bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular cardiomyoplasty for refractory angina: experimental rationale.
Authors: Gramatiuk Svetlana , Ivanova Yulia , Sargsyan Karine , Kryvoruchko Igor , Estrin Sergii 
Published: March 2024

Abstract

This experimental study aimed to investigate the therapeutic potential of cellular cardiomyoplasty in the context of refractory angina using a rodent model. The study comprised five groups of animals subjected to different interventions, including "empty" injections, autologous mesenchymal stem cell (MSC) injections via various routes, and untreated controls. Stress load modeling was employed to assess the hemodynamic response, mainly focusing on heart rate changes during isopropyl norepinephrine loading.
Results revealed a positive chronotropic effect in all groups, with varying severity. Intact rats exhibited a significant increase in heart rate, while animals in the "empty" injection group demonstrated a less pronounced response. Interestingly, those treated with MSCs, either through direct myocardial injection or intravenous and intracavitary routes, exhibited notable variations in stress-induced heart rate changes. By the third minute of the experiment, a decrease in heart rate was observed across all groups, stabilizing at 490–495 beats/min. Notably, the groups with untreated myocardial infarction and "empty" injections displayed an inability to compensate for required blood flow during stress, indicative of potential challenges in these conditions.
These findings suggest that cellular cardiomyoplasty, particularly with autologous MSCs injected into the myocardium, may influence the stress-induced changes in heart rate. However, a comprehensive evaluation of additional cardiovascular parameters and further exploration of therapeutic outcomes are warranted to elucidate the potential clinical relevance of these observations. This study contributes valuable insights into the experimental rationale and hemodynamic effects of cellular cardiomyoplasty, laying the groundwork for future investigations in refractory angina and myocardial infarction.
Development and application of InDels and SNPs markers based on whole-genome resequencing in Chinese cabbage
Authors: Liu Kai-wen , Men Wan-jie , Feng Jin-xia , Hussain Iqbal , Sheng Hui , Zhang Li-wei , Dai Zhong-ren , Hu Hai-jiang , Yang Jian-hao , Lei Na , Yu Xiao-lin 
Published: March 2024

Abstract
Chinese cabbage (Brassica rapa L. syn. B. campestris L., AA, 2n=20) is highly popular green leafy vegetable in the triangle of U, with China serving as its primary center of origin and diversification. Plant height, rosette leaf diameter, and disease resistance have always been important selection criteria for Chinese cabbage. In this study, we conducted re-sequencing on 55 Chinese cabbage accessions collected from China, Japan and Korea, followed population genetic evolutionary analysis and genome-wide association study (GWAS). Our findings unveiled a lack of significant population structure among these accessions, implying a possible evolutionary link or hybridization between Japanese and Korean Chinese cabbages with their Chinese counterparts. GWAS analysis results revealed that BrASD1, BrZHD13, BrGH3.3, and BrGH3.6 regarded as potential candidate genes highly associated with plant height in Chinese cabbage. Moreover, we also identified two single nucleotide polymorphisms (SNPs) loci associated with rosette leaf diameter and one SNP locus associated with downy mildew resistance, respectively. Furthermore, a novel tightly linked Insertion-deletion (InDel) marker on the end of A04 chromosome in B. rapa, SMB.4, has been developed. And SMB.4 can potentially serve as a useful molecular marker screening the genetic resources with downy mildew resistance and application for the downy mildew resistance breeding of Brassica crops.
Description of an Enterococcus faecium genotype vanB outbreak in a hospitalization ward
Authors: Andrés Marta , Fajardo Anna , Consuelo García María , Grau Laura , Angulo Yesika , Marín Virginia , Plasencia Virginia , Santillana Genoveva , Jiménez Elena , Ballestero Monica 
Published: March 2024

