bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culprit Lesion Coronary Intervention Before Complete Angiography in ST-Elevation Myocardial Infarction
Authors: Levi Nir , Wolff Rafael , Jubeh Rami , Shuvy Mony , Steinmetz Yoed , Perel Nimrod , Maller Tomer , Amsalem Itshak , Hitter Rafael , Asher Elad , Turyan Anna , Karmi Mohammad , Orlev Amir , Dratva Dmitry , Khoury Zahi , Hasin Tal , Wolak Arik , Glikson Michael , Dvir Danny 
Published: March 2024

ImportanceRapid reperfusion during primary percutaneous coronary intervention (PCI) is associated with improved outcomes among patients with ST-elevation myocardial infarction (STEMI). Although attempts at reducing the time from STEMI diagnosis to arrival at the catheterization laboratory have been widely investigated, intraprocedural strategies aimed at reducing the time to reperfusion are lacking.ObjectiveTo evaluate the effect of culprit lesion PCI before complete diagnostic coronary angiography (CAG) vs complete CAG followed by culprit lesion PCI on reperfusion times among patients with STEMI.Design, Setting, and ParticipantsThis open-label, prospective, randomized clinical trial was conducted between April 1, 2021, and August 31, 2022, among patients admitted to a tertiary center in Jerusalem, Israel, with a diagnosis of STEMI undergoing primary PCI. All patients were followed up for 1 year. Analysis was on an intention-to-treat basis.InterventionPatients were randomized in a 1:1 ratio to undergo either culprit lesion PCI before complete CAG or complete CAG followed by culprit lesion PCI.Main Outcomes and MeasuresA needle-to-balloon time of 10 minutes or less.ResultsA total of 216 patients were randomized, with 184 patients (mean [SD] age, 62.9 [12.2] years; 155 men [84.2%]) included in the final intention-to-treat analysis; 90 patients (48.9%) were randomized to undergo culprit lesion PCI before CAG, and 94 (51.1%) were randomized to undergo to CAG followed by PCI. Patients who underwent culprit lesion PCI before complete CAG had a shorter mean (SD) needle-to-balloon time (11.4 [5.9] vs 17.3 [13.3] minutes; P &amp;lt; .001). The primary outcome of a needle-to-balloon time of 10 minutes or less was achieved for 51.1% of patients (46 of 90) who underwent culprit lesion PCI before CAG and for 19.1% of patients (18 of 94) who underwent complete CAG followed by culprit lesion PCI (odds ratio, 4.4 [95% CI, 2.2-9.1]; P &amp;lt; .001). Rates of adverse events were similar between groups. In a subgroup analysis, the effect of culprit lesion PCI before complete CAG on the primary outcome was consistent. There were no differences in rates of in-hospital, 30-day, and 1-year all-cause mortality.Conclusions and RelevanceIn this randomized clinical trial of patients with STEMI, culprit lesion PCI before complete CAG resulted in shorter reperfusion times. Larger trials are needed to validate these results and to evaluate the effect on clinical outcomes.Trial RegistrationClinicalTrials.gov Identifier: NCT05415085
Phase Engineering on MoS2 to Realize Dielectric Gene Engineering for Enhancing Microwave Absorbing Performance
Authors: Yan Yuefeng , Zhang Kaili , Qin Guangyu , Gao Boshi , Zhang Tao , Huang Xiaoxiao , Zhou Yu 
Published: March 2024

AbstractPolarization relaxation loss caused by defects and interfaces has become a fascinating electromagnetic wave (EMW) loss mechanism. However, the logical relationship between impedance matching and various loss mechanisms requires further elucidation to facilitate more comprehensive and in‐depth research. Herein, phase engineering on molybdenum disulfide (MoS2) is proposed as the main controller of permittivity, offering a straightforward and highly effective method for regulating permittivity. Through the main control of phase engineering, a small gradient, monotonic change of the permittivity across a substantial area is achieved, leading to the gradual transition of the material system from strong loss but impedance mismatching to weak loss but EMW transparent phase. Thanks to the fundamental regulation of impedance characteristic and attenuation capacity by the dielectric gene engineering controlled by the phase engineering, combined with the ingenious coordination of sulfur vacancy‐induced polarization and interfacial polarization, t‐60 harvests an effective absorption band of 6.8 GHz and a minimum reflection loss of −59.8 dB. This study effectively expands the dielectric gene pool and improves the research logic for various loss mechanisms, offering valuable insights for the development of advanced EMW absorbing materials.
Quantum Dot Modification of Large Area Graphene Surfaces via Amide Bonding
Authors: Neubert T. J. , Rösicke F. , Hinrichs K. , Nickel N. H. , Rappich J. 
Published: March 2024

