bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of and period polynomial relations
Authors: Charlton Steven , Keilthy Adam 
Published: April 2024

Abstract
In studying the depth filtration on multiple zeta values, difficulties quickly arise due to a disparity between it and the coradical filtration [9]. In particular, there are additional relations in the depth graded algebra coming from period polynomials of cusp forms for

$\operatorname {\mathrm {SL}}_2({\mathbb {Z}})$

. In contrast, a simple combinatorial filtration, the block filtration [13, 28] is known to agree with the coradical filtration, and so there is no similar defect in the associated graded. However, via an explicit evaluation of

$\zeta (2,\ldots ,2,4,2,\ldots ,2)$

as a polynomial in double zeta values, we derive these period polynomial relations as a consequence of an intrinsic symmetry of block graded multiple zeta values in block degree 2. In deriving this evaluation, we find a Galois descent of certain alternating double zeta values to classical double zeta values, which we then apply to give an evaluation of the multiple t values [22]

$t(2\ell ,2k)$

in terms of classical double zeta values.
Extensions of the colorful Helly theorem for d-collapsible and d-Leray complexes
Authors: Kim Minki , Lew Alan 
Published: April 2024

Abstract
We present extensions of the colorful Helly theorem for d-collapsible and d-Leray complexes, providing a common generalization to the matroidal versions of the theorem due to Kalai and Meshulam, the ‘very colorful’ Helly theorem introduced by Arocha, Bárány, Bracho, Fabila and Montejano and the ‘semi-intersecting’ colorful Helly theorem proved by Montejano and Karasev.
As an application, we obtain the following extension of Tverberg’s theorem: Let A be a finite set of points in

${\mathbb R}^d$

with

$|A|>(r-1)(d+1)$

. Then, there exist a partition

$A_1,\ldots ,A_r$

of A and a subset

$B\subset A$

of size

$(r-1)(d+1)$

such that

$\cap _{i=1}^r \operatorname {\mathrm {\text {conv}}}( (B\cup \{p\})\cap A_i)\neq \emptyset $

for all

$p\in A\setminus B$

. That is, we obtain a partition of A into r parts that remains a Tverberg partition even after removing all but one arbitrary point from

$A\setminus B$

.
An iridovirus from the Antarctic seaspider Pentanymphon antarcticum (Pycnogonida)
Authors: Bojko Jamie , Maxwell Jamie M. , Burgess Amy L. , Nicado Lance , Federici Brian , Griffiths Huw J. , Allcock Louise 
Published: April 2024

AbstractThe Antarctic seaspider Pentanymphon antarcticum is a benthic species in the Southern Ocean, but little is known about its pathogen profile. In this study, we provide a draft genome for a new iridovirus species that has been identified using metagenomic techniques. The draft genome totals 157 260 bp and encodes 188 protein-coding genes. The virus shows greatest protein similarity to a ‘carnivorous sponge-associated iridovirus’ from a deep-sea sponge host. This study represents the first discovery of a pycnogonid iridovirus and the first iridovirus from the Antarctic region.
Genetic diversity and morpho-physiological assessment of drought tolerance in rapeseed (Brassica napus L.) cultivars
Authors: Motallebinia Sara , Sofalian Omid , Asghari Ali , Rasoulzadeh Ali , Fathi Achachlouei Bahram 
Published: April 2024

AbstractWater deficit is one of the most important abiotic stresses constraining crop production in rapeseed. Understanding the mechanisms of adaptation to this stress is essential for the development and production of drought-tolerant genotypes. For this reason, this research study aims to investigate the importance of genetic diversity in identifying genotypes with a high degree of drought tolerance through assessing effectiveness of inter simple sequence repeat (ISSR) markers on 14 genotypes of rapeseed in a factorial design. Morphological and physiological characteristics were studied after the early stages of growth; in order to evaluate the genetic diversity among genotypes, 18 different ISSR markers were used. A total of 106 clear and scalable loci were amplified, of which 60 bands (56.6%) were polymorphic. The highest polymorphism information content belonged to marker number 9 with the amount of 0.365 (85.7%). Gene variation ranged from 0.081 to 0.365 and the rapeseed genotypes were divided into three groups by cluster analysis (unweighted pair group method with arithmetic mean method). The analysis of molecular variance showed that 70% of the total variation was observed within populations and 30% of this variation occurred among populations. In addition, t-test was used for comparing oil content percentage among different genotypes in control and stress levels. Adriana had the highest amount of seed oil with 36.47%, whereas Karaj 2 had the lowest amount with 27.28 and Cooper had the highest decrease in oil content percentage under stress conditions. Overall, the genotypes Likord, Hyola 401 and Sarigol 32 were identified as the most drought-tolerant.
Challenges in Simulating Prevailing Fog Types Over Urban Region of Delhi
Authors: Parde Avinash N. , Ghude Sachin D. , Dhangar Narendra Gokul , Bhautmage Utkarsh Prakash , Wagh Sandeep , Lonkar Prasanna , Govardhan Gaurav , Kumar Rakesh , Biswas Mrinal , Chen Fei 
Published: April 2024

