bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nordihydroguaiaretic acid inhibits insulin‐like growth factor signaling, growth, and survival in human neuroblastoma cells
Authors: Meyer Gary E. , Chesler Louis , Liu Dandan , Gable Karissa , Maddux Betty A. , Goldenberg David D. , Youngren Jack F. , Goldfine Ira D. , Weiss William A. , Matthay Katherine K. , Rosenthal Stephen M. 
Published: May 2007

AbstractNeuroblastoma is a common pediatric malignancy that metastasizes to the liver, bone, and other organs. Children with metastatic disease have a less than 50% chance of survival with current treatments. Insulin‐like growth factors (IGFs) stimulate neuroblastoma growth, survival, and motility, and are expressed by neuroblastoma cells and the tissues they invade. Thus, therapies that disrupt the effects of IGFs on neuroblastoma tumorigenesis may slow disease progression. We show that NVP‐AEW541, a specific inhibitor of the IGF‐I receptor (IGF‐IR), potently inhibits neuroblastoma growth in vitro. Nordihydroguaiaretic acid (NDGA), a phenolic compound isolated from the creosote bush (Larrea divaricata), has anti‐tumor properties against a number of malignancies, has been shown to inhibit the phosphorylation and activation of the IGF‐IR in breast cancer cells, and is currently in Phase I trials for prostate cancer. In the present study in neuroblastoma, NDGA inhibits IGF‐I‐mediated activation of the IGF‐IR and disrupts activation of ERK and Akt signaling pathways induced by IGF‐I. NDGA inhibits growth of neuroblastoma cells and induces apoptosis at higher doses, causing IGF‐I‐resistant activation of caspase‐3 and a large increase in the fraction of sub‐G0 cells. In addition, NDGA inhibits the growth of xenografted human neuroblastoma tumors in nude mice. These results indicate that NDGA may be useful in the treatment of neuroblastoma and may function in part via disruption of IGF‐IR signaling. J. Cell. Biochem. 102: 1529–1541, 2007. © 2007 Wiley‐Liss, Inc.
Reduction of PKCα decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma
Authors: Wu Trang‐Tiau , Hsieh Yi‐Hsien , Hsieh Yih‐Shou , Liu Jer‐Yuh 
Published: May 2007

AbstractProtein kinase C (PKC) superfamily play key regulatory roles on the development of cancer. However, the exact role of these enzymes in human hepatocellular carcinoma (HCC) has not been well established. Using the RT‐PCR and Western blotting to analyze the levels of PKC isoforms mRNA and protein in the five different differentiated hepatoma cell lines, we found that PKCα was highly expressed in the poor‐differentiated HCC cell lines (SK‐Hep‐1 and HA22T/VGH) as compared with that in the well‐differentiated HCC cell lines (PLC/PRF/5, Hep3B, and HepG2). When treated with PKCα antisense oligonucleotides (ODN), both HA22T/VGH and SK‐Hep‐1 cells lines showed the reduction of PKCα expression, as well as a deceleration in the growth rate and in the level of cyclin D1, but the increase in the levels of p53 and p21WAF1/CIP1. Moreover, the reduction of PKCα expression also inhibited the migratory and invasive potential of both HA22T/VGH and SK‐Hep‐1 cells lines, and revealed a down‐regulation of several migration/invasion‐related genes (MMP‐1, u‐PA, u‐PAR, and FAK). These phenomenon were also confirmed by DNA‐based small interfering RNA (siRNA) PKCα and PKCα/β specific inhibitor Go6976. Thus, the results indicated that PKCα may be associated with regulation of cell proliferation/migration/invasion in human poorly differentiated HCC cells, suggesting a role for the PKCα in the malignant progression of human HCC. J. Cell. Biochem. 103: 9–20, 2008. © 2007 Wiley‐Liss, Inc.
Spontaneous rupture with pseudoaneurysm formation in a nodular goiter presenting as a large neck mass
Authors: Chang Chia‐Che , Chou Yi‐Hong , Tiu Chui‐Mei , Chiou Hong‐Jen , Wang Hsin‐Kai , Chiou See‐Ying , Chen Siew‐Peng , Chang Ming‐Wei , Chang Chi‐Houng , Hong Ting‐Han 
Published: May 2007

