young group with more females predominating as the age of patients decreased. Among characteristics of gastric cancer in the young females, we noted a significantly higher frequency of both Borrmann type 4 cancer and poorly differentiated adenocarcinoma with the scirrhus type of growth and peritoneal metastasis. These characteristics were more pronounced in the P‐associated cases. Although we were unable to determine the mechanism for these tendencies, our findings suggest that the development and growth of gastric cancer in young women may be influenced by their natural, biological and hormonal circumstances. The prognosis of the young women with or without associated pregnancy was good afer curative surgery. Both early detection of gastric cancer and subsequent potentially curative surgery are the best ways to obtain good survival for young women, as is the case for members of other age and sex groups. © 1995 Wiley‐Liss, Inc.
Ovarian mucinous cystadenocarcinoma with sarcoma‐like mural nodules
Authors: Hamada Tetsuo , Sasaguri Takakazu , Tanimoto Akihide , Arima Nobuyuki , Nakano Ryuji , Sasaguri Yasuyuki , Miyayama Haruhiko 
Published: February 2007

AbstractA rare case of ovarian mucinous cystadenocarcinoma with sarcoma‐like mural nodules is reported. Macroscopically, nodular or granular lesions were scattered over the inner surface of a huge, multilocular tumor in the left ovary. The histopathological features were consistent with those of previously documented cases, except significant squamous metaplasia in the present case. The pleomorphic sarcoma‐like cells showed a positive reaction for vimentin and α‐antichymotrypsin but were negative for carcinoembryonic antigen and common epithelial membrane antigen by immunohistochemistry. Electron microscopically, the tumor cells had neither desmosomes nor secretory granules, but they possessed abundant intermediate filaments. Both immunostaining and ultrastructure suggested that the sarcoma‐like nodules were derived from reactive proliferation of fibrohis‐tiocytic cells. The fibrohistiocytic reaction seemed to occur in response to hemorrhage, because hemorrhage was reported to be associated with the mural nodules in most of the previous cases as well as ours. © 1995 Wiley‐Liss, Inc.
Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: The effect of sulindac
Authors: Waddell William R. , Miesfeld Roger L. 
Published: February 2007

AbstractA putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation of adenylate cyclase, uncoupling of cAMP synthesis from prostaglandin, and inactivation of protein kinase A (PKA). It is suggested that in normal cells, (APC) protein binds to catenins and microtubules to maintain structure and contribute to cell‐cell communication, adherence, and the dephosphorylated state, a necessary condition for such functions. Cells with mutant APC product become isolated, deprived of communication and adhesion to other epithelial cells, overphosphorylated, and without corrective capability. The latter is largely due to downregulation of cAMP synthesis and protein kinase A activity secondary to high prostaglandin. Three main biochemical defects ensue: (1) the restrictive influence of PKA catalyzed phosphorylation of Raf‐1 kinase and resultant effects on the MAP kinase cascade and transcription is lost, (2) the transcription of immediate early genes, including cyclooxygenase is stimulated, and (3) the stimulation of protein tyrosine phosphatase (PTPase) by PKA is in abeyance.These putative abnormalities are reversed by inhibition of cyclooxygenase‐1 by sulindac. cAMP synthesis and PKA activity return to normal. PKA catalyzed phosphorylations block Raf‐1 kinase at the confluence of the Ras and protein kinase C pathways. The MAP kinase cascade is inhibited as is transcription of immediate early genes. At the same time PKA stimulates PTPase, which dephosphorylates the cytoskeleton and restores cell‐cell communication, adherence, and structure. The transformed phenotype is circumvented by adjustment of the phosphorylation state and mutant cells rejoin the epithelial community. The redox state of cytoplasm in mutant cells may be shifted toward reduction. © 1995 Wiley‐Liss, Inc.
Wilmss' tumor: The northern israel oncology institute experience
Authors: Arush Myriam Weyl Ben , Nahum Monique Peretz , Maor Jehuda‐Adi Bar , Dale Janet , Kuten Abraham 
Published: February 2007

AbstractBetween 1971 and 1992, 42 children (median age = 2 years) with histologically proven Wilms' tumor were evaluated at the Northern Israel Oncology Institute. Most patients were staged according to National Wilms' Tumor Study (NWTS) criteria by which 18 were clinical stage I‐II and 24 were III‐IV. Combined therapy (surgery, chemotherapy, and radiotherapy) was given with a change to lower dose radiotherapy (<2,000cG) after 1981. The pre‐1981 group (13 patients) suffered six relapses, most of which were pulmonary, whereas the 1981‐1992 group (29 patients) had three relapses. The actuarial 5‐year survival rate using Kaplan‐Meier tables was 79% for the entire group but 100% for the 1981‐1992 group and 38% for the 1971‐1980 group. One case of immediate hepatic toxicity and one sudden death, unknown cause, of a patient in remission occurred in the group. Late deleterious effects were seen in five other patients; four had scoliosis and one developed osteoid osteoma of a rib. Despite these encouraging results, the necessity of ongoing monitoring for further longterm toxicities is apparent.
DNA ploidy and PCNA index in pancreatic lesions producing hyperinsulinemic hypoglycemia
Authors: Losada J. , Sarria R. , Fernandez Val J. F. , Lopez Ariztegui M. A. 
Published: February 2007

