Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Authors: Wannan Cassandra M J , Nelson Barnaby , Addington Jean , Allott Kelly , Anticevic Alan , Arango Celso , Baker Justin T , Bearden Carrie E , Billah Tashrif , Bouix Sylvain , Broome Matthew R , Buccilli Kate , Cadenhead Kristin S , Calkins Monica E , Cannon Tyrone D , Cecci Guillermo , Chen Eric Yu Hai , Cho Kang Ik K , Choi Jimmy , Clark Scott R , Coleman Michael J , Conus Philippe , Corcoran Cheryl M , Cornblatt Barbara A , Diaz-Caneja Covadonga M , Dwyer Dominic , Ebdrup Bjørn H , Ellman Lauren M , Fusar-Poli Paolo , Galindo Liliana , Gaspar Pablo A , Gerber Carla , Glenthøj Louise Birkedal , Glynn Robert , Harms Michael P , Horton Leslie E , Kahn René S , Kambeitz Joseph , Kambeitz-Ilankovic Lana , Kane John M , Kapur Tina , Keshavan Matcheri S , Kim Sung-Wan , Koutsouleris Nikolaos , Kubicki Marek , Kwon Jun Soo , Langbein Kerstin , Lewandowski Kathryn E , Light Gregory A , Mamah Daniel , Marcy Patricia J , Mathalon Daniel H , McGorry Patrick D , Mittal Vijay A , Nordentoft Merete , Nunez Angela , Pasternak Ofer , Pearlson Godfrey D , Perez Jesus , Perkins Diana O , Powers Albert R , Roalf David R , Sabb Fred W , Schiffman Jason , Shah Jai L , Smesny Stefan , Spark Jessica , Stone William S , Strauss Gregory P , Tamayo Zailyn , Torous John , Upthegrove Rachel , Vangel Mark , Verma Swapna , Wang Jijun , Rossum Inge Winter-van , Wolf Daniel H , Wolff Phillip , Wood Stephen J , Yung Alison R , Agurto Carla , Alvarez-Jimenez Mario , Amminger Paul , Armando Marco , Asgari-Targhi Ameneh , Cahill John , Carrión Ricardo E , Castro Eduardo , Cetin-Karayumak Suheyla , Mallar Chakravarty M , Cho Youngsun T , Cotter David , D’Alfonso Simon , Ennis Michaela , Fadnavis Shreyas , Fonteneau Clara , Gao Caroline , Gupta Tina , Gur Raquel E , Gur Ruben C , Hamilton Holly K , Hoftman Gil D , Jacobs Grace R , Jarcho Johanna , Ji Jie Lisa , Kohler Christian G , Lalousis Paris Alexandros , Lavoie Suzie , Lepage Martin , Liebenthal Einat , Mervis Josh , Murty Vishnu , Nicholas Spero C , Ning Lipeng , Penzel Nora , Poldrack Russell , Polosecki Pablo , Pratt Danielle N , Rabin Rachel , Rahimi Eichi Habiballah , Rathi Yogesh , Reichenberg Avraham , Reinen Jenna , Rogers Jack , Ruiz-Yu Bernalyn , Scott Isabelle , Seitz-Holland Johanna , Srihari Vinod H , Srivastava Agrima , Thompson Andrew , Turetsky Bruce I , Walsh Barbara C , Whitford Thomas , Wigman Johanna T W , Yao Beier , Yuen Hok Pan , Ahmed Uzair , Byun Andrew (Jin Soo) , Chung Yoonho , Do Kim , Hendricks Larry , Huynh Kevin , Jeffries Clark , Lane Erlend , Langholm Carsten , Lin Eric , Mantua Valentina , Santorelli Gennarina , Ruparel Kosha , Zoupou Eirini , Adasme Tatiana , Addamo Lauren , Adery Laura , Ali Munaza , Auther Andrea , Aversa Samantha , Baek Seon-Hwa , Bates Kelly , Bathery Alyssa , Bayer Johanna M M , Beedham Rebecca , Bilgrami Zarina , Birch Sonia , Bonoldi Ilaria , Borders Owen , Borgatti Renato , Brown Lisa , Bruna Alejandro , Carrington Holly , Castillo-Passi Rolando I , Chen Justine , Cheng Nicholas , Ching Ann Ee , Clifford Chloe , Colton Beau-Luke , Contreras Pamela , Corral Sebastián , Damiani Stefano , Done Monica , Estradé Andrés , Etuka Brandon Asika , Formica Melanie , Furlan Rachel , Geljic Mia , Germano Carmela , Getachew Ruth , Goncalves Mathias , Haidar Anastasia , Hartmann Jessica , Jo Anna , John Omar , Kerins Sarah , Kerr Melissa , Kesselring Irena , Kim Honey , Kim Nicholas , Kinney Kyle , Krcmar Marija , Kotler Elana , Lafanechere Melanie , Lee Clarice , Llerena Joshua , Markiewicz Christopher , Matnejl Priya , Maturana Alejandro , Mavambu Aissata , Mayol-Troncoso Rocío , McDonnell Amelia , McGowan Alessia , McLaughlin Danielle , McIlhenny Rebecca , McQueen Brittany , Mebrahtu Yohannes , Mensi Martina , Hui Christy Lai Ming , Suen Yi Nam , Wong Stephanie Ming Yin , Morrell Neal , Omar Mariam , Partridge Alice , Phassouliotis Christina , Pichiecchio Anna , Politi Pierluigi , Porter Christian , Provenzani Umberto , Prunier Nicholas , Raj Jasmine , Ray Susan , Rayner Victoria , Reyes Manuel , Reynolds Kate , Rush Sage , Salinas Cesar , Shetty Jashmina , Snowball Callum , Tod Sophie , Turra-Fariña Gabriel , Valle Daniela , Veale Simone , Whitson Sarah , Wickham Alana , Youn Sarah , Zamorano Francisco , Zavaglia Elissa , Zinberg Jamie , Woods Scott W , Shenton Martha E 
Published: March 2024

Abstract
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.