bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of threatening information on interpersonal responses to pain
Authors: Jackson Todd , Huang Xiting , Chen Hong , Phillips Heath 
Published: July 2008

ABSTRACTEmerging evidence indicates that meanings attributed to pain contribute to tolerance and coping among affected individuals. However, links between pain appraisals and coping responses have received little attention within a broader interpersonal context. In this experiment, effects of appraisal on pain tolerance and coping were examined in adult dyads. Eighty‐six acquaintance/friend pairs were randomly assigned to the role of Participant in a cold pressor test (CPT) or observer–helper who assisted in coping. Before the task, pairs in the threat condition read about frostbite symptoms and consequences, while those in the reassurance condition read about the safety of the task. In a mixed condition, Participants and Observers read the reassurance and threat passage, respectively. Between‐groups analyses revealed threat group participants had lower pain tolerance and reported less cognitive coping than did participants in other appraisal conditions. Threat group observers reported less attention diversion, coping self‐statements and ignoring in helping their partner than did reassured observers. Pain language was also most prominent in transactions of threatened dyads. Finally, use of attention diversion by observers contributed to pain tolerance, independent of participant factors (reported pain, appraisal condition, reported coping) and pain language in conversations during immersions. The study highlights how appraisal contributes not only to pain tolerance and coping in the affected individual but also to care‐giving efforts of others in their social environment.
Diffusion tensor imaging in the developing human cerebellum with histologic correlation
Authors: Saksena Sona , Husain Nuzhat , Das Vinita , Pradhan Mandakani , Trivedi Richa , Srivastava Savita , Malik Gyanendra K. , Rathore Ram K.S. , Sarma Manoj , Pandey Chandra M. , Gupta Rakesh K. 
Published: July 2008

AbstractDiffusion tensor imaging was performed on 24 freshly aborted human fetuses with gestational age ranging from 20 to 37 weeks to observe age‐related fractional anisotropy changes in cerebellar cortex and cerebellar white matter. Quantitative immunohistochemical analysis was performed for glial fibrillary acidic protein in each fetus molecular layer of cerebellar cortex and myelin basic protein expression was quantified in myelinated areas of the middle cerebellar peduncles. The cerebellar cortical fractional anisotropy reached its peak value at 28 weeks, and then decreased gradually until 37 weeks. The time course of glial fibrillary acidic protein expression paralleled that of fractional anisotropy in the cerebellar cortex from 20 weeks of gestation upto the gestational age at which the fractional anisotropy reached its peak value (28 weeks). In the middle cerebellar peduncles, the fractional anisotropy increased continuously upto 37 weeks of gestational age and showed a significant positive correlation with myelin basic protein immunostained fibers. The fractional anisotropy quantification can be used to assess the migrational and maturation changes during the development of the human fetal cerebellum supported by the immunohistochemical analysis.
Evolution of a high-density electron beam in the field of a super-intense laser pulse
Authors: Kulagin V.V. , Cherepenin V.A. , Hur M.S. , Lee J. , Suk H. 
Published: July 2008

AbstractThe evolution of a high-density electron beam in the field of a super-intense laser pulse is considered. The one-dimensional (1D) theory for the description of interaction, taking into account the space-charge forces of the beam, is developed, and exact solutions for the equations of motion of the electrons are found. It was shown that the length of the high-density electron beam increases slowly in time after initial compression of the beam by the laser pulse as opposed to the low-density electron beam case, where the length is constant on average. Also, for the high-density electron beam, the sharp peak frozen into the density distribution can appear in addition to a microbunching, which is characteristic for a low-density electron beam in a super-intense laser field. Characteristic parameters for the evolution of the electron beam are calculated by an example of a step-like envelope of the laser pulse. Comparison with 1D particle-in-cell simulations shows adequacy of the derived theory. The considered issue is very important for a special two-pulse realization of a Thomson scattering scheme, where one high-intensity laser pulse is used for acceleration, compression and microbunching of the electron beam, and the other probe counter-streaming laser pulse is used for scattering with frequency up-shifting and amplitude enhancement.
Hantavirus disease (nephropathia epidemica) in Belgium: effects of tree seed production and climate
Authors: TERSAGO K. , VERHAGEN R. , SERVAIS A. , HEYMAN P. , DUCOFFRE G. , LEIRS H. 
Published: July 2008