AbstractDNA nuclear content and PCNA index (proportion of PCNA reactive cells) have been studied by flow cytometry in eight pancreatic lesions producing hyperinsulinemic hypoglycemia to assess DNA ploidy and tumoral growth fraction. Adult nesidioblastosis had a diploid DNA index, two adenomas were near diploid, and four of the adenomas and the carcinoma were aneuploid. The median value of PCNA index (6.056% ± 6.76) was significantly correlated (p <0.05) with the mean tumor diameter (2.43 cm ± 1.96). Tumors with a PCNA index <6.056% showed a diameter less than the mean tumoral diameter and a benign clinical course. Tumors with PCNA index <6.056% generally displayed a diameter bigger than the mean tumoral diameter, being associated with lymph node metastases in one case. The authors conclude that nuclear DNA and PCNA index cytometric studies are useful parameters to assess the biological behaviour of pancreatic lesions producing hyperinsulinemic hypoglycemia.
Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder
Authors: Pandey Manoj , Khatri Ajay K. , Dubey Sheo S. , Gautam Amitabh , Shukla Vijay K. 
Published: February 2007

AbstractErythrocyte fatty acids were determined in patients with gall stones and carcinoma of the gallbladder. Significantly low levels of myristic acid (p < 0.01) and stearic acid (p < 0.001) and significantly high levels of palmitoleic acid (p < 0.05) and oleic acid (p < 0.01) were observed in cancer patients. Arachidonic and linolenic acid were significantly high in gallstone patients, but there was no significant difference in the lauric acid and palmitic acid levels. Thus an altered lipid metabolism in cancer patients suggest existence of a possible association between gallstones, fatty acids, and carcinoma of the gallbladder.
Value of high‐resolution intraoperative ultrasonography in the determination of limits of horizontal tumor spread during surgery for gastric malignancy
Authors: Demirci Salim , Cetin Recep , Yerdel Mehmet Ali , Kocaoglu Hilmi , Tunc Gunduz , Unal Muttalip 
Published: February 2007

AbstractDetermination of the resection margins during surgery for gastric malignancy is a subject of controversy because accurate detection of horizontal limits of tumor spread is difficult by current methods. In this study, we investigated the value of intraoperative‐ultrasonography (IUS) in the detection of proximal and distal limits of horizontal tumor spread (HTS) in 19 gastric adenocarcinoma (Group I) and five gastric lymphoma (Group II) patients. After sonographic and clinical limits of HTS were marked, resections were carried out 2 cm away from the IUS limits, and biopsies from IUS limits and resection margins were obtained. Then, the gap between IUS and clinical limits were recorded and compared with results of pathology. In both groups, the distance from clinical to IUS limits ranged from 0 cm to 3 cm and IUS limits were never inside the clinical limits. In Group I, results of sonographic proximal limit detection were satisfactory in all patients excluding recurrent cases (n:2) and a patient with early gastric cancer. Sonographic accuracy of distal limit detection was 68%. In Group I, only one resection margin (distal) was found to be infiltrated with cancer. In Group II, the success rate of IUS‐guided HTS detection was 40%. IUS seems to be a valuable method for determining the extent of HTS during operation for gastric adenocarcinomas, especially so for the most problematic proximal limits. In recurrent cancers and lymphomas, however, results of IUS may be frequently misleading. IUS can be advocated as a routine procedure to determine the tumor limits and thus the resection margins during surgery for primary gastric adenocarcinomas.
Carcinoma of the axillary breast
Authors: Evans Douglas M. , Guyton Daniel P. 
Published: February 2007

AbstractA review of the world literature regarding carcinoma of ectopic breast tissue along with the addition of one cases is reported. A total of 90 cases of carcinoma of ectopic breast tissue were found, 64 of which occurred in the axilla. The combined survival beyond the 4‐year post‐treatment period was 9.4%. No survival advantage was found for radical or modified radical mastectomy over that of local excision combined with axillary dissection or radiation. The addition of radiation therapy to either type of mastectomy provided no additional benefit. The correct preoperative diagnosis was rarely made. Outcome was reported in 42 cases; 28 survived longer than 1 year, with 12 recurrences at the time of reporting, and 6 were alive with no evidence of disease at 4 years or longer. Improved prognosis requires diagnostic suspicion and early biopsy of unidentified lesions of the axilla or embryonic milk line.
Bipedicle delayed flap closure of persistent radiated tracheocutaneous fistulas
Authors: Jacobs John R. 
Published: February 2007

