bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibroblast selection in scleroderma
Authors: Botstein Gary R. , Sherer Glenn K. , Carwile Leroy E. 
Published: February 2007

AbstractHuman preputial skin fibroblasts were cloned in vitro, and studies in 21 clones were shown to exhibit a 3‐fold difference in collagen synthesis; this heterogeneity of phenotypic expression was conserved over multiple population doublings. When the clones were exposed to sera from 10 scleroderma patients, selective growth of high‐collagen‐producing fibroblasts was observed. Prostaglandin E2 abrogated the selective effect of scleroderma serum on high‐collagen‐producing fibroblast clones. Besides enhanced collagen synthesis, these clones of normal fibroblasts shared an insensitivity to feeding schedule with fibroblasts from scleroderma skin. These data raise the possibility that scleroderma represents a process of selection of fibroblasts programmed to produce increased amounts of collagen.
Fibrositis and psychologic disturbance
Authors: Payne Timothy C. , Leavitt Frank , Garron David C. , Katz Robert S. , Golden Harvey E. , Glickman Paul B. , Vanderplate Cal 
Published: February 2007

AbstractThirty patients with fibrositis and 2 control groups, one of rheumatoid arthritis patients and the other of arthritis patients with other than rheumatoid arthritis, were compared on the basis of the Minnesota Multiphasic Personality Inventory (MMPI) to assess the role of psychologic factors in fibrositis. Patients with fibrositis differed in both elevation and variability in their MMPI profiles, indicating that they were more psychologically disturbed than patients with rheumatoid or other types of arthritis. The fact that almost all of the fibrositis patients' MMPI scales were higher suggests that we might be dealing with a number of different psychologic disturbances that have stiffness and musculoskeletal pain as principal and common symptoms.
Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27
Authors: Leirisalo Marjatta , Skylv Grethe , Kousa Merja , Voipio‐Pulkki Liisa‐Maria , Suoranta Hannu , Nissilä Martti , Hvidman Lone , Nielsen Erik Damm , Svejgaard Arne , Tiilikainen Anja , Laitinen Ossi 
Published: February 2007

AbstractAn analysis of 160 patients with Reiter's disease, 144 with yersinia arthritis, and 9 with salmonella arthritis was performed. Complete or incomplete Reiter's syndrome was observed in one‐third of the patients with yersinia arthritis and in most of those with salmonella arthritis. During the followup period, chronic back pain and joint symptoms were frequent in all the patient groups. Patients who were HLA—B27 positive had a more severe acute disease (more frequent back pain, urologic symptoms, mucocutaneous manifestations, and a longer duration of the disease) and more frequent chronic back pain and sacroiliitis.
Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis
Authors: Hooks John J. , Jordan George W. , Cupps Thomas , Moutsopoulos Haralampos M. , Fauci Anthony S. , Notkins Abner Louis 
Published: February 2007

AbstractRecently, we found interferon in the sera of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma, and Sjögren's syndrome. In this study, we surveyed a variety of other immunologically mediated diseases. We did not find interferon in the sera of patients with Wegener's granulomatosis, sarcoidosis, infectious mononucleosis, minimal change nephritis, kidney transplants, myasthenia gravis, or uveitis, but we did find this protein in the sera of patients with active systemic and cutaneous vasculitis. Attempts to characterize the interferon in the sera of patients with systemic lupus erythematosus and vasculitis revealed that antibody to alpha (leukocyte) interferon, but not to beta (fibroblast) interferon, partially or completely neutralized the antiviral activity. The failure of antibody to alpha interferon to completely neutralize the antiviral activity in certain specimens and the lability of the antiviral activity in some specimens to pH 2.0 treatment both suggest that more than one type of interferon was present.
High rate of death caused by systemic lupus erythematosus among U. S. residents of asian descent
Authors: Kaslow Richard A. 
Published: February 2007

AbstractFrom 1968 through 1976, adjusted annual rates of death from systemic lupus erythematosus, based on National Center for Health Statistics data from the 12 states with most (88%) of the Asian population, were higher for Chinese, Japanese, and Filipinos than for whites in the United States. These Asian subgroups had a combined average annual mortality rate significantly higher than that of whites whether Hawaii was included (6.8/million for Asians versus 2.8 for whites) or excluded (6.0 versus 2.8).
In vitro cartilage degradation by escherichia coli and staphylococcus aureus
Authors: Smith R. Lane , Merchant Thomas C. , Schurman David J. 
Published: February 2007