AbstractAcute airway obstruction caused by goiter hemorrhage is a rare but potentially life‐threatening condition. We report a case of nodular goiter in which spontaneous rupture with active bleeding developed suddenly, presenting as a large neck mass with dyspnea. Sonographic examination revealed a large inhomogeneous soft tissue mass in the left thyroid lobe containing some hypoechoic areas. Color Doppler and spectral Doppler analysis were consistent with a large hematoma and pseudoaneurysm, which was subsequently confirmed at surgery. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2007
Thromboembolic complications of left ventricular noncompaction: Case report and brief review of the literature
Authors: Pitta Sridevi , Thatai Deepak , Afonso Luis 
Published: May 2007

AbstractLeft ventricular noncompaction (LVNC) is a rare condition that is believed to represent an arrest in endomyocardial morphogenesis. This entity may be complicated by the development of mural thrombi and embolic events, however data on the associated thromboembolic risk is variable and poorly defined. We describe 2 cases of LVNC in African American patients presenting with thromboembolic manifestations and briefly review the available literature relevant to this complication. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2007
Value of ultrasound‐guided core biopsy in the diagnosis of malignant lymphoma
Authors: de Larrinoa Aitor Fernández , del Cura Jose , Zabala Rosa , Fuertes Elena , Bilbao Francisco , Lopez Jose I. 
Published: May 2007

AbstractPurpose.Ultrasound‐guided core needle biopsy for the diagnosis and management of malignant lymphomas is controversial and has not been accepted as an alternative to surgical biopsy. We investigate the clinical usefulness of this procedure in a large series of patients.Methods.Over a 5‐year period (2000–2004), ultrasound‐guided core needle biopsies were performed in 102 malignant lymphomas. Five diagnostic categories were considered: large B‐cell lymphomas (LBCL), small B‐cell lymphomas (SBCL), Hodgkin's disease (HD), T cell lymphomas, and miscellaneous. Surgical excisional biopsy of the node was performed in 47 cases (46.1%) for diagnostic confirmation.Results.The overall diagnostic accuracy of ultrasound‐guided core needle biopsy was 88.2% (90/102). SBCL (39), LBCL (36), HD (15), T cell lymphomas (5), and miscellaneous (7) [including T cell–rich B cell (2), natural killer cell (1), Burkitt's lymphoma (1), and non‐Hodgkin's lymphoma of the B cell type, NOS (3)] were correctly diagnosed. Three HDs, 1 natural killer cell lymphoma, 1 follicular lymphoma, and 1 LBCL were not correctly diagnosed. The core needle biopsy did not yield tumor tissue in 6 cases.Conclusions.Ultrasound‐guided core needle biopsy is effective in the diagnosis of malignant lymphomas and can be used as the first diagnostic approach in selected clinical situations. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2007
Three‐dimensional clavicular and acromioclavicular rotations during arm abduction using vertically open MRI
Authors: Sahara Wataru , Sugamoto Kazuomi , Murai Masakazu , Yoshikawa Hideki 
Published: May 2007

AbstractThere have been several reports about the clavicular and acromioclavicular motion, but a precise motion has been unknown. The purpose of this study was to analyze the 3D kinematics of the clavicle and acromioclavicular joint during arm abduction, using 3D MR images obtained by a vertically open MRI. Seven subjects participated in this investigation, which included 14 shoulders. From a seated position, we obtained MR images of their shoulder in seven abducted positions of the arm in the coronal plane. We evaluated the 3D movements of each bone in the shoulder using the volume‐based registration technique, and analyzed the clavicular positions relative to the lung and the scapular positions relative to the clavicle. During arm abduction, the clavicular motion relative to the lung showed 30.6° retraction, 7.3° elevation, and 33.2° posterior axial rotation. During arm abduction, the scapular motion relative to the clavicle showed 15.6° protraction, 21.5° upward rotation, and 22.2° posterior tilting. This study succeeded in describing the 3D clavicular and acromioclavicular motion including the axial rotation of the clavicle, and it revealed that both motions had large degrees of rotations. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1243–1249, 2007
The Rb family connects with the Tp53 family in skin carcinogenesis
Authors: Lara María Fernanda , Paramio Jesús M. 
Published: May 2007

