bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porous graphene with high porosity derived from nitrogen-doped graphene aerogel for vapor adsorption and lithium–sulfur batteries
Authors: Liu Tianrui , Zhao Qingchao , Zhou Haotian , Zhang Songtong , Li Yongpeng , Sui Zhuyin 
Published: April 2024

Abstract
Graphene-based aerogels have garnered significant attention due to their combined advantages derived from both graphene and aerogels. Nevertheless, a key limitation in their practical applications arises from their relatively modest specific surface area and pore volume. In this study, porous graphene materials with high porosity are synthesized through the physical and chemical activation of nitrogen-doped graphene aerogel (NGA) using carbon dioxide and KOH as activating agents. Utilizing various characterization techniques, including scanning electron microscopy, nitrogen adsorption–desorption measurements, and X-ray photoelectron spectroscopy, the morphology, porous characteristics, and chemical composition of porous graphene are elucidated. The carbon dioxide-activated NGA (CNGA) maintains the spongy aerogel structure and exhibits a hierarchical porous structure encompassing micropores, mesopores, and macropores. Notably, CNGA exhibits a high specific surface area (2030 m2 g–1) and pore volume (5.4 cm3 g–1). Given its intriguing properties, CNGA demonstrates good performance as a gas adsorbent and sulfur host.
Conceptualizing radical solutions to global warming via pipeline transport green fuel ammonia produced from abundant renewable energy in equatorial waters
Authors: Kobayashi Hiroshi 
Published: April 2024

Abstract
The threat of global warming is imminent; however, fundamental solutions have yet to be presented. The current large-scale deployment of solar and wind power poses several challenges, including difficulties in storing large amounts of electricity and reduced power grid inertia. Additionally, rising surface temperatures thaw carbon-rich permafrost, glaciers, and Arctic ice, decreasing surface albedo (sunlight reflectance) and increasing atmospheric water vapor and methane, which have potent greenhouse effects. The result is a self-reinforcing cycle of rising surface temperatures, even if greenhouse gas (GHG) emissions are reduced to zero. These challenges can be overcome by (1) deploying numerous high-capacity floating offshore photovoltaic plants in equatorial waters with abundant renewable energy resources and generating sufficient electricity to meet the world’s primary energy needs; (2) using the generated electricity to synthesize green fuel ammonia, which is key to solving the challenges of renewable energy, and transporting and storing it globally via pipeline networks; and (3) continuously removing sufficient quantities of GHGs from the atmosphere to offset the self-reinforcing cycle. Upon deployment and implementation of such strategies by 2050, the Paris Agreement goals could be achieved and even return to pre-industrial levels. However, increased sea levels cannot be reversed.
Development of rp48d -ELISA and evaluation of its performance for detection of specific mycoplasma agalactiae antibody in vaccinated sheep
Authors: Esmaelizad Majid , Safari Aylar , Angaji Seyed Abdolhamid , Tadayon Keyvan , Ranjbar Mohammad mahdi , Majid Tebianian , Ghaderi Rainak , Esmaelizad Nazanin , Ferdowsi Hamidreza , Naemi Mahdi 
Published: April 2024

Abstract
Contagious agalactiae is a disease affecting small ruminants, caused by the bacterium Mycoplasma agalactiae. It is characterized by mastitis, polyarthritis, and keratoconjunctivitis. In regions heavily reliant on animal husbandry, this disease can result in substantial economic losses. Effective prevention methods include vaccination and accurate disease diagnosis in sheep and goats. The Surface lipoprotein P48 of M. agalactiae is constantly expressed and considered an immunodominant antigen present in all isolates. Antigenic variation is the primary cause of sensitivity differences in the p48-based serum assay. Recent studies have revealed fundamental differences in the p48 protein of Iranian isolates compared to previous ones. Therefore, rp48d protein was expressed in Escherichia coli BL21 (DE3) cells and purified using Ni-resin through an affinity batch formation method. Experimental sheep were divided into four groups for immunization: rp48d, RVSRI agalactiae vaccine, and two control groups (adjuvant and non-vaccinated control). Additionally, one hundred blood serum samples taken from vaccinated and non-vaccinated sheep (Fashandi breed) from various herds in the Taleghan region were analyzed using indirect ELISA. The results demonstrated that 97.50% and 100% sensitivity and specificity, respectively in rp48d-ELISA. Based on our findings, we can conclude that the in-house rp48d-ELISA is highly effective in detecting specific antibodies in vaccinated or infected sheep. This is due to the significant protein similarity between the structure of the rp48d protein utilized in the design of the ELISA test and mycoplasma agalactiae circulating in the region and used in vaccine production.
The influence of workplace spirituality on employees and organizations of three key industries in Ghana: A cross-sectional study
Authors: Kyei Kofi Adesi , Nortey Solomon Tetteh , Daniels Joseph 
Published: April 2024