AbstractEffects of Escherichia coli and Staphylococcus aureus on cartilage and chondrocytes in culture are reported. Under these conditions, bacterial effects on cartilage degradation and cell viability are measured in the absence of inflammation. E coli causes a 28% loss and S aureus an 83% loss of cartilage glycosaminoglycan within 48 hours. Collagen content is unchanged. Both bacterial species induce chondrocyte death in explants and in monolayers within 48 hours. Bacterial effects on glycosaminoglycans and cell viability do not result from depletion of nutrients from the culture medium. Serum in the culture media inhibits the bacterial effects on cartilage degradation but does not prevent cell death.
The association of antinuclear antibodies, antilymphocyte antibodies, and c4 activation among the relatives of children with systemic lupus erythematosus. preferential activation of complement in sisters
Authors: Lehman THOMAS J. A. , Curd John G. , Zvaifler Nathan J. , Hanson Virgil 
Published: February 2007

AbstractWe studied 31 children with systemic lupus erythematosus (SLE) and 108 first‐degree relatives of the children to determine if HLA type, familial relationship to patient, or gender influenced the familial aggregation of SLE and the serologic and serum complement abnormalities associated with SLE. There were no significant relationships between the presence of antinuclear antibodies (ANA), antilymphocyte antibodies (ALA), or circulating immune complexes. Furthermore, there was no correlation between the occurrence of ANA, ALA, or circulating immune complexes with HLA type or relationship to patient. Both ANA and ALA were associated with a reduction in the mean serum C4 level, without a corresponding reduction in mean serum C3 or CH50. The reduction in mean serum C4 level with ALA occurred without regard to the subject's relationship to the patient, but the reduction in mean serum C4 level with ANA was significant only among the sisters. Because of these data, it seems that the sisters of patients with SLE are more likely than other relatives to have activation of the complement system in association with serologic abnormalities. Those sisters with ANA and ALA had the greatest amount of complement activation and may be the relatives at greatest risk for the subsequent development of SLE.
Controlled multicenter trial of tiopronin and D‐penicillamine for rheumatoid arthritis
Authors: Pasero Giampiero , Pellegrini Pietro , Ambanelli Umberto , Ciompi Maria Laura , Colamussi Vincenzo , Ferraccioli Gianfranco , Barbieri Paola , Mazzoni Maria Rosa , Menegale Germano , Trippi Donatella 
Published: February 2007

AbstractFifty‐seven patients took part in a controlled double‐blind trial between tiopronin and D‐penicillamine as basic treatment for rheumatoid arthritis. Thirty‐nine (19 receiving tiopronin, 20 receiving D‐penicillamine) completed the trial after 1 year. Both drugs resulted in a decrease of the erythrocyte sedimentation rate, Ritchie index, and Lee index and in a sparing effect on symptomatic antiinflammatory therapy. Improvement in these variables was statistically highly significant at any interval with tiopronin, but was sometimes less or not at all significant with D‐penicillamine. Nevertheless, the difference in effects between the 2 drugs never reached statistical significance. Six patients receiving tiopronin and 6 receiving D‐penicillamine were taken out of the experiment because of side effects.
Mechanisms of abnormal platelet aggregation in systemic lupus erythematosus
Authors: Dorsch Carole A. , Meyerhoff John 
Published: February 2007

AbstractPlatelet aggregation was measured in 14 patients with systemic lupus erythematosus (SLE) and 13 normal controls. Ten SLE patients (group I) showed decreased responsiveness to collagen, while aggregation was normal in 4 (group II). Group I patients also responded poorly to epinephrine. Platelets from SLE patients did not differ from controls in the production of malondialdehyde in response to N‐ethylmaleimide, suggesting intact prostaglandin synthetic pathways. However, a significant decrease (P < 0.005) in platelet levels of the dense granule constituent, serotonin, was noted in group I SLE patients. Treatment of SLE platelet‐rich plasma with deoxyribonuclease (DNase) resulted in enhancement of collagen‐induced aggregation in 4 group I SLE patients, but not in 1 group II or 8 normal individuals. These results suggest that defective aggregation in SLE platelets may be partially related to a storage pool deficiency state. However, the ability to restore aggregation to collagen by digestion of platelet‐rich plasma with DNase indicates that the defect is reversible and that it is perhaps mediated by plasma or platelet‐associated DNA.
Olecranon bursitis related to calcium pyrophosphate dihydrate crystal deposition disease. Clinical and pathologic study
Authors: Gerster Jean‐C. , Lagier René , Boivin Georges 
Published: February 2007

