bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China
Authors: Xu Jing-Wen , Guan Xiao-Bo , Wang Xue-Ying , Feng Yang , Zhang Qi , Zhu Jun-Juan , Chen Jian-Hua 
Published: April 2024

BACKGROUND
Prior studies have noted great variability in the plasma levels of risperidone (RIS). Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption, metabolism, and other predictors of metabolic dysregulation; however, these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.
AIM
To ascertain the characteristics of chronic schizophrenic patients treated with RIS, and to assess their relationship with plasma RIS levels.
METHODS
This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service. The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography. The patients’ demographic and clinical characteristics, and psychopathologies were assessed, and the associations between clinical variables and plasma levels of RIS were explored.
RESULTS
Male patients received higher doses of RIS than female ones, but plasma concentrations of RIS and risperidone + 9-hydroxyrisperidone (active moiety) were higher in female patients. Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale (PANSS) were significantly positively correlated with plasma concentrations of risperidone + 9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects. In male subjects, we found a statistically significant positive correlation between the concentrations of risperidone + 9-hydroxyrisperidone in plasma/(dose × kg) and age, mean PANSS negative subscale scores, mean PANSS general psychopathology subscale scores, and mean PANSS total scores.
CONCLUSION
Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.
Analysis of acupoint massage combined with touch on relieving anxiety and pain in patients with oral implant surgery
Authors: Qu Jin-Hong , Shou Cheng-Cheng , He Xin , Wang Qin , Fang Yue-Xia 
Published: April 2024

BACKGROUND
Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local anesthesia. Because patients under local anesthesia are conscious during this procedure, compared with general anesthesia-related operations, they are more likely to experience negative emotions, such as anxiety and tension. These emotional reactions result in shivering and chills in the limbs, leading to poor doctor-patient cooperation and even avoidance of treatment. In traditional Chinese medicine, it is believed that acupoint massage regulates blood and Qi, dredge menstruation, and relieve pain, which is beneficial for patients’ emotional adjustment; however, there are few related clinical studies.
AIM
To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch therapy.
METHODS
One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups, according to a random number table, with 50 patients in each group. The control group received routine intervention, and the study group received acupoint massage combined with touch on the basis of the control group. Anxiety [assessed using the Modified Dental Anxiety Scale (MDAS)], pain severity, blood pressure, heart rate, and satisfaction were compared between the two groups.
RESULTS
Before intervention, the difference in MDAS score between the two groups was not significant (P > 0.05), while after the intervention, the MDAS scores decreased in both groups compared with those before the intervention (P < 0.05); the MDAS score of the study group was lower than that of the control group, with a statistically significant difference (P < 0.05). The degree of pain in the intervention group was significantly lower than that in the control group (P < 0.05). Before the intervention, there were no significant differences in systolic and diastolic blood pressures or heart rate between the two groups (P > 0.05). The systolic and diastolic blood pressures and heart rate in the intervention group, during and after the intervention, were significantly lower than those in the control group (P < 0.05). The total degree of satisfaction in the study group was significantly higher than that in the control group (P < 0.05).
CONCLUSION
Acupoint massage combined with touch better relieves anxiety and pain in patients undergoing dental implant surgery, improving the perioperative comfort of these patients and ensuring safety and a smooth operation.
Resilience provides mediating effect of resilience between fear of progression and sleep quality in patients with hematological malignancies
Authors: Tian Yuan , Wang Ying-Li 
Published: April 2024

