bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental approaches to microarray analysis of tumor samples
Authors: Furge Laura Lowe , Winter Michael B. , Meyers Jacob I. , Furge Kyle A. 
Published: March 2008

AbstractComprehensive measurement of gene expression using high‐density nucleic acid arrays (i.e. microarrays) has become an important tool for investigating the molecular differences in clinical and research samples. Consequently, inclusion of discussion in biochemistry, molecular biology, or other appropriate courses of microarray technologies has become essential in training the modern scientist. The following article offers preparatory and problem‐solving questions for engaging students in the understanding of microarray technologies for use in conjunction with other course materials relating to discussions of microarray technology.
Measuring intracellular enzyme concentrations
Authors: Miranda Hugo Vicente , Ferreira António E. N. , Quintas Alexandre , Cordeiro Carlos , Freire Ana Ponces 
Published: March 2008

AbstractEnzymology is one of the fundamental areas of biochemistry and involves the study of the structure, kinetics, and regulation of enzyme activity. Research in this area is often conducted with purified enzymes and extrapolated to in vivo conditions. The specificity constant, kS, is the ratio between kcat (the catalytic constant) and Km (Michaelis–Menten constant), and expresses the efficiency of an enzyme as a catalyst. This parameter is usually determined for purified enzymes, and in this work, we propose a classroom experiment for its determination in situ, in permeabilized yeast cells, based on a method of external enzyme addition, which was previously reported. Under these conditions, which resemble the in vivo state, enzyme concentrations and protein interactions are preserved. The students are presented with a novel approach in enzymology, based on the titration methods that allow the measurement of the enzyme amount, and thus the kcat and kS. The method will also be used to investigate the effect of exposure to oxidative stress conditions on yeast glyoxalase I.
Rapid screening of polysaccharide‐based plasma volume expanders dextran and hydroxyethyl starch in human urine by liquid chromatography–tandem mass spectrometry
Authors: Guddat Sven , Thevis Mario , Thomas Andreas , Schänzer Wilhelm 
Published: March 2008

AbstractThe increasing number of samples and target substances in doping control requires continuously improved screening methods, combining high‐throughput analysis, simplified sample preparation, robustness and reliability. Hence, a rapid screening procedure based on liquid chromatography–electrospray ionization–tandem mass spectrometry with in‐source collision‐induced dissociation was developed. The detection of the polysaccharide‐based plasma volume expanders dextran and hydroxyethyl starch (HES) in human urine was established without further sample preparation. The in‐source fragmentation strategy of the approach represented a valuable tool in the analysis of the polysaccharide‐based compounds, allowing the use of tandem mass spectrometry. After direct injection of urine specimens, analytes were chromatographically separated on a monolithic reverse‐phase column and detected via multiple reaction monitoring of diagnostic ions at detection limits of 10 µg/mL for HES and 30 µg/mL for dextran. Validation was performed regarding the parameters specificity, linearity, precision (8–18%) and accuracy (77–105%) and the method was applied to the investigation of approximately 400 doping control samples and seven dextran and two hydroxyethyl starch post‐administration samples. The approach demonstrated its capability as a rapid screening tool for the detection of dextran and hydroxyethyl starch and represents an alternative to existing screening procedures since time consuming hydrolysis or derivatization steps were omitted. Copyright © 2008 John Wiley & Sons, Ltd.
Accessory muscles in the lower part of the anterior compartment of the arm that may entrap neurovascular elements
Authors: Paraskevas G. , Natsis K. , Ioannidis O. , Papaziogas B. , Kitsoulis P. , Spanidou S. 
Published: March 2008

