bluuebunny/crossref_metadata_2025_split huggingface dataset:
Content of Sodium, Potassium, Calcium, Magnesium in Organism of Larva of Sibling Species <i>Сhironomus balatonicus</i> and <i>Сhironomus plumosus</i> in Dependence on Salinity<sup>1</sup>
Authors: Martemyanov V. I. , Markiyanova M. F. 
Published: April 2024

The tolerant salinity ranges are 0.008–6 and 0.09–9.3 g/L, respectively, for Ch. plumosus L., 1758 and Ch. balatonicus Devai, Wülker et Scholl, 1983. In the tolerant range of salinity, the level of sodium, potassium, calcium, magnesium in the body of Ch. balatonicus was regulated within 33.9–77.1, 7.7–13.7, 11.9–37.6, 54.7–110.6 mmol/kg wet weight, respectively. The concentration of sodium, potassium, calcium, magnesium in the body of Ch. plumosus was maintained within of 62.7–80.8, 10.6–18, 6.7–12, 2.9–6 mmol/kg wet weight in stage III larvae and 49.6–62.3, 9.7–14.8, 42.5–62.2, 47.9–83.4 mmol/kg wet weight in individuals of IV age. In the optimal salinity range of 0.8–5.3 g/L, the sodium concentration in the body of Ch. balato-nicus was maintained at a constant level, decreased in the critically low zone of 0.8–0.09 g/L, and increased in the critically high zone of 5.3–9.3 g/L. In the critically low and high salinity zone, the organism’s ability to survive is reduced. The content of sodium in the body of freshwater aquatic organisms serves as a reliable criterion for assessing the optimal, critically low and high salinity zones.
Composition and Content of Carotenoids of Gastropod <i>Tritia reticulata</i> in Black Sea
Authors: Borodina A. V. , Zadorozhny P. A. 
Published: April 2024

The results of a two–year study of the composition and content of carotenoids of sea snails Tritia reticulata (L., 1758), living in a mixed bottom community of bivalve mollusks in the sandy zone of the upper sublitoral (depth 0–1 m) of the Cossack Bay of Sevastopol, are presented. The highest content of total carotenoids was detected in June (1.8–2.09 mg/100 g of crude mass), the average Cossack Baymples for both years was 1.54 mg/100 g of crude mass. In the qualitative composition of T. reticulata taken from the pastures of bivalves on sandy-silt soil, 15 free carotenoids were identified: b-carotene, echinenone, hydroxyechinenone, astaxanthin, didehydroastaxanthin, diadinoxanthin, diatoxanthin, fucoxanthin, halocintiaxanthin, fucoxanthinol, mactraxanthin, heteroxanthin, lutein, zeaxanthin, alloxanthin and esters of the last 4 carotenoids. The po-ssibility of metabolic transformations of carotenoids is discussed.
RETURN OF DEVELOPMENT: A POLYCENTRIC WORLD IN SEARCH OF A NEW EXISTENTIAL PARADIGM
Authors: Volodin A. G. 
Published: April 2024

The article examines the evolution of the theories of socio-economic modernization at the end of the XX – first quarter of the XXI century. In the last century, creative rivalry took place between three main ideological and theoretical trends – West-centrist, national-statist and left-wing radical. The difficulties of transforming the complex socio-economic structure of transitional societies have predetermined the gradual loss of the influence of the West-centrist trend and the increasing importance of national-statist and left-wing radical сurrents of thought in the system of knowledge about developing countries. The “truncated globalization” and the “Washington consensus” resulted in the collapse of the monocentric world order and put the development paradigm at the center of the search for a new model of human evolution. Today, development is objectively becoming an imperative for the modernization of all societies, including those of the industrialized nations. The “Development agenda” is, therefore, emerging as an important precondition for the formation of a new, polycentric model of international relations, which is based on the principles of dialogue and interaction between States and civilizations.
Determination of Mahkota Gold Pringsewu Customer Satisfaction
Authors: Wulandari Adellia , Warganegara Tri Lestira Putri 
Published: April 2024