AbstractLarge‐area graphene grown by chemical vapor deposition is functionalized by p‐aminophenyl groups via the diazonium‐route. Subsequently, carboxylic acid‐modified CdSXSe1‐X/ZnS dots (QDs) with maximum emission wavelengths of 540 nm and 630 nm are immobilized via amidation reaction to the amino‐functionalized graphene on the copper growth substrate forming stable covalent bonds in all functionalization steps. After immobilization of the QDs, the functional QD/graphene stack is available for transfer from the growth substrate onto any other substrate. In this study, the QD‐modified graphene is transferred to a Si wafer with surface oxide without losing the QD modification. The successful binding of the QDs onto the functionalized graphene is characterized by their vibrational signature using Raman backscattering and infrared‐spectroscopic ellipsometry and by their specific light emission as measured by photoluminescence (PL) spectroscopy.
Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses
Authors: Vladimir de la Rosa Juan , Tabraue Carlos , Huang Zhiqiang , Orizaola Marta C. , Martin‐Rodríguez Patricia , Steffensen Knut R. , Zapata Juan Manuel , Boscá Lisardo , Tontonoz Peter , Alemany Susana , Treuter Eckardt , Castrillo Antonio 
Published: March 2024

AbstractMacrophages regulate essential aspects of innate immunity against pathogens. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. The liver X receptors (LXRα, LXRβ) are ligand‐dependent nuclear receptors that direct gene expression important for cholesterol metabolism and inflammation, but little is known about the individual roles of LXRα and LXRβ in antimicrobial responses. Here, the results demonstrate that induction of LXRα transcription by prolonged exposure to lipopolysaccharide (LPS) supports inflammatory gene expression in macrophages. LXRα transcription is induced by NF‐κB and type‐I interferon downstream of TLR4 activation. Moreover, LPS triggers a reprogramming of the LXRα cistrome that promotes cytokine and chemokine gene expression through direct LXRα binding to DNA consensus sequences within cis‐regulatory regions including enhancers. LXRα‐deficient macrophages present fewer binding of p65 NF‐κB and reduced histone H3K27 acetylation at enhancers of secondary inflammatory response genes. Mice lacking LXRα in the hematopoietic compartment show impaired responses to bacterial endotoxin in peritonitis models, exhibiting reduced neutrophil infiltration and decreased expansion and inflammatory activation of recruited F4/80lo‐MHC‐IIhi peritoneal macrophages. Together, these results uncover a previously unrecognized function for LXRα‐dependent transcriptional cis‐activation of secondary inflammatory gene expression in macrophages and the host response to microbial ligands.
Biocompatible Cu/NiMo Composite Electrocatalyst for Hydrogen Evolution Reaction in Microbial Electrosynthesis; Unveiling the Self‐Detoxification Effect of Cu
Authors: Moon Byeong Cheul , Kim Soyoung , Jo Young Yoon , Park Jong Hyeok , Ko Ja Kyong , Lee Dong Ki 
Published: March 2024

AbstractH2‐driven microbial electrosynthesis (MES) is an emerging bioelectrochemical technology that enables the production of complex compounds from CO2. Although the performance of microbial fermentation in the MES system is closely related to the H2 production rate, high‐performing metallic H2‐evolving catalysts (HEC) generate cytotoxic H2O2 and metal cations from undesirable side reactions, severely damaging microorganisms. Herein, a novel design for self‐detoxifying metallic HEC, resulting in biologically benign H2 production, is reported. Cu/NiMo composite HEC suppresses H2O2 evolution by altering the O2 reduction kinetics to a four‐electron pathway and subsequently decomposes the inevitably generated H2O2 in sequential catalytic and electrochemical pathways. Furthermore, in situ generated Cu‐rich layer at the surface prevents NiMo from corroding and releasing cytotoxic Ni cations. Consequently, the Cu/NiMo composite HEC in the MES system registers a 50% increase in the performance of lithoautotrophic bacterium Cupriavidus necator H16, for the conversion of CO2 to a biopolymer, poly(3‐hydroxybutyrate). This work successfully demonstrates the concept of self‐detoxification in designing biocompatible materials for bioelectrochemical applications as well as MES systems.
Importance of the biochemical investigations for the functional characterization of a NPC1 variant identified by exome sequencing
Authors: Almenabawy Nihal , Hung Clara , Sosova Iveta , Mercimek‐Andrews Saadet 
Published: March 2024

