bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undergraduate and graduate students' conceptual understanding of model classification outcomes under the lens of scientific argumentation
Authors: Wiese Lucas , Will Pinto Hector E. , Magana Alejandra J. 
Published: March 2024

AbstractRecent advancements in artificial intelligence (AI) and machine learning (ML) have driven research and development across multiple industries to meet national economic and technological demands. Consequently, companies are investing in AI, ML, and data analytics workforce development efforts to digitalize operations and enhance global competitiveness. As such, evidence‐based educational research around ML is essential to provide a foundation for the future workforce as they face complex AI challenges. This study explored students' conceptual ML understanding through a scientific argumentation framework, where we examined how they used evidence and reasoning to support claims about their ML models. This framework lets us gain insight into students' conceptualizations and helped scaffold student learning via a cognitive apprenticeship model. Thirty students in a mechanical engineering classroom at Purdue University experimented with neural network ML models within a computational notebook to create visual claims (ML models) with textual explanations of their evidence and reasoning. Accordingly, we qualitatively analyzed their learning artifacts to examine their underfit, fit, and overfit models and explanations. It was found that some students tended toward technical explanations while others used visual explanations. Students with technically dominant explanations had higher proficiency in generating correctly fit models but lacked explanatory evidence. Conversely, students with visually dominant explanations provided evidence but lacked technical reasoning and were less accurate in identifying fit models. We discuss implications for both groups of students and offer future research directions to examine how positive pedagogical elements of learning design can optimize ML educational material and AI workforce development.
Building Rapport in Interviews with Adolescent Trafficking Victims
Authors: Dianiska Rachel E. , Simpson Emma , Kim Sarah , Lyon Thomas D. , Quas Jodi A. 
Published: March 2024

AbstractThough much is known about children's sexual abuse disclosure, less attention has been directed towards disclosure in other types of youthful victims, especially those who may be reluctant to tell due to either normative development or victims' specific experiences. Trafficked youth, particularly those who are adolescents, represent one such group. Understanding how suspected youth trafficking victims are questioned by authorities, especially with respect to establishing rapport and trust, is important for informing professionals how to effectively question this unique population of victims to overcome their reluctance. We examined transcripts of interviews conducted by federal interviewers (n = 12,653 question‐answer turns across 33 interviews) and police (n = 4,972 question‐answer turns across 14 interviews) with trafficked youth between the ages of 12 and 18. Interviews were reliably coded for the length of pre‐substantive questioning, provision of instructions and ground rules, and use of rapport building and supportive strategies. Federal interviewers used pre‐substantive instructions and built rapport with potential victims more often than police did. Also, and although infrequently used overall, supportive interviewing strategies were evident more often by federal interviewers than police. Results provide much‐needed knowledge about how law enforcement investigators interview and elicit disclosures from vulnerable populations of adolescent victims.
POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression
Authors: Monno Masayoshi , Ogiri Masayo , Seishima Ryo , Suzuki Yoshiyuki , Hattori Kaoru , Matsui Shimpei , Shigeta Kohei , Okabayashi Koji , Kitagawa Yuko 
Published: March 2024

AbstractColorectal mucinous adenocarcinoma (MAC) is one of the most lethal histological types of colorectal cancer, and its mechanism of development is not well understood. In this study, we aimed to clarify the molecular characteristics of MAC via in silico analysis using The Cancer Genome Atlas database. The expression of genes on chromosome 20q (Chr20q) was negatively associated with the expression of MUC2, which is a key molecule that can be used to distinguish between MAC and nonmucinous adenocarcinoma (NMAC). This was consistent with a significant difference in copy number alteration of Chr20q between the two histological types. We further identified 475 differentially expressed genes (DEGs) between MAC and NMAC, and some of the Chr20q genes among the DEGs are considered to be pivotal genes used to define MAC. Both in vitro and in vivo analysis showed that simultaneous knockdown of POFUT1 and PLAGL2, both of which are located on Chr20q, promoted MUC2 expression. Moreover, these genes were highly expressed in NMAC but not in MAC according to the results of immunohistological studies using human samples. In conclusion, POFUT1 and PLAGL2 are considered to be important for defining MAC, and these genes are associated with MUC2 expression.
Silver nanoparticles stimulate 5‐Fluorouracil‐induced colorectal cancer cells to kill through the upregulation TRPV1‐mediated calcium signaling pathways
Authors: Kaya Müge Mavioğlu 
Published: March 2024

