bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of future insulin‐deficiency in glutamic acid decarboxylase autoantibody enzyme‐linked immunosorbent assay‐positive patients with slowly‐progressive type 1 diabetes
Authors: Kawasaki Eiji , Awata Takuya , Ikegami Hiroshi , Imagawa Akihisa , Oikawa Yoichi , Osawa Haruhiko , Katsuki Takeshi , Kanatsuna Norio , Kawamura Ryoichi , Kozawa Junji , Kodani Noriko , Kobayashi Tetsuro , Shimada Akira , Shimoda Masayuki , Takahashi Kazuma , Chujo Daisuke , Tsujimoto Tetsuro , Tsuchiya Kyoichiro , Terakawa Aiko , Terasaki Jungo , Nagasawa Kan , Noso Shinsuke , Fukui Tomoyasu , Horie Ichiro , Yasuda Kazuki , Yasuda Hisafumi , Yanai Hidekatsu , Hanafusa Toshiaki , Kajio Hiroshi ,   the Japanese Type 1 Diabetes Database Study (TIDE‐J)
Published: March 2024

AbstractAims/IntroductionThis study aimed to identify risk factors that contribute to the progression of slowly‐progressive type 1 diabetes by evaluating the positive predictive value (PPV) of factors associated with the progression to an insulin‐dependent state.Materials and MethodsWe selected 60 slowly‐progressive type 1 diabetes patients who tested positive for glutamic acid decarboxylase autoantibodies (GADA) at diagnosis from the Japanese Type 1 Diabetes Database Study. GADA levels in these patients were concurrently measured using both radioimmunoassay (RIA) and enzyme‐linked immunosorbent assay (ELISA) techniques.ResultsCompared with the non‐progressor group (fasting C‐peptide [F‐CPR] levels maintained ≥0.6 ng/mL), the progressor group showed a younger age at diagnosis, lower body mass index (BMI), lower F‐CPR levels and a higher prevalence of insulinoma‐associated antigen‐2 autoantibodies (IA‐2A). The PPV of RIA‐GADA increased from 56.3 to 70.0% in the high titer group (≥10 U/mL), and further increased to 76.9, 84.2, 81.0 and 75.0% when combined with specific thresholds for age at diagnosis <47 years, BMI <22.6 kg/m2, F‐CPR <1.41 ng/mL and IA‐2A positivity, respectively. In contrast, the PPV of ELISA‐GADA (71.8%) remained the same at 73.1% in the high titer group (≥180 U/mL), but increased to 81.8, 82.4 and 79.0% when evaluated in conjunction with age at diagnosis, BMI and F‐CPR level, respectively.ConclusionsOur findings show that, unlike RIA‐GADA, ELISA‐GADA shows no association between GADA titers and the risk of progression to an insulin‐dependent state. The PPV improves when age at diagnosis, BMI and F‐CPR levels are considered in combination.
Communicating clean technology: Green premium, competition, and ecolabels
Authors: Sengupta Aditi 
Published: March 2024

AbstractIn markets where differences in the environmental performance of competing firms arise due to differences in technology that cannot be altered in the short run and firms have private information about their own current technology, I show that market competition creates a strategic disincentive for adopting ecolabels (even if the cost of adoption is negligible) to directly and credibly communicate this private information to environmentally conscious consumers. Firms adopt ecolabels only if the green premium that buyers are willing to pay is large relative to the production cost advantage of dirty firms; ecolabels reduce market power, increase the market share of clean firms, and reduce expected environmental damage. I analyze firms' strategic (long‐run) incentive to invest in the development of clean technology where the outcome of such investment is uncertain. The availability of an ecolabel to directly communicate private information about the final outcome of such an investment enhances the expected net surplus whereas it reduces the ex ante strategic incentive to invest which in turn lowers industry investment in cleaner technology, relative to the case with no ecolabels.
Integrative taxonomy of metazoan parasites of the bluntnose sixgill sharkHexanchus griseus(Bonnaterre, 1788) in the Mediterranean Sea, with the resurrection ofGrillotia acanthoscolexRees, 1944 (Cestoda: Trypanorhyncha)
Authors: Lopez‐Verdejo Alejandro , Palomba Marialetizia , Crocetta Fabio , Santoro Mario 
Published: March 2024

