bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA‐MEG3 Mediated Diabetic Cerebral Ischemia–Reperfusion Injury‐Induced Apoptosis via Modulating Interaction Between Annexin A2 and Akt in Mitochondria
Authors: Zhou Wanqing , Tan Chongyi , Xiong Di , Chen Cheng , Zhao Yanfei , Xie Yongqiu , Sun Bei , Wang Zhihua , Xia Pingping , Ye Zhi 
Published: February 2025

ABSTRACTBackgroundIn clinical domains, encompassing neurosurgery and macrovascular cardiac procedures, certain interventions result in cerebral ischemia‐ reperfusion injury (CIRI). Diabetes mellitus (DM) increases the risk of CIRI and worsens the severity of neurological impairment. It was documented that lncRNA‐MEG3 contributed to the pathogenesis of CIRI. However, the pivotal significance of lncRNA‐MEG3 in diabetic CIRI has never been studied.AimsThis study's aims were two‐fold, to (1) figure out the influence of lncRNA‐MEG3 on neurological dysfunction subsequent to diabetic cerebral ischemic injury, (2) elucidate its potential role in mitochondria‐related apoptosis via modulating the Anxa2 signaling pathway.Materials and MethodsWe mainly collected plasma from clinical patients to measure the expression of lncRNA‐MEG3, and explored the molecular mechanism of lncRNA‐MEG3 in CIRI combined with DM by immunofluorescence, western blot, co‐ip and other molecular biology experiments in rat MACO+DM model and cellular OGD/R+HG model.ResultsLncRNA‐MEG3 expression in DM+AIS cases was remarkably higher than that in cases with AIS and healthy controls. Moreover, lncRNA‐MEG3 expression was strongly linked to the National Institutes of Health Stroke Scale (NIHSS) score. Additionally, the findings unveiled that lncRNA‐MEG3 depletion alleviated neurological impairments following CIRI in diabetic rats, and cellular death resulted from Oxygen‐glucose deprivation (OGD) plus hyperglycemic reperfusion in rat brain microvascular endothelial cells (RBMVECs) that was concomitant with the increased phosphorylation of Annexin A2 (Anxa2) at Tyr23. Meanwhile, over expression of Anxa2, identified as a lncRNA‐MEG3‐associated mitochondrial protein, remarkably suppressed mitochondria‐derived apoptosis. Importantly, lncRNA‐MEG3 knockdown enhanced the mitochondrial translocation of Anxa2 via promoting its phosphorylation at Tyr23 in OGD+HG‐treated RBMVECs. Furthermore, Anxa2 enhanced Akt phosphorylation at Ser473 and bound to Akt in mitochondria, which was involved in lncRNA‐MEG3 depletion‐induced neuroprotection. However, lncRNA‐MEG3 mobilized to mitochondria in a Plectin‐dependent manner and subsequently impeded the interaction between p‐Anxa2 and p‐Akt.Discussion and ConclusionThe outcomes provided clinical evidence that lncRNA‐MEG3 appeared as an unfavorable prognostic factor for diabetic CIRI and revealed that lncRNA‐MEG3 knockdown could be protective against diabetic CIRI‐induced mitochondria‐related apoptosis through modulating Anxa2 binding to Akt in mitochondria.
Nonconsumptive effects of the predator Hippodamia convergens reduce probing behavior of Diaphorina citri on Citrus sinensis
Authors: Antolínez Carlos A. , Szejbak Krzysztof , Rivera Monique J. 
Published: February 2025

