bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive role of the dietary phytochemical index in relation to the clinical and psychological traits of migraine headaches
Authors: Amani Tirani Shahnaz , Balali Arghavan , Kazemi Maryam , Askari Gholamreza , Khorvash Fariborz , Arab Arman 
Published: March 2024

AbstractWe investigated the relationship between dietary phytochemical index (DPI) and migraine headaches in Iranian patients, analyzing both clinical and psychological traits. A cross-sectional study was conducted using non-obese adults aged 20–50 years who were diagnosed with migraine. The study used a validated 168-item food frequency questionnaire to assess the usual dietary intake of participants. The DPI was calculated using the following formula: [daily energy derived from phytochemical-rich foods (in kJ)/total daily energy intake (in kJ)] × 100. Clinical outcomes of migraine including frequency, duration, and severity of headaches, as well as migraine-related disability were obtained using relevant questionnaires. Moreover, the mental health profile of patients including depression, anxiety, and stress, as well as serum levels of nitric oxide (NO) were measured. A Poisson regression was used for headache frequency. Linear regression analyzed migraine-related outcomes including duration, severity, migraine-related disability, and serum NO levels. In addition, psychological traits were analyzed via logistic regression. A total of 262 individuals (85.5% females) with a mean age of 36.1 years were included in the analysis. The frequency of migraine attacks was lower in patients in the last DPI tertile compared to those in the first DPI tertile both in the crude [incidence rate ratio (IRR) = 0.70, 95% confidence interval (CI) 0.63, 0.78, Ptrend < 0.001] and fully-adjusted models (IRR = 0.84, 95% CI 0.74, 0.96, Ptrend = 0.009). After controlling for potential confounders, an inverse relationship was observed between higher adherence to DPI and migraine-related disability (β = − 2.48, 95% CI − 4.86, − 0.10, P trend = 0.046). After controlling for potential confounders, no significant relationship was observed between DPI and depression (OR = 0.79, 95% CI 0.42, 1.47, Ptrend = 0.480), anxiety (OR = 1.14, 95% CI 0.61, 2.14, Ptrend = 0.655), and stress (OR = 1.04, 95% CI 0.57, 1.90, Ptrend = 0.876). Higher intakes of phytochemical-rich foods may be associated with lower migraine frequency and improved daily activities among patients. Further studies should confirm our observations and delineate the biological pathways linking phytochemicals and migraine headaches.
Impact of COVID-19 on quality of life in survivors with pulmonary sequelae
Authors: Rodríguez-Galán Irene , Albaladejo-Blázquez Natalia , Ruiz-Robledillo Nicolás , Pascual-Lledó José Francisco , Ferrer-Cascales Rosario , Gil-Carbonell Juan 
Published: March 2024

AbstractSARS-CoV-2 respiratory infection is still under study today, mainly because of its long-term effects. This study aims to analyse health status and health-related quality of life (HRQoL) in survivors of coronavirus pneumonia (COVID-19) who have developed pulmonary sequelae. Prospective observational study of patients diagnosed with COVID-19 pneumonia between February and May 2020. Reviews were conducted at 3 and 12 months after hospital discharge. HRQoL was assessed by administration of the SF-36 questionnaire and data related to medical records and physical examination were also collected. In addition, chest X-ray, computed tomography and pulmonary function test were included as additional tests. 305 patients were admitted for COVID-19 pneumonia of which 130 (42.6%) completed follow-up. The mean age of the enrolled group was 55.9 ± 15.9 years. The most prevalent persistent symptoms were dyspnea (37.3%) and asthenia (36.9%). Pulmonary sequelae were detected in 20.8% of participants. The most frequent alteration was ground ground glass opacities (GGO) (88.9%), with mild extension. Fibrotic changes were found in only 2% of cases. When comparing the two groups, at 3 and 12 months of evolution, lower scores in the vitality (VT) and mental health (MH) domains were found only in the group without sequelae. Days of hospitalisation and Charlson index acted as influential factors on HRQoL. Minimal or mild pulmonary sequelae of SARS-CoV-2 do not cause further deterioration of HRQoL. Repeated medical care and pulmonary rehabilitation are effective tools to improve HRQoL.
Comparison of ultrasonography-based masticatory muscle thickness between temporomandibular disorders bruxers and temporomandibular disorders non-bruxers
Authors: Lee Yeon-Hee , Chun Yang-Hyun , Bae Hyungkyu , Lee Jung-Woo , Kim Hee-Jin 
Published: March 2024

