bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectroscopy of planetary mass brown dwarfs in Orion
Authors: Lucas P. W. , Weights D. J. , Roche P. F. , Riddick F. C. 
Published: October 2006

Abstract
We report the results of near infrared spectroscopy of 11 luminosity-selected candidate planetary mass objects (PMOs) in the Trapezium Cluster with Gemini South/Gemini Near-Infrared Spectrograph and Gemini North/Near-Infrared Imager. Six have spectral types ⩾M9, in agreement with expectations for PMOs. Two have slightly earlier types, and three are much earlier types which are probably field stars. Four of the six sources with types ⩾M9 have pseudo-continuum profiles which confirm them as low gravity cluster members. The gravity status of the other cool dwarfs is less clear but these remain candidate PMOs. The derived number fraction of PMOs with M = 3 – 15 MJup is 1–14 per cent, these broad limits reflecting the uncertainty in source ages. However, the number fraction with M &lt; 20 MJup is at least 5 per cent. These detections add significantly to the body of evidence that a planetary mass population is produced by the star formation process.
Influence of Patterns of Hormone Replacement Therapy Use and Mammographic Density on Breast Cancer Detection
Authors: Chiarelli Anna M. , Kirsh Victoria A. , Klar Neil S. , Shumak Rene , Jong Roberta , Fishell Eve , Yaffe Martin J. , Boyd Norman F. 
Published: October 2006

Abstract
Background: There is evidence that factors such as current hormone replacement therapy (HRT) use and mammographic density may each lower the sensitivity of mammography and are associated with a greater risk of developing an interval cancer. This study explores this relationship further by examining the influence of patterns of HRT use and the percentage of mammographic density on the detection of breast cancer by classification of interval cancer.
Methods: This study uses a case-case design nested within a cohort of women screened by the Ontario Breast Screening Program between 1994 and 2002. Interval cancers, both those missed at screening but seen on retrospective review (n = 87) or true intervals without visible tumor signs at screening (n = 288) were matched to 450 screen-detected cancers. The association between the percentage of mammographic density, measured by radiologists and a computer-assisted method, and HRT use, ascertained from a mailed questionnaire, and the risk of being diagnosed with an interval cancer was estimated using conditional logistic regression.
Results: A monotonic gradient of increasing risk for interval cancers was found for each 25% increase in mammographic density [odds ratio (OR), 1.77; 95% confidence intervals (95% CI), 1.07-2.95 for missed intervals and OR, 2.16; 95% CI, 1.59-2.94 for true intervals]. After adjusting for mammographic density, a significantly increased risk for true-interval cancers remained for women taking estrogen alone (OR, 1.75; 95% CI, 1.11-2.83) as well as for missed- (OR, 2.84; 95% CI, 1.32-6.13) and true-interval cancers (OR, 1.79; 95% CI, 1.10-2.90) for women taking combined HRT.
Conclusions: Information on mammographic density and HRT use should routinely be collected at the time of screening. Women at risk should be made aware of the lower sensitivity of mammography and offered alternative procedures for screening. (Cancer Epidemiol Biomarkers Prev 2006;15(10):1856–63)
Influences of Chymase and Angiotensin I-Converting Enzyme Gene Polymorphisms on Gastric Cancer Risks in Japan
Authors: Sugimoto Mitsushige , Furuta Takahisa , Shirai Naohito , Ikuma Mutsuhiro , Sugimura Haruhiko , Hishida Akira 
Published: October 2006