BACKGROUND
Hematological tumors are common malignant tumors, with high morbidity and mortality rates. Most patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease, rapid progression, high recurrence rates, complex treatment methods, and treatment costs.
AIM
To explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological malignancies.
METHODS
A cross-sectional analysis of 100 patients with hematological malignancies, treated in the First Affiliated Hospital of Jinzhou Medical University between August 2022 and August 2023, was conducted. Patients were assessed using a general data survey, a simplified scale for the fear of progression (FoP) of disease, a resilience scale, and the Pittsburgh Sleep Quality Index. Statistical analysis was conducted to determine the relationship between various patient characteristics and FoP, resilience, and sleep quality. Spearman’s correlation analysis was used to examine the correlations between mental resilience, FoP, and sleep quality.
RESULTS
The total FoP score mean value in patients with hematological malignancies was 38.09 ± 5.16; the total resilience score mean value was 40.73 ± 7.04; and the Pittsburgh Sleep Quality Index score mean value was 10.72 ± 1.90. FoP, resilience, and sleep quality of the patients were associated with family per capita monthly income and patient education level (P < 0.05). Spearman correlation analysis revealed that FoP was negatively correlated with resilience and sleep quality scores (r = -0.560, -0.537, P < 0.01), respectively, and resilience was significantly associated with sleep quality scores (r = 0.688, P < 0.01). Mediation analysis showed that the mediating effect of resilience between FoP and sleep quality in patients with hematological malignancies was -0.100 and accounted for 50.51% of the total effect. This indicated that FoP directly and indirectly affected sleep quality through the mesomeric effect of resilience.
CONCLUSION
Resilience is an intermediary variable between FoP and sleep quality in patients with hematological malignancies. Medical staff should evaluate and follow-up FoP and resilience to implement measures to improve sleep quality.
Nurse anesthetists’ perceptions and experiences of managing emergence delirium: A qualitative study
Authors: Xin Yi , Lin Fu-Cai , Huang Chen , He Bin , Yan Ya-Ling , Wang Shuo , Zhang Guang-Ming , Li Rui 
Published: April 2024

BACKGROUND
This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium (ED), a common and complex postoperative complication in the post-anesthesia care unit. The role of nurses in managing ED is critical, yet research on their understanding and management strategies for ED is lacking.
AIM
To investigate anesthetic nurses’ cognition and management experiences of ED in hopes of developing a standardized management protocol.
METHODS
This study employed a descriptive phenomenological approach from qualitative research methodologies. Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research subjects. Semi-structured interviews were conducted, and the data were organized and analyzed using Colaizzi’s seven-step analysis method, from which the final themes were extracted.
RESULTS
After analyzing the interview content, four main themes and eight subthemes were distilled: Inefficient cognition hinders the identification of ED (conceptual ambiguity, empirical identification), managing diversity and challenges (patient-centered safe care, low level of medical-nursing collaboration), work responsibilities and pressure coexist (heavy work responsibilities, occupational risks and stress), demand for high-quality management (expecting the construction of predictive assessment tools and prevention strategies, and pursuing standardized management processes to enhance management effectiveness).
CONCLUSION
Nursing managers should prioritize the needs and suggestions of nurses in order to enhance their nursing capabilities and provide guidance for standardized management processes.
Tanshinone IIA improves Alzheimer’s disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis
Authors: Yang Long-Xiu , Luo Man , Li Sheng-Yu 
Published: April 2024

BACKGROUND
Alzheimer’s disease (AD) is a neurodegenerative condition characterized by oxidative stress and neuroinflammation. Tanshinone IIA (Tan-IIA), a bioactive compound isolated from Salvia miltiorrhiza plants, has shown potential neuroprotective effects; however, the mechanisms underlying such a function remain unclear.
AIM
To investigate potential Tan-IIA neuroprotective effects in AD and to elucidate their underlying mechanisms.
METHODS
Hematoxylin and eosin staining was utilized to analyze structural brain tissue morphology. To assess changes in oxidative stress and neuroinflammation, we performed enzyme-linked immunosorbent assay and western blotting. Additionally, the effect of Tan-IIA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Genetic changes related to the long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1)/microRNA (miRNA, miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain reaction.
RESULTS
In vivo , Tan-IIA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD mice. In vitro experiments showed that Tan-IIA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability, apoptosis, oxidative stress, and neuroinflammation. In this process, the lncRNA NEAT1 - a potential therapeutic target - is highly expressed in AD mice and downregulated via Tan-IIA treatment. Mechanistically, NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p, which activates nuclear factor kappa-B (NF-κB) signaling, leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein, which exacerbates AD. Tan-IIA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB signaling.
CONCLUSION
This study demonstrates that Tan-IIA exerts neuroprotective effects in AD by modulating the NEAT1/miR-291a-3p/Rab22a/NF-κB signaling pathway, serving as a foundation for the development of innovative approaches for AD therapy.
Empreendedorismo feminino: capacitação direcionada às mulheres em situação de vulnerabilidade do município de Cláudio
Authors: Silva Valdilene Gonçalves Machado , Vieira Maria Augusta de Assis , Barros Nívea Mara de Faria , Silva Talita Graziela da 
Published: April 2024