AbstractTo compare masticatory muscle thickness in patients with temporomandibular disorders (TMDs) during rest and clenching, and by body position, using ultrasonography. This prospective study included 96 patients with TMD (67 females, 29 males; mean age: 40.41 ± 17.88 years): group 1, comprising 66 patients with TMD without bruxism (TMD_nonbruxer), and group 2, comprising 30 patients with concurrent TMD and bruxism (TMD_bruxer). In patients with TMD, bruxism was correlated with the presence of tinnitus, muscle stiffness, sleep problems, psychological stress, and restricted mouth opening. The masseter muscle significantly thickened during clenching (11.16 ± 3.03 mm vs 14.04 ± 3.47 mm, p < 0.001), whereas the temporalis muscle showed no significant increase in thickness from resting to clenching in an upright position (7.91 ± 1.98 vs 8.39 ± 2.08, p = 0.103). Similarly, during clenching in the supine position, the masseter muscle was significantly thicker compared with rest (11.24 ± 2.42 vs 13.49 ± 3.09, p < 0.001), but no significant difference was observed in temporal muscle thickness (8.21 ± 2.16 vs 8.43 ± 1.94, p = 0.464). In comparison between two groups, the average thickness of the masseter muscle was greater among TMD_bruxers than among TMD_nonbruxers in both the upright and supine positions (all p < 0.05). In the generalized lineal model, female sex (B = − 1.018, 95% confidence interval [CI] − 1.855 to − 0.181, p = 0.017) and bruxism (B = 0.868, 95% CI 0.567 to 1.169, p = 0.048) significantly predicted changes in masseter muscle thickness. Female sex (B = − 0.201, 95% CI − 0.299 to − 0.103, p = 0.011), increased age (B = − 0.003, 95% CI − 0.005 to 0.000, p = 0.038), and muscle stiffness (B = − 1.373, 95% CI − 2.369 to − 0.376, p = 0.007) were linked to decreased temporal muscle thickness. Comparing TMD nonbruxer and bruxer muscle thicknesses in upright and supine positions revealed significant increased thickness in the masseter muscle during clenching but not in the temporalis muscle. Masseter muscle thickness varied significantly by sex, body position, and resting/clenching, notably influenced by bruxism. These findings emphasize the relevance of these factors in clinical examinations of patients with TMD.
A global meta-analysis of ecological effects from offshore marine artificial structures
Authors: Lemasson Anaëlle J. , Somerfield Paul J. , Schratzberger Michaela , Thompson Murray S. A. , Firth Louise B. , Couce Elena , McNeill C. Louise , Nunes Joana , Pascoe Christine , Watson Stephen C. L. , Knights Antony M. 
Published: March 2024

AbstractMarine artificial structures (MAS), including oil and gas installations (O&G) and offshore wind farms (OWFs), have a finite operational period. Selecting the most suitable decommissioning options when reaching end-of-life remains a challenge, in part because their effects are still largely undetermined. Whether decommissioned structures could act (sensu ‘function’) as artificial reefs (ARs) and provide desired ecological benefits is of particular interest. Here we use a meta-analysis approach of 531 effect sizes from 109 articles to assess the ecological effects of MAS, comparing O&G and OWFs to shipwrecks and ARs, with a view to inform their decommissioning. This synthesis demonstrates that while MAS can bring ecological benefits, important idiosyncrasies exist, with differences emerging between MAS types, habitat types, taxa and ecological metrics. Notably, we find limited conclusive evidence that O&G and OWFs would provide significant ecological benefits if decommissioned as ARs. We conclude that decommissioning options aimed at repurposing MAS into ARs may not provide the intended benefits.
Agri-environmental policies from 1960 to 2022
Authors: Wuepper David , Wiebecke Ilsabe , Meier Lara , Vogelsanger Sarah , Bramato Selina , Fürholz Andrea , Finger Robert 
Published: March 2024

AbstractFor both research and practice, it is paramount to understand what, where and when agri-environmental policies have been put in place. Here we present a database of 6,124 agri-environmental policies implemented between 1960 and 2022 in about 200 countries. The database comprises a wide range of policy types (including regulations and payment schemes) and goals (such as biodiversity conservation, safer pesticide use and reducing nutrient pollution). We illustrate the application of the database by exploring the association between economic development and agri-environmental policies and between the soil-related, agri-environmental policies of countries and their border discontinuities in cropland erosion. A strong, positive link between economic development and implemented agri-environmental policies is revealed, and it is found that 43% of all global border discontinuities in soil erosion between countries can be explained by differences in their policies.
A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation
Authors: Robitaille Karine , Guertin Marie-Hélène , Jamshidi Afshin , Xu Hui Wen , Hovington Hélène , Pelletier Jean-François , Beaudoin Lisanne , Gevariya Nikunj , Lacombe Louis , Tiguert Rabi , Caumartin Yves , Dujardin Thierry , Toren Paul , Lodde Michele , Racine Étienne , Trudel Dominique , Perigny Martine , Duchesne Thierry , Savard Josée , Julien Pierre , Fradet Yves , Fradet Vincent 
Published: March 2024

