bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of near infra-red laser light increases current threshold in optic nerve consistent with increased Na+-dependent transport
Authors: Lo Hin Heng , Munkongcharoen Tawan , Muijen Rosa M. , Gurung Ritika , Umredkar Anjali G. , Baker Mark D. 
Published: February 2024

AbstractIncreases in the current threshold occur in optic nerve axons with the application of infra-red laser light, whose mechanism is only partly understood. In isolated rat optic nerve, laser light was applied near the site of electrical stimulation, via a flexible fibre optic. Paired applications of light produced increases in threshold that were reduced on the second application, the response recovering with increasing delays, with a time constant of 24 s. 3-min duration single applications of laser light gave rise to a rapid increase in threshold followed by a fade, whose time-constant was between 40 and 50 s. After-effects were sometimes apparent following the light application, where the resting threshold was reduced. The increase in threshold was partially blocked by 38.6 mM Li+ in combination with 5 $$\mu$$
μ
M bumetanide, a manoeuvre increasing refractoriness and consistent with axonal depolarization. Assessing the effect of laser light on the nerve input resistance ruled out a previously suggested fall in myelin resistance as contributing to threshold changes. These data appear consistent with an axonal membrane potential that partly relies on temperature-dependent electroneutral Na+ influx, and where fade in the response to the laser may be caused by a gradually diminishing Na+ pump–induced hyperpolarization, in response to falling intracellular [Na+].
Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis
Authors: Travaglino Antonio , Arciuolo Damiano , Santoro Angela , Fulgione Caterina , Piermattei Alessia , Martinelli Manuela , Onori Maria Elisabetta , Minucci Angelo , Raffone Antonio , Inzani Frediano , Zannoni Gian Franco 
Published: February 2024

AbstractSex cord-like endometrioid carcinoma (SCLEC) is an uncommon entity which may constitute a diagnostic challenge. This study aimed to perform a clinicopathological, immunohistochemical, and molecular reappraisal of ovarian SCLEC. Consecutive ovarian SCLECs cases from a single institution were reviewed during a 13-year period. Twenty-three immunohistochemical markers were tested; 10 genes were analyzed by next-generation sequencing. Nine cases of ovarian SCLEC were identified. Mean patient age was 65.7 years; three cases showed extraovarian extension. Architectural pattern included sertoliform (n = 2), granulosa-like (n = 2), and mixed granulosa-like/sertoliform (n = 5). Eosinophilic changes accompanied by increased nuclear atypia were observed in four tumors. Endometrioid features (glands, squamous/morular differentiation) were observed in six cases. Most tumors were positive for cytokeratin-7 (8/9), EMA (9/9), estrogen and progesterone receptor (9/9), CD10 (7/9, including a luminal pattern reminiscent of mesonephric neoplasms), nuclear β-catenin (8/9), and CDX2 (8/9). A minority of cases showed block-type p16 pattern (2/9), PAX8-positivity (3/9), and non-diffuse positivity for WT1 (1/9), inhibin (1/9), chromogranin (1/9), and synaptophysin (2/9). All cases were negative for GATA3, TTF1, calretinin, and SF1. Ki67 range was 15–90%. Six cases showed CTNNB1 exon 3 mutation. Eight cases were of “no specific molecular profile” (NSMP) and one was p53-abnormal. In conclusion, SCLECs frequently exhibit a mixed sertoliform/granulosa-like architecture and express epithelial markers, hormone receptors, nuclear β-catenin, and CDX2, with luminal CD10 positivity and CTNNB1 mutations. PAX8 expression is often lost, while other mesonephric, sex cord, and neuroendocrine markers are negative.
Long-term mesh-related complications from minimally invasive intraperitoneal onlay mesh for small to medium-sized ventral hernias
Authors: Maskal Sara M. , Ellis Ryan C. , Mali Ouen , Lau Braden , Messer Nir , Zheng Xinyan , Miller Benjamin T. , Petro Clayton C. , Prabhu Ajita S. , Rosen Michael J. , Beffa Lucas R. A. 
Published: February 2024

Abstract
Introduction
Intraperitoneal onlay mesh (IPOM) placement for small to medium-sized hernias has garnered negative attention due to perceived long-term risk of mesh-related complications. However, sparse data exists supporting such claims after minimally invasive (MIS) IPOM repairs and most is hindered by the lack of long-term follow-up. We sought to report long-term outcomes and mesh-related complications of MIS IPOM ventral hernia repairs.