AbstractNonconsumptive effects (NCEs) impact predator–prey interactions when the presence of a predator affects behavior, physiology, or population dynamics of the prey species without resulting in consumption. NCEs are critical to understanding ecological interactions broadly and in an applied manner, when addressing the efficacy of biological control within agroecosystems. In this study, we explore the impact of cues from the predator, Hippodamia convergens Guérin‐Méneville (Coleoptera: Coccinellidae), on the probing and feeding behavior of Diaphorina citri Kuwayama (Hemiptera: Psyllidae), the Asian citrus psyllid (ACP), which transmits the causal bacteria of Huanglongbing (HLB) disease of citrus (Rutaceae). Due to wide‐spread HLB incidence and insecticide resistance, it has become critical to better understand the activity of biological control agents within the HLB–ACP pathosystem. Utilizing electropenetrography (EPG), we investigated the feeding behavior of ACP exposed to the predator H. convergens or exposed to the chemical trails H. convergens produce while foraging. Overall, ACP detected H. convergens cues and responded by avoiding probing, although the extent of this response varied depending on the type of cue perceived. When H. convergens was present in the leaf but unable to reach the psyllid, ACP were slower to initiate probing and spent less time overall on probing and feeding from the xylem. In contrast, when exposed to H. convergens foraging cues without the beetle present, ACP initiated probing quicker than when the beetle was present and had a shorter total probing time compared to the control, with no other parameters being affected. Interestingly, the H. convergens chemical trail extracts, at two dosages, did not significantly influence ACP probing and feeding, except for a lower proportion of salivation and ingestion events into the phloem at the lower test dose. Our results suggest ACP exhibits avoidance behaviors in response to H. convergens cues, leading to a reduction in feeding, which suggests the maintenance of agroecosystem health through preservation of insect community diversity may be overlooked as an additive factor in vector management.
Examining Discussion Networks of a Nonviolent Immigrant Religious Group: How Individual Attitudes and Behaviours Influence Tie Formation
Authors: Massey Zachary B. , Lee Sun Kyong 
Published: February 2025

ABSTRACTThis study used social network analysis to examine discussion networks within an immigrant religious organization consistent with a nonviolent ideological group. Specifically, participants from a Vietnamese Buddhist monastery listed members with whom they discussed religious issues and whom they perceived influential, and members’ attitudes and behaviours towards nonviolence were measured. A valued exponential random graph modelling examined whether individual attributes (i.e., attitudes and behaviours) explained discussion tie formation and its intensity above and beyond the network structural effects. Results showed that members with more positive attitudes towards vegetarianism and those who practiced vegetarianism strictly were more likely to form strong ties with other members. An alternative model of social selection based on attitude and behavioural homophily was tested but did not have a better goodness of fit. Research findings inform future research investigating social influence and social selection within immigrant religious groups by testing different network mechanisms.
Data‐driven robust multiproduct pricing with fairness concerns
Authors: Wang Zude , Wu Yuwei , Chen Caihua , Li Min 
Published: February 2025

AbstractDue to the prevalence of data‐driven pricing, managers are more capable of customizing prices for different people, times, and places. This raises doubts about the robustness and the fairness of those automatic pricing programs. Therefore, this paper investigates a data‐driven pricing approach where robustness and fairness are automatically triggered. For this pricing problem, we present a distributionally robust optimization model with the Wasserstein ambiguity set and a novel price fairness constraint. Furthermore, the model is extended to accommodate a two‐period setting. To the best of our knowledge, this is the first study that considers such a combination. To solve this problem more efficiently, we develop an alternating direction method of multipliers (ADMM) based algorithm by utilizing the separable structure of this pricing model. The numerical results using simulated and real data show that the ADMM‐based algorithm is significantly faster than the state‐of‐the‐art commercial solver GUROBI. Finally, we demonstrate the benefits of our approach in enhancing revenue, robustness, and fairness for pricing strategy under demand uncertainty.
Development and Validation of Healthy and Unhealthy Plant‐Based Diet Propensity Scores in European Children, Adolescents and Adults From the I.Family Study
Authors: Masip Guiomar , Goerdten Jantje , Asif Tooba , Hebestreit Antje , Hunsberger Monica , Lissner Lauren , Molnar Denes , Pala Valeria , Russo Paola , Tornaritis Michael , Veidebaum Toomas , Wolters Maike , Moreno Luis A. , Bogl Leonie H. 
Published: February 2025