AbstractThe involvement of the TRP vanilloid 1 (TRPV1) cation channel on the 5‐Fluorouracil (5‐FU)‐caused Ca2+ signals through the activation of the apoptotic signaling pathway and stimulating the mitochondrial Ca2+ and Zn2+ accumulation‐induced reactive oxygen species (ROS) productions in several cancer cells, except the colorectal cancer (HT‐29) cell line, was recently reported. I aimed to investigate the action of silver nanoparticles (SiNPs) and 5‐FU incubations through the activation of TRPV1 on ROS, apoptosis, and cell death in the HT‐29 cell line. The cells were divided into four groups: control, SiNP (100 µM for 48 h), 5‐FU (25 μM for 24 h), and 5‐FU + SiNP. SiNP treatment through TRPV1 activation (via capsaicin) stimulated the oxidant and apoptotic actions of 5‐FU in the cells, whereas they were diminished in the cells by the TRPV1 antagonist (capsazepine) treatment. The apoptotic and cell death actions of 5‐FU were determined by increasing the propidium iodide/Hoechst rate, caspase‐3, ‐8, and ‐9 activations, mitochondrial membrane depolarization, lipid peroxidation, and ROS, but decreasing the glutathione and glutathione peroxidase. The increase of cytosolic free Ca2+ and Zn2+ into mitochondria via the stimulation of TRPV1 current density increased oxidant and apoptotic properties of 5‐FU in the cells. For the therapy of HT‐29 tumor cells, I found that the combination of SiNPs and 5‐FU was synergistic via TRPV1 activation.
Fibroblast activation protein promotes progression of hepatocellular carcinoma via regulating the immunity
Authors: Wang Xiangcheng , Niu Ruilong , Yang Hao , Lin Yu , Hou Hui , Yang Hong 
Published: March 2024

AbstractFibroblast activation protein (FAP) has been indicated to express in cancer‐associated fibroblasts (CAFs) in most cancers. This work was dedicated to exploring FAP's effects on hepatocellular carcinoma (HCC). The data were extracted from The Cancer Genome Atlas, Gene Expression Omnibus, ImmPort, and Reactome databases. The correlation between FAP and HCC patients' prognosis was explored via survival analysis. The qRT‐PCR and western blot analysis were used to analyze the FAP mRNA and protein expression levels, respectively. The cell proliferation and apoptosis were determined using the cell counting kit‐8 assay kit and Annexin V‐FITC/PI apoptosis kit, respectively. The HCC patients with FAP overexpression displayed a worse prognosis. The FAP expression was positively associated with the infiltration levels of tumor purity, B cell, CD8 + T cell, CD4 + T cell, macrophage, neutrophil, and dendritic cell. The optimal nine immune related genes were screened between two groups (FAP high vs. low). Moreover, we identified 24 energy metabolism related genes (FAP high vs. low) and these 24 genes were highly expressed in the high FAP expression group. The FAP expression had a significant positive correlation with the expression of PD‐1, CTLA4, PDL‐1, and PDL‐2. The FAP overexpression promoted proliferation and migration while inhibiting the apoptosis of HCC cells. The FAP overexpression promoted the progression of HCC by regulating the immunity to affect the prognosis of HCC patients, thereby serving as a poor prognostic marker for HCC patients.
Exploring the best strategy for true bifurcation coronary diseases to avoid a “fall between two stools”
Authors: Suzuki Nobuaki 
Published: March 2024