AbstractBackgroundHigh prostate eicosapentaenoic fatty acid (EPA) levels were associated with a significant reduction of upgrading to grade group (GG) ≥ 2 prostate cancer in men under active surveillance. We aimed to evaluate the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation.MethodsA phase II double-blind randomized placebo-controlled trial was conducted in 130 men diagnosed with GG ≥ 2 prostate cancer and undergoing radical prostatectomy between 2015–2017 (Clinicaltrials.gov: NCT02333435). Participants were randomized to receive 3 g daily of either MAG-EPA (n = 65) or placebo (n = 65) for 7 weeks (range 4–10) prior to radical prostatectomy. The primary outcome was the cancer proliferation index quantified by automated image analysis of tumor nuclear Ki-67 expression using standardized prostatectomy tissue microarrays. Additional planned outcomes at surgery are reported including plasma levels of 27 inflammatory cytokines and fatty acid profiles in circulating red blood cells membranes and prostate tissue.ResultsCancer proliferation index measured by Ki-67 expression was not statistically different between the intervention (3.10%) and placebo (2.85%) groups (p = 0.64). In theper protocolanalyses, the adjusted estimated effect of MAG-EPA was greater but remained non-significant. Secondary outcome was the changes in plasma levels of 27 cytokines, of which only IL-7 was higher in MAG-EPA group compared to placebo (p = 0.026). Men randomized to MAG-EPA prior to surgery had four-fold higher EPA levels in prostate tissue compared to those on placebo.ConclusionsThis MAG-EPA intervention did not affect the primary outcome of prostate cancer proliferation according to nuclear Ki-67 expression. More studies are needed to decipher the effects of long-chain omega-3 fatty acid dietary supplementation in men with prostate cancer.
L’immunité entraînée
Authors: Badin Lea , Franc Celya , Gilbert Paul , Magdeleine Jean-Jacques , Martin Lisa , Vernaz Rudy , Arrighi Nicole , Garcia-Sanchez Juan A. 
Published: March 2024

Les étudiants de Polytech Nice Sophia (PNS) en Génie Biologique 5A ont exploré trois projets prometteurs. L’équipe pédagogique qui les a encadrés est composée de Cercina ONESTO et Nicole ARRIGHI, enseignants-chercheurs à PNS, et du trinome Céline PISIBON, Imène KROSSA et Juan GARCIA-SANCHEZ, doctorants et post-doctorants du Centre Méditerranéen de Médecine Moléculaire de Nice.
Dès le début du cursus d’ingénieur, les étudiants suivent un cours d’introduction à la recherche. Plus ils avancent dans le cursus, plus ils se perfectionnent dans l’analyse de l’actualité scientifique de leur spécialité. Dans la mineure Pharmacologie et Biotechnologies, ils cernent les limites d’un traitement, puis ils réfléchissent en équipes à une nouvelle piste thérapeutique. Ainsi, ils anticipent l’innovation en santé, l’imaginent et la créent pour devenir les ingénieurs en santé de demain.
Conservative versus Surgical Approaches in the Treatment of Intracapsular Condylar Fractures: A Retrospective Study
Authors: Qi Jianghong , Deng Ying , Jiang Ling , Lu Yang , Li Wei 
Published: March 2024

AbstractThe diagnosis and management of intracapsular condylar fractures (ICFs) are crucial, and if left untreated, they can cause facial asymmetry, limited mouth opening, and even temporomandibular joint (TMJ) ankylosis, which may affect the physical function and mental health of patients. Various procedures have been described for the ICFs, but there is no consensus on the therapeutic methods. This study aimed to compare the clinical efficacy of conservative and surgical management of ICFs.
2.4 On-DNA C—X (X = N, O, P, S, Se) Bond Forming Reactions
Authors: Hou W. , Yang G. , Xu H. 
Published: March 2024

AbstractHeteroatoms are important components of drug molecules because they can not only modulate bioactivity through hydrogen bonding and dipole interactions, but also adjust drug-like properties. In view of this, the development of new methods for DNA-compatible carbon—heteroatom bond construction has received significant attention. This chapter summarizes the latest progress in on-DNA C—X (X = N, O, P, S, Se) bond construction methods.
2.8 DNA-Encoded Isocyanide Multicomponent Reactions
Authors: Willems S. , Brunschweiger A. 
Published: March 2024

