bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal microbiota as biomarkers for different colorectal lesions based on colorectal cancer screening participants in community
Authors: Li Gairui , Zhao Dan , Ouyang Binfa , Chen Yinggang , Zhao Yashuang 
Published: February 2025

IntroductionThe dysregulation of intestinal microbiota has been implicated in the pathogenesis of colorectal cancer (CRC). However, the utilization of intestinal microbiota for identify the lesions in different procedures in CRC screening populations remains limited.MethodsA total of 529 high-risk individuals who underwent CRC screening were included, comprising 13 advanced adenomas (Aade), 5 CRC, 59 non-advanced adenomas (Nade), 129 colon polyps (Pol), 99 cases of colorectal inflammatory disease (Inf), and 224 normal controls (Nor). 16S rRNA gene sequencing was used to profile the intestinal microbiota communities. The Gut Microbiota Health Index (GMHI) and average variation degree (AVD) were employed to assess the health status of the different groups.ResultsOur findings revealed that the Nor group exhibited significantly higher GMHIs and the lowest AVD compared to the four Lesion groups. The model incorporating 13 bacterial genera demonstrated optimal efficacy in distinguishing CRC and Aade from Nor, with an area under the curve (AUC) of 0.81 and a 95% confidence interval (CI) of 0.72 to 0.89. Specifically, the 55 bacterial genera combination model exhibited superior performance in differentiating CRC from Nor (AUC 0.98; 95% CI, 0.96-1), the 25 bacterial genera combination showed superior performance in distinguishing Aade from Nor (AUC 0.95). Additionally, the 27 bacterial genera combination demonstrated superior efficacy in differentiating Nade from Nor (AUC 0.82). The 13 bacterial genera combination exhibited optimal performance in distinguishing Inf from Nor (AUC 0.71).DiscussionOur study has identified specific microbial biomarkers that can differentiate between colorectal lesions and healthy individuals. The intestinal microbiota markers identified may serve as valuable tools in community-based CRC screening programs.
Ketogenic metabolic therapy for schizoaffective disorder: a retrospective case series of psychotic symptom remission and mood recovery
Authors: Laurent Nicole , Bellamy Erin L. , Tague Katherine A. , Hristova Donika , Houston Ally 
Published: February 2025

BackgroundSchizoaffective disorder is a severe psychiatric condition characterized by mood disturbances and psychotic symptoms. Standard treatments, primarily pharmacological, often fail to control symptoms fully and can lead to significant metabolic side effects. Emerging evidence suggests that ketogenic metabolic therapy (KMT), also known as the ketogenic diet, may offer a powerful alternative to conventional treatments for mood components and resolve psychiatric symptoms in patients with schizoaffective disorder.MethodsThis case series investigates the effects of KMT on two individuals diagnosed with schizoaffective disorder who pursued this therapy due to the ineffectiveness of conventional treatments. Both case presentations followed a modified ketogenic diet with medical oversight. Symptom changes in mood were assessed using validated tools, including the Generalized Anxiety Disorder-7 (GAD-7), Depression Anxiety Stress Scales (DASS-42), PTSD Checklist for DSM-5 (PCL-5), and Patient Health Questionnaire-9 (PHQ-9).ResultsBoth case presentations experienced the complete cessation of psychotic symptoms and improvements in mood. Case 1, a 17-year-old female, achieved full remission of severe suicidal ideation, hallucinations, and anxiety within 6 weeks, with sustained improvements at a 24-week follow-up. Case 2, a 32-year-old female, achieved full remission of chronic psychotic and mood symptoms by 6 months. Patients either achieved full psychiatric deprescription or were in the process of deprescription at time of follow-up.ConclusionThis case series demonstrates that ketogenic metabolic therapy can resolve chronic psychotic and mood symptoms in patients with schizoaffective disorder, leading to full remission and significant functional recovery and reported improvements in quality of life that extend beyond symptom control with standard of care interventions.
Comparative and synergistic impacts of lime and biochar on soil properties, nitrogen transformation, and microbial function in acidic soils under tobacco cropping
Authors: Zhang Bianhong , Tang Lina , Chen Zhicheng , Chen Xiaoyan , You Lindong , Pan Ruixin , Chen Ting , Liu Yifei , Lin Wenxiong , Huang Jinwen 
Published: February 2025