ABSTRACTIntroductionPlant‐based dietary patterns may reduce the risk of chronic diseases, but their benefits and risks in younger populations remain unclear due to variations in diet quality and nutrient adequacy. Robust tools to assess adherence to these patterns are essential. The aim of this study was to develop and validate three plant‐based diet propensity (PBDP) scores – overall, healthy and unhealthy – to capture plant‐based dietary patterns and assess their associations with nutrient intakes and health indicators in children, adolescents and adults.MethodsThis cross‐sectional study of children, adolescents and adults used data from the I.Family study (n = 15,780 participants) from eight European countries. Dietary intake was assessed using a food frequency questionnaire. The overall PBDP score was constructed by categorising all plant‐based food groups as positive and animal‐based food groups as negative. The healthy PBDP emphasised healthy plant‐based food groups, whereas the unhealthy PBDP emphasised less healthy plant‐based food groups. Validity was assessed through correlations with nutrient intakes and comparison across demographic groups. Associations with health indicators were also analysed.ResultsPBDP scores showed expected associations with nutrient intakes. Higher overall and healthy PBDP scores were observed in females, adults, individuals with higher parental educational levels and those from Belgium and Spain. The healthy PBDP score was associated with higher HDL cholesterol, improved bone stiffness and lower triglycerides. The unhealthy PBDP score was associated with lower HDL cholesterol in adults, but not in children or adolescents.ConclusionPBDP scores describe plant‐based dietary patterns across demographic groups and are valid and reliable in adults. The findings highlight challenges in assessing dietary patterns in children and adolescents. Future research should address these challenges to enhance the validity of PBDP scores in younger populations and further explore their potential in guiding dietary recommendations across all age groups.
Discrimination Faced by Male Nurses and Male Midwives: A Systematic Review and Meta‐Synthesis
Authors: Wong Melanie Li Ling , Koh Siew Lin Serena , Teo Wei Zhou , Eng Kok Wee , Shorey Shefaly 
Published: February 2025

ABSTRACTAimTo consolidate and appraise available evidence on the experiences and perceptions of male nurses and male midwives facing discrimination.DesignQualitative systematic review. This review was informed by the Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA).MethodsThe Critical Appraisal Skills Program checklist was used to appraise included articles, and extracted data were meta‐summarised and meta‐synthesised using Sandelowski and Barroso's two‐step approach.Data SourcesPubMed, EMBASE, CINAHL, Scopus, Web of Science, PsycINFO, Cochrane Library, ProQuest (Dissertations and Theses Global) and ClinicalTrials.gov were sourced from the inception to December 2022.ResultsA total of 21 studies were included, involving 283 male nurses and 11 male midwives. Four themes were identified during the meta‐synthesis: (1) It's a ‘women's world’, (2) discrimination within and beyond the workplace, (3) stereotypes and labels and (4) the silver lining.ConclusionThis review offered male nurses' and male midwives' perspectives on discrimination faced in nursing. There is a need to ensure gender equality in the nursing profession by reinforcing the importance and value of employing men in this profession.ImplicationsFuture research should focus on examining the experiences of male nursing students and other healthcare stakeholders to understand discrimination faced by men in nursing from varied geographical and cultural backgrounds. The findings may provide helpful insights for planning supportive interventions, institutional adjustments, legislative changes, educational initiatives and research that benefit male nurses and male midwives.ImpactThis qualitative systematic review consolidated and meta‐synthesised the available evidence on male nurses' and male midwives' experiences of discrimination. These findings contribute to the understanding of male nurses and male midwives as a gender minority and the need for greater gender equality.Reporting MethodPRISMA.Patient or Public ContributionNo patient or public contribution.
What's the difference between human‐written manuscripts versus ChatGPT‐generated manuscripts involving “human touch”?
Authors: Matsubara Shigeki , Matsubara Daisuke 
Published: February 2025

AbstractAimTo determine whether ChatGPT generates a manuscript with a “human touch” with appropriate inputs, and if yes, what's the difference between human writing versus ChatGPT writing. This is because the presence or absence of human touch may characterize human writing.MethodsA descriptive study. The first author wrote a Disagreement Letter (Letter 1). Then, disagreement points and “human touch” were provided as input into ChatGPT‐4 and tasked with generating a Letter (Letter 2). The authors, seven experienced researchers, and ChatGPT evaluated the readability of Letters 1 and 2.ResultsThe authors, researchers, and ChatGPT, all reached the same conclusions: the human‐written Letter 1 and the ChatGPT‐generated Letter 2 had similar readability and similarly involved human touch. Some researchers and ChatGPT recognized slight differences in formal or informal and personal or nonpersonal tones between them, which they considered may not affect paper acceptance.ConclusionsHuman touch is not humans' exclusive possession. The distinction between the human writing versus ChatGPT writing is considered to be present not in the output (manuscript) but in the process of writing, that is, the presence or absence of a joy of writing. Artificial intelligence should aid in enhancing, or at the very least, not impede the human joy. This discussion deserves ongoing exploration.
A Comparative Analysis of Three Large Language Models on Bruxism Knowledge
Authors: Camargo Elisa Souza , Quadras Isabella Christina Costa , Garanhani Roberto Ramos , de Araujo Cristiano Miranda , Stuginski‐Barbosa Juliana 
Published: February 2025