A proposta deste trabalho foi fomentar o empreendedorismo entre as mulheres em situação de vulnerabilidade de Cláudio/MG, como alternativa para geração de renda, para seu fortalecimento e enfrentamento das questões sociais em que estiver envolvida. Para isso, foi necessário traçar o perfil das moradoras, identificar se já desenvolviam algum tipo atividade remunerada, mapear as suas competências, desenvolver oficinas para aprendizagem de trabalhos artesanais e desenvolver e ministrar um curso empreendedorismo. Para tanto, foi realizada uma pesquisa descritiva, com abordagem quantitativa através de um estudo de caso, para levantamento de dados que auxiliariam na realização de atividades extensionistas. Assim, foi ministrado um curso de empreendedorismo e uma oficina de artesanato em EVA. Identificou-se que o perfil das moradoras que participaram do projeto eram, em sua maioria, mulheres com ensino fundamental incompleto, não tinham nenhuma atividade remunerada e possuiam até três filhos. Elas demonstraram interesse em aprender sobre trabalhos artesanais em EVA para aumentar a renda familiar. O curso de empreendedorismo e a oficina de trabalhos artesanais em EVA foram ministrados muito bem avaliados pelas participantes por lhes proporcionar novas perspectivas.
Pneumonia associada à ventilação mecânica: uma revisão narrativa
Authors: Zanuto Bruno Silva , Cavalcante Aldeir da Silva , Oliveira Sobrinho Ivanilton Alves de , Silva Ana Claudia Rodrigues da , Freitas Camila Melo de , Coimbra Jessica de Oliveira , Rother Laura Soletti , Ataide Natalia da Silva , Ataides Walace Silva , Silva Vanderleia Rodrigues da , Vale Victor Hugo Araújo do , Jesus Laura Souza de , Basso Orisson de Steffani 
Published: April 2024

A pneumonia associada a ventilação (PAV) é considerada uma pneumonia hospitalar adquirida em pacientes em uso de ventilação mecanica por mais de 48 horas e caracterizada pela presença de novos infiltrados pulmonares em imagem de tórax, declínio respiratório, febre e presença de secreção purulenta em vias aéreas. A PAV pode ser causada por uma variedade de microrganismos, incluindo gram-negativos e gram-positivos, com Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae e Staphylococcus aureus sendo os mais comuns. Pesquisas mostram que a fisiopatologia da PAV está relacionada à colonização das vias aéreas inferiores por microorganismos da orofaringe ou por infecções secundárias. Pacientes em ventilação mecânica têm mecanismos de defesa das vias aéreas comprometidos, o que aumenta o risco de infecção. O diagnóstico é baseado em achados clínicos, microbiologicos e radiologicos, porém estudos recentes tem mostrado a eficácia de biomarcadores como auxiliares no diagnóstico, por exemplo, proteína C reativa, procalcitonina ou receptor desencadeante expresso em células mieloides (TREM-1). O manejo da PAV envolve a distinção entre tratamento empírico e tratamento específico. É essencial que a abordagem terapêutica seja personalizada, levando em consideração a gravidade da doença, as condições subjacentes do paciente, os fatores de risco para microrganismos resistentes e a sensibilidade aos antibióticos na região específica.
CETOACIDOSE DIABÉTICA: AVALIAÇÃO CLÍNICA NA POPULAÇÃO PEDIÁTRICA
Authors: Vargas Eduardo Sampaio , Oliveira Thaís Pedra , Paz Valéria Nunes , Freire Rodrigo José Bumussa , Duran Welintton , Bandeira Ana Flávia de Castro , Sabino Milla Proto de Mattos , Silva Gabriella Elvira de Medeiros , Soares Paula Cristina Santos , Armine Gabriella Demaria , Viana Gustavo Arlen de Freitas , Cecchin Bruna , Andrade Erica Gonçalves Cordeiro Cruz de , Souza Cassila Solange Silva Bezerra , Lucena Romulo Gonçalves de Moura , Lopes Mateus Dionatan Gobetti , Dantas João Paulo Araújo , Gomes Thamires Mendes , Machado João Marcus Mota , Moreira Giovanna Mariotti 
Published: April 2024

