bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of the Intervention to Reduce Early Peanut Allergy in Children (iREACH): A practice‐based clinical trial
Authors: Bilaver Lucy A. , Ariza Adolfo J. , Binns Helen J. , Jiang Jialing , Cohn Rich , Sansweet Samantha , Hultquist Haley , Panza Joy Laurienzo , Togias Alkis , Gupta Ruchi S. 
Published: April 2024

AbstractBackgroundIntroducing peanut products early can prevent peanut allergy (PA). The “Addendum guidelines for the prevention of PA in the United States” (PPA guidelines) recommend early introduction of peanut products to low and moderate risk infants and evaluation prior to starting peanut products for infants at high risk for PA (those with severe eczema and/or egg allergy). Rapid adoption of guidelines could aid in lowering the prevalence of PA. The Intervention to Reduce Early (Peanut) Allergy in Children (iREACH) trial was designed to promote PPA guideline adherence by pediatric clinicians.MethodsA two‐arm, cluster‐randomized, controlled clinical trial was designed to measure the effectiveness of an intervention that included clinician education and accompanying clinical decision support tools integrated in electronic health records (EHR) versus standard care. Randomization was at the practice level (n = 30). Primary aims evaluated over an 18‐month trial period assess adherence to the PPA guidelines using EHR documentation at 4‐ and 6‐month well‐child care visits aided by natural language processing. A secondary aim will evaluate the effectiveness in decreasing the incidence of PA by age 2.5 years using EHR documentation and caregiver surveys. The unit of observation for evaluations are individual children with clustering at the practice level.ConclusionApplication of this intervention has the potential to inform the development of strategies to speed implementation of PPA guidelines.
Feeding difficulties in children with food allergies: An EAACI Task Force Report
Authors: Hill Sarah‐Anne , Nurmatov Ulugbek , DunnGalvin Audrey , Reese Imke , Vieira Mario C. , Rommel Natalie , Dupont Christophe , Venter Carina , Cianferoni Antonella , Walsh Joanne , Yonamine Glauce , Beauregard Alexia , Meyer Rosan , Vazquez‐Ortiz Marta 
Published: April 2024

AbstractThe term “feeding difficulties” refers to a spectrum of phenotypes characterized by suboptimal intake of food and/or lack of age‐appropriate eating habits. While it is evident that feeding difficulties are prevalent within healthy children, no consensus has been reached for those with food allergies. The aim of this study was to systematically review all the available literature reporting the prevalence of feeding difficulties within food allergic children. We searched eight international electronic databases for all published studies until June 2022. International experts in the field were also contacted for unpublished and ongoing studies. All publications were screened against pre‐defined eligibility criteria and critically appraised by established instruments. The substantial heterogeneity of included studies precluded meta‐analyses, so narrative synthesis of quantitative data was performed. A total of 2059 abstracts were assessed, out of which 21 underwent full‐text screening and 10 studies met the study criteria. In these, 12 different terms to define feeding difficulties and 11 diagnostic tools were used. Five papers included data of feeding difficulty prevalence in children with food allergies, ranging from 13.6% to 40%. Higher prevalence was associated with multiple food allergies. The current literature suggests that feeding difficulties are prevalent within food allergic children, particularly those with multiple food allergies. However, the heterogeneity of terminologies and diagnostic tools makes drawing conclusions challenging. Consensus guidelines for the diagnosis and management of feeding difficulties within food allergic children and further research on the development and perpetuation of feeding difficulties are needed to appropriately manage such patients.
School physical activity modes on BMI among adolescents with overweight or obesity: The mediation role of participation willingness
Authors: Li Yin , Xiao Yingchen , Li Fengqin , Han Yu , Zhang Xin , Gao Lei 
Published: April 2024