AbstractIn contrast with the low frequency of alterations found in the Rb gene, the pRb pathway is inactivated in the vast majority of human tumors. A similar situation takes place in mouse models of cancer, including two‐stage skin tumorigenesis. This might be explained if the Rb functions are carried out, in its absence, by other proteins that are also controlled by the same upstream regulators and display similar effectors. The other Rb family members, p107 and or p130, are plausible candidates. The embryonic lethality of pRb‐deficient animals, which precludes the analysis of the roles of Rb gene in mouse models, has been avoided using tissue‐specific deletion of pRb. In epidermis, pRb deletion leads to altered proliferation and differentiation. However, these deficient mice do not develop spontaneous tumors, and chemical carcinogenesis experiments revealed that the absence of pRb renders fewer and smaller tumors than control animals, but showing increased malignant conversion to squamous cell carcinomas (SCC). Detailed biochemical analyses have indicated that, in the absence of pRb, multiple pathways, including the aberrant p53 activation mediated by E2F/p19ARF, are activated leading to increased tumor apoptosis. As Rb loss in epidermis is functionally compensated by Rbl1 (p107), this might also suggest that p107 could behave as a tumor suppressor. We summarize here our findings in support of this hypothesis. The pRb−;p107−/− epidermis form spontaneous tumors, and the reduction of p107 levels restores the susceptibility of pRb‐mice to chemical skin carcinogenesis experiments. Moreover, Rb‐deficient keratinocytes are highly susceptible to Ha‐ras‐induced transformation, and this susceptibility is enhanced by p107 loss. Further functional studies have indicated that the loss of p107 in the absence of pRb produces the reduction of p53‐dependent proapoptotic signals through the modulation of p63 and p73 isoforms. In addition, expression profiling analysis has revealed multiple oncogenic alterations that can contribute to tumor susceptibility in epidermis in the absence of pRb and p107. © 2007 Wiley‐Liss, Inc.
Is there seasonal variation in risk of Parkinson's disease?
Authors: Postuma Ronald B. , Wolfson Christina , Rajput Ali , Stoessl A. Jon , Martin W.R. Wayne , Suchowersky Oksana , Chouinard Sylvain , Panisset Michel , Jog Mandar S. , Grimes David A. , Marras Connie , Lang Anthony E. 
Published: May 2007

AbstractRecent studies suggest that, for many adult‐onset neurological diseases, persons born at a certain time of year are at higher risk of the disease. Small‐scale studies have suggested that persons born in the spring may be at higher risk of developing Parkinson's disease (PD) late in life. There have also been suggestions that there are clusters of PD birth dates in the years of major influenza pandemics. To determine whether there is any seasonal variation in the birth dates of PD patients, we examined birth dates of 8,168 PD patients collected from subspecialty movement disorder clinics across Canada. Patterns of seasonality of birth were examined and compared with the general Canadian population. In addition, we compared counts of patients born in the years of major influenza pandemics with the number born in the surrounding years. We found no evidence of systematic seasonal variation in PD incidence by birth date, or of clustering of birth dates during influenza pandemic years in PD patients. © 2006 Movement Disorder Society
Role of DAT‐SPECT in the diagnostic work up of Parkinsonism
Authors: Scherfler Christoph , Schwarz Johannes , Antonini Angelo , Grosset Donald , Valldeoriola Francesc , Marek Kenneth , Oertel Wolfgang , Tolosa Eduardo , Lees Andrew J. , Poewe Werner 
Published: May 2007

AbstractThe diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT‐SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug‐induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT‐SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression. © 2007 Movement Disorder Society
Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis
Authors: Chakravarty S. , Kadunganattil S. , Bansal P. , Sharma R.K. , Gupta S.K. 
Published: May 2007

