bluuebunny/crossref_metadata_2025_split huggingface dataset:
State intervention to bridge the gap: The modernisation of rural Southern Italy (1950–1962)
Authors: Cringoli Gerardo 
Published: February 2025

Abstract
This paper explores the modernisation of rural Southern Italy between 1950 and 1962, focusing on the role of the Cassa per il Mezzogiorno, a public entity created to address the socio-economic divide between the North and South of Italy. The Cassa was central to the restructuring of rural areas, promoting land reclamation, infrastructure development, and the electrification of agricultural regions. The study examines how the ‘agrarian question’ intersected with the broader ‘Southern question’, reflecting persistent economic disparities within Italy. By analysing the early stages (1950–1962) of extraordinary intervention, this article demonstrates that modernisation efforts were aimed not only at reducing regional imbalances but also at addressing structural deficiencies that hindered agricultural productivity. While significant progress was made in modernising rural Southern Italy, this paper argues that the foundational agricultural reforms, although vital, needed to be complemented by broader industrial policies to ensure long-term socio-economic convergence with the more developed North.
Wealth, work, and industriousness, 1670–1860: evidence from rural Swedish probates
Authors: Falk Marcus , Bengtsson Erik , Olsson Mats 
Published: February 2025

Abstract
This article uses a new database of 1,891 probate inventories from rural southern Sweden to investigate the development of rural households’ productive capacity from the late 1600s to the 1860s. Both labourers and farmers improved their material living standards – as measured by the contents of probate inventories – but the labouring households’ ownership of means of production decreased over time. This indicates increasing market involvement and dependency on wage labour. For labourers’ and farmers’ households alike, textile production at home became more important; in the 1860s, half of the labouring households owned spinning wheels and weaving looms, and for farmer households, the shares were even higher. Our study reveals not only the dynamism of the rural pre-industrial Swedish economy but also the unequal nature of this dynamism.
Seeing and Having Seen: On Suffering and Intersubjectivity
Authors: Moore Bryanna 
Published: February 2025

Abstract
Within bioethics, two issues dominate the discourse on suffering: its nature (who can suffer and how) and whether suffering is ever grounds for providing, withholding, or discontinuing interventions. The discussion has focused on the subjective experience of suffering in acute settings or persistent suffering that is the result of terminal, chronic illness. The bioethics literature on suffering, then, is silent about a crucial piece of the moral picture: agents’ intersubjectivity. This paper argues that an account of the intersubjective effects of suffering on caregivers could enrich theories of suffering in two ways: first, by clarifying the scope of suffering beyond the individual at the epicenter, i.e., by providing a fuller account of the effects of suffering (good or bad). Second, by drawing attention to how and why, in clinical contexts, the intersubjective dimensions of suffering are sometimes as important, if not more important, than whether an individual is suffering or not.
The Forum Marsyas on 1st-c. CE lamps
Authors: Le Blanc Robyn 
Published: February 2025

Abstract
A 1st-c. CE lamp from Cyprus, now in the Metropolitan Museum of Art, features a discus design of a satyr on a base before an enclosure. Formerly identified as a nude silenus, the design on this lamp and others with the same decoration in fact illustrates a motif after the Forum Marsyas statue from the Forum Romanum. The statue is typically understood as a symbol of civic libertas, and copies were erected in provincial fora and depicted on civic coinage in the 2nd and 3rd c. CE. This note argues that the lamps enhance our understanding of the Forum Marsyas in two respects. First, the lamps demonstrate that the motif was in provincial circulation ahead of the sculptural and numismatic trend. Second, it is now clear that the Forum Marsyas was used in private contexts, and potentially with a non-civic meaning, more extensively than previously understood. The lamps are therefore significant for understanding the provincial spread and legibility of this important but still enigmatic motif.
Introduction to the special issue: changing dynamics in Southeast Asia-China relations
Authors: Li Mingjiang 
Published: February 2025

