bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chlamydophila psittaciis viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: Results of a single‐center prospective case–control study
Authors: Ferreri Andrés J.M. , Dolcetti Riccardo , Dognini Giuseppina P. , Malabarba Lucia , Vicari Nadia , Pasini Elisa , Ponzoni Maurilio , Cangi Maria Giulia , Pecciarini Lorenza , Resti Antonio Giordano , Doglioni Claudio , Rossini Silvano , Magnino Simone 
Published: June 2008

AbstractOcular adnexal MALT lymphoma (OAML) is linked toChlamydophila psittaci (Cp) infection. Viability and infectivity ofCp, demonstrated by growth in culture, has not been yet investigated in these patients. We conducted a single‐center prospective case–control study to assess the prevalence, viability and infectivity ofCpin 20 OAML patients and 42 blood donors registered in a 6‐month period. The presence ofCpin conjunctival swabs and peripheral blood mononuclear cells (PBMC) of patients and donors was assessed by TETR‐PCR andin vitrocultures. From an epidemiological point of view, OAML patients often resided in rural areas, and reported a history of chronic conjunctivitis and prolonged contact with household animals (85%vs. 38% of donors;p= 0.00001).Cpwas detected in lymphoma tissue in 15 (75%) patients.CpDNA was detected in conjunctival swabs and/or PBMC from 10 (50%) patients and in PBMC from 1 (2%) donor (p= 0.01). Viability and infectivity ofCp, demonstrated by growth in culture, were confirmed in conjunctival swabs and/or PBMC from 5 (25%) patients, but not in donors (p= 0.002). This prospective study demonstrates, for the first time, thatCppresent in the conjunctiva and PBMC of OAML patients is capable to grow and be isolated in cell cultures.Cpinfection is common in OAML patients and exceptional in blood donors. Epidemiological data of OAML patients (prolonged contact with household animals and chronic conjunctivitis) are consistent withCpexposure risk. © 2008 Wiley‐Liss, Inc.
HMG‐CoA reductase expression in breast cancer is associated with a less aggressive phenotype and influenced by anthropometric factors
Authors: Borgquist Signe , Djerbi Soraya , Pontén Fredrik , Anagnostaki Lola , Goldman Malin , Gaber Alexander , Manjer Jonas , Landberg Göran , Jirström Karin 
Published: June 2008

AbstractAlthough several studies have reported on the anti‐tumoural properties exerted by 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMG‐CoAR) inhibitors (statins), the in vivo expression of HMG‐CoAR in human cancer has been considerably less investigated. In our study, we examined the immunohistochemical expression of HMG‐CoAR in 511 incident breast cancers within the Malmö Diet and Cancer Study in order to explore its relationship to established clinicopathological and tumour biological parameters. Furthermore, the potential influence of estrogen exposure on HMG‐CoAR expression was assessed by performing Cox's proportional hazards analyses of the relationship between the use of hormone replacement therapy (HRT), obesity (waist circumference) and tumour‐cell specific HMG‐CoAR expression. We found that HMG‐CoAR was present in various fractions and intensities in the cytoplasm, sometimes with a membranous pattern, but not in the tumour cell nuclei. The expression of HMG‐CoAR was associated with a smaller tumour size (p = 0.02), low histological grade (p = 0.001), low Ki67 index (p = 0.004), ERα+ (p = 0.02), ERβ+ (p = 0.005), and high p27 expression (p = <0.001). The incidence of tumours with a high HMG‐CoAR‐expression was increased among HRT‐users, although this was not statistically significant in a heterogeneity analysis. Obesity was significantly associated with a high HMG‐CoAR expression assessed both as a high (>50%) fraction of positive cells (relative risk: 2.06; 95% confidence interval: 1.20–3.51), and a strong staining intensity (2.33: 1.08–5.02). In summary, we demonstrate that HMG‐CoAR is differentially expressed in breast cancer and that a high expression is associated with prognostically favourable tumour parameters. Moreover, estrogen related life‐style and anthropometric factors might indeed regulate HMG‐CoAR expression. © 2008 Wiley‐Liss, Inc.
Angiotensin II‐dependent loss of cardiac function: Mechanisms and pharmacological targets attenuating this effect
Authors: Mufti Solaiman , Wenzel Sibylle , Euler Gerhild , Piper Hans Michael , Schlüter Klaus‐Dieter 
Published: June 2008