Methods and procedures
Adult patients who underwent MIS IPOM ventral hernia repair at our institution were identified in the Abdominal Core Health Quality Collaborative database from October 2013 to October 2020. Outcomes included hernia recurrence and mesh-related complications or reoperations up to 6 years postoperatively.

Results
A total of 325 patients were identified. The majority (97.2%) of cases were elective, non-recurrent (74.5%), and CDC class I (99.4%). Mean hernia width was 4.16 ± 3.86 cm. Median follow-up was 3.6 (IQR 2.8–5) years. Surgeon-entered or patient-reported follow-up was available for 253 (77.8%) patients at 3 years or greater postoperatively. One patient experienced an early small bowel obstruction and was reoperated on within 30 days. Two-hundred forty-five radiographic examinations were available up to 6 years postoperatively. Twenty-seven patients had hernia recurrence on radiographic examination up to 6 years postoperatively. During long-term follow-up, two mesh-related complications required reoperations: mesh removed for chronic pain and mesh removal at the time of colon surgery for perforated cancer. Sixteen additional patients required reoperation within 6 years for the following reasons: hernia recurrence (n = 5), unrelated intraabdominal pathology (n = 9), obstructed port site hernia (n = 1), and adhesive bowel obstruction unrelated to the prosthesis (n = 1). The rate of reoperation due to intraperitoneal mesh complications was 0.62% (2/325) with up to 6 year follow-up.

Conclusion
Intraperitoneal mesh for repair of small to medium-sized hernias has an extremely low rate of long-term mesh-related complications. It remains a safe and durable option for hernia surgeons.
Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Authors: Nagao Kae , Sakai Arata , Tsumura Hidetaka , Iemoto Takao , Hirata Yuichi , Hori Hitomi , Ogisu Kyohei , Kakuyama Saori , Ikegawa Takuya , Hirata Tamaki , Ezaki Takeshi , Furumatsu Keisuke , Yamanaka Kodai , Kato Takao , Fujigaki Seiji , Tanaka Hidenori , Yagi Yosuke , Tanaka Takeshi , Kobayashi Takashi , Masuda Atsuhiro , Shiomi Hideyuki , Kodama Yuzo 
Published: February 2024

Abstract
Background
Immune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail. We conducted a retrospective multicenter study to determine the clinical characteristics, risk factors, and treatment of ICI-PI.

Methods
We reviewed the medical records of patients who received ICIs for malignant tumors between April 2014 and April 2019 at 16 participating hospitals. Patients with elevated pancreatic enzymes or pancreatitis were identified and classified using the Common terminology Criteria for Adverse Events (CTCAE) ver.5.0). The number of patients with pancreatic enzyme elevation was determined and those with pancreatic enzyme elevation of ≥ grade 3 according to CTCAE ver.5.0, or pancreatitis underwent detailed analysis for ICI-PI.

Results
The study enrolled 1069 patients. Nineteen patients (1.8%) had ICI-PI, 5 (0.5%) of whom also had pancreatitis. Four patients had mild pancreatitis, whereas 1 patient had severe pancreatitis, culminating in death. Steroid therapy was administered to 7 of 19 patients, which led to ICI-PI improvement in 5 patients. On the other hand, ICI-PI improved in 9 of 12 patients who were not administered steroid therapy. Six of the 14 patients with ICI-PI improvement were rechallenged with ICI, and ICI-PI relapse occurred in only 1 patient (16.7%), which improved with ICI discontinuation and steroid therapy.