AbstractThe evolving global order and regional dynamics have profoundly impacted China-Southeast Asia relations. As the world grapples with the geopolitical implications of intensified US-China competition, the Association of Southeast Asian Nations countries find themselves navigating a complex interplay of opportunities and challenges. The US-led Indo-Pacific strategy has significantly reshaped the geopolitical landscape, yet Southeast Asia’s relations with China are marked by interwoven challenges and opportunities. This special issue includes six papers that cover Malaysia, Vietnam, Thailand, Indonesia, Cambodia, and the Philippines, illustrating how small and medium-sized states navigate an increasingly multipolar world. A central theme across the papers in this special issue is the critical role of domestic factors in shaping each country’s relationship with China.
Party Over Principles: Determinants of Public Opinion on Redistricting Reform
Authors: McLaughlin Peter T. 
Published: February 2025

Abstract
How does the mass public form attitudes on electoral rules and reforms? Existing research on this question reveals a trade-off between principles, such as fairness, and partisan self-interest. I use two survey experiments on state legislative redistricting to explore how voters weigh principles against partisan self-interest when forming opinions on electoral reforms. First, I ask whether the public’s partisan self-interest motivation stems more from individual representation considerations or broader partisan power considerations. I find that both considerations provide a powerful enough incentive to activate partisan self-interest regarding preferences for state legislative district maps. Unexpectedly, the two considerations have quite similar effects on public support for redistricting reforms. Second, I explore the principles versus partisan self-interest trade-off through the lens of loss aversion, a concept developed in behavioral economics. In line with expectations, I find that preventing loss provides a more powerful incentive for Americans to violate democratic principles than achieving partisan gain. In sum, this research sheds light on voters’ decision between principles and partisan self-interest in the formation of opinion on electoral reform.
The dual role of PGAM5 in inflammation
Authors: Qi Yuxin , Rajbanshi Bhavana , Hao Ruihan , Dang Yifan , Xu Churong , Lu Wei , Dai Liming , Zhang Bingjun , Zhang Xiaoling 
Published: February 2025

Abstract
In recent years, the focus on human inflammation in research has increased, with aging-related inflammation widely recognized as a defining characteristic of aging. Inflammation is strongly correlated with mitochondrial dysfunction. Phosphoglycerate mutase family member 5 (PGAM5) is a novel modulator of mitochondrial homeostasis in response to mechanical stimulation. Here we review the structure and sublocalization of PGAM5, introduce its importance in programmed cell death and summarize its crucial roles in the development and progression of inflammatory diseases such as pneumonia, hepatitis, neuroinflammation and aging. Notably, PGAM5 has dual effects on controlling inflammation: distinct PGAM5-mediated mitochondrial functions exhibit cellular heterogeneity, leading to its dual functions in inflammation control. We therefore highlight the double-edged sword nature of PGAM5 as a potential critical regulator and innovative therapeutic target in inflammation. Finally, the challenges and future directions of the use of PGAM5, which has dual properties, as a target molecule in the clinic are discussed. This review provides crucial insights to guide the development of intelligent therapeutic strategies targeting PGAM5-specific regulation to treat intractable inflammatory conditions, as well as the potential extension of its broader application to other diseases to achieve more precise and effective treatment outcomes.
Fasting appetite-related gut hormone responses after weight loss induced by calorie restriction, exercise, or both in people with overweight or obesity: a meta‐analysis
Authors: Jin Zhuoxiu , Li Jiajin , Thackray Alice E. , Shen Tonghui , Deighton Kevin , King James A. , Stensel David J. 
Published: February 2025

Abstract

Objectives
Altered appetite-related gut hormone concentrations may reflect a physiological adaptation facilitating weight regain after weight loss. This review investigates hormonal changes after weight loss achieved through calorie restriction (CR), exercise (EX), or both combined (CREX).

Methods
A systematic search of PubMed (MEDLINE), EMBASE, SPORTDiscus, Cochrane Library, Web of Science, and ClinicalTrials.gov was conducted to identify randomised controlled trials (RCTs) and non-RCTs reporting in a fasting state either pre- and post-intervention appetite-related hormone concentrations or the changes therein after weight loss. The hormones examined were ghrelin, peptide tyrosine tyrosine (PYY), glucagon-like peptide -1 (GLP-1), and cholecystokinin (CCK), in their total and/or active form. Standardised mean differences (SMD) were extracted as the effect size.