AbstractPharmacological inhibition of components of the renin‐angiotensin‐system is one of the major therapeutically options to treat patients with heart failure. This study hypothesized that angiotensin II (Ang II) directly depresses contractile function (cell shortening) by activation of transforming growth factor‐β1 (TGF‐β1). Moreover, we hypothesized that an inhibition of glycogen synthase kinase 3‐βGSK will compensate for this depressive effect by increasing SERCA2 expression. Isolated adult ventricular rat cardiomyocytes were used and cultured in the presence of Ang II (100 nM) for 24 h. Cell shortening and contractile dynamics were recorded at 2 Hz. Immunoblot techniques and gel mobility shift assays were used to demonstrate NFAT activation caused by inhibition of GSK and to demonstrate increases in the expression of SERCA2. Ang‐II caused a nearly 20% decrease in cell shortening. This Ang II‐dependent effect was mimicked by TGF‐β1 (10 ng/ml), attenuated by addition of aprotinin, that was used to block the proteolytic activation of TGF‐β1, or by application of a neutralizing antibody directed against TGF‐β1. Inhibition of GSK activated NFAT, increased SERCA2 expression and improved cell function. In conclusion, the study identified a paracrine mechanism for the Ang II‐dependent loss of cardiac function that occurs independently of hemodynamic changes. Furthermore, it characterized the differences between Ang II and α‐adrenoceptor stimulation with respect to the maintenance of cellular function explaining cellular events contributing to the difference between adaptive (physiological) and mal‐adaptive (patho‐physiological) hypertrophy. J. Cell. Physiol. 217: 242–249, 2008. © 2008 Wiley‐Liss, Inc.
Surface modification of titanium dioxide nanoparticles by polyaniline via an in situ method
Authors: Li Xueyan , Wang Desong , Luo Qingzhi , An Jing , Wang Yanhong , Cheng Guoxiang 
Published: June 2008

AbstractBACKGROUND: Nanoparticulate titanium dioxide (TiO2) has the advantages of high chemical stability, high photocatalytic activity to oxidise pollutants in air and water, relatively low price and non‐toxicity. However, its high surface energy leads to the aggregation of nanoparticles. In addition, the wide band gap of TiO2 (3.2 eV) only allows it to absorb ultraviolet (UV) light (<387 nm), which represents just a small fraction (3–5%) of the solar photons. These factors have limited its use in many fields. In this study, nanoparticulate TiO2 was modified by polyaniline (PANI) in order to enhance its photoactivity under UV light and sunlight illumination.RESULTS: TiO2 nanoparticles were modified by PANI via a chemical oxidative method. The introduction of small amounts of PANI enhanced the dispersion of TiO2 nanoparticles and improved the photocatalytic activity under UV light. In addition, the band gap energies of all PANI/TiO2 nanocomposites were lower than that of neat TiO2 nanoparticles, so the PANI/TiO2 nanocomposites can be excited to produce more electron–hole pairs under sunlight, which could result in higher photocatalytic activities.CONCLUSION: The modification of nanoparticulate TiO2 by PANI can increase its photoactivity in the process of phenol degradation under UV light and sunlight illumination. Copyright © 2008 Society of Chemical Industry
A new austenitic alumina forming alloy: an aluminium‐coated FeNi32Cr20
Authors: Hattendorf H. , Hojda R. , Naumenko D. , Kolb‐Telieps A. 
Published: June 2008

AbstractThe FeCrAl alloys owe their low oxidation rate to the formation of a slow growing α‐aluminium oxide scale. Therefore they are used, for example, as a substrate material in metal‐supported automotive catalytic converters. Increasing exhaust gas temperatures mean that, in addition to the oxidation properties, high temperature mechanical properties should also be improved. Compared to the ferritic FeCrAl alloys, austenitic alloys possess the required high mechanical strength at higher temperatures. However for most commercially available materials the oxidation resistance is not sufficient due to a low aluminium content. High aluminium contents are avoided in austenitic alloys, since they cause severe workability problems, even at aluminium contents, which are below the necessary amount to get a pure alumina scale. The newly developed material Nicrofer 3220 PAl (coated FeNiCrAl) consists of an austenitic FeNi32Cr20 alloy coated with aluminium on both sides. It combines the outstanding oxidation resistance of an alumina forming FeCrAl alloy with the advantage of the high temperature strength of an austenitic alloy. Additionally the oxidation is even lower than the oxidation of the commercial grade Aluchrom YHf (FeCr20Al6)—conventional homogenous FeCrAl. Aluminium coated FeNiCrAl can easily be formed into its final shape. Prior to service, an in situ heat treatment is recommended in order to optimize the properties.
Effect of manufacturing related parameters on oxidation properties of MCrAlY‐bondcoats
Authors: Subanovic M. , Sebold D. , Vassen R. , Wessel E. , Naumenko D. , Singheiser L. , Quadakkers W. J. 
Published: June 2008