Abstract

Background and objectives: Vancomycin-resistant Enterococcus faecium (VRE) infections have increased in the last years. Hospital outbreaks have been described with a challenging microbiological diagnosis and control of the transmission.
Methods: this is a retrospective study of a nosocomial outbreak of VRE in a conventional hospitalization ward. Three clinical samples of VRE genotype vanB (vanB VRE) were detected in two surgical wards. Epidemiological control measures were implemented, including contact isolation, patients from clean surgery ward transferred to other wards, staff training, weekly screening with rectal swab and environmental study.
Results: in a 3-month follow-up period, rectal screening was performed on a total of 314 patients, being positive for vanB VRE 51 patients (16.2%). A study of the surface of the common areas with exclusive use by healthcare personnel detected vanB VRE in 28% of the samples. All the strains of VRE analyzed by MLST were ST117, which belongs to clonal complex 17. Hand hygiene observations show proper adherence in 56% of the events monitored. Notwithstanding the large number of colonized patients, just one patient had a relevant infection requiring treatment, with good evolution.
Conclusions: the survival of VRE on surfaces and the poor adherence to hand hygiene might have contributed to repetitively infect surfaces, perpetuating the outbreak. Despite its spread, the clinical impact was low, possibly because the outbreak took place in a ward without severe immunosuppressed patients. The frequent isolation of VRE on surfaces which were exclusive from healthcare personnel areas, indicates how important is the disinfection of these areas.
The Myers-Briggs Type Indicator Association with United States Medical Student Performance, Demographics, and Career Values
Authors: Krasner Henry , Yim Leah , Simanton Edward 
Published: March 2024

Abstract

Background
The Myers-Briggs Type Indicator (MBTI) is a self-reported personality test that has continued to gain popularity and traction across industries. The MBTI assesses individuals within four dichotomous categories corresponding to ways to, ultimately, assign one of sixteen personality types. Prior studies indicate that physicians trended towards certain personality traits and medical students with a particular trait performed lower academically. Due to the recency of these studies, however, there is a substantial knowledge gap in the relationship between medical student MBTIs and academic performance, demographics, and career interests. Therefore, the purpose of this study is to investigate this relationship amongst 4-year allopathic U.S. medical students and determine if there is substantial correlation to implement MBTI results in creating personalized student support services in school curriculum.
Methods
This study was a single institution, cross-sectional study. A survey was emailed to all students with the MBTI personality test paper edition, in addition to questions regarding specialty interest, learning style preference, and career values. Each student’s responses were de-identified after pairing with the respective students’ academic performance data and demographic information. Chi-square tests were used to compare MBTI data with categorical data such as demographic characteristics while independent sample t-tests were used to compare MBTI data with numerical variables like academic performance.
Results
Our findings suggest statistically significant associations between Introversion (I) with older age and Thinking (T) with male students. Additionally, Thinking (T) students performed better academically, valued variety in patient care, and the specific type of patient contact. Conversely, Feeling (F) students trended towards people-oriented specialties. Regarding learning styles and study environments, Extroverted (E) and Judging (J) types preferred hands-on learning, though Judging (J) types also preferred a quiet environment. No other statistically significant differences were found amongst the remaining variables.
Conclusion
Medical schools should utilize student MBTI results to individualize student academic and career support as our study indicates various significant associations between some of the personality types. While not a “one-size-fits-all,” the MBTI can be used as a potential starting point for specialty exploration and learning styles.
Risk factor analysis and nomogram for predicting 28-days mortality in ICU patients with sepsis and diabetes
Authors: Yang Changgen , Wang Yuxia , Han Fang , Xu Liang , Xu Kaizhi 
Published: March 2024