AbstractAccurately predicting fog is challenging due to interplay of myriad processes in its formation and high spatiotemporal variability. This study compares the performance of the Weather Research and Forecasting model with control (CNTL‐WRF) and assimilated fine‐grid (HRLDAS‐WRF) soil fields in the Ingo‐Gangetic Plain (IGP) over a 2‐years winter period (2019–2020 and 2020–2021). Results show HRLDAS‐WRF enhances accuracy in representing surface fog's heterogeneity and lifecycle across the IGP, demonstrating a spatial skill improvement of approximately 18% with a Fraction Skill Score of 0.44, compared to CNTL‐WRF's (0.36). Employing fog classification algorithm identifies 25 dense fog episodes (Vis < 500 m) over Delhi's urban boundary layer, including 14 radiation (RAD), 5 cloud‐base lowering (CBL), 3 advection + radiation (ADV + RAD), and 3 evaporation (EVA) episodes. CNTL‐WRF predicts 20 episodes but misses five due to a dry bias in the initial moisture conditions. However, HRLDAS‐WRF demonstrates limited vertical fog growth in various occurrences, highlighting the crucial role of fine‐gridded soil states for enhanced land‐surface feedback. Detailed analysis shows a 40% reduction in mean onset error for RAD fog occurrences in HRLDAS‐WRF when compared to CNTL‐WRF. In CBL fog episodes, both models exhibit significant radiative cooling and inversion before fog onset, leading to inaccurate predictions as RAD fog. Similarly, forecasting the abrupt development of ADV + RAD fog episodes is challenging as models struggle to replicate moisture intrusion over radiatively cooled surfaces in windy conditions. Predicting EVA fog, forms within an hour after sunrise, remains difficult due to the current model parameterization that rapidly dissipates fog soon after sunrise.
Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor
Authors: Gaitonde Supriya A. , Avet Charlotte , de la Fuente Revenga Mario , Blondel-Tepaz Elodie , Shahraki Aida , Pastor Adrian Morales , Talagayev Valerij , Robledo Patricia , Kolb Peter , Selent Jana , González-Maeso Javier , Bouvier Michel 
Published: April 2024

AbstractThe intricate involvement of the serotonin 5-HT2A receptor (5-HT2AR) both in schizophrenia and in the activity of antipsychotic drugs is widely acknowledged. The currently marketed antipsychotic drugs, although effective in managing the symptoms of schizophrenia to a certain extent, are not without their repertoire of serious side effects. There is a need for better therapeutics to treat schizophrenia for which understanding the mechanism of action of the current antipsychotic drugs is imperative. With bioluminescence resonance energy transfer (BRET) assays, we trace the signaling signature of six antipsychotic drugs belonging to three generations at the 5-HT2AR for the entire spectrum of signaling pathways activated by serotonin (5-HT). The antipsychotic drugs display previously unidentified pathway preference at the level of the individual Gα subunits and β-arrestins. In particular, risperidone, clozapine, olanzapine and haloperidol showed G protein-selective inverse agonist activity. In addition, G protein-selective partial agonism was found for aripiprazole and cariprazine. Pathway-specific apparent dissociation constants determined from functional analyses revealed distinct coupling-modulating capacities of the tested antipsychotics at the different 5-HT-activated pathways. Computational analyses of the pharmacological and structural fingerprints support a mechanistically based clustering that recapitulate the clinical classification (typical/first generation, atypical/second generation, third generation) of the antipsychotic drugs. The study provides a new framework to functionally classify antipsychotics that should represent a useful tool for the identification of better and safer neuropsychiatric drugs and allows formulating hypotheses on the links between specific signaling cascades and in the clinical outcomes of the existing drugs.
A multinational survey of potential participant perspectives on ocular gene therapy
Authors: Britten-Jones Alexis Ceecee , McGuinness Myra B. , Chen Fred K. , Grigg John R. , Mack Heather G. , Ayton Lauren N. 
Published: April 2024