Abstract
Backgrounds and Aims: The renin-angiotensin system plays an important role in homeostasis. Angiotensin II, which is generated by chymase and angiotensin I-converting enzyme (ACE), controls blood pressure as well as angiogenesis and cell proliferation. The aim of this study was to clarify the association of the chymase gene (CMA/B) and ACE polymorphisms with susceptibility to gastric cancer and peptic ulcer.
Methods: We assessed CMA/B A/G and ACE insertion/deletion (I/D) polymorphisms in H. pylori-positive gastric cancers (n = 119), gastric ulcers (n = 127), and duodenal ulcers (n = 105), and controls (n = 294) consisting of H. pylori-positive gastritis alone (n = 162) and H. pylori-negative subjects (n = 132) by PCR methods.
Results: In CMA/B polymorphism, the age- and sex-adjusted odds ratios (OR) of A/A and A/G genotypes relative to the G/G genotype for gastric cancer risk were 7.115 (95% confidence interval, 1.818-27.845) and 1.956 (95% confidence interval, 1.137-3.366), respectively. There was an increased risk for gastric ulcer in the A/A genotype (OR, 3.450; 1.086-10.960). However, there was no association between ACE polymorphism and susceptibility to gastric cancer and peptic ulcer. In allele combination analysis of CMA/B and ACE polymorphisms, the A/I allele combinations (CMA/B G/A or A/A and ACE I/I genotype) significantly increased the risk of gastric cancer development (OR, 4.749, 2.050-11.001) compared with the G/I allele combinations (CMA/B G/G and ACE I/I genotype).
Conclusions: The CMA/B polymorphism was associated with an increased risk for gastric cancer and gastric ulcer development. The genotyping test of the renin-angiotensin system could be useful for the screening of individuals with higher risks of gastric cancer and gastric ulcer. (Cancer Epidemiol Biomarkers Prev 2006;15(10):1929–34)
The Enigmatic Epidemiology of Nasopharyngeal Carcinoma
Authors: Chang Ellen T. , Adami Hans-Olov 
Published: October 2006

AbstractNasopharyngeal carcinoma (NPC) has a unique and complex etiology that is not completely understood. Although NPC is rare in most populations, it is a leading form of cancer in a few well-defined populations, including natives of southern China, Southeast Asia, the Arctic, and the Middle East/North Africa. The distinctive racial/ethnic and geographic distribution of NPC worldwide suggests that both environmental factors and genetic traits contribute to its development. This review aims to summarize the current knowledge regarding the epidemiology of NPC and to propose new avenues of research that could help illuminate the causes and ultimately the prevention of this remarkable disease. Well-established risk factors for NPC include elevated antibody titers against the Epstein-Barr virus, consumption of salt-preserved fish, a family history of NPC, and certain human leukocyte antigen class I genotypes. Consumption of other preserved foods, tobacco smoking, and a history of chronic respiratory tract conditions may be associated with elevated NPC risk, whereas consumption of fresh fruits and vegetables and other human leukocyte antigen genotypes may be associated with decreased risk. Evidence for a causal role of various inhalants, herbal medicines, and occupational exposures is inconsistent. Other than dietary modification, no concrete preventive measures for NPC exist. Given the unresolved gaps in understanding of NPC, there is a clear need for large-scale, population-based molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease. (Cancer Epidemiol Biomarkers Prev 2006;15(10):1765–77)
Sexual imprinting on a novel blue ornament in zebra finches
Authors: Caspers Barbara , Witte Klaudia 
Published: October 2006

AbstractSexual imprinting plays an important role for the development of mate preferences in birds. We tested whether male and female zebra finches Taeniopygia guttata sexually imprinted on an evolutionary novel trait, a blue feather on the forehead in parents. Additionally, we tested whether males and females would transfer a learned preference for the blue feather to a preference for blue leg bands, and whether a potential mate with two novel blue traits can amplify its attractiveness. Offspring were raised by parents in four different imprinting groups: (1) both parents unadorned; (2) the mother adorned only; (3) the father adorned only; (4) both parents adorned with the blue feather. After young reached maturity, we tested their mate preference for adorned and unadorned conspecifics of the opposite sex in binary choice tests. Females of the father adorned imprinting group sexually imprinted on the blue feather, and females reared by adorned parents showed a tendency to prefer adorned males. None of the males sexually imprinted on the blue feather. Our study replicates the results of a previous study on sexual imprinting on a red feather in zebra finches. We, therefore, propose a sex difference in the learning process of sexual imprinting. Females sexually imprinted on the blue feather did not transfer the learned preference to males with blue leg bands, and two novel blue traits could not amplify the attractiveness in males and females for the opposite sex. Our study emphasizes the role of sexual imprinting for the cultural evolution in mate preferences in zebra finches.
Cyberorganizing United States Constituencies for Africa
Authors: Humphries Jill 
Published: October 2006