SUMMARYRecently, human cases of nephropathia epidemica (NE) due to Puumala virus infection in Europe have increased. Following the hypothesis that high reservoir host abundance induces higher transmission rates to humans, explanations for this altered epidemiology must be sought in factors that cause bank vole (Myodes glareolus) abundance peaks. In Western Europe, these abundance peaks are often related to high tree seed production, which is supposedly triggered by specific weather conditions. We evaluated the relationship between tree seed production, climate and NE incidence in Belgium and show that NE epidemics are indeed preceded by abundant tree seed production. Moreover, a direct link between climate and NE incidence is found. High summer and autumn temperatures, 2 years and 1 year respectively before NE occurrence, relate to high NE incidence. This enables early forecasting of NE outbreaks. Since future climate change scenarios predict higher temperatures in Europe, we should regard Puumala virus as an increasing health threat.
Outbreak of waterborne hepatitis E in Hyderabad, India, 2005
Authors: SAILAJA B. , MURHEKAR M. V. , HUTIN Y. J. , KURUVA S. , MURTHY S. P. , REDDY K. S. JOWAHER , RAO G. MASTAN , GUPTE M. D. 
Published: July 2008

SUMMARYA large outbreak of hepatitis E occurred in 2005 in Hyderabad, Andhra Pradesh, India. A total of 1611 cases were reported between 1 March and 31 December 2005 (attack rate 40/100 000). The epidemic curve suggested a continuing common source outbreak. Cases were centred around open sewage drains that crossed the old city. The attack rate was significantly higher in neighbourhood blocks supplied by water supply lines that crossed open drains (203/100 000) than in blocks supplied by non-crossing water pipes with a linear trend (38/100 000, P<0·00001). Crossing water pipelines were repaired and the attack rates declined.
The transmission and control of XDR TB in South Africa: an operations research and mathematical modelling approach
Authors: BASU S. , GALVANI A. P. 
Published: July 2008

SUMMARYExtensively drug-resistant tuberculosis (XDR TB) has emerged as a threat to TB control efforts in several high-burden areas, generating international concern. XDR TB is now found in every region of the world, but appears most worrisome in the context of HIV and in resource-limited settings with congregate hospital wards. Here, we examine the emergence and transmission dynamics of the disease, incorporating the mathematical modelling literature related to airborne infection and epidemiological studies related to the operations of TB control programmes in resource-limited settings. We find that while XDR TB may present many challenges in the setting of resource constraints, the central problems highlighted by the emergence of XDR TB are those that have plagued TB programmes for years. These include a slow rate of case detection that permits prolonged infectiousness, the threat of airborne infection in enclosed spaces, the problem of inadequate treatment delivery and treatment completion, and the need to develop health systems that can address the combination of TB and poverty. Mathematical models of TB transmission shed light on the idea that community-based therapy and rapid detection systems may be beneficial in resource-limited settings, while congregate hospital wards are sites for major structural reform.
Ten good reasons to consider biological processes in prevention and intervention research
Authors: Beauchaine Theodore P. , Neuhaus Emily , Brenner Sharon L. , Gatzke-Kopp Lisa 
Published: July 2008

AbstractMost contemporary accounts of psychopathology acknowledge the importance of both biological and environmental influences on behavior. In developmental psychopathology, multiple etiological mechanisms for psychiatric disturbance are well recognized, including those operating at genetic, neurobiological, and environmental levels of analysis. However, neuroscientific principles are rarely considered in current approaches to prevention or intervention. In this article, we explain why a deeper understanding of the genetic and neural substrates of behavior is essential for the next generation of preventive interventions, and we outline 10 specific reasons why considering biological processes can improve treatment efficacy. Among these, we discuss (a) the role of biomarkers and endophenotypes in identifying those most in need of prevention; (b) implications for treatment of genetic and neural mechanisms of homotypic comorbidity, heterotypic comorbidity, and heterotypic continuity; (c) ways in which biological vulnerabilities moderate the effects of environmental experience; (d) situations in which Biology × Environment interactions account for more variance in key outcomes than main effects; and (e) sensitivity of neural systems, via epigenesis, programming, and neural plasticity, to environmental moderation across the life span. For each of the 10 reasons outlined we present an example from current literature and discuss critical implications for prevention.
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Authors: Dawson Geraldine 
Published: July 2008

AbstractAdvances in the fields of cognitive and affective developmental neuroscience, developmental psychopathology, neurobiology, genetics, and applied behavior analysis have contributed to a more optimistic outcome for individuals with autism spectrum disorder (ASD). These advances have led to new methods for early detection and more effective treatments. For the first time, prevention of ASD is plausible. Prevention will entail detecting infants at risk before the full syndrome is present and implementing treatments designed to alter the course of early behavioral and brain development. This article describes a developmental model of risk, risk processes, symptom emergence, and adaptation in ASD that offers a framework for understanding early brain plasticity in ASD and its role in prevention of the disorder.
Executive functions and school readiness intervention: Impact, moderation, and mediation in the Head Start REDI program
Authors: Bierman Karen L. , Nix Robert L. , Greenberg Mark T. , Blair Clancy , Domitrovich Celene E. 
Published: July 2008