Because of their abundance, Pringsewu's gold stores face fierce competition. Service quality, product quality, product design, and gold cleaning quality are what distinguish one business from the others and help it maintain customer loyalty. The goal of this study is to discover and explain how marketing messages and product quality influence customer satisfaction. This research takes a quantitative approach. There were 110 participants in this research overall. Using the Simple Random Sampling approach, 86 respondents were selected from the Mahkota Gold Pringsewu customer base for this study. This study relied on primary data. The data for this study was gathered using a Likert scale questionnaire technique. According to the findings of the study on Determining Customer Satisfaction at Mahkota Gold Pringsewu, there is a positive and significant relationship between product quality and customer satisfaction; there is also a positive and significant relationship between product quality and marketing communication, and there is a positive and significant relationship between the two for Mahkota Gold Pringsewu customers. This implies that high-quality products and marketing messages have a big influence on consumer happiness.
A Comparative Evaluation of Error Processing Performance and its Relationship with Cognitive Function in Patients with Alzheimer’s Disease, Individuals with Mild Cognitive Impairment, and Normal Controls Using the Event-Related Potentials
Authors: Hedayatjoo Mohammad , Tehrani-Doost Mehdi , Vahabi Zahra , Akbarfahimi Malahat , Khosrowabadi Reza 
Published: April 2024

Background: Some pathological changes occur in patients with Alzheimer’s disease (AD) prior to the onset of clinical symptoms. Objective: In the present study, we aimed to investigate the potential of event-related potential (ERP) components in error processing performance as a neuromarker of mild cognitive impairment (MCI) and transition to AD and their relation with cognitive functions. Methods: We conducted an evaluation of 16 patients diagnosed with AD, 16 patients with MCI, and 15 normal controls using three subtests from the Cambridge Neuropsychological Testing Automated Battery (CANTAB). The ERP components of error processing were extracted and compared among the three groups using a modified version of the Eriksen flanker task. Additionally, we assessed the correlation between the cognitive results and the ERP components. Results: Significant differences were observed among the three groups in terms of providing correct responses following errors and the amplitude of error-related negativity (ERN). These differences were also significant between all paired groups. Regarding other ERP components of error processing and the peak latency of ERN, no significant differences were observed among the three groups. The findings revealed that the spatial working memory and new learning were correlated with the amplitude of ERN. Conclusions: In the context of error processing performance, both the accuracy of responses following an error and the amplitude of ERN can be considered as indicators of MCI and its progression to AD. The present findings do not support the use of other error processing components as differential markers in the three groups.
Predictive Modeling Using a Composite Index of Sleep and Cognition in the Alzheimer’s Continuum: A Decade-Long Historical Cohort Study
Authors: Yu Xianfeng , Deng Shuqing , Liu Junxin , Zhang Mingkai , Zhang Liang , Li Ruixian , Zhang Wei , Han Ying 
Published: April 2024

Background: Sleep disturbances frequently affect Alzheimer’s disease (AD), with up to 65% patients reporting sleep-related issues that may manifest up to a decade before AD symptoms. Objective: To construct a nomogram that synthesizes sleep quality and cognitive performance for predicting cognitive impairment (CI) conversion outcomes. Methods: Using scores from three well-established sleep assessment tools, Pittsburg Sleep Quality Index, REM Sleep Behavior Disorder Screening Questionnaire, and Epworth Sleepiness Scale, we created the Sleep Composite Index (SCI), providing a comprehensive snapshot of an individual’s sleep status. Initially, a CI conversion prediction model was formed via COX regression, fine-tuned by bidirectional elimination. Subsequently, an optimized prediction model through COX regression, depicted as a nomogram, offering predictions for CI development in 5, 8, and 12 years among cognitively unimpaired (CU) individuals. Results: After excluding CI patients at baseline, our study included 816 participants with complete baseline and follow-up data. The CU group had a mean age of 66.1±6.7 years, with 36.37% males, while the CI group had an average age of 70.3±9.0 years, with 39.20% males. The final model incorporated glial fibrillary acidic protein, Verbal Fluency Test and SCI, and an AUC of 0.8773 (0.792–0.963). Conclusions: In conclusion, the sleep-cognition nomogram we developed could successfully predict the risk of converting to CI in elderly participants and could potentially guide the design of interventions for rehabilitation and/or cognitive enhancement to improve the living quality for healthy older adults, detect at-risk individuals, and even slow down the progression of AD.
The effects of neuro-vestibular-ocular exercises and myofascial release on proprioception and performance in football players with chronic ankle instability
Authors: Kocakılıç Büşra , Çil Elif Tuğçe 
Published: April 2024

