bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Dipyridamole Thallium 201 Scintigraphy and Clinical Examination in the Determination of Cardiac Risk Before Arterial Reconstruction
Authors: Vasehus Madsen Poul , Vissing Michael , Munck Ole , Kelbaek Henning 
Published: November 2007

Preoperative clinical examination, including a 12-lead resting ECG, and pla nar dipyridamole thallium imaging (DTI) were compared in a prospective study of 65 vascular surgical patients in regard to their value for predicting postopera tive cardiac complications. Fifty-three patients underwent abdominal vascular procedures and 12 were operated on for peripheral artery disease. Thirty-six patients had ischemic heart disease (IHD) and/or abnormal find ings from 12-lead resting ECG. Of these 36 patients, 11 had nonfatal cardiac complications. The remaining 29 patients were free of IHD and had normal results from ECG. No complications occurred among these 29 patients. There was no postoperative death. Thallium imaging results were abnormal in 45 patients, showing either redis tribution and/or scar tissue or low washout. In 18 of these patients major changes with redistribution were present in all projections. Among these patients, 9 had a nonfatal cardiac complication. In the 27 patients with abnormalities in only one or two projections, only 2 had a cardiac event postoperatively. No cardiac complications occurred in patients with normal thallium scintigraphy findings. The patients were operated on irrespective of the results of the scans, and all recovered from any cardiac complications that occurred. In vascular surgical patients with previous IHD and/or abnormal findings from resting ECGs further risk stratification is achieved with DTI.
The Effect of Enalapril Maleate on Cerebral Blood Flow in Chronic Cerebral Infarction
Authors: Kobayashi Shotai , Yamaguchi Shuhei , Okada Kazunori , Suyama Nobuo , Bokura Kazunori , Murao Mituyoshi 
Published: November 2007

The influence of long-term oral administration of enalapril maleate (an an giotensin II-converting enzyme inhibitor) on regional cerebral blood flow (rCBF) was studied in 10 patients with chronic cerebral infarction. The rCBF was meas ured by a 133Xe inhalation method before and after a mean of sixty-five days' administration of 5 mg of enalapril. Results: Mean arterial blood pressure (MABP) was mildly decreased in 6 pa tients, but the average change in MABP was not significant (Endtidal partial pressure of carbon dioxide (PeCO2) was not changed significantly. The mean rCBF was increased by 8% after administration of enalapril (0.05 < p<0.1) There was no significant correlation between percent change in MABP and the percent change in rCBF. These results indicate that enalapril has not only antihyperten sive action but also a beneficial effect on the cerebral circulation in patients with chronic cerebral infarction.
Favorable Clinical Effects of Iloprost Infusion in 4 Uremic Patients with Critical Limb Ischemia
Authors: Bedani Pier Luigi , Perini Leonella , Farinelli Roberto , Fabbian Fabio , Fiocchi Orazio , Guerra Severino , Vanini Antonietta , Gilli Paolo 
Published: November 2007

Four uremic patients with advanced peripheral arterial occlusive disease (PAOD) of lower limbs causing rest pain and ischemic-necrotic lesions were treated with a four-hour intravenous infusion of Iloprost at doses of 0.75-2.5 ng/kg/min for twenty-eight days. After a week of the therapy all patients experi enced disappearance of rest pain and prolonged walking distance. At the end of the trial a diabetic patient showed a complete regression of the necrotic areas of two toes while the other patients still showed ischemic-necrotic foot lesions that were well demarcated. Iloprost therapy can be effective in uremic patients with severe PAOD.
Hemodynamic Characteristics of Patients with Coronary Artery Disease Presenting False-Negative Exercise Stress Test
Authors: Sekiya Michihito , Suzuki Makoto , Fujiwara Yasushi , Sumimoto Takumi , Hamada Mareomi , Hiwada Kunio 
Published: November 2007