Abstract
Background: Diabetes is a common comorbidity in septic patients, often leading to immune dysfunction and metabolic disturbances, associated with an increased mortality rate. Therefore, this study aims to identify risk factors in septic patients with concomitant diabetes, establish a useful predictive model to accurately assess the prognosis, and provide treatment recommendations.
Methods: Data were sourced from the open-access clinical database, Medical Information Mart for Intensive Care (MIMIC-IV). A total of 4252 cases of septic patients with concomitant diabetes were extracted for the study. Participants were randomly divided into training and validation sets in a 7:3 ratio. A predictive nomogram model was constructed in the training set using COX regression analysis. Specificity and sensitivity analyses were conducted using the area under the receiver operating characteristic curve (AUC). Internal validation and evaluation of the nomogram were performed through integrated discrimination improvement (IDI), calibration curve, and decision curve analysis (DCA).
Results:According to the COX regression analysis, factors including Norepinephrine maximum, Temperature, Antibiotic, Heart Rate, SAPS II, Age, BMI, Bilirubin total, Stroke, Troponin, Metastatic solid tumor, and APTT were incorporated into the nomogram. In comparison with the Sequential Organ Failure Assessment (SOFA) and Simplified Acute Physiology Score II (SAPS II), the nomogram demonstrated superior discriminative ability, with AUCs of 0.797 (95% CI: 0.779-0.816) and 0.782 (95% CI: 0.754-0.81) for the training and validation sets, respectively. Decision curve analysis (DCA) of the nomogram showed a net benefit in clinical use compared to the use of SOFA and SAPS II in both groups.
Conclusion: The predictive model in this study exhibits excellent discriminative and calibration abilities in predicting mortality among septic patients with concomitant diabetes. Implementing treatment strategies targeting factors identified in the model could improve the prognosis of these patients.
Use of Speckle Tracking Echocardiography to Predict Right Heart Failure Following Left Ventricular Assist Device Implantation: A Systematic Review and Meta-Analysis
Authors: Frye Jesse , Tao Michael , Dhaliwal Simrat , Tam Edlira , Goldschmidt Marc , Mann Noelle , Kort Smadar 
Published: March 2024

Abstract
Introduction
Right Heart Failure (RHF) is an important consequence of implant of left ventricular assist devices (LVAD). Right ventricular (RV) analysis with speckle tracking echo (STE) can assist in the assessment of the RV. This meta-analysis examines preoperative RV strain on STE as a predictor of postoperative RHF.
Methods
Literature was reviewed in Pubmed, EMBASE, and Web of Science for studies reporting on the association of preoperative RV free wall (FWS), global longitudinal (GLS), and septal longitudinal (SLS) strain with postoperative RV failure following LVAD placement. Strain parameters were compared between the two groups.
Results
A total of 13 studies with 933 patients undergoing LVAD implantation met inclusion criteria. 254 patients subsequently developed RHF and 679 did not develop RHF. Mean follow up was 15 months. The mean age of participants was 55.9 years and 85% were male. Baseline RVFWS, RVGLS, and RVSLS were significantly reduced in patients who developed post-implantation RHF compared to patients who did not develop post-implantation RHF (MD 3.77, 95% CI 2.39, 5.15; p<0.01; MD 2.67, 95% CI 1.16, 4.17; p<0.01; MD 3.59, 95% CI 0.83, 6.35; p=0.01). The heterogeneity was considerable for all three analyses (RVFWS I2=88%, RVGLS I2=92%, RVSLS I2=83%), likely due to vendor-specific differences in strain measurements and differences in echocardiography lab protocols. To address this, a random-effects model was used.
Conclusions
Preoperative RV FWS, GLS, and SLS were all associated with postoperative RHF. STE may be helpful in risk stratification of RHF following LVAD implant.
Evaluation and Correlation of Facial Asymmetry in Adults with Class I, Class II, and Class III Skeletal Relation
Authors: Alruwaili Abdurahman M. , Mowafey Bassant , Elbialy Mohammed A. , Alam Mohammad K. , Tawfik Marwa A. 
Published: March 2024