AbstractThe aim of this study was to evaluate the incidence of abnormal muscular bands of the anterior compartment of the arm that may compress the median, the ulnar, and the medial antebrachial cutaneous nerve as well as the brachial artery and vein, thus causing entrapment at and above the elbow. A total of 56 adult cadavers were studied during routine dissections that occurred in our laboratory. In the 112 upper limbs studied, we found three variant muscles of the flexor compartment of the arm (2.68%) entrapping nerves and vessels. The first muscle was emerging from the tendon of long head of biceps brachii and coracobrachialis muscle insertion. The second muscle inserted partially into the belly of biceps brachii and should be considered as a supernumenary head of biceps brachii. The third muscle, in fact, represents an accessory fascicle of the brachialis muscle that is an embryonic remnant of that muscle. A number of structures cross anterior to the median, ulnar, and medial antebrachial cutaneous nerve as well as the brachial artery and vein. Compression of nerves and vessels may be caused by additional muscular bundles that pass anterior to these structures. These additional muscular bundles arise either from the brachialis, coracobrachialis, or biceps brachii muscle. Such variations have clinical implications and should be considered in patients, with a high median or ulnar or medial antebrachial cutaneous nerve paralysis with symptoms of lower brachial artery or brachial vein compression. Clin. Anat. 21: 246–251, 2008. © 2008 Wiley‐Liss, Inc.
Testing panel consistency with GCAP method in food profile analysis
Authors: Kollár‐Hunek K. , Heszberger J. , Kókai Z. , Láng‐Lázi M. , Papp E. 
Published: March 2008

AbstractThe analysis of descriptive sensory data is a very complex task in food product development and in food quality management. One of the key issues is the reliability of the panel members in making decisions. The authors created a software – the ProfiSens, based on Visual Basic for Excel (VBE) – for the IT support of food profile analysis. Using this software we have developed a method for testing panel consistency. This method is based on the geometrical properties of the profile polygon. It offers a fast and expressive way for the qualification of the panel, and the authors created its VBE implementation, too, that can be easily linked to the basic ProfiSens software. In this paper we discuss the mathematical background and the algorithm of the method in every detail, and we show several applications in the fields of research, education and industry. Copyright © 2008 John Wiley & Sons, Ltd.
2H NMR Studies on Two‐Homopolypeptide Lyotropic Enantiodiscriminating Mesophases: Experimental Quantification of Solute–Fiber Affinities
Authors: Lesot Philippe , Lafon Olivier , Aroulanda Christie , Dong Ronald Y. 
Published: March 2008

AbstractThe analytical potential and enantioselective properties of lyotropic mesophases made by mixing two chemically different chiral polypeptides are described. Here we examine the case of a mixture of poly‐γ‐benzyl‐L‐glutamate (PBLG) and poly‐ε‐carbobenzyloxy‐L‐lysine (PCBLL). We demonstrate that 2H NMR spectroscopy on these chiral oriented mixtures can discriminate both enantiomers and enantiotopic directions in prochiral molecules. Moreover, in such systems, degree of enantiodiscrimination, resolution, and sensitivity can be conjointly optimized by changing the relative proportion of the two polypeptides. Therefore, these new enantiodiscriminating media provide a favorable alternative to single‐polypeptide mesophases with respect to stereochemical applications. At a more fundamental level, the present work points out that solute distribution in the vicinity of each polypeptide partly governs the degree of enantiodiscrimination and NMR relaxation rates. To this end, the experimental trends of solute NMR observables (ΔνQ, T1) versus the fraction of peptide units of each polymer were analyzed by using a “mean‐field” model derived from that proposed for mixtures of thermotropic nematic solvents, and based on the separation of intermolecular interactions between the solute and both polypeptides. This approach allows the relative solute–fiber affinities in these lyotropic systems to be determined. To identify the factors controlling solute–polypeptide affinities, we investigated various solutes (polar/apolar, rigid/flexible, achiral/prochiral/chiral molecules) using 2H NMR at natural abundance or on isotopically enriched solutes.
Self‐Assembled 3D Architectures of LuBO3:Eu3+: Phase‐Selective Synthesis, Growth Mechanism, and Tunable Luminescent Properties
Authors: Yang Jun , Li Chunxia , Zhang Xiaoming , Quan Zewei , Zhang Cuimiao , Li Huaiyong , Lin Jun 
Published: March 2008