AbstractA case of olecranon bursitis in an 81‐year‐old patient is presented. Analysis of the bursal fluid revealed positive birefringent crystals; radiographs showed calcifications in the distal triceps tendon. A bursectomy was performed. X‐ray diffraction analyses demonstrated calcium pyrophosphate dihydrate patterns in a subcutaneous “tophus”s and in a specimen of the tendon. On histologic examination, there was a bursitis with positive birefringent crystals on the bursa's inner surface; histologic images of “chondrocalcinosis's's were observed in and around the tendon. It is concluded that bursitis may be part of the extraarticular manifestations of calcium pyrophosphate dihydrate crystal deposition disease.
A syndrome of seronegative enthesopathy and arthropathy in children
Authors: Rosenberg Alan M. , Petty Ross E. 
Published: February 2007

AbstractThirty‐nine children with a syndrome of seronegative enthesopathy and arthropathy were evaluated. The group included 25 patients with no apparent underlying primary disease and 13 with either ankylosing spondylitis, inflammatory bowel disease, reactive arthritis, or Reiter's syndrome. Significant distinguishing characteristics of the group included male predominance, late age at onset, positive family histories of arthritis, oligoarthropathy, axial skeleton involvement, and the presence of the B27 histocompatibility antigen. This syndrome is distinguishable from other childhood rheumatic disorders, including juvenile rheumatoid arthritis. Its recognition may reliably identify children with the prodromal manifestations of seronegative spondylarthropathies.
The arthritis impact measurement scales. further investigations of a health status measure
Authors: Meenan Robert F. , Gertman Paul M. , Mason John H. , Dunaif Richard 
Published: February 2007

AbstractThe Arthritis Impact Measurement Scales (AIMS) have been developed to assess the health status of arthritis patients. In this study, the self‐administered AIMS questionnaire, which includes scales designed to measure the physical, psychologic, and social aspects of health status, was completed by 625 patients with various forms of arthritis. A comprehensive battery of analytic techniques was used to investigate the performance of these scales in this large sample. The results confirmed the reliability and validity of the AIMS instrument. They also showed that AIMS performs well in at least 4 major types of arthritis, in a range of sociodemographic groups, and across time. These findings emphasize the strengths of the AIMS approach and suggest that the instrument will prove useful as a tool to assess arthritis outcome in a wide variety of clinical settings.
Circulating immune complexes in eosinophilic fasciitis
Authors: Seibold James R. , Rodnan Gerald P. , Medsger Thomas A. , Winkelstein Alan 
Published: February 2007

AbstractSerum immune complexes were measured in 22 patients with eosinophilic fasciitis, 8 of whom had serial determinations. Elevated levels were found by Raji cell radioimmunoassay in 14 (64%) patients, by agarose gel electrophoresis in 13 (59%), and by C1q agglutination‐inhibition in 9 (41%). Elevated levels by Raji cell assay were present more frequently at times of active disease [17 of 22 sera (77%)] than at times of inactive disease [2 of 24 (8%) (P<0.0005)] and were more closely correlated with disease activity than were eosinophilia, hypergammaglobulinemia, or increased erythrocyte sedimentation rate.
Hypertrophic osteoarthropathy in cyanotic congenital heart disease. its prevalence and relationship to bypass of the lung
Authors: Martínez‐Lavín Manuel , Bobadilla MaríA , Casanova José , Attié Fause , Martínez Marco 
Published: February 2007