Conclusions
ICI-PI is a rare occurrence, with a low incidence of pancreatitis, which followed a very serious course in one patient. Although the benefit of steroid therapy for ICI-PI is unclear, ICI rechallenge is acceptable after improvement of ICI-PI without pancreatitis.
Interactive responses to temperature and salinity in larvae of the Asian brush-clawed crab Hemigrapsus takanoi: relevance for range expansion into the Baltic Sea, in the context of climate change
Authors: Geißel Jan Phillipp , Espinosa-Novo Noé , Giménez Luis , Ewers Christine , Cornelius Annika , Martínez-Alarcón Diana , Harzsch Steffen , Torres Gabriela 
Published: February 2024

AbstractWe studied the potential of a recently introduced species, the Asian brush-clawed crab (Hemigrapsus takanoi), to expand its distribution range further into the Baltic Sea. H. takanoi has been documented in the southwestern Baltic Sea since 2014. The ability to persist and further expand into the Baltic Proper will depend on their potential to sustain all stages of their complex life cycle, including pelagic larvae, under the Baltic Sea's conditions. Range limits may be established by the tolerance to low salinity, which in addition may be affected by water temperature. A key question is whether local populations at the distribution limit (within the Baltic Sea) show increased tolerance to low salinities and hence promote further expansion. We quantified the combined effects of salinity (10–33 PSU) and temperature (15–24 °C) on larval development in four populations of H. takanoi (two from the Baltic and two from the North Sea). We found substantial differences in larval performance between the populations from the Baltic and North Seas. Larvae from the North Sea populations always showed higher survival and faster development compared with those from the Baltic Sea. Only weak evidence of elevated tolerance towards low salinity was found in the larvae from the Baltic Sea populations. In addition, larvae from the population located near the range limit showed very low survival under all tested salinity-temperature combinations and no evidence of increased tolerance to low salinity. There was no apparent genetic differentiation among the studied populations in the mitochondrial cytochrome c oxidase subunit one gene (COI) implying high connectivity among the populations. In conclusion, the weak evidence of low salinity tolerance in Baltic Sea populations, and poor larval performance for the population located near the range limit, coupled with limited genetic differentiation suggest that subsidies are needed for populations to persist near the range limit. Alternatively, ontogenetic migrations would be required to sustain those populations. Monitoring efforts are needed to elucidate the underlaying mechanisms and document potential future range expansions.
A unified immersed finite element error analysis for one-dimensional interface problems
Authors: Adjerid Slimane , Lin Tao , Meghaichi Haroun 
Published: February 2024

AbstractIt has been known that the traditional scaling argument cannot be directly applied to the error analysis of immersed finite elements (IFE) because, in general, the spaces on the reference element associated with the IFE spaces on different interface elements via the standard affine mapping are not the same. By analyzing a mapping from the involved Sobolev space to the IFE space, this article is able to extend the scaling argument framework to the error estimation for the approximation capability of a class of IFE spaces in one spatial dimension. As demonstrations of the versatility of this unified error analysis framework, the manuscript applies the proposed scaling argument to obtain optimal IFE error estimates for a typical first-order linear hyperbolic interface problem, a second-order elliptic interface problem, and the fourth-order Euler-Bernoulli beam interface problem, respectively.
Spectral computed tomography angiography using a gadolinium-based contrast agent for imaging of pathologies of the aorta
Authors: Graf Markus , Gassert Felix G. , Marka Alexander W. , Gassert Florian T. , Ziegelmayer Sebastian , Makowski Marcus , Kallmayer Michael , Nadjiri Jonathan 
Published: February 2024

Abstract
Objectives
Especially patients with aortic aneurysms and multiple computed tomography angiographies (CTA) might show medical conditions which oppose the use of iodine-based contrast agents. CTA using monoenergetic reconstructions from dual layer CT and gadolinium (Gd-)based contrast agents might be a feasible alternative in these patients. Therefore, the purpose of this study was to evaluate the feasibility of clinical spectral CTA with a Gd-based contrast agent in patients with aortic aneurysms.

Methods
Twenty-one consecutive scans in 15 patients with and without endovascular aneurysm repair showing contraindications for iodine-based contrast agents were examined using clinical routine doses (0.2 mmol/kg) of Gd-based contrast agent with spectral CT. Monoenergetic reconstructions of the spectral data set were computed.

Results
There was a significant increase in the intravascular attenuation of the aorta between pre- and post-contrast images for the MonoE40 images in the thoracic and the abdominal aorta (p < 0.001 for both). Additionally, the ratio between pre- and post-contrast images was significantly higher in the MonoE40 images as compared to the conventional images with a factor of 6.5 ± 4.5 vs. 2.4 ± 0.5 in the thoracic aorta (p = 0.003) and 4.1 ± 1.8 vs. 1.9 ± 0.5 in the abdominal aorta (p < 0.001).