Introdução: Este artigo de revisão aborda a cetoacidose diabética (CAD) na população pediátrica, uma complicação aguda do diabetes mellitus que exige reconhecimento e manejo precoces para evitar desfechos adversos. Objetivo: Analisar a avaliação clínica dos pacientes pediátricos que estão no estado de Cetoacidose Diabética. Metodologia: Essa revisão integrativa da literatura, foi realizada por busca em base de dados de artigos que correspondessem ao tema proposto. Incluiu-se avaliação dos artigos elegíveis na íntegra, excluindo aqueles que não se enquadram nos objetivos do estudo, teses e dissertações, sem contabilizar duplicatas. Resultados e Discussão: Crianças com CAD tipicamente apresentam anorexia, náuseas, vômitos e dor abdominal, podendo ocorrer dor focal, além de hiperventilação. Destacam a complexidade do diagnóstico de CAD em pacientes jovens, dado que os sintomas iniciais podem ser sutis ou mal interpretados. A revisão revela a importância crítica de uma abordagem clínica cuidadosa, incluindo a identificação precoce dos sintomas, o manejo apropriado da reidratação e dos desequilíbrios eletrolíticos, e a necessidade de estratégias de prevenção e educação para pacientes e cuidadores. Conclusão: Os sinais e sintomas são consequências da acidose, hiperglicemia, depleção do volume intravascular e perdas eletrolíticas que ocorrem no paciente com a cetoacidose diabética. Apesar dos desafios, é possível melhorar significativamente os desfechos para crianças com CAD através de um diagnóstico precoce, tratamento eficaz e estratégias de prevenção. Sublinha-se a necessidade de pesquisa contínua para aprimorar as diretrizes de tratamento e de educação para profissionais de saúde, pacientes e suas famílias.
PERFIL DE INTERNAÇÃO DE PACIENTES ADULTOS E IDOSOS COM CISTITE EM SANTA CATARINA, 2018-2023: RETRATO DE UM SEXÉNIO
Authors: Ikeda Augusto Kenzo Colombo , Lunelli Laura , Câmara Hanna Lamim , Faria Lucas Henrique Silva de , Silva Madrine Guimarães da 
Published: April 2024

OBJETIVO: Descrever o perfil epidemiológico das internações por cistite na população adulta e idosa de Santa Catarina. METODOLOGIA: Foi realizado um estudo ecológico transversal, com dados secundários, obtidos do Sistema de Informações Hospitalares disponibilizado pelo DATASUS, uma plataforma online com acesso público que disponibiliza as informações no TABNET. No estudo foram incluídas as internações hospitalares por cistite na região Sul do Brasil, a partir de 30 anos de idade, ocorridas no período de 2018 a 2023. RESULTADOS: No período de 2018-2023 foram analisados 4.173 casos de internação por cistite em Santa Catarina. No recorte temporal percebe-se uma regularidade do número de casos, onde a maior diferença numeral está no ano de 2019 e 2020, no qual 2019 obteve 785 (18,81%) internações por cistite e seu ano seguinte 589 (14,11%), apresentando uma redução de 4,7%, ou 196 casos em um ano. Destacando, em Santa Catarina, um padrão crescente em relação à faixa etária de 50 a 59 anos , 60 a 69 anos , 70 a 79 anos e 80 ou mais anos, sendo apenas a faixa etária de 40 a 49 anos que apresentou redução nas internações comparando com a última década. CONCLUSÕES: Em face do exposto acerca do perfil dos pacientes internados com cistite em Santa Catarina, notam-se idade e sexo feminino como fatores predisponentes para o desenvolvimento de cistite, demandando uma atenção dos órgãos públicos para um aperfeiçoamento da prevenção nesses grupos.
SOSIALISASI DAN PELATIHAN MENGANYAM SERAT ALAM UNTUK PENGUAT PADA TEKNOLOGI TEPAT GUNA BIOKOMPOSIT TERMOPLASTIK DAUR ULANG SAMPAH PLASTIK SEBAGAI BAHAN BAKU KERAJINAN TANGAN DI DESA GADOBANGKONG, NGAMPRAH, KABUPATEN BANDUNG BARAT
Authors: Banowati Lies , R Rukmana Asep , Susilawati Endang , Mulyati Budi 
Published: April 2024