Abstract

Background
Workplace spirituality is an emerging concept that has gained significant global scholarly attention in recent years. The phenomenon of inappropriate religious practices has dominated the Ghanaian corporate world partly because there are inadequate published data to facilitate the refinement and redefinition of questionable religious practices at the workplace. The purpose of this study was to assess the impact of workplace spirituality on employees and organizations of three key industries in Ghana. Additionally, the study also examined the scope of practices and challenges associated with the implementation of workplace spirituality in Ghana.
Methods
This research was a deductive cross-sectional study with a mixed-methods approach. Purposive sampling was used to recruit study participants from three different organizations known to implement some form of workplace spirituality practice. Quantitative data were collected with a semi-structured questionnaire whereas qualitative data were collected through interviews conducted with the respondents. The quantitative data obtained from the questionnaires were entered into a Microsoft Excel worksheet and analysed using STATA version 17. The interviews were recorded and later transcribed using NVivo version 10.
Results
A total of 133 participants were recruited into the study comprising approximately 60% males and 40% females. In all, 30.1% of the participants were between 25 and 34 years old whereas 15% were younger than 25 years. The majority of the participants practiced meditation (69.9%), reflection and self-awareness exercises (60.2%), prayer or other religious rituals (75.2%) as well as the sharing of personal religious stories and/or experiences (54.9%). The results show the support, encouragement and respect of organizations towards the practice of spirituality at the workplace as implied by the average mean of 4.10 (SD 1.13). Workplace spirituality had a major impact on the working life of the respondents.
Conclusions
The study highlights how workplace spirituality in Ghanaian organizations positively impacts employee engagement, satisfaction, and organizational commitment. Practices such as promoting personal beliefs and community activities contribute to a cohesive work environment. However, challenges such as intolerance and conflicting values exist. To fully leverage the benefits of workplace spirituality, organizations must address these challenges through strategies like transparent communication and cultural sensitivity training.
Synthesis, characterization and thermal studies of NIR fluorescent probe based on Poly(anthranilicacid)/Sand nanocomposite
Authors: Anbarasan R. , Kenet M. , Jancirani A. , Baskaran R. , Anand S. Hanish 
Published: April 2024

Abstract

Electrically conducting polymers are increasingly being used as NIR fluorescence probes in the area of biomedical engineering via the application of a structural modification process. Peroxydisulphate (PDS) initiated the chemical polymerization process of anthranilicacid (AnA) in a nitrogen atmosphere at a temperature of 0 to 5 oC. Rosebengal (RB) was used as an end capping agent, and vigorous stirring was maintained with and without sand. The produced polymer and its nanocomposite were examined using instruments for UV-visible, TGA, DSC, SEM, EDX, FTIR, CV, FES, HRTEM, and XRD. The thermal stability of the resulting polymers was investigated using non-isothermal degradation kinetics. Additionally, the thermodynamic parameter values were determined. In the 3% weight Sand loaded PAnA system, a conductivity value of 4.31x10− 2 S/cm was recorded, signifying a 90.3% yield percentage. Sand was added, and this resulted in an increase in the rate of polymerization (Rp). The PAnA/Sand nanocomposite system has a higher photo-conversion efficiency of 1.49 percent as compared to the RB end capped PAnA system. The experimental results are scrutinized closely and compared to values reported in the literature.
Constructing a Nucleotide Metabolism Related Prognostic Model Based on Bioinformatics to Explore the Potential Molecular Mechanisms of Glioblastoma
Authors: Jiang Luwei , Li Zixuan , Jiang Tao , Wang Xukou , Weng Chuanbo 
Published: April 2024