AbstractTo delineate the functional aspects of zona pellucida (ZP) glycoproteins during fertilization in human, in the present study, fluorochrome‐conjugated Escherichia coli (E. coli)‐ and baculovirus‐expressed recombinant human ZP glycoprotein‐2 (ZP2), ‐3 (ZP3), and ‐4 (ZP4) were employed. In an immunofluorescence assay, capacitated human sperm exhibited binding of the baculovirus‐expressed recombinant ZP3 as well as ZP4 to either acrosomal cap or equatorial region whereas acrosome‐reacted sperm failed to show any binding to the acrosomal cap. Using double labeling experiments, simultaneous binding of ZP3 and ZP4 to the acrosomal cap was observed suggesting the possibility of different binding sites of these proteins on the sperm surface. No binding of ZP2 was observed to the capacitated sperm. However, acrosome‐reacted sperm (20.00 ± 1.93%) showed binding of ZP2 that was restricted to only equatorial region. Interestingly, E. coli‐expressed recombinant human zona proteins also showed very similar binding profiles. Competitive inhibition studies with unlabeled recombinant human zona proteins revealed the specificity of the above binding characteristics. Binding characteristics have been further validated by an indirect immunofluorescence assay using native human heat solubilized isolated zona pellucida. Employing baculovirus‐expressed recombinant ZP3 and ZP4 with reduced N‐linked glycosylation and respective E. coli‐expressed recombinant proteins, it was observed that glycosylation is required for induction of acrosomal exocytosis but its absence may not compromise on their binding ability. These studies have revealed the binding profile of individual human zona protein to spermatozoa and further strengthened the importance of glycosylation of zona proteins for acrosomal exocytosis in spermatozoa. Mol. Reprod. Dev. 75: 75–88, 2008. © 2007 Wiley‐Liss, Inc.
Effects of gonadotrophins, growth hormone, and activin A on enzymatically isolated follicle growth, oocyte chromatin organization, and steroid secretion
Authors: Ola Safiriyu Idowu , Ai Jun‐Shu , Liu Jing‐He , Wang Qiang , Wang Zhen‐Bo , Chen Da‐Yuan , Sun Qing‐Yuan 
Published: May 2007

AbstractSo far, standard follicle culture systems can produce blastocyst from less than 40% of the in vitro matured oocytes compared to over 70% in the in vivo counterpart. Because the capacity for embryonic development is strictly associated with the terminal stage of oocyte growth, the nuclear maturity status of the in vitro grown oocyte was the subject of this study. Mouse early preantral follicles (100–130 µm) and early antral follicles (170–200 µm) isolated enzymatically were cultured for 12 and 4 days, respectively, in a collagen‐free dish. The serum‐based media were supplemented with either 100 mIU/ml FSH (FSH only); 100 mIU/ml FSH + 10 mIU/ml LH (FSH‐LH); 100 mIU/ml FSH + 1 mIU/ml GH (FSH‐GH) or 100 mIU/ml FSH + 100 ng/ml activin A (FSH‐AA). Follicle survival was highest in follicle stimulating hormone (FSH)‐AA group in both cultured preantral (91.8%) and antral follicles (82.7%). Survival rates in the other groups ranged between 48% (FSH only, preantral follicle culture) and 78.7% (FSH only, antral follicle culture). Estradiol and progesterone were undetectable in medium lacking gonadotrophins while AA supplementation in synergy with FSH caused increased estradiol secretion and a simultaneously lowered progesterone secretion. Chromatin configuration of oocytes from surviving follicles at the end of culture revealed that there were twice more developmentally incompetent non‐surrounded nucleolus (NSN) oocytes (>65%) than the competent surrounded nucleolus (SN) oocytes (<34%). We conclude that the present standard follicle culture system does not produce optimum proportion of developmentally competent oocytes. Mol. Reprod. Dev. 75: 89–96, 2008. © 2007 Wiley‐Liss, Inc.
Cerebral involvement in myotonic dystrophies
Authors: Meola Giovanni , Sansone Valeria 
Published: May 2007

AbstractMyotonic dystrophy types 1 (DM1) and 2 (DM2) are similar yet distinct autosomal‐dominant disorders characterized by muscle weakness, myotonia, cataracts, and multiple organ involvement, including the brain. One key difference between DM1 and DM2 is that a congenital form has been described for DM1 only. Expression of RNA transcripts containing pathogenic repeat lengths produces defects in alternative splicing of multiple RNAs, sequesters specific repeat‐binding proteins, and ultimately leads to developmentally inappropriate splice products for a particular tissue. Whether brain pathology in its entirety in adult DM1 and DM2 is caused by interference in RNA processing remains to be determined. This review focuses on the similarities and differences between DM1 and DM2 with respect to neuropsychological, neuropathological, and neuroimaging data relating to cerebral involvement, with special emphasis on the clinical relevance and social consequences of such involvement. Muscle Nerve, 2007
Velocity recovery function of the compound muscle action potential assessed with doublet and triplet stimulation
Authors: Kamavuako Ernest Nlandu , Hennings Kristian , Farina Dario 
Published: May 2007

