bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of clinical profiles, surgical experience and outcomes of ileosigmoid knotting in low‐resource setup: A retrospective cohort study at Jimma University Medical Center
Authors: Bayleyegn Nebiyou Simegnew , Zelelew Abebe Nega , Sisay Assefa Legesse 
Published: March 2024

AbstractBackgroundBowel obstruction is a mechanical or functional blockade of intestinal contents from evacuation to the adjacent distal bowel or external environment. It poses significant morbidity and mortality in both high‐income and low‐to‐middle‐income countries. Ileosigmoid knotting is a special form of obstruction where the small bowel often ileum wraps around the sigmoid colon or vice versa. It is the severest form of bowel obstruction, involving both the small and large bowels in a compound manner. It is common where sigmoid volvulus is common and geographic areas with a bulky diet.MethodsAn institution‐based retrospective cohort study was employed among purposively selected 40 surgical patients with ileosigmoid knotting records from July 2020 to July 2023 at Jimma University Medical Center. To estimate and compare the survival probabilities, the Kaplan‐Meir method and log‐rank test were used. A Cox‐regression analysis was fitted to identify independent predictors of time to death.ResultsAmong a cohort of 40 patients followed for 347 person‐days at Jimma University Medical Center, 11 (27.5%) had died. The overall incidence rate of death was 3.2 (95% CI 1.8, 5.7) per 100 person‐days. In multivariable Cox‐regression analysis, age (AHR = 1.15; 95% CI: 1.04–1.28), shock at presentation (AHR = 30.50: 95% CI 1.25–742.54), comorbidities (AHR = 5.81; 95% CI 1.19–28.23), pulse rate intraoperatively (AHR = 1.19; 95% CI: 1.01–1.40), postoperative pulse rate (AHR = 1.07; 95% CI: 1.01–1.14) were independently associated with time to death.ConclusionThe incidence of death among surgical patients with ileosigmoid knotting was high and also had a shorter median survival time. Age, shock at presentation, comorbidities, pulse rate intraoperatively, and postoperative pulse rate were found to be statistically significant predictors of time to death and outcome among surgical patients with Ileosigmoid knotting.
A low‐cost, DIY tourniquet simulator with built‐in self‐assessment for prehospital providers in Guatemala city
Authors: Jhunjhunwala Rashi , Monzon Jose , Faria Isabella , Escalona Gabriel , Zinco Analia , Ottolino Pablo , Reyna Favio , Raykar Nakul , Asturias Sabrina 
Published: March 2024

AbstractBackgroundHemorrhage is the leading cause of preventable death after trauma. In high‐income countries first responders are trained in hemorrhage control techniques but this is not the case for developing countries like Guatemala. We present a low‐cost training model for tourniquet application using a combination of virtual and physical components.MethodsThe training program includes a mobile application with didactic materials, videos and a gamified virtual reality environment for learning. Additionally, a physical training model of a bleeding lower extremity is developed allowing learners to practice tourniquet application using inexpensive and accessible materials. Validation of the simulator occurred through content and construct validation. Content validation involved subjective assessments by novices and experts, construct validation compared pre‐training novices with experts. Training validation compared pre and post training novices for improvement.ResultsOur findings indicate that users found the simulator useful, realistic, and satisfactory. We found significant differences in tourniquet application skills between pre‐training novices and experts. When comparing pre‐ and post‐training novices, we found a significantly lower bleeding control time between the groups.ConclusionThis study suggests that this training approach can enhance access to life‐saving skills for prehospital personnel. The inclusion of self‐assessment components enables self‐regulated learning and reduces the need for continuous instructor presence. Future improvements involve refining the tourniquet model, validating it with first‐responder end users, and expanding the training program to include other skills.
Diagnostic value of dual-source, dual-energy computed tomography combined with the neutrophil-lymphocyte ratio for discriminating gastric signet ring cell from mixed signet ring cell and non-signet ring cell carcinomas
Authors: Song Qinxia , Wang Xiangfa , Zhu Juan , Shi Hengfeng 
Published: March 2024

Abstract
Purpose
To explore the diagnostic value of dual-source computed tomography (DSCT) and neutrophil to lymphocyte ratio (NLR) for differentiating gastric signet ring cell carcinoma (SRC) from mixed SRC (mSRC) and non-SRC (nSRC).