AbstractObjectivesTo analyze the mode of school physical activity, the relationship with obesity, and participation willingness and behavior in the relationship between modes of school physical activity and BMI in students with overweight or obesity.DesignCross‐sectional study.SampleData from the 2014 Physical Fitness and Health Surveillance of Chinese School Students was used, wherein physical measurements and questionnaires of 3476 middle school students were collected.MeasurementsPhysical measurements and questionnaires were completed. Latent profile analysis and mediated effects analysis were conducted using Mplus 8.3 and IBM SPSS 26.0 for data description and statistical analysis.ResultAfter latent profile analysis divided into poor (9.35%), medium (65.16%), and good (25.49%) groups of school physical activity, among junior middle school students, medium (OR = 0.428, 95% CI = 0.259–0.707, p = .001) and good (OR = 0.448, 95% CI = 0.255–0.718, p = .002) groups were positive for controlling overweight. Among students with overweight or obesity, participation willingness mediated the relationship between the mode of school physical activity and BMI, with effect coefficients of −0.120 (95% CI = −0.264 to −0.016) and −0.240 (95% CI = −0.426 to −0.099).ConclusionsSchool physical activity modes have a positive effect only on preventing and controlling overweight in junior middle school students. For middle school students with obesity, weight‐specific measures should be considered for their prevention and control.
Survey of Phyllosticta citricarpa mating type in the São Paulo citrus belt and optimization of in vitro ascospore production
Authors: Brandão Leonardo Aparecido , Pereira Rosana Gonçalves , Moreira Rafaele Regina , Amorim Lilian , Silva Junior Geraldo José 
Published: April 2024

AbstractPhyllosticta citricarpa, the citrus black spot causal agent, requires both mating types, designated as MAT1‐1 and MAT1‐2, to produce ascospores. Mating‐type ratio in some citrus‐growing areas has been characterized but remains little known in the São Paulo (SP) citrus belt, the largest sweet orange producer worldwide. A protocol for in vitro ascospore production was developed recently; however, there are few studies regarding the optimal conditions for their production. Thus, this study aimed to determine the mating‐type ratio in SP and quantify ascospores produced under different conditions in vitro. The mating types were identified by duplex PCR, and ascospore production was assessed in five culture media: potato dextrose agar (PDA), ½ PDA, malt extract agar (MEA), oatmeal agar (OMA) and citrus agar (CA), and at temperatures from 10 to 30°C. The ratio of MAT1‐1 and MAT1‐2 was similar to 1:1. Ascospore production reached peaks of 8.0, 7.0 and 3.0 × 103 ascospores/mL in MEA, PDA and ½ PDA, respectively. There were no ascospores observed in OMA and CA. P. citricarpa ascospores were observed only at 15, 20 and 25°C in PDA, with peaks of up to 2.0 × 103 ascospores/mL at 42, 35 and 21 days, respectively. There were no ascospores observed at 10 and 30°C. Both mating types are similarly distributed in the SP citrus belt, and in vitro ascospore production may be optimized by using MEA at 25°C. These data provide a better understanding of P. citricarpa sexual reproduction and a background for further studies with ascospores.
Transcriptomic analysis of salt‐tolerant and sensitive high‐yield japonica rice (Oryza sativa L.) reveals complicated salt‐tolerant mechanisms
Authors: Liu Xin , Gao Yingbo , Li Rongkai , Zhang Xiaoxiang , Dong Guichun , Zhou Juan , Zhou Yong , Yang Zefeng , Huang Jianye , Dai Qigen , Yao Youli 
Published: April 2024

AbstractDeveloping and cultivating rice varieties is a potent strategy for reclaiming salinity‐affected soils for rice production. Nevertheless, the molecular mechanisms conferring salt tolerance, especially in conventional high‐yield japonica rice varieties, remain obscure. In this study, Zhendao 23309 (ZD23309) exhibited significantly less grain yield reduction under a salt stress gradient than the control variety Wuyunjing 30 (WYJ30). High positive correlations between grain yield and dry matter accumulation at the jointing, heading and maturity stages indicated that early salt tolerance performance is a crucial hallmark for yield formation. After a mild salt stress (85 mM NaCl) of young seedlings, RNA sequencing (RNA‐seq) of shoot and root separately identified a total of 1952 and 3647 differentially expressed genes (DEGs) in ZD23309, and 2114 and 2711 DEGs in WYJ30, respectively. Gene ontology (GO) analysis revealed numerous DEGs in ZD23309 that play pivotal roles in strengthening salt tolerance, encompassing the response to stimulus (GO:0050896) in shoots and nucleoside binding (GO:0001882) in roots. Additionally, distinct expression patterns were observed in a fraction of genes in the two rice varieties under salt stress, corroborating the efficacy of previously reported salt tolerance genes. Our research not only offers fresh insights into the differences in salt stress tolerance among conventional high‐yield rice varieties but also unveils the intricate nature of salt tolerance mechanisms. These findings lay a solid groundwork for deciphering the mechanisms underlying salt tolerance.
The investigation of parameters affecting the treatment of synthetic bilge water by continuous electrooxidation/flotation process
Authors: Akbarzadeh Yazdi Donya , Yilmaz Alper Erdem , Güler Sümeyye , Komesli Okan Tarık 
Published: April 2024