Key points
The double kissing crush technique is a promising strategy for true bifurcation coronary diseases, although it is yet to be recognized as a “gold standard” because of its complexity.
A “one strategy fits all” approach is not applicable to bifurcation percutaneous coronary intervention (PCI) because of diversity.
New technologies may overcome this issue with diversity and support tailored PCI for true bifurcation coronary diseases.
Interfacial Bonding Induced Charge Transfer in Two‐Dimensional Amorphous MoO3‐x/Graphdiyne Oxide Non‐Van der Waals Heterostructures for Dominant SERS Enhancement
Authors: Yang Jian , Yan Pengfei , Chen Zongwei , Liu Wei , Liu Zhaoxi , Ma Zijian , Xu Qun 
Published: March 2024

AbstractTwo‐dimensional semiconductor‐based nanomaterials have shown to be an effective substrate for Surface‐enhanced Raman Scattering (SERS) spectroscopy. However, the enhancement factor (EF) tends to be relatively weak compared to that of noble metals and does not allow for trace detection of molecules. In this work, we report the successful preparation of two‐dimensional (2D) amorphous non‐van der Waals heterostructures MoO3‐x/GDYO nanomaterials using supercritical CO2. Due to the synergistic effect of the localized surface plasmon resonance (LSPR) effect and the charge transfer effect, it exhibits excellent SERS performance in the detection of methylene blue (MB) molecules, with a detection limit as low as 10−14 M while the enhancement factor (EF) can reach an impressive 2.55×1011. More importantly, the chemical bond bridging at the MoO3‐x/GDYO heterostructures interface can accelerate the electron transfer between the interfaces, and the large number of defective surface structures on the heterostructures surface facilitates the chemisorption of MB molecules. And the charge recombination lifetime can be proved by a ~1.7‐fold increase during their interfacial electron‐transfer process for MoO3‐x/GDYO@MB mixture, achieving highly sensitive SERS detection.
The Application of Porous Organic Polymers as Metal Free Photocatalysts in Organic Synthesis
Authors: Debruyne Maarten , Van Der Voort Pascal , Van Speybroeck Veronique , Stevens Christian V. 
Published: March 2024

AbstractConcerns about increasing greenhouse gas emissions and their effect on our environment highlight the urgent need for new sustainable technologies. Visible light photocatalysis allows the clean and selective generation of reactive intermediates under mild conditions. The more widespread adoption of the current generation of photocatalysts, particularly those using precious metals, is hampered by drawbacks such as their cost, toxicity, difficult separation, and limited recyclability. This is driving the search for alternatives, such as porous organic polymers (POPs). This new class of materials is made entirely from organic building blocks, can possess high surface area and stability, and has a controllable composition and functionality. This review focuses on the application of POPs as photocatalysts in organic synthesis. For each reaction type, a representative material is discussed, with special attention to the mechanism of the reaction. Additionally, an overview is given, comparing POPs with other classes of photocatalysts, and critical conclusions and future perspectives are provided on this important field.
Room Temperature Phosphorescence in Crystalline Iodinated Eumelanin Monomer
Authors: Vinod Kavya , Jadhav Sohan D. , Hariharan Mahesh 
Published: March 2024

AbstractWe report the room temperature phosphorescence upon iodination on a crystalline eumelanin monomer with shielded hydroxyl moieties, ethyl 5,6‐dimethoxyindole‐2‐carboxylate (DMICE). Ultrafast intersystem crossing (ISC) is observed in the iodinated (IDMICE) as well as brominated (BDMICE) analogues of the eumelanin monomer derivative in solution. The triplet quantum yields (φT) and intersystem crossing rates (kISC) of the halogenated eumelanin derivatives are
=25.4±1.1 %;
=1.95×109 s−1 and
=59.1±1.6 %;
1.36×1010 s−1, as monitored using transient absorption spectroscopy. Theoretical calculations based on nuclear ensemble method reveal that computed kISC and spin‐orbit coupling matrix elements for eumelanin derivatives are larger for IDMICE relative to BDMICE. The halogen and π‐π interactions, with distinct excitonic coupling and higher ISC rate promote phosphorescence in IDMICE molecular crystals. Accessing triplet excited states and resultant photoluminescence through structural modification of eumelanin scaffolds paves way for exploring the versatility of eumelanin‐inspired molecules as bio‐functional materials.
Achieving Dendrite‐Free Zinc Metal Anodes via Molecule Anchoring and lon‐Transport Pumping
Authors: He Zhongqian , Yu Huaming , Chen Dongping , Ni Xuyan , Yan Chunshuang , Lv Chade , Chen Yuejiao 
Published: March 2024