AbstractAmidst rapid advancements in ocular gene therapy, understanding patient perspectives is crucial for shaping future treatment choices and research directions. This international cross-sectional survey evaluated knowledge, attitudes, and perceptions of ocular genetic therapies among potential recipients with inherited retinal diseases (IRDs). Survey instruments included the Attitudes to Gene Therapy-Eye (AGT-Eye), EQ-5D-5L, National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25), and Patient Attitudes to Clinical Trials (PACT-22) instruments. This study included 496 participant responses (89% adults with IRDs; 11% parents/guardians/carers) from 35 countries, with most from the United States of America (USA; 69%) and the United Kingdom (11%). Most participants (90%) indicated they would likely accept gene therapy if it was available, despite only 45% agreeing that they had good knowledge of gene therapy. The main sources of information were research registries (60% of participants) and the internet (61%). Compared to data from our recently published Australian national survey of people with IRDs (n = 694), USA respondents had higher knowledge of gene therapy outcomes, and Australian respondents indicated a higher perceived value of gene therapy treatments. Addressing knowledge gaps regarding outcomes and financial implications will be central to ensuring informed consent, promoting shared decision-making, and the eventual clinical adoption of genetic therapies.
Multifunctional carbon nanotubes coated stainless steel mesh for electrowetting, hydrophobic, and dye absorption behavior
Authors: Park Hyeong Kwang Benno , Kebaili Imen , Boukhris Imed , Joo Yun Hwan , Sung Tae Hyun , Kumar Anuruddh 
Published: April 2024

AbstractElectrowetting behaviour for carbon nanotubes (CNT) grown on stainless steel mesh was investigated. The effect of temperature, time, and applied bias voltage on the contact angle of water droplets was studied. The impact of temperature variation on contact angle was also performed for the temperature ranging from 25 to 70 °C. A decrement of contact angle by 68% was observed for the mentioned range indicating a transition from a hydrophobic to hydrophilic nature. A similar trend was observed on the application of electric potential to the CNT-modified stainless-steel mesh ranging from 0 to 8 V with a transition of contact angle from 146 to 30 deg respectively. A comparative analysis for the contact angle variation with time for CNT-coated mesh and uncoated mesh was performed for 180 min. It is observed that uncoated mesh shows a reduction in contact angle to 0 deg with time while the CNT coated mesh shows surplus hydrophobicity with a 2 deg decrement in the extent of time. CNT-modified mesh successfully absorbs 95% of rhodamine B (RB) dye and detergent from water in 10 cycles.
Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates
Authors: Rinne Maiju K. , Urvas Lauri , Mandrika Ilona , Fridmanis Dāvids , Riddy Darren M. , Langmead Christopher J. , Kukkonen Jyrki P. , Xhaard Henri 
Published: April 2024

AbstractTunicates are evolutionary model organisms bridging the gap between vertebrates and invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to vertebrate orexin receptors and protostome allatotropin receptors (ATR). Here, molecular phylogeny suggested that CiOX is divergent from ATRs and human orexin receptors (hOX1/2). However, CiOX appears closer to hOX1/2 than to ATR both in terms of sequence percent identity and in its modelled binding cavity, as suggested by molecular modelling. CiOX was heterologously expressed in a recombinant HEK293 cell system. Human orexins weakly but concentration-dependently activated its Gq signalling (Ca2+ elevation), and the responses were inhibited by the non-selective orexin receptor antagonists TCS 1102 and almorexant, but only weakly by the OX1-selective antagonist SB-334867. Furthermore, the 5-/6-carboxytetramethylrhodamine (TAMRA)-labelled human orexin-A was able to bind to CiOX. Database mining was used to predict a potential endogenous C. intestinalis orexin peptide (Ci-orexin-A). Ci-orexin-A was able to displace TAMRA-orexin-A, but not to induce any calcium response at the CiOX. Consequently, we suggested that the orexin signalling system is conserved in Ciona intestinalis, although the relevant peptide-receptor interaction was not fully elucidated.
Nano round polycrystalline adsorbent of chicken bones origin for Congo red dye adsorption
Authors: Ofudje Edwin Andrew , Al-Ahmary Khairia Mohammed , Alshdoukhi Ibtehaj F. , Alrahili Mazen Rzeeg , Kavil Yasar N. , Alelyani Saeed Saad , Bakheet Ammar M. , Al-Sehemi Abdullah G. 
Published: April 2024