Results
127 studies were identified: 19 RCTs, 108 non-RCTs, 1305 and 4725 participants, respectively. In response to weight loss induced by CR, EX or CREX, the meta-analysis revealed an increase in total ghrelin from both RCTs (SMD: 0.55, 95% CI: 0.07–1.04) and non-RCTs (SMD: 0.24, 95% CI: 0.14–0.35). A decrease in acylated ghrelin was identified for RCTs (SMD: –0.58, 95% CI: –1.09 to –0.06) but an increase was observed for non-RCTs (SMD: 0.15, 95% CI: 0.03 to 0.27). Findings also revealed a decrease in PYY (total PYY: SMD: –0.17, 95%CI: –0.28 to –0.06; PYY3-36: SMD: –0.17, 95%CI: –0.32 to –0.02) and active GLP-1 (SMD: -0.16, 95% CI: –0.28 to –0.05) from non-RCTs. Changes in hormones did not differ among the three interventions when controlling for weight loss. Meta-regression indicated that greater weight loss was associated with a greater increase in total ghrelin.

Conclusions
Weight loss induced by CR, EX, or CREX elicits an increase in total ghrelin, but varied responses in other appetite-related hormones. The extent of weight loss influences changes in appetite-related gut hormone concentrations.
Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC
Authors: Lin Xianwen , Liu Zhiwei , Zhou Kun , Li Yuedan , Huang Genjie , Zhang Hao , Shu Tingting , Huang Zhenhua , Wang Yuanyuan , Zeng Wei , Liao Yulin , Bin Jianping , Shi Min , Liao Wangjun , Zhou Wenlan , Huang Na 
Published: February 2025

Abstract

Background
We aimed to develop a machine learning model based on intratumoral and peritumoral 18F-FDG PET/CT radiomics to non-invasively and dynamically predict the response to immunotherapy in non-small cell lung cancer (NSCLC).

Methods
This retrospective study included 296 NSCLC patients, including a training cohort (N = 183), a testing cohort (N = 78), and a TCIA radiogenomic cohort (N = 35). The extreme gradient boosting algorithm was employed to develop the radiomic models.

Results
The COMB-Radscore, which was developed by combining radiomic features from PET, CT, and PET/CT images, had the most satisfactory predictive performance with AUC (ROC) 0.894 and 0.819 in the training and testing cohorts, respectively. Survival analysis has demonstrated that COMB-Radscore is an independent prognostic factor for progression-free survival and overall survival. Moreover, COMB-Radscore demonstrates excellent dynamic predictive performance, with an AUC (ROC) of 0.857, enabling the earlier detection of potential disease progression in patients compared to radiological evaluation solely relying on tumor size. Further radiogenomic analysis showed that the COMB-Radscore was associated with infiltration abundance and functional status of CD8 + T cells.

Conclusions
The radiomic model holds promise as a precise, personalized, and dynamic decision support tool for the treatment of NSCLC patients.
Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage
Authors: Liu Min , Li Yuanyuan , Deng Zhilin , Zhang Ke , Huang Shuying , Xia Jiamin , Feng Yi , Liang Yundan , Sun Chengfu , Liu Xindong , Li Shurong , Su Bingyin , dong Yong , Huang Sizhou 
Published: February 2025

Abstract
Mutation in genes involved in DNA replication continuously disrupt DNA replication and give rise to genomic instability, a critical driver of oncogenesis. To prevent leukemia, immature T lymphocytes with genomic instability often undergo rapid cell death during development. However, the mechanism by which immature T lymphocytes undergo rapid cell death upon genomic instability has been enigmatic. Here we show that zebrafish mcm5 mutation leads to DNA damage in immature T lymphocytes and the immature T cells sensitively undergo rapid cell death. Detailed analyses demonstrated that the immature T lymphocytes undergo rapid apoptosis via upregulation of tp53 and downregulation of bcl2 transcription in mcm5 mutants. Mechanistically, Mcm5 directly binds to Stat1a and facilitates its phosphorylation to enhance bcl2a expression under the conditions of DNA replication stress. However, in mcm5 mutants, the absence of the Mcm5-Stat1 complex decreases Stat1 phosphorylation and subsequent bcl2a transcription, accelerating apoptosis of immature T lymphocytes with genomic instability. Furthermore, our study shows that the role of Mcm5 in T-cell development is conserved in mice. In conclusion, our work identifies a role of Mcm5 in regulating T cell development via Stat1-Bcl2 cascade besides its role in DNA replication, providing a kind of mechanism by which immature T cells with gene mutation-induced DNA damage are rapidly cleared during T lymphocyte development.
Twelve months at 1.5 °C signals earlier than expected breach of Paris Agreement threshold
Authors: Cannon Alex J. 
Published: February 2025