AbstractDespite their potentially central role in fostering school readiness, executive function (EF) skills have received little explicit attention in the design and evaluation of school readiness interventions for socioeconomically disadvantaged children. The present study examined a set of five EF measures in the context of a randomized-controlled trial of a research-based intervention integrated into Head Start programs (Head Start REDI). Three hundred fifty-six 4-year-old children (17% Hispanic, 25% African American; 54% girls) were followed over the course of the prekindergarten year. Initial EF predicted gains in cognitive and social–emotional skills and moderated the impact of the Head Start REDI intervention on some outcomes. The REDI intervention promoted gains on two EF measures, which partially mediated intervention effects on school readiness. We discuss the importance of further study of the neurobiological bases of school readiness, the implications for intervention design, and the value of incorporating markers of neurobiological processes into school readiness interventions.
Effects of early intervention on EEG power and coherence in previously institutionalized children in Romania
Authors: Marshall Peter J. , Reeb Bethany C. , Fox Nathan A. , Nelson Charles A. , Zeanah Charles H. 
Published: July 2008

AbstractTwo groups of Romanian children were compared on spectral power and coherence in the electroencephalogram (EEG) in early childhood. One group consisted of previously institutionalized children who had been randomly assigned to a foster care intervention at a mean age of 23 months. The second group had been randomized to remain in institutional care. Because of a policy of noninterference, a number of these children also experienced placement into alternative family care environments. There were minimal group differences between the foster care and institutionalized groups in EEG power and coherence across all measured frequency bands at 42 months of age. However, age at foster care placement within the foster care group was correlated with certain measures of EEG power and coherence. Earlier age at foster care placement was associated with increased alpha power and decreased short-distance EEG coherence. Further analyses separating age at placement from duration of intervention suggest that this effect may be more robust for EEG coherence than EEG band power. Supplementary analyses examined whether the EEG measures mediated changes in intellectual abilities within the foster care children, but no clear evidence of mediation was observed.
Biological processes in prevention and intervention: The promotion of self-regulation as a means of preventing school failure
Authors: Blair Clancy , Diamond Adele 
Published: July 2008

AbstractThis paper examines interrelations between biological and social influences on the development of self-regulation in young children and considers implications of these interrelations for the promotion of self-regulation and positive adaptation to school. Emotional development and processes of emotion regulation are seen as influencing and being influenced by the development of executive cognitive functions, including working memory, inhibitory control, and mental flexibility important for the effortful regulation of attention and behavior. Developing self-regulation is further understood to reflect an emerging balance between processes of emotional arousal and cognitive regulation. Early childhood educational programs that effectively link emotional and motivational arousal with activities designed to exercise and promote executive functions can be effective in enhancing self-regulation, school readiness, and school success.
Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems
Authors: Lewis Marc D. , Granic Isabela , Lamm Connie , Zelazo Philip David , Stieben Jim , Todd Rebecca M. , Moadab Ida , Pepler Debra 
Published: July 2008

AbstractChildren's behavior problems may stem from ineffective cortical mechanisms for regulating negative emotions, and the success of interventions may depend on their impact on such mechanisms. We examined neurophysiological markers associated with emotion regulation in children comorbid for externalizing and internalizing problems before and after treatment. We hypothesized that treatment success would correspond with reduced ventral prefrontal activation, and increased dorsomedial prefrontal activation, at the time point of an event-related potential (ERP) associated with inhibitory control. Twenty-seven 8- to 12-year-old children (with usable data) were tested before and after a 14-week community-based treatment program and assessed as to improvement status. Fifteen 8- to 12-year-olds from the normal population (with usable data) were tested over the same interval. All children completed an emotion-induction go/no-go task while fitted with a 128-channel electrode net at each test session. ERP amplitudes, and estimates of cortical activation in prefrontal regions of interest, were measured at the peak of the “inhibitory” N2 and compared between improvers, nonimprovers, and nonclinical children. ERP amplitudes showed no group differences. However, improvers showed an overall reduction in ventral prefrontal activation from pretreatment to posttreatment, bringing them in line with nonclinical children, whereas ventral activation remained high for nonimprovers. Both improvers and nonimprovers showed high dorsal activation relative to nonclinical children. Supplementary analyses indicated that only ventral prefrontal regions, and only within the N2 time window, showed decreased activity from pre- to posttreatment, suggesting changes in regulatory processes rather than in overall emotional arousal. These cortically mediated changes may permit a reduction in the overengaged, rigid style of emotion regulation characteristic of children with behavior problems.
Intervention effects on foster parent stress: Associations with child cortisol levels
Authors: Fisher Philip A. , Stoolmiller Mike 
Published: July 2008