AbstractAppropriate diagnoses of parasites of apex marine predators are crucial to understand their biodiversity, host specificity, biogeography, and life cycles. Such diagnoses are also informative of ecological and biological characteristics of both host and environment in which the hosts and their parasites live. We here (i) investigate the parasite fauna of a bluntnose sixgill sharkHexanchus griseus(Bonnaterre, 1788) obtained from the Gulf of Naples (Tyrrhenian Sea), (ii) characterize molecularly all its metazoan parasites, and (iii) resurrect and report the main morphological features and phylogenetic position ofGrillotia acanthoscolex, a cestode species previously synonymized withGrillotia adenoplusia. A rich parasite fauna represented by eight different taxa was found, including two monogeneans (Protocotyle griseaandProtocotyle taschenbergi), one digenean (Otodistomum veliporum), four cestodes (Crossobothrium dohrnii,Clistobothriumsp.,G. acanthoscolex, andG. adenoplusia), and one copepod (Protodactylina pamelae). Sequencing of these samples accounts for an important molecular baseline to widen the knowledge on the parasitic fauna of bluntnose sixgill sharks worldwide and to reconstruct their correct food chains. The bluntnose sixgill shark was found to be a definitive host for all endoparasites found here, confirming that it occupies an apex trophic level in the Mediterranean Sea. The taxa composition of the trophic parasite fauna confirms that the bluntnose sixgill shark mostly feeds on teleost fish species. However, the occurrence of two phillobothrid cestodes (C. dohrniiandClistobothriumsp.) suggests that it also feeds on squids. Finally, we emphasize the importance of using integrative taxonomic approaches in the study of parasites from definitive and intermediate hosts to elucidate biology and ecology of taxa generally understudied in the Mediterranean Sea.
Expansion and improvement of ChinaMu by MuT‐seq and chromosome‐level assembly of theMu‐starter genome
Authors: Liang Lei , Wang Yuancong , Han Yanbin , Chen Yicong , Li Mengfei , Wu Yibo , Ma Zeyang , Zhao Han , Song Rentao 
Published: March 2024

ABSTRACTChinaMu is the largest sequence‐indexedMutator(Mu) transposon insertional library in maize (Zea mays). In this study, we made significant improvements to the size and quality of the ChinaMu library. We developed a newMu‐tag isolation method Mu‐Tn5‐seq (MuT‐seq). Compared to the previous method used by ChinaMu, MuT‐seq recovered 1/3 more germinal insertions, while requiring only about 1/14 of the sequencing volume and 1/5 of the experimental time. Using MuT‐seq, we identified 113,879 germinal insertions from 3,168Mu‐active F1families. We also assembled a high‐quality genome for theMu‐active lineMu‐starter, which harbors the initial active MuDR element and was used as the pollen donor for the mutation population. Using theMu‐starter genome, we recovered 33,662 (15.6%) additional germinal insertions in 3,244 (7.4%) genes in theMu‐starter line. TheMu‐starter genome also improved the assignment of 117,689 (54.5%) germinal insertions. The newly upgraded ChinaMu dataset currently contains 215,889 high‐quality germinal insertions. These insertions cover 32,224 pan‐genes in theMu‐starter and B73Ref5 genomes, including 23,006 (80.4%) core genes shared by the two genomes. As a test model, we investigatedMuinsertions in the pentatricopeptide repeat (PPR) superfamily, discovering insertions for 92% (449/487) ofPPRgenes in ChinaMu, demonstrating the usefulness of ChinaMu as a functional genomics resource for maize.
Revitalizing the lower face: Therapeutic insights and an innovative treatment guideline for jowl rejuvenation
Authors: Magacho‐Vieira Fabiano Nadson , Bezerra Luíza Jorgiana Riotinto , Boro Daniel , Santos Fernanda Araújo 
Published: March 2024