AbstractThe effect of MCrAlY‐bondcoat manufacturing parameters prior to TBC deposition on the bondcoat oxidation behavior and TBC lifetime was studied. The studied material was a NiCoCrAl(Y/Hf) free‐standing coating. It was found that variation of oxygen partial pressure during vacuum plasma spraying and the vacuum heat treatment procedure significantly affects the yttrium and hafnium distribution in the coating. In coatings sprayed at high pO2, yttrium and hafnium were mainly tied up into oxide precipitates. This effect is apparently responsible for an early alumina scale spallation and failure of the initially studied TBC system during cyclic oxidation. In contrast, the coating sprayed at low pO2 revealed an overdoping effect, i.e. extensive yttrium and hafnium incorporation into the scale resulting in an accelerated scale growth rate and internal oxidation. It was shown that by variation of the vacuum heat treatment parameters the yttrium and hafnium distribution in the near‐surface regions of the low oxygen coating can be modified. The latter result demonstrates the potential of minimizing the negative overdoping effect on the scale growth in the thermal‐sprayed MCrAlY coatings with low oxygen and/or high reactive element contents by optimization of the vacuum heat treatment procedure.
‘Click’ Chemistry in Polymer and Material Science: An Update
Authors: Binder Wolfgang H. , Sachsenhofer Robert 
Published: June 2008

AbstractThe metal catalyzed azide/alkyne ‘click’ reaction (a variation of the Huisgen 1,3‐dipolar cycloaddition reaction between terminal acetylenes and azides) has vastly increased in broadness and application in the field of polymer science. Thus, this reaction represents one of the few universal, highly efficient functionalization reactions, which combines both high efficiency with an enormously high tolerance of functional groups and solvents under highly moderate reaction temperatures (25–70 °C). The present review assembles an update of this reaction in the field of polymer science (linear polymers, surfaces) with a focus on the synthesis of functionalized polymeric architectures and surfaces.magnified image
Levodopa therapy in a Lesch‐Nyhan disease patient: Pathological, biochemical, neuroimaging, and therapeutic remarks
Authors: Serrano Mercedes , Pérez‐Dueñas Belen , Ormazábal Aida , Artuch Rafael , Campistol Jaume , Torres Rosa J. , García‐Cazorla Angels 
Published: June 2008

AbstractLesch‐Nyhan disease (LND) is a hereditary disorder of purine metabolism causing severe neurobehavioral disturbances in which an abnormal central nervous system dopaminergic function has been implied. However, levodopa treatment has rarely been used, and reports describe heterogeneous responses. We report an LND patient with low dopamine metabolite values in cerebrospinal fluid for whom early levodopa/carbidopa therapy was begun with a notable clinical improvement. We propose that very early treatment of LND patients with levodopa may improve their neurological symptoms and may contribute to a better outcome. © 2008 Movement Disorder Society
DOSY technique applied to palladium nanoparticles in ionic liquids
Authors: Durand Jérôme , Fernández Fernando , Barrière Clément , Teuma Emmanuelle , Gómez Kerman , González Gabriel , Gómez Montserrat 
Published: June 2008

AbstractMultinuclear (1H, 31P, 19F and 11B) diffusion ordered spectroscopy (DOSY) technique has been applied to palladium nanoparticles systems dispersed in ionic liquids (ILs). Even if the nanoparticles themselves cannot be detected through NMR, observation of the solvent (methanol) and the IL ([BMI][PF6] or [BMI][NTf2]), their diffusion coefficients and their changes in the presence of nanoparticles allow us to draw significant assumptions about the organisation of palladium nanoparticles in the IL. For comparison, the corresponding molecular precursors ([PdCl2(cod)] or [Pd2(dba)3]) have been also studied. Copyright © 2008 John Wiley & Sons, Ltd.
Multi‐nuclear magnetic resonance study of Na3AlF6AlPO4 molten and solidified mixtures
Authors: Keppert M. , Rakhmatullin A. , Simko F. , Deschamps Michael , Haarberg G. M. , Bessada C. 
Published: June 2008