The present study was designed to clarify the characteristics of left ventricu lar hemodynamics and coronary arteries in patients with coronary artery dis ease presenting false-negative response to the Master's two-step stress test. Eighty-eight consecutive patients performed the Master's two-step stress test and had coronary angiography for evaluation of suspected or known coronary artery disease. The frequency of false-negative and true-positive responses in the Master's two-step stress test was 20% and 45%, respectively. Elevated left ventricular end-diastolic pressure, reduced ejection fraction, and low cardiac output characterized the left ventricular hemodynamics in patients with false- negative responses, as compared with those with true-positive response. The severity and extent of coronary artery disease, as well as prior myocardial in farction, did not affect the frequency of false-negative response. This study indicates that the false-negative response to the Master's two-step test is unexpectedly frequent in coronary artery disease with severe left ventric ular dysfunction. Thus, one should be careful in judging the results of the Mas ter's two-step test in symptomatic patients with severe left ventricular dysfunction.
Effect of Pentoxifylline on Treatment of Lower Limb Ulcers in Patients with Thalassemia Major
Authors: Angelides N.S. , Angastiniotis Ch. , Pavlides N. 
Published: November 2007

The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major. The results indicated that the regular use of deferoxamine at an intravenous dose of 20 mg/kg did not affect the healing progress and the recurrence rate of these ulcers significantly. On the contrary, the oral administration of pentoxifyl line at a dose of 1,200 mg daily during the ulcer's healing time and at a low long- term maintenance dose of 400 mg daily during the ulcer-free intervals improved their healing ability impressively and diminished their recurrence rate signifi cantly.
Ventricular Arrhythmias Induced by Programmed Ventricular Stimulation After Uncomplicated Myocardial Infarction
Authors: Hueb Whady , Bellotti Giovanni , Sosa Eduardo , Ramires José Antonio , da Luz Protasio Lemos , Pileggi Fulvio 
Published: November 2007

The aim of this study was to correlate the occurrence of ventricular dys rhythmias induced by programmed ventricular stimulation and sudden cardiac death (SCD) after a first episode of acute myocardial infarction (AMI). Twenty-seven consecutive male patients aged fifty-four ± six (forty-seven to seventy) years were studied prospectively. Thirty days after AMI, patients were submitted to coronary arteriography and programmed ventricular stimulation with the S2-S3-S4 protocol. Noninvasive assessments, including Holter monitor ing, ECG stress test, and radionuclide ejection fraction, were also repeated six and twelve months after AMI. Ventricular dysrhythmias were induced in all patients. According to such response, patients were divided into three groups: (1) repetitive ventricular re sponse (n = 9); (2) nonsustained ventricular tachycardia (n=8); and (3) sus tained ventricular tachycardia (n=10). All patients consistently developed complex ventricular dysrhythmias at Holter monitoring and ECG stress test. One patient from group 2 suffered SCD and another presented a syncope. Simi larly, in group 3, 2 patients suffered SCD, 1 during a documented episode of recurrent AMI. Except for 1 patient, radionuclide ejection fraction remained unchanged throughout the study in all cases. SCD was also unrelated to the presence and type of dysrhythmias at noninvasive evaluation. Therefore, the type of ventricular dysrhythmia induced by the S2-S3-S4 pro tocol has no correlation with late SCD in patients with a first AMI and pre served ejection fraction.
Heterogeneity of Rabbit Aortic Endothelial Cells, with Special Reference to Phagocytosis
Authors: Emura Sei , Masuko Sadahiko , Sunaga Toshiaki 
Published: November 2007

Heterogeneity of aortic endothelial cells with regard to phagocytotic ability was examined by injecting India ink into normal rabbits. Light and electron microscopic analyses revealed that particles of India ink were phagocytosed in the endothelial cells, which in turn were localized at the distal side of the orifice of aortic branches, especially those of brachiocephalic, left calvicular, and dor sal intercostal arteries. No remarkable differences were found ultrastructurally between phagocytosing and nonphagocytosing endothelial cells. Ingested India ink particles were present within phagosomes of the endothelial cells for several hours after injection; the particles eventually accumulated in the subendothelial space twenty-four hours after injection. These results indicate that an active transport system of large molecules via the phagocytotic processes is present in endothelial cells located at the distal sides of the orifice of aortic branches. These regions are known to develop initial atherosclerotic lesions in hypercholesterolemic animals. Thus, a possible corre lation between phagocytotic ability of endothelial cells and development of atherosclerosis is suggested.
Notes On Fifty Years of Pediatric Practice
Authors: Bass Murray H. 
Published: November 2007