Abstract
June 2024 was the twelfth month in a row with global mean surface temperatures at least 1.5 °C above pre-industrial conditions, but it is not clear if this implies a failure to meet the Paris Agreement goal of limiting long-term warming below this threshold. Here we show that in climate model simulations, the long-term Paris Agreement target is usually crossed well before such a string of unusually warm temperatures occurs.
Antiviral defence arsenal across members of the Bacillus cereus group
Authors: July Elise , Gillis Annika 
Published: February 2025

Abstract
Bacteria co-evolve with bacteriophages to overcome each other’s defence arsenal. Bacillus cereus group gathers bacteria of medical and agricultural importance, including foodborne pathogens. So far, few studies have portrayed a complete defence arsenal of microorganisms, and the role of antiviral systems in the Bacillus cereus group has been overlooked. Here, we investigate the repertoire of defence systems in 6354 B. cereus group’s genomic assemblies, using bioinformatics tools DefenseFinder and PADLOC. Our analyses provide an overview of the diversity and abundance of defence systems in this group, with 83,738 systems distributed by 2 to 33 within each assembly. Comparing PADLOC and DefenseFinder predictions showed that the most prevalent strategy is Restriction-Modification, but many abortive infection systems also intervene in the group’s defence, such as Septu, Gabija and Lamassu. Most defences were encoded on both plasmids and the chromosome, though some tend to have a preferential genomic location. We also studied the defence systems associations within the genomic assemblies. Overall, our results establish a baseline picturing the rich and complex antiviral arsenal encoded by B. cereus group’s species and provide clues for studying co-existing strategies displayed by these bacteria to subvert phages and other MGEs invasions.
Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish
Authors: Carrara Mathieu , Gaillard Anne-Laure , Brion Alice , Duvernois-Berthet Evelyne , Giovannangeli Carine , Concordet Jean-Paul , Pézeron Guillaume 
Published: February 2025

Abstract
Double strand breaks (DSBs) are the most deleterious DNA lesions as they frequently result in mutations when repaired by canonical non homologous end-joining (cNHEJ) and microhomology-mediated end-joining (MMEJ). Here, we investigated the relative importance of cNHEJ and MMEJ pathways during zebrafish embryonic development. We have analyzed the expression of cNHEJ and MMEJ related genes and found that it was dynamic during development and often become increased in specific tissues. We showed that inactivation of nuclear DNA ligase 3 (nLig3) or DNA polymerase theta (Polθ), two key MMEJ factors, did not affect zebrafish development but sensitized embryos to ionizing radiations and that deficiency of Polθ, but not nLig3, profoundly alters the mutation spectrum induced during repair of Cas9-mediated DSBs. By contrast, inactivation of DNA ligase 4, required for cNHEJ, did not seem to sensitize embryos to ionizing radiations nor to affect repair of Cas9-mediated DSBs but resulted in important larval growth defects. Our study underscores the dynamic and context-dependent roles of cNHEJ and MMEJ pathways during zebrafish development, highlighting their differential requirements across developmental stages and in response to genotoxic stress.
Model sensitivity limits attribution of greenhouse gas emissions to polar bear demographic rates
Authors: Wilson Ryan R. , Andersen Erik M. 
Published: February 2025

Abstract
Greenhouse gas emissions continue to increase and negatively affect sea ice conditions that polar bears rely on. It is therefore important to better understand how specific emissions levels affect polar bear demography. A recent study proposed a framework to address this issue, but sensitivity to decisions rules of the approach may limit its utility. We tested how sensitive the approach is to decisions rules related to sea ice concentration, choice of subpopulation boundaries, and modeling choices for bears in the Chukchi Sea and Southern Beaufort Sea subpopulations. We found that the number of ice-free days, number of fasting days, and when 10% of reproductive females exhibited recruitment failure varied considerably depending on equally-valid decisions rules versus those used in the existing study. Whereas the previous study suggested that both subpopulations surpassed the critical number of ice-free days that negatively affect recruitment, we found this threshold was never reached by the Southern Beaufort Sea subpopulation and only once for the Chukchi Sea subpopulation for the decision rules we considered. Our results suggest that the previously published approach is too sensitive to modeling assumptions and choice of decision rules to accurately evaluate the impacts of GHG emissions on polar bear demographic rates.
Machine learning prediction of breast cancer local recurrence localization, and distant metastasis after local recurrences
Authors: Kovács Kristóf Attila , Kerepesi Csaba , Rapcsák Dalma , Madaras Lilla , Nagy Ákos , Takács Anikó , Dank Magdolna , Szentmártoni Gyöngyvér , Szász Attila Marcell , Kulka Janina , Tőkés Anna Mária 
Published: February 2025