BACKGROUND AND PURPOSE: Football players often use quick change of direction, sudden acceleration and explosive movements. This is why chronic ankle instability is one of the most common conditions affecting this athlete population. This study investigates the effects of neuro-vestibular-ocular exercises and myofascial release on proprioception and performance in football players with chronic ankle instability. MATERIALS AND METHODS: This randomized controlled clinical trial included 60 football players aged 18–30. The players were randomly divided into two groups. The first group (NVOEG, [Formula: see text]30) was included in the Neuro-Vestibular-ocular exercise training program, while the myofascial release was applied to the second group (MRHOG, [Formula: see text]30). Both protocols were applied for eight weeks. The participants’ Cumberland Ankle Instability Tool (CAIT) scores were assessed before and after the intervention. Proprioception was evaluated by using the joint position sense test. Additionally, kick speed (KS), 30-m sprint, zig-zag agility test (ZAT) and Landing error score system (LESS) tests were applied to evaluate their performance. RESULTS: Post-rehabilitation scores showed significant differences in proprioception and performance parameters compared to pre-scores in both groups. (p<0.05). Significant differences were observed between the NVOEG and MRHOG in the post-test scores, including CAIT for unstable and stable ankle, proprioception for unstable ankle, LESS, ZAT with ball performance, and 30-meter sprint test. CONCLUSIONS: The neuro-vulvular-ocular exercise training protocol had superior results in terms of proprioception and performance parameters in chronic ankle instability management for football players.
A user-friendly deep learning application for accurate lung cancer diagnosis
Authors: Tai Duong Thanh , Nhu Nguyen Tan , Tuan Pham Anh , Sulieman Abdelmoneim , Omer Hiba , Alirezaei Zahra , Bradley David , Chow James C.L. 
Published: April 2024

BACKGROUND: Accurate diagnosis and subsequent delineated treatment planning require the experience of clinicians in the handling of their case numbers. However, applying deep learning in image processing is useful in creating tools that promise faster high-quality diagnoses, but the accuracy and precision of 3-D image processing from 2-D data may be limited by factors such as superposition of organs, distortion and magnification, and detection of new pathologies. The purpose of this research is to use radiomics and deep learning to develop a tool for lung cancer diagnosis. METHODS: This study applies radiomics and deep learning in the diagnosis of lung cancer to help clinicians accurately analyze the images and thereby provide the appropriate treatment planning. 86 patients were recruited from Bach Mai Hospital, and 1012 patients were collected from an open-source database. First, deep learning has been applied in the process of segmentation by U-NET and cancer classification via the use of the DenseNet model. Second, the radiomics were applied for measuring and calculating diameter, surface area, and volume. Finally, the hardware also was designed by connecting between Arduino Nano and MFRC522 module for reading data from the tag. In addition, the displayed interface was created on a web platform using Python through Streamlit. RESULTS: The applied segmentation model yielded a validation loss of 0.498, a train loss of 0.27, a cancer classification validation loss of 0.78, and a training accuracy of 0.98. The outcomes of the diagnostic capabilities of lung cancer (recognition and classification of lung cancer from chest CT scans) were quite successful. CONCLUSIONS: The model provided means for storing and updating patients’ data directly on the interface which allowed the results to be readily available for the health care providers. The developed system will improve clinical communication and information exchange. Moreover, it can manage efforts by generating correlated and coherent summaries of cancer diagnoses.
УKРПОЛБАТ – ВАЖЛИВИЙ ЕТАП В ІСТОРІЇ РОЗВИТКУ УКРАЇНСЬКО-ПОЛЬСЬКИХ ВІЙСЬКОВИХ ВІДНОСИН
Authors: Фуртес Олексій Олександрович 
Published: April 2024

У статті розглянуто історичний шлях спільної українсько-польської військової частини – Українсько-Польського батальйону миротворчих сил (далі – УкрПолбат) в контексті історії розвитку українсько-польських військових відносин. Показано ґенезу, становлення та розвиток батальйону в його основних доленосних подіях, особливо під час його застосування в період з 2000 – 2010 рр. у Косові. Проаналізовано та надано оцінку змісту головних заходів, що відбувалися за період функціонування УкрПолбату, зокрема, участь у спільних навчаннях та у миротворчій місії в Косові. Доведено, що період функціонування УкрПолбату став часом формування довіри, дружби і стратегічного партнерства між Україною і Польщею, готовністю разом долати виклики і загрози, що повстають перед країнами. Набутий УкрПолбатом досвід став вкрай важливим при формуванні наступної спільної військової частини – литовсько-польсько-української бригади, яка і стане предметом наших подальших досліджень.
ТРАНСПОРТНІ ПРОБЛЕМИ НА ПРИФРОНТОВИХ ТЕРИТОРІЯХ ВОЛИНІ У РОКИ ПЕРШОЇ СВІТОВОЇ ВІЙНИ
Authors: Денисюк Василь Іванович 
Published: April 2024