ABSTRACTBackgroundArtificial Intelligence (AI) has been widely used in health research, but the effectiveness of large language models (LLMs) in providing accurate information on bruxism has not yet been evaluated.ObjectivesTo assess the readability, accuracy and consistency of three LLMs in responding to frequently asked questions about bruxism.MethodsThis cross‐sectional observational study utilised the Google Trends tool to identify the 10 most frequent topics about bruxism. Thirty frequently asked questions were selected, which were submitted to ChatGPT‐3.5, ChatGPT‐4 and Gemini at two different times (T1 and T2). The readability was measured using the Flesch Reading Ease (FRE) and Flesch–Kincaid Grade Level (FKG) metrics. The responses were evaluated for accuracy using a three‐point scale, and consistency was verified by comparing responses between T1 and T2. Statistical analysis included ANOVA, chi‐squared tests and Cohen's kappa coefficient considering a p value of 0.5.ResultsIn terms of readability, there was no difference in FRE. The Gemini model showed lower FKG scores than the Generative Pretrained Transformer (GPT)‐3.5 and GPT‐4 models. The average accuracy of the responses was 68.33% for GPT‐3.5, 65% for GPT‐4 and 55% for Gemini, with no significant differences between the models (p = 0.290). Consistency was substantial for all models, with the highest being in GPT‐3.5 (95%). The three LLMs demonstrated substantial agreement between T1 and T2.ConclusionGemini's responses were potentially more accessible to a broader patient population. LLMs demonstrated substantial consistency and moderate accuracy, indicating that these tools should not replace professional dental guidance.
Dynamics of soil properties and pathogen levels in Pacific white shrimp ponds during a production cycle: Implications for aquaculture management
Authors: Chainark Suwanit , Sumetlux Vanida , Chainark Pitchaya 
Published: February 2025

AbstractThis study examines the temporal and spatial variations in soil properties and microbial populations in Pacific white shrimp ponds throughout a production cycle in Phuket Province, southern Thailand, aiming to refine shrimp farming methodologies and enhance pond soil management. We collected soil samples from four ponds across two aquaculture sites at six different stages of the production cycle—Before Sediment Flushing (BSF), After Sediment Flushing (ASF), and during each month of the four‐month cycle (M1 to M4). These samples were analyzed from both central and peripheral pond zones at three soil depths (0–5 cm, 5–10 cm, and 10–15 cm). The results indicated negligible variation in soil characteristics and microbial loads across all stages. Nevertheless, a significant finding was the fluctuation in levels of easily decomposable organic matter (EDOM), which is critical for maintaining soil and water quality and affects both shrimp growth and disease incidence. EDOM levels decreased to their lowest after ASF, then progressively increased, reaching a peak at M4 (p < 0.05). The study suggests that effective sediment flushing post‐cultivation not only mitigates the accumulation of deleterious residues, but also reduces the necessity for prolonged pond desiccation, thereby offering a sustainable strategy to maintain the ecological balance of shrimp ponds over successive farming cycles.
Descriptive representation on K street: Race and gender among federal lobbyists
Authors: Egerod Benjamin C. K. , Hassell Hans J. G. , McCrain Josh , Miller David R. 
Published: February 2025

AbstractWe provide evidence that there are substantial racial and gender gaps among lobbyists. These gender and racial differences are also greater among conservative leaning groups. However, we show, these gaps are decreasing over time. Does demand for minority and female lobbyists play a role in these trends? Although previous work has highlighted the relative scarcity of women and minorities in positions leading to the lobbyist profession (supply), we know less about whether interest groups are interested in hiring qualified women and minorities for such positions (demand). Using a conjoint experiment embedded in a survey of individuals involved in hiring lobbyists, we find greater demand for female and minority lobbyists than for their male and White counterparts, especially among ideological liberals. Our work shows that the lobbying industry does not appear to discount the candidacies of potential female and minority lobbyists.
Polar Coordinates for the 3/2 Stochastic Volatility Model
Authors: Nekoranik Paul 
Published: February 2025