IntroductionLime and biochar are widely utilized to enhance nitrogen utilization in crops grown on acidic soils, though each has its own set of limitations. Understanding their combined effects is crucial for optimizing soil remediation strategies.MethodsThis study investigates the impact of lime and biochar on nitrogen utilization efficiency (NUE) in a tobacco monoculture system, which has been practiced for 20 years on acidified soils in Fuzhou, southeastern China, over the period from 2021 to 2022. Four treatments were applied: control (CK), lime alone (L), biochar alone (B), and a lime-biochar combination (L+B).ResultsThe results indicated that all treatments significantly improved NUE, with increases ranging from 20.07% to 27.17% compared to CK. Biochar (B) was more effective than lime (L), and the combined treatment (L+B) showed comparable effects to biochar alone. Correlation analysis revealed that increases in soil pH and exchangeable base cations facilitated nitrogen transformation, thereby enhancing NUE. Lime treatments (L, L+B) promoted nitrification potential in rhizosphere soil, whereas biochar application (B, L+B) resulted in elevated nitrate nitrogen content. Microbial functional analysis indicated that lime (L, L+B) enhanced nitrification, while biochar (B, L+B) fostered dissimilatory nitrate reduction, thereby improving nitrogen retention. Pearson correlation analysis demonstrated a strong positive relationship between dissimilatory nitrate reduction and both soil alkali-hydrolyzable nitrogen and nitrate nitrogen contents.ConclusionThese findings suggest that lime enhances nitrification, while biochar promotes nitrate retention, together increasing soil nitrogen availability. The combined application of lime and biochar integrates these benefits, yielding results comparable to biochar alone. This study offers valuable insights into the synergistic use of lime and biochar for mitigating soil acidification and optimizing nitrogen management in agricultural systems.
Digitally assessing social–emotional skills in early school years: initial validation of a screening instrument
Authors: Kogler Andrea , Gasteiger-Klicpera Barbara , Prinz Katharina , Paleczek Lisa 
Published: February 2025

IntroductionSocial–emotional skills are essential in everyday interaction and develop in early and middle childhood. However, there is no German instrument to help primary school students identify their strengths and weaknesses in different social–emotional skills that does not rely on written language. This paper introduces a new digital instrument, the GraSEF: Grazer Screening to assess Social–Emotional Skills, which was developed to measure (1) Behavior in Social Situations, (2) Prosocial Behavior, (3) Emotion Regulation Strategies, (4) Emotion Recognition and (5) Self-Perception of Emotions using different test formats (e.g., situational judgement test, self-assessment, performance tests). In the GraSEF, students work through an online survey tool, using audio instructions to guide them through the test.MethodsThe present study analyses the responses of second graders (Mage = 8.23 years, SDage = 0.48, 48% female). The intention was to gain initial insight into the instrument’s psychometric quality and user-friendliness.ResultsIn general, the instrument was found to have acceptable to good internal consistency, sufficient discriminatory power and item difficulty. However, one subtest (5: Self-Perception of Emotions), as well as three situations of the situational judgment test (1: Behavior in Social Situations), were excluded due to unsatisfactory fit and distribution. The validity check revealed low to moderate correlations between teacher rating and student scores. On average, students completed the screening in about 30 min and provided positive feedback regarding usability.DiscussionWhile the small sample size only provides preliminary insight into the instrument’s psychometric quality, the results suggest that the GraSEF can reliably measure various dimensions of social–emotional skills in second graders, even among those with low reading skills.
Numerical Analysis of Combustion and Thermal Performance of a Bluff-Body and Swirl-Stabilized Micro-Combustor with Premixed NH3/H2/Air Flames
Authors: Sheykhbaglou Soroush , Dimitriou Pavlos 
Published: February 2025

This research presents a novel bluff-body and swirl-stabilized micro-combustor fueled by an ammonia/hydrogen mixture, aimed at enhancing flame stabilization for zero-carbon micro-combustion-based power generators. Employing numerical simulations, the study examines the effects of bluff-body geometry, inlet mass flow rate, vane angle, and combustor material on combustion and thermal efficiencies. Key findings demonstrate that the shape of the bluff-body significantly influences the combustion outcomes, with cone-shaped designs showing the lowest radiation efficiency among the tested geometries. The study identifies an optimal inlet mass flow rate of 9×10−6 kg/s, which achieves a combustion efficiency of 99% and superior uniformity in the mean outer wall temperature. While variations in flow rate primarily affect NO emissions and outer wall temperatures, they have minimal impact on combustion efficiency. Further analysis reveals that adjusting the vane angle from 15 to 60 degrees significantly improves mean outer wall temperatures, temperature uniformity, and combustion and radiation efficiencies, while also reducing NO emissions. The 60-degree angle is particularly effective, achieving approximately 44% radiation efficiency. Additionally, material selection plays a pivotal role, with silicon carbide outperforming others by delivering an optimized mean outer wall temperature (approximately 910 K), radiation efficiency (38.5%), and achieving the most uniform outer wall temperature. Conversely, quartz exhibits significantly lower thermal performance metrics.
The Impact of SGLT2 Inhibitors and GLP-1 Receptor Agonists on 24-hour Urine Parameters
Authors: Schaub Jennifer A. , Oerline Mary K. , Crivelli Joseph J. , Maalouf Naim M. , Best Sara L. , Asplin John R. , Hollingsworth John M. , Shahinian Vahakn , Hsi Ryan S. 
Published: February 2025