AbstractPhosphorus is one of the predominant impurities in the Hall–Heroult process for industrial aluminium production. The nature of the dissolved phosphorus species in the Na3AlF6AlPO4 system has been investigated by in situ high‐temperature (HT) 19F, 23Na, 27Al, 17O, and 31P NMR. The combination of these experiments enables to define the presence of PO43−, AlF52− and (AlF4OPO3)4− anions in the melt, and then the formation of AlOP bonding. Melts solidified at different cooling rates were characterised using various solid‐state NMR techniques including multiple quantum magic angle spinning (MQMAS), rotational echo double resonance (REDOR) and heteronuclear single quantum correlation (HSQC). The glass obtained by the rapid quenching of the hypereutectic melt has been carefully described in order to better understand the structure of the melt. Copyright © 2008 John Wiley & Sons, Ltd.
Factors that affect the optimal amount of central control in complex systems
Authors: Solow Daniel , Szmerekovsky Joseph 
Published: June 2008

AbstractWhereas much of the previous research in complex systems has focused on emergent properties resulting from self‐organization of the individual agents that make up the system, this article studies one vital role of central organization. In particular, four factors are conjectured to be key in determining the optimal amount of central control. To validate this hypothesis, these factors are represented as controllable parameters in a mathematical model. For different combinations of parameter values, the optimal amount of central control is found, either analytically or by computer simulation. The model is shown to provide results that match well with the level of control found across a broad spectrum of specific complex systems. This model also provides general guidelines as to how combinations of these factors affect the desirable level of control and specific guidelines for selecting and evaluating leaders. These results indicate that all of these factors, though not exhaustive, should be considered carefully when attempting to determine the amount of control that is best for a system. © 2008 Wiley Periodicals, Inc. Naval Research Logistics, 2008
Towards Standard Protocols and Guidelines for Urine Proteomics: A Report on the Human Kidney and Urine Proteome Project (HKUPP) Symposium and Workshop 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA
Authors: Yamamoto Tadashi , Langham Robyn G. , Ronco Pierre , Knepper Mark A. , Thongboonkerd Visith 
Published: June 2008

AbstractThe Human Kidney and Urine Proteome Project (HKUPP) was initiated in 2005 to promote proteomics research in the nephrology field, to better understand kidney functions as well as pathogenic mechanisms of kidney diseases, and to define novel biomarkers and therapeutic targets. This project was first approved in 2005 by the Human Proteome Organisation (HUPO) as a Kidney Disease Initiative under an umbrella of the HUPO Disease Biomarker Initiative (DBI), and more recently was approved as the HKUPP Initiative in 2007. Several sub‐projects have been planned to achieve the ultimate goals. The most pressing is the establishment of “standard protocols and guidelines for urine proteome analysis”. This sub‐project had been extensively discussed during the first HKUPP symposium (during 6th HUPO Annual World Congress – October 2007, Seoul, Korea) and second workshop (during 40th American Society of Nephrology Renal Week – November 2007, San Francisco, CA, USA). Additional data and references have been collected after the symposium and workshop. An initial draft of standard protocols and guidelines for proteome analysis of non‐proteinuric urine (urine protein excretion ≤150 mg/day) will soon be released as the first HKUPP product.
Robust monotone gradient‐based discrete‐time iterative learning control
Authors: Owens D. H. , Hatonen J. J. , Daley S. 
Published: June 2008

AbstractThis paper considers the use of matrix models and the robustness of a gradient‐based iterative learning control (ILC) algorithm using both fixed learning gains and nonlinear data‐dependent gains derived from parameter optimization. The philosophy of the paper is to ensure monotonic convergence with respect to the mean‐square value of the error time series. The paper provides a complete and rigorous analysis for the systematic use of the well‐known matrix models in ILC. Matrix models provide necessary and sufficient conditions for robust monotonic convergence. They also permit the construction of accurate sufficient frequency domain conditions for robust monotonic convergence on finite time intervals for both causal and non‐causal controller dynamics. The results are compared with recently published results for robust inverse‐model‐based ILC algorithms and it is seen that the algorithm has the potential to improve the robustness to high‐frequency modelling errors, provided that resonances within the plant bandwidth have been suppressed by feedback or series compensation. Copyright © 2008 John Wiley & Sons, Ltd.
Soybean proteins in prudent‐diet foods
Authors: Hamdy M. M. 
Published: June 2008