AbstractNormative values of muscle fiber conduction velocity depend on the conditions in which conduction velocity is measured due to the velocity recovery function (VRF) of muscle fibers. In this study the VRF of the compound muscle action potential (CMAP) was assessed following doublet and triplet stimulation in order to investigate the effect of repetitive muscle activation on muscle fiber conduction velocity. The VRF from doublet and triplet activation showed a peak of 4.6%–15.0% and 6.4%–25.9%, respectively, which is not significantly different. The VRF of the CMAP with doublet stimulation had a plateau between 25–75 ms, similar to that reported for single muscle fibers, and changed as a consequence of previous activation. The VRFs with doublet and triplet stimulation were different for interstimulus intervals in the range of 12–250 ms, where the triplet resulted in a plateau of supernormal conduction velocity. The VRF of the triplet could be explained by linear summation of the effects from doublet stimulations only for small distances between the two conditioning stimuli. These results provide new information on the adaptation of membrane properties of muscle fibers to repetitive activation. Changes in CMAP properties due to repeated activation may influence the accuracy of techniques based on CMAP recordings, such as collision methods. Muscle Nerve, 2007
Impact of gravity loading on post‐stroke reaching and its relationship to weakness
Authors: Beer Randall F. , Ellis Michael D. , Holubar Bradley G. , Dewald Julius P.A. 
Published: May 2007

AbstractThe ability to extend the elbow following stroke depends on the magnitude and direction of torques acting at the shoulder. The mechanisms underlying this link remain unclear. The purpose of this study was to evaluate whether the effects of shoulder loading on elbow function were related to weakness or its distribution in the paretic limb. Ten subjects with longstanding hemiparesis performed movements with the arm either passively supported against gravity by an air bearing, or by activation of shoulder muscles. Isometric maximum voluntary torques at the elbow and shoulder were measured using a load cell. The speed and range of elbow extension movements were negatively impacted by actively supporting the paretic limb against gravity. However, the effects of gravity loading were not related to proximal weakness or abnormalities in the elbow flexor–extensor strength balance. The findings support the existence of abnormal descending motor commands that constrain the ability of stroke survivors to generate elbow extension torque in combination with abduction torque at the shoulder. Muscle Nerve, 2007
The impact of component commonality on composite assembly policies
Authors: Eynan Amit , Rosenblatt Meir J. 
Published: May 2007

AbstractAssemble in Advance (AIA) policy reduces assembly cost due to advance planning, while Assemble to Order (ATO) policy eliminates assembly of excessive (more than demanded) units. The tradeoffs between the two policies have been studied in the past for single product environments. Moreover, it was shown that it is beneficial to employ AIA and ATO simultaneously. In this article, we study the employment of such a composite assembly policy in a multiproduct environment with component commonality. When common components are used, ATO may also enable us to benefit from the risk pooling effect. We provide important managerial insights such as: the multiperiod problem is myopic and changes in inventory levels due to the use of common components, and demonstrate the potential profit increase compared to other policies.© 2007 Wiley Periodicals, Inc. Naval Research Logistics, 2007
The problem of aiming and ewasion
Authors: Isaaca Rufus 
Published: May 2007

AbstractThe general problem of a marksman versus a mobile target, with a time lag in the gunner's information as to the target's position, appears in many guises in many situations. It is a classic military problem. Formulated in terms of game theory, the desiderata are: How should the target best maneuver to confound prediction of his positions How and when should the marksman make this prediction? What hit probability is to be expected when both participants behave optimally?This paper discusses this general class of problems and then settles on one which seems to be the simplest possible example that is not trivial. Nevertheless it is difficult. In two previous papers devoted to it, the evader's best strategy and value of the game were given. Here the emphasis is on the marksman. He has no optimal strategy, but does have an ideal strategy with the property that every near optimal strategy is close to it. He also has a class of passive ε‐strategies such that if and only if he obeys their dictates will he either come within ε of the best hit probability or else always remain in a position where it is possible to do so.