AbstractNiemann–Pick disease type C (NPC) is one of the lysosomal storage disorders. It is caused by biallelic pathogenic variants in NPC1 or NPC2, which results in a defective cholesterol trafficking inside the late endosome and lysosome. There is a high clinical variability in the age of presentation and the phenotype of this disorder making the diagnosis challenging. Here, we report a patient with an infantile onset global developmental delay, microcephaly and dysmorphic features, homozygous for c.3560C>T (p.A1187V) variant in NPC1. His plasma oxysterol levels were normal on two occasions. His lyso‐sphingomyelin‐509 (lyso‐SM 509) and urinary bile acid levels were normal. Based on the phenotype and biochemical features, the diagnosis of NPC was excluded in this patient. We emphasize the importance of functional characterization in the classification of novel variants to prevent a misdiagnosis. Matching the phenotype and biochemical evidence with the molecular genomic tests is crucial for the confirmation of genetic diagnoses.
A case report of multicentric carpotarsal osteolysis syndrome: Depiction of a debilitating disease course
Authors: Li Jennifer Yee‐ming , Ho Fanny Tsz‐wai , Lee Mianne , Chan Joyce , Chung Brian Hon‐yin , Tung Joanna Yuet‐ling , Ma Alison Lap‐tak 
Published: March 2024

AbstractMulticentric carpotarsal osteolysis syndrome (MCTO) is a rare skeletal disorder characterized by progressive osteolysis involving the carpal and tarsal bones, and often associated with nephropathy. It is caused by heterozygous mutation in the MAF bZIP transcription factor B (MAFB) gene. Heterogeneous clinical manifestation and wide spectrum of disease severity have been observed in patients with MCTO. Here, we report a case of a male patient who presented with kidney failure in childhood with progressive disabling skeletal deformity. He was diagnosed with MCTO at 31‐years‐old, where a de novo pathogenic heterozygous variant in NM_005461.5:c.212C>A: p.(Pro71His) of the MAFB gene was identified. While there has been little data on the long‐term prognosis and life expectancy of this disease, this case report sheds light on the debilitating disease course with multiple significant morbidities of a patient with MCTO throughout his lifetime of 33 years.
Waterborne polyurethane polymer dispersions using castor oil and curcumin as bioresources: Synthesis, characterization, and antibacterial textile applications
Authors: Ganvit Vikash M. , Bhandari Parthik D. , Kunjadiya Anju , Mansuri Jasmine , Bambhaniya Sanjay B. , Mandot Aadhar A. , Sharma Rakesh K. 
Published: March 2024

AbstractThe main goal of this study is to make new waterborne polyurethane polymers (WPUCs) using bioresources like curcumin as a chain extender and castor oil as a polyol. We explored different mole ratios of curcumin during the synthesis of WPUC polymers. The WPUC dispersions were well‐defined and had nanoparticle sizes that ranged from 80.1 to 48.2 nm. Their zeta potentials were between −61.7 and − 52.2 mV, which showed that they were more stable. The absence of a phenolic hydroxyl band in the synthesized WPUC's IR spectrum indicated the insertion of curcumin into the PU chain. The coating of WPUCs on polyester/cotton (PE/C) blend fabric showed an improvement in colorfastness properties and reduced air permeability. The enhanced bending modulus (enhanced stiffness), improved abrasion resistance, and higher tensile strength were also observed. Furthermore, the WPUC‐coated fabric samples showed a bacterial inhibition percentage of 83.12%–99.9999% (p < 0.001) compared with blank fabric against bacterias' because of the inherent nature of curcumin. Inserting a higher amount of curcumin in the polymer chain of WPUC improved the antibacterial effects. Overall, our findings provide valuable insights for the possible antibacterial textile applications of synthesized WPUCs.
Output synchronization for multi‐agent systems with prescribed performance in the presence of unknown control directions
Authors: Peng Junmin , Wang Kaining , Li Jianbo , Li Chaoyong , Xiao Shenping 
Published: March 2024

AbstractIn this paper, we investigate the output synchronization for multiple parametric strict feedback (PSF) systems with unknown control directions. Toward this, prescribed performance control is applied, that is, both transient and steady‐state properties are guaranteed simultaneously by the recursively designed controller. It is different from existing studies, mainly in the following points: (1) The dynamic of each agent has multiple unknown control directions; (2) the neighborhood error not only evolves within the specified boundaries but also converges to zero ultimately; and (3) there is no leader in the digraph. The effectiveness of the proposed controller is verified by theoretical analysis and numerical simulation example of the vessels.
Conceptualizing employees' behavioral pattern changes by experiencing customer mistreatment: Integrating moral self‐regulation and dual process model perspectives
Authors: Song Young Ho 
Published: March 2024