AbstractThis case study examines how state level constituencies for Africa used advanced communication technology to organize and mobilize state delegations to the National Summit on Africa with the intent of effecting United States foreign policy toward Africa. More specifically, it focuses on the application of information communication technology (ICT) usage as a communication and coordination tool by the National Summit Secretariat. Secondly, it examines the extent to which state delegations used advanced communication technology to complete the relevant task of developing a national policy planof-action. I hypothesize that ICTs might assist the National Summit by reducing costs of attracting and maintaining membership and facilitating coordination and communication both horizontally (among membership) and vertically (to policymakers). Primary data collection methods included administering a survey to state chairs, conducting semi-structured interviews, and reviewing state web-pages and e-groups. Preliminary results indicate that information technology to some extent can reduce coordination problems and barriers to participation; however, other factors, such as computer literacy, access to computers, and the ability to use alternative institutional resources, mediate the effectiveness of information technology usage. Implications for implementing information technology as a more effective tool for collective organizing are explored.
On the Brain Drain of Africans to America: Some Methodological Observations
Authors: Dodoo F. Nii-Amoo , Takyi Baffour , Mann Jesse 
Published: October 2006

AbstractRecurring debates about the impact of the brain drain— the developing world's loss of human capital to more developed countries—has motivated estimation of the magnitude of the phenomenon, most recently by the World Bank. Although frequently cited as a key contributor to Africa's wanting development record, what constitutes the "brain-drain" is not always clearly defined. Today, in the absence of an accounting system, resolution of the definitional and measurement question depends on relative comparisons of measurement variants, which will identify definitional shortcomings by clarifying the merits and demerits of these variants, and thereby suggest corrective imputations. This paper compares the World Bank's approach to a chronological precedent (Dodoo 1997) to clarify the value of variant comparisons. The resultant implications for corrections are also discussed.
Pancha Kanya
Authors: Bhattacharya Pradip 
Published: October 2006

At times we come across traditional sayings that pose enigmas. Often, striving to resolve the puzzle turns into a quest, a search for meaning that, quite unexpectedly, throws light on problems facing us today. Such an enigmatic Sanskrit couplet exhorts invoking five females regularly to redeem us of failings, howsoever grievous: Ahalya draupadi kunti tara mandodari tatha\ Panchakanya smarenityam mahapataka nashinim\\ The choice of the five is itself intriguing, all being epic heroines: Ahalya, Tara and Mandodari from the Ramayana; Kunti and Draupadi from the Mahabharata. Even more so is the celeberation of each as kanya, not as nari (woman) or sati (devoted to the husband). If kanya connotes ‘virgin’ (‘daughter’ makes no sense as several of them are not womb-born), the matter becomes more puzzling since each had intimate relationships with more than one man. In analysing what is known about them, we are surprised, fore these heroines of ancient myth turn out to be, quite unexpectedly, guides for us in the twenty-first century. In the previous issue (12:1) the exploration had dealt with four of the five kanyas. This concluding part examines the persona of Draupadi, heroine of the world's longest epic, the Mahabharata.1
Mobility among young urban dwellers
Authors: Jensen Mette 
Published: October 2006

Young people of today travel and are more mobile than ever before. They have a considerable appetite for travelling and practically unlimited opportunities for mobility. Not only physical/bodily travelling, but also virtual travels via the Internet, or communicative travels via email, (mobile) phones and so on are separately and in combination a marked feature in everyday life among young people (see Tully,2002).To today's youth, mobility is a fact of life that they embrace with enthusiasm and, in a number of ways, mobility sets the agenda for and constantly transforms their social life.It influences their way of perceiving and understanding the world, which in turn makes them demand a still more and increasingly complex mobility. The present article is based on a study of the meaning of mobility in modern everyday life (Jensen, 2001),1 and focus will be on mobility among young people in big cities.
Taking the right to exit seriously
Authors: Spiecker Ben , De Ruyter Doret , Steutel Jan 
Published: October 2006