AbstractFoster children exhibit high rates of atypical neuroendocrine functioning compared to children in the general population. In particular, alterations in the daytime diurnal activity of the hypothalamic–pituitary–adrenal (HPA) axis have been observed in foster children, often characterized by blunted salivary cortisol levels (i.e., low morning levels that remain low throughout the day). There is emerging evidence that therapeutic interventions for foster children can affect this pattern of HPA axis activity, but the specific intervention components responsible for change have not been fully explicated. Within a randomized trial to evaluate a therapeutic intervention for foster preschoolers (n= 57 intervention condition;n= 60 comparison condition;n= 60 community comparison condition), the present study examined whether diurnal cortisol activity was associated with caregiver self-reported stress in response to child problem behavior. Results showed immediate reductions in caregiver stress that were sustained through 12 months postbaseline in the intervention condition. In contrast, caregivers in the regular foster care condition showed higher rates of stress across time and increased stress sensitivity to child problem behaviors. In addition, among caregivers in regular foster care, higher self-reported stress was associated with lower morning cortisol levels and more blunted diurnal cortisol activity. These results provide evidence that interventions can simultaneously impact caregiver stress and buffer children from the negative impacts of caregiver stress on HPA axis regulation.
Adhesion molecules in the regulation of CNS myelination
Authors: Laursen Lisbeth S. , Ffrench-Constant Charles 
Published: July 2008

AbstractMyelination is necessary both for rapid salutatory conduction and the long-term survival of the axon. In the CNS the myelin sheath is formed by the oligodendrocytes. Each oligodendrocyte myelinates several axons and, as the number of wraps around each axon is determined precisely by the axon diameter, this requires a close, highly regulated interaction between the axons and each of the oligodendrocyte processes. Adhesion molecules are likely to play an important role in the bi-directional signalling between axon and oligodendrocyte that underlies this interaction. Here we review the current knowledge of the function of adhesion molecules in the different phases of oligodendrocyte differentiation and myelination, and discuss how the properties of these proteins defined by other cell biological systems indicates potential roles in oligodendrocytes. We show how the function of a number of different adhesion and cell–cell interaction molecules such as polysialic acid neural cell adhesion molecule, Lingo-1, Notch, neuregulin, integrins and extracellullar matrix proteins provide negative and positive signals that coordinate the formation of the myelin membrane. Compiling this information from a number of different cell biological and genetic experiments helps us to understand the pathology of multiple sclerosis and direct new areas of research that might eventually lead to potential drug targets to increase remyelination.
Estimating the efficiency of benzodiazepines on GABAAreceptors comprising γ1 or γ2 subunits
Authors: Baburin I , Khom S , Timin E , Hohaus A , Sieghart W , Hering S 
Published: July 2008

Background and purpose:Heterologous expression of α1, β2 and γ2S(γ1) subunits produces a mixed population of GABAAreceptors containing α1β2 or α1β2γ2S(γ1) subunits. GABA sensitivity (lower in receptors containing γ1 or γ2S subunits) and the potentiation of GABA‐activated chloride currents (IGABA) by benzodiazepines (BZDs) are dependent on γ2S(γ1) incorporation. A variable γ subunit incorporation may affect the estimation ofIGABApotentiation by BZDs. We propose an approach for estimation of BZD efficiency that accounts for mixed population of α1β2 and α1β2γ2S(γ1) receptors.Experimental approach:We investigated the relation between GABA sensitivity (EC50) and BZD modulation by analysing triazolam‐, clotiazepam‐ and midazolam‐induced potentiation ofIGABAinXenopusoocytes under two‐microelectrode voltage clamp.Key results:PlottingEC50versus BZD‐induced shifts of GABA concentration‐response curves (ΔEC50(BZD)) of oocytes injected with different amounts of α1, β2 and γ2S(γ1) cRNA (1:1:1–1:1:10) revealed a linear regression between γ2S(γ1)‐mediated reduction of GABA sensitivity (EC50) and ΔEC50(BZD). The slope factors of the regression were always higher for oocytes expressing α1β2γ1 subunit receptors (1.8±0.1 (triazolam), 1.6±0.1 (clotiazepam), 2.3±0.2 (midazolam)) than for oocytes expressing α1β2γ2S receptors (1.4±0.1 (triazolam), 1.4±0.1 (clotiazepam), 1.3±0.1 (midazolam)). Mutant GABAAreceptors (α1β2‐R207Cγ2S) with lower GABA sensitivity showed higher drug efficiencies (slope factors=1.1±0.1 (triazolam), 1.1±0.1 (clotiazepam), 1.2±0.1 (midazolam)).Conclusions and implications:Regression analysis enabled the estimation of BZD efficiency when variable mixtures of α1β2 and α1β2γ2S(γ1) receptors are expressed and provided new insights into the γ2S(γ1) dependency of BZD action.British Journal of Pharmacology(2008)155, 424–433; doi:10.1038/bjp.2008.271; published online 7 July 2008