ABSTRACTThe 3/2 stochastic volatility model is a continuous positive process s with a correlated infinitesimal variance process . The exact definition is provided in the Introduction immediately below. By inspecting the geometry associated with this model, we discover an explicit smooth map from to the punctured plane for which the process satisfies an SDE of a simpler form, with independent Brownian motions and the identity matrix as diffusion coefficient. Moreover, is recoverable from the path by a map that depends only on the distance of from the origin and the winding angle around the origin of . We call the process together with its map to the polar coordinate system for the 3/2 model. We demonstrate the utility of the polar coordinate system by using it to write this model's asymptotic smile for all strikes at t = 0. We also state a general theorem on obstructions to the existence of a map that trivializes the infinitesimal covariance matrix of a stochastic volatility model.
Systemic Robustness: A Mean‐Field Particle System Approach
Authors: Bayraktar Erhan , Guo Gaoyue , Tang Wenpin , Zhang Yuming Paul 
Published: February 2025

ABSTRACTThis paper is concerned with the problem of capital provision in a large particle system modeled by stochastic differential equations involving hitting times, which arises from considerations of systemic risk in a financial network. Motivated by Tang and Tsai, we focus on the number or proportion of surviving entities that never default to measure the systemic robustness. First we show that the mean‐field particle system and its limit McKean–Vlasov equation are both well‐posed by virtue of the notion of minimal solutions. We then establish a connection between the proportion of surviving entities in the large particle system and the probability of default in the McKean–Vlasov equation as the size of the interacting particle system tends to infinity. Finally, we study the asymptotic efficiency of capital provision for different drift , which is linked to the economy regime: The expected number of surviving entities has a uniform upper bound if ; it is of order if ; and it is of order if , where the effect of capital provision is negligible.
Remote Regulation by VirB, the Transcriptional Anti‐Silencer of Shigella Virulence Genes, Provides Mechanistic Information
Authors: Cris Cody , Karney Monika M. A. , Rosen Juniper S. , Karabachev Alexander D. , Huezo Elizabeth N. , Wing Helen J. 
Published: February 2025

ABSTRACTClassical models of bacterial transcription show regulators binding close to promoter elements to exert their effect. However, the scope for long‐range regulation exists, especially by nucleoid structuring proteins, like H‐NS. Here, long‐range regulation by VirB, a transcriptional regulator that alleviates H‐NS‐mediated silencing of key virulence genes in Shigella species, is explored in vivo to test the limits of long‐range regulation and provide further mechanistic insight. VirB‐dependent regulation of the well‐characterized icsP promoter persists if its cognate site is repositioned 1 kb, 3.3 kb, and even 4.7 kb further upstream than its native position in a plasmid reporter. VirB‐dependent regulation diminishes with binding site distance. While increasing cellular VirB pools elevated promoter activity in all constructs with wild‐type VirB binding sites, it did not generate a disproportionate increase in promoter activity from remote sites relative to the native site. Since VirB occludes a constitutively active promoter (PT5) when docked adjacent to its −35 element, we next moved the VirB binding site far outside the promoter region. We discovered that VirB still interfered with promoter activity. These findings and those generated from molecular roadblocks engineered around a distally located VirB‐binding site are reconciled with the various models of transcriptional regulation by VirB.
Fundamentals of System Design for Cardiac Pulsed Field Ablation: Optimization of Safety, Efficacy, and Usability
Authors: Koop Brendan 
Published: February 2025

ABSTRACTThe goal of a cardiac pulsed field ablation (PFA) system is to provide safe, effective, and usable therapy for the treatment of cardiac arrhythmias. Achieving this goal is a complex exercise in system design, requiring optimization of catheter, waveform, and dosing. This optimization is often iterative, as myriad design factors are balanced to achieve the goal while making use of computational modeling, bench testing, preclinical animal studies, and human clinical studies to evaluate system performance. It is important for both engineers and clinicians to understand the fundamentals of cardiac PFA system design in order to partner to continuously improve performance of this expanding ablation modality.