У статті проаналізовано функціонування транспорту на прифронтових територіях Волинської губернії у роки Першої світової війни. З'ясовано межі поняття «прифронтові території». Встановлено стан справ на залізниці та в транспортній системі загалом у регіоні напередодні війни. Охарактеризовано ключові зміни у функціонуванні транспорту після початку війни. Визначено та проаналізовано головні фактори розвитку процесів у транспортній галузі.
Встановлено стрижневі проблеми функціонування залізниці в умовах війни. Проаналізовано ключові елементи зростання навантаження на транспортну систему Волинської губернії. Охарактеризовано головні наслідки системних проблем, що виникли та ускладнювалися у роки війни на залізниці. З'ясовано ключове значення транспортних вузлів.
«ПІДКУПИВ ТИХ, КОГО НЕ ЗМІГ ПОДОЛАТИ В БОЮ»: ВІЙНА З АВАРАМИ КОРОЛЯ АВСТРАЗІЇ СИГІБЕРТА І
Authors: Лагодич Володимир Юрійович 
Published: April 2024

Конгломерат монголоїдних кочовиків аварів, мігрувавши на терени Центрально-Східної Європи протягом 60–х років VI ст. зі степів Передньої Азії, був швидко включений у систему дипломатичних зв’язків регіону. Одним із головних каталізаторів цього процесу була дипломатія Візантійської імперії. У подальші роки, у зв’язку з економічним та мілітарним ослабленням Ромеї на Балканах, утворена кочовиками протодержава, відома в історіографії як Аварський каганат, розгорнула активну зовнішню політику супроти Імперії. При цьому аварський каган Баян І розглядав у якості потенційного вектора експансії землі на захід від Віденського лісу – терени розділеного Королівства франків, і передусім королівство Австразію.
На відміну від зносин із Ромеєю, які характеризувались нестабільністю: укладенням короткочасних мирних договорів та участі дипломатичних посольств з обох сторін, відносини Баяна з австразійським королем Сигібертом І (561–575) почались із набігів кочовиків на землі франків. Участь послів з боку аварів та франків була при цьому мінімальною. Відрізнялись своїм характером і бойові дії – на відміну від наступників Юстиніана Великого (527–565), а також через специфіку еволюції влади у германських королівствах на руїнах Західного Риму, Сигіберт не цурався брати безпосередню участь у відбитті атак «гунів». Це зрештою завершилось взяттям монарха франків у полон та укладенням довготривалого мирного договору з аварами, що не порушувався у подальші два століття.
У статті на основі повідомлень франкських, візантійських та лангобардських істориків другої половини VI cт. – ІХ ст. розглянуто особливості внутрішньополітичного розвитку Королівства Франків та Аварського каганату протягом першої половини VI ст. Здійснена спроба відтворити хронологію війни з аварами короля Австразії Сигіберта І та обставини, що сприяли розгортанню конфлікту. Проаналізовано фактори, які сприяли експансії аварів щодо франкського королівства Австразії, а також виходу Держави Сигіберта та кочової політії зі стану збройного протистояння.
Deep learning-assisted concentration gradient generation for the study of 3D cell cultures in hydrogel beads of varying stiffness
Authors: Anagnostidis Vasileios , Tiwari Anuj , Gielen Fabrice 
Published: April 2024