Methods
This retrospective study included patients with gastric adenocarcinoma who underwent DSCT between August 2019 and June 2021 at our Hospital. The iodine concentration in the venous phase (ICvp), standardized iodine concentration (NICVP), and the slope of the energy spectrum curve (kVP) were extracted from DSCT data. NLR was determined from laboratory results. DSCT (including ICVP, NICVP, and kVP) and combination (including DSCT model and NLR) models were established based on the multinomial logistic regression analysis. The receiver operator characteristic (ROC) curve and area under the curve (AUC) were used to evaluate the diagnostic value.

Results
A total of 155 patients (SRC [n = 45, aged 61.22 ± 11.4 years], mSRC [n = 60, aged 61.09 ± 12.7 years], and nSRC [n = 50, aged 67.66 ± 8.76 years]) were included. There were significant differences in NLR, ICVP, NICVP, and kVP among the SRC, mSRC, and nSRC groups (all P < 0.001). The AUC of the combination model for SRC vs. mSRC + nSRC was 0.964 (95% CI: 0.923-1.000), with a sensitivity of 98.3% and a specificity of 86.7%, higher than with DSCT (AUC: 0.959, 95% CI: 0.919–0.998, sensitivity: 90.0%, specificity: 89.9%) or NLR (AUC: 0.670, 95% CI: 0.577–0.768, sensitivity: 62.2%, specificity: 61.8%).

Conclusion
DSCT combined with NLR showed high diagnostic efficacy in differentiating SRC from mSRC and nSRC.
Global longitudinal strain in long-term risk prediction after acute coronary syndrome: an investigation of added prognostic value to ejection fraction
Authors: Lenell Joel , Lindahl Bertil , Erlinge David , Jernberg Tomas , Spaak Jonas , Baron Tomasz 
Published: March 2024

Abstract
Aims
This study aimed to investigate the additional value of global longitudinal strain (GLS) on top of left ventricular ejection fraction (LVEF) in long-term risk prediction of combined death and heart failure (HF) re-hospitalization after acute coronary syndrome (ACS).

Method and results
This retrospective study included patients admitted with ACS between 2008 and 2014 from the three participating university hospitals. LVEF and GLS were assessed at a core lab from images acquired during the index hospital stay. Their prognostic value was studied with the Cox proportional hazards model (median follow-up 6.2 years). A nested model comparison was performed with C-statistics.
A total of 941 patients qualified for multivariable analysis after multiple imputation of missing baseline covariables. The combined outcome was reached in 17.7% of the cases. Both GLS and LVEF were independent predictors of the combined outcome, hazard ratio (HR) 1.068 (95% CI 1.017–1.121) and HR 0.980 (95% CI 0.962–0.998), respectively. The C-statistic increased from 0.742 (95% CI 0.702–0.783) to 0.749 (95% CI 0.709–0.789) (P = 0.693) when GLS entered the model with clinical data and LVEF.

Conclusion
GLS emerged as an independent long-term risk predictor of all-cause death and HF re-hospitalization. However, there was no significant incremental predictive value of GLS when LVEF was already known.

Graphical Abstract
White matter associations with spelling performance
Authors: Sagi Romi , Taylor J. S. H. , Neophytou Kyriaki , Cohen Tamar , Rapp Brenda , Rastle Kathleen , Ben-Shachar Michal 
Published: March 2024