AbstractRhombohedral‐calcite and hexagonal‐vaterite types of LuBO3:Eu3+ microparticles with various complex self‐assembled 3D architectures have been prepared selectively by an efficient surfactant‐ and template‐free hydrothermal process for the first time. X‐ray diffraction, scanning electron microscopy, energy‐dispersive X‐ray spectrometry, transmission electron microscopy, high‐resolution transmission electron microscopy, selected area electron diffraction, photoluminescence, and cathodoluminescence spectra as well as kinetic decays were used to characterize the samples. The pH, temperature, concentration, solvent, and reaction time have a crucial influence on the phase formation, shape evolution, and microstructure. The reaction mechanism is considered as a dissolution/precipitation process; it is proposed that the self‐assembly evolution occurs by homocentric layer‐by‐layer growth. Under UV excitation and low‐voltage electron beam excitation, calcite‐type LuBO3:Eu3+ particles show a strong orange emission corresponding to the 5D0→7F1 transition of Eu3+ whereas vaterite‐type LuBO3:Eu3+ particles exhibit a strong red emission with much higher R/O values (that is, chromatically redder fluorescence than that of crystals grown from a direct solid‐state reaction). The tunable luminescent properties have potential applications in fluorescent lamps and field emission displays.
Homo‐ and Heterodimetallic Geminal Dianions Derived from the Bis(phosphinimine) {Ph2P(NSiMe3)}2CH2 and the Alkali Metals Li, Na, and K
Authors: Hull Katherine L. , Carmichael Ian , Noll Bruce C. , Henderson Kenneth W. 
Published: March 2008

