bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the healthcare decentralization provide better public health security capacity and health services satisfaction? An analysis of OECD countries
Authors: Durmuş Veli 
Published: March 2024

PurposeDecentralization has profound implications for many health systems. This study investigates the effect of health system decentralization in Organization for Economic Co-operation and Development (OECD) countries on public health security capacity and health service satisfaction.Design/methodology/approachMultiple linear regression analyses were employed for variables related to the level of health security capacity and satisfaction with the healthcare system while controlling for all socio-demographic variables from the European Social Survey, including over 44,000 respondents from 25 OECD countries. The Health Systems in Transition series of countries were used for assessing the decentralization level.FindingsThe result of multiple linear regression analyses showed that the level of decentralization in health systems was significantly associated with higher health security capacity (ß-coefficient 3.722, 95% confidence interval (CI) [3.536 3.908]; p=<0.001) and health service satisfaction (ß-coefficient 1.463, 95% CI [1.389 1.536]; p=<0.001) in the study. Countries with a higher level of decentralization in health policy tasks and areas were significantly likely to have higher health services satisfaction, whereas this satisfaction had a significant negative relation with the lower level of decentralization status of secondary/tertiary care services in OECD countries (ß-coefficient −5.250, 95% CI [−5.757–4.743]; p = 0.001).Originality/valueThis study contributes to a better understanding of the extent to which decentralization of health services affects public health safety capacity and satisfaction with health services, whereas the level of decentralization in OECD countries varies considerably. Overall, the findings highlight the importance of public health security and satisfaction with health care delivery in assessing the effects of decentralization in health services.
The effects of corporate social responsibility on innovation and performance of firms in China: a structural equation model analysis
Authors: Li Xiufeng , Zhang Zhen 
Published: March 2024

Purpose
This study aims to analyze and discuss the impact of corporate social responsibility (CSR) on firms’ performance, as well as to examine the interplay between CSR and the economy, society and innovation.

Design/methodology/approach
This paper collects data from 420 manufacturing firms across various geographical regions in China. By using a structural equation model, the paper investigates the impact of CSR on enterprise innovation, customer management capability, market competitiveness (MC) and firm financial performance.

Findings
The findings demonstrate that CSR performance positively contributes to enhancing the level of enterprise innovation, as well as customer management capability and market competitiveness. Furthermore, it assists enterprises in improving market competitiveness and elevating customer management capabilities. Thus, CSR can have a positive effect on the firm financial performance.

Originality/value
The outcomes presented in this paper offer valuable evidence regarding the influence of implementing CSR on different aspects of enterprise performance and innovation. Moreover, it provides practical recommendations for enterprises seeking to transition towards low-carbon practices and upgrade their manufacturing industry.
The dilemma of leadership development
Authors: Phillips Patti P. , Phillips Jack J. 
Published: March 2024

Purpose
In the field of leadership development, a dilemma exists with many executives, who often support and fund leadership development programs. Executives know that great leaders are needed to drive results, and for the most part, they must develop those leaders internally. At the same time, the leadership development providers are content with showing executives that they have changed leader behavior. The same providers are reluctant to connect behavior change to meaningful and important business measures. Yet, when used properly, leader behavior will drive all types of important impact measures in an organization. That is what executives want to see. This purpose of this article is to show how leadership development providers can connect their programs to important business measures and deliver value at the Impact and ROI Levels using the ROI Methodology.

Design/methodology/approach
Executives prefer to have leader behavior connected to impact, which is their No. 1 measure and return on investment (ROI), their No. 2 measure. Impact and ROI is the world they live in. Executives know that new leader behavior is necessary for impact and often have input into the behaviors they would like to see. When it comes to measuring success, they want to see how the program connects to the organization and the value the new behavior delivers. To avoid the possibility of disappointing results, implement the ROI Methodology framework to design the leadership development program to deliver the desired results and make sure that everyone involved is helping to deliver the needed success.

Findings
Leadership development providers must address the challenge of showing the value of leadership development. It is not that difficult to show the impact and ROI of major programs. Literally, hundreds of organizations are doing this now. The authors have published four books with different publishers on the value of leadership development, with case studies, and more will be published.

Originality/value
This level of evaluation can set the leadership development program apart from the others.
The interaction effect of goal orientation and mindfulness of entrepreneurs on firm innovation capability and its impact on firm performance
Authors: Ratanavanich Muanfhun , Charoensukmongkol Peerayuth 
Published: March 2024

Purpose
Grounded in the resource-based view of the firm, this study aims to examine the effects of goal orientation and the mindfulness of entrepreneurs on firm innovation capability and analyzes that capability’s subsequent impact on firm performance. The authors also analyze whether mindfulness interacts with goal orientation to intensify its effect on firm innovation capability.