AbstractBackgroundThe intricate mechanisms of jowl formation, which ultimately lead to loss of lower jaw definition, skin laxity, and localized fat accumulation, involve interrelated factors such as skin aging, fat redistribution, muscle dynamics, and loss of support.AimsTo propose a structured approach to the treatment of the jowl area that is comprehensive and tailored to the needs of each individual patient.Materials and MethodsThis integrative review combines a meticulous analysis of the literature with practical insights from real‐world clinical settings. The authors draw on their extensive clinical experience to bridge research findings with practical clinical perspectives.ResultsThis study presents a guideline for addressing jowl formation that starts with the major aging processes and, based on simple diagnostic questions, suggests minimally invasive interventions, including collagen stimulators, energy‐based devices, lipolytic injectables, polydioxanone threads, and hyaluronic acid fillers.DiscussionThe guideline emphasizes the significance of personalized treatments while also acknowledging the need for comprehensive evaluation and recognizing the ever‐evolving nature of aesthetic interventions in jowl management.ConclusionThis systematic approach can not only simplify diagnostic and treatment decisions for dermatologists but also enhance patient satisfaction by customizing treatment plans based on individual characteristics and expectations.
Metapolitical seduction: Women's language and white nationalism
Authors: Tebaldi Catherine 
Published: March 2024

AbstractThis paper examines the enregisterment of white nationalist women's language as metapolitical seduction, in anti‐feminist conversion videos designed both to seduce men and to restore them to their proper place—above women. First, the paper analyzes the metapragmatics of submissive femininity, then the characters this far right fairy tale invents, and finally how they come to represent a metapolitical order which aligns gender, nation, tradition, and language. Women's language contributes to the white nationalist metapolitical project of resurrecting white masculinity and re‐gendering the world, also revealing mechanisms by which white supremacy is made to appear not only normal, but desirable.
I am home. The circle is complete: The reunification of fostered/adopted relatives
Authors: Landers Ashley L. , Danes Sharon M. , Morgan Amy A. , Simpson Jessica E. , Merritt Shamora , Hawk Sandy White 
Published: March 2024

AbstractObjectiveThis study examined the underlying, unseen meanings accompanying the progressive verification of the reunification process experienced by American Indian fostered/adopted relatives who were separated from family of origin as children.BackgroundReunification is most often explored as an outcome (i.e., a result) and few studies examine the process of reunification (i.e., what happens or what facilitates it) or the underlying meaning of the reunification process for American Indian fostered/adopted relatives.MethodA secondary data analysis was conducted on survey data from the Experiences of Adopted and Fostered Individuals Project. The sample consisted of 70 American Indian relatives who were fostered/adopted as children and reunified as adults. Thematic analysis was conducted on open‐ended survey data.ResultsFour themes emanated from the data including: (1) searching, (2) facilitating, (3) calling home, and (4) repatriating. Participants searched for their families of origin using information and records (i.e., names of birth family, birth/adoption records). Reunification was facilitated by agencies, hired professionals, courts, and tribes. Relatives were called home by family, tribe, and ancestors. They repatriated through mail, phone, social media, and registries.ConclusionThis study contributed to the literature by using place identity theory to understand the progressive nature of the perceptions and comprehensions experienced by American Indian relatives during the reunification process. Place identity verification undergirds the process of reunification for American Indian fostered/adopted relatives including the underlying, unseen meanings that accompany the reunification process.
Testimonios on participatory action research as a critical race approach to studying Southeast Asian american Refugee subjects
Authors: Nguyen Angela‐MinhTu D. , Huynh Que‐Lam , Chang Richard , Lieng Nathan 
Published: March 2024