"What distinguished Murray Bass from many of his contemporaries in the past as well as in the present was the harmonious allotment of his professional interests and en dowments. At ward rounds and in the dis pensary he was stimulating, at times brilliant but always an instructive, inspiring teacher. His gift of keen observation made him an un- equaled diagnostician; his broad clinical ex perience a wise therapist. "If one surveys the many scientific contri butions of Murray Bass covering a period of fifty years one is impressed by the wide range of his interests. Orthostatic albuminuria at tracted his attention in his first publications, probably as a result of his contact in Vienna with Jehle of the Childrens' Clinic. But sub sequently one can see how his scientific curi osity was stimulated by the problems arising from his own clinical experience. Observa tions of serious acute illness attracted his at tention to the dangerous idiosyncrasies of young children to metals and it was because of his penetrating analyses of cases of lead poisoning in nursing infants that the sale of nipple protectors containing this metal was prohibited in the State of New York. The clinical aspects of the Rh factor published jointly with Dr. Peter Vogel, vitamin A de ficiency in infants, periorbital edema as the initial sign of infectious mononucleosis, are relevant examples from the later period of his scientific activity. "Murray Bass was a great physician, one of the greatest I have ever met. His was a God given gift of a rare personality which com bined qualities not often found together ; love, dedication to duty and intellectual curi osity. He utilized these qualities to the fullest and he was rewarded by the love and grati tude of thousands to whom he had been a comfort in times of anxiety with his compe tence and wisdom."—PAUL KLEMPERER, M.D., from J. Mt. Sinai Hosp. 21: 371, Sept.- Oct. 1962.
Congenital Pneumonia
Authors: Davies Pamela A. 
Published: November 2007

The finding of polymorphs in the lung alveoli of fresh stillbirths and very early neo natal deaths is traditionally known as congenital pneumonia, though clear histological signs of pulmonary inflammation are lacking in most cases. An analysis of their clinical features is presented which supports the view that such pneumonia is a passively acquired condition due to asphyxial aspiration of maternal inflammatory cells. True congenital pneumonia due to transplacental infection is rare, and is often but one manifestation of a generalized disease.
Outpatient Practice
Authors: Freedman Alan R. 
Published: November 2007

"You only see the rare problems in your pediatric residency training." "Residents are not being prepared for private pediatric practice." "They no longer teach you how to treat the common problems of children." What resident in pediatrics at a teach ing institution has not heard these and related comments from visiting staff mem bers and from practitioners whom they meet ? Are these charges true, or are they, like so many other assertions in medi cine, opinions rather than facts ?
Delayed and Irregular Maturation Versus Minimal Brain Injury
Authors: Abrams Alfred L. 
Published: November 2007

We are increasingly aware of the harm, both actual and potential, done to patient and parents from the designation of children with delayed and irregular maturation as "brain-damaged" or "suffering from brain dysfunction." The terror and anxiety wrought by such diagnoses, despite the fact that they are based on no current evidence of actual brain disease, is the topic of this paper.
Primary Macroglossia
Authors: Shafer Alan D. 
Published: November 2007

There is a clinical entity in which infants are born with large tongues as a consequence of idiopathic hypertrophy of the muscle fibers. Of nine such cases treated by this author, seven also had an omphalocele or an umbilical hernia—an association not well understood. An anterior wedge resection of the tongue at approximately six months of age to pro tect against prognathism and speech defects seems advisable.
Respiratory Disease in Children Caused by Parainfluenza Viruses
Authors: Ramkissoon Ramdath , McDowall Milton F. 
Published: November 2007

There was a sudden severe outbreak of acute respiratory disease in North Trinidad from October through December 1967. This affected all age groups, though particularly serious and widespread among children. in the first two years of life. Parainfluenza viruses were isolated from many of the patients who were sick enough to be hospitalized. The expressions of the infection, as here described, are on the whole distinctive.
An Analysis of Contemporary Prescribing Habits
Authors: Arnhold Rainer G. , Freedman Alan R. 
Published: November 2007