AbstractA review is presented on soybean proteins and their health, nutritional, convenience, stability, and economic attributes that justify usage in prudent‐diet foods. The concept of these foods is discussed with consideration the contributions of soybean proteins to caloric energy, ratios of polyunsaturated to saturated fatty acid, ratios of polyunsaturated to saturated fatty acids, cholesterol, sodium ion, and levels of sugars. Soybean proteins provide technologists with a cheap, functional protein source for developing meat analogs. Inherent soybean flavors are considered the major unstabilizing problem in prudendiet foods. The energy requirement for producing one pound of meat analog is estimated at 12,300 BTU; soy flour used in it requires only 330 BTU, while cooked meat requires approximately 52,250 BTU per pound.
Chemical, functional, and nutritional properties of sunflower protein products
Authors: Sosulski F. , Fleming S. E. 
Published: June 2008

AbstractSunflower flours and protein concentrates have potential food uses because of their high protein content, white color, bland flavor, and absence of antinutritive factors. Procedures have been developed for removal of chlorogenic acid which forms green and brown colors under alkaline pH, and selection for low chlorogenic acid cultivars is underway in plant breeding programs. Further research is needed on dehulling techniques and possible problems associated with high levels of sugars in sunflower flour. Sunflower flours and concentrates have excellent fat absorption, oil emulsification, and whipping properties. Wieners supplemented with sunflower products showed low shrinkage during the smokehouse treatment and low cooking losses due to high fat and water absorptions. Sunflower‐supplemented wieners did score poorly in peelability and organoleptic tests. Sunflower proteins had an excellent amino acid balance except for low lysine content and, in feeding trials with rats, showed high protein efficiency ratios when blended with legume or meat proteins.
Variability in fatty acid composition amongArachis genotypes: A potential source of product improvement
Authors: Worthington R. E. , Hammons R. O. 
Published: June 2008

AbstractResearch on peanut (Arachis hypogeae L.) genotypes has shown a high degree of genetic variability in fatty acid composition. The two major oil fatty acids, oleic and linoleic, range between 36–69% and 14–40%, respectively, and together make up 75–85% of total fatty acids. The very long chain (C20–C24) fatty acids make up 4–9%, palmitic acid 7–13%, and stearic acid 2–5% of total fatty acids. Stability of oil samples as measured by length of autoxidation induction period at 60 C shows variable but statistically significant (P<0.01) correlations with levels of linoleic acid; peanut butter samples show similar patterns of stability. Selection for lower levels of linoleic acid in the development of new varieties of peanuts should results in products with significantly improved shelf life. Some genotypes show consistent differences in oil stability patterns that are not related to oil linoleic acid content. Analysis of entries from 16 wildArachis species collections revealed levels of oil linoleic acid higher than those found inA. hypogaea. One species,A. villosulicarpa, contained 49% linoleic acid and 21% very long chain acids. The range in linoleic acid withinA. hypogaea and availability of suitable techniques for measuring selection progress give scope for product improvement through breeding.
Evaluation of the food use potential of sixteen varieties of cottonseed
Authors: Lawhon J. T. , Cater C. M. , Mattil K. F. 
Published: June 2008

Abstract and SummarySixteen new or experimental varieties of cotton‐seed, eight glandless and eitht glanded, were extensively analyzed in this study. Ginned seed from each were studied and then kernel samples and finally oil and flour samples prepared from the kernels. Mean values determined for each attribute measured are presented for each type seed. These data are useful for (a) showing the magnitude of particular desirable properties presently being achieved in varieties of each type seed, (b) showing something of the variation of these properties among varieties within seed types, and (c) comparing glandless and glanded seed types for compositional differences.
Comparison of ultracentrifugal stability parameters with long‐term shelf stability of emulsions
Authors: Vold Robert D. , Acevedo Milagros C. 
Published: June 2008

Abstract and SummaryThe validity of prediction of shelf stability from ultracentrifugal parameters determined on newly prepared Nujol‐in‐water emulsions stabilized with sodium dodecylsulfate (0.2 to 0.4%), cetylpyridiniumchloride (0.1 to 0.2%), Triton X‐100 (0.08 to 0.4%), or Tween 20 (0.08 to 0.4%) was tested by allowing samples to age for periods up to 3 yr. They were then reexamined visually, and an empirical rating scheme devised for describing their stability semiquantitatively. In some cases it was also possible to redetermine the ultracentrifugal parameters on the aged emulsions. None of the ultracentrifugal parameters of the fresh emulsions predicted the order of actual shelf stability correctly in all cases. Possible reasons for the discrepancies are discussed.