AbstractThe potential for scale‐up application has been acknowledged by researchers for rechargeable aqueous zinc‐ion batteries (ZIBs). Nonetheless, the progress of the development is significantly impeded due to the instability of the interface between the zinc anode and electrolyte. Herein, efficient and environmentally benign valine (Val) were introduced as aqueous electrolyte additive to stabilize the electrode/electrolyte interface (EEI) via functional groups in additive molecules, thus achieving reversible dendrite‐free zinc anode. The amino groups present in Val molecules have a strong ability to adsorb on the surface of zinc metal, enabling the construction of anchored molecular layer on the surface of zinc anodes. The strongly polar carboxyl groups in Val molecules can act as ion‐transport pumps to capture zinc ions in the electric double layer (EDL) through coordination chemistry. Therefore, this reconstructed EEI could modulate the zinc ion flux and simultaneously suppress side reactions and dendritic growth of Zn. Consequently, a long stable cycling up to 1400 h at a high current density of 20 mA cm−2 is achieved. Additionally, Zn//V2O5 full cell with Val additive exhibit enhanced cyclability, retaining 77 % capacity after 3000 cycles, displaying significant potential in promoting the commercialization of ZIBs.
Genetically Fusing Order‐Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials
Authors: Patkar Sai S. , Wang Bin , Mosquera Ana Maria , Kiick Kristi L. 
Published: March 2024

AbstractThe unique biophysical and biochemical properties of intrinsically disordered proteins (IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) offer opportunities for producing multistimuli‐responsive materials; their sequence‐encoded disorder and tendency for phase separation facilitate the development of multifunctional materials. This review highlights the strategies for enhancing the structural diversity of elastin‐like polypeptides (ELPs) and resilin‐like polypeptides (RLPs), and their self‐assembled structures via genetic fusion to ordered motifs such as helical or beta sheet domains. In particular, this review describes approaches that harness the synergistic interplay between order‐promoting and thermoresponsive building blocks to design hybrid biomaterials, resulting in well‐structured, stimuli‐responsive supramolecular materials ordered on the nanoscale.
Study of color degradation in package prints: Analyzing kinetics with principal component analysis
Authors: Das Anirban , Mandal Mahasweta 
Published: March 2024

AbstractColor degradation is a pressing issue in various fields like food and medicine packaging, as well as printed materials, leading to a loss or distortion of vital information. Therefore, understanding how the color of package prints evolves over time is essential for product quality assessment and effective product life cycle management. This study focuses on investigating color changes in prints on blister foils, widely used in the medicine and packaging industries. To assess fading characteristics, samples printed via the gravure process have been exposed to a Xenon Test Chamber (B‐SUN). Spectrophotometric measurements of the prints have been conducted using a spectroradiometer, and the data have been analyzed using principal component analysis (PCA). The fading nature of cyan and black prints aligns with Type IV, while magenta and yellow prints correspond to Type II, as described by Giles. Notably, cyan and black inks demonstrated resistance toward fading at the end of the exposure, with a minor exception. The investigation involved curve fitting, revealing a consistent first‐order kinetic model governing fading rates throughout the exposure time. High R2 values (0.96–0.99) and low root means square error values (0.02–0.08) are observed across all cases. While color fading involves diverse kinetics, the fading rate consistently adheres to a singular first‐order kinetic path. The study highlights that yellow ink is most sensitive to light, followed by magenta ink. These findings offer valuable insights for optimizing packaging materials and ensuring product quality in industries reliant on printed materials. By mitigating color degradation, manufacturers can enhance the longevity and appeal of their products, reinforcing consumer trust and satisfaction. Furthermore, the effective utilization of PCA as a data analysis tool offers a valuable approach for future investigations in color science and related fields.
Highly Specific Sulfadiazine Detection Using a Two‐Dimensional Europium‐Organic Coordination Polymer
Authors: Min Hui , Zhu Zhuo‐hang , Min Yu‐jiao , Yao Binling , Cheng Peng 
Published: March 2024