Abstract

Background The current study with the prime objectives revolved around investigating and evaluating the differences of facial asymmetry in adults who suffer from Class I, Class II, and Class III skeletal relations, and to also evaluate the extent to which soft tissue either accentuate or mask such differences altogether.
Material and methods A total of 225 frontal photographs of adult patients who was attended and was diagnosed in orthodontic department at Al-Mansoura University and were took to evaluate facial asymmetry. The subjects were divided in three groups; namely Group I, II, and III that pertain to Class I, II, and III patients with each Group/Class appointed to 75 participants respectively. Each Group was divided into sub-groups; a and b, for each Class. Digital photos were took using a Canon 600d digital camera.
Result Findings revealed that between Class I and Class III and Class II and Class III the Pronasale point was the only point that caused a statistical significance as opposed to the Labial Superior and Menton points; (p=0.03, p=0.02) respectively. Other statistically significant differences were found among Class I, II, and III groups regarding the distance between mid-facial plane point and the left exocanthus for; (p = 0.012) and regarding the distance between MFP and the left ala for; (p = 0.04).
Conclusion It was concluded that though Class I, II, and III malocclusions may have distinct skeletal differences, the appearance of the soft tissues can obscure the distinctions, creating a seemingly uniform image. Regarding the PN point, it can be concluded that patients who suffer from Class I, Class II and Class III had a wider right hemiface, and that patients who suffer from Class II and Class III had a wider right hemiface regarding both the LS and ME points respectively. Generally speaking, 56%, 52%, and 52% of the subjects had a wider right hemiface regarding the PN, LS, and ME points respectively.
LOS VALORES EN MAESTROS HUELLA DE LA UNIVERSIDAD TÉCNICA DE MACHALA. RELATOS DE VIDA DE DOCENTES UNIVERSITARIOS
Authors: Mendieta Toledo Mao , Mendieta Toledo Lenin Rijkaard , Morán Vázquez Ruth Ericka , Chamba Zambrano Ohn Marcelo , Mendieta Toledo Lenin Byron 
Published: March 2024

El estudio emerge de la investigación FCI-012 Relatos de vida de profesores universitarios. Una aproximación biográfica y narrativa sobre los valores, ética y moral en la enseñanza los docentes de las universidades del Ecuador. El objetivo fue comprender los Valores en Maestros Huella de la Universidad Técnica de Machala, desde sus relatos de vida personal y profesional. Fue una investigación cualitativa interpretativa con énfasis en los relatos biográficos y autobiográficos. Se empleó la encuesta para la selección de los Maestros Huella, la entrevista con un guion semiestructurado, la herramienta ATLAS.ti., para la codificación y construcción de redes rizomáticas y la interpretación hermenéutica. Los resultados señalan que la práctica de los valores es uno de los ejercicios que permiten al hombre atravesar el umbral de ser humano y llegar a ser una persona humana. Los valores como la gratitud, respeto, puntualidad, compasión, otredad, empatía y honestidad, están presentes en el docente Renato Villota, Maestro Huella de la Universidad Técnica de Machala.
Improved theoretical calculation method for the transverse load distribution of wide bridges considering torsion and distortion
Authors: Wen Ji , Ma Xinyi , Jiang Hui , Li Chen , Zeng Cong , Bai Zengqing 
Published: March 2024

An improved theoretical calculation method was proposed to determine the transverse load distribution of airport and highway bridges under heavy loads using the rigid-joint girder (RJG) method. The effects of torsion, distortion, and vertical inclination of the adjacent box girder joints under an eccentric heavy load were considered. The coefficients and influence lines of a taxiway bridge and a highway bridge were calculated using the proposed method, the RJG method, and the modified RJG methods. The accuracies of the three methods were evaluated by the refined finite element model, and the cosine similarity and peak deviation rate were used as quantitative indices. The results showed that the cosine similarity obtained from the proposed method for the taxiway bridge was 0.996 compared with the finite element method (FEM). The maximum peak deviation rate of the transverse load distribution coefficient for the proposed method was 14.88 % and obviously lower than 34.74 % for the RJG method. For the highway bridge, the cosine similarity of the influence line derived from the proposed method was 0.995, and the maximum peak deviation rate of the transverse load distribution coefficient for the proposed method was 6.66 % and lower than 16.14 % for the RJG method. The results indicate that the proposed method can be used to calculate the transverse load distribution of wide box girder bridges accurately and efficiently.
The distribution law of shock wave pressure in typical trenches
Authors: Shang Fei , Wang Liangquan 
Published: March 2024