AbstractIsocyanide multicomponent reactions (IMCRs) provide access to a plethora of molecular architectures. Four IMCRs have been translated to a DNA-barcoding strategy involving the use of chemically stabilized DNA barcodes coupled to a controlled-pore glass solid support. These are the Ugi reaction, the Gröbke–Blackburn–Bienaymé reaction, the Ugi-azide reaction, and the Ugi–aza-Wittig reaction. The reactions were all performed using DNA-tagged aldehydes, and provide diverse scaffolds. The DNA used in this barcoding strategy was composed of three nucleobases: thymine, cytosine, and 7-deaza-adenine, as a more depurination-resistant congener of adenine.
Exploring role-playing as a tool for involving citizens in air pollution mitigation urban policies
Authors: Boso Àlex , Garrido Jaime , Sánchez-Galvis Luz Karime , Rodríguez Ignacio , Vallejos-Romero Arturo 
Published: March 2024

AbstractThe design of air pollution control policies is a complex decision-making process. Public participation can enhance the legitimacy and effectiveness of environmental urban regulations but does not always occur naturally. This article presents the experience of the use of role-playing in six mid-sized cities in southern Chile to evaluate how residents affected by high concentrations of fine particulate matter perceive the problem and debate possible solutions. For this, the participants were asked to assume the role of advisors. On that premise, they had to prioritize between a series of mitigation measures and reach a consensus with other advisors. The results show the potential of role-playing games, on the one hand, to promote critical thinking and argument skills among the general public and, on the other, to help policymakers in the design of more operative and fair plans of action.
Tunable and stable micro-ring resonator based on thin-film lithium tantalate
Authors: Yu Jiayang , Ruan Ziliang , Xue Yu , Wang Haohua , Gan Ranfeng , Gao Tian , Guo Changjian , Chen Kaixuan , Ou Xin , Liu Liu 
Published: March 2024

As ferroelectric materials, lithium tantalate and lithium niobate share similar material characteristics, such as a high Pockels effect and nonlinear optical coefficients. When compared to lithium niobate, lithium tantalate offers a higher optical damage threshold, a broader transparent window, and lower birefringence, making it a promising candidate for high-performance electro-optical photonic integrated devices. In this study, we design and successfully fabricate micro-ring resonators on an acoustic-grade lithium-tantalate-on-insulator wafer, demonstrating their tunability and dynamic modulation capabilities. Experimental results indicate that the achieved thin-film lithium tantalate based micro-ring resonator exhibits an intrinsic Q-factor of 8.4 × 105, corresponding to a waveguide propagation loss of 0.47 dB/cm and a tuning efficiency of 1.94 pm/V. More importantly, as compared to those based on thin-film lithium niobate, a much weaker photorefractive effect and drift phenomenon around the 1550 nm wavelength under a direct-current drive are observed in the present fabricated thin-film lithium tantalate micro-rings with a silicon oxide over-cladding and a tuning electrode on top.
Exceptional points unveiling quantum limit of fluorescence rates in non-Hermitian plexcitonic single-photon sources
Authors: Zhou Wenjie , Liu Jingfeng , Zhu Juanfeng , Gromyko Dmitrii , Qiu Chengwei , Wu Lin 
Published: March 2024

Single-photon sources based on plexcitonic systems are notable for their fast fluorescence rates, typically &gt;100 GHz. Our investigations reveal that exceptional points (EPs) may unveil the quantum limit of fluorescence rates in plexcitonic single-photon sources. By employing a non-Hermitian Hamiltonian framework and field quantization model, we demonstrate how the fluorescence rate can be ingeniously designed in an exemplified plexcitonic system consisting of a nanocube-on-mirror cavity and a single quantum emitter. We predict the highest fluorescence rates of 11.0, 13.9, and 14.7 THz at the EPs with typical dipole moments of 25, 30, and 35 D, respectively.
Engineering Mn3Ga/GaAs interfaces: a first-principles study on energetic stability and magnetic anisotropy
Authors: Wang Xiaoche , Yang Kesong 
Published: March 2024