AbstractSulfadiazine (SFZ) is an inexpensive large‐consumption antibiotic used for treat bacterial infections but an excess of residues in food can be harmful. Fast and specific luminescence detection of SFZ is highly challenging because of the interference of structurally similar antibiotics. In this work, we develop a two‐dimensional europium‐organic coordination polymer with excellent luminescence and water stability for highly specific detection of SFZ in the range of 0–0.2 mM. Structural analysis shows that the high stability of coordination polymer is due to the high coordination number of europium ion and the special chelating coordination structure of ligand. The experiment results revealed that the high selectivity and effectively luminescence quenched behaviour of coordination polymer toward SFZ is caused by highly efficient inner filter effect.
Can heterogeneous media attention invigorate green technological innovation: A moderating role of chief executive officer narcissism
Authors: Yang Hailan , Shi Xiangjiao , Shah Syed Ghulam Meran 
Published: March 2024

AbstractThe current study contemplates the mechanism of heterogeneous media attention affecting green technological innovation (GTI) amid moderation of chief executive officer (CEO) narcissism. Based on the accumulated data of 1545 listed Chinese firms over the period from 2014 to 2018, we have demonstrated that media attention imposes a significant positive effect on GTI; the negative coverage is greater than positive media coverage in effecting GTI whereas CEO narcissism positively moderates the effect of media attention on GTI. The results also show the regional media coverage is greater than national media coverage in effecting GTI, while the CEO narcissism more strongly moderates the effect of negative coverage on GTI and the effect of regional media coverage on GTI. This study provides new insights into the existing literature by deconstructing media attention and enriches the studies in the context of media attention‐GTI relationship from a point of view of the particular personality trait of a CEO.
Quantifying the probability of a successful marine bioinvasion due to source‐destination risk factors
Authors: Tzeng Mimi W. , Floerl Lisa , Schattschneider Jessica , Floerl Oliver , Jeffs Andrew , Zaiko Anastasija 
Published: March 2024

AbstractThe increasing spread of marine non‐indigenous species (NIS) due to the growth in global shipping traffic is causing widespread concern for the ecological and economic impacts of marine bioinvasions. Risk management authorities need tools to identify pathways and source regions of priority concern to better target efforts for preventing NIS introduction. The probability of a successful NIS introduction is affected by the likelihood that a marine species entrained in a transport vector will survive the voyage between origin and destination locations and establish an independently reproducing population at the destination. Three important risk factors are voyage duration, range of environmental conditions encountered during transit and environmental similarity between origin and destination. In this study, we aimed for a globally comprehensive approach to assembling quantifications of source‐destination risk factors from every potential origin to every potential destination. To derive estimates of voyage‐related marine biosecurity risk, we used computer‐simulated vessel paths between pairs of ecoprovinces in the Marine Ecoregions Of the World biogeographic classification system. We used the physical length of each path to calculate voyage duration risk and the cross‐latitudinal extent of the path to calculate voyage path risk. Environmental similarity risk was based on comparing annual average sea surface temperature and salinity within each ecoprovince to those of other ecoprovinces. We derived three separate sets of risk quantifications, one each for voyage duration, voyage path and environmental similarity. Our quantifications can be applied to studies that require source‐destination risk estimates. They can be used separately or combined, depending on the importance of the types of source‐destination risks that might be relevant to particular scientific or risk management questions or applications.