AbstractInstead of being agents of inquiry and change, Southeast Asian American (SEAA; Viet, Hmong, Lao, Cambodian) refugee subjects are often objectified and essentialized by researchers in the social sciences. In this article, we document our collaborative journeys to unlearn colonial and racist ways of thinking about and conducting research on marginalized communities, including our own SEAA communities. Specifically, we present participatory action research (PAR) and testimonios—two examples of counter‐storytelling—as promising critical race methodologies. Using PAR, our team of academic researchers and participant‐researchers collaborated on research to create change in our communities. To assess our experiences with PAR, we used testimonios to share our self‐reflections and stories on the research process and the training relationship. We end by offering suggestions for using PAR and testimonios to engage in anti‐colonial and anti‐racist research.
‘Patient’ or ‘professional’? Negotiating accommodations and identity in fieldwork education
Authors: Edelist Tracey , Zaman Shahbano , Katzman Erika , Jarus Tal 
Published: March 2024

AbstractIntroductionDespite legislation mandating accommodation policies in postsecondary education, support for students with disabilities is often not implemented within health and human services (HHS) education programs, particularly in fieldwork settings. As part of a Canada‐wide study exploring the experiences of disabled students in 10 HHS programs, we examined how HHS students described their experiences accessing accommodations in fieldwork to understand how conceptions of disability relate to students' fieldwork experiences. Using a critical disability studies framework, we explored how HHS fieldwork education understands disability, accommodations and professional competence and what those understandings reveal about the discrepancy between mandated accommodations and what happens in practice.MethodsThirty‐five students requiring accommodations in HHS fieldwork education participated in interviews. Through a critical interpretive analysis of interview data, we developed first‐person composite narratives to show the richness and complexity of the students' diverse, yet similar, subjective experiences with fieldwork accommodations.FindingsTwo composite narratives demonstrate how conceptions of disability incommensurate with professional competence expectations influenced student experiences with disclosing disability and obtaining accommodations in fieldwork. Fear of stigma and having one's competence questioned, or having accommodation requests denied for being misaligned with professional expectations, demonstrate how HHS fieldwork education and practice are upheld by ableist systemic structures.DiscussionThe dominant medical model of disability in HHS education creates institutional barriers that require students to constantly (re)construct their ‘professional’ identity in relation to their ‘patient’ identity. This patient–professional identity construction relates to HHS professional competency standards and assumptions about what makes a ‘good’ professional. Suggestions include reworking competency standards and implementing critical pedagogical approaches to teach future and current HHS professionals to question both personal and practice assumptions. With institutional backing, such changes may support diversity within HHS and a culture shift toward more equitable education and health care.
Influence of the gut and airway microbiome on asthma development and disease
Authors: Smulders Tamar , Van Der Schee Marc P. , Maitland‐Van Der Zee Anke H. , Dikkers Frederik G. , Van Drunen Cornelis M. 
Published: March 2024

AbstractThere are ample data to suggest that early‐life dysbiosis of both the gut and/or airway microbiome can predispose a child to develop along a trajectory toward asthma. Although individual studies show clear associations between dysbiosis and asthma development, it is less clear what (collection of) bacterial species is mechanistically responsible for the observed effects. This is partly due to issues related to the asthma diagnosis and the broad spectrum of anatomical sites, sample techniques, and analysis protocols that are used in different studies. Moreover, there is limited attention for potential differences in the genetics of individuals that would affect the outcome of the interaction between the environment and that individual. Despite these challenges, the first bacterial components were identified that are able to affect the transcriptional state of human cells, ergo the immune system. Such molecules could in the future be the basis for intervention studies that are now (necessarily) restricted to a limited number of bacterial species. For this transition, it might be prudent to develop an ex vivo human model of a local mucosal immune system to better and safer explore the impact of such molecules. With this approach, we might move beyond association toward understanding of causality.
Cohort profile: The Assessing Imperial Valley Respiratory Health and the Environment (AIRE) study
Authors: Farzan Shohreh F. , Kamai Elizabeth , Duenas Barahona Dayane , Ornelas Yoshira Van Horne , Zuidema Christopher , Wong Michelle , Torres Christian , Bejarano Esther , Seto Edmund , English Paul , Olmedo Luis , Johnston Jill 
Published: March 2024