Background:
Emerging data suggest sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1-RA) may lower stone risk.

Methods:
We characterized 24-hour urine parameters among individuals with kidney stone disease receiving these agents using Medicare claims from beneficiaries with urine collections processed by a central laboratory between January 2010 and December 2019. We identified a cross-sectional cohort with diabetes and a prescription fill for SGLT2i or GLP-1RA within the six months preceding their urine collection and matched controls. We additionally identified a subset of patients who performed two collections and had a prescription fill for SGLT2i or GLP-1RA before the second collection, but not the first. We compared across 24-hour urinary parameters in both cohorts and adjusted for multiple comparisons.

Results:
The cross-sectional cohort included 124 patients with a prescription fill for SGLT2i (and 620 matched controls), and 349 patients with a prescription fill for GLP-1RA (and 349 matched controls). Compared to controls, patients on SGLT2i had a higher mean urine citrate (838 mg vs. 636 mg; p<0.01) and volume (2.4L vs. 2.0 L; p<0.01) with improved calcium phosphate supersaturation (p<0.01). Lower urine pH and higher sulfate, and uric acid were observed in the SGLT2i group (p<0.01 for each). There were no significant differences in urine parameters with GLP-1RA. In the longitudinal analyses of SGLT2is (59 patients) and GLP-1RAs (154 patients), there were no significant differences in urinary parameters.

Conclusions:
SGLT2is were associated with higher urine volume and citrate in a cross-sectional cohort. GLP-1RA were not associated with changes that would reduce stone risk.
Peritoneal Dialysis Patient Transfers to Hemodialysis
Authors: Adoukonou Nanti E. , Boyer Annabel , Lobbedez Thierry , Bechade Clémence , Lanot Antoine 
Published: February 2025

Background:
The end of peritoneal dialysis (PD) can be marked by kidney transplantation, death, or transfer to hemodialysis (HD). We compared the risks of the different reasons for transfer to HD in PD patients according to the use of assistance for PD care, PD modality, and the suboptimal starter status.

Methods:
This was a retrospective study using data from the French Language Peritoneal Dialysis Registry from patients who started PD between January 1, 2002, and December 31, 2018. We used Cox and Fine Gray survival models to evaluate the risks of transfer to HD due to PD inadequacy, infection, mechanical issue, psychosocial issue, others PD-related and others non-PD-related causes. Models were evaluated for three periods of PD vintage: 0 to 6 months, 6 to 18 months, and after 18 months.

Results:
The study included 15,974 incident PD patients treated in 170 French PD units. There were 6,835 deaths, 5,108 transfers to HD and 3,092 renal transplantations. Nurse-assisted PD was associated with a lower risk of transfer to HD for infection in the first 18 months (cs-HR 0.51, 95%CI 0.31-0.83 before 6 months) and for adequacy issues after 6 months (cs-HR 0.59, 95%CI 0.51-0.70 after 18 months). The risk of transfer for mechanical issue was higher in CAPD compared to APD during the first eighteen months (cs-HR 1.41, 95%CI 1.00-1.99 before 6 months), but CAPD was associated with a lower risk for adequacy, infectious or mechanical issue after 18 months. Finally, suboptimal starters have a higher risk of transfer due to psychosocial challenges in the first 6 months (cs-HR 1.70, 95%CI 1.03-2.81).