AbstractIncreasing numbers of patients have had tracheostomies for prolonged periods of time and when subsequently decannulated have developed persistent tracheocutaneous fistula. A substantial percentage of these patients have undergone successful combined modality therapy excluding surgery for advanced head and neck cancer with resulting healing deficits of the remaining tissues. Although these patients may be deemed suitable for decannulation at this particular point, the potential still exists that access to the trachea will be required sometime in the future. This situation requires a method of closure that is reasonably reliable and yet, at the same time, relatively easily reversible. The surgical technique presented appears to meet these demands.After primary inversion of the edges of the tracheocutaneous fistula, a bipedicle flap is developed and positioned over the tracheostomy site. The inferior edge of the flap is left open for temporary air escape to decompress the suture line. This line subsequently heals by secondary intention over the succeeding weeks. Although there has not been, to date, the need to reverse the closure, the relative thinness of the tissue as opposed to alternative techniques suggests that it should not be difficult.
Taxol and platinum chemotherapy in the treatment of pancreatic and jejunal carcinoma
Authors: Cornelison Terri L. , Goldberg Jeffrey M. , Steven Piver M. 
Published: February 2007

AbstractPancreatic cancer and jejunal cancer are aggressive diseases with grim prognoses. The long term survival of pancreatic carcinoma is still one of the worst of all cancers. Ninety‐five percent of the patients die of their disease within 5 years [Wagener et al: Ann Oncol 5(Suppl 3): S87‐S90, 1994]. Eighty‐five percent of patients with jejunal carcinoma die of their disease within 5 years [Lioe, Biggart: J Clin Pathol 43: 533‐536, 1990]. To date, there are disappointingly few effective cytotoxic agents in the treatment of these cancers.We present a case of advanced‐stage pancreatic carcinoma and a case of advanced stage jejunal carcinoma, each showing marked response to Taxol and platinum chemotherapy.
Curative resection of gastric cancer: Limitation of peritoneal lavage cytology in predicting the outcome
Authors: Abe Shun'Ichi , Yoshimura Hiroshi , Tabara Hideki , Tachibana Mitsuo , Monden Naomi , Nakamura Teruhisa , Nagaoka Saburou 
Published: February 2007

AbstractPatients with stage T3N0∼2M0 gastric carcinoma (n = 108) were studied for relevant prognostic factors. Peritoneal lavage cytology (PLC) was performed in all. In univariate analysis, 5‐year survival rates were better with smaller serosal invasion (diameter <3.0 cm vs. ≥3.0 cm, 61% vs. 37%,P< 0.05) and fewer metastatic nodes (≤5 vs. ≥6, 57% vs. 29%,P< 0.05). In multivariate analyses, only these two factors were significant. The predictive value of PLC was not shown in both univariate and multivariate analyses. Peritoneal recurrence occured in 14 (22%) of 77 patients with negative PLC, and in 3 (18%) of 17 with positive PLC, the difference being not significant. Our results indicate that PLC is insensitive in predicting the development of peritoneal recurrence. Its role in the estimation of survival is limited, as many will die of visceral or locoregional recurrence if not of peritoneal dissemination.
Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma
Authors: Kitamura Kaoru , Kuwano Hiroyuki , Watanabe Masayuki , Nozoe Tadahiro , Yasuda Mitsuhiro , Sumiyoshi Kohei , Saku Motonori , Sugimachi Keizo 
Published: February 2007

AbstractFrom January 1988 to June 1992, 66 patients with resectable squamous cell carcinoma of the thoracic esophagus underwent preoperative adjuvant therapy. These patients were prospectively divided into two treatment groups; 32 were treated with radiofrequency wave local hyperthermia combined with chemoradiotherapy (hyperthermochemoradiotherapy; HCR), while the remaining 34 patients were treated with chemoradiotherapy alone (CR).There were no procedural complications in either group and the postoperative mortality was zero. In the HCR group, no viable cancer cells were found within the entire 5 mm‐width slices of the resected specimen in eight patients (25%), while only two (5.9%) in the CR group (P < 0.05) demonstrated no viable cancer cells. The cumulative 3‐year survival rate was 50.4% in the HCR group and 24.2% in the CR group.The present prospective trial demonstrated that the addition of hyperthermia to chemoradiotherapy resulted in a better local control and an improved long‐term survival when treating patients with advanced esophageal carcinoma. © 1995 Wiley‐Liss, Inc.