Abstract
Local recurrences (LR) can occur within residual breast tissue, chest wall, skin, or newly formed scar tissue. Artificial intelligence (AI) technologies can extract a wide range of tumor features from large datasets helping in oncological decision-making. Recently, machine learning (ML) models have been developed to predict breast cancer recurrence or distant metastasis (DM). However, there is still a lack of models that consider the localization of LR as a tumor feature. To address this gap, here, we analysed data from 154 patients including pathological, clinical, and follow-up data (with an average follow-up of 133.16 months) on both primary tumors (PT) and recurrences. By using ML methods we predicted the localization of LR and the occurrence of DM after LR. The performance (ROC AUC) of the best ML models was 0.75, and 0.69 for predicting LR in breast parenchyma, and surgical scar tissue, respectively, and 0.74 for predicting DM after LR. We identified recurrence localization, and the time elapsed between the detection of primary breast carcinoma and the recurrence, and adjuvant chemotherapy as the most important features associated with further DM. We conclude that combining traditional prognostic factors with ML may provide important tools in the risk assessment of patients with breast LR.
Intrapartum Glycemic Control with Insulin Infusion versus Rotating Fluids: A Randomized Controlled Trial
Authors: Sullivan Maranda , Angras Kajal , Boyd Victoria , Young Amanda J. , Mackeen A. Dhanya , Paglia Michael J. 
Published: February 2025

Objective This study aimed to evaluate rotating intravenous (IV) fluids compared with insulin infusion for maternal intrapartum glycemic control of neonatal blood glucose within 2 hours of birth.
Study Design This randomized controlled trial compared the use of rotating IV fluids to continuous insulin infusion for intrapartum glycemic control for patients with type II diabetes mellitus (DM) or medication-controlled gestational diabetes (A2GDM). A sample size of 74 participants was studied to detect a 10-mg/dL difference in neonatal blood glucose within 2 hours of birth between the groups with a standard deviation of 15, 80% power, and α 0.05. Secondary neonatal outcomes included neonatal blood glucose within 24 hours after birth, Apgar < 7 at 5 minutes, and a composite including neonatal hypoglycemia, NICU admission, hyperbilirubinemia, and respiratory distress syndrome. Secondary maternal outcomes included intrapartum hypoglycemia, blood glucose immediately prior to delivery, mode of delivery, and postpartum complications. Both intention-to-treat (ITT) and per-protocol (PP) analyses were performed.
Results A total of 114 patients were randomized, 57 in each arm. For the PP analysis, 51 patients were analyzed in the rotating IV fluids arm and 32 patients in the insulin infusion arm. There was no significant difference in neonatal blood glucose within 2 hours of birth when rotating IV fluids were used (ITT: 54.5 mg/dL [IQR: 42.5, 72.5], PP: 56.0 mg/dL [IQR: 42.0, 76.0]) when compared with an insulin infusion (ITT: 59.0 mg/dL [IQR: 41.0, 69.0], PP: 62.5 mg/dL [IQR: 44.5, 68.5], p = 0.89 [ITT] and p = 0.68 [PP]). No significant differences were noted in secondary outcomes. The median intrapartum maternal blood glucose was 98.5 mg/dL (IQR: 90.5, 105.0) in the rotating fluids arm and 96.3 mg/dL (IQR: 90.0, 108.5) in the insulin infusion arm (p = 0.96), and the rate of neonatal hypoglycemia was 11.8 versus 15.6%, respectively (p = 0.61) in the PP analysis.
Conclusion There was no difference in neonatal blood glucose within 2 hours of birth when rotating IV fluids were used for intrapartum glycemic control compared with a continuous insulin infusion.
Key Points