Conclusions
To conclude, our study showed that Gd-CTA is a valid and reliable alternative for diagnostic imaging of the aorta for clinical applications. Monoenergetic reconstructions of computed tomography angiographies using gadolinium based contrast agents may be a useful alternative in patients with aortic aneurysms and contraindications for iodine based contrast agents.
Lessons Learned from the Updated GEWEX Cloud Assessment Database
Authors: Stubenrauch Claudia J. , Kinne Stefan , Mandorli Giulio , Rossow William B. , Winker David M. , Ackerman Steven A. , Chepfer Helene , Di Girolamo Larry , Garnier Anne , Heidinger Andrew , Karlsson Karl-Göran , Meyer Kerry , Minnis Patrick , Platnick Steven , Stengel Martin , Sun-Mack Szedung , Veglio Paolo , Walther Andi , Cai Xia , Young Alisa H. , Zhao Guangyu 
Published: February 2024

AbstractSince the first Global Energy and Water Exchanges cloud assessment a decade ago, existing cloud property retrievals have been revised and new retrievals have been developed. The new global long-term cloud datasets show, in general, similar results to those of the previous assessment. A notable exception is the reduced cloud amount provided by the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) Science Team, resulting from an improved aerosol–cloud distinction. Height, opacity and thermodynamic phase determine the radiative effect of clouds. Their distributions as well as relative occurrences of cloud types distinguished by height and optical depth are discussed. The similar results of the two assessments indicate that further improvement, in particular on vertical cloud layering, can only be achieved by combining complementary information. We suggest such combination methods to estimate the amount of all clouds within the atmospheric column, including those hidden by clouds aloft. The results compare well with those from CloudSat-CALIPSO radar–lidar geometrical profiles as well as with results from the International Satellite Cloud Climatology Project (ISCCP) corrected by the cloud vertical layer model, which is used for the computation of the ISCCP-derived radiative fluxes. Furthermore, we highlight studies on cloud monitoring using the information from the histograms of the database and give guidelines for: (1) the use of satellite-retrieved cloud properties in climate studies and climate model evaluation and (2) improved retrieval strategies.
Understanding supply-side climate policies: towards an interdisciplinary framework
Authors: Newell Peter , Carter Angela 
Published: February 2024

AbstractOnce marginal in climate governance, supply-side policies which seek to restrict the production of climate warming fossil fuels are now gaining greater prominence. From national level bans and phase out policies to divestment campaigns and the creation of ‘climate clubs’ such as the Beyond Oil and Gas Alliance, an increasing number of such policies are being adopted by governments, cities and financial actors around the world. But why would states voluntarily relinquish potentially profitable reserves of fossil fuels? How can we account for the rise of supply-side policies, the form they take and the sites in which they are being adopted? What conditions and contexts are most conducive to the adoption and sustainability of ‘first mover’ bans and phase out policies? This paper seeks to build an interdisciplinary account fusing insights from diverse theoretical traditions from international political economy, political science, sociology and the literature on socio-technical transitions in order to capture the interaction of political, economic and socio-cultural drivers in national and international settings which can provide the basis of a more integrated and multi-dimensional understanding of supply-side policies. Such an account, we suggest, helps to understand the origins and evolution of supply-side policies and, more critically, the conditions which might enable the expansion of supply-side climate policies to new sites.
Determinants of Net Transactions in TARGET2 of European Banks Based on Micro-data
Authors: Drott Constantin , Goldbach Stefan , Jochem Axel 
Published: February 2024