Design/methodology/approach
Simple random sampling was used to obtain the sample of Thai firms listed in the Department of Business Development database (n = 304). The data analysis was done by using partial least square structural equation modeling.

Findings
Goal orientation and mindfulness are positively associated with firm innovation capability. The analysis also supports the interaction effect of goal orientation and mindfulness on firm innovation capability. Moreover, firm innovation capability is positively associated with firm performance.

Practical implications
Goal orientation and mindfulness should be considered two essential soft skills that entrepreneurs must develop to build up their firms’ innovation capability. Because entrepreneurs are the key drivers of economic growth and sustainable development, the government agencies responsible for the entrepreneurship development should consider goal orientation and mindfulness as parts of their entrepreneurship training program and development policy.

Originality/value
The finding about the interaction effect of goal orientation and mindfulness on firm innovation capability provides new evidence that was not documented in previous research. The authors clarify that these are entrepreneurial characteristics that could supplement each other to maximize the potential of entrepreneurs and strengthen the innovation capability of their firms.
Novel therapeutic targets in dermatomyositis
Authors: Bax Christina , Aghdasi Carmel , Fiorentino David 
Published: March 2024

AbstractDermatomyositis (DM) is a systemic autoimmune disease with variable clinical presentations, including inflammation in the skin, muscle, lungs, and/or joints. Current therapeutic strategies in DM typically include broad immunosuppression; however, the currently used modalities are not universally effective and are associated with various side effects, including risk of infection. There is currently a highly unmet need for more effective and well‐tolerated therapies. Recent years have witnessed increased interest in pharmaceutical development of new therapeutic strategies for DM. This review aims to summarize the landscape of therapies that are currently being tested or planned in patients with DM. These therapies have a wide variety of immunological targets, including T cells, B cells, inflammatory signaling pathways, type I interferons, autoantibodies, and other targets.
Soluble PD‐L1 predicts tumor response and immune‐related adverse events in patients with advanced melanoma treated with anti–PD‐1 antibodies
Authors: Oya Kazumasa , Nakamura Yoshiyuki , Shen Larina Tzu‐Wei , Ishizuki Shoichiro , Matsusaka Satoshi , Fujisawa Yasuhiro 
Published: March 2024

AbstractImmune checkpoint inhibitors (ICIs) bring prognostic benefits to patients with malignancies. However, there is a substantial number of patients whose lesions are not improved by ICIs. In addition, ICIs may cause immune‐related adverse events (irAEs), which could lead to an unfavorable prognosis with fatal consequences. Therefore, we conducted a retrospective study to evaluate the utility of circulating sPD‐L1 (soluble programmed cell death 1 ligand 1) as a biomarker in patients with advanced melanoma treated with anti–PD‐1 (programmed cell death 1 protein) antibodies. Sera from 31 consecutive patients were prospectively collected before and after anti–PD‐1 antibody treatment and the serum level of sPD‐L1 was evaluated. We found that high sPD‐L1 levels before treatment were associated with better prognosis, and this association was observed only in patients with a low tumor burden. We also found that sPD‐L1 levels were elevated in patients who developed severe irAEs after treatment, and the patients with severe irAEs had significantly higher fluctuations in sPD‐L1 (delta sPD‐L1) than those without severe irAEs. Our study suggests that serum sPD‐L1 level is a useful biomarker to predict tumor response and irAE development in patients with advanced melanoma treated with anti–PD‐1 antibodies.
Listening to experts is not always wise: Unravelling the dynamics of decision‐making in the crisis cell
Authors: De Vittoris Raphael G. , Lebrument Norbert , Bousquet Carole 
Published: March 2024

AbstractThe study challenges the conventional belief that expertise enhances crisis decision‐making. Analyzing crisis simulations, it reveals that crisis cells with minimal expertise achieved a commendable 69% decision quality, surpassing those with specialists. The research underscores the importance of collective intelligence and adherence to fundamental ‘metarules’ in decision‐making, irrespective of expertise. It questions the presumed benefits of expertise, suggesting that excessive reliance on experts may hinder information processing and flexibility during crises. The findings advocate for a reconsideration of the role of expertise in crisis management, emphasizing the significance of collective decision‐making and adherence to metarules. The study calls for further exploration of expert leaders' potential influence within crisis cells.
Expectation versus reality: How crisis statement essentials are evaluated by Gen Z stakeholders and crisis communication practitioners
Authors: Karinshak Elise , Voges Taylor , Jin Yan 
Published: March 2024