AbstractThis study addresses the pressing issue of bilge water pollution from ships, a highly oily and hazardous wastewater source. The research employs the electrooxidation/flotation process, known for its effectiveness in organic matter removal. Key parameters, such as initial pH, current density and flow rate, were investigated for their impact on the removal of chemical oxygen demand (COD) and oil‐grease (OG) from bilge water. Initial pH showed minimal effects on COD and OG removal, while current density significantly enhanced removal efficiency by influencing anodic electrochemical reactions. Conversely, higher flow rates reduced residence time and lowered removal efficiency. Optimal conditions, with a current density of 10 mA/cm2, pH 7.5 and a flow rate of 20 ml/min, achieved impressive results, removing approximately 80% of COD and 99% of OG from bilge water. These findings highlight the potential of this method for effective bilge water purification.
Taxonomic revision and dissolution of the genus Monachoides (Gastropoda, Stylommatophora)
Authors: Adamcová Tereza , Juřičková Lucie , Proćków Małgorzata , Neubert Eike , Petrusek Adam , Korábek Ondřej 
Published: April 2024

AbstractMonachoides is a genus of medium‐sized European land snails in the family Hygromiidae. Systematics of this family was until recently based on traits of the genital system that were shown to be uninformative, resulting in revisions of classifications at the genus and family levels. Up to six species were recognized in Monachoides lately, but the inclusion of three of these species was questionable. Our phylogenetic analysis and morphological examinations show that the genus includes species previously classified in two different Hygromiidae subfamilies. After transferring three Balkan species to the unrelated genus Xerocampylaea, Monachoides emerged as a group that diversified relatively northerly, at the boundary between the Balkans and Central Europe. One species, Monachoides bacescui, is synonymized here and a previously overlooked one is redescribed, leaving only three valid species in Monachoides as currently understood: M. incarnatus, M. vicinus and M. welebitanus. These can be distinguished from other hygromiid species by their distinctive microsculpture of the shell surface, which also allows for identification of juveniles or fragmented fossil material. However, the clade comprising the three above species was found to also include the two species currently classified in Perforatella. As a result, the two genera are synonymized, with Perforatella having priority.
Oscillations of a Fluid in a Circular Cylinder with Bottom Elevation
Authors: Nesterov S. V. , Kalinichenko V. A. 
Published: April 2024

Abstract
The problem of standing waves in a circular cylindrical vessel with an elevation on the bottom is formulated and numerically solved in the long wave approximation using an accelerated convergence algorithm. As a result of the calculations, the natural frequency of the fundamental wave mode is determined with a high accuracy. To compare the theoretical results, new experimental data on the excitation of standing surface gravity waves in a circular cylindrical vessel with parabolic and conical elevations at the bottom are presented. It is shown that the calculated and measured natural frequencies of the fundamental wave mode in vessels with the profiled bottom coincide between themselves.
Prognostic factors for disease activity in newly diagnosed teriflunomide-treated patients with multiple sclerosis: a nationwide Danish study
Authors: Mahler Mie Reith , Magyari Melinda , Pontieri Luigi , Elberling Frederik , Holm Rolf Pringler , Weglewski Arkadiusz , Poulsen Mai Bang , Storr Lars Kristian , Bekyarov Plamen Anzhelov , Illes Zsolt , Kant Matthias , Sejbaek Tobias , Stilund Morten Leif , Rasmussen Peter V , Brask Maria , Urbonaviciute Inga , Sellebjerg Finn 
Published: April 2024