The study of dose-response relationships underpins analytical biosciences. Droplet microfluidics platforms can automate the generation of microreactors encapsulating varying concentrations of an assay component, providing datasets across a large chemical space in a single experiment. A classical method consists in varying the flow rate of multiple solutions co-flowing into a single microchannel (producing different volume fractions) before encapsulating the contents into water-in-oil droplets. This process can be automated through controlling the pumping elements but lacks the ability to adapt to unpredictable experimental scenarios, often requiring constant human supervision. In this paper, we introduce an image-based, closed-loop control system for assessing and adjusting volume fractions, thereby generating unsupervised, uniform concentration gradients. We trained a shallow convolutional neural network to assess the position of the laminar flow interface between two co-flowing fluids and used this model to adjust flow rates in real-time. We apply the method to generate alginate microbeads in which HEK293FT cells could grow in three dimensions. The stiffnesses ranged from 50 Pa to close to 1 kPa in Young modulus and were encoded with a fluorescent marker. We trained deep learning models based on the YOLOv4 object detector to efficiently detect both microbeads and multicellular spheroids from high-content screening images. This allowed us to map relationships between hydrogel stiffness and multicellular spheroid growth.
Persistent hypercalcaemia associated with two pathogenic variants in the CYP24A1 gene and a parathyroid adenoma—a case report and review
Authors: Leszczyńska Dorota , Szatko Alicja , Latocha Julia , Kochman Magdalena , Duchnowska Maria , Wójcicka Anna , Misiorowski Waldemar , Zgliczyníski Wojciech , Glinicki Piotr 
Published: April 2024

Introduction24-Hydroxylase, encoded by the CYP24A1 gene, is a crucial enzyme involved in the catabolism of vitamin D. Loss-of-function mutations in CYP24A1 result in PTH-independent hypercalcaemia with high levels of 1,25(OH)2D3. The variety of clinical manifestations depends on age, and underlying genetic predisposition mutations can lead to fatal infantile hypercalcaemia among neonates, whereas adult symptoms are usually mild.Aim of the studyWe report a rare case of an adult with primary hyperparathyroidism and loss-of-function mutations in the CYP24A1 gene and a review of similar cases.Case presentationWe report the case of a 58-year-old woman diagnosed initially with primary hyperparathyroidism. Preoperatively, the suspected mass adjoining the upper pole of the left lobe of the thyroid gland was found via ultrasonography and confirmed by 99mTc scintigraphy and biopsy as the parathyroid gland. The patient underwent parathyroidectomy (a histopathology report revealed parathyroid adenoma), which led to normocalcaemia. After 10 months, vitamin D supplementation was introduced due to deficiency, and the calcium level remained within the reference range. Two years later, biochemical tests showed recurrence of hypercalcaemia with suppressed parathyroid hormone levels and elevated 1,25(OH)2D3 concentrations. Further investigation excluded the most common causes of PTH-independent hypercalcaemia, such as granulomatous disease, malignancy, and vitamin D intoxication. Subsequently, vitamin D metabolites were measured using LC–MS/MS, which revealed high levels of 25(OH)D3, low levels of 24,25(OH)2D3 and elevated 25(OH)2D3/24,25(OH)2D3 ratios, suggesting a defect in vitamin D catabolism. Molecular analysis of the CYP24A1 gene using the NGS technique revealed two pathogenic variants: p.(Arg396Trp) and p.(Glu143del) (rs114368325 and rs777676129, respectively).ConclusionsThe diagnostic process for hypercalcaemia becomes complicated when multiple causes of hypercalcaemia coexist. The measurement of vitamin D metabolites using LC–MS/MS may help to identify carriers of CYP24A1 mutations. Subsequent molecular testing may contribute to establishing the exact frequency of pathogenic variants of the CYP24A1 gene and introducing personalized treatment.
A fault diagnosis method for flexible converter valve equipment based on DSC-BIGRU-MA
Authors: Guo Jianbao , Liu Hang , Feng Lei , Zu Lifeng 
Published: April 2024

Introduction: Precise fault diagnosis is crucial for enhancing the reliability and lifespan of the flexible converter valve equipment. To address this issue, depthwise separable convolution, bidirectional gate recurrent unit, and multi-head attention module (DSC-BiGRU-MAM) based fault diagnosis approach is proposed.Methods: By DSC and BiGRU operation, the model can capture the correlation between local features and temporal information when processing sequence data, thereby enhancing the representation ability and predictive performance of the model for complex sequential data. In addition, by incorporating a multi-head attention module, the proposed method dynamically learns important information from different time intervals and channels. The proposed MAM continuously stimulates fault features in both time and channel dimensions during training, while suppressing fault independent expressions. As a result, it has made an important contribution to improving the performance of the fault diagnosis model.Results and Discussion: Experimental results demonstrate that the proposed method achieves higher accuracy compared to existing methods, with an average accuracy of 95.45%, average precision of 88.67%, and average recall of 89.03%. Additionally, the proposed method has a moderate number of model parameters (17,626) and training time (935 s). Results indicate that the proposed method accurately diagnoses faults in flexible converter valve equipment, especially in real-world situations with noise overlapping signals.