AbstractThe frequency of hypertrophic osteoarthropathy in cyanotic congenital heart disease has previously been considered to be very low. Only a few isolated reports have described such an association. We studied 32 consecutive patients older than 6 years with various types of cyanotic congenital heart disease and examined each case for hypertrophic osteoarthropathy. We also assessed the role of the altered cardiopulmonary hemodynamics in the development of hypertrophic osteoarthropathy by means of cardiac catheterization. Our results showed that 31% of the patients had hypertrophic osteoarthropathy. When the hemodynamic parameters of the group of patients with hypertrophic osteoarthropathy were compared with those of the remaining patients, we found significant differences in the systemic blood flow (P ⩽ 0.05), right‐to‐left shunt (P ⩽ 0.05), and arterial oxygen unsaturation (P ⩽ 0.005). Thus, we found a much higher prevalence of hypertrophic osteoarthropathy in patients with cyanotic congenital heart disease than has previously been recognized. The development of hypertrophic osteoarthropathy is related to the degree of bypass of the lung. This is consistent with the concept that hypertrophic osteoarthropathy results from mediators in the systemic venous circulation that escape inactivation in the pulmonary capillary bed.
Immobilization of the knee prevents osteoarthritis after anterior cruciate ligament transection
Authors: Palmoski Marshall J. , Brandt Kenneth D. 
Published: February 2007

AbstractThe effect of immobilization of the knee in flexion on the development of osteoarthritis was studied in dogs that had undergone transection of the anterior cruciate ligament. Knees of dogs that were permitted ad libitum ambulation in a pen for 12 weeks after transection of the ligament showed osteophytes and fibrillation and a decrease in proteoglycan (uronic acid) content, although thickness of the articular cartilage was normal. Proteoglycan synthesis was 80% greater (P < 0.01) than that in cartilage from the contralateral knee, and more than twice the normal proportion of the total proteoglycans was present in the medium of cultures of cartilage from the unstable knee (P < 0.01). Similarly, the proportion of total tissue proteoglycans extracted with 0.4M guanidinium chloride was 3 times greater than normal (P < 0.01). In contrast, osteophytes were not seen when the leg was immobilized in flexion immediately after transection of the ligament, and the articular surface remained intact. The cartilage became atrophic, however, and its proteoglycan content (uronic acid) was diminished; proteoglycan synthesis was decreased to 61% of the level in cartilage from the contralateral knee, although proteoglycan extractability was normal. Knee cartilage from these legs that were immobilized after transection, therefore, resembled that from dogs whose leg had been immobilized without cruciate ligament transection. In cartilage from all operated and/or immobilized joints the proportion of proteoglycans that interacted with hyaluronic acid in vitro was diminished, because of a defect in the hyaluronate‐binding region of the proteoglycan.
Histoplasmosis presenting with joint pain and hilar adenopathy. “pseudosarcoidosis”
Authors: Thornberry Denise K. , Wheat L. Joseph , Brandt Kenneth D. , Rosenthal Jerome 
Published: February 2007

AbstractDuring 2 recent epidemics of histoplasmosis in Indianapolis, 7 patients with hilar adenopathy and joint complaints were identified who were initially considered to have sarcoidosis, but in whom histoplasmosis was ultimately diagnosed on the basis of a positive culture for Histoplasma capsulatum or serologic studies. Articular features were the sole presenting complaints in 3 of these patients. All had arthralgias, which were generalized or confined to the lower extremities and were additive rather than migratory. Only 1 patient had joint swelling. Two had erythema nodosum. In all but 1 patient, the articular symptoms resolved rapidly and completely with minimal therapy. The data emphasize that sarcoidosis is a diagnosis of exclusion and that granulomatous infectious diseases must be excluded in patients with hilar adenopathy and joint disease.
Relationship of clinical findings in systemic lupus erythematosus to seroreactivity
Authors: Rothschild Bruce M. , Jones John Verrier , Chesney Carolyn , David Pifer D. , Thompson Lee D. , James Karen K. , Badger Harriette 
Published: February 2007

AbstractWe have characterized 52 consecutive patients fulfilling 4 or more of the American Rheumatism Association criteria for systemic lupus erythematosus in order to provide, for the first time, a homogeneous sample for statistical comparison of antinuclear antibody (ANA)‐positive and ANA‐negative groups. Ten patients (19%) were seronegative. There was no significant difference in age, disease activity, organ system involvement, erythrocyte sedimentation rate, immune complex levels, or C3 levels. The ANA‐negative group showed a higher incidence of involvement for whites and men. Leukopenia, lower levels of antibody to DNA, and higher C4 levels were also characteristic of the ANA‐negative group.
The glycosaminoglycans in menisci in experimental and natural osteoarthritis
Authors: Adams Mark E. , Billingham Michael E. J. , Muir Helen 
Published: February 2007