Conclusions:
Distinct factors are associated with the risk of transfer from PD to in-center HD, according to the cause of the transfer. Some preventive measures targeting these risk factors may help to maintain patients in PD.
Uso estético e terapêutico da toxina botulínica tipo A: relato de caso
Authors: Martins Lídia Batista Conrado , Mattos Thiago Borges , Filho Francisco Cerdeira , Sinhoroto Karina Cazetta , Tavares Luciana Claúdia Diniz , Souza Renan Abdallah Alves de , Viana Alexandro de Oliveira , Magri Ramira 
Published: February 2025

Objetivo: descrever a aplicabilidade e funcionabilidade da toxina botulínica tipo A mediante parâmetros estéticos e terapêuticos através da descrição de casos clínicos com diferentes nuances. Detalhamentos de Caso: Paciente do gênero feminino, 31 anos, diagnosticado com Paralisia de Bell procurou atendimento odontológico por sequelas crônicas na hemiface, levando a assimetria facial. Pacientes de ambos os gêneros, 56, 37, 30 , apresentaram alta tonicidade em grupos musculares específicos do terço superior e inferior resultando em rugas dinâmicas expressivas e assimetria em subunidades faciais.. A técnica consistiu na aplicação intradérmica com reconstituição 100U/2ml, com raio de ação local de 1cm dentro da variação de 20 e 40mm do ponto de injeção. Conclusão: Resultados satisfatórios, seguros e eficientes foram obtidos mediante a aplicação de pontos complementares, com dosagens individualizadas intradérmicamente e intramuscularmente, visando a previsibilidade dos resultados.
GAMBARAN REGULASI EMOSI ORANGTUA DENGAN ANAK BERKEBUTUHAN KHUSUS
Authors: Insani Uswatun , Itsna Ita Nur 
Published: February 2025

Orang tua memiliki peranan yang sangat penting dalam mengasuh, mendidik, dan merawat anak. Hal ini tidaklah mudah, apalagi ditambah kondisi anak yang memiliki kebutuhan khusus. Diperlukan penerimaan dan kesabaran dalam kesehariannya menghadapi keunikan yang dimiliki anaknya. Regulasi emosi orang tua yang memiliki anak berkebutuhan khusus merupakan kemampuan individu dalam mengelola emosi dan ditunjukkan dalam tingkah lakunya dalam merawat anak berkebutuhan khusus. Penelitian ini menggunakan instrument tentang regulasi emosi yang sudah baku dan didapatkan kategorisasi hasil pengukuran emotional regulation dibagi menjadi 2 yaitu cognitive reappraisal (mengendalikan emosi dengan mengubah cara pikir) dan expressive supression (menyimpan perasaan). Penelitian ini bertujuan untuk mengetahui gambaran regulasi emosi pada orang tua yang memiliki anak berkebutuhan khusus. Penelitian ini diharapkan bermanfaat sebagai referensi bagi orang tua yang memiliki anak berkebutuhan khusus dalam memahami dan menerapkan regulasi emosi selama dalam pengasuhan.
Mekanisme Resistensi Bakteri Terhadap Antibiotika
Authors: Gunardi Wani Devita 
Published: February 2025

AbstrakSampai saat ini, pengobatan penyakit infeksi masih tergantung dari penggunaan antibiotika. Pemilihan antibiotika tidak saja berdasarkan spektrum antibiotika tapi juga harus berdasarkan farmakokinetik dan farmakodinamik, kemampuan menyebabkan resistensi, keamanan dan biaya. Resistensi adalah suatu fenomena kompleks yang terjadi dengan pengaruh dari mikroba, obat antimikroba, lingkungan dan penderita, dapat terjadi terpisah atau sebagai interaksi bersama. Bakteri melibatkan mekanisme biokimia yang canggih dalam rangka menyelamatkan diri dari efek letal antibiotika seperti memproduksi enzim yang merusak daya kerja obat, mengubah tempat/lokus tertentu, menurunkan akses ke target site, mengubah metabolic pathway yang menjadi target obatÂ Kata kunci : resistensi antibiotik, drug effluxÂ AbstractCurrently, antibiotics are critical to the treatment of bacterial infections. Antibiotic resistance continues to expand for a multitude of reasons, including over prescription of antibiotics by the physicians,no-completions of prescribed antibiotics treatment by the patients, use of antibiotics in animals as growth enhancers (primarily by the food industry), increased international travel, and poor hospital hygiene. In prescribing antibiotics, we have to mentioned the pharmacokinetics, pharmacodynamics, the safety and the cost. Resistance is a complex phenomena that involved microorganism, antimicrobial agents, environmental the host. There are several mechanism of bacteria to be resistance including producing enzymes, changing target site, reducing access to the target site and changing metabolic pathway of the target site of antibiotics.Â Key words : antibiotic resistance, drug efflux
Gambaran Komplikasi pada Jantung Penderita Diabetes Melitus Studi Kasus dalam 3 Tahun di RSUD KOJA Periode November 2005 - November 2008
Authors: Theresia Swesti , Santoso Mardi , . Imelda 
Published: February 2025