Trenches, as important practical military facilities, have important theoretical and military value in evaluating the damage power of ammunition, operational application, and effective safety protection of personnel on the battlefield through the spatiotemporal evolution of explosive shock waves within them. At present, there is a lack of in-depth research on the distribution and impact of overpressure inside the trench. The paper constructed a typical finite element simulation model of a trench, numerically calculated the shock wave overpressure inside the trench and on the wall, analyzed the spatiotemporal distribution of shock wave pressure in various parts of the trench, conducted on-site explosion tests, and installed shock wave pressure sensor measurement points in the trench. The pressure time history curve was obtained, and verified and compared with the simulation calculation results. Research data shows that the peak overpressure of the shock wave in the trench increases sequentially from the front wall to the back wall. The peak overpressure of the shock wave at the front wall attenuates by 10 % to 20 % compared to the inside of the trench, and increases by 40 % to 60 % at the back wall; The peak overpressure in the trench exhibits a “V-shaped” distribution at different depths, decreasing first and then increasing as the depth increases. The maximum overpressure peak increases by 40 % to 50 % compared to the minimum; Based on simulation and measured data in the trench, as well as the distribution law of shock wave pressure, safety protection suggestions for on-site combat personnel in the trench are provided.
Experiences of community-based water supply organizations partnerships in rural areas of Colombia
Authors: Blanco-Moreno Carolina , Amaya-Domínguez Jorge , Bernal-Pedraza Andrea Yolima 
Published: March 2024

Abstract
Clean water for human consumption in rural areas of Latin America and the Caribbean is usually provided by community-based water supply organizations (CBWSOs). Collaborative partnerships with community-based water supply organizations (CBWSOPs) are established to tackle technical and institutional challenges concerning safe water supply. This article analyses some features of the CBWSOs and their partnerships, based on the experience of ACUANARIÑO and ASDAL – Tres Esquinas, two CBWSOs located in Valle del Cauca – Colombia, following their participation at the local, municipal (ASOOCSAS Tuluá), subnational (Asociación de Organizaciones Comunitarias Prestadoras de Servicios Públicos de Agua y Saneamiento de Colombia (AQUACOL)), national (COCSASCOL), and transnational levels (CLOCSAS). The main findings of this work, after using a participatory approach, are that initial partnerships between CBWSOs emerge from informal agreements built on the neighbourhood logic typical of rurality; however, as moving towards higher scales, agreements become more formal to allow for dialogue and discussion with governmental organizations in the water and sanitation sector. This is also a strategy for the recognition of community water management. Thus, CBWSOPs are construed under a collaborative and non-profit approach, in the manner of water operator partnerships.
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Araghi Mahmood , Gharebakhshi Farshad , Faramarzi Fatemeh , Mafi Alireza , Mousavi Tahoora , Alimohammadi Mina , Soleimantabar Hussein 
Published: March 2024

Background:
Metastatic Triple-negative Breast Cancer (mTNBC) is the most aggressive
form of breast cancer, with a greater risk of metastasis and recurrence. Research studies have
published in-depth analyses of the advantages and disadvantages of pembrolizumab, and early data
from numerous trials suggests that patients with mTNBC have had remarkable outcomes. This
meta-analysis compares the data from numerous relevant studies in order to evaluate the safety
and efficacy of pembrolizumab monotherapy or combination therapies for mTNBC.

Methods:
To identify eligible RCTs, a thorough literature search was carried out using electronic
databases. CMA software was utilized to perform heterogeneity tests using fixed and random-effects
models.

Results:
According to our pooled data, the median Progression-free Survival (PFS) was 2.66
months, and the median overall survival (OS) was 12.26 months. Furthermore, by comparing efficacy
indicators between PD-L1–positive and PD-L1–negative groups, a correlation was found between
the overexpression of PD-L1 with OS, PFS, and ORR. Patients with PD-L1-positive tumors
had a higher response rate, with an ORR of 21.1%, compared to the patients with PD-L1-negative
tumors. The ORR for first-line immunotherapy was higher than that of ≥second-line immunotherapy.
In addition, pembrolizumab plus combination treatment resulted in a pooled incidence of immune-
related adverse events of 22.7%.

Conclusion:
A modest response to pembrolizumab monotherapy was detected in the mTNBC patients.
Furthermore, a better outcome from pembrolizumab treatment may be predicted by PD-L1--
positive status, non-liver/lung metastases, combination therapy, and first-line immunotherapy.
Pembrolizumab, in combination with chemotherapy, may be more beneficial for patients whose tumors
are PD-L1 positive.