AbstractThe glycosaminoglycans in the menisci of beagles 5–7 years old were analyzed at various times after osteoarthritis was induced by sectioning the anterior cruciate ligament of one knee; the unoperated knee served as control. In the first month after induction, there were signs of inflammation in the operated joint. After 1 week, the water content was elevated and the glycosaminoglycan content (per dry weight) was reduced. The content of keratan sulfate decreased more than that of chondroitin sulfate, but the hyaluronic acid content did not change consistently. The relative proportions of chondroitin‐4‐sulfate, chondroitin‐6‐sulfate, and dermatan sulfate remained unchanged. After 3–18 months, the glycosaminoglycan levels reverted to normal, and there was some evidence that after 15–18 months, they were elevated above normal. These results, together with results obtained from single examples of mild and severe osteoarthritis in working foxhounds, suggest that, in contrast to articular cartilage, the meniscus is capable of some regeneration in response to injury.
Pancreatitis with arthropathy and subcutaneous fat necrosis
Authors: Alexander Wilson H. , Askari Ali D. , Neiderhiser Dewey H. , MyronJohnson A. , Andrews Brian S. , Hoskins Lansing C. 
Published: February 2007

AbstractThe occurrence of peripheral fat necrosis in exceptional cases of pancreatic disease is not well understood. We report studies on such a patient with arthropathy and subcutaneous nodules. Examination of serial serum samples demonstrated striking elevations of the pancreatic enzymes phospholipase A, 3–3.4 units/ml (normal 0.17–0.41); lipase, 7–39 Sigma‐Tietz units/ml (normal < 1); immunoreactive trypsin, 912–3,207 ng/ml (normal 12–41). The distinguishing characteristic of the patient's synovial fluid was a marked elevation of hydrolized fatty acids (680 mg/dl versus 19 ± 19 in control inflammatory joint fluids). Synovial fluid fatty acid distribution was identical to values for tissue fat. In contrast, serum fatty acid levels and distribution were normal. No associated proteinase inhibitor or significant immunologic abnormality was detected. Certain properties of adipose cells and lipolytic enzymes may help explain the characteristically selective necrosis of fat cells observed in this syndrome.
Free fatty acids in the pancreatitic arthritis syndrome
Authors: Simkin Peter A. , Brunzell John D. , Wisner David , Fiechtner Justus J. , Carlin Jeffrey S. , Willkens Robert F. 
Published: February 2007

AbstractFat necrosis and arthritis occur in some individuals with pancreatitis. The intraarticular free fatty acid concentration was found to be markedly elevated in 2 patients with this pancreatitic arthritis syndrome. Injection of free fatty acids into rabbit knees reproduced the inflammatory synovial response including intracellular fat globules within leukocytes. Free fatty acids exceeding the available binding sites of albumin appear to mediate the extrapancreatic inflammatory manifestations of this syndrome.
The natural disease course of ankylosing spondylitis
Authors: Carette Simon , Graham Donald , Little Hugh , Rubenstein Joel , Rosen Philip 
Published: February 2007

AbstractOne hundred fifty war veterans with ankylosing spondylitis were entered into a prospective study in 1947. In 1957, 142 were traced, and they have been reviewed periodically. Eighty‐one of these patients were still alive in 1980. Information was obtained from 67 (83%) of the survivors and 51 were reexamined. This report is based on the clinical findings in these 51 patients, who have a mean disease duration of 38 years. Forty‐seven (92%) were functioning well. The disease in 21 (41%) had progressed to cause severe spinal restriction. Of those, 12 had peripheral joint involvement early in their course and 9 had iritis. Seventy‐four percent of the patients who had mild spinal restriction after 10 years did not progress to having more severe restriction. Eighty‐one percent of the patients who had severe spinal restriction in 1980 were severely restricted within the first 10 years. Hips that were normal after 10 years of disease did not become diseased subsequently. This study suggests that a predictable pattern of ankylosing spondylitis emerges within the first 10 years of the disease.