Physicians in practice try in many ways to keep up with the rapidly expanding body of pediatric knowledge. We read the current literature to learn what researchers all over the world are doing. We attend national conferences, meeting colleagues from all parts of the United States. We attend lectures and staff conferences at local teaching hospitals and medical societies, to confer with and to listen to other physicians to whom we at times may refer patients. Thus, we keep abreast in a general way of what may be termed the principles of prac tice in all parts of the world; but do we know anything at all about what's going on in the office down the street, the one around the corner or in any other office similar to ours in communities much like ours? How do our colleagues in practice handle certain prob lems ? Do they see the same kind of patients that we do? Are we prescribing too many antibiotics? Are we going overboard with drugs? Clinical Pediatrics, a journal specifically oriented toward men and women engaged in the private practice type care of children, shares this curiosity. Articles about private practice are frequently featured. The following solicited study is an example. R. G. Arnhold and Alan R. Freedman have individually contributed analytic articles in the past two years about their clinical observations.1 Inasmuch as prescription writ ing by doctors is a topic of perennial interest, Clinical Pediatrics asked these pediatricians at opposite ends of the country to survey and prepare a comparison of their prescription writing habits. This article presents a revealing synthesis of both sets of data.—Editor.
Blood Transfusion and Philately
Authors: Kyle Robert A. , Wolman Irving J. 
Published: November 2007

A three-page article on "Stamps Against Cancer" was published in the May 1964 is sue of CLINICAL PEDIATRICS and was reprinted widely. The reprints were used to help persuade the Post Office De partment to issue the anti-cancer com memorative, which appeared in 1965. Here is the start of another publicity campaign, directed this time toward pro motion of a blood-transfusion commem orative stamp for the United States.
Hemoglobin and Hematocrit Values of Adolescents
Authors: Daniel W.A. , Rowland Ann M. 
Published: November 2007

Using height-weight and hemoglobin-hematocrit values to estimate nutritional status, 268 consecutive adolescent patients from low-income families were evaluated at the adolescent clinic of the University of Alabama Medical Center. Only four of the 123 boys and six of the 145 had hemoglobin values less than 11 Gm./100 ml. of blood, and in only one patient was the anemia due solely to iron deficiency. White boys and girls had higher hemoglobin and. hematocrit values than Negro boys and girls. The mean hemoglobin values from this group of low-income adolescents were similar to those from surveys of Minnesota farm boys and girls and caf adolescents attending a high-income private school in New York City. A number of other observations of practical clinical value are discussed in the text.
Accidental Bed Deaths in Infants due to Unsafe Sleeping Situations
Authors: Smialek J.E. , Smialek P.Z. , Spitz W.U. 
Published: November 2007

Sixteen accidental deaths of infants occurred in Wayne County (Detroit) during 1974-1975 as a result of unsafe sleeping environments. Thirteen of these deaths resulted from different modes of asphyxia, two were due to falls, and one drowned. Differential diagnoses are pointed out. It is estimated that over 600 infants die each year in the United States due to unsafe sleeping conditions. Despite the magnitude and importance of this problem, little has been provided to the public in the form of preventive education. Federal regulations, passed in 1974, control the manufacture of new cribs but do not affect the existing unsafe cribs. Suggestions for the prevention of such fatal accidents are outlined, in cluding a safety check list for infant beds. The cooperation of all health professionals is required to educate the public of these dangers to their infants.
Enterovirus Infections in the Neonate
Authors: Krajden Sigmund , Middleton Peter J. 
Published: November 2007

A chart review was made of 24 neonates less than one month of age with culture-proven enteroviral infection. The seasonal distribution was summer and fall. An antecedent illness was common in the mother or other family members. One patient had a mild gastroenteritis. Three categories of severe disease were noted: (a) meningitis accounted for 50 per cent of the illnesses; (b) myocarditis for 25 per cent of the illnesses; and (c) the remainder presented with a severe sepsis-like illness. High mortality rate was associated with low birth weight and low gestational age.
A Protocol of Plain Radiographs, Hip Ultrasound, and Triple Phase Bone Scans in the Evaluation of the Painful Pediatric Hip
Authors: Alexander J.E. , Seibert J.J. , Aronson J. , Williamson S.L. , Glasier C.M. , Rodgers A.B. , Corbitt S.L. 
Published: November 2007