AbstrakDiabetes Melitus (DM) adalah kondisi kadar gula dalam darah lebih tinggi dari biasa/normal dan disertai berbagai kelainan metabolik. Hal ini menimbulkan komplikasi akut dan kronik berupa ketoasidosis diabetikum, hipoglikemia, kardiovaskular, retinopati diabetikum, nefropati, ulkus dan gangren diabetika. Berdasarkan peningkatan komplikasi penyakit jantung pada pasien diabetes, penelitian ini dilakukan untuk mengetahui prevalensi penyakit ini di bagian Penyakit Dalam RSUD KOJA yang dirawat selama bulan November 2005 sampai November 2008.Penelitian ini didukung dengan metodologi survei yang menggunakan studi deskriptif yang diambil dari rekam medis Rumah Sakit Umum Daerah Koja. Dari 585 pasien diabetes yang dirawat selama periode tersebut, ditemukan bahwa 130 pasien dengan komplikasi jantung. Prevalensi terbanyak dari penyakit ini ditemukan pada wanita sebesar 86 orang (66.15%) dengan prevalensi tertinggi pada rentang usia 45-64 tahun sebesar 50%. Prevalensi dari penyakit diabetes dengan komplikasi pada jantung di rumah sakit ini tersering pada pasien wanita antara periode November 2005-November 2008 yang mana terus meningkat. Penelitian ini juga memaparkan bahwa prevalensi penyakit terbanyak pada pasien diabetes dengan komplikasi penyakit jantung berupa Congestive Heart Failure.Â Kata kunci : Komplikasi penyakit jantung, Diabetes, KojaÂ Â AbstractDiabetes Mellitus (DM) is a condition of blood sugar higher that usually is followed by complication of metabolic. This is also create acute and cronic complication such as cetoasidosis diabeticum, hypoglicemic, cardiovascullar, retinopati diabeticum, nephropathy, ullcus, and gangren diabetica. Due to the increasing number of cardiovascular complication in diabetic patients, the study was done to know the prevalence of this disease in the internal medicine of KOJA District General Hospital who have been hospitalized during November 2005 till November 2008. This study was conducted using descriptive study from the hospital medical records.Of the 585 Diabetic patients who have been hospitalized during that period, it has been found that 130 patients with cardiovascular complication. The prevalence of this disease in female were 86 (66.15%) with the highest prevalence (50%) in the patients of 45-64 years old.The prevalence of diabetic patients with cardiovascular complication among the female patients in this hospital within this period (November 2005-November 2008) were remain high and the prevalence of among the disease with cardiovascular complication of diabetic patients were Congestive Heart Failure.Â Key words: Cardiovasculer complication, diabetic, Koja
Peran Bakteri Wolbachia pada Patogenesis Onkoserkosis Monica Puspa Sari
Authors: Sari Monica Puspa 
Published: February 2025

AbstrakInfeksi dengan nematoda parasit Onchocerca volvulus yang ditularkan melalui gigitan lalat hitam Simulium, dihubungkan dengan terjadinya reaksi inflamasi pada kulit dan kornea,Â dapat menyebabkan kebutaan. Kerusakan kornea yang terjadi dihasilkan dari respon inflamasi host akibat mikrofilaria yang mengalami degenerasi pada mata. Percobaan menggunakan tikus sebagai hewan coba dengan keratitis dilakukan untuk melihat respon imun dan inflamasi yang terjadi yang dihubungkan dengan onkoserkosis. Peran Wolbachia dalam perkembangan keratitis, mengindikasikan bahwa respon imun bawaan pada awalnya sangat penting dalam patogenesis onkoserkosis pada mata. Pemberian antibiotik selain untuk membunuh Wolbachia, juga sangat penting dalam menurunkan dan mencegah manifestasi klinis yang ditimbulkan.Â Kata kunci : Onchocerca volvulus, Wolbachia, onkoserkosisÂ AbstractInfection with Onchocerca volvulus parasitic nematodes transmitted through the bite of the black fly Simulium, associated with inflammatory reactions in the skin and cornea, can lead to blindness. Corneal damage occurs resulting from the host inflammatory response due degenerating microfilariae in the eye. Experiments using mice as experimental animals with keratitis done to see the immune andÂ inflammatory response that occurs associated with Onchocerciasis. Role of Wolbachia in the development of keratitis indicate that the innate immune response in the beginning is very important in the pathogenesis of onchocerciasis on the eyes . Antibiotics in addition to killing Wolbachia , is also very important in reducing and preventing the clinical manifestations caused.Â Keywords : Onchocerca volvulus, Wolbachia, OnchocerciasisÂ Â Â