Abstract
Background: Glioblastoma (GBM) is one of the deadliest of all cancers. And nucleotide metabolism (NM) is the most critical link in malignant tumor cell replication. Therefore, we mined NM-related biomarkers to provide new direction for GBM treatment.
Methods: In TCGA-GBM, differences of gene expression between tumor and normal samples were compared to obtain DEGs. And differentially expressed NM-related genes (DE-NMRGs) were screened by intersecting DEGs and NMRGs. Then, biomarkers were screened by Cox regression analysis and proportional hazards (PH) assumption to construct the prognostic model, and the prognostic model was validated by plotting ROC, survival analysis and PCA. Next, to assess the ability of the prognostic model to serve as independent prognostic factor, independent prognostic analyses were performed across numerous clinical characteristics. Finally, the regulatory mechanism of GBM by biomarkers was further explored by single-gene GSEA, immune-related analysis, gene mutation analysis and protein expression validation.
Results: The NUDT1, CDA, UPP1 and ADSL were treated as the biomarkers to construct prognostic model, which indicated that the above biomarkers had good prognostic impact on GBM. The IDH mutation status, MGMT promoter status and riskScore were screened as independent prognostic factors. In TCGA-GBM samples, the expression of four biomarkers was significantly higher in GBM. Immune-related analysis showed that the cell abundance of activated memory CD4+ T cell, activated NK cell, M1 macrophage and neutrophil were significantly different between high- /low-risk groups. Tumor mutation load analysis revealed that the overall tumor mutation load was higher in the high-risk group.
Conclusion: The four biomarkers were obtained by bioinformatic analysis to construct new prognostic assessment model, providing theoretical reference value to guide the treatment of GBM.
Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo verbana
Authors: Kabeiseman Emily , Paulsen Riley T , Burrell Brian D 
Published: April 2024

Abstract

The endocannabinoid system plays a critical role in modulating both peripheral and central nervous system function. Despite being present throughout the animal kingdom, there has been relatively little investigation of the endocannabinoid system beyond the traditional animal model systems. In this study, we report on the identification and characterization of a fatty acid aminohydrolase (FAAH) in the medicinal leech, Hirudo verbana. FAAH is the primary enzyme responsible for metabolizing the endocannabinoid signaling molecule arachidonoyl ethanolamide (anandamide or AEA) and therefore plays a critical role in regulating AEA levels in the nervous system. This Hirudo FAAH (HirFAAH) is expressed in the leech central nervous system (CNS) and is an orthologue of FAAH-2 observed in vertebrates. Functionally, HirFAAH has serine hydrolase activity based on activity-based protein profiling (ABPP) studies using the fluorophosphonate probe TAMRA-FP. HirFAAH also hydrolyzes arachidonyl 7-amino, 4-methyl coumarin amide (AAMCA), a substrate specific to FAAH. Hydrolase activity during both the ABPP and AAMCA assays was eliminated by mutation at a conserved activity-binding site. Activity was also blocked by the known FAAH inhibitor, URB597. Treatment of Hirudo ganglia with URB597 potentiated synapses made by the pressure-sensitive mechanosensory neuron (P cell), mimicking the effects of exogenously applied AEA. The Hirudo CNS has been a useful system in which to study properties of endocannabinoid modulation of nociception relevant to vertebrates. Therefore, this characterization of HirFAAH is an important contribution to comparative studies of the endocannabinoid system.
Secondary structures of human calcitonin at different temperatures and in different membrane-mimicking environments, characterized by circular dichroism (CD) spectroscopy
Authors: Wärmländer Sebastian K.T.S. , Lakela Amanda L. , Berntsson Elina , Jarvet Jüri , Gräslund Astrid 
Published: April 2024