AbstractThis conceptual paper has two aims. The first is to explain how frontline employees' workplace sabotage initially occurs when frontline employees experience perceived mistreatment from customers. Moral outrage arises among frontline employees and mediates the relationship between customer mistreatment and workplace sabotage. The second aim is to address changes in frontline employees' behavioral patterns during working hours. Initial negative workplace behaviors (workplace sabotage) are more likely to shift to good behavior (organizational citizenship behavior toward customer; OCB‐customer) due to a need for moral cleansing, but will eventually revert to negative behaviors (additional workplace sabotage) as continuous customer mistreatment increases stress. To understand this process, moral‐self regulation theory and the dual process model are introduced to support the conceptual model. Implications and future research directions are also discussed.
Tellurium Containing Long Lived Emissive Fluorophore for Selective and Visual Detection of Picric Acid through Photo‐Induced Electron Transfer
Authors: Banerjee Bhaskar , Ali Afsar , Kumar Sandeep , Verma Rajaneesh Kumar , Verma Vinay Kumar , Singh Ram Chandra 
Published: March 2024

AbstractA novel tellurium (Te) containing fluorophore, 1 and its nickel (2) and copper (3) containing metal organic complex (MOC) have been synthesized to exploit their structural and optical properties and to deploy these molecules as fluorescent probes for the selective and sensitive detection of picric acid (PA) over other commonly available nitro‐explosives. Furthermore, density functional theory (DFT) and single crystal X‐ray diffraction (SCXRD) techniques revealed the inclusion of “soft” Tellurium (Te) and “hard” Nitrogen (N), Oxygen (O) atoms in the molecular frameworks. Owing to the presence of electron rich “N” and “O” atoms along with “Te” in the molecular framework, 1 could efficiently and selectively sense PA with more than 80 % fluorescence quenching efficiency in organic medium and having detection limit of 4.60 μM. The selective detection of PA compared to other nitro‐explosives follows a multi‐mechanism based “turn‐off” sensing which includes photo‐induced electron transfer (PET), electrostatic (π‐π stacking and π‐anion/cation) interaction, intermolecular hydrogen bonding and inner filter effect (IFE). The test strip study also establishes the sensitivity of 1 for detection of PA.
Prognostic impact of frailty based on a comprehensive frailty assessment in patients with heart failure
Authors: Hamada Tomoyuki , Kubo Toru , Kawai Kazuya , Nakaoka Yoko , Yabe Toshikazu , Furuno Takashi , Yamada Eisuke , Kitaoka Hiroaki ,   Kochi YOSACOI study
Published: March 2024

AbstractAimsThis study aimed to evaluate the impact of frailty and living function domains based on the Kihon Checklist (KCL), a questionnaire for a comprehensive frailty assessment, on prognosis in patients with acute heart failure (AHF).Methods and resultsThe Kochi Registry of Subjects with Acute Decompensated Heart Failure (Kochi YOSACOI) study was a prospective multicentre cohort study enrolling 1061 patients hospitalized for AHF from May 2017 to December 2019 in Japan. We divided patients into three groups according to the severity of frailty using the KCL and compared clinical outcomes after discharge. The primary endpoint was all‐cause death, and the secondary outcomes were cardiovascular death, heart failure (HF) rehospitalization, and the composite event of cardiovascular death and HF rehospitalization. Of 936 patients (median age, 81 years; 48.9% women) who could be assessed for frailty, we identified frailty in 501 patients (53.5%), prefrailty in 290 patients (31.0%), and non‐frailty in 145 patients (15.5%). Compared with prefrail and non‐frail patients, frail patients were older (83 vs. 79 and 72 years, P < 0.001), were more likely to be women (53.9% vs. 43.1% and 43.4%, P = 0.005), and were more likely to have a history of previous HF hospitalization (35.4% vs. 25.3% and 19.6%, P < 0.001) and multimorbidity (90.8% vs. 81.0% and 73.8%, P < 0.001). Frail patients had a lower rate of discharge to home (79.7% vs. 94.8% and 96.5%, P < 0.001). During the 2 year follow‐up period, frail patients had a higher incidence rate of all‐cause death, cardiovascular death, and HF rehospitalization (log‐rank P < 0.001, P < 0.001, and P = 0.003, respectively). After adjusting for other prognostic factors, multivariate analysis showed that frailty was associated with all‐cause death [adjusted hazard ratio (HR): 2.917, 95% confidence interval (CI): 1.326–6.417, P = 0.008] and cardiovascular death (adjusted HR: 7.026, 95% CI: 1.700–29.030, P = 0.007). Among all domains of the KCL, the cognitive function domain was associated with a higher risk of all‐cause death (P = 0.004) and cardiovascular death (P < 0.001). The depression domain remained associated with a higher risk of HF rehospitalization (P = 0.045). The risk for all‐cause death increased with an increase in total KCL score (adjusted HR: 1.819, 95% CI: 1.300–2.547, P < 0.001).ConclusionsThe KCL is a useful tool for risk stratification of adverse outcomes in patients with AHF. Functional declines in psycho‐emotional domains including cognitive function and depressed mood contribute to adverse outcomes.
Increased interleukin‐6 is associated with higher risk of heart failure in people with type 2 diabetes
Authors: Remmelzwaal Sharon , Yeung Stanley M.H. , Blom Marieke T. , de Borst Martin H. , Elders Petra J.M. , Beulens Joline W.J. 
Published: March 2024