AbstractNano round polycrystalline adsorbent (NRPA) of chicken bones origin was utilize as effective adsorbent in Congo red dye removal via aqueous media. The NRPA adsorbent was prepared via thermal decomposition and its structure was investigated with the aids of Transmission Electron Microscopy, Fourier Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy, Energy Dispersive X-ray Analysis (EDX), and X-ray Diffractometer (XRD). A monophasic apatite phase was confirmed from XRD investigation, while functional groups analysis showed that NRPA possessed CO32−, PO43− and OH− absorption bands. The maximum adsorption capacities derived from Langmuir isotherm is 98.216 mg g−1. From the combined values of n from Freundlich and separation factor (RL) of Langmuir models, the adsorption of CR by NRPA is favourable. Thermodynamic values of 5.280 kJ mol−1 and 16.403 kJ mol−1 K−1 were found for ΔH° and ΔS° respectively. The entire values of ΔG° which ranges from − 35.248 to − 459.68 kJ mol−1 were all negative at different temperatures. Thus, nano polycrystalline adsorbent of chicken bone origin can serve as excellent adsorbent in Congo red dye removal from waste water.
Short-term outcome after treatment of talocrural instability in cats using modified type II transarticular external skeletal fixation
Authors: Gadallah Shaaban , El-Sunsafty Mohamed , Sharshar Ahmed , Misk Tarik , Fischer Carolin , Jaehrig Rodja , Feichtenschlager Christian , Kramer Martin , Hammad Amal 
Published: April 2024

AbstractTransarticular external skeletal fixation (TESF) is repeatedly used for temporary stabilisation of tarsal joint in cats. Hence, this study aimed to evaluate the use of temporary modified type II TESF for management of talocrural instability (TCI) in cats without joint arthrodesis and to rate short-term outcomes and complications. Medical records of all cats treated for TCI between January 2012 and December 2021 were reviewed. Information was collected including signalment, degree of lameness, type of TCI, accompanying soft tissue and bone injuries, and post-operative follow-up assessment including time of frame removal, complications, degree of lameness, range of joint motion and ankylosis. Surgical management didn’t involve debridement of the articular cartilage. Eighty-five percent of cats had satisfactory joint stability at the time of frame removal. Eighteen cats exhibited minor complications, six cats had major complications, and 8 cats showed persistent lameness. All cats showed reduction of joint motion range by 20°–30° directly after frame removal while returned to normal in 79% of cats 4 weeks later. Variable degrees of joint ankylosis were reported. In conclusion, this study supports the use of temporary modified type II TESF for management of TCI in cats without joint involvement as an excellent alternative to tarsal arthrodesis.
Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy
Authors: Hashem Mona M. , Attia Dalia , Hashem Yomna A. , Hendy Moataz S. , AbdelBasset Safa , Adel Farah , Salama Maha M. 
Published: April 2024

AbstractDandruff, a common scalp disorder characterized by flaking dead skin, is often treated with conventional topical products. However, limitations exist due to potential side effects and high costs. Therefore, searching for natural, cost-effective solutions for dandruff and hair loss is crucial. Rosemary herb and neem tree, both cultivated in Egypt, possess well-documented anti-inflammatory properties derived from their rich phenolic phytoconstituents. This study formulated a standardized combined extract of rosemary and neem (RN-E 2:1) into hair gel and leave-in tonic formats. This extract demonstrated superior efficacy against Malassezia furfur (a causative agent of dandruff) and Trichophyton rubrum (associated with scalp disorders) compared to the conventional antifungal agent, ketoconazole. The combined extract (RN-E 2:1) also exhibited potent anti-inflammatory activity. Additionally, the suppression of iNOS expression is considered concentration-dependent. Quality control verified formulation stability, and ex-vivo studies confirmed effective ingredient penetration into the epidermis, the primary site of fungal presence. Remarkably, both formulations outperformed the standard treatment, minoxidil in hair growth trials. These findings highlight the potential of natural extracts for scalp and hair health.
Stable diesel microemulsion using diammonium ionic liquids and their effects on fuel properties, particle size characteristics and combustion calculations
Authors: El Nagy H. A. , Mohamed Mahmoud Abd El-Aziz 
Published: April 2024