Abstract
Human calcitonin is a 32-residue peptide hormone that binds to the calcitonin receptor (CTR) and is involved in calcium regulation. The amino acid sequence displays a hydrophilic central segment flanked by hydrophobic C- and N-terminal regions, with a net charge of zero at neutral pH. This makes the molecule amphiphilic and conformationally flexible, and different CTR variants preferentially recognize different structural conformations of calcitonin. The peptide is secreted from the thyroid gland and is overproduced in some forms of thyroid cancer, and can then form cell-toxic aggregates. Characterizing the structural properties of calcitonin under different conditions is therefore important for understanding its receptor-binding and self-aggregation properties. Here, we used circular dichroism (CD) spectroscopy to monitor the secondary structure of human calcitonin in different environments. Calcitonin monomers were found to display a random coil structure with a significant amount of PPII-helix component in phosphate buffer, pH 7.3, at physiological temperatures. When agitated, the peptide formed soluble aggregates over time with mainly β-sheet secondary structure. In the presence of micelles of differently charged surfactants, monomeric calcitonin formed pure α-helix structure with cationic CTAB, a combination of α-helix and β-sheet with anionic SDS and zwitterionic SB3-14, and remained mainly random coil with non-charged DDM. Thus, the charge of the surfactant headgroup was found to be an important parameter for calcitonin’s interactions with membrane-mimicking micelles. Similar but not identical interactions with the surfactants were observed under oxidizing and reducing conditions.
Epidemiology of primary Extranodal Nonhodgkin lymphoma.
Authors: alnaseer Ghoufran , Suliman Siham 
Published: April 2024

Abstract
Introduction:
Lymphoma is the seventh most common type of malignant tumor in both sexes, accounting for 5% of cancers. Most non-Hodgkin's lymphomas arise in the lymph nodes or other lymphatic tissues such as the spleen, Waldeyer's ring, and the thymus gland. Localization outside of these sites is called primary extranodal non-Hodgkin's lymphoma, and it constitutes 24-40% of non-Hodgkin's lymphoma. The study aims to determine the prevalence of non-Hodgkin's lymphoma outside the primary nodule and its epidemiology.
Methods:
A cross-sectional study was conducted at Al-Biruni University Hospital in Damascus, Syria from January 2021 to December 2023. All patients with primary extranodal non-Hodgkin's lymphoma admitted to Al-Biruni University Hospital during this period were included in a questionnaire containing all the information. required.
Results:
The total sample was 151 patients, the majority of participants were males (62.3%), the majority were workers, the histological type in most patients 87 patients (57.6%) were DLBCL type, the cell type (84.2%) was at the expense of B cells, The location of the primary tumor was mostly in the stomach (29.1%), and most patients were in the first stage of the disease (50.4%).
Investimento Educacional: repercussões na implementação de políticas públicas de formação e valorização docente e na qualidade da educação brasileira
Authors: Gonçalves Brenda  Maria Vieira , Lima Francisco José de 
Published: April 2024

O investimento educacional é tema central de diversas pesquisas que buscam entender e discutir sobre a eficiência do ensino ofertado pela educação escolar no Brasil. Com o objetivo de discutir as repercussões do investimento educacional na implementação de políticas públicas de formação e valorização docente, bem como na qualidade do ensino ofertada nos dois grandes níveis da educação escolar brasileira, o trabalho está fundamentado nos pressupostos da pesquisa qualitativa e recorreu-se à revisão sistemática de literatura para o levantamento de material teórico. A busca pelos trabalhos foi realizada no Portal de Periódicos da CAPES, no período que compreendeu os anos de 2018 a 2022. Os trabalhos foram organizados em dois eixos de análise. A partir das análises e discussões, foi possível inferir que aspectos ligados ao investimento educacional brasileiro indicam um desmonte da educação pública e de tudo que ela representa para as classes marginalizadas que encontram nessa esfera um caminho para a ascensão profissional, pessoal e redução das desigualdades sociais. Assim, considera-se que investir em educação vai além de injetar recursos financeiros. É preciso que esse investimento seja planejado e eficaz, promovendo a implementação de políticas públicas que propiciem a formação e valorização docente, bem como um ensino de qualidade.
Palavras-chave: Investimento educacional; Políticas públicas; Formação docente; Qualidade da Educação; Desigualdade social.
FOREIGN EXPERIENCE IN PREVENTING PROTRACTED LEGAL PROCEEDINGS
Authors: Kabalskyi Roman O. 
Published: April 2024