AbstractBackgroundThe Children's Assessing Imperial Valley Respiratory Health and the Environment (AIRE) study is a prospective cohort study of environmental influences on respiratory health in a rural, southeastern region of California (CA), which aims to longitudinally examine the contribution of a drying saline lake to adverse health impacts in children.ObjectivesThis cohort was established through a community–academic partnership with the goal of assessing the health effects of childhood exposures to wind‐blown particulate matter (PM) and inform public health action. We hypothesize that local PM sources are related to poorer children's respiratory health.PopulationElementary school children in Imperial Valley, CA.DesignProspective cohort study.MethodsBetween 2017 and 2019, we collected baseline information on 731 children, then follow‐up assessments yearly or twice‐yearly since 2019. Data have been collected on children's respiratory health, demographics, household characteristics, physical activity and lifestyle, via questionnaires completed by parents or primary caregivers. In‐person measurements, conducted since 2019, repeatedly assessed lung function, height, weight and blood pressure. Exposure to air pollutants has been assessed by multiple methods and individually assigned to participants using residential and school addresses. Health data will be linked to ambient and local sources of PM, during and preceding the study period to understand how spatiotemporal trends in these environmental exposures may relate to respiratory health.Preliminary ResultsAnalyses of respiratory symptoms indicate a high prevalence of allergies, bronchitic symptoms and wheezing. Asthma diagnosis was reported in 24% of children at enrolment, which exceeds both CA state and US national prevalence estimates for children.ConclusionsThe Children's AIRE cohort, while focused on the health impacts of the drying Salton Sea and air quality in Imperial Valley, is poised to elucidate the growing threat of drying saline lakes and wind‐blown dust sources to respiratory health worldwide, as sources of wind‐blown dust emerge in our changing climate.
Crisis, what crisis? The National Health Service since 1948
Authors: Stewart John 
Published: March 2024

AbstractThis article examines the history of the National Health Service from the perspective of the ‘crises’ it has experienced almost continuously since its foundation in 1948. Three themes are examined: scientific revolution, professional bodies, and, especially, political economy. A concluding discussion suggests that there is scope for rethinking how we envisage the NHS, and the ends it pursues.
Micropulse transscleral cyclophotocoagulation in canine glaucoma: A retrospective study evaluating sweep velocity
Authors: Benitez‐Vera Valeria , Bras Dineli , Montiani‐Ferreira Fabiano 
Published: March 2024

AbstractObjectiveTo report preliminary results of MP‐TSCP in canine patients with glaucoma while evaluating sweep velocity, treatment efficacy, and safety utilizing standardized surgical parameters.Animal studiedClient‐owned dogs that underwent MP‐TSCP at a veterinary referral hospital.ProcedureMedical records of 19 eyes (14 dogs) treated with MP‐TSCP were reviewed. Eleven eyes were treated with a 10 s/sweep (s) velocity and 8 eyes with a 20 s/s. Laser duty cycle was set at 31.3%, mean laser energy was 2766 mW, and mean duration was 120 s per hemisphere. Minimum post‐operative follow‐up was 6 months. Outcomes of intraocular pressure (IOP), vision status, degree of antiglaucoma medications, and complications were evaluated.ResultsThere was a significantly lower median (IQR) IOP (<25 mmHg) at each timepoint postoperatively compared to IOP pre‐operatively (p < 0.05). The overall success rate for IOP control at 6 months was 84%, 100% for the 10 s/s and 62.5% for the 20 s/s. Vision was preserved in 10/11 (90%) eyes from the 10 s/s group and 4/8 (50%) eyes from the 20 s/s group at 6 months. Average number of glaucoma medications in the 10 s/s group decreased from 4.4 to 1.5 and from 3.3 to 2.5 in the 20 s/s group. Post‐operative complications were mild and resolved within 1 week.ConclusionsMP‐TSCP is a non‐invasive treatment alternative for canine glaucoma. Employing higher energy levels rendered long‐term IOP control while retaining a high safety profile with minimal postoperative complications. There was no statistical difference between a 10 s/s and 20 s/s surgical velocity, both leading to successful surgical outcomes up to 6 months post‐operatively.