A useful protocol for the evaluation of hip pain in the pediatric patient, using a combination of plain radiographs, hip ultrasound (US), and triple phase radionuclide bone scans is presented. Patients with hip pain were initially evaluated by plain radiographs of the pelvis and hips. If no diagnosis was reached, the hips were studied for effusions by real-time hip ultrasonography. If an effusion was present, the joint was aspirated for diagnosis. If no effusion was present by US or if no diagnosis was reached by aspiration, triple phase radionuclide bone scans were performed. Fifty patients were evaluated by this prospective protocol, and the diagnosis was reached in 48 of the 50 cases (10 by plain radiographs, 16 by US, and aspiration of the joint, and 22 by triple phase bone scans). Hip effusions were found in 20 patients by US, with no false positives or false negatives. Previous studies for detecting effusions by US have emphasized absolute measurements of the capsular width, but we report a typical appearance of the hip capsule when fluid is present (a bulging convex capsule). When no effusion is present, the capsule is concave and parallels the long axis of the femoral neck.
High Levels of Lactate, Pyruvate, and Alanine in Anemic Children
Authors: Ceyhan Mehmet , Özalp Imran , Altay Çigdem 
Published: November 2007

Lactate, pyruvate, and alanine levels were investigated in patients with iron deficiency anemia and other types of anemia. The study was carried out on 36 children between 2 and 16 years of age. The study group was divided into three groups, each comprised of 12 children. It was shown that the anemic children have lower PO2, higher PCO2 and higher levels of lactate, pyruvate, and alanine than the control group (p < 0.05). There was a negative linear correlation between lactate levels and hemoglobin values (r = -0.6213; p < 0.05), but no correlation between hemoglobin and the alanine and pyruvate levels. Levels of lactate, pyruvate and alanine were similar in the iron deficiency and the other anemia groups. In conclusion, iron has no direct effect on the levels of lactate, pyruvate, and alanine, but the hypoxemia caused by anemia could be responsible for the higher levels of the lactate, pyruvate, and alanine. In cases with high levels of lactate, pyruvate, and alanine, anemia has to be considered in the differential diagnosis of hyperlactatemia.
Neonatal Gastric Volvulus Secondary to Rectal Atresia
Authors: Mizrahi Solly , Vinograd Itzhak , Schiller Medad 
Published: November 2007

The "upside-down stomach" is a rare form of organo-axial neonatal volvulus, which occurs because of absent or attenuated anatomical anchors and abnormal motility of the stomach. It is considered a surgical emergency that requires immediate correction. We report a previously undescribed etiology of gastric neonatal volvulus caused by an extremely distended transverse colon, secondary to rectal atresia. The etiologic and diagnostic considerations are discussed. Gastropexy in the form of gastrostomy proved to be an effective treatment.
Acute Gastroenteritis: Clinical Features According to Etiologic Agents
Authors: Khuffash Faisal A. , Sethi Sarvan K. , Shaltout Azza A. 
Published: November 2007

The clinical manifestations in 595 children hospitalized with gastroenteritis during a 15-month time frame were studied. They were divided into eight groups according to etiologic agent: rotavirus (203 patients); Salmonellae (98); Escherichia coli (55); Campylobacter (36); Shigella (22); combined rotavirus and salmonellae (44); combined rotavirus and other bacteria (26); and no pathogen (111). The mean duration of diarrhea was shortest in the rotavirus and "no pathogen" groups (4.8 and 5.6 days, respectively) and longest with pure and mixed salmonella infections (12.3 and 12.9 days, respectively). Associated manifestations were most frequent with salmonellae and least frequent with rotavirus and E. coli infections. Malnutrition also was most common with salmonellae and lowest with rotavirus and E. coli. There were no differences in the frequency of hypernatremia. Hyponatremia was most frequently encountered with salmonella (25% compared to 9% in the rest of the patients). Evidence of septicemia was found in 22 patients, 21 of whom were in the salmonella groups. The four deaths in this series (0.7%) also were in the salmonellae groups. The clinical severity of salmonella infection in developing countries, particularly in young and malnourished children, warrants attention to more intensive management. The selective use of antibiotics may help reduce the mortality and morbidity of gastroenteritis.