The text highlights a key aspect of preventing abuses in civil procedure, namely, the establishment of clear and transparent rules of civil procedure. These rules serve as the foundation for a fair and efficient system of justice, defining the rights and obligations of all participants in the judicial process and serving as the basis for fair and effective justice. The importance of judicial oversight is also emphasized as a tool that guarantees compliance with these rules and safeguards the integrity of the process. Abuse of procedural rights can hinder the realization of legal protection and may manifest in various ways, including the postponement of court hearings and the submission or provision of incorrect evidence. Furthermore, the article discusses measures to counteract the abuse of procedural rights and optimize the course of the judicial process. The final point of the article underscores the relevance of this right at the international level, falling under the jurisdiction of the European Court of Human Rights and other international bodies. It calls on all states to adhere to the requirements for a reasonable timeframe for case consideration in accordance with European standards. In summary, the article provides a thorough overview and analysis
of the rules of civil procedure and their impact on ensuring fairness and efficiency within the judicial system. The main trends in preventing the prolongation of civil proceedings in foreign countries have been explored. These trends include the definition of simplified procedures based on the value of the claim, the application of a streamlined model for handling uncontested claims, the use of alternative dispute resolution methods, improvements in the process of filing lawsuits for timely case resolution, provisions for the hearing of cases in absentia of one of the parties, the introduction of electronic litigation systems, and the utilization of preventive mechanisms to expedite judicial proceedings.
Quality control of hourly rain gauge data based on radar and satellite multi-source data
Authors: Yan Qiaoqiao , Zhang Bingsong , Jiang Yi , Liu Ying , Yang Bin , Wang Haijun 
Published: April 2024

ABSTRACT

Rain gauge networks provide direct precipitation measurements and have been widely used in hydrology, synoptic-scale meteorology, and climatology. However, rain gauge observations are subject to a variety of error sources, and quality control (QC) is required to ensure the reasonable use. In order to enhance the automatic detection ability of anomalies in data, the novel multi-source data quality control (NMQC) method is proposed for hourly rain gauge data. It employs a phased strategy to reduce the misjudgment risk caused by the uncertainty from radar and satellite remote-sensing measurements. NMQC is applied for the QC of hourly gauge data from more than 24,000 hydro-meteorological stations in the Yangtze River basin in 2020. The results show that its detection ratio of anomalous data is 1.73‰, only 1.73% of which are suspicious data needing to be confirmed by experts. Moreover, the distribution characteristics of anomaly data are consistent with the climatic characteristics of the study region as well as measurement and maintenance modes of rain gauges. Overall, NMQC has a strong ability to label anomaly data automatically, while identifying a lower proportion of suspicious data. It can greatly reduce manual intervention and shorten the impact time of anomaly data in the operational work.
OPERACIONALIZAÇÃO DO E-SUS APS
Authors: Pereira dos Passos Isabella , De Santana Mauricéa Maria 
Published: April 2024

O e-SUS APS foi desenvolvido em 2013 para qualificar a gestão da informação, tendo como fundamento a ampliação da qualidade no atendimento à população. Este estudo teve como objetivo descrever os principais fatores relacionados com a operacionalização do e-SUS APS na perspectiva das equipes multiprofissionais (eMulti) do Distrito Sanitário (DS) VIII da cidade do Recife – Pernambuco. Trata-se de uma pesquisa quantitativa descritiva de corte transversal, utilizando dados primários coletados através de formulário online, organizado em quatro eixos, contendo questões relativas aos fatores gerais da operacionalização, registro, monitoramento e avaliação do e-SUS APS. E analisados conforme a distribuição das frequências absolutas e relativas sendo apresentados em tabelas. Os fatores gerais relacionados à operacionalização do e-SUS indicam que 63,6% dos profissionais não participaram de capacitação inicial na implantação do e-SUS e 54,5% não participaram de capacitações para atualizações. Quanto ao registro dos dados, 72,7% informaram não ter acesso exclusivo ao computador no horário do expediente e 81,8% realizando as atividades de registro do e-SUS fora do ambiente de trabalho. Referente ao monitoramento 59,1% e 68,2% descrevem respectivamente que não realizam atividade de monitoramento das informações contidas nos relatórios do PEC e do e-SUS Território. Resultados semelhantes foram encontrados no eixo da avaliação, visto que, 40,9% relataram não realizar avaliação dos dados. A compreensão da vivência da eMulti do DS VIII, indica a necessidade de adaptação do e-SUS de forma que contemple as atividades realizadas pela eMulti. E evidencia a necessidade de suporte da gestão local principalmente no quesito infraestrutura oferecida às equipes.