AbstractEcofriendly and stable Fuel Microemulsions based on renewable components were prepared through solubilizing ethanol in diesel and waste cooking oil blend (4:1). New diquaternary ammonium ionic liquids (3a & 3b) were synthesized through a quaternization reaction of the synthesized dihaloester with diethyl ethanolamine tridecantrioate and triethyl amine tridecantrioate, respectively. The chemical structures were elucidated by NMR spectroscopy. It was observed from DLS analyses that the ethanol particles in all samples have sizes between 4.77 to 11.22 nm. The distribution becomes narrower with the decrease in the ionic liquid concentrations. The fuel properties fall within the ASTM D975 acceptable specifications and are close to the neat diesel properties. The Cetane index were 53 and 53.5, heating values were 38.5 and 38.5 MJ/kg, viscosities were 2.91 and 2.98 mm2/s, densities were 8.26 and 8.29 g/mL and flash points were 49 °C and 48 °C for 3a1 and 3b1 microemulsions, respectively. The particle sizes of samples were examined by DLS for 160 days and they were significantly stable. The amount of ethanol solubilized increases with the increase in the amount of the synthesized ionic liquids and cosurfactant. The combustion calculations pointed out that the microemulsions 3a1 and 3b1 need 13.07 kg air/kg fuel and 12.79 kg air/kg fuel, respectively, which are less than the air required to combust the pure diesel. According to theoretical combustion, using ionic liquids saves the air consumption required for combustion and reduces the quantities of combustion products. The prepared microemulsions were successfully used as a diesel substitute due to their improved combustion properties than pure diesel and low pollution levels.
Differential gene expression in decidualized human endometrial stromal cells induced by different stimuli
Authors: Doi-Tanaka Yumiko , Tamura Isao , Shiroshita Amon , Fujimura Taishi , Shirafuta Yuichiro , Maekawa Ryo , Taketani Toshiaki , Sato Shun , Sugino Norihiro 
Published: April 2024

AbstractDecidualization can be induced by culturing human endometrial stromal cells (ESCs) with several decidualization stimuli, such as cAMP, medroxyprogesterone acetate (MPA) or Estradiol (E2). However, it has been unclear how decidualized cells induced by different stimuli are different. We compared transcriptomes and cellular functions of decidualized ESCs induced by different stimuli (MPA, E2 + MPA, cAMP, and cAMP + MPA). We also investigated which decidualization stimulus induces a closer in vivo decidualization. Differentially expressed genes (DEGs) and altered cellular functions by each decidualization stimuli were identified by RNA-sequence and gene-ontology analysis. DEGs was about two times higher for stimuli that use cAMP (cAMP and cAMP + MPA) than for stimuli that did not use cAMP (MPA and E2 + MPA). cAMP-using stimuli altered the cellular functions including angiogenesis, inflammation, immune system, and embryo implantation whereas MPA-using stimuli (MPA, E2 + MPA, and cAMP + MPA) altered the cellular functions associated with insulin signaling. A public single-cell RNA-sequence data of the human endometrium was utilized to analyze in vivo decidualization. The altered cellular functions by in vivo decidualization were close to those observed by cAMP + MPA-induced decidualization. In conclusion, decidualized cells induced by different stimuli have different transcriptome and cellular functions. cAMP + MPA may induce a decidualization most closely to in vivo decidualization.
A large non-parasitic population of Savalia savaglia (Bertoloni, 1819) in the Boka Kotorska Bay (Montenegro)
Authors: Canessa Martina , Trainito Egidio , Bavestrello Giorgio , Petović Slavica , Đorđević Nikola , Mačić Vesna 
Published: April 2024

AbstractThe golden coral Savalia savaglia is a long-living ecosystem engineer of Mediterranean circalittoral assemblages, able to induce necrosis of gorgonians’ and black corals’ coenenchyme and grow on their cleaned organic skeleton. Despite its rarity, in Boka Kotorska Bay (Montenegro) a shallow population of more than 1000 colonies was recorded close to underwater freshwater springs, which create very peculiar environmental conditions. In this context, the species was extremely abundant at two sites, while gorgonians were rare. The abundance and size of S. savaglia colonies and the diversity of the entire benthic assemblage were investigated by photographic sampling in a depth range of 0–35 m. Several living fragments of S. savaglia spread on the sea floor and small settled colonies (< 5 cm high) suggested a high incidence of asexual reproduction and a non-parasitic behaviour of this population. This was confirmed by studying thin sections of the basal portion of the trunk where the central core, generally represented by the remains of the gorgonian host skeleton, was lacking. The S. savaglia population of Boka Kotorska Bay forms the unique Mediterranean assemblage of the species deserving the definition of animal forest. Recently, temporary mitigation measures for anthropogenic impact were issued by the Government of Montenegro. Nevertheless, due to the importance of the sites the establishment of a permanent Marine Protected Area is strongly recommended.