AbstractAimsWe aimed to determine the association between serum interleukin‐6 (IL‐6) concentrations and new‐onset heart failure (HF) in persons with type 2 diabetes (T2D).Methods and resultsWe performed a case–control study nested in the Diabetes Care System Cohort, a prospective cohort of persons with T2D in primary care. We included 724 participants, of whom 141 developed HF during 5 years of follow‐up and 583 were age‐ and sex‐matched controls. IL‐6 was measured at baseline and categorized into four groups: Group 1 was composed of participants with IL‐6 below the detection limit of 1.5 pg/mL, and the remainder were divided into tertiles. We performed logistic regression analyses with categorized IL‐6 or continuous IL‐6 as the determinant and new‐onset HF as the outcome adjusted for follow‐up time, age, sex, glycated haemoglobin, estimated glomerular filtration rate, albumin/creatinine ratio, and cardiovascular disease at baseline. Effect modification by sex was tested. Participants were 70.7 ± 9.0 years, and 38% were women. In comparison with Group 1, all tertiles were associated with an increased risk of HF with odds ratios of 2.1 [95% confidence interval (CI): 1.2–2.9], 2.8 (95% CI: 2.0–3.7), and 2.1 (95% CI: 1.3–3.0), respectively, for Tertiles 1–3. Continuous IL‐6 was associated with the development of HF with an odds ratio of 1.2 (95% CI: 1.0–1.5). No effect modification by sex was observed.ConclusionsHigher IL‐6 levels are associated with the development of HF in persons with T2D. Further research should determine whether IL‐6‐lowering interventions could prevent the development of HF.
Bimetallic Ru(II) Complex Catalysed β‐Alkylation of Secondary Alcohols and α‐Alkylation of Ketones: Selective Formation of Saturated Ketones
Authors: Deshmukh Gopal , Murugavel Ramaswamy 
Published: March 2024

AbstractRu(II) bimetallic [(p‐cymene)2(RuCl)2L1]2X (X=BF4 (Cat2); X=PF6 (Cat3)) and monometallic [(p‐cymene)(RuCl)L2]BF4 (Cat4) (where L1=N,N’‐(3,3’,5,5’‐tetraisopropyl‐[1,1’‐biphenyl]‐4,4’‐diyl)bis(1‐(pyridin‐2‐yl)methanimine); L2=N‐(2,6‐diisopropyl‐phenyl)‐1‐(pyridin‐2‐yl)‐methanimine) catalyse selective synthesis of saturated ketones using β‐alkylation of secondary alcohol or α‐alkylation of ketones with primary alcohol. Notably, a single catalyst facilitates the oxidation of both secondary and primary alcohols followed by condensation and hydrogenation yielding α‐alkylated saturated ketones. Remarkably, this system allows catalyst loading as low as 0.01 mol% for β‐alkylation of secondary alcohols and 0.005 mol% for the α‐alkylation of ketone, delivering access to a wide array of α‐alkylated ketones derivatives with yields of ~97 %. Complex Cat2, in particular, orchestrates one‐pot alkylation reactions with a high turnover frequency (TOF) of 5.6
105 h−1 using as low as low catalyst loading of 0.0001 mol%. A comparative study between bimetallic and monometallic complexes reveals that complex Cat2 exhibits better selectivity for the formation of saturated ketones presumably owing to a cooperative effect between the metal centres. The scale‐up synthesis highlights the practical applicability of the catalytic approach. To delve into the plausible mechanisms, we conducted initial investigations through meticulously controlled experiments and spectroscopic analysis.