AbstractAt the onset of a crisis, an initial organizational statement sets the tone for subsequent discussion. While existing literature provides strategic guidance, it offers limited insight into the message‐level execution of such statements. This study synthesizes insights from literature and trade publications to complement strategic literature by proposing a practical set of ‘crisis essentials’ which practitioners can leverage in composing an initial crisis statement. Upon identification of these elements from scholarly and industry literature, two online surveys presenting a hypothetical crisis scenario are released to Gen Z stakeholders and crisis communication practitioners in the United States; respondents rate the relative importance of each element. Gen Z was selected as the stakeholder population of interest due to their high activity on social media, their role as the talent which will be entering the workforce and eventually leadership roles, and the more limited existing analysis of this segment. Comparative analysis is conducted, based on two online surveys among adult individuals from these two populations, to evaluate whether gaps exist in stakeholder expectations and practitioner approaches. Findings reveal: the proposed elements (e.g., statement of the crisis, attribution, expert quote; 11 in total) were of nonzero importance to both Gen Z stakeholder respondents and crisis communication practitioner respondents, essentials related to the assuring stakeholders (e.g., action steps) were rated more highly than informational essentials (e.g., timeline), and importance ratings across survey samples were generally consistent. Practitioners should consider each of these proposed essentials when developing communication materials, and that while stakeholders expect sufficient information to understand a crisis event, they ultimately care about what the crisis means for the future of the organization. This study, grounded in crisis communication theory, provides a relevant, practical contribution to the implementation of effective strategic crisis communication in situations concerning Gen Z stakeholders.
Eco‐friendly chitosan polymer mitigates disease severity and mediates plant resistance against Beet curly top Iran virus in tomato
Authors: Tokhmechi Kimia , Eini Omid , El Gamal Ahmed , Koolivand Davoud 
Published: March 2024

AbstractA tomato‐infecting virus known as Beet curly top Iran virus (BCTIV) cause a significant disease for tomato plants and several other plant species around the world. Chitosan polysaccharide is a natural biopolymer that has been utilised as an exo‐elicitor to enhance plant defence mechanisms against a variety of plant diseases. This study investigates the efficacy of chitosan in combating BCTIV disease on tomato plants and modulating the host–virus interaction under greenhouse conditions. Twenty‐four hours before the virus inoculation, tomato plants were sprayed with a protective chitosan solution at different concentrations (0.5, 1, 1.5, and 2 mg/mL). Tomato plants were inoculated with a BCTIV infectious clone using an Agrobacterium‐inoculation method. The findings clearly demonstrated a reduction in the severity of the disease in chitosan‐treated plants as compared to Mock‐plants, with the percentage decreasing from 61.53% to 75.28% in 1.5 mg/mL treated plants and from 9.01% to 28.43% in 0.5 mg/mL treated plants. In addition, the utilisation of chitosan has the potential to deactivate the accumulation of BCTIV within the host tissues. The virus accumulation was greatly alleviated in 1, 1.5, and 2 mg/mL‐treated plants by 71.29%, 90.11%, and 93.14%, respectively, and over the mock plants. Furthermore, it was found that chitosan applied at all tested concentrations increased the relative expression and mRNA accumulation of genes related to resistance, including the pathogenesis‐related protein gene PR‐1, the HSP90 gene, and the AGO2a antiviral gene. These genes reached their maximum by 22.9‐, 12.93‐, and 4.44‐fold increases, respectively, over the untreated control. According to gas chromatography–mass spectroscop (GC‐MS) fractionation profile, chitosan increased 28 bioactive metabolic components, such as n‐hexadecanoic acid, heptanone, 1,2‐dimethylbenzene, dicarboxylic acid, and cis‐11‐octadecenoic acid methyl‐ester, to improve metabolic pathways. Results reported here revealed that foliar application of chitosan decreases the rate of the disease severity and virus accumulation in BCTIV‐infected tomato plants. This effect is associated with increased gene expression and defence‐related factors, enhancing tomato resistance to BCTIV infection. Consequently, chitosan treatments could be part of an integrated approach for reducing the severity of BCTIV disease in tomato and other host plants.
Multi‐proteomic analyses of 5xFAD mice reveal new molecular signatures of early‐stage Alzheimer's disease
Authors: Lee Seulah , Jang Kuk‐In , Lee Hagyeong , Jo Yeon Suk , Kwon Dayoung , Park Geuna , Bae Sungwon , Kwon Yang Woo , Jang Jin‐Hyeok , Oh Yong‐Seok , Lee Chany , Yoon Jong Hyuk 
Published: March 2024