Both diversity and autonomy liberals agree that adults have the right to exit from voluntary associations. As children do not have this right, the paradoxical character of the upbringing of children in fundamentalist and ultra-orthodox communities is evident. Diversity liberals like Galston and Spinner-Halev seem to take an ambivalent position with regard to the right to exit, because they want to defend both the child’s future right to exit, which requires particular capacities, as well as the parental right to upbringing according to their conception of the good even if this undermines the required capacities. We defend that people need to be at least autarchic, that is self-determining and morally accountable, in order to be able to exercise their right to exit. Since this right is a civic freedom right, the state has the right and duty to ensure that children will be able to develop into autarchic persons. Therefore, our claim is that school education should aim for minimal autonomy and that such education should be compulsory. We argue that this will not undermine legitimate diversity and therefore that Galston and Spinner-Halev should be able to take an unequivocal position.
PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells
Authors: Sharkey Janelle , Khong Tiffany , Spencer Andrew 
Published: October 2006

AbstractThe effect and mode of action of the protein kinase C (PKC) inhibitor PKC412 on human multiple myeloma (MM) cell lines (HMCLs) and primary MM cells was explored. We found that PKC412 induced apoptosis of HMCLs and primary MM cells with variable efficacy; however, some activity was seen against all HMCLs and primary MM cells with at least 0.5 μM PKC412. PARP cleavage and decreased PKC activity was observed in all HMCLs tested. Furthermore, PKC412 inhibited C-FOS transcription and nuclear protein expression, induced reactive oxygen species (ROS) production, and induced both sustained C-JUN expression and phosphorylation. The latter was inhibited by cotreatment with the JNK inhibitor SP600125, which similarly abrogated PKC412-induced apoptosis, suggesting that PKC412-induced apoptosis is a JNK-dependent event. PKC412 treatment secondarily induced prosurvival stress responses as evidenced by activation of NFκB and increased expression of the heat shock proteins HSP70 and HSP90. Consistent with the former, sequential inhibition of NFκB activation with bortezomib or SN50 synergistically enhanced cell killing. Our results demonstrate that PKC412 induces JNK-dependent apoptosis of HMCLs and primary MM cells and that this effect is enhanced by NFκB inhibition. The further evaluation of PKC412 in the treatment of MM is justified.
Host-virus interaction: a new role for microRNAs
Authors: Scaria Vinod , Hariharan Manoj , Maiti Souvik , Pillai Beena , Brahmachari Samir K 
Published: October 2006

Abstract
MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play critical roles in a wide spectrum of biological processes. Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host-pathogen interaction networks. Evidence suggests that both virus and hosts encode microRNAs. The exclusive dependence of viruses on the host cellular machinery for their propagation and survival also make them highly susceptible to the vagaries of the cellular environment like small RNA mediated interference. It also gives the virus an opportunity to fight and/or modulate the host to suite its needs. Thus the range of interactions possible through miRNA-mRNA cross-talk at the host-pathogen interface is large. These interactions can be further fine-tuned in the host by changes in gene expression, mutations and polymorphisms. In the pathogen, the high rate of mutations adds to the complexity of the interaction network. Though evidence regarding microRNA mediated cross-talk in viral infections is just emerging, it offers an immense opportunity not only to understand the intricacies of host-pathogen interactions, and possible explanations to viral tropism, latency and oncogenesis, but also to develop novel biomarkers and therapeutics.
Dysphonia in the aging: Physiology versus disease
Authors: Woo Peak , Casper Janina , Colton Raymond , Brewer David 
Published: October 2006