AbstractMultiple neurocognitive processes are involved in the highly complex task of producing written words. Yet, little is known about the neural pathways that support spelling in healthy adults. We assessed the associations between performance on a difficult spelling-to-dictation task and microstructural properties of language-related white matter pathways, in a sample of 73 native English-speaking neurotypical adults. Participants completed a diffusion magnetic resonance imaging scan and a cognitive assessment battery. Using constrained spherical deconvolution modeling and probabilistic tractography, we reconstructed dorsal and ventral white matter tracts of interest, bilaterally, in individual participants. Spelling associations were found in both dorsal and ventral stream pathways. In high-performing spellers, spelling scores significantly correlated with fractional anisotropy (FA) within the left inferior longitudinal fasciculus, a ventral stream pathway. In low-performing spellers, spelling scores significantly correlated with FA within the third branch of the right superior longitudinal fasciculus, a dorsal pathway. An automated analysis of spelling errors revealed that high- and low- performing spellers also differed in their error patterns, diverging primarily in terms of the orthographic distance between their errors and the correct spelling, compared to the phonological plausibility of their spelling responses. The results demonstrate the complexity of the neurocognitive architecture of spelling. The distinct white matter associations and error patterns detected in low- and high- performing spellers suggest that they rely on different cognitive processes, such that high-performing spellers rely more on lexical-orthographic representations, while low-performing spellers rely more on phoneme-to-grapheme conversion.
A study of membrane correction accounting for both curvature and tension in DEM simulations of triaxial tests of sand and ballast with two alternative flexible membrane models
Authors: Tolomeo Mathias , McDowell Glenn R. 
Published: March 2024

AbstractIn DEM simulations of triaxial tests, modelling a flexible lateral membrane is crucial and challenging. It is essential for the correct application of a uniform lateral pressure and for an accurate measurement of sample volume. Here, we introduce a membrane made of triangular facets, and model it as a continuum; we then compare this approach with a well-established method that uses a layer of bonded spheres. With either method, it is also possible to assess the additional stress applied by the membrane as it deforms, i.e. the difference between the stress applied at the boundary and the actual stress within the sample. It is shown that this difference has two origins: the tension developed in the membrane, as it deforms; and the curvature of the membrane, since this causes a vertical component of the confining pressure which can be significant. These findings may be used to inform and improve the membrane correction commonly used in experiments, where similar effects occur.
Graphic abstract
Transforming the food system in ‘unprotected space’: the case of diverse grain networks in England
Authors: Walton Stephanie 
Published: March 2024

AbstractTransitioning to food systems that are equitable, resilient, healthy and environmentally sustainable will require the cultivation and diffusion of transformational sociotechnical innovations—and grassroots movements are an essential source of such innovations. Within the literature on strategic niche management, government-provided ‘protected spaces’ where niche innovations can develop without facing the pressures of the market is an essential part of sustainability transitions. However, because of their desire to transform rather than transition food systems, grassroots movements often struggle to acquire such protected spaces and so must determine how and where to generate change whilst being marginalised and exposed to unprotected spaces. The aim of this research is to gain a precise view of the multiple touchpoints of marginalisation that exist across the grassroots-government interface and to apply a new framework for conceptual analysis of these touchpoints that can help to identify where and how grassroots movements might be able to push against this marginalisation. The study finds that, by applying a ‘who, what, where’ framework of analysis to policies across this interface, it is possible to find pathways forward for achieving small wins towards food systems transformation.
Relationships between ground motion parameters and energy demands for regular low-rise RC frame buildings
Authors: Meral Emrah 
Published: March 2024

AbstractThe present study aims to analyze the correlation between ground motion parameters and energy demands of low-rise RC buildings without shear walls. Two regular 4- and 7-story residential buildings were seismically designed to represent low-rise RC buildings. In order to establish the requirements of single degree of freedom (SDOF) systems as well as multi degree of freedom (MDOF) systems, the dynamic features of “equivalent” SDOF systems were defined by using MDOF systems. The correlation of 20 ground motion parameters (GMPs) of 44 records with the energy demands obtained from a total of 176 nonlinear time history analyses was examined for the SDOF and MDOF systems within the scope of this study. The ground motion parameters (GMPs) were taken as intensity measures (IMs). In contrast, maximum input energy was used as a demand measure (DM) and these energy values were normalized with the masses of the buildings for cases, where the buildings were evaluated together. Parameters related to acceleration and velocity are generally found to yield better results in comparison to the ones related to frequency and displacement. Velocity Spectrum Intensity (VSI) and Arias Intensity (Ia) were obtained to have the highest correlation values as a single parameter. This study suggested new equations by combining multiple ground motion parameters for SDOF and MDOF systems to better reflect damage potential than a single parameter. The use of multiple parameters in combination results in better correlation coefficients.
Surveys that prioritize site number over time per site will result in better gastropod status assessments: a case study on the rediscovery of Big Black Rocksnail
Authors: Rezac Calvin R. , Ellwanger Robert J. , Donohoo Samantha A. , Hartfield Paul D. , Ruppel Ashley S. , Ruppel David S. , Wagner Matthew D. , Whelan Nathan V. 
Published: March 2024