AbstractThe geminal organodimetallic complexes [({Ph2P(NSiMe3)}2C)2M4], where M4=Na4, 3; Li2Na2, 4; LiNa3, 5; Li2K2, 6; Na2K2, 7, and Na3K, 8, have been prepared through a variety of methods including direct or sequential deprotonation of the neutral ligand with strong bases (tBuLi, nBuNa, (Me3Si)2NNa, PhCH2K or (Me3Si)2NK), transmetalation of the homometallic derivatives (M4=Li4, 2 or Na4, 3) with tBuONa or tBuOK, and by cation exchange upon mixing the homometallic complexes in an arene solution. Complexes 3–8 have been characterized by single‐crystal X‐ray diffraction and are found to form a homologous series of dimeric structures in the solid‐state, in accord with the previously reported structure of 2. Each complex is composed of a plane of four metals, M4, in which the ligands adopt capping positions to form distorted M4C2 octahedral cores. The metals in homometallic complexes 2 and 3 define an approximate square, whereas the heterometallic derivatives 4–8 have distinctly rhombic arrangements. The lighter metals in 4–8 interact strongly with the carbanions and the heavier metals are pushed towards the periphery of the structures. 1H, 13C, 7Li, 31P, and 29Si multinuclear NMR spectroscopic studies, cryoscopic measurements, and electrospray ionization‐mass spectroscopic studies are consistent with the dimers being retained in solution. Dynamic solution behavior was discovered for Li2Na2 complex 4, in which all five possible tetrametallic derivatives Li4, Li3Na, Li2Na2, LiNa3 and Na4 coexist. Density functional theory (DFT) and natural bond order (NBO) calculations in association with natural population analyses (NPA) reveal significant differences in the electronic structures of the variously metalated dianions. The smaller cations are more effective in localizing the double negative charge on the carbanion (in the form of two lone pairs), leading to differences in the distribution of the electron density within the ligand backbones. In turn, a complex interplay of hyperconjugation, electrostatics and metal‐ligand interactions is found to control the resulting electronic structures of the geminal organodimetallic complexes.
ChemInform Abstract: Analysis of the Spin Lattice Model for the Spin‐Gapped Layered Compounds Na3Cu2SbO6 and Na2Cu2TeO6 on the Basis of Electronic Structure Calculations.
Authors: Koo Hyun‐Joo , Whangbo Myung‐Hwan 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structural, Magnetic and Electrical Properties of La1‐xCdxMnO3 Manganites (0.1 ≤ x ≤ 0.5).
Authors: Dhahri A. , Dhahri J. , Zemni S. , Oumezzine M. , Said M. , Vincent H. 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Active Chiral Phosphoramide—Zn(II) Complexes as Conjugate Acid—Base Catalysts for Enantioselective Organozinc Addition to Ketones.
Authors: Hatano Manabu , Miyamoto Takashi , Ishihara Kazuaki 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Bicyclic Guanidine as a Versatile Broensted Base Catalyst for the Enantioselective Michael Reactions of Dithiomalonates and β‐Keto Thioesters.
Authors: Ye Weiping , Jiang Zhiyong , Zhao Yujun , Goh Serena Li Min , Leow Dasheng , Soh Ying‐Teck , Tan Choon‐Hong 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Class of Acetophenone‐Based Cinchona Alkaloids as Phase‐Transfer Catalysts: Application to the Enantioselective Synthesis of α‐Amino Acids.
Authors: Lv Jian , Zhang Liping , Liu Lei , Wang Yongmei 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclometalated Platinum(II) Complexes Derived from a Chiral Pyridine Ligand: Synthesis, Structure, and Catalytic Activity.
Authors: Yoon Myeong Sik , Ryu Dowook , Kim Jeongryul , Ramesh Rengan , Ahn Kyo Han 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bismesitylmagnesium: A Thermally Stable and Non‐Nucleophilic Carbon‐Centered Base Reagent for the Efficient Preparation of Silyl Enol Ethers.
Authors: Kerr William J. , Watson Allan J. B. , Hayes Douglas 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oligoarene Strategy for Catalyst Development. Hydroxylated Oligoarene‐Type Phosphines for Palladium‐Catalyzed Cross Coupling.
Authors: Ishikawa Shunpei , Manabe Kei 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Bis(alkoxycarbonylation) Reaction of Cyclic Olefins Catalyzed by Palladium in the Presence of Copper(I) Triflate.
Authors: Aratani Takahiro , Tahara Kenji , Takeuchi Susumu , Ukaji Yutaka , Inomata Katsuhiko 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopropyl Building Blocks for Organic Synthesis. Part 145. Ruthenium‐Catalyzed Transformations of Cyclopropylethynes.
Authors: Emme Ingo , Bruneau Christian , Dixneuf Pierre H. , Militzer Hans‐Christian , de Meijere Armin 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Imine Cinnamylation with a Remarkable Diastereochemical Switch.
Authors: Huber John D. , Leighton James L. 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbonylative Addition of Arylboronic Acids to Terminal Alkynes: A New Catalytic Access to α,β‐Unsaturated Ketones.
Authors: Dheur Julien , Sauthier Mathieu , Castanet Yves , Mortreux Andre 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Spirobitetraline Phosphoramidite Ligands and Their Application in Rhodium‐Catalyzed Asymmetric Hydrogenation.
Authors: Huo Xiang‐Hong , Xie Jian‐Hua , Wang Qiu‐Shi , Zhou Qi‐Lin 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rh‐Catalyzed Asymmetric Hydrogenation of γ‐Phthalimido‐Substituted α,β‐Unsaturated Carboxylic Acid Esters: An Efficient Enantioselective Synthesis of β‐Aryl‐γ‐amino Acids.
Authors: Deng Jun , Duan Zheng‐Chao , Huang Jia‐Di , Hu Xiang‐Ping , Wang Dao‐Yong , Yu Sai‐Bo , Xu Xue‐Feng , Zheng Zhuo 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Preparation of N‐Phenylsulfenyl Ketimines from Oximes or Nitro Compounds Without Racemization of α‐Stereocenters.
Authors: Bures Jordi , Isart Carles , Vilarrasa Jaume 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Enantioselective Cascade Michael—Aldol Condensation Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes.
Authors: Wang Jian , Li Hao , Xie Hexin , Zu Liansuo , Shen Xu , Wang Wei 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselective Synthesis of Tetrahydrofurans via Mead Reductive Cyclization of Keto‐β‐Lactones Derived from the Tandem Mukaiyama Aldol Lactonization (TMAL) Process.
Authors: Mitchell T. Andrew , Romo Daniel 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Yielding Palladium‐Catalyzed Intramolecular Alkane Arylation: Reaction Development and Mechanistic Studies.
Authors: Lafrance Marc , Gorelsky Serge I. , Fagnou Keith 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mo‐Catalyzed Regio‐, Diastereo‐, and Enantioselective Allylic Alkylation of 3‐Aryloxindoles.
Authors: Trost Barry M. , Zhang Yong 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Tandem Cross‐Coupling/SNAr Approach to Functionalized Carbazoles.
Authors: St. Jean David J. Jr. , Poon Steve F. , Schwarzbach Jamie L. 
Published: March 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.