BackgroundClinicians frequently rely on relapse counts, T2 MRI lesion load (T2L) and Expanded Disability Status Scale (EDSS) scores to guide treatment decisions for individuals diagnosed with multiple sclerosis (MS). This study evaluates how these factors, along with age and sex, influence prognosis during treatment with teriflunomide (TFL).MethodsWe conducted a nationwide cohort study using data from the Danish Multiple Sclerosis Registry.Eligible participants had relapsing-remitting MS or clinically isolated syndrome and initiated TFL as their first treatment between 2013 and 2019. The effect of age, pretreatment relapses, T2L and EDSS scores on the risk of disease activity on TFL were stratified by sex.ResultsIn total, 784 individuals were included (57.4% females). A high number of pretreatment relapses (≥2) was associated with an increased risk of disease activity in females only (OR and (95% CI): 1.76 (1.11 to 2.81)). Age group 50+ was associated with a lower risk of disease activity in both sexes (OR females=0.28 (0.14 to 0.56); OR males=0.22 (0.09 to 0.55)), while age 35–49 showed a different impact in males and females (OR females=0.79 (0.50 to 1.23); OR males=0.42 (0.24 to 0.72)). EDSS scores and T2L did not show any consistent associations.ConclusionA high number of pretreatment relapses was only associated with an increased risk of disease activity in females, while age had a differential impact on the risk of disease activity according to sex. Clinicians may consider age, sex and relapses when deciding on TFL treatment.
Trends in the prevalence and pharmacological management of migraine during pregnancy in the UK, 2000–2018
Authors: Phillips Katherine , Nirantharakumar Krishnarajah , Wakerley Benjamin R , Crowe Francesca L 
Published: April 2024

BackgroundMigraine is common in women of reproductive age. This study aimed to (1) describe the prevalence of migraine in pregnant women in the UK, (2) identify drugs commonly prescribed for migraine during pregnancy and (3) identify characteristics associated with being prescribed medication for migraine during pregnancy.MethodsThe Clinical Practice Research Datalink pregnancy register, a database of pregnancy episodes identified in anonymised primary care health records, was used.Crude and age-standardised prevalence of migraine during pregnancy and the proportion of women with migraine prescribed drugs used for migraine management were calculated for each year between 2000 and 2018.Logistic regression was used to describe the relationship between patient characteristics and being prescribed migraine medication during pregnancy.Results1 377 053 pregnancies were included, of which 187 328 were in women with a history of migraine. The age-adjusted prevalence increased from 11.4% in 2000 to 17.2% in 2018. There was an increase in the rates of prescription for numerous medications for the management of migraine.Older women (adjusted OR (aOR) 1.41 (1.20 to 1.66)), women of black (aOR 1.40 (1.32 to 1.48)) and South Asian ethnicity (aOR 1.48 (1.38 to 1.59)), those living in the most deprived areas (aOR 1.60 (1.54 to 1.66)), women who were obese (aOR 1.39 (1.35 to 1.43)), smokers (aOR 1.15 (1.12 to 1.18)) and those with comorbid conditions were more likely to receive a prescription during pregnancy.ConclusionsRates of recorded migraine have increased over the past two decades as well as rates of prescribing in women with migraine. Higher prescribing rates are seen in certain groups, which has the potential to exacerbate health inequalities.
Thermophysical properties and geochemical characteristics of granites in the Tengchong area: indications for resource potential of hot dry rocks
Authors: Xu Lixia , Zhang Wei , Wang Guiling , Liao Yuzhong 
Published: April 2024

Ascertaining regional radiogeochemical characteristics and lithospheric thermal structure characteristics is paramount for identifying the resource potential of hot dry rocks. This study conducted thermal conductivity testing and whole-rock analyses of outcrop granites of different formation epochs from the Tengchong area. Moreover, combined with the previously published whole-rock data and the data related to radioactive heat production rates, this study conducted geological, geophysical and geothermal analyses. Key findings are:

(1) Granites in the Tengchong area exhibit an average radioactive heat generation rate of 5.54

μ

W m
−3
. Among them, the Late Cretaceous granites have an average radioactive heat generation rate of 8.08

μ

W m
−3
, suggesting high heat production granites.

(2) Granites in the Tengchong area present an average thermal conductivity of 3.135 W.m
−1
K
−1
, relatively akin to the average values of granitic rocks worldwide. Compared to granites of other epochs, the Late Cretaceous granites manifest significantly higher thermal conductivities, with an average of 3.28 W.m
−1
K
−1
.