Gadobangkong adalah desa di Kecamatan Ngamprah, Kabupaten Bandung Barat, Jawa Barat yang mempunyai visi yaitu terwujudnya masyarakat desa yang cerdas, berakhlak mulia, mandiri, dan sejahtera yang dilandasi ilmu pengetahuan dan teknologi dengan melaksanakan pembangunan yang berwawasan lingkungan. Kegiatan pengabdian masyarakat di desa Gadobangkong untuk mensolusi masalah keterbatasan pengetahuan dan keterampilan pengaplikasian serat biomassa atau serat alam yang ketersediannya melimpah namun belum didayagunakan secara maksimal. Tujuan pengabdian masyarakat adalah mengaplikasikan hasil riset penulis mengenai teknologi tepat guna biokomposit termoplastik serat alam berkelanjutan untuk masyarakat desa. Pelatihan dan bimbingan teknis oleh tim pelaksana kepada mitra mengenai menganyam atau menyusun serat biomassa yang akan digunakan sebagai penguat pada biokomposit termoplastik kepada mitra. Dengan mentransfer teknologi pada kegiatan Pengabdian Kepada Masyarakat ini diharapkan implementasi teknologi bermanfaat untuk meningkatkan nilai jual serat biomassa untuk diaplikasikan sebagai penguat pada biokomposit termoplastik dengan pengikat daaur ulang sampah plastik yang telah diolah menjadi serpih plastik. Hasil pengabdian masyarakat adalah kerajinanan tangan tatakan gelas berbahan baku bikomposit termoplastik penerapan teknologi tepat guna komposit untuk meningkatnya pengetahuan masyarakat mengenai teknologi tepat guna yang dilakukan melalui pelatihan ke mitra masyarakat ibu PKK, pemulung sampah plastik, karang taruna di desa Gadobangkong, Ngamprah, Kabupaten Bandung Barat.
PENGGUNAAN INDIKATOR MYERS-BRIGGS TYPE INDICATOR (MBTI) UNTUK PENEMPATAN KARYAWAN MEMANFAATKAN SISTEM PAKAR METODE FORWARD CHAINING
Authors: Ikhram Faisal , Ramsari Nopi 
Published: April 2024

Penempatan karyawan merupakan bagian dari tugas fungsi Manajemen Sumber Daya Manusia. Penempatan pada bidang kerja yang tepat dan sesuai dengan bakat dan kepribadian karyawan, akan mampu meningkatkan motivasi, produktivitas dan kepuasan kerja. Model indicator Myers Briggs Type Indicator (MBTI), yang membagi preferensi kepribadian manusia menjadi 16 tipe, dapat digunakan sebagai dasar menentukan penempatan Karyawan. Penelitian ini bertujuan menawarkan cara menentukan posisi karyawan yang sesuai dengan bakat dan kepribadiaannya menggunakan aplikasi sistem pakar. Sistem Pakar dalam penelitian ini menggunakan metode penalaran Forward Chaining yang mana pengguna memilih fakta yang sesuai terlebih dahulu, lalu dibuat konklusi atas fakta yang telah dipilih sebelumnya. Hasil penelitian mempermudah akses bagi pimpinan yang ingin melakukan tes kepribadian karyawannya dan mengurangi biaya, karena tes kepribadian dapat dilakukan tanpa menghadirkan seorang pakar.
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Exploring the dynamics between artificial intelligence and cybersecurity in Healthcare
Authors: Tavares António , Sousa Pedro , Proença Rita 
Published: April 2024

Technology changed the world over the past decades, reinventing the way we work, communicate, and live. In the healthcare sector, it has contributed to driving innovations in the diagnosis process, treatment, data management, and information access. However, this transformation has been accompanied by an increasing dependence on digital systems and connectivity. Nowadays, concepts such as artificial intelligence and cybersecurity are widely recognized, but organizations just became aware of the benefits and risks involved. In fact, the nature of their relationship it is still under discussion.
The central objective of this study is to explore the dynamics of this relationship in healthcare, taken as a sector undergoing constant technological evolution. We propose a dual approach, encompassing both strategic and operational perspectives, which can support the management of this complex interaction, balancing security and innovation.