AbstractFreshwater gastropods are among the most imperiled organisms on Earth. Yet, they are among the most understudied freshwater taxa. Numerous freshwater gastropod species have gone extinct in the last 100 years, but recent rediscoveries indicate that some species were prematurely declared extinct. Such premature extinction declarations remove legal protections, which could facilitate actual extinction. Thus, research and policy recommendations are needed so surveys provide the best information possible for conservation. Here, we examined the case of Lithasia hubrichti, a freshwater gastropod endemic to the Big Black River in Mississippi that was last seen in 1965. In 2022, a freshwater mollusk survey resulted in finding L. hubrichti alive. An additional survey effort in 2023 that prioritized sampling as many sites as possible in a single day clarified the current range of L. hubrichti. Genomic analyses indicated that the species has persisted with a large population size for thousands of years, rather than ever falling below a survey detection limit. When considering the case of L. hubrichti and other recent freshwater gastropod rediscoveries, we conclude that freshwater gastropod surveys should emphasize sampling as many sites as possible under favorable sampling conditions when targeting rare species, rather than expending high sampling effort at a small number of sites or when stream conditions may impact ability to detect target species. We also advocate for policies that encourage partnerships with landowners, which was required to rediscover L. hubrichti.
Comparison of long-term oncologic outcomes of central lumpectomy and conventional breast-conserving surgery for invasive breast cancer: propensity score matching analysis
Authors: Jung Ji-Jung , Cheun Jong-Ho , Kim Hong-Kyu , Lee Han-Byoel , Moon Hyeong-Gon , Hwang Ki-Tae , Han Wonshik 
Published: March 2024

Abstract
Purpose
Central lumpectomy (CL) is a breast-conserving surgical (BCS) technique that involves excision of the nipple-areolar complex with breast tumor in centrally located breast cancers. We aimed to investigate the long-term clinical outcomes of CL in comparison with conventional BCS (cBCS).

Methods
Patient records who underwent BCS with clear resection margins for invasive breast cancer between 2004 and 2018 were retrospectively reviewed. Of the total 6,533 patients, 106 (1.6%) underwent CL. Median follow-up duration was 73.4 months. 1:3 propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to minimize selection bias.

Results
The CL group showed a significantly higher ipsilateral breast tumor recurrence (IBTR) rate than the cBCS group (10-year IBTR rate: 5.8% vs. 3.1%, p = 0.004), even after adjusting for other variables (hazard ratio (HR), 2.65; 95% confidence interval (CI), 1.07–6.60, p = 0.048). However, there were no significant differences observed in regional recurrence, distant metastasis, or overall survival rates between the two groups. Both PSM and IPTW analyses showed significantly higher IBTR in the CL group (PSM HR, 3.27; 95% CI, 0.94–11.36; p = 0.048 and IPTW HR, 4.66; 95%CI, 1.85–11.77; p < 0.001). Lastly, when analyzing 2,213 patients whose tumors were located within 3 cm of the nipple, the CL group showed a significantly higher IBTR than the cBCS group before and after PSM.