(3) There is a negative correlation between the mica content and the thermal conductivity of the granites in the Tengchong area.
(4) The Tengchong area holds potential for hot dry rocks exploitation and is inferred to have a lithospheric structure characterized by hot mantle and cold crust.
Next Directions in the Neuroscience of Cancers Arising outside the CNS
Authors: Amit Moran , Anastasaki Corina , Dantzer Robert , Demir Ihsan Ekin , Deneen Benjamin , Dixon Karen O. , Egeblad Mikala , Gibson Erin M. , Hervey-Jumper Shawn L. , Hondermarck Hubert , Magnon Claire , Monje Michelle , Na'ara Shorook , Pan Yuan , Repasky Elizabeth A. , Scheff Nicole N. , Sloan Erica K. , Talbot Sebastien , Tracey Kevin J. , Trotman Lloyd C. , Valiente Manuel , Van Aelst Linda , Venkataramani Varun , Venkatesh Humsa S. , Vermeer Paola D. , Winkler Frank , Wong Richard J. , Gutmann David H. , Borniger Jeremy C. 
Published: April 2024

Summary:
The field of cancer neuroscience has begun to define the contributions of nerves to cancer initiation and progression; here, we highlight the future directions of basic and translational cancer neuroscience for malignancies arising outside of the central nervous system.
Radical Collaboration: Reimagining Cancer Team Science
Authors: Boehm Jesse S. , Jacks Tyler 
Published: April 2024

Summary:
Here, we define a future of cancer team science adopting “radical collaboration”—in which six “Hallmarks of Cancer Collaboration” are utilized to propel cancer teams to reach new levels of productivity and impact in the modern era. This commentary establishes a playbook for cancer team science that can be readily adopted by others.
A Vision for Democratizing Next-Generation Oncology Clinical Trials
Authors: Subbiah Vivek , Horgan Denis , Subbiah Ishwaria M. 
Published: April 2024

Summary:
Revolutionary advancements in oncology have transformed lives, but the clinical trials ecosystem encounters challenges, including restricted access to innovative therapies and a lack of diversity in participant representation. A vision emerges for democratized, globally accessible oncology trials, necessitating collaboration among researchers, clinicians, patients, and policymakers to shift from converting complex, exclusive trials into a dynamic, inclusive force against cancer.
Pushing the Boundaries of Liquid Biopsies for Early Precision Intervention
Authors: Anagnostou Valsamo , Velculescu Victor E. 
Published: April 2024

Summary:
Liquid biopsies are emerging as powerful minimally invasive approaches that have the potential to solve several long-standing problems spanning the continuum of cancer care: early detection of cancer, minimal residual disease tracking, and refinement of the heterogeneity of clinical responses together with therapeutic response monitoring in the metastatic setting. Existing challenges driven by technical limitations and establishment of the clinical value of liquid biopsies represent fields of active research that call for convergence science approaches to bridge scientific discovery with clinical care.
Precision Endpoints for Contemporary Precision Oncology Trials
Authors: Hoo Regina , Chua Kevin L.M. , Panda Pankaj Kumar , Skanderup Anders J. , Tan Daniel S.W. 
Published: April 2024

Summary:
Traditional endpoints such as progression-free survival and overall survival do not fully capture the pharmacologic and pharmacodynamic effects of a therapeutic intervention. Incorporating mechanism-driven biomarkers and validated surrogate proximal endpoints can provide orthogonal readouts of anti-tumor activity and delineate the relative contribution of treatment components on an individual level, highlighting the limitation of solely relying on aggregated readouts from clinical trials to facilitate go/no-go decisions for precision therapies.
Accelerating Drug Development Using Spatial Multi-omics
Authors: Goodwin Richard J.A. , Platz Stefan J. , Reis-Filho Jorge S. , Barry Simon T. 
Published: April 2024

Summary:
Spatial biology approaches enabled by innovations in imaging biomarker platforms and artificial intelligence–enabled data integration and analysis provide an assessment of patient and disease heterogeneity at ever-increasing resolution. The utility of spatial biology data in accelerating drug programs, however, requires balancing exploratory discovery investigations against scalable and clinically applicable spatial biomarker analysis.