AbstractA chart review from 151 dysphonic patients over the age of 60 was done to define aging related voice disorders. Overwhelmingly, patients suffered from dysphonia due to disease processes associated with aging rather than to physiologic aging alone. These include: 1. central neurological disorders affecting laryngeal function (e.g., stroke, Parkinson's disease, essential tremor, Alzheimer's disease); 2. benign vocal fold lesions (e.g., Reinke's edema, benign and dysplastic epithelial lesions); 3. inflammatory disorders (e.g., laryngitis sicca, medication effect); 4. laryngeal neoplasia; and 5. laryngeal paralysis. Typical laryngeal findings of vocal fold bowing and breathiness consistent with presbylarynges were present in only six patients. Presbylarynges is not a common disorder and should be a diagnosis of exclusion made only after careful medical and speech evaluation.
Compound action potentials recorded from the exposed eighth nerve in patients with intractable tinnitus
Authors: Møller Aage R. , Møller Margareta B. , Jannetta Peter J. , Jho Hae Dong 
Published: October 2006

AbstractCompound action potentials (CAP) were recorded directly from the exposed intracranial portion of the eighth nerve in 19 patients undergoing microvascular decompression (MVD) of the eighth nerve for intractable tinnitus. The waveform of the CAPs recorded in patients with tinnitus varied from normal to highly abnormal, but only in 1 patient were there distinct abnormalities in the waveform of the CAP that could not be attributed to the patient's hearing loss. The mean values of the latencies of the N1 and N2 peaks in the CAPs recorded from the exposed eighth nerve in patients with tinnitus and high‐frequency hearing loss were virtually indistinguishable from the latencies obtained in patients with similar hearing loss but no tinnitus. There was no statistically significant difference between the latency of peak III in the brainstem auditory evoked potentials (BAEPs) in these two groups of patients, but the latency of peak V was slightly shorter (statistically significant) in the patients with tinnitus than it was in the patients without tinnitus.
Functional endonasal sinus surgery in adults and children
Authors: Lazar Rande H. , Younis Ramzi T. , Long Thomas E. 
Published: October 2006

AbstractFunctional endonasal sinus surgery (FESS) is becoming the procedure of choice for the surgical treatment of chronic and recurrent sinusitis in adults and children. Retrospective analysis of the charts of 513 adult and 260 pediatric patients who underwent FESS after failing to respond to optimal medical treatment revealed an improvement rate of approximately 80% for both age groups. Although high response rates and low complication rates were found for both groups, there were significant differences in indications, preoperative evaluation, operative technique, and methods of postoperative follow‐up for children.
Oncogenes in head and neck cancer
Authors: Irish Jonathan C. , Bernstein Alan 
Published: October 2006

AbstractPrimary head and neck squamous cell carcinomas from 58 patients were analyzed for the presence of alterations in the K‐ras, raf, and erb‐B oncogenes. Analysis of 17 fresh tumor specimens using sequence analysis of target sequences amplified by the polymerase chain reaction showed no evidence of mutations in the K‐ras oncogene. Thirty fresh tumor specimens were analyzed for the presence of raf gene activation using Southern blot analysis. Under these conditions, no mutations in the c‐raf oncogene were detected.In this study, 6 (13%) of the 47 tumors studied displayed epidermal growth factor receptor (EGFR) gene amplification and/or gene rearrangement. Overexpression of the erb‐B gene was observed in 18 (67%) of the 27 head and neck tumors studied. Those patients expressing high levels of EGFR or showing EGFR amplification had tumors that were clinically more advanced.These data suggest that amplification and over‐expression of the EGFR gene may be a useful diagnostic and prognostic marker in head and neck squamous cell carcinomas.
Bony dehiscence between singular canal and round window niche
Authors: Sato Hiroaki , Takahashi Haruo , Sando Isamu 
Published: October 2006

AbstractThe incidence of bony dehiscence of the human singular canal was studied by examining 409 human temporal bones obtained from 300 individuals. Such a dehiscence was noted in three (0.7%) of the bones from three (1%) of the individuals, all male, aged 2, 6, and 76 years. All of these bony dehiscences were located between the round window niche and the cribrose area of the singular canal. The finding of a microfissure in the vicinity of the bony dehiscence in two of the three cases indicates that such dehiscences occur independently of microfissures. Although the incidence of bony dehiscences of the singular canal is small, these dehiscences appear to have considerable clinical significance in that they form a communication between the middle and inner ears or possibly between the middle ear and the cerebrospinal fluid space.