Abstract
Mn3Ga-based ferrimagnets have emerged as a promising platform for energy-efficient spintronics. However, the challenge of identifying an appropriate substrate with minimal lattice misfit for the growth of high-quality Mn3Ga films while achieving the desired interfacial magnetic properties persists. Here we investigate the interfacial energetic stability and magnetic anisotropy at the Mn3Ga/GaAs interface through first-principles electronic structure calculations. Four types of interface models based on different configurations, including MnMn/As, MnMn/Ga, MnGa/As, and MnGa/Ga, are systematically examined. Our findings reveal that the MnGa/Ga interface exhibits the largest perpendicular magnetic anisotropy (PMA) but is energetically the least favorable. Conversely, the MnMn/As interface is energetically the most favorable but demonstrates a lower interfacial PMA. Our calculations align well with the experimentally observed formation of the secondary phase Mn2As. This study deepens our understanding of the interfacial properties in Mn3Ga/GaAs and offers some insights for their optimization through strategic interfacial engineering.
Long range piezoelectricity effects in van der Waals heterobilayer systems beyond 1000 atoms
Authors: Hsiao Han-Wei , Narendra Namita , Kubis Tillmann 
Published: March 2024

Abstract
Twist angle is a relevant design and control component for the piezoelectric coefficients of van der Waals (vdW) heterostructures. This theoretical work assesses in high detail the impact of the twist angle on the piezoelectricity of two-dimensional (2D) heterobilayer systems. We expand the density-functional based tight-binding method to predict the piezoelectric coefficients of twisted and corrugated 2D heterobilayer structures with more than 1000 atoms. We showcase the method on hexagonal III–V/transition metal dichalcogenide vdW heterosystems. Our calculations yield a periodic relationship between the in-plane piezoelectric coefficients and the corresponding twist angles, indicating the tunability of the in-plane piezoelectricity. In contrast, the out-of-plane piezoelectricity is not twist angle dependent, but nonlinearly changes with the average interlayer distance.
Predicting ion cyclotron emission from neutral beam heated plasmas in Wendelstein7-X stellarator
Authors: Samant O. , Dendy R.O. , Chapman S.C. , Moseev D. , Ochoukov R. 
Published: March 2024

Abstract
Measurements of ion cyclotron emission (ICE) are planned for magnetically confined fusion plasmas heated by neutral beam injection (NBI) in the Wendelstein 7-X stellarator (W7-X). Freshly injected NBI ions in the edge region, whose velocity-space distribution function approximates a delta-function, are potentially unstable against the magnetoacoustic cyclotron instability (MCI), which could drive a detectable ICE signal. Prediction of ICE from NBI protons in W7-X hydrogen plasmas is challenging, owing to the low ratio of the ions’ perpendicular velocity to the local Alfvén speed,

v

⊥
(
NBI
)

/

V
A

≃
0.14

. We address this from first principles, using the particle-in-cell kinetic code EPOCH. This self-consistently solves the Lorentz force equation and Maxwell’s equations for tens of millions of computational ions (both thermal majority and energetic NBI minority) and electrons, fully resolving gyromotion and hence capturing the cyclotron resonant phenomenology which gives rise to ICE. Our simulations predict an ICE signal which is predominantly electrostatic while incorporating a significant electromagnetic component. Its frequency power spectrum reflects novel MCI physics, reported here for the first time. The NBI ions relaxing under the MCI first drive broadband field energy at frequencies a little below the lower hybrid frequency

ω
LH

,

across the wavenumber range

k

ω

c

/

V
A

=
40

–60, where ω

c
and VA
denote ion cyclotron frequency and Alfvén velocity. Nonlinear coupling between these waves then excites spectrally structured ICE with narrow peaks, at much lower frequencies, typically the proton cyclotron frequency and its lower harmonics. The relative strength of these peaks depends on the specifics of the NBI ion velocity-space distribution and of the local plasma conditions, implying diagnostic potential for the predicted ICE signal from W7-X.
Synergistic effects of calcium silicate/zinc silicate dual compounds and in-situ interconnected pores on promoting bone regeneration of composite scaffolds
Authors: Qian Guowen , Wu Tingting , Wang Zhaozhen , Yu Bo , Ye Jiandong 
Published: March 2024

Abstract
Rapid bone regeneration in implants is important for successful transplantation. In this regard, we report the development of calcium silicate/zinc silicate (CS/ZS) dual-compound-incorporated calcium phosphate cement (CPC) scaffolds with a three-dimensional poly (lactic-co-glycolic acid) network that synergistically promote bone regeneration. In vitro results demonstrated that the incorporation of CS/ZS dual compounds into the CPC significantly promoted the osteogenic differentiation of stem cells compared to the addition of CS or ZS alone. Moreover, the bone-regeneration efficacy of the composite scaffolds was validated by filling in femur condyle defects in rabbits, which showed that the scaffolds with CS and ZS possessed a great bone repair effect, as evidenced by more new bone formation and a faster scaffold biodegradation compared to the scaffold with CS alone.