AbstractAn early diagnosis of Alzheimer's disease is crucial as treatment efficacy is limited to the early stages. However, the current diagnostic methods are limited to mid or later stages of disease development owing to the limitations of clinical examinations and amyloid plaque imaging. Therefore, this study aimed to identify molecular signatures including blood plasma extracellular vesicle biomarker proteins associated with Alzheimer's disease to aid early‐stage diagnosis. The hippocampus, cortex, and blood plasma extracellular vesicles of 3‐ and 6‐month‐old 5xFAD mice were analyzed using quantitative proteomics. Subsequent bioinformatics and biochemical analyses were performed to compare the molecular signatures between wild type and 5xFAD mice across different brain regions and age groups to elucidate disease pathology. There was a unique signature of significantly altered proteins in the hippocampal and cortical proteomes of 3‐ and 6‐month‐old mice. The plasma extracellular vesicle proteomes exhibited distinct informatic features compared with the other proteomes. Furthermore, the regulation of several canonical pathways (including phosphatidylinositol 3‐kinase/protein kinase B signaling) differed between the hippocampus and cortex. Twelve potential biomarkers for the detection of early‐stage Alzheimer's disease were identified and validated using plasma extracellular vesicles from stage‐divided patients. Finally, integrin α‐IIb, creatine kinase M‐type, filamin C, glutamine γ‐glutamyltransferase 2, and lysosomal α‐mannosidase were selected as distinguishing biomarkers for healthy individuals and early‐stage Alzheimer's disease patients using machine learning modeling with approximately 79% accuracy. Our study identified novel early‐stage molecular signatures associated with the progression of Alzheimer's disease, thereby providing novel insights into its pathogenesis.
Genomic characterization of dryland adaptation in endangered Anxi cattle in China
Authors: Lyu Yang , Yao Tingting , Chen Zhefu , Huangfu Ruiyao , Cheng Haijian , Ma Weidong , Qi Xingshan , Li Fuqiang , Chen Ningbo , Lei Chuzhao 
Published: March 2024

AbstractLocal species exhibit distinctive indigenous characteristics while showing unique productive and phenotypic traits. However, the advent of commercialization has posed a substantial threat to the survival of indigenous species. Anxi cattle, an endangered native breed in China, have evolved unique growth and reproductive characteristics in extreme desert and semidesert ecosystems. In this study, we conducted a genomic comparison of 10 Anxi cattle genomes with those of five other global populations/breeds to assess genetic diversity and identify candidate genomic regions in Anxi cattle. Population structure and genetic diversity analyses revealed that Anxi cattle are part of the East Asian cattle clade, exhibiting higher genetic diversity than commercial breeds. Through selective sweep analysis, we identified specific genetic variations linked to the environmental adaptability of Anxi cattle. Notably, we identified several candidate genes, including CERS3 involved in regulating skin permeability and antimicrobial functions, RBFOX2 associated with cardiac development, SLC16A7 participated in the regulation of pancreatic endocrine function, and SPATA3 related to reproduction. Our findings revealed the distinctive genomic features of Anxi cattle in dryland environments, provided invaluable insights for further research and breed preservation, and had important significance for enriching the domestic cattle breeding gene bank.
The neurological decline and psychological factors caused by coronavirus disease 2019 may be predictors of erectile dysfunction
Authors: Ma Yukuai , Zhu Tianle , Yang Peng , Gao Rui , Shen Lanhui , Gao Pan , Gao Jingjing , Liu Xi , Jiang Hui , Zhang Xiansheng 
Published: March 2024

AbstractBackgroundSince the outbreak of coronavirus disease 2019, it has had a serious impact on people's physical and mental health. However, in our clinical work, we have found that the erectile function of coronavirus disease 2019 patients with neurological decline was often seriously affected.ObjectivesTo further explore the relationship between erectile dysfunction and neurological dysfunction caused by coronavirus disease 2019.Materials and methodsWe conducted a survey from August 2022 to February 2023 at the First Affiliated Hospital of Anhui Medical University and the Third People's Hospital of Linyi City. A total of 251 subjects with a history of coronavirus disease 2019 infection were included. Symptoms and changes in erectile function after the coronavirus disease 2019 infection were collected and assessed using the International Index of Erectile Function‐5 scale and several targeted questions.ResultsIn this study, we found that in patients infected with novel coronavirus, the proportion of erectile dysfunction was higher in those with neurological manifestations such as olfactory and taste impairment or psychological symptoms such as anxiety.Discussion:We found that neurological decline and psychological factors were independent and significant risk factors for erectile dysfunction caused by coronavirus disease 2019.Conclusion:Patients with neurological damage or psychiatric symptoms are more likely to have erectile dysfunction, suggesting that the 2019 novel coronavirus may affect erectile function by damaging nerves. This provides a new insight into the mechanism of erectile dysfunction