Conclusion
CL was associated with a higher rate of IBTR compared to cBCS, while other survival outcomes were comparable. For centrally located tumors, CL may be considered for patients preferring breast preservation. However, higher risk for IBTR should be informed and careful surveillance may be necessary during the early post-operative follow-up periods.
Flax biorefining for paper production
Authors: Cabañas-Romero L. Verónica , Cusola Oriol , Buruaga-Ramiro Carolina , Valls Cristina , Roncero M. Blanca , Valenzuela Susana V. 
Published: March 2024

AbstractIn this work, we assessed the potential of Cel6D, a recently reported exocellulase from Paenibacillus barcinonensis, as a biorefining agent for flax pulp. Pulp fibers were treated with this enzyme, Cel9B (an endocellulase previously shown to possess biorefining action) and the two in combination. Samples of biorefined flax pulp were mechanically refined to obtain handsheets. All three biorefining treatments decreased air permeance in the handsheets. Cel9B increased tensile index and folding endurance, and the Cel6D − Cel9B combination increased tensile index and burst index but also resulted in markedly decreased tear index and folding endurance. On the other hand, Cel6D increased tensile index and burst index; also, more importantly, it increased tear resistance, albeit slightly, relative to the other two treatments. The results of this work can be useful to understand the differential effects of exocellulases and endocellulases as biorefining tools and open up new avenues for exploring their use in other biotechnological applications.
Quantum software engineering and quantum software development lifecycle: a survey
Authors: Dwivedi Kanishk , Haghparast Majid , Mikkonen Tommi 
Published: March 2024

AbstractQuantum software engineering is advancing in the domain of quantum computing research and application, yet the documentation is scattered. The slow transition from Von-Neumann based computation systems to quantum systems, and conserving the fundamental computing principles in software development and software engineering helps in enrichment of quantum software development. The evolution of quantum computing over the past years shows a shift in the domain of classical computation to quantum computation in the years to come. Future applications such as, quantum AI and quantum machine learning will benefit from quantum software engineering. This survey collects and explores the various documentations in the domain of quantum systems and quantum software engineering. The survey provides an in-depth exploration of quantum programming languages, which is combined with explanations of quantum computing’s fundamentals. The review also goes in-depth about quantum software engineering and quantum software life cycle development, outlining the quantum software reuse methodology that is introduced in the quantum software lifecycle development domain.
A Crash Course in Differential Games and Applications
Authors: de Zeeuw Aart 
Published: March 2024

AbstractThe methodology of differential games is a combination of optimal control theory and game theory. It is the natural framework for economic analysis with strategic interaction and dynamical optimization. The theory gained traction by seminal papers in the early seventies, and it gradually found its way into economics. The purpose of this paper is to make theory and applications of differential games easily accessible by explaining the basics and by developing some characteristic applications. The core of the theory focuses on the open-loop and the multiple Markov-perfect Nash equilibria that use the maximum principle and dynamic programming as the techniques to solve the optimal control problems. The applications are the game of international pollution control and the game of managing a lake, which is an example of an ecological system with tipping points. Finally, it is interesting to note that the discovery of time-inconsistency in the open-loop Stackelberg equilibrium had a huge impact on macroeconomics, since policy making under rational expectations is a Stackelberg differential game.
Draft genome and SSR data mining of a Peruvian landrace of Capsicum chinense, the arnaucho chili pepper
Authors: Estrada Richard , Tantalean Jose F. C. , Saldaña Carla L. , Romero Yolanda , Vilcara Edgardo , Arbizu Carlos I. 
Published: March 2024

AbstractThe Arnaucho chili pepper (ACP) is a traditional vegetable used in Peru because of its gastronomic properties. Due to its importance in the Peruvian diet and economy, this species is a resource that can be a candidate to plant breeding programs. In this study, the complete genome nucleotide sequence of this chili pepper was generated using the Illumina Hiseq 2500 sequencing technology. We sequenced the whole genome of the ACP using a paired-end 150 strategy, obtaining 330.46 GB of sequencing data. The genome size of the ACP was 2.98 Gb with a contig N50 of 237 Mb and 95.39% complete BUSCOs. Also, we identified 71.96% of repetitive DNA of the genome assembly, of which retroelements occupy 37.95% of the total genome. We downloaded genomes of the Solanoideae subfamily and conducted a comparative analysis of simple sequence repeats (SSRs) with our draft genome, and we identified lower number of SSRs in the ACP genome compared to other pepper species. This first ACP genome is expected to contribute to a better understanding of its genetics to adapt to the arid conditions of the Peruvian coastal ecosystem and evolution.