Abstract
This paper examines German and foreign bank factors that can explain net flows of cross-border central bank liquidity between Germany and the rest of the euro area. Using data from the German component of Eurosystem’s real-time gross settlement system TARGET2 and BankFocus for the period between 2009 and 2021, we provide empirical evidence that only few balance sheet items and profit and loss accounts affect net flows with Germany. We control for bilateral bank-specific relationships and time-varying macroeconomic country effects in our regressions. In general, German bank factors seem to be more important than characteristics of foreign banks. A German bank that exhibits relatively high claims against central banks seems to attract less additional central bank liquidity from abroad than a German bank with fewer existing central bank claims. Net claims against central banks, which also control for liabilities, have no effect on net transactions in TARGET2. However, higher overall liquidity of a German credit institution corresponds to additional net inflows. Foreign bank factors only matter for central bank payments and intragroup payments. We also document heterogeneities across different types of transactions which influence the German TARGET2 balance. While customer payments, interbank payments and central bank payments have increased net flows to Germany in sum, intragroup payments and ancillary systems’ transactions have led to net outflows.
Case Report: An Adult Case of Poretti-Boltshauser Syndrome Diagnosed by Medical Checkup
Authors: Ikeda Kensuke , Tamagake Ayane , Kubota Takafumi , Izumi Rumiko , Yamaguchi Tatsuo , Yanagi Kumiko , Misu Tatsuro , Aoki Yoko , Kaname Tadashi , Aoki Masashi 
Published: February 2024

AbstractThis report describes an adult case of Poretti–Boltshauser syndrome (PTBHS) and with novel variants of LAMA1. A 65-year-old Japanese woman with cerebellar malformation identified during a medical checkup was referred to our hospital. Subsequently, neurological examination, brain imaging, and genetic investigation via whole-exome sequencing were performed. The patient presented with mild cerebellar ataxia and intellectual disability. Magnetic resonance imaging revealed cerebellar dysplasia and cysts and an absence of molar tooth sign. Genetic analysis revealed a novel homozygous variant of c.1711_1712del in LAMA1 (NM_005559.4). Most cases with PTBHS are reported in pediatric patients; however, our patient expressed a mild phenotype and was undiagnosed until her 60 s. These findings suggest that PTBHS should be considered in not only pediatric cerebellar dysplasia but also adult cerebellar ataxia with mild presentation.
The first cetacean from the early Oligocene of the SW German Mainz Basin: a probable cheek tooth of a mysticete (Mammalia: Cetacea)
Authors: Hampe Oliver , von der Hocht Fritz 
Published: February 2024

AbstractDespite two centuries of fossils collecting, no cetacean remains from the Oligocene marine deposits of the Mainz Basin (western Germany) have ever been reported. Here, we describe a possible mysticete tooth from the sand pit of Eckelsheim, which exposes high energy deposits belonging to the Rupelian Alzey Formation. The latter has yielded a rich assemblage of vertebrates and invertebrates, but so far, only one marine mammal in the form of the sirenian Kaupitherium. The whale tooth in some ways resembles the m2 of Llanocetus from the latest Eocene of Seymour Island, Antarctica. If the find from the Mainz Basin is not a regionally evolved form, Llanocetus, which is known from the South Atlantic, could have migrated through the Atlantic realm during the early Oligocene. It cannot be excluded that the tooth represents a more widely occurring lineage, neither endemic nor necessarily related to llanocetids, that—given the generally poor Rupelian record—has not been well documented yet.
Red Blood Cells in the Cerebrospinal Fluid Compartment After Subarachnoid Haemorrhage: Significance and Emerging Therapeutic Strategies
Authors: Bandyopadhyay Soham , Schwendinger Nina , Jahromi Behnam Rezai , Lad Shivanand P. , Blackburn Spiros , Wolf Stefan , Bulters Diederik , Galea Ian , Hugelshofer Michael 
Published: February 2024

Abstract
Subarachnoid haemorrhage (SAH) is a subtype of stroke that predominantly impacts younger individuals. It is associated with high mortality rates and can cause long-term disabilities. This review examines the contribution of the initial blood load and the dynamics of clot clearance to the pathophysiology of SAH and the risk of adverse outcomes. These outcomes include hydrocephalus and delayed cerebral ischaemia (DCI), with a particular focus on the impact of blood located in the cisternal spaces, as opposed to ventricular blood, in the development of DCI. The literature described underscores the prognostic value of haematoma characteristics, such as volume, density, and anatomical location. The limitations of traditional radiographic grading systems are discussed, compared with the more accurate volumetric quantification techniques for predicting patient prognosis. Further, the significance of red blood cells (RBCs) and their breakdown products in secondary brain injury after SAH is explored. The review presents novel interventions designed to accelerate clot clearance or mitigate the effects of toxic byproducts released from erythrolysis in the cerebrospinal fluid following SAH. In conclusion, this review offers deeper insights into the complex dynamics of SAH and discusses the potential pathways available for advancing its management.